                           SEQUENCE LISTING


<110> CRISPR THERAPEUTICS AG

<120> MATERIALS AND METHODS FOR TREATMENT OF PAIN RELATED DISORDERS

<130> CT76-PCT / 170152PCT

<150> 62/358,763
<151> 2016-07-06

<150> 62/461,874
<151> 2017-02-22

<160> 125503 

<170> PatentIn version 3.5

<210> 1
<211> 1368
<212> PRT
<213> Streptococcus pyogenes

<400> 1
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 2
<211> 4107
<212> DNA
<213> Streptococcus pyogenes

<400> 2
atggataaga aatactcaat aggcttagat atcggcacaa atagcgtcgg atgggcggtg       60

atcactgatg aatataaggt tccgtctaaa aagttcaagg ttctgggaaa tacagaccgc      120

cacagtatca aaaaaaatct tataggggct cttttatttg acagtggaga gacagcggaa      180

gcgactcgtc tcaaacggac agctcgtaga aggtatacac gtcggaagaa tcgtatttgt      240

tatctacagg agattttttc aaatgagatg gcgaaagtag atgatagttt ctttcatcga      300

cttgaagagt cttttttggt ggaagaagac aagaagcatg aacgtcatcc tatttttgga      360

aatatagtag atgaagttgc ttatcatgag aaatatccaa ctatctatca tctgcgaaaa      420

aaattggtag attctactga taaagcggat ttgcgcttaa tctatttggc cttagcgcat      480

atgattaagt ttcgtggtca ttttttgatt gagggagatt taaatcctga taatagtgat      540

gtggacaaac tatttatcca gttggtacaa acctacaatc aattatttga agaaaaccct      600

attaacgcaa gtggagtaga tgctaaagcg attctttctg cacgattgag taaatcaaga      660

cgattagaaa atctcattgc tcagctcccc ggtgagaaga aaaatggctt atttgggaat      720

ctcattgctt tgtcattggg tttgacccct aattttaaat caaattttga tttggcagaa      780

gatgctaaat tacagctttc aaaagatact tacgatgatg atttagataa tttattggcg      840

caaattggag atcaatatgc tgatttgttt ttggcagcta agaatttatc agatgctatt      900

ttactttcag atatcctaag agtaaatact gaaataacta aggctcccct atcagcttca      960

atgattaaac gctacgatga acatcatcaa gacttgactc ttttaaaagc tttagttcga     1020

caacaacttc cagaaaagta taaagaaatc ttttttgatc aatcaaaaaa cggatatgca     1080

ggttatattg atgggggagc tagccaagaa gaattttata aatttatcaa accaatttta     1140

gaaaaaatgg atggtactga ggaattattg gtgaaactaa atcgtgaaga tttgctgcgc     1200

aagcaacgga cctttgacaa cggctctatt ccccatcaaa ttcacttggg tgagctgcat     1260

gctattttga gaagacaaga agacttttat ccatttttaa aagacaatcg tgagaagatt     1320

gaaaaaatct tgacttttcg aattccttat tatgttggtc cattggcgcg tggcaatagt     1380

cgttttgcat ggatgactcg gaagtctgaa gaaacaatta ccccatggaa ttttgaagaa     1440

gttgtcgata aaggtgcttc agctcaatca tttattgaac gcatgacaaa ctttgataaa     1500

aatcttccaa atgaaaaagt actaccaaaa catagtttgc tttatgagta ttttacggtt     1560

tataacgaat tgacaaaggt caaatatgtt actgaaggaa tgcgaaaacc agcatttctt     1620

tcaggtgaac agaagaaagc cattgttgat ttactcttca aaacaaatcg aaaagtaacc     1680

gttaagcaat taaaagaaga ttatttcaaa aaaatagaat gttttgatag tgttgaaatt     1740

tcaggagttg aagatagatt taatgcttca ttaggtacct accatgattt gctaaaaatt     1800

attaaagata aagatttttt ggataatgaa gaaaatgaag atatcttaga ggatattgtt     1860

ttaacattga ccttatttga agatagggag atgattgagg aaagacttaa aacatatgct     1920

cacctctttg atgataaggt gatgaaacag cttaaacgtc gccgttatac tggttgggga     1980

cgtttgtctc gaaaattgat taatggtatt agggataagc aatctggcaa aacaatatta     2040

gattttttga aatcagatgg ttttgccaat cgcaatttta tgcagctgat ccatgatgat     2100

agtttgacat ttaaagaaga cattcaaaaa gcacaagtgt ctggacaagg cgatagttta     2160

catgaacata ttgcaaattt agctggtagc cctgctatta aaaaaggtat tttacagact     2220

gtaaaagttg ttgatgaatt ggtcaaagta atggggcggc ataagccaga aaatatcgtt     2280

attgaaatgg cacgtgaaaa tcagacaact caaaagggcc agaaaaattc gcgagagcgt     2340

atgaaacgaa tcgaagaagg tatcaaagaa ttaggaagtc agattcttaa agagcatcct     2400

gttgaaaata ctcaattgca aaatgaaaag ctctatctct attatctcca aaatggaaga     2460

gacatgtatg tggaccaaga attagatatt aatcgtttaa gtgattatga tgtcgatcac     2520

attgttccac aaagtttcct taaagacgat tcaatagaca ataaggtctt aacgcgttct     2580

gataaaaatc gtggtaaatc ggataacgtt ccaagtgaag aagtagtcaa aaagatgaaa     2640

aactattgga gacaacttct aaacgccaag ttaatcactc aacgtaagtt tgataattta     2700

acgaaagctg aacgtggagg tttgagtgaa cttgataaag ctggttttat caaacgccaa     2760

ttggttgaaa ctcgccaaat cactaagcat gtggcacaaa ttttggatag tcgcatgaat     2820

actaaatacg atgaaaatga taaacttatt cgagaggtta aagtgattac cttaaaatct     2880

aaattagttt ctgacttccg aaaagatttc caattctata aagtacgtga gattaacaat     2940

taccatcatg cccatgatgc gtatctaaat gccgtcgttg gaactgcttt gattaagaaa     3000

tatccaaaac ttgaatcgga gtttgtctat ggtgattata aagtttatga tgttcgtaaa     3060

atgattgcta agtctgagca agaaataggc aaagcaaccg caaaatattt cttttactct     3120

aatatcatga acttcttcaa aacagaaatt acacttgcaa atggagagat tcgcaaacgc     3180

cctctaatcg aaactaatgg ggaaactgga gaaattgtct gggataaagg gcgagatttt     3240

gccacagtgc gcaaagtatt gtccatgccc caagtcaata ttgtcaagaa aacagaagta     3300

cagacaggcg gattctccaa ggagtcaatt ttaccaaaaa gaaattcgga caagcttatt     3360

gctcgtaaaa aagactggga tccaaaaaaa tatggtggtt ttgatagtcc aacggtagct     3420

tattcagtcc tagtggttgc taaggtggaa aaagggaaat cgaagaagtt aaaatccgtt     3480

aaagagttac tagggatcac aattatggaa agaagttcct ttgaaaaaaa tccgattgac     3540

tttttagaag ctaaaggata taaggaagtt aaaaaagact taatcattaa actacctaaa     3600

tatagtcttt ttgagttaga aaacggtcgt aaacggatgc tggctagtgc cggagaatta     3660

caaaaaggaa atgagctggc tctgccaagc aaatatgtga attttttata tttagctagt     3720

cattatgaaa agttgaaggg tagtccagaa gataacgaac aaaaacaatt gtttgtggag     3780

cagcataagc attatttaga tgagattatt gagcaaatca gtgaattttc taagcgtgtt     3840

attttagcag atgccaattt agataaagtt cttagtgcat ataacaaaca tagagacaaa     3900

ccaatacgtg aacaagcaga aaatattatt catttattta cgttgacgaa tcttggagct     3960

cccgctgctt ttaaatattt tgatacaaca attgatcgta aacgatatac gtctacaaaa     4020

gaagttttag atgccactct tatccatcaa tccatcactg gtctttatga aacacgcatt     4080

gatttgagtc agctaggagg tgactga                                         4107


<210> 3
<211> 4107
<212> DNA
<213> Streptococcus pyogenes

<400> 3
atggacaaga agtactccat tgggctcgct atcggcacaa acagcgtcgg ctgggccgtc       60

attacggacg agtacaaggt gccgagcaaa aaattcaaag ttctgggcaa taccgatcgc      120

cacagcataa agaagaacct cattggcgcc ctcctgttcg actccgggga gacggccgaa      180

gccacgcggc tcaaaagaac agcacggcgc agatataccc gcagaaagaa tcggatctgc      240

tacctgcagg agatctttag taatgagatg gctaaggtgg atgactcttt cttccatagg      300

ctggaggagt cctttttggt ggaggaggat aaaaagcacg agcgccaccc aatctttggc      360

aatatcgtgg acgaggtggc gtaccatgaa aagtacccaa ccatatatca tctgaggaag      420

aagcttgtag acagtactga taaggctgac ttgcggttga tctatctcgc gctggcgcat      480

atgatcaaat ttcggggaca cttcctcatc gagggggacc tgaacccaga caacagcgat      540

gtcgacaaac tctttatcca actggttcag acttacaatc agcttttcga agagaacccg      600

atcaacgcat ccggagttga cgccaaagca atcctgagcg ctaggctgtc caaatcccgg      660

cggctcgaaa acctcatcgc acagctccct ggggagaaga agaacggcct gtttggtaat      720

cttatcgccc tgtcactcgg gctgaccccc aactttaaat ctaacttcga cctggccgaa      780

gatgccaagc ttcaactgag caaagacacc tacgatgatg atctcgacaa tctgctggcc      840

cagatcggcg accagtacgc agaccttttt ttggcggcaa agaacctgtc agacgccatt      900

ctgctgagtg atattctgcg agtgaacacg gagatcacca aagctccgct gagcgctagt      960

atgatcaagc gctatgatga gcaccaccaa gacttgactt tgctgaaggc ccttgtcaga     1020

cagcaactgc ctgagaagta caaggaaatt ttcttcgatc agtctaaaaa tggctacgcc     1080

ggatacattg acggcggagc aagccaggag gaattttaca aatttattaa gcccatcttg     1140

gaaaaaatgg acggcaccga ggagctgctg gtaaagctta acagagaaga tctgttgcgc     1200

aaacagcgca ctttcgacaa tggaagcatc ccccaccaga ttcacctggg cgaactgcac     1260

gctatcctca ggcggcaaga ggatttctac ccctttttga aagataacag ggaaaagatt     1320

gagaaaatcc tcacatttcg gataccctac tatgtaggcc ccctcgcccg gggaaattcc     1380

agattcgcgt ggatgactcg caaatcagaa gagaccatca ctccctggaa cttcgaggaa     1440

gtcgtggata agggggcctc tgcccagtcc ttcatcgaaa ggatgactaa ctttgataaa     1500

aatctgccta acgaaaaggt gcttcctaaa cactctctgc tgtacgagta cttcacagtt     1560

tataacgagc tcaccaaggt caaatacgtc acagaaggga tgagaaagcc agcattcctg     1620

tctggagagc agaagaaagc tatcgtggac ctcctcttca agacgaaccg gaaagttacc     1680

gtgaaacagc tcaaagaaga ctatttcaaa aagattgaat gtttcgactc tgttgaaatc     1740

agcggagtgg aggatcgctt caacgcatcc ctgggaacgt atcacgatct cctgaaaatc     1800

attaaagaca aggacttcct ggacaatgag gagaacgagg acattcttga ggacattgtc     1860

ctcaccctta cgttgtttga agatagggag atgattgaag aacgcttgaa aacttacgct     1920

catctcttcg acgacaaagt catgaaacag ctcaagaggc gccgatatac aggatggggg     1980

cggctgtcaa gaaaactgat caatgggatc cgagacaagc agagtggaaa gacaatcctg     2040

gattttctta agtccgatgg atttgccaac cggaacttca tgcagttgat ccatgatgac     2100

tctctcacct ttaaggagga catccagaaa gcacaagttt ctggccaggg ggacagtctt     2160

cacgagcaca tcgctaatct tgcaggtagc ccagctatca aaaagggaat actgcagacc     2220

gttaaggtcg tggatgaact cgtcaaagta atgggaaggc ataagcccga gaatatcgtt     2280

atcgagatgg cccgagagaa ccaaactacc cagaagggac agaagaacag tagggaaagg     2340

atgaagagga ttgaagaggg tataaaagaa ctggggtccc aaatccttaa ggaacaccca     2400

gttgaaaaca cccagcttca gaatgagaag ctctacctgt actacctgca gaacggcagg     2460

gacatgtacg tggatcagga actggacatc aatcggctct ccgactacga cgtggctgct     2520

atcgtgcccc agtcttttct caaagatgat tctattgata ataaagtgtt gacaagatcc     2580

gataaagcta gagggaagag tgataacgtc ccctcagaag aagttgtcaa gaaaatgaaa     2640

aattattggc ggcagctgct gaacgccaaa ctgatcacac aacggaagtt cgataatctg     2700

actaaggctg aacgaggtgg cctgtctgag ttggataaag ccggcttcat caaaaggcag     2760

cttgttgaga cacgccagat caccaagcac gtggcccaaa ttctcgattc acgcatgaac     2820

accaagtacg atgaaaatga caaactgatt cgagaggtga aagttattac tctgaagtct     2880

aagctggtct cagatttcag aaaggacttt cagttttata aggtgagaga gatcaacaat     2940

taccaccatg cgcatgatgc ctacctgaat gcagtggtag gcactgcact tatcaaaaaa     3000

tatcccaagc ttgaatctga atttgtttac ggagactata aagtgtacga tgttaggaaa     3060

atgatcgcaa agtctgagca ggaaataggc aaggccaccg ctaagtactt cttttacagc     3120

aatattatga attttttcaa gaccgagatt acactggcca atggagagat tcggaagcga     3180

ccacttatcg aaacaaacgg agaaacagga gaaatcgtgt gggacaaggg tagggatttc     3240

gcgacagtcc ggaaggtcct gtccatgccg caggtgaaca tcgttaaaaa gaccgaagta     3300

cagaccggag gcttctccaa ggaaagtatc ctcccgaaaa ggaacagcga caagctgatc     3360

gcacgcaaaa aagattggga ccccaagaaa tacggcggat tcgattctcc tacagtcgct     3420

tacagtgtac tggttgtggc caaagtggag aaagggaagt ctaaaaaact caaaagcgtc     3480

aaggaactgc tgggcatcac aatcatggag cgatcaagct tcgaaaaaaa ccccatcgac     3540

tttctcgagg cgaaaggata taaagaggtc aaaaaagacc tcatcattaa gcttcccaag     3600

tactctctct ttgagcttga aaacggccgg aaacgaatgc tcgctagtgc gggcgagctg     3660

cagaaaggta acgagctggc actgccctct aaatacgtta atttcttgta tctggccagc     3720

cactatgaaa agctcaaagg gtctcccgaa gataatgagc agaagcagct gttcgtggaa     3780

caacacaaac actaccttga tgagatcatc gagcaaataa gcgaattctc caaaagagtg     3840

atcctcgccg acgctaacct cgataaggtg ctttctgctt acaataagca cagggataag     3900

cccatcaggg agcaggcaga aaacattatc cacttgttta ctctgaccaa cttgggcgcg     3960

cctgcagcct tcaagtactt cgacaccacc atagacagaa agcggtacac ctctacaaag     4020

gaggtcctgg acgccacact gattcatcag tcaattacgg ggctctatga aacaagaatc     4080

gacctctctc agctcggtgg agactaa                                         4107


<210> 4
<211> 4140
<212> DNA
<213> Streptococcus pyogenes

<400> 4
atggacaaga agtactccat tgggctcgat atcggcacaa acagcgtcgg ctgggccgtc       60

attacggacg agtacaaggt gccgagcaaa aaattcaaag ttctgggcaa taccgatcgc      120

cacagcataa agaagaacct cattggcgcc ctcctgttcg actccgggga gacggccgaa      180

gccacgcggc tcaaaagaac agcacggcgc agatataccc gcagaaagaa tcggatctgc      240

tacctgcagg agatctttag taatgagatg gctaaggtgg atgactcttt cttccatagg      300

ctggaggagt cctttttggt ggaggaggat aaaaagcacg agcgccaccc aatctttggc      360

aatatcgtgg acgaggtggc gtaccatgaa aagtacccaa ccatatatca tctgaggaag      420

aagcttgtag acagtactga taaggctgac ttgcggttga tctatctcgc gctggcgcat      480

atgatcaaat ttcggggaca cttcctcatc gagggggacc tgaacccaga caacagcgat      540

gtcgacaaac tctttatcca actggttcag acttacaatc agcttttcga agagaacccg      600

atcaacgcat ccggagttga cgccaaagca atcctgagcg ctaggctgtc caaatcccgg      660

cggctcgaaa acctcatcgc acagctccct ggggagaaga agaacggcct gtttggtaat      720

cttatcgccc tgtcactcgg gctgaccccc aactttaaat ctaacttcga cctggccgaa      780

gatgccaagc ttcaactgag caaagacacc tacgatgatg atctcgacaa tctgctggcc      840

cagatcggcg accagtacgc agaccttttt ttggcggcaa agaacctgtc agacgccatt      900

ctgctgagtg atattctgcg agtgaacacg gagatcacca aagctccgct gagcgctagt      960

atgatcaagc gctatgatga gcaccaccaa gacttgactt tgctgaaggc ccttgtcaga     1020

cagcaactgc ctgagaagta caaggaaatt ttcttcgatc agtctaaaaa tggctacgcc     1080

ggatacattg acggcggagc aagccaggag gaattttaca aatttattaa gcccatcttg     1140

gaaaaaatgg acggcaccga ggagctgctg gtaaagctta acagagaaga tctgttgcgc     1200

aaacagcgca ctttcgacaa tggaagcatc ccccaccaga ttcacctggg cgaactgcac     1260

gctatcctca ggcggcaaga ggatttctac ccctttttga aagataacag ggaaaagatt     1320

gagaaaatcc tcacatttcg gataccctac tatgtaggcc ccctcgcccg gggaaattcc     1380

agattcgcgt ggatgactcg caaatcagaa gagaccatca ctccctggaa cttcgaggaa     1440

gtcgtggata agggggcctc tgcccagtcc ttcatcgaaa ggatgactaa ctttgataaa     1500

aatctgccta acgaaaaggt gcttcctaaa cactctctgc tgtacgagta cttcacagtt     1560

tataacgagc tcaccaaggt caaatacgtc acagaaggga tgagaaagcc agcattcctg     1620

tctggagagc agaagaaagc tatcgtggac ctcctcttca agacgaaccg gaaagttacc     1680

gtgaaacagc tcaaagaaga ctatttcaaa aagattgaat gtttcgactc tgttgaaatc     1740

agcggagtgg aggatcgctt caacgcatcc ctgggaacgt atcacgatct cctgaaaatc     1800

attaaagaca aggacttcct ggacaatgag gagaacgagg acattcttga ggacattgtc     1860

ctcaccctta cgttgtttga agatagggag atgattgaag aacgcttgaa aacttacgct     1920

catctcttcg acgacaaagt catgaaacag ctcaagaggc gccgatatac aggatggggg     1980

cggctgtcaa gaaaactgat caatgggatc cgagacaagc agagtggaaa gacaatcctg     2040

gattttctta agtccgatgg atttgccaac cggaacttca tgcagttgat ccatgatgac     2100

tctctcacct ttaaggagga catccagaaa gcacaagttt ctggccaggg ggacagtctt     2160

cacgagcaca tcgctaatct tgcaggtagc ccagctatca aaaagggaat actgcagacc     2220

gttaaggtcg tggatgaact cgtcaaagta atgggaaggc ataagcccga gaatatcgtt     2280

atcgagatgg cccgagagaa ccaaactacc cagaagggac agaagaacag tagggaaagg     2340

atgaagagga ttgaagaggg tataaaagaa ctggggtccc aaatccttaa ggaacaccca     2400

gttgaaaaca cccagcttca gaatgagaag ctctacctgt actacctgca gaacggcagg     2460

gacatgtacg tggatcagga actggacatc aatcggctct ccgactacga cgtggatcat     2520

atcgtgcccc agtcttttct caaagatgat tctattgata ataaagtgtt gacaagatcc     2580

gataaaaata gagggaagag tgataacgtc ccctcagaag aagttgtcaa gaaaatgaaa     2640

aattattggc ggcagctgct gaacgccaaa ctgatcacac aacggaagtt cgataatctg     2700

actaaggctg aacgaggtgg cctgtctgag ttggataaag ccggcttcat caaaaggcag     2760

cttgttgaga cacgccagat caccaagcac gtggcccaaa ttctcgattc acgcatgaac     2820

accaagtacg atgaaaatga caaactgatt cgagaggtga aagttattac tctgaagtct     2880

aagctggtct cagatttcag aaaggacttt cagttttata aggtgagaga gatcaacaat     2940

taccaccatg cgcatgatgc ctacctgaat gcagtggtag gcactgcact tatcaaaaaa     3000

tatcccaagc ttgaatctga atttgtttac ggagactata aagtgtacga tgttaggaaa     3060

atgatcgcaa agtctgagca ggaaataggc aaggccaccg ctaagtactt cttttacagc     3120

aatattatga attttttcaa gaccgagatt acactggcca atggagagat tcggaagcga     3180

ccacttatcg aaacaaacgg agaaacagga gaaatcgtgt gggacaaggg tagggatttc     3240

gcgacagtcc ggaaggtcct gtccatgccg caggtgaaca tcgttaaaaa gaccgaagta     3300

cagaccggag gcttctccaa ggaaagtatc ctcccgaaaa ggaacagcga caagctgatc     3360

gcacgcaaaa aagattggga ccccaagaaa tacggcggat tcgattctcc tacagtcgct     3420

tacagtgtac tggttgtggc caaagtggag aaagggaagt ctaaaaaact caaaagcgtc     3480

aaggaactgc tgggcatcac aatcatggag cgatcaagct tcgaaaaaaa ccccatcgac     3540

tttctcgagg cgaaaggata taaagaggtc aaaaaagacc tcatcattaa gcttcccaag     3600

tactctctct ttgagcttga aaacggccgg aaacgaatgc tcgctagtgc gggcgagctg     3660

cagaaaggta acgagctggc actgccctct aaatacgtta atttcttgta tctggccagc     3720

cactatgaaa agctcaaagg gtctcccgaa gataatgagc agaagcagct gttcgtggaa     3780

caacacaaac actaccttga tgagatcatc gagcaaataa gcgaattctc caaaagagtg     3840

atcctcgccg acgctaacct cgataaggtg ctttctgctt acaataagca cagggataag     3900

cccatcaggg agcaggcaga aaacattatc cacttgttta ctctgaccaa cttgggcgcg     3960

cctgcagcct tcaagtactt cgacaccacc atagacagaa agcggtacac ctctacaaag     4020

gaggtcctgg acgccacact gattcatcag tcaattacgg ggctctatga aacaagaatc     4080

gacctctctc agctcggtgg agacagcagg gctgacccca agaagaagag gaaggtgtga     4140


<210> 5
<211> 4200
<212> DNA
<213> Streptococcus pyogenes

<400> 5
atggacaaga agtactccat tgggctcgat atcggcacaa acagcgtcgg ctgggccgtc       60

attacggacg agtacaaggt gccgagcaaa aaattcaaag ttctgggcaa taccgatcgc      120

cacagcataa agaagaacct cattggcgcc ctcctgttcg actccgggga gacggccgaa      180

gccacgcggc tcaaaagaac agcacggcgc agatataccc gcagaaagaa tcggatctgc      240

tacctgcagg agatctttag taatgagatg gctaaggtgg atgactcttt cttccatagg      300

ctggaggagt cctttttggt ggaggaggat aaaaagcacg agcgccaccc aatctttggc      360

aatatcgtgg acgaggtggc gtaccatgaa aagtacccaa ccatatatca tctgaggaag      420

aagcttgtag acagtactga taaggctgac ttgcggttga tctatctcgc gctggcgcat      480

atgatcaaat ttcggggaca cttcctcatc gagggggacc tgaacccaga caacagcgat      540

gtcgacaaac tctttatcca actggttcag acttacaatc agcttttcga agagaacccg      600

atcaacgcat ccggagttga cgccaaagca atcctgagcg ctaggctgtc caaatcccgg      660

cggctcgaaa acctcatcgc acagctccct ggggagaaga agaacggcct gtttggtaat      720

cttatcgccc tgtcactcgg gctgaccccc aactttaaat ctaacttcga cctggccgaa      780

gatgccaagc ttcaactgag caaagacacc tacgatgatg atctcgacaa tctgctggcc      840

cagatcggcg accagtacgc agaccttttt ttggcggcaa agaacctgtc agacgccatt      900

ctgctgagtg atattctgcg agtgaacacg gagatcacca aagctccgct gagcgctagt      960

atgatcaagc gctatgatga gcaccaccaa gacttgactt tgctgaaggc ccttgtcaga     1020

cagcaactgc ctgagaagta caaggaaatt ttcttcgatc agtctaaaaa tggctacgcc     1080

ggatacattg acggcggagc aagccaggag gaattttaca aatttattaa gcccatcttg     1140

gaaaaaatgg acggcaccga ggagctgctg gtaaagctta acagagaaga tctgttgcgc     1200

aaacagcgca ctttcgacaa tggaagcatc ccccaccaga ttcacctggg cgaactgcac     1260

gctatcctca ggcggcaaga ggatttctac ccctttttga aagataacag ggaaaagatt     1320

gagaaaatcc tcacatttcg gataccctac tatgtaggcc ccctcgcccg gggaaattcc     1380

agattcgcgt ggatgactcg caaatcagaa gagaccatca ctccctggaa cttcgaggaa     1440

gtcgtggata agggggcctc tgcccagtcc ttcatcgaaa ggatgactaa ctttgataaa     1500

aatctgccta acgaaaaggt gcttcctaaa cactctctgc tgtacgagta cttcacagtt     1560

tataacgagc tcaccaaggt caaatacgtc acagaaggga tgagaaagcc agcattcctg     1620

tctggagagc agaagaaagc tatcgtggac ctcctcttca agacgaaccg gaaagttacc     1680

gtgaaacagc tcaaagaaga ctatttcaaa aagattgaat gtttcgactc tgttgaaatc     1740

agcggagtgg aggatcgctt caacgcatcc ctgggaacgt atcacgatct cctgaaaatc     1800

attaaagaca aggacttcct ggacaatgag gagaacgagg acattcttga ggacattgtc     1860

ctcaccctta cgttgtttga agatagggag atgattgaag aacgcttgaa aacttacgct     1920

catctcttcg acgacaaagt catgaaacag ctcaagaggc gccgatatac aggatggggg     1980

cggctgtcaa gaaaactgat caatgggatc cgagacaagc agagtggaaa gacaatcctg     2040

gattttctta agtccgatgg atttgccaac cggaacttca tgcagttgat ccatgatgac     2100

tctctcacct ttaaggagga catccagaaa gcacaagttt ctggccaggg ggacagtctt     2160

cacgagcaca tcgctaatct tgcaggtagc ccagctatca aaaagggaat actgcagacc     2220

gttaaggtcg tggatgaact cgtcaaagta atgggaaggc ataagcccga gaatatcgtt     2280

atcgagatgg cccgagagaa ccaaactacc cagaagggac agaagaacag tagggaaagg     2340

atgaagagga ttgaagaggg tataaaagaa ctggggtccc aaatccttaa ggaacaccca     2400

gttgaaaaca cccagcttca gaatgagaag ctctacctgt actacctgca gaacggcagg     2460

gacatgtacg tggatcagga actggacatc aatcggctct ccgactacga cgtggatcat     2520

atcgtgcccc agtcttttct caaagatgat tctattgata ataaagtgtt gacaagatcc     2580

gataaaaata gagggaagag tgataacgtc ccctcagaag aagttgtcaa gaaaatgaaa     2640

aattattggc ggcagctgct gaacgccaaa ctgatcacac aacggaagtt cgataatctg     2700

actaaggctg aacgaggtgg cctgtctgag ttggataaag ccggcttcat caaaaggcag     2760

cttgttgaga cacgccagat caccaagcac gtggcccaaa ttctcgattc acgcatgaac     2820

accaagtacg atgaaaatga caaactgatt cgagaggtga aagttattac tctgaagtct     2880

aagctggtct cagatttcag aaaggacttt cagttttata aggtgagaga gatcaacaat     2940

taccaccatg cgcatgatgc ctacctgaat gcagtggtag gcactgcact tatcaaaaaa     3000

tatcccaagc ttgaatctga atttgtttac ggagactata aagtgtacga tgttaggaaa     3060

atgatcgcaa agtctgagca ggaaataggc aaggccaccg ctaagtactt cttttacagc     3120

aatattatga attttttcaa gaccgagatt acactggcca atggagagat tcggaagcga     3180

ccacttatcg aaacaaacgg agaaacagga gaaatcgtgt gggacaaggg tagggatttc     3240

gcgacagtcc ggaaggtcct gtccatgccg caggtgaaca tcgttaaaaa gaccgaagta     3300

cagaccggag gcttctccaa ggaaagtatc ctcccgaaaa ggaacagcga caagctgatc     3360

gcacgcaaaa aagattggga ccccaagaaa tacggcggat tcgattctcc tacagtcgct     3420

tacagtgtac tggttgtggc caaagtggag aaagggaagt ctaaaaaact caaaagcgtc     3480

aaggaactgc tgggcatcac aatcatggag cgatcaagct tcgaaaaaaa ccccatcgac     3540

tttctcgagg cgaaaggata taaagaggtc aaaaaagacc tcatcattaa gcttcccaag     3600

tactctctct ttgagcttga aaacggccgg aaacgaatgc tcgctagtgc gggcgagctg     3660

cagaaaggta acgagctggc actgccctct aaatacgtta atttcttgta tctggccagc     3720

cactatgaaa agctcaaagg gtctcccgaa gataatgagc agaagcagct gttcgtggaa     3780

caacacaaac actaccttga tgagatcatc gagcaaataa gcgaattctc caaaagagtg     3840

atcctcgccg acgctaacct cgataaggtg ctttctgctt acaataagca cagggataag     3900

cccatcaggg agcaggcaga aaacattatc cacttgttta ctctgaccaa cttgggcgcg     3960

cctgcagcct tcaagtactt cgacaccacc atagacagaa agcggtacac ctctacaaag     4020

gaggtcctgg acgccacact gattcatcag tcaattacgg ggctctatga aacaagaatc     4080

gacctctctc agctcggtgg agacgcggcc gcagatccaa aaaagaagag aaaggtagat     4140

ccaaaaaaga agagaaaggt agatccaaaa aagaagagaa aggtagatac ggccgcatag     4200


<210> 6
<211> 4326
<212> DNA
<213> Streptococcus pyogenes

<400> 6
atggacaaga agtactccat tgggctcgct atcggcacaa acagcgtcgg ctgggccgtc       60

attacggacg agtacaaggt gccgagcaaa aaattcaaag ttctgggcaa taccgatcgc      120

cacagcataa agaagaacct cattggcgcc ctcctgttcg actccgggga gacggccgaa      180

gccacgcggc tcaaaagaac agcacggcgc agatataccc gcagaaagaa tcggatctgc      240

tacctgcagg agatctttag taatgagatg gctaaggtgg atgactcttt cttccatagg      300

ctggaggagt cctttttggt ggaggaggat aaaaagcacg agcgccaccc aatctttggc      360

aatatcgtgg acgaggtggc gtaccatgaa aagtacccaa ccatatatca tctgaggaag      420

aagcttgtag acagtactga taaggctgac ttgcggttga tctatctcgc gctggcgcat      480

atgatcaaat ttcggggaca cttcctcatc gagggggacc tgaacccaga caacagcgat      540

gtcgacaaac tctttatcca actggttcag acttacaatc agcttttcga agagaacccg      600

atcaacgcat ccggagttga cgccaaagca atcctgagcg ctaggctgtc caaatcccgg      660

cggctcgaaa acctcatcgc acagctccct ggggagaaga agaacggcct gtttggtaat      720

cttatcgccc tgtcactcgg gctgaccccc aactttaaat ctaacttcga cctggccgaa      780

gatgccaagc ttcaactgag caaagacacc tacgatgatg atctcgacaa tctgctggcc      840

cagatcggcg accagtacgc agaccttttt ttggcggcaa agaacctgtc agacgccatt      900

ctgctgagtg atattctgcg agtgaacacg gagatcacca aagctccgct gagcgctagt      960

atgatcaagc gctatgatga gcaccaccaa gacttgactt tgctgaaggc ccttgtcaga     1020

cagcaactgc ctgagaagta caaggaaatt ttcttcgatc agtctaaaaa tggctacgcc     1080

ggatacattg acggcggagc aagccaggag gaattttaca aatttattaa gcccatcttg     1140

gaaaaaatgg acggcaccga ggagctgctg gtaaagctta acagagaaga tctgttgcgc     1200

aaacagcgca ctttcgacaa tggaagcatc ccccaccaga ttcacctggg cgaactgcac     1260

gctatcctca ggcggcaaga ggatttctac ccctttttga aagataacag ggaaaagatt     1320

gagaaaatcc tcacatttcg gataccctac tatgtaggcc ccctcgcccg gggaaattcc     1380

agattcgcgt ggatgactcg caaatcagaa gagaccatca ctccctggaa cttcgaggaa     1440

gtcgtggata agggggcctc tgcccagtcc ttcatcgaaa ggatgactaa ctttgataaa     1500

aatctgccta acgaaaaggt gcttcctaaa cactctctgc tgtacgagta cttcacagtt     1560

tataacgagc tcaccaaggt caaatacgtc acagaaggga tgagaaagcc agcattcctg     1620

tctggagagc agaagaaagc tatcgtggac ctcctcttca agacgaaccg gaaagttacc     1680

gtgaaacagc tcaaagaaga ctatttcaaa aagattgaat gtttcgactc tgttgaaatc     1740

agcggagtgg aggatcgctt caacgcatcc ctgggaacgt atcacgatct cctgaaaatc     1800

attaaagaca aggacttcct ggacaatgag gagaacgagg acattcttga ggacattgtc     1860

ctcaccctta cgttgtttga agatagggag atgattgaag aacgcttgaa aacttacgct     1920

catctcttcg acgacaaagt catgaaacag ctcaagaggc gccgatatac aggatggggg     1980

cggctgtcaa gaaaactgat caatgggatc cgagacaagc agagtggaaa gacaatcctg     2040

gattttctta agtccgatgg atttgccaac cggaacttca tgcagttgat ccatgatgac     2100

tctctcacct ttaaggagga catccagaaa gcacaagttt ctggccaggg ggacagtctt     2160

cacgagcaca tcgctaatct tgcaggtagc ccagctatca aaaagggaat actgcagacc     2220

gttaaggtcg tggatgaact cgtcaaagta atgggaaggc ataagcccga gaatatcgtt     2280

atcgagatgg cccgagagaa ccaaactacc cagaagggac agaagaacag tagggaaagg     2340

atgaagagga ttgaagaggg tataaaagaa ctggggtccc aaatccttaa ggaacaccca     2400

gttgaaaaca cccagcttca gaatgagaag ctctacctgt actacctgca gaacggcagg     2460

gacatgtacg tggatcagga actggacatc aatcggctct ccgactacga cgtggctgct     2520

atcgtgcccc agtcttttct caaagatgat tctattgata ataaagtgtt gacaagatcc     2580

gataaagcta gagggaagag tgataacgtc ccctcagaag aagttgtcaa gaaaatgaaa     2640

aattattggc ggcagctgct gaacgccaaa ctgatcacac aacggaagtt cgataatctg     2700

actaaggctg aacgaggtgg cctgtctgag ttggataaag ccggcttcat caaaaggcag     2760

cttgttgaga cacgccagat caccaagcac gtggcccaaa ttctcgattc acgcatgaac     2820

accaagtacg atgaaaatga caaactgatt cgagaggtga aagttattac tctgaagtct     2880

aagctggtct cagatttcag aaaggacttt cagttttata aggtgagaga gatcaacaat     2940

taccaccatg cgcatgatgc ctacctgaat gcagtggtag gcactgcact tatcaaaaaa     3000

tatcccaagc ttgaatctga atttgtttac ggagactata aagtgtacga tgttaggaaa     3060

atgatcgcaa agtctgagca ggaaataggc aaggccaccg ctaagtactt cttttacagc     3120

aatattatga attttttcaa gaccgagatt acactggcca atggagagat tcggaagcga     3180

ccacttatcg aaacaaacgg agaaacagga gaaatcgtgt gggacaaggg tagggatttc     3240

gcgacagtcc ggaaggtcct gtccatgccg caggtgaaca tcgttaaaaa gaccgaagta     3300

cagaccggag gcttctccaa ggaaagtatc ctcccgaaaa ggaacagcga caagctgatc     3360

gcacgcaaaa aagattggga ccccaagaaa tacggcggat tcgattctcc tacagtcgct     3420

tacagtgtac tggttgtggc caaagtggag aaagggaagt ctaaaaaact caaaagcgtc     3480

aaggaactgc tgggcatcac aatcatggag cgatcaagct tcgaaaaaaa ccccatcgac     3540

tttctcgagg cgaaaggata taaagaggtc aaaaaagacc tcatcattaa gcttcccaag     3600

tactctctct ttgagcttga aaacggccgg aaacgaatgc tcgctagtgc gggcgagctg     3660

cagaaaggta acgagctggc actgccctct aaatacgtta atttcttgta tctggccagc     3720

cactatgaaa agctcaaagg gtctcccgaa gataatgagc agaagcagct gttcgtggaa     3780

caacacaaac actaccttga tgagatcatc gagcaaataa gcgaattctc caaaagagtg     3840

atcctcgccg acgctaacct cgataaggtg ctttctgctt acaataagca cagggataag     3900

cccatcaggg agcaggcaga aaacattatc cacttgttta ctctgaccaa cttgggcgcg     3960

cctgcagcct tcaagtactt cgacaccacc atagacagaa agcggtacac ctctacaaag     4020

gaggtcctgg acgccacact gattcatcag tcaattacgg ggctctatga aacaagaatc     4080

gacctctctc agctcggtgg agacagcagg gctgacccca agaagaagag gaaggtggag     4140

gccagcggtt ccggacgggc tgacgcattg gacgattttg atctggatat gctgggaagt     4200

gacgccctcg atgattttga ccttgacatg cttggttcgg atgcccttga tgactttgac     4260

ctcgacatgc tcggcagtga cgcccttgat gatttcgacc tggacatgct gattaactct     4320

agatga                                                                4326


<210> 7
<211> 4359
<212> DNA
<213> Streptococcus pyogenes

<400> 7
atgcccaaga agaagaggaa ggtgggaagg gggatggaca agaagtactc cattgggctc       60

gctatcggca caaacagcgt cggctgggcc gtcattacgg acgagtacaa ggtgccgagc      120

aaaaaattca aagttctggg caataccgat cgccacagca taaagaagaa cctcattggc      180

gccctcctgt tcgactccgg ggagacggcc gaagccacgc ggctcaaaag aacagcacgg      240

cgcagatata cccgcagaaa gaatcggatc tgctacctgc aggagatctt tagtaatgag      300

atggctaagg tggatgactc tttcttccat aggctggagg agtccttttt ggtggaggag      360

gataaaaagc acgagcgcca cccaatcttt ggcaatatcg tggacgaggt ggcgtaccat      420

gaaaagtacc caaccatata tcatctgagg aagaagcttg tagacagtac tgataaggct      480

gacttgcggt tgatctatct cgcgctggcg catatgatca aatttcgggg acacttcctc      540

atcgaggggg acctgaaccc agacaacagc gatgtcgaca aactctttat ccaactggtt      600

cagacttaca atcagctttt cgaagagaac ccgatcaacg catccggagt tgacgccaaa      660

gcaatcctga gcgctaggct gtccaaatcc cggcggctcg aaaacctcat cgcacagctc      720

cctggggaga agaagaacgg cctgtttggt aatcttatcg ccctgtcact cgggctgacc      780

cccaacttta aatctaactt cgacctggcc gaagatgcca agcttcaact gagcaaagac      840

acctacgatg atgatctcga caatctgctg gcccagatcg gcgaccagta cgcagacctt      900

tttttggcgg caaagaacct gtcagacgcc attctgctga gtgatattct gcgagtgaac      960

acggagatca ccaaagctcc gctgagcgct agtatgatca agcgctatga tgagcaccac     1020

caagacttga ctttgctgaa ggcccttgtc agacagcaac tgcctgagaa gtacaaggaa     1080

attttcttcg atcagtctaa aaatggctac gccggataca ttgacggcgg agcaagccag     1140

gaggaatttt acaaatttat taagcccatc ttggaaaaaa tggacggcac cgaggagctg     1200

ctggtaaagc ttaacagaga agatctgttg cgcaaacagc gcactttcga caatggaagc     1260

atcccccacc agattcacct gggcgaactg cacgctatcc tcaggcggca agaggatttc     1320

tacccctttt tgaaagataa cagggaaaag attgagaaaa tcctcacatt tcggataccc     1380

tactatgtag gccccctcgc ccggggaaat tccagattcg cgtggatgac tcgcaaatca     1440

gaagagacca tcactccctg gaacttcgag gaagtcgtgg ataagggggc ctctgcccag     1500

tccttcatcg aaaggatgac taactttgat aaaaatctgc ctaacgaaaa ggtgcttcct     1560

aaacactctc tgctgtacga gtacttcaca gtttataacg agctcaccaa ggtcaaatac     1620

gtcacagaag ggatgagaaa gccagcattc ctgtctggag agcagaagaa agctatcgtg     1680

gacctcctct tcaagacgaa ccggaaagtt accgtgaaac agctcaaaga agactatttc     1740

aaaaagattg aatgtttcga ctctgttgaa atcagcggag tggaggatcg cttcaacgca     1800

tccctgggaa cgtatcacga tctcctgaaa atcattaaag acaaggactt cctggacaat     1860

gaggagaacg aggacattct tgaggacatt gtcctcaccc ttacgttgtt tgaagatagg     1920

gagatgattg aagaacgctt gaaaacttac gctcatctct tcgacgacaa agtcatgaaa     1980

cagctcaaga ggcgccgata tacaggatgg gggcggctgt caagaaaact gatcaatggg     2040

atccgagaca agcagagtgg aaagacaatc ctggattttc ttaagtccga tggatttgcc     2100

aaccggaact tcatgcagtt gatccatgat gactctctca cctttaagga ggacatccag     2160

aaagcacaag tttctggcca gggggacagt cttcacgagc acatcgctaa tcttgcaggt     2220

agcccagcta tcaaaaaggg aatactgcag accgttaagg tcgtggatga actcgtcaaa     2280

gtaatgggaa ggcataagcc cgagaatatc gttatcgaga tggcccgaga gaaccaaact     2340

acccagaagg gacagaagaa cagtagggaa aggatgaaga ggattgaaga gggtataaaa     2400

gaactggggt cccaaatcct taaggaacac ccagttgaaa acacccagct tcagaatgag     2460

aagctctacc tgtactacct gcagaacggc agggacatgt acgtggatca ggaactggac     2520

atcaatcggc tctccgacta cgacgtggct gctatcgtgc cccagtcttt tctcaaagat     2580

gattctattg ataataaagt gttgacaaga tccgataaag ctagagggaa gagtgataac     2640

gtcccctcag aagaagttgt caagaaaatg aaaaattatt ggcggcagct gctgaacgcc     2700

aaactgatca cacaacggaa gttcgataat ctgactaagg ctgaacgagg tggcctgtct     2760

gagttggata aagccggctt catcaaaagg cagcttgttg agacacgcca gatcaccaag     2820

cacgtggccc aaattctcga ttcacgcatg aacaccaagt acgatgaaaa tgacaaactg     2880

attcgagagg tgaaagttat tactctgaag tctaagctgg tctcagattt cagaaaggac     2940

tttcagtttt ataaggtgag agagatcaac aattaccacc atgcgcatga tgcctacctg     3000

aatgcagtgg taggcactgc acttatcaaa aaatatccca agcttgaatc tgaatttgtt     3060

tacggagact ataaagtgta cgatgttagg aaaatgatcg caaagtctga gcaggaaata     3120

ggcaaggcca ccgctaagta cttcttttac agcaatatta tgaatttttt caagaccgag     3180

attacactgg ccaatggaga gattcggaag cgaccactta tcgaaacaaa cggagaaaca     3240

ggagaaatcg tgtgggacaa gggtagggat ttcgcgacag tccggaaggt cctgtccatg     3300

ccgcaggtga acatcgttaa aaagaccgaa gtacagaccg gaggcttctc caaggaaagt     3360

atcctcccga aaaggaacag cgacaagctg atcgcacgca aaaaagattg ggaccccaag     3420

aaatacggcg gattcgattc tcctacagtc gcttacagtg tactggttgt ggccaaagtg     3480

gagaaaggga agtctaaaaa actcaaaagc gtcaaggaac tgctgggcat cacaatcatg     3540

gagcgatcaa gcttcgaaaa aaaccccatc gactttctcg aggcgaaagg atataaagag     3600

gtcaaaaaag acctcatcat taagcttccc aagtactctc tctttgagct tgaaaacggc     3660

cggaaacgaa tgctcgctag tgcgggcgag ctgcagaaag gtaacgagct ggcactgccc     3720

tctaaatacg ttaatttctt gtatctggcc agccactatg aaaagctcaa agggtctccc     3780

gaagataatg agcagaagca gctgttcgtg gaacaacaca aacactacct tgatgagatc     3840

atcgagcaaa taagcgaatt ctccaaaaga gtgatcctcg ccgacgctaa cctcgataag     3900

gtgctttctg cttacaataa gcacagggat aagcccatca gggagcaggc agaaaacatt     3960

atccacttgt ttactctgac caacttgggc gcgcctgcag ccttcaagta cttcgacacc     4020

accatagaca gaaagcggta cacctctaca aaggaggtcc tggacgccac actgattcat     4080

cagtcaatta cggggctcta tgaaacaaga atcgacctct ctcagctcgg tggagacagc     4140

agggctgacc ccaagaagaa gaggaaggtg gaggccagcg gttccggacg ggctgacgca     4200

ttggacgatt ttgatctgga tatgctggga agtgacgccc tcgatgattt tgaccttgac     4260

atgcttggtt cggatgccct tgatgacttt gacctcgaca tgctcggcag tgacgccctt     4320

gatgatttcg acctggacat gctgattaac tctagatga                            4359


<210> 8
<211> 1409
<212> PRT
<213> Streptococcus thermophiles

<400> 8
Met Leu Phe Asn Lys Cys Ile Ile Ile Ser Ile Asn Leu Asp Phe Ser 
1               5                   10                  15      


Asn Lys Glu Lys Cys Met Thr Lys Pro Tyr Ser Ile Gly Leu Asp Ile 
            20                  25                  30          


Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Asn Tyr Lys Val 
        35                  40                  45              


Pro Ser Lys Lys Met Lys Val Leu Gly Asn Thr Ser Lys Lys Tyr Ile 
    50                  55                  60                  


Lys Lys Asn Leu Leu Gly Val Leu Leu Phe Asp Ser Gly Ile Thr Ala 
65                  70                  75                  80  


Glu Gly Arg Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg 
                85                  90                  95      


Arg Asn Arg Ile Leu Tyr Leu Gln Glu Ile Phe Ser Thr Glu Met Ala 
            100                 105                 110         


Thr Leu Asp Asp Ala Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val 
        115                 120                 125             


Pro Asp Asp Lys Arg Asp Ser Lys Tyr Pro Ile Phe Gly Asn Leu Val 
    130                 135                 140                 


Glu Glu Lys Val Tyr His Asp Glu Phe Pro Thr Ile Tyr His Leu Arg 
145                 150                 155                 160 


Lys Tyr Leu Ala Asp Ser Thr Lys Lys Ala Asp Leu Arg Leu Val Tyr 
                165                 170                 175     


Leu Ala Leu Ala His Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu 
            180                 185                 190         


Gly Glu Phe Asn Ser Lys Asn Asn Asp Ile Gln Lys Asn Phe Gln Asp 
        195                 200                 205             


Phe Leu Asp Thr Tyr Asn Ala Ile Phe Glu Ser Asp Leu Ser Leu Glu 
    210                 215                 220                 


Asn Ser Lys Gln Leu Glu Glu Ile Val Lys Asp Lys Ile Ser Lys Leu 
225                 230                 235                 240 


Glu Lys Lys Asp Arg Ile Leu Lys Leu Phe Pro Gly Glu Lys Asn Ser 
                245                 250                 255     


Gly Ile Phe Ser Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp 
            260                 265                 270         


Phe Arg Lys Cys Phe Asn Leu Asp Glu Lys Ala Ser Leu His Phe Ser 
        275                 280                 285             


Lys Glu Ser Tyr Asp Glu Asp Leu Glu Thr Leu Leu Gly Tyr Ile Gly 
    290                 295                 300                 


Asp Asp Tyr Ser Asp Val Phe Leu Lys Ala Lys Lys Leu Tyr Asp Ala 
305                 310                 315                 320 


Ile Leu Leu Ser Gly Phe Leu Thr Val Thr Asp Asn Glu Thr Glu Ala 
                325                 330                 335     


Pro Leu Ser Ser Ala Met Ile Lys Arg Tyr Asn Glu His Lys Glu Asp 
            340                 345                 350         


Leu Ala Leu Leu Lys Glu Tyr Ile Arg Asn Ile Ser Leu Lys Thr Tyr 
        355                 360                 365             


Asn Glu Val Phe Lys Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Ile 
    370                 375                 380                 


Asp Gly Lys Thr Asn Gln Glu Asp Phe Tyr Val Tyr Leu Lys Asn Leu 
385                 390                 395                 400 


Leu Ala Glu Phe Glu Gly Ala Asp Tyr Phe Leu Glu Lys Ile Asp Arg 
                405                 410                 415     


Glu Asp Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro 
            420                 425                 430         


Tyr Gln Ile His Leu Gln Glu Met Arg Ala Ile Leu Asp Lys Gln Ala 
        435                 440                 445             


Lys Phe Tyr Pro Phe Leu Ala Lys Asn Lys Glu Arg Ile Glu Lys Ile 
    450                 455                 460                 


Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn 
465                 470                 475                 480 


Ser Asp Phe Ala Trp Ser Ile Arg Lys Arg Asn Glu Lys Ile Thr Pro 
                485                 490                 495     


Trp Asn Phe Glu Asp Val Ile Asp Lys Glu Ser Ser Ala Glu Ala Phe 
            500                 505                 510         


Ile Asn Arg Met Thr Ser Phe Asp Leu Tyr Leu Pro Glu Glu Lys Val 
        515                 520                 525             


Leu Pro Lys His Ser Leu Leu Tyr Glu Thr Phe Asn Val Tyr Asn Glu 
    530                 535                 540                 


Leu Thr Lys Val Arg Phe Ile Ala Glu Ser Met Arg Asp Tyr Gln Phe 
545                 550                 555                 560 


Leu Asp Ser Lys Gln Lys Lys Asp Ile Val Arg Leu Tyr Phe Lys Asp 
                565                 570                 575     


Lys Arg Lys Val Thr Asp Lys Asp Ile Ile Glu Tyr Leu His Ala Ile 
            580                 585                 590         


Tyr Gly Tyr Asp Gly Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn 
        595                 600                 605             


Ser Ser Leu Ser Thr Tyr His Asp Leu Leu Asn Ile Ile Asn Asp Lys 
    610                 615                 620                 


Glu Phe Leu Asp Asp Ser Ser Asn Glu Ala Ile Ile Glu Glu Ile Ile 
625                 630                 635                 640 


His Thr Leu Thr Ile Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu 
                645                 650                 655     


Ser Lys Phe Glu Asn Ile Phe Asp Lys Ser Val Leu Lys Lys Leu Ser 
            660                 665                 670         


Arg Arg His Tyr Thr Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn 
        675                 680                 685             


Gly Ile Arg Asp Glu Lys Ser Gly Asn Thr Ile Leu Asp Tyr Leu Ile 
    690                 695                 700                 


Asp Asp Gly Ile Ser Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
705                 710                 715                 720 


Ala Leu Ser Phe Lys Lys Lys Ile Gln Lys Ala Gln Ile Ile Gly Asp 
                725                 730                 735     


Glu Asp Lys Gly Asn Ile Lys Glu Val Val Lys Ser Leu Pro Gly Ser 
            740                 745                 750         


Pro Ala Ile Lys Lys Gly Ile Leu Gln Ser Ile Lys Ile Val Asp Glu 
        755                 760                 765             


Leu Val Lys Val Met Gly Gly Arg Lys Pro Glu Ser Ile Val Val Glu 
    770                 775                 780                 


Met Ala Arg Glu Asn Gln Tyr Thr Asn Gln Gly Lys Ser Asn Ser Gln 
785                 790                 795                 800 


Gln Arg Leu Lys Arg Leu Glu Lys Ser Leu Lys Glu Leu Gly Ser Lys 
                805                 810                 815     


Ile Leu Lys Glu Asn Ile Pro Ala Lys Leu Ser Lys Ile Asp Asn Asn 
            820                 825                 830         


Ala Leu Gln Asn Asp Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Lys 
        835                 840                 845             


Asp Met Tyr Thr Gly Asp Asp Leu Asp Ile Asp Arg Leu Ser Asn Tyr 
    850                 855                 860                 


Asp Ile Asp His Ile Ile Pro Gln Ala Phe Leu Lys Asp Asn Ser Ile 
865                 870                 875                 880 


Asp Asn Lys Val Leu Val Ser Ser Ala Ser Asn Arg Gly Lys Ser Asp 
                885                 890                 895     


Asp Phe Pro Ser Leu Glu Val Val Lys Lys Arg Lys Thr Phe Trp Tyr 
            900                 905                 910         


Gln Leu Leu Lys Ser Lys Leu Ile Ser Gln Arg Lys Phe Asp Asn Leu 
        915                 920                 925             


Thr Lys Ala Glu Arg Gly Gly Leu Leu Pro Glu Asp Lys Ala Gly Phe 
    930                 935                 940                 


Ile Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala 
945                 950                 955                 960 


Arg Leu Leu Asp Glu Lys Phe Asn Asn Lys Lys Asp Glu Asn Asn Arg 
                965                 970                 975     


Ala Val Arg Thr Val Lys Ile Ile Thr Leu Lys Ser Thr Leu Val Ser 
            980                 985                 990         


Gln Phe Arg Lys Asp Phe Glu Leu  Tyr Lys Val Arg Glu  Ile Asn Asp 
        995                 1000                 1005             


Phe His  His Ala His Asp Ala  Tyr Leu Asn Ala Val  Ile Ala Ser 
    1010                 1015                 1020             


Ala Leu  Leu Lys Lys Tyr Pro  Lys Leu Glu Pro Glu  Phe Val Tyr 
    1025                 1030                 1035             


Gly Asp  Tyr Pro Lys Tyr Asn  Ser Phe Arg Glu Arg  Lys Ser Ala 
    1040                 1045                 1050             


Thr Glu  Lys Val Tyr Phe Tyr  Ser Asn Ile Met Asn  Ile Phe Lys 
    1055                 1060                 1065             


Lys Ser  Ile Ser Leu Ala Asp  Gly Arg Val Ile Glu  Arg Pro Leu 
    1070                 1075                 1080             


Ile Glu  Val Asn Glu Glu Thr  Gly Glu Ser Val Trp  Asn Lys Glu 
    1085                 1090                 1095             


Ser Asp  Leu Ala Thr Val Arg  Arg Val Leu Ser Tyr  Pro Gln Val 
    1100                 1105                 1110             


Asn Val  Val Lys Lys Val Glu  Glu Gln Asn His Gly  Leu Asp Arg 
    1115                 1120                 1125             


Gly Lys  Pro Lys Gly Leu Phe  Asn Ala Asn Leu Ser  Ser Lys Pro 
    1130                 1135                 1140             


Lys Pro  Asn Ser Asn Glu Asn  Leu Val Gly Ala Lys  Glu Tyr Leu 
    1145                 1150                 1155             


Asp Pro  Lys Lys Tyr Gly Gly  Tyr Ala Gly Ile Ser  Asn Ser Phe 
    1160                 1165                 1170             


Ala Val  Leu Val Lys Gly Thr  Ile Glu Lys Gly Ala  Lys Lys Lys 
    1175                 1180                 1185             


Ile Thr  Asn Val Leu Glu Phe  Gln Gly Ile Ser Ile  Leu Asp Arg 
    1190                 1195                 1200             


Ile Asn  Tyr Arg Lys Asp Lys  Leu Asn Phe Leu Leu  Glu Lys Gly 
    1205                 1210                 1215             


Tyr Lys  Asp Ile Glu Leu Ile  Ile Glu Leu Pro Lys  Tyr Ser Leu 
    1220                 1225                 1230             


Phe Glu  Leu Ser Asp Gly Ser  Arg Arg Met Leu Ala  Ser Ile Leu 
    1235                 1240                 1245             


Ser Thr  Asn Asn Lys Arg Gly  Glu Ile His Lys Gly  Asn Gln Ile 
    1250                 1255                 1260             


Phe Leu  Ser Gln Lys Phe Val  Lys Leu Leu Tyr His  Ala Lys Arg 
    1265                 1270                 1275             


Ile Ser  Asn Thr Ile Asn Glu  Asn His Arg Lys Tyr  Val Glu Asn 
    1280                 1285                 1290             


His Lys  Lys Glu Phe Glu Glu  Leu Phe Tyr Tyr Ile  Leu Glu Phe 
    1295                 1300                 1305             


Asn Glu  Asn Tyr Val Gly Ala  Lys Lys Asn Gly Lys  Leu Leu Asn 
    1310                 1315                 1320             


Ser Ala  Phe Gln Ser Trp Gln  Asn His Ser Ile Asp  Glu Leu Cys 
    1325                 1330                 1335             


Ser Ser  Phe Ile Gly Pro Thr  Gly Ser Glu Arg Lys  Gly Leu Phe 
    1340                 1345                 1350             


Glu Leu  Thr Ser Arg Gly Ser  Ala Ala Asp Phe Glu  Phe Leu Gly 
    1355                 1360                 1365             


Val Lys  Ile Pro Arg Tyr Arg  Asp Tyr Thr Pro Ser  Ser Leu Leu 
    1370                 1375                 1380             


Lys Asp  Ala Thr Leu Ile His  Gln Ser Val Thr Gly  Leu Tyr Glu 
    1385                 1390                 1395             


Thr Arg  Ile Asp Leu Ala Lys  Leu Gly Glu Gly 
    1400                 1405                 


<210> 9
<211> 4167
<212> DNA
<213> Streptococcus thermophiles

<400> 9
atgactaagc catactcaat tggacttgat attggaacga atagtgttgg atgggctgta       60

ataactgata attacaaggt tccgtctaaa aaaatgaaag tcttaggaaa tacgagtaaa      120

aagtatatca aaaagaacct gttaggtgta ttactctttg actctggaat cacagcagaa      180

ggaagaagat tgaagcgtac tgcaagaaga cgttatacta gacgccgtaa tcgtatcctt      240

tatttgcagg aaatttttag cacggagatg gctacattag atgatgcttt ctttcaaaga      300

cttgacgatt cgtttttagt tcctgatgat aaacgtgata gtaagtatcc gatatttgga      360

aacttagtag aagaaaaagt ctatcatgat gaatttccaa ctatctatca tttaaggaaa      420

tatttagcag atagtactaa aaaagcagat ttgcgtctag tttatcttgc attggctcat      480

atgattaaat atagaggtca cttcttaatt gaaggagagt ttaattcaaa aaataatgat      540

attcagaaga attttcaaga ctttttggac acttataatg ctatttttga atcggattta      600

tcacttgaga atagtaaaca acttgaggaa attgttaaag ataagattag taaattagaa      660

aagaaagatc gtattttaaa actcttccct ggggagaaga attcggggat tttttcagag      720

tttctaaagt tgattgtagg aaatcaagct gattttagga aatgttttaa tttagacgaa      780

aaagcctcct tacatttttc caaagaaagc tatgatgaag atttagagac tttgttaggt      840

tatattggag atgattacag tgatgtcttt ctcaaagcaa agaaacttta tgatgctatt      900

cttttatcgg gttttctgac tgtaactgat aatgagacag aagcacctct ctcttctgct      960

atgataaagc gatataatga acacaaagaa gatttagcgt tactaaagga atatataaga     1020

aatatttcac taaaaacgta taatgaagta tttaaagatg acaccaaaaa tggttatgct     1080

ggttatattg atggaaaaac aaatcaggaa gatttctacg tatatctaaa aaacctattg     1140

gctgaatttg aaggtgcgga ttattttctt gaaaaaattg atcgagaaga ttttttgaga     1200

aagcaacgta catttgacaa tggttcgata ccatatcaga ttcatcttca agaaatgaga     1260

gcaattcttg ataagcaagc taaattttat cctttcttgg ctaaaaataa agaaagaatc     1320

gagaagattt taaccttccg aattccttat tatgtaggtc cacttgcgag agggaatagt     1380

gattttgcct ggtcaataag aaaacgaaat gaaaaaatta caccttggaa ttttgaggac     1440

gttattgaca aagaatcttc ggcagaggct ttcattaatc gaatgactag ttttgatttg     1500

tatttgccag aagagaaggt acttccaaag catagtctct tatacgaaac ttttaatgta     1560

tataatgaat taacaaaagt tagatttatt gccgaaagta tgagagatta tcaattttta     1620

gatagtaagc agaagaaaga tattgttaga ctttatttta aagataaaag gaaagttact     1680

gataaggata ttattgaata tttacatgca atttatgggt atgatggaat tgaattaaaa     1740

ggcatagaga aacagtttaa ttctagttta tctacttatc acgatctttt aaatattatt     1800

aatgataaag agtttttgga tgatagttca aatgaagcga ttatcgaaga aattatccat     1860

actttgacaa tttttgaaga tagagagatg ataaaacaac gtctttcaaa atttgagaat     1920

atattcgata aatccgtttt gaaaaagtta tctcgtagac attacactgg ctggggtaag     1980

ttatctgcta agcttattaa tggtattcga gatgaaaaat ctggtaatac tattcttgat     2040

tacttaattg atgatggtat ttctaaccgt aatttcatgc aacttattca cgatgatgct     2100

ctttctttta aaaagaagat acagaaagca caaattattg gtgacgaaga taaaggtaat     2160

attaaagagg tcgttaagtc tttgccaggt agtcctgcga ttaaaaaagg tattttacaa     2220

agcataaaaa ttgtagatga attggtcaaa gtaatgggag gaagaaaacc cgagtcaatt     2280

gttgttgaga tggctcgtga aaatcaatat accaatcaag gtaagtctaa ttcccaacaa     2340

cgcttgaaac gtttagaaaa atctctcaaa gagttaggta gtaagatact taaggaaaat     2400

attcctgcaa aactttctaa aatagacaat aacgcacttc aaaatgatcg actttactta     2460

tactatcttc aaaatggaaa agatatgtat accggagatg atttagatat tgatagatta     2520

agtaattatg atattgatca tattattcct caagcttttt tgaaagataa ttctattgac     2580

aataaagtac ttgtttcatc tgctagtaac cgtggtaaat cagatgattt tccaagttta     2640

gaggttgtca aaaaaagaaa gacattttgg tatcaattat tgaaatcaaa attaatttct     2700

caacgaaaat ttgataatct gacaaaagct gaacggggag gattgttacc tgaggacaaa     2760

gctggtttta ttcaacgcca gttggttgaa acacgtcaaa taacaaaaca tgtagctcgt     2820

ttacttgatg agaaatttaa taataaaaaa gatgaaaata atagagcggt acgaacagta     2880

aaaattatta ccttgaaatc taccttagtt tctcaatttc gtaaggattt tgaactttat     2940

aaagttcgtg aaatcaatga ttttcatcat gctcatgatg cttacttgaa tgccgttata     3000

gcaagtgctt tacttaagaa ataccctaaa ctagagccag aatttgtgta cggtgattat     3060

ccaaaataca atagttttag agaaagaaag tccgctacag aaaaggtata tttctattca     3120

aatatcatga atatctttaa aaaatctatt tctttagctg atggtagagt tattgaaaga     3180

ccacttattg aggtaaatga ggagaccggc gaatccgttt ggaataaaga atctgattta     3240

gcaactgtaa ggagagtact ctcttatccg caagtaaatg ttgtgaaaaa agttgaggaa     3300

cagaatcacg gattggatag aggaaaacca aagggattgt ttaatgcaaa tctttcctca     3360

aagccaaaac caaatagtaa tgaaaattta gtaggtgcta aagagtatct tgaccccaaa     3420

aagtatgggg ggtatgctgg aatttctaat tcttttgctg ttcttgttaa agggacaatt     3480

gaaaaaggtg ctaagaaaaa aataacaaat gtactagaat ttcaaggtat ttctatttta     3540

gataggatta attatagaaa agataaactt aattttttac ttgaaaaagg ttataaagat     3600

attgagttaa ttattgaact acctaaatat agtttatttg aactttcaga tggttcacgt     3660

cgtatgttgg ctagtatttt gtcaacgaat aataagaggg gagagattca caaaggaaat     3720

cagatttttc tttcacagaa gtttgtgaaa ttactttatc atgctaagag aataagtaac     3780

acaattaatg agaatcatag aaaatatgtt gagaaccata aaaaagagtt tgaagaatta     3840

ttttactaca ttcttgagtt taatgagaat tatgttggag ctaaaaagaa tggtaaactt     3900

ttaaactctg cctttcaatc ttggcaaaat catagtatag atgaactctg tagtagtttt     3960

ataggaccta ccggaagtga aagaaagggg ctatttgaat taacctctcg tggaagtgct     4020

gctgattttg aatttttagg tgttaaaatt ccaaggtata gagactatac cccatcatcc     4080

ctattaaaag atgccacact tattcatcaa tctgttacag gcctctatga aacacgaata     4140

gaccttgcca aactaggaga gggttaa                                         4167


<210> 10
<211> 3366
<212> DNA
<213> Streptococcus thermophilus

<400> 10
atgagcgacc tggtgctggg cctggacatc ggcatcggca gcgtgggcgt gggcatcctg       60

aacaaggtga ccggcgagat catccacaag aacagtcgca tcttccctgc tgctcaggct      120

gagaacaacc tggtgcgccg caccaaccgc cagggtcgcc ggcttgctcg ccgcaagaag      180

caccggcgcg tgcgcctgaa ccgcctgttc gaggagagcg gcctgatcac cgacttcacc      240

aagatcagca tcaacctgaa cccctaccag ctgcgcgtga agggcctgac cgacgagctg      300

agcaacgagg agctgttcat cgccctgaag aacatggtga agcaccgcgg catcagctac      360

ctggacgacg ccagcgacga cggcaacagc agcgtgggcg actacgccca gatcgtgaag      420

gagaacagca agcagctgga gaccaagacc cccggccaga tccagctgga gcgctaccag      480

acctacggcc agctgcgcgg cgacttcacc gtggagaagg acggcaagaa gcaccgcctg      540

atcaacgtgt tccccaccag cgcctaccgc agcgaggccc tgcgcatcct gcagacccag      600

caggagttca acccccagat caccgacgag ttcatcaacc gctacctgga gatcctgacc      660

ggcaagcgca agtactacca cggccccggc aacgagaaga gccgcaccga ctacggccgc      720

taccgcacca gcggcgagac cctggacaac atcttcggca tcctgatcgg caagtgcacc      780

ttctaccccg acgagttccg cgccgccaag gccagctaca ccgcccagga gttcaacctg      840

ctgaacgacc tgaacaacct gaccgtgccc accgagacca agaagctgag caaggagcag      900

aagaaccaga tcatcaacta cgtgaagaac gagaaggcca tgggccccgc caagctgttc      960

aagtacatcg ccaagctgct gagctgcgac gtggccgaca tcaagggcta ccgcatcgac     1020

aagagcggca aggccgagat ccacaccttc gaggcctacc gcaagatgaa gaccctggag     1080

accctggaca tcgagcagat ggaccgcgag accctggaca agctggccta cgtgctgacc     1140

ctgaacaccg agcgcgaggg catccaggag gccctggagc acgagttcgc cgacggcagc     1200

ttcagccaga agcaggtgga cgagctggtg cagttccgca aggccaacag cagcatcttc     1260

ggcaagggct ggcacaactt cagcgtgaag ctgatgatgg agctgatccc cgagctgtac     1320

gagaccagcg aggagcagat gaccatcctg acccgcctgg gcaagcagaa gaccaccagc     1380

agcagcaaca agaccaagta catcgacgag aagctgctga ccgaggagat ctacaacccc     1440

gtggtggcca agagcgtgcg ccaggccatc aagatcgtga acgccgccat caaggagtac     1500

ggcgacttcg acaacatcgt gatcgagatg gcccgcgaga ccaacgagga cgacgagaag     1560

aaggccatcc agaagatcca gaaggccaac aaggacgaga aggacgccgc catgctgaag     1620

gccgccaacc agtacaacgg caaggccgag ctgccccaca gcgtgttcca cggccacaag     1680

cagctggcca ccaagatccg cctgtggcac cagcagggcg agcgctgcct gtacaccggc     1740

aagaccatca gcatccacga cctgatcaac aacagcaacc agttcgaggt ggaccacatc     1800

ctgcccctga gcatcacctt cgacgacagc ctggccaaca aggtgctggt gtacgccacc     1860

gccaaccagg agaagggcca gcgcaccccc taccaggccc tggacagcat ggacgacgcc     1920

tggagcttcc gcgagctgaa ggccttcgtg cgcgagagca agaccctgag caacaagaag     1980

aaggagtacc tgctgaccga ggaggacatc agcaagttcg acgtgcgcaa gaagttcatc     2040

gagcgcaacc tggtggacac ccgctacgcc agccgcgtgg tgctgaacgc cctgcaggag     2100

cacttccgcg cccacaagat cgacaccaag gtgagcgtgg tgcgcggcca gttcaccagc     2160

cagctgcgcc gccactgggg catcgagaag acccgcgaca cctaccacca ccacgccgtg     2220

gacgccctga tcattgcggc ttctagccag ctgaacctgt ggaagaagca gaagaacacc     2280

ctggtgagct acagcgagga ccagctgctg gacatcgaga ccggcgagct gatcagcgac     2340

gacgagtaca aggagagcgt gttcaaggcc ccctaccagc acttcgtgga caccctgaag     2400

agcaaggagt tcgaggacag catcctgttc agctaccagg tggacagcaa gttcaaccgc     2460

aagatcagcg acgccaccat ctacgccacc cgccaggcca aggtgggcaa ggacaaggcc     2520

gacgagacct acgtgctggg caagatcaag gacatctaca cccaggacgg ctacgacgcc     2580

ttcatgaaga tctacaagaa ggacaagagc aagttcctga tgtaccgcca cgacccccag     2640

accttcgaga aggtgatcga gcccatcctg gagaactacc ccaacaagca gatcaacgat     2700

aaaggcaagg aggtgccctg caaccccttc ctgaagtaca aggaggagca cggctacatc     2760

cgcaagtaca gcaagaaggg caacggcccc gagatcaaga gcctgaagta ctacgacagc     2820

aagctgggca accacatcga catcaccccc aaggacagca acaacaaggt ggtgctgcag     2880

agcgtgagcc cctggcgcgc cgacgtgtac ttcaacaaga ccaccggcaa gtacgagatc     2940

ctgggcctga agtacgccga cctgcagttt gataagggca ccggcaccta caagatcagc     3000

caggagaagt acaacgacat caagaagaag gagggcgtgg acagcgacag cgagttcaag     3060

ttcaccctgt acaagaacga ccttctgctg gtgaaggaca ccgagaccaa ggagcaacag     3120

ctgttccgct tcctgagccg caccatgccc aagcagaagc actacgtgga gctgaagccc     3180

tacgacaagc agaagttcga gggcggcgag gccctgatca aggtgctggg caacgtggcc     3240

aacagcggcc agtgcaagaa gggcctgggc aagagcaaca tcagcatcta caaggtgcgc     3300

accgacgtgc tgggcaacca gcacatcatc aagaacgagg gcgacaagcc caagctggac     3360

ttctaa                                                                3366


<210> 11
<211> 3366
<212> DNA
<213> Streptococcus thermophilus

<400> 11
atgagcgacc tggtgctggg cctggccatc ggcatcggca gcgtgggcgt gggcatcctg       60

aacaaggtga ccggcgagat catccacaag aacagtcgca tcttccctgc tgctcaggct      120

gagaacaacc tggtgcgccg caccaaccgc cagggtcgcc ggcttgctcg ccgcaagaag      180

caccggcgcg tgcgcctgaa ccgcctgttc gaggagagcg gcctgatcac cgacttcacc      240

aagatcagca tcaacctgaa cccctaccag ctgcgcgtga agggcctgac cgacgagctg      300

agcaacgagg agctgttcat cgccctgaag aacatggtga agcaccgcgg catcagctac      360

ctggacgacg ccagcgacga cggcaacagc agcgtgggcg actacgccca gatcgtgaag      420

gagaacagca agcagctgga gaccaagacc cccggccaga tccagctgga gcgctaccag      480

acctacggcc agctgcgcgg cgacttcacc gtggagaagg acggcaagaa gcaccgcctg      540

atcaacgtgt tccccaccag cgcctaccgc agcgaggccc tgcgcatcct gcagacccag      600

caggagttca acccccagat caccgacgag ttcatcaacc gctacctgga gatcctgacc      660

ggcaagcgca agtactacca cggccccggc aacgagaaga gccgcaccga ctacggccgc      720

taccgcacca gcggcgagac cctggacaac atcttcggca tcctgatcgg caagtgcacc      780

ttctaccccg acgagttccg cgccgccaag gccagctaca ccgcccagga gttcaacctg      840

ctgaacgacc tgaacaacct gaccgtgccc accgagacca agaagctgag caaggagcag      900

aagaaccaga tcatcaacta cgtgaagaac gagaaggcca tgggccccgc caagctgttc      960

aagtacatcg ccaagctgct gagctgcgac gtggccgaca tcaagggcta ccgcatcgac     1020

aagagcggca aggccgagat ccacaccttc gaggcctacc gcaagatgaa gaccctggag     1080

accctggaca tcgagcagat ggaccgcgag accctggaca agctggccta cgtgctgacc     1140

ctgaacaccg agcgcgaggg catccaggag gccctggagc acgagttcgc cgacggcagc     1200

ttcagccaga agcaggtgga cgagctggtg cagttccgca aggccaacag cagcatcttc     1260

ggcaagggct ggcacaactt cagcgtgaag ctgatgatgg agctgatccc cgagctgtac     1320

gagaccagcg aggagcagat gaccatcctg acccgcctgg gcaagcagaa gaccaccagc     1380

agcagcaaca agaccaagta catcgacgag aagctgctga ccgaggagat ctacaacccc     1440

gtggtggcca agagcgtgcg ccaggccatc aagatcgtga acgccgccat caaggagtac     1500

ggcgacttcg acaacatcgt gatcgagatg gcccgcgaga ccaacgagga cgacgagaag     1560

aaggccatcc agaagatcca gaaggccaac aaggacgaga aggacgccgc catgctgaag     1620

gccgccaacc agtacaacgg caaggccgag ctgccccaca gcgtgttcca cggccacaag     1680

cagctggcca ccaagatccg cctgtggcac cagcagggcg agcgctgcct gtacaccggc     1740

aagaccatca gcatccacga cctgatcaac aacagcaacc agttcgaggt ggctgccatc     1800

ctgcccctga gcatcacctt cgacgacagc ctggccaaca aggtgctggt gtacgccacc     1860

gccgctcagg agaagggcca gcgcaccccc taccaggccc tggacagcat ggacgacgcc     1920

tggagcttcc gcgagctgaa ggccttcgtg cgcgagagca agaccctgag caacaagaag     1980

aaggagtacc tgctgaccga ggaggacatc agcaagttcg acgtgcgcaa gaagttcatc     2040

gagcgcaacc tggtggacac ccgctacgcc agccgcgtgg tgctgaacgc cctgcaggag     2100

cacttccgcg cccacaagat cgacaccaag gtgagcgtgg tgcgcggcca gttcaccagc     2160

cagctgcgcc gccactgggg catcgagaag acccgcgaca cctaccacca ccacgccgtg     2220

gacgccctga tcattgcggc ttctagccag ctgaacctgt ggaagaagca gaagaacacc     2280

ctggtgagct acagcgagga ccagctgctg gacatcgaga ccggcgagct gatcagcgac     2340

gacgagtaca aggagagcgt gttcaaggcc ccctaccagc acttcgtgga caccctgaag     2400

agcaaggagt tcgaggacag catcctgttc agctaccagg tggacagcaa gttcaaccgc     2460

aagatcagcg acgccaccat ctacgccacc cgccaggcca aggtgggcaa ggacaaggcc     2520

gacgagacct acgtgctggg caagatcaag gacatctaca cccaggacgg ctacgacgcc     2580

ttcatgaaga tctacaagaa ggacaagagc aagttcctga tgtaccgcca cgacccccag     2640

accttcgaga aggtgatcga gcccatcctg gagaactacc ccaacaagca gatcaacgat     2700

aaaggcaagg aggtgccctg caaccccttc ctgaagtaca aggaggagca cggctacatc     2760

cgcaagtaca gcaagaaggg caacggcccc gagatcaaga gcctgaagta ctacgacagc     2820

aagctgggca accacatcga catcaccccc aaggacagca acaacaaggt ggtgctgcag     2880

agcgtgagcc cctggcgcgc cgacgtgtac ttcaacaaga ccaccggcaa gtacgagatc     2940

ctgggcctga agtacgccga cctgcagttt gataagggca ccggcaccta caagatcagc     3000

caggagaagt acaacgacat caagaagaag gagggcgtgg acagcgacag cgagttcaag     3060

ttcaccctgt acaagaacga ccttctgctg gtgaaggaca ccgagaccaa ggagcaacag     3120

ctgttccgct tcctgagccg caccatgccc aagcagaagc actacgtgga gctgaagccc     3180

tacgacaagc agaagttcga gggcggcgag gccctgatca aggtgctggg caacgtggcc     3240

aacagcggcc agtgcaagaa gggcctgggc aagagcaaca tcagcatcta caaggtgcgc     3300

accgacgtgc tgggcaacca gcacatcatc aagaacgagg gcgacaagcc caagctggac     3360

ttctaa                                                                3366


<210> 12
<211> 3399
<212> DNA
<213> Streptococcus thermophilus

<400> 12
atgagcgacc tggtgctggg cctggacatc ggcatcggca gcgtgggcgt gggcatcctg       60

aacaaggtga ccggcgagat catccacaag aacagtcgca tcttccctgc tgctcaggct      120

gagaacaacc tggtgcgccg caccaaccgc cagggtcgcc ggcttgctcg ccgcaagaag      180

caccggcgcg tgcgcctgaa ccgcctgttc gaggagagcg gcctgatcac cgacttcacc      240

aagatcagca tcaacctgaa cccctaccag ctgcgcgtga agggcctgac cgacgagctg      300

agcaacgagg agctgttcat cgccctgaag aacatggtga agcaccgcgg catcagctac      360

ctggacgacg ccagcgacga cggcaacagc agcgtgggcg actacgccca gatcgtgaag      420

gagaacagca agcagctgga gaccaagacc cccggccaga tccagctgga gcgctaccag      480

acctacggcc agctgcgcgg cgacttcacc gtggagaagg acggcaagaa gcaccgcctg      540

atcaacgtgt tccccaccag cgcctaccgc agcgaggccc tgcgcatcct gcagacccag      600

caggagttca acccccagat caccgacgag ttcatcaacc gctacctgga gatcctgacc      660

ggcaagcgca agtactacca cggccccggc aacgagaaga gccgcaccga ctacggccgc      720

taccgcacca gcggcgagac cctggacaac atcttcggca tcctgatcgg caagtgcacc      780

ttctaccccg acgagttccg cgccgccaag gccagctaca ccgcccagga gttcaacctg      840

ctgaacgacc tgaacaacct gaccgtgccc accgagacca agaagctgag caaggagcag      900

aagaaccaga tcatcaacta cgtgaagaac gagaaggcca tgggccccgc caagctgttc      960

aagtacatcg ccaagctgct gagctgcgac gtggccgaca tcaagggcta ccgcatcgac     1020

aagagcggca aggccgagat ccacaccttc gaggcctacc gcaagatgaa gaccctggag     1080

accctggaca tcgagcagat ggaccgcgag accctggaca agctggccta cgtgctgacc     1140

ctgaacaccg agcgcgaggg catccaggag gccctggagc acgagttcgc cgacggcagc     1200

ttcagccaga agcaggtgga cgagctggtg cagttccgca aggccaacag cagcatcttc     1260

ggcaagggct ggcacaactt cagcgtgaag ctgatgatgg agctgatccc cgagctgtac     1320

gagaccagcg aggagcagat gaccatcctg acccgcctgg gcaagcagaa gaccaccagc     1380

agcagcaaca agaccaagta catcgacgag aagctgctga ccgaggagat ctacaacccc     1440

gtggtggcca agagcgtgcg ccaggccatc aagatcgtga acgccgccat caaggagtac     1500

ggcgacttcg acaacatcgt gatcgagatg gcccgcgaga ccaacgagga cgacgagaag     1560

aaggccatcc agaagatcca gaaggccaac aaggacgaga aggacgccgc catgctgaag     1620

gccgccaacc agtacaacgg caaggccgag ctgccccaca gcgtgttcca cggccacaag     1680

cagctggcca ccaagatccg cctgtggcac cagcagggcg agcgctgcct gtacaccggc     1740

aagaccatca gcatccacga cctgatcaac aacagcaacc agttcgaggt ggaccacatc     1800

ctgcccctga gcatcacctt cgacgacagc ctggccaaca aggtgctggt gtacgccacc     1860

gccaaccagg agaagggcca gcgcaccccc taccaggccc tggacagcat ggacgacgcc     1920

tggagcttcc gcgagctgaa ggccttcgtg cgcgagagca agaccctgag caacaagaag     1980

aaggagtacc tgctgaccga ggaggacatc agcaagttcg acgtgcgcaa gaagttcatc     2040

gagcgcaacc tggtggacac ccgctacgcc agccgcgtgg tgctgaacgc cctgcaggag     2100

cacttccgcg cccacaagat cgacaccaag gtgagcgtgg tgcgcggcca gttcaccagc     2160

cagctgcgcc gccactgggg catcgagaag acccgcgaca cctaccacca ccacgccgtg     2220

gacgccctga tcattgcggc ttctagccag ctgaacctgt ggaagaagca gaagaacacc     2280

ctggtgagct acagcgagga ccagctgctg gacatcgaga ccggcgagct gatcagcgac     2340

gacgagtaca aggagagcgt gttcaaggcc ccctaccagc acttcgtgga caccctgaag     2400

agcaaggagt tcgaggacag catcctgttc agctaccagg tggacagcaa gttcaaccgc     2460

aagatcagcg acgccaccat ctacgccacc cgccaggcca aggtgggcaa ggacaaggcc     2520

gacgagacct acgtgctggg caagatcaag gacatctaca cccaggacgg ctacgacgcc     2580

ttcatgaaga tctacaagaa ggacaagagc aagttcctga tgtaccgcca cgacccccag     2640

accttcgaga aggtgatcga gcccatcctg gagaactacc ccaacaagca gatcaacgat     2700

aaaggcaagg aggtgccctg caaccccttc ctgaagtaca aggaggagca cggctacatc     2760

cgcaagtaca gcaagaaggg caacggcccc gagatcaaga gcctgaagta ctacgacagc     2820

aagctgggca accacatcga catcaccccc aaggacagca acaacaaggt ggtgctgcag     2880

agcgtgagcc cctggcgcgc cgacgtgtac ttcaacaaga ccaccggcaa gtacgagatc     2940

ctgggcctga agtacgccga cctgcagttt gataagggca ccggcaccta caagatcagc     3000

caggagaagt acaacgacat caagaagaag gagggcgtgg acagcgacag cgagttcaag     3060

ttcaccctgt acaagaacga ccttctgctg gtgaaggaca ccgagaccaa ggagcaacag     3120

ctgttccgct tcctgagccg caccatgccc aagcagaagc actacgtgga gctgaagccc     3180

tacgacaagc agaagttcga gggcggcgag gccctgatca aggtgctggg caacgtggcc     3240

aacagcggcc agtgcaagaa gggcctgggc aagagcaaca tcagcatcta caaggtgcgc     3300

accgacgtgc tgggcaacca gcacatcatc aagaacgagg gcgacaagcc caagctggac     3360

ttcagcaggg ctgaccccaa gaagaagagg aaggtgtga                            3399


<210> 13
<211> 3459
<212> DNA
<213> Streptococcus thermophilus

<400> 13
atgagcgacc tggtgctggg cctggacatc ggcatcggca gcgtgggcgt gggcatcctg       60

aacaaggtga ccggcgagat catccacaag aacagtcgca tcttccctgc tgctcaggct      120

gagaacaacc tggtgcgccg caccaaccgc cagggtcgcc ggcttgctcg ccgcaagaag      180

caccggcgcg tgcgcctgaa ccgcctgttc gaggagagcg gcctgatcac cgacttcacc      240

aagatcagca tcaacctgaa cccctaccag ctgcgcgtga agggcctgac cgacgagctg      300

agcaacgagg agctgttcat cgccctgaag aacatggtga agcaccgcgg catcagctac      360

ctggacgacg ccagcgacga cggcaacagc agcgtgggcg actacgccca gatcgtgaag      420

gagaacagca agcagctgga gaccaagacc cccggccaga tccagctgga gcgctaccag      480

acctacggcc agctgcgcgg cgacttcacc gtggagaagg acggcaagaa gcaccgcctg      540

atcaacgtgt tccccaccag cgcctaccgc agcgaggccc tgcgcatcct gcagacccag      600

caggagttca acccccagat caccgacgag ttcatcaacc gctacctgga gatcctgacc      660

ggcaagcgca agtactacca cggccccggc aacgagaaga gccgcaccga ctacggccgc      720

taccgcacca gcggcgagac cctggacaac atcttcggca tcctgatcgg caagtgcacc      780

ttctaccccg acgagttccg cgccgccaag gccagctaca ccgcccagga gttcaacctg      840

ctgaacgacc tgaacaacct gaccgtgccc accgagacca agaagctgag caaggagcag      900

aagaaccaga tcatcaacta cgtgaagaac gagaaggcca tgggccccgc caagctgttc      960

aagtacatcg ccaagctgct gagctgcgac gtggccgaca tcaagggcta ccgcatcgac     1020

aagagcggca aggccgagat ccacaccttc gaggcctacc gcaagatgaa gaccctggag     1080

accctggaca tcgagcagat ggaccgcgag accctggaca agctggccta cgtgctgacc     1140

ctgaacaccg agcgcgaggg catccaggag gccctggagc acgagttcgc cgacggcagc     1200

ttcagccaga agcaggtgga cgagctggtg cagttccgca aggccaacag cagcatcttc     1260

ggcaagggct ggcacaactt cagcgtgaag ctgatgatgg agctgatccc cgagctgtac     1320

gagaccagcg aggagcagat gaccatcctg acccgcctgg gcaagcagaa gaccaccagc     1380

agcagcaaca agaccaagta catcgacgag aagctgctga ccgaggagat ctacaacccc     1440

gtggtggcca agagcgtgcg ccaggccatc aagatcgtga acgccgccat caaggagtac     1500

ggcgacttcg acaacatcgt gatcgagatg gcccgcgaga ccaacgagga cgacgagaag     1560

aaggccatcc agaagatcca gaaggccaac aaggacgaga aggacgccgc catgctgaag     1620

gccgccaacc agtacaacgg caaggccgag ctgccccaca gcgtgttcca cggccacaag     1680

cagctggcca ccaagatccg cctgtggcac cagcagggcg agcgctgcct gtacaccggc     1740

aagaccatca gcatccacga cctgatcaac aacagcaacc agttcgaggt ggaccacatc     1800

ctgcccctga gcatcacctt cgacgacagc ctggccaaca aggtgctggt gtacgccacc     1860

gccaaccagg agaagggcca gcgcaccccc taccaggccc tggacagcat ggacgacgcc     1920

tggagcttcc gcgagctgaa ggccttcgtg cgcgagagca agaccctgag caacaagaag     1980

aaggagtacc tgctgaccga ggaggacatc agcaagttcg acgtgcgcaa gaagttcatc     2040

gagcgcaacc tggtggacac ccgctacgcc agccgcgtgg tgctgaacgc cctgcaggag     2100

cacttccgcg cccacaagat cgacaccaag gtgagcgtgg tgcgcggcca gttcaccagc     2160

cagctgcgcc gccactgggg catcgagaag acccgcgaca cctaccacca ccacgccgtg     2220

gacgccctga tcattgcggc ttctagccag ctgaacctgt ggaagaagca gaagaacacc     2280

ctggtgagct acagcgagga ccagctgctg gacatcgaga ccggcgagct gatcagcgac     2340

gacgagtaca aggagagcgt gttcaaggcc ccctaccagc acttcgtgga caccctgaag     2400

agcaaggagt tcgaggacag catcctgttc agctaccagg tggacagcaa gttcaaccgc     2460

aagatcagcg acgccaccat ctacgccacc cgccaggcca aggtgggcaa ggacaaggcc     2520

gacgagacct acgtgctggg caagatcaag gacatctaca cccaggacgg ctacgacgcc     2580

ttcatgaaga tctacaagaa ggacaagagc aagttcctga tgtaccgcca cgacccccag     2640

accttcgaga aggtgatcga gcccatcctg gagaactacc ccaacaagca gatcaacgat     2700

aaaggcaagg aggtgccctg caaccccttc ctgaagtaca aggaggagca cggctacatc     2760

cgcaagtaca gcaagaaggg caacggcccc gagatcaaga gcctgaagta ctacgacagc     2820

aagctgggca accacatcga catcaccccc aaggacagca acaacaaggt ggtgctgcag     2880

agcgtgagcc cctggcgcgc cgacgtgtac ttcaacaaga ccaccggcaa gtacgagatc     2940

ctgggcctga agtacgccga cctgcagttt gataagggca ccggcaccta caagatcagc     3000

caggagaagt acaacgacat caagaagaag gagggcgtgg acagcgacag cgagttcaag     3060

ttcaccctgt acaagaacga ccttctgctg gtgaaggaca ccgagaccaa ggagcaacag     3120

ctgttccgct tcctgagccg caccatgccc aagcagaagc actacgtgga gctgaagccc     3180

tacgacaagc agaagttcga gggcggcgag gccctgatca aggtgctggg caacgtggcc     3240

aacagcggcc agtgcaagaa gggcctgggc aagagcaaca tcagcatcta caaggtgcgc     3300

accgacgtgc tgggcaacca gcacatcatc aagaacgagg gcgacaagcc caagctggac     3360

ttcgcggccg cagatccaaa aaagaagaga aaggtagatc caaaaaagaa gagaaaggta     3420

gatccaaaaa agaagagaaa ggtagatacg gccgcatag                            3459


<210> 14
<211> 3585
<212> DNA
<213> Streptococcus thermophilus

<400> 14
atgagcgacc tggtgctggg cctggccatc ggcatcggca gcgtgggcgt gggcatcctg       60

aacaaggtga ccggcgagat catccacaag aacagtcgca tcttccctgc tgctcaggct      120

gagaacaacc tggtgcgccg caccaaccgc cagggtcgcc ggcttgctcg ccgcaagaag      180

caccggcgcg tgcgcctgaa ccgcctgttc gaggagagcg gcctgatcac cgacttcacc      240

aagatcagca tcaacctgaa cccctaccag ctgcgcgtga agggcctgac cgacgagctg      300

agcaacgagg agctgttcat cgccctgaag aacatggtga agcaccgcgg catcagctac      360

ctggacgacg ccagcgacga cggcaacagc agcgtgggcg actacgccca gatcgtgaag      420

gagaacagca agcagctgga gaccaagacc cccggccaga tccagctgga gcgctaccag      480

acctacggcc agctgcgcgg cgacttcacc gtggagaagg acggcaagaa gcaccgcctg      540

atcaacgtgt tccccaccag cgcctaccgc agcgaggccc tgcgcatcct gcagacccag      600

caggagttca acccccagat caccgacgag ttcatcaacc gctacctgga gatcctgacc      660

ggcaagcgca agtactacca cggccccggc aacgagaaga gccgcaccga ctacggccgc      720

taccgcacca gcggcgagac cctggacaac atcttcggca tcctgatcgg caagtgcacc      780

ttctaccccg acgagttccg cgccgccaag gccagctaca ccgcccagga gttcaacctg      840

ctgaacgacc tgaacaacct gaccgtgccc accgagacca agaagctgag caaggagcag      900

aagaaccaga tcatcaacta cgtgaagaac gagaaggcca tgggccccgc caagctgttc      960

aagtacatcg ccaagctgct gagctgcgac gtggccgaca tcaagggcta ccgcatcgac     1020

aagagcggca aggccgagat ccacaccttc gaggcctacc gcaagatgaa gaccctggag     1080

accctggaca tcgagcagat ggaccgcgag accctggaca agctggccta cgtgctgacc     1140

ctgaacaccg agcgcgaggg catccaggag gccctggagc acgagttcgc cgacggcagc     1200

ttcagccaga agcaggtgga cgagctggtg cagttccgca aggccaacag cagcatcttc     1260

ggcaagggct ggcacaactt cagcgtgaag ctgatgatgg agctgatccc cgagctgtac     1320

gagaccagcg aggagcagat gaccatcctg acccgcctgg gcaagcagaa gaccaccagc     1380

agcagcaaca agaccaagta catcgacgag aagctgctga ccgaggagat ctacaacccc     1440

gtggtggcca agagcgtgcg ccaggccatc aagatcgtga acgccgccat caaggagtac     1500

ggcgacttcg acaacatcgt gatcgagatg gcccgcgaga ccaacgagga cgacgagaag     1560

aaggccatcc agaagatcca gaaggccaac aaggacgaga aggacgccgc catgctgaag     1620

gccgccaacc agtacaacgg caaggccgag ctgccccaca gcgtgttcca cggccacaag     1680

cagctggcca ccaagatccg cctgtggcac cagcagggcg agcgctgcct gtacaccggc     1740

aagaccatca gcatccacga cctgatcaac aacagcaacc agttcgaggt ggctgccatc     1800

ctgcccctga gcatcacctt cgacgacagc ctggccaaca aggtgctggt gtacgccacc     1860

gccgctcagg agaagggcca gcgcaccccc taccaggccc tggacagcat ggacgacgcc     1920

tggagcttcc gcgagctgaa ggccttcgtg cgcgagagca agaccctgag caacaagaag     1980

aaggagtacc tgctgaccga ggaggacatc agcaagttcg acgtgcgcaa gaagttcatc     2040

gagcgcaacc tggtggacac ccgctacgcc agccgcgtgg tgctgaacgc cctgcaggag     2100

cacttccgcg cccacaagat cgacaccaag gtgagcgtgg tgcgcggcca gttcaccagc     2160

cagctgcgcc gccactgggg catcgagaag acccgcgaca cctaccacca ccacgccgtg     2220

gacgccctga tcattgcggc ttctagccag ctgaacctgt ggaagaagca gaagaacacc     2280

ctggtgagct acagcgagga ccagctgctg gacatcgaga ccggcgagct gatcagcgac     2340

gacgagtaca aggagagcgt gttcaaggcc ccctaccagc acttcgtgga caccctgaag     2400

agcaaggagt tcgaggacag catcctgttc agctaccagg tggacagcaa gttcaaccgc     2460

aagatcagcg acgccaccat ctacgccacc cgccaggcca aggtgggcaa ggacaaggcc     2520

gacgagacct acgtgctggg caagatcaag gacatctaca cccaggacgg ctacgacgcc     2580

ttcatgaaga tctacaagaa ggacaagagc aagttcctga tgtaccgcca cgacccccag     2640

accttcgaga aggtgatcga gcccatcctg gagaactacc ccaacaagca gatcaacgat     2700

aaaggcaagg aggtgccctg caaccccttc ctgaagtaca aggaggagca cggctacatc     2760

cgcaagtaca gcaagaaggg caacggcccc gagatcaaga gcctgaagta ctacgacagc     2820

aagctgggca accacatcga catcaccccc aaggacagca acaacaaggt ggtgctgcag     2880

agcgtgagcc cctggcgcgc cgacgtgtac ttcaacaaga ccaccggcaa gtacgagatc     2940

ctgggcctga agtacgccga cctgcagttt gataagggca ccggcaccta caagatcagc     3000

caggagaagt acaacgacat caagaagaag gagggcgtgg acagcgacag cgagttcaag     3060

ttcaccctgt acaagaacga ccttctgctg gtgaaggaca ccgagaccaa ggagcaacag     3120

ctgttccgct tcctgagccg caccatgccc aagcagaagc actacgtgga gctgaagccc     3180

tacgacaagc agaagttcga gggcggcgag gccctgatca aggtgctggg caacgtggcc     3240

aacagcggcc agtgcaagaa gggcctgggc aagagcaaca tcagcatcta caaggtgcgc     3300

accgacgtgc tgggcaacca gcacatcatc aagaacgagg gcgacaagcc caagctggac     3360

ttcagcaggg ctgaccccaa gaagaagagg aaggtggagg ccagcggttc cggacgggct     3420

gacgcattgg acgattttga tctggatatg ctgggaagtg acgccctcga tgattttgac     3480

cttgacatgc ttggttcgga tgcccttgat gactttgacc tcgacatgct cggcagtgac     3540

gcccttgatg atttcgacct ggacatgctg attaactcta gatga                     3585


<210> 15
<211> 3606
<212> DNA
<213> Streptococcus thermophilus

<400> 15
atgcccaaga agaagaggaa ggtgagcgac ctggtgctgg gcctggccat cggcatcggc       60

agcgtgggcg tgggcatcct gaacaaggtg accggcgaga tcatccacaa gaacagtcgc      120

atcttccctg ctgctcaggc tgagaacaac ctggtgcgcc gcaccaaccg ccagggtcgc      180

cggcttgctc gccgcaagaa gcaccggcgc gtgcgcctga accgcctgtt cgaggagagc      240

ggcctgatca ccgacttcac caagatcagc atcaacctga acccctacca gctgcgcgtg      300

aagggcctga ccgacgagct gagcaacgag gagctgttca tcgccctgaa gaacatggtg      360

aagcaccgcg gcatcagcta cctggacgac gccagcgacg acggcaacag cagcgtgggc      420

gactacgccc agatcgtgaa ggagaacagc aagcagctgg agaccaagac ccccggccag      480

atccagctgg agcgctacca gacctacggc cagctgcgcg gcgacttcac cgtggagaag      540

gacggcaaga agcaccgcct gatcaacgtg ttccccacca gcgcctaccg cagcgaggcc      600

ctgcgcatcc tgcagaccca gcaggagttc aacccccaga tcaccgacga gttcatcaac      660

cgctacctgg agatcctgac cggcaagcgc aagtactacc acggccccgg caacgagaag      720

agccgcaccg actacggccg ctaccgcacc agcggcgaga ccctggacaa catcttcggc      780

atcctgatcg gcaagtgcac cttctacccc gacgagttcc gcgccgccaa ggccagctac      840

accgcccagg agttcaacct gctgaacgac ctgaacaacc tgaccgtgcc caccgagacc      900

aagaagctga gcaaggagca gaagaaccag atcatcaact acgtgaagaa cgagaaggcc      960

atgggccccg ccaagctgtt caagtacatc gccaagctgc tgagctgcga cgtggccgac     1020

atcaagggct accgcatcga caagagcggc aaggccgaga tccacacctt cgaggcctac     1080

cgcaagatga agaccctgga gaccctggac atcgagcaga tggaccgcga gaccctggac     1140

aagctggcct acgtgctgac cctgaacacc gagcgcgagg gcatccagga ggccctggag     1200

cacgagttcg ccgacggcag cttcagccag aagcaggtgg acgagctggt gcagttccgc     1260

aaggccaaca gcagcatctt cggcaagggc tggcacaact tcagcgtgaa gctgatgatg     1320

gagctgatcc ccgagctgta cgagaccagc gaggagcaga tgaccatcct gacccgcctg     1380

ggcaagcaga agaccaccag cagcagcaac aagaccaagt acatcgacga gaagctgctg     1440

accgaggaga tctacaaccc cgtggtggcc aagagcgtgc gccaggccat caagatcgtg     1500

aacgccgcca tcaaggagta cggcgacttc gacaacatcg tgatcgagat ggcccgcgag     1560

accaacgagg acgacgagaa gaaggccatc cagaagatcc agaaggccaa caaggacgag     1620

aaggacgccg ccatgctgaa ggccgccaac cagtacaacg gcaaggccga gctgccccac     1680

agcgtgttcc acggccacaa gcagctggcc accaagatcc gcctgtggca ccagcagggc     1740

gagcgctgcc tgtacaccgg caagaccatc agcatccacg acctgatcaa caacagcaac     1800

cagttcgagg tggctgccat cctgcccctg agcatcacct tcgacgacag cctggccaac     1860

aaggtgctgg tgtacgccac cgccgctcag gagaagggcc agcgcacccc ctaccaggcc     1920

ctggacagca tggacgacgc ctggagcttc cgcgagctga aggccttcgt gcgcgagagc     1980

aagaccctga gcaacaagaa gaaggagtac ctgctgaccg aggaggacat cagcaagttc     2040

gacgtgcgca agaagttcat cgagcgcaac ctggtggaca cccgctacgc cagccgcgtg     2100

gtgctgaacg ccctgcagga gcacttccgc gcccacaaga tcgacaccaa ggtgagcgtg     2160

gtgcgcggcc agttcaccag ccagctgcgc cgccactggg gcatcgagaa gacccgcgac     2220

acctaccacc accacgccgt ggacgccctg atcattgcgg cttctagcca gctgaacctg     2280

tggaagaagc agaagaacac cctggtgagc tacagcgagg accagctgct ggacatcgag     2340

accggcgagc tgatcagcga cgacgagtac aaggagagcg tgttcaaggc cccctaccag     2400

cacttcgtgg acaccctgaa gagcaaggag ttcgaggaca gcatcctgtt cagctaccag     2460

gtggacagca agttcaaccg caagatcagc gacgccacca tctacgccac ccgccaggcc     2520

aaggtgggca aggacaaggc cgacgagacc tacgtgctgg gcaagatcaa ggacatctac     2580

acccaggacg gctacgacgc cttcatgaag atctacaaga aggacaagag caagttcctg     2640

atgtaccgcc acgaccccca gaccttcgag aaggtgatcg agcccatcct ggagaactac     2700

cccaacaagc agatcaacga taaaggcaag gaggtgccct gcaacccctt cctgaagtac     2760

aaggaggagc acggctacat ccgcaagtac agcaagaagg gcaacggccc cgagatcaag     2820

agcctgaagt actacgacag caagctgggc aaccacatcg acatcacccc caaggacagc     2880

aacaacaagg tggtgctgca gagcgtgagc ccctggcgcg ccgacgtgta cttcaacaag     2940

accaccggca agtacgagat cctgggcctg aagtacgccg acctgcagtt tgataagggc     3000

accggcacct acaagatcag ccaggagaag tacaacgaca tcaagaagaa ggagggcgtg     3060

gacagcgaca gcgagttcaa gttcaccctg tacaagaacg accttctgct ggtgaaggac     3120

accgagacca aggagcaaca gctgttccgc ttcctgagcc gcaccatgcc caagcagaag     3180

cactacgtgg agctgaagcc ctacgacaag cagaagttcg agggcggcga ggccctgatc     3240

aaggtgctgg gcaacgtggc caacagcggc cagtgcaaga agggcctggg caagagcaac     3300

atcagcatct acaaggtgcg caccgacgtg ctgggcaacc agcacatcat caagaacgag     3360

ggcgacaagc ccaagctgga cttcagcagg gctgacccca agaagaagag gaaggtggag     3420

gccagcggtt ccggacgggc tgacgcattg gacgattttg atctggatat gctgggaagt     3480

gacgccctcg atgattttga ccttgacatg cttggttcgg atgcccttga tgactttgac     3540

ctcgacatgc tcggcagtga cgcccttgat gatttcgacc tggacatgct gattaactct     3600

agatga                                                                3606


<210> 16
<211> 3366
<212> DNA
<213> Streptococcus thermophilus

<400> 16
atgagtgact tagttttagg acttgatatc ggtataggtt ctgttggtgt aggtatcctt       60

aacaaagtga caggagaaat tatccataaa aactcacgca tcttcccagc agctcaagcg      120

gaaaataacc tagtacgtag aacgaatcgt caaggaagac gcttgacacg acgtaaaaaa      180

catcgtagag ttcgtttaaa tcgtctattt gaggaaagtg gattaatcac cgattttacg      240

aagatttcaa ttaatcttaa cccatatcaa ttacgagtta agggcttgac cgatgaattg      300

tctaatgaag aactgtttat cgctcttaaa aatatggtga aacaccgtgg gattagttac      360

ctcgatgatg ctagtgatga cggaaattca tcaataggag actatgcaca aattgttaag      420

gaaaatagta aacaattaga aactaagaca ccgggacaga tacagttgga acgctaccaa      480

acatatggtc aattacgtgg tgattttact gttgagaaag atggcaaaaa acatcgcttg      540

attaatgtct ttccaacatc agcttatcgt tcagaagcct taaggatact gcaaactcaa      600

caagaattta atccacagat tacagatgaa tttattaatc gttatctcga aattttaact      660

ggaaaacgga aatattatca tggacccgga aatgaaaagt cacggactga ttatggtcgt      720

tacagaacga gtggagaaac tttagacaat atttttggaa ttctaattgg gaaatgtaca      780

ttttatccag acgagtttag agcagcaaaa gcttcctaca cggctcaaga attcaatttg      840

ctaaatgatt tgaacaatct aacagttcct actgaaacca aaaagttgag caaagaacag      900

aagaatcaaa tcattaatta tgtcaaaaat gaaaaggcaa tggggccagc gaaacttttt      960

aaatatatcg ctaagttact ttcttgtgat gttgcagata tcaagggata ccgtatcgac     1020

aaatcaggta aggctgagat tcatactttc gaagcctatc gaaaaatgaa aacgcttgaa     1080

accttagata ttgagcaaat ggatagagaa acgcttgata aattagccta tgtcttaaca     1140

ttaaacactg agagggaagg tattcaagaa gccttagaac atgaatttgc tgatggtagc     1200

tttagccaga agcaagttga cgaattggtt caattccgca aagcaaatag ttccattttt     1260

ggaaaaggat ggcataattt ttctgtcaaa ctgatgatgg agttaattcc agaattgtat     1320

gagacgtcag aagagcaaat gactatccta acacgacttg gaaaacaaaa aacgacttcg     1380

tcttcaaata aaacaaaata tatagatgaa aaactattaa ctgaagaaat ctataatcct     1440

gttgttgcta agtctgttcg ccaggctata aaaatcgtaa atgcggcgat taaagaatac     1500

ggagactttg acaatattgt catcgaaatg gctcgtgaaa caaatgaaga tgatgaaaag     1560

aaagctattc aaaagattca aaaagccaac aaagatgaaa aagatgcagc aatgcttaag     1620

gctgctaacc aatataatgg aaaggctgaa ttaccacata gtgttttcca cggtcataag     1680

caattagcga ctaaaatccg cctttggcat cagcaaggag aacgttgcct ttatactggt     1740

aagacaatct caatccatga tttgataaat aattctaatc agtttgaagt agatcatatt     1800

ttacctcttt ctatcacatt cgatgatagc cttgcaaata aggttttggt ttatgcaact     1860

gctaaccaag aaaaaggaca acgaacacct tatcaggctt tagatagtat ggatgatgcg     1920

tggtctttcc gtgaattaaa agcttttgta cgtgagtcaa aaacactttc gaacaagaaa     1980

aaagaatacc tccttacaga agaagatatt tcaaagtttg atgttcgaaa gaaatttatt     2040

gaacgaaatc ttgtagatac aagatacgct tcaagagttg tcctcaatgc ccttcaagaa     2100

cactttagag ctcacaagat tgatacaaaa gtttccgtgg ttcgtggcca atttacatct     2160

caattgagac gccattgggg aattgagaag actcgtgata cttatcatca ccatgctgtc     2220

gatgcattga ttattgccgc ctcaagtcag ttgaatttgt ggaaaaaaca aaagaatacc     2280

cttgtaagtt attcagaaga ccaactcctt gatattgaaa caggtgaact tattagtgat     2340

gatgagtaca aggaatctgt gttcaaagcc ccttatcaac attttgttga tacattgaag     2400

agtaaagaat ttgaagacag tatcttattc tcttatcaag tggattctaa gtttaatcgt     2460

aaaatatcag atgccactat ttatgcgaca agacaggcta aagtaggaaa agataaggcg     2520

gatgaaactt atgtcttagg gaaaatcaaa gatatttata ctcaggatgg ttatgatgcc     2580

tttatgaaga tttataagaa ggataagtca aaattcctca tgtatcgtca cgacccacaa     2640

acctttgaga aagttatcga gccaatttta gagaactatc ctaataagca aataaatgaa     2700

aaagggaaag aggtaccatg taatcctttc ctaaaatata aagaagaaca tggctatatt     2760

cgtaaatata gtaaaaaagg caatggtcct gaaatcaaga gtcttaaata ctatgatagt     2820

aagctaggca atcatattga tattactccg aaggatagta acaataaagt tgtcttacag     2880

tcagtttctc catggagagc ggatgtctat ttcaataaga ctactggaaa atacgaaatc     2940

ctcggattga aatatgctga tttacaattt gaaaaaggga caggaacata taagatttcc     3000

caggaaaaat acaatgacat taagaaaaaa gagggtgtag attctgattc agaattcaag     3060

tttacacttt ataaaaatga tttgttactc gttaaagata cagaaacaaa agaacaacag     3120

cttttccgtt ttctttctcg aactatgcct aaacaaaagc attatgttga attaaaacct     3180

tatgataaac agaaatttga aggaggtgag gcgttaatta aagtgttggg taacgttgct     3240

aatagtggtc aatgcaaaaa agggctagga aaatcaaata tttctattta taaggtaaga     3300

acagatgtcc taggaaatca gcatatcatc aaaaatgagg gtgataagcc taagctagat     3360

ttttaa                                                                3366


<210> 17
<211> 4167
<212> DNA
<213> Streptococcus thermophilus

<400> 17
atgactaagc catactcaat tggacttgat attggaacga atagtgttgg atgggctgta       60

ataactgata attacaaggt tccgtctaaa aaaatgaaag tcttaggaaa tacgagtaaa      120

aagtatatca aaaagaacct gttaggtgta ttactctttg actctggaat cacagcagaa      180

ggaagaagat tgaagcgtac tgcaagaaga cgttatacta gacgccgtaa tcgtatcctt      240

tatttgcagg aaatttttag cacggagatg gctacattag atgatgcttt ctttcaaaga      300

cttgacgatt cgtttttagt tcctgatgat aaacgtgata gtaagtatcc gatatttgga      360

aacttagtag aagaaaaagt ctatcatgat gaatttccaa ctatctatca tttaaggaaa      420

tatttagcag atagtactaa aaaagcagat ttgcgtctag tttatcttgc attggctcat      480

atgattaaat atagaggtca cttcttaatt gaaggagagt ttaattcaaa aaataatgat      540

attcagaaga attttcaaga ctttttggac acttataatg ctatttttga atcggattta      600

tcacttgaga atagtaaaca acttgaggaa attgttaaag ataagattag taaattagaa      660

aagaaagatc gtattttaaa actcttccct ggggagaaga attcggggat tttttcagag      720

tttctaaagt tgattgtagg aaatcaagct gattttagga aatgttttaa tttagacgaa      780

aaagcctcct tacatttttc caaagaaagc tatgatgaag atttagagac tttgttaggt      840

tatattggag atgattacag tgatgtcttt ctcaaagcaa agaaacttta tgatgctatt      900

cttttatcgg gttttctgac tgtaactgat aatgagacag aagcacctct ctcttctgct      960

atgataaagc gatataatga acacaaagaa gatttagcgt tactaaagga atatataaga     1020

aatatttcac taaaaacgta taatgaagta tttaaagatg acaccaaaaa tggttatgct     1080

ggttatattg atggaaaaac aaatcaggaa gatttctacg tatatctaaa aaacctattg     1140

gctgaatttg aaggtgcgga ttattttctt gaaaaaattg atcgagaaga ttttttgaga     1200

aagcaacgta catttgacaa tggttcgata ccatatcaga ttcatcttca agaaatgaga     1260

gcaattcttg ataagcaagc taaattttat cctttcttgg ctaaaaataa agaaagaatc     1320

gagaagattt taaccttccg aattccttat tatgtaggtc cacttgcgag agggaatagt     1380

gattttgcct ggtcaataag aaaacgaaat gaaaaaatta caccttggaa ttttgaggac     1440

gttattgaca aagaatcttc ggcagaggct ttcattaatc gaatgactag ttttgatttg     1500

tatttgccag aagagaaggt acttccaaag catagtctct tatacgaaac ttttaatgta     1560

tataatgaat taacaaaagt tagatttatt gccgaaagta tgagagatta tcaattttta     1620

gatagtaagc agaagaaaga tattgttaga ctttatttta aagataaaag gaaagttact     1680

gataaggata ttattgaata tttacatgca atttatgggt atgatggaat tgaattaaaa     1740

ggcatagaga aacagtttaa ttctagttta tctacttatc acgatctttt aaatattatt     1800

aatgataaag agtttttgga tgatagttca aatgaagcga ttatcgaaga aattatccat     1860

actttgacaa tttttgaaga tagagagatg ataaaacaac gtctttcaaa atttgagaat     1920

atattcgata aatccgtttt gaaaaagtta tctcgtagac attacactgg ctggggtaag     1980

ttatctgcta agcttattaa tggtattcga gatgaaaaat ctggtaatac tattcttgat     2040

tacttaattg atgatggtat ttctaaccgt aatttcatgc aacttattca cgatgatgct     2100

ctttctttta aaaagaagat acagaaagca caaattattg gtgacgaaga taaaggtaat     2160

attaaagagg tcgttaagtc tttgccaggt agtcctgcga ttaaaaaagg tattttacaa     2220

agcataaaaa ttgtagatga attggtcaaa gtaatgggag gaagaaaacc cgagtcaatt     2280

gttgttgaga tggctcgtga aaatcaatat accaatcaag gtaagtctaa ttcccaacaa     2340

cgcttgaaac gtttagaaaa atctctcaaa gagttaggta gtaagatact taaggaaaat     2400

attcctgcaa aactttctaa aatagacaat aacgcacttc aaaatgatcg actttactta     2460

tactatcttc aaaatggaaa agatatgtat accggagatg atttagatat tgatagatta     2520

agtaattatg atattgatca tattattcct caagcttttt tgaaagataa ttctattgac     2580

aataaagtac ttgtttcatc tgctagtaac cgtggtaaat cagatgattt tccaagttta     2640

gaggttgtca aaaaaagaaa gacattttgg tatcaattat tgaaatcaaa attaatttct     2700

caacgaaaat ttgataatct gacaaaagct gaacggggag gattgttacc tgaggacaaa     2760

gctggtttta ttcaacgcca gttggttgaa acacgtcaaa taacaaaaca tgtagctcgt     2820

ttacttgatg agaaatttaa taataaaaaa gatgaaaata atagagcggt acgaacagta     2880

aaaattatta ccttgaaatc taccttagtt tctcaatttc gtaaggattt tgaactttat     2940

aaagttcgtg aaatcaatga ttttcatcat gctcatgatg cttacttgaa tgccgttata     3000

gcaagtgctt tacttaagaa ataccctaaa ctagagccag aatttgtgta cggtgattat     3060

ccaaaataca atagttttag agaaagaaag tccgctacag aaaaggtata tttctattca     3120

aatatcatga atatctttaa aaaatctatt tctttagctg atggtagagt tattgaaaga     3180

ccacttattg aggtaaatga ggagaccggc gaatccgttt ggaataaaga atctgattta     3240

gcaactgtaa ggagagtact ctcttatccg caagtaaatg ttgtgaaaaa agttgaggaa     3300

cagaatcacg gattggatag aggaaaacca aagggattgt ttaatgcaaa tctttcctca     3360

aagccaaaac caaatagtaa tgaaaattta gtaggtgcta aagagtatct tgaccccaaa     3420

aagtatgggg ggtatgctgg aatttctaat tcttttgctg ttcttgttaa agggacaatt     3480

gaaaaaggtg ctaagaaaaa aataacaaat gtactagaat ttcaaggtat ttctatttta     3540

gataggatta attatagaaa agataaactt aattttttac ttgaaaaagg ttataaagat     3600

attgagttaa ttattgaact acctaaatat agtttatttg aactttcaga tggttcacgt     3660

cgtatgttgg ctagtatttt gtcaacgaat aataagaggg gagagattca caaaggaaat     3720

cagatttttc tttcacagaa gtttgtgaaa ttactttatc atgctaagag aataagtaac     3780

acaattaatg agaatcatag aaaatatgtt gagaaccata aaaaagagtt tgaagaatta     3840

ttttactaca ttcttgagtt taatgagaat tatgttggag ctaaaaagaa tggtaaactt     3900

ttaaactctg cctttcaatc ttggcaaaat catagtatag atgaactctg tagtagtttt     3960

ataggaccta ccggaagtga aagaaagggg ctatttgaat taacctctcg tggaagtgct     4020

gctgattttg aatttttagg tgttaaaatt ccaaggtata gagactatac cccatcatcc     4080

ctattaaaag atgccacact tattcatcaa tctgttacag gcctctatga aacacgaata     4140

gaccttgcca aactaggaga gggttaa                                         4167


<210> 18
<211> 3249
<212> DNA
<213> Neisseria meningitidis

<400> 18
atggccgcct tcaagcccaa ccccatcaac tacatcctgg gcctggacat cggcatcgcc       60

agcgtgggct gggccatggt ggagatcgac gaggacgaga accccatctg cctgatcgac      120

ctgggtgtgc gcgtgttcga gcgcgctgag gtgcccaaga ctggtgacag tctggctatg      180

gctcgccggc ttgctcgctc tgttcggcgc cttactcgcc ggcgcgctca ccgccttctg      240

cgcgctcgcc gcctgctgaa gcgcgagggt gtgctgcagg ctgccgactt cgacgagaac      300

ggcctgatca agagcctgcc caacactcct tggcagctgc gcgctgccgc tctggaccgc      360

aagctgactc ctctggagtg gagcgccgtg ctgctgcacc tgatcaagca ccgcggctac      420

ctgagccagc gcaagaacga gggcgagacc gccgacaagg agctgggtgc tctgctgaag      480

ggcgtggccg acaacgccca cgccctgcag actggtgact tccgcactcc tgctgagctg      540

gccctgaaca agttcgagaa ggagagcggc cacatccgca accagcgcgg cgactacagc      600

cacaccttca gccgcaagga cctgcaggcc gagctgatcc tgctgttcga gaagcagaag      660

gagttcggca acccccacgt gagcggcggc ctgaaggagg gcatcgagac cctgctgatg      720

acccagcgcc ccgccctgag cggcgacgcc gtgcagaaga tgctgggcca ctgcaccttc      780

gagccagccg agcccaaggc cgccaagaac acctacaccg ccgagcgctt catctggctg      840

accaagctga acaacctgcg catcctggag cagggcagcg agcgccccct gaccgacacc      900

gagcgcgcca ccctgatgga cgagccctac cgcaagagca agctgaccta cgcccaggcc      960

cgcaagctgc tgggtctgga ggacaccgcc ttcttcaagg gcctgcgcta cggcaaggac     1020

aacgccgagg ccagcaccct gatggagatg aaggcctacc acgccatcag ccgcgccctg     1080

gagaaggagg gcctgaagga caagaagagt cctctgaacc tgagccccga gctgcaggac     1140

gagatcggca ccgccttcag cctgttcaag accgacgagg acatcaccgg ccgcctgaag     1200

gaccgcatcc agcccgagat cctggaggcc ctgctgaagc acatcagctt cgacaagttc     1260

gtgcagatca gcctgaaggc cctgcgccgc atcgtgcccc tgatggagca gggcaagcgc     1320

tacgacgagg cctgcgccga gatctacggc gaccactacg gcaagaagaa caccgaggag     1380

aagatctacc tgcctcctat ccccgccgac gagatccgca accccgtggt gctgcgcgcc     1440

ctgagccagg cccgcaaggt gatcaacggc gtggtgcgcc gctacggcag ccccgcccgc     1500

atccacatcg agaccgcccg cgaggtgggc aagagcttca aggaccgcaa ggagatcgag     1560

aagcgccagg aggagaaccg caaggaccgc gagaaggccg ccgccaagtt ccgcgagtac     1620

ttccccaact tcgtgggcga gcccaagagc aaggacatcc tgaagctgcg cctgtacgag     1680

cagcagcacg gcaagtgcct gtacagcggc aaggagatca acctgggccg cctgaacgag     1740

aagggctacg tggagatcga ccacgccctg cccttcagcc gcacctggga cgacagcttc     1800

aacaacaagg tgctggtgct gggcagcgag aaccagaaca agggcaacca gaccccctac     1860

gagtacttca acggcaagga caacagccgc gagtggcagg agttcaaggc ccgcgtggag     1920

accagccgct tcccccgcag caagaagcag cgcatcctgc tgcagaagtt cgacgaggac     1980

ggcttcaagg agcgcaacct gaacgacacc cgctacgtga accgcttcct gtgccagttc     2040

gtggccgacc gcatgcgcct gaccggcaag ggcaagaagc gcgtgttcgc cagcaacggc     2100

cagatcacca acctgctgcg cggcttctgg ggcctgcgca aggtgcgcgc cgagaacgac     2160

cgccaccacg ccctggacgc cgtggtggtg gcctgcagca ccgtggccat gcagcagaag     2220

atcacccgct tcgtgcgcta caaggagatg aacgccttcg acggtaaaac catcgacaag     2280

gagaccggcg aggtgctgca ccagaagacc cacttccccc agccctggga gttcttcgcc     2340

caggaggtga tgatccgcgt gttcggcaag cccgacggca agcccgagtt cgaggaggcc     2400

gacacccccg agaagctgcg caccctgctg gccgagaagc tgagcagccg ccctgaggcc     2460

gtgcacgagt acgtgactcc tctgttcgtg agccgcgccc ccaaccgcaa gatgagcggt     2520

cagggtcaca tggagaccgt gaagagcgcc aagcgcctgg acgagggcgt gagcgtgctg     2580

cgcgtgcccc tgacccagct gaagctgaag gacctggaga agatggtgaa ccgcgagcgc     2640

gagcccaagc tgtacgaggc cctgaaggcc cgcctggagg cccacaagga cgaccccgcc     2700

aaggccttcg ccgagccctt ctacaagtac gacaaggccg gcaaccgcac ccagcaggtg     2760

aaggccgtgc gcgtggagca ggtgcagaag accggcgtgt gggtgcgcaa ccacaacggc     2820

atcgccgaca acgccaccat ggtgcgcgtg gacgtgttcg agaagggcga caagtactac     2880

ctggtgccca tctacagctg gcaggtggcc aagggcatcc tgcccgaccg cgccgtggtg     2940

cagggcaagg acgaggagga ctggcagctg atcgacgaca gcttcaactt caagttcagc     3000

ctgcacccca acgacctggt ggaggtgatc accaagaagg cccgcatgtt cggctacttc     3060

gccagctgcc accgcggcac cggcaacatc aacatccgca tccacgacct ggaccacaag     3120

atcggcaaga acggcatcct ggagggcatc ggcgtgaaga ccgccctgag cttccagaag     3180

taccagatcg acgagctggg caaggagatc cgcccctgcc gcctgaagaa gcgccctcct     3240

gtgcgctaa                                                             3249


<210> 19
<211> 3249
<212> DNA
<213> Neisseria meningitidis

<400> 19
atggccgcct tcaagcccaa ccccatcaac tacatcctgg gcctggccat cggcatcgcc       60

agcgtgggct gggccatggt ggagatcgac gaggacgaga accccatctg cctgatcgac      120

ctgggtgtgc gcgtgttcga gcgcgctgag gtgcccaaga ctggtgacag tctggctatg      180

gctcgccggc ttgctcgctc tgttcggcgc cttactcgcc ggcgcgctca ccgccttctg      240

cgcgctcgcc gcctgctgaa gcgcgagggt gtgctgcagg ctgccgactt cgacgagaac      300

ggcctgatca agagcctgcc caacactcct tggcagctgc gcgctgccgc tctggaccgc      360

aagctgactc ctctggagtg gagcgccgtg ctgctgcacc tgatcaagca ccgcggctac      420

ctgagccagc gcaagaacga gggcgagacc gccgacaagg agctgggtgc tctgctgaag      480

ggcgtggccg acaacgccca cgccctgcag actggtgact tccgcactcc tgctgagctg      540

gccctgaaca agttcgagaa ggagagcggc cacatccgca accagcgcgg cgactacagc      600

cacaccttca gccgcaagga cctgcaggcc gagctgatcc tgctgttcga gaagcagaag      660

gagttcggca acccccacgt gagcggcggc ctgaaggagg gcatcgagac cctgctgatg      720

acccagcgcc ccgccctgag cggcgacgcc gtgcagaaga tgctgggcca ctgcaccttc      780

gagccagccg agcccaaggc cgccaagaac acctacaccg ccgagcgctt catctggctg      840

accaagctga acaacctgcg catcctggag cagggcagcg agcgccccct gaccgacacc      900

gagcgcgcca ccctgatgga cgagccctac cgcaagagca agctgaccta cgcccaggcc      960

cgcaagctgc tgggtctgga ggacaccgcc ttcttcaagg gcctgcgcta cggcaaggac     1020

aacgccgagg ccagcaccct gatggagatg aaggcctacc acgccatcag ccgcgccctg     1080

gagaaggagg gcctgaagga caagaagagt cctctgaacc tgagccccga gctgcaggac     1140

gagatcggca ccgccttcag cctgttcaag accgacgagg acatcaccgg ccgcctgaag     1200

gaccgcatcc agcccgagat cctggaggcc ctgctgaagc acatcagctt cgacaagttc     1260

gtgcagatca gcctgaaggc cctgcgccgc atcgtgcccc tgatggagca gggcaagcgc     1320

tacgacgagg cctgcgccga gatctacggc gaccactacg gcaagaagaa caccgaggag     1380

aagatctacc tgcctcctat ccccgccgac gagatccgca accccgtggt gctgcgcgcc     1440

ctgagccagg cccgcaaggt gatcaacggc gtggtgcgcc gctacggcag ccccgcccgc     1500

atccacatcg agaccgcccg cgaggtgggc aagagcttca aggaccgcaa ggagatcgag     1560

aagcgccagg aggagaaccg caaggaccgc gagaaggccg ccgccaagtt ccgcgagtac     1620

ttccccaact tcgtgggcga gcccaagagc aaggacatcc tgaagctgcg cctgtacgag     1680

cagcagcacg gcaagtgcct gtacagcggc aaggagatca acctgggccg cctgaacgag     1740

aagggctacg tggagatcgc cgctgccctg cccttcagcc gcacctggga cgacagcttc     1800

aacaacaagg tgctggtgct gggcagcgag gctcagaaca agggcaacca gaccccctac     1860

gagtacttca acggcaagga caacagccgc gagtggcagg agttcaaggc ccgcgtggag     1920

accagccgct tcccccgcag caagaagcag cgcatcctgc tgcagaagtt cgacgaggac     1980

ggcttcaagg agcgcaacct gaacgacacc cgctacgtga accgcttcct gtgccagttc     2040

gtggccgacc gcatgcgcct gaccggcaag ggcaagaagc gcgtgttcgc cagcaacggc     2100

cagatcacca acctgctgcg cggcttctgg ggcctgcgca aggtgcgcgc cgagaacgac     2160

cgccaccacg ccctggacgc cgtggtggtg gcctgcagca ccgtggccat gcagcagaag     2220

atcacccgct tcgtgcgcta caaggagatg aacgccttcg acggtaaaac catcgacaag     2280

gagaccggcg aggtgctgca ccagaagacc cacttccccc agccctggga gttcttcgcc     2340

caggaggtga tgatccgcgt gttcggcaag cccgacggca agcccgagtt cgaggaggcc     2400

gacacccccg agaagctgcg caccctgctg gccgagaagc tgagcagccg ccctgaggcc     2460

gtgcacgagt acgtgactcc tctgttcgtg agccgcgccc ccaaccgcaa gatgagcggt     2520

cagggtcaca tggagaccgt gaagagcgcc aagcgcctgg acgagggcgt gagcgtgctg     2580

cgcgtgcccc tgacccagct gaagctgaag gacctggaga agatggtgaa ccgcgagcgc     2640

gagcccaagc tgtacgaggc cctgaaggcc cgcctggagg cccacaagga cgaccccgcc     2700

aaggccttcg ccgagccctt ctacaagtac gacaaggccg gcaaccgcac ccagcaggtg     2760

aaggccgtgc gcgtggagca ggtgcagaag accggcgtgt gggtgcgcaa ccacaacggc     2820

atcgccgaca acgccaccat ggtgcgcgtg gacgtgttcg agaagggcga caagtactac     2880

ctggtgccca tctacagctg gcaggtggcc aagggcatcc tgcccgaccg cgccgtggtg     2940

cagggcaagg acgaggagga ctggcagctg atcgacgaca gcttcaactt caagttcagc     3000

ctgcacccca acgacctggt ggaggtgatc accaagaagg cccgcatgtt cggctacttc     3060

gccagctgcc accgcggcac cggcaacatc aacatccgca tccacgacct ggaccacaag     3120

atcggcaaga acggcatcct ggagggcatc ggcgtgaaga ccgccctgag cttccagaag     3180

taccagatcg acgagctggg caaggagatc cgcccctgcc gcctgaagaa gcgccctcct     3240

gtgcgctaa                                                             3249


<210> 20
<211> 3282
<212> DNA
<213> Neisseria meningitidis

<400> 20
atggccgcct tcaagcccaa ccccatcaac tacatcctgg gcctggacat cggcatcgcc       60

agcgtgggct gggccatggt ggagatcgac gaggacgaga accccatctg cctgatcgac      120

ctgggtgtgc gcgtgttcga gcgcgctgag gtgcccaaga ctggtgacag tctggctatg      180

gctcgccggc ttgctcgctc tgttcggcgc cttactcgcc ggcgcgctca ccgccttctg      240

cgcgctcgcc gcctgctgaa gcgcgagggt gtgctgcagg ctgccgactt cgacgagaac      300

ggcctgatca agagcctgcc caacactcct tggcagctgc gcgctgccgc tctggaccgc      360

aagctgactc ctctggagtg gagcgccgtg ctgctgcacc tgatcaagca ccgcggctac      420

ctgagccagc gcaagaacga gggcgagacc gccgacaagg agctgggtgc tctgctgaag      480

ggcgtggccg acaacgccca cgccctgcag actggtgact tccgcactcc tgctgagctg      540

gccctgaaca agttcgagaa ggagagcggc cacatccgca accagcgcgg cgactacagc      600

cacaccttca gccgcaagga cctgcaggcc gagctgatcc tgctgttcga gaagcagaag      660

gagttcggca acccccacgt gagcggcggc ctgaaggagg gcatcgagac cctgctgatg      720

acccagcgcc ccgccctgag cggcgacgcc gtgcagaaga tgctgggcca ctgcaccttc      780

gagccagccg agcccaaggc cgccaagaac acctacaccg ccgagcgctt catctggctg      840

accaagctga acaacctgcg catcctggag cagggcagcg agcgccccct gaccgacacc      900

gagcgcgcca ccctgatgga cgagccctac cgcaagagca agctgaccta cgcccaggcc      960

cgcaagctgc tgggtctgga ggacaccgcc ttcttcaagg gcctgcgcta cggcaaggac     1020

aacgccgagg ccagcaccct gatggagatg aaggcctacc acgccatcag ccgcgccctg     1080

gagaaggagg gcctgaagga caagaagagt cctctgaacc tgagccccga gctgcaggac     1140

gagatcggca ccgccttcag cctgttcaag accgacgagg acatcaccgg ccgcctgaag     1200

gaccgcatcc agcccgagat cctggaggcc ctgctgaagc acatcagctt cgacaagttc     1260

gtgcagatca gcctgaaggc cctgcgccgc atcgtgcccc tgatggagca gggcaagcgc     1320

tacgacgagg cctgcgccga gatctacggc gaccactacg gcaagaagaa caccgaggag     1380

aagatctacc tgcctcctat ccccgccgac gagatccgca accccgtggt gctgcgcgcc     1440

ctgagccagg cccgcaaggt gatcaacggc gtggtgcgcc gctacggcag ccccgcccgc     1500

atccacatcg agaccgcccg cgaggtgggc aagagcttca aggaccgcaa ggagatcgag     1560

aagcgccagg aggagaaccg caaggaccgc gagaaggccg ccgccaagtt ccgcgagtac     1620

ttccccaact tcgtgggcga gcccaagagc aaggacatcc tgaagctgcg cctgtacgag     1680

cagcagcacg gcaagtgcct gtacagcggc aaggagatca acctgggccg cctgaacgag     1740

aagggctacg tggagatcga ccacgccctg cccttcagcc gcacctggga cgacagcttc     1800

aacaacaagg tgctggtgct gggcagcgag aaccagaaca agggcaacca gaccccctac     1860

gagtacttca acggcaagga caacagccgc gagtggcagg agttcaaggc ccgcgtggag     1920

accagccgct tcccccgcag caagaagcag cgcatcctgc tgcagaagtt cgacgaggac     1980

ggcttcaagg agcgcaacct gaacgacacc cgctacgtga accgcttcct gtgccagttc     2040

gtggccgacc gcatgcgcct gaccggcaag ggcaagaagc gcgtgttcgc cagcaacggc     2100

cagatcacca acctgctgcg cggcttctgg ggcctgcgca aggtgcgcgc cgagaacgac     2160

cgccaccacg ccctggacgc cgtggtggtg gcctgcagca ccgtggccat gcagcagaag     2220

atcacccgct tcgtgcgcta caaggagatg aacgccttcg acggtaaaac catcgacaag     2280

gagaccggcg aggtgctgca ccagaagacc cacttccccc agccctggga gttcttcgcc     2340

caggaggtga tgatccgcgt gttcggcaag cccgacggca agcccgagtt cgaggaggcc     2400

gacacccccg agaagctgcg caccctgctg gccgagaagc tgagcagccg ccctgaggcc     2460

gtgcacgagt acgtgactcc tctgttcgtg agccgcgccc ccaaccgcaa gatgagcggt     2520

cagggtcaca tggagaccgt gaagagcgcc aagcgcctgg acgagggcgt gagcgtgctg     2580

cgcgtgcccc tgacccagct gaagctgaag gacctggaga agatggtgaa ccgcgagcgc     2640

gagcccaagc tgtacgaggc cctgaaggcc cgcctggagg cccacaagga cgaccccgcc     2700

aaggccttcg ccgagccctt ctacaagtac gacaaggccg gcaaccgcac ccagcaggtg     2760

aaggccgtgc gcgtggagca ggtgcagaag accggcgtgt gggtgcgcaa ccacaacggc     2820

atcgccgaca acgccaccat ggtgcgcgtg gacgtgttcg agaagggcga caagtactac     2880

ctggtgccca tctacagctg gcaggtggcc aagggcatcc tgcccgaccg cgccgtggtg     2940

cagggcaagg acgaggagga ctggcagctg atcgacgaca gcttcaactt caagttcagc     3000

ctgcacccca acgacctggt ggaggtgatc accaagaagg cccgcatgtt cggctacttc     3060

gccagctgcc accgcggcac cggcaacatc aacatccgca tccacgacct ggaccacaag     3120

atcggcaaga acggcatcct ggagggcatc ggcgtgaaga ccgccctgag cttccagaag     3180

taccagatcg acgagctggg caaggagatc cgcccctgcc gcctgaagaa gcgccctcct     3240

gtgcgcagca gggctgaccc caagaagaag aggaaggtgt ga                        3282


<210> 21
<211> 3342
<212> DNA
<213> Neisseria meningitidis

<400> 21
atggccgcct tcaagcccaa ccccatcaac tacatcctgg gcctggacat cggcatcgcc       60

agcgtgggct gggccatggt ggagatcgac gaggacgaga accccatctg cctgatcgac      120

ctgggtgtgc gcgtgttcga gcgcgctgag gtgcccaaga ctggtgacag tctggctatg      180

gctcgccggc ttgctcgctc tgttcggcgc cttactcgcc ggcgcgctca ccgccttctg      240

cgcgctcgcc gcctgctgaa gcgcgagggt gtgctgcagg ctgccgactt cgacgagaac      300

ggcctgatca agagcctgcc caacactcct tggcagctgc gcgctgccgc tctggaccgc      360

aagctgactc ctctggagtg gagcgccgtg ctgctgcacc tgatcaagca ccgcggctac      420

ctgagccagc gcaagaacga gggcgagacc gccgacaagg agctgggtgc tctgctgaag      480

ggcgtggccg acaacgccca cgccctgcag actggtgact tccgcactcc tgctgagctg      540

gccctgaaca agttcgagaa ggagagcggc cacatccgca accagcgcgg cgactacagc      600

cacaccttca gccgcaagga cctgcaggcc gagctgatcc tgctgttcga gaagcagaag      660

gagttcggca acccccacgt gagcggcggc ctgaaggagg gcatcgagac cctgctgatg      720

acccagcgcc ccgccctgag cggcgacgcc gtgcagaaga tgctgggcca ctgcaccttc      780

gagccagccg agcccaaggc cgccaagaac acctacaccg ccgagcgctt catctggctg      840

accaagctga acaacctgcg catcctggag cagggcagcg agcgccccct gaccgacacc      900

gagcgcgcca ccctgatgga cgagccctac cgcaagagca agctgaccta cgcccaggcc      960

cgcaagctgc tgggtctgga ggacaccgcc ttcttcaagg gcctgcgcta cggcaaggac     1020

aacgccgagg ccagcaccct gatggagatg aaggcctacc acgccatcag ccgcgccctg     1080

gagaaggagg gcctgaagga caagaagagt cctctgaacc tgagccccga gctgcaggac     1140

gagatcggca ccgccttcag cctgttcaag accgacgagg acatcaccgg ccgcctgaag     1200

gaccgcatcc agcccgagat cctggaggcc ctgctgaagc acatcagctt cgacaagttc     1260

gtgcagatca gcctgaaggc cctgcgccgc atcgtgcccc tgatggagca gggcaagcgc     1320

tacgacgagg cctgcgccga gatctacggc gaccactacg gcaagaagaa caccgaggag     1380

aagatctacc tgcctcctat ccccgccgac gagatccgca accccgtggt gctgcgcgcc     1440

ctgagccagg cccgcaaggt gatcaacggc gtggtgcgcc gctacggcag ccccgcccgc     1500

atccacatcg agaccgcccg cgaggtgggc aagagcttca aggaccgcaa ggagatcgag     1560

aagcgccagg aggagaaccg caaggaccgc gagaaggccg ccgccaagtt ccgcgagtac     1620

ttccccaact tcgtgggcga gcccaagagc aaggacatcc tgaagctgcg cctgtacgag     1680

cagcagcacg gcaagtgcct gtacagcggc aaggagatca acctgggccg cctgaacgag     1740

aagggctacg tggagatcga ccacgccctg cccttcagcc gcacctggga cgacagcttc     1800

aacaacaagg tgctggtgct gggcagcgag aaccagaaca agggcaacca gaccccctac     1860

gagtacttca acggcaagga caacagccgc gagtggcagg agttcaaggc ccgcgtggag     1920

accagccgct tcccccgcag caagaagcag cgcatcctgc tgcagaagtt cgacgaggac     1980

ggcttcaagg agcgcaacct gaacgacacc cgctacgtga accgcttcct gtgccagttc     2040

gtggccgacc gcatgcgcct gaccggcaag ggcaagaagc gcgtgttcgc cagcaacggc     2100

cagatcacca acctgctgcg cggcttctgg ggcctgcgca aggtgcgcgc cgagaacgac     2160

cgccaccacg ccctggacgc cgtggtggtg gcctgcagca ccgtggccat gcagcagaag     2220

atcacccgct tcgtgcgcta caaggagatg aacgccttcg acggtaaaac catcgacaag     2280

gagaccggcg aggtgctgca ccagaagacc cacttccccc agccctggga gttcttcgcc     2340

caggaggtga tgatccgcgt gttcggcaag cccgacggca agcccgagtt cgaggaggcc     2400

gacacccccg agaagctgcg caccctgctg gccgagaagc tgagcagccg ccctgaggcc     2460

gtgcacgagt acgtgactcc tctgttcgtg agccgcgccc ccaaccgcaa gatgagcggt     2520

cagggtcaca tggagaccgt gaagagcgcc aagcgcctgg acgagggcgt gagcgtgctg     2580

cgcgtgcccc tgacccagct gaagctgaag gacctggaga agatggtgaa ccgcgagcgc     2640

gagcccaagc tgtacgaggc cctgaaggcc cgcctggagg cccacaagga cgaccccgcc     2700

aaggccttcg ccgagccctt ctacaagtac gacaaggccg gcaaccgcac ccagcaggtg     2760

aaggccgtgc gcgtggagca ggtgcagaag accggcgtgt gggtgcgcaa ccacaacggc     2820

atcgccgaca acgccaccat ggtgcgcgtg gacgtgttcg agaagggcga caagtactac     2880

ctggtgccca tctacagctg gcaggtggcc aagggcatcc tgcccgaccg cgccgtggtg     2940

cagggcaagg acgaggagga ctggcagctg atcgacgaca gcttcaactt caagttcagc     3000

ctgcacccca acgacctggt ggaggtgatc accaagaagg cccgcatgtt cggctacttc     3060

gccagctgcc accgcggcac cggcaacatc aacatccgca tccacgacct ggaccacaag     3120

atcggcaaga acggcatcct ggagggcatc ggcgtgaaga ccgccctgag cttccagaag     3180

taccagatcg acgagctggg caaggagatc cgcccctgcc gcctgaagaa gcgccctcct     3240

gtgcgcgcgg ccgcagatcc aaaaaagaag agaaaggtag atccaaaaaa gaagagaaag     3300

gtagatccaa aaaagaagag aaaggtagat acggccgcat ag                        3342


<210> 22
<211> 3468
<212> DNA
<213> Neisseria meningitidis

<400> 22
atggccgcct tcaagcccaa ccccatcaac tacatcctgg gcctggccat cggcatcgcc       60

agcgtgggct gggccatggt ggagatcgac gaggacgaga accccatctg cctgatcgac      120

ctgggtgtgc gcgtgttcga gcgcgctgag gtgcccaaga ctggtgacag tctggctatg      180

gctcgccggc ttgctcgctc tgttcggcgc cttactcgcc ggcgcgctca ccgccttctg      240

cgcgctcgcc gcctgctgaa gcgcgagggt gtgctgcagg ctgccgactt cgacgagaac      300

ggcctgatca agagcctgcc caacactcct tggcagctgc gcgctgccgc tctggaccgc      360

aagctgactc ctctggagtg gagcgccgtg ctgctgcacc tgatcaagca ccgcggctac      420

ctgagccagc gcaagaacga gggcgagacc gccgacaagg agctgggtgc tctgctgaag      480

ggcgtggccg acaacgccca cgccctgcag actggtgact tccgcactcc tgctgagctg      540

gccctgaaca agttcgagaa ggagagcggc cacatccgca accagcgcgg cgactacagc      600

cacaccttca gccgcaagga cctgcaggcc gagctgatcc tgctgttcga gaagcagaag      660

gagttcggca acccccacgt gagcggcggc ctgaaggagg gcatcgagac cctgctgatg      720

acccagcgcc ccgccctgag cggcgacgcc gtgcagaaga tgctgggcca ctgcaccttc      780

gagccagccg agcccaaggc cgccaagaac acctacaccg ccgagcgctt catctggctg      840

accaagctga acaacctgcg catcctggag cagggcagcg agcgccccct gaccgacacc      900

gagcgcgcca ccctgatgga cgagccctac cgcaagagca agctgaccta cgcccaggcc      960

cgcaagctgc tgggtctgga ggacaccgcc ttcttcaagg gcctgcgcta cggcaaggac     1020

aacgccgagg ccagcaccct gatggagatg aaggcctacc acgccatcag ccgcgccctg     1080

gagaaggagg gcctgaagga caagaagagt cctctgaacc tgagccccga gctgcaggac     1140

gagatcggca ccgccttcag cctgttcaag accgacgagg acatcaccgg ccgcctgaag     1200

gaccgcatcc agcccgagat cctggaggcc ctgctgaagc acatcagctt cgacaagttc     1260

gtgcagatca gcctgaaggc cctgcgccgc atcgtgcccc tgatggagca gggcaagcgc     1320

tacgacgagg cctgcgccga gatctacggc gaccactacg gcaagaagaa caccgaggag     1380

aagatctacc tgcctcctat ccccgccgac gagatccgca accccgtggt gctgcgcgcc     1440

ctgagccagg cccgcaaggt gatcaacggc gtggtgcgcc gctacggcag ccccgcccgc     1500

atccacatcg agaccgcccg cgaggtgggc aagagcttca aggaccgcaa ggagatcgag     1560

aagcgccagg aggagaaccg caaggaccgc gagaaggccg ccgccaagtt ccgcgagtac     1620

ttccccaact tcgtgggcga gcccaagagc aaggacatcc tgaagctgcg cctgtacgag     1680

cagcagcacg gcaagtgcct gtacagcggc aaggagatca acctgggccg cctgaacgag     1740

aagggctacg tggagatcgc cgctgccctg cccttcagcc gcacctggga cgacagcttc     1800

aacaacaagg tgctggtgct gggcagcgag gctcagaaca agggcaacca gaccccctac     1860

gagtacttca acggcaagga caacagccgc gagtggcagg agttcaaggc ccgcgtggag     1920

accagccgct tcccccgcag caagaagcag cgcatcctgc tgcagaagtt cgacgaggac     1980

ggcttcaagg agcgcaacct gaacgacacc cgctacgtga accgcttcct gtgccagttc     2040

gtggccgacc gcatgcgcct gaccggcaag ggcaagaagc gcgtgttcgc cagcaacggc     2100

cagatcacca acctgctgcg cggcttctgg ggcctgcgca aggtgcgcgc cgagaacgac     2160

cgccaccacg ccctggacgc cgtggtggtg gcctgcagca ccgtggccat gcagcagaag     2220

atcacccgct tcgtgcgcta caaggagatg aacgccttcg acggtaaaac catcgacaag     2280

gagaccggcg aggtgctgca ccagaagacc cacttccccc agccctggga gttcttcgcc     2340

caggaggtga tgatccgcgt gttcggcaag cccgacggca agcccgagtt cgaggaggcc     2400

gacacccccg agaagctgcg caccctgctg gccgagaagc tgagcagccg ccctgaggcc     2460

gtgcacgagt acgtgactcc tctgttcgtg agccgcgccc ccaaccgcaa gatgagcggt     2520

cagggtcaca tggagaccgt gaagagcgcc aagcgcctgg acgagggcgt gagcgtgctg     2580

cgcgtgcccc tgacccagct gaagctgaag gacctggaga agatggtgaa ccgcgagcgc     2640

gagcccaagc tgtacgaggc cctgaaggcc cgcctggagg cccacaagga cgaccccgcc     2700

aaggccttcg ccgagccctt ctacaagtac gacaaggccg gcaaccgcac ccagcaggtg     2760

aaggccgtgc gcgtggagca ggtgcagaag accggcgtgt gggtgcgcaa ccacaacggc     2820

atcgccgaca acgccaccat ggtgcgcgtg gacgtgttcg agaagggcga caagtactac     2880

ctggtgccca tctacagctg gcaggtggcc aagggcatcc tgcccgaccg cgccgtggtg     2940

cagggcaagg acgaggagga ctggcagctg atcgacgaca gcttcaactt caagttcagc     3000

ctgcacccca acgacctggt ggaggtgatc accaagaagg cccgcatgtt cggctacttc     3060

gccagctgcc accgcggcac cggcaacatc aacatccgca tccacgacct ggaccacaag     3120

atcggcaaga acggcatcct ggagggcatc ggcgtgaaga ccgccctgag cttccagaag     3180

taccagatcg acgagctggg caaggagatc cgcccctgcc gcctgaagaa gcgccctcct     3240

gtgcgcagca gggctgaccc caagaagaag aggaaggtgg aggccagcgg ttccggacgg     3300

gctgacgcat tggacgattt tgatctggat atgctgggaa gtgacgccct cgatgatttt     3360

gaccttgaca tgcttggttc ggatgccctt gatgactttg acctcgacat gctcggcagt     3420

gacgcccttg atgatttcga cctggacatg ctgattaact ctagatga                  3468


<210> 23
<211> 3489
<212> DNA
<213> Neisseria meningitidis

<400> 23
atgcccaaga agaagaggaa ggtggccgcc ttcaagccca accccatcaa ctacatcctg       60

ggcctggcca tcggcatcgc cagcgtgggc tgggccatgg tggagatcga cgaggacgag      120

aaccccatct gcctgatcga cctgggtgtg cgcgtgttcg agcgcgctga ggtgcccaag      180

actggtgaca gtctggctat ggctcgccgg cttgctcgct ctgttcggcg ccttactcgc      240

cggcgcgctc accgccttct gcgcgctcgc cgcctgctga agcgcgaggg tgtgctgcag      300

gctgccgact tcgacgagaa cggcctgatc aagagcctgc ccaacactcc ttggcagctg      360

cgcgctgccg ctctggaccg caagctgact cctctggagt ggagcgccgt gctgctgcac      420

ctgatcaagc accgcggcta cctgagccag cgcaagaacg agggcgagac cgccgacaag      480

gagctgggtg ctctgctgaa gggcgtggcc gacaacgccc acgccctgca gactggtgac      540

ttccgcactc ctgctgagct ggccctgaac aagttcgaga aggagagcgg ccacatccgc      600

aaccagcgcg gcgactacag ccacaccttc agccgcaagg acctgcaggc cgagctgatc      660

ctgctgttcg agaagcagaa ggagttcggc aacccccacg tgagcggcgg cctgaaggag      720

ggcatcgaga ccctgctgat gacccagcgc cccgccctga gcggcgacgc cgtgcagaag      780

atgctgggcc actgcacctt cgagccagcc gagcccaagg ccgccaagaa cacctacacc      840

gccgagcgct tcatctggct gaccaagctg aacaacctgc gcatcctgga gcagggcagc      900

gagcgccccc tgaccgacac cgagcgcgcc accctgatgg acgagcccta ccgcaagagc      960

aagctgacct acgcccaggc ccgcaagctg ctgggtctgg aggacaccgc cttcttcaag     1020

ggcctgcgct acggcaagga caacgccgag gccagcaccc tgatggagat gaaggcctac     1080

cacgccatca gccgcgccct ggagaaggag ggcctgaagg acaagaagag tcctctgaac     1140

ctgagccccg agctgcagga cgagatcggc accgccttca gcctgttcaa gaccgacgag     1200

gacatcaccg gccgcctgaa ggaccgcatc cagcccgaga tcctggaggc cctgctgaag     1260

cacatcagct tcgacaagtt cgtgcagatc agcctgaagg ccctgcgccg catcgtgccc     1320

ctgatggagc agggcaagcg ctacgacgag gcctgcgccg agatctacgg cgaccactac     1380

ggcaagaaga acaccgagga gaagatctac ctgcctccta tccccgccga cgagatccgc     1440

aaccccgtgg tgctgcgcgc cctgagccag gcccgcaagg tgatcaacgg cgtggtgcgc     1500

cgctacggca gccccgcccg catccacatc gagaccgccc gcgaggtggg caagagcttc     1560

aaggaccgca aggagatcga gaagcgccag gaggagaacc gcaaggaccg cgagaaggcc     1620

gccgccaagt tccgcgagta cttccccaac ttcgtgggcg agcccaagag caaggacatc     1680

ctgaagctgc gcctgtacga gcagcagcac ggcaagtgcc tgtacagcgg caaggagatc     1740

aacctgggcc gcctgaacga gaagggctac gtggagatcg ccgctgccct gcccttcagc     1800

cgcacctggg acgacagctt caacaacaag gtgctggtgc tgggcagcga ggctcagaac     1860

aagggcaacc agacccccta cgagtacttc aacggcaagg acaacagccg cgagtggcag     1920

gagttcaagg cccgcgtgga gaccagccgc ttcccccgca gcaagaagca gcgcatcctg     1980

ctgcagaagt tcgacgagga cggcttcaag gagcgcaacc tgaacgacac ccgctacgtg     2040

aaccgcttcc tgtgccagtt cgtggccgac cgcatgcgcc tgaccggcaa gggcaagaag     2100

cgcgtgttcg ccagcaacgg ccagatcacc aacctgctgc gcggcttctg gggcctgcgc     2160

aaggtgcgcg ccgagaacga ccgccaccac gccctggacg ccgtggtggt ggcctgcagc     2220

accgtggcca tgcagcagaa gatcacccgc ttcgtgcgct acaaggagat gaacgccttc     2280

gacggtaaaa ccatcgacaa ggagaccggc gaggtgctgc accagaagac ccacttcccc     2340

cagccctggg agttcttcgc ccaggaggtg atgatccgcg tgttcggcaa gcccgacggc     2400

aagcccgagt tcgaggaggc cgacaccccc gagaagctgc gcaccctgct ggccgagaag     2460

ctgagcagcc gccctgaggc cgtgcacgag tacgtgactc ctctgttcgt gagccgcgcc     2520

cccaaccgca agatgagcgg tcagggtcac atggagaccg tgaagagcgc caagcgcctg     2580

gacgagggcg tgagcgtgct gcgcgtgccc ctgacccagc tgaagctgaa ggacctggag     2640

aagatggtga accgcgagcg cgagcccaag ctgtacgagg ccctgaaggc ccgcctggag     2700

gcccacaagg acgaccccgc caaggccttc gccgagccct tctacaagta cgacaaggcc     2760

ggcaaccgca cccagcaggt gaaggccgtg cgcgtggagc aggtgcagaa gaccggcgtg     2820

tgggtgcgca accacaacgg catcgccgac aacgccacca tggtgcgcgt ggacgtgttc     2880

gagaagggcg acaagtacta cctggtgccc atctacagct ggcaggtggc caagggcatc     2940

ctgcccgacc gcgccgtggt gcagggcaag gacgaggagg actggcagct gatcgacgac     3000

agcttcaact tcaagttcag cctgcacccc aacgacctgg tggaggtgat caccaagaag     3060

gcccgcatgt tcggctactt cgccagctgc caccgcggca ccggcaacat caacatccgc     3120

atccacgacc tggaccacaa gatcggcaag aacggcatcc tggagggcat cggcgtgaag     3180

accgccctga gcttccagaa gtaccagatc gacgagctgg gcaaggagat ccgcccctgc     3240

cgcctgaaga agcgccctcc tgtgcgcagc agggctgacc ccaagaagaa gaggaaggtg     3300

gaggccagcg gttccggacg ggctgacgca ttggacgatt ttgatctgga tatgctggga     3360

agtgacgccc tcgatgattt tgaccttgac atgcttggtt cggatgccct tgatgacttt     3420

gacctcgaca tgctcggcag tgacgccctt gatgatttcg acctggacat gctgattaac     3480

tctagatga                                                             3489


<210> 24
<211> 3249
<212> DNA
<213> Neisseria meningitidis

<400> 24
atggctgcct tcaaacctaa ttcaatcaac tacatcctcg gcctcgatat cggcatcgca       60

tccgtcggct gggcgatggt agaaattgac gaagaagaaa accccatccg cctgattgat      120

ttgggcgtgc gcgtatttga gcgtgccgaa gtaccgaaaa caggcgactc ccttgccatg      180

gcaaggcgtt tggcgcgcag tgttcgccgc ctgacccgcc gtcgcgccca ccgcctgctt      240

cggacccgcc gcctattgaa acgcgaaggc gtattacaag ccgccaattt tgacgaaaac      300

ggcttgatta aatccttacc gaatacacca tggcaacttc gcgcagccgc attagaccgc      360

aaactgacgc ctttagagtg gtcggcagtc ttgttgcatt taatcaaaca tcgcggctat      420

ttatcgcaac ggaaaaacga gggcgaaact gccgataagg agcttggcgc tttgcttaaa      480

ggcgtagccg gcaatgccca tgccttacag acaggcgatt tccgcacacc ggccgaattg      540

gctttaaata aatttgagaa agaaagcggc catatccgca atcagcgcag cgattattcg      600

catacgttca gccgcaaaga tttacaggcg gagctgattt tgctgtttga aaaacaaaaa      660

gaatttggca atccgcatgt ttcaggcggc cttaaagaag gtattgaaac cctactgatg      720

acgcaacgcc ctgccctgtc cggcgatgcc gttcaaaaaa tgttggggca ttgcaccttc      780

gaaccggcag agccgaaagc cgctaaaaac acctacacag ccgaacgttt catctggctg      840

accaagctga acaacctgcg tattttagag caaggcagcg agcggccatt gaccgatacc      900

gaacgcgcca cgcttatgga cgagccatac agaaaatcca aactgactta cgcacaagcc      960

cgtaagctgc tgggtttaga agataccgcc tttttcaaag gcttgcgcta tggtaaagac     1020

aatgccgaag cctcaacatt gatggaaatg aaggcctacc atgccatcag ccgtgcactg     1080

gaaaaagaag gattgaaaga caaaaaatcc ccattaaacc tttctcccga attacaagac     1140

gaaatcggca cggcattctc cctgttcaaa accgatgaag acattacagg ccgtctgaaa     1200

gaccgtatac agcccgaaat cttagaagcg ctgttgaaac acatcagctt cgataagttc     1260

gtccaaattt ccttgaaagc attgcgccga attgtgcctc taatggaaca aggcaaacgt     1320

tacgatgaag cctgcgccga aatctacgga gaccattacg gcaagaagaa tacggaagaa     1380

aagatttatc tgccgccgat tcccgccgac gaaatccgca accccgtcgt cttgcgcgcc     1440

ttatctcaag cacgtaaggt cattaacggc gtggtacgcc gttacggctc cccagctcgt     1500

atccatattg aaactgcaag ggaagtaggt aaatcgttta aagaccgcaa agaaattgag     1560

aaacgccaag aagaaaaccg caaagaccgg gaaaaagccg ccgccaaatt ccgagagtat     1620

ttccccaatt ttgtcggaga acccaaatcc aaagatattc tgaaactgcg cctgtacgag     1680

caacaacacg gcaaatgcct gtattcgggc aaagaaatca acttaggccg tctgaacgaa     1740

aaaggctatg tcgaaatcga ccatgccctg ccgttctcgc gcacatggga cgacagtttc     1800

aacaataaag tactggtatt gggcagcgaa aaccaaaaca aaggcaatca aaccccttac     1860

gaatacttca acggcaaaga caacagccgc gaatggcagg aatttaaagc gcgtgtcgaa     1920

accagccgtt tcccgcgcag taaaaaacaa cggattctgc tgcaaaaatt cgatgaagac     1980

ggctttaaag aacgcaatct gaacgacacg cgctacgtca accgtttcct gtgtcaattt     2040

gttgccgacc gtatgcggct gacaggtaaa ggcaagaaac gtgtctttgc atccaacgga     2100

caaattacca atctgttgcg cggcttttgg ggattgcgca aagtgcgtgc ggaaaacgac     2160

cgccatcacg ccttggacgc cgtcgtcgtt gcctgctcga ccgttgccat gcagcagaaa     2220

attacccgtt ttgtacgcta taaagagatg aacgcgtttg acggtaaaac catagacaaa     2280

gaaacaggag aagtgctgca tcaaaaaaca cacttcccac aaccttggga atttttcgca     2340

caagaagtca tgattcgcgt cttcggcaaa ccggacggca aacccgaatt cgaagaagcc     2400

gataccctag aaaaactgcg cacgttgctt gccgaaaaat tatcatctcg ccccgaagcc     2460

gtacacgaat acgttacgcc actgtttgtt tcacgcgcgc ccaatcggaa gatgagcggg     2520

caagggcata tggagaccgt caaatccgcc aaacgactgg acgaaggcgt cagcgtgttg     2580

cgcgtaccgc tgacacagtt aaaactgaaa gacttggaaa aaatggtcaa tcgggagcgc     2640

gaacctaagc tatacgaagc actgaaagca cggctggaag cacataaaga cgatcctgcc     2700

aaagcctttg ccgagccgtt ttacaaatac gataaagcag gcaaccgcac ccaacaggta     2760

aaagccgtac gcgtagagca agtacagaaa accggcgtat gggtgcgcaa ccataacggt     2820

attgccgaca acgcaaccat ggtgcgcgta gatgtgtttg agaaaggcga caagtattat     2880

ctggtaccga tttacagttg gcaggtagcg aaagggattt tgccggatag ggctgttgta     2940

caaggaaaag atgaagaaga ttggcaactt attgatgata gtttcaactt taaattctca     3000

ttacacccta atgatttagt cgaggttata acaaaaaaag ctagaatgtt tggttacttt     3060

gccagctgcc atcgaggcac aggtaatatc aatatacgca ttcatgatct tgatcataaa     3120

attggcaaaa atggaatact ggaaggtatc ggcgtcaaaa ccgccctttc attccaaaaa     3180

taccaaattg acgaactggg caaagaaatc agaccatgcc gtctgaaaaa acgcccgcct     3240

gtccgttaa                                                             3249


<210> 25
<211> 4188
<212> DNA
<213> Treponema denticola

<400> 25
atgaaaaagg aaattaagga ttattttctc ggattggatg taggaaccgg atcggttggt       60

tgggcagtta ctgatactga ctataaactc ttaaaggcta atcgtaaaga cctttgggga      120

atgaggtgtt ttgagacggc ggaaactgcg gaagtgagaa ggcttcacag gggggctagg      180

cgccgtattg agagaagaaa aaaaagaata aagctgcttc aagagctttt ttcccaagaa      240

attgcaaaaa cagatgaggg atttttccaa agaatgaagg aaagcccttt ctatgcagaa      300

gacaagacta tattacagga aaacactctt tttaatgata aagattttgc cgataagacc      360

taccataaag cctatcctac cataaaccat ctgataaagg cttggattga aaacaaggta      420

aagccggatc caaggttatt atacttagcc tgtcataata ttataaaaaa aagaggtcat      480

tttttattcg agggcgattt cgattcagaa aatcagtttg atacttctat acaagccctt      540

tttgaatatc tgcgtgaaga tatggaagtc gatattgatg ccgatagcca aaaagtaaaa      600

gagattttaa aggatagctc tttaaaaaat tccgaaaaac aaagccgcct aaataagatt      660

ttaggactga aaccctccga caaacaaaaa aaagctatta ctaatttaat atcaggcaac      720

aaaataaact ttgccgatct ttatgataat ccggatttaa aggatgcgga gaaaaatagt      780

atatcttttt cgaaagatga ttttgatgct ttgagtgatg atcttgcttc cattctagga      840

gattcttttg agcttttatt aaaagcaaag gctgtatata actgctcggt tctttccaag      900

gtaataggcg atgaacagta tctttctttt gcaaaggtaa aaatatatga aaagcataaa      960

accgatttga ctaaattaaa aaatgttata aaaaagcatt tcccaaaaga ttataaaaaa     1020

gtattcggat acaataaaaa cgaaaaaaat aacaacaatt actccggata tgtaggcgta     1080

tgtaaaacca agagtaaaaa actaattata aacaattctg taaatcaaga agatttttac     1140

aaatttttaa aaactatcct ttcagcaaaa tccgagataa aggaagtaaa tgatatattg     1200

accgaaattg aaacagggac ttttttacct aaacagatat ctaaaagcaa tgcggagatt     1260

ccttatcaat tacgcaagat ggagctggaa aaaatattat caaacgcaga aaaacatttt     1320

tcctttttaa aacaaaaaga tgaaaaaggt ttatctcaca gtgaaaagat tataatgctt     1380

ttaacattta agattcctta ttatattgga cctataaacg ataaccataa aaaatttttt     1440

cccgatagat gctgggtagt aaaaaaagaa aaatcgcctt ccggtaaaac tactccatgg     1500

aacttttttg atcatatcga taaagaaaaa acagctgaag catttattac aagcagaacc     1560

aatttttgca catatttagt aggggaatcc gttttaccaa aaagttctct tttatattcc     1620

gagtataccg ttttaaatga aatcaacaat ttacagatta tcattgacgg aaaaaatatc     1680

tgcgatatta aactaaaaca aaaaatatac gaagatttat ttaaaaaata taaaaagatt     1740

acacaaaaac aaatttcaac ttttatcaaa cacgaaggta tttgcaataa aactgatgaa     1800

gtaattattc taggtatcga taaagaatgt acatcttcgt taaaatcata tatagaactt     1860

aaaaacatat tcggaaagca agtagatgaa atttctacaa agaatatgct tgaagaaatt     1920

atacgatggg ctactatcta tgatgaagga gaaggcaaaa caatacttaa aacaaaaata     1980

aaagccgaat atggaaaata ttgttctgat gaacagatca aaaaaattct aaatcttaaa     2040

ttttcaggtt ggggccgctt gtcacgcaaa ttccttgaaa ccgtcacatc agaaatgccg     2100

ggttttagcg aaccggtaaa tataataact gcaatgcggg aaactcaaaa taatttaatg     2160

gagttgctta gcagtgaatt tacatttact gaaaatatta aaaagataaa ttcgggattt     2220

gaagatgctg aaaagcaatt ttcatatgac ggtttggtta agcctctgtt tttatcacca     2280

tcggtaaaaa aaatgttgtg gcagactcta aagcttgtaa aagaaatatc gcatattacc     2340

caagcccctc ctaaaaaaat atttatagaa atggcaaagg gtgcagagct tgaacctgcg     2400

aggactaaga caagattaaa aattttacaa gacttataca ataactgtaa aaatgatgcg     2460

gatgctttta gttccgagat aaaagacctt tcaggtaaaa tagaaaatga agataattta     2520

aggcttcgaa gcgacaaact ttatctttat tacacgcagc ttggaaagtg catgtattgc     2580

ggtaaaccga ttgaaatagg ccatgtattt gatacaagca actatgatat agatcatatt     2640

tatccccaat ccaagattaa agatgacagt ataagtaatc gggttttagt atgcagcagc     2700

tgcaataaaa ataaggaaga taaatatcct ttgaagtctg aaattcaatc aaagcaaagg     2760

ggcttttgga attttttaca acgaaataac tttataagcc ttgaaaaatt gaataggtta     2820

acaagggcca ctccaatctc ggatgacgaa acggcaaaat tcattgccag acagcttgta     2880

gaaacaagac aggcgacaaa agtagctgca aaagtattag aaaaaatgtt tcccgaaact     2940

aagattgttt attctaaagc tgaaaccgta tcaatgttta gaaataaatt cgatattgta     3000

aaatgcagag aaataaacga ttttcatcat gctcatgatg catatttaaa tattgttgtc     3060

ggaaatgtat ataatacaaa atttacaaat aatccttgga actttataaa ggagaaacgg     3120

gataatccaa agattgccga tacttacaat tattataaag tttttgatta tgatgtaaaa     3180

agaaataata ttacggcatg ggaaaaagga aaaacaatta tcactgtgaa ggatatgctt     3240

aaaagaaata cccctattta tacacgccaa gccgcctgca aaaaaggaga actctttaac     3300

caaaccatta tgaaaaaagg attgggccag catcctctaa aaaaagaagg tcctttttct     3360

aatatttcaa aatatggggg ctataataaa gtctctgctg catattatac tcttatagaa     3420

tacgaagaaa aagggaataa aatacgaagc ttagaaacca tccctctata tttggtaaaa     3480

gacattcaaa aagatcaaga tgtattaaag agttacttaa cagatctgct agggaaaaaa     3540

gaatttaaga ttttggttcc taaaataaaa atcaactccc tcttaaaaat taacggtttc     3600

ccttgtcata taacagggaa aaccaatgat tctttcttac tgcgtccggc tgttcagttt     3660

tgctgttcaa ataatgaagt tctttatttt aaaaaaatta taagattcag tgaaataaga     3720

agtcaaagag aaaagatagg aaaaacaatt tctccttatg aagacttatc ctttagatct     3780

tatatcaaag aaaatttatg gaaaaagaca aaaaatgatg aaataggaga aaaggagttt     3840

tatgaccttc ttcaaaagaa gaatttggaa atctatgata tgcttttaac aaaacataag     3900

gatactattt ataaaaaaag acctaactct gcaactattg atatcttagt caaaggaaaa     3960

gaaaagttta aatctttaat aatcgaaaat cagtttgaag ttattttaga gattttaaaa     4020

ctgttttctg ccactagaaa tgtatcagac ttacaacata taggcggaag caaatattca     4080

ggagttgcaa agataggaaa taaaatatct agtcttgata actgtatttt aatttaccaa     4140

tcaataacag gtatttttga aaaaaggatt gatttgttaa aggtatga                  4188


<210> 26
<211> 4188
<212> DNA
<213> Treponema denticola

<400> 26
atgaagaagg agatcaagga ctacttcctg ggcctggacg tgggcaccgg cagcgtgggc       60

tgggccgtga ccgacaccga ctacaagctg ctgaaggcca accgcaagga cctgtggggc      120

atgcgctgct tcgagactgc tgagaccgcc gaggtgcgcc ggctgcaccg cggtgctcgc      180

cggcgcatcg agcgccgcaa gaagcgcatc aagctgctgc aggagctgtt cagccaggag      240

atcgccaaga ccgacgaggg cttcttccag cgcatgaagg agagcccctt ctacgccgag      300

gacaagacca tcctgcagga gaacaccctg ttcaacgaca aggacttcgc cgacaagacc      360

taccacaagg cctaccccac catcaaccac ctgatcaagg cctggatcga gaacaaggtg      420

aagcccgacc ctcgcctgct gtacctggcc tgccacaaca tcatcaagaa gcgcggccac      480

ttcctgttcg agggcgactt cgacagcgag aaccagttcg acaccagcat ccaggccctg      540

ttcgagtacc tgcgcgagga catggaggtg gacatcgacg ccgacagcca gaaggtgaag      600

gagatcctga aggacagcag cctgaagaac agcgagaagc agagccgcct gaacaagatc      660

ctgggcctga agcccagcga caagcagaag aaggccatca ccaacctgat cagcggcaac      720

aagatcaact tcgccgacct gtacgacaac cccgacctga aggacgccga gaagaacagc      780

atcagcttca gcaaggacga cttcgacgcc ctgagcgacg acctggccag catcctgggc      840

gacagcttcg agctgctgct gaaggccaag gccgtgtaca actgcagcgt gctgagcaag      900

gtgatcggcg acgagcagta cctgagcttc gccaaggtga agatctacga gaagcacaag      960

accgacctta ccaagctgaa gaacgtgatc aagaagcact tccccaagga ctacaagaag     1020

gtgttcggct acaacaagaa cgagaagaac aacaacaact acagcggcta cgtgggcgtg     1080

tgcaagacca agagcaagaa gctgatcatc aacaacagcg tgaaccagga ggacttctac     1140

aagttcctga agaccatcct gagcgccaag agcgagatca aggaggtgaa cgacatcctg     1200

accgagatcg agaccggcac cttcctgccc aagcagatca gcaagagcaa cgccgagatc     1260

ccctaccagc tgcgcaagat ggagctggag aagatcctga gcaacgccga gaagcacttc     1320

agcttcctga agcagaagga cgagaagggc ctgagccaca gcgagaagat catcatgctg     1380

ctgaccttca agatccccta ctacatcggc cccatcaacg acaaccacaa gaagttcttc     1440

cccgaccgct gctgggtggt gaagaaggag aagagcccca gcggcaagac caccccctgg     1500

aacttcttcg accacatcga caaggagaag accgccgagg ccttcatcac cagccgcacc     1560

aacttctgca catacctggt gggcgagagc gtgctgccca agagcagcct gctgtacagc     1620

gagtacaccg tgctgaacga gatcaacaac ctgcagatca tcatcgacgg caagaacatc     1680

tgcgacatca agctgaagca gaagatctac gaggacctgt tcaagaagta caagaagatc     1740

acccagaagc agatcagcac cttcatcaag cacgagggca tctgcaacaa gaccgacgag     1800

gtgatcatcc tgggcatcga caaggagtgc accagcagcc tgaagagcta catcgagctg     1860

aagaacatct tcggcaagca ggtggacgag atcagcacca agaacatgct ggaggagatc     1920

atccgctggg ccaccatcta cgacgagggc gagggcaaga ccatcctgaa gaccaagatc     1980

aaggccgagt acggcaagta ctgcagcgac gagcagatca agaagatcct gaacctgaag     2040

ttcagcggct ggggccgcct gagccgcaag ttcctggaga ccgtgaccag cgagatgccc     2100

ggcttcagcg agcccgtgaa catcatcacc gccatgcgcg agacccagaa caacctgatg     2160

gagctgctga gcagcgagtt caccttcacc gagaacatca agaagatcaa cagcggcttc     2220

gaggacgccg agaagcagtt cagctacgac ggcctggtga agcccctgtt cctgagcccc     2280

agcgtgaaga agatgctgtg gcagaccctg aagctggtga aggagatcag ccacatcacc     2340

caggctcctc ctaagaagat cttcatcgag atggccaagg gcgccgagct ggagcctgct     2400

cgcaccaaga cccgcctgaa gatcctgcag gacctgtaca acaactgcaa gaacgacgcc     2460

gacgcattca gcagcgagat caaggacctg agcggcaaga tcgagaacga ggacaacctg     2520

cgcctgcgca gcgacaagct gtacctgtac tacacccagc tgggcaagtg catgtactgc     2580

ggcaagccca tcgagatcgg ccacgtgttc gacaccagca actacgacat cgaccacatc     2640

tacccccaga gcaagatcaa ggacgacagc atcagcaacc gcgtgctggt gtgcagcagc     2700

tgcaacaaga acaaggagga caagtaccct ctgaagagcg agatccagag caagcagcgc     2760

ggcttctgga acttcctgca gcgcaacaac ttcatcagcc tggagaagct gaaccgcctg     2820

acccgcgcca cccccatcag cgacgacgag accgccaagt tcatcgcccg ccagctggtg     2880

gagactcgcc aagctaccaa ggtggccgcc aaggtgctgg agaagatgtt ccccgagacc     2940

aagatcgtgt acagcaaggc cgagaccgtg agcatgttcc gcaacaagtt cgacatcgtg     3000

aagtgccgcg agatcaacga cttccaccac gcccacgacg cctacctgaa catcgtggtg     3060

ggcaacgtgt acaacaccaa gttcaccaac aacccctgga atttcattaa ggagaagcgc     3120

gacaacccca agatcgccga cacctacaac tactacaagg tgttcgacta cgacgtgaag     3180

cgcaacaaca tcaccgcctg ggagaagggc aagaccatca tcaccgtgaa ggacatgctg     3240

aagcgcaaca cccccatcta cacccgccag gccgcctgca agaagggcga gctgttcaac     3300

cagaccatca tgaagaaggg cctgggccag caccccctga agaaggaggg ccccttcagc     3360

aacatcagca agtacggcgg ctacaacaag gtgagcgccg cctactacac cctgatcgag     3420

tacgaggaga agggcaacaa gatccgcagc ctggagacca tccccctgta cctggtgaag     3480

gacatccaga aggaccagga cgtgctgaag agctacctga ccgacctgct gggcaagaag     3540

gagttcaaga tcctggtgcc caagatcaag atcaacagcc tgctgaagat caacggcttc     3600

ccctgccaca tcaccggcaa gaccaacgac agcttcctgc tgcgccccgc cgtgcagttc     3660

tgctgcagca acaacgaggt gctgtacttc aagaagatca tccgcttcag cgagatccgc     3720

agccagcgcg agaagatcgg caagaccatc agcccctacg aggacctgag cttccgcagc     3780

tacatcaagg agaacctgtg gaagaagacc aagaacgacg agatcggcga gaaggagttc     3840

tacgacctgc tgcagaagaa gaacctggag atctacgaca tgctgctgac caagcacaag     3900

gacaccatct acaagaagcg ccccaacagc gccaccatcg acatcctggt gaagggcaag     3960

gagaagttca agagcctgat catcgagaac cagttcgagg tgatcctgga gatcctgaag     4020

ctgttcagcg ccacccgcaa cgtgagcgac ctgcagcaca tcggcggcag caagtacagc     4080

ggcgtggcca agatcggcaa caagatcagc agcctggaca actgcatcct gatctaccag     4140

agcatcaccg gcatcttcga gaagcgcatc gacctgctga aggtgtaa                  4188


<210> 27
<211> 4188
<212> DNA
<213> Treponema denticola

<400> 27
atgaagaagg agatcaagga ctacttcctg ggcctggccg tgggcaccgg cagcgtgggc       60

tgggccgtga ccgacaccga ctacaagctg ctgaaggcca accgcaagga cctgtggggc      120

atgcgctgct tcgagactgc tgagaccgcc gaggtgcgcc ggctgcaccg cggtgctcgc      180

cggcgcatcg agcgccgcaa gaagcgcatc aagctgctgc aggagctgtt cagccaggag      240

atcgccaaga ccgacgaggg cttcttccag cgcatgaagg agagcccctt ctacgccgag      300

gacaagacca tcctgcagga gaacaccctg ttcaacgaca aggacttcgc cgacaagacc      360

taccacaagg cctaccccac catcaaccac ctgatcaagg cctggatcga gaacaaggtg      420

aagcccgacc ctcgcctgct gtacctggcc tgccacaaca tcatcaagaa gcgcggccac      480

ttcctgttcg agggcgactt cgacagcgag aaccagttcg acaccagcat ccaggccctg      540

ttcgagtacc tgcgcgagga catggaggtg gacatcgacg ccgacagcca gaaggtgaag      600

gagatcctga aggacagcag cctgaagaac agcgagaagc agagccgcct gaacaagatc      660

ctgggcctga agcccagcga caagcagaag aaggccatca ccaacctgat cagcggcaac      720

aagatcaact tcgccgacct gtacgacaac cccgacctga aggacgccga gaagaacagc      780

atcagcttca gcaaggacga cttcgacgcc ctgagcgacg acctggccag catcctgggc      840

gacagcttcg agctgctgct gaaggccaag gccgtgtaca actgcagcgt gctgagcaag      900

gtgatcggcg acgagcagta cctgagcttc gccaaggtga agatctacga gaagcacaag      960

accgacctta ccaagctgaa gaacgtgatc aagaagcact tccccaagga ctacaagaag     1020

gtgttcggct acaacaagaa cgagaagaac aacaacaact acagcggcta cgtgggcgtg     1080

tgcaagacca agagcaagaa gctgatcatc aacaacagcg tgaaccagga ggacttctac     1140

aagttcctga agaccatcct gagcgccaag agcgagatca aggaggtgaa cgacatcctg     1200

accgagatcg agaccggcac cttcctgccc aagcagatca gcaagagcaa cgccgagatc     1260

ccctaccagc tgcgcaagat ggagctggag aagatcctga gcaacgccga gaagcacttc     1320

agcttcctga agcagaagga cgagaagggc ctgagccaca gcgagaagat catcatgctg     1380

ctgaccttca agatccccta ctacatcggc cccatcaacg acaaccacaa gaagttcttc     1440

cccgaccgct gctgggtggt gaagaaggag aagagcccca gcggcaagac caccccctgg     1500

aacttcttcg accacatcga caaggagaag accgccgagg ccttcatcac cagccgcacc     1560

aacttctgca catacctggt gggcgagagc gtgctgccca agagcagcct gctgtacagc     1620

gagtacaccg tgctgaacga gatcaacaac ctgcagatca tcatcgacgg caagaacatc     1680

tgcgacatca agctgaagca gaagatctac gaggacctgt tcaagaagta caagaagatc     1740

acccagaagc agatcagcac cttcatcaag cacgagggca tctgcaacaa gaccgacgag     1800

gtgatcatcc tgggcatcga caaggagtgc accagcagcc tgaagagcta catcgagctg     1860

aagaacatct tcggcaagca ggtggacgag atcagcacca agaacatgct ggaggagatc     1920

atccgctggg ccaccatcta cgacgagggc gagggcaaga ccatcctgaa gaccaagatc     1980

aaggccgagt acggcaagta ctgcagcgac gagcagatca agaagatcct gaacctgaag     2040

ttcagcggct ggggccgcct gagccgcaag ttcctggaga ccgtgaccag cgagatgccc     2100

ggcttcagcg agcccgtgaa catcatcacc gccatgcgcg agacccagaa caacctgatg     2160

gagctgctga gcagcgagtt caccttcacc gagaacatca agaagatcaa cagcggcttc     2220

gaggacgccg agaagcagtt cagctacgac ggcctggtga agcccctgtt cctgagcccc     2280

agcgtgaaga agatgctgtg gcagaccctg aagctggtga aggagatcag ccacatcacc     2340

caggctcctc ctaagaagat cttcatcgag atggccaagg gcgccgagct ggagcctgct     2400

cgcaccaaga cccgcctgaa gatcctgcag gacctgtaca acaactgcaa gaacgacgcc     2460

gacgcattca gcagcgagat caaggacctg agcggcaaga tcgagaacga ggacaacctg     2520

cgcctgcgca gcgacaagct gtacctgtac tacacccagc tgggcaagtg catgtactgc     2580

ggcaagccca tcgagatcgg ccacgtgttc gacaccagca actacgacat cgctgctatc     2640

tacccccaga gcaagatcaa ggacgacagc atcagcaacc gcgtgctggt gtgcagcagc     2700

tgcgccaaga acaaggagga caagtaccct ctgaagagcg agatccagag caagcagcgc     2760

ggcttctgga acttcctgca gcgcaacaac ttcatcagcc tggagaagct gaaccgcctg     2820

acccgcgcca cccccatcag cgacgacgag accgccaagt tcatcgcccg ccagctggtg     2880

gagactcgcc aagctaccaa ggtggccgcc aaggtgctgg agaagatgtt ccccgagacc     2940

aagatcgtgt acagcaaggc cgagaccgtg agcatgttcc gcaacaagtt cgacatcgtg     3000

aagtgccgcg agatcaacga cttccaccac gcccacgacg cctacctgaa catcgtggtg     3060

ggcaacgtgt acaacaccaa gttcaccaac aacccctgga atttcattaa ggagaagcgc     3120

gacaacccca agatcgccga cacctacaac tactacaagg tgttcgacta cgacgtgaag     3180

cgcaacaaca tcaccgcctg ggagaagggc aagaccatca tcaccgtgaa ggacatgctg     3240

aagcgcaaca cccccatcta cacccgccag gccgcctgca agaagggcga gctgttcaac     3300

cagaccatca tgaagaaggg cctgggccag caccccctga agaaggaggg ccccttcagc     3360

aacatcagca agtacggcgg ctacaacaag gtgagcgccg cctactacac cctgatcgag     3420

tacgaggaga agggcaacaa gatccgcagc ctggagacca tccccctgta cctggtgaag     3480

gacatccaga aggaccagga cgtgctgaag agctacctga ccgacctgct gggcaagaag     3540

gagttcaaga tcctggtgcc caagatcaag atcaacagcc tgctgaagat caacggcttc     3600

ccctgccaca tcaccggcaa gaccaacgac agcttcctgc tgcgccccgc cgtgcagttc     3660

tgctgcagca acaacgaggt gctgtacttc aagaagatca tccgcttcag cgagatccgc     3720

agccagcgcg agaagatcgg caagaccatc agcccctacg aggacctgag cttccgcagc     3780

tacatcaagg agaacctgtg gaagaagacc aagaacgacg agatcggcga gaaggagttc     3840

tacgacctgc tgcagaagaa gaacctggag atctacgaca tgctgctgac caagcacaag     3900

gacaccatct acaagaagcg ccccaacagc gccaccatcg acatcctggt gaagggcaag     3960

gagaagttca agagcctgat catcgagaac cagttcgagg tgatcctgga gatcctgaag     4020

ctgttcagcg ccacccgcaa cgtgagcgac ctgcagcaca tcggcggcag caagtacagc     4080

ggcgtggcca agatcggcaa caagatcagc agcctggaca actgcatcct gatctaccag     4140

agcatcaccg gcatcttcga gaagcgcatc gacctgctga aggtgtaa                  4188


<210> 28
<211> 1053
<212> PRT
<213> Streptococcus aureas

<400> 28
Met Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 
    50                  55                  60                  


Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 
65                  70                  75                  80  


Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 
            100                 105                 110         


Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 
        115                 120                 125             


Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala 
    130                 135                 140                 


Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 
145                 150                 155                 160 


Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 
                165                 170                 175     


Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln 
            180                 185                 190         


Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 
        195                 200                 205             


Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 
    210                 215                 220                 


Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 
225                 230                 235                 240 


Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 
                245                 250                 255     


Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 
            260                 265                 270         


Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 
        275                 280                 285             


Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu 
    290                 295                 300                 


Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 
305                 310                 315                 320 


Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 
                325                 330                 335     


Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala 
            340                 345                 350         


Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu 
        355                 360                 365             


Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 
    370                 375                 380                 


Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 
385                 390                 395                 400 


Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 
                405                 410                 415     


Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln 
            420                 425                 430         


Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 
        435                 440                 445             


Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile 
    450                 455                 460                 


Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 
465                 470                 475                 480 


Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys 
                485                 490                 495     


Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 
            500                 505                 510         


Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 
        515                 520                 525             


Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 
    530                 535                 540                 


Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro 
545                 550                 555                 560 


Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys 
                565                 570                 575     


Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu 
            580                 585                 590         


Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile 
        595                 600                 605             


Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 
    610                 615                 620                 


Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 
625                 630                 635                 640 


Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 
                645                 650                 655     


Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys 
            660                 665                 670         


Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp 
        675                 680                 685             


Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp 
    690                 695                 700                 


Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys 
705                 710                 715                 720 


Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys 
                725                 730                 735     


Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu 
            740                 745                 750         


Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp 
        755                 760                 765             


Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu 
785                 790                 795                 800 


Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu 
                805                 810                 815     


Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His 
            820                 825                 830         


Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly 
        835                 840                 845             


Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr 
    850                 855                 860                 


Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile 
865                 870                 875                 880 


Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp 
                885                 890                 895     


Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr 
            900                 905                 910         


Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val 
        915                 920                 925             


Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser 
    930                 935                 940                 


Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala 
945                 950                 955                 960 


Glu Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn Gly 
                965                 970                 975     


Glu Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg Ile 
            980                 985                 990         


Glu Val Asn Met Ile Asp Ile Thr  Tyr Arg Glu Tyr Leu  Glu Asn Met 
        995                 1000                 1005             


Asn Asp  Lys Arg Pro Pro Arg  Ile Ile Lys Thr Ile  Ala Ser Lys 
    1010                 1015                 1020             


Thr Gln  Ser Ile Lys Lys Tyr  Ser Thr Asp Ile Leu  Gly Asn Leu 
    1025                 1030                 1035             


Tyr Glu  Val Lys Ser Lys Lys  His Pro Gln Ile Ile  Lys Lys Gly 
    1040                 1045                 1050             


<210> 29
<211> 3162
<212> DNA
<213> Streptococcus aureas

<400> 29
atgaaaagga attatatctt aggattagat atcggaatta catcagtggg ttatggaatt       60

attgattatg aaactagaga tgtcatagat gcgggcgtac gtttatttaa agaggctaat      120

gttgaaaata atgaaggacg acgatcaaaa agaggtgcca gaaggcttaa gaggcgtcgt      180

agacatagaa tacaaagagt aaagaaactt ttatttgatt acaatttgtt gacagatcat      240

agtgagctaa gtggaatcaa tccttacgag gcgcgcgtaa agggattaag tcaaaaatta      300

agtgaagagg aattttctgc ggcattgcta catttagcaa agcgtagagg tgtacataat      360

gttaatgaag tggaagaaga tacaggtaat gaattatcca ctaaagaaca aatttcaaga      420

aatagtaaag cgttagaaga gaagtatgtt gcagaattac agttggaacg tttgaaaaaa      480

gacggtgaag tgagaggttc gattaaccgt ttcaaaacat ctgactatgt aaaagaagca      540

aagcagttat taaaagtaca aaaagcatat catcaacttg atcaatcatt tatagacact      600

tatattgatt tattggaaac aagaagaaca tattatgagg gaccaggtga aggtagccca      660

tttggatgga aagatattaa agaatggtat gaaatgttaa tgggacattg tacgtatttc      720

ccagaagaat tacgtagtgt gaaatatgcc tataatgctg atttatataa tgcgctgaat      780

gatttgaaca acttggttat tacacgagat gagaatgaga agctagagta ttatgaaaaa      840

ttccaaatta tcgagaatgt ctttaaacaa aagaaaaagc cgacgcttaa acaaattgcg      900

aaggaaatct tggtgaatga agaagacatc aaaggctatc gtgtcacaag tacaggtaaa      960

ccagaattta caaacttgaa agtttatcac gatatcaaag atattacagc aagaaaagaa     1020

attatcgaga atgcagagct actcgatcaa atagctaaaa tattaactat ttaccagtca     1080

tcagaagata tacaagaaga attaacaaac ctaaattcag aattgacaca agaagagatt     1140

gaacaaattt caaacttgaa aggttataca ggaactcata acctttcact aaaggcaata     1200

aatttaatat tagacgaatt gtggcatacg aacgataatc aaatagctat tttcaatcgt     1260

ttgaaacttg tacctaaaaa ggtagattta agccaacaaa aagaaattcc tactacttta     1320

gttgatgatt ttatactgtc tccagtagtg aaacgttcat ttatacaatc tattaaagtt     1380

attaacgcta ttattaaaaa atacggtttg ccaaatgata ttattattga acttgcgaga     1440

gaaaagaatt ctaaagatgc acaaaaaatg attaatgaaa tgcagaagag aaatcgtcaa     1500

acgaatgaac gtattgagga aattataaga acgacaggta aagaaaatgc taaatattta     1560

attgaaaaaa ttaagctgca cgatatgcaa gaagggaaat gtttatactc gttagaagca     1620

atccctctag aagatttact taataatcca ttcaattacg aagtagacca tatcattcca     1680

cgttctgttt ctttcgataa ctctttcaat aataaagtgt tggtgaaaca agaagaaaat     1740

agtaaaaaag gtaatagaac gccatttcaa tatttaagtt cttcagattc taaaataagt     1800

tatgagacat tcaaaaagca tattttaaat cttgctaaag gcaaaggtag aatctctaag     1860

acgaaaaaag aatatttgtt agaagaacga gatatcaatc gcttcagtgt ccaaaaagat     1920

tttattaacc gtaacttagt agatacacgc tatgcgacaa gagggttaat gaacttatta     1980

agatcttatt ttagagtgaa taacttagat gtcaaagtga aatcgattaa tggcggattc     2040

acaagtttct taagaaggaa atggaagttc aaaaaagaaa gaaataaggg ctacaaacac     2100

catgctgaag atgcactgat tattgcgaac gctgatttta ttttcaaaga atggaaaaaa     2160

ctagataaag ctaaaaaagt gatggaaaat caaatgtttg aagaaaagca agctgaaagt     2220

atgcctgaaa ttgagactga gcaagagtat aaagaaattt ttataacgcc tcatcaaatt     2280

aaacatatta aggattttaa agattataaa tattcacata gagttgataa aaagccgaat     2340

agagagttaa taaatgatac attatattct acgagaaaag atgacaaggg taatacatta     2400

atcgttaata acttaaatgg tttatacgat aaagataatg ataaattgaa aaaattaatt     2460

aataaatcac ctgaaaaatt attgatgtat catcatgatc cacaaacata tcaaaaatta     2520

aaattgatca tggaacaata tggcgatgag aaaaatccgc tttataaata ttatgaagaa     2580

acaggcaatt acttaacaaa atatagtaaa aaagataacg gaccagtcat caaaaaaatt     2640

aaatattatg gtaacaagct aaatgcgcat ttagatatta cggatgatta tccaaatagc     2700

agaaataaag tagtaaaact ttcattaaaa ccatatcgct ttgatgttta tttagataat     2760

ggggtatata aatttgtgac agttaaaaat ttagatgtta tcaaaaaaga aaactactat     2820

gaagttaatt caaagtgtta tgaagaagca aaaaaactga agaaaattag taatcaagca     2880

gaatttatcg caagttttta caataatgac ttgattaaga ttaacggaga attatataga     2940

gtcataggtg taaataatga tctacttaac agaattgaag taaatatgat agacatcaca     3000

tatagagaat atttagagaa catgaatgat aaaagaccac ctagaataat taaaacaata     3060

gcaagcaaaa cacaatctat taaaaagtat tctacagata ttctaggcaa tctttatgaa     3120

gtgaagagta aaaagcatcc tcaaatcata aagaaaggat ga                        3162


<210> 30
<211> 1629
<212> PRT
<213> Francisella tularensis

<400> 30
Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210> 31
<211> 4890
<212> DNA
<213> Francisella tularensis

<400> 31
atgaatttca aaatattgcc aatagcaata gatttaggtg ttaaaaatac tggtgtcttt       60

agcgcatttt atcaaaaagg aacttctctt gagagattgg ataataaaaa tggcaaagta      120

tatgaactat caaaagattc ttatacttta ttgatgaata atagaacagc aagaagacat      180

caaagaagag ggatagatag aaagcagcta gtcaaaaggc tctttaagct tatttggaca      240

gagcagctaa atttagagtg ggataaagac actcaacaag caattagctt tttatttaat      300

cgtagaggtt ttagttttat tactgatggt tattcgcctg aatatttaaa tattgttcca      360

gagcaagtaa aagcgatact tatggatata tttgatgatt acaacggtga agatgattta      420

gacagttatt taaaattagc tactgagcaa gaaagcaaaa tttctgaaat ttataacaag      480

ctaatgcaaa aaatattaga gtttaaatta atgaaattat gtactgatat taaggatgat      540

aaagtaagta ctaaaacgct taaagaaatc acaagctatg aatttgagtt attagctgat      600

tatttagcaa actatagcga gagtttaaaa acacaaaaat ttagttatac agataaacaa      660

ggtaatttaa aagagctaag ctactatcat catgataaat ataatattca agaatttcta      720

aagcgacatg ctactataaa tgatcgaatt ttagatactc ttttaactga tgatttagat      780

atttggaatt ttaattttga gaaatttgat tttgataaga atgaagaaaa gcttcagaat      840

caggaagata aagatcatat acaagcgcat ttacatcatt ttgtttttgc agtaaataaa      900

ataaaaagtg aaatggcaag tggtggtcgt catcgtagcc aatattttca agagataaca      960

aatgtgctag atgaaaataa tcatcaagag ggatatctca agaatttctg tgaaaatttg     1020

cataataaaa aatattcaaa tttaagtgtt aaaaatttag ttaatctaat tggtaaccta     1080

agtaatttag agctaaaacc gctaagaaaa tattttaatg acaaaattca cgcaaaagct     1140

gatcattggg atgagcaaaa gtttacagaa acttattgcc actggatatt aggagagtgg     1200

cgagtaggtg tcaaagatca agataagaaa gatggcgcta aatatagtta taaagatctg     1260

tgtaatgaat taaaacaaaa agttactaag gctggtttgg tagatttttt attagagtta     1320

gatccatgta gaactatacc accatatctg gataacaata accgtaaacc accaaaatgt     1380

caaagtttga ttttaaatcc gaagttttta gataatcaat atccaaactg gcaacaatat     1440

ttacaagaat taaagaaact acaaagtatt caaaattatt tagacagttt tgaaactgat     1500

ttaaaagtct taaagtcaag taaagatcaa ccatattttg ttgaatacaa gagttcaaat     1560

cagcaaatag caagtggtca aagagattat aaagatttag atgctcgaat attacagttt     1620

atatttgata gggtaaaagc tagtgatgag ttgcttttga atgagattta ttttcaggct     1680

aaaaaactta aacaaaaagc tagctctgag ttagaaaaac tcgagtcgag caaaaagcta     1740

gatgaagtta tagcaaatag tcaactatca cagatactaa agtctcaaca tacaaatggt     1800

atttttgaac agggtacttt tttgcatttg gtttgtaaat attataaaca aagacaaaga     1860

gcgagagact ctaggctata tattatgcct gaatatcgtt atgataaaaa actacataaa     1920

tataacaata caggcaggtt tgatgatgat aatcagctgc taacatattg taatcataag     1980

ccaagacaaa aaagatacca attgttaaat gatttagctg gggtgttgca ggtatcacct     2040

aattttttga aagataaaat tggttctgat gatgatctat ttattagcaa atggttggta     2100

gagcatatta gaggatttaa aaaagcttgt gaagatagtt taaaaataca aaaagacaat     2160

agaggattat taaatcataa aataaatata gctaggaata caaaaggcaa atgtgaaaaa     2220

gaaatattta atttaatatg taaaatagaa ggttcagaag ataaaaaagg taattacaag     2280

catggtttag cttacgaatt aggagtactt ttatttggtg aacctaatga agctagtaaa     2340

cctgagttcg atagaaaaat taaaaaattt aactcaatat acagttttgc acagattcaa     2400

caaattgctt ttgcagagcg taaaggcaat gctaacactt gtgcagtttg tagtgctgat     2460

aatgctcata gaatgcaaca aattaagatc actgagcctg tagaggacaa taaagataag     2520

ataatcttaa gtgccaaagc tcagagacta ccagcgattc caactagaat agttgacggt     2580

gcggttaaga aaatggcaac tatattagct aaaaatatag ttgatgataa ttggcagaat     2640

atcaaacaag ttttatcagc aaaacatcag ttacatatac ctattatcac agaatcaaat     2700

gcttttgagt ttgaaccagc attagctgat gtaaaaggta agagcctaaa agataggaga     2760

aaaaaagcat tagagagaat aagtcctgaa aatatattca aggataaaaa caatagaata     2820

aaagaatttg ctaaaggtat atcagcatat agtggtgcta atttaactga tggcgatttt     2880

gatggtgcaa aagaagaatt agatcatata atacctcgtt cacataaaaa atacggtact     2940

ctaaatgatg aagcaaatct aatttgtgta actcgtggtg ataataaaaa taaaggtaat     3000

agaattttct gcctacgtga tcttgcagat aactataaac taaaacagtt tgagacaact     3060

gatgatttag aaattgaaaa gaagatagct gatacaatct gggatgctaa caagaaagat     3120

tttaaatttg gtaattatcg tagttttatt aacctaacac cacaagagca gaaagcattt     3180

cgtcacgcgc tatttctggc tgatgaaaat cctatcaaac aagcagtcat aagagcgata     3240

aataatcgta atcgtacatt tgtaaatggc actcaacgct attttgcaga agtactggca     3300

aacaatatct atctaagggc taaaaaagaa aatctaaata cagataaaat ttcatttgat     3360

tattttggta ttccaactat aggtaatggt agaggtattg ctgaaatccg tcaactttat     3420

gaaaaagttg atagtgatat acaagcttat gcaaaaggtg ataaacctca agctagctac     3480

tctcacctaa tagatgcgat gctggctttt tgtattgctg ctgatgaaca cagaaatgat     3540

ggaagtatag gtctagaaat cgataaaaat tatagtttat atccattaga taaaaataca     3600

ggagaagtct ttaccaaaga tatttttagt caaattaaaa ttactgataa tgagtttagc     3660

gataaaaaat tagtaagaaa aaaagctata gagggcttta acacgcatag acaaatgact     3720

agagatggca tttatgcaga aaattaccta ccaatactaa tccataaaga actaaatgaa     3780

gttagaaaag gctatacttg gaaaaatagt gaagaaataa aaatattcaa aggtaaaaag     3840

tacgatatac aacaattgaa taaccttgtg tattgtctaa aatttgtaga taaacctata     3900

tctatagata tacaaattag taccttagaa gagttaagaa atatattaac aacaaataat     3960

atagctgcta cagcagaata ctattatata aatctaaaaa cccaaaaatt acatgagtat     4020

tatatcgaaa actataatac tgccttaggt tataaaaaat acagtaaaga aatggagttt     4080

ttgagaagct tagcttatcg tagcgaaagg gtaaaaatta aatcaataga tgatgtaaag     4140

caggttttgg ataaggatag taactttatc atcggtaaga ttactttacc atttaaaaaa     4200

gagtggcaaa gactatatcg tgagtggcaa aatacaacta tcaaagatga ttatgagttt     4260

ttaaaatcat tctttaatgt taaaagtatt actaagttgc ataaaaaagt tagaaaagat     4320

ttctctttac ctatttctac aaatgaaggt aaattcctgg tcaaaagaaa aacatgggat     4380

aacaatttta tctatcagat attaaatgat tctgattcta gagcagacgg aacaaagcca     4440

tttattccag cttttgacat ttctaaaaat gaaatagtcg aagccataat tgattcattt     4500

acatcaaaaa atattttttg gctgcctaaa aatatagaat tacaaaaggt ggataataaa     4560

aacatttttg ctatagatac tagtaaatgg ttcgaagtag aaacacctag tgatcttaga     4620

gacattggaa tagcaacaat tcaatacaag atagataata attctcgccc taaagtcaga     4680

gttaaacttg attatgttat cgatgatgat agtaagataa attattttat gaatcattct     4740

ttattaaaat caagatatcc tgacaaagtt ttagaaattt taaaacaatc aactattata     4800

gaatttgaaa gttcaggttt taataaaact atcaaagaaa tgcttggtat gaaattagca     4860

ggtatttata atgaaacatc taataattag                                      4890


<210> 32
<211> 3903
<212> DNA
<213> Francisella tularensis


<220>
<223> Francisella tularensis subsp. novicida (strain U112)

<400> 32
atgtcaattt atcaagaatt tgttaataaa tatagtttaa gtaaaactct aagatttgag       60

ttaatcccac agggtaaaac acttgaaaac ataaaagcaa gaggtttgat tttagatgat      120

gagaaaagag ctaaagacta caaaaaggct aaacaaataa ttgataaata tcatcagttt      180

tttatagagg agatattaag ttcggtttgt attagcgaag atttattaca aaactattct      240

gatgtttatt ttaaacttaa aaagagtgat gatgataatc tacaaaaaga ttttaaaagt      300

gcaaaagata cgataaagaa acaaatatct gaatatataa aggactcaga gaaatttaag      360

aatttgttta atcaaaacct tatcgatgct aaaaaagggc aagagtcaga tttaattcta      420

tggctaaagc aatctaagga taatggtata gaactattta aagccaatag tgatatcaca      480

gatatagatg aggcgttaga aataatcaaa tcttttaaag gttggacaac ttattttaag      540

ggttttcatg aaaatagaaa aaatgtttat agtagcaatg atattcctac atctattatt      600

tataggatag tagatgataa tttgcctaaa tttctagaaa ataaagctaa gtatgagagt      660

ttaaaagaca aagctccaga agctataaac tatgaacaaa ttaaaaaaga tttggcagaa      720

gagctaacct ttgatattga ctacaaaaca tctgaagtta atcaaagagt tttttcactt      780

gatgaagttt ttgagatagc aaactttaat aattatctaa atcaaagtgg tattactaaa      840

tttaatacta ttattggtgg taaatttgta aatggtgaaa atacaaagag aaaaggtata      900

aatgaatata taaatctata ctcacagcaa ataaatgata aaacactcaa aaaatataaa      960

atgagtgttt tatttaagca aattttaagt gatacagaat ctaaatcttt tgtaattgat     1020

aagttagaag atgatagtga tgtagttaca acgatgcaaa gtttttatga gcaaatagca     1080

gcttttaaaa cagtagaaga aaaatctatt aaagaaacac tatctttatt atttgatgat     1140

ttaaaagctc aaaaacttga tttgagtaaa atttatttta aaaatgataa atctcttact     1200

gatctatcac aacaagtttt tgatgattat agtgttattg gtacagcggt actagaatat     1260

ataactcaac aaatagcacc taaaaatctt gataacccta gtaagaaaga gcaagaatta     1320

atagccaaaa aaactgaaaa agcaaaatac ttatctctag aaactataaa gcttgcctta     1380

gaagaattta ataagcatag agatatagat aaacagtgta ggtttgaaga aatacttgca     1440

aactttgcgg ctattccgat gatatttgat gaaatagctc aaaacaaaga caatttggca     1500

cagatatcta tcaaatatca aaatcaaggt aaaaaagacc tacttcaagc tagtgcggaa     1560

gatgatgtta aagctatcaa ggatctttta gatcaaacta ataatctctt acataaacta     1620

aaaatatttc atattagtca gtcagaagat aaggcaaata ttttagacaa ggatgagcat     1680

ttttatctag tatttgagga gtgctacttt gagctagcga atatagtgcc tctttataac     1740

aaaattagaa actatataac tcaaaagcca tatagtgatg agaaatttaa gctcaatttt     1800

gagaactcga ctttggctaa tggttgggat aaaaataaag agcctgacaa tacggcaatt     1860

ttatttatca aagatgataa atattatctg ggtgtgatga ataagaaaaa taacaaaata     1920

tttgatgata aagctatcaa agaaaataaa ggcgagggtt ataaaaaaat tgtttataaa     1980

cttttacctg gcgcaaataa aatgttacct aaggttttct tttctgctaa atctataaaa     2040

ttttataatc ctagtgaaga tatacttaga ataagaaatc attccacaca tacaaaaaat     2100

ggtagtcctc aaaaaggata tgaaaaattt gagtttaata ttgaagattg ccgaaaattt     2160

atagattttt ataaacagtc tataagtaag catccggagt ggaaagattt tggatttaga     2220

ttttctgata ctcaaagata taattctata gatgaatttt atagagaagt tgaaaatcaa     2280

ggctacaaac taacttttga aaatatatca gagagctata ttgatagcgt agttaatcag     2340

ggtaaattgt acctattcca aatctataat aaagattttt cagcttatag caaagggcga     2400

ccaaatctac atactttata ttggaaagcg ctgtttgatg agagaaatct tcaagatgtg     2460

gtttataagc taaatggtga ggcagagctt ttttatcgta aacaatcaat acctaaaaaa     2520

atcactcacc cagctaaaga ggcaatagct aataaaaaca aagataatcc taaaaaagag     2580

agtgtttttg aatatgattt aatcaaagat aaacgcttta ctgaagataa gtttttcttt     2640

cactgtccta ttacaatcaa ttttaaatct agtggagcta ataagtttaa tgatgaaatc     2700

aatttattgc taaaagaaaa agcaaatgat gttcatatat taagtataga tagaggtgaa     2760

agacatttag cttactatac tttggtagat ggtaaaggca atatcatcaa acaagatact     2820

ttcaacatca ttggtaatga tagaatgaaa acaaactacc atgataagct tgctgcaata     2880

gagaaagata gggattcagc taggaaagac tggaaaaaga taaataacat caaagagatg     2940

aaagagggct atctatctca ggtagttcat gaaatagcta agctagttat agagtataat     3000

gctattgtgg tttttgagga tttaaatttt ggatttaaaa gagggcgttt caaggtagag     3060

aagcaggtct atcaaaagtt agaaaaaatg ctaattgaga aactaaacta tctagttttc     3120

aaagataatg agtttgataa aactggggga gtgcttagag cttatcagct aacagcacct     3180

tttgagactt ttaaaaagat gggtaaacaa acaggtatta tctactatgt accagctggt     3240

tttacttcaa aaatttgtcc tgtaactggt tttgtaaatc agttatatcc taagtatgaa     3300

agtgtcagca aatctcaaga gttctttagt aagtttgaca agatttgtta taaccttgat     3360

aagggctatt ttgagtttag ttttgattat aaaaactttg gtgacaaggc tgccaaaggc     3420

aagtggacta tagctagctt tgggagtaga ttgattaact ttagaaattc agataaaaat     3480

cataattggg atactcgaga agtttatcca actaaagagt tggagaaatt gctaaaagat     3540

tattctatcg aatatgggca tggcgaatgt atcaaagcag ctatttgcgg tgagagcgac     3600

aaaaagtttt ttgctaagct aactagtgtc ctaaatacta tcttacaaat gcgtaactca     3660

aaaacaggta ctgagttaga ttatctaatt tcaccagtag cagatgtaaa tggcaatttc     3720

tttgattcgc gacaggcgcc aaaaaatatg cctcaagatg ctgatgccaa tggtgcttat     3780

catattgggc taaaaggtct gatgctacta ggtaggatca aaaataatca agagggcaaa     3840

aaactcaatt tggttatcaa aaatgaagag tattttgagt tcgtgcagaa taggaataac     3900

taa                                                                   3903


<210> 33
<211> 1300
<212> PRT
<213> Francisella tularensis


<220>
<223> Francisella tularensis subsp. novicida (strain U112)

<400> 33
Met Ser Ile Tyr Gln Glu Phe Val Asn Lys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Glu Asn Ile Lys 
            20                  25                  30          


Ala Arg Gly Leu Ile Leu Asp Asp Glu Lys Arg Ala Lys Asp Tyr Lys 
        35                  40                  45              


Lys Ala Lys Gln Ile Ile Asp Lys Tyr His Gln Phe Phe Ile Glu Glu 
    50                  55                  60                  


Ile Leu Ser Ser Val Cys Ile Ser Glu Asp Leu Leu Gln Asn Tyr Ser 
65                  70                  75                  80  


Asp Val Tyr Phe Lys Leu Lys Lys Ser Asp Asp Asp Asn Leu Gln Lys 
                85                  90                  95      


Asp Phe Lys Ser Ala Lys Asp Thr Ile Lys Lys Gln Ile Ser Glu Tyr 
            100                 105                 110         


Ile Lys Asp Ser Glu Lys Phe Lys Asn Leu Phe Asn Gln Asn Leu Ile 
        115                 120                 125             


Asp Ala Lys Lys Gly Gln Glu Ser Asp Leu Ile Leu Trp Leu Lys Gln 
    130                 135                 140                 


Ser Lys Asp Asn Gly Ile Glu Leu Phe Lys Ala Asn Ser Asp Ile Thr 
145                 150                 155                 160 


Asp Ile Asp Glu Ala Leu Glu Ile Ile Lys Ser Phe Lys Gly Trp Thr 
                165                 170                 175     


Thr Tyr Phe Lys Gly Phe His Glu Asn Arg Lys Asn Val Tyr Ser Ser 
            180                 185                 190         


Asn Asp Ile Pro Thr Ser Ile Ile Tyr Arg Ile Val Asp Asp Asn Leu 
        195                 200                 205             


Pro Lys Phe Leu Glu Asn Lys Ala Lys Tyr Glu Ser Leu Lys Asp Lys 
    210                 215                 220                 


Ala Pro Glu Ala Ile Asn Tyr Glu Gln Ile Lys Lys Asp Leu Ala Glu 
225                 230                 235                 240 


Glu Leu Thr Phe Asp Ile Asp Tyr Lys Thr Ser Glu Val Asn Gln Arg 
                245                 250                 255     


Val Phe Ser Leu Asp Glu Val Phe Glu Ile Ala Asn Phe Asn Asn Tyr 
            260                 265                 270         


Leu Asn Gln Ser Gly Ile Thr Lys Phe Asn Thr Ile Ile Gly Gly Lys 
        275                 280                 285             


Phe Val Asn Gly Glu Asn Thr Lys Arg Lys Gly Ile Asn Glu Tyr Ile 
    290                 295                 300                 


Asn Leu Tyr Ser Gln Gln Ile Asn Asp Lys Thr Leu Lys Lys Tyr Lys 
305                 310                 315                 320 


Met Ser Val Leu Phe Lys Gln Ile Leu Ser Asp Thr Glu Ser Lys Ser 
                325                 330                 335     


Phe Val Ile Asp Lys Leu Glu Asp Asp Ser Asp Val Val Thr Thr Met 
            340                 345                 350         


Gln Ser Phe Tyr Glu Gln Ile Ala Ala Phe Lys Thr Val Glu Glu Lys 
        355                 360                 365             


Ser Ile Lys Glu Thr Leu Ser Leu Leu Phe Asp Asp Leu Lys Ala Gln 
    370                 375                 380                 


Lys Leu Asp Leu Ser Lys Ile Tyr Phe Lys Asn Asp Lys Ser Leu Thr 
385                 390                 395                 400 


Asp Leu Ser Gln Gln Val Phe Asp Asp Tyr Ser Val Ile Gly Thr Ala 
                405                 410                 415     


Val Leu Glu Tyr Ile Thr Gln Gln Ile Ala Pro Lys Asn Leu Asp Asn 
            420                 425                 430         


Pro Ser Lys Lys Glu Gln Glu Leu Ile Ala Lys Lys Thr Glu Lys Ala 
        435                 440                 445             


Lys Tyr Leu Ser Leu Glu Thr Ile Lys Leu Ala Leu Glu Glu Phe Asn 
    450                 455                 460                 


Lys His Arg Asp Ile Asp Lys Gln Cys Arg Phe Glu Glu Ile Leu Ala 
465                 470                 475                 480 


Asn Phe Ala Ala Ile Pro Met Ile Phe Asp Glu Ile Ala Gln Asn Lys 
                485                 490                 495     


Asp Asn Leu Ala Gln Ile Ser Ile Lys Tyr Gln Asn Gln Gly Lys Lys 
            500                 505                 510         


Asp Leu Leu Gln Ala Ser Ala Glu Asp Asp Val Lys Ala Ile Lys Asp 
        515                 520                 525             


Leu Leu Asp Gln Thr Asn Asn Leu Leu His Lys Leu Lys Ile Phe His 
    530                 535                 540                 


Ile Ser Gln Ser Glu Asp Lys Ala Asn Ile Leu Asp Lys Asp Glu His 
545                 550                 555                 560 


Phe Tyr Leu Val Phe Glu Glu Cys Tyr Phe Glu Leu Ala Asn Ile Val 
                565                 570                 575     


Pro Leu Tyr Asn Lys Ile Arg Asn Tyr Ile Thr Gln Lys Pro Tyr Ser 
            580                 585                 590         


Asp Glu Lys Phe Lys Leu Asn Phe Glu Asn Ser Thr Leu Ala Asn Gly 
        595                 600                 605             


Trp Asp Lys Asn Lys Glu Pro Asp Asn Thr Ala Ile Leu Phe Ile Lys 
    610                 615                 620                 


Asp Asp Lys Tyr Tyr Leu Gly Val Met Asn Lys Lys Asn Asn Lys Ile 
625                 630                 635                 640 


Phe Asp Asp Lys Ala Ile Lys Glu Asn Lys Gly Glu Gly Tyr Lys Lys 
                645                 650                 655     


Ile Val Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro Lys Val 
            660                 665                 670         


Phe Phe Ser Ala Lys Ser Ile Lys Phe Tyr Asn Pro Ser Glu Asp Ile 
        675                 680                 685             


Leu Arg Ile Arg Asn His Ser Thr His Thr Lys Asn Gly Ser Pro Gln 
    690                 695                 700                 


Lys Gly Tyr Glu Lys Phe Glu Phe Asn Ile Glu Asp Cys Arg Lys Phe 
705                 710                 715                 720 


Ile Asp Phe Tyr Lys Gln Ser Ile Ser Lys His Pro Glu Trp Lys Asp 
                725                 730                 735     


Phe Gly Phe Arg Phe Ser Asp Thr Gln Arg Tyr Asn Ser Ile Asp Glu 
            740                 745                 750         


Phe Tyr Arg Glu Val Glu Asn Gln Gly Tyr Lys Leu Thr Phe Glu Asn 
        755                 760                 765             


Ile Ser Glu Ser Tyr Ile Asp Ser Val Val Asn Gln Gly Lys Leu Tyr 
    770                 775                 780                 


Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Ala Tyr Ser Lys Gly Arg 
785                 790                 795                 800 


Pro Asn Leu His Thr Leu Tyr Trp Lys Ala Leu Phe Asp Glu Arg Asn 
                805                 810                 815     


Leu Gln Asp Val Val Tyr Lys Leu Asn Gly Glu Ala Glu Leu Phe Tyr 
            820                 825                 830         


Arg Lys Gln Ser Ile Pro Lys Lys Ile Thr His Pro Ala Lys Glu Ala 
        835                 840                 845             


Ile Ala Asn Lys Asn Lys Asp Asn Pro Lys Lys Glu Ser Val Phe Glu 
    850                 855                 860                 


Tyr Asp Leu Ile Lys Asp Lys Arg Phe Thr Glu Asp Lys Phe Phe Phe 
865                 870                 875                 880 


His Cys Pro Ile Thr Ile Asn Phe Lys Ser Ser Gly Ala Asn Lys Phe 
                885                 890                 895     


Asn Asp Glu Ile Asn Leu Leu Leu Lys Glu Lys Ala Asn Asp Val His 
            900                 905                 910         


Ile Leu Ser Ile Asp Arg Gly Glu Arg His Leu Ala Tyr Tyr Thr Leu 
        915                 920                 925             


Val Asp Gly Lys Gly Asn Ile Ile Lys Gln Asp Thr Phe Asn Ile Ile 
    930                 935                 940                 


Gly Asn Asp Arg Met Lys Thr Asn Tyr His Asp Lys Leu Ala Ala Ile 
945                 950                 955                 960 


Glu Lys Asp Arg Asp Ser Ala Arg Lys Asp Trp Lys Lys Ile Asn Asn 
                965                 970                 975     


Ile Lys Glu Met Lys Glu Gly Tyr Leu Ser Gln Val Val His Glu Ile 
            980                 985                 990         


Ala Lys Leu Val Ile Glu Tyr Asn  Ala Ile Val Val Phe  Glu Asp Leu 
        995                 1000                 1005             


Asn Phe  Gly Phe Lys Arg Gly  Arg Phe Lys Val Glu  Lys Gln Val 
    1010                 1015                 1020             


Tyr Gln  Lys Leu Glu Lys Met  Leu Ile Glu Lys Leu  Asn Tyr Leu 
    1025                 1030                 1035             


Val Phe  Lys Asp Asn Glu Phe  Asp Lys Thr Gly Gly  Val Leu Arg 
    1040                 1045                 1050             


Ala Tyr  Gln Leu Thr Ala Pro  Phe Glu Thr Phe Lys  Lys Met Gly 
    1055                 1060                 1065             


Lys Gln  Thr Gly Ile Ile Tyr  Tyr Val Pro Ala Gly  Phe Thr Ser 
    1070                 1075                 1080             


Lys Ile  Cys Pro Val Thr Gly  Phe Val Asn Gln Leu  Tyr Pro Lys 
    1085                 1090                 1095             


Tyr Glu  Ser Val Ser Lys Ser  Gln Glu Phe Phe Ser  Lys Phe Asp 
    1100                 1105                 1110             


Lys Ile  Cys Tyr Asn Leu Asp  Lys Gly Tyr Phe Glu  Phe Ser Phe 
    1115                 1120                 1125             


Asp Tyr  Lys Asn Phe Gly Asp  Lys Ala Ala Lys Gly  Lys Trp Thr 
    1130                 1135                 1140             


Ile Ala  Ser Phe Gly Ser Arg  Leu Ile Asn Phe Arg  Asn Ser Asp 
    1145                 1150                 1155             


Lys Asn  His Asn Trp Asp Thr  Arg Glu Val Tyr Pro  Thr Lys Glu 
    1160                 1165                 1170             


Leu Glu  Lys Leu Leu Lys Asp  Tyr Ser Ile Glu Tyr  Gly His Gly 
    1175                 1180                 1185             


Glu Cys  Ile Lys Ala Ala Ile  Cys Gly Glu Ser Asp  Lys Lys Phe 
    1190                 1195                 1200             


Phe Ala  Lys Leu Thr Ser Val  Leu Asn Thr Ile Leu  Gln Met Arg 
    1205                 1210                 1215             


Asn Ser  Lys Thr Gly Thr Glu  Leu Asp Tyr Leu Ile  Ser Pro Val 
    1220                 1225                 1230             


Ala Asp  Val Asn Gly Asn Phe  Phe Asp Ser Arg Gln  Ala Pro Lys 
    1235                 1240                 1245             


Asn Met  Pro Gln Asp Ala Asp  Ala Asn Gly Ala Tyr  His Ile Gly 
    1250                 1255                 1260             


Leu Lys  Gly Leu Met Leu Leu  Gly Arg Ile Lys Asn  Asn Gln Glu 
    1265                 1270                 1275             


Gly Lys  Lys Leu Asn Leu Val  Ile Lys Asn Glu Glu  Tyr Phe Glu 
    1280                 1285                 1290             


Phe Val  Gln Asn Arg Asn Asn  
    1295                 1300 


<210> 34
<211> 3924
<212> DNA
<213> Acidaminococcus sp.


<220>
<223> Acidaminococcus sp. (strain BV3L6)

<400> 34
atgacccaat ttgaaggttt taccaattta taccaagttt cgaagaccct tcgttttgaa       60

ctgattcccc aaggaaaaac actcaaacat atccaggagc aagggttcat tgaggaggat      120

aaagctcgca atgaccatta caaagagtta aaaccaatca ttgaccgcat ctataagact      180

tatgctgatc aatgtctcca actggtacag cttgactggg agaatctatc tgcagccata      240

gactcctatc gtaaggaaaa aaccgaagaa acacgaaatg cgctgattga ggagcaagca      300

acatatagaa atgcgattca tgactacttt ataggtcgga cggataatct gacagatgcc      360

ataaataagc gccatgctga aatctataaa ggacttttta aagctgaact tttcaatgga      420

aaagttttaa agcaattagg gaccgtaacc acgacagaac atgaaaatgc tctactccgt      480

tcgtttgaca aatttacgac ctatttttcc ggcttttatg aaaaccgaaa aaatgtcttt      540

agcgctgaag atatcagcac ggcaattccc catcgaatcg tccaggacaa tttccctaaa      600

tttaaggaaa actgccatat ttttacaaga ttgataaccg cagttccttc tttgcgggag      660

cattttgaaa atgtcaaaaa ggccattgga atctttgtta gtacgtctat tgaagaagtc      720

ttttcctttc ccttttataa tcaacttcta acccaaacgc aaattgatct ttataatcaa      780

cttctcggcg gcatatctag ggaagcaggc acagaaaaaa tcaagggact taatgaagtt      840

ctcaatctgg ctatccaaaa aaatgatgaa acagcccata taatcgcgtc cctgccgcat      900

cgttttattc ctctttttaa acaaattctt tccgatcgaa atacgttatc ctttattttg      960

gaagaattca aaagcgatga ggaagtcatc caatccttct gcaaatataa aaccctcttg     1020

agaaacgaaa atgtactgga gactgcagaa gcccttttca atgaattaaa ttccattgat     1080

ttgactcata tctttatttc ccataaaaag ttagaaacca tctcttcagc gctttgtgac     1140

cattgggata ccttgcgcaa tgcactttac gaaagacgga tttctgaact cactggcaaa     1200

ataacaaaaa gtgccaaaga aaaagttcaa aggtcattaa aacatgagga tataaatctc     1260

caagaaatta tttctgctgc aggaaaagaa ctatcagaag cattcaaaca aaaaacaagt     1320

gaaattcttt cccatgccca tgctgcactt gaccagcctc ttcccacaac attaaaaaaa     1380

caggaagaaa aagaaatcct caaatcacag ctcgattcgc ttttaggcct ttatcatctt     1440

cttgattggt ttgctgtcga tgaaagcaat gaagtcgacc cagaattctc agcacggctg     1500

acaggcatta aactagaaat ggaaccaagc ctttcgtttt ataataaagc aagaaattat     1560

gcgacaaaaa agccctattc ggtggaaaaa tttaaattga attttcaaat gccaaccctt     1620

gcctctggtt gggatgtcaa taaagaaaaa aataatggag ctattttatt cgtaaaaaat     1680

ggtctctatt accttggtat catgcctaaa cagaaggggc gctataaagc cctgtctttt     1740

gagccgacag aaaaaacatc agaaggattc gataagatgt actatgacta cttcccagat     1800

gccgcaaaaa tgattcctaa gtgttccact cagctaaagg ctgtaaccgc tcattttcaa     1860

actcatacca cccccattct tctctcaaat aatttcattg aacctcttga aatcacaaaa     1920

gaaatttatg acctgaacaa tcctgaaaag gagcctaaaa agtttcaaac ggcttatgca     1980

aagaagacag gcgatcaaaa aggctataga gaagcgcttt gcaaatggat tgactttacg     2040

cgggattttc tctctaaata tacgaaaaca acttcaatcg atttatcttc actccgccct     2100

tcttcgcaat ataaagattt aggggaatat tacgccgaac tgaatccgct tctctatcat     2160

atctccttcc aacgaattgc tgaaaaggaa atcatggatg ctgtagaaac gggaaaattg     2220

tatctgttcc aaatctacaa taaggatttt gcgaagggcc atcacgggaa accaaatctc     2280

cacaccctgt attggacagg tctcttcagt cctgaaaacc ttgcgaaaac cagcatcaaa     2340

cttaatggtc aagcagaatt gttctatcga cctaaaagcc gcatgaagcg gatggcccat     2400

cgtcttgggg aaaaaatgct gaacaaaaaa ctaaaggacc agaagacacc gattccagat     2460

accctctacc aagaactgta cgattatgtc aaccaccggc taagccatga tctttccgat     2520

gaagcaaggg ccctgcttcc aaatgttatc accaaagaag tctcccatga aattataaag     2580

gatcggcggt ttacttccga taaatttttc ttccatgttc ccattacact gaattatcaa     2640

gcagccaata gtcccagtaa attcaaccag cgtgtcaatg cctaccttaa ggagcatccg     2700

gaaacgccca tcattggtat cgatcgtgga gaacgcaatc taatctatat taccgtcatt     2760

gacagtactg ggaaaatttt ggagcagcgt tccctgaata ccatccagca atttgactac     2820

caaaaaaaat tggacaacag ggaaaaagag cgtgttgccg cccgtcaagc ctggtccgtc     2880

gtcggaacga tcaaagacct taaacaaggc tacttgtcac aggtcatcca tgaaattgta     2940

gacctgatga ttcattacca agctgttgtc gtccttgaaa acctcaactt cggatttaaa     3000

tcaaaacgga caggcattgc cgaaaaagca gtctaccaac aatttgaaaa gatgctaata     3060

gataaactca actgtttggt tctcaaagat tatcctgctg agaaagtggg aggcgtctta     3120

aacccgtatc aacttacaga tcagttcacg agctttgcaa aaatgggcac gcaaagcggc     3180

ttccttttct atgtaccggc cccttatacc tcaaagattg atcccctgac tggttttgtc     3240

gatccctttg tatggaagac cattaaaaat catgaaagtc ggaagcattt cctagaagga     3300

tttgatttcc tgcattatga tgtcaaaaca ggtgatttta tcctccattt taaaatgaat     3360

cggaatctct ctttccagag agggcttcct ggcttcatgc cagcttggga tattgttttc     3420

gaaaagaatg aaacccaatt tgatgcaaaa gggacgccct tcattgcagg aaaacgaatt     3480

gttcctgtaa tcgaaaatca tcgttttacg ggtcgttaca gagacctcta tcccgctaat     3540

gaactcattg cccttctgga agaaaaaggc attgtcttta gagacggaag taatatatta     3600

cccaaacttt tagaaaatga tgattctcat gcaattgata cgatggtcgc cttgattcgc     3660

agtgtactcc aaatgagaaa cagcaatgcc gcaacggggg aagactacat caactctccc     3720

gttagggatc tgaacggggt gtgtttcgac agtcgattcc aaaatccaga atggccaatg     3780

gatgcggatg ccaacggagc ttatcatatt gccttaaaag ggcagcttct tctgaaccac     3840

ctcaaagaaa gcaaagatct gaaattacaa aacggcatca gcaaccaaga ttggctggcc     3900

tacattcagg aactgagaaa ctga                                            3924


<210> 35
<211> 1307
<212> PRT
<213> Acidaminococcus sp.


<220>
<223> Acidaminococcus sp. (strain BV3L6)

<400> 35
Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Glu Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn 
    1295                 1300                 1305         


<210> 36
<211> 3741
<212> DNA
<213> Lachnospiraceae bacterium


<220>
<223> Lachnospiraceae bacterium (strain ND2006)

<400> 36
atgcttaaga atgttggaat tgataggtta gatgttgaaa aagggagaaa aaatatgtct       60

aaattagaga agtttacaaa ttgttactct ttgtcaaaaa cacttcgttt taaggcgatt      120

cctgttggaa aaacccaaga aaatattgat aataaaagat tgcttgtcga ggatgaaaaa      180

cgtgcagaag attataaggg ggttaaaaaa ttacttgata ggtattattt atcatttatt      240

aatgatgttc ttcattccat taaactaaag aatttaaata attatatttc gttgtttaga      300

aagaaaactc ggacggaaaa agaaaacaaa gaattagaaa atttagagat aaatttacgt      360

aaagaaatcg ctaaggcttt taagggtaat gaaggttata aatctttatt taagaaggat      420

attatcgaga cgatattgcc tgaatttctt gatgataaag atgaaattgc tttggttaat      480

tcatttaatg gatttacaac ggcatttacc ggtttttttg ataataggga aaatatgttt      540

tcggaagaag ctaaatcaac ctcaattgct tttcgttgta ttaatgagaa tttaacaaga      600

tatatatcaa atatggatat atttgaaaaa gttgatgcaa ttttcgataa gcatgaagta      660

caggaaataa aagaaaaaat tctaaacagt gattatgatg ttgaagattt cttcgaagga      720

gaatttttta attttgttct tacgcaagaa ggtatcgatg tttataacgc tataattggt      780

ggctttgtga cagaatccgg agaaaaaata aaaggattaa atgaatatat taatttatat      840

aatcagaaaa ctaagcaaaa attaccgaag tttaagcctt tatataaaca ggttttatca      900

gatagagagt cactttcttt ttatggcgaa ggttatacat ctgatgagga agttttagaa      960

gtatttagaa atactcttaa taagaattca gaaatatttt cttcaattaa gaaattggaa     1020

aagttattta aaaacttcga tgaatattca agtgcaggaa ttttcgtaaa aaatggaccg     1080

gctatttcta caatttctaa ggatatattt ggagagtgga atgtaattag agacaaatgg     1140

aatgcggagt acgatgatat acatttaaaa aagaaggctg tagtaacaga aaaatatgaa     1200

gatgacaggc gtaaatcatt caaaaaaata ggaagttttt cattggagca gttgcaagaa     1260

tacgctgatg ctgatctatc tgtggtagag aagttaaaag aaatcattat ccaaaaagtg     1320

gatgagatat ataaagttta tggctcgtca gaaaaattgt tcgatgctga ttttgtacta     1380

gaaaaatcgt taaaaaagaa tgatgcagtt gtagcaataa tgaaagattt actagattct     1440

gtgaagtctt ttgaaaatta tataaaagcc ttttttggag agggaaaaga aacaaatcga     1500

gatgaatcat tttatggtga ttttgttttg gcatatgaca ttcttttgaa agtggatcat     1560

atttatgatg caatacgaaa ttatgtgaca caaaaaccgt attcgaaaga taagtttaaa     1620

ttatattttc aaaacccgca atttatgggg ggctgggata aggataaaga gacagactat     1680

agggcaacta tacttagata tggctcaaag tattacttgg cgattatgga taaaaaatat     1740

gctaagtgct tgcaaaaaat agataaggat gatgtaaatg gaaactatga aaaaataaat     1800

tataagttgc ttccaggacc taataagatg cttccaaagg tgttttttag taagaagtgg     1860

atggcttatt ataatccgtc ggaagatatt caaaaaatat ataaaaatgg aacatttaaa     1920

aaaggagata tgtttaattt aaatgattgt cataaattaa ttgatttctt taaggattca     1980

atcagtcggt atccgaaatg gagtaacgca tatgatttta acttttctga gaccgagaaa     2040

tataaggata tagcaggttt ttacagagag gttgaagaac aaggatataa agtatcattt     2100

gaaagtgcgt ctaaaaaaga agttgataaa ttggtagaag aaggaaaatt atacatgttc     2160

caaatttata ataaagactt ttcggataaa agtcatggaa cgccaaatct tcatacaatg     2220

tattttaagt tgctgtttga tgaaaataat catggtcaaa ttaggctttc tggtggtgct     2280

gagctattca tgcgacgtgc aagtttgaaa aaggaagaat tagttgtgca tcctgccaat     2340

agcccgatag cgaataaaaa cccggataat ccaaagaaaa cgactacgtt gtcatatgat     2400

gtatacaagg acaaaagatt ttcggaagat cagtatgagt tgcatatacc tattgcaata     2460

aataaatgcc ctaaaaatat atttaagata aatacagagg ttagagtgct gctgaagcat     2520

gatgataatc cttatgttat aggaattgat aggggggaga gaaatttact ttacattgtg     2580

gtggttgatg gtaagggtaa tattgtggag caatattcgc tgaatgaaat aattaataat     2640

tttaatggaa ttagaattaa gacggattac cattcacttt tggataaaaa ggagaaggaa     2700

agatttgaag ctcgtcaaaa ttggacgtct atagaaaaca ttaaagaact aaaagccgga     2760

tatattagtc aggttgttca taagatatgt gagttggtag aaaaatatga tgcggtaatt     2820

gcacttgaag atttgaattc tggttttaag aatagtcgag ttaaagttga aaagcaagta     2880

tatcagaaat ttgaaaaaat gctgattgat aaacttaact atatggtaga taagaaatct     2940

aatccttgcg ctacgggtgg tgctctgaaa ggctatcaaa ttactaacaa gtttgagagt     3000

tttaagtcga tgagtacaca aaatggtttt attttttata ttccggcgtg gttgactagc     3060

aaaattgatc cgtcaacagg atttgtaaat ttgttgaaaa caaagtatac gagcattgca     3120

gattcaaaga aatttataag ttcttttgac agaattatgt atgtacctga agaagattta     3180

ttcgagtttg cattagatta taagaatttt tctcggacag acgcggatta tataaaaaaa     3240

tggaaactct atagctatgg taacaggatt agaatattta gaaatcctaa aaaaaataat     3300

gtatttgatt gggaagaggt atgtcttaca tcagcctata aggaactttt taataaatat     3360

gggattaatt atcagcaagg agatatacga gctctcttat gtgaacagag tgataaggca     3420

ttctatagct cttttatggc attaatgtca ctcatgctgc aaatgagaaa tagtataaca     3480

ggtaggacgg atgtagattt tttgatttca ccagtaaaaa attctgacgg tattttttat     3540

gattccagaa attatgaagc tcaggaaaat gcaatattac cgaaaaatgc agatgctaat     3600

ggggcttata atatcgcaag aaaagttttg tgggctatag gtcagtttaa aaaggctgaa     3660

gatgaaaaac ttgataaggt taaaattgca atatcaaata aggaatggct cgaatatgcg     3720

caaacaagtg ttaagcattg a                                               3741


<210> 37
<211> 1228
<212> PRT
<213> Lachnospiraceae bacterium


<220>
<223> Lachnospiraceae bacterium (strain ND2006)

<400> 37
Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp 
            20                  25                  30          


Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys 
        35                  40                  45              


Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp 
    50                  55                  60                  


Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu 
65                  70                  75                  80  


Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn 
                85                  90                  95      


Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn 
            100                 105                 110         


Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu 
        115                 120                 125             


Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe 
    130                 135                 140                 


Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn 
145                 150                 155                 160 


Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile 
                165                 170                 175     


Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys 
            180                 185                 190         


Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys 
        195                 200                 205             


Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe 
    210                 215                 220                 


Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile 
225                 230                 235                 240 


Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn 
                245                 250                 255     


Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys 
            260                 265                 270         


Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser 
        275                 280                 285             


Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe 
    290                 295                 300                 


Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys 
305                 310                 315                 320 


Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile 
                325                 330                 335     


Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe 
            340                 345                 350         


Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp 
        355                 360                 365             


Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp 
    370                 375                 380                 


Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu 
385                 390                 395                 400 


Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu 
                405                 410                 415     


Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser 
            420                 425                 430         


Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys 
        435                 440                 445             


Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys 
    450                 455                 460                 


Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr 
465                 470                 475                 480 


Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile 
                485                 490                 495     


Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr 
            500                 505                 510         


Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro 
        515                 520                 525             


Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala 
    530                 535                 540                 


Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys 
545                 550                 555                 560 


Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly 
                565                 570                 575     


Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
            580                 585                 590         


Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro 
        595                 600                 605             


Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly 
    610                 615                 620                 


Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys 
625                 630                 635                 640 


Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn 
                645                 650                 655     


Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu 
            660                 665                 670         


Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys 
        675                 680                 685             


Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile 
    690                 695                 700                 


Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His 
705                 710                 715                 720 


Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile 
                725                 730                 735     


Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys 
            740                 745                 750         


Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys 
        755                 760                 765             


Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr 
    770                 775                 780                 


Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro Ile 
785                 790                 795                 800 


Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu Val 
                805                 810                 815     


Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile Asp 
            820                 825                 830         


Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys Gly 
        835                 840                 845             


Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe Asn 
    850                 855                 860                 


Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys Glu 
865                 870                 875                 880 


Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn Ile 
                885                 890                 895     


Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile Cys 
            900                 905                 910         


Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu Asn 
        915                 920                 925             


Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr Gln 
    930                 935                 940                 


Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp Lys 
945                 950                 955                 960 


Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln Ile 
                965                 970                 975     


Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly Phe 
            980                 985                 990         


Ile Phe Tyr Ile Pro Ala Trp Leu  Thr Ser Lys Ile Asp  Pro Ser Thr 
        995                 1000                 1005             


Gly Phe  Val Asn Leu Leu Lys  Thr Lys Tyr Thr Ser  Ile Ala Asp 
    1010                 1015                 1020             


Ser Lys  Lys Phe Ile Ser Ser  Phe Asp Arg Ile Met  Tyr Val Pro 
    1025                 1030                 1035             


Glu Glu  Asp Leu Phe Glu Phe  Ala Leu Asp Tyr Lys  Asn Phe Ser 
    1040                 1045                 1050             


Arg Thr  Asp Ala Asp Tyr Ile  Lys Lys Trp Lys Leu  Tyr Ser Tyr 
    1055                 1060                 1065             


Gly Asn  Arg Ile Arg Ile Phe  Arg Asn Pro Lys Lys  Asn Asn Val 
    1070                 1075                 1080             


Phe Asp  Trp Glu Glu Val Cys  Leu Thr Ser Ala Tyr  Lys Glu Leu 
    1085                 1090                 1095             


Phe Asn  Lys Tyr Gly Ile Asn  Tyr Gln Gln Gly Asp  Ile Arg Ala 
    1100                 1105                 1110             


Leu Leu  Cys Glu Gln Ser Asp  Lys Ala Phe Tyr Ser  Ser Phe Met 
    1115                 1120                 1125             


Ala Leu  Met Ser Leu Met Leu  Gln Met Arg Asn Ser  Ile Thr Gly 
    1130                 1135                 1140             


Arg Thr  Asp Val Asp Phe Leu  Ile Ser Pro Val Lys  Asn Ser Asp 
    1145                 1150                 1155             


Gly Ile  Phe Tyr Asp Ser Arg  Asn Tyr Glu Ala Gln  Glu Asn Ala 
    1160                 1165                 1170             


Ile Leu  Pro Lys Asn Ala Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala 
    1175                 1180                 1185             


Arg Lys  Val Leu Trp Ala Ile  Gly Gln Phe Lys Lys  Ala Glu Asp 
    1190                 1195                 1200             


Glu Lys  Leu Asp Lys Val Lys  Ile Ala Ile Ser Asn  Lys Glu Trp 
    1205                 1210                 1215             


Leu Glu  Tyr Ala Gln Thr Ser  Val Lys His 
    1220                 1225             


<210> 38
<211> 1064
<212> PRT
<213> Bradyrhizobium sp.


<220>
<223> Bradyrhizobium sp. BTAi1

<400> 38
Met Lys Arg Thr Ser Leu Arg Ala Tyr Arg Leu Gly Val Asp Leu Gly 
1               5                   10                  15      


Ala Asn Ser Leu Gly Trp Phe Val Val Trp Leu Asp Asp His Gly Gln 
            20                  25                  30          


Pro Glu Gly Leu Gly Pro Gly Gly Val Arg Ile Phe Pro Asp Gly Arg 
        35                  40                  45              


Asn Pro Gln Ser Lys Gln Ser Asn Ala Ala Gly Arg Arg Leu Ala Arg 
    50                  55                  60                  


Ser Ala Arg Arg Arg Arg Asp Arg Tyr Leu Gln Arg Arg Gly Lys Leu 
65                  70                  75                  80  


Met Gly Leu Leu Val Lys His Gly Leu Met Pro Ala Asp Glu Pro Ala 
                85                  90                  95      


Arg Lys Arg Leu Glu Cys Leu Asp Pro Tyr Gly Leu Arg Ala Lys Ala 
            100                 105                 110         


Leu Asp Glu Val Leu Pro Leu His His Val Gly Arg Ala Leu Phe His 
        115                 120                 125             


Leu Asn Gln Arg Arg Gly Leu Phe Ala Asn Arg Ala Ile Glu Gln Gly 
    130                 135                 140                 


Asp Lys Asp Ala Ser Ala Ile Lys Ala Ala Ala Gly Arg Leu Gln Thr 
145                 150                 155                 160 


Ser Met Gln Ala Cys Gly Ala Arg Thr Leu Gly Glu Phe Leu Asn Arg 
                165                 170                 175     


Arg His Gln Leu Arg Ala Thr Val Arg Ala Arg Ser Pro Val Gly Gly 
            180                 185                 190         


Asp Val Gln Ala Arg Tyr Glu Phe Tyr Pro Thr Arg Ala Met Val Asp 
        195                 200                 205             


Ala Glu Phe Glu Ala Ile Trp Ala Ala Gln Ala Pro His His Pro Thr 
    210                 215                 220                 


Met Thr Ala Glu Ala His Asp Thr Ile Arg Glu Ala Ile Phe Ser Gln 
225                 230                 235                 240 


Arg Ala Met Lys Arg Pro Ser Ile Gly Lys Cys Ser Leu Asp Pro Ala 
                245                 250                 255     


Thr Ser Gln Asp Asp Val Asp Gly Phe Arg Cys Ala Trp Ser His Pro 
            260                 265                 270         


Leu Ala Gln Arg Phe Arg Ile Trp Gln Asp Val Arg Asn Leu Ala Val 
        275                 280                 285             


Val Glu Thr Gly Pro Thr Ser Ser Arg Leu Gly Lys Glu Asp Gln Asp 
    290                 295                 300                 


Lys Val Ala Arg Ala Leu Leu Gln Thr Asp Gln Leu Ser Phe Asp Glu 
305                 310                 315                 320 


Ile Arg Gly Leu Leu Gly Leu Pro Ser Asp Ala Arg Phe Asn Leu Glu 
                325                 330                 335     


Ser Asp Arg Arg Asp His Leu Lys Gly Asp Ala Thr Gly Ala Ile Leu 
            340                 345                 350         


Ser Ala Arg Arg His Phe Gly Pro Ala Trp His Asp Arg Ser Leu Asp 
        355                 360                 365             


Arg Gln Ile Asp Ile Val Ala Leu Leu Glu Ser Ala Leu Asp Glu Ala 
    370                 375                 380                 


Ala Ile Ile Ala Ser Leu Gly Thr Thr His Ser Leu Asp Glu Ala Ala 
385                 390                 395                 400 


Ala Gln Arg Ala Leu Ser Ala Leu Leu Pro Asp Gly Tyr Cys Arg Leu 
                405                 410                 415     


Gly Leu Arg Ala Ile Lys Arg Val Leu Pro Leu Met Glu Ala Gly Arg 
            420                 425                 430         


Thr Tyr Ala Glu Ala Ala Ser Ala Ala Gly Tyr Asp His Ala Leu Leu 
        435                 440                 445             


Pro Gly Gly Lys Leu Ser Pro Thr Gly Tyr Leu Pro Tyr Tyr Gly Gln 
    450                 455                 460                 


Trp Leu Gln Asn Asp Val Val Gly Ser Asp Asp Glu Arg Asp Thr Asn 
465                 470                 475                 480 


Glu Arg Arg Trp Gly Arg Leu Pro Asn Pro Thr Val His Ile Gly Ile 
                485                 490                 495     


Gly Gln Leu Arg Arg Val Val Asn Glu Leu Ile Arg Trp His Gly Pro 
            500                 505                 510         


Pro Ala Glu Ile Thr Val Glu Leu Thr Arg Asp Leu Lys Leu Ser Pro 
        515                 520                 525             


Arg Arg Leu Ala Glu Leu Glu Arg Glu Gln Ala Glu Asn Gln Arg Lys 
    530                 535                 540                 


Asn Asp Lys Arg Thr Ser Leu Leu Arg Lys Leu Gly Leu Pro Ala Ser 
545                 550                 555                 560 


Thr His Asn Leu Leu Lys Leu Arg Leu Trp Asp Glu Gln Gly Asp Val 
                565                 570                 575     


Ala Ser Glu Cys Pro Tyr Thr Gly Glu Ala Ile Gly Leu Glu Arg Leu 
            580                 585                 590         


Val Ser Asp Asp Val Asp Ile Asp His Leu Ile Pro Phe Ser Ile Ser 
        595                 600                 605             


Trp Asp Asp Ser Ala Ala Asn Lys Val Val Cys Met Arg Tyr Ala Asn 
    610                 615                 620                 


Arg Glu Lys Gly Asn Arg Thr Pro Phe Glu Ala Phe Gly His Arg Gln 
625                 630                 635                 640 


Gly Arg Pro Tyr Asp Trp Ala Asp Ile Ala Glu Arg Ala Ala Arg Leu 
                645                 650                 655     


Pro Arg Gly Lys Arg Trp Arg Phe Gly Pro Gly Ala Arg Ala Gln Phe 
            660                 665                 670         


Glu Glu Leu Gly Asp Phe Gln Ala Arg Leu Leu Asn Glu Thr Ser Trp 
        675                 680                 685             


Leu Ala Arg Val Ala Lys Gln Tyr Leu Ala Ala Val Thr His Pro His 
    690                 695                 700                 


Arg Ile His Val Leu Pro Gly Arg Leu Thr Ala Leu Leu Arg Ala Thr 
705                 710                 715                 720 


Trp Glu Leu Asn Asp Leu Leu Pro Gly Ser Asp Asp Arg Ala Ala Lys 
                725                 730                 735     


Ser Arg Lys Asp His Arg His His Ala Ile Asp Ala Leu Val Ala Ala 
            740                 745                 750         


Leu Thr Asp Gln Ala Leu Leu Arg Arg Met Ala Asn Ala His Asp Asp 
        755                 760                 765             


Thr Arg Arg Lys Ile Glu Val Leu Leu Pro Trp Pro Thr Phe Arg Ile 
    770                 775                 780                 


Asp Leu Glu Thr Arg Leu Lys Ala Met Leu Val Ser His Lys Pro Asp 
785                 790                 795                 800 


His Gly Leu Gln Ala Arg Leu His Glu Asp Thr Ala Tyr Gly Thr Val 
                805                 810                 815     


Glu His Pro Glu Thr Glu Asp Gly Ala Asn Leu Val Tyr Arg Lys Thr 
            820                 825                 830         


Phe Val Asp Ile Ser Glu Lys Glu Ile Asp Arg Ile Arg Asp Arg Arg 
        835                 840                 845             


Leu Arg Asp Leu Val Arg Ala His Val Ala Gly Glu Arg Gln Gln Gly 
    850                 855                 860                 


Lys Thr Leu Lys Ala Ala Val Leu Ser Phe Ala Gln Arg Arg Asp Ile 
865                 870                 875                 880 


Ala Gly His Pro Asn Gly Ile Arg His Val Arg Leu Thr Lys Ser Ile 
                885                 890                 895     


Lys Pro Asp Tyr Leu Val Pro Ile Arg Asp Lys Ala Gly Arg Ile Tyr 
            900                 905                 910         


Lys Ser Tyr Asn Ala Gly Glu Asn Ala Phe Val Asp Ile Leu Gln Ala 
        915                 920                 925             


Glu Ser Gly Arg Trp Ile Ala Arg Ala Thr Thr Val Phe Gln Ala Asn 
    930                 935                 940                 


Gln Ala Asn Glu Ser His Asp Ala Pro Ala Ala Gln Pro Ile Met Arg 
945                 950                 955                 960 


Val Phe Lys Gly Asp Met Leu Arg Ile Asp His Ala Gly Ala Glu Lys 
                965                 970                 975     


Phe Val Lys Ile Val Arg Leu Ser Pro Ser Asn Asn Leu Leu Tyr Leu 
            980                 985                 990         


Val Glu His His Gln Ala Gly Val  Phe Gln Thr Arg His  Asp Asp Pro 
        995                 1000                 1005             


Glu Asp  Ser Phe Arg Trp Leu  Phe Ala Ser Phe Asp  Lys Leu Arg 
    1010                 1015                 1020             


Glu Trp  Asn Ala Glu Leu Val  Arg Ile Asp Thr Leu  Gly Gln Pro 
    1025                 1030                 1035             


Trp Arg  Arg Lys Arg Gly Leu  Glu Thr Gly Ser Glu  Asp Ala Thr 
    1040                 1045                 1050             


Arg Ile  Gly Trp Thr Arg Pro  Lys Lys Trp Pro 
    1055                 1060                 


<210> 39
<211> 1035
<212> PRT
<213> Candidatus Puniceispirillum marinum

<400> 39
Met Arg Arg Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp Cys 
1               5                   10                  15      


Leu Leu Asp Leu Gly Asp Asp Gly Glu Pro Val Ser Ile Phe Arg Thr 
            20                  25                  30          


Gly Ala Arg Ile Phe Ser Asp Gly Arg Asp Pro Lys Ser Leu Gly Ser 
        35                  40                  45              


Leu Lys Ala Thr Arg Arg Glu Ala Arg Leu Thr Arg Arg Arg Arg Asp 
    50                  55                  60                  


Arg Phe Ile Gln Arg Gln Lys Asn Leu Ile Asn Ala Leu Val Lys Tyr 
65                  70                  75                  80  


Gly Leu Met Pro Ala Asp Glu Ile Gln Arg Gln Ala Leu Ala Tyr Lys 
                85                  90                  95      


Asp Pro Tyr Pro Ile Arg Lys Lys Ala Leu Asp Glu Ala Ile Asp Pro 
            100                 105                 110         


Tyr Glu Met Gly Arg Ala Ile Phe His Ile Asn Gln Arg Arg Gly Phe 
        115                 120                 125             


Lys Ser Asn Arg Lys Ser Ala Asp Asn Glu Ala Gly Val Val Lys Gln 
    130                 135                 140                 


Ser Ile Ala Asp Leu Glu Met Lys Leu Gly Glu Ala Gly Ala Arg Thr 
145                 150                 155                 160 


Ile Gly Glu Phe Leu Ala Asp Arg Gln Ala Thr Asn Asp Thr Val Arg 
                165                 170                 175     


Ala Arg Arg Leu Ser Gly Thr Asn Ala Leu Tyr Glu Phe Tyr Pro Asp 
            180                 185                 190         


Arg Tyr Met Leu Glu Gln Glu Phe Asp Thr Leu Trp Ala Lys Gln Ala 
        195                 200                 205             


Ala Phe Asn Pro Ser Leu Tyr Ile Glu Ala Ala Arg Glu Arg Leu Lys 
    210                 215                 220                 


Glu Ile Val Phe Phe Gln Arg Lys Leu Lys Pro Gln Glu Val Gly Arg 
225                 230                 235                 240 


Cys Ile Phe Leu Ser Asp Glu Asp Arg Ile Ser Lys Ala Leu Pro Ser 
                245                 250                 255     


Phe Gln Arg Phe Arg Ile Tyr Gln Glu Leu Ser Asn Leu Ala Trp Ile 
            260                 265                 270         


Asp His Asp Gly Val Ala His Arg Ile Thr Ala Ser Leu Ala Leu Arg 
        275                 280                 285             


Asp His Leu Phe Asp Glu Leu Glu His Lys Lys Lys Leu Thr Phe Lys 
    290                 295                 300                 


Ala Met Arg Ala Ile Leu Arg Lys Gln Gly Val Val Asp Tyr Pro Val 
305                 310                 315                 320 


Gly Phe Asn Leu Glu Ser Asp Asn Arg Asp His Leu Ile Gly Asn Leu 
                325                 330                 335     


Thr Ser Cys Ile Met Arg Asp Ala Lys Lys Met Ile Gly Ser Ala Trp 
            340                 345                 350         


Asp Arg Leu Asp Glu Glu Glu Gln Asp Ser Phe Ile Leu Met Leu Gln 
        355                 360                 365             


Asp Asp Gln Lys Gly Asp Asp Glu Val Arg Ser Ile Leu Thr Gln Gln 
    370                 375                 380                 


Tyr Gly Leu Ser Asp Asp Val Ala Glu Asp Cys Leu Asp Val Arg Leu 
385                 390                 395                 400 


Pro Asp Gly His Gly Ser Leu Ser Lys Lys Ala Ile Asp Arg Ile Leu 
                405                 410                 415     


Pro Val Leu Arg Asp Gln Gly Leu Ile Tyr Tyr Asp Ala Val Lys Glu 
            420                 425                 430         


Ala Gly Leu Gly Glu Ala Asn Leu Tyr Asp Pro Tyr Ala Ala Leu Ser 
        435                 440                 445             


Asp Lys Leu Asp Tyr Tyr Gly Lys Ala Leu Ala Gly His Val Met Gly 
    450                 455                 460                 


Ala Ser Gly Lys Phe Glu Asp Ser Asp Glu Lys Arg Tyr Gly Thr Ile 
465                 470                 475                 480 


Ser Asn Pro Thr Val His Ile Ala Leu Asn Gln Val Arg Ala Val Val 
                485                 490                 495     


Asn Glu Leu Ile Arg Leu His Gly Lys Pro Asp Glu Val Val Ile Glu 
            500                 505                 510         


Ile Gly Arg Asp Leu Pro Met Gly Ala Asp Gly Lys Arg Glu Leu Glu 
        515                 520                 525             


Arg Phe Gln Lys Glu Gly Arg Ala Lys Asn Glu Arg Ala Arg Asp Glu 
    530                 535                 540                 


Leu Lys Lys Leu Gly His Ile Asp Ser Arg Glu Ser Arg Gln Lys Phe 
545                 550                 555                 560 


Gln Leu Trp Glu Gln Leu Ala Lys Glu Pro Val Asp Arg Cys Cys Pro 
                565                 570                 575     


Phe Thr Gly Lys Met Met Ser Ile Ser Asp Leu Phe Ser Asp Lys Val 
            580                 585                 590         


Glu Ile Glu His Leu Leu Pro Phe Ser Leu Thr Leu Asp Asp Ser Met 
        595                 600                 605             


Ala Asn Lys Thr Val Cys Phe Arg Gln Ala Asn Arg Asp Lys Gly Asn 
    610                 615                 620                 


Arg Ala Pro Phe Asp Ala Phe Gly Asn Ser Pro Ala Gly Tyr Asp Trp 
625                 630                 635                 640 


Gln Glu Ile Leu Gly Arg Ser Gln Asn Leu Pro Tyr Ala Lys Arg Trp 
                645                 650                 655     


Arg Phe Leu Pro Asp Ala Met Lys Arg Phe Glu Ala Asp Gly Gly Phe 
            660                 665                 670         


Leu Glu Arg Gln Leu Asn Asp Thr Arg Tyr Ile Ser Arg Tyr Thr Thr 
        675                 680                 685             


Glu Tyr Ile Ser Thr Ile Ile Pro Lys Asn Lys Ile Trp Val Val Thr 
    690                 695                 700                 


Gly Arg Leu Thr Ser Leu Leu Arg Gly Phe Trp Gly Leu Asn Ser Ile 
705                 710                 715                 720 


Leu Arg Gly His Asn Thr Asp Asp Gly Thr Pro Ala Lys Lys Ser Arg 
                725                 730                 735     


Asp Asp His Arg His His Ala Ile Asp Ala Ile Val Val Gly Met Thr 
            740                 745                 750         


Ser Arg Gly Leu Leu Gln Lys Val Ser Lys Ala Ala Arg Arg Ser Glu 
        755                 760                 765             


Asp Leu Asp Leu Thr Arg Leu Phe Glu Gly Arg Ile Asp Pro Trp Asp 
    770                 775                 780                 


Gly Phe Arg Asp Glu Val Lys Lys His Ile Asp Ala Ile Ile Val Ser 
785                 790                 795                 800 


His Arg Pro Arg Lys Lys Ser Gln Gly Ala Leu His Asn Asp Thr Ala 
                805                 810                 815     


Tyr Gly Ile Val Glu His Ala Glu Asn Gly Ala Ser Thr Val Val His 
            820                 825                 830         


Arg Val Pro Ile Thr Ser Leu Gly Lys Gln Ser Asp Ile Glu Lys Val 
        835                 840                 845             


Arg Asp Pro Leu Ile Lys Ser Ala Leu Leu Asn Glu Thr Ala Gly Leu 
    850                 855                 860                 


Ser Gly Lys Ser Phe Glu Asn Ala Val Gln Lys Trp Cys Ala Asp Asn 
865                 870                 875                 880 


Ser Ile Lys Ser Leu Arg Ile Val Glu Thr Val Ser Ile Ile Pro Ile 
                885                 890                 895     


Thr Asp Lys Glu Gly Val Ala Tyr Lys Gly Tyr Lys Gly Asp Gly Asn 
            900                 905                 910         


Ala Tyr Met Asp Ile Tyr Gln Asp Pro Thr Ser Ser Lys Trp Lys Gly 
        915                 920                 925             


Glu Ile Val Ser Arg Phe Asp Ala Asn Gln Lys Gly Phe Ile Pro Ser 
    930                 935                 940                 


Trp Gln Ser Gln Phe Pro Thr Ala Arg Leu Ile Met Arg Leu Arg Ile 
945                 950                 955                 960 


Asn Asp Leu Leu Lys Leu Gln Asp Gly Glu Ile Glu Glu Ile Tyr Arg 
                965                 970                 975     


Val Gln Arg Leu Ser Gly Ser Lys Ile Leu Met Ala Pro His Thr Glu 
            980                 985                 990         


Ala Asn Val Asp Ala Arg Asp Arg  Asp Lys Asn Asp Thr  Phe Lys Leu 
        995                 1000                 1005             


Thr Ser  Lys Ser Pro Gly Lys  Leu Gln Ser Ala Ser  Ala Arg Lys 
    1010                 1015                 1020             


Val His  Ile Ser Pro Thr Gly  Leu Ile Arg Glu Gly  
    1025                 1030                 1035 


<210> 40
<211> 1358
<212> PRT
<213> Acidaminococcus sp.

<400> 40
Met Gly Lys Met Tyr Tyr Leu Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Tyr Ala Val Thr Asp Pro Ser Tyr His Leu Leu Lys Phe Lys Gly 
            20                  25                  30          


Glu Pro Met Trp Gly Ala His Val Phe Ala Ala Gly Asn Gln Ser Ala 
        35                  40                  45              


Glu Arg Arg Ser Phe Arg Thr Ser Arg Arg Arg Leu Asp Arg Arg Gln 
    50                  55                  60                  


Gln Arg Val Lys Leu Val Gln Glu Ile Phe Ala Pro Val Ile Ser Pro 
65                  70                  75                  80  


Ile Asp Pro Arg Phe Phe Ile Arg Leu His Glu Ser Ala Leu Trp Arg 
                85                  90                  95      


Asp Asp Val Ala Glu Thr Asp Lys His Ile Phe Phe Asn Asp Pro Thr 
            100                 105                 110         


Tyr Thr Asp Lys Glu Tyr Tyr Ser Asp Tyr Pro Thr Ile His His Leu 
        115                 120                 125             


Ile Val Asp Leu Met Glu Ser Ser Glu Lys His Asp Pro Arg Leu Val 
    130                 135                 140                 


Tyr Leu Ala Val Ala Trp Leu Val Ala His Arg Gly His Phe Leu Asn 
145                 150                 155                 160 


Glu Val Asp Lys Asp Asn Ile Gly Asp Val Leu Ser Phe Asp Ala Phe 
                165                 170                 175     


Tyr Pro Glu Phe Leu Ala Phe Leu Ser Asp Asn Gly Val Ser Pro Trp 
            180                 185                 190         


Val Cys Glu Ser Lys Ala Leu Gln Ala Thr Leu Leu Ser Arg Asn Ser 
        195                 200                 205             


Val Asn Asp Lys Tyr Lys Ala Leu Lys Ser Leu Ile Phe Gly Ser Gln 
    210                 215                 220                 


Lys Pro Glu Asp Asn Phe Asp Ala Asn Ile Ser Glu Asp Gly Leu Ile 
225                 230                 235                 240 


Gln Leu Leu Ala Gly Lys Lys Val Lys Val Asn Lys Leu Phe Pro Gln 
                245                 250                 255     


Glu Ser Asn Asp Ala Ser Phe Thr Leu Asn Asp Lys Glu Asp Ala Ile 
            260                 265                 270         


Glu Glu Ile Leu Gly Thr Leu Thr Pro Asp Glu Cys Glu Trp Ile Ala 
        275                 280                 285             


His Ile Arg Arg Leu Phe Asp Trp Ala Ile Met Lys His Ala Leu Lys 
    290                 295                 300                 


Asp Gly Arg Thr Ile Ser Glu Ser Lys Val Lys Leu Tyr Glu Gln His 
305                 310                 315                 320 


His His Asp Leu Thr Gln Leu Lys Tyr Phe Val Lys Thr Tyr Leu Ala 
                325                 330                 335     


Lys Glu Tyr Asp Asp Ile Phe Arg Asn Val Asp Ser Glu Thr Thr Lys 
            340                 345                 350         


Asn Tyr Val Ala Tyr Ser Tyr His Val Lys Glu Val Lys Gly Thr Leu 
        355                 360                 365             


Pro Lys Asn Lys Ala Thr Gln Glu Glu Phe Cys Lys Tyr Val Leu Gly 
    370                 375                 380                 


Lys Val Lys Asn Ile Glu Cys Ser Glu Ala Asp Lys Val Asp Phe Asp 
385                 390                 395                 400 


Glu Met Ile Gln Arg Leu Thr Asp Asn Ser Phe Met Pro Lys Gln Val 
                405                 410                 415     


Ser Gly Glu Asn Arg Val Ile Pro Tyr Gln Leu Tyr Tyr Tyr Glu Leu 
            420                 425                 430         


Lys Thr Ile Leu Asn Lys Ala Ala Ser Tyr Leu Pro Phe Leu Thr Gln 
        435                 440                 445             


Cys Gly Lys Asp Ala Ile Ser Asn Gln Asp Lys Leu Leu Ser Ile Met 
    450                 455                 460                 


Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu Arg Lys Asp Asn Ser 
465                 470                 475                 480 


Glu His Ala Trp Leu Glu Arg Lys Ala Gly Lys Ile Tyr Pro Trp Asn 
                485                 490                 495     


Phe Asn Asp Lys Val Asp Leu Asp Lys Ser Glu Glu Ala Phe Ile Arg 
            500                 505                 510         


Arg Met Thr Asn Thr Cys Thr Tyr Tyr Pro Gly Glu Asp Val Leu Pro 
        515                 520                 525             


Leu Asp Ser Leu Ile Tyr Glu Lys Phe Met Ile Leu Asn Glu Ile Asn 
    530                 535                 540                 


Asn Ile Arg Ile Asp Gly Tyr Pro Ile Ser Val Asp Val Lys Gln Gln 
545                 550                 555                 560 


Val Phe Gly Leu Phe Glu Lys Lys Arg Arg Val Thr Val Lys Asp Ile 
                565                 570                 575     


Gln Asn Leu Leu Leu Ser Leu Gly Ala Leu Asp Lys His Gly Lys Leu 
            580                 585                 590         


Thr Gly Ile Asp Thr Thr Ile His Ser Asn Tyr Asn Thr Tyr His His 
        595                 600                 605             


Phe Lys Ser Leu Met Glu Arg Gly Val Leu Thr Arg Asp Asp Val Glu 
    610                 615                 620                 


Arg Ile Val Glu Arg Met Thr Tyr Ser Asp Asp Thr Lys Arg Val Arg 
625                 630                 635                 640 


Leu Trp Leu Asn Asn Asn Tyr Gly Thr Leu Thr Ala Asp Asp Val Lys 
                645                 650                 655     


His Ile Ser Arg Leu Arg Lys His Asp Phe Gly Arg Leu Ser Lys Met 
            660                 665                 670         


Phe Leu Thr Gly Leu Lys Gly Val His Lys Glu Thr Gly Glu Arg Ala 
        675                 680                 685             


Ser Ile Leu Asp Phe Met Trp Asn Thr Asn Asp Asn Leu Met Gln Leu 
    690                 695                 700                 


Leu Ser Glu Cys Tyr Thr Phe Ser Asp Glu Ile Thr Lys Leu Gln Glu 
705                 710                 715                 720 


Ala Tyr Tyr Ala Lys Ala Gln Leu Ser Leu Asn Asp Phe Leu Asp Ser 
                725                 730                 735     


Met Tyr Ile Ser Asn Ala Val Lys Arg Pro Ile Tyr Arg Thr Leu Ala 
            740                 745                 750         


Val Val Asn Asp Ile Arg Lys Ala Cys Gly Thr Ala Pro Lys Arg Ile 
        755                 760                 765             


Phe Ile Glu Met Ala Arg Asp Gly Glu Ser Lys Lys Lys Arg Ser Val 
    770                 775                 780                 


Thr Arg Arg Glu Gln Ile Lys Asn Leu Tyr Arg Ser Ile Arg Lys Asp 
785                 790                 795                 800 


Phe Gln Gln Glu Val Asp Phe Leu Glu Lys Ile Leu Glu Asn Lys Ser 
                805                 810                 815     


Asp Gly Gln Leu Gln Ser Asp Ala Leu Tyr Leu Tyr Phe Ala Gln Leu 
            820                 825                 830         


Gly Arg Asp Met Tyr Thr Gly Asp Pro Ile Lys Leu Glu His Ile Lys 
        835                 840                 845             


Asp Gln Ser Phe Tyr Asn Ile Asp His Ile Tyr Pro Gln Ser Met Val 
    850                 855                 860                 


Lys Asp Asp Ser Leu Asp Asn Lys Val Leu Val Gln Ser Glu Ile Asn 
865                 870                 875                 880 


Gly Glu Lys Ser Ser Arg Tyr Pro Leu Asp Ala Ala Ile Arg Asn Lys 
                885                 890                 895     


Met Lys Pro Leu Trp Asp Ala Tyr Tyr Asn His Gly Leu Ile Ser Leu 
            900                 905                 910         


Lys Lys Tyr Gln Arg Leu Thr Arg Ser Thr Pro Phe Thr Asp Asp Glu 
        915                 920                 925             


Lys Trp Asp Phe Ile Asn Arg Gln Leu Val Glu Thr Arg Gln Ser Thr 
    930                 935                 940                 


Lys Ala Leu Ala Ile Leu Leu Lys Arg Lys Phe Pro Asp Thr Glu Ile 
945                 950                 955                 960 


Val Tyr Ser Lys Ala Gly Leu Ser Ser Asp Phe Arg His Glu Phe Gly 
                965                 970                 975     


Leu Val Lys Ser Arg Asn Ile Asn Asp Leu His His Ala Lys Asp Ala 
            980                 985                 990         


Phe Leu Ala Ile Val Thr Gly Asn  Val Tyr His Glu Arg  Phe Asn Arg 
        995                 1000                 1005             


Arg Trp  Phe Met Val Asn Gln  Pro Tyr Ser Val Lys  Thr Lys Thr 
    1010                 1015                 1020             


Leu Phe  Thr His Ser Ile Lys  Asn Gly Asn Phe Val  Ala Trp Asn 
    1025                 1030                 1035             


Gly Glu  Glu Asp Leu Gly Arg  Ile Val Lys Met Leu  Lys Gln Asn 
    1040                 1045                 1050             


Lys Asn  Thr Ile His Phe Thr  Arg Phe Ser Phe Asp  Arg Lys Glu 
    1055                 1060                 1065             


Gly Leu  Phe Asp Ile Gln Pro  Leu Lys Ala Ser Thr  Gly Leu Val 
    1070                 1075                 1080             


Pro Arg  Lys Ala Gly Leu Asp  Val Val Lys Tyr Gly  Gly Tyr Asp 
    1085                 1090                 1095             


Lys Ser  Thr Ala Ala Tyr Tyr  Leu Leu Val Arg Phe  Thr Leu Glu 
    1100                 1105                 1110             


Asp Lys  Lys Thr Gln His Lys  Leu Met Met Ile Pro  Val Glu Gly 
    1115                 1120                 1125             


Leu Tyr  Lys Ala Arg Ile Asp  His Asp Lys Glu Phe  Leu Thr Asp 
    1130                 1135                 1140             


Tyr Ala  Gln Thr Thr Ile Ser  Glu Ile Leu Gln Lys  Asp Lys Gln 
    1145                 1150                 1155             


Lys Val  Ile Asn Ile Met Phe  Pro Met Gly Thr Arg  His Ile Lys 
    1160                 1165                 1170             


Leu Asn  Ser Met Ile Ser Ile  Asp Gly Phe Tyr Leu  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ser Ser Lys Gly Lys  Ser Val Leu Cys His  Ala Met Val 
    1190                 1195                 1200             


Pro Leu  Ile Val Pro His Lys  Ile Glu Cys Tyr Ile  Lys Ala Met 
    1205                 1210                 1215             


Glu Ser  Phe Ala Arg Lys Phe  Lys Glu Asn Asn Lys  Leu Arg Ile 
    1220                 1225                 1230             


Val Glu  Lys Phe Asp Lys Ile  Thr Val Glu Asp Asn  Leu Asn Leu 
    1235                 1240                 1245             


Tyr Glu  Leu Phe Leu Gln Lys  Leu Gln His Asn Pro  Tyr Asn Lys 
    1250                 1255                 1260             


Phe Phe  Ser Thr Gln Phe Asp  Val Leu Thr Asn Gly  Arg Ser Thr 
    1265                 1270                 1275             


Phe Thr  Lys Leu Ser Pro Glu  Glu Gln Val Gln Thr  Leu Leu Asn 
    1280                 1285                 1290             


Ile Leu  Ser Ile Phe Lys Thr  Cys Arg Ser Ser Gly  Cys Asp Leu 
    1295                 1300                 1305             


Lys Ser  Ile Asn Gly Ser Ala  Gln Ala Ala Arg Ile  Met Ile Ser 
    1310                 1315                 1320             


Ala Asp  Leu Thr Gly Leu Ser  Lys Lys Tyr Ser Asp  Ile Arg Leu 
    1325                 1330                 1335             


Val Glu  Gln Ser Ala Ser Gly  Leu Phe Val Ser Lys  Ser Gln Asn 
    1340                 1345                 1350             


Leu Leu  Glu Tyr Leu 
    1355             


<210> 41
<211> 1358
<212> PRT
<213> Acidaminococcus sp.


<220>
<223> Acidaminococcus sp. D21

<400> 41
Met Gly Lys Met Tyr Tyr Leu Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Tyr Ala Val Thr Asp Pro Ser Tyr His Leu Leu Lys Phe Lys Gly 
            20                  25                  30          


Glu Pro Met Trp Gly Ala His Val Phe Ala Ala Gly Asn Gln Ser Ala 
        35                  40                  45              


Glu Arg Arg Ser Phe Arg Thr Ser Arg Arg Arg Leu Asp Arg Arg Gln 
    50                  55                  60                  


Gln Arg Val Lys Leu Val Gln Glu Ile Phe Ala Pro Val Ile Ser Pro 
65                  70                  75                  80  


Ile Asp Pro Arg Phe Phe Ile Arg Leu His Glu Ser Ala Leu Trp Arg 
                85                  90                  95      


Asp Asp Val Ala Glu Thr Asp Lys His Ile Phe Phe Asn Asp Pro Thr 
            100                 105                 110         


Tyr Thr Asp Lys Glu Tyr Tyr Ser Asp Tyr Pro Thr Ile His His Leu 
        115                 120                 125             


Ile Val Asp Leu Met Glu Ser Ser Glu Lys His Asp Pro Arg Leu Val 
    130                 135                 140                 


Tyr Leu Ala Val Ala Trp Leu Val Ala His Arg Gly His Phe Leu Asn 
145                 150                 155                 160 


Glu Val Asp Lys Asp Asn Ile Gly Asp Val Leu Ser Phe Asp Ala Phe 
                165                 170                 175     


Tyr Pro Glu Phe Leu Ala Phe Leu Ser Asp Asn Gly Val Ser Pro Trp 
            180                 185                 190         


Val Cys Glu Ser Lys Ala Leu Gln Ala Thr Leu Leu Ser Arg Asn Ser 
        195                 200                 205             


Val Asn Asp Lys Tyr Lys Ala Leu Lys Ser Leu Ile Phe Gly Ser Gln 
    210                 215                 220                 


Lys Pro Glu Asp Asn Phe Asp Ala Asn Ile Ser Glu Asp Gly Leu Ile 
225                 230                 235                 240 


Gln Leu Leu Ala Gly Lys Lys Val Lys Val Asn Lys Leu Phe Pro Gln 
                245                 250                 255     


Glu Ser Asn Asp Ala Ser Phe Thr Leu Asn Asp Lys Glu Asp Ala Ile 
            260                 265                 270         


Glu Glu Ile Leu Gly Thr Leu Thr Pro Asp Glu Cys Glu Trp Ile Ala 
        275                 280                 285             


His Ile Arg Arg Leu Phe Asp Trp Ala Ile Met Lys His Ala Leu Lys 
    290                 295                 300                 


Asp Gly Arg Thr Ile Ser Glu Ser Lys Val Lys Leu Tyr Glu Gln His 
305                 310                 315                 320 


His His Asp Leu Thr Gln Leu Lys Tyr Phe Val Lys Thr Tyr Leu Ala 
                325                 330                 335     


Lys Glu Tyr Asp Asp Ile Phe Arg Asn Val Asp Ser Glu Thr Thr Lys 
            340                 345                 350         


Asn Tyr Val Ala Tyr Ser Tyr His Val Lys Glu Val Lys Gly Thr Leu 
        355                 360                 365             


Pro Lys Asn Lys Ala Thr Gln Glu Glu Phe Cys Lys Tyr Val Leu Gly 
    370                 375                 380                 


Lys Val Lys Asn Ile Glu Cys Ser Glu Ala Asp Lys Val Asp Phe Asp 
385                 390                 395                 400 


Glu Met Ile Gln Arg Leu Thr Asp Asn Ser Phe Met Pro Lys Gln Val 
                405                 410                 415     


Ser Gly Glu Asn Arg Val Ile Pro Tyr Gln Leu Tyr Tyr Tyr Glu Leu 
            420                 425                 430         


Lys Thr Ile Leu Asn Lys Ala Ala Ser Tyr Leu Pro Phe Leu Thr Gln 
        435                 440                 445             


Cys Gly Lys Asp Ala Ile Ser Asn Gln Asp Lys Leu Leu Ser Ile Met 
    450                 455                 460                 


Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu Arg Lys Asp Asn Ser 
465                 470                 475                 480 


Glu His Ala Trp Leu Glu Arg Lys Ala Gly Lys Ile Tyr Pro Trp Asn 
                485                 490                 495     


Phe Asn Asp Lys Val Asp Leu Asp Lys Ser Glu Glu Ala Phe Ile Arg 
            500                 505                 510         


Arg Met Thr Asn Thr Cys Thr Tyr Tyr Pro Gly Glu Asp Val Leu Pro 
        515                 520                 525             


Leu Asp Ser Leu Ile Tyr Glu Lys Phe Met Ile Leu Asn Glu Ile Asn 
    530                 535                 540                 


Asn Ile Arg Ile Asp Gly Tyr Pro Ile Ser Val Asp Val Lys Gln Gln 
545                 550                 555                 560 


Val Phe Gly Leu Phe Glu Lys Lys Arg Arg Val Thr Val Lys Asp Ile 
                565                 570                 575     


Gln Asn Leu Leu Leu Ser Leu Gly Ala Leu Asp Lys His Gly Lys Leu 
            580                 585                 590         


Thr Gly Ile Asp Thr Thr Ile His Ser Asn Tyr Asn Thr Tyr His His 
        595                 600                 605             


Phe Lys Ser Leu Met Glu Arg Gly Val Leu Thr Arg Asp Asp Val Glu 
    610                 615                 620                 


Arg Ile Val Glu Arg Met Thr Tyr Ser Asp Asp Thr Lys Arg Val Arg 
625                 630                 635                 640 


Leu Trp Leu Asn Asn Asn Tyr Gly Thr Leu Thr Ala Asp Asp Val Lys 
                645                 650                 655     


His Ile Ser Arg Leu Arg Lys His Asp Phe Gly Arg Leu Ser Lys Met 
            660                 665                 670         


Phe Leu Thr Gly Leu Lys Gly Val His Lys Glu Thr Gly Glu Arg Ala 
        675                 680                 685             


Ser Ile Leu Asp Phe Met Trp Asn Thr Asn Asp Asn Leu Met Gln Leu 
    690                 695                 700                 


Leu Ser Glu Cys Tyr Thr Phe Ser Asp Glu Ile Thr Lys Leu Gln Glu 
705                 710                 715                 720 


Ala Tyr Tyr Ala Lys Ala Gln Leu Ser Leu Asn Asp Phe Leu Asp Ser 
                725                 730                 735     


Met Tyr Ile Ser Asn Ala Val Lys Arg Pro Ile Tyr Arg Thr Leu Ala 
            740                 745                 750         


Val Val Asn Asp Ile Arg Lys Ala Cys Gly Thr Ala Pro Lys Arg Ile 
        755                 760                 765             


Phe Ile Glu Met Ala Arg Asp Gly Glu Ser Lys Lys Lys Arg Ser Val 
    770                 775                 780                 


Thr Arg Arg Glu Gln Ile Lys Asn Leu Tyr Arg Ser Ile Arg Lys Asp 
785                 790                 795                 800 


Phe Gln Gln Glu Val Asp Phe Leu Glu Lys Ile Leu Glu Asn Lys Ser 
                805                 810                 815     


Asp Gly Gln Leu Gln Ser Asp Ala Leu Tyr Leu Tyr Phe Ala Gln Leu 
            820                 825                 830         


Gly Arg Asp Met Tyr Thr Gly Asp Pro Ile Lys Leu Glu His Ile Lys 
        835                 840                 845             


Asp Gln Ser Phe Tyr Asn Ile Asp His Ile Tyr Pro Gln Ser Met Val 
    850                 855                 860                 


Lys Asp Asp Ser Leu Asp Asn Lys Val Leu Val Gln Ser Glu Ile Asn 
865                 870                 875                 880 


Gly Glu Lys Ser Ser Arg Tyr Pro Leu Asp Ala Ala Ile Arg Asn Lys 
                885                 890                 895     


Met Lys Pro Leu Trp Asp Ala Tyr Tyr Asn His Gly Leu Ile Ser Leu 
            900                 905                 910         


Lys Lys Tyr Gln Arg Leu Thr Arg Ser Thr Pro Phe Thr Asp Asp Glu 
        915                 920                 925             


Lys Trp Asp Phe Ile Asn Arg Gln Leu Val Glu Thr Arg Gln Ser Thr 
    930                 935                 940                 


Lys Ala Leu Ala Ile Leu Leu Lys Arg Lys Phe Pro Asp Thr Glu Ile 
945                 950                 955                 960 


Val Tyr Ser Lys Ala Gly Leu Ser Ser Asp Phe Arg His Glu Phe Gly 
                965                 970                 975     


Leu Val Lys Ser Arg Asn Ile Asn Asp Leu His His Ala Lys Asp Ala 
            980                 985                 990         


Phe Leu Ala Ile Val Thr Gly Asn  Val Tyr His Glu Arg  Phe Asn Arg 
        995                 1000                 1005             


Arg Trp  Phe Met Val Asn Gln  Pro Tyr Ser Val Lys  Thr Lys Thr 
    1010                 1015                 1020             


Leu Phe  Thr His Ser Ile Lys  Asn Gly Asn Phe Val  Ala Trp Asn 
    1025                 1030                 1035             


Gly Glu  Glu Asp Leu Gly Arg  Ile Val Lys Met Leu  Lys Gln Asn 
    1040                 1045                 1050             


Lys Asn  Thr Ile His Phe Thr  Arg Phe Ser Phe Asp  Arg Lys Glu 
    1055                 1060                 1065             


Gly Leu  Phe Asp Ile Gln Pro  Leu Lys Ala Ser Thr  Gly Leu Val 
    1070                 1075                 1080             


Pro Arg  Lys Ala Gly Leu Asp  Val Val Lys Tyr Gly  Gly Tyr Asp 
    1085                 1090                 1095             


Lys Ser  Thr Ala Ala Tyr Tyr  Leu Leu Val Arg Phe  Thr Leu Glu 
    1100                 1105                 1110             


Asp Lys  Lys Thr Gln His Lys  Leu Met Met Ile Pro  Val Glu Gly 
    1115                 1120                 1125             


Leu Tyr  Lys Ala Arg Ile Asp  His Asp Lys Glu Phe  Leu Thr Asp 
    1130                 1135                 1140             


Tyr Ala  Gln Thr Thr Ile Ser  Glu Ile Leu Gln Lys  Asp Lys Gln 
    1145                 1150                 1155             


Lys Val  Ile Asn Ile Met Phe  Pro Met Gly Thr Arg  His Ile Lys 
    1160                 1165                 1170             


Leu Asn  Ser Met Ile Ser Ile  Asp Gly Phe Tyr Leu  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ser Ser Lys Gly Lys  Ser Val Leu Cys His  Ala Met Val 
    1190                 1195                 1200             


Pro Leu  Ile Val Pro His Lys  Ile Glu Cys Tyr Ile  Lys Ala Met 
    1205                 1210                 1215             


Glu Ser  Phe Ala Arg Lys Phe  Lys Glu Asn Asn Lys  Leu Arg Ile 
    1220                 1225                 1230             


Val Glu  Lys Phe Asp Lys Ile  Thr Val Glu Asp Asn  Leu Asn Leu 
    1235                 1240                 1245             


Tyr Glu  Leu Phe Leu Gln Lys  Leu Gln His Asn Pro  Tyr Asn Lys 
    1250                 1255                 1260             


Phe Phe  Ser Thr Gln Phe Asp  Val Leu Thr Asn Gly  Arg Ser Thr 
    1265                 1270                 1275             


Phe Thr  Lys Leu Ser Pro Glu  Glu Gln Val Gln Thr  Leu Leu Asn 
    1280                 1285                 1290             


Ile Leu  Ser Ile Phe Lys Thr  Cys Arg Ser Ser Gly  Cys Asp Leu 
    1295                 1300                 1305             


Lys Ser  Ile Asn Gly Ser Ala  Gln Ala Ala Arg Ile  Met Ile Ser 
    1310                 1315                 1320             


Ala Asp  Leu Thr Gly Leu Ser  Lys Lys Tyr Ser Asp  Ile Arg Leu 
    1325                 1330                 1335             


Val Glu  Gln Ser Ala Ser Gly  Leu Phe Val Ser Lys  Ser Gln Asn 
    1340                 1345                 1350             


Leu Leu  Glu Tyr Leu 
    1355             


<210> 42
<211> 1138
<212> PRT
<213> Acidothermus cellulolyticus

<400> 42
Met Gly Gly Ser Glu Val Gly Thr Val Pro Val Thr Trp Arg Leu Gly 
1               5                   10                  15      


Val Asp Val Gly Glu Arg Ser Ile Gly Leu Ala Ala Val Ser Tyr Glu 
            20                  25                  30          


Glu Asp Lys Pro Lys Glu Ile Leu Ala Ala Val Ser Trp Ile His Asp 
        35                  40                  45              


Gly Gly Val Gly Asp Glu Arg Ser Gly Ala Ser Arg Leu Ala Leu Arg 
    50                  55                  60                  


Gly Met Ala Arg Arg Ala Arg Arg Leu Arg Arg Phe Arg Arg Ala Arg 
65                  70                  75                  80  


Leu Arg Asp Leu Asp Met Leu Leu Ser Glu Leu Gly Trp Thr Pro Leu 
                85                  90                  95      


Pro Asp Lys Asn Val Ser Pro Val Asp Ala Trp Leu Ala Arg Lys Arg 
            100                 105                 110         


Leu Ala Glu Glu Tyr Val Val Asp Glu Thr Glu Arg Arg Arg Leu Leu 
        115                 120                 125             


Gly Tyr Ala Val Ser His Met Ala Arg His Arg Gly Trp Arg Asn Pro 
    130                 135                 140                 


Trp Thr Thr Ile Lys Asp Leu Lys Asn Leu Pro Gln Pro Ser Asp Ser 
145                 150                 155                 160 


Trp Glu Arg Thr Arg Glu Ser Leu Glu Ala Arg Tyr Ser Val Ser Leu 
                165                 170                 175     


Glu Pro Gly Thr Val Gly Gln Trp Ala Gly Tyr Leu Leu Gln Arg Ala 
            180                 185                 190         


Pro Gly Ile Arg Leu Asn Pro Thr Gln Gln Ser Ala Gly Arg Arg Ala 
        195                 200                 205             


Glu Leu Ser Asn Ala Thr Ala Phe Glu Thr Arg Leu Arg Gln Glu Asp 
    210                 215                 220                 


Val Leu Trp Glu Leu Arg Cys Ile Ala Asp Val Gln Gly Leu Pro Glu 
225                 230                 235                 240 


Asp Val Val Ser Asn Val Ile Asp Ala Val Phe Cys Gln Lys Arg Pro 
                245                 250                 255     


Ser Val Pro Ala Glu Arg Ile Gly Arg Asp Pro Leu Asp Pro Ser Gln 
            260                 265                 270         


Leu Arg Ala Ser Arg Ala Cys Leu Glu Phe Gln Glu Tyr Arg Ile Val 
        275                 280                 285             


Ala Ala Val Ala Asn Leu Arg Ile Arg Asp Gly Ser Gly Ser Arg Pro 
    290                 295                 300                 


Leu Ser Leu Glu Glu Arg Asn Ala Val Ile Glu Ala Leu Leu Ala Gln 
305                 310                 315                 320 


Thr Glu Arg Ser Leu Thr Trp Ser Asp Ile Ala Leu Glu Ile Leu Lys 
                325                 330                 335     


Leu Pro Asn Glu Ser Asp Leu Thr Ser Val Pro Glu Glu Asp Gly Pro 
            340                 345                 350         


Ser Ser Leu Ala Tyr Ser Gln Phe Ala Pro Phe Asp Glu Thr Ser Ala 
        355                 360                 365             


Arg Ile Ala Glu Phe Ile Ala Lys Asn Arg Arg Lys Ile Pro Thr Phe 
    370                 375                 380                 


Ala Gln Trp Trp Gln Glu Gln Asp Arg Thr Ser Arg Ser Asp Leu Val 
385                 390                 395                 400 


Ala Ala Leu Ala Asp Asn Ser Ile Ala Gly Glu Glu Glu Gln Glu Leu 
                405                 410                 415     


Leu Val His Leu Pro Asp Ala Glu Leu Glu Ala Leu Glu Gly Leu Ala 
            420                 425                 430         


Leu Pro Ser Gly Arg Val Ala Tyr Ser Arg Leu Thr Leu Ser Gly Leu 
        435                 440                 445             


Thr Arg Val Met Arg Asp Asp Gly Val Asp Val His Asn Ala Arg Lys 
    450                 455                 460                 


Thr Cys Phe Gly Val Asp Asp Asn Trp Arg Pro Pro Leu Pro Ala Leu 
465                 470                 475                 480 


His Glu Ala Thr Gly His Pro Val Val Asp Arg Asn Leu Ala Ile Leu 
                485                 490                 495     


Arg Lys Phe Leu Ser Ser Ala Thr Met Arg Trp Gly Pro Pro Gln Ser 
            500                 505                 510         


Ile Val Val Glu Leu Ala Arg Gly Ala Ser Glu Ser Arg Glu Arg Gln 
        515                 520                 525             


Ala Glu Glu Glu Ala Ala Arg Arg Ala His Arg Lys Ala Asn Asp Arg 
    530                 535                 540                 


Ile Arg Ala Glu Leu Arg Ala Ser Gly Leu Ser Asp Pro Ser Pro Ala 
545                 550                 555                 560 


Asp Leu Val Arg Ala Arg Leu Leu Glu Leu Tyr Asp Cys His Cys Met 
                565                 570                 575     


Tyr Cys Gly Ala Pro Ile Ser Trp Glu Asn Ser Glu Leu Asp His Ile 
            580                 585                 590         


Val Pro Arg Thr Asp Gly Gly Ser Asn Arg His Glu Asn Leu Ala Ile 
        595                 600                 605             


Thr Cys Gly Ala Cys Asn Lys Glu Lys Gly Arg Arg Pro Phe Ala Ser 
    610                 615                 620                 


Trp Ala Glu Thr Ser Asn Arg Val Gln Leu Arg Asp Val Ile Asp Arg 
625                 630                 635                 640 


Val Gln Lys Leu Lys Tyr Ser Gly Asn Met Tyr Trp Thr Arg Asp Glu 
                645                 650                 655     


Phe Ser Arg Tyr Lys Lys Ser Val Val Ala Arg Leu Lys Arg Arg Thr 
            660                 665                 670         


Ser Asp Pro Glu Val Ile Gln Ser Ile Glu Ser Thr Gly Tyr Ala Ala 
        675                 680                 685             


Val Ala Leu Arg Asp Arg Leu Leu Ser Tyr Gly Glu Lys Asn Gly Val 
    690                 695                 700                 


Ala Gln Val Ala Val Phe Arg Gly Gly Val Thr Ala Glu Ala Arg Arg 
705                 710                 715                 720 


Trp Leu Asp Ile Ser Ile Glu Arg Leu Phe Ser Arg Val Ala Ile Phe 
                725                 730                 735     


Ala Gln Ser Thr Ser Thr Lys Arg Leu Asp Arg Arg His His Ala Val 
            740                 745                 750         


Asp Ala Val Val Leu Thr Thr Leu Thr Pro Gly Val Ala Lys Thr Leu 
        755                 760                 765             


Ala Asp Ala Arg Ser Arg Arg Val Ser Ala Glu Phe Trp Arg Arg Pro 
    770                 775                 780                 


Ser Asp Val Asn Arg His Ser Thr Glu Glu Pro Gln Ser Pro Ala Tyr 
785                 790                 795                 800 


Arg Gln Trp Lys Glu Ser Cys Ser Gly Leu Gly Asp Leu Leu Ile Ser 
                805                 810                 815     


Thr Ala Ala Arg Asp Ser Ile Ala Val Ala Ala Pro Leu Arg Leu Arg 
            820                 825                 830         


Pro Thr Gly Ala Leu His Glu Glu Thr Leu Arg Ala Phe Ser Glu His 
        835                 840                 845             


Thr Val Gly Ala Ala Trp Lys Gly Ala Glu Leu Arg Arg Ile Val Glu 
    850                 855                 860                 


Pro Glu Val Tyr Ala Ala Phe Leu Ala Leu Thr Asp Pro Gly Gly Arg 
865                 870                 875                 880 


Phe Leu Lys Val Ser Pro Ser Glu Asp Val Leu Pro Ala Asp Glu Asn 
                885                 890                 895     


Arg His Ile Val Leu Ser Asp Arg Val Leu Gly Pro Arg Asp Arg Val 
            900                 905                 910         


Lys Leu Phe Pro Asp Asp Arg Gly Ser Ile Arg Val Arg Gly Gly Ala 
        915                 920                 925             


Ala Tyr Ile Ala Ser Phe His His Ala Arg Val Phe Arg Trp Gly Ser 
    930                 935                 940                 


Ser His Ser Pro Ser Phe Ala Leu Leu Arg Val Ser Leu Ala Asp Leu 
945                 950                 955                 960 


Ala Val Ala Gly Leu Leu Arg Asp Gly Val Asp Val Phe Thr Ala Glu 
                965                 970                 975     


Leu Pro Pro Trp Thr Pro Ala Trp Arg Tyr Ala Ser Ile Ala Leu Val 
            980                 985                 990         


Lys Ala Val Glu Ser Gly Asp Ala  Lys Gln Val Gly Trp  Leu Val Pro 
        995                 1000                 1005             


Gly Asp  Glu Leu Asp Phe Gly  Pro Glu Gly Val Thr  Thr Ala Ala 
    1010                 1015                 1020             


Gly Asp  Leu Ser Met Phe Leu  Lys Tyr Phe Pro Glu  Arg His Trp 
    1025                 1030                 1035             


Val Val  Thr Gly Phe Glu Asp  Asp Lys Arg Ile Asn  Leu Lys Pro 
    1040                 1045                 1050             


Ala Phe  Leu Ser Ala Glu Gln  Ala Glu Val Leu Arg  Thr Glu Arg 
    1055                 1060                 1065             


Ser Asp  Arg Pro Asp Thr Leu  Thr Glu Ala Gly Glu  Ile Leu Ala 
    1070                 1075                 1080             


Gln Phe  Phe Pro Arg Cys Trp  Arg Ala Thr Val Ala  Lys Val Leu 
    1085                 1090                 1095             


Cys His  Pro Gly Leu Thr Val  Ile Arg Arg Thr Ala  Leu Gly Gln 
    1100                 1105                 1110             


Pro Arg  Trp Arg Arg Gly His  Leu Pro Tyr Ser Trp  Arg Pro Trp 
    1115                 1120                 1125             


Ser Ala  Asp Pro Trp Ser Gly  Gly Thr Pro 
    1130                 1135             


<210> 43
<211> 1045
<212> PRT
<213> Acidovorax avenae

<400> 43
Met Gln Lys Glu Lys Pro Leu Ala Tyr Arg Leu Ala Leu Asp Leu Gly 
1               5                   10                  15      


Ser Thr Ser Leu Gly Trp Ala Val Leu Arg Leu Ser Ala Pro Gly Glu 
            20                  25                  30          


Pro Ser Ala Val Ile Arg Ala Gly Ser Arg Ile Phe Ser Asp Gly Arg 
        35                  40                  45              


Asn Pro Lys Asp Gly Ser Ser Leu Ala Val Thr Arg Arg Ala Ala Arg 
    50                  55                  60                  


Ala Met Arg Arg Arg Arg Asp Arg Leu Leu Lys Arg Lys Ala Arg Met 
65                  70                  75                  80  


Leu Ala Ala Leu Glu Arg His Gly Phe Phe Pro Gln Asp Glu Ala Ala 
                85                  90                  95      


Arg Lys Ala Leu Glu Lys Leu Asn Pro Tyr Gly Leu Arg Ala Arg Gly 
            100                 105                 110         


Leu Glu Ser Ala Leu Lys Pro Glu Glu Phe Gly Arg Ala Leu Phe His 
        115                 120                 125             


Leu Asn Gln Arg Arg Gly Phe Gln Ser Asn Arg Lys Thr Asp Arg Lys 
    130                 135                 140                 


Asp Ser Asp Ser Gly Ala Leu Lys Gln Ala Ile Gly Thr Leu Arg Ala 
145                 150                 155                 160 


Gln Met His Glu Ser Gly Cys Arg Thr Val Gly Glu Trp Phe Trp Lys 
                165                 170                 175     


Val Arg Met Glu Arg Lys Pro Glu Gly Val Lys Gly Gln Gly Val Arg 
            180                 185                 190         


Ala Arg Tyr Arg Glu Thr Pro Phe Thr Thr Asp Glu Gly Lys Lys Arg 
        195                 200                 205             


Ile Asp Lys Arg Tyr Asp Leu Tyr Val Asp Arg Ala Met Val Ala Gln 
    210                 215                 220                 


Glu Phe Asp Ala Leu Trp Ala Ala Gln Ala Thr Phe Ala Pro Ala Leu 
225                 230                 235                 240 


Phe Asn Glu Ala Ala Arg Ala Glu Leu Arg Asp Ile Leu Leu His Gln 
                245                 250                 255     


Arg Lys Leu Arg Pro Val Gln Pro Gly Arg Cys Thr Leu Val Pro Glu 
            260                 265                 270         


Glu Pro Arg Ala Leu Leu Ala Leu Pro Ser Thr Gln Arg Phe Arg Ile 
        275                 280                 285             


Tyr Gln Glu Val Asn His Leu Arg Val Leu His Asp Glu Leu Arg Glu 
    290                 295                 300                 


Glu Ala Leu Thr Leu Ala Gln Arg Asp Gln Ile Val Ala Leu Leu Glu 
305                 310                 315                 320 


Arg Gln Ala Lys Val Thr Phe Thr Ala Met Arg Lys Ala Leu Gly Phe 
                325                 330                 335     


Ser Ala Leu Phe Asn Leu Glu Asp Ala Lys Arg Asp Gly Leu Lys Gly 
            340                 345                 350         


Asn Ala Thr Thr Ala Ala Leu Gly Lys Lys Asp Leu Phe Gly Pro Leu 
        355                 360                 365             


Trp Ala Gly Phe Asp Thr Ala Leu Gln Asp Glu Ile Val Thr Gln Leu 
    370                 375                 380                 


Met Thr Glu Glu Ser Glu Pro Arg Leu Ile Ala Trp Leu Gln Glu His 
385                 390                 395                 400 


Thr Gly Val Asp Glu Ala Arg Ala Gln Ala Ile Ala Asn Ala Gly Leu 
                405                 410                 415     


Pro Glu Gly Tyr Gly Ser Leu Gly Arg Thr Ala Leu Ala Arg Ile Val 
            420                 425                 430         


Pro Glu Leu Gln Arg Asp Val Ile Thr Tyr Asp Lys Ala Val Gln Ala 
        435                 440                 445             


Ala Gly Phe Ala His His Ser Asp Leu Gly Phe Ser Phe Glu His Asp 
    450                 455                 460                 


Ala Asp Glu Val Glu Arg Ile Gly Glu Arg Thr Ile Ala Ser Thr Gly 
465                 470                 475                 480 


Glu Ile Lys Pro Val Phe Ala Phe Lys Gln Leu Pro Tyr Tyr Gly Arg 
                485                 490                 495     


Ala Leu Gln Arg His Val Ala Phe Ala Lys Glu Asn Pro Arg Asn Asp 
            500                 505                 510         


Glu Glu Arg Tyr Gly Lys Ile Ala Asn Pro Thr Val His Ile Gly Leu 
        515                 520                 525             


Asn Gln Val Arg Val Val Val Asn Ala Leu Met Cys Arg Tyr Gly Arg 
    530                 535                 540                 


Pro Thr Glu Val Val Ile Glu Leu Ala Arg Asp Leu Lys Gln Ser Arg 
545                 550                 555                 560 


Glu Gln Lys Leu Glu Ala Gln Gln Arg Gln Ala Asp Asn Gln Lys Arg 
                565                 570                 575     


Asn Ala Arg Ile Arg Arg Ser Ile Ala Glu Val Leu Gly Ile Ser Glu 
            580                 585                 590         


Glu Arg Val Arg Thr Leu Asp Ile Gln Lys Trp Ile Leu Trp Glu Glu 
        595                 600                 605             


Leu Ser His Asp Ala Ala Asp Arg Arg Cys Pro Tyr Ser Gly Val Gln 
    610                 615                 620                 


Ile Ser Ala Ser Met Leu Leu Gly Glu Arg Val Glu Ile Glu His Ile 
625                 630                 635                 640 


Leu Pro Phe Ser Met Thr Leu Asp Asp Ser Leu Asn Asn Arg Thr Val 
                645                 650                 655     


Ala Leu Arg Glu Ala Asn Arg Ile Lys Arg Asn Arg Thr Pro Trp Asp 
            660                 665                 670         


Ala Arg Thr Asp Phe Glu Ala His Gly Trp Ser Tyr Asp Gly Ile Leu 
        675                 680                 685             


Gln Arg Ala Glu Arg Met Pro Gln Arg Lys Arg His Arg Phe Ala Pro 
    690                 695                 700                 


Asp Gly Tyr Glu Arg Trp Leu Gly Glu Asp Lys Asp Phe Leu Ala Arg 
705                 710                 715                 720 


Ala Leu Asn Asp Thr Arg Tyr Leu Ser Arg Val Ala Ala Glu Tyr Leu 
                725                 730                 735     


Arg Leu Val Cys Pro Gly Ser Ala Thr Arg Val Ile Pro Gly Gln Met 
            740                 745                 750         


Thr Ala Leu Leu Arg Gly Lys Phe Gly Leu Asn Asp Val Leu Gly Leu 
        755                 760                 765             


Asp Gly Glu Lys Asn Arg Asn Asp His Arg His His Ala Val Asp Ala 
    770                 775                 780                 


Cys Val Ile Gly Val Thr Asp Gln Arg Met Met Gln Arg Phe Ala Gln 
785                 790                 795                 800 


Ala Asn Ala Gln Ala Arg Glu Asp Gly Leu Thr Arg Leu Val Glu Asp 
                805                 810                 815     


Met Pro Leu Pro Trp Pro Thr Tyr Arg Ala His Val Glu Arg Ala Val 
            820                 825                 830         


Arg His Ile Trp Val Ser His Lys Pro Asp His Gly Phe Glu Gly Ala 
        835                 840                 845             


Met Met Glu Glu Thr Ser Tyr Gly Ile Leu Arg Asp Gly Thr Ile Lys 
    850                 855                 860                 


Gln Arg Arg Lys Ala Asp Gly Ser Ala Gly Arg Glu Ile Ser Arg Leu 
865                 870                 875                 880 


Ile Arg Ile Thr Glu Pro Ser Gln Pro Gln Arg His Gly Val Asp Ala 
                885                 890                 895     


Glu Gly Arg Pro Leu Pro Tyr Lys Gly Tyr Val Gly Gly Ser Asn Tyr 
            900                 905                 910         


Cys Leu Glu Ile Thr Val Asn Asp Lys Gly Lys Trp Glu Gly Gln Val 
        915                 920                 925             


Ile Ser Thr Phe Asp Ala Tyr Arg Ile Val Arg Glu Gly Gly Leu Arg 
    930                 935                 940                 


Gln Leu Arg His Ser Thr Gln Gly Gln Asn Gly Gln Ala Leu Ala Met 
945                 950                 955                 960 


Arg Leu Val Ile Gly Asp Ser Val Arg Leu Glu Val Asp Glu Gln Glu 
                965                 970                 975     


Arg Val Met Arg Ile Val Lys Ile Asn Gly Asn Asn Gly Gln Val Phe 
            980                 985                 990         


Met Ala Pro Val His Glu Ala Asn  Val Asp Ala Arg Asn  Ser Asp Lys 
        995                 1000                 1005             


Asn Glu  Ala Phe Ala Tyr Thr  Ser Lys Ile Ala Gly  Ser Phe Gln 
    1010                 1015                 1020             


Lys Thr  Lys Ala Arg Gln Val  Thr Ile Ser Pro Ile  Gly Glu Leu 
    1025                 1030                 1035             


Arg Asp  Pro Gly Phe Lys Gly  
    1040                 1045 


<210> 44
<211> 1131
<212> PRT
<213> Acidovorax ebreus

<400> 44
Met Ala Gln His Val Phe Gly Leu Asp Ile Gly Ile Ala Ser Val Gly 
1               5                   10                  15      


Trp Ala Ile Leu Gly Glu Gln Arg Ile Ile Asp Leu Gly Val Arg Cys 
            20                  25                  30          


Phe Asp Lys Ala Glu Thr Ala Lys Glu Gly Asp Pro Leu Asn Leu Thr 
        35                  40                  45              


Arg Arg Gln Ala Arg Leu Leu Arg Arg Arg Leu Tyr Arg Arg Ala Trp 
    50                  55                  60                  


Arg Leu Thr Gln Leu Ser Arg Leu Leu Lys Arg Lys Gly Leu Ile Ala 
65                  70                  75                  80  


Asp Ala Lys Leu Phe Ala Lys Ala Pro Ser Tyr Gly Asp Ser Ala Trp 
                85                  90                  95      


Glu Leu Arg Arg Gln Gly Leu Asp Arg Leu Leu Thr Pro Leu Glu Trp 
            100                 105                 110         


Ala Arg Val Ile Tyr His Gln Cys Lys His Arg Gly Phe His Trp Thr 
        115                 120                 125             


Ser Lys Ala Glu Glu Ala Lys Ala Asp Ser Asp Ala Glu Gly Gly Arg 
    130                 135                 140                 


Val Lys Gln Gly Leu Ala His Thr Lys Ala Leu Met Gln Ala Lys Asn 
145                 150                 155                 160 


Tyr Arg Ser Ala Ala Glu Met Val Leu Ala Glu Phe Pro Asp Ala Gln 
                165                 170                 175     


Arg Asn Lys Arg Gly Gln Tyr Asp Lys Ala Leu Ser Arg Val Leu Leu 
            180                 185                 190         


Gly Glu Glu Leu Ala Leu Leu Phe Ala Thr Gln Arg Arg Leu Gly Asn 
        195                 200                 205             


Pro His Ala Ser Asp Phe Phe Glu Lys Leu Ile Leu Gly Asp Gly Asp 
    210                 215                 220                 


Arg Lys Ser Gly Leu Phe Trp Gln Gln Lys Pro Ala Leu Ser Gly Ala 
225                 230                 235                 240 


Asp Leu Leu Lys Met Leu Gly Lys Cys Thr Phe Glu Lys Gly Glu Tyr 
                245                 250                 255     


Arg Ala Pro Lys Ala Ser Phe Ser Val Glu Arg His Val Trp Leu Thr 
            260                 265                 270         


Arg Leu Asn Asn Leu Arg Ile Val Val Asp Gly Arg Ser Arg Pro Leu 
        275                 280                 285             


Asn Glu Ala Glu Arg Gln Ala Ala Leu Leu Leu Pro Tyr Gln Thr Glu 
    290                 295                 300                 


Thr Ser Lys Tyr Lys Thr Leu Lys Asn Ala Phe Ile Lys Ala Gly Leu 
305                 310                 315                 320 


Trp Gly Asp Gly Val Arg Phe Gly Gly Leu Ala Tyr Pro Ser Gln Ala 
                325                 330                 335     


Gln Ile Asp Ala Glu Lys Thr Lys Asp Pro Glu Asp Gln Phe Leu Val 
            340                 345                 350         


Lys Leu Pro Ala Trp His Glu Leu Arg Lys Ala Phe Lys Ala Ala Gly 
        355                 360                 365             


His Glu Ala Leu Trp Gln Gln Ile Ser Thr Pro Ala Leu Asp Gly Asp 
    370                 375                 380                 


Pro Thr Leu Leu Asp Gln Ile Ala Thr Val Leu Ser Val Tyr Lys Asp 
385                 390                 395                 400 


Gly Ala Glu Val Val Gln Gln Leu Arg Gln Leu Ala Leu Pro Glu Pro 
                405                 410                 415     


Ala Ala Ser Ile Ala Val Leu Glu Lys Ile Ser Phe Asp Lys Phe Ser 
            420                 425                 430         


Ser Leu Ser Leu Lys Ala Leu Arg Arg Ile Val Pro Leu Met Gln Ser 
        435                 440                 445             


Gly Leu Arg Tyr Asp Glu Ala Val Ala Gln Ile Pro Glu Tyr Gly His 
    450                 455                 460                 


His Ser Gln Arg Ile Glu Pro Gly Ala Ala Lys His Leu Tyr Leu Pro 
465                 470                 475                 480 


Pro Phe Tyr Glu Ala Gln Arg Lys Tyr Ala Gly Lys Gly Asp His Ile 
                485                 490                 495     


Gly Ser Met Gln Phe Arg Asp Asp Ala Asp Ile Pro Arg Asn Pro Val 
            500                 505                 510         


Val Leu Arg Ala Leu Asn Gln Ala Arg Lys Val Val Asn Ala Leu Ile 
        515                 520                 525             


Arg Glu Tyr Gly Ser Pro Ile Ala Val Asn Ile Glu Met Ala Arg Asp 
    530                 535                 540                 


Leu Ser Arg Pro Leu Asp Glu Arg Asn Lys Val Lys Arg Ala Gln Glu 
545                 550                 555                 560 


Glu Phe Arg Asp Arg Asn Asp Arg Ala Arg Ser Glu Phe Glu Arg Asp 
                565                 570                 575     


Phe Gly Tyr Lys Pro Lys Ala Ala Ala Phe Glu Lys Trp Met Leu Tyr 
            580                 585                 590         


Arg Glu Gln Leu Gly Gln Cys Ala Tyr Ser Gln Gln Pro Leu Asp Ile 
        595                 600                 605             


Gln Arg Val Leu Asp Asp His Asn Tyr Ala Gln Val Asp His Ala Leu 
    610                 615                 620                 


Pro Tyr Ser Arg Ser Tyr Asp Asp Ser Lys Asn Asn Lys Val Leu Val 
625                 630                 635                 640 


Leu Thr His Glu Asn Gln Asn Lys Gly Asn Arg Thr Ala Phe Glu Tyr 
                645                 650                 655     


Leu Thr Ser Phe Pro Asp Gly Glu Asp Gly Glu Arg Trp Arg Thr Phe 
            660                 665                 670         


Val Ala Trp Val Gln Gly Asn Lys Ala Tyr Arg Met Ala Lys Arg Asn 
        675                 680                 685             


Arg Leu Leu Arg Lys Asn Tyr Gly Val Asp Glu Ser Lys Gly Phe Ile 
    690                 695                 700                 


Asp Arg Asn Leu Asn Asp Thr Arg Tyr Ile Cys Lys Phe Phe Lys Asn 
705                 710                 715                 720 


Tyr Val Glu Glu His Leu Gln Leu Ala Ala Arg Ala Asp Gly Asp Thr 
                725                 730                 735     


Ala Arg Arg Cys Val Val Val Asn Gly Gln Leu Thr Ala Phe Leu Arg 
            740                 745                 750         


Ala Arg Trp Gly Leu Thr Lys Val Arg Gly Asp Ser Asp Arg His His 
        755                 760                 765             


Ala Leu Asp Ala Ala Val Val Ala Ala Cys Thr His Gly Met Val Lys 
    770                 775                 780                 


Ala Leu Ala Asp Tyr Ser Arg Arg Lys Glu Ile Ser Phe Leu Gln Glu 
785                 790                 795                 800 


Gly Phe Pro Asp Pro Glu Thr Gly Glu Ile Leu Asn Pro Ala Ala Phe 
                805                 810                 815     


Asp Arg Ala Arg Gln His Phe Pro Glu Pro Trp Thr His Phe Ala His 
            820                 825                 830         


Glu Leu Lys Ala Arg Leu Phe Thr Asp Asp Leu Ala Ala Leu Arg Glu 
        835                 840                 845             


Asp Met Gln Arg Leu Gly Ser Tyr Thr Thr Glu Asp Leu Gly Arg Leu 
    850                 855                 860                 


Arg Thr Leu Phe Val Ser Arg Ala Pro Gln Arg Arg Ser Gly Gly Ala 
865                 870                 875                 880 


Val His Lys Glu Thr Ile Tyr Ala Gln Pro Glu Ser Leu Lys Gln Gln 
                885                 890                 895     


Gly Gly Val Ile Glu Lys Ile Leu Leu Thr Ser Leu Lys Leu Gln Asp 
            900                 905                 910         


Phe Asp Lys Leu Leu Asn Pro Glu Ser Asn Asp His Phe Val Glu Pro 
        915                 920                 925             


His Arg Asn Glu Arg Leu Tyr Ala Ala Ile Arg Gln Arg Leu Glu Gln 
    930                 935                 940                 


Phe Gly Gly Arg Ala Asp Lys Ala Phe Gly Pro Asp Asn Leu Phe His 
945                 950                 955                 960 


Lys Pro Asp Lys Asn Asn Gln Pro Thr Gly Pro Val Val Arg Ser Ile 
                965                 970                 975     


Lys Leu Val Arg Gly Lys Gln Thr Gly Ile Pro Ile Arg Gly Gly Leu 
            980                 985                 990         


Ala Lys Asn Asp Ser Met Leu Arg  Val Asp Ile Phe Thr  Lys Ala Gly 
        995                 1000                 1005             


Lys Phe  His Leu Val Pro Val  Tyr Val His His Arg  Val Thr Gly 
    1010                 1015                 1020             


Leu Pro  Asn Arg Ala Ile Val  Ala Phe Lys Asp Glu  Asp Glu Trp 
    1025                 1030                 1035             


Thr Leu  Ile Asp Glu Ser Phe  Ala Phe Leu Phe Ser  Val Tyr Pro 
    1040                 1045                 1050             


Asn Asp  Tyr Val Lys Val Thr  Leu Lys Lys Glu Gln  Gln Ser Gly 
    1055                 1060                 1065             


Tyr Tyr  Ser Gly Ala Asp Arg  Ser Thr Gly Ala Met  Asn Leu Trp 
    1070                 1075                 1080             


Ala His  Asp Arg Ala Ala Ser  Val Gly Lys Asp Gly  Leu Ile Arg 
    1085                 1090                 1095             


Gly Ile  Gly Val Lys Thr Ala  Leu Ser Val Glu Lys  Phe Asn Val 
    1100                 1105                 1110             


Asp Val  Leu Gly Arg Ile Tyr  Leu Ala Pro Pro Glu  Thr Arg Ser 
    1115                 1120                 1125             


Gly Leu  Ala 
    1130     


<210> 45
<211> 1056
<212> PRT
<213> Actinobacillus minor


<220>
<223> Actinobacillus minor NM305

<400> 45
Met Lys Ala Leu Asn Tyr Ile Leu Gly Leu Asp Leu Gly Ile Ala Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Val Glu Ile Asp Gln Asn Glu Leu Pro Ile Arg 
            20                  25                  30          


Leu Ile Asp Leu Gly Val Arg Thr Phe Glu Arg Ala Glu Val Pro Lys 
        35                  40                  45              


Thr Gly Asp Ser Leu Ala Leu Ala Arg Arg Leu Ala Arg Ser Ser Arg 
    50                  55                  60                  


Arg Leu Val Arg Arg Arg Ala Val Arg Leu Leu Lys Ala Lys Arg Leu 
65                  70                  75                  80  


Leu Lys Gln Glu Gly Ile Leu Gln Ala Asp Asp Phe His Ser Ser His 
                85                  90                  95      


Leu Lys Pro Leu Pro Asn Asn Pro Trp Glu Leu Arg Val Lys Gly Leu 
            100                 105                 110         


Asn His Leu Leu Asp Arg Lys Glu Trp Ala Ala Val Leu Leu His Leu 
        115                 120                 125             


Leu Lys His Arg Gly Tyr Leu Ser Gln Arg Lys Asn Glu Ser Lys Thr 
    130                 135                 140                 


Asp Asn Lys Glu Leu Gly Ala Leu Leu Lys Gly Val Ser Glu Asn Arg 
145                 150                 155                 160 


Gln Leu Leu Gln Ala Gln Ala Phe Ser Thr Pro Ala Glu Ile Ala Ile 
                165                 170                 175     


Lys Lys Phe Gln Gln Glu Glu Gly His Ile Arg Asn Gln Arg Gly Ala 
            180                 185                 190         


Tyr Ser His Thr Phe Asp Arg Asn Asp Leu Leu Ala Glu Leu Arg Leu 
        195                 200                 205             


Leu Phe Gln Lys Gln Arg Glu Phe Asn Asn Pro Tyr Thr Ser Gln Ser 
    210                 215                 220                 


Leu Glu Gln Ala Ile Ala Glu Leu Leu Met Trp Gln Lys Pro Ala Leu 
225                 230                 235                 240 


Ser Gly Glu Ala Ile Leu Lys Met Leu Gly Lys Cys Thr Phe Glu Pro 
                245                 250                 255     


Ser Glu Tyr Lys Ala Pro Lys Asn Ser Tyr Ser Ala Glu Tyr Phe Val 
            260                 265                 270         


Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile Leu Glu Asn Gly Ala Asp 
        275                 280                 285             


Arg Gly Leu Thr Ala Glu Glu Arg Gln Leu Leu Ile Asn Gln Pro Phe 
    290                 295                 300                 


Glu Lys Ala Lys Phe Thr Tyr Ala Gln Ala Arg Lys Leu Leu Glu Leu 
305                 310                 315                 320 


Ser Asp Leu Ala Ile Phe Lys Gly Val Arg Tyr Gly Lys Asp Asn Ala 
                325                 330                 335     


Glu Ser Ala Thr Leu Met Glu Met Lys Ala Trp His Ala Ile Arg Lys 
            340                 345                 350         


Ala Leu Glu Ser Asn Gly Leu Lys Thr Glu Trp Asn Gly Leu Lys Thr 
        355                 360                 365             


Lys Pro Glu Leu Leu Asp Lys Ile Gly Thr Ala Phe Ser Ile Tyr Lys 
    370                 375                 380                 


Thr Asp Glu Asp Ile Ser Gln Tyr Leu Asn Gly Glu Leu Ser Pro Ala 
385                 390                 395                 400 


Val Leu Asn Ala Leu Leu Glu Asn Leu Ser Phe Asp Lys Phe Ile Arg 
                405                 410                 415     


Leu Ser Leu Gln Ser Leu Ala Lys Ile Leu Pro Leu Met Glu Gln Gly 
            420                 425                 430         


Leu Arg Tyr Asp Glu Ala Cys Lys Gln Val Tyr Gly Asp His Tyr Gly 
        435                 440                 445             


Lys Lys Glu Gln Leu Glu Leu Arg Phe Leu Pro Lys Ile Pro Val Glu 
    450                 455                 460                 


Asp Ile Arg Asn Pro Val Val Leu Arg Thr Leu Ser Gln Ala Arg Lys 
465                 470                 475                 480 


Val Ile Asn Gly Val Val Arg Leu Tyr Gly Ser Pro Ala Arg Ile His 
                485                 490                 495     


Ile Glu Thr Gly Arg Glu Val Gly Lys Ser Phe Ser Glu Arg Arg Asp 
            500                 505                 510         


Ile Ser Lys Arg Gln Glu Glu Asn Arg Asn Glu Arg Gln Arg Ala Val 
        515                 520                 525             


Glu Lys Phe Lys Glu Phe Phe Pro His Phe Val Gly Glu Pro Lys Ala 
    530                 535                 540                 


Lys Asp Ile Leu Lys Met Arg Leu Tyr Glu Gln Gln His Gly Lys Cys 
545                 550                 555                 560 


Leu Tyr Ser Gly Lys Glu Leu Asp Leu Asn Arg Leu Leu Glu Lys Gly 
                565                 570                 575     


Tyr Val Glu Ile Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp 
            580                 585                 590         


Ser Phe Asn Asn Lys Val Leu Val Leu Ala Ser Glu Asn Gln Asn Lys 
        595                 600                 605             


Gly Asn Gln Thr Pro Tyr Glu Trp Leu Asn Gly Lys Glu Asn Ala Glu 
    610                 615                 620                 


Arg Trp Lys Leu Phe Gln Ala Leu Val Asn Gly Ser Arg Phe Pro Tyr 
625                 630                 635                 640 


Ser Lys Lys Gln Arg Ile Leu Thr Lys Tyr Leu Asp Glu Asp Gly Phe 
                645                 650                 655     


Arg Glu Arg Asn Leu Asn Asp Thr Arg Tyr Val Ala Arg Phe Leu Cys 
            660                 665                 670         


Asn Phe Ile Glu Asp Asn Met Gln Leu Val Gly Gln Gly Lys Lys Arg 
        675                 680                 685             


Val Phe Ala Ser Asn Gly Gln Ile Thr Ala Leu Leu Arg Arg Ser Trp 
    690                 695                 700                 


Gly Ile Gln Lys Val Arg Glu Asp Asn Asp Arg His His Ala Val Asp 
705                 710                 715                 720 


Ala Val Val Val Ala Cys Ser Thr Arg Ala Leu Gln Lys Lys Ile Thr 
                725                 730                 735     


Asp Tyr Val Arg Tyr Lys Glu Met Asn Val Phe Thr Gly Glu Lys Ile 
            740                 745                 750         


Asp Gln Glu Thr Gly Glu Ile Ile Lys Phe His Phe Pro Glu Pro Trp 
        755                 760                 765             


Lys Phe Phe Arg Gln Glu Val Glu Ile Arg Val Phe Ser Glu Thr Pro 
    770                 775                 780                 


Ala Glu Asp Val Val Ile Ala Leu Pro Asp Arg Pro Gln Ala Asn His 
785                 790                 795                 800 


Glu Phe Ile Gln Pro Leu Phe Val Ser Arg Ala Pro Thr Arg Lys Met 
                805                 810                 815     


Thr Gly Gln Gly His Met Glu Thr Ile Lys Ser Ala Lys Arg Leu Ala 
            820                 825                 830         


Glu Gly Leu Ser Val Ser Arg Val Pro Leu Thr Gln Leu Lys Leu Lys 
        835                 840                 845             


Asp Leu Glu Asn Met Val Asn Arg Glu Arg Glu Lys Ala Leu Tyr Glu 
    850                 855                 860                 


Ala Leu Lys Val Arg Leu Glu Lys Phe Asn Asn Asp Pro Ala Lys Ala 
865                 870                 875                 880 


Phe Ala Asp Pro Phe Tyr Lys Lys Gly Gly Gln Gln Val Lys Ala Val 
                885                 890                 895     


Arg Val Glu Gln Val Gln Lys Ser Gly Val Leu Val Arg Gln Glu Asn 
            900                 905                 910         


Gly Val Ala Asp Asn Ala Ser Met Val Arg Val Asp Val Phe Ile Lys 
        915                 920                 925             


Gly Gly Lys Tyr Phe Leu Val Pro Ile Tyr Thr Trp Gln Val Ala Lys 
    930                 935                 940                 


Gly Ile Leu Pro Asn Arg Ala Ala Thr Gln Gly Lys Glu Glu Glu Tyr 
945                 950                 955                 960 


Trp Asp Ile Met Asp Glu Thr Ala Ile Phe Gln Phe Ser Leu Tyr Gln 
                965                 970                 975     


Asn Asp Leu Ile Lys Leu Val Thr Lys Lys Lys Thr Ile Phe Gly Tyr 
            980                 985                 990         


Phe Asn Gly Leu Asn Arg Ala Thr  Ser Asn Ile Asn Ile  Lys Glu His 
        995                 1000                 1005             


Asp Leu  Asp Lys Ser Lys Gly  Lys Asp Gly Ile Tyr  Leu Glu Val 
    1010                 1015                 1020             


Gly Val  Lys Leu Ala Leu Ser  Leu Glu Lys Tyr Gln  Val Asp Glu 
    1025                 1030                 1035             


Leu Gly  Lys Asn Ile Gln Pro  Cys Arg Ser Met Lys  Lys Arg Pro 
    1040                 1045                 1050             


Pro Val  Arg 
    1055     


<210> 46
<211> 1054
<212> PRT
<213> Actinobacillus pleuropneumoniae


<220>
<223> Actinobacillus pleuropneumoniae serovar 10 str. D13039

<400> 46
Met Lys Leu Thr Pro Leu Asn Tyr Ile Leu Gly Leu Asp Leu Gly Ile 
1               5                   10                  15      


Ala Ser Val Gly Trp Ala Val Val Glu Ile Asp Glu Gln Glu Asn Pro 
            20                  25                  30          


Leu Gly Leu Ile Asp Val Gly Val Arg Thr Phe Asp Arg Ala Glu Val 
        35                  40                  45              


Ala Lys Thr Gly Glu Ser Leu Ala Leu Ala Arg Arg Leu Ala Arg Ser 
    50                  55                  60                  


Ser Arg Arg Leu Val Lys Arg Arg Ala Asp Arg Ile Lys Lys Val Lys 
65                  70                  75                  80  


Arg Leu Leu Lys Ser Glu Asn Ile Leu Leu Ser Ala Asp Glu Gln Leu 
                85                  90                  95      


Pro Asn Asp Val Trp Gln Leu Arg Val Lys Gly Leu Asp Gln Lys Leu 
            100                 105                 110         


Glu Arg Gln Glu Trp Ala Ala Val Leu Leu His Leu Leu Lys His Arg 
        115                 120                 125             


Gly Tyr Leu Ser Gln Arg Lys Asn Glu Ser Lys Ser Glu Asn Lys Glu 
    130                 135                 140                 


Leu Gly Ala Leu Arg Ser Gly Val Ala Ala Asn His Gln Ile Leu Gln 
145                 150                 155                 160 


Ser Ala Glu Tyr Arg Thr Pro Ala Glu Ile Ala Val Lys Lys Phe His 
                165                 170                 175     


Val Glu Glu Gly His Ile Arg Asn Gln Arg Gly Ala Tyr Thr His Thr 
            180                 185                 190         


Phe Ser Arg Leu Asp Leu Leu Ala Glu Ile Glu Leu Leu Phe Thr Arg 
        195                 200                 205             


Gln Thr Glu Leu Gly Asn Pro His Thr Ser Ala Lys Leu Leu Glu Asn 
    210                 215                 220                 


Leu Thr Ala Leu Leu Met Trp Gln Lys Pro Ala Leu Ala Gly Glu Ala 
225                 230                 235                 240 


Ile Leu Lys Met Leu Gly Lys Cys Thr Phe Glu Pro Thr Glu Tyr Lys 
                245                 250                 255     


Ala Ala Lys Asn Ser Tyr Ser Ala Glu Arg Phe Val Trp Leu Thr Lys 
            260                 265                 270         


Leu Asn Asn Leu Arg Ile Leu Glu Gln Gly Ala Glu Arg Ala Leu Thr 
        275                 280                 285             


Asp Asn Glu Arg Phe Ala Leu Leu Asp Gln Pro Tyr Glu Lys Ala Lys 
    290                 295                 300                 


Phe Thr Tyr Ala Gln Ala Arg Thr Met Leu Ala Leu Pro Asp Glu Ala 
305                 310                 315                 320 


Ile Phe Lys Gly Val Arg Tyr Gln Gly Glu Asp Lys Lys Ala Val Glu 
                325                 330                 335     


Thr Lys Thr Ile Leu Met Glu Met Lys Ala Tyr His Gln Ile Arg Lys 
            340                 345                 350         


Ala Leu Glu Asn Ala Asp Leu Lys Ala Glu Trp Asn Glu Leu Lys Asn 
        355                 360                 365             


Asn Ser Glu Leu Leu Asp Asp Ile Gly Thr Ala Phe Ser Leu His Lys 
    370                 375                 380                 


Thr Asp Glu Asp Ile Cys Arg Tyr Leu Asp Gly Lys Leu Ser Glu Ser 
385                 390                 395                 400 


Ile Leu Asn Ala Leu Leu Glu Asn Leu Asn Phe Asp Lys Phe Ile Gln 
                405                 410                 415     


Leu Ser Leu Lys Ala Leu Gln Gln Ile Leu Pro Leu Met Leu Gln Gly 
            420                 425                 430         


Gln Arg Tyr Asp Glu Ala Val Ser Ala Ile Tyr Gly Asp His Tyr Gly 
        435                 440                 445             


Lys Lys Ser Ala Glu Ile Asn Arg Leu Leu Pro Thr Ile Pro Ala Asp 
    450                 455                 460                 


Glu Ile Arg Asn Pro Val Val Leu Arg Thr Leu Thr Gln Ala Arg Lys 
465                 470                 475                 480 


Val Ile Asn Ala Val Val Arg Leu Tyr Gly Ser Pro Ala Arg Ile His 
                485                 490                 495     


Ile Glu Thr Gly Arg Glu Val Gly Lys Ser Tyr Gln Asp Arg Lys Lys 
            500                 505                 510         


Leu Glu Lys Gln Gln Glu Asp Asn Arg Lys His Arg Glu Ser Ala Val 
        515                 520                 525             


Gln Lys Phe Lys Glu Tyr Phe Pro Asn Phe Val Gly Glu Pro Lys Gly 
    530                 535                 540                 


Lys Asp Ile Leu Lys Met Arg Leu Tyr Glu Leu Gln Gln Ala Lys Cys 
545                 550                 555                 560 


Leu Tyr Ser Gly Lys Ser Leu Glu Leu His Arg Leu Leu Glu Lys Gly 
                565                 570                 575     


Tyr Val Glu Val Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp 
            580                 585                 590         


Ser Phe Asn Asn Lys Val Leu Val Leu Ala Asn Glu Asn Gln Asn Lys 
        595                 600                 605             


Gly Asn Leu Thr Pro Tyr Glu Trp Leu Asp Gly Lys Asn Asn Ser Glu 
    610                 615                 620                 


Pro Trp Gln Asn Phe Val Ala Arg Val Gln Thr Ser Gly Phe Ser His 
625                 630                 635                 640 


Thr Lys Lys Gln Arg Ile Leu Ser His Lys Leu Asp Glu Lys Gly Phe 
                645                 650                 655     


Ile Glu Arg Asn Leu Asn Asp Thr Arg Tyr Val Val Arg Phe Leu Cys 
            660                 665                 670         


Asn Phe Ile Ala Asp Asn Met Leu Leu Thr Gly Lys Gly Lys Arg Lys 
        675                 680                 685             


Val Phe Ala Ser Asn Gly Gln Ile Thr Ala Leu Leu Arg Gly Arg Trp 
    690                 695                 700                 


Gly Leu Gln Lys Val Arg Asp Asp Asn Asp Arg His His Ala Leu Asp 
705                 710                 715                 720 


Ala Val Val Val Ala Cys Ser Thr Val Ala Met Gln Gln Lys Ile Thr 
                725                 730                 735     


Arg Phe Val Arg Tyr Glu Glu Gly Asn Val Phe Ser Gly Glu Arg Ile 
            740                 745                 750         


Asp Arg Glu Thr Gly Glu Ile Ile Pro Leu His Phe Pro Ser Pro Trp 
        755                 760                 765             


Ala Phe Phe Arg Glu Asn Val Glu Ile Arg Ile Phe Ser Glu Asn Pro 
    770                 775                 780                 


Lys Leu Glu Leu Glu Asn Arg Leu Pro Asp Tyr Pro Gln Tyr Asn His 
785                 790                 795                 800 


Glu Phe Val Gln Pro Leu Phe Val Ser Arg Met Pro Thr Arg Lys Met 
                805                 810                 815     


Thr Gly Gln Gly His Met Glu Thr Val Lys Ser Ala Lys Arg Leu Asp 
            820                 825                 830         


Glu Gly Leu Ser Val Leu Lys Val Pro Leu Thr Gln Leu Lys Leu Asn 
        835                 840                 845             


Asp Leu Glu Arg Met Val Asn Arg Glu Arg Glu Met Ala Leu Tyr Glu 
    850                 855                 860                 


Ser Leu Lys Val Arg Leu Glu Gln Phe Asp Asn Asp Pro Ala Lys Ala 
865                 870                 875                 880 


Phe Ala Glu Pro Phe Tyr Lys Lys Gly Gly Ala Leu Val Lys Ala Val 
                885                 890                 895     


Arg Val Glu Gln Thr Gln Lys Ser Gly Val Leu Val Arg Asp Gly Asn 
            900                 905                 910         


Gly Val Ala Asp Asn Ala Ser Met Val Arg Val Asp Val Phe Thr Lys 
        915                 920                 925             


Ala Gly Lys Tyr Phe Leu Val Pro Ile Tyr Thr Trp Gln Val Ala Lys 
    930                 935                 940                 


Gly Ile Leu Pro Asn Lys Ala Val Thr Ala Asn Val Asp Glu Ile Asp 
945                 950                 955                 960 


Trp Leu Glu Met Asp Glu Ser Tyr Gln Phe Ile Phe Thr Met Tyr Pro 
                965                 970                 975     


Asn Asp Leu Val Lys Val Lys Leu Lys Lys Glu Glu Phe Phe Gly Tyr 
            980                 985                 990         


Tyr Gly Gly Leu Asp Arg Ala Thr  Gly Ala Ile Val Ile  Lys Glu His 
        995                 1000                 1005             


Asp Leu  Glu Lys Ser Lys Gly  Arg Gln Gly Ile Tyr  Arg Ile Gly 
    1010                 1015                 1020             


Val Lys  Leu Ala Leu Ser Phe  Glu Lys Tyr Gln Val  Asp Glu Leu 
    1025                 1030                 1035             


Gly Lys  Asn Ile Arg Pro Cys  Arg Pro Thr Lys Arg  Gln His Val 
    1040                 1045                 1050             


Arg 
    


<210> 47
<211> 1062
<212> PRT
<213> Actinobacillus succinogenes

<400> 47
Met Asn Leu Asn Tyr Ile Leu Gly Leu Asp Leu Gly Ile Ala Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Glu Ile Asp Glu Gln Glu Asn Pro Gln Arg Leu 
            20                  25                  30          


Ile Asp Val Gly Val Arg Thr Phe Asp Arg Ala Glu Val Leu Lys Thr 
        35                  40                  45              


Gly Glu Ser Leu Ala Leu Ala Arg Arg Leu Ala Arg Ser Ser Arg Arg 
    50                  55                  60                  


Leu Val Lys Arg Arg Ala Glu Arg Ile Lys Lys Ala Lys Arg Leu Leu 
65                  70                  75                  80  


Lys Ala Glu Asn Leu Leu Leu Ser Ala Asp Glu Ile Leu Pro Asn Glu 
                85                  90                  95      


Ala Trp Gln Leu Arg Val Lys Gly Leu Asp Gln Lys Leu Glu Arg Gln 
            100                 105                 110         


Glu Trp Ala Ala Val Leu Leu His Leu Leu Lys His Arg Gly Tyr Leu 
        115                 120                 125             


Ser Gln Arg Lys Asn Glu Ser Lys Ser Glu Asn Lys Glu Leu Gly Ala 
    130                 135                 140                 


Leu Leu Ser Gly Val Ala Ile Asn His Gln Ile Leu Gln Ser Ala Glu 
145                 150                 155                 160 


Tyr Arg Thr Pro Ala Glu Ile Ala Val Asn Lys Phe Gln Ala Glu Glu 
                165                 170                 175     


Gly His Ile Arg Asn Gln Arg Gly Ala Tyr Thr His Thr Phe Ser Arg 
            180                 185                 190         


Leu Asp Leu Leu Ala Glu Met Glu Leu Leu Phe Gln Arg Gln Ala Thr 
        195                 200                 205             


Leu Gly Asn Pro His Thr Ser Thr Lys Leu Leu Glu Asn Leu Thr Ala 
    210                 215                 220                 


Leu Leu Met Trp Gln Lys Pro Ala Leu Ala Gly Glu Ala Ile Leu Lys 
225                 230                 235                 240 


Met Leu Gly Lys Cys Thr Phe Glu Pro Thr Glu Tyr Lys Ala Ala Lys 
                245                 250                 255     


Asn Ser Tyr Ser Ala Glu Arg Phe Val Trp Leu Thr Lys Leu Asn Asn 
            260                 265                 270         


Leu Arg Ile Leu Glu Gln Gly Ala Glu Arg Ala Leu Thr Asp Asn Glu 
        275                 280                 285             


Arg Phe Ala Leu Leu Asp Gln Pro Tyr Glu Lys Ala Lys Leu Thr Tyr 
    290                 295                 300                 


Ala Gln Val Arg Thr Leu Leu Gly Leu Ser Asp Glu Ala Ile Phe Lys 
305                 310                 315                 320 


Gly Leu Arg Tyr Gln Gly Glu Asp Lys Lys Ala Val Glu Thr Lys Thr 
                325                 330                 335     


Thr Leu Met Glu Val Lys Ala Tyr His Gln Ile Arg Lys Ala Leu Glu 
            340                 345                 350         


Gly Leu Asp Leu Lys Ala Glu Trp Asn Glu Leu Lys Asn Asn Pro Ala 
        355                 360                 365             


Leu Leu Asp Glu Ile Gly Thr Ala Phe Ser Leu Tyr Lys Thr Asp Asp 
    370                 375                 380                 


Asp Ile His Arg Tyr Leu Asp Gly Lys Leu Ser Glu Ser Val Leu Asn 
385                 390                 395                 400 


Ala Leu Leu Glu Asn Leu Asn Phe Asp Lys Phe Ile Gln Leu Ser Leu 
                405                 410                 415     


Lys Ala Leu Gln Gln Ile Leu Pro Leu Met Leu Gln Gly Gln Arg Tyr 
            420                 425                 430         


Asp Glu Ala Val Ser Ala Ile Tyr Gly Asp His Tyr Gly Lys Lys Ser 
        435                 440                 445             


Asp Glu Ile Asp Arg Leu Leu Pro Asn Ile Pro Thr Asp Glu Ile Arg 
    450                 455                 460                 


Asn Pro Val Val Leu Arg Thr Leu Thr Gln Ala Arg Lys Val Ile Asn 
465                 470                 475                 480 


Ala Val Val Arg Leu Tyr Gly Ser Pro Ala Arg Ile His Ile Glu Thr 
                485                 490                 495     


Gly Arg Glu Val Gly Lys Ser Tyr Gln Asp Arg Lys Lys Leu Glu Lys 
            500                 505                 510         


Gln Gln Glu Glu Asn Arg Lys Gln Arg Glu Asn Ala Val Lys Lys Phe 
        515                 520                 525             


Lys Glu Tyr Phe Pro Asn Phe Val Gly Glu Pro Lys Gly Lys Asp Ile 
    530                 535                 540                 


Leu Lys Met Arg Leu Tyr Glu Leu Gln Gln Ala Lys Cys Leu Tyr Ser 
545                 550                 555                 560 


Gly Lys Ser Leu Glu Leu Tyr Arg Leu Leu Glu Lys Gly Tyr Val Glu 
                565                 570                 575     


Val Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp Ser Phe Asn 
            580                 585                 590         


Asn Lys Val Leu Val Leu Ala Asn Glu Asn Gln Asn Lys Gly Asn Ala 
        595                 600                 605             


Thr Pro Tyr Glu Trp Leu Asp Gly Lys Asn Asn Ser Glu Gly Trp Gln 
    610                 615                 620                 


His Phe Val Ala Arg Val Gln Thr Ser Gly Phe Ser Tyr Ala Lys Lys 
625                 630                 635                 640 


Gln Arg Val Leu Ile Gln Glu Leu Asp Glu Lys Ser Phe Ile Glu Arg 
                645                 650                 655     


Asn Leu Asn Asp Thr Arg Tyr Val Ala Arg Phe Leu Cys Asn His Ile 
            660                 665                 670         


Ala Asp Asn Met Leu Leu Thr Gly Lys Gly Lys Arg Lys Val Phe Ala 
        675                 680                 685             


Ser Asn Gly Gln Ile Thr Ala Leu Leu Arg Gly Cys Trp Gly Leu Gln 
    690                 695                 700                 


Lys Val Arg Glu Asn Asn Asp Arg His His Ala Leu Asp Ala Val Val 
705                 710                 715                 720 


Val Ala Cys Ser Thr Lys Ser Met Gln Asp Lys Ile Thr Lys Phe Val 
                725                 730                 735     


Lys Tyr Lys Glu Gly Arg Leu Phe Lys Asp Lys Lys Asp Gly Val Tyr 
            740                 745                 750         


Lys Gly Glu Arg Ile Asn Arg Glu Thr Gly Glu Ile Ile Ser Leu His 
        755                 760                 765             


Phe Pro Thr Pro Trp Lys Phe Phe Lys Glu Asn Val Glu Ile Arg Ile 
    770                 775                 780                 


Phe Ser Glu Asn Pro Lys Leu Glu Leu Glu Asn Arg Leu Pro Asp Tyr 
785                 790                 795                 800 


Pro Gln Tyr Asn His Glu Phe Val Gln Pro Leu Phe Val Ser Arg Met 
                805                 810                 815     


Pro Thr Arg Lys Met Thr Gly Gln Gly His Met Glu Thr Val Lys Ser 
            820                 825                 830         


Ala Lys Arg Leu Asp Lys Gly Leu Ser Val Leu Lys Val Pro Leu Thr 
        835                 840                 845             


Gln Leu Lys Leu Ser Asp Leu Glu Arg Met Val Asn Arg Glu Arg Glu 
    850                 855                 860                 


Met Ala Leu Tyr Glu Ala Leu Lys Glu Cys Leu Glu Gln Phe Gly Asn 
865                 870                 875                 880 


Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Lys Gly Gly Ala 
                885                 890                 895     


Leu Val Lys Ala Val Arg Val Glu Gln Thr Gln Lys Ser Gly Val Leu 
            900                 905                 910         


Val Arg Asn Gly Asn Gly Val Ala Asp Asn Ala Thr Gly Ser Ile Val 
        915                 920                 925             


Arg Val Asp Val Phe Thr Lys Gly Gly Lys Tyr Phe Leu Val Pro Ile 
    930                 935                 940                 


Tyr Thr Trp Gln Val Ala Lys Gly Ile Leu Pro Asn Lys Ala Val Ile 
945                 950                 955                 960 


Gln Gly Lys Asp Glu Ser Glu Trp Glu Glu Met Asp Glu Asn Ala Val 
                965                 970                 975     


Phe Gln Phe Ser Met His Lys Asn Asp Leu Ile Lys Val Lys Thr Lys 
            980                 985                 990         


Lys Gly Glu Ile Phe Gly Tyr Phe  Asn Gly Leu Asp Arg  Ala Thr Gly 
        995                 1000                 1005             


Ser Ile  Glu Ile Glu Glu His  Asp Leu Glu Lys Ser  Lys Gly Lys 
    1010                 1015                 1020             


Asn Gly  Ser His Arg Gly Leu  Gly Val Lys Thr Ala  Phe Phe Leu 
    1025                 1030                 1035             


Glu Lys  Tyr Gln Val Asp Glu  Leu Gly Lys Asn Ile  Arg Pro Cys 
    1040                 1045                 1050             


Arg Pro  Thr Lys Arg Gln His  Val Arg 
    1055                 1060         


<210> 48
<211> 1054
<212> PRT
<213> Actinobacillus suis

<400> 48
Met Lys Leu Thr Pro Leu Asn Tyr Ile Leu Gly Leu Asp Leu Gly Ile 
1               5                   10                  15      


Ala Ser Val Gly Trp Ala Val Val Glu Ile Asp Glu Gln Glu Asn Pro 
            20                  25                  30          


Leu Gly Leu Ile Asp Val Gly Val Arg Thr Phe Asp Arg Ala Glu Val 
        35                  40                  45              


Pro Lys Thr Gly Glu Ser Leu Ala Leu Ala Arg Arg Leu Ala Arg Ser 
    50                  55                  60                  


Ala Arg Arg Leu Val Lys Arg Arg Ala Asp Arg Ile Lys Lys Ala Lys 
65                  70                  75                  80  


Arg Leu Leu Lys Ala Glu Asn Ile Leu Leu Ser Ala Asp Glu His Leu 
                85                  90                  95      


Pro Asn Asp Val Trp Gln Leu Arg Val Lys Gly Leu Asp Gln Lys Leu 
            100                 105                 110         


Glu Arg Gln Glu Trp Ala Ala Val Leu Leu His Leu Leu Lys His Arg 
        115                 120                 125             


Gly Tyr Leu Ser Gln Arg Lys Asn Glu Ser Lys Ser Glu Asn Lys Glu 
    130                 135                 140                 


Leu Gly Ala Leu Leu Ser Gly Val Glu Thr Asn His Gln Ile Leu Gln 
145                 150                 155                 160 


Ser Ala Glu Tyr Arg Thr Pro Ala Glu Ile Ala Val Lys Lys Phe His 
                165                 170                 175     


Val Glu Asp Gly His Ile Arg Asn Gln Arg Gly Ala Tyr Thr His Thr 
            180                 185                 190         


Phe Ser Arg Leu Asp Leu Leu Ala Glu Met Glu Leu Leu Phe Gln Arg 
        195                 200                 205             


Gln Thr Asp Leu Gly Asn Pro His Thr Ser Ala Lys Leu Leu Glu Asn 
    210                 215                 220                 


Leu Thr Ala Leu Leu Met Trp Gln Lys Pro Ala Leu Ala Gly Glu Ala 
225                 230                 235                 240 


Ile Leu Lys Met Leu Gly Lys Cys Thr Phe Glu Pro Thr Glu Tyr Lys 
                245                 250                 255     


Ala Ala Lys Asn Ser Tyr Ser Ala Glu Arg Phe Val Trp Leu Thr Lys 
            260                 265                 270         


Leu Asn Asn Leu Arg Ile Leu Glu Gln Gly Ala Glu Arg Ala Leu Thr 
        275                 280                 285             


Asp Asn Glu Arg Phe Ala Leu Leu Asp Gln Pro Tyr Glu Lys Ala Lys 
    290                 295                 300                 


Phe Thr Tyr Ala Gln Ala Arg Thr Met Leu Ala Leu Pro Asp Glu Ala 
305                 310                 315                 320 


Ile Phe Lys Gly Val Arg Tyr Gln Gly Glu Asp Lys Lys Ala Val Glu 
                325                 330                 335     


Thr Lys Thr Ile Leu Met Glu Met Lys Ala Tyr His Gln Ile Arg Lys 
            340                 345                 350         


Ala Leu Glu Asn Ala Asp Leu Lys Ala Glu Trp Asn Glu Leu Lys Asn 
        355                 360                 365             


Asn Ser Glu Leu Leu Asp Asp Ile Gly Thr Ala Phe Ser Leu His Lys 
    370                 375                 380                 


Thr Asp Glu Asp Ile Cys Arg Tyr Leu Asp Gly Lys Leu Ser Glu Ser 
385                 390                 395                 400 


Ile Leu Asn Ala Leu Leu Glu Asn Leu Asn Phe Asp Lys Phe Ile Gln 
                405                 410                 415     


Leu Ser Leu Lys Ala Leu Gln Gln Ile Leu Pro Leu Met Leu Gln Gly 
            420                 425                 430         


Gln Arg Tyr Asp Glu Ala Val Ser Ala Ile Tyr Gly Asp His Tyr Gly 
        435                 440                 445             


Lys Lys Ser Ala Glu Ile Asn Arg Leu Leu Pro Thr Ile Pro Ala Asp 
    450                 455                 460                 


Glu Ile Arg Asn Pro Val Val Leu Arg Thr Leu Thr Gln Ala Arg Lys 
465                 470                 475                 480 


Val Ile Asn Ala Val Val Arg Leu Tyr Gly Ser Pro Ala Arg Ile His 
                485                 490                 495     


Ile Glu Thr Gly Arg Glu Val Gly Lys Ser Tyr Gln Asp Arg Lys Lys 
            500                 505                 510         


Leu Glu Lys Gln Gln Glu Asp Asn Arg Lys Gln Arg Glu Ser Ala Val 
        515                 520                 525             


Lys Lys Phe Lys Glu Tyr Phe Pro Asn Phe Val Gly Glu Pro Lys Gly 
    530                 535                 540                 


Lys Asp Ile Leu Lys Met Arg Leu Tyr Glu Leu Gln Gln Ala Lys Cys 
545                 550                 555                 560 


Leu Tyr Ser Gly Lys Ser Leu Glu Leu His Arg Leu Leu Glu Lys Gly 
                565                 570                 575     


Tyr Val Glu Val Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp 
            580                 585                 590         


Ser Phe Asn Asn Lys Val Leu Val Leu Ala Asn Glu Asn Gln Asn Lys 
        595                 600                 605             


Gly Asn Leu Thr Pro Tyr Glu Trp Leu Asp Gly Lys Asn Asn Ser Glu 
    610                 615                 620                 


His Trp Gln Asn Phe Val Ala Arg Val Gln Thr Ser Gly Phe Ser His 
625                 630                 635                 640 


Thr Lys Lys Gln Arg Ile Leu Ser His Lys Leu Asp Glu Lys Gly Phe 
                645                 650                 655     


Ile Glu Arg Asn Leu Asn Asp Thr Arg Tyr Val Ala Arg Phe Leu Cys 
            660                 665                 670         


Asn Phe Ile Ala Asp Asn Met Leu Leu Thr Gly Lys Gly Lys Arg Lys 
        675                 680                 685             


Val Phe Ala Ser Asn Gly Gln Ile Thr Ala Leu Leu Arg Gly Arg Trp 
    690                 695                 700                 


Gly Leu Gln Lys Val Arg Asp Asp Asn Asp Arg His His Ala Leu Asp 
705                 710                 715                 720 


Ala Val Val Val Ala Cys Ser Thr Val Val Met Gln Gln Lys Ile Thr 
                725                 730                 735     


Arg Phe Val Arg Tyr Glu Glu Gly Asn Val Phe Ser Gly Glu Arg Ile 
            740                 745                 750         


Asp Arg Glu Thr Gly Glu Ile Ile Pro Leu His Phe Pro Ser Pro Trp 
        755                 760                 765             


Ala Phe Phe Arg Glu Asn Val Glu Ile Arg Ile Phe Ser Glu Asn Pro 
    770                 775                 780                 


Lys Leu Glu Leu Glu Asn Arg Leu Pro Asp Tyr Pro Gln Tyr Asn His 
785                 790                 795                 800 


Glu Phe Val Gln Pro Leu Phe Val Ser Arg Met Pro Thr Arg Lys Met 
                805                 810                 815     


Thr Gly Gln Gly His Met Glu Thr Val Lys Ser Ala Lys Arg Leu Asp 
            820                 825                 830         


Glu Gly Leu Ser Val Leu Lys Val Pro Leu Thr Gln Leu Lys Leu Ser 
        835                 840                 845             


Asp Leu Glu Arg Met Val Asn Arg Glu Arg Glu Val Thr Leu Tyr Glu 
    850                 855                 860                 


Ser Leu Lys Ala Arg Leu Glu Gln Phe Gly Asn Asp Pro Ala Lys Ala 
865                 870                 875                 880 


Phe Ala Glu Pro Phe His Lys Lys Gly Gly Ala Val Val Lys Ala Val 
                885                 890                 895     


Arg Val Glu Gln Thr Gln Lys Ser Gly Val Leu Val Arg Asp Gly Asn 
            900                 905                 910         


Gly Val Ala Asp Asn Ala Ser Met Val Arg Val Asp Val Phe Thr Lys 
        915                 920                 925             


Gly Gly Lys Tyr Phe Leu Val Pro Ile Tyr Thr Trp Gln Val Ala Lys 
    930                 935                 940                 


Gly Ile Leu Pro Asn Lys Ala Val Thr Ala Asn Val Asp Glu Ile Asp 
945                 950                 955                 960 


Trp Leu Glu Met Asp Glu Ser Tyr Gln Phe Ile Phe Thr Met Tyr Pro 
                965                 970                 975     


Asn Asp Leu Val Lys Val Lys Leu Lys Lys Glu Glu Phe Phe Gly Tyr 
            980                 985                 990         


Tyr Gly Gly Leu Asp Arg Ala Thr  Gly Ala Ile Val Ile  Lys Glu His 
        995                 1000                 1005             


Asp Leu  Glu Lys Ser Lys Gly  Lys Gln Gly Ile Tyr  Arg Ile Gly 
    1010                 1015                 1020             


Val Lys  Leu Ala Leu Ser Phe  Glu Lys Tyr Gln Val  Asp Glu Leu 
    1025                 1030                 1035             


Gly Lys  Asn Ile Arg Pro Cys  Arg Pro Thr Lys Arg  Gln His Val 
    1040                 1045                 1050             


Arg 
    


<210> 49
<211> 1105
<212> PRT
<213> Actinomyces coleocanis


<220>
<223> Actinomyces coleocanis DSM 15436

<400> 49
Met Asp Asn Lys Asn Tyr Arg Ile Gly Ile Asp Val Gly Leu Asn Ser 
1               5                   10                  15      


Ile Gly Phe Cys Ala Val Glu Val Asp Gln His Asp Thr Pro Leu Gly 
            20                  25                  30          


Phe Leu Asn Leu Ser Val Tyr Arg His Asp Ala Gly Ile Asp Pro Asn 
        35                  40                  45              


Gly Lys Lys Thr Asn Thr Thr Arg Leu Ala Met Ser Gly Val Ala Arg 
    50                  55                  60                  


Arg Thr Arg Arg Leu Phe Arg Lys Arg Lys Arg Arg Leu Ala Ala Leu 
65                  70                  75                  80  


Asp Arg Phe Ile Glu Ala Gln Gly Trp Thr Leu Pro Asp His Ala Asp 
                85                  90                  95      


Tyr Lys Asp Pro Tyr Thr Pro Trp Leu Val Arg Ala Glu Leu Ala Gln 
            100                 105                 110         


Thr Pro Ile Arg Asp Glu Asn Asp Leu His Glu Lys Leu Ala Ile Ala 
        115                 120                 125             


Val Arg His Ile Ala Arg His Arg Gly Trp Arg Ser Pro Trp Val Pro 
    130                 135                 140                 


Val Arg Ser Leu His Val Glu Gln Pro Pro Ser Asp Gln Tyr Leu Ala 
145                 150                 155                 160 


Leu Lys Glu Arg Val Glu Ala Lys Thr Leu Leu Gln Met Pro Glu Gly 
                165                 170                 175     


Ala Thr Pro Ala Glu Met Val Val Ala Leu Asp Leu Ser Val Asp Val 
            180                 185                 190         


Asn Leu Arg Pro Lys Asn Arg Glu Lys Thr Asp Thr Arg Pro Glu Asn 
        195                 200                 205             


Lys Lys Pro Gly Phe Leu Gly Gly Lys Leu Met Gln Ser Asp Asn Ala 
    210                 215                 220                 


Asn Glu Leu Arg Lys Ile Ala Lys Ile Gln Gly Leu Asp Asp Ala Leu 
225                 230                 235                 240 


Leu Arg Glu Leu Ile Glu Leu Val Phe Ala Ala Asp Ser Pro Lys Gly 
                245                 250                 255     


Ala Ser Gly Glu Leu Val Gly Tyr Asp Val Leu Pro Gly Gln His Gly 
            260                 265                 270         


Lys Arg Arg Ala Glu Lys Ala His Pro Ala Phe Gln Arg Tyr Arg Ile 
        275                 280                 285             


Ala Ser Ile Val Ser Asn Leu Arg Ile Arg His Leu Gly Ser Gly Ala 
    290                 295                 300                 


Asp Glu Arg Leu Asp Val Glu Thr Gln Lys Arg Val Phe Glu Tyr Leu 
305                 310                 315                 320 


Leu Asn Ala Lys Pro Thr Ala Asp Ile Thr Trp Ser Asp Val Ala Glu 
                325                 330                 335     


Glu Ile Gly Val Glu Arg Asn Leu Leu Met Gly Thr Ala Thr Gln Thr 
            340                 345                 350         


Ala Asp Gly Glu Arg Ala Ser Ala Lys Pro Pro Val Asp Val Thr Asn 
        355                 360                 365             


Val Ala Phe Ala Thr Cys Lys Ile Lys Pro Leu Lys Glu Trp Trp Leu 
    370                 375                 380                 


Asn Ala Asp Tyr Glu Ala Arg Cys Val Met Val Ser Ala Leu Ser His 
385                 390                 395                 400 


Ala Glu Lys Leu Thr Glu Gly Thr Ala Ala Glu Val Glu Val Ala Glu 
                405                 410                 415     


Phe Leu Gln Asn Leu Ser Asp Glu Asp Asn Glu Lys Leu Asp Ser Phe 
            420                 425                 430         


Ser Leu Pro Ile Gly Arg Ala Ala Tyr Ser Val Asp Ser Leu Glu Arg 
        435                 440                 445             


Leu Thr Lys Arg Met Ile Glu Asn Gly Glu Asp Leu Phe Glu Ala Arg 
    450                 455                 460                 


Val Asn Glu Phe Gly Val Ser Glu Asp Trp Arg Pro Pro Ala Glu Pro 
465                 470                 475                 480 


Ile Gly Ala Arg Val Gly Asn Pro Ala Val Asp Arg Val Leu Lys Ala 
                485                 490                 495     


Val Asn Arg Tyr Leu Met Ala Ala Glu Ala Glu Trp Gly Ala Pro Leu 
            500                 505                 510         


Ser Val Asn Ile Glu His Val Arg Glu Gly Phe Ile Ser Lys Arg Gln 
        515                 520                 525             


Ala Val Glu Ile Asp Arg Glu Asn Gln Lys Arg Tyr Gln Arg Asn Gln 
    530                 535                 540                 


Ala Val Arg Ser Gln Ile Ala Asp His Ile Asn Ala Thr Ser Gly Val 
545                 550                 555                 560 


Arg Gly Ser Asp Val Thr Arg Tyr Leu Ala Ile Gln Arg Gln Asn Gly 
                565                 570                 575     


Glu Cys Leu Tyr Cys Gly Thr Ala Ile Thr Phe Val Asn Ser Glu Met 
            580                 585                 590         


Asp His Ile Val Pro Arg Ala Gly Leu Gly Ser Thr Asn Thr Arg Asp 
        595                 600                 605             


Asn Leu Val Ala Thr Cys Glu Arg Cys Asn Lys Ser Lys Ser Asn Lys 
    610                 615                 620                 


Pro Phe Ala Val Trp Ala Ala Glu Cys Gly Ile Pro Gly Val Ser Val 
625                 630                 635                 640 


Ala Glu Ala Leu Lys Arg Val Asp Phe Trp Ile Ala Asp Gly Phe Ala 
                645                 650                 655     


Ser Ser Lys Glu His Arg Glu Leu Gln Lys Gly Val Lys Asp Arg Leu 
            660                 665                 670         


Lys Arg Lys Val Ser Asp Pro Glu Ile Asp Asn Arg Ser Met Glu Ser 
        675                 680                 685             


Val Ala Trp Met Ala Arg Glu Leu Ala His Arg Val Gln Tyr Tyr Phe 
    690                 695                 700                 


Asp Glu Lys His Thr Gly Thr Lys Val Arg Val Phe Arg Gly Ser Leu 
705                 710                 715                 720 


Thr Ser Ala Ala Arg Lys Ala Ser Gly Phe Glu Ser Arg Val Asn Phe 
                725                 730                 735     


Ile Gly Gly Asn Gly Lys Thr Arg Leu Asp Arg Arg His His Ala Met 
            740                 745                 750         


Asp Ala Ala Thr Val Ala Met Leu Arg Asn Ser Val Ala Lys Thr Leu 
        755                 760                 765             


Val Leu Arg Gly Asn Ile Arg Ala Ser Glu Arg Ala Ile Gly Ala Ala 
    770                 775                 780                 


Glu Thr Trp Lys Ser Phe Arg Gly Glu Asn Val Ala Asp Arg Gln Ile 
785                 790                 795                 800 


Phe Glu Ser Trp Ser Glu Asn Met Arg Val Leu Val Glu Lys Phe Asn 
                805                 810                 815     


Leu Ala Leu Tyr Asn Asp Glu Val Ser Ile Phe Ser Ser Leu Arg Leu 
            820                 825                 830         


Gln Leu Gly Asn Gly Lys Ala His Asp Asp Thr Ile Thr Lys Leu Gln 
        835                 840                 845             


Met His Lys Val Gly Asp Ala Trp Ser Leu Thr Glu Ile Asp Arg Ala 
    850                 855                 860                 


Ser Thr Pro Ala Leu Trp Cys Ala Leu Thr Arg Gln Pro Asp Phe Thr 
865                 870                 875                 880 


Trp Lys Asp Gly Leu Pro Ala Asn Glu Asp Arg Thr Ile Ile Val Asn 
                885                 890                 895     


Gly Thr His Tyr Gly Pro Leu Asp Lys Val Gly Ile Phe Gly Lys Ala 
            900                 905                 910         


Ala Ala Ser Leu Leu Val Arg Gly Gly Ser Val Asp Ile Gly Ser Ala 
        915                 920                 925             


Ile His His Ala Arg Ile Tyr Arg Ile Ala Gly Lys Lys Pro Thr Tyr 
    930                 935                 940                 


Gly Met Val Arg Val Phe Ala Pro Asp Leu Leu Arg Tyr Arg Asn Glu 
945                 950                 955                 960 


Asp Leu Phe Asn Val Glu Leu Pro Pro Gln Ser Val Ser Met Arg Tyr 
                965                 970                 975     


Ala Glu Pro Lys Val Arg Glu Ala Ile Arg Glu Gly Lys Ala Glu Tyr 
            980                 985                 990         


Leu Gly Trp Leu Val Val Gly Asp  Glu Leu Leu Leu Asp  Leu Ser Ser 
        995                 1000                 1005             


Glu Thr  Ser Gly Gln Ile Ala  Glu Leu Gln Gln Asp  Phe Pro Gly 
    1010                 1015                 1020             


Thr Thr  His Trp Thr Val Ala  Gly Phe Phe Ser Pro  Ser Arg Leu 
    1025                 1030                 1035             


Arg Leu  Arg Pro Val Tyr Leu  Ala Gln Glu Gly Leu  Gly Glu Asp 
    1040                 1045                 1050             


Val Ser  Glu Gly Ser Lys Ser  Ile Ile Ala Gly Gln  Gly Trp Arg 
    1055                 1060                 1065             


Pro Ala  Val Asn Lys Val Phe  Gly Ser Ala Met Pro  Glu Val Ile 
    1070                 1075                 1080             


Arg Arg  Asp Gly Leu Gly Arg  Lys Arg Arg Phe Ser  Tyr Ser Gly 
    1085                 1090                 1095             


Leu Pro  Val Ser Trp Gln Gly  
    1100                 1105 


<210> 50
<211> 1113
<212> PRT
<213> Actinomyces georgiae


<220>
<223> Actinomyces georgiae F0490

<400> 50
Met Ser Ala Ser Ser Gln Asn Val Glu Arg Ile Arg Tyr Lys Val Gly 
1               5                   10                  15      


Ile Asp Val Gly Leu Arg Ser Ile Gly Phe Cys Ala Val Gln Val Asp 
            20                  25                  30          


Ala Asp Asp Arg Pro Val Lys Leu Leu Asn Thr Val Val His Val His 
        35                  40                  45              


Asp Ala Gly Val Ser Pro Ala Asp Ala Lys Lys Ala Asp Thr Arg Lys 
    50                  55                  60                  


Leu Val Ser Gly Val Ala Arg Arg Thr Arg Arg Leu Tyr Arg Thr Arg 
65                  70                  75                  80  


Lys Arg Arg Leu Val Asp Leu Asp Arg Gln Leu Asp Gly Leu Gly Trp 
                85                  90                  95      


Pro Leu Val Asp Pro Ala Arg Phe Ala Asp Pro Arg Glu Pro Trp Phe 
            100                 105                 110         


Ala Arg Glu Lys Leu Val Ser Gly Arg Val Asp Asp Ala Asp Glu Arg 
        115                 120                 125             


Lys Glu Leu Leu Ser Val Ala Leu Arg His Ile Ala His His Arg Gly 
    130                 135                 140                 


Trp Arg Asn Pro Tyr Ser Thr Val Glu Ser Leu Gln Ala Asp Ala Pro 
145                 150                 155                 160 


Pro Ser Glu Phe Leu Gln Gly Leu Asn Gln Arg Val Ser Glu Lys Leu 
                165                 170                 175     


Gly Thr Glu Leu Asp Pro Gly Leu Thr Gln Gly Gln Leu Val Ala Lys 
            180                 185                 190         


Leu Leu His Arg Phe Pro Asn Ala Lys Ile Arg Gly Pro Glu Gly Ile 
        195                 200                 205             


Leu Arg Gly Lys Leu His Gln Ser Asp Asn Ala Gly Glu Leu Arg Leu 
    210                 215                 220                 


Ile Cys Arg Thr Gln Gly Leu Asp Cys His Ile Thr Glu Glu Leu Val 
225                 230                 235                 240 


Arg Leu Val Phe Gln Ala Lys Ser Pro Lys Ala Asn Lys Glu Met Arg 
                245                 250                 255     


Lys Arg Ile Gly Arg Asp Gln Leu Pro Gly Gln Gly Ala His Ile Arg 
            260                 265                 270         


Ala Glu Lys Ala His Pro Val Phe Gln Arg Phe Arg Ile Val Ala Val 
        275                 280                 285             


Leu Ala Asn Leu Arg Ile Arg Glu Ala His Val Asp Arg Arg Leu Thr 
    290                 295                 300                 


Ala Glu Glu Met Arg Thr Leu Thr Asp Phe Leu Leu Gly Leu Ala Gly 
305                 310                 315                 320 


Ser Glu Gln Pro Thr Trp Glu Glu Leu Ala Asp Asn Leu Asn Ile Glu 
                325                 330                 335     


Arg His Gln Leu Arg Gly Thr Ala Lys Ala Ser Val Asp Gly Ala Pro 
            340                 345                 350         


Ala Leu Arg Phe Pro Pro Ile Asp Ala Thr Thr Asp Arg Ile Tyr Ala 
        355                 360                 365             


Ser Lys Leu Lys Trp Leu Ala Glu Trp Trp Arg Gln Ala Asp Glu Glu 
    370                 375                 380                 


Arg Arg Gly Tyr Met Val Asp Ala Leu Ser Asn Ser Gly Gly Ser Glu 
385                 390                 395                 400 


Asp Glu Pro Tyr Leu Asp Asp Glu Ile Ala Glu Met Leu Glu Gln Ala 
                405                 410                 415     


Ser Glu Glu Asp Gln Ala Lys Leu Asp Ser Leu His Leu Pro Gly Gly 
            420                 425                 430         


Arg Ala Ser Tyr Cys Leu Asp Thr Leu Arg Arg Leu Thr Asp Ala Met 
        435                 440                 445             


Leu Gly Gly Gly Leu Asp Leu Phe Glu Ala Arg Lys Ala Val Phe His 
    450                 455                 460                 


Val Asp Asp Asp Trp Ala Pro Pro Thr Asp Pro Ile Gly Ala Pro Val 
465                 470                 475                 480 


Gly Asn Pro Pro Val Asp Arg Val Leu Lys His Val Ala Arg Trp Leu 
                485                 490                 495     


Glu Ala Ala Thr Gly Arg Trp Gly Ala Pro Gln Thr Ile Asn Ile Glu 
            500                 505                 510         


His Val Arg Glu Gly Leu Gly Ser Glu Lys Ala Ala Arg Glu Leu Thr 
        515                 520                 525             


Arg Met Asn Asp Arg Arg Arg Arg Asn Asn Gln Lys Leu Val Glu Glu 
    530                 535                 540                 


Met Gly Glu Lys Leu Gly Met Ser Gly Arg Ile Arg Arg Ser Asp Arg 
545                 550                 555                 560 


Met Arg Tyr Glu Ala Ile Arg Arg Gln Asn Cys Glu Cys Leu Tyr Cys 
                565                 570                 575     


Gly Gln Pro Ile Thr Tyr Gln Thr Met Glu Met Asp His Ile Val Pro 
            580                 585                 590         


Arg Ala Gly Ala Ala Ser Thr Asn Ser Arg Ser Asn Leu Ala Ala Val 
        595                 600                 605             


Cys Arg Arg Cys Asn His Gln Lys Gly Lys Leu Pro Phe Ala Val Trp 
    610                 615                 620                 


Ala Glu Ser Gln Asp Ser Pro Ala Glu Val Arg Leu Gln Asp Ala Val 
625                 630                 635                 640 


Gln Arg Val Arg His Trp Leu Arg Asp Ala Gly Met Gly Gln Lys Glu 
                645                 650                 655     


Leu Gln Ala Leu Arg Val Gln Val Ile Ala Arg Leu Lys Ser Lys Arg 
            660                 665                 670         


Pro Asp Glu Glu Phe Asp Gly Arg Ser Met Glu Ser Ile Ala Trp Met 
        675                 680                 685             


Ala Asn Glu Leu Arg Ala Arg Val Glu Ala Gln Tyr Arg Gly Ser Gly 
    690                 695                 700                 


Thr Thr Val Arg Val Tyr Arg Gly Ala Leu Thr Ala Glu Ala Arg Lys 
705                 710                 715                 720 


Ala Ser Gly Phe Glu Gly Arg Val Asn Leu Ile Gly Gly Arg Gly Lys 
                725                 730                 735     


Asp Arg Phe Asp Arg Arg His His Ala Met Asp Ala Leu Val Ile Ala 
            740                 745                 750         


Leu Met Asn Gln Ser Val Ala Gln Thr Leu Ala Leu Arg Leu Asn Met 
        755                 760                 765             


Arg Asp Ser Gln Trp Leu Thr Gln Ser Glu Gln Thr Trp Arg Gln Phe 
    770                 775                 780                 


His Gly Ala Pro Gly Glu Ala Ala Arg Lys Trp Glu Ala Trp Asp Arg 
785                 790                 795                 800 


Asp Met Arg Asp Ala Ser Asp Leu Phe Asn Leu Ala Leu Asp Gly Gly 
                805                 810                 815     


Arg Ile Pro Ile Thr Glu Asn Val Arg Leu Arg Val Gly Asn Gly Arg 
            820                 825                 830         


Val His Glu Asp Gly Val Ile Arg Phe Lys Pro Glu Tyr Glu Val Lys 
        835                 840                 845             


Gly Lys Thr Ile Lys Gly Gly Glu Ala Arg Leu Leu Gly Asp Ser Leu 
    850                 855                 860                 


Pro Ser Glu Gln Ile Asp Arg Ala Glu Thr Pro Ala Leu Trp Thr Ala 
865                 870                 875                 880 


Leu Thr Arg Leu Pro Glu Tyr Asp Arg Lys Ser Gly Leu Pro Glu Asn 
                885                 890                 895     


Pro Asp Arg Val Ile Arg Val Asn Gly Ala Val Val Gln Ala Thr Asp 
            900                 905                 910         


Arg Ile Arg Phe Phe Gly Thr Pro Ala Ser Val Ala Val Arg Gly Gly 
        915                 920                 925             


Tyr Ala Lys Leu Gly Glu Ser Ile His His Ala Arg Ile Tyr Arg Ile 
    930                 935                 940                 


Asn Gly Lys Thr Pro Lys Tyr Ala Met Ile Arg Val Tyr Thr Ile Asp 
945                 950                 955                 960 


Leu Met Arg Leu Asn His Glu Asp Ile Phe Thr Ala Val Leu Lys Pro 
                965                 970                 975     


Ser Thr Ile Ser Met Arg Cys Ala Glu Lys Lys Leu Lys Tyr Ala Ile 
            980                 985                 990         


Ala Glu Gly Asn Ala Glu Gln Ile  Gly Trp Leu Val Glu  Gly Asp Gln 
        995                 1000                 1005             


Leu Glu  Leu Asp Ala Ala Ala  Tyr Ala Lys Gly Val  Gly Ala Asp 
    1010                 1015                 1020             


Leu Met  Arg Glu Tyr Pro Met  Ala Thr Cys Trp Arg  Val Ala Gly 
    1025                 1030                 1035             


Phe Pro  Asp Glu Ala Lys Leu  Arg Leu Arg Pro Val  Leu Leu Ala 
    1040                 1045                 1050             


Ala Glu  Gly Met Gly Glu Asp  Ala Pro Lys Phe Met  Arg Glu Val 
    1055                 1060                 1065             


Leu Glu  Asn Gln Gly Trp Arg  Pro Ala Val Asn Ala  Leu Leu Ser 
    1070                 1075                 1080             


Pro Gly  Ser Val Arg Val Val  Arg Arg Asn Val Leu  Gly Glu Pro 
    1085                 1090                 1095             


Arg Phe  Lys Ser Ser Gly His  Leu Pro Thr Thr Val  Asp Leu Val 
    1100                 1105                 1110             


<210> 51
<211> 1101
<212> PRT
<213> Actinomyces naeslundii


<220>
<223> Actinomyces naeslundii str. Howell 279

<400> 51
Met Trp Tyr Ala Ser Leu Met Ser Ala His His Leu Arg Val Gly Ile 
1               5                   10                  15      


Asp Val Gly Thr His Ser Val Gly Leu Ala Thr Leu Arg Val Asp Asp 
            20                  25                  30          


His Gly Thr Pro Ile Glu Leu Leu Ser Ala Leu Ser His Ile His Asp 
        35                  40                  45              


Ser Gly Val Gly Lys Glu Gly Lys Lys Asp His Asp Thr Arg Lys Lys 
    50                  55                  60                  


Leu Ser Gly Ile Ala Arg Arg Ala Arg Arg Leu Leu His His Arg Arg 
65                  70                  75                  80  


Thr Gln Leu Gln Gln Leu Asp Glu Val Leu Arg Asp Leu Gly Phe Pro 
                85                  90                  95      


Ile Pro Thr Pro Gly Glu Phe Leu Asp Leu Asn Glu Gln Thr Asp Pro 
            100                 105                 110         


Tyr Arg Val Trp Arg Val Arg Ala Arg Leu Val Glu Glu Lys Leu Pro 
        115                 120                 125             


Glu Glu Leu Arg Gly Pro Ala Ile Ser Met Ala Val Arg His Ile Ala 
    130                 135                 140                 


Arg His Arg Gly Trp Arg Asn Pro Tyr Ser Lys Val Glu Ser Leu Leu 
145                 150                 155                 160 


Ser Pro Ala Glu Glu Ser Pro Phe Met Lys Ala Leu Arg Glu Arg Ile 
                165                 170                 175     


Leu Ala Thr Thr Gly Glu Val Leu Asp Asp Gly Ile Thr Pro Gly Gln 
            180                 185                 190         


Ala Met Ala Gln Val Ala Leu Thr His Asn Ile Ser Met Arg Gly Pro 
        195                 200                 205             


Glu Gly Ile Leu Gly Lys Leu His Gln Ser Asp Asn Ala Asn Glu Ile 
    210                 215                 220                 


Arg Lys Ile Cys Ala Arg Gln Gly Val Ser Pro Asp Val Cys Lys Gln 
225                 230                 235                 240 


Leu Leu Arg Ala Val Phe Lys Ala Asp Ser Pro Arg Gly Ser Ala Val 
                245                 250                 255     


Ser Arg Val Ala Pro Asp Pro Leu Pro Gly Gln Gly Ser Phe Arg Arg 
            260                 265                 270         


Ala Pro Lys Cys Asp Pro Glu Phe Gln Arg Phe Arg Ile Ile Ser Ile 
        275                 280                 285             


Val Ala Asn Leu Arg Ile Ser Glu Thr Lys Gly Glu Asn Arg Pro Leu 
    290                 295                 300                 


Thr Ala Asp Glu Arg Arg His Val Val Thr Phe Leu Thr Glu Asp Ser 
305                 310                 315                 320 


Gln Ala Asp Leu Thr Trp Val Asp Val Ala Glu Lys Leu Gly Val His 
                325                 330                 335     


Arg Arg Asp Leu Arg Gly Thr Ala Val His Thr Asp Asp Gly Glu Arg 
            340                 345                 350         


Ser Ala Ala Arg Pro Pro Ile Asp Ala Thr Asp Arg Ile Met Arg Gln 
        355                 360                 365             


Thr Lys Ile Ser Ser Leu Lys Thr Trp Trp Glu Glu Ala Asp Ser Glu 
    370                 375                 380                 


Gln Arg Gly Ala Met Ile Arg Tyr Leu Tyr Glu Asp Pro Thr Asp Ser 
385                 390                 395                 400 


Glu Cys Ala Glu Ile Ile Ala Glu Leu Pro Glu Glu Asp Gln Ala Lys 
                405                 410                 415     


Leu Asp Ser Leu His Leu Pro Ala Gly Arg Ala Ala Tyr Ser Arg Glu 
            420                 425                 430         


Ser Leu Thr Ala Leu Ser Asp His Met Leu Ala Thr Thr Asp Asp Leu 
        435                 440                 445             


His Glu Ala Arg Lys Arg Leu Phe Gly Val Asp Asp Ser Trp Ala Pro 
    450                 455                 460                 


Pro Ala Glu Ala Ile Asn Ala Pro Val Gly Asn Pro Ser Val Asp Arg 
465                 470                 475                 480 


Thr Leu Lys Ile Val Gly Arg Tyr Leu Ser Ala Val Glu Ser Met Trp 
                485                 490                 495     


Gly Thr Pro Glu Val Ile His Val Glu His Val Arg Asp Gly Phe Thr 
            500                 505                 510         


Ser Glu Arg Met Ala Asp Glu Arg Asp Lys Ala Asn Arg Arg Arg Tyr 
        515                 520                 525             


Asn Asp Asn Gln Glu Ala Met Lys Lys Ile Gln Arg Asp Tyr Gly Lys 
    530                 535                 540                 


Glu Gly Tyr Ile Ser Arg Gly Asp Ile Val Arg Leu Asp Ala Leu Glu 
545                 550                 555                 560 


Leu Gln Gly Cys Ala Cys Leu Tyr Cys Gly Thr Thr Ile Gly Tyr His 
                565                 570                 575     


Thr Cys Gln Leu Asp His Ile Val Pro Gln Ala Gly Pro Gly Ser Asn 
            580                 585                 590         


Asn Arg Arg Gly Asn Leu Val Ala Val Cys Glu Arg Cys Asn Arg Ser 
        595                 600                 605             


Lys Ser Asn Thr Pro Phe Ala Val Trp Ala Gln Lys Cys Gly Ile Pro 
    610                 615                 620                 


His Val Gly Val Lys Glu Ala Ile Gly Arg Val Arg Gly Trp Arg Lys 
625                 630                 635                 640 


Gln Thr Pro Asn Thr Ser Ser Glu Asp Leu Thr Arg Leu Lys Lys Glu 
                645                 650                 655     


Val Ile Ala Arg Leu Arg Arg Thr Gln Glu Asp Pro Glu Ile Asp Glu 
            660                 665                 670         


Arg Ser Met Glu Ser Val Ala Trp Met Ala Asn Glu Leu His His Arg 
        675                 680                 685             


Ile Ala Ala Ala Tyr Pro Glu Thr Thr Val Met Val Tyr Arg Gly Ser 
    690                 695                 700                 


Ile Thr Ala Ala Ala Arg Lys Ala Ala Gly Ile Asp Ser Arg Ile Asn 
705                 710                 715                 720 


Leu Ile Gly Glu Lys Gly Arg Lys Asp Arg Ile Asp Arg Arg His His 
                725                 730                 735     


Ala Val Asp Ala Ser Val Val Ala Leu Met Glu Ala Ser Val Ala Lys 
            740                 745                 750         


Thr Leu Ala Glu Arg Ser Ser Leu Arg Gly Glu Gln Arg Leu Thr Gly 
        755                 760                 765             


Lys Glu Gln Thr Trp Lys Gln Tyr Thr Gly Ser Thr Val Gly Ala Arg 
    770                 775                 780                 


Glu His Phe Glu Met Trp Arg Gly His Met Leu His Leu Thr Glu Leu 
785                 790                 795                 800 


Phe Asn Glu Arg Leu Ala Glu Asp Lys Val Tyr Val Thr Gln Asn Ile 
                805                 810                 815     


Arg Leu Arg Leu Ser Asp Gly Asn Ala His Thr Val Asn Pro Ser Lys 
            820                 825                 830         


Leu Val Ser His Arg Leu Gly Asp Gly Leu Thr Val Gln Gln Ile Asp 
        835                 840                 845             


Arg Ala Cys Thr Pro Ala Leu Trp Cys Ala Leu Thr Arg Glu Lys Asp 
    850                 855                 860                 


Phe Asp Glu Lys Asn Gly Leu Pro Ala Arg Glu Asp Arg Ala Ile Arg 
865                 870                 875                 880 


Val His Gly His Glu Ile Lys Ser Ser Asp Tyr Ile Gln Val Phe Ser 
                885                 890                 895     


Lys Arg Lys Lys Thr Asp Ser Asp Arg Asp Glu Thr Pro Phe Gly Ala 
            900                 905                 910         


Ile Ala Val Arg Gly Gly Phe Val Glu Ile Gly Pro Ser Ile His His 
        915                 920                 925             


Ala Arg Ile Tyr Arg Val Glu Gly Lys Lys Pro Val Tyr Ala Met Leu 
    930                 935                 940                 


Arg Val Phe Thr His Asp Leu Leu Ser Gln Arg His Gly Asp Leu Phe 
945                 950                 955                 960 


Ser Ala Val Ile Pro Pro Gln Ser Ile Ser Met Arg Cys Ala Glu Pro 
                965                 970                 975     


Lys Leu Arg Lys Ala Ile Thr Thr Gly Asn Ala Thr Tyr Leu Gly Trp 
            980                 985                 990         


Val Val Val Gly Asp Glu Leu Glu  Ile Asn Val Asp Ser  Phe Thr Lys 
        995                 1000                 1005             


Tyr Ala  Ile Gly Arg Phe Leu  Glu Asp Phe Pro Asn  Thr Thr Arg 
    1010                 1015                 1020             


Trp Arg  Ile Cys Gly Tyr Asp  Thr Asn Ser Lys Leu  Thr Leu Lys 
    1025                 1030                 1035             


Pro Ile  Val Leu Ala Ala Glu  Gly Leu Glu Asn Pro  Ser Ser Ala 
    1040                 1045                 1050             


Val Asn  Glu Ile Val Glu Leu  Lys Gly Trp Arg Val  Ala Ile Asn 
    1055                 1060                 1065             


Val Leu  Thr Lys Val His Pro  Thr Val Val Arg Arg  Asp Ala Leu 
    1070                 1075                 1080             


Gly Arg  Pro Arg Tyr Ser Ser  Arg Ser Asn Leu Pro  Thr Ser Trp 
    1085                 1090                 1095             


Thr Ile  Glu 
    1100     


<210> 52
<211> 1144
<212> PRT
<213> Actinomyces sp.


<220>
<223> Actinomyces sp. ICM47

<400> 52
Met Ser Met Ile Asp Ser Ser Glu Asn Val Pro Gly Ile Arg Tyr Arg 
1               5                   10                  15      


Val Gly Ile Asp Val Gly Leu Lys Ser Ile Gly Phe Cys Ala Val Glu 
            20                  25                  30          


Val Asp Arg Asn Asp Gln Pro Val Arg Met Leu Asn Ser Met Val Phe 
        35                  40                  45              


Ile His Asp Ala Gly Val Asp Pro Asn Glu Asn Lys Ala Ala Lys Ser 
    50                  55                  60                  


Arg Lys Leu Thr Ala Gly Val Ala Arg Arg Thr Arg Arg Leu Tyr Arg 
65                  70                  75                  80  


Thr Arg His Gln Arg Leu Val Asn Leu Asp Arg Val Leu Ser Lys Glu 
                85                  90                  95      


Phe Gly Trp Pro Leu Pro Asp Leu Thr Ser Phe Lys Asp Pro Arg Glu 
            100                 105                 110         


Pro Trp His Val Arg Ala Gly Leu Leu Glu Gly Tyr Ile Ala Asp Asp 
        115                 120                 125             


Glu Lys Arg Lys Glu Ala Leu Ser Ile Ala Leu Arg His Ile Ala Arg 
    130                 135                 140                 


His Arg Gly Trp Arg Asn Pro Tyr Ala Lys Val Glu Thr Leu Leu Gln 
145                 150                 155                 160 


Pro Ser Glu Pro Ser Asp Phe Leu Lys Gly Leu Asn Asp Arg Ile Ser 
                165                 170                 175     


Glu Glu Leu Gly Arg Ala Phe Pro Ala Asp Ala Thr Pro Gly Gln Leu 
            180                 185                 190         


Val Asp Thr Tyr Leu Ala His Pro Asp Tyr Val Gly Arg Ala Gly Thr 
        195                 200                 205             


Pro Lys Leu Arg Gly Pro Gln Gly Ile Leu Ala Gly Lys Leu His Gln 
    210                 215                 220                 


Ser Asp Asn Ala Gln Glu Ile Arg Gly Ile Cys Asp Val Gln Arg Ile 
225                 230                 235                 240 


Glu Pro Ala Glu Arg Asp Arg Leu Ile Arg Val Val Phe Glu Ala Lys 
                245                 250                 255     


Ser Pro Lys Gly Ser Ala Lys Glu Arg Gly Leu Val Gly Tyr Asp Glu 
            260                 265                 270         


Leu Pro Gly Gln Gly Arg His Val Arg Ala Glu Lys Ala His Pro Ala 
        275                 280                 285             


Phe Gln Leu Phe Arg Met Val Ser Val Leu Ala Asn Leu Arg Ile Arg 
    290                 295                 300                 


Glu Gly Arg Glu Glu Arg Pro Leu Thr Pro Asp Glu Leu Glu Asp Leu 
305                 310                 315                 320 


Val Asp Phe Ile Asn Gln Val Ser Leu Lys Gln Glu Val Thr Trp Gln 
                325                 330                 335     


Asp Leu Ala Asp Lys Leu Arg Ile Glu Arg Ala Asp Leu Arg Gly Thr 
            340                 345                 350         


Ala Lys Ala Ser Phe Asp Gly Ser Pro Val Leu Arg Asn Pro Pro Thr 
        355                 360                 365             


Asp Val Thr Thr Glu Lys Ile Met Ala Cys Lys Val Lys Trp Leu Lys 
    370                 375                 380                 


Glu Trp Trp Lys Glu Ala Asp Asp Glu Gln Arg Gly Tyr Met Val Asp 
385                 390                 395                 400 


Ala Phe Ser Asn Ser Gly Gly Ser Glu Asp Gly Thr Asp Val Asn Asp 
                405                 410                 415     


Glu Val Ala Glu Leu Leu Glu Gln Ala Thr Glu Asp Asp Gln Leu Glu 
            420                 425                 430         


Phe Glu Lys Ile Ser Leu Pro Gln Gly Arg Ala Ala Tyr Ser Leu Asp 
        435                 440                 445             


Ser Leu Arg Arg Leu Thr Asp Arg Met Leu Arg Asp Gly Val Asp Leu 
    450                 455                 460                 


His Thr Ala Arg Arg Leu Glu Phe Asn Val Gly Asp Asp Trp Lys Pro 
465                 470                 475                 480 


Ala Val Glu Pro Ile Gly Ala Pro Thr Gly Asn Pro Ala Val Asp Arg 
                485                 490                 495     


Val Leu Lys Gln Val Ser Arg Trp Leu His Ala Ala Thr Glu Arg Trp 
            500                 505                 510         


Gly Glu Pro Thr Val Ile Asn Ile Glu His Ala Arg Asp Gly Leu Gly 
        515                 520                 525             


Ser Glu Arg Val Ala Arg Glu Leu Met Arg Glu Asn Glu Lys Arg Arg 
    530                 535                 540                 


Lys Ala Asn Ala Ser Ala Val Ala Glu Met Ala Ala Lys Leu Lys Leu 
545                 550                 555                 560 


Ser Gly Lys Val His Arg Ser Asp Gln Ile Arg Tyr Phe Ala Leu Gln 
                565                 570                 575     


Arg Gln Asn Cys Gln Cys Leu Tyr Cys Gly Ala Pro Ile Thr Tyr Thr 
            580                 585                 590         


Thr Ala Glu Met Asp His Ile Val Pro Arg Ala Asp Gly Ser Ser Thr 
        595                 600                 605             


Asn Asp Arg Ser Asn Leu Ala Ala Val Cys Arg Thr Cys Asn His Met 
    610                 615                 620                 


Lys Gly Lys Ile Pro Phe Ala Val Trp Ala Ser Ser Asp Lys Ala Asn 
625                 630                 635                 640 


Gln Gly Val Ser Leu Thr Gly Ala Leu Glu Arg Val Asn Met Trp Gln 
                645                 650                 655     


Arg Asp Ser Gly Met Ser Pro Arg Gln Leu Lys Gln Leu Gln Arg Glu 
            660                 665                 670         


Val Cys Ala Arg Leu Lys Ser Lys Lys Pro Asp Gln Glu Phe Asp Gly 
        675                 680                 685             


Arg Ser Met Glu Ser Val Ala Trp Met Ala Val Glu Leu Arg Thr Arg 
    690                 695                 700                 


Ile Glu Gly Phe Tyr Arg Ser Arg Asp Glu Glu Ser Val Pro Ser Val 
705                 710                 715                 720 


Gly Val Tyr Arg Gly Gln Leu Thr Ala Glu Ala Arg Arg Ala Ser Gly 
                725                 730                 735     


Phe Glu Ser Arg Val Asn Leu Ile Gly Gly Arg Gly Lys Thr Arg Phe 
            740                 745                 750         


Asp Arg Arg His His Ala Met Asp Ala Leu Val Ile Ala Leu Met Asn 
        755                 760                 765             


Pro Ser Val Ser Arg Thr Leu Ala Leu Arg Leu Asn Met Arg Asp Ala 
    770                 775                 780                 


Gln Arg Leu Thr Gly Val Glu Glu Thr Trp Lys His Phe Tyr Gly Lys 
785                 790                 795                 800 


Pro Gly Glu Ala Ser Lys Arg Phe Glu Ser Trp Arg Glu Ser Met Leu 
                805                 810                 815     


Arg Gly Val Glu Leu Phe Asn Ile Ala Leu Ser Asp Asn Ala Ile Pro 
            820                 825                 830         


Phe Val Glu Asn Ile Arg Leu Arg Val Gly Ser Ser Val Ile His Asp 
        835                 840                 845             


Ala Thr Val His Ser Phe Cys Pro Pro Lys Thr Pro Asp Gly Lys Gln 
    850                 855                 860                 


Ile Ile Thr Lys Gly Tyr Gly Glu Gln His Ser Leu Gly Ser Ala Met 
865                 870                 875                 880 


Pro Val Glu Leu Ile Asp Arg Ala Glu Thr Pro Ala Leu Trp Thr Ala 
                885                 890                 895     


Leu Thr Arg Cys Pro Asp Phe Asp Pro Lys Lys Gly Leu Pro Glu Asn 
            900                 905                 910         


Pro Gln Arg Thr Ile Ser Val Asn Gly Thr Arg Val Gly Pro Thr Glu 
        915                 920                 925             


Leu Val Asn Phe Phe Glu Phe Ser Lys Ser Gly Pro Lys Ala Cys Leu 
    930                 935                 940                 


Lys Val Arg Gly Gly Tyr Val Asp Leu Ser Gly Ala Ile His His Ala 
945                 950                 955                 960 


Arg Ile Tyr Arg Ile Ala Gly Lys Lys Thr Ala Tyr Ala Met Ile Arg 
                965                 970                 975     


Val Phe Gln Val Asp Leu Leu Arg Leu Lys Asp His Asp Val Phe Thr 
            980                 985                 990         


Thr Pro Leu Lys Pro Ser Thr Ile  Ser Met Arg Thr Ala  Glu Pro Lys 
        995                 1000                 1005             


Ile Arg  Glu Ala Leu Ala Asn  Gly Thr Ala Thr Gln  Ile Gly Trp 
    1010                 1015                 1020             


Leu Val  Glu Gly Asp Glu Leu  Val Ile Asp Thr Ser  Lys Tyr Ser 
    1025                 1030                 1035             


Gly Gly  Phe Ile Gly Glu Val  Leu Ala Arg Tyr Pro  Glu Ala Thr 
    1040                 1045                 1050             


Ser Trp  Arg Val Ala Gly Phe  Met Thr Pro Ala Lys  Leu Arg Ile 
    1055                 1060                 1065             


Lys Pro  Ile Leu Leu Ser Lys  Glu Gly Phe Val Asp  Glu Thr Gln 
    1070                 1075                 1080             


Ala Ala  Leu Leu Gly Val Glu  Val Thr Ser Glu Ala  Ile Gln Lys 
    1085                 1090                 1095             


Thr Val  Asp Arg Pro Gly Trp  Leu Pro Ala Val Asn  Val Leu Phe 
    1100                 1105                 1110             


Gly Ala  Gly Gly Val Arg Val  Ile Arg Arg Asn Cys  Leu Gly Glu 
    1115                 1120                 1125             


Glu Arg  Tyr His Ser Ser Ala  Ser Leu Pro Val Ser  Met Thr Leu 
    1130                 1135                 1140             


Glu 
    


<210> 53
<211> 1095
<212> PRT
<213> Actinomyces sp.


<220>
<223> Actinomyces sp. oral taxon 175 str. F0384

<400> 53
Met Pro Ala His His Leu Arg Val Gly Ile Asp Val Gly Thr His Ser 
1               5                   10                  15      


Val Gly Leu Ala Thr Leu Arg Val Asp Asp Gln Gly Thr Pro Ile Glu 
            20                  25                  30          


Leu Leu Ser Ala Leu Ser His Ile His Asp Ser Gly Ile Gly Lys Glu 
        35                  40                  45              


Gly Gln Lys Asp His Asp Thr Arg Lys Lys Leu Ser Gly Val Ala Arg 
    50                  55                  60                  


Arg Thr Arg His Leu Leu Arg Asn Arg Arg Glu Arg Leu Gln Gln Leu 
65                  70                  75                  80  


Asp Lys Val Leu Val Asp Leu Gly Phe Pro Ile Pro Lys Pro Glu Glu 
                85                  90                  95      


Tyr Pro Asp Leu Ser Glu Arg Thr Asp Pro Tyr Arg Val Trp Arg Val 
            100                 105                 110         


Arg Ala Arg Leu Val Glu Glu Thr Leu Pro Glu Glu Leu Arg Gly Pro 
        115                 120                 125             


Ala Ile Ser Met Ala Val Arg His Ile Ala Arg His Arg Gly Trp Arg 
    130                 135                 140                 


Asn Pro Tyr Ser Lys Val Glu Ser Leu Leu Ser Pro Ala Glu Glu Ser 
145                 150                 155                 160 


Ser Phe Met Lys Ala Leu Arg Lys Arg Ile Met Thr Lys Thr Gly Glu 
                165                 170                 175     


Val Leu Asp Asp Asp Ile Thr Pro Gly Gln Ala Met Ala Gln Val Ala 
            180                 185                 190         


Leu Thr His Lys Ile Tyr Met Arg Gly Pro Glu Gly Ile Leu Gly Lys 
        195                 200                 205             


Leu His Gln Ser Asp Asn Ala Asn Glu Ile Arg Lys Ile Cys Ala Arg 
    210                 215                 220                 


Gln Gly Ile Ser Ser Asp Val Cys Lys Gln Leu Leu Arg Ala Val Phe 
225                 230                 235                 240 


Lys Ala Glu Ser Pro Arg Gly Ser Ala Val Ser Arg Val Ala Pro Asp 
                245                 250                 255     


Pro Leu Pro Gly Gln Gly Ser Phe Arg Arg Ala Pro Lys Cys Asp Pro 
            260                 265                 270         


Glu Phe Gln Arg Phe Arg Ile Ile Ser Ile Val Ala Asn Leu Arg Ile 
        275                 280                 285             


Ser Glu Thr Lys Gly Glu Asn Arg Pro Leu Thr Val Asp Glu Arg Arg 
    290                 295                 300                 


Gln Val Val Ala Phe Leu Met Glu Asp Ser Gln Ala Asp Leu Thr Trp 
305                 310                 315                 320 


Val Asp Val Ala Glu Lys Leu Arg Val Ser Arg Gln Ala Leu Arg Gly 
                325                 330                 335     


Thr Ala Met Leu Thr Ala Asp Gly Glu Arg Ser Ala Ala Gln Pro Pro 
            340                 345                 350         


Ile Asp Val Thr Asp Gln Ile Met Arg Lys Thr Lys Ile Ser Ala Leu 
        355                 360                 365             


Lys Thr Trp Trp Asp Lys Ala Asp Ala Glu Arg Arg Gly Ala Met Val 
    370                 375                 380                 


Arg Tyr Leu Tyr Glu Gly Leu Glu Asp Ser Glu Cys Ala Glu Val Ile 
385                 390                 395                 400 


Ala Lys Leu Pro Glu Lys Asp His Ala Lys Leu Asp Ser Leu His Leu 
                405                 410                 415     


Pro Ala Gly Arg Ala Ala Tyr Ser Arg Glu Ser Leu Thr Ala Leu Ser 
            420                 425                 430         


Asp His Met Leu Glu Thr Thr Asn Asp Leu His Glu Ala Arg Lys Arg 
        435                 440                 445             


Leu Phe Gly Val Asp Asp Ser Trp Ala Pro Pro Ala Glu Pro Val Gly 
    450                 455                 460                 


Ala Pro Val Gly Asn Pro Ser Val Asp Arg Thr Leu Lys Ile Val Ala 
465                 470                 475                 480 


Arg Tyr Leu Ser Ala Val Glu Ser Ile Trp Gly Thr Pro Glu Val Ile 
                485                 490                 495     


His Val Glu His Val Arg Asp Gly Phe Thr Ser Glu Arg Thr Ala Glu 
            500                 505                 510         


Glu Arg Asp Lys Ala Asn Arg Ser Arg His Asn Asp Asn Gln Lys Ala 
        515                 520                 525             


Ile Glu Lys Ile Gln His Asp Tyr Gly Lys Glu Gly Tyr Ile Ser Arg 
    530                 535                 540                 


Gly Asp Ile Val Arg Phe His Ala Leu Lys Leu Gln Gly Ser Ala Cys 
545                 550                 555                 560 


Leu Tyr Cys Gly Thr Thr Ile Gly Tyr His Thr Cys Gln Leu Asp His 
                565                 570                 575     


Ile Val Pro Gln Ala Gly Pro Gly Ser Asn Asn Arg Arg Gly Asn Leu 
            580                 585                 590         


Val Ala Val Cys Glu Arg Cys Asn His Ser Lys Ser Asn Thr Pro Phe 
        595                 600                 605             


Ala Val Trp Ala Gln Lys Cys Gly Ile Pro His Val Gly Val Lys Glu 
    610                 615                 620                 


Ala Ile Ser Arg Val Asn Gly Trp Val Glu His Asn His Ser Thr Ser 
625                 630                 635                 640 


Ser Gly Asp Leu Thr Arg Leu Lys Lys Glu Val Ile Ala Arg Leu Arg 
                645                 650                 655     


Arg Thr Gln Lys Asp Pro Glu Ile Asp Glu Arg Ser Met Glu Ser Val 
            660                 665                 670         


Ala Trp Met Ala Asn Glu Leu His His Arg Ile Ala Ala Ala Tyr Pro 
        675                 680                 685             


Glu Thr Thr Val Met Val Tyr Arg Gly Ser Ile Thr Ala Ala Ala Arg 
    690                 695                 700                 


Lys Ala Ala Ser Ile Glu Ser Arg Ile Asn Leu Ile Gly Glu Lys Gly 
705                 710                 715                 720 


Arg Lys Asp Arg Leu Asp Arg Arg His His Ala Val Asp Ala Ser Val 
                725                 730                 735     


Val Ala Leu Met Glu Pro Ser Val Ala Lys Thr Leu Ala Glu Arg Ser 
            740                 745                 750         


Ser Leu Arg Gly Glu Gln Arg Leu Thr Gly Gln Glu Gln Thr Trp Lys 
        755                 760                 765             


Gln Tyr Thr Gly Leu Thr Val Gly Ala Arg Glu Arg Phe Glu Ala Trp 
    770                 775                 780                 


Arg Gly His Met His Arg Leu Thr Glu Leu Phe Asn Glu Ser Leu Ala 
785                 790                 795                 800 


Ala Asp Glu Val Tyr Val Thr Gln Asn Ile Arg Leu Arg Leu Ser Asp 
                805                 810                 815     


Gly Ser Ala His Thr Val Lys Ala Ser Lys Leu Val Ser His Arg Leu 
            820                 825                 830         


Gly Asp Gly Leu Thr Val Gln Gln Ile Asp Arg Ala Cys Thr Pro Ala 
        835                 840                 845             


Leu Trp Cys Ala Leu Thr Arg Glu Ile Asp Phe Asp Glu Lys Asn Gly 
    850                 855                 860                 


Leu Pro Ala Arg Glu Asp Arg Val Ile Arg Val His Gly Gln Glu Ile 
865                 870                 875                 880 


Ser Ser Ala Asp Cys Ile Gln Val Phe Ser Lys Arg Lys Lys Thr Lys 
                885                 890                 895     


Ser Asp Arg Asp Glu Ala Pro Phe Gly Ala Ile Ala Val Arg Gly Gly 
            900                 905                 910         


Phe Val Glu Ile Gly Ser Ser Ile His His Ala Arg Ile Tyr Arg Ile 
        915                 920                 925             


Glu Gly Glu Lys Pro Ala Tyr Ala Met Leu Arg Val Phe Thr His Asp 
    930                 935                 940                 


Leu Leu Ser Gln Arg His Gly Asp Leu Phe Ser Ala Val Ile Pro Pro 
945                 950                 955                 960 


Gln Ser Ile Ser Met Arg Cys Ala Ala Thr Glu Leu Arg Gln Ala Ile 
                965                 970                 975     


Ser Glu Gly Arg Ala Thr Tyr Leu Gly Trp Ile Val Ser Gly Asp Glu 
            980                 985                 990         


Leu His Ile Pro Val Glu Thr Phe  Thr Thr His Lys Ile  Gly Ser Phe 
        995                 1000                 1005             


Leu Lys  Asp Tyr Pro Asn Thr  Thr Arg Trp Arg Ile  Cys Gly Tyr 
    1010                 1015                 1020             


Asp Ser  Glu Thr Met Leu Ile  Leu Lys Pro Arg Ile  Leu Ser Ala 
    1025                 1030                 1035             


Glu Gly  Leu Asn Asn Ser Ser  Asp Ile Ala Glu Tyr  Val Ile Lys 
    1040                 1045                 1050             


Asn Lys  Gly Trp Arg Val Ala  Ile Asn Lys Leu Ala  Lys Val His 
    1055                 1060                 1065             


Pro Thr  Val Val Arg Arg Asp  Ala Leu Gly Arg Pro  Arg His Ser 
    1070                 1075                 1080             


Ser Arg  Ser Asn Leu Pro Val  Thr Trp Ser Ile Glu  
    1085                 1090                 1095 


<210> 54
<211> 1181
<212> PRT
<213> Actinomyces sp.


<220>
<223> Actinomyces sp. oral taxon 180 str. F0310

<400> 54
Met Leu His Cys Ile Ala Val Ile Arg Val Pro Pro Ser Glu Glu Pro 
1               5                   10                  15      


Gly Phe Phe Glu Thr His Ala Asp Ser Cys Ala Leu Cys His His Gly 
            20                  25                  30          


Cys Met Thr Tyr Ala Ala Asn Asp Lys Ala Ile Arg Tyr Arg Val Gly 
        35                  40                  45              


Ile Asp Val Gly Leu Arg Ser Ile Gly Phe Cys Ala Val Glu Val Asp 
    50                  55                  60                  


Asp Glu Asp His Pro Ile Arg Ile Leu Asn Ser Val Val His Val His 
65                  70                  75                  80  


Asp Ala Gly Thr Gly Gly Pro Gly Glu Thr Glu Ser Leu Arg Lys Arg 
                85                  90                  95      


Ser Gly Val Ala Ala Arg Ala Arg Arg Arg Gly Arg Ala Glu Lys Gln 
            100                 105                 110         


Arg Leu Lys Lys Leu Asp Val Leu Leu Glu Glu Leu Gly Trp Gly Val 
        115                 120                 125             


Ser Ser Asn Glu Leu Leu Asp Ser His Ala Pro Trp His Ile Arg Lys 
    130                 135                 140                 


Arg Leu Val Ser Glu Tyr Ile Glu Asp Glu Thr Glu Arg Arg Gln Cys 
145                 150                 155                 160 


Leu Ser Val Ala Met Ala His Ile Ala Arg His Arg Gly Trp Arg Asn 
                165                 170                 175     


Ser Phe Ser Lys Val Asp Thr Leu Leu Leu Glu Gln Ala Pro Ser Asp 
            180                 185                 190         


Arg Met Gln Gly Leu Lys Glu Arg Val Glu Asp Arg Thr Gly Leu Gln 
        195                 200                 205             


Phe Ser Glu Glu Val Thr Gln Gly Glu Leu Val Ala Thr Leu Leu Glu 
    210                 215                 220                 


His Asp Gly Asp Val Thr Ile Arg Gly Phe Val Arg Lys Gly Gly Lys 
225                 230                 235                 240 


Ala Thr Lys Val His Gly Val Leu Glu Gly Lys Tyr Met Gln Ser Asp 
                245                 250                 255     


Leu Val Ala Glu Leu Arg Gln Ile Cys Arg Thr Gln Arg Val Ser Glu 
            260                 265                 270         


Thr Thr Phe Glu Lys Leu Val Leu Ser Ile Phe His Ser Lys Glu Pro 
        275                 280                 285             


Ala Pro Ser Ala Ala Arg Gln Arg Glu Arg Val Gly Leu Asp Glu Leu 
    290                 295                 300                 


Gln Leu Ala Leu Asp Pro Ala Ala Lys Gln Pro Arg Ala Glu Arg Ala 
305                 310                 315                 320 


His Pro Ala Phe Gln Lys Phe Lys Val Val Ala Thr Leu Ala Asn Met 
                325                 330                 335     


Arg Ile Arg Glu Gln Ser Ala Gly Glu Arg Ser Leu Thr Ser Glu Glu 
            340                 345                 350         


Leu Asn Arg Val Ala Arg Tyr Leu Leu Asn His Thr Glu Ser Glu Ser 
        355                 360                 365             


Pro Thr Trp Asp Asp Val Ala Arg Lys Leu Glu Val Pro Arg His Arg 
    370                 375                 380                 


Leu Arg Gly Ser Ser Arg Ala Ser Leu Glu Thr Gly Gly Gly Leu Thr 
385                 390                 395                 400 


Tyr Pro Pro Val Asp Asp Thr Thr Val Arg Val Met Ser Ala Glu Val 
                405                 410                 415     


Asp Trp Leu Ala Asp Trp Trp Asp Cys Ala Asn Asp Glu Ser Arg Gly 
            420                 425                 430         


His Met Ile Asp Ala Ile Ser Asn Gly Cys Gly Ser Glu Pro Asp Asp 
        435                 440                 445             


Val Glu Asp Glu Glu Val Asn Glu Leu Ile Ser Ser Ala Thr Ala Glu 
    450                 455                 460                 


Asp Met Leu Lys Leu Glu Leu Leu Ala Lys Lys Leu Pro Ser Gly Arg 
465                 470                 475                 480 


Val Ala Tyr Ser Leu Lys Thr Leu Arg Glu Val Thr Ala Ala Ile Leu 
                485                 490                 495     


Glu Thr Gly Asp Asp Leu Ser Gln Ala Ile Thr Arg Leu Tyr Gly Val 
            500                 505                 510         


Asp Pro Gly Trp Val Pro Thr Pro Ala Pro Ile Glu Ala Pro Val Gly 
        515                 520                 525             


Asn Pro Ser Val Asp Arg Val Leu Lys Gln Val Ala Arg Trp Leu Lys 
    530                 535                 540                 


Phe Ala Ser Lys Arg Trp Gly Val Pro Gln Thr Val Asn Ile Glu His 
545                 550                 555                 560 


Thr Arg Glu Gly Leu Lys Ser Ala Ser Leu Leu Glu Glu Glu Arg Glu 
                565                 570                 575     


Arg Trp Glu Arg Phe Glu Ala Arg Arg Glu Ile Arg Gln Lys Glu Met 
            580                 585                 590         


Tyr Lys Arg Leu Gly Ile Ser Gly Pro Phe Arg Arg Ser Asp Gln Val 
        595                 600                 605             


Arg Tyr Glu Ile Leu Asp Leu Gln Asp Cys Ala Cys Leu Tyr Cys Gly 
    610                 615                 620                 


Asn Glu Ile Asn Phe Gln Thr Phe Glu Val Asp His Ile Ile Pro Arg 
625                 630                 635                 640 


Val Asp Ala Ser Ser Asp Ser Arg Arg Thr Asn Leu Ala Ala Val Cys 
                645                 650                 655     


His Ser Cys Asn Ser Ala Lys Gly Gly Leu Ala Phe Gly Gln Trp Val 
            660                 665                 670         


Lys Arg Gly Asp Cys Pro Ser Gly Val Ser Leu Glu Asn Ala Ile Lys 
        675                 680                 685             


Arg Val Arg Ser Trp Ser Lys Asp Arg Leu Gly Leu Thr Glu Lys Ala 
    690                 695                 700                 


Met Gly Lys Arg Lys Ser Glu Val Ile Ser Arg Leu Lys Thr Glu Met 
705                 710                 715                 720 


Pro Tyr Glu Glu Phe Asp Gly Arg Ser Met Glu Ser Val Ala Trp Met 
                725                 730                 735     


Ala Ile Glu Leu Lys Lys Arg Ile Glu Gly Tyr Phe Asn Ser Asp Arg 
            740                 745                 750         


Pro Glu Gly Cys Ala Ala Val Gln Val Asn Ala Tyr Ser Gly Arg Leu 
        755                 760                 765             


Thr Ala Cys Ala Arg Arg Ala Ala His Val Asp Lys Arg Val Arg Leu 
    770                 775                 780                 


Ile Arg Leu Lys Gly Asp Asp Gly His His Lys Asn Arg Phe Asp Arg 
785                 790                 795                 800 


Arg Asn His Ala Met Asp Ala Leu Val Ile Ala Leu Met Thr Pro Ala 
                805                 810                 815     


Ile Ala Arg Thr Ile Ala Val Arg Glu Asp Arg Arg Glu Ala Gln Gln 
            820                 825                 830         


Leu Thr Arg Ala Phe Glu Ser Trp Lys Asn Phe Leu Gly Ser Glu Glu 
        835                 840                 845             


Arg Met Gln Asp Arg Trp Glu Ser Trp Ile Gly Asp Val Glu Tyr Ala 
    850                 855                 860                 


Cys Asp Arg Leu Asn Glu Leu Ile Asp Ala Asp Lys Ile Pro Val Thr 
865                 870                 875                 880 


Glu Asn Leu Arg Leu Arg Asn Ser Gly Lys Leu His Ala Asp Gln Pro 
                885                 890                 895     


Glu Ser Leu Lys Lys Ala Arg Arg Gly Ser Lys Arg Pro Arg Pro Gln 
            900                 905                 910         


Arg Tyr Val Leu Gly Asp Ala Leu Pro Ala Asp Val Ile Asn Arg Val 
        915                 920                 925             


Thr Asp Pro Gly Leu Trp Thr Ala Leu Val Arg Ala Pro Gly Phe Asp 
    930                 935                 940                 


Ser Gln Leu Gly Leu Pro Ala Asp Leu Asn Arg Gly Leu Lys Leu Arg 
945                 950                 955                 960 


Gly Lys Arg Ile Ser Ala Asp Phe Pro Ile Asp Tyr Phe Pro Thr Asp 
                965                 970                 975     


Ser Pro Ala Leu Ala Val Gln Gly Gly Tyr Val Gly Leu Glu Phe His 
            980                 985                 990         


His Ala Arg Leu Tyr Arg Ile Ile  Gly Pro Lys Glu Lys  Val Lys Tyr 
        995                 1000                 1005             


Ala Leu  Leu Arg Val Cys Ala  Ile Asp Leu Cys Gly  Ile Asp Cys 
    1010                 1015                 1020             


Asp Asp  Leu Phe Glu Val Glu  Leu Lys Pro Ser Ser  Ile Ser Met 
    1025                 1030                 1035             


Arg Thr  Ala Asp Ala Lys Leu  Lys Glu Ala Met Gly  Asn Gly Ser 
    1040                 1045                 1050             


Ala Lys  Gln Ile Gly Trp Leu  Val Leu Gly Asp Glu  Ile Gln Ile 
    1055                 1060                 1065             


Asp Pro  Thr Lys Phe Pro Lys  Gln Ser Ile Gly Lys  Phe Leu Lys 
    1070                 1075                 1080             


Glu Cys  Gly Pro Val Ser Ser  Trp Arg Val Ser Ala  Leu Asp Thr 
    1085                 1090                 1095             


Pro Ser  Lys Ile Thr Leu Lys  Pro Arg Leu Leu Ser  Asn Glu Pro 
    1100                 1105                 1110             


Leu Leu  Lys Thr Ser Arg Val  Gly Gly His Glu Ser  Asp Leu Val 
    1115                 1120                 1125             


Val Ala  Glu Cys Val Glu Lys  Ile Met Lys Lys Thr  Gly Trp Val 
    1130                 1135                 1140             


Val Glu  Ile Asn Ala Leu Cys  Gln Ser Gly Leu Ile  Arg Val Ile 
    1145                 1150                 1155             


Arg Arg  Asn Ala Leu Gly Glu  Val Arg Thr Ser Pro  Lys Ser Gly 
    1160                 1165                 1170             


Leu Pro  Ile Ser Leu Asn Leu  Arg 
    1175                 1180     


<210> 55
<211> 1103
<212> PRT
<213> Actinomyces sp.


<220>
<223> Actinomyces sp. oral taxon 181 str. F0379

<400> 55
Met Thr Lys Ile Asn Asp Asp Leu Arg Tyr Arg Val Gly Ile Asp Val 
1               5                   10                  15      


Gly Leu Lys Ser Ile Gly Phe Cys Ala Val Glu Val Asp Glu Asn Asp 
            20                  25                  30          


Gln Pro Leu Arg Leu Leu Asn Ser Met Val Phe Val His Asp Ala Gly 
        35                  40                  45              


Val Asp Pro Asn Glu Asn Lys Ala Ala Lys Ser Arg Lys Leu Thr Ala 
    50                  55                  60                  


Gly Val Ala Arg Arg Thr Gln Arg Gly Thr Ala Gln Asn Arg Arg Arg 
65                  70                  75                  80  


Leu Ala Glu Leu Asp Arg Ala Leu Ser Glu Glu Leu Asn Trp Pro Leu 
                85                  90                  95      


Pro Asn Leu Glu Asp Phe Glu Asp Ser Tyr Glu Pro Trp His Thr Arg 
            100                 105                 110         


Ala Glu Leu Val Glu His Tyr Ile Lys Asp Asp Ala Glu Arg Ala Glu 
        115                 120                 125             


Ala Leu Ala Ile Ala Ile Arg His Ile Ala Arg His Arg Gly Trp Arg 
    130                 135                 140                 


Asn Pro Tyr Leu Ser Val Asp Ser Leu Leu Thr Pro Gln Glu Pro Ser 
145                 150                 155                 160 


Lys Phe Leu Arg Gly Leu Asn Glu Arg Val Thr Gln Ala Leu Gly Arg 
                165                 170                 175     


Glu Phe Pro Ala Asp Ala Thr Pro Gly Gln Leu Ile Cys Ala Tyr Ile 
            180                 185                 190         


Asp Ser Pro Lys Tyr Ala Glu Thr Gln Gly Ile Arg Gly Asp Ser Gly 
        195                 200                 205             


Ile Leu Ser Gly Lys Leu His Gln Phe Asp Asn Val Gly Glu Ile Arg 
    210                 215                 220                 


Lys Ile Cys Glu Val Gln Arg Leu Asp His Asp Val Phe Lys Leu Leu 
225                 230                 235                 240 


Val Arg Lys Val Phe Phe Ala Lys Ser Pro Arg Gly Ser Ala Ala Gly 
                245                 250                 255     


Leu Val Gly His Asp Gln Ile Pro Gly Gln Gly Lys Tyr Ile Arg Ala 
            260                 265                 270         


Glu Lys Ala His Pro Asp Phe Gln Leu Phe Arg Ile Val Ala Val Leu 
        275                 280                 285             


Thr Asn Leu Arg Ile Arg Glu Gly Lys Ala Glu Arg Cys Leu Thr Pro 
    290                 295                 300                 


Asp Glu Leu Arg Gly Leu Val Asp Tyr Ile Leu Glu Val Gln Leu Lys 
305                 310                 315                 320 


Gln Gln Val Thr Trp Ala Asp Leu Ala Asp Asn Leu Gly Ile Glu Arg 
                325                 330                 335     


Thr Asp Leu Arg Gly Thr Ala Arg Ala Ser Phe Asp Gly Ser Pro Ala 
            340                 345                 350         


Leu Arg Phe Pro Pro Thr Asp Val Thr Ala Glu Lys Ile Met Ala Ser 
        355                 360                 365             


Lys Val Lys Trp Leu Lys Asp Trp Trp Asp Lys Ala Asp Ser Glu Arg 
    370                 375                 380                 


Arg Gly Phe Met Val Asp Ala Leu Ser Asn Ser Gly Gly Ser Thr Gly 
385                 390                 395                 400 


Asp Asn Asp Ile Asp Asp Glu Val Ala Ala Leu Leu Glu Ala Ala Thr 
                405                 410                 415     


Glu Asp Glu Gln Ala Glu Leu Glu Lys Ile Gln Leu Pro Gln Gly Arg 
            420                 425                 430         


Ala Ala Tyr Ser Leu Asp Ser Leu Arg Arg Leu Thr Lys Arg Met Leu 
        435                 440                 445             


Glu Glu Gly Val Asp Leu His Thr Ala Arg Lys Glu Glu Phe Asn Val 
    450                 455                 460                 


Asp Asp Asp Trp Arg Pro Glu Pro Glu Pro Ile Glu Ala Pro Val Gly 
465                 470                 475                 480 


Asn Pro Ala Val Asp Arg Val Leu Lys Gln Val Ala Arg Trp Leu Asn 
                485                 490                 495     


Met Ala Thr Asp Arg Trp Gly Val Pro Asp Val Ile Asn Ile Glu His 
            500                 505                 510         


Thr Arg Asp Gly Leu Gly Ser Glu Lys Val Ala Arg Glu Leu Leu Arg 
        515                 520                 525             


Glu Ser Gln Lys Arg Gln Asp Leu Asn Gln Lys Asp Met Asp Lys Met 
    530                 535                 540                 


Ile Arg Glu Leu Gly Ile Ser Gly Lys Ala Arg Arg Ser Ser Leu Ile 
545                 550                 555                 560 


Lys Tyr Gln Ala Ile Gln Arg Gln Asn Ser Met Cys Leu Tyr Cys Gly 
                565                 570                 575     


Thr Glu Ile Gly Phe Glu Thr Ala Glu Met Asp His Ile Val Pro Arg 
            580                 585                 590         


Ala Leu Ser Gly Ser Thr Asn Asp Arg Ser Asn Leu Ala Ala Val Cys 
        595                 600                 605             


Arg Ala Cys Asn His Gln Lys Gly Ala Val Pro Phe Ala Val Trp Ala 
    610                 615                 620                 


Thr Ser Gly Glu Ala His Ala Gly Val Ser Leu Glu Asp Ala Ile Lys 
625                 630                 635                 640 


Arg Val Arg Leu Trp Gln Lys Gly Pro Gly Met Ser Pro Lys Gln His 
                645                 650                 655     


Lys Ala Phe Gln Asn Glu Val Ile Ser Arg Leu Lys Ser Arg Lys Pro 
            660                 665                 670         


Asp Glu Glu Phe Asp Gly Arg Ser Met Glu Ser Val Ala Trp Met Ala 
        675                 680                 685             


Val Glu Leu Arg Thr Arg Ile Asp Gly Tyr Tyr Arg Lys Val Asn Ser 
    690                 695                 700                 


Asp Ser Val Pro Lys Val Gly Ile Tyr Arg Gly Gln Leu Thr Ala Glu 
705                 710                 715                 720 


Ala Arg Lys Ala Ser Gly Phe Glu Asn Arg Val Asn Leu Ile Gly Gly 
                725                 730                 735     


Lys Gly Lys Thr Arg Phe Asp Arg Arg His His Ala Met Asp Ala Leu 
            740                 745                 750         


Val Ile Ala Met Met Asn Gln Ser Val Ser Gln Thr Leu Ala Leu Arg 
        755                 760                 765             


Val Asn Met Arg Glu Ser Gln Arg Ile Thr Gly Gln Glu Glu Thr Trp 
    770                 775                 780                 


Lys Asn Phe Tyr Gly Lys Pro Gly Gln Ala Ser Glu Arg Phe Glu Lys 
785                 790                 795                 800 


Trp Arg Glu Gly Met Leu Arg Ala Val Glu Leu Phe Asn Ile Glu Leu 
                805                 810                 815     


Ala Lys Asn Ala Ile Pro Phe His Glu Asn Val Arg Leu Arg Val Gly 
            820                 825                 830         


Ser Ser Lys Val His Asp Asp Thr Val Arg Lys Phe Ile His Ala Lys 
        835                 840                 845             


Leu Gly Glu Ala Leu Ser Val Ala Met Ile Asp Cys Ala Glu Thr Pro 
    850                 855                 860                 


Ala Leu Trp Thr Ala Leu Thr Arg Leu Pro Asp Phe Asp Pro Lys Asp 
865                 870                 875                 880 


Gly Leu Pro Glu Asp Leu Ser Arg Glu Ile Tyr Ile His Ser Arg Lys 
                885                 890                 895     


Ile Thr Ala Asp Glu Gln Leu Asn Phe Phe Asn Ser Pro Ser Ala Cys 
            900                 905                 910         


Leu Lys Val Arg Gly Gly Tyr Val Glu Ile Gly Ser Ser Ile His His 
        915                 920                 925             


Ala Arg Val Tyr Arg Ile Asp Gly Lys Lys Thr Thr Tyr Ser Met Val 
    930                 935                 940                 


Arg Val Phe Ala Thr Asp Leu Val Lys Met Thr His Glu Asp Val Phe 
945                 950                 955                 960 


Thr Thr Pro Leu Lys Pro Ser Thr Ile Ser Met Arg Thr Ala Asp Pro 
                965                 970                 975     


Lys Ile Arg Lys Ala Leu Ala Asp Gly Thr Ala Thr Gln Ile Gly Trp 
            980                 985                 990         


Leu Val Glu Gly Asp Glu Leu Gln  Leu Glu Thr Asp Lys  Tyr Ser Gly 
        995                 1000                 1005             


Gly Leu  Ile Gly Glu Val Leu  Ala Glu Tyr Pro Gln  Leu Thr Ser 
    1010                 1015                 1020             


Trp Arg  Val Ala Gly Phe Tyr  Gly Val Thr Gln Leu  Arg Leu Arg 
    1025                 1030                 1035             


Pro Tyr  Met Leu Ala Ala Glu  Gly Ile Pro Ser Asp  Ala Ser Glu 
    1040                 1045                 1050             


Ser Leu  Arg Lys Val Ile Glu  Gly Lys Gly Trp Leu  Pro Ala Ile 
    1055                 1060                 1065             


Asn Ala  Leu Leu Ser Ser Gly  Cys Val Lys Val Val  Arg Arg Asn 
    1070                 1075                 1080             


Cys Leu  Gly Glu Pro Arg Phe  Asn Ala Lys Ser Ser  Leu Pro Val 
    1085                 1090                 1095             


Ser Gln  Leu Leu Arg 
    1100             


<210> 56
<211> 1120
<212> PRT
<213> Actinomyces sp.


<220>
<223> Actinomyces sp. oral taxon 848 str. F0332

<400> 56
Met Asn Ala Met Lys Gln Tyr Asn Ala Gly Ile Asp Val Gly Ile Asn 
1               5                   10                  15      


Ser Val Gly Phe Ala Ala Ile Glu Val Asp Ser Lys Gly Leu Pro Leu 
            20                  25                  30          


Asn Ile Leu Asn Asn Met Val Val Leu His Asp Ser Gly Val Asp Pro 
        35                  40                  45              


Gly Thr Ala Lys Thr Gly Ala Thr Arg Leu Ala Asn Ser Gly Thr Ala 
    50                  55                  60                  


Arg Arg Thr Arg Lys Leu Ile Ala Arg Arg Arg Lys Arg Leu Gln Lys 
65                  70                  75                  80  


Leu Asp Arg Tyr Ile Glu Val Gln Gly Trp Pro Leu Val Asp Phe Ser 
                85                  90                  95      


Ser Leu Pro Asp Pro Tyr Thr Pro Trp Lys Ile Arg Ala Lys Leu Thr 
            100                 105                 110         


Gln Asp Arg Leu Glu Gly Glu Glu Gln Gly Arg Gly Leu Ser Ile Ala 
        115                 120                 125             


Leu Arg His Met Ala Arg His Arg Gly Trp Arg Asn Pro Tyr Glu Gly 
    130                 135                 140                 


Val Glu Ser Leu His Ser Pro Lys Glu Ala Ser Lys Gln Phe Lys Asp 
145                 150                 155                 160 


Leu Lys Asp Arg Val Thr Lys Val Ser Gly Val Ile Phe Asp Glu Asp 
                165                 170                 175     


Ala Thr Pro Ala Glu Val Val Cys Asp Ile Gly Leu Ser Pro Lys Gln 
            180                 185                 190         


Arg Leu Arg Ser Ala Pro Ser Ala Lys Tyr Lys Glu Gly Ala Thr Leu 
        195                 200                 205             


Ala Asp Glu Pro Val Gly Gly Lys Ser Lys Glu Gly Leu Leu Gly Gly 
    210                 215                 220                 


Lys Leu Met Gln Ser Asp Asn Ala Asn Glu Leu Arg Lys Ile Gly Ile 
225                 230                 235                 240 


Val Gln Gly Leu Ser Asn Glu Lys Val Asn Glu Ile Ile Asp Gln Val 
                245                 250                 255     


Phe Ala Ser Glu Ser Pro Lys Gly Gln Ala Gly Lys Arg Ala Lys Lys 
            260                 265                 270         


Asp Glu Leu Pro Gly Gln Glu Gln Tyr Val Arg Ala Leu Arg Ala His 
        275                 280                 285             


Leu Ala Phe Gln Arg Phe Arg Ile Val Ala Ala Val Ala Asn Leu Arg 
    290                 295                 300                 


Ile Leu Glu Ala Glu Pro Lys His Glu Arg Leu Leu Ser Gln Ser Glu 
305                 310                 315                 320 


Lys Asp Lys Val Ile Glu Phe Leu Met Ser Ala Asp Gly Asp Asp Gly 
                325                 330                 335     


Val Thr Trp Ser Asp Val Ala Glu Glu Leu Gly Ile Glu Arg Glu Cys 
            340                 345                 350         


Leu Ser Gly Thr Ala Lys Arg Gly Ala Asp Gly Glu Arg Pro Ser Ser 
        355                 360                 365             


Phe Pro Pro Thr Asn Ser Thr Asn Ile Ser Ile Val Arg Ser Lys Val 
    370                 375                 380                 


Lys Pro Leu Ile Glu Trp Trp Arg Lys Ala Ser Asp Asp Glu Gln Ala 
385                 390                 395                 400 


Thr Leu Val Thr Ala Leu Ser Asn Ala Asp Glu Leu Thr Asp Asp Gln 
                405                 410                 415     


Pro Ser Ala Glu Thr Val Arg Gln Phe Leu Ser Ser Pro Asp Glu Gln 
            420                 425                 430         


Ser Gln Glu Lys Ile Asp Lys Ile Ser Leu Pro Lys Gly Arg Ala Ala 
        435                 440                 445             


Tyr Ser Val Asn Ser Leu Glu Arg Leu Thr Arg Arg Met Leu Lys Asp 
    450                 455                 460                 


Ser Val Asp Leu Phe Glu Ala Arg Lys Arg Glu Phe Gly Val Asp Asn 
465                 470                 475                 480 


Asn Trp Thr Pro Thr Pro Asp Ser Ile Gly Glu Pro Val Gly Asn Pro 
                485                 490                 495     


Ala Val Asp Arg Val Leu Lys Ile Val Asn Arg Trp Leu Leu Ala Val 
            500                 505                 510         


Thr Arg Lys Trp Gly Pro Pro Lys Val Val Asn Ile Glu His Val Arg 
        515                 520                 525             


Val Gly Phe Thr Ser Ala Ala Gln Thr Arg Lys Tyr Glu Glu Glu Asn 
    530                 535                 540                 


Lys Thr Asn Arg Glu Arg Asn Leu Ala Ile Leu Glu Glu Leu Arg Asp 
545                 550                 555                 560 


Lys Phe Gly Thr Ser Gly Lys Ile Arg Arg Glu Asp Ile Thr Arg Phe 
                565                 570                 575     


Ala Ala Leu Arg Arg Gln Asn Cys Gln Cys Ala Tyr Cys Gly Glu Ala 
            580                 585                 590         


Ile Thr Phe Phe Asp Cys Glu Met Asp His Ile Val Pro Arg Lys Gly 
        595                 600                 605             


Pro Gly Ser Thr Asn Thr Arg Asn Asn Leu Val Ala Ile Cys Glu Arg 
    610                 615                 620                 


Cys Asn Lys Ser Lys Ser Asn Met Pro Phe Ser Leu Trp Ala Gln Asn 
625                 630                 635                 640 


Cys Asp Ile Pro Gly Val Ser Val Glu Ala Val Ile Asp Arg Val Arg 
                645                 650                 655     


Thr Trp Ile Lys Asp Pro Glu Leu Asn Pro Lys Gln Tyr Asn Asn Phe 
            660                 665                 670         


Lys Lys Asp Val Ile Glu Arg Leu Arg Lys Thr Val Asp Asp Asp Ala 
        675                 680                 685             


Ile Asp Asn Arg Ser Ile Glu Ser Val Ala Trp Met Ala Thr Glu Leu 
    690                 695                 700                 


Ala Asp Arg Ile Gly Ser His Phe Arg Thr Ala Gly Ala Asn Thr Lys 
705                 710                 715                 720 


Val Arg Val Tyr Arg Gly Trp Leu Thr Ser Glu Ala Arg Lys Ala Ser 
                725                 730                 735     


Gly Phe Glu Gly Lys Ile Asn Leu Ile Gly Gly Arg Gly Lys Thr Arg 
            740                 745                 750         


Leu Asp Arg Arg His His Ala Met Asp Ala Ala Thr Ile Ala Leu Met 
        755                 760                 765             


Arg Gln Ser Val Ala Gln Thr Leu Val Glu Arg Ala Ser Ile Arg Glu 
    770                 775                 780                 


Ser Asp Arg Leu Arg Arg Val Val Ser Ser Ser Trp Lys Asp Tyr Arg 
785                 790                 795                 800 


Gly Ala Asp Arg Asp Lys Gln Phe Ser Tyr Gly Ser Trp Leu Asn Ser 
                805                 810                 815     


Met Asn Ala Leu Ala Glu Leu Phe Asn Arg Ala Ile Asp Ala Asp Gly 
            820                 825                 830         


Ile Pro Val Thr Gln Asn Leu Arg Leu Arg Leu Gly Asn Gly Glu Ala 
        835                 840                 845             


His Asp Ala Thr Ile Arg Ser Leu Glu Lys Lys Arg Val Gly Ala Ser 
    850                 855                 860                 


Trp Thr Ile Gly Glu Ile Asp Arg Ala Ser Thr Pro Gln Leu Trp Leu 
865                 870                 875                 880 


Ala Leu Thr Arg Gln Glu Asp Phe Asp Gln Asn Asp Gly Leu Pro Ala 
                885                 890                 895     


Asn Ala Ser Arg Glu Leu Arg Val Lys Asn His Trp Phe His Ala Glu 
            900                 905                 910         


Glu Asn Val Thr Leu Phe Pro Thr Lys Ser Ala Ala Ile Ala Val Arg 
        915                 920                 925             


Gly Gly Tyr Ala Glu Ile Gly Asn Thr Ile His His Ala Arg Leu Tyr 
    930                 935                 940                 


Lys Leu Pro Gly Lys Lys Leu Thr Tyr Gly Met Ile Arg Val Phe Ala 
945                 950                 955                 960 


Ile Asp Leu Leu Cys Ala Trp His Thr Asp Leu Phe Ser Ser Pro Leu 
                965                 970                 975     


Leu Pro Glu Ser Ile Ser Leu Arg Thr Ala Glu Thr Lys Val Arg Arg 
            980                 985                 990         


Ala Val Glu Asp Gly Ala Ala Met  Tyr Ile Gly Trp Leu  Val Asp Gly 
        995                 1000                 1005             


Asp Glu  Ile Val Leu Asp Pro  Glu Thr Lys Ala Phe  Lys Ser Asn 
    1010                 1015                 1020             


Lys Ile  Gly Glu Tyr Leu Cys  Glu Phe Pro Gly Thr  Lys Arg Trp 
    1025                 1030                 1035             


Lys Val  Asp Gly Phe Pro Asp  Lys Glu Lys Leu Arg  Leu Arg Pro 
    1040                 1045                 1050             


Leu Gln  Leu Ala Gly Glu Gly  Leu Pro Glu Asp Val  Ser Ala Gly 
    1055                 1060                 1065             


Thr Glu  Glu Ile Leu Gly Pro  Lys Gly Asn Gly Trp  Arg Val Ala 
    1070                 1075                 1080             


Ile Asn  Ala Leu Phe Lys Ser  Ser Gln Leu Val Val  Val Arg Arg 
    1085                 1090                 1095             


Thr Ala  Leu Gly Met Val Arg  Lys Leu Ser Arg Arg  His Leu Pro 
    1100                 1105                 1110             


Leu Thr  Thr Arg Leu Arg Gly  
    1115                 1120 


<210> 57
<211> 1114
<212> PRT
<213> Actinomyces turicensis


<220>
<223> Actinomyces turicensis ACS-279-V-Col4

<400> 57
Met Gln Phe His Phe Tyr Met Val Tyr Val Thr Met Lys Gly Met Asn 
1               5                   10                  15      


Asp Lys Asp Ala Ser Gln Gln Leu Arg Tyr Arg Val Gly Ile Asp Val 
            20                  25                  30          


Gly Thr His Ser Ile Gly Phe Cys Ala Val Glu Val Asp Glu Ser Gly 
        35                  40                  45              


Met Pro Ile Gln Leu Leu Asn Ser Met Val His Lys His Asp Ser Gly 
    50                  55                  60                  


Ile Asp Pro Gly Gly Asn Asp Thr Ala Thr Thr Arg Leu Ala Glu Ala 
65                  70                  75                  80  


Gly Val Ala Arg Arg Thr Arg Arg Leu Ile Arg Arg Arg Lys Lys Arg 
                85                  90                  95      


Leu Gln Glu Leu Asp Ala Phe Ile Glu Glu Cys Gly Trp Pro Leu Val 
            100                 105                 110         


Asp Leu Ala Thr Ile Thr Asp Ala Arg Ser Pro Trp Arg Ile Arg Ala 
        115                 120                 125             


His Leu Ala Thr Glu His Ile Asp Asp Glu Ala Glu Gln Gly Lys Leu 
    130                 135                 140                 


Leu Ser Ile Ala Leu Arg His Met Ala Arg His Arg Gly Trp Arg Ser 
145                 150                 155                 160 


Pro Tyr Ala Arg Ile Ser Ser Leu His Ile Gln Ala Asp Pro Ser Glu 
                165                 170                 175     


Gln Leu Lys Ala Leu Ala Gln Arg Val Ser Glu Lys Thr Gly Ile Ser 
            180                 185                 190         


Leu Thr Ala Asp Gln Thr Pro Ala Gln Leu Ile Ser Val Tyr Leu Asp 
        195                 200                 205             


Val Phe Glu Thr Gly Lys Leu Arg Gly Pro Glu Gly Ile Leu Gly Gly 
    210                 215                 220                 


Lys Leu Met Gln Ser Asp Asn Ala Asn Glu Leu Arg Arg Ile Ala Thr 
225                 230                 235                 240 


Val Gln Gly Leu Asp Asn Asp Leu Leu Lys Lys Ile Ile Gly Phe Val 
                245                 250                 255     


Phe Ala Ala Glu Ser Pro Lys Gly Ser Ala Ala Lys Arg Val Gly Lys 
            260                 265                 270         


Asp Val Leu Pro Gly Ala His Gly Leu Arg Ala Glu Lys Ala His Pro 
        275                 280                 285             


Ala Phe Gln Gln Phe Arg Ile Val Ser Ile Val Gln Asn Leu Arg Ile 
    290                 295                 300                 


Lys Glu Gly Thr Gly Leu Arg Ala Leu Thr Ser Glu Glu Thr Glu Ile 
305                 310                 315                 320 


Val Val Asp Phe Leu Asn Gln Ala Gly Leu Thr Glu Ala Pro Thr Trp 
                325                 330                 335     


Glu Glu Val Ala Asp Asn Leu Glu Ile Pro Arg Ser His Leu Lys Gly 
            340                 345                 350         


Thr Ala Thr Glu Gly Phe Asp Gly Ile Ala Pro Ser Thr Arg Pro Pro 
        355                 360                 365             


Phe Asp Val Thr Ser Gln Lys Ile Leu Asn Gly Lys Leu Lys Lys Leu 
    370                 375                 380                 


Ser Ala Trp Trp Lys Asp Ala Asp Tyr Asp His Arg Cys Ala Met Val 
385                 390                 395                 400 


Asn Ala Leu Ser Asn Val Gly Ser Asp Asp Glu Gly Ser Leu Ala Asp 
                405                 410                 415     


Asp Asp Val Arg Glu Phe Leu Ser Asp Phe Thr Asp Glu Glu Leu Glu 
            420                 425                 430         


Ala Leu Asp Lys Val Glu Leu Pro Gly Gly Arg Ala Ala Tyr Ser Val 
        435                 440                 445             


Asp Ser Leu Glu Lys Leu Thr Asn Thr Met Leu Ser Glu Gly Cys Asp 
    450                 455                 460                 


Leu His Ser Ala Arg Lys Ile Ala Phe Gly Val Asp Asp Ser Trp Thr 
465                 470                 475                 480 


Pro Pro Ala Glu Pro Ile Gly Gln Pro Val Gly Asn Pro Ala Val Asp 
                485                 490                 495     


Arg Val Leu Lys Gln Val Ala Arg Trp Ile Ser Ala Ala Thr Asn Gln 
            500                 505                 510         


Trp Gly Thr Pro Glu Ser Val Asn Ile Glu His Val Arg Asp Ala Leu 
        515                 520                 525             


Gly Ser Glu Lys Ala Ser Arg Glu Tyr Gln Arg Ser Leu Gln Thr Arg 
    530                 535                 540                 


Arg Ile Arg Asn Glu Lys Leu Phe Ala Glu Met Arg Glu Arg Leu Asp 
545                 550                 555                 560 


Ile Gly Gly Lys Pro Arg Arg Ser Glu Leu Thr Arg Tyr Leu Ala Leu 
                565                 570                 575     


Gln Arg Gln Asn Cys Gln Cys Leu Tyr Cys Gly Met Pro Ile Thr Tyr 
            580                 585                 590         


Thr Asp Ala Glu Met Asp His Ile Val Pro Arg Lys Gly Ala Ala Ser 
        595                 600                 605             


Thr Asn Thr Arg Glu Asn Phe Ala Ala Val Cys Arg Ala Cys Asn His 
    610                 615                 620                 


Gln Lys Ser Asn Leu Pro Phe Ala Val Trp Ala Glu Lys Thr Glu Arg 
625                 630                 635                 640 


Pro Gly Val Ser Val Lys Glu Ala Tyr Lys Arg Val Ser Asp Met Arg 
                645                 650                 655     


Ile Glu Pro Gly Met Asn Gly Arg Gln Met Asn Glu Phe Arg Lys Ala 
            660                 665                 670         


Ile Arg Leu Arg Leu Thr Thr Lys His Ala Asp Ala Glu Ile Asp Gly 
        675                 680                 685             


Arg Ser Leu Glu Ser Val Ala Trp Met Ala Asn Glu Leu Arg His Arg 
    690                 695                 700                 


Ile Glu Gly Phe Tyr Arg Ser Ala Glu Asn Asp Val Thr Val Arg Val 
705                 710                 715                 720 


Phe Arg Gly Ala Val Thr Ala Glu Gly Arg Arg Ala Ser Gly Phe Glu 
                725                 730                 735     


Ser Arg Val Asn Leu Ile Gly Gly Lys Gly Lys Thr Arg Leu Asp Arg 
            740                 745                 750         


Arg His His Ala Met Asp Ala Leu Thr Ile Ala Leu Met Glu Pro Gly 
        755                 760                 765             


Ile Ala Gln Thr Ile Ala Leu Arg Met Asn Met Arg Glu Ser Gln Arg 
    770                 775                 780                 


Val Leu Gly Glu Gln Glu Thr Trp Lys Ser Phe Thr Gly Gly Ser Asp 
785                 790                 795                 800 


Thr Ala Arg Lys Arg Trp Glu His Trp Cys Glu Glu Met Leu Arg Ala 
                805                 810                 815     


Ser Glu Leu Phe Asn Val Phe Leu Ala Glu Asp Arg Ile Pro Ile Cys 
            820                 825                 830         


Gln Asn Lys Arg Leu Arg Leu Gly Ser Ser Ala Val His Lys Ala Ile 
        835                 840                 845             


Val Gln Pro Phe Glu Ala Ser Asp Lys Arg Ile Val Ser Asp Ala Met 
    850                 855                 860                 


Pro Val Glu Leu Ile Asp Arg Ala Ser Thr Pro Ala Leu Trp Thr Ala 
865                 870                 875                 880 


Leu Thr Arg Asp Pro Asp Phe Asp Pro Lys Glu Gly Leu Pro Ala Asn 
                885                 890                 895     


Pro Ser Arg Thr Ile Arg Leu His Asp Lys Arg Leu Gly Pro Asn Glu 
            900                 905                 910         


Thr Val Glu Phe Phe Pro Thr Ala Ala Ala Cys Leu Ala Ile Arg Gly 
        915                 920                 925             


Gly Tyr Cys Glu Ile Gly Ala Gly Ile His His Ala Arg Ile Phe Arg 
    930                 935                 940                 


Ile Ser Gly Lys Lys Thr Thr Tyr Ala Met Leu Arg Val Tyr Gln Cys 
945                 950                 955                 960 


Asp Leu Val Arg Phe Gln Lys Glu Asn Leu Leu Thr Val Glu Leu Pro 
                965                 970                 975     


Ala Asn Thr Ile Ser Val Arg Thr Ala Val Pro Lys Leu Arg Glu Ala 
            980                 985                 990         


Leu Ala His Gly Thr Ala Glu Gln  Ile Gly Trp Leu Val  Val Gly Asp 
        995                 1000                 1005             


Glu Leu  Lys Ile Asp Leu Ser  Gly Phe Thr Thr Gly  Gln Ile Glu 
    1010                 1015                 1020             


Thr Phe  Asn Glu Thr Tyr Pro  Gln Ala Thr Arg Trp  Glu Val Thr 
    1025                 1030                 1035             


Gly Phe  Pro Thr Lys Thr Gln  Leu Arg Leu Lys Pro  Leu Leu Ile 
    1040                 1045                 1050             


Ala Ser  Glu Gly Leu Ala Asp  Asp Val Pro Asp Asp  Ile Val Lys 
    1055                 1060                 1065             


Ile Val  Lys Gly Pro Gly Trp  Trp Pro Ala Ile Asp  Lys Leu Leu 
    1070                 1075                 1080             


Lys Ile  Gly Asn Val Val Leu  Tyr Arg Arg Asp Thr  His Gly Lys 
    1085                 1090                 1095             


Pro Arg  Val Val Ser His Arg  Ser Leu Pro Leu Ser  Ser Lys Leu 
    1100                 1105                 1110             


Gln 
    


<210> 58
<211> 1101
<212> PRT
<213> Akkermansia muciniphila

<400> 58
Met Ser Arg Ser Leu Thr Phe Ser Phe Asp Ile Gly Tyr Ala Ser Ile 
1               5                   10                  15      


Gly Trp Ala Val Ile Ala Ser Ala Ser His Asp Asp Ala Asp Pro Ser 
            20                  25                  30          


Val Cys Gly Cys Gly Thr Val Leu Phe Pro Lys Asp Asp Cys Gln Ala 
        35                  40                  45              


Phe Lys Arg Arg Glu Tyr Arg Arg Leu Arg Arg Asn Ile Arg Ser Arg 
    50                  55                  60                  


Arg Val Arg Ile Glu Arg Ile Gly Arg Leu Leu Val Gln Ala Gln Ile 
65                  70                  75                  80  


Ile Thr Pro Glu Met Lys Glu Thr Ser Gly His Pro Ala Pro Phe Tyr 
                85                  90                  95      


Leu Ala Ser Glu Ala Leu Lys Gly His Arg Thr Leu Ala Pro Ile Glu 
            100                 105                 110         


Leu Trp His Val Leu Arg Trp Tyr Ala His Asn Arg Gly Tyr Asp Asn 
        115                 120                 125             


Asn Ala Ser Trp Ser Asn Ser Leu Ser Glu Asp Gly Gly Asn Gly Glu 
    130                 135                 140                 


Asp Thr Glu Arg Val Lys His Ala Gln Asp Leu Met Asp Lys His Gly 
145                 150                 155                 160 


Thr Ala Thr Met Ala Glu Thr Ile Cys Arg Glu Leu Lys Leu Glu Glu 
                165                 170                 175     


Gly Lys Ala Asp Ala Pro Met Glu Val Ser Thr Pro Ala Tyr Lys Asn 
            180                 185                 190         


Leu Asn Thr Ala Phe Pro Arg Leu Ile Val Glu Lys Glu Val Arg Arg 
        195                 200                 205             


Ile Leu Glu Leu Ser Ala Pro Leu Ile Pro Gly Leu Thr Ala Glu Ile 
    210                 215                 220                 


Ile Glu Leu Ile Ala Gln His His Pro Leu Thr Thr Glu Gln Arg Gly 
225                 230                 235                 240 


Val Leu Leu Gln His Gly Ile Lys Leu Ala Arg Arg Tyr Arg Gly Ser 
                245                 250                 255     


Leu Leu Phe Gly Gln Leu Ile Pro Arg Phe Asp Asn Arg Ile Ile Ser 
            260                 265                 270         


Arg Cys Pro Val Thr Trp Ala Gln Val Tyr Glu Ala Glu Leu Lys Lys 
        275                 280                 285             


Gly Asn Ser Glu Gln Ser Ala Arg Glu Arg Ala Glu Lys Leu Ser Lys 
    290                 295                 300                 


Val Pro Thr Ala Asn Cys Pro Glu Phe Tyr Glu Tyr Arg Met Ala Arg 
305                 310                 315                 320 


Ile Leu Cys Asn Ile Arg Ala Asp Gly Glu Pro Leu Ser Ala Glu Ile 
                325                 330                 335     


Arg Arg Glu Leu Met Asn Gln Ala Arg Gln Glu Gly Lys Leu Thr Lys 
            340                 345                 350         


Ala Ser Leu Glu Lys Ala Ile Ser Ser Arg Leu Gly Lys Glu Thr Glu 
        355                 360                 365             


Thr Asn Val Ser Asn Tyr Phe Thr Leu His Pro Asp Ser Glu Glu Ala 
    370                 375                 380                 


Leu Tyr Leu Asn Pro Ala Val Glu Val Leu Gln Arg Ser Gly Ile Gly 
385                 390                 395                 400 


Gln Ile Leu Ser Pro Ser Val Tyr Arg Ile Ala Ala Asn Arg Leu Arg 
                405                 410                 415     


Arg Gly Lys Ser Val Thr Pro Asn Tyr Leu Leu Asn Leu Leu Lys Ser 
            420                 425                 430         


Arg Gly Glu Ser Gly Glu Ala Leu Glu Lys Lys Ile Glu Lys Glu Ser 
        435                 440                 445             


Lys Lys Lys Glu Ala Asp Tyr Ala Asp Thr Pro Leu Lys Pro Lys Tyr 
    450                 455                 460                 


Ala Thr Gly Arg Ala Pro Tyr Ala Arg Thr Val Leu Lys Lys Val Val 
465                 470                 475                 480 


Glu Glu Ile Leu Asp Gly Glu Asp Pro Thr Arg Pro Ala Arg Gly Glu 
                485                 490                 495     


Ala His Pro Asp Gly Glu Leu Lys Ala His Asp Gly Cys Leu Tyr Cys 
            500                 505                 510         


Leu Leu Asp Thr Asp Ser Ser Val Asn Gln His Gln Lys Glu Arg Arg 
        515                 520                 525             


Leu Asp Thr Met Thr Asn Asn His Leu Val Arg His Arg Met Leu Ile 
    530                 535                 540                 


Leu Asp Arg Leu Leu Lys Asp Leu Ile Gln Asp Phe Ala Asp Gly Gln 
545                 550                 555                 560 


Lys Asp Arg Ile Ser Arg Val Cys Val Glu Val Gly Lys Glu Leu Thr 
                565                 570                 575     


Thr Phe Ser Ala Met Asp Ser Lys Lys Ile Gln Arg Glu Leu Thr Leu 
            580                 585                 590         


Arg Gln Lys Ser His Thr Asp Ala Val Asn Arg Leu Lys Arg Lys Leu 
        595                 600                 605             


Pro Gly Lys Ala Leu Ser Ala Asn Leu Ile Arg Lys Cys Arg Ile Ala 
    610                 615                 620                 


Met Asp Met Asn Trp Thr Cys Pro Phe Thr Gly Ala Thr Tyr Gly Asp 
625                 630                 635                 640 


His Glu Leu Glu Asn Leu Glu Leu Glu His Ile Val Pro His Ser Phe 
                645                 650                 655     


Arg Gln Ser Asn Ala Leu Ser Ser Leu Val Leu Thr Trp Pro Gly Val 
            660                 665                 670         


Asn Arg Met Lys Gly Gln Arg Thr Gly Tyr Asp Phe Val Glu Gln Glu 
        675                 680                 685             


Gln Glu Asn Pro Val Pro Asp Lys Pro Asn Leu His Ile Cys Ser Leu 
    690                 695                 700                 


Asn Asn Tyr Arg Glu Leu Val Glu Lys Leu Asp Asp Lys Lys Gly His 
705                 710                 715                 720 


Glu Asp Asp Arg Arg Arg Lys Lys Lys Arg Lys Ala Leu Leu Met Val 
                725                 730                 735     


Arg Gly Leu Ser His Lys His Gln Ser Gln Asn His Glu Ala Met Lys 
            740                 745                 750         


Glu Ile Gly Met Thr Glu Gly Met Met Thr Gln Ser Ser His Leu Met 
        755                 760                 765             


Lys Leu Ala Cys Lys Ser Ile Lys Thr Ser Leu Pro Asp Ala His Ile 
    770                 775                 780                 


Asp Met Ile Pro Gly Ala Val Thr Ala Glu Val Arg Lys Ala Trp Asp 
785                 790                 795                 800 


Val Phe Gly Val Phe Lys Glu Leu Cys Pro Glu Ala Ala Asp Pro Asp 
                805                 810                 815     


Ser Gly Lys Ile Leu Lys Glu Asn Leu Arg Ser Leu Thr His Leu His 
            820                 825                 830         


His Ala Leu Asp Ala Cys Val Leu Gly Leu Ile Pro Tyr Ile Ile Pro 
        835                 840                 845             


Ala His His Asn Gly Leu Leu Arg Arg Val Leu Ala Met Arg Arg Ile 
    850                 855                 860                 


Pro Glu Lys Leu Ile Pro Gln Val Arg Pro Val Ala Asn Gln Arg His 
865                 870                 875                 880 


Tyr Val Leu Asn Asp Asp Gly Arg Met Met Leu Arg Asp Leu Ser Ala 
                885                 890                 895     


Ser Leu Lys Glu Asn Ile Arg Glu Gln Leu Met Glu Gln Arg Val Ile 
            900                 905                 910         


Gln His Val Pro Ala Asp Met Gly Gly Ala Leu Leu Lys Glu Thr Met 
        915                 920                 925             


Gln Arg Val Leu Ser Val Asp Gly Ser Gly Glu Asp Ala Met Val Ser 
    930                 935                 940                 


Leu Ser Lys Lys Lys Asp Gly Lys Lys Glu Lys Asn Gln Val Lys Ala 
945                 950                 955                 960 


Ser Lys Leu Val Gly Val Phe Pro Glu Gly Pro Ser Lys Leu Lys Ala 
                965                 970                 975     


Leu Lys Ala Ala Ile Glu Ile Asp Gly Asn Tyr Gly Val Ala Leu Asp 
            980                 985                 990         


Pro Lys Pro Val Val Ile Arg His  Ile Lys Val Phe Lys  Arg Ile Met 
        995                 1000                 1005             


Ala Leu  Lys Glu Gln Asn Gly  Gly Lys Pro Val Arg  Ile Leu Lys 
    1010                 1015                 1020             


Lys Gly  Met Leu Ile His Leu  Thr Ser Ser Lys Asp  Pro Lys His 
    1025                 1030                 1035             


Ala Gly  Val Trp Arg Ile Glu  Ser Ile Gln Asp Ser  Lys Gly Gly 
    1040                 1045                 1050             


Val Lys  Leu Asp Leu Gln Arg  Ala His Cys Ala Val  Pro Lys Asn 
    1055                 1060                 1065             


Lys Thr  His Glu Cys Asn Trp  Arg Glu Val Asp Leu  Ile Ser Leu 
    1070                 1075                 1080             


Leu Lys  Lys Tyr Gln Met Lys  Arg Tyr Pro Thr Ser  Tyr Thr Gly 
    1085                 1090                 1095             


Thr Pro  Arg 
    1100     


<210> 59
<211> 1113
<212> PRT
<213> Alcanivorax pacificus


<220>
<223> Alcanivorax pacificus W11-5

<400> 59
Met Arg Tyr Arg Val Gly Leu Asp Leu Gly Thr Ala Ser Val Gly Ala 
1               5                   10                  15      


Ala Val Phe Ser Met Asp Glu Gln Gly Asn Pro Met Glu Leu Ile Trp 
            20                  25                  30          


His Tyr Glu Arg Leu Phe Ser Glu Pro Leu Val Pro Asp Met Gly Gln 
        35                  40                  45              


Leu Lys Pro Lys Lys Ala Ala Arg Arg Leu Ala Arg Gln Gln Arg Arg 
    50                  55                  60                  


Gln Ile Asp Arg Arg Ala Ser Arg Leu Arg Arg Ile Ala Ile Val Ser 
65                  70                  75                  80  


Arg Arg Leu Gly Ile Ala Pro Gly Arg Asn Asp Ser Gly Val His Gly 
                85                  90                  95      


Asn Asp Val Pro Thr Leu Arg Ala Met Ala Val Asn Glu Arg Ile Glu 
            100                 105                 110         


Leu Gly Gln Leu Arg Ala Val Leu Leu Arg Met Gly Lys Lys Arg Gly 
        115                 120                 125             


Tyr Gly Gly Thr Phe Lys Ala Val Arg Lys Val Gly Glu Ala Gly Glu 
    130                 135                 140                 


Val Ala Ser Gly Ala Ser Arg Leu Glu Glu Glu Met Val Ala Leu Ala 
145                 150                 155                 160 


Ser Val Gln Asn Lys Asp Ser Val Thr Val Gly Glu Tyr Leu Ala Ala 
                165                 170                 175     


Arg Val Glu His Gly Leu Pro Ser Lys Leu Lys Val Ala Ala Asn Asn 
            180                 185                 190         


Glu Tyr Tyr Ala Pro Glu Tyr Ala Leu Phe Arg Gln Tyr Leu Gly Leu 
        195                 200                 205             


Pro Ala Ile Lys Gly Arg Pro Asp Cys Leu Pro Asn Met Tyr Ala Leu 
    210                 215                 220                 


Arg His Gln Ile Glu His Glu Phe Glu Arg Ile Trp Ala Thr Gln Ser 
225                 230                 235                 240 


Gln Phe His Asp Val Met Lys Asp His Gly Val Lys Glu Glu Ile Arg 
                245                 250                 255     


Asn Ala Ile Phe Phe Gln Arg Pro Leu Lys Ser Pro Ala Asp Lys Val 
            260                 265                 270         


Gly Arg Cys Ser Leu Gln Thr Asn Leu Pro Arg Ala Pro Arg Ala Gln 
        275                 280                 285             


Ile Ala Ala Gln Asn Phe Arg Ile Glu Lys Gln Met Ala Asp Leu Arg 
    290                 295                 300                 


Trp Gly Met Gly Arg Arg Ala Glu Met Leu Asn Asp His Gln Lys Ala 
305                 310                 315                 320 


Val Ile Arg Glu Leu Leu Asn Gln Gln Lys Glu Leu Ser Phe Arg Lys 
                325                 330                 335     


Ile Tyr Lys Glu Leu Glu Arg Ala Gly Cys Pro Gly Pro Glu Gly Lys 
            340                 345                 350         


Gly Leu Asn Met Asp Arg Ala Ala Leu Gly Gly Arg Asp Asp Leu Ser 
        355                 360                 365             


Gly Asn Thr Thr Leu Ala Ala Trp Arg Lys Leu Gly Leu Glu Asp Arg 
    370                 375                 380                 


Trp Gln Glu Leu Asp Glu Val Thr Gln Ile Gln Val Ile Asn Phe Leu 
385                 390                 395                 400 


Ala Asp Leu Gly Ser Pro Glu Gln Leu Asp Thr Asp Asp Trp Ser Cys 
                405                 410                 415     


Arg Phe Met Gly Lys Asn Gly Arg Pro Arg Asn Phe Ser Asp Glu Phe 
            420                 425                 430         


Val Ala Phe Met Asn Glu Leu Arg Met Thr Asp Gly Phe Asp Arg Leu 
        435                 440                 445             


Ser Lys Met Gly Phe Glu Gly Gly Arg Ser Ser Tyr Ser Ile Lys Ala 
    450                 455                 460                 


Leu Lys Ala Leu Thr Glu Trp Met Ile Ala Pro His Trp Arg Glu Thr 
465                 470                 475                 480 


Pro Glu Thr His Arg Val Asp Glu Glu Ala Ala Ile Arg Glu Cys Tyr 
                485                 490                 495     


Pro Glu Ser Leu Ala Thr Pro Ala Gln Gly Gly Arg Gln Ser Lys Leu 
            500                 505                 510         


Glu Pro Pro Pro Leu Thr Gly Asn Glu Val Val Asp Val Ala Leu Arg 
        515                 520                 525             


Gln Val Arg His Thr Ile Asn Met Met Ile Asp Asp Leu Gly Ser Val 
    530                 535                 540                 


Pro Ala Gln Ile Val Val Glu Met Ala Arg Glu Met Lys Gly Gly Val 
545                 550                 555                 560 


Thr Arg Arg Asn Asp Ile Glu Lys Gln Asn Lys Arg Phe Ala Ser Glu 
                565                 570                 575     


Arg Lys Lys Ala Ala Gln Ser Ile Glu Glu Asn Gly Lys Thr Pro Thr 
            580                 585                 590         


Pro Ala Arg Ile Leu Arg Tyr Gln Leu Trp Ile Glu Gln Gly His Gln 
        595                 600                 605             


Cys Pro Tyr Cys Glu Ser Asn Ile Ser Leu Glu Gln Ala Leu Ser Gly 
    610                 615                 620                 


Ala Tyr Thr Asn Phe Glu His Ile Leu Pro Arg Thr Leu Thr Gln Ile 
625                 630                 635                 640 


Gly Arg Lys Arg Ser Glu Leu Val Leu Ala His Arg Glu Cys Asn Asp 
                645                 650                 655     


Glu Lys Gly Asn Arg Thr Pro Tyr Gln Ala Phe Gly His Asp Asp Arg 
            660                 665                 670         


Arg Trp Arg Ile Val Glu Gln Arg Ala Asn Ala Leu Pro Lys Lys Ser 
        675                 680                 685             


Ser Arg Lys Thr Arg Leu Leu Leu Leu Lys Asp Phe Glu Gly Glu Ala 
    690                 695                 700                 


Leu Thr Asp Glu Ser Ile Asp Glu Phe Ala Asp Arg Gln Leu His Glu 
705                 710                 715                 720 


Ser Ser Trp Leu Ala Lys Val Thr Thr Gln Trp Leu Ser Ser Leu Gly 
                725                 730                 735     


Ser Asp Val Tyr Val Ser Arg Gly Ser Leu Thr Ala Glu Leu Arg Arg 
            740                 745                 750         


Arg Trp Gly Leu Asp Thr Val Ile Pro Gln Val Arg Phe Glu Ser Gly 
        755                 760                 765             


Met Pro Val Val Asp Glu Glu Gly Ala Glu Ile Thr Pro Glu Glu Phe 
    770                 775                 780                 


Glu Lys Phe Arg Leu Gln Trp Glu Gly His Arg Val Thr Arg Glu Met 
785                 790                 795                 800 


Arg Thr Asp Arg Arg Pro Asp Lys Arg Ile Asp His Arg His His Leu 
                805                 810                 815     


Val Asp Ala Ile Val Thr Ala Leu Thr Ser Arg Ser Leu Tyr Gln Gln 
            820                 825                 830         


Tyr Ala Lys Ala Trp Lys Val Ala Asp Glu Lys Gln Arg His Gly Arg 
        835                 840                 845             


Val Asp Val Lys Val Glu Leu Pro Met Pro Ile Leu Thr Ile Arg Asp 
    850                 855                 860                 


Ile Ala Leu Glu Ala Val Arg Ser Val Arg Ile Ser His Lys Pro Asp 
865                 870                 875                 880 


Arg Tyr Pro Asp Gly Arg Phe Phe Glu Ala Thr Ala Tyr Gly Ile Ala 
                885                 890                 895     


Gln Arg Leu Asp Glu Arg Ser Gly Glu Lys Val Asp Trp Leu Val Ser 
            900                 905                 910         


Arg Lys Ser Leu Thr Asp Leu Ala Pro Glu Lys Lys Ser Ile Asp Val 
        915                 920                 925             


Asp Lys Val Arg Ala Asn Ile Ser Arg Ile Val Gly Glu Ala Ile Arg 
    930                 935                 940                 


Leu His Ile Ser Asn Ile Phe Glu Lys Arg Val Ser Lys Gly Met Thr 
945                 950                 955                 960 


Pro Gln Gln Ala Leu Arg Glu Pro Ile Glu Phe Gln Gly Asn Ile Leu 
                965                 970                 975     


Arg Lys Val Arg Cys Phe Tyr Ser Lys Ala Asp Asp Cys Val Arg Ile 
            980                 985                 990         


Glu His Ser Ser Arg Arg Gly His  His Tyr Lys Met Leu  Leu Asn Asp 
        995                 1000                 1005             


Gly Phe  Ala Tyr Met Glu Val  Pro Cys Lys Glu Gly  Ile Leu Tyr 
    1010                 1015                 1020             


Gly Val  Pro Asn Leu Val Arg  Pro Ser Glu Ala Val  Gly Ile Lys 
    1025                 1030                 1035             


Arg Ala  Pro Glu Ser Gly Asp  Phe Ile Arg Phe Tyr  Lys Gly Asp 
    1040                 1045                 1050             


Thr Val  Lys Asn Ile Lys Thr  Gly Arg Val Tyr Thr  Ile Lys Gln 
    1055                 1060                 1065             


Ile Leu  Gly Asp Gly Gly Gly  Lys Leu Ile Leu Thr  Pro Val Thr 
    1070                 1075                 1080             


Glu Thr  Lys Pro Ala Asp Leu  Leu Ser Ala Lys Trp  Gly Arg Leu 
    1085                 1090                 1095             


Lys Val  Gly Gly Arg Asn Ile  His Leu Leu Arg Leu  Cys Ala Glu 
    1100                 1105                 1110             


<210> 60
<211> 1029
<212> PRT
<213> Alicycliphilus denitrificans


<220>
<223> Alicycliphilus denitrificans BC

<400> 60
Met Arg Ser Leu Arg Tyr Arg Leu Ala Leu Asp Leu Gly Ser Thr Ser 
1               5                   10                  15      


Leu Gly Trp Ala Leu Phe Arg Leu Asp Ala Cys Asn Arg Pro Thr Ala 
            20                  25                  30          


Val Ile Lys Ala Gly Val Arg Ile Phe Ser Asp Gly Arg Asn Pro Lys 
        35                  40                  45              


Asp Gly Ser Ser Leu Ala Val Thr Arg Arg Ala Ala Arg Ala Met Arg 
    50                  55                  60                  


Arg Arg Arg Asp Arg Leu Leu Lys Arg Lys Thr Arg Met Gln Ala Lys 
65                  70                  75                  80  


Leu Val Glu His Gly Phe Phe Pro Ala Asp Ala Gly Lys Arg Lys Ala 
                85                  90                  95      


Leu Glu Gln Leu Asn Pro Tyr Ala Leu Arg Ala Lys Gly Leu Gln Glu 
            100                 105                 110         


Ala Leu Leu Pro Gly Glu Phe Ala Arg Ala Leu Phe His Ile Asn Gln 
        115                 120                 125             


Arg Arg Gly Phe Lys Ser Asn Arg Lys Thr Asp Lys Lys Asp Asn Asp 
    130                 135                 140                 


Ser Gly Val Leu Lys Lys Ala Ile Gly Gln Leu Arg Gln Gln Met Ala 
145                 150                 155                 160 


Glu Gln Gly Ser Arg Thr Val Gly Glu Tyr Leu Trp Thr Arg Leu Gln 
                165                 170                 175     


Gln Gly Gln Gly Val Arg Ala Arg Tyr Arg Glu Lys Pro Tyr Thr Thr 
            180                 185                 190         


Glu Glu Gly Lys Lys Arg Ile Asp Lys Ser Tyr Asp Leu Tyr Ile Asp 
        195                 200                 205             


Arg Ala Met Ile Glu Gln Glu Phe Asp Ala Leu Trp Ala Ala Gln Ala 
    210                 215                 220                 


Ala Phe Asn Pro Thr Leu Phe His Glu Ala Ala Arg Ala Asp Leu Lys 
225                 230                 235                 240 


Asp Thr Leu Leu His Gln Arg Pro Leu Arg Pro Val Lys Pro Gly Arg 
                245                 250                 255     


Cys Thr Leu Leu Pro Glu Glu Glu Arg Ala Pro Leu Ala Leu Pro Ser 
            260                 265                 270         


Thr Gln Arg Phe Arg Ile His Gln Glu Val Asn His Leu Arg Leu Leu 
        275                 280                 285             


Asp Glu Asn Leu Arg Glu Val Ala Leu Thr Leu Ala Gln Arg Asp Ala 
    290                 295                 300                 


Val Val Thr Ala Leu Glu Thr Lys Ala Lys Leu Ser Phe Glu Gln Ile 
305                 310                 315                 320 


Arg Lys Leu Leu Lys Leu Ser Gly Ser Val Gln Phe Asn Leu Glu Asp 
                325                 330                 335     


Ala Lys Arg Thr Glu Leu Lys Gly Asn Ala Thr Ser Ala Ala Leu Ala 
            340                 345                 350         


Arg Lys Glu Leu Phe Gly Ala Ala Trp Ser Gly Phe Asp Glu Ala Leu 
        355                 360                 365             


Gln Asp Glu Ile Val Trp Gln Leu Val Thr Glu Glu Gly Glu Gly Ala 
    370                 375                 380                 


Leu Ile Ala Trp Leu Gln Thr His Thr Gly Val Asp Glu Ala Arg Ala 
385                 390                 395                 400 


Gln Ala Ile Val Asp Val Ser Leu Pro Glu Gly Tyr Gly Asn Leu Ser 
                405                 410                 415     


Arg Lys Ala Leu Ala Arg Ile Val Pro Ala Leu Arg Ala Ala Val Ile 
            420                 425                 430         


Thr Tyr Asp Lys Ala Val Gln Ala Ala Gly Phe Asp His His Ser Gln 
        435                 440                 445             


Leu Gly Phe Glu Tyr Asp Ala Ser Glu Val Glu Asp Leu Val His Pro 
    450                 455                 460                 


Glu Thr Gly Glu Ile Arg Ser Val Phe Lys Gln Leu Pro Tyr Tyr Gly 
465                 470                 475                 480 


Lys Ala Leu Gln Arg His Val Ala Phe Gly Ser Gly Lys Pro Glu Asp 
                485                 490                 495     


Pro Asp Glu Lys Arg Tyr Gly Lys Ile Ala Asn Pro Thr Val His Ile 
            500                 505                 510         


Gly Leu Asn Gln Val Arg Met Val Val Asn Ala Leu Ile Arg Arg Tyr 
        515                 520                 525             


Gly Arg Pro Thr Glu Val Val Ile Glu Leu Ala Arg Asp Leu Lys Gln 
    530                 535                 540                 


Ser Arg Glu Gln Lys Val Glu Ala Gln Arg Arg Gln Ala Asp Asn Gln 
545                 550                 555                 560 


Arg Arg Asn Ala Arg Ile Arg Arg Ser Ile Ala Glu Val Leu Gly Ile 
                565                 570                 575     


Gly Glu Glu Arg Val Arg Gly Ser Asp Ile Gln Lys Trp Ile Cys Trp 
            580                 585                 590         


Glu Glu Leu Ser Phe Asp Ala Ala Asp Arg Arg Cys Pro Tyr Ser Gly 
        595                 600                 605             


Val Gln Ile Ser Ala Ala Met Leu Leu Ser Asp Glu Val Glu Val Glu 
    610                 615                 620                 


His Ile Leu Pro Phe Ser Lys Thr Leu Asp Asp Ser Leu Asn Asn Arg 
625                 630                 635                 640 


Thr Val Ala Met Arg Gln Ala Asn Arg Ile Lys Arg Asn Arg Thr Pro 
                645                 650                 655     


Trp Asp Ala Arg Ala Glu Phe Glu Ala Gln Gly Trp Ser Tyr Glu Asp 
            660                 665                 670         


Ile Leu Gln Arg Ala Glu Arg Met Pro Leu Arg Lys Arg Tyr Arg Phe 
        675                 680                 685             


Ala Pro Asp Gly Tyr Glu Arg Trp Leu Gly Asp Asp Lys Asp Phe Leu 
    690                 695                 700                 


Ala Arg Ala Leu Asn Asp Thr Arg Tyr Leu Ser Arg Val Ala Ala Glu 
705                 710                 715                 720 


Tyr Leu Arg Leu Val Cys Pro Gly Thr Arg Val Ile Pro Gly Gln Leu 
                725                 730                 735     


Thr Ala Leu Leu Arg Gly Lys Phe Gly Leu Asn Asp Val Leu Gly Leu 
            740                 745                 750         


Asp Gly Glu Lys Asn Arg Asn Asp His Arg His His Ala Val Asp Ala 
        755                 760                 765             


Cys Val Ile Gly Val Thr Asp Gln Gly Leu Met Gln Arg Phe Ala Thr 
    770                 775                 780                 


Ala Ser Ala Gln Ala Arg Gly Asp Gly Leu Thr Arg Leu Val Asp Gly 
785                 790                 795                 800 


Met Pro Met Pro Trp Pro Thr Tyr Arg Asp His Val Glu Arg Ala Val 
                805                 810                 815     


Arg His Ile Trp Val Ser His Arg Pro Asp His Gly Phe Glu Gly Ala 
            820                 825                 830         


Met Met Glu Glu Thr Ser Tyr Gly Ile Arg Lys Asp Gly Ser Ile Lys 
        835                 840                 845             


Gln Arg Arg Lys Ala Asp Gly Ser Ala Gly Arg Glu Ile Ser Asn Leu 
    850                 855                 860                 


Ile Arg Ile His Glu Ala Thr Gln Pro Leu Arg His Gly Val Ser Ala 
865                 870                 875                 880 


Asp Gly Gln Pro Leu Ala Tyr Lys Gly Tyr Val Gly Gly Ser Asn Tyr 
                885                 890                 895     


Cys Ile Glu Ile Thr Val Asn Asp Lys Gly Lys Trp Glu Gly Glu Val 
            900                 905                 910         


Ile Ser Thr Phe Arg Ala Tyr Gly Val Val Arg Ala Gly Gly Met Gly 
        915                 920                 925             


Arg Leu Arg Asn Pro His Glu Gly Gln Asn Gly Arg Lys Leu Ile Met 
    930                 935                 940                 


Arg Leu Val Ile Gly Asp Ser Val Arg Leu Glu Val Asp Gly Ala Glu 
945                 950                 955                 960 


Arg Thr Met Arg Ile Val Lys Ile Ser Gly Ser Asn Gly Gln Ile Phe 
                965                 970                 975     


Met Ala Pro Ile His Glu Ala Asn Val Asp Ala Arg Asn Thr Asp Lys 
            980                 985                 990         


Gln Asp Ala Phe Thr Tyr Thr Ser  Lys Tyr Ala Gly Ser  Leu Gln Lys 
        995                 1000                 1005             


Ala Lys  Thr Arg Arg Val Thr  Ile Ser Pro Ile Gly  Glu Val Arg 
    1010                 1015                 1020             


Asp Pro  Gly Phe Lys Gly 
    1025                 


<210> 61
<211> 1029
<212> PRT
<213> Alicycliphilus sp.

<400> 61
Met Arg Ser Leu Arg Tyr Arg Leu Ala Leu Asp Leu Gly Ser Thr Ser 
1               5                   10                  15      


Leu Gly Trp Ala Leu Phe Arg Leu Asp Ala Cys Asn Arg Pro Thr Ala 
            20                  25                  30          


Val Ile Lys Ala Gly Val Arg Ile Phe Ser Asp Gly Arg Asn Pro Lys 
        35                  40                  45              


Asp Gly Ser Ser Leu Ala Val Thr Arg Arg Ala Ala Arg Ala Met Arg 
    50                  55                  60                  


Arg Arg Arg Asp Arg Leu Leu Lys Arg Lys Thr Arg Met Gln Ala Lys 
65                  70                  75                  80  


Leu Val Glu His Gly Phe Phe Pro Ala Asp Ala Gly Lys Arg Lys Ala 
                85                  90                  95      


Leu Glu Gln Leu Asn Pro Tyr Ala Leu Arg Ala Lys Gly Leu Gln Glu 
            100                 105                 110         


Ala Leu Leu Pro Gly Glu Phe Ala Arg Ala Leu Phe His Ile Asn Gln 
        115                 120                 125             


Arg Arg Gly Phe Lys Ser Asn Arg Lys Thr Asp Lys Lys Asp Asn Asp 
    130                 135                 140                 


Ser Gly Val Leu Lys Lys Ala Ile Gly Gln Leu Arg Gln Gln Met Ala 
145                 150                 155                 160 


Glu Gln Gly Ser Arg Thr Val Gly Glu Tyr Leu Trp Thr Arg Leu Gln 
                165                 170                 175     


Gln Gly Gln Gly Val Arg Ala Arg Tyr Arg Glu Lys Pro Tyr Thr Thr 
            180                 185                 190         


Glu Glu Gly Lys Lys Arg Ile Asp Lys Ser Tyr Asp Leu Tyr Ile Asp 
        195                 200                 205             


Arg Ala Met Ile Glu Gln Glu Phe Asp Ala Leu Trp Ala Ala Gln Ala 
    210                 215                 220                 


Ala Phe Asn Pro Thr Leu Phe His Glu Ala Ala Arg Ala Asp Leu Lys 
225                 230                 235                 240 


Asp Thr Leu Leu His Gln Arg Pro Leu Arg Pro Val Lys Pro Gly Arg 
                245                 250                 255     


Cys Thr Leu Leu Pro Glu Glu Glu Arg Ala Pro Leu Ala Leu Pro Ser 
            260                 265                 270         


Thr Gln Arg Phe Arg Ile His Gln Glu Val Asn His Leu Arg Leu Leu 
        275                 280                 285             


Asp Glu Asn Leu Arg Glu Val Ala Leu Thr Leu Ala Gln Arg Asp Ala 
    290                 295                 300                 


Val Val Thr Ala Leu Glu Thr Lys Ala Lys Leu Ser Phe Glu Gln Ile 
305                 310                 315                 320 


Arg Lys Leu Leu Lys Leu Ser Gly Ser Val Gln Phe Asn Leu Glu Asp 
                325                 330                 335     


Ala Lys Arg Thr Glu Leu Lys Gly Asn Ala Thr Ser Ala Ala Leu Ala 
            340                 345                 350         


Arg Lys Glu Leu Phe Gly Ala Ala Trp Ser Gly Phe Asp Glu Ala Leu 
        355                 360                 365             


Gln Asp Glu Ile Val Trp Gln Leu Val Thr Glu Glu Gly Glu Gly Ala 
    370                 375                 380                 


Leu Ile Ala Trp Leu Gln Thr His Thr Gly Val Asp Glu Ala Arg Ala 
385                 390                 395                 400 


Gln Ala Ile Val Asp Val Ser Leu Pro Glu Gly Tyr Gly Asn Leu Ser 
                405                 410                 415     


Arg Lys Ala Leu Ala Arg Ile Val Pro Ala Leu Arg Ala Ala Val Ile 
            420                 425                 430         


Thr Tyr Asp Lys Ala Val Gln Ala Ala Gly Phe Asp His His Ser Gln 
        435                 440                 445             


Leu Gly Phe Glu Tyr Asp Ala Ser Glu Val Glu Asp Leu Val His Pro 
    450                 455                 460                 


Glu Thr Gly Glu Ile Arg Ser Val Phe Lys Gln Leu Pro Tyr Tyr Gly 
465                 470                 475                 480 


Lys Ala Leu Gln Arg His Val Ala Phe Gly Ser Gly Lys Pro Glu Asp 
                485                 490                 495     


Pro Asp Glu Lys Arg Tyr Gly Lys Ile Ala Asn Pro Thr Val His Ile 
            500                 505                 510         


Gly Leu Asn Gln Val Arg Met Val Val Asn Ala Leu Ile Arg Arg Tyr 
        515                 520                 525             


Gly Arg Pro Thr Glu Val Val Ile Glu Leu Ala Arg Asp Leu Lys Gln 
    530                 535                 540                 


Ser Arg Glu Gln Lys Val Glu Ala Gln Arg Arg Gln Ala Asp Asn Gln 
545                 550                 555                 560 


Arg Arg Asn Ala Arg Ile Arg Arg Ser Ile Ala Glu Val Leu Gly Ile 
                565                 570                 575     


Gly Glu Glu Arg Val Arg Gly Ser Asp Ile Gln Lys Trp Ile Cys Trp 
            580                 585                 590         


Glu Glu Leu Ser Phe Asp Ala Ala Asp Arg Arg Cys Pro Tyr Ser Gly 
        595                 600                 605             


Val Gln Ile Ser Ala Ala Met Leu Leu Ser Asp Glu Val Glu Val Glu 
    610                 615                 620                 


His Ile Leu Pro Phe Ser Lys Thr Leu Asp Asp Ser Leu Asn Asn Arg 
625                 630                 635                 640 


Thr Val Ala Met Arg Gln Ala Asn Arg Ile Lys Arg Asn Arg Thr Pro 
                645                 650                 655     


Trp Asp Ala Arg Ala Glu Phe Glu Ala Gln Gly Trp Ser Tyr Glu Asp 
            660                 665                 670         


Ile Leu Gln Arg Ala Glu Arg Met Pro Leu Arg Lys Arg Tyr Arg Phe 
        675                 680                 685             


Ala Pro Asp Gly Tyr Glu Arg Trp Leu Gly Asp Asp Lys Asp Phe Leu 
    690                 695                 700                 


Ala Arg Ala Leu Asn Asp Thr Arg Tyr Leu Ser Arg Val Ala Ala Glu 
705                 710                 715                 720 


Tyr Leu Arg Leu Val Cys Pro Gly Thr Arg Val Ile Pro Gly Gln Leu 
                725                 730                 735     


Thr Ala Leu Leu Arg Gly Lys Phe Gly Leu Asn Asp Val Leu Gly Leu 
            740                 745                 750         


Asp Gly Glu Lys Asn Arg Asn Asp His Arg His His Ala Val Asp Ala 
        755                 760                 765             


Cys Val Ile Gly Val Thr Asp Gln Gly Leu Met Gln Arg Phe Ala Thr 
    770                 775                 780                 


Ala Ser Ala Gln Ala Arg Gly Asp Gly Leu Thr Arg Leu Val Asp Gly 
785                 790                 795                 800 


Met Pro Met Pro Trp Pro Thr Tyr Arg Asp His Val Glu Arg Ala Val 
                805                 810                 815     


Arg His Ile Trp Val Ser His Arg Pro Asp His Gly Phe Glu Gly Ala 
            820                 825                 830         


Met Met Glu Glu Thr Ser Tyr Gly Ile Arg Lys Asp Gly Ser Ile Lys 
        835                 840                 845             


Gln Arg Arg Lys Ala Asp Gly Ser Ala Gly Arg Glu Ile Ser Asn Leu 
    850                 855                 860                 


Ile Arg Ile His Glu Ala Thr Gln Pro Leu Arg His Gly Val Ser Ala 
865                 870                 875                 880 


Asp Gly Gln Pro Leu Ala Tyr Lys Gly Tyr Val Gly Gly Ser Asn Tyr 
                885                 890                 895     


Cys Ile Glu Ile Thr Val Asn Asp Lys Gly Lys Trp Glu Gly Glu Val 
            900                 905                 910         


Ile Ser Thr Phe Arg Ala Tyr Gly Val Val Arg Ala Gly Gly Met Gly 
        915                 920                 925             


Arg Leu Arg Asn Pro His Glu Gly Gln Asn Gly Arg Lys Leu Ile Met 
    930                 935                 940                 


Arg Leu Val Ile Gly Asp Ser Val Arg Leu Glu Val Asp Gly Ala Glu 
945                 950                 955                 960 


Arg Thr Met Arg Ile Val Lys Ile Ser Gly Ser Asn Gly Gln Ile Phe 
                965                 970                 975     


Met Ala Pro Ile His Glu Ala Asn Val Asp Ala Arg Asn Thr Asp Lys 
            980                 985                 990         


Gln Asp Ala Phe Thr Tyr Thr Ser  Lys Tyr Ala Gly Ser  Leu Gln Lys 
        995                 1000                 1005             


Ala Lys  Thr Arg Arg Val Thr  Ile Ser Pro Ile Gly  Glu Val Arg 
    1010                 1015                 1020             


Asp Pro  Gly Phe Lys Gly 
    1025                 


<210> 62
<211> 1146
<212> PRT
<213> Alicyclobacillus hesperidum


<220>
<223> Alicyclobacillus hesperidum URH17-3-68

<400> 62
Met Ala Tyr Arg Leu Gly Leu Asp Ile Gly Ile Thr Ser Val Gly Trp 
1               5                   10                  15      


Ala Val Val Ala Leu Glu Lys Asp Glu Ser Gly Leu Lys Pro Val Arg 
            20                  25                  30          


Ile Gln Asp Leu Gly Val Arg Ile Phe Asp Lys Ala Glu Asp Ser Lys 
        35                  40                  45              


Thr Gly Ala Ser Leu Ala Leu Pro Arg Arg Glu Ala Arg Ser Ala Arg 
    50                  55                  60                  


Arg Arg Thr Arg Arg Arg Arg His Arg Leu Trp Arg Val Lys Arg Leu 
65                  70                  75                  80  


Leu Glu Gln His Gly Ile Leu Ser Met Glu Gln Ile Glu Ala Leu Tyr 
                85                  90                  95      


Ala Gln Arg Thr Ser Ser Pro Asp Val Tyr Ala Leu Arg Val Ala Gly 
            100                 105                 110         


Leu Asp Arg Cys Leu Ile Ala Glu Glu Ile Ala Arg Val Leu Ile His 
        115                 120                 125             


Ile Ala His Arg Arg Gly Phe Gln Ser Asn Arg Lys Ser Glu Ile Lys 
    130                 135                 140                 


Asp Ser Asp Ala Gly Lys Leu Leu Lys Ala Val Gln Glu Asn Glu Asn 
145                 150                 155                 160 


Leu Met Gln Ser Lys Gly Tyr Arg Thr Val Ala Glu Met Leu Val Ser 
                165                 170                 175     


Glu Ala Thr Lys Thr Asp Ala Glu Gly Lys Leu Val His Gly Lys Lys 
            180                 185                 190         


His Gly Tyr Val Ser Asn Val Arg Asn Lys Ala Gly Glu Tyr Arg His 
        195                 200                 205             


Thr Val Ser Arg Gln Ala Ile Val Asp Glu Val Arg Lys Ile Phe Ala 
    210                 215                 220                 


Ala Gln Arg Ala Leu Gly Asn Asp Val Met Ser Glu Glu Leu Glu Asp 
225                 230                 235                 240 


Ser Tyr Leu Lys Ile Leu Cys Ser Gln Arg Asn Phe Asp Asp Gly Pro 
                245                 250                 255     


Gly Gly Asp Ser Pro Tyr Gly His Gly Ser Val Ser Pro Asp Gly Val 
            260                 265                 270         


Arg Gln Ser Ile Tyr Glu Arg Met Val Gly Ser Cys Thr Phe Glu Thr 
        275                 280                 285             


Gly Glu Lys Arg Ala Pro Arg Ser Ser Tyr Ser Phe Glu Arg Phe Gln 
    290                 295                 300                 


Leu Leu Thr Lys Val Val Asn Leu Arg Ile Tyr Arg Gln Gln Glu Asp 
305                 310                 315                 320 


Gly Gly Arg Tyr Pro Cys Glu Leu Thr Gln Thr Glu Arg Ala Arg Val 
                325                 330                 335     


Ile Asp Cys Ala Tyr Glu Gln Thr Lys Ile Thr Tyr Gly Lys Leu Arg 
            340                 345                 350         


Lys Leu Leu Asp Met Lys Asp Thr Glu Ser Phe Ala Gly Leu Thr Tyr 
        355                 360                 365             


Gly Leu Asn Arg Ser Arg Asn Lys Thr Glu Asp Thr Val Phe Val Glu 
    370                 375                 380                 


Met Lys Phe Tyr His Glu Val Arg Lys Ala Leu Gln Arg Ala Gly Val 
385                 390                 395                 400 


Phe Ile Gln Asp Leu Ser Ile Glu Thr Leu Asp Gln Ile Gly Trp Ile 
                405                 410                 415     


Leu Ser Val Trp Lys Ser Asp Asp Asn Arg Arg Lys Lys Leu Ser Thr 
            420                 425                 430         


Leu Gly Leu Ser Asp Asn Val Ile Glu Glu Leu Leu Pro Leu Asn Gly 
        435                 440                 445             


Ser Lys Phe Gly His Leu Ser Leu Lys Ala Ile Arg Lys Ile Leu Pro 
    450                 455                 460                 


Phe Leu Glu Asp Gly Tyr Ser Tyr Asp Val Ala Cys Glu Leu Ala Gly 
465                 470                 475                 480 


Tyr Gln Phe Gln Gly Lys Thr Glu Tyr Val Lys Gln Arg Leu Leu Pro 
                485                 490                 495     


Pro Leu Gly Glu Gly Glu Val Thr Asn Pro Val Val Arg Arg Ala Leu 
            500                 505                 510         


Ser Gln Ala Ile Lys Val Val Asn Ala Val Ile Arg Lys His Gly Ser 
        515                 520                 525             


Pro Glu Ser Ile His Ile Glu Leu Ala Arg Glu Leu Ser Lys Asn Leu 
    530                 535                 540                 


Asp Glu Arg Arg Lys Ile Glu Lys Ala Gln Lys Glu Asn Gln Lys Asn 
545                 550                 555                 560 


Asn Glu Gln Ile Lys Asp Glu Ile Arg Glu Ile Leu Gly Ser Ala His 
                565                 570                 575     


Val Thr Gly Arg Asp Ile Val Lys Tyr Lys Leu Phe Lys Gln Gln Gln 
            580                 585                 590         


Glu Phe Cys Met Tyr Ser Gly Glu Lys Leu Asp Val Thr Arg Leu Phe 
        595                 600                 605             


Glu Pro Gly Tyr Ala Glu Val Asp His Ile Ile Pro Tyr Gly Ile Ser 
    610                 615                 620                 


Phe Asp Asp Ser Tyr Asp Asn Lys Val Leu Val Lys Thr Glu Gln Asn 
625                 630                 635                 640 


Arg Gln Lys Gly Asn Arg Thr Pro Leu Glu Tyr Leu Arg Asp Lys Pro 
                645                 650                 655     


Glu Gln Lys Ala Lys Phe Ile Ala Leu Val Glu Ser Ile Pro Leu Ser 
            660                 665                 670         


Gln Lys Lys Lys Asn His Leu Leu Met Asp Lys Arg Ala Ile Asp Leu 
        675                 680                 685             


Glu Gln Glu Gly Phe Arg Glu Arg Asn Leu Ser Asp Thr Arg Tyr Ile 
    690                 695                 700                 


Thr Arg Ala Leu Met Asn His Ile Gln Ala Trp Leu Leu Phe Asp Glu 
705                 710                 715                 720 


Thr Ala Ser Thr Arg Ser Lys Arg Val Val Cys Val Asn Gly Ala Val 
                725                 730                 735     


Thr Ala Tyr Met Arg Ala Arg Trp Gly Leu Thr Lys Asp Arg Asp Ala 
            740                 745                 750         


Gly Asp Lys His His Ala Ala Asp Ala Val Val Val Ala Cys Ile Gly 
        755                 760                 765             


Asp Ser Leu Ile Gln Arg Val Thr Lys Tyr Asp Lys Phe Lys Arg Asn 
    770                 775                 780                 


Ala Leu Ala Asp Arg Asn Arg Tyr Val Gln Gln Val Ser Lys Ser Glu 
785                 790                 795                 800 


Gly Ile Thr Gln Tyr Val Asp Lys Glu Thr Gly Glu Val Phe Thr Trp 
                805                 810                 815     


Glu Ser Phe Asp Glu Arg Lys Phe Leu Pro Asn Glu Pro Leu Glu Pro 
            820                 825                 830         


Trp Pro Phe Phe Arg Asp Glu Leu Leu Ala Arg Leu Ser Asp Asp Pro 
        835                 840                 845             


Ser Lys Asn Ile Arg Ala Ile Gly Leu Leu Thr Tyr Ser Glu Thr Glu 
    850                 855                 860                 


Gln Ile Asp Pro Ile Phe Val Ser Arg Met Pro Thr Arg Lys Val Thr 
865                 870                 875                 880 


Gly Ala Ala His Lys Glu Thr Ile Arg Ser Pro Arg Ile Val Lys Val 
                885                 890                 895     


Asp Asp Asn Lys Gly Thr Glu Ile Gln Val Val Val Ser Lys Val Ala 
            900                 905                 910         


Leu Thr Glu Leu Lys Leu Thr Lys Asp Gly Glu Ile Lys Asp Tyr Phe 
        915                 920                 925             


Arg Pro Glu Asp Asp Pro Arg Leu Tyr Asn Thr Leu Arg Glu Arg Leu 
    930                 935                 940                 


Val Gln Phe Gly Gly Asp Ala Lys Ala Ala Phe Lys Glu Pro Val Tyr 
945                 950                 955                 960 


Lys Ile Ser Lys Asp Gly Ser Val Arg Thr Pro Val Arg Lys Val Lys 
                965                 970                 975     


Ile Gln Glu Lys Leu Thr Leu Gly Val Pro Val His Gly Gly Arg Gly 
            980                 985                 990         


Ile Ala Glu Asn Gly Gly Met Val  Arg Ile Asp Val Phe  Ala Lys Gly 
        995                 1000                 1005             


Gly Lys  Tyr Tyr Phe Val Pro  Ile Tyr Val Ala Asp  Val Leu Lys 
    1010                 1015                 1020             


Arg Glu  Leu Pro Asn Arg Leu  Ala Thr Ala His Lys  Pro Tyr Ser 
    1025                 1030                 1035             


Glu Trp  Arg Val Val Asp Asp  Ser Tyr Gln Phe Lys  Phe Ser Leu 
    1040                 1045                 1050             


Tyr Pro  Asn Asp Ala Val Met  Ile Lys Pro Ser Arg  Glu Val Asp 
    1055                 1060                 1065             


Ile Thr  Tyr Lys Asp Arg Lys  Glu Pro Val Gly Cys  Arg Ile Met 
    1070                 1075                 1080             


Tyr Phe  Val Ser Ala Asn Ile  Ala Ser Ala Ser Ile  Ser Leu Arg 
    1085                 1090                 1095             


Thr His  Asp Asn Ser Gly Glu  Leu Glu Gly Leu Gly  Ile Gln Gly 
    1100                 1105                 1110             


Leu Glu  Val Phe Glu Lys Tyr  Val Val Gly Pro Leu  Gly Asp Thr 
    1115                 1120                 1125             


His Pro  Val Tyr Lys Glu Arg  Arg Met Pro Phe Arg  Val Glu Arg 
    1130                 1135                 1140             


Lys Met  Asn 
    1145     


<210> 63
<211> 1052
<212> PRT
<213> Aminomonas paucivorans


<220>
<223> Aminomonas paucivorans DSM 12260

<400> 63
Met Ile Gly Glu His Val Arg Gly Gly Cys Leu Phe Asp Asp His Trp 
1               5                   10                  15      


Thr Pro Asn Trp Gly Ala Phe Arg Leu Pro Asn Thr Val Arg Thr Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Asp Gly Ser Ser Leu Ala Glu Pro Arg 
        35                  40                  45              


Arg Gln Ala Arg Gly Leu Arg Arg Arg Leu Arg Arg Lys Thr Gln Arg 
    50                  55                  60                  


Leu Glu Asp Leu Arg Arg Leu Leu Ala Lys Glu Gly Val Leu Ser Leu 
65                  70                  75                  80  


Ser Asp Leu Glu Thr Leu Phe Arg Glu Thr Pro Ala Lys Asp Pro Tyr 
                85                  90                  95      


Gln Leu Arg Ala Glu Gly Leu Asp Arg Pro Leu Ser Phe Pro Glu Trp 
            100                 105                 110         


Val Arg Val Leu Tyr His Ile Thr Lys His Arg Gly Phe Gln Ser Asn 
        115                 120                 125             


Arg Arg Asn Pro Val Glu Asp Gly Gln Glu Arg Ser Arg Gln Glu Glu 
    130                 135                 140                 


Glu Gly Lys Leu Leu Ser Gly Val Gly Glu Asn Glu Arg Leu Leu Arg 
145                 150                 155                 160 


Glu Gly Gly Tyr Arg Thr Ala Gly Glu Met Leu Ala Arg Asp Pro Lys 
                165                 170                 175     


Phe Gln Asp His Arg Arg Asn Arg Ala Gly Asp Tyr Ser His Thr Leu 
            180                 185                 190         


Ser Arg Ser Leu Leu Leu Glu Glu Ala Arg Arg Leu Phe Gln Ser Gln 
        195                 200                 205             


Arg Thr Leu Gly Asn Pro His Ala Ser Ser Asn Leu Glu Glu Ala Phe 
    210                 215                 220                 


Leu His Leu Val Ala Phe Gln Asn Pro Phe Ala Ser Gly Glu Asp Ile 
225                 230                 235                 240 


Arg Asn Lys Ala Gly His Cys Ser Leu Glu Pro Asp Gln Ile Arg Ala 
                245                 250                 255     


Pro Arg Arg Ser Ala Ser Ala Glu Thr Phe Met Leu Leu Gln Lys Thr 
            260                 265                 270         


Gly Asn Leu Arg Leu Ile His Arg Arg Thr Gly Glu Glu Arg Pro Leu 
        275                 280                 285             


Thr Asp Lys Glu Arg Glu Gln Ile His Leu Leu Ala Trp Lys Gln Glu 
    290                 295                 300                 


Lys Val Thr His Lys Thr Leu Arg Arg His Leu Glu Ile Pro Glu Glu 
305                 310                 315                 320 


Trp Leu Phe Thr Gly Leu Pro Tyr His Arg Ser Gly Asp Lys Ala Glu 
                325                 330                 335     


Glu Lys Leu Phe Val His Leu Ala Gly Ile His Glu Ile Arg Lys Ala 
            340                 345                 350         


Leu Asp Lys Gly Pro Asp Pro Ala Val Trp Asp Thr Leu Arg Ser Arg 
        355                 360                 365             


Arg Asp Leu Leu Asp Ser Ile Ala Asp Thr Leu Thr Phe Tyr Lys Asn 
    370                 375                 380                 


Glu Asp Glu Ile Leu Pro Arg Leu Glu Ser Leu Gly Leu Ser Pro Glu 
385                 390                 395                 400 


Asn Ala Arg Ala Leu Ala Pro Leu Ser Phe Ser Gly Thr Ala His Leu 
                405                 410                 415     


Ser Leu Ser Ala Leu Gly Lys Leu Leu Pro His Leu Glu Glu Gly Lys 
            420                 425                 430         


Ser Tyr Thr Gln Ala Arg Ala Asp Ala Gly Tyr Ala Ala Pro Pro Pro 
        435                 440                 445             


Asp Arg His Pro Lys Leu Pro Pro Leu Glu Glu Ala Asp Trp Arg Asn 
    450                 455                 460                 


Pro Val Val Phe Arg Ala Leu Thr Gln Thr Arg Lys Val Val Asn Ala 
465                 470                 475                 480 


Leu Val Arg Arg Tyr Gly Pro Pro Trp Cys Ile His Leu Glu Thr Ala 
                485                 490                 495     


Arg Glu Leu Ser Gln Pro Ala Lys Val Arg Arg Arg Ile Glu Thr Glu 
            500                 505                 510         


Gln Gln Ala Asn Glu Lys Lys Lys Gln Gln Ala Glu Arg Glu Phe Leu 
        515                 520                 525             


Asp Ile Val Gly Thr Ala Pro Gly Pro Gly Asp Leu Leu Lys Met Arg 
    530                 535                 540                 


Leu Trp Arg Glu Gln Gly Gly Phe Cys Pro Tyr Cys Glu Glu Tyr Leu 
545                 550                 555                 560 


Asn Pro Thr Arg Leu Ala Glu Pro Gly Tyr Ala Glu Met Asp His Ile 
                565                 570                 575     


Leu Pro Tyr Ser Arg Ser Leu Asp Asn Gly Trp His Asn Arg Val Leu 
            580                 585                 590         


Val His Gly Lys Asp Asn Arg Asp Lys Gly Asn Arg Thr Pro Phe Glu 
        595                 600                 605             


Ala Phe Gly Gly Asp Thr Ala Arg Trp Asp Arg Leu Val Ala Trp Val 
    610                 615                 620                 


Gln Ala Ser His Leu Ser Ala Pro Lys Lys Arg Asn Leu Leu Arg Glu 
625                 630                 635                 640 


Asp Phe Gly Glu Glu Ala Glu Arg Glu Leu Lys Asp Arg Asn Leu Thr 
                645                 650                 655     


Asp Thr Arg Phe Ile Thr Lys Thr Ala Ala Thr Leu Leu Arg Asp Arg 
            660                 665                 670         


Leu Thr Phe His Pro Glu Ala Pro Lys Asp Pro Val Met Thr Leu Asn 
        675                 680                 685             


Gly Arg Leu Thr Ala Phe Leu Arg Lys Gln Trp Gly Leu His Lys Asn 
    690                 695                 700                 


Arg Lys Asn Gly Asp Leu His His Ala Leu Asp Ala Ala Val Leu Ala 
705                 710                 715                 720 


Val Ala Ser Arg Ser Phe Val Tyr Arg Leu Ser Ser His Asn Ala Ala 
                725                 730                 735     


Trp Gly Glu Leu Pro Arg Gly Arg Glu Ala Glu Asn Gly Phe Ser Leu 
            740                 745                 750         


Pro Tyr Pro Ala Phe Arg Ser Glu Val Leu Ala Arg Leu Cys Pro Thr 
        755                 760                 765             


Arg Glu Glu Ile Leu Leu Arg Leu Asp Gln Gly Gly Val Gly Tyr Asp 
    770                 775                 780                 


Glu Ala Phe Arg Asn Gly Leu Arg Pro Val Phe Val Ser Arg Ala Pro 
785                 790                 795                 800 


Ser Arg Arg Leu Arg Gly Lys Ala His Met Glu Thr Leu Arg Ser Pro 
                805                 810                 815     


Lys Trp Lys Asp His Pro Glu Gly Pro Arg Thr Ala Ser Arg Ile Pro 
            820                 825                 830         


Leu Lys Asp Leu Asn Leu Glu Lys Leu Glu Arg Met Val Gly Lys Asp 
        835                 840                 845             


Arg Asp Arg Lys Leu Tyr Glu Ala Leu Arg Glu Arg Leu Ala Ala Phe 
    850                 855                 860                 


Gly Gly Asn Gly Lys Lys Ala Phe Val Ala Pro Phe Arg Lys Pro Cys 
865                 870                 875                 880 


Arg Ser Gly Glu Gly Pro Leu Val Arg Ser Leu Arg Ile Phe Asp Ser 
                885                 890                 895     


Gly Tyr Ser Gly Val Glu Leu Arg Asp Gly Gly Glu Val Tyr Ala Val 
            900                 905                 910         


Ala Asp His Glu Ser Met Val Arg Val Asp Val Tyr Ala Lys Lys Asn 
        915                 920                 925             


Arg Phe Tyr Leu Val Pro Val Tyr Val Ala Asp Val Ala Arg Gly Ile 
    930                 935                 940                 


Val Lys Asn Arg Ala Ile Val Ala His Lys Ser Glu Glu Glu Trp Asp 
945                 950                 955                 960 


Leu Val Asp Gly Ser Phe Asp Phe Arg Phe Ser Leu Phe Pro Gly Asp 
                965                 970                 975     


Leu Val Glu Ile Glu Lys Lys Asp Gly Ala Tyr Leu Gly Tyr Tyr Lys 
            980                 985                 990         


Ser Cys His Arg Gly Asp Gly Arg  Leu Leu Leu Asp Arg  His Asp Arg 
        995                 1000                 1005             


Met Pro  Arg Glu Ser Asp Cys  Gly Thr Phe Tyr Val  Ser Thr Arg 
    1010                 1015                 1020             


Lys Asp  Val Leu Ser Met Ser  Lys Tyr Gln Val Asp  Pro Leu Gly 
    1025                 1030                 1035             


Glu Ile  Arg Leu Val Gly Ser  Glu Lys Pro Pro Phe  Val Leu 
    1040                 1045                 1050         


<210> 64
<211> 1361
<212> PRT
<213> Anaerococcus tetradius


<220>
<223> Anaerococcus tetradius ATCC 35098

<400> 64
Met Gly Asn Tyr Tyr Leu Gly Leu Asp Ile Gly Thr Asn Ser Val Gly 
1               5                   10                  15      


Trp Ala Val Thr Asp Glu Asn Tyr Asn Ile Glu Arg Phe Lys Lys Lys 
            20                  25                  30          


Asn Met Trp Gly Ile Arg Leu Phe Asp Glu Ala Lys Thr Ala Glu Ser 
        35                  40                  45              


Arg Arg Ile His Arg Gln Ala Arg Arg Met Arg Gln Arg Lys Ile Gln 
    50                  55                  60                  


Arg Leu Asn Leu Leu Met Glu Leu Phe Asp Val Glu Ile Ser Lys Val 
65                  70                  75                  80  


Asp Glu Ser Phe Phe Ile Arg Lys Lys Glu Ser Asp Leu His Tyr Glu 
                85                  90                  95      


Asp Lys Ser Gln Asp Ser Arg Tyr Ala Leu Phe Asn Asp Lys Glu Phe 
            100                 105                 110         


Asn Asp Lys Asp Tyr His Asn Lys Tyr Pro Thr Ile Phe His Leu Ile 
        115                 120                 125             


Met Asp Leu Ile Glu Asn Asp Glu Lys Lys Asp Ile Arg Leu Leu Tyr 
    130                 135                 140                 


Leu Ala Cys His Tyr Leu Ile Lys Asn Arg Gly His Phe Ile Phe Glu 
145                 150                 155                 160 


Gly Gln Lys Phe Asp Val Asn Ser Ser Leu Asn Asn Asn Ile Asn Lys 
                165                 170                 175     


Leu Lys Ser His Leu Asp Gln Phe Tyr Asn Ile Cys Leu Asp Phe Asp 
            180                 185                 190         


Asn Asp Lys Leu Ile Glu Ile Leu Val Asn Gln Asn Leu Asn Ile Ser 
        195                 200                 205             


Glu Lys Ser Lys Lys Ile Lys Glu Leu Leu Arg Lys Thr Asn Leu Glu 
    210                 215                 220                 


Val Gly Ile Ala Asn Leu Ile Ala Gly Gly Ser Ile Lys Leu Ser Asn 
225                 230                 235                 240 


Met Phe Asp Asp Asp Glu Leu Lys Asn Leu Asp Tyr Asn Ser Leu Ser 
                245                 250                 255     


Phe Lys Asn Ser Asn Phe Asp Glu Gly Arg Glu Leu Phe Glu Glu Val 
            260                 265                 270         


Leu Glu Asp Arg Phe Glu Leu Val Glu Ile Leu Lys Asp Ile His Asp 
        275                 280                 285             


Ala Ser Val Leu Glu Thr Met Leu Ser Ser Ala Ser Ile Ser Pro Asp 
    290                 295                 300                 


Gly Gly Lys Tyr Ile Ser Ser Ser Met Ile Asn Ser Tyr Asn Lys His 
305                 310                 315                 320 


Lys Arg Asp Leu Lys Leu Leu Lys Lys Ile Ile Lys Lys Tyr Lys Lys 
                325                 330                 335     


Ser Glu Tyr Asp Asn Ile Phe Arg Asp Glu Asn Ile Lys Asn Asn Tyr 
            340                 345                 350         


Leu Ser Tyr Thr Arg Thr Gly Ile Asn Lys Asn Lys Lys Val Gln Ala 
        355                 360                 365             


Glu Asp Asn Thr Asp Ser Asp Gly Phe Tyr Lys Tyr Ile Val Lys Ile 
    370                 375                 380                 


Leu Lys Asp Ile Lys Glu Asn Asp Ser Asp Glu Asp Ile Lys Tyr Ile 
385                 390                 395                 400 


Leu Ser Glu Ile Asp Lys Lys Asn Phe Val Pro Lys Gln Arg Thr Lys 
                405                 410                 415     


Glu Asn Ser Val Ile Pro Tyr Gln Leu Arg Glu Ile Glu Leu Arg Lys 
            420                 425                 430         


Ile Ile Asp Asn Gln Ser Lys Tyr His Lys Phe Leu Asn Glu Val Asp 
        435                 440                 445             


Glu Lys Gly Ile Ser Val Lys Glu Lys Ile Ile Ser Leu Leu Thr Phe 
    450                 455                 460                 


Arg Ile Pro Tyr Tyr Ile Gly Pro Leu Asn Pro Ser Tyr Asn Glu Glu 
465                 470                 475                 480 


Lys Asn Phe Thr Thr Ser Trp Val Lys Arg Leu Ala Lys Gly Lys Val 
                485                 490                 495     


Thr Pro Trp Asn Phe Glu Asp Met Val Asp Ile Asp Ala Ser Arg Glu 
            500                 505                 510         


Ala Phe Ile Glu Asn Lys Leu Asn Lys Cys Ser Phe Leu Leu Asp Glu 
        515                 520                 525             


Thr Val Leu Pro Lys Asp Ser Leu Leu Tyr Gln Glu Tyr Met Val Leu 
    530                 535                 540                 


Asn Glu Leu Asn Asn Leu Lys Ile Asn Gly Gln Ser Ile Asn Thr Asp 
545                 550                 555                 560 


Leu Lys Lys Ser Ile Tyr Glu Glu Leu Phe Lys Lys Tyr Lys Lys Val 
                565                 570                 575     


Thr Arg Lys Arg Leu Ile Ser Tyr Ile Lys Glu Lys Glu Asn Met Ser 
            580                 585                 590         


Gly Asp Ile Val Ile Thr Gly Ile Asp Gly Asp Phe Lys Gln Gly Leu 
        595                 600                 605             


Lys Ser Tyr Ile Ala Phe Lys Asp Ile Ile Gly Glu Lys Ile Asp Asp 
    610                 615                 620                 


Asp Ile Tyr Arg Lys Glu Val Glu Lys Ile Ile Arg Asp Ile Ser Leu 
625                 630                 635                 640 


Tyr Gly Asp Asp Lys Ser Phe Ile Gln Lys Lys Ile Lys Asn Glu Asn 
                645                 650                 655     


Lys Leu Asp Leu Ser Asp Asp Gln Ile Ser Lys Ile Ala Lys Leu Lys 
            660                 665                 670         


Phe Lys Asp Trp Gly Arg Phe Ser Lys Lys Leu Leu Val Gly Ile Lys 
        675                 680                 685             


Ala Ser Asp Lys Asn Thr Gly Glu Ile Asp Asn Ile Ile Gly Phe Met 
    690                 695                 700                 


Arg Asn Tyr Asn Tyr Asn Ile Met Gln Leu Met Ala Asn Val Phe Thr 
705                 710                 715                 720 


Phe Lys Asp Glu Ile Glu Lys Leu Asn Ser Lys Tyr Tyr Thr Asp Glu 
                725                 730                 735     


Lys Ile Asn Ile Asp Tyr Leu Asp Asp Leu Tyr Leu Ser Ser Pro Ala 
            740                 745                 750         


Lys Arg Met Leu Trp Gln Ser Phe Gln Ile Val Asp Glu Ile Lys Asn 
        755                 760                 765             


Ile Lys Asn Ser Asp Pro Lys Lys Ile Phe Ile Glu Met Ala Arg Ser 
    770                 775                 780                 


Lys Glu Asp Lys Pro Thr Arg Lys Met Ser Arg Lys Ser Arg Leu Glu 
785                 790                 795                 800 


Lys Leu Tyr Thr Asp Ser Lys Lys Gln Phe Ile Lys Leu Phe Gly Pro 
                805                 810                 815     


Asp Glu Tyr Asp Lys Leu Asn Asn Glu Ile Lys Asn Lys Ser Glu Ser 
            820                 825                 830         


Asp Phe Arg Trp Asp Asn Leu Tyr Leu Tyr Tyr Thr Gln Phe Gly Arg 
        835                 840                 845             


Cys Met Tyr Ser Leu Asp Pro Ile Asp Leu Glu Glu Leu Ser Asn Lys 
    850                 855                 860                 


Asn Leu Tyr Asp Gln Asp His Ile Tyr Pro Lys Ser Lys Ile Tyr Asp 
865                 870                 875                 880 


Asp Ser Ile Glu Asn Arg Val Leu Val Lys Lys Gln Leu Asn Leu Asp 
                885                 890                 895     


Lys Ser Asn Glu Tyr Pro Ile Pro Asp Arg Val Leu Asn Lys Asp Lys 
            900                 905                 910         


Asn Lys Leu Leu Ala Phe Trp Lys Met Leu Asn Glu Lys Glu Leu Ile 
        915                 920                 925             


Gly Asp Lys Lys Tyr Ala Arg Leu Ile Arg Lys Ser Pro Phe Thr Asp 
    930                 935                 940                 


Glu Glu Leu Gly Asp Phe Ile Ala Arg Gln Leu Val Glu Thr Arg Gln 
945                 950                 955                 960 


Ala Thr Lys Glu Thr Ala Asn Met Leu Lys Arg Leu Cys Pro Asp Ser 
                965                 970                 975     


Lys Ile Val Tyr Val Lys Ala Lys Asn Val Ser Asp Phe Arg Arg Lys 
            980                 985                 990         


Phe Asp Ile Leu Lys Cys Arg Ser  Ile Asn Asp Leu His  His Ala His 
        995                 1000                 1005             


Asp Ala  Tyr Leu Asn Ile Val  Val Gly Asn Val Phe  Asp Thr Lys 
    1010                 1015                 1020             


Phe Thr  Ser Asn Pro Leu Asn  Phe Ile Lys Asn Asn  Ser Lys Asn 
    1025                 1030                 1035             


Arg Ser  Tyr Asn Leu Glu Lys  Ile Tyr Asp Tyr Asp  Val Ile Arg 
    1040                 1045                 1050             


Asn Glu  Lys Ile Ala Trp Leu  Ala Glu Arg Lys Glu  Glu Asn Gln 
    1055                 1060                 1065             


Asp Gly  Ser Ile Ala Thr Val  Leu Lys Asn Leu Ser  Lys Asn Asp 
    1070                 1075                 1080             


Ile Arg  Val Thr Arg Arg Thr  Tyr Ile Lys Cys Glu  Asp Leu Phe 
    1085                 1090                 1095             


Asp Glu  Asn Ile Val Arg Lys  Gly Asn Gly Lys Phe  Pro Ile Lys 
    1100                 1105                 1110             


Glu Asn  Asn Asn Lys Ser Asp  Thr Asn Lys Tyr Gly  Gly Tyr Ser 
    1115                 1120                 1125             


Gly Ile  Lys Asn Ala Tyr Phe  Val Leu Leu Glu Asp  Glu Lys His 
    1130                 1135                 1140             


Asn Arg  Ile Leu Glu Ala Ile  Pro Ser Phe Ile Tyr  Lys Lys Glu 
    1145                 1150                 1155             


Lys Asn  Gly Glu Lys Gly Ser  Val Ile Asn Tyr Leu  Gln Asn Ile 
    1160                 1165                 1170             


Leu Gly  Ile Lys Ser Ala Lys  Ile Leu Arg Asp Lys  Ile Lys Ile 
    1175                 1180                 1185             


Gly Ser  Leu Leu Lys Ile Asp  Lys Phe Pro Tyr Asn  Leu Ala Gly 
    1190                 1195                 1200             


Lys Ser  Gly Asn Gly Ile Leu  Ile Ser Gly Gly Val  Gln Leu Ile 
    1205                 1210                 1215             


Leu Asp  Lys Asn Thr Ser Lys  Tyr Ile Lys Lys Ile  Glu Asn Tyr 
    1220                 1225                 1230             


Lys Tyr  Lys Leu Asp Glu Asn  Lys Asp Tyr Gln Ile  Asn Ile Phe 
    1235                 1240                 1245             


Asp Lys  Leu Ser Lys Glu Glu  Asn Ile Lys Leu Phe  Asp Leu Phe 
    1250                 1255                 1260             


Val Asp  Lys Phe Glu Asn Ser  Ile Tyr Lys Asn Arg  Val Asn Ile 
    1265                 1270                 1275             


Lys Leu  Lys Glu Ile Lys Leu  Ala Arg Pro Lys Phe  Glu His Leu 
    1280                 1285                 1290             


Ser Ile  Glu Glu Gln Ile Lys  Thr Leu Thr Gln Met  Leu Ile Leu 
    1295                 1300                 1305             


Phe Gly  Arg Glu Asn Asn Ala  Val Asn Leu Glu Tyr  Ile Gly Leu 
    1310                 1315                 1320             


Pro Lys  Asn Thr Gly Lys Thr  Lys Ile Asn Lys Lys  Ile Asn Asn 
    1325                 1330                 1335             


Lys Asp  Ile Lys Ile Ile Asn  Gln Ser Ile Thr Gly  Leu Tyr Glu 
    1340                 1345                 1350             


Thr Glu  Glu Asp Leu Ala Asn  Ile 
    1355                 1360     


<210> 65
<211> 1552
<212> PRT
<213> Anaerophaga sp.


<220>
<223> Anaerophaga sp. HS1

<400> 65
Met Phe Ser Gln Arg Asn Asn Pro Tyr Cys Glu Leu Leu Gln Asn Val 
1               5                   10                  15      


Lys Gln Leu Tyr Lys Glu Lys Phe Gly Lys Thr Asn Gln Val Asp Asn 
            20                  25                  30          


Ser Ile Ile Tyr Gly Phe Met Lys Arg Ile Leu Gly Leu Asp Leu Gly 
        35                  40                  45              


Thr Asn Ser Ile Gly Trp Ala Leu Val Glu Asn Asp Glu Asn Asp Arg 
    50                  55                  60                  


Lys Gly Lys Ile Ile Gly Met Gly Ser Arg Ile Ile Pro Met Asp Met 
65                  70                  75                  80  


Ser Glu Leu Asp Asn Phe Asn Lys Gly Ala Ser Ile Ser Lys Thr Ala 
                85                  90                  95      


Glu Arg Thr Arg Leu Arg Met Thr Arg Arg Leu Arg Glu Arg His Leu 
            100                 105                 110         


Leu Arg Arg Ala Arg Leu His Arg Ile Leu Asn Ile Met Gly Phe Leu 
        115                 120                 125             


Pro Glu His Tyr Arg Asn Ser Ile Asp Phe Ile Asp Lys Lys Gly Cys 
    130                 135                 140                 


Phe Phe Glu Gly Gln Glu Pro Lys Ile Ala Tyr Lys Pro Asp Lys Asn 
145                 150                 155                 160 


Ser Glu Gln Phe Cys Phe Leu Phe Thr Ser Ser Phe His Glu Met Leu 
                165                 170                 175     


Glu Asp Phe Arg Lys Phe Gln Pro Glu Leu Ile Gln Asn Arg Lys Lys 
            180                 185                 190         


Val Pro Tyr Asp Trp Thr Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Thr 
        195                 200                 205             


Gln Lys Ile Ser Lys Glu Glu Leu Ala Trp Ile Ile Leu Asn Phe Asn 
    210                 215                 220                 


Thr Lys Arg Gly Tyr Tyr His Leu Arg Gly Glu Asp Glu Asp Asn Gln 
225                 230                 235                 240 


Asp Asn Lys Lys Ile Lys Glu Phe Arg Ala Leu Lys Val Val Asn Val 
                245                 250                 255     


Thr Glu Arg Glu Gly Ala Asn Ser Ser Gly Lys Lys Trp Tyr Asp Met 
            260                 265                 270         


Glu Leu Glu Asn Gly Trp Val Tyr Ser Arg Gln Ser Asn Leu Pro Pro 
        275                 280                 285             


Asn Leu Glu Gly Lys Thr Ile Glu Leu Ile Val Ser Tyr Thr Leu Asp 
    290                 295                 300                 


Asn Asn Gly Asn Ile Lys Lys Asp Lys Asn Gly Lys Glu Lys Tyr Ser 
305                 310                 315                 320 


Leu Ser Met Pro Gly Glu Glu Asp Trp Asn Leu Val Lys Ile Lys Thr 
                325                 330                 335     


Glu Asn Asp Leu Lys Thr Ser Lys Lys Ser Val Gly Glu Tyr Ile Tyr 
            340                 345                 350         


Asp His Leu Leu Lys Asn Pro Asp Gln Lys Ile Arg Gly Lys Leu Ile 
        355                 360                 365             


Ser Thr Ile Glu Arg Lys Phe Tyr Lys Glu Glu Leu Ser Arg Ile Leu 
    370                 375                 380                 


Lys Thr Gln Met Asn Phe Tyr Glu Glu Leu Lys Asn Arg Glu Leu Tyr 
385                 390                 395                 400 


Gln Lys Cys Val Glu Glu Leu Tyr Pro Asn Asn Lys Ser His Gln Gln 
                405                 410                 415     


Thr Leu Leu Gln Lys Asp Phe Ile His Leu Ile Val Glu Asp Ile Ile 
            420                 425                 430         


Phe Tyr Gln Arg Pro Leu Lys Ser Lys Arg Ala Phe Val Asn Asn Cys 
        435                 440                 445             


Pro Leu Glu Tyr Arg Val Tyr Val Asp Lys Lys Ser Gly Glu Leu Ile 
    450                 455                 460                 


Lys Ser Gly Val Lys Cys Ile Pro Lys Ser His Pro Leu Phe Gln Glu 
465                 470                 475                 480 


Phe Arg Leu Trp Gln Tyr Val Arg Asn Leu Arg Ile Tyr Glu Arg Glu 
                485                 490                 495     


Arg Met Val Asn Gly Arg Leu Met Val Asn Val Asp Val Thr Asn Glu 
            500                 505                 510         


Leu Leu Pro Asp Glu Glu His Ile Val Arg Leu Phe Asp Leu Leu Asn 
        515                 520                 525             


Asp Arg Lys Ser Phe Lys Gln Asp Asp Val Leu Arg Phe Val Gly Ile 
    530                 535                 540                 


Lys Ser Pro Lys Asp Arg Lys Arg Tyr Ser Trp Asn Tyr Pro Glu Asp 
545                 550                 555                 560 


Lys Glu Leu Pro Gly Asn Glu Thr Arg His Leu Ile Leu Ala Trp Leu 
                565                 570                 575     


Lys Lys Val Asp Gly Val Pro Glu Asp Trp Leu Asp Pro Glu Lys Leu 
            580                 585                 590         


Lys Ala Leu Trp His Leu Leu Tyr Ser Val Thr Asp Arg Glu Glu Ile 
        595                 600                 605             


Ile Lys Gly Leu His Ser Phe Ala Lys Lys Tyr Glu Leu Pro Asp Thr 
    610                 615                 620                 


Phe Val Glu His Phe Lys Lys Ile Pro Arg Leu Glu Arg Glu Tyr Gly 
625                 630                 635                 640 


Ser Phe Ser Glu Lys Ala Ile Lys Lys Leu Leu Pro Leu Met Arg Met 
                645                 650                 655     


Gly Lys Tyr Trp Lys Ala Glu Glu Ile Pro Ala Asp Leu Leu Glu Lys 
            660                 665                 670         


Ala Gln Lys Ile Ile Asp Ala Glu Ala Asp Asp Arg Ile Ser Asp Glu 
        675                 680                 685             


Val Arg Glu Lys Leu Leu His Leu Lys Asp Ile Ser Gln Leu Lys Gly 
    690                 695                 700                 


Leu Pro Leu Trp Gln Ala Ser Tyr Leu Val Tyr Gly Arg His Ser Glu 
705                 710                 715                 720 


Thr Gly Glu Val Val Lys Trp Arg Thr Ser Glu Asp Leu Glu Lys Tyr 
                725                 730                 735     


Ile Leu Gln Phe Lys Gln His Ser Leu Arg Asn Pro Val Val Glu Gln 
            740                 745                 750         


Val Ile Leu Glu Ala Leu Arg Val Val Lys Asp Ile Trp Glu His Tyr 
        755                 760                 765             


Gly Glu Gly Lys Glu Gly Phe Phe Asn Glu Ile His Val Glu Ile Gly 
    770                 775                 780                 


Arg Glu Leu Lys Asn Pro Ala Asp Lys Arg Lys Lys Ile Thr Ser Gln 
785                 790                 795                 800 


Ile Gln Glu Asn Glu Asn Thr Asn Leu Arg Ile Lys Ala Leu Leu Glu 
                805                 810                 815     


Glu Leu Phe Asn Asp Pro Ser Val Lys Asn Val Arg Pro Tyr Ser Pro 
            820                 825                 830         


Ala Gln Gln Glu Ile Leu Arg Ile Tyr Glu Asp Gly Val Leu Asn Gly 
        835                 840                 845             


Gln Lys Glu Ile Pro Asp Asp Ile Leu Lys Ile Ser Lys Met Ala Arg 
    850                 855                 860                 


Pro Ser Lys Ser Gln Leu Val Lys Tyr Lys Leu Trp Leu Glu Gln Lys 
865                 870                 875                 880 


Tyr Arg Ser Pro Tyr Thr Gly Glu Ile Ile Pro Leu Ser Gln Leu Phe 
                885                 890                 895     


Thr Ser Ala Tyr Glu Ile Glu His Ile Ile Pro Gln Ala Arg Tyr Phe 
            900                 905                 910         


Asp Asp Ser Phe Ser Asn Lys Val Ile Cys Glu Ala Glu Val Asn Arg 
        915                 920                 925             


Glu Lys Gly His Gln Leu Ala Phe Glu Phe Ile Thr Lys Arg Gly Gly 
    930                 935                 940                 


Asp Glu Ile Glu Leu Asn Phe Gly Lys Lys Val Thr Ile Leu Asn Val 
945                 950                 955                 960 


Glu Glu Tyr Gln Lys Phe Val Lys Asp His Tyr Gly Arg Ser Leu Arg 
                965                 970                 975     


Ser Leu Ser Lys Met Arg Lys Leu Leu Met Glu Asp Ile Pro Asp Asp 
            980                 985                 990         


Phe Ile Asp Arg Gln Leu Asn Asp  Ser Arg Tyr Ile Ser  Lys Val Val 
        995                 1000                 1005             


Arg Asn  Leu Leu Ser Asn Ile  Val Arg Ala Glu Asp  Glu Asn Ser 
    1010                 1015                 1020             


Leu Val  Ser Lys His Leu Ile  Thr Cys Thr Gly Gly  Val Thr Thr 
    1025                 1030                 1035             


Arg Leu  Lys His Glu Trp Gly  Leu Asn Asp Val Trp  Asn Glu Leu 
    1040                 1045                 1050             


Ile Thr  Pro Arg Phe Val Arg  Leu Asn Lys Met Gly  Lys Glu Lys 
    1055                 1060                 1065             


Phe Gly  Glu Trp Ile Asn Lys  Lys Gly Lys Gln Val  Phe Gln Ile 
    1070                 1075                 1080             


Gln Met  Pro Leu Glu Leu Gln  Lys Gly Phe Asn Lys  Lys Arg Ile 
    1085                 1090                 1095             


Asp His  Arg His His Ala Leu  Asp Ala Leu Val Val  Ala Cys Ala 
    1100                 1105                 1110             


Ser Arg  Ser His Val Asn Tyr  Leu Asn Asn Asp Ser  Ala Arg Ala 
    1115                 1120                 1125             


Asn Ala  Ser Glu Thr Arg Tyr  Asp Leu Arg Asn Lys  Leu Cys Tyr 
    1130                 1135                 1140             


Lys Asp  Lys Thr Asp Ser Asn  Gly Asn Tyr Arg Trp  Lys Phe Tyr 
    1145                 1150                 1155             


Lys Pro  Trp Glu Ser Phe Thr  Glu Glu Ala Lys Asn  Arg Leu Ala 
    1160                 1165                 1170             


Gly Thr  Val Val Ser Phe Lys  Ser Asn Arg Arg Ile  Met Thr Arg 
    1175                 1180                 1185             


Ser Ser  Asn Arg Tyr Phe Lys  Trp Val Asp Thr Ser  Glu Gly Lys 
    1190                 1195                 1200             


Lys Lys  Lys Leu Val Arg Gln  Ile Lys Gly Asp Asn  Gln Ala Ile 
    1205                 1210                 1215             


Arg Lys  Pro Leu His Lys Asp  Thr Val Leu Gly Lys  Val Ser Leu 
    1220                 1225                 1230             


Arg Lys  Glu Lys Lys Val Ser  Leu Ser Lys Ala Ile  Asp Leu Trp 
    1235                 1240                 1245             


Glu Ser  Ile Val Asp Lys Pro  Leu Lys Lys Arg Ile  Gln Ser Leu 
    1250                 1255                 1260             


Arg Glu  Gln Gly Tyr Asp Lys  Lys Leu Leu Leu Lys  Tyr Phe Lys 
    1265                 1270                 1275             


Asp Arg  Asn Asn Gln Phe Asn  Gly Gln Asp Ile Ser  Arg Val Asn 
    1280                 1285                 1290             


Ile Tyr  Phe Phe Asp Asn Asn  Leu Ala Ala Arg Arg  Val Thr Leu 
    1295                 1300                 1305             


Asp Ala  Ser Phe Asn Ser Glu  Lys Arg Ile Asp Gly  Ile Thr Asp 
    1310                 1315                 1320             


Ser Gly  Ile Lys Lys Ile Leu  Tyr Ala His Leu Gln  Asn Glu Lys 
    1325                 1330                 1335             


Tyr His  Gly Lys Lys Asp Glu  Lys Gly Asn Glu Ile  Ser Pro Tyr 
    1340                 1345                 1350             


Glu Leu  Ala Phe Ser Pro Glu  Gly Leu Glu Glu Met  Asn Ala Asn 
    1355                 1360                 1365             


Ile Lys  Lys Leu Asn Gly Gly  Lys Pro His Cys Pro  Ile Tyr Lys 
    1370                 1375                 1380             


Val Arg  Leu Ala Glu Thr Ile  Gly Glu Lys Phe Lys  Leu Gly Glu 
    1385                 1390                 1395             


Lys Gly  Asn Lys Asn Lys Lys  Tyr Val Glu Ala Ala  Lys Gly Thr 
    1400                 1405                 1410             


Asn Leu  Phe Phe Ala Val Tyr  Val Asp Glu Lys Gly  Val Arg Ser 
    1415                 1420                 1425             


Phe Glu  Thr Ile Pro Phe Ser  Val Ala Leu Glu Arg  Arg Lys Gln 
    1430                 1435                 1440             


Lys Leu  Ala Val Val Pro Glu  Glu Asn Glu Asn Lys  Glu Lys Leu 
    1445                 1450                 1455             


Leu Phe  Tyr Leu Ser Pro Asn  Asp Leu Val Tyr Val  Pro Asp Glu 
    1460                 1465                 1470             


Asp Glu  Lys Leu Ile Asp Tyr  Arg Gln Leu Ser Ile  Asn Pro Thr 
    1475                 1480                 1485             


Arg Ile  Tyr Lys Met Val Ser  Ser Ser Gly Thr Gln  Cys Phe Phe 
    1490                 1495                 1500             


Ile Pro  His Phe Val Ala Ser  Pro Ile Val Gln Thr  Met Glu Leu 
    1505                 1510                 1515             


Gly Pro  Asn Asn Lys Ser Glu  Arg Ala Trp Asp Gly  Gln Met Ile 
    1520                 1525                 1530             


Lys Asn  Val Cys Tyr Lys Leu  Ser Val Asp Arg Leu  Gly Asn Val 
    1535                 1540                 1545             


Lys Ile  Glu Lys 
    1550         


<210> 66
<211> 1515
<212> PRT
<213> Anaerophaga thermohalophila


<220>
<223> Anaerophaga thermohalophila DSM 12881

<400> 66
Met Lys Arg Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Glu Ser Asp Glu Glu Gln Lys Ser Gly Lys Ile Gln Gly 
            20                  25                  30          


Ile Gly Ser Arg Ile Ile Pro Met Asp Gln Asn Glu Leu Asp Asn Phe 
        35                  40                  45              


Asn Lys Gly Asn Thr Val Ser Gln Thr Ala Glu Arg Thr Arg Leu Arg 
    50                  55                  60                  


Met Val Arg Arg Leu Arg Glu Arg His Leu Leu Arg Arg Glu Arg Leu 
65                  70                  75                  80  


His Arg Val Leu Lys Glu Ile Gly Phe Leu Pro Glu His Tyr Leu Glu 
                85                  90                  95      


Gln Ile Asp Phe Thr Glu Lys Pro Gly Gly Phe Leu Pro Gly Lys Glu 
            100                 105                 110         


Pro Lys Ile Ala Tyr Lys Pro Asp Asn Phe Lys Asp Lys Tyr Asp Phe 
        115                 120                 125             


Leu Phe Gln Asp Ser Tyr His Glu Met Leu Ser Asp Phe Gln Asp Lys 
    130                 135                 140                 


Asn Pro Glu Phe Ile Gln Lys Arg Lys Lys Val Pro Gln Asp Trp Thr 
145                 150                 155                 160 


Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Thr Ala Lys Ile Thr Lys Glu 
                165                 170                 175     


Glu Leu Ala Trp Ile Ile Leu Asn Phe Asn Gln Lys Arg Gly Tyr Tyr 
            180                 185                 190         


Gln Leu Arg Gly Glu Asp Glu Asp Val Ala Lys Asn Thr Lys Lys Glu 
        195                 200                 205             


Glu Phe His Ala Leu Lys Val Val Lys Val Lys Glu Arg Glu Asp Ser 
    210                 215                 220                 


Glu Gly Ala Ser Gly Lys Trp Tyr Asp Ile Glu Leu Glu Asn Gly Trp 
225                 230                 235                 240 


Val Tyr Pro Arg Gln Ser Asn Ile Arg Pro Asp Trp Glu Gly Lys Ile 
                245                 250                 255     


Leu Glu Leu Ile Val Thr Tyr Asn Leu Asp Lys Asp Gly Asn Ile Lys 
            260                 265                 270         


Thr Asp Lys Glu Gly Asn Glu Lys Arg Ser Phe Arg Met Pro Asn Lys 
        275                 280                 285             


Asp Asp Trp Thr Leu Arg Lys Lys Arg Thr Glu Asn Glu Ile Glu Lys 
    290                 295                 300                 


Ser Gly Lys Thr Val Gly Glu Tyr Ile Tyr Asp Asn Leu Leu Asp Ala 
305                 310                 315                 320 


Pro Asp Leu Lys Ile Arg Gly Lys Leu Val Ser Thr Ile Glu Arg Lys 
                325                 330                 335     


Tyr Tyr Arg Ser Glu Leu Glu Gln Ile Leu Thr Ala Gln Lys Lys Tyr 
            340                 345                 350         


His Pro Glu Leu Ser Asn Ser Glu Leu Phe Asn Lys Cys Ile Ser Asn 
        355                 360                 365             


Leu Tyr Pro Asn Asn Asp Ile His Arg Lys Ala Leu Leu Ser Lys Asp 
    370                 375                 380                 


Phe Val His Leu Ile Ile Asn Asp Ile Ile Phe Tyr Gln Arg Pro Leu 
385                 390                 395                 400 


Lys Ser Lys Arg Ser Thr Val Ser Asn Cys Pro Leu Glu Tyr Arg Val 
                405                 410                 415     


Tyr Val Asp Lys Val Thr Gly Glu Lys Lys Lys Val Pro Leu Lys Cys 
            420                 425                 430         


Ile Pro Lys Ser His Pro Leu Tyr Gln Glu Phe Arg Leu Trp Gln Tyr 
        435                 440                 445             


Val Lys Asn Leu Arg Leu Phe Glu Lys Glu Arg Phe Glu Asn Gly Arg 
    450                 455                 460                 


Leu Leu Thr Asn Val Asp Val Thr Glu Gln Phe Leu Pro Asp Glu Asp 
465                 470                 475                 480 


Lys Tyr Val Glu Leu Phe Glu Phe Leu Asn Gly Arg Lys Thr Phe Lys 
                485                 490                 495     


Gln Asp Asp Ile Leu Lys Phe Ala Gly Ile Lys Ser Ala Lys Asp Arg 
            500                 505                 510         


Val Lys Tyr Tyr Trp Asn Tyr Pro Gln Glu Lys Glu Tyr Pro Gly Asn 
        515                 520                 525             


Glu Thr Arg Tyr Leu Ile Glu Ser Arg Leu Lys Lys Ile Glu Asn Val 
    530                 535                 540                 


Pro Asp Glu Trp Leu Asn Tyr Glu Lys Ile Glu Glu Leu Trp His Leu 
545                 550                 555                 560 


Leu Tyr Ser Val Thr Asp Lys Val Glu Ile Glu Lys Gly Leu Gln Ser 
                565                 570                 575     


Phe Ala Ala Lys Tyr Gln Leu Pro Asp Leu Phe Val Glu Val Phe Lys 
            580                 585                 590         


Gly Phe Pro Arg Met Glu Arg Glu Tyr Gly Ala Phe Ser Lys Lys Ala 
        595                 600                 605             


Ile Lys Lys Leu Leu Pro Leu Met Arg Met Gly Lys Tyr Trp Lys Leu 
    610                 615                 620                 


Glu Asn Ile Asn Pro Asp Leu Ile Glu Lys Val Gln Lys Ile Ile Asp 
625                 630                 635                 640 


Gly Glu Ala Asp Asp Asn Ile Asn Asp Gly Ile Arg Glu Arg Phe Ser 
                645                 650                 655     


Glu Ile Asn Glu Met Ser Asp Leu Arg Gly Met Pro Leu Trp Lys Ala 
            660                 665                 670         


Ser Tyr Leu Val Tyr Gly Arg His Ser Glu Ala Ala Glu Val Ile Arg 
        675                 680                 685             


Trp Arg Thr Ser Ala Asp Leu Asp Gln Tyr Ile Lys Asp Phe Lys Gln 
    690                 695                 700                 


His Ala Leu Arg Asn Pro Ile Val Glu Gln Val Val Leu Glu Ala Leu 
705                 710                 715                 720 


Arg Val Val Lys Asp Val Trp Asn Tyr Phe Gly Glu Gly Arg Glu Lys 
                725                 730                 735     


Phe Phe Asp Glu Ile His Val Glu Ile Gly Arg Asp Leu Lys Asn Pro 
            740                 745                 750         


Ala Asp Lys Arg Gln Lys Ile Ala Asn Gln Ile Gln Glu Asn Glu Asn 
        755                 760                 765             


Thr Asn Leu Arg Ile Lys Ala Leu Leu Val Glu Leu Phe Asn Asp Pro 
    770                 775                 780                 


Glu Val Gln Asn Val Arg Pro Tyr Ser Pro Val Gln Gln Gln Leu Leu 
785                 790                 795                 800 


Lys Ile Tyr Glu Asp Gly Val Leu Asn Ala Glu Arg Asp Ile Pro Asp 
                805                 810                 815     


Asp Ile Gln Lys Ile Ser Arg Met Ala Asn Pro Thr Arg Asn Gln Leu 
            820                 825                 830         


Ile Arg Tyr Lys Leu Trp Leu Glu Gln Lys Tyr Arg Ser Pro Tyr Thr 
        835                 840                 845             


Gly Glu Ile Ile Pro Leu Asn Lys Leu Phe Thr Ser Glu Tyr Glu Val 
    850                 855                 860                 


Glu His Ile Ile Pro Arg Ala Arg Tyr Phe Asp Asp Ser Phe Ser Asn 
865                 870                 875                 880 


Lys Ile Ile Ser Glu Ala Glu Val Asn Arg Lys Lys Asp Arg Met Leu 
                885                 890                 895     


Ala Phe Glu Phe Ile Lys Lys Leu Gly Gly Ser Thr Ile Asp Leu Asn 
            900                 905                 910         


Tyr Gly Lys Lys Val Ser Val Leu Thr Val Glu Glu Tyr Gln Gln Phe 
        915                 920                 925             


Val Lys Asp His Tyr Gly Ile Asn Pro His Ser Arg Leu Lys Met Gln 
    930                 935                 940                 


Lys Leu Leu Met Asp Glu Ile Pro Glu Ser Phe Ile Glu Arg Gln Leu 
945                 950                 955                 960 


Asn Asp Ser Arg Tyr Ile Ser Lys Met Val Arg Asn Leu Leu Ser Asn 
                965                 970                 975     


Ile Val Arg Glu Glu Asn Glu Asn Ser Pro Val Ala Lys Gln Leu Ile 
            980                 985                 990         


Thr Cys Ser Gly Ser Ile Thr Asn  Thr Leu Lys Gln Glu  Trp Gly Leu 
        995                 1000                 1005             


Asn Asp  Val Trp Asn Thr Ile  Ile Thr Pro Arg Phe  Glu Arg Leu 
    1010                 1015                 1020             


Asn Lys  Met Gly Glu Gln Lys  Tyr Gly Glu Trp Val  Asn Lys Glu 
    1025                 1030                 1035             


Gly Lys  Pro Val Phe Gln Ile  Gln Met Pro Leu Glu  Leu Gln Lys 
    1040                 1045                 1050             


Gly Phe  Asn Lys Lys Arg Ile  Asp His Arg His His  Ala Leu Asp 
    1055                 1060                 1065             


Ala Leu  Ile Val Ala Ser Ala  Thr Arg Ser His Val  Asn Tyr Leu 
    1070                 1075                 1080             


Ser Asn  Glu Ala Ala Lys Thr  Asn Ala Lys Asp Thr  Arg Phe Asp 
    1085                 1090                 1095             


Leu Arg  Asn Arg Leu Cys Tyr  Lys Glu Lys Arg Gly  Gln Asn Arg 
    1100                 1105                 1110             


Asn Phe  Thr Trp Arg Phe Tyr  Lys Pro Trp Asn Thr  Phe Thr Glu 
    1115                 1120                 1125             


Asp Ala  Lys Asn Ala Leu Asn  Asp Ile Val Val Ser  Phe Lys Ser 
    1130                 1135                 1140             


Asn His  Arg Val Ile Asn Lys  Ser Thr Asn Arg Tyr  Phe Lys Trp 
    1145                 1150                 1155             


Glu Asn  Leu Pro Gly Gly Met  Lys Lys Lys Arg Leu  Val Arg Gln 
    1160                 1165                 1170             


Glu Lys  Gly Asp Asn Trp Ala  Ile Arg Gln Ser Leu  His Lys Asp 
    1175                 1180                 1185             


Thr Val  Leu Gly Lys Val Ser  Leu Arg Lys Val Lys  Pro Val Ser 
    1190                 1195                 1200             


Leu Ser  Val Ala Leu Asp Ser  Trp Asn Asn Ile Val  Asp Lys Ala 
    1205                 1210                 1215             


Leu Lys  Lys Lys Ile Arg Ser  Leu Lys Asp Gln Gly  Tyr Asp Lys 
    1220                 1225                 1230             


Lys Leu  Met Leu Lys Tyr Phe  Lys Asp Arg Arg Asn  Glu Tyr Asn 
    1235                 1240                 1245             


Gly Glu  Asn Ile Ser Arg Val  Asn Val Tyr Tyr Phe  Asp Glu Glu 
    1250                 1255                 1260             


Met Ala  Ala Arg Arg Val Asp  Leu Asp Thr Ser Phe  Asn Ser Glu 
    1265                 1270                 1275             


Lys Arg  Ile Glu Gly Ile Thr  Asp Ser Gly Ile Lys  Lys Ile Ile 
    1280                 1285                 1290             


Tyr Ala  His Leu Lys Asn Glu  Lys Tyr His Gly Gln  Lys Asp Asp 
    1295                 1300                 1305             


Lys Gly  Lys Asp Ile Ser Pro  Tyr Glu Leu Ala Phe  Ser Pro Glu 
    1310                 1315                 1320             


Gly Ile  Ala Glu Met Asn Ala  Asn Ile Lys Gln Leu  Asn Gly Gly 
    1325                 1330                 1335             


Lys Pro  His Cys Pro Ile Tyr  Lys Val Arg Leu Ala  Glu Pro Val 
    1340                 1345                 1350             


Gly Glu  Lys Phe Gln Leu Gly  Glu Thr Gly Asn Lys  Thr Glu Lys 
    1355                 1360                 1365             


Leu Val  Glu Val Ala Lys Gly  Thr Asn Leu Phe Phe  Gly Val Tyr 
    1370                 1375                 1380             


Ala Asn  Asp Glu Gly Val Arg  Ser Phe Ala Thr Val  Pro Phe Tyr 
    1385                 1390                 1395             


Leu Ala  Val Glu Arg Glu Lys  Gln Gly Leu Pro Ala  Val Pro Gln 
    1400                 1405                 1410             


Glu Asn  Glu Asn Gly Asp Gln  Leu Leu Phe Trp Leu  Ser Pro Asn 
    1415                 1420                 1425             


Asp Leu  Val Tyr Val Pro Ser  Glu Glu Asp Ala His  Phe Ala Asn 
    1430                 1435                 1440             


Pro Lys  Gln Ile Glu Leu Asp  Asn Ser Arg Ile Tyr  Lys Met Val 
    1445                 1450                 1455             


Ser Ser  Thr Gly Thr Gln Cys  Phe Phe Ile Pro His  Phe Val Ala 
    1460                 1465                 1470             


Thr Pro  Ile Val Gln Thr Ile  Glu Leu Gly Pro Asn  Asn Lys Ser 
    1475                 1480                 1485             


Glu Arg  Ala Trp Asp Gly Gln  Met Ile Lys Lys Val  Cys Tyr Lys 
    1490                 1495                 1500             


Leu Ser  Val Asp Arg Leu Gly  Asn Val Glu Ile Glu  
    1505                 1510                 1515 


<210> 67
<211> 1168
<212> PRT
<213> Azospirillum lipoferum

<400> 67
Met Ala Arg Pro Ala Phe Arg Ala Pro Arg Arg Glu His Val Asn Gly 
1               5                   10                  15      


Trp Thr Pro Asp Pro His Arg Ile Ser Lys Pro Phe Phe Ile Leu Val 
            20                  25                  30          


Ser Trp His Leu Leu Ser Arg Val Val Ile Asp Ser Ser Ser Gly Cys 
        35                  40                  45              


Phe Pro Gly Thr Ser Arg Asp His Thr Asp Lys Phe Ala Glu Trp Glu 
    50                  55                  60                  


Cys Ala Val Gln Pro Tyr Arg Leu Ser Phe Asp Leu Gly Thr Asn Ser 
65                  70                  75                  80  


Ile Gly Trp Gly Leu Leu Asn Leu Asp Arg Gln Gly Lys Pro Arg Glu 
                85                  90                  95      


Ile Arg Ala Leu Gly Ser Arg Ile Phe Ser Asp Gly Arg Asp Pro Gln 
            100                 105                 110         


Asp Lys Ala Ser Leu Ala Val Ala Arg Arg Leu Ala Arg Gln Met Arg 
        115                 120                 125             


Arg Arg Arg Asp Arg Tyr Leu Thr Arg Arg Thr Arg Leu Met Gly Ala 
    130                 135                 140                 


Leu Val Arg Phe Gly Leu Met Pro Ala Asp Pro Ala Ala Arg Lys Arg 
145                 150                 155                 160 


Leu Glu Val Ala Val Asp Pro Tyr Leu Ala Arg Glu Arg Ala Thr Arg 
                165                 170                 175     


Glu Arg Leu Glu Pro Phe Glu Ile Gly Arg Ala Leu Phe His Leu Asn 
            180                 185                 190         


Gln Arg Arg Gly Tyr Lys Pro Val Arg Thr Ala Thr Lys Pro Asp Glu 
        195                 200                 205             


Glu Ala Gly Lys Val Lys Glu Ala Val Glu Arg Leu Glu Ala Ala Ile 
    210                 215                 220                 


Ala Ala Ala Gly Ala Pro Thr Leu Gly Ala Trp Phe Ala Trp Arg Lys 
225                 230                 235                 240 


Thr Arg Gly Glu Thr Leu Arg Ala Arg Leu Ala Gly Lys Gly Lys Glu 
                245                 250                 255     


Ala Ala Tyr Pro Phe Tyr Pro Ala Arg Arg Met Leu Glu Ala Glu Phe 
            260                 265                 270         


Asp Thr Leu Trp Ala Glu Gln Ala Arg His His Pro Asp Leu Leu Thr 
        275                 280                 285             


Ala Glu Ala Arg Glu Ile Leu Arg His Arg Ile Phe His Gln Arg Pro 
    290                 295                 300                 


Leu Lys Pro Pro Pro Val Gly Arg Cys Thr Leu Tyr Pro Asp Asp Gly 
305                 310                 315                 320 


Arg Ala Pro Arg Ala Leu Pro Ser Ala Gln Arg Leu Arg Leu Phe Gln 
                325                 330                 335     


Glu Leu Ala Ser Leu Arg Val Ile His Leu Asp Leu Ser Glu Arg Pro 
            340                 345                 350         


Leu Thr Pro Ala Glu Arg Asp Arg Ile Val Ala Phe Val Gln Gly Arg 
        355                 360                 365             


Pro Pro Lys Ala Gly Arg Lys Pro Gly Lys Val Gln Lys Ser Val Pro 
    370                 375                 380                 


Phe Glu Lys Leu Arg Gly Leu Leu Glu Leu Pro Pro Gly Thr Gly Phe 
385                 390                 395                 400 


Ser Leu Glu Ser Asp Lys Arg Pro Glu Leu Leu Gly Asp Glu Thr Gly 
                405                 410                 415     


Ala Arg Ile Ala Pro Ala Phe Gly Pro Gly Trp Thr Ala Leu Pro Leu 
            420                 425                 430         


Glu Glu Gln Asp Ala Leu Val Glu Leu Leu Leu Thr Glu Ala Glu Pro 
        435                 440                 445             


Glu Arg Ala Ile Ala Ala Leu Thr Ala Arg Trp Ala Leu Asp Glu Ala 
    450                 455                 460                 


Thr Ala Ala Lys Leu Ala Gly Ala Thr Leu Pro Asp Phe His Gly Arg 
465                 470                 475                 480 


Tyr Gly Arg Arg Ala Val Ala Glu Leu Leu Pro Val Leu Glu Arg Glu 
                485                 490                 495     


Thr Arg Gly Asp Pro Asp Gly Arg Val Arg Pro Ile Arg Leu Asp Glu 
            500                 505                 510         


Ala Val Lys Leu Leu Arg Gly Gly Lys Asp His Ser Asp Phe Ser Arg 
        515                 520                 525             


Glu Gly Ala Leu Leu Asp Ala Leu Pro Tyr Tyr Gly Ala Val Leu Glu 
    530                 535                 540                 


Arg His Val Ala Phe Gly Thr Gly Asn Pro Ala Asp Pro Glu Glu Lys 
545                 550                 555                 560 


Arg Val Gly Arg Val Ala Asn Pro Thr Val His Ile Ala Leu Asn Gln 
                565                 570                 575     


Leu Arg His Leu Val Asn Ala Ile Leu Ala Arg His Gly Arg Pro Glu 
            580                 585                 590         


Glu Ile Val Ile Glu Leu Ala Arg Asp Leu Lys Arg Ser Ala Glu Asp 
        595                 600                 605             


Arg Arg Arg Glu Asp Lys Arg Gln Ala Asp Asn Gln Lys Arg Asn Glu 
    610                 615                 620                 


Glu Arg Lys Arg Leu Ile Leu Ser Leu Gly Glu Arg Pro Thr Pro Arg 
625                 630                 635                 640 


Asn Leu Leu Lys Leu Arg Leu Trp Glu Glu Gln Gly Pro Val Glu Asn 
                645                 650                 655     


Arg Arg Cys Pro Tyr Ser Gly Glu Thr Ile Ser Met Arg Met Leu Leu 
            660                 665                 670         


Ser Glu Gln Val Asp Ile Asp His Ile Leu Pro Phe Ser Val Ser Leu 
        675                 680                 685             


Asp Asp Ser Ala Ala Asn Lys Val Val Cys Leu Arg Glu Ala Asn Arg 
    690                 695                 700                 


Ile Lys Arg Asn Arg Ser Pro Trp Glu Ala Phe Gly His Asp Ser Glu 
705                 710                 715                 720 


Arg Trp Ala Gly Ile Leu Ala Arg Ala Glu Ala Leu Pro Lys Asn Lys 
                725                 730                 735     


Arg Trp Arg Phe Ala Pro Asp Ala Leu Glu Lys Leu Glu Gly Glu Gly 
            740                 745                 750         


Gly Leu Arg Ala Arg His Leu Asn Asp Thr Arg His Leu Ser Arg Leu 
        755                 760                 765             


Ala Val Glu Tyr Leu Arg Cys Val Cys Pro Lys Val Arg Val Ser Pro 
    770                 775                 780                 


Gly Arg Leu Thr Ala Leu Leu Arg Arg Arg Trp Gly Ile Asp Ala Ile 
785                 790                 795                 800 


Leu Ala Glu Ala Asp Gly Pro Pro Pro Glu Val Pro Ala Glu Thr Leu 
                805                 810                 815     


Asp Pro Ser Pro Ala Glu Lys Asn Arg Ala Asp His Arg His His Ala 
            820                 825                 830         


Leu Asp Ala Val Val Ile Gly Cys Ile Asp Arg Ser Met Val Gln Arg 
        835                 840                 845             


Val Gln Leu Ala Ala Ala Ser Ala Glu Arg Glu Ala Ala Ala Arg Glu 
    850                 855                 860                 


Asp Asn Ile Arg Arg Val Leu Glu Gly Phe Lys Glu Glu Pro Trp Asp 
865                 870                 875                 880 


Gly Phe Arg Ala Glu Leu Glu Arg Arg Ala Arg Thr Ile Val Val Ser 
                885                 890                 895     


His Arg Pro Glu His Gly Ile Gly Gly Ala Leu His Lys Glu Thr Ala 
            900                 905                 910         


Tyr Gly Pro Val Asp Pro Pro Glu Glu Gly Phe Asn Leu Val Val Arg 
        915                 920                 925             


Lys Pro Ile Asp Gly Leu Ser Lys Asp Glu Ile Asn Ser Val Arg Asp 
    930                 935                 940                 


Pro Arg Leu Arg Arg Ala Leu Ile Asp Arg Leu Ala Ile Arg Arg Arg 
945                 950                 955                 960 


Asp Ala Asn Asp Pro Ala Thr Ala Leu Ala Lys Ala Ala Glu Asp Leu 
                965                 970                 975     


Ala Ala Gln Pro Ala Ser Arg Gly Ile Arg Arg Val Arg Val Leu Lys 
            980                 985                 990         


Lys Glu Ser Asn Pro Ile Arg Val  Glu His Gly Gly Asn  Pro Ser Gly 
        995                 1000                 1005             


Pro Arg  Ser Gly Gly Pro Phe  His Lys Leu Leu Leu  Ala Gly Glu 
    1010                 1015                 1020             


Val His  His Val Asp Val Ala  Leu Arg Ala Asp Gly  Arg Arg Trp 
    1025                 1030                 1035             


Val Gly  His Trp Val Thr Leu  Phe Glu Ala His Gly  Gly Arg Gly 
    1040                 1045                 1050             


Ala Asp  Gly Ala Ala Ala Pro  Pro Arg Leu Gly Asp  Gly Glu Arg 
    1055                 1060                 1065             


Phe Leu  Met Arg Leu His Lys  Gly Asp Cys Leu Lys  Leu Glu His 
    1070                 1075                 1080             


Lys Gly  Arg Val Arg Val Met  Gln Val Val Lys Leu  Glu Pro Ser 
    1085                 1090                 1095             


Ser Asn  Ser Val Val Val Val  Glu Pro His Gln Val  Lys Thr Asp 
    1100                 1105                 1110             


Arg Ser  Lys His Val Lys Ile  Ser Cys Asp Gln Leu  Arg Ala Arg 
    1115                 1120                 1125             


Gly Ala  Arg Arg Val Thr Val  Asp Pro Leu Gly Arg  Val Arg Val 
    1130                 1135                 1140             


His Ala  Pro Gly Ala Arg Val  Gly Ile Gly Gly Asp  Ala Gly Arg 
    1145                 1150                 1155             


Thr Ala  Met Glu Pro Ala Glu  Asp Ile Ser 
    1160                 1165             


<210> 68
<211> 1068
<212> PRT
<213> Bacillus cereus


<220>
<223> Bacillus cereus BAG4X12-1

<400> 68
Met Arg Tyr Val Leu Gly Leu Asp Ile Gly Ile Ala Ser Cys Gly Trp 
1               5                   10                  15      


Ala Val Ile Asn Gln Glu Lys Glu Arg Ile Glu Asp Leu Gly Val Arg 
            20                  25                  30          


Ile Phe Asp Lys Ala Glu Asn Pro Lys Asp Gly Lys Ser Leu Ala Ala 
        35                  40                  45              


Pro Arg Arg Asp Ala Arg Ser Thr Arg Arg Thr Leu Arg Arg Lys Lys 
    50                  55                  60                  


His Arg Met Gln Arg Ile Lys Ile Leu Leu Val Lys Gln Gly Leu Leu 
65                  70                  75                  80  


Phe Lys Thr Glu Leu Asn His Leu Tyr Glu Ser Ala Thr Glu Phe Asp 
                85                  90                  95      


Val Trp Asn Leu Arg Leu Asp Ala Leu Glu Arg Lys Leu His Pro Lys 
            100                 105                 110         


Glu Phe Ala Arg Val Leu Ile His Leu Ala Lys Arg Arg Gly Phe Lys 
        115                 120                 125             


Ser Asn Arg Lys Glu Thr Thr Leu Ser Glu Asn Gly Gln Ile Leu Glu 
    130                 135                 140                 


Ser Ile Ser Glu Asn Gln Gln Ile Met Glu Gln Gln Asn Tyr Arg Thr 
145                 150                 155                 160 


Val Gly Glu Met Ile Leu Lys Asp Lys Lys Phe Glu Asn His Lys Arg 
                165                 170                 175     


Asn Lys Asp Gly Thr Tyr Ile Gly Thr Val Thr Arg Gln Gln Leu Gln 
            180                 185                 190         


Asp Glu Ile Gln Met Ile Phe His Thr Gln Arg Leu Tyr Lys Asn Asp 
        195                 200                 205             


Tyr Ala Thr Glu Glu Phe Glu Ser Ser Tyr Leu Glu Ile Trp Ala Ser 
    210                 215                 220                 


Gln Arg Pro Tyr Ala Ser Lys Asp Gln Ile Glu Lys Met Ile Gly Tyr 
225                 230                 235                 240 


Cys Thr Leu Glu Pro Lys Glu Lys Arg Thr Pro Lys Ala Ser Trp Ser 
                245                 250                 255     


Phe Gln Tyr Phe Val Ala Leu Gln Thr Ile Asn Asn Leu Arg Leu Ile 
            260                 265                 270         


Ser Lys Asp Lys Ile Glu Glu Leu Ser Phe Glu Glu Lys Lys Gln Ile 
        275                 280                 285             


Met Asn Leu Ala Leu Glu Lys Pro Ile Val Lys Tyr Ile Asp Ile Arg 
    290                 295                 300                 


Lys Leu Leu Ser Ile Pro Asn Asp Phe Gln Phe Asn Ser Leu Ser Tyr 
305                 310                 315                 320 


Ser Ala Asp Thr Val Asp Thr Thr Leu Glu Asn Lys Arg Cys Ile Glu 
                325                 330                 335     


Leu Lys Glu Tyr His Ser Ile Asn Lys Val Tyr Lys Gln Val Tyr Gly 
            340                 345                 350         


Lys Asn Thr Pro Asn Leu Leu Pro Ile Asp Tyr Asp Thr Ile Ala Tyr 
        355                 360                 365             


Gly Leu Thr Ile Phe Lys Asp Asp Lys Asp Ile Leu Glu Tyr Leu Gln 
    370                 375                 380                 


Asn Lys Tyr Val Asn Ala Lys Gly Lys Pro Ile Lys Asn Leu Ala Lys 
385                 390                 395                 400 


Lys Thr Tyr Asp Asp Thr Phe Ile Gln Ala Leu Leu Asn Leu Asn Phe 
                405                 410                 415     


Thr Lys Met Gly His Leu Ser Phe Lys Ala Leu Lys Asn Ile Ile Pro 
            420                 425                 430         


Phe Leu Glu Glu Gly Leu Ser Tyr Asp Lys Ala Cys Glu Lys Ala Gly 
        435                 440                 445             


Tyr Asn Phe Lys Gly Thr Ser Tyr Thr Glu Arg Thr Lys Tyr Leu Pro 
    450                 455                 460                 


Val Ile Pro Gln Asn Thr Asn Pro Val Val His Arg Ala Leu Ser Gln 
465                 470                 475                 480 


Thr Arg Lys Val Ile Asn Ala Ile Ile Lys Lys Tyr Gly Ser Pro Asn 
                485                 490                 495     


Ala Ile His Ile Glu Thr Ala Arg Glu Leu Ser Lys Thr Phe Gln Glu 
            500                 505                 510         


Arg Lys Glu Ile Asp Ser Arg Tyr Gln Asp Asn Ser Lys Lys Asn Glu 
        515                 520                 525             


His Ala Ile His Lys Leu Lys Glu Leu Gly Asn Ile Asn Pro Ser Gly 
    530                 535                 540                 


Ile Asn Ile Val Lys Phe Lys Leu Trp Ser Glu Gln Asp Gly Arg Cys 
545                 550                 555                 560 


Met Tyr Ser Gly Lys Tyr Ile Glu Pro His Arg Leu Phe Glu Glu Gly 
                565                 570                 575     


Tyr Thr Glu Val Asp His Ile Leu Pro Tyr Ser Arg Ser Leu Asp Asp 
            580                 585                 590         


Ser Tyr Asn Asn Lys Ile Leu Thr Leu Gly Thr Glu Asn Gln Arg Lys 
        595                 600                 605             


Gly Asn Lys Thr Pro Tyr Glu Tyr Met Gly Asn Thr Ser Ile Trp Asp 
    610                 615                 620                 


Glu Phe Glu Thr Arg Val Gln Ser Asn Lys Lys Ile Asn Phe Lys Lys 
625                 630                 635                 640 


Gln Gln Lys Leu Leu Leu Gln Asn Phe Ser Tyr Ala Arg Glu Gln Glu 
                645                 650                 655     


Phe Ile Glu Arg Asn Leu Asn Asp Thr Arg Tyr Ala Thr Ile Tyr Leu 
            660                 665                 670         


Thr Ser Leu Ile Gln Gln His Leu Ile Phe Ser Glu Ser Ser Ser Lys 
        675                 680                 685             


Lys Lys Val Arg Thr Val Ser Gly Ile Ile Thr Ser His Leu Arg Ser 
    690                 695                 700                 


Arg Trp Gly Phe Asn Lys Asp Arg Lys Glu Gly His Ile His His Ala 
705                 710                 715                 720 


Leu Asp Ala Val Ile Val Ala Val Thr Ser Asn His Met Ile Gln Arg 
                725                 730                 735     


Val Thr Lys Tyr Tyr Lys Leu Lys Glu Leu Asn Lys Asn Leu Gln Ala 
            740                 745                 750         


Lys Gln Leu Pro Phe Pro Glu Pro Trp Glu Gly Phe Arg Leu Glu Leu 
        755                 760                 765             


Glu Ala Arg Ile Ser Pro Asn Thr Gln Gln Tyr Leu Lys Gly Ile His 
    770                 775                 780                 


Phe Lys Asn Tyr Ala Asp Val Asn Leu Ser Asp Ile Lys Pro Ile Phe 
785                 790                 795                 800 


Val Ser Arg Met Pro Lys Arg Ser Ile Thr Gly Glu Leu His Gln Glu 
                805                 810                 815     


Thr Ile Arg Lys Phe Leu Gly Tyr Asn Glu Lys Gly Lys Val Leu Thr 
            820                 825                 830         


Ala Ile Lys Thr Lys Leu Glu Asp Ile Pro Phe Asp Ala Asn Gly Asp 
        835                 840                 845             


Phe Pro Met Tyr Gly Lys Glu Thr Asp Leu Tyr Thr Tyr Asn Ala Ile 
    850                 855                 860                 


Lys Glu Arg Tyr Leu Ser His Glu Lys Asp Lys Arg Lys Ser Phe Gln 
865                 870                 875                 880 


Glu Pro Leu Tyr Lys Pro Thr Lys Ser Gly Glu Ile Gly Pro Leu Ile 
                885                 890                 895     


Lys Ser Ile Lys Ile Met Asp Thr Arg Thr Ile Val Asn Pro Val Asn 
            900                 905                 910         


Gln Gly Lys Gly Val Val Tyr Asn Ser Lys Ile Ala Arg Thr Asp Val 
        915                 920                 925             


Phe Lys Lys Glu Asp Lys Tyr Tyr Leu Ile Pro Ile Tyr Thr Ile Asp 
    930                 935                 940                 


Leu Leu Lys Asn Ile Leu Pro His Lys Ala Ile Thr Ala Gly Lys Gly 
945                 950                 955                 960 


Tyr Glu Asp Trp Thr Thr Ile Asp Ser Ser Phe Thr Phe Leu Phe Ser 
                965                 970                 975     


Leu Phe Pro Asn Asp Leu Ile Gln Ile Val Pro Ser Lys Asn Lys Thr 
            980                 985                 990         


Ile Lys Ala Arg Thr Thr Val Ser  Lys Lys Glu Ile Leu  Leu Pro Ser 
        995                 1000                 1005             


Leu Thr  Gly Tyr Phe Lys Gly  Val His Ser Gly Thr  Ala Gly Ile 
    1010                 1015                 1020             


Thr Val  Glu Thr His Asp Gly  Ser Val Ile Ala Asn  Val Gly Ser 
    1025                 1030                 1035             


Lys Gln  Leu Leu Leu Phe Glu  Lys Tyr Gln Val Asp  Val Leu Gly 
    1040                 1045                 1050             


His Tyr  Thr Lys Ile Lys Glu  Glu Lys Arg Met Gly  Met Ala Ile 
    1055                 1060                 1065             


<210> 69
<211> 1078
<212> PRT
<213> Bacillus cereus


<220>
<223> Bacillus cereus BAG4X2-1

<400> 69
Met Arg Tyr Val Leu Gly Leu Asp Ile Gly Ile Ala Ser Cys Gly Trp 
1               5                   10                  15      


Ala Val Ile Asn Gln Glu Lys Glu Arg Ile Glu Asp Leu Gly Val Arg 
            20                  25                  30          


Ile Phe Asp Lys Ala Glu Asn Pro Lys Asp Gly Lys Ser Leu Ala Ala 
        35                  40                  45              


Pro Arg Arg Asp Ala Arg Ser Thr Arg Arg Thr Leu Arg Arg Lys Lys 
    50                  55                  60                  


His Arg Met Gln Arg Ile Lys Val Leu Leu Val Lys His Gly Leu Leu 
65                  70                  75                  80  


Ser Lys Thr Glu Leu Asp His Leu Tyr Glu Ser Ala Thr Glu Val Asp 
                85                  90                  95      


Val Trp Asn Leu Arg Leu Asp Ala Leu Glu Arg Lys Leu Tyr Pro Lys 
            100                 105                 110         


Glu Phe Ala Arg Ile Leu Ile His Leu Ala Lys Arg Arg Gly Phe Lys 
        115                 120                 125             


Ser Asn Arg Lys Glu Thr Thr Leu Ser Glu Asn Gly Gln Ile Leu Glu 
    130                 135                 140                 


Ser Ile Ser Glu Asn Gln Gln Ile Met Glu Lys Gln Asn Tyr Arg Thr 
145                 150                 155                 160 


Val Gly Glu Met Ile Leu Lys Asp Lys Lys Phe Glu Asn His Lys Arg 
                165                 170                 175     


Asn Lys Asn Gly Thr Tyr Val Gly Thr Val Thr Arg Gln Gln Leu Gln 
            180                 185                 190         


Asp Glu Ile Gln Met Ile Phe His Ala Gln Arg Leu Tyr Lys Asn Asp 
        195                 200                 205             


Tyr Ala Thr Glu Glu Phe Glu Ser Ser Tyr Leu Glu Ile Trp Ala Ser 
    210                 215                 220                 


Gln Arg Pro Tyr Ala Ser Lys Asp Gln Ile Glu Lys Met Ile Gly Tyr 
225                 230                 235                 240 


Cys Thr Leu Glu Pro Lys Glu Lys Arg Ala Pro Lys Ala Ser Trp Ser 
                245                 250                 255     


Phe Gln Tyr Phe Val Ala Leu Gln Thr Ile Asn Asn Leu Arg Leu Ile 
            260                 265                 270         


Ser Lys Asp Arg Ile Glu Glu Leu Ser Phe Glu Glu Lys Lys Gln Ile 
        275                 280                 285             


Met Asn Leu Ala Leu Glu Lys Ser Ile Val Lys Tyr Ile Asp Ile Arg 
    290                 295                 300                 


Lys Leu Leu Ser Val Pro Asn Glu Phe Gln Phe Asn Ser Leu Ser Tyr 
305                 310                 315                 320 


Ser Ala Asp Thr Val Asp Thr Ala Val Glu Ser Arg Lys Cys Ile Glu 
                325                 330                 335     


Leu Lys Glu Tyr His Ser Ile Asn Lys Val Tyr Lys Gln Ile Tyr Gly 
            340                 345                 350         


Glu Asn Ala Leu Asn Leu Leu Pro Lys Tyr Tyr Asp Thr Ile Ala Tyr 
        355                 360                 365             


Gly Leu Thr Ile Phe Lys Asp Asp Lys Asp Ile Leu Glu Tyr Leu Gln 
    370                 375                 380                 


Asn Lys Tyr Val Asn Ala Lys Gly Lys Pro Ile Ser Asn Phe Ala Asn 
385                 390                 395                 400 


Lys Thr Tyr Asp Asp Thr Phe Ile Gln Ala Leu Leu Asn Leu Asn Phe 
                405                 410                 415     


Thr Lys Met Gly His Leu Ser Phe Lys Ala Leu Lys Asn Ile Ile Pro 
            420                 425                 430         


Phe Leu Glu Glu Gly Leu Ser Tyr Asp Lys Ala Cys Glu Lys Ala Gly 
        435                 440                 445             


Tyr Asn Phe Lys Gly Thr Ser Tyr Thr Glu Gln Thr Lys Tyr Leu Pro 
    450                 455                 460                 


Val Ile Pro Gln Asn Thr Asn Pro Val Val His Arg Ala Leu Ser Gln 
465                 470                 475                 480 


Thr Arg Lys Val Ile Asn Ala Ile Ile Lys Lys Tyr Gly Ser Pro Asn 
                485                 490                 495     


Ala Ile His Ile Glu Thr Ala Arg Glu Leu Ser Lys Thr Phe Gln Glu 
            500                 505                 510         


Arg Lys Glu Ile Asp Ser Met Tyr Gln Asp Asn Ser Lys Lys Asn Glu 
        515                 520                 525             


His Ala Ile His Lys Leu Lys Glu Leu Gly Asn Ile Asn Pro Ser Gly 
    530                 535                 540                 


Ile Asn Ile Val Lys Phe Lys Leu Trp Asn Glu Gln Asp Gly Arg Cys 
545                 550                 555                 560 


Met Tyr Ser Gly Lys Tyr Ile Glu Pro His Arg Leu Phe Glu Glu Gly 
                565                 570                 575     


Tyr Thr Glu Val Asp His Ile Leu Pro Tyr Ser Arg Ser Leu Asp Asp 
            580                 585                 590         


Ser Tyr Asn Asn Lys Thr Leu Thr Leu Gly Thr Glu Asn Gln Arg Lys 
        595                 600                 605             


Gly Asn Lys Ile Pro Tyr Glu Tyr Met Gly Asn Thr Ser Ile Trp Asn 
    610                 615                 620                 


Asp Phe Glu Thr Arg Val Gln Ser Asn Lys Lys Ile Asn Lys Lys Lys 
625                 630                 635                 640 


Gln Gln Lys Leu Leu Leu Gln His Phe Ser Tyr Ala Arg Glu Gln Glu 
                645                 650                 655     


Phe Ile Glu Arg Asn Leu Asn Asp Thr Arg Tyr Ala Thr Ile Tyr Leu 
            660                 665                 670         


Ser Ser Leu Ile Gln Gln His Leu Ile Phe Ser Glu Ser Ser Arg Lys 
        675                 680                 685             


Lys Lys Val His Thr Val Ser Gly Ile Ile Thr Ser His Leu Arg Ser 
    690                 695                 700                 


Arg Trp Gly Phe Asn Lys Asp Arg Lys Glu Gly His Ile His His Ala 
705                 710                 715                 720 


Leu Asp Ala Val Ile Val Ala Val Thr Ser Asp His Met Ile Gln Arg 
                725                 730                 735     


Val Thr Lys Tyr Tyr Lys Leu Lys Glu Leu Asn Arg Asn Leu Gln Ala 
            740                 745                 750         


Lys Arg Met Pro Phe Pro Glu Pro Trp Glu Gly Phe Arg Leu Glu Leu 
        755                 760                 765             


Glu Ala Arg Ile Ser Pro Asn Thr Gln Gln Tyr Leu Lys Gly Leu Arg 
    770                 775                 780                 


Phe Lys Asn Tyr Ala Asp Val Asn Leu Ser Glu Ile Lys Ser Ile Phe 
785                 790                 795                 800 


Val Ser Arg Met Pro Lys His Ser Ile Thr Gly Glu Leu His Gln Glu 
                805                 810                 815     


Thr Ile Arg Lys Phe Ile Gly Tyr Asn Glu Lys Gly Lys Val Leu Thr 
            820                 825                 830         


Ala Ile Lys Thr Lys Leu Glu Asp Ile Pro Phe Asp Ala Asn Gly Asp 
        835                 840                 845             


Phe Pro Met Tyr Gly Lys Glu Ser Asp Leu Tyr Thr Tyr Asn Ala Ile 
    850                 855                 860                 


Lys Glu Arg Tyr Leu Ser His Lys Lys Asp Lys Arg Lys Ser Phe Gln 
865                 870                 875                 880 


Glu Pro Leu Tyr Lys Pro Thr Lys Ser Gly Gly Ile Gly Pro Leu Ile 
                885                 890                 895     


Lys Ser Ile Lys Ile Met Asp Thr Arg Thr Ile Val Asn Pro Val Asn 
            900                 905                 910         


Gln Gly Lys Gly Val Val Tyr Asn Ser Lys Ile Ala Arg Thr Asp Val 
        915                 920                 925             


Phe Lys Lys Glu Glu Lys Tyr Tyr Leu Ile Pro Ile Tyr Thr Ile Asp 
    930                 935                 940                 


Leu Met Lys Asn Ile Leu Pro Gln Lys Ala Ile Thr Ala Gly Lys Gly 
945                 950                 955                 960 


Tyr Glu Asp Trp Thr Thr Ile Asp Pro Ser Phe Thr Phe Leu Phe Ser 
                965                 970                 975     


Leu Phe Pro Asn Asp Leu Ile Gln Ile Val Pro Ser Lys Asn Lys Thr 
            980                 985                 990         


Ile Lys Ala Arg Thr Thr Val Ser  Lys Lys Glu Val Leu  Leu Pro Ser 
        995                 1000                 1005             


Leu Thr  Gly Tyr Phe Lys Gly  Val His Ser Gly Thr  Ala Gly Ile 
    1010                 1015                 1020             


Thr Val  Glu Thr His Asp Gly  Ser Val Ile Ala Asn  Val Gly Ser 
    1025                 1030                 1035             


Lys Gln  Leu Leu Leu Ile Glu  Lys Tyr Gln Val Asp  Val Leu Gly 
    1040                 1045                 1050             


Asn Tyr  Thr Lys Ile Lys Glu  Glu Lys Arg Ile Gly  Leu Thr Thr 
    1055                 1060                 1065             


Tyr Asn  Asp Asn Lys Lys Ile  Ala Ala Cys 
    1070                 1075             


<210> 70
<211> 1069
<212> PRT
<213> Bacillus cereus


<220>
<223> Bacillus cereus Rock1-15

<400> 70
Met Asn Tyr Asp Ile Gly Leu Arg Ile Gly Ile Thr Ser Cys Gly Trp 
1               5                   10                  15      


Ser Ile Ile Asn Lys Asp Leu Glu Arg Ile Glu Asp Leu Gly Val Arg 
            20                  25                  30          


Val Phe Glu Lys Ala Glu Asn Pro Asp Gly Thr Ala Ser Ala Ala Pro 
        35                  40                  45              


Arg Arg Glu Ala Arg Lys Ser Arg Arg Lys His Arg Arg Lys Lys His 
    50                  55                  60                  


Arg Ile Glu Arg Ile Lys Arg Leu Ile Val Gln His Asp Leu Leu Ser 
65                  70                  75                  80  


Lys Lys Glu Leu Asp Ser Leu Tyr Leu Ser Pro Phe Asn Ile Asp Val 
                85                  90                  95      


Trp Asn Leu Gln Val Glu Ala Leu Glu Arg Lys Leu Asp Asn Arg Glu 
            100                 105                 110         


Phe Ala Arg Val Leu Ile His Leu Val Gln Arg Arg Gly Phe Gln Thr 
        115                 120                 125             


Ile Arg Lys Ser Val Glu Ile Gln Glu Glu Gly Lys Leu Leu Glu Asn 
    130                 135                 140                 


Val Ser Glu Asn Glu Arg Ile Met Lys Val Asn Gly Tyr Lys Thr Val 
145                 150                 155                 160 


Gly Glu Met Phe Ser Lys His Glu Lys Phe Thr His His Lys Arg Asn 
                165                 170                 175     


Lys Asp Gly Ser Tyr Thr Ser Val Val Thr Arg Ser Leu Leu Leu Lys 
            180                 185                 190         


Glu Ile Lys Thr Ile Phe Asn Ser Gln Arg Ile Leu Gly Asn Val Phe 
        195                 200                 205             


Ser Thr Gln Lys Leu Glu Ser Asp Tyr Leu Tyr Ile Trp Gly Ser Gln 
    210                 215                 220                 


Arg Pro Thr Leu Thr Tyr Glu Gln Leu Met Ser Met Val Gly Asn Cys 
225                 230                 235                 240 


Ile Tyr Glu Lys Lys Glu Lys Arg Ala Pro Lys Thr Ser Trp Ala Phe 
                245                 250                 255     


Gln Tyr Phe Ser Leu Leu Gln Lys Ile Asn Lys Leu Lys Val Ser Asp 
            260                 265                 270         


Asp Asn Thr Leu Arg Lys Leu Ser Lys Glu Glu Arg Asp Ile Val Ile 
        275                 280                 285             


Glu Leu Ala Phe Lys Lys Lys Asn Val Ser Phe Val Asp Ile Arg Lys 
    290                 295                 300                 


Ala Leu Lys Leu Asn Asp Asn Thr Lys Phe Asn His Leu Thr Tyr Ser 
305                 310                 315                 320 


His Val Val Glu Thr Lys Lys Val Glu Lys Ala Thr Phe Ile Glu Leu 
                325                 330                 335     


Lys Gly Tyr His Leu Ile Lys Lys Gln Leu Lys Asp Arg Asn Val Glu 
            340                 345                 350         


Leu Thr Gln Glu Leu Gln Pro Lys Asp Tyr Asp Ala Ile Ala Ala Ala 
        355                 360                 365             


Ser Thr Phe Phe Lys Asn Asp Ile Glu Phe Arg Asp Tyr Leu Arg Asn 
    370                 375                 380                 


Gln Tyr Leu Asp Ser Asn Gly Lys Arg Lys Ser Asn Ile Ala Asn Lys 
385                 390                 395                 400 


Val Phe Glu Asp Lys Val Ile Ala Ala Val Phe Glu Leu Asn Phe Ser 
                405                 410                 415     


Lys Val Cys His Leu Ser Phe Lys Ser Leu Tyr Lys Leu Ile Pro His 
            420                 425                 430         


Leu Glu Lys Gly Leu Asp Tyr Lys Glu Ala Ile Leu Cys Ala Gly Tyr 
        435                 440                 445             


Asn Phe Arg Asp Glu Asn Lys Arg Asp Lys Lys Leu Phe Leu Pro Val 
    450                 455                 460                 


Ile Gln Gln Glu Thr Asn Pro Val Val His Arg Ala Leu Thr Gln Ala 
465                 470                 475                 480 


Arg Lys Val Ile Asn Ala Ile Ile Arg Glu Tyr Gly Ser Pro Asn Thr 
                485                 490                 495     


Ile Arg Phe Val Val Ala Asn Asp Leu Ala Lys Thr Tyr Lys Gln Arg 
            500                 505                 510         


Lys Glu Leu Glu Ser Thr Leu Lys Lys Asn Arg Ala Glu Asn Glu Lys 
        515                 520                 525             


Ile Lys Thr Lys Leu Leu Ser Met Gly Ile Ile Asn Pro Thr Gly Met 
    530                 535                 540                 


Asp Ile Val Lys Tyr Lys Leu Trp Tyr Glu Gln Ser Gly Ile Cys Leu 
545                 550                 555                 560 


Tyr Thr Gly Arg Gln Met Glu Leu Ser Ser Leu Phe Lys Pro Gly Tyr 
                565                 570                 575     


Ser Ile Val Asn His Ile Ile Pro Tyr Asn Arg Ser Phe Asp Asp Thr 
            580                 585                 590         


Tyr His Asn Arg Val Leu Thr Leu Thr Glu Thr Lys Tyr Glu Lys Gly 
        595                 600                 605             


Asn Lys Ile Pro Phe Glu Tyr Phe Gly Ala Glu Glu Thr Cys Trp Asn 
    610                 615                 620                 


Glu Tyr Glu Lys Arg Val Ser Thr Ser Lys Lys Ile His Asp Lys Lys 
625                 630                 635                 640 


Arg Glu Lys Leu Leu Ile Arg Asn Phe Asp Ile Glu Tyr Glu Asn Glu 
                645                 650                 655     


Met Ile Ser Asn Asn Val Phe Asp Thr His Tyr Ile Gly Ser Tyr Phe 
            660                 665                 670         


Glu Lys Tyr Ile Asp Glu His Leu Gln Phe Lys Lys Ser Thr Lys Lys 
        675                 680                 685             


Gln Lys Val Phe Ser Ile His Gly Asn Met Val Ala His Leu His Ser 
    690                 695                 700                 


Arg Trp Gly Phe Asn Lys Asn Ser Arg Glu Ile Tyr Leu Asn His Ala 
705                 710                 715                 720 


Val Asp Ala Ala Ile Val Ala Val Leu Thr Asp Gln Leu Ile Arg Asn 
                725                 730                 735     


Ile Ala Asp Tyr Tyr Arg Arg Asp Asn Ile Leu Glu Gln Lys Gly Ser 
            740                 745                 750         


Leu Lys Phe Pro Glu Pro Trp Lys Ser Phe Ser Ile Glu Leu Glu Ala 
        755                 760                 765             


Arg Ile Ser Pro Gln Val Arg Asp Leu Ile Lys Lys Leu Asn Leu Asp 
    770                 775                 780                 


Ser Tyr Leu Asp Val Asp Ile Leu His Ile Lys Pro Val Phe Ile Ser 
785                 790                 795                 800 


Lys Lys Pro Arg Arg Lys Val Asn Gly Glu Ala His Lys Ser Thr Ile 
                805                 810                 815     


Arg Ser Leu Ile Gly Ile Asn Glu Ile Gly Lys Thr Val Thr Cys Ile 
            820                 825                 830         


Lys Thr Arg Leu Glu Asp Ile Pro Phe Asp Glu Asn Gly Asp Phe Pro 
        835                 840                 845             


Met Tyr Gly Lys Asp Thr Asp Lys Tyr Thr Tyr Thr Ala Ile Lys Glu 
    850                 855                 860                 


Arg Tyr Leu Glu Phe Asn Lys Asp Lys Glu Lys Ala Phe Ser Thr Pro 
865                 870                 875                 880 


Leu Tyr Lys Leu Lys Arg Asn Gly Glu Pro Gly Asn Gln Ile Lys Ser 
                885                 890                 895     


Val Lys Ile Ile Asp Thr Arg Asn Ile Val Asn Lys Val Asn Gln Gly 
            900                 905                 910         


Lys Gly Ile Ala Tyr Asn Ser Asn Ile Ile Arg Val Asp Val Phe Ser 
        915                 920                 925             


Arg Asp Gln Lys Tyr Tyr Val Val Pro Ile Tyr Leu Arg Asp Phe Ile 
    930                 935                 940                 


Lys Gly Ser Leu Pro Asn Lys Ile Ile Thr Ala Ala Lys Gly Phe Met 
945                 950                 955                 960 


Gln Trp Pro Glu Thr Asp Asn Ser Tyr Thr Phe Leu Phe Ser Ile Phe 
                965                 970                 975     


Pro Asn Asp Leu Ile Lys Val Val Pro Lys Glu Gly Lys Phe Ile Lys 
            980                 985                 990         


Ala Lys Asn Glu Asn Lys Glu Asn  Ile Asn Leu Thr Glu  Ile Leu Gly 
        995                 1000                 1005             


Tyr Phe  Lys Gly Leu Asp Ser  Ser Thr Gly Ala Phe  Thr Leu Glu 
    1010                 1015                 1020             


Ser His  Asp Gly Ser Leu Leu  Ala Arg Gly Ile Gly  Thr Lys Asn 
    1025                 1030                 1035             


Leu Leu  Leu Ile Glu Lys Tyr  Gln Val Asp Val Leu  Gly Arg Tyr 
    1040                 1045                 1050             


Asn Lys  Val Gly Asn Glu Glu  Arg Gln Asp Ile Lys  Ile Gln Gln 
    1055                 1060                 1065             


Asn 
    


<210> 71
<211> 1088
<212> PRT
<213> Bacillus smithii


<220>
<223> Bacillus smithii 7_3_47FAA

<400> 71
Met Asn Tyr Lys Met Gly Leu Asp Ile Gly Ile Ala Ser Val Gly Trp 
1               5                   10                  15      


Ala Val Ile Asn Leu Asp Leu Lys Arg Ile Glu Asp Leu Gly Val Arg 
            20                  25                  30          


Ile Phe Asp Lys Ala Glu His Pro Gln Asn Gly Glu Ser Leu Ala Leu 
        35                  40                  45              


Pro Arg Arg Ile Ala Arg Ser Ala Arg Arg Arg Leu Arg Arg Arg Lys 
    50                  55                  60                  


His Arg Leu Glu Arg Ile Arg Arg Leu Leu Val Ser Glu Asn Val Leu 
65                  70                  75                  80  


Thr Lys Glu Glu Met Asn Leu Leu Phe Lys Gln Lys Lys Gln Ile Asp 
                85                  90                  95      


Val Trp Gln Leu Arg Val Asp Ala Leu Glu Arg Lys Leu Asn Asn Asp 
            100                 105                 110         


Glu Leu Ala Arg Val Leu Leu His Leu Ala Lys Arg Arg Gly Phe Lys 
        115                 120                 125             


Ser Asn Arg Lys Ser Glu Arg Asn Ser Lys Glu Ser Ser Glu Phe Leu 
    130                 135                 140                 


Lys Asn Ile Glu Glu Asn Gln Ser Ile Leu Ala Gln Tyr Arg Ser Val 
145                 150                 155                 160 


Gly Glu Met Ile Val Lys Asp Ser Lys Phe Ala Tyr His Lys Arg Asn 
                165                 170                 175     


Lys Leu Asp Ser Tyr Ser Asn Met Ile Ala Arg Asp Asp Leu Glu Arg 
            180                 185                 190         


Glu Ile Lys Leu Ile Phe Glu Lys Gln Arg Glu Phe Asn Asn Pro Val 
        195                 200                 205             


Cys Thr Glu Arg Leu Glu Glu Lys Tyr Leu Asn Ile Trp Ser Ser Gln 
    210                 215                 220                 


Arg Pro Phe Ala Ser Lys Glu Asp Ile Glu Lys Lys Val Gly Phe Cys 
225                 230                 235                 240 


Thr Phe Glu Pro Lys Glu Lys Arg Ala Pro Lys Ala Thr Tyr Thr Phe 
                245                 250                 255     


Gln Ser Phe Ile Val Trp Glu His Ile Asn Lys Leu Arg Leu Val Ser 
            260                 265                 270         


Pro Asp Glu Thr Arg Ala Leu Thr Glu Ile Glu Arg Asn Leu Leu Tyr 
        275                 280                 285             


Lys Gln Ala Phe Ser Lys Asn Lys Met Thr Tyr Tyr Asp Ile Arg Lys 
    290                 295                 300                 


Leu Leu Asn Leu Ser Asp Asp Ile His Phe Lys Gly Leu Leu Tyr Asp 
305                 310                 315                 320 


Pro Lys Ser Ser Leu Lys Gln Ile Glu Asn Ile Arg Phe Leu Glu Leu 
                325                 330                 335     


Asp Ser Tyr His Lys Ile Arg Lys Cys Ile Glu Asn Val Tyr Gly Lys 
            340                 345                 350         


Asp Gly Ile Arg Met Phe Asn Glu Thr Asp Ile Asp Thr Phe Gly Tyr 
        355                 360                 365             


Ala Leu Thr Ile Phe Lys Asp Asp Glu Asp Ile Val Ala Tyr Leu Gln 
    370                 375                 380                 


Asn Glu Tyr Ile Thr Lys Asn Gly Lys Arg Val Ser Asn Leu Ala Asn 
385                 390                 395                 400 


Lys Val Tyr Asp Lys Ser Leu Ile Asp Glu Leu Leu Asn Leu Ser Phe 
                405                 410                 415     


Ser Lys Phe Ala His Leu Ser Met Lys Ala Ile Arg Asn Ile Leu Pro 
            420                 425                 430         


Tyr Met Glu Gln Gly Glu Ile Tyr Ser Lys Ala Cys Glu Leu Ala Gly 
        435                 440                 445             


Tyr Asn Phe Thr Gly Pro Lys Lys Lys Glu Lys Ala Leu Leu Leu Pro 
    450                 455                 460                 


Val Ile Pro Asn Ile Ala Asn Pro Val Val Met Arg Ala Leu Thr Gln 
465                 470                 475                 480 


Ser Arg Lys Val Val Asn Ala Ile Ile Lys Lys Tyr Gly Ser Pro Val 
                485                 490                 495     


Ser Ile His Ile Glu Leu Ala Arg Asp Leu Ser His Ser Phe Asp Glu 
            500                 505                 510         


Arg Lys Lys Ile Gln Lys Asp Gln Thr Glu Asn Arg Lys Lys Asn Glu 
        515                 520                 525             


Thr Ala Ile Lys Gln Leu Ile Glu Tyr Glu Leu Thr Lys Asn Pro Thr 
    530                 535                 540                 


Gly Leu Asp Ile Val Lys Phe Lys Leu Trp Ser Glu Gln Gln Gly Arg 
545                 550                 555                 560 


Cys Met Tyr Ser Leu Lys Pro Ile Glu Leu Glu Arg Leu Leu Glu Pro 
                565                 570                 575     


Gly Tyr Val Glu Val Asp His Ile Leu Pro Tyr Ser Arg Ser Leu Asp 
            580                 585                 590         


Asp Ser Tyr Ala Asn Lys Val Leu Val Leu Thr Lys Glu Asn Arg Glu 
        595                 600                 605             


Lys Gly Asn His Thr Pro Val Glu Tyr Leu Gly Leu Gly Ser Glu Arg 
    610                 615                 620                 


Trp Lys Lys Phe Glu Lys Phe Val Leu Ala Asn Lys Gln Phe Ser Lys 
625                 630                 635                 640 


Lys Lys Lys Gln Asn Leu Leu Arg Leu Arg Tyr Glu Glu Thr Glu Glu 
                645                 650                 655     


Lys Glu Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr Ile Ser Lys 
            660                 665                 670         


Phe Phe Ala Asn Phe Ile Lys Glu His Leu Lys Phe Ala Asp Gly Asp 
        675                 680                 685             


Gly Gly Gln Lys Val Tyr Thr Ile Asn Gly Lys Ile Thr Ala His Leu 
    690                 695                 700                 


Arg Ser Arg Trp Asp Phe Asn Lys Asn Arg Glu Glu Ser Asp Leu His 
705                 710                 715                 720 


His Ala Val Asp Ala Val Ile Val Ala Cys Ala Thr Gln Gly Met Ile 
                725                 730                 735     


Lys Lys Ile Thr Glu Phe Tyr Lys Ala Arg Glu Gln Asn Lys Glu Ser 
            740                 745                 750         


Ala Lys Lys Lys Glu Pro Ile Phe Pro Gln Pro Trp Pro His Phe Ala 
        755                 760                 765             


Asp Glu Leu Lys Ala Arg Leu Ser Lys Phe Pro Gln Glu Ser Ile Glu 
    770                 775                 780                 


Ala Phe Ala Leu Gly Asn Tyr Asp Arg Lys Lys Leu Glu Ser Leu Arg 
785                 790                 795                 800 


Pro Val Phe Val Ser Arg Met Pro Lys Arg Ser Val Thr Gly Ala Ala 
                805                 810                 815     


His Gln Glu Thr Leu Arg Arg Cys Val Gly Ile Asp Glu Gln Ser Gly 
            820                 825                 830         


Lys Ile Gln Thr Ala Val Lys Thr Lys Leu Ser Asp Ile Lys Leu Asp 
        835                 840                 845             


Lys Asp Gly His Phe Pro Met Tyr Gln Lys Glu Ser Asp Pro Arg Thr 
    850                 855                 860                 


Tyr Glu Ala Ile Arg Gln Arg Leu Leu Glu His Asn Asn Asp Pro Lys 
865                 870                 875                 880 


Lys Ala Phe Gln Glu Pro Leu Tyr Lys Pro Lys Lys Asn Gly Glu Pro 
                885                 890                 895     


Gly Pro Val Ile Arg Thr Val Lys Ile Ile Asp Thr Lys Asn Lys Val 
            900                 905                 910         


Val His Leu Asp Gly Ser Lys Thr Val Ala Tyr Asn Ser Asn Ile Val 
        915                 920                 925             


Arg Thr Asp Val Phe Glu Lys Asp Gly Lys Tyr Tyr Cys Val Pro Val 
    930                 935                 940                 


Tyr Thr Met Asp Ile Met Lys Gly Thr Leu Pro Asn Lys Ala Ile Glu 
945                 950                 955                 960 


Ala Asn Lys Pro Tyr Ser Glu Trp Lys Glu Met Thr Glu Glu Tyr Thr 
                965                 970                 975     


Phe Gln Phe Ser Leu Phe Pro Asn Asp Leu Val Arg Ile Val Leu Pro 
            980                 985                 990         


Arg Glu Lys Thr Ile Lys Thr Ser  Thr Asn Glu Glu Ile  Ile Ile Lys 
        995                 1000                 1005             


Asp Ile  Phe Ala Tyr Tyr Lys  Thr Ile Asp Ser Ala  Thr Gly Gly 
    1010                 1015                 1020             


Leu Glu  Leu Ile Ser His Asp  Arg Asn Phe Ser Leu  Arg Gly Val 
    1025                 1030                 1035             


Gly Ser  Lys Thr Leu Lys Arg  Phe Glu Lys Tyr Gln  Val Asp Val 
    1040                 1045                 1050             


Leu Gly  Asn Ile His Lys Val  Lys Gly Glu Lys Arg  Val Gly Leu 
    1055                 1060                 1065             


Ala Ala  Pro Thr Asn Gln Lys  Lys Gly Lys Thr Val  Asp Ser Leu 
    1070                 1075                 1080             


Gln Ser  Val Ser Asp 
    1085             


<210> 72
<211> 1069
<212> PRT
<213> Bacillus thuringiensis

<400> 72
Met Asn Tyr Asp Ile Gly Leu Arg Ile Gly Ile Thr Ser Cys Gly Trp 
1               5                   10                  15      


Ser Ile Ile Asn Lys Asp Leu Glu Arg Ile Glu Asp Leu Gly Val Arg 
            20                  25                  30          


Val Phe Glu Lys Ala Glu Asn Pro Asp Gly Thr Ala Ser Ala Ala Pro 
        35                  40                  45              


Arg Arg Glu Ala Arg Lys Ser Arg Arg Lys His Arg Arg Lys Lys His 
    50                  55                  60                  


Arg Ile Glu Arg Ile Lys Arg Leu Ile Val Gln His Asp Leu Leu Ser 
65                  70                  75                  80  


Lys Lys Glu Leu Asp Ser Leu Tyr Leu Ser Pro Phe Asn Ile Asp Val 
                85                  90                  95      


Trp Asn Leu Arg Val Glu Ala Leu Glu Arg Lys Leu Asp Asn Arg Glu 
            100                 105                 110         


Phe Ala Arg Val Leu Ile His Leu Val Gln Arg Arg Gly Phe Gln Thr 
        115                 120                 125             


Ile Arg Lys Ser Val Glu Ile Gln Glu Glu Gly Lys Leu Leu Glu Asn 
    130                 135                 140                 


Val Ser Glu Asn Glu Arg Ile Met Lys Val Asn Gly Tyr Lys Thr Val 
145                 150                 155                 160 


Gly Glu Met Phe Ser Lys His Glu Lys Phe Thr His His Lys Arg Asn 
                165                 170                 175     


Lys Asp Gly Ser Tyr Thr Ser Val Val Thr Arg Ser Leu Leu Leu Lys 
            180                 185                 190         


Glu Ile Lys Thr Ile Phe Asn Ser Gln Arg Ile Leu Gly Asn Val Phe 
        195                 200                 205             


Ser Thr Gln Lys Leu Glu Ser Asp Tyr Leu Tyr Ile Trp Gly Ser Gln 
    210                 215                 220                 


Arg Pro Thr Leu Thr Tyr Glu Gln Leu Met Ser Met Val Gly Asn Cys 
225                 230                 235                 240 


Ile Tyr Glu Lys Lys Glu Lys Arg Ala Pro Lys Thr Ser Trp Ala Phe 
                245                 250                 255     


Gln Tyr Phe Ser Leu Leu Gln Lys Ile Asn Lys Leu Lys Val Ser Asp 
            260                 265                 270         


Asp Asn Thr Leu Arg Lys Leu Ser Lys Glu Glu Arg Asp Ile Val Ile 
        275                 280                 285             


Glu Leu Ala Phe Lys Lys Lys Asn Val Ser Phe Val Asp Ile Arg Lys 
    290                 295                 300                 


Ala Leu Lys Leu Asn Asp Asn Thr Lys Phe Asn His Leu Thr Tyr Ser 
305                 310                 315                 320 


His Val Val Glu Thr Lys Lys Val Glu Lys Ala Thr Phe Ile Glu Leu 
                325                 330                 335     


Lys Gly Tyr His Leu Ile Lys Lys Gln Leu Lys Asp Arg Asn Val Glu 
            340                 345                 350         


Leu Thr Gln Glu Leu Gln Pro Lys Asp Tyr Asp Ala Ile Ala Ala Ala 
        355                 360                 365             


Ser Thr Phe Phe Lys Asn Asp Ile Glu Phe Arg Asp Tyr Leu Arg Asn 
    370                 375                 380                 


Gln Tyr Leu Asp Ser Asn Gly Lys Arg Lys Ser Asn Ile Ala Asn Lys 
385                 390                 395                 400 


Val Phe Glu Asp Lys Val Ile Ala Ala Val Phe Glu Leu Asn Phe Ser 
                405                 410                 415     


Lys Val Cys His Leu Ser Phe Lys Ser Leu Tyr Lys Leu Ile Pro His 
            420                 425                 430         


Leu Glu Lys Gly Leu Asp Tyr Lys Glu Ala Ile Leu Cys Ala Gly Tyr 
        435                 440                 445             


Asn Phe Arg Asp Glu Asn Lys Arg Asp Lys Lys Leu Phe Leu Pro Val 
    450                 455                 460                 


Ile Gln Gln Glu Thr Asn Pro Val Val His Arg Ala Leu Thr Gln Ala 
465                 470                 475                 480 


Arg Lys Val Ile Asn Ala Ile Ile Arg Glu Tyr Gly Ser Pro Asn Thr 
                485                 490                 495     


Ile Arg Phe Val Val Ala Asn Asp Leu Ala Lys Thr Tyr Lys Gln Arg 
            500                 505                 510         


Lys Glu Leu Glu Ser Thr Leu Lys Lys Asn Arg Ala Glu Asn Glu Lys 
        515                 520                 525             


Ile Lys Thr Lys Leu Leu Ser Met Gly Ile Ile Asn Pro Thr Gly Met 
    530                 535                 540                 


Asp Ile Val Lys Tyr Lys Leu Trp Tyr Glu Gln Ser Gly Ile Cys Leu 
545                 550                 555                 560 


Tyr Thr Gly Arg Gln Met Glu Leu Ser Ser Leu Phe Lys Pro Gly Tyr 
                565                 570                 575     


Ser Ile Val Asn His Ile Ile Pro Tyr Asn Arg Ser Phe Asp Asp Thr 
            580                 585                 590         


Tyr His Asn Arg Val Leu Thr Leu Thr Glu Thr Lys Tyr Glu Lys Gly 
        595                 600                 605             


Asn Lys Ile Pro Phe Glu Tyr Phe Gly Ala Glu Glu Thr Cys Trp Asn 
    610                 615                 620                 


Glu Tyr Glu Lys Arg Val Ser Thr Ser Lys Lys Ile His Asp Lys Lys 
625                 630                 635                 640 


Arg Glu Lys Leu Leu Ile Arg Asn Phe Asp Ile Glu Tyr Glu Asn Glu 
                645                 650                 655     


Met Ile Ser Asn Asn Val Phe Asp Thr His Tyr Ile Gly Ser Tyr Phe 
            660                 665                 670         


Glu Lys Tyr Ile Asp Glu His Leu Gln Phe Lys Lys Ser Thr Lys Lys 
        675                 680                 685             


Gln Lys Val Phe Ser Ile His Gly Asn Met Val Ala His Leu His Ser 
    690                 695                 700                 


Arg Trp Gly Phe Asn Lys Asn Ser Arg Glu Ile Tyr Leu Asn His Ala 
705                 710                 715                 720 


Val Asp Ala Ala Ile Val Ala Val Leu Thr Asp Gln Leu Ile Arg Asn 
                725                 730                 735     


Ile Ala Asp Tyr Tyr Arg Arg Asp Asn Ile Leu Glu Gln Lys Gly Ser 
            740                 745                 750         


Leu Lys Phe Pro Glu Pro Trp Lys Ser Phe Ser Ile Glu Leu Glu Ala 
        755                 760                 765             


Arg Ile Ser Pro Gln Val Arg Asp Leu Ile Lys Lys Leu Asn Leu Asp 
    770                 775                 780                 


Ser Tyr Leu Asp Val Asp Ile Leu His Ile Lys Pro Val Phe Ile Ser 
785                 790                 795                 800 


Lys Lys Pro Arg Arg Lys Val Asn Gly Glu Ala His Lys Ser Thr Ile 
                805                 810                 815     


Arg Ser Leu Ile Gly Ile Asn Glu Ile Gly Lys Thr Val Thr Cys Ile 
            820                 825                 830         


Lys Thr Arg Leu Glu Asp Ile Pro Phe Asp Glu Asn Gly Asp Phe Pro 
        835                 840                 845             


Met Tyr Gly Lys Asp Thr Asp Lys Tyr Thr Tyr Thr Ala Ile Lys Glu 
    850                 855                 860                 


Arg Tyr Leu Glu Phe Asn Lys Asp Lys Glu Lys Ala Phe Ser Thr Pro 
865                 870                 875                 880 


Leu Tyr Lys Leu Lys Arg Asn Gly Glu Pro Gly Asn Gln Ile Lys Ser 
                885                 890                 895     


Val Lys Ile Ile Asp Thr Arg Asn Ile Val Asn Lys Val Asn Gln Gly 
            900                 905                 910         


Lys Gly Ile Ala Tyr Asn Ser Asn Ile Ile Arg Val Asp Val Phe Ser 
        915                 920                 925             


Arg Asp Gln Lys Tyr Tyr Val Val Pro Ile Tyr Leu Arg Asp Phe Ile 
    930                 935                 940                 


Lys Gly Ser Leu Pro Asn Lys Ile Ile Thr Ala Ala Lys Gly Phe Met 
945                 950                 955                 960 


Gln Trp Pro Glu Thr Asp Asn Ser Tyr Thr Phe Leu Phe Ser Ile Phe 
                965                 970                 975     


Pro Asn Asp Leu Ile Lys Val Val Pro Lys Glu Gly Lys Phe Ile Lys 
            980                 985                 990         


Ala Lys Asn Glu Asn Lys Glu Asn  Ile Asn Leu Thr Glu  Ile Leu Gly 
        995                 1000                 1005             


Tyr Phe  Lys Gly Leu Asp Ser  Ser Thr Gly Ala Phe  Thr Leu Glu 
    1010                 1015                 1020             


Ser His  Asp Gly Ser Leu Leu  Ala Arg Gly Ile Gly  Thr Lys Asn 
    1025                 1030                 1035             


Leu Leu  Leu Ile Glu Lys Tyr  Gln Val Asp Val Leu  Gly Arg Tyr 
    1040                 1045                 1050             


Asn Lys  Val Gly Asn Glu Glu  Arg Gln Asp Ile Lys  Ile Gln Gln 
    1055                 1060                 1065             


Asn 
    


<210> 73
<211> 1509
<212> PRT
<213> Bacteroides coprophilus


<220>
<223> Bacteroides coprophilus DSM 18228

<400> 73
Met Lys Lys Thr Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Val Ile Asn Ser Asn Ile Asp Ser Glu Gly Lys Glu Lys Leu Val 
            20                  25                  30          


Gly Ile Ser Ser Cys Gly Ser Arg Ile Ile Pro Met Asp Ala Thr Thr 
        35                  40                  45              


Leu Gly Asp Phe Gly Lys Gly Asn Thr Lys Ser Pro Val Ala Glu Arg 
    50                  55                  60                  


Thr Arg Leu Arg Gly Ile Arg Arg Leu Leu Glu Arg Ser Leu Leu Arg 
65                  70                  75                  80  


Arg Glu Arg Leu His Arg Val Leu Ser Val Met Gly Phe Leu Pro Glu 
                85                  90                  95      


His Tyr Ala Ser Gln Leu Asp Arg Tyr Gly Lys Phe Leu Pro Glu Thr 
            100                 105                 110         


Glu Pro Lys Leu Ala Trp Tyr Lys Asp Asp Ser Gly Arg Tyr Gln Phe 
        115                 120                 125             


Leu Phe Gln Lys Ser Phe His Glu Met Leu Glu Asp Phe Arg Gln His 
    130                 135                 140                 


Gln Pro Glu Leu Val Ala Gly Glu Lys Lys Ile Pro Tyr Asp Trp Thr 
145                 150                 155                 160 


Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Ser Gln Glu Ile Thr Lys Glu 
                165                 170                 175     


Glu Leu Ala Trp Ile Leu Leu Asn Phe Asn Gln Lys Arg Gly Tyr Tyr 
            180                 185                 190         


Gln Leu Arg Gly Glu Glu Glu Gln Glu Glu Asn Asn Lys Ser Val Glu 
        195                 200                 205             


Tyr His Ala Leu Lys Val Val Ser Val Glu Asp Ser Gly Glu Arg Lys 
    210                 215                 220                 


Gly Lys Asp Ile Trp Tyr Asn Val Thr Leu Glu Asn Gly Trp Val Tyr 
225                 230                 235                 240 


Arg Arg Ala Ser Asn Ile Pro Leu Asp Trp Thr Gly Lys Val Lys Glu 
                245                 250                 255     


Phe Val Val Thr Thr Glu Leu Asp Asp Ala Gly Asn Pro Lys Lys Asp 
            260                 265                 270         


Lys Glu Gly Asn Val Lys Arg Ser Phe Arg Ala Pro Lys Glu Asp Asp 
        275                 280                 285             


Trp Gly Leu Leu Lys Thr Arg Thr Gln Ala Gln Ile Asp Glu Ser Gly 
    290                 295                 300                 


Lys Thr Val Gly Thr Tyr Ile Tyr Glu Ser Leu Leu Cys Met Pro Asn 
305                 310                 315                 320 


Gln Lys Ile Arg Gly Lys Leu Val Arg Thr Ile Glu Arg Lys Tyr Tyr 
                325                 330                 335     


Lys Asp Glu Leu Arg Gln Ile Leu Val Lys Gln Ser Glu Phe His Ala 
            340                 345                 350         


Ala Leu Gln Asp His Asn Leu Leu Leu Ser Cys Ile Glu Glu Leu Tyr 
        355                 360                 365             


Pro Asn Asn Glu Ala His Arg Arg Leu Leu Ser Ala Ser Ser Phe Ile 
    370                 375                 380                 


Tyr Phe Leu Ile Glu Asp Ile Leu Phe Tyr Gln Arg Pro Leu Lys Ser 
385                 390                 395                 400 


Gln Lys Gly Leu Ile Asp Asn Cys Pro Tyr Glu Ser His Ile Tyr Lys 
                405                 410                 415     


Asp Lys Lys Asp Gly Ser Leu His His Val Pro Leu Lys Cys Val Ser 
            420                 425                 430         


Lys Ser His Pro Leu Phe Gln Glu Phe Arg Leu Trp Gln Phe Leu Ser 
        435                 440                 445             


Asn Leu Arg Ile Tyr Gln Arg Glu Arg Met Met Asp Gly Ser Leu Lys 
    450                 455                 460                 


Leu Asp Val Asp Val Thr Arg Glu Phe Leu Pro Ser Glu Glu Asp Tyr 
465                 470                 475                 480 


Val Lys Leu Phe Asp Trp Leu Asn Glu Arg Lys Glu Ile Ser Gln Lys 
                485                 490                 495     


Phe Leu Leu Ala Tyr Lys Pro Phe Gly Leu Lys Lys Asn Glu Gln Ala 
            500                 505                 510         


Asn Tyr Arg Trp Asn Tyr Val Glu Asp Lys Ser Tyr Pro Cys Asn Glu 
        515                 520                 525             


Thr Arg Ala Glu Ile Lys Ser Arg Leu Ser Lys Ala Gly Val Pro Glu 
    530                 535                 540                 


Glu Phe Leu Thr Glu Glu Lys Glu Glu Ala Leu Trp His Ile Leu Tyr 
545                 550                 555                 560 


Ser Ile Ser Asp Lys Lys Glu Leu Thr Lys Ala Leu Gly Thr Phe Ala 
                565                 570                 575     


Ala Lys Asn Cys Leu Asn Glu Ser Phe Val Glu Val Phe Ala Lys Ile 
            580                 585                 590         


Pro Pro Phe Glu Ser Asn Tyr Ala Ala Tyr Ser Leu Lys Ala Ile Arg 
        595                 600                 605             


Lys Leu Leu Ala Leu Met Arg Met Gly Lys Tyr Trp Asn Glu Gln Ala 
    610                 615                 620                 


Ile Asp Arg Gln Thr Arg Asp Arg Ile Glu Lys Ile Leu Thr Gly Glu 
625                 630                 635                 640 


Tyr Asp Glu Thr Ile Arg Ser Arg Val Arg Glu Lys Ala Met Leu Leu 
                645                 650                 655     


Thr Asp Ile Ser Ser Phe Arg Gly Leu Pro Leu Trp Leu Ala Cys Tyr 
            660                 665                 670         


Ile Val Tyr Asp Arg His Ser Glu Ser Lys Glu Leu Val Lys Trp Glu 
        675                 680                 685             


Thr Pro Ala Asp Ile Asp His Phe Leu Ser Lys Phe Lys Gln Asn Ser 
    690                 695                 700                 


Leu Arg Asn Pro Ile Val Glu Gln Val Ile Thr Glu Ser Leu Arg Thr 
705                 710                 715                 720 


Val Arg Asp Ile Trp Lys Gln Glu Gly Lys Ile Asp Glu Ile His Val 
                725                 730                 735     


Glu Leu Gly Arg Glu Met Lys Asn Pro Ala Lys Glu Arg Ala Arg Ile 
            740                 745                 750         


Thr Ala Gln Val Gln Glu Asn Glu Asn Thr Asn Leu Arg Ile Lys Ala 
        755                 760                 765             


Leu Leu Ala Glu Phe Met Asn Pro Glu Phe Glu Ile Glu Asn Val His 
    770                 775                 780                 


Pro Tyr Ser Pro Gly Gln Gln Glu Ile Leu Arg Ile Tyr Glu Asp Gly 
785                 790                 795                 800 


Val Leu Ser Gly Ile Ala Glu Lys Asp Leu Pro Asp Asp Ile Thr Ala 
                805                 810                 815     


Ile Leu Lys Lys Phe Arg Glu Asn Asp Val Lys Lys Arg Pro Thr Thr 
            820                 825                 830         


Ser Glu Val Leu Arg Tyr Lys Leu Trp Leu Glu Gln Arg Tyr Arg Ser 
        835                 840                 845             


Pro Tyr Thr Gly Arg Val Ile Pro Leu Gly Lys Leu Phe Thr Pro Ala 
    850                 855                 860                 


Tyr Glu Ile Glu His Val Ile Pro Gln Ser Arg Tyr Phe Asp Asp Ser 
865                 870                 875                 880 


Ile Ser Asn Lys Val Ile Cys Glu Ser Ala Val Asn Lys Leu Lys Asp 
                885                 890                 895     


Asn Cys Leu Gly Tyr Glu Phe Ile Lys Lys His Ser Gly Glu Met Val 
            900                 905                 910         


Glu Leu Gly Asn Gly Glu Thr Val Pro Val Phe Ser Val Glu Glu Tyr 
        915                 920                 925             


Glu Arg Phe Val Lys Glu Ser Tyr Phe Gly Asn Ser Lys Lys Met Lys 
    930                 935                 940                 


Lys Leu Leu Leu Glu Asp Ile Pro Asp Ser Phe Ile Glu Arg Gln Leu 
945                 950                 955                 960 


Asn Asp Ser Arg Tyr Ile Ser Arg Val Val Thr Ser Leu Leu Ser Asn 
                965                 970                 975     


Leu Val Cys Glu Glu Gly Glu Gln Asp Gly Leu Ser Lys Asn Val Ile 
            980                 985                 990         


Val Cys Thr Gly Gly Ile Thr Asp  Arg Leu Lys Lys Asp  Trp Gly Val 
        995                 1000                 1005             


Gln Glu  Val Trp Asn Arg Ile  Ile Leu Pro Arg Phe  Leu Arg Leu 
    1010                 1015                 1020             


Asn Glu  Ile Thr Gly Arg Thr  Asp Phe Thr Ser Thr  Ser Val Asn 
    1025                 1030                 1035             


Gly His  Leu Leu Pro Ala Leu  Pro Leu Tyr Leu Gln  Lys Gly Phe 
    1040                 1045                 1050             


Asn Lys  Lys Arg Ile Asp His  Arg His His Ala Met  Asp Ala Ile 
    1055                 1060                 1065             


Val Ile  Ala Cys Ala Asn Arg  Asn Ile Val Asn Tyr  Leu Asn Asn 
    1070                 1075                 1080             


Ser Ser  Ala Arg Lys Asn Ser  Glu Ile Ser Arg Tyr  Asp Leu Gln 
    1085                 1090                 1095             


Arg Leu  Leu Cys Glu Lys Val  Lys Thr Asp Ala Asn  Gly Asn Tyr 
    1100                 1105                 1110             


Lys Trp  Ile Leu Arg Lys Pro  Trp Glu Thr Phe Thr  Gln Asp Val 
    1115                 1120                 1125             


Tyr Ala  Ala Leu Thr Asn Ile  Val Val Ser Phe Lys  Gln Asn Leu 
    1130                 1135                 1140             


Arg Val  Ile Asn Arg Thr Thr  Asn Tyr Tyr Gln His  Tyr Asn Glu 
    1145                 1150                 1155             


Ala Gly  Glu Lys Arg Met Ile  Pro Gln Thr Lys Gly  Asp Arg Trp 
    1160                 1165                 1170             


Ala Ile  Arg Lys Pro Met His  Lys Asp Thr Val Tyr  Gly Glu Val 
    1175                 1180                 1185             


Asn Leu  Arg Lys Glu Lys Thr  Leu Pro Leu Arg Asp  Val Val Lys 
    1190                 1195                 1200             


Asn Pro  Ser Ile Val Val Asp  Lys Ser Leu Lys Asn  Lys Leu Tyr 
    1205                 1210                 1215             


Glu Leu  Leu Lys Ser Gln Tyr  Asp Leu Lys Ala Ile  Ala Lys Tyr 
    1220                 1225                 1230             


Phe Glu  Thr His Gln Asp Val  Trp Ala Asp Val Asn  Leu Lys Lys 
    1235                 1240                 1245             


Ile Lys  Val Tyr Tyr Phe Thr  Lys Glu Thr Asn Glu  Arg Phe Phe 
    1250                 1255                 1260             


Ala Thr  Arg Lys Ser Leu Asp  Pro Ser Phe Asp Gln  Lys Lys Ile 
    1265                 1270                 1275             


Glu Glu  Glu Val Thr Asp Thr  Gly Val Gln Lys Ile  Leu Leu His 
    1280                 1285                 1290             


His Leu  Gln Gln Asn Asn Asn  Asp Pro Asp Met Ala  Phe Ser Pro 
    1295                 1300                 1305             


Asp Gly  Ile Asp Arg Met Asn  Gln Asn Met Thr Ile  Leu Asn Asp 
    1310                 1315                 1320             


Gly Lys  Trp His Gln Pro Ile  Tyr Lys Val Arg Thr  Tyr Glu Lys 
    1325                 1330                 1335             


Ala Asp  Lys Phe Ala Val Gly  Glu Ser Gly Asn Lys  Ala Lys Lys 
    1340                 1345                 1350             


Phe Val  Glu Ala Ala Lys Gly  Thr Asn Leu Phe Phe  Ala Val Tyr 
    1355                 1360                 1365             


Glu Ser  Val Gln Glu Asp Glu  Ala Ile Gly Lys Gln  Val Cys Lys 
    1370                 1375                 1380             


Arg Thr  Phe Ala Thr Ile Pro  Leu Asn Glu Val Ile  Lys Arg Lys 
    1385                 1390                 1395             


Lys Gln  Gly Leu Pro Ala Ala  Pro Glu Asp Leu Asn  Gly Asn Leu 
    1400                 1405                 1410             


Pro Lys  Phe Val Leu Ser Pro  Asn Asp Leu Val Tyr  Leu Pro Thr 
    1415                 1420                 1425             


Glu Glu  Glu Arg Asn Ser Ser  Arg Ile Ile Gln Pro  Leu Asp Arg 
    1430                 1435                 1440             


Glu Arg  Ile Tyr Lys Met Val  Ser Ser Ser Gly Ser  Gln Cys Phe 
    1445                 1450                 1455             


Phe Ile  Lys Val Phe Val Ala  Asn Ser Ile Trp Asp  Lys Asn Glu 
    1460                 1465                 1470             


Tyr Ser  Ser Leu Asn Lys Met  Glu Arg Ala Ile Thr  Asn Glu Met 
    1475                 1480                 1485             


Ile Lys  Glu Ile Cys Val Pro  Ile Lys Ile Asp Arg  Leu Gly Asn 
    1490                 1495                 1500             


Val Ser  Leu Ile Gln Ile 
    1505                 


<210> 74
<211> 1504
<212> PRT
<213> Bacteroides coprosuis


<220>
<223> Bacteroides coprosuis DSM 18011

<400> 74
Met Lys Lys Val Leu Gly Leu Asp Ile Gly Thr Asn Ser Val Gly Trp 
1               5                   10                  15      


Ala Val Val Asn Gln Asn Asp Lys Gly Glu Phe Leu Ser Ile Glu Lys 
            20                  25                  30          


Ile Gly Ser Arg Ile Ile Pro Met Ser Gln Asp Val Met Asp Lys Phe 
        35                  40                  45              


Gly Ala Gly Gln Thr Glu Ser Ser Thr Ala Gln Arg Thr Gln Tyr Arg 
    50                  55                  60                  


Gly Val Arg Arg Leu Arg Glu Arg Ser Leu Leu Arg Arg Glu Arg Leu 
65                  70                  75                  80  


His Arg Val Leu His Ile Leu His Phe Leu Pro Gln His Tyr Asp Ala 
                85                  90                  95      


Ala Ile Gly Trp Asn Lys Lys Glu Asn Lys Thr Tyr Gly Lys Phe Leu 
            100                 105                 110         


Pro Gly Val Glu Val Asn Ile Pro Trp Val Ala Thr Asp Gln Gly His 
        115                 120                 125             


Gln Phe Ile Phe Met Asp Ser Tyr Ala Glu Met Leu Lys Asp Leu Lys 
    130                 135                 140                 


Gln His Gln Pro His Leu Phe Glu Lys Ser Ser Thr Pro Val Pro Leu 
145                 150                 155                 160 


Asp Trp Thr Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Thr Gln Ala Ile 
                165                 170                 175     


Ser Lys Glu Glu Leu Ala Trp Ile Leu Leu Asn Phe Asn Gln Lys Arg 
            180                 185                 190         


Gly Tyr Tyr Gln Leu Arg Gly Glu Glu Val Glu Asp Asn Thr Lys Arg 
        195                 200                 205             


Glu Glu Phe Tyr Ala Leu Lys Val Val Lys Val Glu Leu Asp Lys Asp 
    210                 215                 220                 


Asn Thr Ser Ala Lys Thr Trp Tyr Lys Val His Leu Glu Asn Gly Phe 
225                 230                 235                 240 


Ile Tyr Pro Cys Pro Ser Asp Thr Pro Ile Asp Ser Trp Val Gly Met 
                245                 250                 255     


Val Lys Asp Phe Ile Val Thr Thr Thr Leu Glu Lys Asp Gly Ser Glu 
            260                 265                 270         


Lys Arg Thr Ala Asp Gly Glu Ile Lys Arg Ser Phe Arg Ala Pro Lys 
        275                 280                 285             


Glu Asp Asp Trp Thr Leu Leu Lys Lys Lys Thr Glu Ser Glu Leu Glu 
    290                 295                 300                 


Lys Ser Gly Lys Gln Val Gly Ala Phe Ile Tyr Asp Thr Leu Leu Ser 
305                 310                 315                 320 


Asn Pro Asp Gln Lys Ile Ile Gly Gly Leu Ile Lys Thr Ile Glu Arg 
                325                 330                 335     


Lys Tyr Tyr Lys Lys Glu Leu Glu Gln Ile Leu Glu Thr Gln Gln Lys 
            340                 345                 350         


Phe Ile Ala Glu Leu Ser Asp Lys Lys Leu Phe Gln Ala Cys Ala Glu 
        355                 360                 365             


Glu Leu Tyr Pro Leu Asn Asp Ser His Arg Glu Asn Leu Leu Glu Arg 
    370                 375                 380                 


Asp Phe Lys His Leu Phe Val Gln Asp Ile Ile Phe Tyr His Arg Pro 
385                 390                 395                 400 


Leu Lys Thr Lys Lys Ser Leu Ile Ser Asn Cys Thr Tyr Glu Tyr Arg 
                405                 410                 415     


Thr Phe Tyr Lys Asn Gly Glu Lys Gln Ile Ser Pro Ile Lys Cys Ile 
            420                 425                 430         


Ala Lys Ser Asn Pro Leu Phe Gln Glu Phe Arg Val Trp Gln Phe Val 
        435                 440                 445             


Gln Asn Leu Arg Ile Leu Gln Arg Gln Arg Ser Glu Gly Asp Ser Ile 
    450                 455                 460                 


Lys Tyr Asn Val Asp Val Thr Ala Glu Phe Leu Lys Asp Glu Asn Asp 
465                 470                 475                 480 


Ile Ala Asn Leu Phe Thr Trp Leu Asn Glu Arg Lys Val Ile Lys Gln 
                485                 490                 495     


Asp Gln Leu Leu Lys Ser Tyr Phe Lys Leu Lys Val Asn Lys Glu Thr 
            500                 505                 510         


Lys Glu Leu Asp Tyr Arg Trp Asn Tyr Val Asp Asp Lys Asn Lys Glu 
        515                 520                 525             


Tyr Pro Cys Asn Ala Thr Arg Thr His Ile Leu Ser Phe Leu Glu Lys 
    530                 535                 540                 


Cys Lys Glu Glu Lys Arg Ile Glu Asp Asp Arg Phe Val Tyr Ser Leu 
545                 550                 555                 560 


Trp His Leu Leu Tyr Ser Val Val Glu Pro Ile Glu Leu Arg Gly Ala 
                565                 570                 575     


Leu Ala Lys Phe Ala Glu Arg Glu His Leu His Pro Ser Phe Val Asp 
            580                 585                 590         


Val Phe Ala Gln Phe Pro Pro Leu Glu Lys Glu Tyr Gly Ser Tyr Ser 
        595                 600                 605             


Glu Lys Ala Ile Lys Arg Leu Leu Pro Leu Met Arg Met Gly Asp Tyr 
    610                 615                 620                 


Trp His Glu Asp Lys Ile Asp Val Lys Thr Lys Gln Arg Ile Gln Arg 
625                 630                 635                 640 


Ile Ile Asp Gly Glu Ala Asp Asp Asp Ile Thr His Arg Ser Arg Glu 
                645                 650                 655     


Lys Val Glu Asn Leu Arg Ser Ile Thr Asp Phe Lys Gly Leu Pro Leu 
            660                 665                 670         


Trp Lys Ala Gly Tyr Val Val Tyr Asn Arg His Ser Glu Ser Gly Glu 
        675                 680                 685             


Leu Thr Lys Trp Lys Thr Pro His Glu Leu Ser Asn Tyr Ile Gln Asn 
    690                 695                 700                 


Glu Phe Lys Gln Tyr Ser Leu Arg Asn Pro Ile Val Glu Gln Ile Val 
705                 710                 715                 720 


Leu Glu Thr Leu Arg Val Val His Asp Leu Trp Val Lys His Gly Asp 
                725                 730                 735     


Phe Ser Glu Ile His Leu Glu Leu Gly Arg Asp Ile Lys Asn Ser Ser 
            740                 745                 750         


Asp Lys Arg Lys Arg Met Ala Glu Arg Gln Gln Glu Asn Glu Asn Ser 
        755                 760                 765             


Arg Gln Arg Val Leu Glu Met Leu Ile Asp Leu Lys Lys Glu Ala Ala 
    770                 775                 780                 


Phe Ala Asp Leu Asn Pro Tyr Ser Pro Ser Gln Gln Glu Lys Leu Arg 
785                 790                 795                 800 


Ile Val Glu Asp Gly Val Leu Arg Ser Asn Ile Glu Ile Pro Lys Asp 
                805                 810                 815     


Ile Glu Lys Ile Thr Lys Ser Ala Lys Pro Thr Ser Arg Glu Leu Thr 
            820                 825                 830         


Lys Tyr Arg Leu Trp Leu Asp Gln Lys Tyr Arg Ser Pro Tyr Thr Gly 
        835                 840                 845             


Gln Pro Ile Ser Leu Ala Gln Leu Phe Thr Ser Lys Tyr Glu Ile Glu 
    850                 855                 860                 


His Val Ile Pro Gln Ala Lys Tyr Phe Asp Asp Ser Phe Thr Asn Lys 
865                 870                 875                 880 


Val Ile Cys Glu Ser Glu Val Asn Lys Glu Lys Gly Ser Met Leu Ala 
                885                 890                 895     


His Glu Phe Ile Leu Lys Asn Gly Gly Ser Thr Val Asn Val Gly Gly 
            900                 905                 910         


Arg Gln Val Gln Val Leu Lys Asn Asp Ala Tyr Val Glu Leu Ile Asn 
        915                 920                 925             


Arg Leu Tyr Gly Lys Asn Asn Pro Val Lys Ala Lys Lys Leu Leu Ala 
    930                 935                 940                 


Glu Asp Ile Asp Glu Val Val Gly Asp Phe Ser Glu Arg Gln Leu Asn 
945                 950                 955                 960 


Asp Thr Arg Tyr Ile Ser Arg Val Val Gln Lys Leu Leu Ser Asn Ile 
                965                 970                 975     


Val Arg Glu Glu Asp Glu Gln Glu Ser Thr Ser Lys His Val Ile Gly 
            980                 985                 990         


Cys Ser Gly Gln Val Thr Thr Ala  Leu Lys Lys Asp Trp  Gly Leu Asn 
        995                 1000                 1005             


Asp Ile  Trp Asn Lys Ile Ile  Gln Pro Arg Phe Glu  Arg Leu Asn 
    1010                 1015                 1020             


Glu Met  Thr Ala Thr Glu Asp  Tyr Gly Val Trp Gln  Ser Pro Asn 
    1025                 1030                 1035             


His Phe  Gln Ile Arg Val Pro  Glu Glu Ile Gln Lys  Gly Phe Thr 
    1040                 1045                 1050             


Lys Lys  Arg Ile Asp His Arg  His His Ala Met Asp  Ala Leu Val 
    1055                 1060                 1065             


Ile Ala  Cys Ala Thr Arg Ser  His Ile Asn Tyr Ile  Ser Asn Arg 
    1070                 1075                 1080             


Ser Gly  Gln Asp Arg Asn Ala  Lys Phe Glu Thr Thr  Arg Thr Asp 
    1085                 1090                 1095             


Leu Arg  Ser Lys Leu Cys Tyr  Lys Glu Asn Ser Ser  Gly Asn Asn 
    1100                 1105                 1110             


Tyr Asn  Tyr Ile Phe Asn Lys  Pro Trp Asp Thr Phe  Thr Gln Asp 
    1115                 1120                 1125             


Ala His  Arg Ala Leu Glu Asn  Ile Val Val Ser His  Lys Gln Asn 
    1130                 1135                 1140             


Leu Arg  Val Leu Thr Lys Thr  Asn Asn Tyr Thr Gln  Phe Ile Asn 
    1145                 1150                 1155             


Lys Asp  Gly Lys Lys Asp Leu  Gln Lys Gln Val Lys  Gly Asp His 
    1160                 1165                 1170             


Phe Ala  Val Arg Lys Pro Met  His Gln Glu Thr Ile  Tyr Gly Arg 
    1175                 1180                 1185             


Val Ser  Ile Arg Ser Ile Lys  Glu Val Ala Leu Lys  Lys Ala Leu 
    1190                 1195                 1200             


Glu Asn  Trp Lys Gln Ile Val  Asp Arg Thr Leu Lys  Asp Lys Ile 
    1205                 1210                 1215             


Arg Glu  Leu Ile Gly Ala Tyr  Gly Lys Tyr Asp Ala  Gln Thr Ile 
    1220                 1225                 1230             


Leu Lys  Tyr Phe Lys Asp Arg  Asp Tyr Lys Phe Asn  Asn Leu Lys 
    1235                 1240                 1245             


Ile Asn  Arg Val Glu Val Tyr  Glu Tyr Asp His Asn  Cys Ala Ala 
    1250                 1255                 1260             


Val Arg  Lys Ser Ile Gly Asp  Asp Leu Thr Ile Lys  Gln Ile Glu 
    1265                 1270                 1275             


Arg Ile  Thr Asp Glu Ser Ile  Arg Lys Ile Leu Met  Asn His Leu 
    1280                 1285                 1290             


Ser Asn  Tyr Asp Asp Asn Leu  Lys Glu Ala Phe Ser  Pro Glu Gly 
    1295                 1300                 1305             


Leu Met  Glu Met Asn Lys Asn  Ile Lys Glu Leu Asn  Gly Gly Lys 
    1310                 1315                 1320             


Asn His  Gln Pro Ile Tyr Lys  Val Arg Leu Phe Glu  Asp Leu Gly 
    1325                 1330                 1335             


Ser Lys  Phe Pro Leu Gly Val  Ser His Asn Asn Pro  Asp Lys Tyr 
    1340                 1345                 1350             


Ala Ile  Ala Ala Lys Gly Thr  Asn Leu Phe Phe Gly  Ile Tyr Glu 
    1355                 1360                 1365             


Asp Gln  Glu Gly Lys Arg Met  Phe Asp Ser Ile Pro  Leu Asn Ile 
    1370                 1375                 1380             


Val Ile  Asp Arg Leu Lys Glu  Lys Lys Ser Pro Val  Pro Glu Thr 
    1385                 1390                 1395             


Tyr Asn  Glu Ser Lys Leu Lys  Phe His Leu Ser Pro  Asn Asp Leu 
    1400                 1405                 1410             


Val Tyr  Val Pro Thr Asp Glu  Glu Gln Lys Gln Pro  Glu Leu Val 
    1415                 1420                 1425             


Asp Val  Asp His Leu Ser Asp  Glu Gln Lys Gly Arg  Val Tyr Lys 
    1430                 1435                 1440             


Ala Val  Ser Phe Thr Gly Asn  Arg Ala Phe Phe Val  Asn His Arg 
    1445                 1450                 1455             


Val Ser  Lys Val Ile His Asp  Tyr Val Glu Phe Gly  Thr Lys Asn 
    1460                 1465                 1470             


Lys Ile  Glu Asn Asp Asp Asp  Lys Arg Ser Leu Lys  His Ile Cys 
    1475                 1480                 1485             


Trp Lys  Leu Lys Val Asn Arg  Leu Gly Glu Ile Thr  Asp Val Lys 
    1490                 1495                 1500             


Arg 
    


<210> 75
<211> 1504
<212> PRT
<213> Bacteroides dorei


<220>
<223> Bacteroides dorei DSM 17855

<400> 75
Met Lys Asn Ile Val Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Val Val Asn Gly Ser Val Asn Asp Asp Gly Ser Glu Gln Leu Val 
            20                  25                  30          


Lys Ile Gln Ala Ser Gly Ser Arg Ile Ile Pro Met Asp Ala Ala Met 
        35                  40                  45              


Ile Gly Asp Phe Asn Lys Gly Asn Ser Ile Ser Gln Thr Ala Glu Arg 
    50                  55                  60                  


Thr Arg Leu Arg Gly Val Arg Arg Leu Ser Glu Arg Tyr Leu Leu Arg 
65                  70                  75                  80  


Arg Glu Arg Leu His Arg Ile Leu Asp Ile Leu Gly Phe Leu Pro Phe 
                85                  90                  95      


His Phe Ala Gln Asp Leu Asp Arg His Gly Lys Ile Val Lys Gly Lys 
            100                 105                 110         


Glu Pro Lys Leu Ala Trp Arg Lys Asn Glu Ala Gly Gln Phe Glu Phe 
        115                 120                 125             


Ile Phe Gln Asp Ser Phe Lys Glu Met Leu Glu Asp Phe Lys Leu Asn 
    130                 135                 140                 


Tyr Pro Asn Leu Ile Thr Asp Asp Lys Lys Val Pro Tyr Asp Trp Thr 
145                 150                 155                 160 


Ile Tyr Tyr Leu Arg Lys Lys Gly Leu Thr Ser Lys Ile Ser Lys Glu 
                165                 170                 175     


Glu Leu Ala Trp Ile Leu Leu Asn Phe Asn Gln Lys Arg Gly Tyr Tyr 
            180                 185                 190         


Gln Leu Arg Gly Glu Glu Glu Glu Glu Asn Lys Asp Lys Leu Val Glu 
        195                 200                 205             


Phe Tyr Ala Leu Lys Val Val Ala Val Glu Asp Ser Gly Glu Lys Lys 
    210                 215                 220                 


Gly Lys Asp Ile Trp Tyr Asn Val His Leu Glu Asn Gly Trp Val Tyr 
225                 230                 235                 240 


Arg Arg Thr Ser Asn Met Ser Leu Asp Trp Val Gly Lys Thr Lys Glu 
                245                 250                 255     


Phe Ile Val Thr Thr Asp Leu Glu Lys Asp Gly Thr Pro Lys Lys Asp 
            260                 265                 270         


Lys Glu Gly Asn Val Lys Arg Ser Phe Arg Ala Pro Lys Glu Asp Asp 
        275                 280                 285             


Trp Ser Leu Val Lys Lys Lys Thr Glu Ala Asp Ile Asp Gln Thr His 
    290                 295                 300                 


Lys Thr Val Gly Ala Tyr Ile Tyr Asp Thr Leu Leu Gly Asn Pro Ser 
305                 310                 315                 320 


Gln Lys Ile Arg Gly Arg Leu Val Arg Thr Ile Glu Arg Lys Tyr Tyr 
                325                 330                 335     


Lys Glu Glu Leu Lys Leu Ile Leu Glu Lys Gln Lys Glu Phe His Leu 
            340                 345                 350         


Glu Leu Gln Asp Arg Ala Leu Tyr Ala Ala Cys Ile Glu Glu Leu Tyr 
        355                 360                 365             


Pro Ile Asn Glu Ala His Arg Asn Asn Val Gly Asn Arg Asp Phe Thr 
    370                 375                 380                 


Tyr Leu Phe Leu Glu Asp Ile Leu Phe Tyr Gln Arg Pro Leu Lys Ser 
385                 390                 395                 400 


Lys Lys Ser Leu Ile Asp Asn Cys Pro Tyr Glu Glu Asn Gln Gly Leu 
                405                 410                 415     


Asp Lys Glu Thr Gly Glu Ile Lys Ser Phe Pro Val Lys Cys Ile Ala 
            420                 425                 430         


Lys Ser His Pro Leu Phe Gln Glu Phe Arg Leu Trp Gln Phe Ile Ile 
        435                 440                 445             


Asn Leu Arg Ile Tyr Arg Lys Asp Leu Ala Gln Asp Val Asp Val Thr 
    450                 455                 460                 


Asn Glu Leu Leu Lys Thr Glu Glu Asp Tyr Val Ala Leu Phe Asp Trp 
465                 470                 475                 480 


Leu Asn Gly Lys Lys Glu Ile Asp Gln Lys Ala Phe Leu Lys Tyr Pro 
                485                 490                 495     


Val Phe Gly Leu Lys Lys Glu Ile Glu Asn Tyr Arg Trp Asn Tyr Val 
            500                 505                 510         


Gln Asp Lys Pro Tyr Pro Cys Asn Glu Thr Arg Ser Leu Met Leu Ala 
        515                 520                 525             


Arg Leu Glu Lys Cys Asp Ile Ser Ile Glu Phe Leu Thr Lys Glu Asn 
    530                 535                 540                 


Glu Glu Ala Leu Trp His Ile Leu Tyr Ser Val Glu Asp Lys Asn Glu 
545                 550                 555                 560 


Ile Val Lys Ala Leu Gln Lys Phe Ala Asp Lys His Asp Leu Asn Ala 
                565                 570                 575     


Ser Phe Val Asp Val Phe Gln Lys Phe Pro Pro Phe Lys Lys Glu Tyr 
            580                 585                 590         


Gly Ser Tyr Ser Ala Lys Ala Ile Lys Lys Leu Leu Pro Leu Met Arg 
        595                 600                 605             


Met Gly Lys Tyr Trp Ser Glu Asn Ser Ile Asp Lys Gly Thr Arg Glu 
    610                 615                 620                 


Arg Ile Asp Lys Ile Ile Thr Gly Glu Tyr Asp Glu Lys Ile Glu Asn 
625                 630                 635                 640 


Arg Val Arg Glu Lys Ala Ile His Leu Ala Asp Val Ser Asp Phe Lys 
                645                 650                 655     


Gly Leu Pro Leu Trp Leu Val Cys Tyr Ile Val Tyr Gly Arg His Ser 
            660                 665                 670         


Glu Ala Lys Glu Ile Ile Gln Trp Lys Ser Pro Ala Asp Ile Asp Ser 
        675                 680                 685             


Tyr Leu Arg Ser Phe Lys Gln His Ser Leu Arg Asn Pro Ile Val Glu 
    690                 695                 700                 


Gln Ile Ile Ile Glu Thr Leu Arg Val Val Arg Asp Ile Trp Lys Gln 
705                 710                 715                 720 


Val Gly Asn Ile Asp Glu Ile His Val Glu Leu Gly Arg Glu Met Lys 
                725                 730                 735     


Asn Pro Ala Asp Lys Arg Lys Lys Met Thr Gln Gln Met Ser Glu Asn 
            740                 745                 750         


Glu Asn Thr Asn Leu Arg Ile Lys Tyr Leu Leu Thr Glu Phe Leu Asn 
        755                 760                 765             


Pro Glu Tyr Glu Val Glu Asn Val Arg Pro Tyr Ser Pro Ser Gln Gln 
    770                 775                 780                 


Asp Ile Leu Arg Ile Tyr Glu Glu Gly Val Leu Asn Ser Val Ser Asp 
785                 790                 795                 800 


Leu Pro Glu Glu Ile Ser Asp Ile Leu Lys Lys Phe Thr Glu Thr Asp 
                805                 810                 815     


Leu Lys Lys Arg Pro Ser Arg Ser Glu Val Leu Arg Tyr Lys Leu Trp 
            820                 825                 830         


Leu Glu Gln Lys Tyr Arg Ser Pro Tyr Thr Gly Glu Val Ile Pro Leu 
        835                 840                 845             


Gly Lys Leu Phe Thr Pro Ala Tyr Glu Ile Glu His Val Ile Pro Gln 
    850                 855                 860                 


Ser Tyr Tyr Phe Asp Asp Ser Phe Ser Asn Lys Val Ile Cys Glu Ala 
865                 870                 875                 880 


Glu Val Asn Lys Leu Lys Ser Asn Leu Leu Gly His Glu Phe Ile Val 
                885                 890                 895     


Lys His His Gly Glu Ile Val Glu Leu Pro Phe Gly Lys Lys Val Arg 
            900                 905                 910         


Ile Phe Thr Val Asp Glu Tyr Glu Gln Phe Val Lys Asp Asn Tyr Ser 
        915                 920                 925             


Arg Thr Arg Ser Lys Met Lys Lys Leu Leu Met Asp Asp Ile Pro Glu 
    930                 935                 940                 


Glu Phe Val Thr Arg Gln Leu Asn Asp Ser Arg Tyr Ile Ser Lys Val 
945                 950                 955                 960 


Val Lys Ser Leu Leu Ser Asn Ile Val Arg Glu Lys Gly Glu Glu Glu 
                965                 970                 975     


Ala Ile Ser Lys Asn Val Ile Pro Cys Thr Gly Gly Val Thr Asp Arg 
            980                 985                 990         


Leu Lys Lys Asp Trp Gly Ile Asn  Glu Val Trp Asn Lys  Ile Ile Leu 
        995                 1000                 1005             


Pro Arg  Phe Gln Arg Leu Asn  Glu Leu Thr Gly Thr  Asn Lys Phe 
    1010                 1015                 1020             


Thr Thr  Lys Asn Val Gly Ile  Gln Glu Ile Pro Thr  Met Pro Leu 
    1025                 1030                 1035             


Glu Leu  Gln Lys Gly Phe Asn  Lys Lys Arg Ile Asp  His Arg His 
    1040                 1045                 1050             


His Ala  Met Asp Ala Ile Ile  Ile Ala Cys Ala Asn  Arg Asn Ile 
    1055                 1060                 1065             


Ile Asn  Tyr Leu Asn Asn Lys  Ser Ala Thr Ala Lys  Ala Glu Leu 
    1070                 1075                 1080             


Ser Arg  Tyr Asp Leu Gln Lys  Met Leu Cys Asp Lys  Ala Lys Thr 
    1085                 1090                 1095             


Asp Asn  Asn Gly Asn Tyr Lys  Trp Val Ile Arg Lys  Pro Trp Ala 
    1100                 1105                 1110             


Ser Phe  Thr Gln Asp Thr Tyr  Leu Ala Leu Glu Asn  Ile Ile Val 
    1115                 1120                 1125             


Ser Phe  Lys Gln Asn Leu Arg  Val Ile Asn Lys Ala  Thr Asn Arg 
    1130                 1135                 1140             


Phe Leu  His Tyr Asn Glu Glu  Gly Lys Lys Ile Phe  Val Lys Gln 
    1145                 1150                 1155             


Gly Lys  Gly Asp Asn Trp Ala  Ile Arg Lys Ser Met  His Lys Asp 
    1160                 1165                 1170             


Thr Val  Phe Gly Glu Val Asn  Leu Arg Arg Ile Lys  Thr Val Ala 
    1175                 1180                 1185             


Leu Asn  Glu Ala Met Lys Asn  Pro Gln Ser Ile Val  Val Lys Asp 
    1190                 1195                 1200             


Phe Lys  Arg Lys Leu Leu Glu  Leu Trp Asn Leu Gly  Phe Asp Ala 
    1205                 1210                 1215             


Lys Arg  Ile Lys Lys Tyr Phe  Glu Asp Asn Arg Glu  Thr Trp Ser 
    1220                 1225                 1230             


Asp Ile  Asn Leu Ser Lys Ile  Glu Val Tyr Tyr Phe  Ser Lys Asp 
    1235                 1240                 1245             


Thr Lys  Asp Arg Phe Phe Ala  Thr Arg Lys Pro Leu  Asp Thr Ser 
    1250                 1255                 1260             


Phe Asp  Arg Lys Lys Ile Glu  Asn Asn Ile Thr Asp  Thr Gly Ile 
    1265                 1270                 1275             


Gln Lys  Ile Leu Leu Arg His  Leu Glu Leu Lys Asp  Asn Asn Pro 
    1280                 1285                 1290             


Asp Ile  Ala Phe Ser Pro Asp  Gly Ile Asp Glu Met  Asn Arg Asn 
    1295                 1300                 1305             


Ile Ile  Gln Leu Asn Asn Gly  Lys Tyr His Gln Pro  Ile Ile Lys 
    1310                 1315                 1320             


Ile Arg  Trp Tyr Glu Gln Ala  Asp Lys Phe Ala Val  Gly Gln Thr 
    1325                 1330                 1335             


Gly Asn  Lys Ser Ser Lys Phe  Val Glu Ala Ala Lys  Gly Thr Asn 
    1340                 1345                 1350             


Leu Phe  Phe Ala Val Tyr Glu  Ser Asn Ile Leu Asp  Lys Lys Thr 
    1355                 1360                 1365             


Asn Thr  Ile Ile Lys Lys Arg  Asn Tyr Ala Thr Ile  Pro Leu Asn 
    1370                 1375                 1380             


Val Ala  Ile Glu Arg Gln Lys  Gln Gly Leu Pro Val  Ala Pro Glu 
    1385                 1390                 1395             


Asp Glu  Asn Gly Asn Asp Pro  Ile Phe Val Leu Ser  Pro Asn Asp 
    1400                 1405                 1410             


Leu Val  Tyr Leu Pro Thr Asp  Asp Glu Leu Ala Asn  Gly Ile Ile 
    1415                 1420                 1425             


Ala Gln  Pro Leu Asp Arg Gly  Arg Ile Tyr Lys Met  Val Ser Ser 
    1430                 1435                 1440             


Ser Gly  Glu Gln Cys Phe Phe  Ile Lys His Ile Val  Ala Asn Val 
    1445                 1450                 1455             


Leu Val  Asp Lys Phe Glu Phe  Ser Pro Leu Asn Lys  Met Glu Arg 
    1460                 1465                 1470             


Ala Leu  Thr Gly Glu Met Ile  Lys Met Ile Cys Ile  Pro Ile Lys 
    1475                 1480                 1485             


Val Asp  Arg Leu Gly Asn Val  Leu Glu Ser Ser Ser  Ser Tyr Lys 
    1490                 1495                 1500             


Lys 
    


<210> 76
<211> 1509
<212> PRT
<213> Bacteroides eggerthii


<220>
<223> Bacteroides eggerthii 1_2_48FAA

<400> 76
Met Lys Thr Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Val Gly Trp 
1               5                   10                  15      


Ala Val Ile Asn Ser Val Ile Lys Glu Gln Ala Glu Arg Ile Trp Ile 
            20                  25                  30          


Glu Met Ala Gly Ser Arg Ile Ile Pro Met Asp Ala Ala Val Leu Gly 
        35                  40                  45              


Asp Phe Asp Lys Gly Asn Ser Ile Ser Gln Thr Ser Glu Arg Thr Arg 
    50                  55                  60                  


Leu Arg Gly Ala Arg Arg Leu Arg Glu Arg Gln Leu Leu Arg Arg Glu 
65                  70                  75                  80  


Arg Leu His Lys Val Leu Asn Ile Leu Gly Phe Leu Pro Asn His Tyr 
                85                  90                  95      


Leu Glu Tyr Ile Asp Phe Glu Lys His Pro Gly Lys Phe Leu Ala Asp 
            100                 105                 110         


Ala Glu Pro Lys Leu Ala Trp Val Lys Asp Glu Gln Gly Lys Tyr Thr 
        115                 120                 125             


Phe Leu Phe Gln Ala Ala Phe Asp Glu Met Leu Ala Asp Phe Ala Ile 
    130                 135                 140                 


His Gln Pro Ser Leu Val Ser Gly Asp Lys Lys Ile Pro Tyr Asp Trp 
145                 150                 155                 160 


Thr Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Thr Glu Met Ile Ser Lys 
                165                 170                 175     


Glu Glu Leu Ala Trp Ile Leu Leu Asn Phe Asn Gln Lys Arg Gly Tyr 
            180                 185                 190         


Tyr Gln Leu Arg Gly Glu Glu Glu Glu Asp Asn Ala Gly Lys Ser Val 
        195                 200                 205             


Glu Phe Tyr Ala Leu Lys Val Leu Thr Val Glu Ala Thr Asp Glu Lys 
    210                 215                 220                 


Lys Gly Arg Asp Val Trp Tyr Asn Val His Leu Glu Asn Gly Trp Ile 
225                 230                 235                 240 


Tyr Arg Arg Ser Ser Ser Val Pro Leu Asp Trp Glu Gly Gln Val Lys 
                245                 250                 255     


Glu Phe Ile Val Thr Thr Asp Leu Asn Pro Asp Gly Thr Pro Lys Leu 
            260                 265                 270         


Asp Lys Tyr Gly Glu Val Lys Arg Ser Phe Arg Ala Pro Lys Glu Asp 
        275                 280                 285             


Asp Trp Met Leu Ile Lys Lys Arg Thr Glu Ala Asp Ile Ala Asn Thr 
    290                 295                 300                 


His Lys Thr Val Gly Ala Tyr Ile Tyr Asp Thr Leu Leu Gln Lys Pro 
305                 310                 315                 320 


Gln Gln Lys Ile Ile Gly Lys Leu Val Lys Thr Val Glu Arg Lys Leu 
                325                 330                 335     


Tyr Arg Asp Glu Leu Ser Leu Ile Leu Gln Lys Gln Cys Ala Phe His 
            340                 345                 350         


Ala Glu Leu Gln Asp Arg Ala Leu Tyr Ala Arg Cys Val Glu Ala Leu 
        355                 360                 365             


Tyr Pro Ser Asn Glu Val Arg Arg Lys Asn Ile Ala Asn Arg Asp Phe 
    370                 375                 380                 


Val Tyr Leu Leu Met Asp Asp Ile Leu Phe Tyr Gln Arg Pro Leu Lys 
385                 390                 395                 400 


Thr Lys Lys Ser Leu Ile Ala Asn Cys Pro Tyr Glu Glu Asn Glu Tyr 
                405                 410                 415     


Val Asp Arg Glu Thr Gly Glu Ile Lys Lys Thr Pro Leu Lys Cys Ile 
            420                 425                 430         


Ala Lys Ser His Pro Leu Phe Gln Glu Phe Arg Leu Trp Asn Phe Leu 
        435                 440                 445             


Ser Asn Ile Arg Ile Tyr Gln Lys Glu Lys Glu Ile Asn Gly Thr Leu 
    450                 455                 460                 


His Leu Asp Val Asp Val Thr Ala Glu Phe Leu Lys Thr Glu Asp Asp 
465                 470                 475                 480 


Tyr Val Ala Leu Phe Asp Trp Leu Asn Ser Arg Lys Glu Ile Glu Gln 
                485                 490                 495     


Lys Thr Phe Leu Lys Tyr Pro Lys Phe Gly Leu Lys Lys Glu Ile Ser 
            500                 505                 510         


Asn Tyr Arg Trp Asn Tyr Val Glu Asp Lys Gln Tyr Pro Cys Asn Glu 
        515                 520                 525             


Thr Arg His Ala Ile Leu Ser Ser Leu Glu Lys Ala Asn Val Cys Ile 
    530                 535                 540                 


Asp Phe Leu Ser Asn Glu Lys Glu Val Ala Leu Trp His Ile Leu Tyr 
545                 550                 555                 560 


Ser Val Ser Asp Lys Gln Glu Ile Glu Lys Ala Leu Arg Thr Phe Ala 
                565                 570                 575     


Ala Lys Asn Gly Leu Asp Glu Ser Phe Val Glu Ala Phe Lys Lys Phe 
            580                 585                 590         


Pro Pro Phe Lys Ser Glu Tyr Gly Ala Tyr Ser Ala Lys Ala Ile Lys 
        595                 600                 605             


Lys Met Leu Pro Leu Met Arg Cys Gly Lys Tyr Trp Asp Val Ser Ser 
    610                 615                 620                 


Ile Asp Asp Thr Thr Lys Glu Arg Ile Lys Lys Ile Val Thr Gly Glu 
625                 630                 635                 640 


Tyr Asp Glu Arg Ile Ser Val Lys Val Arg Asp Lys Val Met Asn Leu 
                645                 650                 655     


Ser Asp Ile Ser Cys Phe Arg Arg Leu Pro Leu Trp Leu Ala Cys Tyr 
            660                 665                 670         


Ile Val Tyr Asn Arg His Ser Glu Asp Lys Glu Ala Val Lys Trp Glu 
        675                 680                 685             


Ser Pro Ala Asp Ile Asp Ala Tyr Leu Ala Ser Phe Lys Gln His Ser 
    690                 695                 700                 


Leu Arg Asn Pro Ile Val Glu Gln Val Ile Thr Glu Thr Leu Arg Val 
705                 710                 715                 720 


Val Arg Asp Ile Trp Lys Gln Val Gly Arg Ile Asp Glu Ile His Ile 
                725                 730                 735     


Glu Leu Gly Arg Glu Met Lys Asn Pro Ala Asp Lys Arg Lys Arg Met 
            740                 745                 750         


Thr Ala Gln Ile Leu Glu Asn Glu Asn Ala Asn Leu Arg Ile Lys Ala 
        755                 760                 765             


Leu Leu Ala Glu Phe Met Asn Pro Glu Tyr Glu Ile Glu Asn Val Arg 
    770                 775                 780                 


Pro Tyr Ser Pro Ser Gln Gln Glu Ile Leu Arg Ile Tyr Glu Asp Thr 
785                 790                 795                 800 


Val Leu His Ala Glu Asp Gln Leu Pro Glu Glu Ile Asp Ala Ile Leu 
                805                 810                 815     


Lys Lys Phe Asn Ser Ser Lys Val Pro Thr Lys Ser Glu Phe Leu Arg 
            820                 825                 830         


Tyr Lys Leu Trp Leu Glu Gln Lys Tyr Arg Ser Pro Tyr Thr Gly Glu 
        835                 840                 845             


Leu Ile Pro Leu Gly Lys Leu Phe Thr Ala Ala Tyr Glu Ile Glu His 
    850                 855                 860                 


Val Ile Pro Gln Ser Arg Tyr Phe Asp Asp Ser Phe Ser Asn Lys Val 
865                 870                 875                 880 


Ile Cys Glu Ser Ala Val Asn Lys Leu Lys Asp Asn Gln Leu Gly Tyr 
                885                 890                 895     


Glu Phe Ile Lys Asn His His Gly Gln Lys Val Glu Val Gly Phe Gly 
            900                 905                 910         


Lys Ser Val Glu Ile Phe Ser Val Asp Ser Tyr Glu Arg Phe Val Lys 
        915                 920                 925             


Glu Gln Tyr Ala Lys Ser Ala Val Lys Met Lys Lys Leu Leu Met Asp 
    930                 935                 940                 


Asp Ile Pro Glu Gln Phe Ile Glu Arg Gln Leu Asn Asp Ser Arg Tyr 
945                 950                 955                 960 


Ile Ser Lys Val Ile Lys Gly Leu Leu Ser Asn Ile Val Arg Glu Lys 
                965                 970                 975     


Asn Asp Ser Gly Glu Tyr Glu Pro Glu Ala Val Ser Lys Asn Ile Val 
            980                 985                 990         


Val Cys Thr Gly Ser Val Thr Asp  Arg Leu Lys Arg Asp  Trp Gly Met 
        995                 1000                 1005             


Asn Asp  Val Trp Asn Ser Ile  Val Tyr Pro Arg Phe  Glu Arg Leu 
    1010                 1015                 1020             


Asn Ser  Leu Thr Asp Thr Gln  Ser Phe Gly His Trp  Glu Asn Lys 
    1025                 1030                 1035             


Ser Gly  Lys Lys Val Phe Gln  Thr Glu Leu Pro Leu  Glu Tyr Gln 
    1040                 1045                 1050             


Lys Gly  Phe Ser Lys Lys Arg  Ile Asp His Arg His  His Ala Met 
    1055                 1060                 1065             


Asp Ala  Ile Val Ile Ala Cys  Ala Thr Arg Asn His  Val Asn Tyr 
    1070                 1075                 1080             


Leu Ser  Asn Glu Ser Ala Ser  Arg Asn Ala Lys Ile  Ser Arg Tyr 
    1085                 1090                 1095             


Asp Leu  Gln Arg Leu Leu Cys  Asp Lys Asn Arg Thr  Asp Asp Asn 
    1100                 1105                 1110             


Gly Asn  Tyr Lys Trp Val Ile  Lys Lys Pro Trp Asp  Thr Phe Thr 
    1115                 1120                 1125             


Gln Asp  Ala Arg Glu Val Leu  Ser Lys Ile Val Val  Ser Leu Lys 
    1130                 1135                 1140             


Gln Asn  Leu Arg Ile Ile Asn  Lys Thr Thr Asn Val  Tyr Arg His 
    1145                 1150                 1155             


Leu Asp  Ala Thr Gly Asn Arg  Val Tyr Glu Lys Gln  Lys Thr Gly 
    1160                 1165                 1170             


Asp Ser  Trp Ala Ile Arg Lys  Pro Met His Lys Asp  Thr Val Phe 
    1175                 1180                 1185             


Gly Ala  Val Asn Leu Arg Lys  Val Lys Val Val Arg  Leu Ser Val 
    1190                 1195                 1200             


Ala Leu  Asp Thr Pro Ala Met  Ile Val Asp Lys Arg  Val Lys Asn 
    1205                 1210                 1215             


Lys Val  Phe Glu Leu Leu Ser  Tyr Lys Tyr Asp Lys  Lys Arg Ile 
    1220                 1225                 1230             


Glu Lys  Tyr Phe Lys Glu Asn  Ala Phe Leu Trp Lys  Glu Leu Asp 
    1235                 1240                 1245             


Leu Ala  Lys Val Ala Val Tyr  Tyr Phe Thr Glu Ala  Thr Thr Glu 
    1250                 1255                 1260             


Pro Leu  Val Ala Val Arg Lys  Pro Leu Asp Ser Thr  Phe Asn Glu 
    1265                 1270                 1275             


Lys Lys  Ile Lys Glu Ser Val  Thr Asp Thr Gly Ile  Gln Lys Ile 
    1280                 1285                 1290             


Leu Leu  Asn His Leu Cys Thr  Lys Glu Gly Lys Pro  Asp Leu Ala 
    1295                 1300                 1305             


Phe Ser  Ala Glu Gly Ile Glu  Glu Met Asn Arg Asn  Leu Leu Gln 
    1310                 1315                 1320             


Leu Asn  Asn Gly Lys Ser His  Gln Pro Ile Tyr Lys  Val Arg Val 
    1325                 1330                 1335             


Tyr Glu  Pro Arg Gly Asn Lys  Phe Ser Val Gly Val  Leu Gly Asn 
    1340                 1345                 1350             


Lys Gly  Thr Lys Trp Val Glu  Ala Ala Lys Gly Thr  Asn Leu Phe 
    1355                 1360                 1365             


Phe Ala  Ile Tyr Ile Thr Glu  Asp Gly Lys Arg Thr  Tyr Glu Thr 
    1370                 1375                 1380             


Ile Pro  Leu Asn Val Val Ile  Glu Arg Glu Lys Gln  Gly Leu Val 
    1385                 1390                 1395             


Pro Val  Pro Asp Arg Asn Lys  Lys Gly Asp Lys Leu  Leu Phe Trp 
    1400                 1405                 1410             


Leu Ser  Pro Asn Asp Leu Val  Tyr Leu Pro Thr Glu  Glu Glu Arg 
    1415                 1420                 1425             


Glu Phe  Gly Arg Ile Asn Glu  Pro Ile Asp Arg Gly  Arg Ile Tyr 
    1430                 1435                 1440             


Lys Met  Val Ser Cys Thr Gly  Asn Glu Gly His Phe  Ile Pro Ala 
    1445                 1450                 1455             


Asn Val  Ala Asn Pro Ile Val  Pro Val Ile Glu Leu  Gly Ser Asn 
    1460                 1465                 1470             


Asn Lys  Ala Gln Arg Ala Trp  Thr Asn Glu Met Ile  Lys Asp Ile 
    1475                 1480                 1485             


Cys Ile  Pro Ile Lys Val Asp  Arg Leu Gly His Ile  Ile Glu Val 
    1490                 1495                 1500             


Lys Tyr  Arg Ile Asp Glu 
    1505                 


<210> 77
<211> 1526
<212> PRT
<213> Bacteroides faecis


<220>
<223> Bacteroides faecis MAJ27

<400> 77
Met Lys Lys Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Val Leu Asn Ala Ala Asp Asp Asn Ser Leu Lys Tyr Ile Glu Ala 
            20                  25                  30          


Ala Gly Ser Arg Ile Ile Pro Met Asp Ala Ala Ile Leu Gly Asp Phe 
        35                  40                  45              


Asp Arg Gly Asn Ser Ile Ser Gln Thr Ala Glu Arg Thr Arg Ile Arg 
    50                  55                  60                  


Gly Met Arg His Leu Arg Glu Arg Tyr Leu Leu Arg Arg Ala Arg Leu 
65                  70                  75                  80  


His Arg Ile Leu Asn Leu Leu Gly Phe Leu Pro Phe His Tyr Ala Gln 
                85                  90                  95      


Asp Ile Asp Arg Tyr Gly Asn Phe Ser Ala Asp Met Glu Pro Lys Ile 
            100                 105                 110         


Ala Trp Cys Lys Asn Leu Glu Gly Glu Leu Glu Phe Ile Phe Ile Glu 
        115                 120                 125             


Ser Phe Asn Glu Met Leu Glu Asp Phe Arg Lys Asn Gln Pro Glu Leu 
    130                 135                 140                 


Val Ala Asp Asn Lys Lys Val Pro Tyr Asp Trp Val Ile Tyr Tyr Leu 
145                 150                 155                 160 


Arg Lys Lys Ala Leu Glu Lys Lys Ile Ser Lys Glu Glu Leu Ala Trp 
                165                 170                 175     


Ile Leu Leu Asn Phe Asn Gln Lys Arg Gly Tyr Tyr Gln Leu Arg Gly 
            180                 185                 190         


Glu Asp Asp Asp Glu Ser Met Lys Thr Ala Lys Thr Arg Gln Tyr Phe 
        195                 200                 205             


Asp Lys Gln Ile Ile Lys Asn Ile Ile Asp Thr Asn Gln Thr Tyr Lys 
    210                 215                 220                 


Gly Gln Arg Ile Leu Ile Val Glu Leu Gln Asn Gly Asp Lys Gly Lys 
225                 230                 235                 240 


Ile Phe Lys Lys Glu Ile Pro Asp Trp Ile Gly Gln Glu Lys Asn Ile 
                245                 250                 255     


Ile Val Thr Val Asp Ile Asp Lys Asp Gly Asn Asp Lys Tyr Glu Glu 
            260                 265                 270         


Ser Gly Ser Leu Ser Cys Arg Phe Lys Ile Pro Thr Asp Ala Glu Trp 
        275                 280                 285             


Glu Ser Glu Trp Lys Leu Ile Lys Met Lys Thr Gln Lys Asp Leu Asp 
    290                 295                 300                 


Glu Ser Asn Lys Thr Val Gly Thr Tyr Ile Tyr Asp Ser Ile Leu Gln 
305                 310                 315                 320 


Asn Pro Thr Gln Lys Val Arg Gly Lys Leu Val Arg Thr Ile Glu Arg 
                325                 330                 335     


Lys Tyr Tyr Lys Ala Glu Leu Lys Gln Ile Leu Glu Lys Gln Thr Glu 
            340                 345                 350         


Phe His Ser Glu Leu Gln Asp Lys Asp Leu Tyr Ile Glu Cys Leu Asn 
        355                 360                 365             


Glu Leu Tyr Ser Asn Asn Asp Thr His Arg Asn Ala Ile Thr Asp Arg 
    370                 375                 380                 


Asp Phe Val Tyr Leu Phe Met Asn Asp Ile Leu Phe Tyr Gln Arg Pro 
385                 390                 395                 400 


Leu Lys Ser Lys Lys Ser Leu Ile Asp Asn Cys Pro Tyr Glu Arg Asn 
                405                 410                 415     


Ile Tyr Ile Asp Lys Glu Thr Gly Glu Ile Lys Tyr Ser Pro Ile Lys 
            420                 425                 430         


Cys Ile Ala Lys Ser His Pro Leu Phe Gln Glu Phe Arg Leu Trp Lys 
        435                 440                 445             


Phe Ile Ser Ser Ile Arg Ile Tyr Gln Arg Glu Ser Val Val Glu Val 
    450                 455                 460                 


Val Asp Lys Gln Leu Asp Leu Phe Ser Ser Gln Ser Thr Ser Val Gln 
465                 470                 475                 480 


Lys Leu Val Thr Asp Val Asp Val Thr Asp Lys Phe Leu Thr Cys Glu 
                485                 490                 495     


Asn Asp Tyr Val Ala Leu Phe Glu Trp Leu Asn Lys Lys Lys Ile Ile 
            500                 505                 510         


Asp Gln Lys Glu Phe Leu Lys Tyr Arg Pro Phe Gly Leu Lys Gly Asp 
        515                 520                 525             


Ile Asp Asn Tyr Arg Trp Asn Tyr Val Glu Asp Lys Ser Tyr Pro Cys 
    530                 535                 540                 


Asn Glu Thr His Ala Met Ile Leu Thr Tyr Phe Ala Lys Ala Gly Ile 
545                 550                 555                 560 


Ser Glu Asp Ile Leu Thr Lys Glu Met Glu Glu Ala Leu Trp His Ile 
                565                 570                 575     


Leu Tyr Ser Val Glu Asp Arg Gln Glu Ile Thr Lys Ala Leu Arg Thr 
            580                 585                 590         


Phe Ala Ser Lys Tyr His Leu Ser Asp Ser Phe Val Lys Val Phe Ser 
        595                 600                 605             


Asn Ile Pro Pro Phe Lys Lys Glu Tyr Gly Ser Tyr Ser Ala Lys Ala 
    610                 615                 620                 


Ile Lys Lys Leu Leu Ser Leu Met Arg Met Gly Lys Tyr Trp Ser Glu 
625                 630                 635                 640 


Asp Ala Ile Asp Val Asn Thr Arg Glu Arg Ile Asp Lys Ile Val Thr 
                645                 650                 655     


Gly Glu Tyr Asp Glu Lys Ile Arg Asp Arg Val Arg Glu Lys Thr Ile 
            660                 665                 670         


Arg Leu Asn Asp Ile Arg His Phe Arg Ala Leu Pro Asp Trp Leu Ala 
        675                 680                 685             


Cys Tyr Val Val Tyr Asp Arg His Ser Glu Thr Arg Glu Ile Thr Glu 
    690                 695                 700                 


Trp Lys Ser Pro Glu Glu Ile Asp Glu Tyr Ile Arg Asn Phe Lys Gln 
705                 710                 715                 720 


His Ser Leu Arg Asn Pro Ile Val Glu Gln Val Ile Thr Glu Thr Leu 
                725                 730                 735     


Arg Thr Val Arg Asp Ile Trp Lys Gln Val Gly Cys Ile Asp Glu Ile 
            740                 745                 750         


His Val Glu Leu Gly Arg Glu Met Lys Asn Pro Ala Asp Lys Arg Lys 
        755                 760                 765             


Arg Ile Thr Ser Gln Ile Ile Glu Asn Glu Asn Ala Asn Leu Arg Val 
    770                 775                 780                 


Lys Ala Leu Leu Thr Glu Phe Val Asn Ser Glu Phe Glu Ile Glu Asn 
785                 790                 795                 800 


Val Arg Pro Tyr Ser Leu Ser Gln Gln Asp Ile Leu Arg Ile Tyr Glu 
                805                 810                 815     


Asp Gly Val Leu Asn Ser Val Ala Glu Val Pro Gly Asp Ile Ala Gly 
            820                 825                 830         


Ile Leu Lys Lys Phe Asn Glu Asn Asp Ala Lys Lys Arg Pro Thr Thr 
        835                 840                 845             


Ser Glu Ile Leu Arg Tyr Lys Leu Trp Leu Glu Gln Lys Tyr Arg Ser 
    850                 855                 860                 


Pro Tyr Thr Gly Glu Met Ile Pro Leu Ser Lys Leu Phe Thr Ser Ala 
865                 870                 875                 880 


Tyr Glu Ile Glu His Val Ile Pro Gln Ser Arg Tyr Phe Asp Asp Ser 
                885                 890                 895     


Phe Ser Asn Lys Val Ile Cys Glu Ala Glu Val Asn Lys Leu Lys Asp 
            900                 905                 910         


Asn Ala Leu Gly Tyr Glu Phe Ile Lys Lys His His Gly Glu Lys Val 
        915                 920                 925             


Glu Leu Gly Phe Gly Lys Ile Val Glu Ile Phe Ser Val Ser Val Tyr 
    930                 935                 940                 


Glu Gln Phe Val Lys Asp Asn Tyr Ser Arg Asn Arg Gly Lys Met Lys 
945                 950                 955                 960 


Lys Leu Leu Met Asp Glu Ile Pro Glu Gln Phe Ile Glu Arg Gln Leu 
                965                 970                 975     


Asn Asp Ser Arg Tyr Ile Ser Lys Val Val Lys Thr Leu Leu Ser Asn 
            980                 985                 990         


Val Val Arg Glu Lys Ala Glu Gln  Glu Ala Val Ser Lys  Asn Val Ile 
        995                 1000                 1005             


Val Cys  Thr Gly Gly Val Thr  Asp Arg Leu Lys Lys  Asp Trp Gly 
    1010                 1015                 1020             


Ile Asn  Asp Val Trp Asn Lys  Ile Val Leu Pro Arg  Phe Leu Arg 
    1025                 1030                 1035             


Leu Asn  Glu Leu Thr Asn Ser  Thr Asn Phe Thr Ala  Lys Asn Ala 
    1040                 1045                 1050             


Ala Gly  Asn Glu Ile Pro Ala  Met Pro Leu Glu Leu  Gln Lys Gly 
    1055                 1060                 1065             


Phe Asn  Lys Lys Arg Ile Asp  His Arg His His Ala  Met Asp Ala 
    1070                 1075                 1080             


Ile Val  Ile Ala Cys Ala Asn  Arg Asn Ile Val Asn  Tyr Leu Asn 
    1085                 1090                 1095             


Asn Glu  Ser Ala Ser Arg Lys  Ala Lys Ile Ser Arg  His Asp Leu 
    1100                 1105                 1110             


Gln Ala  Ile Leu Cys Asp Lys  Val Arg Thr Asp Asp  Lys Gly Asn 
    1115                 1120                 1125             


Tyr Gln  Trp Arg Val Lys Lys  Pro Trp Asp Thr Phe  Thr Gln Asp 
    1130                 1135                 1140             


Val Tyr  Val Ala Leu Glu Asn  Ile Ile Val Ser Phe  Lys Gln Asn 
    1145                 1150                 1155             


Leu Arg  Val Ile Asn Lys Thr  Ser Asn Tyr Tyr Trp  His Tyr Glu 
    1160                 1165                 1170             


Asn Gly  Lys Lys Val Leu Val  Lys Gln Val Lys Gly  Asp Ser Trp 
    1175                 1180                 1185             


Ala Ile  Arg Lys Pro Met His  Lys Asp Thr Val Phe  Gly Glu Val 
    1190                 1195                 1200             


Asn Leu  Arg Lys Val Lys Ser  Val Ser Leu Asn Glu  Ala Leu Lys 
    1205                 1210                 1215             


Asn Pro  Gln Phe Ile Val Glu  Lys Asp Leu Lys Arg  Gln Leu Leu 
    1220                 1225                 1230             


Ser Leu  Leu Gln Gln Asn Phe  Asp Ile Lys Lys Ile  Lys Lys Tyr 
    1235                 1240                 1245             


Phe Glu  Glu His Lys Asp Ile  Trp Ser Asp Ile Ser  Leu Ser Lys 
    1250                 1255                 1260             


Met Asn  Ile Tyr Tyr Phe Thr  Lys Glu Thr Lys Asp  Arg Tyr Phe 
    1265                 1270                 1275             


Ala Thr  Arg Lys Pro Leu Asp  Ala Ser Phe Asp Lys  Lys Lys Ile 
    1280                 1285                 1290             


Glu Ser  Cys Ile Thr Asp Thr  Gly Ile Gln Gln Ile  Leu Leu Arg 
    1295                 1300                 1305             


His Leu  Glu Leu Lys Glu Asn  Asp Pro Glu Arg Ala  Phe Ser Pro 
    1310                 1315                 1320             


Asp Gly  Ile Asp Glu Met Asn  Arg Asn Ile Ile Gln  Leu Asn Lys 
    1325                 1330                 1335             


Gly Lys  Gly His His Pro Ile  Ala Lys Val Arg Val  Tyr Glu Lys 
    1340                 1345                 1350             


Ala Asp  Lys Phe Glu Val Gly  Gln Arg Gly Asn Lys  Ser Ser Lys 
    1355                 1360                 1365             


Phe Val  Glu Ala Ala Lys Gly  Thr Asn Leu Phe Phe  Ala Val Tyr 
    1370                 1375                 1380             


Glu Thr  Glu Tyr Pro Asp Glu  Lys Thr Asn Ser Ile  Val Arg Lys 
    1385                 1390                 1395             


Arg Asn  Tyr Ala Thr Ile Pro  Leu Asn Ile Ala Ile  Glu Arg Gln 
    1400                 1405                 1410             


Lys Arg  Gly Leu Ser Thr Ala  Pro Glu Asp Glu Lys  Gly Asn Val 
    1415                 1420                 1425             


Pro Ser  Phe Val Leu Ser Pro  Asn Asp Leu Val Tyr  Leu Pro Thr 
    1430                 1435                 1440             


Ser Glu  Asp Ile Val Asn Gly  His Ile Thr Gln Pro  Ile Asp Lys 
    1445                 1450                 1455             


Ser Arg  Ile Tyr Lys Met Val  Ser Ser Ser Gly Ser  Gln Cys Phe 
    1460                 1465                 1470             


Phe Ile  Lys His Asn Ile Ala  Asn Ile Ile Val Asp  Lys Tyr Glu 
    1475                 1480                 1485             


Phe Ser  Pro Leu Asn Lys Met  Glu Arg Ala Ile Ser  Asn Glu Met 
    1490                 1495                 1500             


Ile Lys  Glu Ile Cys Ile Pro  Val Lys Val Asp Arg  Leu Gly Asn 
    1505                 1510                 1515             


Ile Val  Lys Leu Gly Lys Ser  Glu 
    1520                 1525     


<210> 78
<211> 1509
<212> PRT
<213> Bacteroides fluxus


<220>
<223> Bacteroides fluxus YIT 12057

<400> 78
Met Lys Thr Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Val Gly Trp 
1               5                   10                  15      


Ala Val Ile Asn Ser Val Ile Lys Glu Gln Ala Glu Arg Ile Trp Ile 
            20                  25                  30          


Glu Met Ala Gly Ser Arg Ile Ile Pro Met Asp Ala Ala Val Leu Gly 
        35                  40                  45              


Asp Phe Asp Lys Gly Asn Ser Ile Ser Gln Thr Ser Glu Arg Thr Arg 
    50                  55                  60                  


Leu Arg Gly Val Arg Arg Leu Arg Glu Arg Gln Leu Leu Arg Arg Glu 
65                  70                  75                  80  


Arg Leu His Lys Val Leu Asn Ile Leu Gly Phe Leu Pro Asn His Tyr 
                85                  90                  95      


Leu Glu Tyr Ile Asp Phe Glu Lys His Pro Gly Lys Phe Leu Ser Asp 
            100                 105                 110         


Ala Glu Pro Lys Leu Pro Trp Val Lys Asp Glu Gln Gly Lys Tyr Thr 
        115                 120                 125             


Phe Leu Phe Gln Ala Ala Phe Asp Glu Met Leu Ala Asp Phe Ala Ile 
    130                 135                 140                 


His Gln Pro Ser Leu Val Ser Gly Asp Lys Lys Ile Pro Tyr Asp Trp 
145                 150                 155                 160 


Thr Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Thr Glu Met Ile Ser Lys 
                165                 170                 175     


Glu Glu Leu Ala Trp Ile Leu Leu Asn Phe Asn Gln Lys Arg Gly Tyr 
            180                 185                 190         


Tyr Gln Leu Arg Gly Glu Glu Glu Glu Asp Asn Ala Gly Lys Ser Val 
        195                 200                 205             


Glu Phe Tyr Ala Leu Lys Val Leu Thr Val Glu Ala Thr Asp Glu Lys 
    210                 215                 220                 


Lys Gly Arg Asp Val Trp Tyr Asn Val His Leu Glu Asn Gly Trp Ile 
225                 230                 235                 240 


Tyr Arg Arg Ser Ser Ser Val Pro Leu Asp Trp Glu Gly Gln Ile Lys 
                245                 250                 255     


Glu Phe Ile Val Thr Thr Asp Leu Asn Pro Asp Ser Thr Pro Lys Leu 
            260                 265                 270         


Asp Lys Tyr Gly Glu Val Lys Arg Ser Phe Arg Ala Pro Lys Glu Asp 
        275                 280                 285             


Asp Trp Met Leu Ile Lys Lys Arg Thr Glu Ala Asp Ile Ala Asn Thr 
    290                 295                 300                 


His Lys Thr Val Gly Ala Tyr Ile Tyr Asp Thr Leu Leu Gln Lys Pro 
305                 310                 315                 320 


Gln Gln Lys Ile Ile Gly Lys Leu Val Lys Thr Val Glu Arg Lys Leu 
                325                 330                 335     


Tyr Arg Asp Glu Leu Ser Leu Ile Leu Gln Lys Gln Cys Ala Phe His 
            340                 345                 350         


Ala Glu Leu Gln Asp Arg Thr Leu Tyr Ala Arg Cys Val Glu Ala Leu 
        355                 360                 365             


Tyr Pro Asn Asn Glu Val Gln Arg Arg Asn Ile Ala Asn Arg Asp Phe 
    370                 375                 380                 


Val Tyr Leu Leu Met Asp Asp Val Leu Phe Tyr Gln Arg Pro Leu Lys 
385                 390                 395                 400 


Thr Lys Lys Ser Leu Ile Ala Asn Cys Pro Tyr Glu Glu Asn Glu Tyr 
                405                 410                 415     


Val Asp Arg Glu Thr Gly Glu Ile Lys Lys Ala Pro Leu Lys Cys Ile 
            420                 425                 430         


Ala Lys Ser His Pro Leu Phe Gln Glu Phe Arg Leu Trp Asn Phe Leu 
        435                 440                 445             


Ser Asn Ile Arg Ile Tyr Gln Lys Glu Lys Glu Ile Asn Gly Thr Leu 
    450                 455                 460                 


His Leu Asp Val Asp Val Thr Ala Glu Phe Leu Lys Thr Glu Asp Asp 
465                 470                 475                 480 


Tyr Val Ala Leu Phe Asp Trp Leu Asn Ser Arg Lys Glu Ile Glu Gln 
                485                 490                 495     


Lys Thr Phe Leu Lys Tyr Pro Lys Phe Gly Leu Lys Lys Glu Ile Ser 
            500                 505                 510         


Asn Tyr Arg Trp Asn Tyr Val Glu Asp Lys Gln Tyr Pro Cys Asn Glu 
        515                 520                 525             


Thr Arg His Ala Ile Leu Ser Arg Leu Glu Lys Ala Asn Val Cys Ile 
    530                 535                 540                 


Asp Phe Leu Ser Asn Glu Lys Glu Val Ala Leu Trp His Ile Leu Tyr 
545                 550                 555                 560 


Ser Val Ser Asp Lys Gln Glu Ile Glu Lys Ala Leu Arg Thr Phe Ala 
                565                 570                 575     


Ala Lys Asn Gly Leu Asp Glu Ser Phe Val Glu Ala Phe Lys Lys Phe 
            580                 585                 590         


Pro Pro Phe Lys Ser Glu Tyr Gly Ala Tyr Ser Ala Lys Ala Ile Lys 
        595                 600                 605             


Lys Leu Leu Pro Leu Met Arg Cys Gly Lys Tyr Trp Asp Val Ser Ser 
    610                 615                 620                 


Ile Asp Asp Thr Thr Lys Glu Arg Ile Lys Lys Ile Val Ala Gly Glu 
625                 630                 635                 640 


Tyr Asp Glu Arg Ile Ala Val Lys Val Arg Asp Lys Val Met Asn Leu 
                645                 650                 655     


Ser Asp Ile Ser Cys Phe Lys Arg Leu Pro Leu Trp Leu Ala Cys Tyr 
            660                 665                 670         


Ile Val Tyr Asn Arg His Ser Glu Asp Lys Glu Ala Val Lys Trp Glu 
        675                 680                 685             


Ser Pro Ala Asp Ile Asp Ala Tyr Leu Ala Ser Phe Lys Gln His Ser 
    690                 695                 700                 


Leu Arg Asn Pro Ile Val Glu Gln Val Ile Thr Glu Thr Leu Arg Val 
705                 710                 715                 720 


Val Arg Asp Ile Trp Lys Gln Val Gly Arg Ile Asp Glu Ile His Ile 
                725                 730                 735     


Glu Leu Gly Arg Glu Met Lys Asn Pro Ala Asp Lys Arg Lys Arg Met 
            740                 745                 750         


Thr Ala Gln Ile Leu Glu Asn Glu Asn Ala Asn Leu Arg Ile Lys Ala 
        755                 760                 765             


Leu Leu Ala Glu Phe Met Asn Pro Glu Tyr Glu Ile Glu Asn Val Arg 
    770                 775                 780                 


Pro Tyr Ser Pro Ser Gln Gln Glu Ile Leu Arg Ile Tyr Glu Asp Met 
785                 790                 795                 800 


Val Leu His Ala Glu Asp Gln Leu Pro Glu Glu Ile Asp Ala Ile Leu 
                805                 810                 815     


Lys Lys Phe Asn Ser Ser Lys Val Pro Thr Lys Ser Glu Phe Leu Arg 
            820                 825                 830         


Tyr Lys Leu Trp Leu Glu Gln Lys Tyr Arg Ser Pro Tyr Thr Gly Glu 
        835                 840                 845             


Leu Ile Pro Leu Gly Lys Leu Phe Thr Ala Ala Tyr Glu Ile Glu His 
    850                 855                 860                 


Val Ile Pro Gln Ser Arg Tyr Phe Asp Asp Ser Phe Ser Asn Lys Val 
865                 870                 875                 880 


Ile Cys Glu Ser Ala Val Asn Lys Leu Lys Asp Asn Gln Leu Gly Tyr 
                885                 890                 895     


Glu Phe Ile Lys Asn His His Gly Gln Lys Val Glu Val Gly Phe Gly 
            900                 905                 910         


Lys Ser Val Glu Ile Phe Ser Val Asp Ser Tyr Glu Arg Phe Val Lys 
        915                 920                 925             


Glu Gln Tyr Ala Lys Ser Ala Val Lys Met Lys Lys Met Leu Met Asp 
    930                 935                 940                 


Asp Ile Pro Glu Gln Phe Ile Glu Arg Gln Leu Asn Asp Ser Arg Tyr 
945                 950                 955                 960 


Ile Ser Lys Val Ile Lys Gly Leu Leu Ser Asn Ile Val Arg Glu Lys 
                965                 970                 975     


Asn Asp Ser Gly Glu Tyr Glu Pro Glu Ala Val Ser Lys Asn Ile Val 
            980                 985                 990         


Val Cys Thr Gly Ser Val Thr Asp  Arg Leu Lys Arg Asp  Trp Gly Met 
        995                 1000                 1005             


Asn Asp  Val Trp Asn Ser Ile  Val Tyr Pro Arg Phe  Glu Arg Leu 
    1010                 1015                 1020             


Asn Ser  Leu Thr Asp Thr Gln  Ser Phe Gly His Trp  Glu Asn Lys 
    1025                 1030                 1035             


Ser Gly  Lys Lys Val Phe Gln  Thr Glu Leu Pro Leu  Glu Tyr Gln 
    1040                 1045                 1050             


Lys Gly  Phe Ser Lys Lys Arg  Ile Asp His Arg His  His Ala Met 
    1055                 1060                 1065             


Asp Ala  Ile Val Ile Ala Cys  Ala Thr Arg Asn His  Val Asn Tyr 
    1070                 1075                 1080             


Leu Ser  Asn Glu Ser Ala Ser  Arg Asn Ala Lys Ile  Ser Arg Tyr 
    1085                 1090                 1095             


Asp Leu  Gln Arg Leu Leu Cys  Asp Lys Ser Arg Thr  Asp Asp Asn 
    1100                 1105                 1110             


Gly Asn  Tyr Lys Trp Val Ile  Lys Lys Pro Trp Asp  Thr Phe Thr 
    1115                 1120                 1125             


Gln Asp  Ala Arg Glu Val Leu  Ser Lys Ile Val Val  Ser Leu Lys 
    1130                 1135                 1140             


Gln Asn  Leu Arg Ile Ile Asn  Lys Thr Thr Asn Val  Tyr Arg His 
    1145                 1150                 1155             


Leu Asp  Ala Thr Gly Asn Arg  Val Tyr Glu Lys Gln  Lys Thr Gly 
    1160                 1165                 1170             


Asp Ser  Trp Ala Ile Arg Lys  Pro Met His Lys Asp  Thr Val Phe 
    1175                 1180                 1185             


Gly Ala  Val Asn Leu Arg Lys  Val Lys Val Val Arg  Leu Ser Val 
    1190                 1195                 1200             


Ala Leu  Asp Ala Pro Thr Met  Ile Val Asp Lys Arg  Val Lys Asn 
    1205                 1210                 1215             


Lys Val  Phe Glu Leu Leu Ser  Tyr Lys Tyr Asp Lys  Lys Arg Ile 
    1220                 1225                 1230             


Glu Lys  Tyr Phe Lys Glu Asn  Ala Val Leu Trp Lys  Glu Leu Asp 
    1235                 1240                 1245             


Leu Ala  Arg Val Ala Val Tyr  Tyr Phe Thr Glu Ala  Thr Thr Glu 
    1250                 1255                 1260             


Pro Leu  Val Ala Val Arg Lys  Pro Leu Asp Ser Thr  Phe Asn Glu 
    1265                 1270                 1275             


Lys Lys  Ile Lys Glu Ser Val  Thr Asp Thr Gly Ile  Gln Lys Ile 
    1280                 1285                 1290             


Leu Leu  Asn His Leu Cys Thr  Lys Glu Gly Lys Pro  Asp Leu Ala 
    1295                 1300                 1305             


Phe Ser  Ala Glu Gly Ile Glu  Glu Met Asn Arg Asn  Leu Leu Gln 
    1310                 1315                 1320             


Leu Asn  Asn Gly Lys Arg His  Gln Pro Ile Tyr Lys  Val Arg Val 
    1325                 1330                 1335             


Tyr Glu  Pro Arg Gly Asn Lys  Phe Ser Val Gly Val  Leu Gly Asn 
    1340                 1345                 1350             


Lys Gly  Thr Lys Trp Val Glu  Ala Ala Lys Gly Thr  Asn Leu Phe 
    1355                 1360                 1365             


Phe Ala  Ile Tyr Ile Thr Glu  Asp Gly Lys Arg Thr  Tyr Glu Thr 
    1370                 1375                 1380             


Ile Pro  Leu Asn Met Val Ile  Glu Arg Glu Lys Gln  Gly Leu Ala 
    1385                 1390                 1395             


Pro Val  Pro Asp Lys Asn Glu  Lys Gly Asp Lys Leu  Leu Phe Trp 
    1400                 1405                 1410             


Leu Ser  Pro Asn Asp Leu Val  Tyr Leu Pro Thr Glu  Glu Glu Leu 
    1415                 1420                 1425             


Glu Phe  Gly Arg Ile Asn Glu  Pro Ile Asp Arg Gly  Arg Ile Tyr 
    1430                 1435                 1440             


Lys Met  Val Ser Ser Ser Gly  Asn Gln Cys Phe Phe  Ile Pro Gln 
    1445                 1450                 1455             


Ser Ile  Ser Asn Ala Ile Ile  Pro Thr Lys Glu Leu  Gly Ala Asn 
    1460                 1465                 1470             


Asn Lys  Ala Glu Arg Ser Trp  Asp Gly Ala Met Ile  Lys Asn Ile 
    1475                 1480                 1485             


Cys Ile  Pro Val Lys Val Asp  Arg Leu Gly Arg Ile  Ile Glu Val 
    1490                 1495                 1500             


Lys Tyr  Arg Ile Asn Glu 
    1505                 


<210> 79
<211> 1436
<212> PRT
<213> Bacteroides fragilis

<400> 79
Met Lys Arg Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Asn Glu Ala Glu Asn Lys Asp Glu Arg Ser Ser Ile Val 
            20                  25                  30          


Lys Leu Gly Val Arg Val Asn Pro Leu Thr Val Asp Glu Leu Thr Asn 
        35                  40                  45              


Phe Glu Lys Gly Lys Ser Ile Thr Thr Asn Ala Asp Arg Thr Leu Lys 
    50                  55                  60                  


Arg Gly Met Arg Arg Asn Leu Gln Arg Tyr Lys Leu Arg Arg Glu Thr 
65                  70                  75                  80  


Leu Thr Glu Val Leu Lys Glu His Lys Leu Ile Thr Glu Asp Thr Ile 
                85                  90                  95      


Leu Ser Glu Asn Gly Asn Arg Thr Thr Phe Glu Thr Tyr Arg Leu Arg 
            100                 105                 110         


Ala Lys Ala Val Thr Glu Glu Ile Ser Leu Glu Glu Phe Ala Arg Val 
        115                 120                 125             


Leu Leu Met Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala 
    130                 135                 140                 


Lys Gly Val Glu Glu Gly Thr Leu Ile Asp Gly Met Asp Ile Ala Arg 
145                 150                 155                 160 


Glu Leu Tyr Asn Asn Asn Leu Thr Pro Gly Glu Leu Cys Leu Gln Leu 
                165                 170                 175     


Leu Asp Ala Gly Lys Lys Phe Leu Pro Asp Phe Tyr Arg Ser Asp Leu 
            180                 185                 190         


Gln Asn Glu Leu Asp Arg Ile Trp Glu Lys Gln Lys Glu Tyr Tyr Pro 
        195                 200                 205             


Glu Ile Leu Thr Asp Val Leu Lys Glu Glu Leu Arg Gly Lys Lys Arg 
    210                 215                 220                 


Asp Ala Val Trp Ala Ile Cys Ala Lys Tyr Phe Val Trp Lys Glu Asn 
225                 230                 235                 240 


Tyr Thr Glu Trp Asn Lys Glu Lys Gly Lys Thr Glu Gln Gln Glu Arg 
                245                 250                 255     


Glu His Lys Leu Glu Gly Ile Tyr Ser Lys Arg Lys Arg Asp Glu Ala 
            260                 265                 270         


Lys Arg Glu Asn Leu Gln Trp Arg Val Asn Gly Leu Lys Glu Lys Leu 
        275                 280                 285             


Ser Leu Glu Gln Leu Val Ile Val Phe Gln Glu Met Asn Thr Gln Ile 
    290                 295                 300                 


Asn Asn Ser Ser Gly Tyr Leu Gly Ala Ile Ser Asp Arg Ser Lys Glu 
305                 310                 315                 320 


Leu Tyr Phe Asn Lys Gln Thr Val Gly Gln Tyr Gln Met Glu Met Leu 
                325                 330                 335     


Asp Lys Asn Pro Asn Ala Ser Leu Arg Asn Met Val Phe Tyr Arg Gln 
            340                 345                 350         


Asp Tyr Leu Asp Glu Phe Asn Met Leu Trp Glu Lys Gln Ala Val Tyr 
        355                 360                 365             


His Lys Glu Leu Thr Glu Glu Leu Lys Lys Glu Ile Arg Asp Ile Ile 
    370                 375                 380                 


Ile Phe Tyr Gln Arg Arg Leu Lys Ser Gln Lys Gly Leu Ile Gly Phe 
385                 390                 395                 400 


Cys Glu Phe Glu Ser Arg Gln Ile Glu Val Asp Ile Asp Gly Lys Lys 
                405                 410                 415     


Lys Ile Lys Thr Val Gly Asn Arg Val Ile Ser Arg Ser Ser Pro Leu 
            420                 425                 430         


Phe Gln Glu Phe Lys Ile Trp Gln Ile Leu Asn Asn Ile Glu Val Thr 
        435                 440                 445             


Val Val Gly Lys Lys Arg Lys Arg Arg Lys Leu Lys Glu Asn Tyr Ser 
    450                 455                 460                 


Ala Leu Phe Glu Glu Leu Asn Asp Ala Glu Gln Leu Glu Leu Asn Gly 
465                 470                 475                 480 


Ser Arg Arg Leu Cys Gln Glu Glu Lys Glu Leu Leu Ala Gln Glu Leu 
                485                 490                 495     


Phe Ile Arg Asp Lys Met Thr Lys Ser Glu Val Leu Lys Leu Leu Phe 
            500                 505                 510         


Asp Asn Pro Gln Glu Leu Asp Leu Asn Phe Lys Thr Ile Asp Gly Asn 
        515                 520                 525             


Lys Thr Gly Tyr Ala Leu Phe Gln Ala Tyr Ser Lys Met Ile Glu Met 
    530                 535                 540                 


Ser Gly His Glu Pro Val Asp Phe Lys Lys Pro Val Glu Lys Val Val 
545                 550                 555                 560 


Glu Tyr Ile Lys Ala Val Phe Asp Leu Leu Asn Trp Asn Thr Asp Ile 
                565                 570                 575     


Leu Gly Phe Asn Ser Asn Glu Glu Leu Asp Asn Gln Ser Tyr Tyr Lys 
            580                 585                 590         


Leu Trp His Leu Leu Tyr Ser Phe Glu Gly Asp Asn Thr Pro Thr Gly 
        595                 600                 605             


Asn Gly Arg Leu Ile Gln Lys Met Thr Glu Leu Tyr Gly Phe Glu Lys 
    610                 615                 620                 


Glu Tyr Ala Thr Ile Leu Ala Asn Val Ser Phe Gln Asp Asp Tyr Gly 
625                 630                 635                 640 


Ser Leu Ser Ala Lys Ala Ile His Lys Ile Leu Pro His Leu Lys Glu 
                645                 650                 655     


Gly Asn Arg Tyr Asp Val Ala Cys Val Tyr Ala Gly Tyr Arg His Ser 
            660                 665                 670         


Glu Ser Ser Leu Thr Arg Glu Glu Ile Ala Asn Lys Val Leu Lys Asp 
        675                 680                 685             


Arg Leu Met Leu Leu Pro Lys Asn Ser Leu His Asn Pro Val Val Glu 
    690                 695                 700                 


Lys Ile Leu Asn Gln Met Val Asn Val Ile Asn Val Ile Ile Asp Ile 
705                 710                 715                 720 


Tyr Gly Lys Pro Asp Glu Ile Arg Val Glu Leu Ala Arg Glu Leu Lys 
                725                 730                 735     


Lys Asn Ala Lys Glu Arg Glu Glu Leu Thr Lys Ser Ile Ala Gln Thr 
            740                 745                 750         


Thr Lys Ala His Glu Glu Tyr Lys Thr Leu Leu Gln Thr Glu Phe Gly 
        755                 760                 765             


Leu Thr Asn Val Ser Arg Thr Asp Ile Leu Arg Tyr Lys Leu Tyr Lys 
    770                 775                 780                 


Glu Leu Glu Ser Cys Gly Tyr Lys Thr Leu Tyr Ser Asn Thr Tyr Ile 
785                 790                 795                 800 


Ser Arg Glu Lys Leu Phe Ser Lys Glu Phe Asp Ile Glu His Ile Ile 
                805                 810                 815     


Pro Gln Ala Arg Leu Phe Asp Asp Ser Phe Ser Asn Lys Thr Leu Glu 
            820                 825                 830         


Ala Arg Ser Val Asn Ile Glu Lys Gly Asn Lys Thr Ala Tyr Asp Phe 
        835                 840                 845             


Val Lys Glu Lys Phe Gly Glu Ser Gly Ala Asp Asn Ser Leu Glu His 
    850                 855                 860                 


Tyr Leu Asn Asn Ile Glu Asp Leu Phe Lys Ser Gly Lys Ile Ser Lys 
865                 870                 875                 880 


Thr Lys Tyr Asn Lys Leu Lys Met Ala Glu Gln Asp Ile Pro Asp Gly 
                885                 890                 895     


Phe Ile Glu Arg Asp Leu Arg Asn Thr Gln Tyr Ile Ala Lys Lys Ala 
            900                 905                 910         


Leu Ser Met Leu Asn Glu Ile Ser His Arg Val Val Ala Thr Ser Gly 
        915                 920                 925             


Ser Val Thr Asp Lys Leu Arg Glu Asp Trp Gln Leu Ile Asp Val Met 
    930                 935                 940                 


Lys Glu Leu Asn Trp Glu Lys Tyr Lys Ala Leu Gly Leu Val Glu Tyr 
945                 950                 955                 960 


Phe Glu Asp Arg Asp Gly Arg Gln Ile Gly Arg Ile Lys Asp Trp Thr 
                965                 970                 975     


Lys Arg Asn Asp His Arg His His Ala Met Asp Ala Leu Thr Val Ala 
            980                 985                 990         


Phe Thr Lys Asp Val Phe Ile Gln  Tyr Phe Asn Asn Lys  Asn Ala Ser 
        995                 1000                 1005             


Leu Asp  Pro Asn Ala Asn Glu  His Ala Ile Lys Asn  Lys Tyr Phe 
    1010                 1015                 1020             


Gln Asn  Gly Arg Ala Ile Ala  Pro Met Pro Leu Arg  Glu Phe Arg 
    1025                 1030                 1035             


Ala Glu  Ala Lys Lys His Leu  Glu Asn Thr Leu Ile  Ser Ile Lys 
    1040                 1045                 1050             


Ala Lys  Asn Lys Val Ile Thr  Gly Asn Ile Asn Lys  Thr Arg Lys 
    1055                 1060                 1065             


Lys Gly  Gly Val Asn Lys Asn  Met Gln Gln Thr Pro  Arg Gly Gln 
    1070                 1075                 1080             


Leu His  Leu Glu Thr Ile Tyr  Gly Ser Gly Lys Gln  Tyr Leu Thr 
    1085                 1090                 1095             


Lys Glu  Glu Lys Val Asn Ala  Ser Phe Asp Met Arg  Lys Ile Gly 
    1100                 1105                 1110             


Thr Val  Ser Lys Leu Ala Tyr  Arg Asp Ala Leu Leu  Lys Arg Leu 
    1115                 1120                 1125             


Tyr Glu  Asn Asp Asn Asp Pro  Lys Lys Ala Phe Ala  Gly Lys Asn 
    1130                 1135                 1140             


Ser Leu  Asp Lys Gln Pro Ile  Trp Leu Asp Lys Glu  Gln Met Arg 
    1145                 1150                 1155             


Lys Val  Pro Glu Lys Val Lys  Ile Val Thr Leu Glu  Ala Ile Tyr 
    1160                 1165                 1170             


Thr Ile  Arg Lys Glu Ile Ser  Pro Asp Leu Lys Val  Asp Lys Val 
    1175                 1180                 1185             


Ile Asp  Val Gly Val Arg Lys  Ile Leu Ile Asp Arg  Leu Asn Glu 
    1190                 1195                 1200             


Tyr Gly  Asn Asp Ala Lys Lys  Ala Phe Ser Asn Leu  Asp Glu Asn 
    1205                 1210                 1215             


Pro Ile  Trp Leu Asn Lys Glu  Lys Gly Ile Ser Ile  Lys Arg Val 
    1220                 1225                 1230             


Thr Ile  Ser Gly Ile Ser Asn  Ala Gln Ser Leu His  Val Lys Lys 
    1235                 1240                 1245             


Asp Lys  Asp Gly Lys Pro Ile  Leu Asp Glu Asn Gly  Arg Asn Ile 
    1250                 1255                 1260             


Pro Val  Asp Phe Val Asn Thr  Gly Asn Asn His His  Val Ala Val 
    1265                 1270                 1275             


Tyr Tyr  Arg Pro Val Ile Asp  Lys Arg Gly Gln Leu  Val Val Asp 
    1280                 1285                 1290             


Glu Ala  Gly Asn Pro Lys Tyr  Glu Leu Glu Glu Val  Val Val Ser 
    1295                 1300                 1305             


Phe Phe  Glu Ala Val Thr Arg  Ala Asn Leu Gly Gln  Pro Ile Ile 
    1310                 1315                 1320             


Asp Lys  Asp Tyr Lys Thr Thr  Glu Gly Trp Gln Phe  Leu Phe Ser 
    1325                 1330                 1335             


Met Lys  Gln Asn Glu Tyr Phe  Val Phe Pro Asn Glu  Lys Thr Gly 
    1340                 1345                 1350             


Phe Asn  Pro Lys Glu Ile Asp  Leu Leu Asp Val Glu  Asn Tyr Gly 
    1355                 1360                 1365             


Leu Ile  Ser Pro Asn Leu Phe  Arg Val Gln Lys Phe  Ser Leu Lys 
    1370                 1375                 1380             


Asn Tyr  Val Phe Arg His His  Leu Glu Thr Thr Ile  Lys Asp Thr 
    1385                 1390                 1395             


Ser Ser  Ile Leu Arg Gly Ile  Thr Trp Ile Asp Phe  Arg Ser Ser 
    1400                 1405                 1410             


Lys Gly  Leu Asp Thr Ile Val  Lys Val Arg Val Asn  His Ile Gly 
    1415                 1420                 1425             


Gln Ile  Val Ser Val Gly Glu  Tyr 
    1430                 1435     


<210> 80
<211> 1436
<212> PRT
<213> Bacteroides sp.

<400> 80
Met Lys Arg Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Asn Glu Ala Glu Asn Lys Asp Glu Arg Ser Ser Ile Val 
            20                  25                  30          


Lys Leu Gly Val Arg Val Asn Pro Leu Thr Val Asp Glu Leu Thr Asn 
        35                  40                  45              


Phe Glu Lys Gly Lys Ser Ile Thr Thr Asn Ala Asp Arg Thr Leu Lys 
    50                  55                  60                  


Arg Gly Met Arg Arg Asn Leu Gln Arg Tyr Lys Leu Arg Arg Glu Thr 
65                  70                  75                  80  


Leu Thr Glu Val Leu Lys Glu His Lys Leu Ile Thr Glu Asp Thr Ile 
                85                  90                  95      


Leu Ser Glu Asn Gly Asn Arg Thr Thr Phe Glu Thr Tyr Arg Leu Arg 
            100                 105                 110         


Ala Lys Ala Val Thr Glu Glu Ile Ser Leu Glu Glu Phe Ala Arg Val 
        115                 120                 125             


Leu Leu Met Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala 
    130                 135                 140                 


Lys Gly Val Glu Glu Gly Thr Leu Ile Asp Gly Met Asp Ile Ala Arg 
145                 150                 155                 160 


Glu Leu Tyr Asn Asn Asn Leu Thr Pro Gly Glu Leu Cys Leu Gln Leu 
                165                 170                 175     


Leu Asp Ala Gly Lys Lys Phe Leu Pro Asp Phe Tyr Arg Ser Asp Leu 
            180                 185                 190         


Gln Asn Glu Leu Asp Arg Ile Trp Glu Lys Gln Lys Glu Tyr Tyr Pro 
        195                 200                 205             


Glu Ile Leu Thr Asp Val Leu Lys Glu Glu Leu Arg Gly Lys Lys Arg 
    210                 215                 220                 


Asp Ala Val Trp Ala Ile Cys Ala Lys Tyr Phe Val Trp Lys Glu Asn 
225                 230                 235                 240 


Tyr Thr Glu Trp Asn Lys Glu Lys Gly Lys Thr Glu Gln Gln Glu Arg 
                245                 250                 255     


Glu His Lys Leu Glu Gly Ile Tyr Ser Lys Arg Lys Arg Asp Glu Ala 
            260                 265                 270         


Lys Arg Glu Asn Leu Gln Trp Arg Val Asn Gly Leu Lys Glu Lys Leu 
        275                 280                 285             


Ser Leu Glu Gln Leu Val Ile Val Phe Gln Glu Met Asn Thr Gln Ile 
    290                 295                 300                 


Asn Asn Ser Ser Gly Tyr Leu Gly Ala Ile Ser Asp Arg Ser Lys Glu 
305                 310                 315                 320 


Leu Tyr Phe Asn Lys Gln Thr Val Gly Gln Tyr Gln Met Glu Met Leu 
                325                 330                 335     


Asp Lys Asn Pro Asn Ala Ser Leu Arg Asn Met Val Phe Tyr Arg Gln 
            340                 345                 350         


Asp Tyr Leu Asp Glu Phe Asn Met Leu Trp Glu Lys Gln Ala Val Tyr 
        355                 360                 365             


His Lys Glu Leu Thr Glu Glu Leu Lys Lys Glu Ile Arg Asp Ile Ile 
    370                 375                 380                 


Ile Phe Tyr Gln Arg Arg Leu Lys Ser Gln Lys Gly Leu Ile Gly Phe 
385                 390                 395                 400 


Cys Glu Phe Glu Ser Arg Gln Ile Glu Val Asp Ile Asp Gly Lys Lys 
                405                 410                 415     


Lys Ile Lys Thr Val Gly Asn Arg Val Ile Ser Arg Ser Ser Pro Leu 
            420                 425                 430         


Phe Gln Glu Phe Lys Ile Trp Gln Ile Leu Asn Asn Ile Glu Val Thr 
        435                 440                 445             


Val Val Gly Lys Lys Arg Lys Arg Arg Lys Leu Lys Glu Asn Tyr Ser 
    450                 455                 460                 


Ala Leu Phe Glu Glu Leu Asn Asp Ala Glu Gln Leu Glu Leu Asn Gly 
465                 470                 475                 480 


Ser Arg Arg Leu Cys Gln Glu Glu Lys Glu Leu Leu Ala Gln Glu Leu 
                485                 490                 495     


Phe Ile Arg Asp Lys Met Thr Lys Ser Glu Val Leu Lys Leu Leu Phe 
            500                 505                 510         


Asp Asn Pro Gln Glu Leu Asp Leu Asn Phe Lys Thr Ile Asp Gly Asn 
        515                 520                 525             


Lys Thr Gly Tyr Ala Leu Phe Gln Ala Tyr Ser Lys Met Ile Glu Met 
    530                 535                 540                 


Ser Gly His Glu Pro Val Asp Phe Lys Lys Pro Val Glu Lys Val Val 
545                 550                 555                 560 


Glu Tyr Ile Lys Ala Val Phe Asp Leu Leu Asn Trp Asn Thr Asp Ile 
                565                 570                 575     


Leu Gly Phe Asn Ser Asn Glu Glu Leu Asp Asn Gln Pro Tyr Tyr Lys 
            580                 585                 590         


Leu Trp His Leu Leu Tyr Ser Phe Glu Gly Asp Asn Thr Pro Thr Gly 
        595                 600                 605             


Asn Gly Arg Leu Ile Gln Lys Met Thr Glu Leu Tyr Gly Phe Glu Lys 
    610                 615                 620                 


Glu Tyr Ala Thr Ile Leu Ala Asn Val Ser Phe Gln Asp Asp Tyr Gly 
625                 630                 635                 640 


Ser Leu Ser Ala Lys Ala Ile His Lys Ile Leu Pro His Leu Lys Glu 
                645                 650                 655     


Gly Asn Arg Tyr Asp Val Ala Cys Val Tyr Ala Gly Tyr Arg His Ser 
            660                 665                 670         


Glu Ser Ser Leu Thr Arg Glu Glu Ile Ala Asn Lys Val Leu Lys Asp 
        675                 680                 685             


Arg Leu Met Leu Leu Pro Lys Asn Ser Leu His Asn Pro Val Val Glu 
    690                 695                 700                 


Lys Ile Leu Asn Gln Met Val Asn Val Ile Asn Val Ile Ile Asp Ile 
705                 710                 715                 720 


Tyr Gly Lys Pro Asp Glu Ile Arg Val Glu Leu Ala Arg Glu Leu Lys 
                725                 730                 735     


Lys Asn Ala Lys Glu Arg Glu Glu Leu Thr Lys Ser Ile Ala Gln Thr 
            740                 745                 750         


Thr Lys Ala His Glu Glu Tyr Lys Thr Leu Leu Gln Thr Glu Phe Gly 
        755                 760                 765             


Leu Thr Asn Val Ser Arg Thr Asp Ile Leu Arg Tyr Lys Leu Tyr Lys 
    770                 775                 780                 


Glu Leu Glu Ser Cys Gly Tyr Lys Thr Leu Tyr Ser Asn Thr Tyr Ile 
785                 790                 795                 800 


Ser Arg Glu Lys Leu Phe Ser Lys Glu Phe Asp Ile Glu His Ile Ile 
                805                 810                 815     


Pro Gln Ala Arg Leu Phe Asp Asp Ser Phe Ser Asn Lys Thr Leu Glu 
            820                 825                 830         


Ala Arg Ser Val Asn Ile Glu Lys Gly Asn Lys Thr Ala Tyr Asp Phe 
        835                 840                 845             


Val Lys Glu Lys Phe Gly Glu Ser Gly Ala Asp Asn Ser Leu Glu His 
    850                 855                 860                 


Tyr Leu Asn Asn Ile Glu Asp Leu Phe Lys Ser Gly Lys Ile Ser Lys 
865                 870                 875                 880 


Thr Lys Tyr Asn Lys Leu Lys Met Ala Glu Gln Asp Ile Pro Asp Gly 
                885                 890                 895     


Phe Ile Glu Arg Asp Leu Arg Asn Thr Gln Tyr Ile Ala Lys Lys Ala 
            900                 905                 910         


Leu Ser Met Leu Asn Glu Ile Ser His Arg Val Val Ala Thr Ser Gly 
        915                 920                 925             


Ser Val Thr Asp Lys Leu Arg Glu Asp Trp Gln Leu Ile Asp Val Met 
    930                 935                 940                 


Lys Glu Leu Asn Trp Glu Lys Tyr Lys Ala Leu Gly Leu Val Glu Tyr 
945                 950                 955                 960 


Phe Glu Asp Arg Asp Gly Arg Gln Ile Gly Arg Ile Lys Asp Trp Thr 
                965                 970                 975     


Lys Arg Asn Asp His Arg His His Ala Met Asp Ala Leu Thr Val Ala 
            980                 985                 990         


Phe Thr Lys Asp Val Phe Ile Gln  Tyr Phe Asn Asn Lys  Asn Ala Ser 
        995                 1000                 1005             


Leu Asp  Pro Asn Ala Asn Glu  His Ala Ile Lys Asn  Lys Tyr Phe 
    1010                 1015                 1020             


Gln Asn  Gly Arg Ala Ile Ala  Pro Met Pro Leu Arg  Glu Phe Arg 
    1025                 1030                 1035             


Ala Glu  Ala Lys Lys His Leu  Glu Asn Thr Leu Ile  Ser Ile Lys 
    1040                 1045                 1050             


Ala Lys  Asn Lys Val Ile Thr  Gly Asn Ile Asn Lys  Thr Arg Lys 
    1055                 1060                 1065             


Lys Gly  Gly Val Asn Lys Asn  Met Gln Gln Thr Pro  Arg Gly Gln 
    1070                 1075                 1080             


Leu His  Leu Glu Thr Ile Tyr  Gly Ser Gly Lys Gln  Tyr Leu Thr 
    1085                 1090                 1095             


Lys Glu  Glu Lys Val Asn Ala  Ser Phe Asp Met Arg  Lys Ile Gly 
    1100                 1105                 1110             


Thr Val  Ser Lys Ser Ala Tyr  Arg Asp Ala Leu Leu  Lys Arg Leu 
    1115                 1120                 1125             


Tyr Glu  Asn Asp Asn Asp Pro  Lys Lys Ala Phe Ala  Gly Lys Asn 
    1130                 1135                 1140             


Ser Leu  Asp Lys Gln Pro Ile  Trp Leu Asp Lys Glu  Gln Met Arg 
    1145                 1150                 1155             


Lys Val  Pro Glu Lys Val Lys  Ile Val Thr Leu Glu  Ala Ile Tyr 
    1160                 1165                 1170             


Thr Ile  Arg Lys Glu Ile Ser  Pro Asp Leu Lys Val  Asp Lys Val 
    1175                 1180                 1185             


Ile Asp  Val Gly Val Arg Lys  Ile Leu Ile Asp Arg  Leu Asn Glu 
    1190                 1195                 1200             


Tyr Gly  Asn Asp Ala Lys Lys  Ala Phe Ser Asn Leu  Asp Lys Asn 
    1205                 1210                 1215             


Pro Ile  Trp Leu Asn Lys Glu  Lys Gly Ile Ser Ile  Lys Arg Val 
    1220                 1225                 1230             


Thr Ile  Ser Gly Ile Ser Asn  Ala Gln Ser Leu His  Val Lys Lys 
    1235                 1240                 1245             


Asp Lys  Asp Gly Lys Pro Ile  Leu Asp Glu Asn Gly  Arg Asn Ile 
    1250                 1255                 1260             


Pro Val  Asp Phe Val Asn Thr  Gly Asn Asn His His  Val Ala Val 
    1265                 1270                 1275             


Tyr Tyr  Arg Pro Val Ile Asp  Lys Arg Gly Gln Leu  Val Val Asp 
    1280                 1285                 1290             


Glu Ala  Gly Asn Pro Lys Tyr  Glu Leu Glu Glu Val  Val Val Ser 
    1295                 1300                 1305             


Phe Phe  Glu Ala Val Thr Arg  Ala Asn Leu Gly Leu  Pro Ile Ile 
    1310                 1315                 1320             


Asp Lys  Asp Tyr Lys Thr Thr  Glu Gly Trp Gln Phe  Leu Phe Ser 
    1325                 1330                 1335             


Met Lys  Gln Asn Glu Tyr Phe  Val Phe Pro Asn Glu  Lys Thr Gly 
    1340                 1345                 1350             


Phe Asn  Pro Lys Glu Ile Asp  Leu Leu Asp Val Glu  Asn Tyr Gly 
    1355                 1360                 1365             


Leu Ile  Ser Pro Asn Leu Phe  Arg Val Gln Lys Phe  Ser Leu Lys 
    1370                 1375                 1380             


Asn Tyr  Val Phe Arg His His  Leu Glu Thr Thr Ile  Lys Asp Thr 
    1385                 1390                 1395             


Ser Ser  Ile Leu Arg Gly Ile  Thr Trp Ile Asp Phe  Arg Ser Ser 
    1400                 1405                 1410             


Lys Gly  Leu Asp Thr Ile Val  Lys Val Arg Val Asn  His Ile Gly 
    1415                 1420                 1425             


Gln Ile  Val Ser Val Gly Glu  Tyr 
    1430                 1435     


<210> 81
<211> 1512
<212> PRT
<213> Bacteroides nordii


<220>
<223> Bacteroides nordii CL02T12C05

<400> 81
Met Lys Asn Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Val Ile Asn Ser Glu Glu Asp Gly Pro Ile Val Lys Lys Arg Ile 
            20                  25                  30          


Glu Leu Ala Gly Ser Arg Ile Ile Pro Met Asp Ala Ala Val Leu Gly 
        35                  40                  45              


Asn Phe Asp Ser Gly Val Thr Lys Ser Gln Thr Ala Glu Arg Thr Ser 
    50                  55                  60                  


Phe Arg Ser Ile Arg Arg Leu Arg Glu Arg Gln Leu Leu Arg Arg Glu 
65                  70                  75                  80  


Arg Leu His Lys Val Leu Gln Ile Leu Gly Phe Leu Pro Glu His Tyr 
                85                  90                  95      


Val Asn Asp Ile Asp Phe Glu Asn His Pro Gly Lys Ile Lys Arg Asn 
            100                 105                 110         


Thr Glu Pro Lys Leu Pro Trp Arg Lys Asn Ser Met Gly Gln Phe Glu 
        115                 120                 125             


Phe Ile Phe Gln Asp Ser Phe Glu Ala Met Leu Thr Asp Phe Ala Thr 
    130                 135                 140                 


His Gln Pro Val Phe Val Ser Glu Gly Lys Lys Val Pro Tyr Asp Trp 
145                 150                 155                 160 


Thr Leu Tyr Tyr Leu Arg Lys Lys Ala Leu Thr Glu Gly Ile Ser Lys 
                165                 170                 175     


Glu Glu Leu Ala Trp Leu Ile Leu Asn Phe Asn Gln Lys Arg Gly Tyr 
            180                 185                 190         


Tyr Gln Leu Arg Gly Glu Glu Glu Glu Glu Gln Ser Asn Lys Leu Val 
        195                 200                 205             


Glu Phe Tyr Ala Leu Arg Val Val Lys Val Glu Ala Thr Asp Asp Lys 
    210                 215                 220                 


Lys Gly Lys Asp Thr Trp Tyr Asn Val His Leu Glu Asn Gly Trp Ile 
225                 230                 235                 240 


Tyr Arg Arg Thr Ser Asn Ile Pro Leu Asp Trp Glu Gly Lys Val Lys 
                245                 250                 255     


Glu Phe Ile Val Thr Thr Asp Leu Asn Glu Asp Gly Thr Pro Lys Leu 
            260                 265                 270         


Asp Lys Tyr Gly Glu Val Lys Arg Ser Phe Arg Ala Pro Lys Glu Asp 
        275                 280                 285             


Asp Trp Thr Leu Ile Lys Lys Lys Thr Glu Ser Asp Ile Ala Asn Ser 
    290                 295                 300                 


His Lys Thr Val Gly Cys Tyr Ile Tyr Asp Ala Leu Leu Gln Asn Pro 
305                 310                 315                 320 


His Gln Lys Ile Lys Gly Arg Leu Val Arg Thr Val Glu Arg Lys Phe 
                325                 330                 335     


Tyr Lys Glu Glu Leu Arg Leu Ile Leu Glu Lys Gln Leu Ser Phe His 
            340                 345                 350         


Pro Glu Leu Gln Asp Arg Asp Leu Tyr Arg Ala Cys Ile Asp Ala Leu 
        355                 360                 365             


Tyr Val Ser Asn Glu Ala His Lys Asn Asn Ile Ser Gly Arg Asp Phe 
    370                 375                 380                 


Val Tyr Leu Phe Ile Asp Asp Ile Ile Phe Tyr Gln Arg Pro Leu Lys 
385                 390                 395                 400 


Thr Lys Lys Ser Leu Ile Asp Asn Cys Pro Tyr Glu Glu Asn Gln Tyr 
                405                 410                 415     


Met Asp Arg Glu Thr Gly Glu Val Lys Gln Ala Pro Ile Lys Cys Ile 
            420                 425                 430         


Ala Lys Ser His Pro Leu Phe Gln Glu Phe Arg Leu Trp Gln Phe Ile 
        435                 440                 445             


Ser Asn Ile Arg Ile Tyr Gln Arg Glu Arg Val Leu Asp Asp Gly Lys 
    450                 455                 460                 


Leu Glu Thr Asp Val Asp Val Thr Pro Asp Phe Leu Lys Thr Glu Asp 
465                 470                 475                 480 


Asp Tyr Thr Thr Leu Phe Glu Trp Phe Asn Asp Arg Lys Glu Val Asp 
                485                 490                 495     


Gln Lys Ala Phe Leu Lys Asn Pro Gln Phe Gly Leu Lys Lys Thr Phe 
            500                 505                 510         


Thr Glu Tyr Arg Trp Asn Tyr Val Glu Asp Lys Ser Tyr Pro Cys Asn 
        515                 520                 525             


Glu Thr Arg Asn Ala Ile Leu Asn Gly Leu Gln Lys Ala Gly Val Ser 
    530                 535                 540                 


Ala Asp Phe Leu Ser Arg Glu Val Glu Glu Ala Leu Trp His Ile Leu 
545                 550                 555                 560 


Tyr Ser Val Glu Asp Lys Ile Glu Ile Glu Ser Ala Leu Arg Lys Phe 
                565                 570                 575     


Ala Ser Lys His Asp Leu Asp Asp Arg Phe Ala Asp Val Phe Lys Lys 
            580                 585                 590         


Leu Pro Pro Phe Lys Lys Glu Tyr Gly Ala Tyr Ser Ala Lys Ala Ile 
        595                 600                 605             


Lys Lys Leu Leu Pro Leu Met Arg Ile Gly Lys Tyr Trp Glu Leu Ser 
    610                 615                 620                 


Asn Ile Asp Asp Lys Thr Lys Glu Arg Ile Asp Lys Ile Ile Thr Gly 
625                 630                 635                 640 


Glu Trp Asp Glu Asn Ile His Asp Arg Val Arg Glu Lys Ala Ile Lys 
                645                 650                 655     


Leu Ser Asp Ile Thr Asp Phe Lys Gly Leu Pro Leu Trp Leu Ser Cys 
            660                 665                 670         


Tyr Val Val Tyr Asn Arg His Ser Glu Ala Arg Ala Ile Ala Lys Trp 
        675                 680                 685             


Glu Ser Pro Glu Asp Ile Asp Ser Tyr Leu Arg Leu Phe Arg Gln His 
    690                 695                 700                 


Ser Leu Arg Asn Pro Ile Val Glu Gln Val Ile Thr Glu Thr Leu Arg 
705                 710                 715                 720 


Thr Val Arg Asp Ile Trp Lys Arg Val Gly Gln Ile Asp Glu Ile His 
                725                 730                 735     


Val Glu Leu Gly Arg Glu Ile Lys Asn Pro Ala Asp Lys Arg Ala Lys 
            740                 745                 750         


Met Thr Ala Gln Ile Val Glu Asn Glu Asn Thr Asn Leu Arg Ile Lys 
        755                 760                 765             


Ala Leu Leu Ala Glu Phe Ile Asn Ser Glu Tyr Glu Ile Glu Asn Val 
    770                 775                 780                 


Arg Pro Tyr Ser Ser Asn Gln Gln Glu Lys Leu Lys Ile Tyr Glu Asp 
785                 790                 795                 800 


Thr Val Leu Asn Gly Val Lys Glu Ile Pro Glu Asp Ile Asn Thr Ile 
                805                 810                 815     


Leu Lys Lys Phe Arg Glu Ser Asp Leu Lys Lys Arg Pro Thr Lys Ser 
            820                 825                 830         


Asp Phe Leu His Tyr Lys Leu Trp Leu Glu Gln Lys Tyr Cys Ser Pro 
        835                 840                 845             


Tyr Thr Gly Arg Ile Ile Pro Leu Gly Lys Leu Phe Thr Ser Ala Tyr 
    850                 855                 860                 


Glu Ile Glu His Ile Ile Pro Gln Ala His Tyr Phe Asp Asp Ser Phe 
865                 870                 875                 880 


Ser Asn Lys Val Ile Cys Glu Ala Glu Val Asn Gly Leu Lys Asp Lys 
                885                 890                 895     


Lys Leu Gly Tyr Glu Phe Ile Lys His Asn Pro Gly Lys Met Val Glu 
            900                 905                 910         


Ile Gly Phe Gly Lys Pro Pro Val Arg Ile Phe Ser Val Glu Glu Tyr 
        915                 920                 925             


Glu Arg Phe Val Lys Glu Asn Tyr Ser Gly Ile Lys Asn Lys Met Asn 
    930                 935                 940                 


Lys Leu Leu Met Asp Asp Ile Pro Glu Thr Phe Ile Glu Arg Gln Leu 
945                 950                 955                 960 


Asn Asp Ser Arg Tyr Ile Ser Lys Val Val Lys Ser Leu Leu Ser Asn 
                965                 970                 975     


Ile Val Arg Glu Lys Asp Ser Asn Gly Glu Tyr Glu Pro Glu Ala Ile 
            980                 985                 990         


Ser Lys Asn Val Ile Val Cys Thr  Gly Ser Val Thr Asp  Arg Leu Lys 
        995                 1000                 1005             


Arg Asp  Trp Gly Val Asn Asp  Val Trp Asn Ser Ile  Ile Tyr Pro 
    1010                 1015                 1020             


Arg Phe  Glu Arg Leu Asn Glu  Leu Thr Gly Ser Gln  Gln Phe Gly 
    1025                 1030                 1035             


Cys Trp  Glu Asn Lys Glu Gly  Lys Arg Val Phe Gln  Thr Ala Val 
    1040                 1045                 1050             


Pro Leu  Glu Met Gln Lys Gly  Phe Ser Lys Lys Arg  Ile Asp His 
    1055                 1060                 1065             


Arg His  His Ala Met Asp Ala  Ile Val Ile Ala Cys  Ala Thr Arg 
    1070                 1075                 1080             


Asn His  Ile Asn Tyr Leu Ser  Asn Glu Ser Ala Ser  Lys Lys Ala 
    1085                 1090                 1095             


Lys Ile  Ser Arg Thr Asp Leu  Gln Arg Leu Leu Cys  Thr Lys Cys 
    1100                 1105                 1110             


Arg Thr  Asp Asp Asn Gly Asn  Tyr Lys Trp Ile Val  Lys Lys Pro 
    1115                 1120                 1125             


Trp Pro  Ala Phe Thr Gln Asp  Ile Arg Lys Ala Leu  Glu Asn Ile 
    1130                 1135                 1140             


Thr Val  Ser Phe Lys Gln Asn  Leu Arg Val Ile Asn  Lys Thr Thr 
    1145                 1150                 1155             


Asn Tyr  Tyr Val His Phe Asp  Glu Ser Gly Lys Lys  Val Leu Glu 
    1160                 1165                 1170             


Lys Gln  Ile Asn Gly Asp Ser  Trp Ala Ile Arg Lys  Pro Met His 
    1175                 1180                 1185             


Lys Asp  Thr Val Phe Gly Lys  Val Asn Leu Gln Lys  Val Lys Glu 
    1190                 1195                 1200             


Val Arg  Leu Ser Leu Ala Leu  Asp Thr Pro Lys Met  Ile Val Asp 
    1205                 1210                 1215             


Lys Lys  Leu Lys Glu Lys Val  Leu Gln Leu Tyr Ser  Tyr Lys Tyr 
    1220                 1225                 1230             


Asp Lys  Lys Arg Ile Asp Lys  Tyr Phe Lys Glu Asn  Ala Ser Leu 
    1235                 1240                 1245             


Trp Lys  Asp Leu Asn Leu Ser  Lys Val Ala Val Tyr  Tyr Phe Thr 
    1250                 1255                 1260             


Asn Asp  Ser Thr Glu Pro Leu  Val Ala Val Arg Lys  Pro Leu Asp 
    1265                 1270                 1275             


Thr Ser  Phe Asn Ala Lys Lys  Ile Lys Glu Ser Val  Thr Asp Thr 
    1280                 1285                 1290             


Gly Ile  Gln Lys Ile Leu Leu  Asn His Leu Ser Asn  Asn Gln Asp 
    1295                 1300                 1305             


Asp Pro  Asn Leu Ala Phe Ser  Pro Asp Gly Ile Asp  Lys Met Asn 
    1310                 1315                 1320             


Lys Asn  Leu Thr Ala Leu Asn  Asp Gly Lys Tyr His  Gln Pro Ile 
    1325                 1330                 1335             


Tyr Lys  Val Arg Val Cys Glu  Pro Gln Gly Asn Lys  Phe Ser Val 
    1340                 1345                 1350             


Gly Thr  Ser Gly Asn Lys Thr  Ser Lys Tyr Val Glu  Ala Ala Lys 
    1355                 1360                 1365             


Gly Thr  Asn Leu Phe Phe Ala  Val Tyr Gln Thr Glu  Asp Gly Lys 
    1370                 1375                 1380             


Arg Ser  Tyr Glu Thr Ile Pro  Leu Asn Val Val Ile  Glu Arg Glu 
    1385                 1390                 1395             


Lys Leu  Gly Trp Thr Pro Val  Pro Glu Asn Asn Asn  Asn Gly Asp 
    1400                 1405                 1410             


Lys Leu  Leu Phe Trp Leu Ser  Pro Asn Asp Leu Val  Tyr Val Pro 
    1415                 1420                 1425             


Thr Ala  Asp Glu Leu Asn Asn  Gly Met Arg Leu Asp  Asn Met Asp 
    1430                 1435                 1440             


Lys Gly  Arg Ile Tyr Lys Met  Ile Ser Cys Ser Gly  Pro Gln Cys 
    1445                 1450                 1455             


Phe Phe  Ile Pro Gln Asn Val  Ser Asn Ala Ile Ile  Pro Val Ile 
    1460                 1465                 1470             


Glu Leu  Gly Ala Asn Asn Lys  Ala Glu Lys Ser Trp  Asn Asn Glu 
    1475                 1480                 1485             


Met Ile  Lys Val Val Cys Val  Pro Ile Arg Val Asp  Arg Leu Gly 
    1490                 1495                 1500             


Cys Ile  Thr Gln Ile Asn Asn  Gln Lys 
    1505                 1510         


<210> 82
<211> 1436
<212> PRT
<213> Bacteroides sp.


<220>
<223> Bacteroides sp. 2_1_16

<400> 82
Met Lys Arg Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Asn Glu Ala Glu Asn Lys Asp Glu Arg Ser Ser Ile Val 
            20                  25                  30          


Lys Leu Gly Val Arg Val Asn Pro Leu Thr Val Asp Glu Leu Thr Asn 
        35                  40                  45              


Phe Glu Lys Gly Lys Ser Ile Thr Thr Asn Ala Asp Arg Thr Leu Lys 
    50                  55                  60                  


Arg Gly Met Arg Arg Asn Leu Gln Arg Tyr Lys Leu Arg Arg Glu Thr 
65                  70                  75                  80  


Leu Thr Glu Val Leu Lys Glu His Lys Leu Ile Thr Glu Asp Thr Ile 
                85                  90                  95      


Leu Ser Glu Asn Gly Asn Arg Thr Thr Phe Glu Thr Tyr Arg Leu Arg 
            100                 105                 110         


Ala Lys Ala Val Thr Glu Glu Ile Ser Leu Glu Glu Phe Ala Arg Val 
        115                 120                 125             


Leu Leu Met Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala 
    130                 135                 140                 


Lys Gly Val Glu Glu Gly Thr Leu Ile Asp Gly Met Asp Ile Ala Arg 
145                 150                 155                 160 


Glu Leu Tyr Asn Asn Asn Leu Thr Pro Gly Glu Leu Cys Leu Gln Leu 
                165                 170                 175     


Leu Asp Ala Gly Lys Lys Phe Leu Pro Asp Phe Tyr Arg Ser Asp Leu 
            180                 185                 190         


Gln Asn Glu Leu Asp Arg Ile Trp Glu Lys Gln Lys Glu Tyr Tyr Pro 
        195                 200                 205             


Glu Ile Leu Thr Asp Val Leu Lys Glu Glu Leu Arg Gly Lys Lys Arg 
    210                 215                 220                 


Asp Ala Val Trp Ala Ile Cys Ala Lys Tyr Phe Val Trp Lys Glu Thr 
225                 230                 235                 240 


Tyr Thr Glu Trp Asn Lys Glu Lys Gly Lys Thr Glu Gln Gln Glu Arg 
                245                 250                 255     


Glu His Lys Leu Glu Gly Ile Tyr Ser Lys Arg Lys Arg Asp Glu Ala 
            260                 265                 270         


Lys Arg Glu Asn Leu Gln Trp Arg Val Asn Gly Leu Lys Glu Lys Leu 
        275                 280                 285             


Ser Leu Glu Gln Leu Val Ile Val Phe Gln Glu Met Asn Thr Gln Ile 
    290                 295                 300                 


Asn Asn Ser Ser Gly Tyr Leu Gly Ala Ile Ser Asp Arg Ser Lys Glu 
305                 310                 315                 320 


Leu Tyr Phe Asn Lys Gln Thr Val Gly Gln Tyr Gln Met Glu Met Leu 
                325                 330                 335     


Asp Lys Asn Pro Asn Ala Ser Leu Arg Asn Met Val Phe Tyr Arg Gln 
            340                 345                 350         


Asp Tyr Leu Asp Glu Phe Asn Met Leu Trp Glu Lys Gln Ala Val Tyr 
        355                 360                 365             


His Lys Glu Leu Thr Glu Glu Leu Lys Lys Glu Ile Arg Asp Ile Ile 
    370                 375                 380                 


Ile Phe Tyr Gln Arg Arg Leu Lys Ser Gln Lys Gly Leu Ile Gly Phe 
385                 390                 395                 400 


Cys Glu Phe Glu Ser Arg Gln Ile Glu Val Asp Ile Asp Gly Lys Lys 
                405                 410                 415     


Lys Ile Lys Thr Val Gly Asn Arg Val Ile Ser Arg Ser Ser Pro Leu 
            420                 425                 430         


Phe Gln Glu Phe Lys Ile Trp Gln Ile Leu Asn Asn Ile Glu Val Thr 
        435                 440                 445             


Val Val Gly Lys Lys Arg Lys Arg Arg Lys Leu Lys Glu Asn Tyr Ser 
    450                 455                 460                 


Ala Ile Phe Glu Glu Leu Asn Asp Ala Glu Gln Leu Glu Leu Asn Gly 
465                 470                 475                 480 


Ser Arg Arg Leu Cys Gln Glu Glu Lys Glu Leu Leu Ala Gln Glu Leu 
                485                 490                 495     


Phe Val Arg Asp Lys Met Thr Lys Ser Glu Val Leu Lys Leu Leu Phe 
            500                 505                 510         


Asp Asn Pro Gln Glu Leu Asp Leu Asn Phe Lys Thr Ile Asp Gly Asn 
        515                 520                 525             


Lys Thr Gly Tyr Ala Leu Phe Gln Ala Tyr Ser Lys Met Ile Glu Met 
    530                 535                 540                 


Ser Gly His Glu Pro Val Asp Phe Lys Lys Pro Val Glu Lys Val Val 
545                 550                 555                 560 


Glu Tyr Ile Lys Ala Val Phe Asp Leu Leu Asn Trp Asn Thr Asp Ile 
                565                 570                 575     


Leu Gly Phe Asn Ser Asn Glu Glu Leu Asp Asn Gln Ser Tyr Tyr Lys 
            580                 585                 590         


Leu Trp His Leu Leu Tyr Ser Phe Glu Gly Asp Asn Thr Pro Thr Gly 
        595                 600                 605             


Asn Gly Arg Leu Ile Gln Lys Met Thr Glu Leu Tyr Gly Phe Glu Lys 
    610                 615                 620                 


Glu Tyr Ala Thr Ile Leu Ala Asn Val Ser Phe Gln Asp Asp Tyr Gly 
625                 630                 635                 640 


Ser Leu Ser Ala Lys Ala Ile His Lys Ile Leu Pro His Leu Lys Glu 
                645                 650                 655     


Gly Asn Arg Tyr Asp Val Ala Cys Val Tyr Ala Gly Tyr Arg His Ser 
            660                 665                 670         


Glu Ser Ser Leu Thr Arg Glu Glu Ile Ala Asn Lys Val Leu Lys Asp 
        675                 680                 685             


Arg Leu Met Leu Leu Pro Lys Asn Ser Leu His Asn Pro Val Val Glu 
    690                 695                 700                 


Lys Ile Leu Asn Gln Met Val Asn Val Ile Asn Val Ile Ile Asp Ile 
705                 710                 715                 720 


Tyr Gly Lys Pro Asp Glu Ile Arg Val Glu Leu Ala Arg Glu Leu Lys 
                725                 730                 735     


Lys Asn Ala Lys Glu Arg Glu Glu Leu Thr Lys Ser Ile Ala Gln Thr 
            740                 745                 750         


Thr Lys Ala Asn Glu Glu Tyr Lys Thr Leu Leu Gln Thr Glu Phe Gly 
        755                 760                 765             


Leu Thr Asn Val Ser Arg Thr Asp Ile Leu Arg Tyr Lys Leu Tyr Lys 
    770                 775                 780                 


Glu Leu Glu Ser Cys Gly Tyr Lys Thr Leu Tyr Ser Asn Thr Tyr Ile 
785                 790                 795                 800 


Ser Arg Glu Lys Leu Phe Ser Lys Glu Phe Asp Ile Glu His Ile Ile 
                805                 810                 815     


Pro Gln Ala Arg Leu Phe Asp Asp Ser Phe Ser Asn Lys Thr Leu Glu 
            820                 825                 830         


Ala Arg Ser Val Asn Ile Glu Lys Gly Asn Lys Thr Ala Tyr Asp Phe 
        835                 840                 845             


Val Lys Glu Lys Phe Gly Glu Ser Gly Ala Asp Asn Ser Leu Glu His 
    850                 855                 860                 


Tyr Leu Asn Asn Ile Glu Asp Leu Phe Lys Ser Gly Lys Ile Ser Lys 
865                 870                 875                 880 


Thr Lys Tyr Asn Lys Leu Lys Met Ala Glu Gln Asp Ile Pro Asp Gly 
                885                 890                 895     


Phe Ile Glu Arg Asp Leu Arg Asn Thr Gln Tyr Ile Ala Lys Lys Ala 
            900                 905                 910         


Leu Ser Met Leu Asn Glu Ile Ser His Arg Val Val Ala Thr Ser Gly 
        915                 920                 925             


Ser Val Thr Asp Lys Leu Arg Glu Asp Trp Gln Leu Ile Asp Val Met 
    930                 935                 940                 


Lys Glu Leu Asn Trp Glu Lys Tyr Lys Ala Leu Gly Leu Val Glu Tyr 
945                 950                 955                 960 


Phe Glu Asp Arg Asp Gly Arg Gln Ile Gly Arg Ile Lys Asp Trp Thr 
                965                 970                 975     


Lys Arg Asn Asp His Arg His His Ala Met Asp Ala Leu Thr Val Ala 
            980                 985                 990         


Phe Thr Lys Asp Val Phe Ile Gln  Tyr Phe Asn Asn Lys  Asn Ala Ser 
        995                 1000                 1005             


Leu Asp  Pro Asn Ala Asn Glu  His Ala Ile Lys Asn  Lys Tyr Phe 
    1010                 1015                 1020             


Gln Asn  Gly Arg Ala Ile Ala  Pro Met Pro Leu Arg  Glu Phe Arg 
    1025                 1030                 1035             


Ala Glu  Ala Lys Lys His Leu  Glu Asn Thr Leu Ile  Ser Ile Lys 
    1040                 1045                 1050             


Ala Lys  Asn Lys Val Ile Thr  Gly Asn Ile Asn Lys  Thr Arg Lys 
    1055                 1060                 1065             


Lys Gly  Gly Val Asn Lys Asn  Met Gln Gln Thr Pro  Arg Gly Gln 
    1070                 1075                 1080             


Leu His  Leu Glu Thr Ile Tyr  Gly Ser Gly Lys Gln  Tyr Leu Thr 
    1085                 1090                 1095             


Lys Glu  Glu Lys Val Asn Ala  Ser Phe Asp Met Arg  Lys Ile Glu 
    1100                 1105                 1110             


Thr Val  Ser Lys Ser Ala Tyr  Arg Asp Ala Leu Leu  Lys Arg Leu 
    1115                 1120                 1125             


Tyr Glu  Asn Asp Asn Asp Pro  Lys Lys Ala Phe Ala  Gly Lys Asn 
    1130                 1135                 1140             


Ser Leu  Asp Lys Gln Pro Ile  Trp Leu Asp Lys Glu  Gln Met Arg 
    1145                 1150                 1155             


Lys Val  Pro Glu Lys Val Lys  Ile Val Thr Leu Glu  Ala Ile Tyr 
    1160                 1165                 1170             


Thr Ile  Arg Lys Glu Ile Ser  Pro Asp Leu Lys Val  Asp Lys Val 
    1175                 1180                 1185             


Ile Asp  Val Gly Val Arg Lys  Ile Leu Ile Asp Arg  Leu Asn Glu 
    1190                 1195                 1200             


Tyr Gly  Asn Asp Ala Lys Lys  Ala Phe Ser Asn Leu  Asp Lys Asn 
    1205                 1210                 1215             


Pro Ile  Trp Leu Asn Lys Glu  Lys Gly Ile Ser Ile  Lys Arg Val 
    1220                 1225                 1230             


Thr Ile  Ser Gly Ile Ser Asn  Ala Gln Ser Leu His  Val Lys Lys 
    1235                 1240                 1245             


Asp Lys  Asp Gly Lys Pro Ile  Leu Asp Glu Asn Gly  Arg Asn Ile 
    1250                 1255                 1260             


Pro Val  Asp Phe Val Asn Thr  Gly Asn Asn His His  Val Ala Val 
    1265                 1270                 1275             


Tyr Tyr  Arg Pro Val Ile Asp  Lys Arg Gly Gln Leu  Val Val Asp 
    1280                 1285                 1290             


Glu Ala  Gly Asn Pro Lys Tyr  Glu Leu Glu Glu Val  Val Val Ser 
    1295                 1300                 1305             


Phe Phe  Glu Ala Val Thr Arg  Ala Asn Leu Gly Leu  Pro Ile Ile 
    1310                 1315                 1320             


Asp Lys  Asp Tyr Lys Thr Thr  Glu Gly Trp Gln Phe  Leu Phe Ser 
    1325                 1330                 1335             


Met Lys  Gln Asn Glu Tyr Phe  Val Phe Pro Asn Glu  Lys Ile Gly 
    1340                 1345                 1350             


Phe Asn  Pro Lys Glu Ile Asp  Leu Leu Asp Val Glu  Asn Tyr Gly 
    1355                 1360                 1365             


Leu Ile  Ser Pro Asn Leu Phe  Arg Val Gln Lys Phe  Ser Leu Lys 
    1370                 1375                 1380             


Asn Tyr  Val Phe Arg His His  Leu Glu Thr Thr Ile  Lys Asp Thr 
    1385                 1390                 1395             


Ser Ser  Ile Leu Arg Gly Ile  Thr Trp Ile Asp Phe  Arg Ser Ser 
    1400                 1405                 1410             


Lys Gly  Leu Asp Thr Ile Val  Lys Val Arg Val Asn  His Ile Gly 
    1415                 1420                 1425             


Gln Ile  Val Ser Val Gly Glu  Tyr 
    1430                 1435     


<210> 83
<211> 1517
<212> PRT
<213> Bacteroides sp.


<220>
<223> Bacteroides sp. 20_3

<400> 83
Met Lys Lys Ile Val Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Ile Asn Ala Tyr Ile Asn Lys Glu His Leu Tyr Gly Ile Glu 
            20                  25                  30          


Ala Cys Gly Ser Arg Ile Ile Pro Met Asp Ala Ala Ile Leu Gly Asn 
        35                  40                  45              


Phe Asp Lys Gly Asn Ser Ile Ser Gln Thr Ala Asp Arg Thr Ser Tyr 
    50                  55                  60                  


Arg Gly Ile Arg Arg Leu Arg Glu Arg His Leu Leu Arg Arg Glu Arg 
65                  70                  75                  80  


Leu His Arg Ile Leu Asp Leu Leu Gly Phe Leu Pro Lys His Tyr Ser 
                85                  90                  95      


Asp Ser Leu Asn Arg Tyr Gly Lys Phe Leu Asn Asp Ile Glu Cys Lys 
            100                 105                 110         


Leu Pro Trp Val Lys Asp Glu Thr Gly Ser Tyr Lys Phe Ile Phe Gln 
        115                 120                 125             


Glu Ser Phe Lys Glu Met Leu Ala Asn Phe Thr Glu His His Pro Ile 
    130                 135                 140                 


Leu Ile Ala Asn Asn Lys Lys Val Pro Tyr Asp Trp Thr Ile Tyr Tyr 
145                 150                 155                 160 


Leu Arg Lys Lys Ala Leu Thr Gln Lys Ile Ser Lys Glu Glu Leu Ala 
                165                 170                 175     


Trp Ile Leu Leu Asn Phe Asn Gln Lys Arg Gly Tyr Tyr Gln Leu Arg 
            180                 185                 190         


Gly Glu Glu Glu Glu Thr Pro Asn Lys Leu Val Glu Tyr Tyr Ser Leu 
        195                 200                 205             


Lys Val Glu Lys Val Glu Asp Ser Gly Glu Arg Lys Gly Lys Asp Thr 
    210                 215                 220                 


Trp Tyr Asn Val His Leu Glu Asn Gly Met Ile Tyr Arg Arg Thr Ser 
225                 230                 235                 240 


Asn Ile Pro Leu Asp Trp Glu Gly Lys Thr Lys Glu Phe Ile Val Thr 
                245                 250                 255     


Thr Asp Leu Glu Ala Asp Gly Ser Pro Lys Lys Asp Lys Glu Gly Asn 
            260                 265                 270         


Ile Lys Arg Ser Phe Arg Ala Pro Lys Asp Asp Asp Trp Thr Leu Ile 
        275                 280                 285             


Lys Lys Lys Thr Glu Ala Asp Ile Asp Lys Ile Lys Met Thr Val Gly 
    290                 295                 300                 


Ala Tyr Ile Tyr Asp Thr Leu Leu Gln Lys Pro Asp Gln Lys Ile Arg 
305                 310                 315                 320 


Gly Lys Leu Val Arg Thr Ile Glu Arg Lys Tyr Tyr Lys Asn Glu Leu 
                325                 330                 335     


Tyr Gln Ile Leu Lys Thr Gln Ser Glu Phe His Glu Glu Leu Arg Asp 
            340                 345                 350         


Lys Gln Leu Tyr Ile Ala Cys Leu Asn Glu Leu Tyr Pro Asn Asn Glu 
        355                 360                 365             


Pro Arg Arg Asn Ser Ile Ser Thr Arg Asp Phe Cys His Leu Phe Ile 
    370                 375                 380                 


Glu Asp Ile Ile Phe Tyr Gln Arg Pro Leu Lys Ser Lys Lys Ser Leu 
385                 390                 395                 400 


Ile Asp Asn Cys Pro Tyr Glu Glu Asn Arg Tyr Ile Asp Lys Glu Ser 
                405                 410                 415     


Gly Glu Ile Lys His Ala Ser Ile Lys Cys Ile Ala Lys Ser His Pro 
            420                 425                 430         


Leu Tyr Gln Glu Phe Arg Leu Trp Gln Phe Ile Val Asn Leu Arg Ile 
        435                 440                 445             


Tyr Arg Lys Glu Thr Asp Val Asp Val Thr Gln Glu Leu Leu Pro Thr 
    450                 455                 460                 


Glu Ala Asp Tyr Val Thr Leu Phe Glu Trp Leu Asn Glu Lys Lys Glu 
465                 470                 475                 480 


Ile Asp Gln Lys Ala Phe Phe Lys Tyr Pro Pro Phe Gly Phe Lys Lys 
                485                 490                 495     


Thr Thr Ser Asn Tyr Arg Trp Asn Tyr Val Glu Asp Lys Pro Tyr Pro 
            500                 505                 510         


Cys Asn Glu Thr His Ala Gln Ile Ile Ala Arg Leu Gly Lys Ala His 
        515                 520                 525             


Ile Pro Lys Ala Phe Leu Ser Lys Glu Lys Glu Glu Thr Leu Trp His 
    530                 535                 540                 


Ile Leu Tyr Ser Ile Glu Asp Lys Gln Glu Ile Glu Lys Ala Leu His 
545                 550                 555                 560 


Ser Phe Ala Asn Lys Asn Asn Leu Ser Glu Glu Phe Ile Glu Gln Phe 
                565                 570                 575     


Lys Asn Phe Pro Pro Phe Lys Lys Glu Tyr Gly Ser Tyr Ser Ala Lys 
            580                 585                 590         


Ala Ile Lys Lys Leu Leu Pro Leu Met Arg Met Gly Lys Tyr Trp Ser 
        595                 600                 605             


Ile Glu Asn Ile Asp Asn Gly Thr Arg Ile Arg Ile Asn Lys Ile Ile 
    610                 615                 620                 


Asp Gly Glu Tyr Asp Glu Asn Ile Arg Glu Arg Val Arg Gln Lys Ala 
625                 630                 635                 640 


Ile Asn Leu Thr Asp Ile Thr His Phe Arg Ala Leu Pro Leu Trp Leu 
                645                 650                 655     


Ala Cys Tyr Leu Val Tyr Asp Arg His Ser Glu Val Lys Asp Ile Val 
            660                 665                 670         


Lys Trp Lys Thr Pro Lys Asp Ile Asp Leu Tyr Leu Lys Ser Phe Lys 
        675                 680                 685             


Gln His Ser Leu Arg Asn Pro Ile Val Glu Gln Val Ile Thr Glu Thr 
    690                 695                 700                 


Leu Arg Thr Val Arg Asp Ile Trp Gln Gln Val Gly His Ile Asp Glu 
705                 710                 715                 720 


Ile His Ile Glu Leu Gly Arg Glu Met Lys Asn Pro Ala Asp Lys Arg 
                725                 730                 735     


Ala Arg Met Ser Gln Gln Met Ile Lys Asn Glu Asn Thr Asn Leu Arg 
            740                 745                 750         


Ile Lys Ala Leu Leu Thr Glu Phe Leu Asn Pro Glu Phe Gly Ile Glu 
        755                 760                 765             


Asn Val Arg Pro Tyr Ser Pro Ser Gln Gln Asp Leu Leu Arg Ile Tyr 
    770                 775                 780                 


Glu Glu Gly Val Leu Asn Ser Ile Leu Glu Leu Pro Glu Asp Ile Gly 
785                 790                 795                 800 


Ile Ile Leu Gly Lys Phe Asn Gln Thr Asp Thr Leu Lys Arg Pro Thr 
                805                 810                 815     


Arg Ser Glu Ile Leu Arg Tyr Lys Leu Trp Leu Glu Gln Lys Tyr Arg 
            820                 825                 830         


Ser Pro Tyr Thr Gly Glu Met Ile Pro Leu Ser Lys Leu Phe Thr Pro 
        835                 840                 845             


Ala Tyr Glu Ile Glu His Ile Ile Pro Gln Ser Arg Tyr Phe Asp Asp 
    850                 855                 860                 


Ser Leu Ser Asn Lys Val Ile Cys Glu Ser Glu Ile Asn Lys Leu Lys 
865                 870                 875                 880 


Asp Arg Ser Leu Gly Tyr Glu Phe Ile Lys Asn His His Gly Glu Lys 
                885                 890                 895     


Val Glu Leu Ala Phe Asp Lys Pro Val Glu Val Leu Ser Val Glu Ala 
            900                 905                 910         


Tyr Glu Lys Leu Val His Glu Ser Tyr Ser His Asn Arg Ser Lys Met 
        915                 920                 925             


Lys Lys Leu Leu Met Glu Asp Ile Pro Asp Gln Phe Ile Glu Arg Gln 
    930                 935                 940                 


Leu Asn Asp Ser Arg Tyr Ile Ser Lys Val Val Lys Ser Leu Leu Ser 
945                 950                 955                 960 


Asn Ile Val Arg Glu Glu Asn Glu Gln Glu Ala Ile Ser Lys Asn Val 
                965                 970                 975     


Ile Pro Cys Thr Gly Gly Ile Thr Asp Arg Leu Lys Lys Asp Trp Gly 
            980                 985                 990         


Ile Asn Asp Val Trp Asn Lys Ile  Val Leu Pro Arg Phe  Ile Arg Leu 
        995                 1000                 1005             


Asn Glu  Leu Thr Glu Ser Thr  Arg Phe Thr Ser Ile  Asn Thr Asn 
    1010                 1015                 1020             


Asn Thr  Met Ile Pro Ser Met  Pro Leu Glu Leu Gln  Lys Gly Phe 
    1025                 1030                 1035             


Asn Lys  Lys Arg Ile Asp His  Arg His His Ala Met  Asp Ala Ile 
    1040                 1045                 1050             


Ile Ile  Ala Cys Ala Asn Arg  Asn Ile Val Asn Tyr  Leu Asn Asn 
    1055                 1060                 1065             


Val Ser  Ala Ser Lys Asn Thr  Lys Ile Thr Arg Arg  Asp Leu Gln 
    1070                 1075                 1080             


Thr Leu  Leu Cys His Lys Asp  Lys Thr Asp Asn Asn  Gly Asn Tyr 
    1085                 1090                 1095             


Lys Trp  Val Ile Asp Lys Pro  Trp Glu Thr Phe Thr  Gln Asp Thr 
    1100                 1105                 1110             


Leu Thr  Ala Leu Gln Lys Ile  Thr Val Ser Phe Lys  Gln Asn Leu 
    1115                 1120                 1125             


Arg Val  Ile Asn Lys Thr Thr  Asn His Tyr Gln His  Tyr Glu Asn 
    1130                 1135                 1140             


Gly Lys  Lys Ile Val Ser Asn  Gln Ser Lys Gly Asp  Ser Trp Ala 
    1145                 1150                 1155             


Ile Arg  Lys Ser Met His Lys  Glu Thr Val His Gly  Glu Val Asn 
    1160                 1165                 1170             


Leu Arg  Met Ile Lys Thr Val  Ser Phe Asn Glu Ala  Leu Lys Lys 
    1175                 1180                 1185             


Pro Gln  Ala Ile Val Glu Met  Asp Leu Lys Lys Lys  Ile Leu Ala 
    1190                 1195                 1200             


Met Leu  Glu Leu Gly Tyr Asp  Thr Lys Arg Ile Lys  Asn Tyr Phe 
    1205                 1210                 1215             


Glu Glu  Asn Lys Asp Thr Trp  Gln Asp Ile Asn Pro  Ser Lys Ile 
    1220                 1225                 1230             


Lys Val  Tyr Tyr Phe Thr Lys  Glu Thr Lys Asp Arg  Tyr Phe Ala 
    1235                 1240                 1245             


Val Arg  Lys Pro Ile Asp Thr  Ser Phe Asp Lys Lys  Lys Ile Lys 
    1250                 1255                 1260             


Glu Ser  Ile Thr Asp Thr Gly  Ile Gln Gln Ile Met  Leu Arg His 
    1265                 1270                 1275             


Leu Glu  Thr Lys Asp Asn Asp  Pro Thr Leu Ala Phe  Ser Pro Asp 
    1280                 1285                 1290             


Gly Ile  Asp Glu Met Asn Arg  Asn Ile Leu Ile Leu  Asn Lys Gly 
    1295                 1300                 1305             


Lys Lys  His Gln Pro Ile Tyr  Lys Val Arg Val Tyr  Glu Lys Ala 
    1310                 1315                 1320             


Glu Lys  Phe Thr Val Gly Gln  Lys Gly Asn Lys Arg  Thr Lys Phe 
    1325                 1330                 1335             


Val Glu  Ala Ala Lys Gly Thr  Asn Leu Phe Phe Ala  Ile Tyr Glu 
    1340                 1345                 1350             


Thr Glu  Glu Ile Asp Lys Asp  Thr Lys Lys Val Ile  Arg Lys Arg 
    1355                 1360                 1365             


Ser Tyr  Ser Thr Ile Pro Leu  Asn Val Val Ile Glu  Arg Gln Lys 
    1370                 1375                 1380             


Gln Gly  Leu Ser Ser Ala Pro  Glu Asp Glu Asn Gly  Asn Leu Pro 
    1385                 1390                 1395             


Lys Tyr  Ile Leu Ser Pro Asn  Asp Leu Val Tyr Val  Pro Thr Gln 
    1400                 1405                 1410             


Glu Glu  Ile Asn Lys Gly Glu  Val Val Met Pro Ile  Asp Arg Asp 
    1415                 1420                 1425             


Arg Ile  Tyr Lys Met Val Asp  Ser Ser Gly Ile Thr  Ala Asn Phe 
    1430                 1435                 1440             


Ile Pro  Ala Ser Thr Ala Asn  Leu Ile Phe Ala Leu  Pro Lys Ala 
    1445                 1450                 1455             


Thr Ala  Glu Ile Tyr Cys Asn  Gly Glu Asn Cys Ile  Gln Asn Glu 
    1460                 1465                 1470             


Tyr Gly  Ile Gly Ser Pro Gln  Ser Lys Asn Gln Lys  Ala Ile Thr 
    1475                 1480                 1485             


Gly Glu  Met Val Lys Glu Ile  Cys Phe Pro Ile Lys  Val Asp Arg 
    1490                 1495                 1500             


Leu Gly  Asn Ile Ile Gln Val  Gly Ser Cys Ile Leu  Thr Asn 
    1505                 1510                 1515         


<210> 84
<211> 1424
<212> PRT
<213> Bacteroides sp.


<220>
<223> Bacteroides sp. 3_1_19

<400> 84
Met Lys Arg Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Asn Glu Ala Glu Thr Asp Glu Glu Val Ser Ser Ile Ile 
            20                  25                  30          


Arg Leu Gly Val Arg Val Asn Pro Leu Thr Val Asp Glu Thr Gln Asn 
        35                  40                  45              


Phe Glu Lys Gly Lys Ser Ile Thr Thr Asn Ala Glu Arg Thr Leu Lys 
    50                  55                  60                  


Arg Ser Met Arg Arg Asn Leu Gln Arg Tyr Lys Leu Arg Arg Asp Ala 
65                  70                  75                  80  


Leu Val Glu Phe Leu Lys Glu Leu Gly Phe Ile Thr Asp Glu Thr Ile 
                85                  90                  95      


Leu Ser Glu Gln Gly Asn Arg Thr Thr Phe Glu Thr Cys Arg Leu Arg 
            100                 105                 110         


Ala Lys Ala Ala Glu Glu Glu Ile Ser Leu Glu Glu Leu Ser Arg Val 
        115                 120                 125             


Leu Leu Met Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Val 
    130                 135                 140                 


Lys Lys Glu Glu Asp Gly Val Leu Ile Asp Gly Met Glu Ile Ala Lys 
145                 150                 155                 160 


Lys Leu Tyr Glu Glu Asp Leu Thr Pro Gly Gln Leu Cys Ser Gln Leu 
                165                 170                 175     


Leu Glu Ser Gly Lys Lys Val Leu Pro Asp Phe Tyr His Ser Asp Leu 
            180                 185                 190         


Gln Glu Glu Leu Asp Arg Ile Trp Ser Val Gln Lys Gln Phe His Pro 
        195                 200                 205             


Asp Val Phe Cys Asp Ala Ala Lys Glu Glu Ile Lys Gly Lys Asn Arg 
    210                 215                 220                 


Ser Gln Thr Trp Ala Ile Leu Ala Asn Tyr Phe Val Trp Lys Glu Glu 
225                 230                 235                 240 


Val Val Gly Trp Asn Asp Arg Glu Ala Lys Asn Glu Thr Ile Glu Lys 
                245                 250                 255     


Glu Cys Lys Leu Val Gly Leu Lys Arg Thr Thr Lys Gly Tyr Glu Leu 
            260                 265                 270         


Lys Lys Glu Asn Tyr Arg Trp Arg Ala Gln Ala Leu Thr Glu Gln Leu 
        275                 280                 285             


Gly Leu Glu Glu Ile Ala Val Val Leu Gln Glu Ile Asn Gly Gln Ile 
    290                 295                 300                 


Asn Ala Ser Ser Gly Tyr Leu Gly Ala Ile Ser Asp Arg Ser Lys Val 
305                 310                 315                 320 


Leu Tyr Phe Asn His Gln Thr Val Gly Gln Tyr Gln Met Ala Glu Leu 
                325                 330                 335     


Asp Lys Asn Pro His Ala Ser Leu Arg Asn Met Val Phe Tyr Arg Gln 
            340                 345                 350         


Asp Tyr Leu Asp Glu Phe Asp Arg Ile Trp Glu Lys Gln Ala Glu Phe 
        355                 360                 365             


His Lys Glu Leu Thr Ala Glu Leu Lys Lys Glu Ile Arg Asp Met Ile 
    370                 375                 380                 


Ile Phe Tyr Gln Arg Arg Leu Lys Ser Gln Lys Gly Leu Ile Ser Phe 
385                 390                 395                 400 


Cys Glu Phe Glu Arg Leu Glu Ile Val Val Glu Lys Asp Gly Lys Lys 
                405                 410                 415     


Gln Thr Lys Val Ile Gly Cys Lys Val Ile Pro Arg Ser His Pro Leu 
            420                 425                 430         


Phe Gln Glu Phe Lys Val Trp Gln Thr Leu Asn Asp Ile Lys Val Leu 
        435                 440                 445             


Gly Arg Glu Lys Lys Arg Asn Ala Leu Ser Ala Ser Glu Ser Arg Ala 
    450                 455                 460                 


Leu Tyr Pro Glu Glu Lys Glu Ile Leu Ala Arg Glu Leu Ala Ile Lys 
465                 470                 475                 480 


Glu Asn Met Lys Lys Ala Asp Val Leu Lys Leu Leu Phe Glu Asn Pro 
                485                 490                 495     


Gln Glu Leu Asp Leu Asn Phe Lys Gln Ile Asp Gly Asn Arg Thr Gly 
            500                 505                 510         


Phe Ser Leu Phe Ser Ala Tyr Ser Lys Met Ile Glu Lys Tyr Gly Tyr 
        515                 520                 525             


Glu Pro Leu Asp Phe Lys Lys Pro Ala Asp Glu Ile Ile Gly Gln Leu 
    530                 535                 540                 


Arg Thr Ile Phe Thr Asp Leu Gly Trp Asn Thr Asn Leu Phe Thr Ile 
545                 550                 555                 560 


Asp Leu Thr Lys Glu Gly Lys Glu Leu Glu Met Gln Pro Tyr Phe Arg 
                565                 570                 575     


Leu Trp His Leu Leu Tyr Ser Phe Glu Gly Asp Asn Thr Ser Thr Gly 
            580                 585                 590         


Asn Gly Lys Leu Ile Glu Lys Ile Met Gln Leu Cys Gly Val Glu Lys 
        595                 600                 605             


Glu Tyr Ala Val Glu Leu Ala Ser Leu Ser Phe Gln Asp Asp Tyr Gly 
    610                 615                 620                 


Ser Leu Ser Ala Lys Ala Ile Lys Arg Ile Leu Pro Tyr Leu Lys Glu 
625                 630                 635                 640 


Gly Asn Leu Tyr Asp Val Ala Cys Glu Tyr Ala Gly Tyr Arg His Ser 
                645                 650                 655     


Lys Ser Ser Leu Thr Lys Glu Glu Ile Glu Asn Lys Val Leu Lys Gly 
            660                 665                 670         


Lys Leu Glu Val Leu Pro Lys Asn Ser Leu Arg Asn Pro Val Val Glu 
        675                 680                 685             


Lys Ile Leu Ser Gln Met Val Asn Val Ile Asn Thr Ile Ile Asp Thr 
    690                 695                 700                 


Tyr Gly Lys Pro Asp Glu Ile Arg Val Glu Leu Ala Arg Glu Leu Lys 
705                 710                 715                 720 


Lys Ser Ala Lys Glu Arg Glu Glu Leu Thr Lys Ala Ile Ala Lys Ser 
                725                 730                 735     


Thr Arg Glu His Glu Glu Ile Arg Lys Leu Leu Gln Asp Glu Phe Gly 
            740                 745                 750         


Met Met Asn Val Ser Arg Asn Asp Ile Ile Arg Tyr Lys Leu Tyr Glu 
        755                 760                 765             


Glu Leu Lys Asp Asn Gly Tyr Lys Thr Leu Tyr Ser Asn Gln Tyr Ile 
    770                 775                 780                 


Pro Lys Glu Lys Ile Phe Ser Lys Glu Ile Asp Ile Glu His Ile Ile 
785                 790                 795                 800 


Pro Gln Ser Arg Leu Phe Asp Asp Ser Leu Ser Asn Lys Thr Leu Glu 
                805                 810                 815     


Tyr Lys Ala Ile Asn Ile Glu Lys Gly Asn Lys Thr Ala Tyr Asp Phe 
            820                 825                 830         


Val Lys Glu Lys Tyr Gly Glu Glu Gly Leu Gln Gln Tyr Ile Asn Arg 
        835                 840                 845             


Cys Glu Ser Leu Phe Asn Asp Lys Lys Ala Lys Leu Arg Lys Leu Lys 
    850                 855                 860                 


Met Glu Gln Lys Asp Ile Pro Asp Gly Phe Ile Asp Arg Asp Leu Arg 
865                 870                 875                 880 


Asn Thr Gln Tyr Ile Ala Lys Lys Ala Leu Ala Met Leu Asn Glu Ile 
                885                 890                 895     


Cys Arg Arg Val Val Ala Thr Thr Gly Ser Ile Thr Asp Gln Leu Arg 
            900                 905                 910         


Glu Asp Trp Gln Leu Val Asp Val Met Lys Glu Leu Asn Leu Pro Lys 
        915                 920                 925             


Tyr Glu Ala Leu Gly Phe Val Glu Thr Tyr Glu Asp Lys Asp Gly Arg 
    930                 935                 940                 


Lys Ile Lys Arg Ile Lys Asp Trp Thr Lys Arg Asn Asp His Arg His 
945                 950                 955                 960 


His Ala Met Asp Ala Leu Thr Val Ala Phe Thr Lys Asp Ala Phe Ile 
                965                 970                 975     


Gln Tyr Phe Asn Asn Lys Asn Ala Ala Gln Asp Ser Gly Asn Arg Asn 
            980                 985                 990         


His Thr Asn Ile Ile Gly Ile Lys  Thr Arg Tyr Phe Asp  Lys Gly Arg 
        995                 1000                 1005             


Ala Leu  Pro Pro Ile Pro Leu  Glu Gln Phe Arg Ile  Glu Ala Lys 
    1010                 1015                 1020             


Gln His  Leu Glu Lys Leu Leu  Val Ser Ile Lys Ala  Lys Asn Lys 
    1025                 1030                 1035             


Val Val  Thr Val Asn Val Asn  Arg Thr Lys Lys Arg  Lys Gly Glu 
    1040                 1045                 1050             


Asn Thr  Lys Ile Gln Gln Thr  Pro Arg Gly Gln Leu  His Leu Glu 
    1055                 1060                 1065             


Thr Val  Tyr Gly Ser His Lys  Gln Tyr Val Thr Lys  Ile Glu Lys 
    1070                 1075                 1080             


Val Asn  Ala Ser Phe Asp Ala  Ala Lys Ile Ala Thr  Val Ser Lys 
    1085                 1090                 1095             


Arg Ala  Tyr Arg Asn Ala Leu  Leu Lys Arg Leu Glu  Thr Phe Gly 
    1100                 1105                 1110             


Asn Asp  Pro Lys Lys Ala Phe  Thr Gly Lys Asn Ala  Leu Glu Lys 
    1115                 1120                 1125             


Asn Pro  Leu Tyr Ala Asp Lys  Tyr Gln Thr Ile Arg  Val Pro Glu 
    1130                 1135                 1140             


Lys Val  Gln Thr Val Glu Phe  Glu Thr Ile Tyr Thr  Ile Arg Lys 
    1145                 1150                 1155             


Pro Val  Asp Pro Ala Leu Asn  Val Asp Lys Val Val  Asp Val Lys 
    1160                 1165                 1170             


Val Arg  Ala Ile Leu Glu Arg  Arg Leu Lys Glu Tyr  Gly Gly Asp 
    1175                 1180                 1185             


Pro Lys  Lys Ala Phe Val Asn  Phe Trp Glu Asn Pro  Ile Trp Leu 
    1190                 1195                 1200             


Asn Lys  Glu Lys Gly Ile Ser  Ile Lys Arg Val Ser  Ile Arg Gly 
    1205                 1210                 1215             


Ile Asn  Asn Ala Gln Ser Ile  His Val Lys Lys Asp  Lys Asn Gly 
    1220                 1225                 1230             


Asn Pro  Ile Trp Asp Glu Asn  Gly Lys Gln Ile Pro  Val Asp Phe 
    1235                 1240                 1245             


Val Asn  Thr Gly Asn Asn His  His Val Ala Ile Tyr  Arg Lys Pro 
    1250                 1255                 1260             


Val Leu  Asp Lys Lys Gly Gln  Val Thr Phe Asp Glu  Asp Gly Asn 
    1265                 1270                 1275             


Leu Met  Tyr Glu Leu Asp Glu  Val Val Val Pro Phe  Phe Glu Ala 
    1280                 1285                 1290             


Val Thr  Arg Ala Asn Leu Gly  Leu Pro Ile Ile Asp  Lys Asp Tyr 
    1295                 1300                 1305             


Arg Lys  Ser Glu Gly Trp Gln  Phe Leu Phe Ser Met  Lys Gln Asn 
    1310                 1315                 1320             


Glu Tyr  Phe Val Phe Pro Asn  Glu Lys Thr Gly Phe  Asn Pro Lys 
    1325                 1330                 1335             


Glu Val  Asp Leu Leu Asn Pro  Asp Asn Tyr Ala Met  Ile Ser Pro 
    1340                 1345                 1350             


Asn Leu  Phe Arg Val Gln Thr  Met Ser Lys Val Met  Tyr Gly Asn 
    1355                 1360                 1365             


Asn Val  Val Arg Asp Tyr Lys  Phe Arg His His Leu  Glu Thr Thr 
    1370                 1375                 1380             


Val Lys  Asp Met Lys Glu Leu  Lys Asp Ile Ala Tyr  Lys Gln Tyr 
    1385                 1390                 1395             


Lys Thr  Leu Ser Phe Gly Asn  Ser Val Val Lys Ile  Arg Ile Asn 
    1400                 1405                 1410             


His Ile  Gly Gln Ile Val Ser  Val Gly Glu Tyr 
    1415                 1420                 


<210> 85
<211> 1510
<212> PRT
<213> Bacteroides sp.


<220>
<223> Bacteroides sp. D2

<400> 85
Met Lys Arg Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Asp Ser Glu Glu Gln Arg Ile Leu Gly Met Gly Ser Arg 
            20                  25                  30          


Ile Ile Pro Met Asp Gln Gly Val Leu Asp Thr Phe Ser Gly Gly Asn 
        35                  40                  45              


Pro Val Glu Thr Gln Thr Ala Ala Arg Thr Ala Tyr Arg Gly Thr Arg 
    50                  55                  60                  


Arg Leu Arg Glu Arg Ala Leu Leu Arg Arg Glu Arg Leu Ile Arg Val 
65                  70                  75                  80  


Leu Asn Met Met Lys Phe Leu Pro Glu His Tyr Ala Ser Gln Ile Asp 
                85                  90                  95      


Phe Glu Lys Arg Leu Gly Gln Phe Phe Asp Glu Lys Glu Pro Lys Leu 
            100                 105                 110         


Ala Trp Lys Gln Asn Asp Glu Gly Arg Phe Glu Phe Ile Phe Gln Gln 
        115                 120                 125             


Ser Phe Asn Glu Met Ile Glu Glu Phe Lys Asn Lys Gly Val Val Arg 
    130                 135                 140                 


Glu Asp Lys Lys Ile Pro Tyr Asp Trp Thr Ile Tyr Tyr Leu Arg Lys 
145                 150                 155                 160 


Lys Ala Leu Ser Gln Glu Ile Glu Lys Glu Glu Leu Ala Trp Ile Leu 
                165                 170                 175     


Leu Asn Phe Asn Gln Lys Arg Gly Tyr Tyr Gln Leu Arg Gly Glu Glu 
            180                 185                 190         


Glu Glu Glu Asn Pro Asn Lys Leu Val Glu Tyr Tyr Ser Leu Lys Ile 
        195                 200                 205             


Val Asp Val Ile Ala Asp Glu Lys Pro Asn Ser Lys Gly Asp Ile Trp 
    210                 215                 220                 


Tyr Ser Leu His Leu Glu Asn Gly Trp Ile Tyr Arg Arg Ser Ser Lys 
225                 230                 235                 240 


Ile Pro Leu Phe Gly Trp Lys Asp Lys Thr Arg Asp Phe Ile Val Thr 
                245                 250                 255     


Thr Asp Leu Asn Asp Asp Gly Thr Val Lys Lys Asp Lys Glu Gly Ile 
            260                 265                 270         


Glu Lys Arg Ser Phe Arg Ala Pro Ser Glu Asn Asp Trp Val Leu Leu 
        275                 280                 285             


Lys Lys Lys Thr Glu Ser Asp Ile Glu Lys Ser His Lys Thr Val Gly 
    290                 295                 300                 


Ala Tyr Val Tyr Glu Thr Leu Leu Gln Asn Pro Met Gln Lys Val Arg 
305                 310                 315                 320 


Gly Lys Leu Val Arg Thr Ile Glu Arg Lys Phe Tyr Lys Asp Glu Leu 
                325                 330                 335     


Lys Gln Ile Leu Glu Lys Gln Arg Glu Phe His Pro Glu Leu Arg Asp 
            340                 345                 350         


Glu Asp Leu Tyr Asn Asp Cys Val Arg Glu Leu Tyr Arg Ser Asn Glu 
        355                 360                 365             


Thr Tyr Gln Phe Ile Leu Ser Lys Arg Asp Phe Val His Leu Phe Leu 
    370                 375                 380                 


Asp Asp Ile Leu Phe Tyr Gln Arg Pro Leu Arg Ser Gln Lys Ser Ala 
385                 390                 395                 400 


Ile Gly Asp Cys Ile Leu Glu Phe Lys Thr Tyr Lys Asp Lys Asp Gly 
                405                 410                 415     


Asn Asn Ile Lys Glu Tyr Leu Lys Val Ile Ser Lys Ser Asn Pro Leu 
            420                 425                 430         


Tyr Gln Glu Phe Arg Ile Trp Gln Trp Leu Tyr Asn Leu Lys Ile Tyr 
        435                 440                 445             


Arg Lys Glu Asp Asp Glu Asp Val Thr Leu Gln Phe Ile Ala Asn Ile 
    450                 455                 460                 


Glu Asp Lys Glu Gln Leu Phe Asp Phe Leu Ser Asn Arg Lys Ser Ile 
465                 470                 475                 480 


Glu Gln Lys Pro Leu Leu Glu Tyr Leu Ile Lys Ala Lys Gly Leu Lys 
                485                 490                 495     


Lys Gln Val Lys Thr Glu Ala Tyr Arg Trp Asn Tyr Val Glu Asp Lys 
            500                 505                 510         


Ile Tyr Pro Cys Ser Glu Thr Lys Thr Met Ile Ser Thr Arg Leu Ala 
        515                 520                 525             


Lys Val Glu Asn Ile Pro Asp Asn Phe Phe Thr Lys Glu Ile Glu Gln 
    530                 535                 540                 


Lys Leu Trp His Ile Ile Tyr Ser Val Thr Asp Lys Asn Glu Phe Glu 
545                 550                 555                 560 


Lys Ala Leu Arg Thr Phe Ala Lys Lys Tyr Asp Leu Asp Ile Ala Ser 
                565                 570                 575     


Phe Val Asp Asn Phe Lys Lys Ile Pro Pro Phe Lys Asn Glu Tyr Gly 
            580                 585                 590         


Ser Phe Ser Glu Lys Ala Ile Lys Lys Leu Leu Pro Leu Met Arg Leu 
        595                 600                 605             


Gly Lys Tyr Trp Lys Trp Asn Asp Ile Asp Asn Asn Thr Gln Asn Arg 
    610                 615                 620                 


Ile Ser Lys Ile Ile Thr Gly Glu Tyr Asp Glu Glu Ile Lys Asp Ile 
625                 630                 635                 640 


Val Arg Glu Lys Ser Ile Ala Leu Thr Asn Glu Asn Asp Phe Gln Gly 
                645                 650                 655     


Leu Gln Leu Trp Leu Ala Gln Tyr Leu Val Tyr Gly Arg His Ser Glu 
            660                 665                 670         


Ala Asp Ile Ala Gly Lys Trp His Ser Val Ala Asp Leu Glu Lys Tyr 
        675                 680                 685             


Leu Asn Glu Phe Lys Gln His Ser Leu Arg Asn Pro Ile Val Glu Gln 
    690                 695                 700                 


Ile Ile Thr Glu Thr Leu Arg Val Val Arg Asp Ile Trp Arg Lys Tyr 
705                 710                 715                 720 


Gly Gln Gly Ala Glu Asn Phe Phe Ser Glu Ile His Val Glu Leu Gly 
                725                 730                 735     


Arg Asp Met Lys Asn Thr Ala Asp Glu Arg Lys Lys Ile Val Asn Val 
            740                 745                 750         


Val Thr Glu Asn Glu Asn Thr Asn Leu Arg Ile Lys Ala Leu Leu Met 
        755                 760                 765             


Glu Leu Lys Asn Asn Ser Asp Gly Lys Leu Glu Val Glu Asn Val Arg 
    770                 775                 780                 


Pro Tyr Ser Pro Thr Gln Gln Asp Ile Leu Lys Ile Tyr Glu Glu Tyr 
785                 790                 795                 800 


Ala Ile Ser Thr Gly Leu Asp Asn Glu Lys Asp Glu Lys Val Lys Glu 
                805                 810                 815     


Asp Ile Lys Lys Ile Ser Arg Val Ala Gln Pro Thr Thr Thr Glu Leu 
            820                 825                 830         


Gln Arg Tyr Lys Leu Trp Leu Glu Gln Lys Tyr Cys Ser Pro Tyr Thr 
        835                 840                 845             


Gly Lys Val Ile Pro Leu Gly Lys Leu Phe Thr Glu Glu Tyr Gln Ile 
    850                 855                 860                 


Glu His Ile Ile Pro Lys Ser Arg Tyr Tyr Asp Asp Ser Phe Ser Asn 
865                 870                 875                 880 


Lys Val Ile Cys Glu Ala Ala Val Asn Lys Leu Lys Asp Lys Cys Leu 
                885                 890                 895     


Gly Leu Glu Phe Ile Lys Asn Tyr His Gly Gln Ile Val Glu Thr Gly 
            900                 905                 910         


Phe Gly Gln Lys Val Thr Ile Phe Asp Glu Glu Ala Tyr Gln Asn Phe 
        915                 920                 925             


Val Lys Gln His Tyr Ala Tyr Asn Arg Ser Lys Arg Thr Lys Leu Leu 
    930                 935                 940                 


Leu Glu Glu Ile Pro Glu Lys Met Ile Glu Arg Gln Met Asn Asp Thr 
945                 950                 955                 960 


Arg Tyr Ile Ser Lys Phe Val Leu Pro Leu Leu Ser Asn Leu Val Arg 
                965                 970                 975     


Ala Glu Glu Asn Asp Asn Gly Val Asn Ser Lys Asn Val Leu Pro Val 
            980                 985                 990         


Asn Gly Lys Ile Thr Thr Met Leu  Lys Gln Asp Trp Gly  Leu Asn Asp 
        995                 1000                 1005             


Val Trp  Asn Asp Leu Ile Leu  Pro Arg Phe Val Arg  Met Asn Glu 
    1010                 1015                 1020             


Leu Ala  Lys Thr Ile Ala Phe  Thr Ser Trp Asn Glu  Gln His Gln 
    1025                 1030                 1035             


Lys Tyr  Leu Pro Thr Val Pro  Leu Glu Leu Ser Lys  Gly Phe Gln 
    1040                 1045                 1050             


Lys Lys  Arg Ile Asp His Arg  His His Ala Met Asp  Ala Leu Val 
    1055                 1060                 1065             


Ile Ala  Cys Ala Thr Arg Asp  His Val Asn Leu Leu  Asn Asn Lys 
    1070                 1075                 1080             


His Ala  Asn Thr Asp Thr Ile  Arg Tyr Asp Leu Gln  Arg Lys Leu 
    1085                 1090                 1095             


Arg Leu  Phe Glu Arg Val Thr  Tyr Ile Asp Pro Gln  Thr Lys Asn 
    1100                 1105                 1110             


Asn Val  Thr Lys Asp Ile Pro  Lys Glu Phe Lys Lys  Pro Trp Asp 
    1115                 1120                 1125             


Asn Phe  Thr Val Asp Ala Arg  Asn Glu Leu Glu Lys  Ile Ile Val 
    1130                 1135                 1140             


Ser Phe  Lys Gln Asn Leu Arg  Ile Ile Asn Lys Ala  Thr Asn Ile 
    1145                 1150                 1155             


Tyr Thr  Lys Tyr Glu Asn Gly  Lys Lys Ile Lys Val  Gly Gln Lys 
    1160                 1165                 1170             


Gly Leu  Asn Trp Ala Ile Arg  Lys Pro Leu His Lys  Glu Thr Val 
    1175                 1180                 1185             


Phe Ala  Lys Val Ser Leu Arg  Lys Arg Lys Thr Val  Arg Leu Ser 
    1190                 1195                 1200             


Glu Ala  Leu Lys Asp Trp Lys  Lys Ile Val Asp Lys  Lys Leu Lys 
    1205                 1210                 1215             


Gln Glu  Ile Lys Arg Leu Thr  Cys Gln Tyr Gly Lys  Phe Asp Val 
    1220                 1225                 1230             


Asp Thr  Ile Leu Arg Tyr Phe  Lys Asp Arg Lys Tyr  Gln Phe Gly 
    1235                 1240                 1245             


Glu Val  Asp Val Ser Lys Val  Lys Met Tyr Tyr Phe  Asp Glu Glu 
    1250                 1255                 1260             


Asn Ala  Ala Val Arg Lys Asn  Val Asp Thr Ser Phe  Thr Glu Lys 
    1265                 1270                 1275             


Phe Ile  Gln Gly Ser Val Thr  Asp Thr Gly Ile Gln  Lys Ile Leu 
    1280                 1285                 1290             


Leu Asn  His Leu Glu Ala Lys  Gly Asn Lys Val Glu  Ile Ala Phe 
    1295                 1300                 1305             


Ser Pro  Glu Gly Ile Glu Glu  Met Asn Lys Asn Ile  Ile Gln Leu 
    1310                 1315                 1320             


Asn Glu  Gly Lys Leu His Leu  Pro Ile Phe Lys Val  Arg Val Tyr 
    1325                 1330                 1335             


Glu Thr  Ile Gly Asn Lys Phe  Ser Val Gly Val Lys  Gly Asn Lys 
    1340                 1345                 1350             


Lys Asp  Lys Tyr Val Glu Ala  Ala Lys Gly Thr Asn  Leu Phe Phe 
    1355                 1360                 1365             


Ala Ile  Tyr Val Asp Glu Asn  Gly Ile Arg Ser Tyr  Glu Thr Ile 
    1370                 1375                 1380             


Pro Leu  Asn Ile Val Ile Glu  Arg Leu Lys Gln Gly  Leu Ser Val 
    1385                 1390                 1395             


Val Pro  Glu Lys Asn Arg Lys  Glu His Ser Leu Leu  Phe Tyr Leu 
    1400                 1405                 1410             


Ser Pro  Asn Asp Leu Val Tyr  Val Pro Ile Glu Asp  Glu Arg Glu 
    1415                 1420                 1425             


Asn Ile  His Ala Val Asn Leu  Asp Gln Leu Asn Asn  Glu Gln Arg 
    1430                 1435                 1440             


Lys Arg  Ile Tyr Lys Met Val  Ser Cys Thr Gly Ser  Glu Cys His 
    1445                 1450                 1455             


Phe Val  Pro Tyr Tyr Val Ala  Ser Pro Ile Val Asn  Lys Val Glu 
    1460                 1465                 1470             


Tyr Ser  Ser Leu Asn Lys Ile  Gly Arg Ser Leu Thr  Gly Glu Met 
    1475                 1480                 1485             


Ile Lys  Asp Val Cys Ile Lys  Leu Lys Val Asp Arg  Leu Gly Asn 
    1490                 1495                 1500             


Val Lys  Gly Ile Ser Gly Leu  
    1505                 1510 


<210> 86
<211> 1436
<212> PRT
<213> Bacteroides sp.


<220>
<223> Bacteroides sp. D2

<400> 86
Met Lys Arg Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Asp Glu Ala Glu Asn Lys Asp Glu Arg Ser Ser Ile Val 
            20                  25                  30          


Lys Leu Gly Val Arg Val Asn Pro Leu Thr Val Asp Glu Leu Thr Asn 
        35                  40                  45              


Phe Glu Lys Gly Lys Ser Ile Thr Thr Asn Ala Asp Arg Thr Leu Lys 
    50                  55                  60                  


Arg Gly Met Arg Arg Asn Leu Gln Arg Tyr Lys Leu Arg Arg Glu Thr 
65                  70                  75                  80  


Leu Met Glu Val Leu Lys Glu His Lys Leu Ile Thr Glu Asp Thr Ile 
                85                  90                  95      


Leu Ser Glu Asn Gly Asn Arg Thr Thr Phe Glu Thr Tyr Arg Leu Arg 
            100                 105                 110         


Ala Lys Ala Ala Thr Glu Lys Ile Ser Leu Glu Glu Phe Ala Arg Val 
        115                 120                 125             


Leu Leu Met Ile Asn Lys Lys Arg Gly Tyr Lys Ser Cys Arg Lys Ala 
    130                 135                 140                 


Lys Gly Ala Glu Glu Gly Thr Leu Ile Asp Gly Met Asp Ile Ala Arg 
145                 150                 155                 160 


Glu Leu Tyr Asn Asn Asn Leu Thr Pro Gly Glu Leu Cys Leu Gln Leu 
                165                 170                 175     


Leu Asp Ala Gly Lys Lys Tyr Leu Pro Asp Phe Tyr Arg Ser Asp Leu 
            180                 185                 190         


Gln Asn Glu Leu Asp Arg Ile Trp Glu Lys Gln Lys Glu Tyr Tyr Pro 
        195                 200                 205             


Glu Ile Leu Thr Glu Val Leu Lys Glu Glu Leu Arg Gly Lys Lys Arg 
    210                 215                 220                 


Asp Ala Val Trp Ala Ile Cys Ala Lys Ser Phe Val Trp Glu Glu Tyr 
225                 230                 235                 240 


Tyr Thr Glu Trp Asn Lys Glu Lys Gly Lys Thr Glu Gln Gln Glu Arg 
                245                 250                 255     


Glu His Lys Leu Glu Gly Ile Tyr Ser Lys Arg Lys Arg Asp Glu Ala 
            260                 265                 270         


Lys Arg Glu Asn Leu Gln Trp Arg Val Asn Gly Leu Lys Glu Lys Leu 
        275                 280                 285             


Ser Leu Glu Gln Leu Val Ile Val Leu Gln Glu Met Asn Ile Gln Ile 
    290                 295                 300                 


Asn Asn Ser Ser Gly Tyr Leu Gly Ala Ile Ser Asp Arg Ser Lys Glu 
305                 310                 315                 320 


Leu Tyr Phe Asn Lys Gln Thr Val Gly Gln Tyr Gln Met Glu Met Leu 
                325                 330                 335     


Asp Lys Asn Pro Asn Ala Ser Leu Arg Asn Met Val Phe Tyr Arg Gln 
            340                 345                 350         


Asp Tyr Leu Asp Glu Phe Asn Thr Leu Trp Glu Lys Gln Ala Glu Tyr 
        355                 360                 365             


His Lys Glu Leu Thr Gly Glu Leu Lys Lys Glu Ile Arg Asp Ile Val 
    370                 375                 380                 


Ile Phe Tyr Gln Arg Arg Leu Lys Ser Gln Lys Gly Leu Val Gly Phe 
385                 390                 395                 400 


Cys Glu Phe Glu Ser Arg Gln Ile Glu Val Glu Ile Asp Gly Lys Lys 
                405                 410                 415     


Lys Ile Lys Thr Val Gly Asn Arg Val Ile Pro Arg Ser Ser Pro Leu 
            420                 425                 430         


Phe Gln Glu Phe Lys Ile Trp Gln Ile Leu Asn Asn Ile Glu Val Thr 
        435                 440                 445             


Val Val Gly Lys Lys Gly Lys Arg Arg Lys Gln Lys Asp Asn Ser Pro 
    450                 455                 460                 


Thr Leu Phe Asp Gly Leu Asp Asp Thr Glu Gln Leu Glu Leu Asn Gly 
465                 470                 475                 480 


Ser Arg Tyr Leu Tyr Gln Glu Glu Lys Glu Leu Leu Ala Gln Glu Leu 
                485                 490                 495     


Phe Val Arg Asp Lys Met Thr Lys Ser Asp Val Leu Lys Leu Leu Phe 
            500                 505                 510         


Asp Asn Pro Gln Glu Leu Asp Leu Asn Phe Lys Thr Ile Asp Gly Asn 
        515                 520                 525             


Lys Thr Gly Tyr Thr Leu Phe Gln Ala Tyr Ser Lys Met Ile Glu Met 
    530                 535                 540                 


Ser Gly His Glu Pro Val Asp Phe Lys Lys Thr Val Glu Lys Val Val 
545                 550                 555                 560 


Glu His Val Lys Ala Val Phe Asp Leu Leu Asn Trp Asn Thr Asp Ile 
                565                 570                 575     


Leu Gly Phe Asn Ser Asn Glu Glu Leu Asp Asn Gln Ser Tyr Tyr Lys 
            580                 585                 590         


Leu Trp His Leu Leu Tyr Ser Phe Glu Gly Asp Asn Thr Pro Thr Gly 
        595                 600                 605             


Asn Ala Arg Leu Val Gln Lys Ile Thr Glu Leu Tyr Gly Phe Glu Lys 
    610                 615                 620                 


Glu Tyr Ala Ile Ile Leu Ala Asn Val Thr Phe Gln Asp Asp Tyr Gly 
625                 630                 635                 640 


Ser Leu Ser Ala Lys Ala Ile His Lys Ile Leu Pro His Leu Lys Glu 
                645                 650                 655     


Gly Asn Arg Tyr Asp Val Ala Cys Ala Tyr Ala Gly Tyr Lys His Ser 
            660                 665                 670         


Glu Ser Ser Leu Thr Lys Glu Glu Ile Ala Asn Lys Ala Leu Lys Asp 
        675                 680                 685             


Arg Leu Thr Leu Leu Pro Lys Asn Asn Leu Arg Asn Pro Val Val Glu 
    690                 695                 700                 


Lys Ile Leu Asn Gln Met Val Asn Val Ile Asn Ala Ile Ile Asp Thr 
705                 710                 715                 720 


Tyr Gly Lys Pro Asp Glu Ile Arg Val Glu Leu Ala Arg Glu Leu Lys 
                725                 730                 735     


Lys Asn Ala Lys Glu Arg Glu Glu Leu Thr Lys Phe Ile Ala Glu Thr 
            740                 745                 750         


Thr Arg Lys His Glu Glu Phe Lys Ile Leu Leu Gln Ser Glu Phe Gly 
        755                 760                 765             


Leu Thr Asn Val Ser Arg Thr Asp Ile Leu Arg Tyr Lys Leu Tyr Lys 
    770                 775                 780                 


Glu Leu Glu Ser Cys Gly Tyr Lys Thr Leu Tyr Ser Asn Thr Tyr Ile 
785                 790                 795                 800 


Pro Arg Glu Lys Leu Phe Ser Lys Glu Phe Asp Ile Glu His Ile Ile 
                805                 810                 815     


Pro Gln Ala Arg Leu Phe Asp Asp Ser Phe Ser Asn Lys Thr Leu Glu 
            820                 825                 830         


Ala Arg Ser Ile Asn Leu Glu Lys Gly Asn Lys Thr Ala Tyr Asp Phe 
        835                 840                 845             


Val Lys Glu Lys Phe Gly Glu Ser Gly Ala Asp Asn Ser Leu Asp His 
    850                 855                 860                 


Tyr Leu Asn Asn Ile Glu Asp Leu Phe Lys Ser Gly Lys Ile Ser Lys 
865                 870                 875                 880 


Thr Lys Tyr Asn Lys Leu Lys Met Ala Glu Gln Asp Ile Pro Asp Gly 
                885                 890                 895     


Phe Ile Asn Arg Asp Leu Arg Asn Thr Gln Tyr Ile Ala Lys Lys Ala 
            900                 905                 910         


Leu Ser Met Leu Asn Glu Ile Ser Arg Arg Val Val Ala Thr Ser Gly 
        915                 920                 925             


Thr Ile Thr Asp Lys Leu Arg Gln Asp Trp Gln Leu Val Asp Val Met 
    930                 935                 940                 


Lys Glu Leu Asn Trp Glu Lys Tyr Lys Ala Leu Gly Leu Val Glu Tyr 
945                 950                 955                 960 


Phe Glu Asp Lys Asp Gly Arg Gln Ile Gly Arg Ile Lys Asp Trp Thr 
                965                 970                 975     


Lys Arg Asn Asp His Arg His His Ala Met Asp Ala Leu Thr Val Ala 
            980                 985                 990         


Phe Thr Lys Asp Ile Phe Ile Gln  Tyr Phe Asn Asn Lys  Asn Ala Ser 
        995                 1000                 1005             


Leu Asn  Ser Asn Thr Asn Glu  Tyr Ala Ile Lys Asn  Lys Tyr Phe 
    1010                 1015                 1020             


Gln Asn  Gly Arg Ala Ile Ala  Pro Ile Pro Leu Arg  Glu Phe Arg 
    1025                 1030                 1035             


Val Glu  Ala Lys Lys His Leu  Glu Asn Thr Leu Ile  Ser Ile Lys 
    1040                 1045                 1050             


Ala Lys  Asn Lys Val Val Thr  Gly Asn Ile Asn Lys  Thr Lys Lys 
    1055                 1060                 1065             


Arg Gly  Gly Val Asn Lys Tyr  Leu Gln Gln Thr Pro  Arg Gly Gln 
    1070                 1075                 1080             


Leu His  Leu Glu Thr Ile Tyr  Gly Ser Gly Lys Gln  Tyr Leu Thr 
    1085                 1090                 1095             


Lys Glu  Glu Lys Val Asn Ala  Ser Phe Asp Met Lys  Lys Ile Ala 
    1100                 1105                 1110             


Thr Val  Ser Lys Ser Ala Tyr  Arg Asp Val Leu Leu  Lys Arg Leu 
    1115                 1120                 1125             


His Glu  Asn Asp Asn Asp Pro  Lys Lys Ala Phe Thr  Gly Lys Asn 
    1130                 1135                 1140             


Ser Leu  Asp Lys Gln Pro Ile  Trp Leu Asp Lys Glu  Gln Thr Arg 
    1145                 1150                 1155             


Lys Val  Pro Glu Lys Val Lys  Thr Val Thr Leu Glu  Thr Ile Tyr 
    1160                 1165                 1170             


Thr Val  Arg Lys Glu Ile Ser  Pro Asp Leu Lys Val  Asp Lys Val 
    1175                 1180                 1185             


Ile Asp  Ala Gly Val Arg Lys  Ile Leu Thr Gly Arg  Leu Asn Glu 
    1190                 1195                 1200             


Tyr Gly  Asn Asp Ala Lys Lys  Ala Phe Ser Asn Leu  Asp Glu Asn 
    1205                 1210                 1215             


Pro Ile  Trp Leu Asn Lys Glu  Lys Gly Ile Ser Ile  Lys Arg Val 
    1220                 1225                 1230             


Thr Ile  Ser Gly Ile Ser Asn  Ala Gln Ser Leu His  Val Lys Lys 
    1235                 1240                 1245             


Asp Lys  Asp Gly Lys Pro Ile  Leu Asp Glu Asp Ser  Arg Asn Ile 
    1250                 1255                 1260             


Pro Val  Asp Phe Val Asn Thr  Gly Asn Asn His His  Val Ala Val 
    1265                 1270                 1275             


Tyr Arg  Arg Pro Val Ile Asp  Lys Arg Gly Gln Leu  Val Ile Asp 
    1280                 1285                 1290             


Glu Ala  Gly Asn Pro Lys Tyr  Glu Leu Glu Glu Val  Val Val Ser 
    1295                 1300                 1305             


Phe Phe  Glu Ala Val Thr Arg  Ala Asn Leu Gly Gln  Pro Ile Ile 
    1310                 1315                 1320             


Asp Lys  Asp Tyr Lys Thr Ser  Glu Gly Trp Gln Phe  Leu Phe Ser 
    1325                 1330                 1335             


Met Lys  Gln Asn Glu Tyr Phe  Val Phe Pro Asn Glu  Lys Thr Gly 
    1340                 1345                 1350             


Phe Asn  Pro Lys Glu Ile Asp  Leu Leu Asp Ala Glu  Asn Tyr Gly 
    1355                 1360                 1365             


Val Ile  Ser Pro Asn Leu Phe  Arg Val Gln Lys Phe  Ala His Lys 
    1370                 1375                 1380             


Asn Tyr  Val Phe Arg His His  Leu Glu Thr Thr Ile  Lys Asp Thr 
    1385                 1390                 1395             


Ser Ser  Ile Leu Lys Gly Ile  Thr Trp Ile Asp Phe  Arg Ser Ser 
    1400                 1405                 1410             


Lys Gly  Leu Asp Ala Ile Val  Lys Val Arg Val Asn  His Ile Gly 
    1415                 1420                 1425             


Gln Ile  Val Ser Val Gly Glu  Tyr 
    1430                 1435     


<210> 87
<211> 1508
<212> PRT
<213> Bacteroides uniformis


<220>
<223> Bacteroides uniformis CL03T00C23

<400> 87
Met Arg Thr Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Val Ile Asn Ser Val Ile Lys Glu Gln Thr Glu Arg Ile Trp Ile 
            20                  25                  30          


Glu Met Ala Gly Ser Arg Ile Ile Pro Met Asp Ala Ala Ile Leu Gly 
        35                  40                  45              


Asp Phe Asp Lys Gly Asn Ser Ile Ser Gln Thr Ala Glu Arg Thr Arg 
    50                  55                  60                  


Phe Arg Gly Val Arg Arg Leu Arg Glu Arg Gln Leu Leu Arg Arg Glu 
65                  70                  75                  80  


Arg Leu His Lys Val Leu Lys Ile Leu Gly Phe Leu Pro Glu His Tyr 
                85                  90                  95      


Leu Lys Gly Ile Asp Phe Glu Lys His Thr Gly Lys Phe Leu Ser Gly 
            100                 105                 110         


Ser Glu Pro Lys Leu Pro Trp Val Lys Asp Arg Trp Gly Lys Tyr Ser 
        115                 120                 125             


Phe Leu Phe Gln Thr Ala Phe Asn Glu Met Leu Ala Asp Phe Ala Lys 
    130                 135                 140                 


His Gln Pro Ser Leu Val Phe Asp Gly Lys Lys Ile Pro Tyr Asp Trp 
145                 150                 155                 160 


Thr Val Tyr Tyr Leu Arg Lys Lys Ala Leu Thr Glu Met Ile Ser Lys 
                165                 170                 175     


Glu Glu Leu Ala Trp Ile Leu Leu Asn Phe Asn Gln Lys Arg Gly Tyr 
            180                 185                 190         


Tyr Gln Leu Arg Gly Glu Glu Glu Glu Asp Asn Ala Gly Lys Ser Val 
        195                 200                 205             


Glu Phe Tyr Ala Leu Lys Val Leu Ser Val Glu Ala Thr Asp Glu Lys 
    210                 215                 220                 


Lys Gly Arg Asp Ile Trp Tyr Asn Val His Leu Glu Asn Gly Trp Val 
225                 230                 235                 240 


Tyr Arg Arg Ser Ser Asn Val Pro Leu Asp Trp Glu Gly Arg Val Lys 
                245                 250                 255     


Glu Phe Ile Val Thr Thr Asp Leu Asn Pro Asp Gly Thr Pro Lys Leu 
            260                 265                 270         


Asp Lys Tyr Gly Glu Val Lys Arg Ser Phe Arg Ala Pro Lys Glu Asp 
        275                 280                 285             


Asp Trp Met Leu Ile Lys Lys Arg Thr Glu Ala Asp Ile Thr Gly Thr 
    290                 295                 300                 


His Lys Thr Ile Gly Ser Tyr Ile Tyr Asp Ala Leu Leu Gln Glu Pro 
305                 310                 315                 320 


Gln Gln Lys Ile Ile Gly Lys Leu Val Lys Thr Val Glu Arg Lys Phe 
                325                 330                 335     


Tyr Lys Glu Glu Leu Asn Phe Ile Leu Gln Lys Gln Cys Ala Phe His 
            340                 345                 350         


Ala Glu Leu Gln Asp Arg Asp Leu Tyr Met Arg Cys Ile Glu Ala Leu 
        355                 360                 365             


Tyr Pro Gly Asn Glu Val Gln Arg Arg Asn Ile Ala Asn Arg Asp Phe 
    370                 375                 380                 


Ile Tyr Leu Leu Ile Asp Asp Val Leu Phe Tyr Gln Arg Pro Leu Lys 
385                 390                 395                 400 


Thr Lys Lys Ser Leu Ile Ala Asn Cys Pro Tyr Glu Glu Asn Glu Tyr 
                405                 410                 415     


Val Asn Arg Lys Thr Gly Glu Ile Lys Thr Ala Pro Leu Lys Cys Ile 
            420                 425                 430         


Ala Lys Ser His Pro Leu Phe Gln Glu Phe Arg Leu Trp Tyr Phe Leu 
        435                 440                 445             


Ser Asn Ile Arg Val Tyr Gln Lys Glu Arg Glu Val Asn Gly Thr Leu 
    450                 455                 460                 


His Leu Asp Val Asp Val Thr Thr Glu Phe Leu Lys Thr Glu Asp Asp 
465                 470                 475                 480 


Tyr Val Ala Leu Phe Asp Trp Leu Asn Ser Arg Lys Glu Ile Asp Gln 
                485                 490                 495     


Lys Ala Phe Leu Arg Tyr Pro Ala Phe Gly Leu Lys Lys Glu Ile Asn 
            500                 505                 510         


Asn Tyr Arg Trp Asn Tyr Val Glu Asp Lys Phe Tyr Pro Cys Asn Glu 
        515                 520                 525             


Thr Arg His Ala Ile Leu Ser Arg Leu Glu Lys Ala Gly Ile Gly Ile 
    530                 535                 540                 


Asp Phe Leu Ser Asp Glu Lys Glu Thr Ala Leu Trp His Ile Leu Tyr 
545                 550                 555                 560 


Ser Val Ser Asp Lys Gln Glu Ile Glu Lys Ala Leu Ala Thr Phe Ala 
                565                 570                 575     


Val Lys Asn Gly Leu Asn Glu Ser Phe Val Glu Val Phe Lys Lys Phe 
            580                 585                 590         


Pro Pro Phe Lys Ser Glu Tyr Gly Ala Tyr Ser Ala Lys Ala Ile Lys 
        595                 600                 605             


Lys Leu Leu Pro Leu Met Arg Cys Gly Lys Tyr Trp Asp Met Ser Leu 
    610                 615                 620                 


Ile Asp Gly Thr Thr Lys Glu Arg Ile Glu Arg Ile Ile Ala Gly Glu 
625                 630                 635                 640 


Cys Asp Glu Ser Ile Gly Ala Lys Val Arg Glu Lys Ala Met Asn Leu 
                645                 650                 655     


Ser Asp Ile Ser Cys Phe Lys Arg Leu Pro Leu Trp Leu Ala Cys Tyr 
            660                 665                 670         


Val Val Tyr Asn Arg His Ser Glu Asp Lys Glu Ile Thr Lys Trp Glu 
        675                 680                 685             


Thr Pro Ala Asp Ile Asp Ala Tyr Leu Ala Ala Phe Lys Gln His Ser 
    690                 695                 700                 


Leu Arg Asn Pro Ile Val Glu Gln Val Ile Thr Glu Thr Leu Arg Val 
705                 710                 715                 720 


Val Arg Asp Ile Trp Lys Gln Val Gly Lys Ile Asp Glu Ile Arg Ile 
                725                 730                 735     


Glu Leu Gly Arg Glu Met Lys Asn Pro Ala Asp Lys Arg Lys Arg Met 
            740                 745                 750         


Thr Thr Gln Ile Leu Glu Asn Glu Asn Ala Asn Leu Arg Ile Lys Ala 
        755                 760                 765             


Leu Leu Ala Glu Phe Val Asn Pro Glu Tyr Gly Val Glu Asn Val Arg 
    770                 775                 780                 


Pro Tyr Ser Pro Ser Gln Gln Glu Ile Leu Arg Ile Tyr Glu Asp Ala 
785                 790                 795                 800 


Val Leu Lys Gly Glu Glu Gln Ile Pro Glu Asp Ile Asp Val Ile Leu 
                805                 810                 815     


Lys Lys Phe Asn Thr Ser Lys Leu Pro Thr Lys Ser Glu Phe Leu Arg 
            820                 825                 830         


Tyr Lys Leu Trp Leu Glu Gln Lys Tyr Arg Ser Pro Tyr Thr Gly Glu 
        835                 840                 845             


Leu Ile Pro Leu Ala Lys Leu Phe Thr Ala Ala Tyr Glu Ile Glu His 
    850                 855                 860                 


Val Ile Pro Gln Ser Arg Tyr Phe Asp Asp Ser Phe Ser Asn Lys Val 
865                 870                 875                 880 


Ile Cys Glu Ser Ala Val Asn Lys Leu Lys Asp Asn Gln Leu Gly Tyr 
                885                 890                 895     


Glu Phe Ile Lys Asn His His Gly Gln Lys Val Glu Val Gly Phe Gly 
            900                 905                 910         


Lys Thr Val Glu Ile Phe Ser Val Asp Ser Tyr Glu Arg Phe Val Lys 
        915                 920                 925             


Glu Gln Tyr Ala Lys Ser Gly Ile Lys Met Lys Lys Leu Leu Met Asp 
    930                 935                 940                 


Asp Ile Pro Glu Gln Phe Ile Glu Arg Gln Leu Asn Asp Ser Arg Tyr 
945                 950                 955                 960 


Ile Ser Lys Val Val Lys Gly Leu Leu Ser Asn Ile Val Arg Glu Lys 
                965                 970                 975     


Asn Asp Ser Gly Glu Tyr Glu Pro Glu Ala Val Ser Lys Asn Ile Leu 
            980                 985                 990         


Val Cys Thr Gly Ser Val Thr Asp  Arg Leu Lys Lys Asp  Trp Gly Met 
        995                 1000                 1005             


Asn Asp  Val Trp Asn Ser Ile  Val Ser Pro Arg Phe  Glu Arg Leu 
    1010                 1015                 1020             


Asn Ala  Leu Thr Glu Thr Gln  Cys Phe Gly His Trp  Glu Asn Lys 
    1025                 1030                 1035             


Asp Gly  Lys Lys Val Phe Gln  Thr Ala Val Pro Leu  Glu Tyr Gln 
    1040                 1045                 1050             


Lys Gly  Phe Ser Lys Lys Arg  Ile Asp His Arg His  His Ala Met 
    1055                 1060                 1065             


Asp Ala  Ile Val Ile Ala Cys  Ala Thr Arg Asn His  Val Asn Tyr 
    1070                 1075                 1080             


Leu Asn  Asn Glu Ser Ala Ser  Arg Asn Ala Lys Ile  Ser Arg Tyr 
    1085                 1090                 1095             


Asp Leu  Gln Arg Leu Leu Cys  Asp Lys Ser Arg Gly  Asp Gly Asn 
    1100                 1105                 1110             


Gly Asn  Tyr Arg Trp Ile Ile  Lys Lys Pro Trp Thr  Thr Phe Thr 
    1115                 1120                 1125             


Gln Asp  Ala Arg Glu Ala Leu  Ser Gly Ile Ile Val  Ser Leu Lys 
    1130                 1135                 1140             


Gln Asn  Leu Arg Ile Ile Asn  Lys Thr Thr Asn Ile  Tyr Gln His 
    1145                 1150                 1155             


Phe Asp  Ala Asn Gly Thr Arg  Val Tyr Glu Lys Gln  Lys Ile Gly 
    1160                 1165                 1170             


Asp Ser  Trp Ala Ile Arg Lys  Pro Met His Lys Asp  Thr Val Phe 
    1175                 1180                 1185             


Gly Ala  Val Asn Leu Arg Lys  Val Lys Val Val Arg  Leu Ser Val 
    1190                 1195                 1200             


Ala Leu  Asp Thr Pro Ser Met  Ile Val Asn Lys Arg  Val Lys Asn 
    1205                 1210                 1215             


Lys Val  Leu Glu Leu Leu Ser  Tyr Lys Tyr Asp Lys  Lys Lys Ile 
    1220                 1225                 1230             


Glu Lys  Tyr Phe Lys Glu Asn  Ala Phe Leu Trp Lys  Glu Leu Asp 
    1235                 1240                 1245             


Ile Ala  Lys Val Ala Val Tyr  Tyr Phe Thr Glu Asn  Thr Thr Glu 
    1250                 1255                 1260             


Pro Leu  Val Ala Val Arg Lys  Ser Leu Asp Ser Thr  Phe Asn Glu 
    1265                 1270                 1275             


Lys Lys  Ile Ala Ser Val Thr  Asp Thr Gly Ile Gln  Lys Ile Leu 
    1280                 1285                 1290             


Leu Asn  His Leu Lys Ser Lys  Glu Gly Lys Ala Glu  Leu Ala Phe 
    1295                 1300                 1305             


Ser Ala  Glu Gly Ile Glu Glu  Met Asn Arg Asn Leu  Leu Gln Leu 
    1310                 1315                 1320             


Asn Asp  Gly Lys Gly His Gln  Pro Ile Tyr Lys Val  Arg Val Tyr 
    1325                 1330                 1335             


Glu Pro  Arg Gly Asn Lys Phe  Lys Val Gly Val Leu  Gly Asn Lys 
    1340                 1345                 1350             


Gly Ala  Lys Trp Val Glu Ala  Ala Lys Gly Thr Asn  Leu Phe Phe 
    1355                 1360                 1365             


Ala Ile  Tyr Ile Thr Glu Asp  Gly Asn Arg Thr Tyr  Glu Thr Ile 
    1370                 1375                 1380             


Pro Leu  Asn Trp Val Ile Glu  Arg Glu Lys Gln Gly  Leu Val Pro 
    1385                 1390                 1395             


Val Pro  Asp Arg Asn Glu Lys  Gly Asp Lys Leu Leu  Phe Trp Leu 
    1400                 1405                 1410             


Ser Pro  Asn Asp Leu Val Tyr  Leu Pro Thr Glu Glu  Glu Arg Asp 
    1415                 1420                 1425             


Phe Gly  Arg Ile Asn Glu Pro  Ile Asp Arg Gly Arg  Ile Tyr Lys 
    1430                 1435                 1440             


Met Val  Ser Ser Ser Gly Asn  Gln Cys Phe Phe Ile  Pro Gln Ser 
    1445                 1450                 1455             


Ile Ser  Asn Ala Ile Ile Ser  Thr Lys Glu Leu Gly  Ser Asn Asn 
    1460                 1465                 1470             


Lys Ala  Glu Lys Ser Trp Asp  Gly Glu Met Ile Lys  Asn Ile Cys 
    1475                 1480                 1485             


Ile Pro  Val Lys Val Asp Arg  Leu Gly Arg Ile Ile  Glu Val Lys 
    1490                 1495                 1500             


Tyr Arg  Val Asn Glu 
    1505             


<210> 88
<211> 1504
<212> PRT
<213> Bacteroides vulgatus


<220>
<223> Bacteroides vulgatus CL09T03C04

<400> 88
Met Lys Asn Ile Val Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Val Val Asn Gly Ser Val Asn Asp Asp Gly Ser Glu Gln Leu Val 
            20                  25                  30          


Lys Ile Gln Ala Ser Gly Ser Arg Ile Ile Pro Met Asp Ala Ala Met 
        35                  40                  45              


Ile Gly Asp Phe Asn Lys Gly Asn Ser Ile Ser Gln Thr Ala Glu Arg 
    50                  55                  60                  


Thr Arg Leu Arg Gly Val Arg Arg Leu Ser Glu Arg Tyr Leu Leu Arg 
65                  70                  75                  80  


Arg Glu Arg Leu His Arg Ile Leu Asp Ile Leu Gly Phe Leu Pro Phe 
                85                  90                  95      


His Phe Ala Gln Asp Leu Asp Arg His Gly Lys Ile Val Lys Gly Lys 
            100                 105                 110         


Glu Pro Lys Leu Ala Trp Arg Lys Asn Glu Ala Gly Gln Phe Glu Phe 
        115                 120                 125             


Ile Phe Gln Asp Ser Phe Lys Glu Met Leu Glu Asp Phe Lys Leu Asn 
    130                 135                 140                 


His Pro Asn Leu Ile Thr Asp Asp Lys Lys Val Pro Tyr Asp Trp Thr 
145                 150                 155                 160 


Ile Tyr Tyr Leu Arg Lys Lys Gly Leu Thr Ser Lys Ile Ser Lys Glu 
                165                 170                 175     


Glu Leu Ala Trp Ile Leu Leu Asn Phe Asn Gln Lys Arg Gly Tyr Tyr 
            180                 185                 190         


Gln Leu Arg Gly Glu Glu Glu Glu Glu Asn Lys Asn Lys Leu Val Glu 
        195                 200                 205             


Phe Tyr Ala Leu Lys Val Val Ala Val Glu Asp Ser Gly Glu Lys Lys 
    210                 215                 220                 


Gly Lys Asp Ile Trp Tyr Asn Val His Leu Glu Asn Gly Trp Val Tyr 
225                 230                 235                 240 


Arg Arg Thr Ser Asn Met Pro Leu Asp Trp Val Gly Lys Thr Lys Glu 
                245                 250                 255     


Phe Ile Val Thr Thr Asp Leu Glu Lys Asp Gly Thr Pro Lys Lys Asp 
            260                 265                 270         


Lys Glu Gly Asn Val Lys Arg Ser Phe Arg Ala Pro Lys Glu Asp Asp 
        275                 280                 285             


Trp Ser Leu Leu Lys Lys Lys Thr Glu Ala Asp Ile Asp Gln Thr His 
    290                 295                 300                 


Lys Thr Val Gly Val Tyr Ile Tyr Asp Thr Leu Leu Gly Asn Pro Ser 
305                 310                 315                 320 


Gln Lys Ile Arg Gly Arg Leu Val Arg Thr Ile Glu Arg Lys Tyr Tyr 
                325                 330                 335     


Lys Glu Glu Leu Lys Gln Ile Leu Glu Lys Gln Lys Glu Phe His Leu 
            340                 345                 350         


Glu Leu Gln Asp Arg Ala Leu Tyr Ala Ala Cys Ile Glu Glu Leu Tyr 
        355                 360                 365             


Pro Ile Asn Glu Ala His Arg Asn Asn Val Gly Asn Arg Asp Phe Thr 
    370                 375                 380                 


Tyr Leu Phe Leu Glu Asp Ile Leu Phe Tyr Gln Arg Pro Leu Lys Ser 
385                 390                 395                 400 


Lys Lys Ser Leu Ile Asp Asn Cys Pro Tyr Glu Glu Asn Gln Gly Leu 
                405                 410                 415     


Asp Lys Glu Thr Gly Glu Ile Lys Ser Phe Pro Val Lys Cys Ile Ala 
            420                 425                 430         


Lys Ser His Pro Leu Phe Gln Glu Phe Arg Leu Trp Gln Phe Ile Val 
        435                 440                 445             


Asn Leu Arg Ile Tyr Arg Lys Asp Leu Ala Gln Asp Val Asp Val Thr 
    450                 455                 460                 


Asn Glu Leu Leu Lys Thr Glu Glu Asp Tyr Val Ala Leu Phe Asp Trp 
465                 470                 475                 480 


Leu Asn Gly Lys Lys Glu Ile Asp Gln Lys Ala Phe Leu Lys Tyr Pro 
                485                 490                 495     


Val Phe Gly Leu Lys Lys Glu Ile Glu Asn Tyr Arg Trp Asn Tyr Val 
            500                 505                 510         


Gln Asp Lys Pro Tyr Pro Cys Asn Glu Thr Arg Ser Leu Met Leu Ala 
        515                 520                 525             


Arg Leu Glu Lys Cys Asp Ile Ser Ile Glu Phe Leu Thr Lys Glu Asn 
    530                 535                 540                 


Glu Glu Ala Leu Trp His Ile Leu Tyr Ser Val Glu Asp Lys Asn Glu 
545                 550                 555                 560 


Ile Val Lys Ala Leu Gln Lys Phe Ala Asp Lys His Asp Leu Asn Ala 
                565                 570                 575     


Ser Phe Val Asp Val Phe Gln Lys Phe Pro Pro Phe Lys Lys Glu Tyr 
            580                 585                 590         


Gly Ser Tyr Ser Ala Lys Ala Ile Lys Lys Leu Leu Pro Leu Met Arg 
        595                 600                 605             


Met Gly Lys Tyr Trp Ser Glu Asn Ser Ile Asp Lys Gly Thr Arg Glu 
    610                 615                 620                 


Arg Ile Asp Lys Ile Ile Thr Gly Glu Tyr Asp Glu Lys Ile Glu Asn 
625                 630                 635                 640 


Arg Val Arg Glu Lys Ala Ile His Leu Ala Asp Val Ser Asp Phe Lys 
                645                 650                 655     


Gly Leu Pro Leu Trp Leu Val Cys Tyr Ile Val Tyr Gly Arg His Ser 
            660                 665                 670         


Glu Ala Lys Glu Ile Thr Gln Trp Lys Ser Pro Ala Asp Ile Asp Ser 
        675                 680                 685             


Tyr Leu Arg Ser Phe Lys Gln His Ser Leu Arg Asn Pro Ile Val Glu 
    690                 695                 700                 


Gln Ile Ile Ile Glu Thr Leu Arg Val Val Arg Asp Ile Trp Lys Gln 
705                 710                 715                 720 


Val Gly Asn Ile Asp Glu Ile His Val Glu Leu Gly Arg Glu Met Lys 
                725                 730                 735     


Asn Pro Ala Asp Lys Arg Lys Lys Met Thr Gln Gln Met Ser Glu Asn 
            740                 745                 750         


Glu Asn Thr Asn Leu Arg Ile Lys Tyr Leu Leu Thr Glu Phe Leu Asn 
        755                 760                 765             


Pro Glu Tyr Glu Val Glu Asn Val Arg Pro Tyr Ser Pro Ser Gln Gln 
    770                 775                 780                 


Asp Ile Leu Arg Ile Tyr Glu Glu Gly Val Leu Asn Ser Val Ser Asp 
785                 790                 795                 800 


Leu Pro Glu Glu Ile Ser Asp Ile Leu Lys Lys Phe Thr Glu Thr Asp 
                805                 810                 815     


Leu Lys Lys Arg Pro Ser Arg Ser Glu Ile Leu Arg Tyr Lys Leu Trp 
            820                 825                 830         


Leu Glu Gln Lys Tyr Arg Ser Pro Tyr Thr Gly Glu Val Ile Pro Leu 
        835                 840                 845             


Gly Lys Leu Phe Thr Pro Ala Tyr Glu Ile Glu His Val Ile Pro Gln 
    850                 855                 860                 


Ser Cys Tyr Phe Asp Asp Ser Phe Ser Asn Lys Val Ile Cys Glu Ala 
865                 870                 875                 880 


Glu Val Asn Lys Leu Lys Ser Asn Leu Leu Gly His Glu Phe Ile Val 
                885                 890                 895     


Lys His His Gly Glu Ile Val Glu Leu Pro Phe Gly Lys Lys Val Arg 
            900                 905                 910         


Ile Phe Thr Val Asp Glu Tyr Glu Gln Phe Val Lys Asp Asn Tyr Ser 
        915                 920                 925             


Arg Thr Arg Ser Lys Met Lys Lys Leu Leu Met Asp Asp Ile Pro Glu 
    930                 935                 940                 


Glu Phe Val Thr Arg Gln Leu Asn Asp Ser Arg Tyr Ile Ser Lys Val 
945                 950                 955                 960 


Val Lys Ser Leu Leu Ser Asn Ile Val Arg Glu Lys Gly Glu Glu Glu 
                965                 970                 975     


Ala Ile Ser Lys Asn Val Ile Pro Cys Thr Gly Gly Val Thr Asp Arg 
            980                 985                 990         


Leu Lys Lys Asp Trp Gly Ile Asn  Glu Val Trp Asn Lys  Ile Ile Leu 
        995                 1000                 1005             


Pro Arg  Phe Gln Arg Leu Asn  Glu Leu Thr Gly Thr  Asn Lys Phe 
    1010                 1015                 1020             


Thr Thr  Lys Asn Val Gly Ile  Gln Glu Ile Pro Thr  Met Pro Leu 
    1025                 1030                 1035             


Glu Leu  Gln Lys Gly Phe Asn  Lys Lys Arg Ile Asp  His Arg His 
    1040                 1045                 1050             


His Ala  Met Asp Ala Ile Ile  Ile Ala Cys Ala Asn  Arg Asn Ile 
    1055                 1060                 1065             


Ile Asn  Tyr Leu Asn Asn Glu  Ser Ala Thr Ala Lys  Ala Glu Leu 
    1070                 1075                 1080             


Ser Arg  Tyr Asp Leu Gln Lys  Met Leu Cys Asp Lys  Ala Lys Thr 
    1085                 1090                 1095             


Asp Asn  Asn Gly Asn Tyr Lys  Trp Val Ile Arg Lys  Pro Trp Ala 
    1100                 1105                 1110             


Ser Phe  Thr Gln Asp Thr Tyr  Leu Ala Leu Glu Asn  Ile Ile Val 
    1115                 1120                 1125             


Ser Phe  Lys Gln Asn Leu Arg  Val Ile Asn Lys Ala  Thr Asn Arg 
    1130                 1135                 1140             


Phe Leu  His Tyr Asn Glu Glu  Gly Lys Lys Ile Phe  Val Lys Gln 
    1145                 1150                 1155             


Gly Lys  Gly Asp Asn Trp Ala  Ile Arg Lys Ser Met  His Lys Asp 
    1160                 1165                 1170             


Thr Val  Phe Gly Glu Val Asn  Leu Arg Arg Ile Lys  Thr Val Ala 
    1175                 1180                 1185             


Leu Asn  Glu Ala Met Lys Asn  Pro Gln Ser Ile Val  Val Lys Asp 
    1190                 1195                 1200             


Phe Lys  Arg Lys Leu Leu Glu  Leu Trp Asn Leu Gly  Phe Asp Ala 
    1205                 1210                 1215             


Lys Arg  Ile Lys Lys Tyr Phe  Glu Asp Asn Arg Glu  Thr Trp Ser 
    1220                 1225                 1230             


Asp Ile  Asn Leu Ser Lys Ile  Glu Val Tyr Tyr Phe  Ser Lys Asp 
    1235                 1240                 1245             


Thr Lys  Asp Arg Phe Phe Ala  Thr Arg Lys Pro Leu  Asp Thr Ser 
    1250                 1255                 1260             


Phe Asp  Arg Lys Lys Ile Glu  Asn Asn Ile Thr Asp  Thr Gly Ile 
    1265                 1270                 1275             


Gln Lys  Ile Leu Leu Arg His  Leu Glu Leu Lys Asp  Asn Asn Pro 
    1280                 1285                 1290             


Asp Ile  Ala Phe Ser Pro Asp  Gly Ile Asp Glu Met  Asn Arg Asn 
    1295                 1300                 1305             


Ile Ile  Gln Leu Asn Asn Gly  Lys Tyr His Gln Pro  Ile Ile Lys 
    1310                 1315                 1320             


Ile Arg  Trp Tyr Glu Gln Ala  Asp Lys Phe Ala Val  Gly Gln Thr 
    1325                 1330                 1335             


Gly Asn  Lys Phe Ser Lys Phe  Val Glu Ala Ala Lys  Gly Thr Asn 
    1340                 1345                 1350             


Leu Phe  Phe Ala Val Tyr Glu  Ser Asn Ile Leu Asp  Lys Lys Thr 
    1355                 1360                 1365             


Asn Thr  Ile Ile Lys Lys Arg  Asn Tyr Ala Thr Ile  Pro Leu Asn 
    1370                 1375                 1380             


Val Ala  Ile Glu Arg Gln Lys  Gln Gly Leu Pro Val  Ala Pro Glu 
    1385                 1390                 1395             


Asp Glu  Asn Gly Asn Asp Pro  Ile Phe Val Leu Ser  Pro Asn Asp 
    1400                 1405                 1410             


Leu Val  Tyr Leu Pro Thr Asp  Asp Glu Leu Ala Asn  Gly Ile Ile 
    1415                 1420                 1425             


Ala Gln  Pro Leu Asp Arg Gly  Arg Ile Tyr Lys Met  Val Ser Cys 
    1430                 1435                 1440             


Thr Gly  Asn Glu Gly His Phe  Ile Pro Ala Arg Ile  Ala Asn Pro 
    1445                 1450                 1455             


Ile Leu  Gln Thr Ile Glu Leu  Gly Ser Asn Asn Lys  Ala Gln Lys 
    1460                 1465                 1470             


Ala Trp  Thr Asp Glu Met Ile  Lys Glu Ile Cys Met  Pro Ile Lys 
    1475                 1480                 1485             


Val Asp  Arg Leu Gly Asn Val  Leu Glu Ser Ser Ser  Ser Tyr Lys 
    1490                 1495                 1500             


Lys 
    


<210> 89
<211> 1434
<212> PRT
<213> Unknown


<220>
<223> Description of Unknown: Bacteroidetes oral taxon 274 
      str. F0058 polypeptide

<400> 89
Met Lys Asn Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Tyr Val Lys Gln Ala Gln Asn Asp Ser Glu Lys Ser Glu Ile Ala 
            20                  25                  30          


Glu Leu Gly Val Arg Val Asn Pro Leu Thr Val Asp Glu Lys Thr Asn 
        35                  40                  45              


Phe Glu Lys Gly Lys Pro Ile Ser Thr Asn Ala Asp Arg Thr Leu Lys 
    50                  55                  60                  


Arg Gly Ala Arg Arg Asn Leu Gln Arg Tyr Lys Leu Arg Arg Gln Glu 
65                  70                  75                  80  


Leu Ile Glu Leu Leu Lys Asp Tyr Gln Val Ile Ser Asp Lys Thr Ile 
                85                  90                  95      


Leu Ala Glu Asp Gly Lys Glu Thr Thr Phe Glu Thr Leu Arg Leu Arg 
            100                 105                 110         


Val Lys Ser Ala Lys Glu Gln Val Ser Leu Glu Glu Leu Ala Arg Ile 
        115                 120                 125             


Leu Leu Met Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala 
    130                 135                 140                 


Lys Asn Glu Asp Glu Gly Gln Leu Ile Asp Gly Met Glu Ile Ala Arg 
145                 150                 155                 160 


Arg Leu Tyr Asp Glu Asn Leu Thr Thr Gly Gln Leu Ser Leu Gln Leu 
                165                 170                 175     


Leu Lys Glu Gly Lys Lys Ser Leu Pro Asp Tyr Tyr Arg Ser Asp Leu 
            180                 185                 190         


Gln His Glu Leu Asp Lys Val Trp Asn Phe Gln Lys Gln Phe His Pro 
        195                 200                 205             


Asp Ile Leu Thr Asp Glu Phe Tyr Thr Ser Ile Gln Gly Lys Gly Gln 
    210                 215                 220                 


Lys Ala Thr Arg Glu Ser Phe Ser Ser Lys Tyr Gly Ile Asp Thr Ala 
225                 230                 235                 240 


Glu Asn Lys Gly Ser Arg Glu Glu Lys Lys Leu Gln Ala Tyr Gln Trp 
                245                 250                 255     


Arg Ala Asp Ala Thr His Lys Glu Leu Thr Lys Glu Glu Leu Ala Phe 
            260                 265                 270         


Val Ile Thr Glu Ile Asn Asn Asn Ile Asn Asn Ser Ser Gly Tyr Leu 
        275                 280                 285             


Gly Ala Ile Ser Asp Arg Ser Lys Glu Leu Ile Phe Ala Asn Glu Thr 
    290                 295                 300                 


Val Gly Glu Tyr Leu Trp Lys Gln Ile Gln Asn Asp Pro His Thr Ser 
305                 310                 315                 320 


Leu Lys Asn Gln Val Phe Tyr Arg Gln Asp Tyr Phe Asp Glu Phe Glu 
                325                 330                 335     


Arg Ile Trp Glu Thr Gln Ser Gly Phe Tyr Pro Gln Ile Leu Thr Glu 
            340                 345                 350         


Ser Leu Lys Asn Glu Leu Arg Asp Ile Leu Ile Phe Tyr Gln Arg Lys 
        355                 360                 365             


Leu Lys Ser Gln Lys Ala Leu Val Ser Ile Cys Glu Phe Glu Ser Lys 
    370                 375                 380                 


Glu Ile Pro Leu Lys Asp Lys Gln Gly Asn Pro Ile Ser Lys Asn Gly 
385                 390                 395                 400 


Ile Pro Val Thr Lys Leu Val Gly Pro Lys Val Ala Pro Lys Ser Ser 
                405                 410                 415     


Pro Leu Phe Gln Glu Phe Lys Ile Trp Gln Asn Leu Asn Asn Val Leu 
            420                 425                 430         


Val Arg Pro Lys Gly Ser Arg Lys Arg Lys Val Thr Thr Asn Gln Gln 
        435                 440                 445             


Ser Thr Leu Leu Glu Gly Gln Glu Pro Val Phe Glu Leu Asn Leu Glu 
    450                 455                 460                 


Gln Lys Glu Leu Leu Phe Glu Glu Leu Asn Leu Lys Gly Asn Leu Lys 
465                 470                 475                 480 


Thr Asp Tyr Cys Leu Glu Leu Ile Gly Tyr Ser Ala Lys Glu Trp Glu 
                485                 490                 495     


Met Asn Tyr Pro Thr Leu Glu Gly Asn Lys Thr Asn Lys Ala Leu Tyr 
            500                 505                 510         


Glu Ala Tyr Leu Lys Ile Ile Asp Ser Glu Gly Tyr Asp Ala Lys Lys 
        515                 520                 525             


Leu Leu Lys Val Lys Thr Asp Lys Asp Asp Ile Asn Leu Asp Asp Ile 
    530                 535                 540                 


Lys Val Ser Ala Ser Glu Ile Lys Thr Met Ile Ser Asp Ile Phe Asn 
545                 550                 555                 560 


Glu Leu Gly Ile Asn Thr Lys Ile Leu Asp Phe Asp Ala Glu Leu Glu 
                565                 570                 575     


Arg Lys Gln Phe Glu Ala Gln Ala Ser Tyr Arg Leu Trp His Leu Leu 
            580                 585                 590         


Tyr Ser Tyr Glu Gly Asp Asp Ser Lys Ser Gly Asn Glu Leu Leu Tyr 
        595                 600                 605             


Arg Leu Leu Glu Asp Lys Phe Gly Phe Lys Arg Glu His Ser Lys Thr 
    610                 615                 620                 


Leu Ala Asn Val Ser Leu Leu Ser Asp Tyr Gly Asn Leu Ser Thr Lys 
625                 630                 635                 640 


Ala Ile Arg Thr Ile Tyr Pro Tyr Ile Lys Glu Asn Lys Phe Ser Thr 
                645                 650                 655     


Ala Cys Glu Leu Ala Gly Tyr Arg His Ser Lys Leu Ser Ile Ser Lys 
            660                 665                 670         


Glu Glu Asn Glu Asn Arg Thr Leu Lys Asp Thr Leu Asp Val Leu Lys 
        675                 680                 685             


Lys Asn Ser Leu Arg Gln Pro Val Val Glu Lys Ile Leu Asn Gln Met 
    690                 695                 700                 


Ile Asn Leu Ile Asn Glu Leu Ile Glu Lys His Ser Glu Lys Asp Glu 
705                 710                 715                 720 


Lys Gly Asn Ile Val Lys Tyr Phe Lys Phe Asp Glu Ile His Ile Glu 
                725                 730                 735     


Leu Ala Arg Glu Leu Lys Lys Asn Ala Glu Glu Arg Arg Glu Leu Asp 
            740                 745                 750         


Ser Lys Val Arg Glu Gly Lys Asp Arg Asn Glu Lys Ile Ile Thr Ile 
        755                 760                 765             


Leu Lys Ser Glu Phe Gly Leu Pro Tyr Pro Thr Lys Asn Asp Ile Thr 
    770                 775                 780                 


Arg Tyr Arg Leu Tyr Glu Glu Leu Lys Asp Asn Gly Tyr Lys Asp Leu 
785                 790                 795                 800 


Tyr Thr Asn Thr Tyr Ile Pro Arg Glu Lys Leu Phe Ser Lys Glu Ile 
                805                 810                 815     


Asp Ile Glu His Ile Ile Pro Lys Ser Arg Leu Phe Asn Asp Ser Phe 
            820                 825                 830         


Ser Asn Lys Thr Ile Cys Tyr Arg Gln Asp Asn Leu Asn Lys Gly Glu 
        835                 840                 845             


Arg Thr Ala Tyr Asp Tyr Ile Glu Gly Leu Gly Lys Thr Gln Leu Asp 
    850                 855                 860                 


Glu Tyr Leu Asn Arg Val Glu Asn Leu Tyr Thr Asn Lys Phe Ile Thr 
865                 870                 875                 880 


Lys Ala Lys Tyr Arg Asn Leu Leu Lys Lys Glu Ser Glu Ile Gly Asp 
                885                 890                 895     


Gly Phe Ile Glu Arg Asp Leu Arg Glu Thr Gln Tyr Ile Ala Lys Lys 
            900                 905                 910         


Ala Lys Glu Met Leu Leu Gln Ile Thr Arg His Val Val Ser Thr Thr 
        915                 920                 925             


Gly Ser Ile Thr Asp Arg Leu Arg Asp Asp Trp Glu Leu Val Asn Val 
    930                 935                 940                 


Met Arg Glu Leu Asn Leu Pro Lys Tyr Lys Val Leu Gly Leu Thr Glu 
945                 950                 955                 960 


Ile Gln Glu Arg Lys Asn Gly Gln Thr Val Glu Val Ile Thr Asp Trp 
                965                 970                 975     


Thr Lys Arg Asn Asp His Arg His His Ala Met Asp Ala Leu Thr Val 
            980                 985                 990         


Ala Phe Thr Lys His Ser His Ile  Gln Tyr Leu Asn Phe  Leu Asn Ala 
        995                 1000                 1005             


Arg Lys  Asp Glu Lys His Lys  Glu Tyr Ser Asn Ile  Met Gly Ile 
    1010                 1015                 1020             


Gln Gln  Leu Glu Thr Glu Lys  Thr Thr Asp Lys Asp  Gly Lys Asp 
    1025                 1030                 1035             


Arg Arg  Val Phe Lys Thr Pro  Ile Pro Asn Phe Arg  Gln Val Ala 
    1040                 1045                 1050             


Lys Glu  His Leu Glu Ser Ile  Leu Ile Ser His Lys  Thr Lys Asn 
    1055                 1060                 1065             


Lys Val  Val Thr Arg Ala Thr  Asn Lys Ile Ala Gly  Ser Lys Lys 
    1070                 1075                 1080             


Gln Gln  Glu Thr Leu Ser Pro  Arg Gly Gln Leu His  Lys Glu Thr 
    1085                 1090                 1095             


Val Tyr  Gly Lys Tyr Arg Arg  Tyr Val Gln Lys Glu  Glu Lys Ile 
    1100                 1105                 1110             


Gly Ser  Lys Phe Asp Leu Gln  Thr Ile Glu Arg Val  Ala Asn Pro 
    1115                 1120                 1125             


Leu Tyr  Lys Arg Leu Leu Thr  Lys Arg Leu Glu Glu  Asn Gly Gly 
    1130                 1135                 1140             


Asp Pro  Lys Lys Ala Phe Thr  Gly Lys Asn Ala Leu  Ala Lys Ser 
    1145                 1150                 1155             


Pro Ile  Tyr Leu Asp Glu Thr  Gln Thr Gln Gln Leu  Pro Glu Lys 
    1160                 1165                 1170             


Val Lys  Leu Val Trp Leu Glu  Thr Asp Phe Ser Ile  Arg Lys Asp 
    1175                 1180                 1185             


Ile Thr  Pro Asp Asn Phe Lys  Asp Glu Lys Ser Ile  Asp Lys Val 
    1190                 1195                 1200             


Leu Asp  Glu Gly Ile Lys Arg  Ile Leu Lys Asp Arg  Leu Lys Ser 
    1205                 1210                 1215             


Phe Asp  Gly Asp Ala Lys Arg  Ala Phe Thr Asp Leu  Glu Gln Asn 
    1220                 1225                 1230             


Pro Ile  Trp Leu Asn Lys Glu  Lys Gly Ile Ala Ile  Lys Arg Val 
    1235                 1240                 1245             


Thr Ile  Ser Gly Val Ser Asn  Ala Glu Pro Leu His  Thr Lys Lys 
    1250                 1255                 1260             


Asp His  Leu Gly Asn Glu Ile  Phe Asp Asp Thr Gly  Lys Pro Ile 
    1265                 1270                 1275             


Pro Val  Asp Tyr Val Ser Thr  Gly Asn Asn His His  Ile Ala Ile 
    1280                 1285                 1290             


Tyr Arg  Asp Glu Asn Gly Asn  Leu Gln Glu Lys Ala  Val Ser Phe 
    1295                 1300                 1305             


Phe Glu  Ala Val Thr Arg Ala  Asn Gln Gly Leu Pro  Thr Val Asp 
    1310                 1315                 1320             


Lys Thr  Tyr Asn Gln His Leu  Gly Trp Gln Phe Leu  Phe Thr Met 
    1325                 1330                 1335             


Lys Gln  Asn Glu Met Phe Val  Phe Pro Asn Lys Glu  Thr Gly Phe 
    1340                 1345                 1350             


Asp Pro  Gln Glu Ile Asp Leu  Leu Asp Pro Lys Asn  Lys Lys Leu 
    1355                 1360                 1365             


Ile Ser  Pro Asn Leu Phe Arg  Val Gln Lys Ile Ser  Thr Lys Asn 
    1370                 1375                 1380             


Tyr Phe  Phe Arg His His Leu  Glu Thr Ser Val Glu  Thr His Asn 
    1385                 1390                 1395             


Ala Leu  Asn Gly Val Thr Tyr  Lys Ser Gln Leu Gly  Leu Asn Gly 
    1400                 1405                 1410             


Ile Thr  Asp Ile Ile Lys Val  Arg Ile Asn His Leu  Gly Asp Ile 
    1415                 1420                 1425             


Val His  Ile Gly Glu Tyr 
    1430                 


<210> 90
<211> 1153
<212> PRT
<213> Barnesiella intestinihominis


<220>
<223> Barnesiella intestinihominis YIT 11860

<400> 90
Met Lys Asn Ile Leu Gly Leu Asp Leu Gly Leu Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ser Val Ile Arg Glu Asn Ser Glu Glu Gln Glu Leu Val Ala Met Gly 
            20                  25                  30          


Ser Arg Val Val Ser Leu Thr Ala Ala Glu Leu Ser Ser Phe Thr Gln 
        35                  40                  45              


Gly Asn Gly Val Ser Ile Asn Ser Gln Arg Thr Gln Lys Arg Thr Gln 
    50                  55                  60                  


Arg Lys Gly Tyr Asp Arg Tyr Gln Leu Arg Arg Thr Leu Leu Arg Asn 
65                  70                  75                  80  


Lys Leu Asp Thr Leu Gly Met Leu Pro Asp Asp Ser Leu Ser Tyr Leu 
                85                  90                  95      


Pro Lys Leu Gln Leu Trp Gly Leu Arg Ala Lys Ala Val Thr Gln Arg 
            100                 105                 110         


Ile Glu Leu Asn Glu Leu Gly Arg Val Leu Leu His Leu Asn Gln Lys 
        115                 120                 125             


Arg Gly Tyr Lys Ser Ile Lys Ser Asp Phe Ser Gly Asp Lys Lys Ile 
    130                 135                 140                 


Thr Asp Tyr Val Lys Thr Val Lys Thr Arg Tyr Asp Glu Leu Lys Glu 
145                 150                 155                 160 


Met Arg Leu Thr Ile Gly Glu Leu Phe Phe Arg Arg Leu Thr Glu Asn 
                165                 170                 175     


Ala Phe Phe Arg Cys Lys Glu Gln Val Tyr Pro Arg Gln Ala Tyr Val 
            180                 185                 190         


Glu Glu Phe Asp Cys Ile Met Asn Cys Gln Arg Lys Phe Tyr Pro Asp 
        195                 200                 205             


Ile Leu Thr Asp Glu Thr Ile Arg Cys Ile Arg Asp Glu Ile Ile Tyr 
    210                 215                 220                 


Tyr Gln Arg Pro Leu Lys Ser Cys Lys Tyr Leu Val Ser Arg Cys Glu 
225                 230                 235                 240 


Phe Glu Lys Arg Phe Tyr Leu Asn Ala Ala Gly Lys Lys Thr Glu Ala 
                245                 250                 255     


Gly Pro Lys Val Ser Pro Arg Thr Ser Pro Leu Phe Gln Val Cys Arg 
            260                 265                 270         


Leu Trp Glu Ser Ile Asn Asn Ile Val Val Lys Asp Arg Arg Asn Glu 
        275                 280                 285             


Ile Val Phe Ile Ser Ala Glu Gln Arg Ala Ala Leu Phe Asp Phe Leu 
    290                 295                 300                 


Asn Thr His Glu Lys Leu Lys Gly Ser Asp Leu Leu Lys Leu Leu Gly 
305                 310                 315                 320 


Leu Ser Lys Thr Tyr Gly Tyr Arg Leu Gly Glu Gln Phe Lys Thr Gly 
                325                 330                 335     


Ile Gln Gly Asn Lys Thr Arg Val Glu Ile Glu Arg Ala Leu Gly Asn 
            340                 345                 350         


Tyr Pro Asp Lys Lys Arg Leu Leu Gln Phe Asn Leu Gln Glu Glu Ser 
        355                 360                 365             


Ser Ser Met Val Asn Thr Glu Thr Gly Glu Ile Ile Pro Met Ile Ser 
    370                 375                 380                 


Leu Ser Phe Glu Gln Glu Pro Leu Tyr Arg Leu Trp His Val Leu Tyr 
385                 390                 395                 400 


Ser Ile Asp Asp Arg Glu Gln Leu Gln Ser Val Leu Arg Gln Lys Phe 
                405                 410                 415     


Gly Ile Asp Asp Asp Glu Val Leu Glu Arg Leu Ser Ala Ile Asp Leu 
            420                 425                 430         


Val Lys Ala Gly Phe Gly Asn Lys Ser Ser Lys Ala Ile Arg Arg Ile 
        435                 440                 445             


Leu Pro Phe Leu Gln Leu Gly Met Asn Tyr Ala Glu Ala Cys Glu Ala 
    450                 455                 460                 


Ala Gly Tyr Asn His Ser Asn Asn Tyr Thr Lys Ala Glu Asn Glu Ala 
465                 470                 475                 480 


Arg Ala Leu Leu Asp Arg Leu Pro Ala Ile Lys Lys Asn Glu Leu Arg 
                485                 490                 495     


Gln Pro Val Val Glu Lys Ile Leu Asn Gln Met Val Asn Val Val Asn 
            500                 505                 510         


Ala Leu Met Glu Lys Tyr Gly Arg Phe Asp Glu Ile Arg Val Glu Leu 
        515                 520                 525             


Ala Arg Glu Leu Lys Gln Ser Lys Glu Glu Arg Ser Asn Thr Tyr Lys 
    530                 535                 540                 


Ser Ile Asn Lys Asn Gln Arg Glu Asn Glu Gln Ile Ala Lys Arg Ile 
545                 550                 555                 560 


Val Glu Tyr Gly Val Pro Thr Arg Ser Arg Ile Gln Lys Tyr Lys Met 
                565                 570                 575     


Trp Glu Glu Ser Lys His Cys Cys Ile Tyr Cys Gly Gln Pro Val Asp 
            580                 585                 590         


Val Gly Asp Phe Leu Arg Gly Phe Asp Val Glu Val Glu His Ile Ile 
        595                 600                 605             


Pro Lys Ser Leu Tyr Phe Asp Asp Ser Phe Ala Asn Lys Val Cys Ser 
    610                 615                 620                 


Cys Arg Ser Cys Asn Lys Glu Lys Asn Asn Arg Thr Ala Tyr Asp Tyr 
625                 630                 635                 640 


Met Lys Ser Lys Gly Glu Lys Ala Leu Ser Asp Tyr Val Glu Arg Val 
                645                 650                 655     


Asn Thr Met Tyr Thr Asn Asn Gln Ile Ser Lys Thr Lys Trp Gln Asn 
            660                 665                 670         


Leu Leu Thr Pro Val Asp Lys Ile Ser Ile Asp Phe Ile Asp Arg Gln 
        675                 680                 685             


Leu Arg Glu Ser Gln Tyr Ile Ala Arg Lys Ala Lys Glu Ile Leu Thr 
    690                 695                 700                 


Ser Ile Cys Tyr Asn Val Thr Ala Thr Ser Gly Ser Val Thr Ser Phe 
705                 710                 715                 720 


Leu Arg His Val Trp Gly Trp Asp Thr Val Leu His Asp Leu Asn Phe 
                725                 730                 735     


Asp Arg Tyr Lys Lys Val Gly Leu Thr Glu Val Ile Glu Val Asn His 
            740                 745                 750         


Arg Gly Ser Val Ile Arg Arg Glu Gln Ile Lys Asp Trp Ser Lys Arg 
        755                 760                 765             


Phe Asp His Arg His His Ala Ile Asp Ala Leu Thr Ile Ala Cys Thr 
    770                 775                 780                 


Lys Gln Ala Tyr Ile Gln Arg Leu Asn Asn Leu Arg Ala Glu Glu Gly 
785                 790                 795                 800 


Pro Asp Phe Asn Lys Met Ser Leu Glu Arg Tyr Ile Gln Ser Gln Pro 
                805                 810                 815     


His Phe Ser Val Ala Gln Val Arg Glu Ala Val Asp Arg Ile Leu Val 
            820                 825                 830         


Ser Phe Arg Ala Gly Lys Arg Ala Val Thr Pro Gly Lys Arg Tyr Ile 
        835                 840                 845             


Arg Lys Asn Arg Lys Arg Ile Ser Val Gln Ser Val Leu Ile Pro Arg 
    850                 855                 860                 


Gly Ala Leu Ser Glu Glu Ser Val Tyr Gly Val Ile His Val Trp Glu 
865                 870                 875                 880 


Lys Asp Glu Gln Gly His Val Ile Gln Lys Gln Arg Ala Val Met Lys 
                885                 890                 895     


Tyr Pro Ile Thr Ser Ile Asn Arg Glu Met Leu Asp Lys Glu Lys Val 
            900                 905                 910         


Val Asp Lys Arg Ile His Arg Ile Leu Ser Gly Arg Leu Ala Gln Tyr 
        915                 920                 925             


Asn Asp Asn Pro Lys Glu Ala Phe Ala Lys Pro Val Tyr Ile Asp Lys 
    930                 935                 940                 


Glu Cys Arg Ile Pro Ile Arg Thr Val Arg Cys Phe Ala Lys Pro Ala 
945                 950                 955                 960 


Ile Asn Thr Leu Val Pro Leu Lys Lys Asp Asp Lys Gly Asn Pro Val 
                965                 970                 975     


Ala Trp Val Asn Pro Gly Asn Asn His His Val Ala Ile Tyr Arg Asp 
            980                 985                 990         


Glu Asp Gly Lys Tyr Lys Glu Arg  Thr Val Thr Phe Trp  Glu Ala Val 
        995                 1000                 1005             


Asp Arg  Cys Arg Val Gly Ile  Pro Ala Ile Val Thr  Gln Pro Asp 
    1010                 1015                 1020             


Thr Ile  Trp Asp Asn Ile Leu  Gln Arg Asn Asp Ile  Ser Glu Asn 
    1025                 1030                 1035             


Val Leu  Glu Ser Leu Pro Asp  Val Lys Trp Gln Phe  Val Leu Ser 
    1040                 1045                 1050             


Leu Gln  Gln Asn Glu Met Phe  Ile Leu Gly Met Asn  Glu Glu Asp 
    1055                 1060                 1065             


Tyr Arg  Tyr Ala Met Asp Gln  Gln Asp Tyr Ala Leu  Leu Asn Lys 
    1070                 1075                 1080             


Tyr Leu  Tyr Arg Val Gln Lys  Leu Ser Lys Ser Asp  Tyr Ser Phe 
    1085                 1090                 1095             


Arg Tyr  His Thr Glu Thr Ser  Val Glu Asp Lys Tyr  Asp Gly Lys 
    1100                 1105                 1110             


Pro Asn  Leu Lys Leu Ser Met  Gln Met Gly Lys Leu  Lys Arg Val 
    1115                 1120                 1125             


Ser Ile  Lys Ser Leu Leu Gly  Leu Asn Pro His Lys  Val His Ile 
    1130                 1135                 1140             


Ser Val  Leu Gly Glu Ile Lys  Glu Ile Ser 
    1145                 1150             


<210> 91
<211> 1352
<212> PRT
<213> Belliella baltica

<400> 91
Met Lys Lys Ile Leu Gly Leu Asp Leu Gly Thr Thr Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ile Lys Glu Pro Glu Lys Asp Val Val Gly Ser Glu Ile Val 
            20                  25                  30          


Asp Met Gly Val Arg Ile Val Pro Leu Ser Ser Asp Glu Glu Asn Asp 
        35                  40                  45              


Phe Ala Lys Gly Asn Thr Ile Ser Ile Asn Ala Asp Arg Thr Leu Lys 
    50                  55                  60                  


Arg Gly Ala Arg Arg Asn Leu Gln Arg Phe Lys Gln Arg Arg Asn Ala 
65                  70                  75                  80  


Leu Leu Glu Ile Phe Lys Glu Lys Lys Leu Ile Ser Thr Asn Phe Lys 
                85                  90                  95      


Tyr Ala Glu Asp Gly Pro Ser Ser Thr Phe Ser Thr Leu Asn Leu Arg 
            100                 105                 110         


Ala Lys Ala Ala Lys Glu Lys Ile Glu Leu Gln Asp Leu Val Lys Val 
        115                 120                 125             


Leu Leu Gln Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala 
    130                 135                 140                 


Lys Ser Glu Glu Asp Asp Gly Ser Ala Ile Asp Ser Met Gly Ile Ala 
145                 150                 155                 160 


Lys Glu Leu Tyr Glu Asn Asp Leu Thr Pro Gly Gln Trp Val Tyr Glu 
                165                 170                 175     


Ala Leu Gln Lys Gly Arg Lys Asn Val Pro Asp Phe Tyr Arg Ser Asp 
            180                 185                 190         


Leu Gln Glu Glu Phe Lys Lys Ile Val Asn Tyr Gln Ser Glu Phe Phe 
        195                 200                 205             


Pro Asp Ile Phe Asn Ala Ser Phe Val Glu Asp Trp Met Gly Lys Ala 
    210                 215                 220                 


Ser Thr Pro Thr Lys Gln Tyr Phe Asn Lys Lys Gly Val Gln Leu Ala 
225                 230                 235                 240 


Glu Asn Lys Gly Lys Arg Glu Glu Arg Arg Leu Gln Glu Tyr Lys Trp 
                245                 250                 255     


Arg Ala Glu Ala Val Asn Phe Lys Ile Asp Leu Ser Glu Ile Ala Leu 
            260                 265                 270         


Ile Leu Ser Gln Ile Asn Ser Gln Ile Ser Asn Ser Ser Gly Tyr Leu 
        275                 280                 285             


Gly Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Lys Asn Leu Thr 
    290                 295                 300                 


Val Gly Gln Tyr Leu Tyr Gln Gln Ile Lys Lys Asn Pro His Thr Arg 
305                 310                 315                 320 


Leu Lys Gly Gln Val Phe Tyr Arg Gln Asp Tyr Leu Asp Glu Phe Glu 
                325                 330                 335     


Arg Ile Trp Ser Val Gln Ser Ser Phe Tyr Pro Gln Leu Asn Asp Ala 
            340                 345                 350         


Leu Lys Arg Glu Val Arg Asp Ile Thr Ile Phe Phe Gln Arg Arg Leu 
        355                 360                 365             


Lys Ser Gln Lys His Leu Ile Ser Asn Cys Glu Phe Glu Asp His His 
    370                 375                 380                 


Lys Val Val Pro Lys Ser His Pro Val Phe Gln Glu Phe Arg Ile Trp 
385                 390                 395                 400 


Gln Asn Leu Asn Asn Leu Leu Leu Ile Lys Lys Asp Asn Leu Asn Glu 
                405                 410                 415     


Lys Phe Asp Leu Glu Leu Glu Ser Lys Ile Ala Leu Ala Asn Glu Leu 
            420                 425                 430         


Ala Phe Lys Arg Glu Leu Asn Val Lys Asp Ala Leu Lys Ile Leu Gly 
        435                 440                 445             


Leu Lys Pro Asn Glu Trp Glu Phe Asn Phe Thr Lys Ile Glu Gly Asn 
    450                 455                 460                 


Arg Thr Asn Gln Ala Phe Phe Asp Ala Phe Ala Lys Ile Ile Glu Leu 
465                 470                 475                 480 


Glu Asp Gly Glu Pro Ile Asp Leu Gly Asp Leu Lys Ala Asp Asp Ile 
                485                 490                 495     


Leu Asp Gln Phe Ser Glu Ala Phe Leu Arg Ile Gly Ile Asp Thr Glu 
            500                 505                 510         


Leu Leu Gln Val Asn Ser Asp Ile Glu Gly Ala Glu Tyr Glu Lys Gln 
        515                 520                 525             


Ser Tyr Ile Gln Phe Trp His Leu Leu Tyr Ser Ser Glu Asp Asp Gln 
    530                 535                 540                 


Lys Leu Lys Leu Asn Leu Ile Arg Lys Phe Gly Phe Lys Pro Glu His 
545                 550                 555                 560 


Ala Lys Ile Leu Ala Ser Ile Ser Leu Gln Asp Asp His Ala Ser Leu 
                565                 570                 575     


Ser Ser Arg Ala Ile Lys Lys Ile Leu Pro His Leu Gln Ser Gly Leu 
            580                 585                 590         


Ile Tyr Asp Lys Ala Cys Thr Tyr Ala Gly Tyr Asn His Ser Ser Ser 
        595                 600                 605             


Phe Thr Lys Asp Glu Asn Glu Lys Arg Glu Leu Arg Ala Glu Leu Glu 
    610                 615                 620                 


Leu Leu Lys Lys Asn Ser Leu Arg Asn Pro Val Val Glu Lys Ile Leu 
625                 630                 635                 640 


Asn Gln Met Ile Asn Val Val Asn Ala Ile Leu Lys Asp Pro Glu Leu 
                645                 650                 655     


Gly Arg Pro Asp Glu Ile Arg Val Glu Met Ala Arg Glu Leu Lys Ala 
            660                 665                 670         


Asn Ala Glu Gln Arg Lys Asn Met Thr Ser Asn Ile Ala Ser Ala Thr 
        675                 680                 685             


Arg Asp His Asp Lys Tyr Arg Glu Ile Leu Lys Ser Glu Phe Gly Leu 
    690                 695                 700                 


Lys Arg Val Thr Lys Asn Asp Leu Leu Arg Tyr Lys Leu Trp Leu Glu 
705                 710                 715                 720 


Thr Asp Gly Ile Ser Leu Tyr Thr Gly Lys Pro Ile Glu Ala Ser Lys 
                725                 730                 735     


Leu Phe Ser Lys Glu Tyr Asp Ile Glu His Ile Ile Pro Lys Ala Arg 
            740                 745                 750         


Leu Phe Asp Asp Ser Phe Ser Asn Lys Thr Ile Cys Glu Arg Gln Leu 
        755                 760                 765             


Asn Ile Asp Lys Ala Asn Val Thr Ala Phe Ser Phe Leu Gln Asn Lys 
    770                 775                 780                 


Leu Ser Ala Asp Glu Phe Glu Gln Tyr Gln Ser Arg Val Lys Ser Leu 
785                 790                 795                 800 


Tyr Gly Lys Leu Ser Lys Ala Lys Ile Gln Lys Leu Leu Met Ala Asn 
                805                 810                 815     


Asp Lys Ile Pro Glu Asp Phe Ile Ala Arg Gln Leu Gln Glu Thr Arg 
            820                 825                 830         


Tyr Ile Ser Lys Lys Ala Lys Glu Ile Leu Phe Glu Ile Ser Arg Arg 
        835                 840                 845             


Val Ser Val Thr Thr Gly Thr Ile Thr Asp Lys Leu Arg Glu Asp Trp 
    850                 855                 860                 


Gly Leu Val Glu Ile Met Lys Glu Leu Asn Trp Glu Lys Tyr Asp Lys 
865                 870                 875                 880 


Leu Gly Leu Thr Tyr Thr Ile Glu Gly Lys His Gly Glu Arg Leu Asn 
                885                 890                 895     


Lys Ile Lys Asp Trp Ser Lys Arg Asn Asp His Arg His His Ala Met 
            900                 905                 910         


Asp Ala Leu Thr Val Ala Leu Thr Lys Pro Ala Tyr Ile Gln Tyr Leu 
        915                 920                 925             


Asn Asn Leu Asn Ala Lys Gly Leu Asn Asn Lys Lys Gly Thr Glu Val 
    930                 935                 940                 


Phe Ala Ile Glu Gln Lys Tyr Leu Lys Arg Glu Asn Gly Lys Leu Cys 
945                 950                 955                 960 


Phe Ile Pro Pro Ile Glu Asn Ile Arg Ser Glu Ala Lys Lys His Leu 
                965                 970                 975     


Ser Arg Ile Leu Val Ser Tyr Lys Ala Lys Asn Lys Val Val Thr Ile 
            980                 985                 990         


Asn Lys Asn Lys Thr Lys Ser Lys  Ala Gly Leu Asn Glu  Gln Ile Ala 
        995                 1000                 1005             


Leu Thr  Pro Arg Gly Gln Leu  His Lys Glu Thr Val  Tyr Gly Lys 
    1010                 1015                 1020             


Ser Phe  His Tyr Ser Thr Lys  Phe Glu Lys Ile Gly  Ala Ser Phe 
    1025                 1030                 1035             


Asn Val  Gln Lys Ile Asn Thr  Val Ala Lys Lys Glu  Glu Arg Glu 
    1040                 1045                 1050             


Ala Leu  Leu Lys Arg Leu Ala  Glu Asn Gly Asn Asp  Pro Lys Lys 
    1055                 1060                 1065             


Ala Phe  Thr Gly Lys Asn Thr  Leu Asn Lys Met Pro  Ile Tyr Leu 
    1070                 1075                 1080             


Asp Leu  Gly Lys Asn Ile Lys  Leu Ser Glu Lys Val  Lys Thr Val 
    1085                 1090                 1095             


Val Leu  Glu Gln Asn Tyr Thr  Ile Arg Lys Asn Ile  Asp Pro Asp 
    1100                 1105                 1110             


Leu Lys  Val Asp Lys Val Ile  Asp Val Gly Ile Lys  Arg Ile Leu 
    1115                 1120                 1125             


Glu Ser  Arg Leu Glu Glu Phe  Gly Gly Asn Ala Lys  Leu Ala Phe 
    1130                 1135                 1140             


Ser Asn  Leu Glu Glu Asn Pro  Ile Trp Leu Asn Lys  Glu Lys Gly 
    1145                 1150                 1155             


Ile Ser  Ile Lys Arg Val Lys  Ile Ser Gly Val Ser  Asn Val Glu 
    1160                 1165                 1170             


Ser Leu  His Val Lys Lys Asp  His Phe Gly Glu Pro  Ile Leu Asp 
    1175                 1180                 1185             


Gln Glu  Gly Asn Glu Ile Pro  Val Asp Phe Val Ser  Thr Gly Asn 
    1190                 1195                 1200             


Asn His  His Val Ala Ile Tyr  Glu Asp Glu Asn Gly  Asn Leu Gln 
    1205                 1210                 1215             


Glu Glu  Val Val Ser Phe Phe  Glu Ala Val Val Arg  Gln Asn Gln 
    1220                 1225                 1230             


Gly Leu  Pro Ile Ile Lys Lys  Asn His Thr Leu Gly  Trp Lys Phe 
    1235                 1240                 1245             


Leu Phe  Thr Leu Lys Gln Asn  Glu Tyr Phe Val Phe  Pro Ser Asp 
    1250                 1255                 1260             


Asp Phe  Val Pro Ala Asp Val  Asp Leu Met Asp Glu  Gln Asn Tyr 
    1265                 1270                 1275             


His Leu  Ile Ser Pro Asn Leu  Phe Arg Val Gln Lys  Ile Ala Arg 
    1280                 1285                 1290             


Lys Asn  Tyr Val Phe Asn Asn  His Leu Glu Thr Lys  Ala Val Asp 
    1295                 1300                 1305             


Asn Asp  Leu Leu Lys Ser Lys  Lys Glu Leu Ser Lys  Ile Thr Tyr 
    1310                 1315                 1320             


His Phe  Tyr Gln Thr Pro Glu  His Leu Arg Gly Ile  Ile Lys Ile 
    1325                 1330                 1335             


Arg Ile  Asn His Leu Gly Lys  Ile Ile Gln Ile Gly  Glu Tyr 
    1340                 1345                 1350         


<210> 92
<211> 1415
<212> PRT
<213> Bergeyella zoohelcum


<220>
<223> Bergeyella zoohelcum ATCC 43767

<400> 92
Met Lys His Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Ile Glu Arg Asn Ile Glu Glu Lys Tyr Gly Lys Ile Ile Gly 
            20                  25                  30          


Met Gly Ser Arg Ile Val Pro Met Gly Ala Glu Leu Ser Lys Phe Glu 
        35                  40                  45              


Gln Gly Gln Ala Gln Thr Lys Asn Ala Asp Arg Arg Thr Asn Arg Gly 
    50                  55                  60                  


Ala Arg Arg Leu Asn Lys Arg Tyr Lys Gln Arg Arg Asn Lys Leu Ile 
65                  70                  75                  80  


Tyr Ile Leu Gln Lys Leu Asp Met Leu Pro Ser Gln Ile Lys Leu Lys 
                85                  90                  95      


Glu Asp Phe Ser Asp Pro Asn Lys Ile Asp Lys Ile Thr Ile Leu Pro 
            100                 105                 110         


Ile Ser Lys Lys Gln Glu Gln Leu Thr Ala Phe Asp Leu Val Ser Leu 
        115                 120                 125             


Arg Val Lys Ala Leu Thr Glu Lys Val Gly Leu Glu Asp Leu Gly Lys 
    130                 135                 140                 


Ile Ile Tyr Lys Tyr Asn Gln Leu Arg Gly Tyr Ala Gly Gly Ser Leu 
145                 150                 155                 160 


Glu Pro Glu Lys Glu Asp Ile Phe Asp Glu Glu Gln Ser Lys Asp Lys 
                165                 170                 175     


Lys Asn Lys Ser Phe Ile Ala Phe Ser Lys Ile Val Phe Leu Gly Glu 
            180                 185                 190         


Pro Gln Glu Glu Ile Phe Lys Asn Lys Lys Leu Asn Arg Arg Ala Ile 
        195                 200                 205             


Ile Val Glu Thr Glu Glu Gly Asn Phe Glu Gly Ser Thr Phe Leu Glu 
    210                 215                 220                 


Asn Ile Lys Val Gly Asp Ser Leu Glu Leu Leu Ile Asn Ile Ser Ala 
225                 230                 235                 240 


Ser Lys Ser Gly Asp Thr Ile Thr Ile Lys Leu Pro Asn Lys Thr Asn 
                245                 250                 255     


Trp Arg Lys Lys Met Glu Asn Ile Glu Asn Gln Leu Lys Glu Lys Ser 
            260                 265                 270         


Lys Glu Met Gly Arg Glu Phe Tyr Ile Ser Glu Phe Leu Leu Glu Leu 
        275                 280                 285             


Leu Lys Glu Asn Arg Trp Ala Lys Ile Arg Asn Asn Thr Ile Leu Arg 
    290                 295                 300                 


Ala Arg Tyr Glu Ser Glu Phe Glu Ala Ile Trp Asn Glu Gln Val Lys 
305                 310                 315                 320 


His Tyr Pro Phe Leu Glu Asn Leu Asp Lys Lys Thr Leu Ile Glu Ile 
                325                 330                 335     


Val Ser Phe Ile Phe Pro Gly Glu Lys Glu Ser Gln Lys Lys Tyr Arg 
            340                 345                 350         


Glu Leu Gly Leu Glu Lys Gly Leu Lys Tyr Ile Ile Lys Asn Gln Val 
        355                 360                 365             


Val Phe Tyr Gln Arg Glu Leu Lys Asp Gln Ser His Leu Ile Ser Asp 
    370                 375                 380                 


Cys Arg Tyr Glu Pro Asn Glu Lys Ala Ile Ala Lys Ser His Pro Val 
385                 390                 395                 400 


Phe Gln Glu Tyr Lys Val Trp Glu Gln Ile Asn Lys Leu Ile Val Asn 
                405                 410                 415     


Thr Lys Ile Glu Ala Gly Thr Asn Arg Lys Gly Glu Lys Lys Tyr Lys 
            420                 425                 430         


Tyr Ile Asp Arg Pro Ile Pro Thr Ala Leu Lys Glu Trp Ile Phe Glu 
        435                 440                 445             


Glu Leu Gln Asn Lys Lys Glu Ile Thr Phe Ser Ala Ile Phe Lys Lys 
    450                 455                 460                 


Leu Lys Ala Glu Phe Asp Leu Arg Glu Gly Ile Asp Phe Leu Asn Gly 
465                 470                 475                 480 


Met Ser Pro Lys Asp Lys Leu Lys Gly Asn Glu Thr Lys Leu Gln Leu 
                485                 490                 495     


Gln Lys Ser Leu Gly Glu Leu Trp Asp Val Leu Gly Leu Asp Ser Ile 
            500                 505                 510         


Asn Arg Gln Ile Glu Leu Trp Asn Ile Leu Tyr Asn Glu Lys Gly Asn 
        515                 520                 525             


Glu Tyr Asp Leu Thr Ser Asp Arg Thr Ser Lys Val Leu Glu Phe Ile 
    530                 535                 540                 


Asn Lys Tyr Gly Asn Asn Ile Val Asp Asp Asn Ala Glu Glu Thr Ala 
545                 550                 555                 560 


Ile Arg Ile Ser Lys Ile Lys Phe Ala Arg Ala Tyr Ser Ser Leu Ser 
                565                 570                 575     


Leu Lys Ala Val Glu Arg Ile Leu Pro Leu Val Arg Ala Gly Lys Tyr 
            580                 585                 590         


Phe Asn Asn Asp Phe Ser Gln Gln Leu Gln Ser Lys Ile Leu Lys Leu 
        595                 600                 605             


Leu Asn Glu Asn Val Glu Asp Pro Phe Ala Lys Ala Ala Gln Thr Tyr 
    610                 615                 620                 


Leu Asp Asn Asn Gln Ser Val Leu Ser Glu Gly Gly Val Gly Asn Ser 
625                 630                 635                 640 


Ile Ala Thr Ile Leu Val Tyr Asp Lys His Thr Ala Lys Glu Tyr Ser 
                645                 650                 655     


His Asp Glu Leu Tyr Lys Ser Tyr Lys Glu Ile Asn Leu Leu Lys Gln 
            660                 665                 670         


Gly Asp Leu Arg Asn Pro Leu Val Glu Gln Ile Ile Asn Glu Ala Leu 
        675                 680                 685             


Val Leu Ile Arg Asp Ile Trp Lys Asn Tyr Gly Ile Lys Pro Asn Glu 
    690                 695                 700                 


Ile Arg Val Glu Leu Ala Arg Asp Leu Lys Asn Ser Ala Lys Glu Arg 
705                 710                 715                 720 


Ala Thr Ile His Lys Arg Asn Lys Asp Asn Gln Thr Ile Asn Asn Lys 
                725                 730                 735     


Ile Lys Glu Thr Leu Val Lys Asn Lys Lys Glu Leu Ser Leu Ala Asn 
            740                 745                 750         


Ile Glu Lys Val Lys Leu Trp Glu Ala Gln Arg His Leu Ser Pro Tyr 
        755                 760                 765             


Thr Gly Gln Pro Ile Pro Leu Ser Asp Leu Phe Asp Lys Glu Lys Tyr 
    770                 775                 780                 


Asp Val Asp His Ile Ile Pro Ile Ser Arg Tyr Phe Asp Asp Ser Phe 
785                 790                 795                 800 


Thr Asn Lys Val Ile Ser Glu Lys Ser Val Asn Gln Glu Lys Ala Asn 
                805                 810                 815     


Arg Thr Ala Met Glu Tyr Phe Glu Val Gly Ser Leu Lys Tyr Ser Ile 
            820                 825                 830         


Phe Thr Lys Glu Gln Phe Ile Ala His Val Asn Glu Tyr Phe Ser Gly 
        835                 840                 845             


Val Lys Arg Lys Asn Leu Leu Ala Thr Ser Ile Pro Glu Asp Pro Val 
    850                 855                 860                 


Gln Arg Gln Ile Lys Asp Thr Gln Tyr Ile Ala Ile Arg Val Lys Glu 
865                 870                 875                 880 


Glu Leu Asn Lys Ile Val Gly Asn Glu Asn Val Lys Thr Thr Thr Gly 
                885                 890                 895     


Ser Ile Thr Asp Tyr Leu Arg Asn His Trp Gly Leu Thr Asp Lys Phe 
            900                 905                 910         


Lys Leu Leu Leu Lys Glu Arg Tyr Glu Ala Leu Leu Glu Ser Glu Lys 
        915                 920                 925             


Phe Leu Glu Ala Glu Tyr Asp Asn Tyr Lys Lys Asp Phe Asp Ser Arg 
    930                 935                 940                 


Lys Lys Glu Tyr Glu Glu Lys Glu Val Leu Phe Glu Glu Gln Glu Leu 
945                 950                 955                 960 


Thr Arg Glu Glu Phe Ile Lys Glu Tyr Lys Glu Asn Tyr Ile Arg Tyr 
                965                 970                 975     


Lys Lys Asn Lys Leu Ile Ile Lys Gly Trp Ser Lys Arg Ile Asp His 
            980                 985                 990         


Arg His His Ala Ile Asp Ala Leu  Ile Val Ala Cys Thr  Glu Pro Ala 
        995                 1000                 1005             


His Ile  Lys Arg Leu Asn Asp  Leu Asn Lys Val Leu  Gln Asp Trp 
    1010                 1015                 1020             


Leu Val  Glu His Lys Ser Glu  Phe Met Pro Asn Phe  Glu Gly Ser 
    1025                 1030                 1035             


Asn Ser  Glu Leu Leu Glu Glu  Ile Leu Ser Leu Pro  Glu Asn Glu 
    1040                 1045                 1050             


Arg Thr  Glu Ile Phe Thr Gln  Ile Glu Lys Phe Arg  Ala Ile Glu 
    1055                 1060                 1065             


Met Pro  Trp Lys Gly Phe Pro  Glu Gln Val Glu Gln  Lys Leu Lys 
    1070                 1075                 1080             


Glu Ile  Ile Ile Ser His Lys  Pro Lys Asp Lys Leu  Leu Leu Gln 
    1085                 1090                 1095             


Tyr Asn  Lys Ala Gly Asp Arg  Gln Ile Lys Leu Arg  Gly Gln Leu 
    1100                 1105                 1110             


His Glu  Gly Thr Leu Tyr Gly  Ile Ser Gln Gly Lys  Glu Ala Tyr 
    1115                 1120                 1125             


Arg Ile  Pro Leu Thr Lys Phe  Gly Gly Ser Lys Phe  Ala Thr Glu 
    1130                 1135                 1140             


Lys Asn  Ile Gln Lys Ile Val  Ser Pro Phe Leu Ser  Gly Phe Ile 
    1145                 1150                 1155             


Ala Asn  His Leu Lys Glu Tyr  Asn Asn Lys Lys Glu  Glu Ala Phe 
    1160                 1165                 1170             


Ser Ala  Glu Gly Ile Met Asp  Leu Asn Asn Lys Leu  Ala Gln Tyr 
    1175                 1180                 1185             


Arg Asn  Glu Lys Gly Glu Leu  Lys Pro His Thr Pro  Ile Ser Thr 
    1190                 1195                 1200             


Val Lys  Ile Tyr Tyr Lys Asp  Pro Ser Lys Asn Lys  Lys Lys Lys 
    1205                 1210                 1215             


Asp Glu  Glu Asp Leu Ser Leu  Gln Lys Leu Asp Arg  Glu Lys Ala 
    1220                 1225                 1230             


Phe Asn  Glu Lys Leu Tyr Val  Lys Thr Gly Asp Asn  Tyr Leu Phe 
    1235                 1240                 1245             


Ala Val  Leu Glu Gly Glu Ile  Lys Thr Lys Lys Thr  Ser Gln Ile 
    1250                 1255                 1260             


Lys Arg  Leu Tyr Asp Ile Ile  Ser Phe Phe Asp Ala  Thr Asn Phe 
    1265                 1270                 1275             


Leu Lys  Glu Glu Phe Arg Asn  Ala Pro Asp Lys Lys  Thr Phe Asp 
    1280                 1285                 1290             


Lys Asp  Leu Leu Phe Arg Gln  Tyr Phe Glu Glu Arg  Asn Lys Ala 
    1295                 1300                 1305             


Lys Leu  Leu Phe Thr Leu Lys  Gln Gly Asp Phe Val  Tyr Leu Pro 
    1310                 1315                 1320             


Asn Glu  Asn Glu Glu Val Ile  Leu Asp Lys Glu Ser  Pro Leu Tyr 
    1325                 1330                 1335             


Asn Gln  Tyr Trp Gly Asp Leu  Lys Glu Arg Gly Lys  Asn Ile Tyr 
    1340                 1345                 1350             


Val Val  Gln Lys Phe Ser Lys  Lys Gln Ile Tyr Phe  Ile Lys His 
    1355                 1360                 1365             


Thr Ile  Ala Asp Ile Ile Lys  Lys Asp Val Glu Phe  Gly Ser Gln 
    1370                 1375                 1380             


Asn Cys  Tyr Glu Thr Val Glu  Gly Arg Ser Ile Lys  Glu Asn Cys 
    1385                 1390                 1395             


Phe Lys  Leu Glu Ile Asp Arg  Leu Gly Asn Ile Val  Lys Val Ile 
    1400                 1405                 1410             


Lys Arg  
    1415 


<210> 93
<211> 1430
<212> PRT
<213> Bergeyella zoohelcum


<220>
<223> Bergeyella zoohelcum CCUG 30536

<400> 93
Met Lys His Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Val Val Lys Glu Ala Gln Asn Asp Asn Glu Gln Ser Glu Ile Val 
            20                  25                  30          


Asp Val Gly Val Arg Val Asn Pro Leu Thr Thr Asp Glu Lys Thr Asn 
        35                  40                  45              


Phe Glu Lys Gly Lys Pro Ile Ser Thr Asn Ala Asp Arg Thr Leu Lys 
    50                  55                  60                  


Arg Ser Ala Arg Arg Asn Leu Gln Arg Tyr Lys Leu Arg Arg Lys Glu 
65                  70                  75                  80  


Leu Ile Glu Leu Leu Lys Glu His Gln Leu Ile Ser Thr Asp Thr Ile 
                85                  90                  95      


Leu Thr Glu Asn Gly Lys Gly Thr Thr Phe Gln Thr Leu Glu Leu Arg 
            100                 105                 110         


Ala Lys Ser Ala Lys Glu Lys Ile Ser Leu Glu Glu Leu Ala Arg Val 
        115                 120                 125             


Phe Leu Thr Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala 
    130                 135                 140                 


Lys Asn Glu Asp Glu Gly Gln Leu Ile Asp Gly Met Glu Ile Ala Lys 
145                 150                 155                 160 


Arg Leu Tyr Glu Glu Asn Leu Thr Thr Gly Gln Leu Ser Leu Gln Leu 
                165                 170                 175     


Leu Lys Glu Gly Lys Lys Ser Leu Pro Asp Tyr Tyr Arg Ser Asp Leu 
            180                 185                 190         


Gln Phe Glu Leu Asp Lys Val Trp Asn Phe Gln Lys Gln Phe His Ser 
        195                 200                 205             


Asp Ile Leu Thr Asp Glu Phe Tyr Ala Gln Leu Lys Gly Lys Gly Gln 
    210                 215                 220                 


Arg Ala Thr Ser Ala Leu Phe Leu Ala Lys Tyr Gln Ile Tyr Thr Ala 
225                 230                 235                 240 


Glu Asn Lys Gly Ser Arg Glu Asp Lys Lys Leu Gln Ala Tyr Gln Trp 
                245                 250                 255     


Arg Val Asp Ala Leu Ser Lys Glu Leu Thr Arg Glu Gln Leu Ala Phe 
            260                 265                 270         


Val Ile Thr Glu Ile Asn Asn Asn Leu Asn Asn Ser Ser Gly Tyr Leu 
        275                 280                 285             


Gly Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Asn Glu Thr 
    290                 295                 300                 


Val Gly Glu Tyr Leu Trp Lys Gln Ile Ala Ala Asn Pro His Thr Ser 
305                 310                 315                 320 


Leu Lys Asn Gln Val Phe Tyr Arg Gln Asp Tyr Leu Asp Glu Phe Glu 
                325                 330                 335     


Gln Ile Trp Lys Thr Gln Ser Ala Phe Tyr Pro Glu Ile Leu Thr Asp 
            340                 345                 350         


Glu Leu Lys Lys Glu Leu Arg Asp Val Val Ile Phe Tyr Gln Arg Lys 
        355                 360                 365             


Leu Lys Ser Gln Lys Ser Leu Val Ser Phe Cys Glu Phe Glu Asn Lys 
    370                 375                 380                 


Glu Ile Glu Ile Lys Lys Glu Asp Gly Thr Ser Thr Lys Lys Val Ile 
385                 390                 395                 400 


Gly Leu Lys Val Ala Pro Lys Ser Ser Pro Leu Phe Gln Glu Phe Lys 
                405                 410                 415     


Ile Trp Gln Asn Leu Asn Asn Val Leu Ile Arg Lys Lys Gly Ser Lys 
            420                 425                 430         


Thr Lys Lys Val Ala Lys Asn Gln Gln Ala Val Leu Phe Glu Glu Glu 
        435                 440                 445             


Lys Thr Ile Ser Glu Leu Asp Leu Glu Ala Lys Gln Ala Leu Phe Asn 
    450                 455                 460                 


Glu Leu Asn Leu Lys Gly Asn Leu Lys Ala Asp Tyr Cys Leu Glu Ile 
465                 470                 475                 480 


Leu Gly Tyr Ser Pro Lys Glu Trp Glu Met Asn Tyr Ser Val Leu Glu 
                485                 490                 495     


Gly Asn Arg Thr Asn Lys Ala Leu Tyr Glu Ala Tyr Leu Lys Ile Thr 
            500                 505                 510         


Asp Leu Glu Gly Tyr Asp Ala Lys Asn His Leu Lys Val Lys Leu Asn 
        515                 520                 525             


Lys Asp Glu Val Glu Leu Asp Asp Leu Lys Val Pro Ala Ser Glu Ile 
    530                 535                 540                 


Lys Asp Met Val Gln Ala Ile Phe Lys Glu Ala Gly Ile Asn Thr Asp 
545                 550                 555                 560 


Ile Leu His Phe Asn Ala Glu Leu Asp Gly Lys Asp Phe Glu Asn Gln 
                565                 570                 575     


Ala Ser Tyr Gln Leu Trp His Leu Leu Tyr Ser Tyr Glu Gly Asp Asp 
            580                 585                 590         


Ser Lys Ser Gly Asn Glu Leu Leu Tyr Lys Leu Leu Glu Thr Lys Phe 
        595                 600                 605             


Gly Phe Lys Lys Glu Tyr Ala Gln Ile Leu Ala Asn Val Ser Leu Ser 
    610                 615                 620                 


Asp Asp Tyr Gly Ser Leu Ser Thr Lys Ala Met Arg Lys Ile His Pro 
625                 630                 635                 640 


Tyr Ile Lys Glu Asn Lys Phe Ser Thr Ala Cys Glu Leu Ala Gly Tyr 
                645                 650                 655     


Arg His Ser Lys His Ser Leu Thr Lys Glu Glu Asn Asp Asn Arg Val 
            660                 665                 670         


Leu Lys Asp Ser Leu Glu Val Leu Lys Lys Asn Ser Leu Arg Gln Pro 
        675                 680                 685             


Val Val Glu Lys Ile Leu Asn Gln Met Ile Asn Leu Val Asn Ala Leu 
    690                 695                 700                 


Leu Lys Lys Tyr Arg Thr Glu Asn Pro Asn Phe Lys Phe Asp Glu Ile 
705                 710                 715                 720 


Arg Ile Glu Leu Ala Arg Glu Leu Lys Lys Asn Ala Glu Glu Arg Ala 
                725                 730                 735     


Asn Met Thr Ala Asn Ile Asn Lys Ala Lys Thr Glu His Glu Lys Ile 
            740                 745                 750         


Ile Lys Ile Leu Lys Asn Glu Phe Gly Leu Pro Asn Pro Thr Arg Asn 
        755                 760                 765             


Asp Ile Ile Arg Tyr Arg Leu Tyr Glu Glu Leu Lys Ala Asn Gly Tyr 
    770                 775                 780                 


Lys Asp Leu Tyr Thr Asn Ile Lys Ile Pro Gln Glu Lys Leu Phe Thr 
785                 790                 795                 800 


Lys Glu Ile Asp Ile Glu His Ile Ile Pro Lys Ser Arg Val Phe Asp 
                805                 810                 815     


Asp Ser Phe Ser Asn Lys Thr Leu Ser Phe Arg Lys Thr Asn Leu Asp 
            820                 825                 830         


Lys Gly Glu Arg Thr Ala Phe Asp Tyr Met Glu Ser Lys Phe Gly Ala 
        835                 840                 845             


Asp Lys Leu Glu Glu Tyr Val Ala Arg Val Glu Asp Leu Tyr Lys Asn 
    850                 855                 860                 


Asn Ile Ile Ser Lys Ala Lys Tyr Gln Lys Leu Leu Lys Lys Glu Ser 
865                 870                 875                 880 


Glu Ile Gly Asp Gly Phe Val Glu Arg Asp Leu Arg Glu Thr Gln Tyr 
                885                 890                 895     


Ile Ala Lys Lys Ala Lys Glu Ile Leu Leu Gln Ile Thr Pro Asn Val 
            900                 905                 910         


Leu Ser Thr Ser Gly Gly Ile Thr Asp Arg Leu Arg Glu Asp Trp Asp 
        915                 920                 925             


Leu Ile Asn Val Met Lys Glu Leu Asn Leu Pro Lys Tyr Arg Ala Leu 
    930                 935                 940                 


Gly Leu Thr Gln Met Glu Asp Arg Lys Tyr Gly Gln Gln Val Glu Val 
945                 950                 955                 960 


Ile Thr Asp Trp Thr Lys Arg Asn Asp His Arg His His Ala Met Asp 
                965                 970                 975     


Ala Leu Thr Val Ala Phe Thr Lys His Asn His Ile Gln Tyr Leu Asn 
            980                 985                 990         


Tyr Leu Asn Ala Arg Lys Asn Glu  Lys His Lys Glu His  Ser Asn Ile 
        995                 1000                 1005             


Met Gly  Ile Gln Gln Leu Glu  Thr Ile Lys Val Thr  Asp Lys Asn 
    1010                 1015                 1020             


Gly Asn  Glu Lys Arg Val Phe  Lys Ala Pro Met Pro  Asn Phe Arg 
    1025                 1030                 1035             


Gln Val  Thr Lys Ala Phe Leu  Glu Asn Ile Leu Ile  Ser His Lys 
    1040                 1045                 1050             


Ala Lys  Asn Lys Val Val Thr  Lys Asn Lys Asn Lys  Val Ala Gly 
    1055                 1060                 1065             


Ser Asn  Lys Val Gln Glu Val  Leu Thr Pro Arg Gly  Gln Leu His 
    1070                 1075                 1080             


Lys Glu  Thr Val Tyr Gly Lys  Tyr Gln Tyr Tyr Val  Gln Lys Glu 
    1085                 1090                 1095             


Glu Lys  Ile Gly Ala Lys Phe  Asp Leu Glu Thr Ile  Lys Lys Val 
    1100                 1105                 1110             


Ala Asn  Pro Leu Tyr Gln Ser  Leu Leu Lys Lys Arg  Leu Glu Glu 
    1115                 1120                 1125             


Asn Gly  Gly Asp Pro Lys Lys  Ala Phe Thr Gly Lys  Asn Ser Leu 
    1130                 1135                 1140             


Ala Lys  Asn Pro Ile Tyr Leu  Asp Asp Thr Gln Thr  Glu Gln Leu 
    1145                 1150                 1155             


Pro Glu  Lys Val Lys Leu Val  Trp Leu Glu Asn Ser  Phe Ser Ile 
    1160                 1165                 1170             


Arg Lys  Asp Ile Thr Pro Glu  Asn Phe Lys Asp Glu  Lys Leu Ile 
    1175                 1180                 1185             


Asp Lys  Ile Leu Asp Glu Gly  Val Lys Arg Ile Leu  Lys Glu Arg 
    1190                 1195                 1200             


Leu Gln  Ser Phe Gly Asn Asp  Ala Lys Lys Ala Phe  Ser Asp Leu 
    1205                 1210                 1215             


Asp Lys  Asn Pro Ile Trp Leu  Asn Lys Glu Lys Gly  Ile Thr Ile 
    1220                 1225                 1230             


Lys Arg  Val Thr Ile Ser Gly  Val Ala Asn Ala Glu  Pro Leu His 
    1235                 1240                 1245             


Thr Lys  Lys Asp His Leu Gly  Lys Glu Ile Leu Asp  Lys Glu Gly 
    1250                 1255                 1260             


Lys Pro  Ile Pro Val Asp Phe  Ile Ser Thr Gly Ser  Asn His His 
    1265                 1270                 1275             


Val Ala  Val Tyr Arg Asp Glu  Lys Gly Asn Leu Gln  Glu Lys Val 
    1280                 1285                 1290             


Val Ser  Val Phe Glu Ala Val  Val Arg Ala Asn Gln  Gly Leu Pro 
    1295                 1300                 1305             


Ile Ile  Asp Lys Thr Tyr Asn  Gln His Leu Gly Trp  Glu Phe Leu 
    1310                 1315                 1320             


Phe Thr  Met Lys Gln Asn Glu  Met Phe Val Phe Pro  Asn Glu Ser 
    1325                 1330                 1335             


Thr Gly  Phe Asn Pro Asn Asp  Ile Asp Leu Leu Asp  Pro Lys Asn 
    1340                 1345                 1350             


Lys Arg  Ile Ile Ser Pro Asn  Leu Phe Arg Val Gln  Lys Phe Ser 
    1355                 1360                 1365             


Lys Leu  Gln Tyr Gly Asn Ser  Phe Val Arg Glu Phe  Val Phe Arg 
    1370                 1375                 1380             


His His  Leu Glu Thr Thr Val  Glu Asp Arg Lys Glu  Leu Gln Gly 
    1385                 1390                 1395             


Ile Thr  Tyr Lys Gln Met Lys  Asn Ser Thr Phe Phe  Asn Asp Ile 
    1400                 1405                 1410             


Ile Lys  Val Arg Ile Asn His  Leu Gly Asp Ile Val  Ser Ile Gly 
    1415                 1420                 1425             


Glu Tyr  
    1430 


<210> 94
<211> 1420
<212> PRT
<213> Bifidobacterium bifidum

<400> 94
Met Ser Arg Lys Asn Tyr Val Asp Asp Tyr Ala Ile Ser Leu Asp Ile 
1               5                   10                  15      


Gly Asn Ala Ser Val Gly Trp Ser Ala Phe Thr Pro Asn Tyr Arg Leu 
            20                  25                  30          


Val Arg Ala Lys Gly His Glu Leu Ile Gly Val Arg Leu Phe Asp Pro 
        35                  40                  45              


Ala Asp Thr Ala Glu Ser Arg Arg Met Ala Arg Thr Thr Arg Arg Arg 
    50                  55                  60                  


Tyr Ser Arg Arg Arg Trp Arg Leu Arg Leu Leu Asp Ala Leu Phe Asp 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Ile Asp Pro Ser Phe Leu Ala Arg Arg Lys Tyr 
                85                  90                  95      


Ser Trp Val His Pro Asp Asp Glu Asn Asn Ala Asp Cys Trp Tyr Gly 
            100                 105                 110         


Ser Val Leu Phe Asp Ser Asn Glu Gln Asp Lys Arg Phe Tyr Glu Lys 
        115                 120                 125             


Tyr Pro Thr Ile Tyr His Leu Arg Lys Ala Leu Met Glu Asp Asp Ser 
    130                 135                 140                 


Gln His Asp Ile Arg Glu Ile Tyr Leu Ala Ile His His Met Val Lys 
145                 150                 155                 160 


Tyr Arg Gly Asn Phe Leu Val Glu Gly Thr Leu Glu Ser Ser Asn Ala 
                165                 170                 175     


Phe Lys Glu Asp Glu Leu Leu Lys Leu Leu Gly Arg Ile Thr Arg Tyr 
            180                 185                 190         


Glu Met Ser Glu Gly Glu Gln Asn Ser Asp Ile Glu Gln Asp Asp Glu 
        195                 200                 205             


Asn Lys Leu Val Ala Pro Ala Asn Gly Gln Leu Ala Asp Ala Leu Cys 
    210                 215                 220                 


Ala Thr Arg Gly Ser Arg Ser Met Arg Val Asp Asn Ala Leu Glu Ala 
225                 230                 235                 240 


Leu Ser Ala Val Asn Asp Leu Ser Arg Glu Gln Arg Ala Ile Val Lys 
                245                 250                 255     


Ala Ile Phe Ala Gly Leu Glu Gly Asn Lys Leu Asp Leu Ala Lys Ile 
            260                 265                 270         


Phe Val Ser Lys Glu Phe Ser Ser Glu Asn Lys Lys Ile Leu Gly Ile 
        275                 280                 285             


Tyr Phe Asn Lys Ser Asp Tyr Glu Glu Lys Cys Val Gln Ile Val Asp 
    290                 295                 300                 


Ser Gly Leu Leu Asp Asp Glu Glu Arg Glu Phe Leu Asp Arg Met Gln 
305                 310                 315                 320 


Gly Gln Tyr Asn Ala Ile Ala Leu Lys Gln Leu Leu Gly Arg Ser Thr 
                325                 330                 335     


Ser Val Ser Asp Ser Lys Cys Ala Ser Tyr Asp Ala His Arg Ala Asn 
            340                 345                 350         


Trp Asn Leu Ile Lys Leu Gln Leu Arg Thr Lys Glu Asn Glu Lys Asp 
        355                 360                 365             


Ile Asn Glu Asn Tyr Gly Ile Leu Val Gly Trp Lys Ile Asp Ser Gly 
    370                 375                 380                 


Gln Arg Lys Ser Val Arg Gly Glu Ser Ala Tyr Glu Asn Met Arg Lys 
385                 390                 395                 400 


Lys Ala Asn Val Phe Phe Lys Lys Met Ile Glu Thr Ser Asp Leu Ser 
                405                 410                 415     


Glu Thr Asp Lys Asn Arg Leu Ile His Asp Ile Glu Glu Asp Lys Leu 
            420                 425                 430         


Phe Pro Ile Gln Arg Asp Ser Asp Asn Gly Val Ile Pro His Gln Leu 
        435                 440                 445             


His Gln Asn Glu Leu Lys Gln Ile Ile Lys Lys Gln Gly Lys Tyr Tyr 
    450                 455                 460                 


Pro Phe Leu Leu Asp Ala Phe Glu Lys Asp Gly Lys Gln Ile Asn Lys 
465                 470                 475                 480 


Ile Glu Gly Leu Leu Thr Phe Arg Val Pro Tyr Phe Val Gly Pro Leu 
                485                 490                 495     


Val Val Pro Glu Asp Leu Gln Lys Ser Asp Asn Ser Glu Asn His Trp 
            500                 505                 510         


Met Val Arg Lys Lys Lys Gly Glu Ile Thr Pro Trp Asn Phe Asp Glu 
        515                 520                 525             


Met Val Asp Lys Asp Ala Ser Gly Arg Lys Phe Ile Glu Arg Leu Val 
    530                 535                 540                 


Gly Thr Asp Ser Tyr Leu Leu Gly Glu Pro Thr Leu Pro Lys Asn Ser 
545                 550                 555                 560 


Leu Leu Tyr Gln Glu Tyr Glu Val Leu Asn Glu Leu Asn Asn Val Arg 
                565                 570                 575     


Leu Ser Val Arg Thr Gly Asn His Trp Asn Asp Lys Arg Arg Met Arg 
            580                 585                 590         


Leu Gly Arg Glu Glu Lys Thr Leu Leu Cys Gln Arg Leu Phe Met Lys 
        595                 600                 605             


Gly Gln Thr Val Thr Lys Arg Thr Ala Glu Asn Leu Leu Arg Lys Glu 
    610                 615                 620                 


Tyr Gly Arg Thr Tyr Glu Leu Ser Gly Leu Ser Asp Glu Ser Lys Phe 
625                 630                 635                 640 


Thr Ser Ser Leu Ser Thr Tyr Gly Lys Met Cys Arg Ile Phe Gly Glu 
                645                 650                 655     


Lys Tyr Val Asn Glu His Arg Asp Leu Met Glu Lys Ile Val Glu Leu 
            660                 665                 670         


Gln Thr Val Phe Glu Asp Lys Glu Thr Leu Leu His Gln Leu Arg Gln 
        675                 680                 685             


Leu Glu Gly Ile Ser Glu Ala Asp Cys Ala Leu Leu Val Asn Thr His 
    690                 695                 700                 


Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Leu Thr Thr Lys Ala 
705                 710                 715                 720 


Gly Glu Cys Lys Ile Ser Asp Asp Phe Ala Pro Arg Lys His Ser Ile 
                725                 730                 735     


Ile Glu Ile Met Arg Ala Glu Asp Arg Asn Leu Met Glu Ile Ile Thr 
            740                 745                 750         


Asp Lys Gln Leu Gly Phe Ser Asp Trp Ile Glu Gln Glu Asn Leu Gly 
        755                 760                 765             


Ala Glu Asn Gly Ser Ser Leu Met Glu Val Val Asp Asp Leu Arg Val 
    770                 775                 780                 


Ser Pro Lys Val Lys Arg Gly Ile Ile Gln Ser Ile Arg Leu Ile Asp 
785                 790                 795                 800 


Asp Ile Ser Lys Ala Val Gly Lys Arg Pro Ser Arg Ile Phe Leu Glu 
                805                 810                 815     


Leu Ala Asp Asp Ile Gln Pro Ser Gly Arg Thr Ile Ser Arg Lys Ser 
            820                 825                 830         


Arg Leu Gln Asp Leu Tyr Arg Asn Ala Asn Leu Gly Lys Glu Phe Lys 
        835                 840                 845             


Gly Ile Ala Asp Glu Leu Asn Ala Cys Ser Asp Lys Asp Leu Gln Asp 
    850                 855                 860                 


Asp Arg Leu Phe Leu Tyr Tyr Thr Gln Leu Gly Lys Asp Met Tyr Thr 
865                 870                 875                 880 


Gly Glu Glu Leu Asp Leu Asp Arg Leu Ser Ser Ala Tyr Asp Ile Asp 
                885                 890                 895     


His Ile Ile Pro Gln Ala Val Thr Gln Asn Asp Ser Ile Asp Asn Arg 
            900                 905                 910         


Val Leu Val Ala Arg Ala Glu Asn Ala Arg Lys Thr Asp Ser Phe Thr 
        915                 920                 925             


Tyr Met Pro Gln Ile Ala Asp Arg Met Arg Asn Phe Trp Gln Ile Leu 
    930                 935                 940                 


Leu Asp Asn Gly Leu Ile Ser Arg Val Lys Phe Glu Arg Leu Thr Arg 
945                 950                 955                 960 


Gln Asn Glu Phe Ser Glu Arg Glu Lys Glu Arg Phe Val Gln Arg Ser 
                965                 970                 975     


Leu Val Glu Thr Arg Gln Ile Met Lys Asn Val Ala Thr Leu Met Arg 
            980                 985                 990         


Gln Arg Tyr Gly Asn Ser Ala Ala  Val Ile Gly Leu Asn  Ala Glu Leu 
        995                 1000                 1005             


Thr Lys  Glu Met His Arg Tyr  Leu Gly Phe Ser His  Lys Asn Arg 
    1010                 1015                 1020             


Asp Ile  Asn Asp Tyr His His  Ala Gln Asp Ala Leu  Cys Val Gly 
    1025                 1030                 1035             


Ile Ala  Gly Gln Phe Ala Ala  Asn Arg Gly Phe Phe  Ala Asp Gly 
    1040                 1045                 1050             


Glu Val  Ser Asp Gly Ala Gln  Asn Ser Tyr Asn Gln  Tyr Leu Arg 
    1055                 1060                 1065             


Asp Tyr  Leu Arg Gly Tyr Arg  Glu Lys Leu Ser Ala  Glu Asp Arg 
    1070                 1075                 1080             


Lys Gln  Gly Arg Ala Phe Gly  Phe Ile Val Gly Ser  Met Arg Ser 
    1085                 1090                 1095             


Gln Asp  Glu Gln Lys Arg Val  Asn Pro Arg Thr Gly  Glu Val Val 
    1100                 1105                 1110             


Trp Ser  Glu Glu Asp Lys Asp  Tyr Leu Arg Lys Val  Met Asn Tyr 
    1115                 1120                 1125             


Arg Lys  Met Leu Val Thr Gln  Lys Val Gly Asp Asp  Phe Gly Ala 
    1130                 1135                 1140             


Leu Tyr  Asp Glu Thr Arg Tyr  Ala Ala Thr Asp Pro  Lys Gly Ile 
    1145                 1150                 1155             


Lys Gly  Ile Pro Phe Asp Gly  Ala Lys Gln Asp Thr  Ser Leu Tyr 
    1160                 1165                 1170             


Gly Gly  Phe Ser Ser Ala Lys  Pro Ala Tyr Ala Val  Leu Ile Glu 
    1175                 1180                 1185             


Ser Lys  Gly Lys Thr Arg Leu  Val Asn Val Thr Met  Gln Glu Tyr 
    1190                 1195                 1200             


Ser Leu  Leu Gly Asp Arg Pro  Ser Asp Asp Glu Leu  Arg Lys Val 
    1205                 1210                 1215             


Leu Ala  Lys Lys Lys Ser Glu  Tyr Ala Lys Ala Asn  Ile Leu Leu 
    1220                 1225                 1230             


Arg His  Val Pro Lys Met Gln  Leu Ile Arg Tyr Gly  Gly Gly Leu 
    1235                 1240                 1245             


Met Val  Ile Lys Ser Ala Gly  Glu Leu Asn Asn Ala  Gln Gln Leu 
    1250                 1255                 1260             


Trp Leu  Pro Tyr Glu Glu Tyr  Cys Tyr Phe Asp Asp  Leu Ser Gln 
    1265                 1270                 1275             


Gly Lys  Gly Ser Leu Glu Lys  Asp Asp Leu Lys Lys  Leu Leu Asp 
    1280                 1285                 1290             


Ser Ile  Leu Gly Ser Val Gln  Cys Leu Tyr Pro Trp  His Arg Phe 
    1295                 1300                 1305             


Thr Glu  Glu Glu Leu Ala Asp  Leu His Val Ala Phe  Asp Lys Leu 
    1310                 1315                 1320             


Pro Glu  Asp Glu Lys Lys Asn  Val Ile Thr Gly Ile  Val Ser Ala 
    1325                 1330                 1335             


Leu His  Ala Asp Ala Lys Thr  Ala Asn Leu Ser Ile  Val Gly Met 
    1340                 1345                 1350             


Thr Gly  Ser Trp Arg Arg Met  Asn Asn Lys Ser Gly  Tyr Thr Phe 
    1355                 1360                 1365             


Ser Asp  Glu Asp Glu Phe Ile  Phe Gln Ser Pro Ser  Gly Leu Phe 
    1370                 1375                 1380             


Glu Lys  Arg Val Thr Val Gly  Glu Leu Lys Arg Lys  Ala Lys Lys 
    1385                 1390                 1395             


Glu Val  Asn Ser Lys Tyr Arg  Thr Asn Glu Lys Arg  Leu Pro Thr 
    1400                 1405                 1410             


Leu Ser  Gly Ala Ser Gln Pro  
    1415                 1420 


<210> 95
<211> 1138
<212> PRT
<213> Bifidobacterium dentium

<400> 95
Met Leu Cys Arg Cys His Arg Arg Tyr Arg Ile Gly Ile Asp Val Gly 
1               5                   10                  15      


Leu Met Ser Val Gly Leu Ala Ala Ile Glu Val Asp Glu Thr Gly Phe 
            20                  25                  30          


Pro Ile Arg Ile Leu Asn Ile Gln Ser Val Ile His Asp Gly Gly Ile 
        35                  40                  45              


Asp Pro Gln Leu Gly Lys Lys Lys Ser Ile Ser Arg Lys Ala Ile Ser 
    50                  55                  60                  


Gly Val Ala Arg Arg Thr Arg Arg Met Arg Arg Arg Lys Val Val Arg 
65                  70                  75                  80  


Leu Arg Gln Leu Asp Ala Thr Leu Glu Ser Leu Gly Phe Pro Ile Val 
                85                  90                  95      


Glu Pro Asp Ser Leu Asp Thr Trp Glu Ile Trp Leu Thr Arg Ala Lys 
            100                 105                 110         


Leu Ala Ser Ser Tyr Ile Gln Asp Asp Glu Thr Arg Lys Glu Asp Val 
        115                 120                 125             


Ser Ile Ala Leu Arg His Ile Ala Arg His Arg Gly Trp Arg Asn Pro 
    130                 135                 140                 


Tyr Ser Asn Val Glu Ser Leu Phe Val Asp Val Ala Pro Ser Glu Gln 
145                 150                 155                 160 


Tyr Glu Glu Leu Arg Arg Lys Ala Glu Glu Lys Leu Gly Thr Ser Leu 
                165                 170                 175     


Ser Gly Asn Pro Thr Ser Ala Glu Ile Val Glu Cys Ile Leu Lys Arg 
            180                 185                 190         


Gln Val Gly Glu Val Gln Leu Arg Thr Arg Ser Arg Lys Gly Val Asn 
        195                 200                 205             


Gly Asn Ala Val Glu Lys Glu Gly Leu Leu Pro Thr Lys Leu Met Gln 
    210                 215                 220                 


Ser Asp Asn Ala Ala Glu Ile Arg Arg Ile Phe Lys Val Gln Arg Ile 
225                 230                 235                 240 


Asp Asp Glu Thr Gly Arg Lys Leu Leu Arg Ala Val Phe Lys Ala Cys 
                245                 250                 255     


Ser Pro Lys Gly Ser Val Glu Arg Arg Val Gly Arg Asp Ala Leu Ala 
            260                 265                 270         


Pro Gly Leu Pro Arg Ala Leu Lys Ala Ser Leu Ala Phe Gln Glu Tyr 
        275                 280                 285             


Arg Ile Ala Asn Val Leu Thr Asn Leu Val Ile Ser Glu Asp Gly Thr 
    290                 295                 300                 


Lys Arg Lys Leu Thr Ile Ala Glu Lys Gln Arg Val Phe Gly Phe Leu 
305                 310                 315                 320 


Ser Ser Asn Glu Thr Asp Asp Ile Thr Trp Ile Asp Val Ala Glu Lys 
                325                 330                 335     


Leu Gly Leu Glu Arg Arg Gln Ile Gln Gly Val Gly Cys Leu Thr Ala 
            340                 345                 350         


Asp Gly Glu Glu Arg Ile Ser Ser Thr Pro Pro Arg Asn Ile Thr Ala 
        355                 360                 365             


Leu His Ile His Ser Ala Lys Pro Val Ile Arg Glu Lys Leu Val Ala 
    370                 375                 380                 


Trp Trp Lys Ala Ala Ser Pro Thr Val Arg Glu Thr Met Val Glu Leu 
385                 390                 395                 400 


Leu Ser Asn Thr Val Asp Ile Asp Arg Val Arg Glu Asp Met Asp Tyr 
                405                 410                 415     


Ser Ser Ala Val Ala Phe Ile Asp Ser Leu Gly Asp Glu Glu Leu Thr 
            420                 425                 430         


Ala Leu Asp Ser Val Asp Leu Leu Ser Gly Arg Ala Ala Tyr Ser Arg 
        435                 440                 445             


Gln Thr Leu Lys Gln Leu Thr Glu Arg Met Leu Asn Thr Asp Asp Asp 
    450                 455                 460                 


Leu His Glu Ala Arg Lys Ala Val Phe Gly Val Asp Asp Asn Trp Lys 
465                 470                 475                 480 


Pro Pro Val Asp Ala Ile Ser Thr Ser Val Gly Asn Pro Ala Val Asp 
                485                 490                 495     


Arg Val Leu Lys Ile Val Asn Arg Tyr Leu Leu Ala Cys Gln Lys Arg 
            500                 505                 510         


Trp Arg Asn Pro Gln Ser Val Gln Ile Glu His Val Arg Glu Ser Phe 
        515                 520                 525             


Ser Ser Val Ala Lys Ala Lys Glu Thr Glu Arg Val Gln Gly Glu Arg 
    530                 535                 540                 


Ala Arg Tyr Arg Asn Asp Leu Arg Arg Glu Leu Cys Glu Gln Glu Gly 
545                 550                 555                 560 


Leu Asn Lys Ile Arg Glu Ser Asp Ile Arg Arg Trp Glu Ser Val Gln 
                565                 570                 575     


Arg Gln Asn Gly Thr Cys Leu Tyr Cys Gly Ser Pro Ile Thr Phe Arg 
            580                 585                 590         


Thr Cys Glu Met Asp His Ile Val Pro Arg Lys Gly Val Gly Ser Thr 
        595                 600                 605             


Asn Thr Arg Val Asn Leu Ala Ala Ala Cys Ala Ala Cys Asn Lys Leu 
    610                 615                 620                 


Lys Ser Asn Thr Ala Phe Ser Val Trp Ala Arg Thr Glu Gly Ala Ala 
625                 630                 635                 640 


Asn Arg Lys Val Ser Gln Arg Asp Ala Ile Glu Arg Val Lys Thr Phe 
                645                 650                 655     


Ile Phe Asn Lys Ser Val Pro Pro Arg Glu Gln Arg Ala Phe Lys Gln 
            660                 665                 670         


Ala Val Ile Ser Arg Leu Arg Gln Ala Glu Ser Asp Pro Ala Ile Asp 
        675                 680                 685             


Asn Arg Ser Ile Glu Ser Val Ala Trp Met Ala Asp Glu Leu His Arg 
    690                 695                 700                 


Arg Ile Glu Ala Tyr Phe Asn Gln Asp Ala Asp Val Ser Gly Asn Thr 
705                 710                 715                 720 


Pro Ala Thr Gln Val Trp Val Phe Gln Gly Arg Val Thr Ala Leu Ala 
                725                 730                 735     


Arg Lys Ala Ser Gly Ile Glu Gly Arg Ile His Phe Ala Gly Glu Trp 
            740                 745                 750         


Lys Lys Thr Arg Leu Asp Arg Arg His His Ala Val Asp Ala Ala Val 
        755                 760                 765             


Ile Ala Met Met Asn His Ser Ala Ala Gln Thr Leu Val Glu Arg Asp 
    770                 775                 780                 


Ser Leu Arg Leu Ser Gln Trp Ile Thr Arg Lys Pro Glu Thr Trp Lys 
785                 790                 795                 800 


Asn Tyr Pro Phe Ser Glu Gly Gln Lys Lys Thr Arg Phe Lys Glu Trp 
                805                 810                 815     


Leu Asp Cys Met Asn Ala Leu Leu Asp Leu Leu Asn Asp Ala Leu Asp 
            820                 825                 830         


Ser Asp Arg Val Pro Val Thr Arg Cys Gln Arg Met Ser Leu Gly Asn 
        835                 840                 845             


Ser Gln Ala His Ala Ala Thr Ile Arg Lys Met Lys Arg Val Glu Leu 
    850                 855                 860                 


Phe Ser Pro Met Asp Ala Asp Leu Ile Arg Arg Ala Ser Thr Pro Ala 
865                 870                 875                 880 


Leu Tyr Cys Ala Leu Thr Arg Leu Pro Glu Tyr Ser Pro Glu Lys Gly 
                885                 890                 895     


Leu Pro Glu Asn Arg Gly Arg Glu Ile Val Leu Asn Gly Arg His Ile 
            900                 905                 910         


Arg Ser Thr Glu Thr Val Asp Phe Phe Ala Ser Gly Ala Ala Gln Leu 
        915                 920                 925             


Met Val Arg Asn Gly Ser Ala Glu Ile Gly Asp Ser Ile His His Met 
    930                 935                 940                 


Arg Ile Tyr Arg Tyr Arg Lys Thr Gly Ala Lys Ser Gln Glu Tyr Val 
945                 950                 955                 960 


Tyr Gly Met Ile Arg Val Phe Gln Ile Asp Leu Leu His Ala Ser Ser 
                965                 970                 975     


Glu Asn Leu Phe Ala Val Gln Leu Pro Ser Gln Ser Val Ser Val Arg 
            980                 985                 990         


Tyr Gly Asp Lys Asn Val Val Gln  Ala Ile Gln Glu Gly  Arg Ala Glu 
        995                 1000                 1005             


Tyr Leu  Gly His Ile Val Pro  Asn Asp Glu Ile Leu  Ile Ser Tyr 
    1010                 1015                 1020             


Glu Gly  Val Arg Met Lys Asp  Ser Glu Lys Ile Gly  Ala Tyr Ala 
    1025                 1030                 1035             


Asn Asp  Phe Ser Gly Thr Ala  Ser Glu Leu Ala Gln  Arg Arg His 
    1040                 1045                 1050             


Trp Val  Val Val Gly Ser Asp  Val Ser Lys Leu Ala  Leu Arg Pro 
    1055                 1060                 1065             


Ser Tyr  Leu Ser Glu Glu Gly  Leu Glu Asn Ser Gly  Ser Glu Ser 
    1070                 1075                 1080             


Glu Arg  Leu Ser Lys Gln Thr  Arg Lys Val Ile Glu  Gly Lys Gly 
    1085                 1090                 1095             


Trp Val  Val Ala Val Asn Ile  Leu Ala Lys Tyr His  Pro Val Val 
    1100                 1105                 1110             


Ile Arg  Arg Asn Ala Leu Gly  Glu Pro Arg Phe Arg  Thr Asn Ser 
    1115                 1120                 1125             


Gly Met  Pro Val Ser Trp Arg  Trp Asp Arg 
    1130                 1135             


<210> 96
<211> 1187
<212> PRT
<213> Bifidobacterium longum

<400> 96
Met Leu Ser Arg Gln Leu Leu Gly Ala Ser His Leu Ala Arg Pro Val 
1               5                   10                  15      


Ser Tyr Ser Tyr Asn Val Gln Asp Asn Asp Val His Cys Ser Tyr Gly 
            20                  25                  30          


Glu Arg Cys Phe Met Arg Gly Lys Arg Tyr Arg Ile Gly Ile Asp Val 
        35                  40                  45              


Gly Leu Asn Ser Val Gly Leu Ala Ala Val Glu Val Ser Asp Glu Asn 
    50                  55                  60                  


Ser Pro Val Arg Leu Leu Asn Ala Gln Ser Val Ile His Asp Gly Gly 
65                  70                  75                  80  


Val Asp Pro Gln Lys Asn Lys Glu Ala Ile Thr Arg Lys Asn Met Ser 
                85                  90                  95      


Gly Val Ala Arg Arg Thr Arg Arg Met Arg Arg Arg Lys Arg Glu Arg 
            100                 105                 110         


Leu His Lys Leu Asp Met Leu Leu Gly Lys Phe Gly Tyr Pro Val Ile 
        115                 120                 125             


Glu Pro Glu Ser Leu Asp Lys Pro Phe Glu Glu Trp His Val Arg Ala 
    130                 135                 140                 


Glu Leu Ala Thr Arg Tyr Ile Glu Asp Asp Glu Leu Arg Arg Glu Ser 
145                 150                 155                 160 


Ile Ser Ile Ala Leu Arg His Met Ala Arg His Arg Gly Trp Arg Asn 
                165                 170                 175     


Pro Tyr Arg Gln Val Asp Ser Leu Ile Ser Asp Asn Pro Tyr Ser Lys 
            180                 185                 190         


Gln Tyr Gly Glu Leu Lys Glu Lys Ala Lys Ala Tyr Asn Asp Asp Ala 
        195                 200                 205             


Thr Ala Ala Glu Glu Glu Ser Thr Pro Ala Gln Leu Val Val Ala Met 
    210                 215                 220                 


Leu Asp Ala Gly Tyr Ala Glu Ala Pro Arg Leu Arg Trp Arg Thr Gly 
225                 230                 235                 240 


Ser Lys Lys Pro Asp Ala Glu Gly Tyr Leu Pro Val Arg Leu Met Gln 
                245                 250                 255     


Glu Asp Asn Ala Asn Glu Leu Lys Gln Ile Phe Arg Val Gln Arg Val 
            260                 265                 270         


Pro Ala Asp Glu Trp Lys Pro Leu Phe Arg Ser Val Phe Tyr Ala Val 
        275                 280                 285             


Ser Pro Lys Gly Ser Ala Glu Gln Arg Val Gly Gln Asp Pro Leu Ala 
    290                 295                 300                 


Pro Glu Gln Ala Arg Ala Leu Lys Ala Ser Leu Ala Phe Gln Glu Tyr 
305                 310                 315                 320 


Arg Ile Ala Asn Val Ile Thr Asn Leu Arg Ile Lys Asp Ala Ser Ala 
                325                 330                 335     


Glu Leu Arg Lys Leu Thr Val Asp Glu Lys Gln Ser Ile Tyr Asp Gln 
            340                 345                 350         


Leu Val Ser Pro Ser Ser Glu Asp Ile Thr Trp Ser Asp Leu Cys Asp 
        355                 360                 365             


Phe Leu Gly Phe Lys Arg Ser Gln Leu Lys Gly Val Gly Ser Leu Thr 
    370                 375                 380                 


Glu Asp Gly Glu Glu Arg Ile Ser Ser Arg Pro Pro Arg Leu Thr Ser 
385                 390                 395                 400 


Val Gln Arg Ile Tyr Glu Ser Asp Asn Lys Ile Arg Lys Pro Leu Val 
                405                 410                 415     


Ala Trp Trp Lys Ser Ala Ser Asp Asn Glu His Glu Ala Met Ile Arg 
            420                 425                 430         


Leu Leu Ser Asn Thr Val Asp Ile Asp Lys Val Arg Glu Asp Val Ala 
        435                 440                 445             


Tyr Ala Ser Ala Ile Glu Phe Ile Asp Gly Leu Asp Asp Asp Ala Leu 
    450                 455                 460                 


Thr Lys Leu Asp Ser Val Asp Leu Pro Ser Gly Arg Ala Ala Tyr Ser 
465                 470                 475                 480 


Val Glu Thr Leu Gln Lys Leu Thr Arg Gln Met Leu Thr Thr Asp Asp 
                485                 490                 495     


Asp Leu His Glu Ala Arg Lys Thr Leu Phe Asn Val Thr Asp Ser Trp 
            500                 505                 510         


Arg Pro Pro Ala Asp Pro Ile Gly Glu Pro Leu Gly Asn Pro Ser Val 
        515                 520                 525             


Asp Arg Val Leu Lys Asn Val Asn Arg Tyr Leu Met Asn Cys Gln Gln 
    530                 535                 540                 


Arg Trp Gly Asn Pro Val Ser Val Asn Ile Glu His Val Arg Ser Ser 
545                 550                 555                 560 


Phe Ser Ser Val Ala Phe Ala Arg Lys Asp Lys Arg Glu Tyr Glu Lys 
                565                 570                 575     


Asn Asn Glu Lys Arg Ser Ile Phe Arg Ser Ser Leu Ser Glu Gln Leu 
            580                 585                 590         


Arg Ala Asp Glu Gln Met Glu Lys Val Arg Glu Ser Asp Leu Arg Arg 
        595                 600                 605             


Leu Glu Ala Ile Gln Arg Gln Asn Gly Gln Cys Leu Tyr Cys Gly Arg 
    610                 615                 620                 


Thr Ile Thr Phe Arg Thr Cys Glu Met Asp His Ile Val Pro Arg Lys 
625                 630                 635                 640 


Gly Val Gly Ser Thr Asn Thr Arg Thr Asn Phe Ala Ala Val Cys Ala 
                645                 650                 655     


Glu Cys Asn Arg Met Lys Ser Asn Thr Pro Phe Ala Ile Trp Ala Arg 
            660                 665                 670         


Ser Glu Asp Ala Gln Thr Arg Gly Val Ser Leu Ala Glu Ala Lys Lys 
        675                 680                 685             


Arg Val Thr Met Phe Thr Phe Asn Pro Lys Ser Tyr Ala Pro Arg Glu 
    690                 695                 700                 


Val Lys Ala Phe Lys Gln Ala Val Ile Ala Arg Leu Gln Gln Thr Glu 
705                 710                 715                 720 


Asp Asp Ala Ala Ile Asp Asn Arg Ser Ile Glu Ser Val Ala Trp Met 
                725                 730                 735     


Ala Asp Glu Leu His Arg Arg Ile Asp Trp Tyr Phe Asn Ala Lys Gln 
            740                 745                 750         


Tyr Val Asn Ser Ala Ser Ile Asp Asp Ala Glu Ala Glu Thr Met Lys 
        755                 760                 765             


Thr Thr Val Ser Val Phe Gln Gly Arg Val Thr Ala Ser Ala Arg Arg 
    770                 775                 780                 


Ala Ala Gly Ile Glu Gly Lys Ile His Phe Ile Gly Gln Gln Ser Lys 
785                 790                 795                 800 


Thr Arg Leu Asp Arg Arg His His Ala Val Asp Ala Ser Val Ile Ala 
                805                 810                 815     


Met Met Asn Thr Ala Ala Ala Gln Thr Leu Met Glu Arg Glu Ser Leu 
            820                 825                 830         


Arg Glu Ser Gln Arg Leu Ile Gly Leu Met Pro Gly Glu Arg Ser Trp 
        835                 840                 845             


Lys Glu Tyr Pro Tyr Glu Gly Thr Ser Arg Tyr Glu Ser Phe His Leu 
    850                 855                 860                 


Trp Leu Asp Asn Met Asp Val Leu Leu Glu Leu Leu Asn Asp Ala Leu 
865                 870                 875                 880 


Asp Asn Asp Arg Ile Ala Val Met Gln Ser Gln Arg Tyr Val Leu Gly 
                885                 890                 895     


Asn Ser Ile Ala His Asp Ala Thr Ile His Pro Leu Glu Lys Val Pro 
            900                 905                 910         


Leu Gly Ser Ala Met Ser Ala Asp Leu Ile Arg Arg Ala Ser Thr Pro 
        915                 920                 925             


Ala Leu Trp Cys Ala Leu Thr Arg Leu Pro Asp Tyr Asp Glu Lys Glu 
    930                 935                 940                 


Gly Leu Pro Glu Asp Ser His Arg Glu Ile Arg Val His Asp Thr Arg 
945                 950                 955                 960 


Tyr Ser Ala Asp Asp Glu Met Gly Phe Phe Ala Ser Gln Ala Ala Gln 
                965                 970                 975     


Ile Ala Val Gln Glu Gly Ser Ala Asp Ile Gly Ser Ala Ile His His 
            980                 985                 990         


Ala Arg Val Tyr Arg Cys Trp Lys  Thr Asn Ala Lys Gly  Val Arg Lys 
        995                 1000                 1005             


Tyr Phe  Tyr Gly Met Ile Arg  Val Phe Gln Thr Asp  Leu Leu Arg 
    1010                 1015                 1020             


Ala Cys  His Asp Asp Leu Phe  Thr Val Pro Leu Pro  Pro Gln Ser 
    1025                 1030                 1035             


Ile Ser  Met Arg Tyr Gly Glu  Pro Arg Val Val Gln  Ala Leu Gln 
    1040                 1045                 1050             


Ser Gly  Asn Ala Gln Tyr Leu  Gly Ser Leu Val Val  Gly Asp Glu 
    1055                 1060                 1065             


Ile Glu  Met Asp Phe Ser Ser  Leu Asp Val Asp Gly  Gln Ile Gly 
    1070                 1075                 1080             


Glu Tyr  Leu Gln Phe Phe Ser  Gln Phe Ser Gly Gly  Asn Leu Ala 
    1085                 1090                 1095             


Trp Lys  His Trp Val Val Asp  Gly Phe Phe Asn Gln  Thr Gln Leu 
    1100                 1105                 1110             


Arg Ile  Arg Pro Arg Tyr Leu  Ala Ala Glu Gly Leu  Ala Lys Ala 
    1115                 1120                 1125             


Phe Ser  Asp Asp Val Val Pro  Asp Gly Val Gln Lys  Ile Val Thr 
    1130                 1135                 1140             


Lys Gln  Gly Trp Leu Pro Pro  Val Asn Thr Ala Ser  Lys Thr Ala 
    1145                 1150                 1155             


Val Arg  Ile Val Arg Arg Asn  Ala Phe Gly Glu Pro  Arg Leu Ser 
    1160                 1165                 1170             


Ser Ala  His His Met Pro Cys  Ser Trp Gln Trp Arg  His Glu 
    1175                 1180                 1185         


<210> 97
<211> 1124
<212> PRT
<213> Bifidobacterium longum


<220>
<223> Bifidobacterium longum subsp. longum 2-2B

<400> 97
Leu Thr Gly His Ser Gly His Thr Phe Trp Pro Thr Ser Ser Ser Pro 
1               5                   10                  15      


Pro Ile Gln Leu Glu Gln Glu Lys Arg Pro Leu Pro Gln Arg Asn Thr 
            20                  25                  30          


Ser Gln Asn Gly His Thr Phe Trp Pro Ile Thr Arg Glu Arg Cys Phe 
        35                  40                  45              


Met Arg Gly Lys Arg Tyr Arg Ile Gly Ile Asp Val Gly Leu Asn Ser 
    50                  55                  60                  


Val Gly Leu Ala Ala Val Glu Val Ser Asp Glu Asn Ser Pro Val Arg 
65                  70                  75                  80  


Leu Leu Asn Ala Gln Ser Val Ile His Asp Gly Gly Val Asp Pro Gln 
                85                  90                  95      


Lys Asn Lys Glu Ala Ile Thr Arg Lys Asn Met Ser Gly Val Ala Arg 
            100                 105                 110         


Arg Thr Arg Arg Met Arg Arg Arg Lys Arg Glu Arg Leu His Lys Leu 
        115                 120                 125             


Asp Met Leu Leu Gly Lys Phe Gly Tyr Pro Val Ile Glu Pro Glu Ser 
    130                 135                 140                 


Leu Asp Lys Pro Phe Glu Glu Trp His Val Arg Ala Glu Leu Ala Thr 
145                 150                 155                 160 


Arg Tyr Ile Glu Asp Asp Glu Leu Arg Arg Glu Ser Ile Ser Ile Ala 
                165                 170                 175     


Leu Arg His Met Ala Arg His Arg Gly Trp Arg Asn Pro Tyr Arg Gln 
            180                 185                 190         


Val Asp Ser Leu Ile Ser Asp Asn Pro Tyr Ser Lys Gln Tyr Gly Glu 
        195                 200                 205             


Leu Lys Glu Lys Ala Lys Ala Tyr Asn Asp Asp Ala Thr Ala Ala Glu 
    210                 215                 220                 


Glu Glu Ser Thr Pro Ala Gln Leu Val Val Ala Met Leu Asp Ala Gly 
225                 230                 235                 240 


Tyr Ala Glu Ala Pro Arg Leu Arg Trp Arg Thr Gly Ser Lys Lys Pro 
                245                 250                 255     


Asp Ala Glu Gly Tyr Leu Pro Val Arg Leu Met Gln Glu Asp Asn Ala 
            260                 265                 270         


Asn Glu Leu Lys Gln Ile Phe Arg Val Gln Arg Val Pro Ala Asp Glu 
        275                 280                 285             


Trp Lys Pro Leu Phe Arg Ser Val Phe Tyr Ala Val Ser Pro Lys Gly 
    290                 295                 300                 


Ser Ala Glu Gln Arg Val Gly Gln Asp Pro Leu Ala Pro Glu Gln Ala 
305                 310                 315                 320 


Arg Ala Leu Lys Ala Ser Leu Ala Phe Gln Glu Tyr Arg Ile Ala Asn 
                325                 330                 335     


Val Ile Thr Asn Leu Arg Ile Lys Asp Ala Ser Ala Glu Leu Arg Lys 
            340                 345                 350         


Leu Thr Val Asp Glu Lys Gln Ser Ile Tyr Asp Gln Leu Val Ser Pro 
        355                 360                 365             


Ser Ser Glu Asp Ile Thr Trp Ser Asp Leu Cys Asp Phe Leu Gly Phe 
    370                 375                 380                 


Lys Arg Ser Gln Leu Lys Gly Val Gly Ser Leu Thr Glu Asp Gly Glu 
385                 390                 395                 400 


Glu Arg Ile Ser Ser Arg Pro Pro Arg Leu Thr Ser Val Gln Arg Ile 
                405                 410                 415     


Tyr Glu Ser Asp Asn Lys Ile Arg Lys Pro Leu Val Ala Trp Trp Lys 
            420                 425                 430         


Ser Ala Ser Asp Asn Glu His Glu Ala Met Ile Arg Leu Leu Ser Asn 
        435                 440                 445             


Thr Val Asp Ile Asp Lys Val Arg Glu Asp Val Ala Tyr Ala Ser Ala 
    450                 455                 460                 


Ile Glu Phe Ile Asp Gly Leu Asp Asp Asp Ala Leu Thr Lys Leu Asp 
465                 470                 475                 480 


Ser Val Asp Leu Pro Ser Gly Arg Ala Ala Tyr Ser Val Glu Thr Leu 
                485                 490                 495     


Gln Lys Leu Thr Arg Gln Met Leu Thr Thr Asp Asp Asp Leu His Glu 
            500                 505                 510         


Ala Arg Lys Thr Leu Phe Asn Val Thr Asp Ser Trp Arg Pro Pro Ala 
        515                 520                 525             


Asp Pro Ile Gly Glu Pro Leu Gly Asn Pro Ser Val Asp Arg Val Leu 
    530                 535                 540                 


Lys Asn Val Asn Arg Tyr Leu Met Asn Cys Gln Gln Arg Trp Gly Asn 
545                 550                 555                 560 


Pro Val Ser Val Asn Ile Glu His Val Arg Ser Ser Phe Ser Ser Val 
                565                 570                 575     


Ala Phe Ala Arg Lys Asp Lys Arg Glu Tyr Glu Lys Asn Asn Glu Lys 
            580                 585                 590         


Arg Ser Ile Phe Arg Ser Ser Leu Ser Glu Gln Leu Arg Ala Asp Glu 
        595                 600                 605             


Gln Met Glu Lys Val Arg Glu Ser Asp Leu Arg Arg Leu Glu Ala Ile 
    610                 615                 620                 


Gln Arg Gln Asn Gly Gln Cys Leu Tyr Cys Gly Arg Thr Ile Thr Phe 
625                 630                 635                 640 


Arg Thr Cys Glu Met Asp His Ile Val Pro Arg Lys Gly Val Gly Ser 
                645                 650                 655     


Thr Asn Thr Arg Thr Asn Phe Ala Ala Val Cys Ala Glu Cys Asn Arg 
            660                 665                 670         


Met Lys Ser Asn Thr Pro Phe Ala Ile Trp Ala Arg Ser Glu Asp Ala 
        675                 680                 685             


Gln Thr Arg Gly Val Ser Leu Ala Glu Ala Lys Lys Arg Val Thr Met 
    690                 695                 700                 


Phe Thr Phe Asn Pro Lys Ser Tyr Ala Pro Arg Glu Val Lys Ala Phe 
705                 710                 715                 720 


Lys Gln Ala Val Ile Ala Arg Leu Gln Gln Thr Glu Asp Asp Ala Ala 
                725                 730                 735     


Ile Asp Asn Arg Ser Ile Glu Ser Val Ala Trp Met Ala Asp Glu Leu 
            740                 745                 750         


His Arg Arg Ile Asp Trp Tyr Phe Asn Ala Lys Gln Tyr Val Asn Ser 
        755                 760                 765             


Ala Ser Ile Asp Asp Ala Glu Ala Glu Thr Met Lys Thr Thr Val Ser 
    770                 775                 780                 


Val Phe Gln Gly Arg Val Thr Ala Ser Ala Arg Arg Ala Ala Gly Ile 
785                 790                 795                 800 


Glu Gly Lys Ile His Phe Ile Gly Gln Gln Ser Lys Thr Arg Leu Asp 
                805                 810                 815     


Arg Arg His His Ala Val Asp Ala Ser Val Ile Ala Met Met Asn Thr 
            820                 825                 830         


Ala Ala Ala Gln Thr Leu Met Glu Arg Glu Ser Leu Arg Glu Ser Gln 
        835                 840                 845             


Arg Leu Ile Gly Leu Met Pro Gly Glu Arg Ser Trp Lys Glu Tyr Pro 
    850                 855                 860                 


Tyr Glu Gly Thr Ser Arg Tyr Glu Ser Phe His Leu Trp Leu Asp Asn 
865                 870                 875                 880 


Met Asp Val Leu Leu Glu Leu Leu Asn Asp Ala Leu Asp Asn Asp Arg 
                885                 890                 895     


Ile Ala Val Met Gln Ser Gln Arg Tyr Val Leu Gly Asn Ser Ile Ala 
            900                 905                 910         


His Asp Ala Thr Ile His Pro Leu Glu Lys Val Pro Leu Gly Ser Ala 
        915                 920                 925             


Met Ser Ala Asp Leu Ile Arg Arg Ala Ser Thr Pro Ala Leu Trp Cys 
    930                 935                 940                 


Ala Leu Thr Arg Leu Pro Asp Tyr Asp Glu Lys Glu Gly Leu Pro Glu 
945                 950                 955                 960 


Asp Ser His Arg Glu Ile Arg Val His Asp Thr Arg Tyr Ser Ala Asp 
                965                 970                 975     


Asp Glu Met Gly Phe Phe Ala Ser Gln Ala Ala Gln Ile Ala Val Gln 
            980                 985                 990         


Glu Gly Ser Ala Asp Ile Gly Ser  Ala Ile His His Ala  Arg Val Tyr 
        995                 1000                 1005             


Arg Cys  Trp Lys Thr Asn Ala  Lys Gly Val Arg Lys  Tyr Phe Tyr 
    1010                 1015                 1020             


Gly Met  Ile Arg Val Phe Gln  Thr Asp Leu Leu Arg  Ala Cys His 
    1025                 1030                 1035             


Asp Asp  Leu Phe Thr Val Pro  Leu Pro Pro Gln Ser  Ile Ser Met 
    1040                 1045                 1050             


Arg Tyr  Gly Glu Pro Arg Val  Val Gln Ala Leu Gln  Ser Gly Asn 
    1055                 1060                 1065             


Ala Gln  Tyr Leu Gly Ser Leu  Val Val Gly Asp Glu  Ile Glu Met 
    1070                 1075                 1080             


Asp Phe  Pro Val Ser Met Leu  Met Val Arg Leu Ala  Ser Ile Tyr 
    1085                 1090                 1095             


Asn Ser  Ser Arg Ser Leu Val  Glu Gly Thr Leu His  Gly Asn Ile 
    1100                 1105                 1110             


Gly Leu  Leu Met Asp Ser Leu  Thr Arg Arg Ser 
    1115                 1120                 


<210> 98
<211> 1138
<212> PRT
<213> Bifidobacterium sp.

<400> 98
Met Asn Ser Val Gly Leu Ala Ala Val Glu Val Ser Asp Glu Asn Ser 
1               5                   10                  15      


Pro Val Arg Leu Leu Asn Ala Gln Ser Val Ile His Asp Gly Gly Val 
            20                  25                  30          


Asp Pro Gln Lys Asn Lys Glu Ala Ile Thr Arg Lys Asn Met Ser Gly 
        35                  40                  45              


Val Ala Arg Arg Thr Arg Arg Met Arg Arg Arg Lys Arg Glu Arg Leu 
    50                  55                  60                  


His Lys Leu Asp Met Leu Leu Gly Lys Phe Gly Tyr Pro Val Ile Glu 
65                  70                  75                  80  


Pro Glu Ser Leu Asp Lys Pro Phe Glu Glu Trp His Val Arg Ala Glu 
                85                  90                  95      


Leu Ala Thr Arg Tyr Ile Glu Asp Asp Glu Leu Arg Arg Glu Ser Ile 
            100                 105                 110         


Ser Ile Ala Leu Arg His Met Ala Arg His Arg Gly Trp Arg Asn Pro 
        115                 120                 125             


Tyr Arg Gln Val Asp Ser Leu Ile Ser Asp Asn Pro Tyr Ser Lys Gln 
    130                 135                 140                 


Tyr Gly Glu Leu Lys Glu Lys Ala Lys Ala Tyr Asn Asp Asp Ala Thr 
145                 150                 155                 160 


Ala Ala Glu Glu Glu Ser Thr Pro Ala Gln Leu Val Val Ala Met Leu 
                165                 170                 175     


Asp Ala Gly Tyr Ala Glu Ala Pro Arg Leu Arg Trp Arg Thr Gly Ser 
            180                 185                 190         


Lys Lys Pro Asp Ala Glu Gly Tyr Leu Pro Val Arg Leu Met Gln Glu 
        195                 200                 205             


Asp Asn Ala Asn Glu Leu Lys Gln Ile Phe Arg Val Gln Arg Val Pro 
    210                 215                 220                 


Ala Asp Glu Trp Lys Pro Leu Phe Arg Ser Val Phe Tyr Ala Val Ser 
225                 230                 235                 240 


Pro Lys Gly Ser Ala Glu Gln Arg Val Gly Gln Asp Pro Leu Ala Pro 
                245                 250                 255     


Glu Gln Ala Arg Ala Leu Lys Ala Ser Leu Ala Phe Gln Glu Tyr Arg 
            260                 265                 270         


Ile Ala Asn Val Ile Thr Asn Leu Arg Ile Lys Asp Ala Ser Ala Glu 
        275                 280                 285             


Leu Arg Lys Leu Thr Val Asp Glu Lys Gln Ser Ile Tyr Asp Gln Leu 
    290                 295                 300                 


Val Ser Pro Ser Ser Glu Asp Ile Thr Trp Ser Asp Leu Cys Asp Phe 
305                 310                 315                 320 


Leu Gly Phe Lys Arg Ser Gln Leu Lys Gly Val Gly Ser Leu Thr Glu 
                325                 330                 335     


Asp Gly Glu Glu Arg Ile Ser Ser Arg Pro Pro Arg Leu Thr Ser Val 
            340                 345                 350         


Gln Arg Ile Tyr Glu Ser Asp Asn Lys Ile Arg Lys Pro Leu Val Ala 
        355                 360                 365             


Trp Trp Lys Ser Ala Ser Asp Asn Glu His Glu Ala Met Ile Arg Leu 
    370                 375                 380                 


Leu Ser Asn Thr Val Asp Ile Asp Lys Val Arg Glu Asp Val Ala Tyr 
385                 390                 395                 400 


Ala Ser Ala Ile Glu Phe Ile Asp Gly Leu Asp Asp Asp Ala Leu Thr 
                405                 410                 415     


Lys Leu Asp Ser Val Asp Leu Pro Ser Gly Arg Ala Ala Tyr Ser Val 
            420                 425                 430         


Glu Thr Leu Gln Lys Leu Thr Arg Gln Met Leu Thr Thr Asp Asp Asp 
        435                 440                 445             


Leu His Glu Ala Arg Lys Thr Leu Phe Asn Val Thr Asp Ser Trp Arg 
    450                 455                 460                 


Pro Pro Ala Asp Pro Ile Gly Glu Pro Leu Gly Asn Pro Ser Val Asp 
465                 470                 475                 480 


Arg Val Leu Lys Asn Val Asn Arg Tyr Leu Met Asn Cys Gln Gln Arg 
                485                 490                 495     


Trp Gly Asn Pro Val Ser Val Asn Ile Glu His Val Arg Ser Ser Phe 
            500                 505                 510         


Ser Ser Val Ala Phe Ala Arg Lys Asp Lys Arg Glu Tyr Glu Lys Asn 
        515                 520                 525             


Asn Glu Lys Arg Ser Ile Phe Arg Ser Ser Leu Ser Glu Gln Leu Arg 
    530                 535                 540                 


Ala Asp Glu Gln Met Glu Lys Val Arg Glu Ser Asp Leu Arg Arg Leu 
545                 550                 555                 560 


Glu Ala Ile Gln Arg Gln Asn Gly Gln Cys Leu Tyr Cys Gly Arg Thr 
                565                 570                 575     


Ile Thr Phe Arg Thr Cys Glu Met Asp His Ile Val Pro Arg Lys Gly 
            580                 585                 590         


Val Gly Ser Thr Asn Thr Arg Thr Asn Phe Ala Ala Val Cys Ala Glu 
        595                 600                 605             


Cys Asn Arg Met Lys Ser Asn Thr Pro Phe Ala Ile Trp Ala Arg Ser 
    610                 615                 620                 


Glu Asp Ala Gln Thr Arg Gly Val Ser Leu Ala Glu Ala Lys Lys Arg 
625                 630                 635                 640 


Val Thr Met Phe Thr Phe Asn Pro Lys Ser Tyr Ala Pro Arg Glu Val 
                645                 650                 655     


Lys Ala Phe Lys Gln Ala Val Ile Ala Arg Leu Gln Gln Thr Glu Asp 
            660                 665                 670         


Asp Ala Ala Ile Asp Asn Arg Ser Ile Glu Ser Val Ala Trp Met Ala 
        675                 680                 685             


Asp Glu Leu His Arg Arg Ile Asp Trp Tyr Phe Asn Ala Lys Gln Tyr 
    690                 695                 700                 


Val Asn Ser Ala Ser Ile Asp Asp Ala Glu Ala Glu Thr Met Lys Thr 
705                 710                 715                 720 


Thr Val Ser Val Phe Gln Gly Arg Val Thr Ala Ser Ala Arg Arg Ala 
                725                 730                 735     


Ala Gly Ile Glu Gly Lys Ile His Phe Ile Gly Gln Gln Ser Lys Thr 
            740                 745                 750         


Arg Leu Asp Arg Arg His His Ala Val Asp Ala Ser Val Ile Ala Met 
        755                 760                 765             


Met Asn Thr Ala Ala Ala Gln Thr Leu Met Glu Arg Glu Ser Leu Arg 
    770                 775                 780                 


Glu Ser Gln Arg Leu Ile Gly Leu Met Pro Gly Glu Arg Ser Trp Lys 
785                 790                 795                 800 


Glu Tyr Pro Tyr Glu Gly Thr Ser Arg Tyr Glu Ser Phe His Leu Trp 
                805                 810                 815     


Leu Asp Asn Met Asp Val Leu Leu Glu Leu Leu Asn Asp Ala Leu Asp 
            820                 825                 830         


Asn Asp Arg Ile Ala Val Met Gln Ser Gln Arg Tyr Val Leu Gly Asn 
        835                 840                 845             


Ser Ile Ala His Asp Ala Thr Ile His Pro Leu Glu Lys Val Pro Leu 
    850                 855                 860                 


Gly Ser Ala Met Ser Ala Asp Leu Ile Arg Arg Ala Ser Thr Pro Ala 
865                 870                 875                 880 


Leu Trp Cys Ala Leu Thr Arg Leu Pro Asp Tyr Asp Glu Lys Glu Gly 
                885                 890                 895     


Leu Pro Glu Asp Ser His Arg Glu Ile Arg Val His Asp Thr Arg Tyr 
            900                 905                 910         


Ser Ala Asp Asp Glu Met Gly Phe Phe Ala Ser Gln Ala Ala Gln Ile 
        915                 920                 925             


Ala Val Gln Glu Gly Ser Ala Asp Ile Gly Ser Ala Ile His His Ala 
    930                 935                 940                 


Arg Val Tyr Arg Cys Trp Lys Thr Asn Ala Lys Gly Val Arg Lys Tyr 
945                 950                 955                 960 


Phe Tyr Gly Met Ile Arg Val Phe Gln Thr Asp Leu Leu Arg Ala Cys 
                965                 970                 975     


His Asp Asp Leu Phe Thr Val Pro Leu Pro Pro Gln Ser Ile Ser Met 
            980                 985                 990         


Arg Tyr Gly Glu Pro Arg Val Val  Gln Ala Leu Gln Ser  Gly Asn Ala 
        995                 1000                 1005             


Gln Tyr  Leu Gly Ser Leu Val  Val Gly Asp Glu Ile  Glu Met Asp 
    1010                 1015                 1020             


Phe Ser  Ser Leu Asp Val Asp  Gly Gln Ile Gly Glu  Tyr Leu Gln 
    1025                 1030                 1035             


Phe Phe  Ser Gln Phe Ser Gly  Gly Asn Leu Ala Trp  Lys His Trp 
    1040                 1045                 1050             


Val Val  Asp Gly Phe Phe Asn  Gln Thr Gln Leu Arg  Ile Arg Pro 
    1055                 1060                 1065             


Arg Tyr  Leu Ala Ala Glu Gly  Leu Ala Lys Ala Phe  Ser Asp Asp 
    1070                 1075                 1080             


Val Val  Pro Asp Gly Val Gln  Lys Ile Val Thr Lys  Gln Gly Trp 
    1085                 1090                 1095             


Leu Pro  Pro Val Asn Thr Ala  Ser Lys Thr Ala Val  Arg Ile Val 
    1100                 1105                 1110             


Arg Arg  Asn Ala Phe Gly Glu  Pro Arg Leu Ser Ser  Ala His His 
    1115                 1120                 1125             


Met Pro  Cys Ser Trp Gln Trp  Arg His Glu 
    1130                 1135             


<210> 99
<211> 1151
<212> PRT
<213> Bifidobacterium sp.


<220>
<223> Bifidobacterium sp. 12_1_47BFAA

<400> 99
Met Arg Gly Lys Arg Tyr Arg Ile Gly Ile Asp Val Gly Leu Asn Ser 
1               5                   10                  15      


Val Gly Leu Ala Ala Val Glu Val Ser Asp Glu Asn Ser Pro Val Arg 
            20                  25                  30          


Leu Leu Asn Ala Gln Ser Val Ile His Asp Gly Gly Val Asp Pro Gln 
        35                  40                  45              


Lys Asn Lys Glu Ala Ile Thr Arg Lys Asn Met Ser Gly Val Ala Arg 
    50                  55                  60                  


Arg Thr Arg Arg Met Arg Arg Arg Lys Arg Glu Arg Leu His Lys Leu 
65                  70                  75                  80  


Asp Met Leu Leu Gly Lys Phe Gly Tyr Pro Val Ile Glu Pro Glu Ser 
                85                  90                  95      


Leu Asp Lys Pro Phe Glu Glu Trp His Val Arg Ala Glu Leu Ala Thr 
            100                 105                 110         


Arg Tyr Ile Glu Asp Asp Glu Leu Arg Arg Glu Ser Ile Ser Ile Ala 
        115                 120                 125             


Leu Arg His Met Ala Arg His Arg Gly Trp Arg Asn Pro Tyr Arg Gln 
    130                 135                 140                 


Val Asp Ser Leu Ile Ser Asp Asn Pro Tyr Ser Lys Gln Tyr Gly Glu 
145                 150                 155                 160 


Leu Lys Glu Lys Ala Lys Ala Tyr Asn Asp Asp Ala Thr Ala Ala Glu 
                165                 170                 175     


Glu Glu Ser Thr Pro Ala Gln Leu Val Val Ala Met Leu Asp Ala Gly 
            180                 185                 190         


Tyr Ala Glu Ala Pro Arg Leu Arg Trp Arg Thr Gly Ser Lys Lys Pro 
        195                 200                 205             


Asp Ala Glu Gly Tyr Leu Pro Val Arg Leu Met Gln Glu Asp Asn Ala 
    210                 215                 220                 


Asn Glu Leu Lys Gln Ile Phe Arg Val Gln Arg Val Pro Ala Asp Glu 
225                 230                 235                 240 


Trp Lys Pro Leu Phe Arg Ser Val Phe Tyr Ala Val Ser Pro Lys Gly 
                245                 250                 255     


Ser Ala Glu Gln Arg Val Gly Gln Asp Pro Leu Ala Pro Glu Gln Ala 
            260                 265                 270         


Arg Ala Leu Lys Ala Ser Leu Ala Phe Gln Glu Tyr Arg Ile Ala Asn 
        275                 280                 285             


Val Ile Thr Asn Leu Arg Ile Lys Asp Ala Ser Ala Glu Leu Arg Lys 
    290                 295                 300                 


Leu Thr Val Asp Glu Lys Gln Ser Ile Tyr Asp Gln Leu Val Ser Pro 
305                 310                 315                 320 


Ser Ser Glu Asp Ile Thr Trp Ser Asp Leu Cys Asp Phe Leu Gly Phe 
                325                 330                 335     


Lys Arg Ser Gln Leu Lys Gly Val Gly Ser Leu Thr Glu Asp Gly Glu 
            340                 345                 350         


Glu Arg Ile Ser Ser Arg Pro Pro Arg Leu Thr Ser Val Gln Arg Ile 
        355                 360                 365             


Tyr Glu Ser Asp Asn Lys Ile Arg Lys Pro Leu Val Ala Trp Trp Lys 
    370                 375                 380                 


Ser Ala Ser Asp Asn Glu His Glu Ala Met Ile Arg Leu Leu Ser Asn 
385                 390                 395                 400 


Thr Val Asp Ile Asp Lys Val Arg Glu Asp Val Ala Tyr Ala Ser Ala 
                405                 410                 415     


Ile Glu Phe Ile Asp Gly Leu Asp Asp Asp Ala Leu Thr Lys Leu Asp 
            420                 425                 430         


Ser Val Asp Leu Pro Ser Gly Arg Ala Ala Tyr Ser Val Glu Thr Leu 
        435                 440                 445             


Gln Lys Leu Thr Arg Gln Met Leu Thr Thr Asp Asp Asp Leu His Glu 
    450                 455                 460                 


Ala Arg Lys Thr Leu Phe Asn Val Thr Asp Ser Trp Arg Pro Pro Ala 
465                 470                 475                 480 


Asp Pro Ile Gly Glu Pro Leu Gly Asn Pro Ser Val Asp Arg Val Leu 
                485                 490                 495     


Lys Asn Val Asn Arg Tyr Leu Met Asn Cys Gln Gln Arg Trp Gly Asn 
            500                 505                 510         


Pro Val Ser Val Asn Ile Glu His Val Arg Ser Ser Phe Ser Ser Val 
        515                 520                 525             


Ala Phe Ala Arg Lys Asp Lys Arg Glu Tyr Glu Lys Asn Asn Glu Lys 
    530                 535                 540                 


Arg Ser Ile Phe Arg Ser Ser Leu Ser Glu Gln Leu Arg Ala Asp Glu 
545                 550                 555                 560 


Gln Met Glu Lys Val Arg Glu Ser Asp Leu Arg Arg Leu Glu Ala Ile 
                565                 570                 575     


Gln Arg Gln Asn Gly Gln Cys Leu Tyr Cys Gly Arg Thr Ile Thr Phe 
            580                 585                 590         


Arg Thr Cys Glu Met Asp His Ile Val Pro Arg Lys Gly Val Gly Ser 
        595                 600                 605             


Thr Asn Thr Arg Thr Asn Phe Ala Ala Val Cys Ala Glu Cys Asn Arg 
    610                 615                 620                 


Met Lys Ser Asn Thr Pro Phe Ala Ile Trp Ala Arg Ser Glu Asp Ala 
625                 630                 635                 640 


Gln Thr Arg Gly Val Ser Leu Ala Glu Ala Lys Lys Arg Val Thr Met 
                645                 650                 655     


Phe Thr Phe Asn Pro Lys Ser Tyr Ala Pro Arg Glu Val Lys Ala Phe 
            660                 665                 670         


Lys Gln Ala Val Ile Ala Arg Leu Gln Gln Thr Glu Asp Asp Ala Ala 
        675                 680                 685             


Ile Asp Asn Arg Ser Ile Glu Ser Val Ala Trp Met Ala Asp Glu Leu 
    690                 695                 700                 


His Arg Arg Ile Asp Trp Tyr Phe Asn Ala Lys Gln Tyr Val Asn Ser 
705                 710                 715                 720 


Ala Ser Ile Asp Asp Ala Glu Ala Glu Thr Met Lys Thr Thr Val Ser 
                725                 730                 735     


Val Phe Gln Gly Arg Val Thr Ala Ser Ala Arg Arg Ala Ala Gly Ile 
            740                 745                 750         


Glu Gly Lys Ile His Phe Ile Gly Gln Gln Ser Lys Thr Arg Leu Asp 
        755                 760                 765             


Arg Arg His His Ala Val Asp Ala Ser Val Ile Ala Met Met Asn Thr 
    770                 775                 780                 


Ala Ala Ala Gln Thr Leu Met Glu Arg Glu Ser Leu Arg Glu Ser Gln 
785                 790                 795                 800 


Arg Leu Ile Gly Leu Met Pro Gly Glu Arg Ser Trp Lys Glu Tyr Pro 
                805                 810                 815     


Tyr Glu Gly Thr Ser Arg Tyr Glu Ser Phe His Leu Trp Leu Asp Asn 
            820                 825                 830         


Met Asp Val Leu Leu Glu Leu Leu Asn Asp Ala Leu Asp Asn Asp Arg 
        835                 840                 845             


Ile Ala Val Met Gln Ser Gln Arg Tyr Val Leu Gly Asn Ser Ile Ala 
    850                 855                 860                 


His Asp Ala Thr Ile His Pro Leu Glu Lys Val Pro Leu Gly Ser Ala 
865                 870                 875                 880 


Met Ser Ala Asp Leu Ile Arg Arg Ala Ser Thr Pro Ala Leu Trp Cys 
                885                 890                 895     


Ala Leu Thr Arg Leu Pro Asp Tyr Asp Glu Lys Glu Gly Leu Pro Glu 
            900                 905                 910         


Asp Ser His Arg Glu Ile Arg Val His Asp Thr Arg Tyr Ser Ala Asp 
        915                 920                 925             


Asp Glu Met Gly Phe Phe Ala Ser Gln Ala Ala Gln Ile Ala Val Gln 
    930                 935                 940                 


Glu Gly Ser Ala Asp Ile Gly Ser Ala Ile His His Ala Arg Val Tyr 
945                 950                 955                 960 


Arg Cys Trp Lys Thr Asn Ala Lys Gly Val Arg Lys Tyr Phe Tyr Gly 
                965                 970                 975     


Met Ile Arg Val Phe Gln Thr Asp Leu Leu Arg Ala Cys His Asp Asp 
            980                 985                 990         


Leu Phe Thr Val Pro Leu Pro Pro  Gln Ser Ile Ser Met  Arg Tyr Gly 
        995                 1000                 1005             


Glu Pro  Arg Val Val Gln Ala  Leu Gln Ser Gly Asn  Ala Gln Tyr 
    1010                 1015                 1020             


Leu Gly  Ser Leu Val Val Gly  Asp Glu Ile Glu Met  Asp Phe Ser 
    1025                 1030                 1035             


Ser Leu  Asp Val Asp Gly Gln  Ile Gly Glu Tyr Leu  Gln Phe Phe 
    1040                 1045                 1050             


Ser Gln  Phe Ser Gly Gly Asn  Leu Ala Trp Lys His  Trp Val Val 
    1055                 1060                 1065             


Asp Gly  Phe Phe Asn Gln Thr  Gln Leu Arg Ile Arg  Pro Arg Tyr 
    1070                 1075                 1080             


Leu Ala  Ala Glu Gly Leu Ala  Lys Ala Phe Ser Asp  Asp Val Val 
    1085                 1090                 1095             


Pro Asp  Gly Val Gln Lys Ile  Val Thr Lys Gln Gly  Trp Leu Pro 
    1100                 1105                 1110             


Pro Val  Asn Thr Ala Ser Lys  Thr Ala Val Arg Ile  Val Arg Arg 
    1115                 1120                 1125             


Asn Ala  Phe Gly Glu Pro Arg  Leu Ser Ser Ala His  His Met Pro 
    1130                 1135                 1140             


Cys Ser  Trp Gln Trp Arg His  Glu 
    1145                 1150     


<210> 100
<211> 1092
<212> PRT
<213> Brevibacillus laterosporus


<220>
<223> Brevibacillus laterosporus GI-9

<400> 100
Met Ala Tyr Thr Met Gly Ile Asp Val Gly Ile Ala Ser Cys Gly Trp 
1               5                   10                  15      


Ala Ile Val Asp Leu Glu Arg Gln Arg Ile Ile Asp Ile Gly Val Arg 
            20                  25                  30          


Thr Phe Glu Lys Ala Glu Asn Pro Lys Asn Gly Glu Ala Leu Ala Val 
        35                  40                  45              


Pro Arg Arg Glu Ala Arg Ser Ser Arg Arg Arg Leu Arg Arg Lys Lys 
    50                  55                  60                  


His Arg Ile Glu Arg Leu Lys Tyr Met Phe Val Arg Asn Gly Leu Ala 
65                  70                  75                  80  


Val Asp Ile Gln His Leu Glu Gln Thr Leu Arg Ser Gln Asn Glu Ile 
                85                  90                  95      


Asp Val Trp Gln Leu Arg Val Asp Gly Leu Asp Arg Met Leu Thr Gln 
            100                 105                 110         


Lys Glu Trp Leu Arg Val Leu Ile His Leu Ala Gln Arg Arg Gly Phe 
        115                 120                 125             


Gln Ser Asn Arg Lys Thr Asp Gly Ser Ser Glu Asp Gly Gln Val Leu 
    130                 135                 140                 


Val Asn Val Thr Glu Asn Asp Arg Leu Met Glu Glu Lys Asp Tyr Arg 
145                 150                 155                 160 


Thr Val Ala Glu Met Met Val Lys Asp Glu Lys Phe Ser Asp His Lys 
                165                 170                 175     


Arg Asn Lys Asn Gly Asn Tyr His Gly Val Val Ser Arg Ala Ser Leu 
            180                 185                 190         


Leu Val Glu Ile His Thr Leu Phe Glu Ser Gln Arg Gln His His Asn 
        195                 200                 205             


Phe Leu Ala Ser Lys Asp Phe Glu Leu Glu Tyr Ile Asn Ile Trp Ser 
    210                 215                 220                 


Ser Gln Arg Pro Val Ala Thr Lys Asp Gln Ile Glu Lys Met Ile Gly 
225                 230                 235                 240 


Thr Cys Thr Phe Leu Pro Lys Glu Lys Arg Ala Pro Lys Ala Ser Trp 
                245                 250                 255     


His Phe Gln Tyr Phe Met Leu Leu Gln Thr Ile Asn His Ile Arg Ile 
            260                 265                 270         


Thr Asn Ala Gln Gly Thr Arg Pro Leu Asn Lys Glu Glu Ile Glu Gln 
        275                 280                 285             


Val Val Asn Met Ala Leu Thr Lys Ser Lys Val Ser Tyr His Asp Ile 
    290                 295                 300                 


Arg Lys Val Leu Asp Leu Ser Glu Glu Tyr Gln Phe Val Gly Leu Asp 
305                 310                 315                 320 


Tyr Gly Lys Glu Asp Glu Lys Lys Lys Val Glu Ser Lys Glu Thr Ile 
                325                 330                 335     


Ile Lys Leu Asp Asp Tyr His Lys Leu Asn Lys Ile Phe Asn Glu Val 
            340                 345                 350         


Glu Leu Ala Lys Gly Glu Thr Trp Glu Ala Val Asp Tyr Asp Thr Val 
        355                 360                 365             


Ala Tyr Ala Leu Thr Phe Phe Lys Asp Asp Glu Asp Ile Arg Asp Tyr 
    370                 375                 380                 


Leu Gln Asn Lys Tyr Lys Asp Ser Lys Asn Arg Leu Val Lys Asn Val 
385                 390                 395                 400 


Ala Asn Lys Glu Tyr Thr Asn Glu Leu Ile Glu Lys Val Ser Thr Leu 
                405                 410                 415     


Ser Phe Arg Lys Val Gly His Leu Ser Leu Lys Ala Leu Arg Lys Ile 
            420                 425                 430         


Ile Pro Phe Leu Glu Gln Gly Met Thr Tyr Asp Lys Ala Cys Gln Ala 
        435                 440                 445             


Ala Gly Phe Asn Phe Gln Gly Ile Ser Lys Lys Lys Arg Ser Val Val 
    450                 455                 460                 


Leu Pro Val Ile Asp Gln Ile Ser Asn Pro Val Val Asn Arg Ala Leu 
465                 470                 475                 480 


Thr Gln Thr Arg Lys Val Ile Asn Ala Leu Ile Lys Lys Tyr Gly Ser 
                485                 490                 495     


Pro Glu Thr Ile His Ile Glu Thr Ala Arg Glu Leu Ser Lys Arg Phe 
            500                 505                 510         


Asp Glu Arg Lys Asn Ile Thr Lys Asp Tyr Lys Glu Asn Arg Asp Lys 
        515                 520                 525             


Asn Glu Arg Ala Lys Lys His Leu Ser Glu Leu Gly Ile Ile Asn Pro 
    530                 535                 540                 


Thr Gly Leu Asp Ile Val Lys Tyr Lys Leu Trp Cys Glu Gln Gln Gly 
545                 550                 555                 560 


Arg Cys Met Tyr Ser Asn Gln Pro Ile Ser Phe Glu Arg Leu Arg Glu 
                565                 570                 575     


Ser Gly Tyr Thr Glu Val Asp His Ile Ile Pro Tyr Ser Arg Ser Met 
            580                 585                 590         


Asn Asp Ser Tyr Asn Asn Arg Val Leu Val Met Thr Arg Glu Asn Arg 
        595                 600                 605             


Glu Lys Ser Asn Gln Thr Pro Tyr Glu Tyr Met Gly Asn Asp Thr Gln 
    610                 615                 620                 


Arg Trp Asp Glu Phe Glu Gln Arg Val Thr Thr Asn Pro Gln Ile Lys 
625                 630                 635                 640 


Lys Glu Lys Arg Gln Asn Leu Leu Leu Lys Gly Phe Thr Asn Arg Arg 
                645                 650                 655     


Glu Leu Glu Met Leu Glu Arg Asn Leu Asn Asp Thr Arg His Ile Thr 
            660                 665                 670         


Lys Tyr Leu Ser His Phe Ile Ser Thr Asn Leu Glu Phe Ser Pro Ser 
        675                 680                 685             


Asp Lys Lys Lys Lys Val Val Asn Thr Ser Gly Arg Ile Thr Ser His 
    690                 695                 700                 


Leu Arg Ser Arg Trp Gly Leu Glu Lys Asn Arg Glu Gln Asn Asp Leu 
705                 710                 715                 720 


His His Ala Met Asp Ala Val Val Ile Ala Val Thr Ser Asp Ser Phe 
                725                 730                 735     


Ile Gln Gln Val Thr Asn Tyr Tyr Lys Arg Lys Glu Arg Arg Glu Leu 
            740                 745                 750         


Asn Gly Asp Asp Lys Phe Pro Leu Pro Trp Lys Phe Phe Arg Glu Glu 
        755                 760                 765             


Val Ile Ala Arg Leu Ser Pro Asn Pro Lys Glu Gln Ile Glu Ala Leu 
    770                 775                 780                 


Pro Asn His Phe Tyr Ser Glu Asp Glu Leu Ala Asp Leu Gln Pro Ile 
785                 790                 795                 800 


Phe Val Ser Arg Met Pro Lys Arg Ser Ile Thr Gly Glu Ala His Gln 
                805                 810                 815     


Ala Gln Phe Arg Arg Val Val Gly Lys Thr Lys Glu Gly Lys Asn Ile 
            820                 825                 830         


Thr Ala Lys Lys Thr Ala Leu Val Asp Ile Ser Tyr Asp Lys Asn Gly 
        835                 840                 845             


Asp Phe Asn Met Tyr Gly Arg Glu Thr Asp Pro Ala Thr Tyr Glu Ala 
    850                 855                 860                 


Ile Lys Glu Arg Tyr Leu Glu Phe Gly Gly Asn Ala Lys Lys Ala Phe 
865                 870                 875                 880 


Ser Thr Asp Leu His Lys Pro Lys Lys Asp Gly Thr Lys Gly Pro Leu 
                885                 890                 895     


Ile Lys Ser Val Arg Ile Met Glu Asn Lys Thr Leu Val His Pro Val 
            900                 905                 910         


Asn Lys Gly Lys Gly Val Val Tyr Asn Ser Ser Ile Val Arg Thr Asp 
        915                 920                 925             


Val Phe Gln Arg Lys Glu Lys Tyr Tyr Leu Leu Pro Val Tyr Val Thr 
    930                 935                 940                 


Asp Val Thr Lys Gly Lys Leu Pro Asn Lys Val Ile Ala Ala Lys Lys 
945                 950                 955                 960 


Gly Tyr Asp Asp Trp Ile Glu Val Asp Asp Ser Phe Thr Phe Leu Tyr 
                965                 970                 975     


Ser Leu Tyr Pro Asn Asp Leu Ile Phe Ile Arg Gln Asn Pro Lys Lys 
            980                 985                 990         


Lys Ile Ser Leu Lys Lys Arg Ile  Glu Ser His Ser Ile  Ser Asp Ser 
        995                 1000                 1005             


Lys Glu  Val Gln Glu Ile Leu  Thr Tyr Tyr Lys Gly  Val Asp Ser 
    1010                 1015                 1020             


Ser Thr  Ala Ala Ile Glu Phe  Ile Thr His Asp Gly  Ser Tyr Tyr 
    1025                 1030                 1035             


Ala Lys  Gly Val Gly Val Gln  Asn Leu Asp Cys Phe  Glu Lys Tyr 
    1040                 1045                 1050             


Gln Val  Asp Ile Leu Gly Asn  Tyr Ser Lys Val Lys  Gly Glu Lys 
    1055                 1060                 1065             


Arg Leu  Glu Leu Glu Thr Ser  Asp Asn Asn His Lys  Gly Lys Asp 
    1070                 1075                 1080             


Val Asn  Ser Ile Lys Ser Thr  Ser Arg 
    1085                 1090         


<210> 101
<211> 1428
<212> PRT
<213> Burkholderiales bacterium


<220>
<223> Burkholderiales bacterium 1_1_47

<400> 101
Met Gly Lys Thr His Ile Ile Gly Val Gly Leu Asp Leu Gly Gly Thr 
1               5                   10                  15      


Tyr Thr Gly Thr Phe Ile Thr Ser His Pro Ser Asp Glu Ala Glu His 
            20                  25                  30          


Arg Asp His Ser Ser Ala Phe Thr Val Val Asn Ser Glu Lys Leu Ser 
        35                  40                  45              


Phe Ser Ser Lys Ser Arg Thr Ala Val Arg His Arg Val Arg Ser Tyr 
    50                  55                  60                  


Lys Gly Phe Asp Leu Arg Arg Arg Leu Leu Leu Leu Val Ala Glu Tyr 
65                  70                  75                  80  


Gln Leu Leu Gln Lys Lys Gln Thr Leu Ala Pro Glu Glu Arg Glu Asn 
                85                  90                  95      


Leu Arg Ile Ala Leu Ser Gly Tyr Leu Lys Arg Lys Gly Tyr Ala Arg 
            100                 105                 110         


Thr Glu Ala Glu Thr Asp Thr Ser Val Leu Glu Ser Leu Asp Pro Ser 
        115                 120                 125             


Val Phe Ser Ser Ala Pro Ser Phe Thr Asn Phe Phe Asn Asp Ser Glu 
    130                 135                 140                 


Pro Leu Asn Ile Gln Trp Glu Ala Ile Ala Asn Ser Pro Glu Thr Thr 
145                 150                 155                 160 


Lys Ala Leu Asn Lys Glu Leu Ser Gly Gln Lys Glu Ala Asp Phe Lys 
                165                 170                 175     


Lys Tyr Ile Lys Thr Ser Phe Pro Glu Tyr Ser Ala Lys Glu Ile Leu 
            180                 185                 190         


Ala Asn Tyr Val Glu Gly Arg Arg Ala Ile Leu Asp Ala Ser Lys Tyr 
        195                 200                 205             


Ile Ala Asn Leu Gln Ser Leu Gly His Lys His Arg Ser Lys Tyr Leu 
    210                 215                 220                 


Ser Asp Ile Leu Gln Asp Met Lys Arg Asp Ser Arg Ile Thr Arg Leu 
225                 230                 235                 240 


Ser Glu Ala Phe Gly Ser Thr Asp Asn Leu Trp Arg Ile Ile Gly Asn 
                245                 250                 255     


Ile Ser Asn Leu Gln Glu Arg Ala Val Arg Trp Tyr Phe Asn Asp Ala 
            260                 265                 270         


Lys Phe Glu Gln Gly Gln Glu Gln Leu Asp Ala Val Lys Leu Lys Asn 
        275                 280                 285             


Val Leu Val Arg Ala Leu Lys Tyr Leu Arg Ser Asp Asp Lys Glu Trp 
    290                 295                 300                 


Ser Ala Ser Gln Lys Gln Ile Ile Gln Ser Leu Glu Gln Ser Gly Asp 
305                 310                 315                 320 


Val Leu Asp Val Leu Ala Gly Leu Asp Pro Asp Arg Thr Ile Pro Pro 
                325                 330                 335     


Tyr Glu Asp Gln Asn Asn Arg Arg Pro Pro Glu Asp Gln Thr Leu Tyr 
            340                 345                 350         


Leu Asn Pro Lys Ala Leu Ser Ser Glu Tyr Gly Glu Lys Trp Lys Ser 
        355                 360                 365             


Trp Ala Asn Lys Phe Ala Gly Ala Tyr Pro Leu Leu Thr Glu Asp Leu 
    370                 375                 380                 


Thr Glu Ile Leu Lys Asn Thr Asp Arg Lys Ser Arg Ile Lys Ile Arg 
385                 390                 395                 400 


Ser Asp Val Leu Pro Asp Ser Asp Tyr Arg Leu Ala Tyr Ile Leu Gln 
                405                 410                 415     


Arg Ala Phe Asp Arg Ser Ile Ala Leu Asp Glu Cys Ser Ile Arg Arg 
            420                 425                 430         


Thr Ala Glu Asp Phe Glu Asn Gly Val Val Ile Lys Asn Glu Lys Leu 
        435                 440                 445             


Glu Asp Val Leu Ser Gly His Gln Leu Glu Glu Phe Leu Glu Phe Ala 
    450                 455                 460                 


Asn Arg Tyr Tyr Gln Glu Thr Ala Lys Ala Lys Asn Gly Leu Trp Phe 
465                 470                 475                 480 


Pro Glu Asn Ala Leu Leu Glu Arg Ala Asp Leu His Pro Pro Met Lys 
                485                 490                 495     


Asn Lys Ile Leu Asn Val Ile Val Gly Gln Ala Leu Gly Val Ser Pro 
            500                 505                 510         


Ala Glu Gly Thr Asp Phe Ile Glu Glu Ile Trp Asn Ser Lys Val Lys 
        515                 520                 525             


Gly Arg Ser Thr Val His Ser Ile Cys Asn Ala Ile Glu Asn Glu Arg 
    530                 535                 540                 


Lys Thr Tyr Gly Pro Tyr Phe Ser Glu Asp Tyr Lys Phe Val Lys Thr 
545                 550                 555                 560 


Ala Leu Lys Glu Gly Lys Thr Glu Lys Glu Leu Ser Lys Lys Phe Ala 
                565                 570                 575     


Ala Val Ile Lys Val Leu Lys Met Val Ser Glu Val Val Pro Phe Ile 
            580                 585                 590         


Gly Lys Glu Leu Arg Leu Ser Asp Glu Ala Gln Ser Lys Phe Asp Asn 
        595                 600                 605             


Pro Tyr Ser Leu Ala Gln Leu Tyr Asn Leu Ile Glu Thr Glu Arg Asn 
    610                 615                 620                 


Gly Phe Ser Lys Val Ser Leu Ala Ala His Leu Glu Asn Ala Trp Arg 
625                 630                 635                 640 


Met Thr Met Thr Asp Gly Ser Ala Gln Cys Cys Arg Leu Pro Ala Asp 
                645                 650                 655     


Cys Val Arg Pro Phe Asp Gly Phe Ile Arg Lys Ala Ile Asp Arg Asn 
            660                 665                 670         


Ser Trp Glu Val Ala Lys Arg Ile Ala Glu Glu Val Lys Lys Ser Val 
        675                 680                 685             


Asp Phe Thr Asn Gly Thr Val Lys Ile Pro Val Ala Ile Glu Ala Asn 
    690                 695                 700                 


Ser Phe Asn Phe Thr Ala Ser Leu Thr Asp Leu Lys Tyr Ile Gln Leu 
705                 710                 715                 720 


Lys Glu Gln Lys Leu Lys Lys Lys Leu Glu Asp Ile Gln Arg Asn Glu 
                725                 730                 735     


Glu Asn Gln Glu Lys Arg Trp Leu Ser Lys Glu Glu Arg Ile Arg Ala 
            740                 745                 750         


Asp Ser His Gly Ile Cys Ala Tyr Thr Gly Arg Pro Leu Asp Asp Val 
        755                 760                 765             


Gly Glu Ile Asp His Ile Ile Pro Arg Ser Leu Thr Leu Lys Lys Ser 
    770                 775                 780                 


Glu Ser Ile Tyr Asn Ser Glu Val Asn Leu Ile Phe Val Ser Ala Gln 
785                 790                 795                 800 


Gly Asn Gln Glu Lys Lys Asn Asn Ile Tyr Leu Leu Ser Asn Leu Ala 
                805                 810                 815     


Lys Asn Tyr Leu Ala Ala Val Phe Gly Ala Ser Asp Leu Ser Gln Ile 
            820                 825                 830         


Thr Asn Glu Ile Glu Ser Thr Val Leu Gln Leu Lys Ala Ala Gly Arg 
        835                 840                 845             


Leu Gly Tyr Phe Asp Leu Leu Ser Glu Lys Glu Arg Ala Cys Ala Arg 
    850                 855                 860                 


His Ala Leu Phe Leu Asn Ser Asp Ser Glu Ala Arg Arg Ala Val Ile 
865                 870                 875                 880 


Asp Val Leu Gly Ser Arg Arg Lys Ala Ser Val Asn Gly Thr Gln Ala 
                885                 890                 895     


Trp Phe Val Arg Ser Ile Phe Ser Lys Val Arg Gln Ala Leu Ala Ala 
            900                 905                 910         


Trp Thr Gln Glu Thr Gly Asn Glu Leu Ile Phe Asp Ala Ile Ser Val 
        915                 920                 925             


Pro Ala Ala Asp Ser Ser Glu Met Arg Lys Arg Phe Ala Glu Tyr Arg 
    930                 935                 940                 


Pro Glu Phe Arg Lys Pro Lys Val Gln Pro Val Ala Ser His Ser Ile 
945                 950                 955                 960 


Asp Ala Met Cys Ile Tyr Leu Ala Ala Cys Ser Asp Pro Phe Lys Thr 
                965                 970                 975     


Lys Arg Met Gly Ser Gln Leu Ala Ile Tyr Glu Pro Ile Asn Phe Asp 
            980                 985                 990         


Asn Leu Phe Thr Gly Ser Cys Gln  Val Ile Gln Asn Thr  Pro Arg Asn 
        995                 1000                 1005             


Phe Ser  Asp Lys Thr Asn Ile  Ala Asn Ser Pro Ile  Phe Lys Glu 
    1010                 1015                 1020             


Thr Ile  Tyr Ala Glu Arg Phe  Leu Asp Ile Ile Val  Ser Arg Gly 
    1025                 1030                 1035             


Glu Ile  Phe Ile Gly Tyr Pro  Ser Asn Met Pro Phe  Glu Glu Lys 
    1040                 1045                 1050             


Pro Asn  Arg Ile Ser Ile Gly  Gly Lys Asp Pro Phe  Ser Ile Leu 
    1055                 1060                 1065             


Ser Val  Leu Gly Ala Tyr Leu  Asp Lys Ala Pro Ser  Ser Glu Lys 
    1070                 1075                 1080             


Glu Lys  Leu Thr Ile Tyr Arg  Val Val Lys Asn Lys  Ala Phe Glu 
    1085                 1090                 1095             


Leu Phe  Ser Lys Val Ala Gly  Ser Lys Phe Thr Ala  Glu Glu Asp 
    1100                 1105                 1110             


Lys Ala  Ala Lys Ile Leu Glu  Ala Leu His Phe Val  Thr Val Lys 
    1115                 1120                 1125             


Gln Asp  Val Ala Ala Thr Val  Ser Asp Leu Ile Lys  Ser Lys Lys 
    1130                 1135                 1140             


Glu Leu  Ser Lys Asp Ser Ile  Glu Asn Leu Ala Lys  Gln Lys Gly 
    1145                 1150                 1155             


Cys Leu  Lys Lys Val Glu Tyr  Ser Ser Lys Glu Phe  Lys Phe Lys 
    1160                 1165                 1170             


Gly Ser  Leu Ile Ile Pro Ala  Ala Val Glu Trp Gly  Lys Val Leu 
    1175                 1180                 1185             


Trp Asn  Val Phe Lys Glu Asn  Thr Ala Glu Glu Leu  Lys Asp Glu 
    1190                 1195                 1200             


Asn Ala  Leu Arg Lys Ala Leu  Glu Ala Ala Trp Pro  Ser Ser Phe 
    1205                 1210                 1215             


Gly Thr  Arg Asn Leu His Ser  Lys Ala Lys Arg Val  Phe Ser Leu 
    1220                 1225                 1230             


Pro Val  Val Ala Thr Gln Ser  Gly Ala Val Arg Ile  Arg Arg Lys 
    1235                 1240                 1245             


Thr Ala  Phe Gly Asp Phe Val  Tyr Gln Ser Gln Asp  Thr Asn Asn 
    1250                 1255                 1260             


Leu Tyr  Ser Ser Phe Pro Val  Lys Asn Gly Lys Leu  Asp Trp Ser 
    1265                 1270                 1275             


Ser Pro  Ile Ile His Pro Ala  Leu Gln Asn Arg Asn  Leu Thr Ala 
    1280                 1285                 1290             


Tyr Gly  Tyr Arg Phe Val Asp  His Asp Arg Ser Ile  Ser Met Ser 
    1295                 1300                 1305             


Glu Phe  Arg Glu Val Tyr Asn  Lys Asp Asp Leu Met  Arg Ile Glu 
    1310                 1315                 1320             


Leu Ala  Gln Gly Thr Ser Ser  Arg Arg Tyr Leu Arg  Val Glu Met 
    1325                 1330                 1335             


Pro Gly  Glu Lys Phe Leu Ala  Trp Phe Gly Glu Asn  Ser Ile Ser 
    1340                 1345                 1350             


Leu Gly  Ser Ser Phe Lys Phe  Ser Val Ser Glu Val  Phe Asp Asn 
    1355                 1360                 1365             


Lys Ile  Tyr Thr Glu Asn Ala  Glu Phe Thr Lys Phe  Leu Pro Lys 
    1370                 1375                 1380             


Pro Arg  Glu Asp Asn Lys His  Asn Gly Thr Ile Phe  Phe Glu Leu 
    1385                 1390                 1395             


Val Gly  Pro Arg Val Ile Phe  Asn Tyr Ile Val Gly  Gly Ala Ala 
    1400                 1405                 1410             


Ser Ser  Leu Lys Glu Ile Phe  Ser Glu Ala Gly Lys  Glu Arg Ser 
    1415                 1420                 1425             


<210> 102
<211> 1442
<212> PRT
<213> Caenispirillum salinarum


<220>
<223> Caenispirillum salinarum AK4

<400> 102
Met Pro Val Leu Ser Pro Leu Ser Pro Asn Ala Ala Gln Gly Arg Arg 
1               5                   10                  15      


Arg Trp Ser Leu Ala Leu Asp Ile Gly Glu Gly Ser Ile Gly Trp Ala 
            20                  25                  30          


Val Ala Glu Val Asp Ala Glu Gly Arg Val Leu Gln Leu Thr Gly Thr 
        35                  40                  45              


Gly Val Thr Leu Phe Pro Ser Ala Trp Ser Asn Glu Asn Gly Thr Tyr 
    50                  55                  60                  


Val Ala His Gly Ala Ala Asp Arg Ala Val Arg Gly Gln Gln Gln Arg 
65                  70                  75                  80  


His Asp Ser Arg Arg Arg Arg Leu Ala Gly Leu Ala Arg Leu Cys Ala 
                85                  90                  95      


Pro Val Leu Glu Arg Ser Pro Glu Asp Leu Lys Asp Leu Thr Arg Thr 
            100                 105                 110         


Pro Pro Lys Ala Asp Pro Arg Ala Ile Phe Phe Leu Arg Ala Asp Ala 
        115                 120                 125             


Ala Arg Arg Pro Leu Asp Gly Pro Glu Leu Phe Arg Val Leu His His 
    130                 135                 140                 


Met Ala Ala His Arg Gly Ile Arg Leu Ala Glu Leu Gln Glu Val Asp 
145                 150                 155                 160 


Pro Pro Pro Glu Ser Asp Ala Asp Asp Ala Ala Pro Ala Ala Thr Glu 
                165                 170                 175     


Asp Glu Asp Gly Thr Arg Arg Ala Ala Ala Asp Glu Arg Ala Phe Arg 
            180                 185                 190         


Arg Leu Met Ala Glu His Met His Arg His Gly Thr Gln Pro Thr Cys 
        195                 200                 205             


Gly Glu Ile Met Ala Gly Arg Leu Arg Glu Thr Pro Ala Gly Ala Gln 
    210                 215                 220                 


Pro Val Thr Arg Ala Arg Asp Gly Leu Arg Val Gly Gly Gly Val Ala 
225                 230                 235                 240 


Val Pro Thr Arg Ala Leu Ile Glu Gln Glu Phe Asp Ala Ile Arg Ala 
                245                 250                 255     


Ile Gln Ala Pro Arg His Pro Asp Leu Pro Trp Asp Ser Leu Arg Arg 
            260                 265                 270         


Leu Val Leu Asp Gln Ala Pro Ile Ala Val Pro Pro Ala Thr Pro Cys 
        275                 280                 285             


Leu Phe Leu Glu Glu Leu Arg Arg Arg Gly Glu Thr Phe Gln Gly Arg 
    290                 295                 300                 


Thr Ile Thr Arg Glu Ala Ile Asp Arg Gly Leu Thr Val Asp Pro Leu 
305                 310                 315                 320 


Ile Gln Ala Leu Arg Ile Arg Glu Thr Val Gly Asn Leu Arg Leu His 
                325                 330                 335     


Glu Arg Ile Thr Glu Pro Asp Gly Arg Gln Arg Tyr Val Pro Arg Ala 
            340                 345                 350         


Met Pro Glu Leu Gly Leu Ser His Gly Glu Leu Thr Ala Pro Glu Arg 
        355                 360                 365             


Asp Thr Leu Val Arg Ala Leu Met His Asp Pro Asp Gly Leu Ala Ala 
    370                 375                 380                 


Lys Asp Gly Arg Ile Pro Tyr Thr Arg Leu Arg Lys Leu Ile Gly Tyr 
385                 390                 395                 400 


Asp Asn Ser Pro Val Cys Phe Ala Gln Glu Arg Asp Thr Ser Gly Gly 
                405                 410                 415     


Gly Ile Thr Val Asn Pro Thr Asp Pro Leu Met Ala Arg Trp Ile Asp 
            420                 425                 430         


Gly Trp Val Asp Leu Pro Leu Lys Ala Arg Ser Leu Tyr Val Arg Asp 
        435                 440                 445             


Val Val Ala Arg Gly Ala Asp Ser Ala Ala Leu Ala Arg Leu Leu Ala 
    450                 455                 460                 


Glu Gly Ala His Gly Val Pro Pro Val Ala Ala Ala Ala Val Pro Ala 
465                 470                 475                 480 


Ala Thr Ala Ala Ile Leu Glu Ser Asp Ile Met Gln Pro Gly Arg Tyr 
                485                 490                 495     


Ser Val Cys Pro Trp Ala Ala Glu Ala Ile Leu Asp Ala Trp Ala Asn 
            500                 505                 510         


Ala Pro Thr Glu Gly Phe Tyr Asp Val Thr Arg Gly Leu Phe Gly Phe 
        515                 520                 525             


Ala Pro Gly Glu Ile Val Leu Glu Asp Leu Arg Arg Ala Arg Gly Ala 
    530                 535                 540                 


Leu Leu Ala His Leu Pro Arg Thr Met Ala Ala Ala Arg Thr Pro Asn 
545                 550                 555                 560 


Arg Ala Ala Gln Gln Arg Gly Pro Leu Pro Ala Tyr Glu Ser Val Ile 
                565                 570                 575     


Pro Ser Gln Leu Ile Thr Ser Leu Arg Arg Ala His Lys Gly Arg Ala 
            580                 585                 590         


Ala Asp Trp Ser Ala Ala Asp Pro Glu Glu Arg Asn Pro Phe Leu Arg 
        595                 600                 605             


Thr Trp Thr Gly Asn Ala Ala Thr Asp His Ile Leu Asn Gln Val Arg 
    610                 615                 620                 


Lys Thr Ala Asn Glu Val Ile Thr Lys Tyr Gly Asn Arg Arg Gly Trp 
625                 630                 635                 640 


Asp Pro Leu Pro Ser Arg Ile Thr Val Glu Leu Ala Arg Glu Ala Lys 
                645                 650                 655     


His Gly Val Ile Arg Arg Asn Glu Ile Ala Lys Glu Asn Arg Glu Asn 
            660                 665                 670         


Glu Gly Arg Arg Lys Lys Glu Ser Ala Ala Leu Asp Thr Phe Cys Gln 
        675                 680                 685             


Asp Asn Thr Val Ser Trp Gln Ala Gly Gly Leu Pro Lys Glu Arg Ala 
    690                 695                 700                 


Ala Leu Arg Leu Arg Leu Ala Gln Arg Gln Glu Phe Phe Cys Pro Tyr 
705                 710                 715                 720 


Cys Ala Glu Arg Pro Lys Leu Arg Ala Thr Asp Leu Phe Ser Pro Ala 
                725                 730                 735     


Glu Thr Glu Ile Asp His Val Ile Glu Arg Arg Met Gly Gly Asp Gly 
            740                 745                 750         


Pro Asp Asn Leu Val Leu Ala His Lys Asp Cys Asn Asn Ala Lys Gly 
        755                 760                 765             


Lys Lys Thr Pro His Glu His Ala Gly Asp Leu Leu Asp Ser Pro Ala 
    770                 775                 780                 


Leu Ala Ala Leu Trp Gln Gly Trp Arg Lys Glu Asn Ala Asp Arg Leu 
785                 790                 795                 800 


Lys Gly Lys Gly His Lys Ala Arg Thr Pro Arg Glu Asp Lys Asp Phe 
                805                 810                 815     


Met Asp Arg Val Gly Trp Arg Phe Glu Glu Asp Ala Arg Ala Lys Ala 
            820                 825                 830         


Glu Glu Asn Gln Glu Arg Arg Gly Arg Arg Met Leu His Asp Thr Ala 
        835                 840                 845             


Arg Ala Thr Arg Leu Ala Arg Leu Tyr Leu Ala Ala Ala Val Met Pro 
    850                 855                 860                 


Glu Asp Pro Ala Glu Ile Gly Ala Pro Pro Val Glu Thr Pro Pro Ser 
865                 870                 875                 880 


Pro Glu Asp Pro Thr Gly Tyr Thr Ala Ile Tyr Arg Thr Ile Ser Arg 
                885                 890                 895     


Val Gln Pro Val Asn Gly Ser Val Thr His Met Leu Arg Gln Arg Leu 
            900                 905                 910         


Leu Gln Arg Asp Lys Asn Arg Asp Tyr Gln Thr His His Ala Glu Asp 
        915                 920                 925             


Ala Cys Leu Leu Leu Leu Ala Gly Pro Ala Val Val Gln Ala Phe Asn 
    930                 935                 940                 


Thr Glu Ala Ala Gln His Gly Ala Asp Ala Pro Asp Asp Arg Pro Val 
945                 950                 955                 960 


Asp Leu Met Pro Thr Ser Asp Ala Tyr His Gln Gln Arg Arg Ala Arg 
                965                 970                 975     


Ala Leu Gly Arg Val Pro Leu Ala Thr Val Asp Ala Ala Leu Ala Asp 
            980                 985                 990         


Ile Val Met Pro Glu Ser Asp Arg  Gln Asp Pro Glu Thr  Gly Arg Val 
        995                 1000                 1005             


His Trp  Arg Leu Thr Arg Ala  Gly Arg Gly Leu Lys  Arg Arg Ile 
    1010                 1015                 1020             


Asp Asp  Leu Thr Arg Asn Cys  Val Ile Leu Ser Arg  Pro Arg Arg 
    1025                 1030                 1035             


Pro Ser  Glu Thr Gly Thr Pro  Gly Ala Leu His Asn  Ala Thr His 
    1040                 1045                 1050             


Tyr Gly  Arg Arg Glu Ile Thr  Val Asp Gly Arg Thr  Asp Thr Val 
    1055                 1060                 1065             


Val Thr  Gln Arg Met Asn Ala  Arg Asp Leu Val Ala  Leu Leu Asp 
    1070                 1075                 1080             


Asn Ala  Lys Ile Val Pro Ala  Ala Arg Leu Asp Ala  Ala Ala Pro 
    1085                 1090                 1095             


Gly Asp  Thr Ile Leu Lys Glu  Ile Cys Thr Glu Ile  Ala Asp Arg 
    1100                 1105                 1110             


His Asp  Arg Val Val Asp Pro  Glu Gly Thr His Ala  Arg Arg Trp 
    1115                 1120                 1125             


Ile Ser  Ala Arg Leu Ala Ala  Leu Val Pro Ala His  Ala Glu Ala 
    1130                 1135                 1140             


Val Ala  Arg Asp Ile Ala Glu  Leu Ala Asp Leu Asp  Ala Leu Ala 
    1145                 1150                 1155             


Asp Ala  Asp Arg Thr Pro Glu  Gln Glu Ala Arg Arg  Ser Ala Leu 
    1160                 1165                 1170             


Arg Gln  Ser Pro Tyr Leu Gly  Arg Ala Ile Ser Ala  Lys Lys Ala 
    1175                 1180                 1185             


Asp Gly  Arg Ala Arg Ala Arg  Glu Gln Glu Ile Leu  Thr Arg Ala 
    1190                 1195                 1200             


Leu Leu  Asp Pro His Trp Gly  Pro Arg Gly Leu Arg  His Leu Ile 
    1205                 1210                 1215             


Met Arg  Glu Ala Arg Ala Pro  Ser Leu Val Arg Ile  Arg Ala Asn 
    1220                 1225                 1230             


Lys Thr  Asp Ala Phe Gly Arg  Pro Val Pro Asp Ala  Ala Val Trp 
    1235                 1240                 1245             


Val Lys  Thr Asp Gly Asn Ala  Val Ser Gln Leu Trp  Arg Leu Thr 
    1250                 1255                 1260             


Ser Val  Val Thr Asp Asp Gly  Arg Arg Ile Pro Leu  Pro Lys Pro 
    1265                 1270                 1275             


Ile Glu  Lys Arg Ile Glu Ile  Ser Asn Leu Glu Tyr  Ala Arg Leu 
    1280                 1285                 1290             


Asn Gly  Leu Asp Glu Gly Ala  Gly Val Thr Gly Asn  Asn Ala Pro 
    1295                 1300                 1305             


Pro Arg  Pro Leu Arg Gln Asp  Ile Asp Arg Leu Thr  Pro Leu Trp 
    1310                 1315                 1320             


Arg Asp  His Gly Thr Ala Pro  Gly Gly Tyr Leu Gly  Thr Ala Val 
    1325                 1330                 1335             


Gly Glu  Leu Glu Asp Lys Ala  Arg Ser Ala Leu Arg  Gly Lys Ala 
    1340                 1345                 1350             


Met Arg  Gln Thr Leu Thr Asp  Ala Gly Ile Thr Ala  Glu Ala Gly 
    1355                 1360                 1365             


Trp Arg  Leu Asp Ser Glu Gly  Ala Val Cys Asp Leu  Glu Val Ala 
    1370                 1375                 1380             


Lys Gly  Asp Thr Val Lys Lys  Asp Gly Lys Thr Tyr  Lys Val Gly 
    1385                 1390                 1395             


Val Ile  Thr Gln Gly Ile Phe  Gly Met Pro Val Asp  Ala Ala Gly 
    1400                 1405                 1410             


Ser Ala  Pro Arg Thr Pro Glu  Asp Cys Glu Lys Phe  Glu Glu Gln 
    1415                 1420                 1425             


Tyr Gly  Ile Lys Pro Trp Lys  Ala Lys Gly Ile Pro  Leu Ala 
    1430                 1435                 1440         


<210> 103
<211> 984
<212> PRT
<213> Campylobacter coli


<220>
<223> Campylobacter coli 1098

<400> 103
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Ser Glu 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Val Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Gln Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn Tyr Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asn Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 104
<211> 984
<212> PRT
<213> Campylobacter coli


<220>
<223> Campylobacter coli 111-3

<400> 104
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Ser Glu 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Val Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Gln Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Thr Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asn Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Tyr Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Leu Val Tyr Phe Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 105
<211> 987
<212> PRT
<213> Campylobacter coli


<220>
<223> Campylobacter coli 132-6

<400> 105
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Ser Glu 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Val Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Gln Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Thr Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asn Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Tyr Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Leu Val Tyr Phe Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Asn Glu Leu Arg 
            980                 985         


<210> 106
<211> 984
<212> PRT
<213> Campylobacter coli


<220>
<223> Campylobacter coli 151-9

<400> 106
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Ser Glu 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Val Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Gln Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Thr Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asn Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Tyr Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asn Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Leu Val Tyr Phe Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 107
<211> 984
<212> PRT
<213> Campylobacter coli


<220>
<223> Campylobacter coli 1909

<400> 107
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Cys Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Ser Glu 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Val Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Gln Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asn Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 108
<211> 965
<212> PRT
<213> Campylobacter coli


<220>
<223> Campylobacter coli 1957

<400> 108
Met Lys Ile Ile Gly Phe Asn Leu Gly Ile Ala Asn Ile Gly Trp Ala 
1               5                   10                  15      


Leu Arg Glu Asn Asp Glu Ile Ile Asp Cys Gly Val Arg Val Phe Asp 
            20                  25                  30          


Ile Pro Glu Asn Pro Lys Asn Gly Asn Ser Leu Ala Leu Glu Arg Arg 
        35                  40                  45              


Glu Asn Lys Ala Arg Met Lys Ile Val Lys Arg Lys Lys Ala Arg Met 
    50                  55                  60                  


Leu Ala Thr Lys Thr Phe Leu Lys Lys Glu Leu Asn Val Asp Leu Ser 
65                  70                  75                  80  


Lys Leu Phe Leu Ile Gly Ser Thr Gln Ser Ile Tyr Glu Leu Arg Thr 
                85                  90                  95      


Lys Ala Leu Ser Ser Leu Ile Ser Lys Glu Glu Leu Ser Ala Ile Ile 
            100                 105                 110         


Leu His Ile Ala Lys His Arg Gly Tyr Asp Asp Ser Ala Leu Lys Asn 
        115                 120                 125             


Glu Asn Gly Thr Ile Ile Glu Ala Leu Asn Lys Asn Lys Glu Ala Met 
    130                 135                 140                 


Leu Lys Phe Lys Ser Val Gly Glu Tyr Phe Tyr Lys Asn Phe Val Gln 
145                 150                 155                 160 


Asn Lys Glu Val Lys Lys Ile Arg Asn Thr Thr Glu Asp Tyr Ser Asn 
                165                 170                 175     


Ser Val Pro Arg Ser Leu Leu Lys Gln Glu Leu Asp Leu Ile Leu Asp 
            180                 185                 190         


Lys Gln Lys Glu Leu Gly Leu Ile Lys Asn Ala Asp Phe Lys Glu Lys 
        195                 200                 205             


Leu Phe Glu Ile Ile Phe Phe Lys Arg Pro Leu Lys Asp Phe Ser Asn 
    210                 215                 220                 


Lys Ile Gly Asn Cys Ile Phe Phe Glu Asn Glu Lys Arg Ala Ala Lys 
225                 230                 235                 240 


Asn Thr Ile Ser Ala Cys Glu Phe Val Ala Leu Gly Lys Val Val Asn 
                245                 250                 255     


Leu Leu Lys Ser Ile Glu Lys Asp Ile Gly Ile Val Tyr Glu Lys Asp 
            260                 265                 270         


Ser Ile Asn Glu Ile Met Ser Ile Ile Leu Asp Lys Thr Ser Ile Ser 
        275                 280                 285             


Tyr Lys Lys Ile Arg Asp Ile Leu Asn Leu Pro Gln Asp Ile Asn Phe 
    290                 295                 300                 


Lys Gly Leu Asp Tyr Ser Lys Asn Asn Ala Glu Asn Ser Lys Leu Val 
305                 310                 315                 320 


Asp Leu Lys Lys Leu Asn Glu Phe Lys Lys Ala Leu Gly Asp Gly Phe 
                325                 330                 335     


Ala Asn Leu Asp Lys Asp Ile Leu Asp Ser Ile Ala Thr Asp Ile Thr 
            340                 345                 350         


Leu Thr Lys Asp Thr Ala Thr Leu Lys Glu Lys Leu Lys Asn Tyr Asn 
        355                 360                 365             


Val Leu Asn Ala Glu Gln Ile Glu Lys Leu Ser Glu Leu Val Phe Asn 
    370                 375                 380                 


Asp His Ile Asn Leu Ser Leu Lys Ala Leu Lys Gln Ile Ile Pro Leu 
385                 390                 395                 400 


Met Tyr Glu Gly Lys Arg Tyr Asp Glu Ala Cys Glu Leu Cys Asn Phe 
                405                 410                 415     


Thr Ile Ala Lys Asn Gln Glu Lys Asn Glu Tyr Leu Pro Leu Phe Glu 
            420                 425                 430         


Lys Thr Arg Phe Ala Lys Asp Ile Ser Ser Pro Val Val Ile Arg Ala 
        435                 440                 445             


Ile Cys Glu Phe Arg Lys Leu Leu Asn Asp Ile Ile Arg Arg Tyr Gly 
    450                 455                 460                 


Ser Val His Lys Ile His Leu Glu Leu Thr Arg Asp Phe Gly Ile Ser 
465                 470                 475                 480 


Phe Asn Asp Arg Lys Lys Ile Ile Lys Glu Ile Glu Gln Asn Glu Gln 
                485                 490                 495     


Ser Arg Ile Lys Ala Leu Glu Thr Ile Lys Glu Leu Lys Leu Glu Glu 
            500                 505                 510         


Thr Ser Lys Asn Ile Gln Ile Val Arg Leu Phe Glu Asp Gln Lys Gly 
        515                 520                 525             


Ile Cys Pro Tyr Ser Gly Leu Lys Met Asp Leu Lys Cys Leu Asp Glu 
    530                 535                 540                 


Leu Val Ile Asp Tyr Ile Arg Pro Tyr Asn Arg Ser Leu Asp Asp Ser 
545                 550                 555                 560 


Tyr Ser Asn Lys Ile Leu Thr Phe Lys Lys Leu Asn Asp Leu Lys Gln 
                565                 570                 575     


Gly Lys Thr Pro Phe Glu Ala Phe Gly Glu Asp Glu Lys Leu Trp Ala 
            580                 585                 590         


Glu Ile Asn Glu Arg Ile Lys Glu Tyr Asn Gly Lys Lys Arg Phe Lys 
        595                 600                 605             


Ile Phe Asp Lys Phe Phe Lys Asp Lys Lys Pro Phe Asp Phe Thr Glu 
    610                 615                 620                 


Gln Thr Leu Gln Asp Thr Arg Trp Leu Thr Lys Leu Val Ala Ser Tyr 
625                 630                 635                 640 


Leu Asn Glu Tyr Leu Leu Phe Leu Pro Ile Asn Glu Asp Glu Asn Thr 
                645                 650                 655     


Ala Leu Gly Tyr Gly Glu Lys Gly Ser Lys Gln His Val Val Leu Ser 
            660                 665                 670         


Ser Gly Met Ile Thr Gln Met Leu Arg Asn Phe Trp Tyr Leu Gly Phe 
        675                 680                 685             


Lys Asn His Lys Asp Tyr Lys Asn Asn Ala Met Asp Ala Ile Ile Val 
    690                 695                 700                 


Ala Phe Thr Thr Asn Ser Ile Ile Phe Ala Phe Asn Asn Phe Lys Lys 
705                 710                 715                 720 


Glu Leu Asp Leu Ala Lys Ala Glu Phe Tyr Ala Asn Lys Ile Ser Glu 
                725                 730                 735     


Ser Asp Tyr Leu Leu Lys Arg Lys Phe Leu Pro Pro Phe Ser Gly Phe 
            740                 745                 750         


Lys Glu Gln Ala Leu Glu Lys Val Lys Asn Ile Phe Val Ser His Ser 
        755                 760                 765             


Leu Lys Ile Lys Asn Lys Gly Thr Leu His Glu Leu Thr Pro Leu Lys 
    770                 775                 780                 


Ile Lys Glu Leu Lys Asn Thr Tyr Gly Asp Leu Asp Leu Ala Val Lys 
785                 790                 795                 800 


Leu Gly Lys Ile Arg Lys Tyr Asn Asp Lys Tyr Tyr Ala Asn Ala Lys 
                805                 810                 815     


Gly Ser Leu Val Arg Thr Asp Leu Phe Ala Asp Lys Glu Asn Lys Phe 
            820                 825                 830         


His Ala Val Ser Ile Tyr Lys Ala Asp Phe Ser Thr Lys Lys Leu Pro 
        835                 840                 845             


Asn Lys Thr Pro Ala Thr Thr Ser Asn Gly Glu Thr Lys Glu Gly Ile 
    850                 855                 860                 


Glu Met Asn Glu Asn Tyr Asn Phe Cys Met Ser Leu Tyr Lys Asn Thr 
865                 870                 875                 880 


Pro Ile Ser Val Lys Ile Lys Gly Met Lys Glu Pro Ile Ile Cys Tyr 
                885                 890                 895     


Tyr His Gly Phe Asn Thr Ser Gly Ser Lys Ile Thr Tyr Lys Lys His 
            900                 905                 910         


Asp Asn Asn Tyr His Asn Leu Ser Glu Asp Glu Met Val Val Phe Arg 
        915                 920                 925             


Lys Asn Asp Lys Glu Ser Ile Val Val Gly Lys Ile Leu Glu Ile Lys 
    930                 935                 940                 


Lys Tyr Ser Ile Ser Pro Ser Gly Glu Leu Ser Leu Ile Glu Asn Glu 
945                 950                 955                 960 


Glu Arg Lys Trp Phe 
                965 


<210> 109
<211> 984
<212> PRT
<213> Campylobacter coli


<220>
<223> Campylobacter coli 2692

<400> 109
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Thr Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Asp His Ser Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn Tyr Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 110
<211> 984
<212> PRT
<213> Campylobacter coli


<220>
<223> Campylobacter coli 59-2

<400> 110
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Gly Lys 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Val Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Thr Gln Ser Phe Leu Lys Tyr Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Gln Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Ser Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn Tyr Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asn Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 111
<211> 965
<212> PRT
<213> Campylobacter coli


<220>
<223> Campylobacter coli 67-8

<400> 111
Met Lys Ile Ile Gly Phe Asn Leu Gly Ile Ala Asn Ile Gly Trp Ala 
1               5                   10                  15      


Leu Arg Glu Asn Asp Glu Ile Ile Asp Cys Gly Val Arg Val Phe Asp 
            20                  25                  30          


Ile Pro Glu Asn Pro Lys Asn Gly Asn Ser Leu Ala Leu Glu Arg Arg 
        35                  40                  45              


Glu Asn Lys Ala Arg Met Lys Ile Val Lys Arg Lys Lys Ala Arg Met 
    50                  55                  60                  


Leu Ala Thr Lys Thr Phe Leu Lys Lys Glu Leu Asn Val Asp Leu Ser 
65                  70                  75                  80  


Lys Leu Phe Leu Ile Gly Ser Thr Gln Ser Ile Tyr Glu Leu Arg Thr 
                85                  90                  95      


Lys Ala Leu Ser Ser Leu Ile Ser Lys Glu Glu Leu Ser Ala Ile Ile 
            100                 105                 110         


Leu His Ile Ala Lys His Arg Gly Tyr Asp Asp Ser Ala Leu Lys Asn 
        115                 120                 125             


Glu Asn Gly Thr Ile Ile Glu Ala Leu Asn Lys Asn Lys Glu Ala Met 
    130                 135                 140                 


Leu Lys Phe Lys Ser Val Gly Glu Tyr Phe Tyr Lys Asn Phe Val Gln 
145                 150                 155                 160 


Asn Lys Glu Val Lys Lys Ile Arg Asn Thr Thr Glu Asp Tyr Ser Asn 
                165                 170                 175     


Ser Val Pro Arg Ser Leu Leu Lys Gln Glu Leu Asp Leu Ile Leu Asp 
            180                 185                 190         


Lys Gln Lys Glu Leu Gly Leu Ile Lys Asn Ala Asp Phe Lys Ala Lys 
        195                 200                 205             


Leu Phe Glu Ile Ile Phe Phe Lys Arg Pro Leu Lys Asp Phe Ser Asn 
    210                 215                 220                 


Lys Ile Gly Asn Cys Ile Phe Phe Glu Asn Glu Lys Arg Ala Ala Lys 
225                 230                 235                 240 


Asn Thr Ile Ser Ala Cys Glu Phe Val Ala Leu Gly Lys Val Val Asn 
                245                 250                 255     


Leu Leu Lys Ser Ile Glu Lys Asp Ile Gly Ile Val Tyr Glu Lys Asp 
            260                 265                 270         


Ser Ile Asn Glu Ile Met Ser Ile Ile Leu Asp Lys Thr Ser Ile Ser 
        275                 280                 285             


Tyr Lys Lys Ile Arg Asp Ile Leu Asn Leu Pro Gln Asp Ile Asn Phe 
    290                 295                 300                 


Lys Gly Leu Asp Tyr Ser Lys Asn Asn Ala Glu Asn Ser Lys Leu Val 
305                 310                 315                 320 


Asp Leu Lys Lys Leu Asn Glu Phe Lys Lys Ala Leu Gly Asp Gly Phe 
                325                 330                 335     


Ala Asn Leu Asp Lys Asp Ile Leu Asp Ser Ile Ala Thr Asp Ile Thr 
            340                 345                 350         


Leu Thr Lys Asp Thr Ala Thr Leu Lys Glu Lys Leu Lys Asn Tyr Asn 
        355                 360                 365             


Val Leu Asn Ala Glu Gln Ile Glu Lys Leu Ser Glu Leu Val Phe Asn 
    370                 375                 380                 


Asp His Ile Asn Leu Ser Leu Lys Ala Leu Lys Gln Ile Ile Pro Leu 
385                 390                 395                 400 


Met Tyr Glu Gly Lys Arg Tyr Asp Glu Ala Cys Glu Leu Cys Asn Phe 
                405                 410                 415     


Thr Ile Ala Lys Asn Gln Glu Lys Asn Glu Tyr Leu Pro Leu Phe Glu 
            420                 425                 430         


Lys Thr Arg Phe Ala Lys Asp Ile Ser Ser Pro Val Val Ile Arg Ala 
        435                 440                 445             


Ile Cys Glu Phe Arg Lys Leu Leu Asn Asp Ile Ile Arg Arg Tyr Gly 
    450                 455                 460                 


Ser Val His Lys Ile His Leu Glu Leu Thr Arg Asp Phe Gly Ile Ser 
465                 470                 475                 480 


Phe Asn Asp Arg Lys Lys Ile Ile Lys Glu Ile Glu Gln Asn Glu Gln 
                485                 490                 495     


Ser Arg Ile Lys Ala Leu Glu Thr Ile Lys Glu Leu Lys Leu Glu Glu 
            500                 505                 510         


Thr Ser Lys Asn Ile Gln Ile Val Arg Leu Phe Glu Asp Gln Lys Gly 
        515                 520                 525             


Ile Cys Pro Tyr Ser Gly Leu Lys Met Asp Leu Lys Cys Leu Asp Glu 
    530                 535                 540                 


Leu Val Ile Asp Tyr Ile Arg Pro Tyr Asn Arg Ser Leu Asp Asp Ser 
545                 550                 555                 560 


Tyr Ser Asn Lys Val Leu Thr Phe Lys Lys Leu Asn Asp Leu Lys Gln 
                565                 570                 575     


Gly Lys Thr Pro Phe Glu Ala Phe Gly Glu Asp Glu Lys Leu Trp Ala 
            580                 585                 590         


Glu Ile Asn Glu Arg Ile Lys Glu Tyr Asn Gly Lys Lys Arg Phe Lys 
        595                 600                 605             


Ile Phe Asp Lys Phe Phe Lys Asp Lys Lys Pro Phe Asp Phe Thr Glu 
    610                 615                 620                 


Gln Thr Leu Gln Asp Thr Arg Trp Leu Thr Lys Leu Val Ala Ser Tyr 
625                 630                 635                 640 


Leu Asn Glu Tyr Leu Ser Phe Leu Pro Ile Ser Glu Asp Glu Asn Thr 
                645                 650                 655     


Ala Leu Gly Tyr Gly Glu Lys Gly Ser Lys Gln His Val Val Leu Ser 
            660                 665                 670         


Ser Gly Met Ile Thr Gln Met Leu Arg Asn Phe Trp Tyr Leu Gly Phe 
        675                 680                 685             


Lys Asn His Lys Asn Tyr Lys Asn Asn Ala Met Asp Ala Ile Ile Val 
    690                 695                 700                 


Ala Phe Thr Thr Asn Ser Ile Ile Phe Ala Phe Asn Asn Phe Lys Lys 
705                 710                 715                 720 


Glu Leu Asp Leu Ala Lys Ala Glu Phe Tyr Ala Asn Lys Ile Ser Glu 
                725                 730                 735     


Ser Asp Tyr Leu Leu Lys Arg Lys Phe Leu Pro Pro Phe Ser Gly Phe 
            740                 745                 750         


Lys Glu Gln Ala Leu Glu Lys Val Lys Asn Ile Phe Val Ser His Ser 
        755                 760                 765             


Leu Lys Ile Lys Asn Lys Gly Thr Leu His Glu Leu Thr Pro Leu Lys 
    770                 775                 780                 


Ile Lys Glu Leu Lys Asn Thr Tyr Gly Asp Leu Asp Leu Ala Val Lys 
785                 790                 795                 800 


Leu Gly Lys Ile Arg Lys Tyr Asn Asp Lys Tyr Tyr Ala Asn Thr Lys 
                805                 810                 815     


Gly Ser Leu Val Arg Thr Asp Leu Phe Val Asp Lys Glu Asn Lys Phe 
            820                 825                 830         


His Ala Val Ser Ile Tyr Lys Ala Asp Phe Ser Thr Lys Lys Leu Pro 
        835                 840                 845             


Asn Lys Thr Pro Ala Thr Thr Ser Asn Gly Glu Thr Lys Glu Gly Ile 
    850                 855                 860                 


Glu Met Asn Glu Asn Tyr Asn Phe Cys Met Ser Leu Tyr Lys Asn Thr 
865                 870                 875                 880 


Pro Val Ser Val Lys Ile Lys Gly Met Lys Glu Pro Ile Ile Cys Tyr 
                885                 890                 895     


Tyr His Gly Phe Asn Thr Ser Gly Ser Lys Ile Thr Tyr Lys Lys His 
            900                 905                 910         


Asp Asn Asn Tyr His Asn Leu Ser Glu Asp Glu Met Val Val Phe Arg 
        915                 920                 925             


Lys Asn Asp Lys Glu Ser Ile Val Val Gly Lys Ile Leu Glu Ile Lys 
    930                 935                 940                 


Lys Tyr Ser Ile Ser Pro Ser Gly Glu Leu Ser Leu Ile Glu Asn Glu 
945                 950                 955                 960 


Lys Arg Lys Trp Phe 
                965 


<210> 112
<211> 965
<212> PRT
<213> Campylobacter coli


<220>
<223> Campylobacter coli 80352

<400> 112
Met Lys Ile Ile Gly Phe Asn Leu Gly Ile Ala Asn Ile Gly Trp Ala 
1               5                   10                  15      


Leu Arg Glu Asn Asp Glu Ile Ile Asp Cys Gly Val Arg Val Phe Asp 
            20                  25                  30          


Ile Pro Glu Asn Pro Lys Asn Gly Asn Ser Leu Ala Leu Glu Arg Arg 
        35                  40                  45              


Glu Asn Lys Ala Arg Met Lys Ile Val Lys Arg Lys Lys Ala Arg Met 
    50                  55                  60                  


Leu Ala Thr Lys Thr Phe Leu Lys Lys Glu Leu Asn Val Asp Leu Ser 
65                  70                  75                  80  


Lys Leu Phe Leu Ile Gly Ser Thr Gln Ser Ile Tyr Glu Leu Arg Thr 
                85                  90                  95      


Lys Ala Leu Ser Ser Leu Ile Ser Lys Glu Glu Leu Ser Ala Ile Ile 
            100                 105                 110         


Leu His Ile Ala Lys His Arg Gly Tyr Asp Asp Ser Ala Leu Lys Asn 
        115                 120                 125             


Glu Asn Gly Thr Ile Ile Glu Ala Leu Asn Lys Asn Lys Glu Ala Met 
    130                 135                 140                 


Leu Lys Phe Lys Ser Val Gly Glu Tyr Phe Tyr Lys Asn Phe Val Gln 
145                 150                 155                 160 


Asn Lys Glu Val Lys Lys Ile Arg Asn Thr Thr Glu Asp Tyr Ser Asn 
                165                 170                 175     


Ser Val Pro Arg Ser Leu Leu Lys Gln Glu Leu Asp Leu Ile Leu Asp 
            180                 185                 190         


Lys Gln Lys Glu Leu Gly Leu Ile Lys Asn Ala Asp Phe Lys Ala Lys 
        195                 200                 205             


Leu Phe Glu Ile Ile Phe Phe Lys Arg Pro Leu Lys Asp Phe Ser Asn 
    210                 215                 220                 


Lys Ile Gly Asn Cys Ile Phe Phe Glu Asn Glu Lys Arg Ala Ala Lys 
225                 230                 235                 240 


Asn Thr Ile Ser Ala Cys Glu Phe Val Ala Leu Gly Lys Val Val Asn 
                245                 250                 255     


Leu Leu Lys Ser Ile Glu Lys Asp Ile Gly Ile Val Tyr Glu Lys Asp 
            260                 265                 270         


Ser Ile Asn Glu Ile Met Ser Ile Ile Leu Asp Lys Thr Ser Ile Ser 
        275                 280                 285             


Tyr Lys Lys Ile Arg Asp Ile Leu Asn Leu Pro Gln Asp Ile Asn Phe 
    290                 295                 300                 


Lys Gly Leu Asp Tyr Ser Lys Asn Asn Val Glu Asn Ser Lys Leu Val 
305                 310                 315                 320 


Asp Leu Lys Lys Leu Asn Glu Phe Lys Lys Ala Leu Gly Asp Gly Phe 
                325                 330                 335     


Thr Asn Leu Asp Lys Asp Ile Leu Asp Ser Ile Ala Thr Asp Ile Thr 
            340                 345                 350         


Leu Thr Lys Asp Thr Ala Thr Leu Lys Glu Lys Leu Lys Asn Tyr Asn 
        355                 360                 365             


Val Leu Asn Ala Glu Gln Ile Glu Lys Leu Ser Glu Leu Val Phe Asn 
    370                 375                 380                 


Asp His Ile Asn Leu Ser Leu Lys Ala Leu Lys Gln Ile Ile Pro Leu 
385                 390                 395                 400 


Met Tyr Glu Gly Lys Arg Tyr Asp Glu Ala Cys Glu Leu Cys Asn Phe 
                405                 410                 415     


Thr Ile Ala Lys Asn Gln Glu Lys Asn Glu Tyr Leu Pro Leu Phe Glu 
            420                 425                 430         


Lys Thr Arg Phe Ala Lys Asp Ile Ser Ser Pro Val Val Ile Arg Ala 
        435                 440                 445             


Ile Cys Glu Phe Arg Lys Leu Leu Asn Asp Ile Ile Arg Arg Tyr Gly 
    450                 455                 460                 


Ser Val His Lys Ile His Leu Glu Leu Thr Arg Asp Phe Gly Ile Ser 
465                 470                 475                 480 


Phe Asn Asp Arg Lys Lys Ile Ile Lys Glu Ile Glu Gln Asn Glu Gln 
                485                 490                 495     


Ser Arg Ile Lys Ala Leu Glu Thr Ile Lys Glu Leu Lys Leu Glu Glu 
            500                 505                 510         


Thr Ser Lys Asn Ile Gln Ile Val Arg Leu Phe Glu Asp Gln Lys Gly 
        515                 520                 525             


Ile Cys Pro Tyr Ser Gly Leu Lys Met Asp Leu Lys Cys Leu Asp Glu 
    530                 535                 540                 


Leu Val Ile Asp Tyr Ile Arg Pro Tyr Asn Arg Ser Leu Asp Asp Ser 
545                 550                 555                 560 


Tyr Ser Asn Lys Val Leu Thr Phe Lys Lys Leu Asn Asp Leu Lys Gln 
                565                 570                 575     


Gly Lys Thr Pro Phe Glu Ala Phe Gly Glu Asp Glu Lys Leu Trp Ala 
            580                 585                 590         


Glu Ile Asn Glu Arg Ile Lys Glu Tyr Asn Gly Lys Lys Arg Phe Lys 
        595                 600                 605             


Ile Phe Asp Lys Phe Phe Lys Asp Lys Lys Pro Phe Asp Phe Thr Glu 
    610                 615                 620                 


Gln Thr Leu Gln Asp Thr Arg Trp Leu Thr Lys Leu Val Ala Ser Tyr 
625                 630                 635                 640 


Leu Asn Glu Tyr Leu Ser Phe Leu Pro Ile Ser Glu Asp Glu Asn Thr 
                645                 650                 655     


Ala Leu Gly Tyr Gly Glu Lys Gly Ser Lys Gln His Val Ile Leu Ser 
            660                 665                 670         


Ser Gly Met Ile Thr Gln Met Leu Arg Asn Phe Trp Tyr Leu Gly Phe 
        675                 680                 685             


Lys Asn His Lys Asp Tyr Lys Asn Asn Ala Met Asp Ala Ile Ile Val 
    690                 695                 700                 


Ala Phe Thr Thr Asn Ser Ile Ile Phe Thr Phe Asn Asn Phe Lys Lys 
705                 710                 715                 720 


Glu Leu Asp Leu Ala Lys Ala Glu Phe Tyr Ala Asn Lys Ile Ser Glu 
                725                 730                 735     


Ser Asp Tyr Leu Leu Lys Arg Lys Phe Leu Pro Pro Phe Ser Gly Phe 
            740                 745                 750         


Lys Glu Gln Ala Leu Glu Lys Val Lys Asn Ile Phe Val Ser His Ser 
        755                 760                 765             


Leu Lys Ile Lys Asn Lys Gly Thr Leu His Glu Leu Thr Pro Leu Lys 
    770                 775                 780                 


Ile Lys Glu Leu Lys Asn Thr Tyr Gly Asp Leu Asp Leu Ala Val Lys 
785                 790                 795                 800 


Leu Gly Lys Ile Arg Lys Tyr Asn Asp Lys Tyr Tyr Ala Asn Ala Lys 
                805                 810                 815     


Gly Ser Leu Val Arg Thr Asp Leu Phe Ala Asp Lys Glu Asn Lys Phe 
            820                 825                 830         


His Ala Val Ser Ile Tyr Lys Ala Asp Phe Ser Thr Lys Lys Leu Pro 
        835                 840                 845             


Asn Lys Thr Pro Ala Thr Thr Ser Asn Gly Glu Thr Lys Glu Gly Ile 
    850                 855                 860                 


Glu Met Asn Glu Asn Tyr Asn Phe Cys Met Ser Leu Tyr Lys Asn Thr 
865                 870                 875                 880 


Pro Ile Ser Val Lys Ile Lys Gly Met Lys Glu Pro Ile Ile Cys Tyr 
                885                 890                 895     


Tyr His Gly Phe Asn Thr Ser Gly Ser Lys Ile Thr Tyr Lys Lys His 
            900                 905                 910         


Asp Asn Asn Tyr His Asn Leu Ser Glu Asp Glu Met Val Val Phe Arg 
        915                 920                 925             


Lys Asn Asp Lys Glu Ser Ile Val Val Gly Lys Ile Leu Glu Ile Lys 
    930                 935                 940                 


Lys Tyr Ser Ile Ser Pro Ser Gly Glu Leu Ser Leu Ile Glu Asn Glu 
945                 950                 955                 960 


Glu Arg Lys Trp Phe 
                965 


<210> 113
<211> 987
<212> PRT
<213> Campylobacter coli


<220>
<223> Campylobacter coli 80352

<400> 113
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Asp His Ser Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn Tyr Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Lys Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Thr Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Glu Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Asn Glu Leu Arg 
            980                 985         


<210> 114
<211> 984
<212> PRT
<213> Campylobacter jejuni

<400> 114
Met Ala Lys Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Ile Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ile Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Gly Lys 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Leu Tyr Thr Lys Asp Asp Leu 
        275                 280                 285             


Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu Thr Tyr Lys 
    290                 295                 300                 


Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu Phe Lys Gly 
305                 310                 315                 320 


Glu Lys Gly Asn Tyr Phe Ile Glu Phe Lys Lys Tyr Lys Glu Phe Ile 
                325                 330                 335     


Lys Ala Leu Gly Glu His Ser Leu Ser Gln Asp Asp Leu Asn Glu Ile 
            340                 345                 350         


Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu Lys Lys Ala 
        355                 360                 365             


Leu Ala Lys Tyr Asp Leu Asn Glu Asn Gln Ile Asp Asn Leu Ser Lys 
    370                 375                 380                 


Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala Leu Lys Leu 
385                 390                 395                 400 


Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu Ala Cys Asn 
                405                 410                 415     


Glu Leu Thr Leu Lys Val Ala Ile Asn Glu Asp Lys Lys Asp Phe Leu 
            420                 425                 430         


Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr Asn Pro Val 
        435                 440                 445             


Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn Ala Leu Leu 
    450                 455                 460                 


Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu Ala Arg Glu 
465                 470                 475                 480 


Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys Glu Gln Asn 
                485                 490                 495     


Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys Glu Lys Leu 
            500                 505                 510         


Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg Leu Phe Lys 
        515                 520                 525             


Glu Gln Lys Glu Phe Cys Val Tyr Ser Gly Glu Lys Ile Lys Leu Ser 
    530                 535                 540                 


Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile Tyr Pro Tyr 
545                 550                 555                 560 


Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu Val Phe Thr 
                565                 570                 575     


Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu Ala Phe Gly 
            580                 585                 590         


Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala Lys Asn Leu 
        595                 600                 605             


Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr Lys Asp Lys 
    610                 615                 620                 


Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr Arg Tyr Ile 
625                 630                 635                 640 


Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp Phe Leu Pro 
                645                 650                 655     


Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln Lys Gly Ser 
            660                 665                 670         


Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser Ala Leu Arg 
        675                 680                 685             


His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His Leu His His 
    690                 695                 700                 


Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser Ile Val Lys 
705                 710                 715                 720 


Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Thr Ala Glu Leu 
                725                 730                 735     


Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys Arg Lys Phe 
            740                 745                 750         


Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp Lys Ile Asp 
        755                 760                 765             


Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser Gly Ala Leu 
    770                 775                 780                 


His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln Ser Tyr Gly 
785                 790                 795                 800 


Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys Ile Arg Lys 
                805                 810                 815     


Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg Val Asp Ile 
            820                 825                 830         


Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro Ile Tyr Thr 
        835                 840                 845             


Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val Ala Arg Ser 
    850                 855                 860                 


Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu Asn Tyr Glu 
865                 870                 875                 880 


Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile Gln Thr Lys 
                885                 890                 895     


Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe Thr Ser Ser 
            900                 905                 910         


Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe Glu Thr Leu 
        915                 920                 925             


Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu Lys Glu Val 
    930                 935                 940                 


Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe Glu Lys Tyr 
945                 950                 955                 960 


Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe Arg Gln Arg 
                965                 970                 975     


Glu Glu Phe Lys Asn Glu Leu Arg 
            980                 


<210> 115
<211> 987
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni 110-21

<400> 115
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asn Ile Lys Asn Ser Asp Asn Glu Glu Lys Ser Glu 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Val Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Gln Lys Gln Arg Glu Phe Gly Leu Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Thr Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Asp His Ser Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Val Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Asn Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Leu Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Lys Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Thr Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Ile Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Val Gln Gly Lys Asp Lys Lys Ser Gly Leu Ile Lys Asp Trp Ile Leu 
865                 870                 875                 880 


Met Asp Glu Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu 
                885                 890                 895     


Ile Leu Ile Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr 
            900                 905                 910         


Asn Ala Phe Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp 
        915                 920                 925             


Asn Lys Phe Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn 
    930                 935                 940                 


Ala Asn Glu Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu 
945                 950                 955                 960 


Lys Val Phe Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys 
                965                 970                 975     


Ala Glu Phe Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 985         


<210> 116
<211> 987
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni 129-258

<400> 116
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asn Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Val Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Gln Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Asp His Ser Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn Tyr Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Leu Val Tyr Phe Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Asn Glu Leu Arg 
            980                 985         


<210> 117
<211> 987
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni 1336

<400> 117
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Gly Lys 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Val Ser Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Gln Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Leu Leu Met Lys Lys Glu Arg Gln 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Thr Leu Leu Asn Glu Ala Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asn Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Gln Lys Tyr Lys 
                325                 330                 335     


Glu Phe Val Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Val Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Lys Thr Pro Phe Glu 
            580                 585                 590         


Thr Phe Gly Asn Asp Arg Val Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Thr Leu Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Ala Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Thr 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Leu Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Met Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Val Gln Gly Lys Asp Lys Lys Ser Gly Leu Ile Lys Asp Trp Ile Leu 
865                 870                 875                 880 


Met Asp Glu Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu 
                885                 890                 895     


Ile Leu Ile Gln Thr Lys Asp Met Gln Glu Pro Glu Leu Val Tyr Tyr 
            900                 905                 910         


Glu Arg Leu Asp Ser Ser Asn Ala Ser Leu Thr Val Ser Lys His Asp 
        915                 920                 925             


Asn Lys Phe Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn 
    930                 935                 940                 


Ala Asn Glu Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu 
945                 950                 955                 960 


Lys Val Phe Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys 
                965                 970                 975     


Ala Glu Phe Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 985         


<210> 118
<211> 984
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni 140-16

<400> 118
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Val Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Lys Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Ile Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 119
<211> 984
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni 1577

<400> 119
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Val Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Val Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Lys Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 120
<211> 987
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni 1854

<400> 120
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Thr Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ser Leu Gly Asp His Ser Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asn Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Asn Glu Leu Arg 
            980                 985         


<210> 121
<211> 984
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni 1997-10

<400> 121
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn Arg Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Asp His Ser Leu Asn Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn Tyr Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Val Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val Tyr Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 122
<211> 987
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni 2008-1025

<400> 122
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Ser Glu 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Val Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Gln Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Thr Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asn Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Tyr Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Val Gln Gly Lys Asp Lys Lys Ser Gly Leu Ile Lys Asp Trp Ile Leu 
865                 870                 875                 880 


Met Asp Glu Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu 
                885                 890                 895     


Ile Leu Ile Gln Thr Lys Asp Met Gln Glu Pro Glu Leu Val Tyr Phe 
            900                 905                 910         


Asn Ala Phe Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp 
        915                 920                 925             


Asn Lys Phe Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn 
    930                 935                 940                 


Ala Asn Glu Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu 
945                 950                 955                 960 


Lys Val Phe Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys 
                965                 970                 975     


Ala Glu Phe Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 985         


<210> 123
<211> 984
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni 2008-872

<400> 123
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Val Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Lys Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 124
<211> 987
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni 2008-979

<400> 124
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Val Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Asp His Ser Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn Tyr Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Glu Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Leu Val Tyr Phe Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Asn Glu Leu Arg 
            980                 985         


<210> 125
<211> 965
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni 2008-988

<400> 125
Met Lys Ile Ile Gly Phe Asn Leu Gly Ile Ala Asn Ile Gly Trp Ala 
1               5                   10                  15      


Leu Arg Glu Asn Asp Glu Ile Ile Asp Cys Gly Val Arg Val Phe Asp 
            20                  25                  30          


Ile Pro Glu Asn Pro Lys Asn Gly Asn Ser Leu Ala Leu Glu Arg Arg 
        35                  40                  45              


Glu Asn Lys Ala Arg Met Lys Ile Val Lys Arg Lys Lys Ala Arg Met 
    50                  55                  60                  


Leu Ala Thr Lys Thr Phe Leu Lys Lys Glu Leu Asn Val Asp Leu Ser 
65                  70                  75                  80  


Lys Leu Phe Leu Ile Gly Ser Thr Gln Ser Ile Tyr Glu Leu Arg Ala 
                85                  90                  95      


Lys Ala Leu Ser Ser Leu Ile Ser Lys Glu Glu Leu Ser Ala Ile Ile 
            100                 105                 110         


Leu His Ile Ala Lys His Arg Gly Tyr Asp Asp Ser Ala Leu Lys Asn 
        115                 120                 125             


Glu Asn Gly Thr Ile Ile Glu Ala Leu Asn Lys Asn Lys Glu Thr Met 
    130                 135                 140                 


Leu Lys Phe Lys Ser Val Gly Glu Tyr Phe Tyr Lys Asn Phe Val Gln 
145                 150                 155                 160 


Asn Lys Glu Val Lys Lys Ile Arg Asn Thr Thr Glu Asp Tyr Ser Asn 
                165                 170                 175     


Ser Val Pro Arg Ser Leu Leu Lys Gln Glu Leu Asp Leu Ile Leu Asp 
            180                 185                 190         


Lys Gln Lys Glu Leu Gly Leu Ile Lys Asn Ala Asp Phe Lys Glu Lys 
        195                 200                 205             


Leu Phe Glu Ile Ile Phe Phe Lys Arg Pro Leu Lys Asp Phe Ser Asn 
    210                 215                 220                 


Lys Ile Gly Asn Cys Ile Phe Phe Glu Asn Glu Lys Arg Ala Ala Lys 
225                 230                 235                 240 


Asn Thr Ile Ser Ala Cys Glu Phe Val Ala Leu Gly Lys Val Val Asn 
                245                 250                 255     


Leu Leu Lys Ser Ile Glu Lys Asp Ile Gly Ile Val Tyr Glu Lys Asp 
            260                 265                 270         


Ser Ile Asn Glu Ile Met Ser Ile Ile Leu Asp Lys Thr Ser Ile Ser 
        275                 280                 285             


Tyr Lys Lys Ile Arg Asp Ile Leu Asn Leu Pro Gln Glu Ile Asn Phe 
    290                 295                 300                 


Lys Gly Leu Asp Tyr Ser Lys Asn Asn Val Glu Asn Ser Lys Leu Val 
305                 310                 315                 320 


Asp Leu Lys Lys Leu Asn Glu Phe Lys Lys Ala Leu Gly Asp Gly Phe 
                325                 330                 335     


Ala Asn Leu Asp Lys Asp Ile Leu Asp Ser Ile Ala Thr Asp Ile Thr 
            340                 345                 350         


Leu Thr Lys Asp Thr Ala Thr Leu Lys Glu Lys Leu Lys Asn Tyr Asn 
        355                 360                 365             


Val Leu Asn Ala Glu Gln Ile Glu Lys Leu Ser Glu Leu Val Phe Asn 
    370                 375                 380                 


Asp His Ile Asn Leu Ser Leu Lys Ala Leu Lys Gln Ile Ile Pro Leu 
385                 390                 395                 400 


Met Tyr Glu Gly Lys Arg Tyr Asp Glu Ala Cys Glu Leu Cys Asn Phe 
                405                 410                 415     


Thr Ile Ala Lys Asn Gln Glu Lys Ser Glu Tyr Leu Pro Leu Phe Glu 
            420                 425                 430         


Lys Thr Arg Phe Ala Lys Asp Ile Ser Ser Pro Val Val Ile Arg Ala 
        435                 440                 445             


Ile Cys Glu Phe Arg Lys Leu Leu Asn Asp Ile Ile Arg Arg Tyr Gly 
    450                 455                 460                 


Ser Val His Lys Ile His Leu Glu Leu Thr Arg Asp Phe Gly Ile Ser 
465                 470                 475                 480 


Phe Ser Asp Arg Lys Lys Ile Ile Lys Glu Ile Glu Gln Asn Glu Gln 
                485                 490                 495     


Ser Arg Ile Lys Ala Leu Glu Thr Ile Lys Glu Leu Lys Leu Glu Glu 
            500                 505                 510         


Thr Ser Lys Asn Ile Gln Ile Val Arg Leu Phe Glu Asp Gln Lys Gly 
        515                 520                 525             


Ile Cys Pro Tyr Ser Gly Leu Lys Met Asp Leu Asn Arg Leu Asp Glu 
    530                 535                 540                 


Leu Val Ile Asp Tyr Ile Arg Pro Tyr Asn Arg Ser Leu Asp Asp Ser 
545                 550                 555                 560 


Tyr Ser Asn Lys Val Leu Thr Phe Lys Lys Leu Ser Asp Leu Lys Gln 
                565                 570                 575     


Gly Lys Thr Pro Phe Glu Ala Phe Gly Glu Asp Glu Lys Leu Trp Ala 
            580                 585                 590         


Glu Ile Asn Glu Arg Ile Lys Glu Tyr Asn Gly Lys Lys Arg Phe Lys 
        595                 600                 605             


Ile Phe Asp Lys Phe Phe Lys Asp Lys Lys Pro Phe Asp Phe Thr Glu 
    610                 615                 620                 


Gln Thr Leu Gln Asp Thr Arg Trp Leu Thr Lys Leu Val Ala Ser Tyr 
625                 630                 635                 640 


Leu Asn Glu Tyr Leu Ser Phe Leu Pro Ile Ser Glu Asp Glu Asn Thr 
                645                 650                 655     


Ala Leu Gly Tyr Gly Glu Lys Gly Ser Lys Gln His Val Ile Leu Ser 
            660                 665                 670         


Ser Gly Met Ile Thr Gln Met Leu Arg Asn Phe Trp Tyr Leu Gly Phe 
        675                 680                 685             


Lys Asn His Lys Asp Tyr Lys Asn Asn Ala Met Asp Ala Ile Ile Val 
    690                 695                 700                 


Ala Phe Thr Thr Asn Ser Ile Ile Phe Ala Phe Asn Asn Phe Lys Lys 
705                 710                 715                 720 


Glu Leu Asp Leu Ala Lys Ala Glu Phe Tyr Ala Asn Lys Ile Ser Glu 
                725                 730                 735     


Ser Asp Tyr Leu Leu Lys Arg Lys Phe Leu Pro Pro Phe Ser Gly Phe 
            740                 745                 750         


Lys Glu Gln Ala Leu Glu Lys Val Lys Asn Ile Phe Val Ser His Ser 
        755                 760                 765             


Leu Lys Ile Lys Asn Lys Gly Thr Leu His Asp Leu Thr Pro Leu Lys 
    770                 775                 780                 


Ile Lys Glu Leu Lys Asn Thr Tyr Gly Asp Leu Asp Leu Ala Val Lys 
785                 790                 795                 800 


Leu Gly Lys Ile Arg Lys Tyr Asn Asp Lys Tyr Tyr Ala Asn Ala Asn 
                805                 810                 815     


Gly Ser Leu Val Arg Ala Asp Leu Phe Val Asp Lys Lys Asn Lys Phe 
            820                 825                 830         


His Ala Val Ser Ile Tyr Lys Ala Asp Phe Ser Thr Lys Lys Leu Pro 
        835                 840                 845             


Asn Lys Thr Pro Ala Thr Thr Ser Asn Gly Glu Thr Lys Glu Gly Ile 
    850                 855                 860                 


Glu Met Asn Glu Asn Tyr Asn Phe Cys Met Ser Leu Tyr Lys Asn Thr 
865                 870                 875                 880 


Pro Ile Ser Val Lys Ile Lys Gly Met Lys Glu Pro Ile Ile Cys Tyr 
                885                 890                 895     


Tyr His Gly Phe Asn Thr Ser Gly Ser Lys Ile Thr Tyr Lys Lys His 
            900                 905                 910         


Asp Asn Asn Tyr His Asn Leu Ser Glu Asp Glu Met Val Val Phe Arg 
        915                 920                 925             


Lys Asn Asp Lys Glu Ser Ile Ala Val Gly Lys Ile Leu Glu Ile Lys 
    930                 935                 940                 


Lys Tyr Ser Ile Ser Pro Ser Gly Glu Leu Ser Leu Ile Glu Asn Glu 
945                 950                 955                 960 


Glu Arg Lys Trp Phe 
                965 


<210> 126
<211> 984
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni 2008-988

<400> 126
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Val Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Thr Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Lys Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 127
<211> 961
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni 260.94

<400> 127
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Gly Lys 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Val Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Thr Gln Ser Phe Leu Lys Tyr Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Gln Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Ser Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Gly Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Leu Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Lys Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Asn Val Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Glu Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Lys Gly Ser Lys 
            660                 665                 670         


Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser Ala Leu Arg His 
        675                 680                 685             


Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His Leu His His Ala 
    690                 695                 700                 


Ile Asp Ala Ala Ile Ile Ala Tyr Ala Asn Asn Ser Ile Val Lys Asp 
705                 710                 715                 720 


Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser Ala Glu Leu Tyr 
                725                 730                 735     


Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys Arg Lys Phe Phe 
            740                 745                 750         


Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp Lys Ile Asp Glu 
        755                 760                 765             


Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser Gly Ala Leu His 
    770                 775                 780                 


Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln Ser Tyr Gly Gly 
785                 790                 795                 800 


Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys Ile Arg Lys Val 
                805                 810                 815     


Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg Val Asp Ile Phe 
            820                 825                 830         


Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro Ile Tyr Thr Met 
        835                 840                 845             


Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val Ala Arg Ser Lys 
    850                 855                 860                 


Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu Asn Tyr Glu Phe 
865                 870                 875                 880 


Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile Gln Thr Lys Asp 
                885                 890                 895     


Met Gln Glu Pro Glu Leu Val Tyr Phe Asn Ala Phe Thr Ser Ser Thr 
            900                 905                 910         


Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe Glu Thr Leu Ser 
        915                 920                 925             


Lys Asn Leu Lys Val Phe Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu 
    930                 935                 940                 


Val Thr Lys Ala Glu Phe Arg Gln Arg Glu Asp Phe Lys Asn Glu Leu 
945                 950                 955                 960 


Arg 
    


<210> 128
<211> 985
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni 414

<400> 128
Met Ala Lys Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Val Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Thr Leu Ile Ser Pro Tyr Glu Leu Arg Phe Lys Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Leu Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asn Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Val Lys Glu Asn Glu Glu Lys Leu Ala Asn Tyr Lys 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Gln Lys Gln Arg Glu Phe Gly Phe Asn Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Val Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Glu Phe Val Ala Leu Thr Arg Ile Val 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Asn Lys Asn Asn Ser Tyr Ile Lys Asp Asp 
        275                 280                 285             


Leu Asn Ala Leu Leu Ser Glu Val Leu Lys Asn Gly Thr Leu Thr Tyr 
    290                 295                 300                 


Lys Gln Thr Lys Lys Ile Leu Gly Leu Ser Asp Asp Tyr Glu Phe Lys 
305                 310                 315                 320 


Gly Gln Lys Gly Asn Tyr Phe Ile Glu Phe Lys Lys Tyr Lys Glu Phe 
                325                 330                 335     


Ile Lys Ala Leu Cys Glu His Asn Leu Asn Gln Asp Asp Leu Asn Glu 
            340                 345                 350         


Ile Ala Lys Asp Ile Thr Leu Val Lys Asp Glu Thr Lys Leu Lys Lys 
        355                 360                 365             


Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Glu Asn Leu Ser 
    370                 375                 380                 


Lys Ile Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala Leu Lys 
385                 390                 395                 400 


Leu Ile Val Pro Leu Met Arg Glu Gly Lys Lys Tyr Asp Glu Val Cys 
                405                 410                 415     


Asn Glu Leu Asn Leu Lys Thr Ala Ile Asn Glu Asp Lys Lys Glu Phe 
            420                 425                 430         


Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Asn Asn Pro 
        435                 440                 445             


Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn Ser Leu 
    450                 455                 460                 


Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu Ala Arg 
465                 470                 475                 480 


Glu Val Gly Lys Asn His Arg Glu Arg Ser Lys Ile Glu Lys Glu Gln 
                485                 490                 495     


Asn Glu Asn Phe Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys Glu Lys 
            500                 505                 510         


Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg Leu Phe 
        515                 520                 525             


Lys Glu Gln Lys Glu Phe Cys Val Tyr Ser Gly Glu Lys Ile Lys Ile 
    530                 535                 540                 


Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile Tyr Pro 
545                 550                 555                 560 


Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu Val Phe 
                565                 570                 575     


Thr Lys Gln Asn Gln Glu Lys Leu Asn Lys Thr Pro Phe Glu Ala Phe 
            580                 585                 590         


Gly Lys Asp Asp Val Lys Trp Gln Lys Ile Glu Thr Leu Ala Lys Asn 
        595                 600                 605             


Leu Pro Ala Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr Lys Asp 
    610                 615                 620                 


Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr Arg Tyr 
625                 630                 635                 640 


Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Glu Phe Leu 
                645                 650                 655     


Pro Leu Ser Asp Asp Glu Asn Ile Lys Leu Asn Asp Thr Gln Lys Gly 
            660                 665                 670         


Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser Val Leu 
        675                 680                 685             


Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His Leu His 
    690                 695                 700                 


His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Ala Ser Val Val 
705                 710                 715                 720 


Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Asn Tyr Thr Ala Glu 
                725                 730                 735     


Leu Tyr Ala Lys Lys Ile Asn Glu Leu Asp Phe Lys Asn Lys Arg Lys 
            740                 745                 750         


Phe Phe Glu Pro Phe Ser Asn Phe Arg Gln Lys Val Leu Glu Lys Ile 
        755                 760                 765             


Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser Gly Ala 
    770                 775                 780                 


Leu His Glu Glu Thr Phe Tyr Lys Glu Glu Glu Phe Tyr Lys Glu Tyr 
785                 790                 795                 800 


Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys Ile Arg 
                805                 810                 815     


Lys Val Asn Gly Lys Ile Val Ser Asn Ala Asn Met Phe Arg Val Asp 
            820                 825                 830         


Ile Phe Lys Tyr Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro Ile Tyr 
        835                 840                 845             


Thr Met Asp Phe Ala Leu Gly Ile Leu Pro Asn Lys Ala Val Val Gly 
    850                 855                 860                 


Gly Lys Asp Lys Gln Gly Ile Ile Lys Asp Trp Leu Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Leu 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Leu Val Tyr Phe Lys Ser Phe 
            900                 905                 910         


Lys Ser Ser Thr Ala Gly Leu Val Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Asn Leu Asn Glu Asn Gln Lys Lys Leu Phe Lys Ser Ala Asn Glu 
    930                 935                 940                 


Lys Lys Val Val Ala Glu Gly Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Ile Thr Lys Ala Glu Ile 
                965                 970                 975     


Lys Glu Arg Glu Asn Phe Lys Lys Lys 
            980                 985 


<210> 129
<211> 984
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni 51037

<400> 129
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Val Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Thr 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Thr Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn Tyr Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 130
<211> 984
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni 51494

<400> 130
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Thr Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn Tyr Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Lys Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Thr Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Glu Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Leu Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 131
<211> 987
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni 53161

<400> 131
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Gly Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Ser Glu 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Val Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Gln Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Thr Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asn Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Tyr Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Val Gln Gly Lys Asp Lys Lys Ser Gly Leu Ile Lys Asp Trp Ile Leu 
865                 870                 875                 880 


Met Asp Glu Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu 
                885                 890                 895     


Ile Leu Ile Gln Thr Lys Asp Met Gln Glu Pro Glu Leu Val Tyr Phe 
            900                 905                 910         


Asn Ala Phe Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp 
        915                 920                 925             


Asn Lys Phe Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn 
    930                 935                 940                 


Ala Asn Glu Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu 
945                 950                 955                 960 


Lys Val Phe Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys 
                965                 970                 975     


Ala Glu Phe Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 985         


<210> 132
<211> 984
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni 60004

<400> 132
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Gly Lys 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Val Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Thr Gln Ser Phe Leu Lys Tyr Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Gln Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Ile Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Ile Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Ile Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 133
<211> 984
<212> PRT
<213> Campylobacter jejuni

<400> 133
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Ser Glu 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Val Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Thr Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Gln Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Ile Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Ile Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Ile Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Leu Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Lys Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Thr Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Glu Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Ala Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Val Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Leu Val Tyr Phe Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 134
<211> 984
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni 84-25

<400> 134
Met Val Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Val Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Lys Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 135
<211> 984
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni 87459

<400> 135
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Thr Phe Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Asp His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Lys Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 136
<211> 984
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni ATCC 33560

<400> 136
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Asp His Ser Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn Tyr Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asn Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Thr Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 137
<211> 987
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni CF93-6

<400> 137
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Val Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Val Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asn Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Gly Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Asn Glu Leu Arg 
            980                 985         


<210> 138
<211> 984
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni CG8486

<400> 138
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Asp His Ser Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn Tyr Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 139
<211> 984
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni HB93-13

<400> 139
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Val Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Leu Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Tyr Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Leu Val Tyr Phe Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 140
<211> 987
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni LMG 23210

<400> 140
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Asp His Ser Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Val Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn Tyr Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Leu Val Tyr Phe Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Asn Glu Leu Arg 
            980                 985         


<210> 141
<211> 984
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni LMG 23211

<400> 141
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Ser Glu 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Val Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Thr Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Gln Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Asp Glu His Ser Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Ile Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Ile Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Lys Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Gly Val Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Glu Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Ala Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Leu Val Tyr Phe Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Val Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 142
<211> 984
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni LMG 23263

<400> 142
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Val Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Thr Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Asp His Ser Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Phe Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Lys Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 143
<211> 984
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni LMG 23264

<400> 143
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Val Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Lys Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asn Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 144
<211> 987
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni LMG 23269

<400> 144
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Ser Glu 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Val Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Gln Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Thr Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asn Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Tyr Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe His Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Val Gln Gly Lys Asp Lys Lys Ser Gly Leu Ile Lys Asp Trp Ile Leu 
865                 870                 875                 880 


Met Asp Glu Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu 
                885                 890                 895     


Ile Leu Ile Gln Thr Lys Asp Met Gln Glu Pro Glu Leu Val Tyr Phe 
            900                 905                 910         


Asn Ala Phe Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp 
        915                 920                 925             


Asn Lys Phe Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn 
    930                 935                 940                 


Ala Asn Glu Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu 
945                 950                 955                 960 


Lys Val Phe Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys 
                965                 970                 975     


Ala Glu Phe Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 985         


<210> 145
<211> 987
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni LMG 23357

<400> 145
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Cys Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Gly Glu 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Val Ser Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Gln Lys Gln Arg Lys Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Thr Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asn Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Gln Lys Tyr Lys 
                325                 330                 335     


Glu Phe Val Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Val Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Lys Thr Pro Phe Glu 
            580                 585                 590         


Thr Phe Gly Asn Asp Arg Val Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Thr Leu Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Ala Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Thr 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Leu Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Ser Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Val Gln Gly Lys Asp Lys Lys Ser Gly Leu Ile Lys Asp Trp Ile Leu 
865                 870                 875                 880 


Met Asp Glu Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu 
                885                 890                 895     


Ile Leu Ile Gln Thr Lys Asp Met Gln Glu Pro Glu Leu Val Tyr Tyr 
            900                 905                 910         


Glu Arg Leu Asp Ser Ser Asn Ala Ser Leu Thr Val Ser Lys His Asp 
        915                 920                 925             


Asn Lys Phe Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn 
    930                 935                 940                 


Ala Asn Glu Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu 
945                 950                 955                 960 


Lys Val Phe Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys 
                965                 970                 975     


Ala Glu Phe Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 985         


<210> 146
<211> 984
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819

<400> 146
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Val Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Val Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asn Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210> 147
<211> 983
<212> PRT
<213> Campylobacter jejuni


<220>
<223> Campylobacter jejuni subsp. jejuni NW

<400> 147
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Val Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asn Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Phe Tyr Gln Ser 
785                 790                 795                 800 


Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys Ile 
                805                 810                 815     


Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg Val 
            820                 825                 830         


Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro Ile 
        835                 840                 845             


Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val Ala 
    850                 855                 860                 


Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu Asn 
865                 870                 875                 880 


Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile Gln 
                885                 890                 895     


Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe Thr 
            900                 905                 910         


Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe Glu 
        915                 920                 925             


Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu Lys 
    930                 935                 940                 


Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe Glu 
945                 950                 955                 960 


Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe Arg 
                965                 970                 975     


Gln Arg Glu Asp Phe Lys Lys 
            980             


<210> 148
<211> 987
<212> PRT
<213> Campylobacter jejuni

<400> 148
Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Ser Glu 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Val Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Gln Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Thr Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asn Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Tyr Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Pro Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Val Gln Gly Lys Asp Lys Lys Ser Gly Leu Ile Lys Asp Trp Ile Leu 
865                 870                 875                 880 


Met Asp Glu Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu 
                885                 890                 895     


Ile Leu Ile Gln Thr Lys Asp Met Gln Glu Pro Glu Leu Val Tyr Phe 
            900                 905                 910         


Asn Ala Phe Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp 
        915                 920                 925             


Asn Lys Phe Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn 
    930                 935                 940                 


Ala Asn Glu Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu 
945                 950                 955                 960 


Lys Val Phe Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys 
                965                 970                 975     


Ala Glu Phe Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 985         


<210> 149
<211> 1003
<212> PRT
<213> Campylobacter lari

<400> 149
Met Arg Ile Leu Gly Phe Asp Ile Gly Ile Asn Ser Ile Gly Trp Ala 
1               5                   10                  15      


Phe Val Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe Thr 
            20                  25                  30          


Lys Ala Glu Asn Pro Lys Asn Lys Glu Ser Leu Ala Leu Pro Arg Arg 
        35                  40                  45              


Asn Ala Arg Ser Ser Arg Arg Arg Leu Lys Arg Arg Lys Ala Arg Leu 
    50                  55                  60                  


Ile Ala Ile Lys Arg Ile Leu Ala Lys Glu Leu Lys Leu Asn Tyr Lys 
65                  70                  75                  80  


Asp Tyr Val Ala Ala Asp Gly Glu Leu Pro Lys Ala Tyr Glu Gly Ser 
                85                  90                  95      


Leu Ala Ser Val Tyr Glu Leu Arg Tyr Lys Ala Leu Thr Gln Asn Leu 
            100                 105                 110         


Glu Thr Lys Asp Leu Ala Arg Val Ile Leu His Ile Ala Lys His Arg 
        115                 120                 125             


Gly Tyr Met Asn Lys Asn Glu Lys Lys Ser Asn Asp Ala Lys Lys Gly 
    130                 135                 140                 


Lys Ile Leu Ser Ala Leu Lys Asn Asn Ala Leu Lys Leu Glu Asn Tyr 
145                 150                 155                 160 


Gln Ser Val Gly Glu Tyr Phe Tyr Lys Glu Phe Phe Gln Lys Tyr Lys 
                165                 170                 175     


Lys Asn Thr Lys Asn Phe Ile Lys Ile Arg Asn Thr Lys Asp Asn Tyr 
            180                 185                 190         


Asn Asn Cys Val Leu Ser Ser Asp Leu Glu Lys Glu Leu Lys Leu Ile 
        195                 200                 205             


Leu Glu Lys Gln Lys Glu Phe Gly Tyr Asn Tyr Ser Glu Asp Phe Ile 
    210                 215                 220                 


Asn Glu Ile Leu Lys Val Ala Phe Phe Gln Arg Pro Leu Lys Asp Phe 
225                 230                 235                 240 


Ser His Leu Val Gly Ala Cys Thr Phe Phe Glu Glu Glu Lys Arg Ala 
                245                 250                 255     


Cys Lys Asn Ser Tyr Ser Ala Trp Glu Phe Val Ala Leu Thr Lys Ile 
            260                 265                 270         


Ile Asn Glu Ile Lys Ser Leu Glu Lys Ile Ser Gly Glu Ile Val Pro 
        275                 280                 285             


Thr Gln Thr Ile Asn Glu Val Leu Asn Leu Ile Leu Asp Lys Gly Ser 
    290                 295                 300                 


Ile Thr Tyr Lys Lys Phe Arg Ser Cys Ile Asn Leu His Glu Ser Ile 
305                 310                 315                 320 


Ser Phe Lys Ser Leu Lys Tyr Asp Lys Glu Asn Ala Glu Asn Ala Lys 
                325                 330                 335     


Leu Ile Asp Phe Arg Lys Leu Val Glu Phe Lys Lys Ala Leu Gly Val 
            340                 345                 350         


His Ser Leu Ser Arg Gln Glu Leu Asp Gln Ile Ser Thr His Ile Thr 
        355                 360                 365             


Leu Ile Lys Asp Asn Val Lys Leu Lys Thr Val Leu Glu Lys Tyr Asn 
    370                 375                 380                 


Leu Ser Asn Glu Gln Ile Asn Asn Leu Leu Glu Ile Glu Phe Asn Asp 
385                 390                 395                 400 


Tyr Ile Asn Leu Ser Phe Lys Ala Leu Gly Met Ile Leu Pro Leu Met 
                405                 410                 415     


Arg Glu Gly Lys Arg Tyr Asp Glu Ala Cys Glu Ile Ala Asn Leu Lys 
            420                 425                 430         


Pro Lys Thr Val Asp Glu Lys Lys Asp Phe Leu Pro Ala Phe Cys Asp 
        435                 440                 445             


Ser Ile Phe Ala His Glu Leu Ser Asn Pro Val Val Asn Arg Ala Ile 
    450                 455                 460                 


Ser Glu Tyr Arg Lys Val Leu Asn Ala Leu Leu Lys Lys Tyr Gly Lys 
465                 470                 475                 480 


Val His Lys Ile His Leu Glu Leu Ala Arg Asp Val Gly Leu Ser Lys 
                485                 490                 495     


Lys Ala Arg Glu Lys Ile Glu Lys Glu Gln Lys Glu Asn Gln Ala Val 
            500                 505                 510         


Asn Ala Trp Ala Leu Lys Glu Cys Glu Asn Ile Gly Leu Lys Ala Ser 
        515                 520                 525             


Ala Lys Asn Ile Leu Lys Leu Lys Leu Trp Lys Glu Gln Lys Glu Ile 
    530                 535                 540                 


Cys Ile Tyr Ser Gly Asn Lys Ile Ser Ile Glu His Leu Lys Asp Glu 
545                 550                 555                 560 


Lys Ala Leu Glu Val Asp His Ile Tyr Pro Tyr Ser Arg Ser Phe Asp 
                565                 570                 575     


Asp Ser Phe Ile Asn Lys Val Leu Val Phe Thr Lys Glu Asn Gln Glu 
            580                 585                 590         


Lys Leu Asn Lys Thr Pro Phe Glu Ala Phe Gly Lys Asn Ile Glu Lys 
        595                 600                 605             


Trp Ser Lys Ile Gln Thr Leu Ala Gln Asn Leu Pro Tyr Lys Lys Lys 
    610                 615                 620                 


Asn Lys Ile Leu Asp Glu Asn Phe Lys Asp Lys Gln Gln Glu Asp Phe 
625                 630                 635                 640 


Ile Ser Arg Asn Leu Asn Asp Thr Arg Tyr Ile Ala Thr Leu Ile Ala 
                645                 650                 655     


Lys Tyr Thr Lys Glu Tyr Leu Asn Phe Leu Leu Leu Ser Glu Asn Glu 
            660                 665                 670         


Asn Ala Asn Leu Lys Ser Gly Glu Lys Gly Ser Lys Ile His Val Gln 
        675                 680                 685             


Thr Ile Ser Gly Met Leu Thr Ser Val Leu Arg His Thr Trp Gly Phe 
    690                 695                 700                 


Asp Lys Lys Asp Arg Asn Asn His Leu His His Ala Leu Asp Ala Ile 
705                 710                 715                 720 


Ile Val Ala Tyr Ser Thr Asn Ser Ile Ile Lys Ala Phe Ser Asp Phe 
                725                 730                 735     


Arg Lys Asn Gln Glu Leu Leu Lys Ala Arg Phe Tyr Ala Lys Glu Leu 
            740                 745                 750         


Thr Ser Asp Asn Tyr Lys His Gln Val Lys Phe Phe Glu Pro Phe Lys 
        755                 760                 765             


Ser Phe Arg Glu Lys Ile Leu Ser Lys Ile Asp Glu Ile Phe Val Ser 
    770                 775                 780                 


Lys Pro Pro Arg Lys Arg Ala Arg Arg Ala Leu His Lys Asp Thr Phe 
785                 790                 795                 800 


His Ser Glu Asn Lys Ile Ile Asp Lys Cys Ser Tyr Asn Ser Lys Glu 
                805                 810                 815     


Gly Leu Gln Ile Ala Leu Ser Cys Gly Arg Val Arg Lys Ile Gly Thr 
            820                 825                 830         


Lys Tyr Val Glu Asn Asp Thr Ile Val Arg Val Asp Ile Phe Lys Lys 
        835                 840                 845             


Gln Asn Lys Phe Tyr Ala Ile Pro Ile Tyr Ala Met Asp Phe Ala Leu 
    850                 855                 860                 


Gly Ile Leu Pro Asn Lys Ile Val Ile Thr Gly Lys Asp Lys Asn Asn 
865                 870                 875                 880 


Asn Pro Lys Gln Trp Gln Thr Ile Asp Glu Ser Tyr Glu Phe Cys Phe 
                885                 890                 895     


Ser Leu Tyr Lys Asn Asp Leu Ile Leu Leu Gln Lys Lys Asn Met Gln 
            900                 905                 910         


Glu Pro Glu Phe Ala Tyr Tyr Asn Asp Phe Ser Ile Ser Thr Ser Ser 
        915                 920                 925             


Ile Cys Val Glu Lys His Asp Asn Lys Phe Glu Asn Leu Thr Ser Asn 
    930                 935                 940                 


Gln Lys Leu Leu Phe Ser Asn Ala Lys Glu Gly Ser Val Lys Val Glu 
945                 950                 955                 960 


Ser Leu Gly Ile Gln Asn Leu Lys Val Phe Glu Lys Tyr Ile Ile Thr 
                965                 970                 975     


Pro Leu Gly Asp Lys Ile Lys Ala Asp Phe Gln Pro Arg Glu Asn Ile 
            980                 985                 990         


Ser Leu Lys Thr Ser Lys Lys Tyr  Gly Leu Arg 
        995                 1000             


<210> 150
<211> 1430
<212> PRT
<213> Capnocytophaga canimorsus

<400> 150
Met Lys His Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Val Val Lys Glu Ala Gln Asn Asp Asn Glu Gln Ser Glu Ile Val 
            20                  25                  30          


Asp Val Gly Val Arg Val Asn Pro Leu Thr Thr Asp Glu Lys Thr Asn 
        35                  40                  45              


Phe Glu Lys Gly Lys Pro Ile Ser Thr Asn Ala Asp Arg Thr Leu Lys 
    50                  55                  60                  


Arg Ser Ala Arg Arg Asn Leu Gln Arg Tyr Lys Leu Arg Arg Lys Glu 
65                  70                  75                  80  


Leu Ile Glu Leu Leu Lys Glu His Gln Leu Ile Ser Thr Asp Thr Ile 
                85                  90                  95      


Leu Thr Glu Asn Gly Lys Gly Thr Thr Phe Gln Thr Leu Glu Leu Arg 
            100                 105                 110         


Ala Lys Ser Ala Lys Glu Lys Ile Ser Leu Glu Glu Leu Ala Arg Val 
        115                 120                 125             


Phe Leu Thr Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala 
    130                 135                 140                 


Lys Asn Glu Asp Glu Gly Gln Leu Ile Asp Gly Met Glu Ile Ala Lys 
145                 150                 155                 160 


Arg Leu Tyr Glu Glu Asn Leu Thr Thr Gly Gln Leu Ser Leu Gln Leu 
                165                 170                 175     


Leu Lys Glu Gly Lys Lys Ser Leu Pro Asp Tyr Tyr Arg Ser Asp Leu 
            180                 185                 190         


Gln Phe Glu Leu Asp Lys Val Trp Asn Phe Gln Lys Gln Phe His Ser 
        195                 200                 205             


His Ile Leu Thr Asp Glu Phe Tyr Ala Gln Leu Lys Gly Lys Gly Gln 
    210                 215                 220                 


Arg Ala Thr Ser Ala Leu Phe Leu Ala Lys Tyr Gln Ile Tyr Thr Ala 
225                 230                 235                 240 


Glu Asn Lys Gly Ser Arg Glu Asp Lys Lys Leu Gln Ala Tyr Gln Trp 
                245                 250                 255     


Arg Val Asp Ala Leu Ser Lys Glu Leu Thr Arg Glu Gln Leu Ala Phe 
            260                 265                 270         


Val Ile Thr Glu Ile Asn Asn Asn Leu Asn Asn Ser Ser Gly Tyr Leu 
        275                 280                 285             


Gly Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Asn Glu Thr 
    290                 295                 300                 


Val Gly Glu Tyr Leu Trp Lys Gln Ile Ala Ala Asn Pro His Thr Ser 
305                 310                 315                 320 


Leu Lys Asn Gln Val Phe Tyr Arg Gln Asp Tyr Leu Asp Glu Phe Glu 
                325                 330                 335     


Gln Ile Trp Lys Thr Gln Ser Ala Phe Tyr Pro Glu Ile Leu Thr Asp 
            340                 345                 350         


Glu Leu Lys Lys Glu Leu Arg Asp Val Val Ile Phe Tyr Gln Arg Lys 
        355                 360                 365             


Leu Lys Ser Gln Lys Ser Leu Val Ser Phe Cys Glu Phe Glu Asn Lys 
    370                 375                 380                 


Glu Ile Glu Ile Lys Lys Glu Asp Gly Thr Ser Thr Lys Lys Val Ile 
385                 390                 395                 400 


Gly Leu Lys Val Ala Pro Lys Ser Ser Pro Leu Phe Gln Glu Phe Lys 
                405                 410                 415     


Ile Trp Gln Asn Leu Asn Asn Val Leu Ile Arg Lys Lys Gly Ser Lys 
            420                 425                 430         


Thr Lys Lys Val Asp Lys Asn Gln Gln Ala Val Leu Phe Glu Glu Glu 
        435                 440                 445             


Lys Thr Ile Phe Glu Leu Asp Leu Glu Ala Lys Gln Ala Leu Phe Asn 
    450                 455                 460                 


Glu Leu Asn Leu Lys Gly Asn Leu Lys Ala Tyr Tyr Cys Leu Glu Ile 
465                 470                 475                 480 


Leu Gly Tyr Ser Pro Lys Glu Trp Glu Met Asn Tyr Ser Val Leu Glu 
                485                 490                 495     


Gly Asn Arg Thr Asn Lys Ala Leu Tyr Glu Ala Tyr Leu Lys Ile Thr 
            500                 505                 510         


Asp Leu Glu Gly Tyr Asp Ala Lys Asn His Leu Lys Val Lys Leu Asn 
        515                 520                 525             


Lys Asp Glu Val Glu Leu Asp Asp Leu Lys Val Pro Ala Ser Glu Ile 
    530                 535                 540                 


Lys Asp Met Val Gln Ala Ile Phe Lys Glu Ala Gly Ile Asn Thr Asp 
545                 550                 555                 560 


Ile Leu His Phe Asn Ala Glu Leu Asp Gly Lys Asp Phe Glu Asn Gln 
                565                 570                 575     


Ala Ser Tyr Gln Leu Trp His Leu Leu Tyr Ser Tyr Glu Gly Asp Asp 
            580                 585                 590         


Ser Lys Ser Gly Asn Glu Leu Leu Tyr Lys Leu Leu Glu Thr Lys Phe 
        595                 600                 605             


Gly Phe Lys Lys Glu Tyr Ala Gln Ile Leu Ala Asn Val Ser Leu Ser 
    610                 615                 620                 


Asp Asp Tyr Gly Ser Leu Ser Thr Lys Ala Met Arg Lys Ile His Pro 
625                 630                 635                 640 


Tyr Ile Lys Glu Asn Lys Phe Ser Thr Ala Cys Glu Leu Ala Gly Tyr 
                645                 650                 655     


Arg His Ser Lys His Ser Leu Thr Lys Glu Glu Asn Asp Asn Arg Val 
            660                 665                 670         


Leu Lys Asp Ser Leu Glu Val Leu Lys Lys Asn Ser Leu Arg Gln Pro 
        675                 680                 685             


Val Val Glu Lys Ile Leu Asn Gln Met Ile Asn Leu Val Asn Ala Leu 
    690                 695                 700                 


Leu Lys Lys Tyr Arg Thr Glu Asn Pro Asn Phe Lys Phe Asp Glu Ile 
705                 710                 715                 720 


Arg Ile Glu Leu Ala Arg Glu Leu Lys Lys Asn Ala Glu Glu Arg Ala 
                725                 730                 735     


Asn Met Thr Val Asn Ile Asn Lys Ala Lys Thr Glu His Glu Lys Ile 
            740                 745                 750         


Ile Lys Ile Leu Lys Asn Glu Phe Gly Leu Pro Asn Pro Thr Arg Asn 
        755                 760                 765             


Asp Ile Ile Arg Tyr Arg Leu Tyr Glu Glu Leu Lys Ala Asn Gly Tyr 
    770                 775                 780                 


Lys Asp Leu Tyr Thr Asn Glu Tyr Ile Glu Lys Gln Asp Leu Phe Thr 
785                 790                 795                 800 


Lys Asn Ile Asp Ile Glu His Ile Ile Pro Lys Ser Arg Val Phe Asp 
                805                 810                 815     


Asp Ser Phe Ser Asn Lys Thr Leu Ser Phe Arg Lys Thr Asn Leu Asp 
            820                 825                 830         


Lys Gly Glu Arg Thr Ala Phe Asp Tyr Ile Glu Ser Lys Phe Gly Ala 
        835                 840                 845             


Asp Lys Leu Glu Glu Tyr Val Ala Arg Val Glu Asp Leu Tyr Lys Asn 
    850                 855                 860                 


Asn Ile Ile Ser Lys Ala Lys Tyr Gln Lys Leu Leu Lys Lys Glu Ser 
865                 870                 875                 880 


Glu Ile Gly Asp Gly Phe Val Glu Arg Asp Leu Arg Glu Thr Gln Tyr 
                885                 890                 895     


Ile Ala Lys Lys Ala Lys Glu Ile Leu Leu Gln Ile Thr Pro Asn Val 
            900                 905                 910         


Leu Ser Thr Ser Gly Gly Ile Thr Asp Arg Leu Arg Glu Asp Trp Asp 
        915                 920                 925             


Leu Ile Asn Val Met Lys Glu Leu Asn Leu Pro Lys Tyr Arg Ala Leu 
    930                 935                 940                 


Gly Leu Thr Gln Met Glu Asp Arg Lys Tyr Gly Gln Gln Val Glu Val 
945                 950                 955                 960 


Ile Ile Asp Trp Thr Lys Arg Asn Asp His Arg His His Ala Met Asp 
                965                 970                 975     


Ala Leu Thr Val Ala Phe Thr Lys His Asn His Ile Gln Tyr Leu Asn 
            980                 985                 990         


Tyr Leu Asn Ala Arg Lys Asn Glu  Lys His Arg Glu His  Ser Asn Ile 
        995                 1000                 1005             


Met Gly  Ile Gln Gln Leu Glu  Thr Ile Lys Val Thr  Asp Lys Asn 
    1010                 1015                 1020             


Gly Asn  Glu Lys Arg Val Phe  Lys Ala Pro Met Pro  Asn Phe Arg 
    1025                 1030                 1035             


Gln Val  Thr Lys Ala Phe Leu  Glu Asn Val Leu Ile  Ser His Lys 
    1040                 1045                 1050             


Ala Lys  Asn Lys Val Val Thr  Lys Asn Lys Asn Lys  Val Ala Gly 
    1055                 1060                 1065             


Ser Asn  Lys Val Gln Glu Val  Leu Thr Pro Arg Gly  Gln Leu His 
    1070                 1075                 1080             


Lys Glu  Thr Val Tyr Gly Lys  Tyr Gln Tyr Tyr Val  Gln Lys Glu 
    1085                 1090                 1095             


Glu Lys  Ile Gly Gly Lys Phe  Asp Leu Glu Thr Ile  Lys Lys Val 
    1100                 1105                 1110             


Ala Asn  Pro Leu Tyr Gln Ser  Leu Leu Lys Lys Arg  Leu Glu Glu 
    1115                 1120                 1125             


Asn Gly  Gly Asp Pro Lys Lys  Ala Phe Thr Gly Lys  Asn Ser Leu 
    1130                 1135                 1140             


Ala Lys  Asn Pro Ile Tyr Leu  Asp Asp Ala Gln Thr  Glu Gln Leu 
    1145                 1150                 1155             


Pro Glu  Lys Val Lys Leu Val  Trp Leu Glu Asn Ser  Phe Ser Ile 
    1160                 1165                 1170             


Arg Lys  Asp Ile Thr Pro Glu  Asn Phe Lys Asp Glu  Lys Leu Ile 
    1175                 1180                 1185             


Asp Lys  Ile Leu Asp Glu Gly  Val Lys Arg Ile Leu  Lys Glu Arg 
    1190                 1195                 1200             


Leu Gln  Ser Phe Gly Asn Asp  Ala Lys Lys Ala Phe  Ser Asp Leu 
    1205                 1210                 1215             


Asp Lys  Asn Pro Ile Trp Leu  Asn Lys Glu Lys Gly  Ile Ala Ile 
    1220                 1225                 1230             


Lys Arg  Val Ala Ile Ser Gly  Val Ala Asn Ala Glu  Pro Leu His 
    1235                 1240                 1245             


Thr Lys  Lys Asp His Leu Gly  Lys Glu Ile Leu Asp  Lys Glu Gly 
    1250                 1255                 1260             


Lys Ser  Ile Pro Val Asp Phe  Ile Ser Thr Gly Asn  Asn His His 
    1265                 1270                 1275             


Val Ala  Val Tyr Arg Asp Glu  Lys Gly Asn Leu Gln  Glu Lys Val 
    1280                 1285                 1290             


Val Ser  Val Phe Glu Ala Val  Val Arg Ala Asn Gln  Gly Leu Pro 
    1295                 1300                 1305             


Ile Ile  Asp Lys Thr Tyr Asn  Gln His Leu Gly Trp  Glu Phe Leu 
    1310                 1315                 1320             


Phe Thr  Met Lys Gln Asn Glu  Met Phe Val Phe Ser  Asn Glu Ser 
    1325                 1330                 1335             


Thr Gly  Phe Asn Pro Asn Asp  Ile Asp Leu Leu Asp  Pro Lys Asn 
    1340                 1345                 1350             


Lys Lys  Ile Ile Ser Pro Asn  Leu Phe Arg Val Gln  Lys Phe Ser 
    1355                 1360                 1365             


Lys Leu  Gln Tyr Gly Asn Ser  Phe Val Arg Glu Phe  Val Phe Arg 
    1370                 1375                 1380             


His His  Leu Glu Thr Thr Val  Glu Asp Arg Lys Glu  Leu Gln Gly 
    1385                 1390                 1395             


Ile Thr  Tyr Lys Gln Met Lys  Asn Ser Ala Phe Phe  Asn Asp Ile 
    1400                 1405                 1410             


Ile Lys  Val Arg Ile Asn His  Leu Gly Gly Ile Val  Ser Val Gly 
    1415                 1420                 1425             


Glu Tyr  
    1430 


<210> 151
<211> 1436
<212> PRT
<213> Capnocytophaga gingivalis


<220>
<223> Capnocytophaga gingivalis ATCC 33624

<400> 151
Met Lys Tyr Ile Lys Tyr Ile Leu Gly Leu Asp Ile Gly Ser Asn Ser 
1               5                   10                  15      


Ile Gly Trp Ala Leu Ile Gln Leu Asp Leu Leu Gln Lys Thr Lys Arg 
            20                  25                  30          


Ile Ile Ala Ala Gly Ser Arg Ile Ile Pro Met Asp Gln Lys Val Leu 
        35                  40                  45              


Ser Asp Phe Gly Lys Gly Ile Thr Ile Ser Pro Thr Ala Gln Arg Thr 
    50                  55                  60                  


Ser Tyr Arg Asn Ala Arg His Cys Arg Glu Arg His Leu Leu Arg Arg 
65                  70                  75                  80  


Glu Arg Leu His Arg Val Leu His Ile Leu Gly Phe Leu Pro Thr His 
                85                  90                  95      


Tyr Asp Lys Gln Ile Asp Phe Ser Lys Arg Tyr Gly Lys Phe Val Asp 
            100                 105                 110         


Asn Thr Glu Pro Lys Ile Ala Tyr Asn Glu Gly Lys Phe Leu Phe Met 
        115                 120                 125             


Asp Ser Phe Gln Glu Met Leu Ser Asp Phe Lys Ser His Gln Pro Asp 
    130                 135                 140                 


Leu Phe Tyr Thr Lys Lys Asn Gly Glu Glu Ser Lys Ile Pro Tyr Asp 
145                 150                 155                 160 


Trp Thr Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Ser Gln Lys Ile Ser 
                165                 170                 175     


Lys Glu Glu Leu Ala Trp Ile Ile Leu Asn Phe Asn Gln Lys Arg Gly 
            180                 185                 190         


Tyr Tyr Gln Leu Arg Glu Glu Glu Gly Asn Lys Glu Asn Asp Phe Glu 
        195                 200                 205             


Ile Ile Ser Ser Lys Ile Ile Ser Val Ile Lys Lys Asp Lys Asp Lys 
    210                 215                 220                 


Lys Tyr Asn Lys Tyr Trp Tyr Asp Ile Ile Leu Glu Asn Gly Leu Val 
225                 230                 235                 240 


Tyr Gln Ala Ala Phe Tyr Asn Asp Phe Val Tyr Asn Trp Ile Asn Gln 
                245                 250                 255     


Asp Arg Glu Phe Ile Ile Glu Arg Thr Ser Leu Lys Asn Gly Ala Glu 
            260                 265                 270         


Lys Val Lys Leu Ser Tyr Leu Pro Thr Phe Asp Glu Ile Asp Lys Met 
        275                 280                 285             


Asp Lys Lys Glu Gln Asp Lys Tyr Tyr Lys Lys Ile Lys Ile Lys Thr 
    290                 295                 300                 


Glu Asn Ser Ile Gly Asn Lys Thr Val Gly Cys Tyr Ile Tyr Asp His 
305                 310                 315                 320 


Ile Leu Gln Asn Pro Asn Glu Lys Ile Lys Gly Lys Leu Val Arg Thr 
                325                 330                 335     


Ile Glu Arg Lys Tyr Tyr Lys Glu Glu Leu Lys Ala Ile Leu Glu Lys 
            340                 345                 350         


Gln Ile Ala Leu Gln Pro Glu Leu Phe Thr Asp Gln Leu Leu Ala Asp 
        355                 360                 365             


Cys Ile Arg Glu Leu Tyr Ser Lys Asn Glu Ala Gln Gln Arg Asn Leu 
    370                 375                 380                 


Ala Ala Arg Asp Phe Val His Leu Leu Val Glu Asp Ile Ile Phe Tyr 
385                 390                 395                 400 


Gln Arg Pro Leu Arg Arg Gln Lys Ser Thr Leu Ala Asn Cys Ser Leu 
                405                 410                 415     


Glu Ser Arg Ser Tyr Ile Asp Lys Asp Ser His Thr Arg Lys Glu Ala 
            420                 425                 430         


Pro Leu Lys Val Cys Pro Lys Ser Asn Pro Tyr Tyr Gln Glu Phe Arg 
        435                 440                 445             


Val Leu Gln Trp Leu Gln Asn Leu Lys Ile Tyr Glu Ile Asp Ser Asp 
    450                 455                 460                 


Gln Glu Val Thr His Gln Phe Ile Lys Thr Leu Glu Asp Lys Gln Gln 
465                 470                 475                 480 


Leu Phe Glu Phe Leu Met Ala Gln Lys Glu Ile Asp Cys Glu Glu Leu 
                485                 490                 495     


Leu Lys Tyr Phe Leu Asn Gln Thr Tyr Pro Asn Ala Lys Glu Lys Ala 
            500                 505                 510         


Leu Lys Ser Glu Leu Lys Lys Trp Lys Asp Thr Tyr Arg Trp Asn Tyr 
        515                 520                 525             


Val Tyr Asp Ile Gly Glu Lys Ser Ser Lys Lys Tyr Pro Met Asn Glu 
    530                 535                 540                 


Thr Arg Tyr Glu Leu Lys Arg His Leu Glu Lys Val Ala Asn Leu Pro 
545                 550                 555                 560 


Asp Asp Phe Leu Ser Ser Glu Val Glu Tyr Leu Leu Trp His Leu Ile 
                565                 570                 575     


Tyr Ser Val Lys Asp Lys Val Ala Tyr Glu Lys Gly Leu Lys Lys Phe 
            580                 585                 590         


Ala Gln Lys His His Leu Asp Lys Asp Ser Phe Val Glu Ser Phe Lys 
        595                 600                 605             


Lys Phe Asn Pro Tyr Pro Ser Glu Tyr Gly Ser Phe Ser Glu Lys Ala 
    610                 615                 620                 


Ile Arg Lys Leu Leu Pro Leu Met Arg Phe Gly Ala His Trp Asp Phe 
625                 630                 635                 640 


Asn His Ile Asp Lys Asn Thr Gln Lys Arg Ile Glu Asp Leu Ile Thr 
                645                 650                 655     


Gly Val Glu Asn Glu Glu Ile Arg Thr Ile Leu Arg Glu Lys Ala Glu 
            660                 665                 670         


Lys Tyr Gln Leu Glu Lys Glu Thr Asp Phe Gln Asp Leu Pro Leu Trp 
        675                 680                 685             


Leu Ala Gln Tyr Ile Val Tyr Asn Arg His Ala Glu Ala Ser Ser Leu 
    690                 695                 700                 


Glu Lys Trp Thr Ser Val Asn Asp Leu Glu Thr Tyr Leu Asn Glu Phe 
705                 710                 715                 720 


Lys Gln His Ser Leu Arg Asn Pro Ile Val Glu Gln Val Val Met Glu 
                725                 730                 735     


Thr Leu Arg Val Val Arg Asp Ile Trp Gln Gln Tyr Gly Gln Gly Gln 
            740                 745                 750         


Ala Ser Phe Phe Asn Glu Ile His Ile Glu Leu Gly Arg Glu Leu Lys 
        755                 760                 765             


Lys Thr Ala Lys Glu Arg Glu Lys Leu Ser Lys Gln Asn Gln Lys Asn 
    770                 775                 780                 


Glu Asp Ile Asn Leu Ser Ile Lys Glu Lys Leu Lys Glu Leu Glu Lys 
785                 790                 795                 800 


Tyr Asn Thr Arg Ala Tyr Ser Ile Thr His Gln Glu Lys Tyr Lys Leu 
                805                 810                 815     


Trp Leu Glu Gln Lys His Ile Ser Pro Tyr Thr Gly Gln Ile Ile Ser 
            820                 825                 830         


Pro Glu Asn Leu Phe Thr Asp Asn Tyr Glu Ile Glu His Ile Ile Pro 
        835                 840                 845             


Gln Ser Arg Phe Phe Asp Asp Ser Leu Ser Asn Lys Val Val Cys Glu 
    850                 855                 860                 


Ser Ile Val Asn Lys Ala Pro Tyr Lys Asp Arg Gln Leu Gly Leu Glu 
865                 870                 875                 880 


Phe Ile Lys Asn Gln Gly Gly Arg Ile Val Lys Glu Leu Ser Lys Glu 
                885                 890                 895     


Asn Lys Thr Ile Lys Ile Phe Thr Glu Glu Gln Tyr Arg Thr Phe Ile 
            900                 905                 910         


Lys Glu His Tyr Ser Asn Asn Pro Glu Lys Thr Lys Lys Leu Leu Leu 
        915                 920                 925             


Glu Glu Ile Pro Glu Lys Met Val Ala Arg Gln Met Asn Asp Thr Cys 
    930                 935                 940                 


Tyr Ile Ser Lys Phe Ile Ser Glu Ile Leu Ser Lys Ile Val Arg Ser 
945                 950                 955                 960 


Asp Glu Gln Asp Glu Gly Val His Ser Lys Asn Val Ile Leu Cys Thr 
                965                 970                 975     


Gly Lys Ile Thr Ser Ile Leu Arg Gln Asp Trp Gly Leu Asn Asp Ile 
            980                 985                 990         


Trp Asp Asn Leu Ile Leu Pro Arg  Phe Glu Arg Met Asn  Asn Leu Leu 
        995                 1000                 1005             


Gln Lys  Glu Lys Phe Thr Ile  Tyr Ser Ile Glu Lys  Gln Lys Lys 
    1010                 1015                 1020             


Ile Pro  Val Val Pro Ile Asn  Asp Gln Phe Lys Ser  Phe Gln Lys 
    1025                 1030                 1035             


Lys Arg  Ile Asp His Arg His  His Ala Met Asp Ala  Ile Ile Ile 
    1040                 1045                 1050             


Ala Cys  Thr Thr Arg Glu His  Ile Asn Tyr Ile Asn  Asn Gln His 
    1055                 1060                 1065             


Ala Leu  Glu Lys Glu Lys Asp  Lys Lys Glu Lys Gln  Glu Glu Arg 
    1070                 1075                 1080             


Asp Lys  Leu Arg Glu Lys Leu  Cys Ile Lys Lys Tyr  Asn Asn Arg 
    1085                 1090                 1095             


Ser Glu  Gly Asn Tyr Ser Trp  Ile Phe Lys Lys Pro  Trp Asp Thr 
    1100                 1105                 1110             


Phe Thr  Gln Glu Val Arg Val  Ala Leu Glu Asp Ile  Val Val Ser 
    1115                 1120                 1125             


Phe Lys  Gln Asn Leu Arg Val  Ile Asn Lys Ala Thr  Asn Tyr Tyr 
    1130                 1135                 1140             


Glu Arg  Trp Val Glu Glu Asn  Gly Lys Tyr Ile Lys  Lys Met Val 
    1145                 1150                 1155             


Lys Gln  Glu Gly Thr Asn Trp  Ala Ile Arg Lys Pro  Leu His Glu 
    1160                 1165                 1170             


Glu Thr  Ile Ser Gly Lys Ile  Tyr Leu Asp Arg Glu  Lys Ile Thr 
    1175                 1180                 1185             


Lys Asn  Asp Ile Leu Thr Ala  Thr Arg Lys Thr Val  Asp Ser Ser 
    1190                 1195                 1200             


Phe Asp  Asp Lys Arg Ile Lys  Lys Ile Thr Asp Thr  Gly Ile Gln 
    1205                 1210                 1215             


Lys Ile  Leu Leu Asn Tyr Leu  Lys Tyr Lys Gly Ser  Pro Glu Ile 
    1220                 1225                 1230             


Ala Phe  Ser Pro Glu Gly Leu  Glu Glu Leu Asn Lys  Asn Leu Ser 
    1235                 1240                 1245             


Ile Tyr  Asn Asp Gly Lys Pro  His Lys Pro Ile Tyr  Lys Val Arg 
    1250                 1255                 1260             


Ile Tyr  Glu Lys Gly Ser Gly  Arg Phe Ala Leu Gly  Glu Lys Gly 
    1265                 1270                 1275             


Arg Lys  Tyr Lys Lys Tyr Val  Gln Gly Ala Ser Asn  Leu Tyr Phe 
    1280                 1285                 1290             


Gly Ile  Tyr Gln Gly Ala Lys  Arg Ser Phe Ala Thr  Ile Pro Leu 
    1295                 1300                 1305             


Asn Glu  Val Ile Glu Arg Gln  Lys Gln Gly Leu Pro  Ser Val Pro 
    1310                 1315                 1320             


Glu Tyr  Asn Glu Lys Gly Asp  Leu Leu Leu Phe Ser  Leu Ser Pro 
    1325                 1330                 1335             


Asn Asp  Leu Val Tyr Val Pro  Ile Glu Gly Glu Ile  Ile Glu Asn 
    1340                 1345                 1350             


Ile Asp  Phe Arg Asn Leu Ser  Lys Glu Gln Lys Glu  Arg Ile Tyr 
    1355                 1360                 1365             


Asn Val  Asn Asp Phe Ser Ser  Thr Cys Tyr Phe Thr  Pro Asn Arg 
    1370                 1375                 1380             


Ile Ala  Lys Ala Ile Phe Pro  Lys Glu Val Asp Leu  Gln Arg Lys 
    1385                 1390                 1395             


Gly Asp  Lys Leu Ser Gly Ser  Tyr Asp Thr Lys Thr  Ala Ser Leu 
    1400                 1405                 1410             


Glu Gly  Ile Gln Ile Lys Glu  Val Cys Ile Lys Leu  Lys Val Asp 
    1415                 1420                 1425             


Arg Leu  Gly Asn Ile Ser Lys  Ala 
    1430                 1435     


<210> 152
<211> 1426
<212> PRT
<213> Capnocytophaga ochracea

<400> 152
Met Lys Asn Ile Leu Gly Leu Asp Leu Gly Thr Thr Ser Ile Gly Phe 
1               5                   10                  15      


Ala His Ile Val Glu Asp Glu Asn Lys Glu Lys Ser Glu Ile Lys Glu 
            20                  25                  30          


Leu Gly Val Arg Ile Val Ser Leu Thr Thr Asp Glu Gln Ser Asp Phe 
        35                  40                  45              


Glu Lys Gly Lys Ser Ile Thr Thr Asn Ala Asn Arg Thr Leu Lys His 
    50                  55                  60                  


Gly Ala Arg Leu Asn Leu Asp Arg Tyr Gln Gln Arg Arg Lys Tyr Leu 
65                  70                  75                  80  


Ile Asp Leu Leu Gln Lys Ala Asn Leu Ile Thr Pro Ser Ser Ile Leu 
                85                  90                  95      


Ala Glu Asn Gly Lys Asn Thr Thr His Ser Thr Trp Gln Leu Arg Ala 
            100                 105                 110         


Lys Ala Val Thr Glu Arg Ile Glu Lys Glu Glu Phe Ala Arg Ile Leu 
        115                 120                 125             


Leu Ala Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala Lys 
    130                 135                 140                 


Thr Glu Asp Glu Gly Gln Ala Ile Asp Gly Met Ala Ile Ala Lys Arg 
145                 150                 155                 160 


Leu Tyr Asp Glu Asn Leu Thr Pro Gly Gln Leu Ser Leu Gln Leu Leu 
                165                 170                 175     


Gln Gln Asn Lys Lys Leu Leu Pro Asp Phe Tyr Arg Ser Asp Leu Gln 
            180                 185                 190         


Lys Glu Phe Asp Leu Val Trp Asn Phe Gln Lys Gln Phe Tyr Pro Asp 
        195                 200                 205             


Ile Leu Thr Asp Ile Phe Tyr Lys Glu Leu Gln Gly Lys Gly Lys Asp 
    210                 215                 220                 


Ala Thr Ser Lys Ala Phe Ser Lys Arg Tyr His Phe Asp Thr Thr Glu 
225                 230                 235                 240 


Asn Lys Gly Ser Lys Glu Ser Val Arg Leu Gln Ala Tyr Gln Trp Arg 
                245                 250                 255     


Ala Glu Ala Ile Ser Lys Gln Leu Ser Lys Glu Glu Val Ala Tyr Val 
            260                 265                 270         


Leu Thr Glu Ile Asn Asn Asn Leu Asn Asn Ala Ser Gly Tyr Leu Gly 
        275                 280                 285             


Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Arg Gln Thr Val 
    290                 295                 300                 


Gly Gln Tyr Leu Tyr Ala Lys Leu Gln Glu Asn Arg His Asn Ser Leu 
305                 310                 315                 320 


Lys Asn Lys Val Phe Tyr Arg Gln Asp Tyr Leu Asp Glu Phe Glu Arg 
                325                 330                 335     


Ile Trp Glu Thr Gln Ala Ser Phe His Lys Glu Leu Thr Asp Glu Leu 
            340                 345                 350         


Lys Lys Gln Ile Arg Asp Val Val Ile Phe Tyr Gln Arg Lys Pro Lys 
        355                 360                 365             


Ser Gln Lys Gly Leu Ile Ser Phe Cys Glu Phe Glu Ser Lys Glu Ile 
    370                 375                 380                 


Glu Ile Glu Lys Asp Gly Lys Thr Ile Thr Lys Asn Ile Gly Ala Arg 
385                 390                 395                 400 


Val Val Pro Lys Ser Ser Pro Leu Phe Gln Glu Phe Lys Ile Trp Gln 
                405                 410                 415     


Ile Leu Asn Asn Val Ile Cys Lys Arg Lys Gly Ile Arg Lys Lys Lys 
            420                 425                 430         


Ile Ser Ala Lys Thr Thr Gln Leu Asp Leu Leu Asn Glu Ser Ser Gln 
        435                 440                 445             


Thr Ile Phe Ser Leu Asp Met Glu Cys Lys Gln Leu Leu Phe Asp Glu 
    450                 455                 460                 


Leu Asn Leu Lys Gly Asp Leu Lys Ser Asp Lys Val Leu Lys Leu Leu 
465                 470                 475                 480 


Gly Tyr Ser Pro Gln Glu Trp Glu Ile Asn Tyr Asn Gln Leu Glu Gly 
                485                 490                 495     


Asn Arg Thr Gln Lys Ala Leu Tyr Glu Ala Tyr Leu Lys Ile Val Glu 
            500                 505                 510         


Met Glu Ala His Asp Val Lys Asp Ile Leu Gln Ile Lys Ser Ala Lys 
        515                 520                 525             


Asp Asp Trp Ser Leu Asp Glu Ser Pro Leu Ser Ala Ser Glu Ile Arg 
    530                 535                 540                 


Glu Lys Val Lys Ala Ile Phe Gln Thr Leu Gly Ile Cys Thr Lys Ile 
545                 550                 555                 560 


Leu Tyr Phe Asp Pro Leu Leu Pro Val Lys Glu Phe Glu Glu Gln Asp 
                565                 570                 575     


Ser Tyr Gln Leu Trp His Leu Leu Tyr Ser Tyr Glu Ser Asp Asp Ser 
            580                 585                 590         


Thr Ser Gly Asn Glu Thr Leu Tyr Arg Ile Leu Glu Lys Lys Tyr Ala 
        595                 600                 605             


Phe Lys Arg Glu His Ala Arg Ile Leu Ala Asn Val Ala Leu Gln Asp 
    610                 615                 620                 


Asp Tyr Gly Ser Leu Ser Thr Lys Ala Ile Arg Lys Ile Tyr Pro Asn 
625                 630                 635                 640 


Ile Lys Glu Asn Gln Tyr Ser Thr Ala Cys Glu Lys Ala Gly Tyr Lys 
                645                 650                 655     


His Ser Lys Leu Ser Leu Thr Thr Glu Glu Leu Glu Ala Arg Glu Leu 
            660                 665                 670         


Lys Asn Ile Ile Pro Leu Leu Lys Lys Asn Ala Leu Arg Asn Pro Val 
        675                 680                 685             


Val Glu Lys Ile Leu Asn Gln Met Ile Asn Val Val Asn Ala Leu Ile 
    690                 695                 700                 


Glu Lys Asn Ser Glu Arg Asp Ala Glu Gly Lys Ile Thr Lys Tyr Phe 
705                 710                 715                 720 


His Phe Asp Glu Ile Arg Ile Glu Leu Ala Arg Glu Leu Lys Lys Asn 
                725                 730                 735     


Ala Gln Lys Arg Tyr Glu Met Thr Gln Asn Ile Asn Lys Ala Lys Leu 
            740                 745                 750         


Glu His Gln Lys Ile Ser Glu Ile Leu Gln Lys Glu Phe Gly Ile Lys 
        755                 760                 765             


Asn Pro Thr Lys Ser Asp Ile Ile Arg Tyr Arg Leu Tyr Gln Glu Leu 
    770                 775                 780                 


Glu His Asn Gly Tyr Lys Glu Leu Tyr Thr Asn Ala Pro Ile Ala Arg 
785                 790                 795                 800 


Asp Met Leu Phe Ser Lys Asn Ile Glu Ile Glu His Ile Val Pro Lys 
                805                 810                 815     


Ala Arg Val Phe Asp Asp Ser Phe Ser Asn Lys Thr Leu Thr Phe His 
            820                 825                 830         


Arg Ile Asn Ser Asp Lys Gly Glu Tyr Thr Ala Phe Asp Tyr Ile Thr 
        835                 840                 845             


Ser Leu Asn Ser Glu Glu Glu Leu Asn Gln Tyr Leu Thr Arg Val Glu 
    850                 855                 860                 


Asn Ala Tyr Lys Thr Lys Ser Ile Ser Pro Thr Lys Tyr Lys Asn Leu 
865                 870                 875                 880 


Leu Lys Lys Ala Ser Glu Ile Gly Asp Asp Phe Ile Asn Arg Asp Leu 
                885                 890                 895     


Arg Asp Thr Gln Tyr Ile Ala Lys Lys Ala Lys Glu Ile Leu Phe Gln 
            900                 905                 910         


Val Thr Lys Asn Val Leu Ser Thr Ser Gly Ser Ile Thr Asp Arg Leu 
        915                 920                 925             


Arg Glu Asp Trp Gly Leu Val Asp Val Met Lys Glu Leu Asn Met Pro 
    930                 935                 940                 


Lys Tyr Gln Ser Leu Gly Leu Thr Glu Val Glu Glu Arg Lys Asp Gly 
945                 950                 955                 960 


Asn Lys Val Thr Val Ile Lys Asn Trp Thr Lys Arg Asn Asp His Arg 
                965                 970                 975     


His His Ala Met Asp Ala Leu Thr Val Ala Phe Thr Lys Pro Ser Tyr 
            980                 985                 990         


Ile Gln Tyr Leu Asn His Leu Asn  Ala Arg Lys Asp Glu  Asn Asn Lys 
        995                 1000                 1005             


Asn Tyr  Ser Val Ile Leu Ala  Ile Glu Glu Lys Glu  Thr Ile Lys 
    1010                 1015                 1020             


Val Pro  Thr Asn Asn Gly Lys  Asn Lys Arg Val Phe  Ile Glu Pro 
    1025                 1030                 1035             


Ile Pro  Asn Phe Arg Gln Val  Ala Lys Lys His Leu  Glu Glu Ile 
    1040                 1045                 1050             


Phe Ile  Ser His Lys Ala Lys  Asn Lys Val Val Thr  Lys Asn Thr 
    1055                 1060                 1065             


Asn Lys  Pro Ala Gly Thr Asp  Lys Gln Gln Ile Thr  Leu Thr Pro 
    1070                 1075                 1080             


Arg Gly  Gln Leu His Lys Glu  Thr Ile Tyr Gly Lys  Tyr Gln Tyr 
    1085                 1090                 1095             


Tyr Ile  Asn Lys Glu Glu Lys  Ile Gly Val Lys Phe  Asp Glu Arg 
    1100                 1105                 1110             


Thr Ile  Ala Lys Val Ser Asn  Pro Val Tyr Arg Glu  Ala Leu Leu 
    1115                 1120                 1125             


Lys Arg  Leu Gln Ala Asn Asp  Asn Asp Pro Lys Lys  Ala Phe Ala 
    1130                 1135                 1140             


Gly Lys  Asn Ala Leu Ser Lys  Asn Pro Ile Tyr Leu  Asp Glu Ser 
    1145                 1150                 1155             


Lys Thr  Lys Thr Leu Pro Glu  Lys Val Asn Leu Thr  Tyr Leu Glu 
    1160                 1165                 1170             


Glu Asp  Phe Ser Ile Arg Lys  Asp Ile Ser Pro Asp  Asn Phe Lys 
    1175                 1180                 1185             


Asp Leu  Lys Ser Ile Glu Lys  Val Ile Asp Gln Gly  Val Lys Arg 
    1190                 1195                 1200             


Ile Leu  Ile Lys Arg Leu Gln  Ala Tyr Asp Asn Asp  Pro Lys Lys 
    1205                 1210                 1215             


Ala Phe  Val Asp Leu Glu Lys  Asn Pro Ile Trp Leu  Asn Lys Glu 
    1220                 1225                 1230             


Lys Gly  Ile Ala Ile Lys Arg  Val Thr Ile Ser Gly  Val Asn Asn 
    1235                 1240                 1245             


Ala Gln  Pro Leu His Ile Gly  Lys Asp His Leu Gly  Lys Thr Thr 
    1250                 1255                 1260             


Leu Asn  Lys Glu Gly Lys Glu  Ile Pro Val Asp Tyr  Val Ser Thr 
    1265                 1270                 1275             


Gly Asn  Asn His His Val Ala  Ile Tyr Arg Asp Lys  Glu Gly Asn 
    1280                 1285                 1290             


Leu Gln  Glu Gln Ile Val Ser  Phe Phe Asp Ala Val  Val Arg Ala 
    1295                 1300                 1305             


Gln Gln  Gly Ile Pro Ile Ile  Asp Lys Thr Tyr Lys  Gln Ala Glu 
    1310                 1315                 1320             


Gly Trp  Gln Phe Leu Phe Thr  Met Lys Gln Asn Glu  Met Phe Val 
    1325                 1330                 1335             


Phe Pro  Asn Ala Thr Thr Gly  Phe Asn Pro Ala Glu  Ile Asp Leu 
    1340                 1345                 1350             


Leu Asp  Pro Lys Asn Lys Lys  Leu Ile Ser Pro Asn  Leu Phe Arg 
    1355                 1360                 1365             


Val Gln  Lys Ile Ala Thr Lys  Asp Tyr Phe Phe Arg  His His Leu 
    1370                 1375                 1380             


Glu Thr  Asn Val Glu Thr Asp  Asn Ile Leu Lys Asn  Val Thr Trp 
    1385                 1390                 1395             


Lys Arg  Glu Gly Leu Ser Gly  Leu Lys Asp Ile Val  Lys Val Arg 
    1400                 1405                 1410             


Ile Asn  His Leu Gly Asp Ile  Val Ser Ile Gly Glu  Tyr 
    1415                 1420                 1425     


<210> 153
<211> 1437
<212> PRT
<213> Capnocytophaga sp.


<220>
<223> Capnocytophaga sp. CM59

<400> 153
Met Lys Tyr Ile Lys Tyr Ile Leu Gly Leu Asp Ile Gly Ser Asn Ser 
1               5                   10                  15      


Ile Gly Trp Ala Leu Ile Gln Leu Asp Leu Leu Gln Lys Thr Lys Arg 
            20                  25                  30          


Ile Ile Ala Thr Gly Ser Arg Ile Ile Pro Met Asp Gln Lys Val Leu 
        35                  40                  45              


Ser Asp Phe Gly Lys Gly Ile Thr Ile Ser Pro Thr Ala Gln Arg Thr 
    50                  55                  60                  


Ser Tyr Arg Asn Ala Arg His Cys Arg Glu Arg His Leu Leu Arg Arg 
65                  70                  75                  80  


Glu Arg Leu His Arg Val Leu His Ile Leu Gly Phe Leu Pro Thr His 
                85                  90                  95      


Tyr Asp Lys Gln Ile Asp Phe Ser Lys Arg Tyr Gly Lys Phe Val Asp 
            100                 105                 110         


Asn Thr Glu Pro Lys Ile Ala Tyr Asn Glu Arg Lys Phe Leu Phe Met 
        115                 120                 125             


Asp Ser Phe Gln Glu Met Leu Ala Asp Phe Lys Ile His Gln Pro Asp 
    130                 135                 140                 


Leu Phe Tyr Thr Lys Lys Asn Gly Glu Glu Ser Lys Ile Pro Tyr Asp 
145                 150                 155                 160 


Trp Thr Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Ser Arg Lys Ile Ser 
                165                 170                 175     


Lys Glu Glu Leu Ala Trp Ile Ile Leu Asn Phe Asn Gln Lys Arg Gly 
            180                 185                 190         


Tyr Tyr Gln Leu Arg Glu Glu Glu Glu Glu Asn Lys Glu Asn Asp Phe 
        195                 200                 205             


Glu Ile Ile Ser Ser Lys Ile Ile Ser Val Ile Lys Lys Asp Lys Asp 
    210                 215                 220                 


Lys Lys Tyr Asn Lys Tyr Trp Tyr Asp Ile Ile Leu Glu Asn Gly Leu 
225                 230                 235                 240 


Val Tyr Gln Ala Ala Phe Tyr Asn Asp Phe Val Tyr Asn Trp Ile Asn 
                245                 250                 255     


Gln Asp Arg Glu Phe Ile Ile Glu Arg Ile Ser Leu Lys Asn Gly Thr 
            260                 265                 270         


Glu Lys Val Lys Leu Ser Tyr Leu Pro Thr Phe Asp Glu Ile Asp Lys 
        275                 280                 285             


Met Asp Lys Lys Glu Gln Asp Lys Tyr Tyr Lys Lys Ile Lys Ile Lys 
    290                 295                 300                 


Thr Glu Asn Ser Ile Gly Asn Lys Thr Val Gly Cys Tyr Ile Tyr Asp 
305                 310                 315                 320 


His Ile Leu Gln Asn Pro Asn Glu Lys Ile Lys Gly Lys Leu Val Arg 
                325                 330                 335     


Thr Ile Glu Arg Lys Tyr Tyr Lys Glu Glu Leu Lys Ala Ile Leu Glu 
            340                 345                 350         


Lys Gln Val Ala Leu Gln Pro Glu Leu Phe Thr Asp Gln Leu Phe Ala 
        355                 360                 365             


Asp Cys Ile Arg Glu Leu Tyr Ser Lys Asn Glu Ala Gln Gln Arg Asn 
    370                 375                 380                 


Leu Ala Ala Arg Asp Phe Val His Leu Phe Val Glu Asp Ile Ile Phe 
385                 390                 395                 400 


Tyr Gln Arg Ser Leu Arg Arg Gln Lys Ser Thr Leu Ala Asn Cys Ser 
                405                 410                 415     


Leu Glu Ser Arg Ser Tyr Ile Asp Lys Asp Ser His Thr Arg Lys Glu 
            420                 425                 430         


Ala Pro Leu Lys Val Cys Pro Lys Ser Asn Pro Tyr Tyr Gln Glu Phe 
        435                 440                 445             


Arg Val Leu Gln Trp Leu Gln Asn Leu Lys Ile Tyr Glu Ile Asp Thr 
    450                 455                 460                 


Asp Gln Glu Val Thr His Glu Phe Ile Lys Thr Leu Glu Asp Lys Gln 
465                 470                 475                 480 


Gln Phe Phe Asp Phe Leu Met Asn Gln Lys Glu Ile Asp Cys Glu Glu 
                485                 490                 495     


Leu Leu Lys Tyr Phe Leu Asn Gln Thr Tyr Pro Asn Ala Arg Glu Lys 
            500                 505                 510         


Ala Leu Lys Ser Glu Leu Lys Lys Trp Lys Asp Thr Tyr Arg Trp Asn 
        515                 520                 525             


Tyr Val Tyr Asp Ile Gly Glu Lys Ser Ser Lys Lys Tyr Pro Met Asn 
    530                 535                 540                 


Glu Thr Arg Tyr Glu Leu Lys Arg His Leu Glu Lys Val Ala Asn Leu 
545                 550                 555                 560 


Pro Asp Asp Phe Leu Ser Ser Glu Val Glu Tyr Leu Leu Trp His Leu 
                565                 570                 575     


Ile Tyr Ser Val Lys Asp Lys Val Ala Tyr Glu Lys Gly Leu Lys Thr 
            580                 585                 590         


Phe Ala Gln Lys His His Leu Asp Lys Asp Ser Phe Val Glu Ser Phe 
        595                 600                 605             


Lys Lys Phe Lys Pro Tyr Pro Ser Glu Tyr Gly Ser Phe Ser Glu Lys 
    610                 615                 620                 


Ala Ile Arg Lys Leu Leu Pro Leu Met Arg Phe Gly Ser Tyr Trp Asp 
625                 630                 635                 640 


Phe Asn His Ile Asp Lys Asn Thr Gln Lys Arg Ile Glu Asp Leu Ile 
                645                 650                 655     


Thr Gly Val Glu Asn Glu Glu Ile Arg Thr Ile Leu Arg Glu Lys Ala 
            660                 665                 670         


Glu Lys Tyr Gln Leu Glu Lys Glu Thr Asp Phe Gln Asp Leu Pro Leu 
        675                 680                 685             


Trp Leu Ala Gln Tyr Ile Val Tyr Asn Arg His Ala Glu Ala Ser Ser 
    690                 695                 700                 


Leu Glu Lys Trp Thr Ser Val Asn Asp Leu Glu Thr Tyr Leu Asn Glu 
705                 710                 715                 720 


Phe Lys Gln Tyr Ser Leu Arg Asn Pro Ile Val Glu Gln Val Val Met 
                725                 730                 735     


Glu Thr Leu Arg Val Val Arg Asp Ile Trp Gln Gln Tyr Gly Gln Gly 
            740                 745                 750         


Gln Ala Ser Phe Phe Asp Glu Ile His Ile Glu Leu Gly Arg Glu Leu 
        755                 760                 765             


Lys Lys Thr Ala Lys Glu Arg Glu Lys Leu Ser Lys Gln Asn Gln Lys 
    770                 775                 780                 


Asn Glu Asp Ile Asn Leu Ser Ile Lys Glu Lys Leu Lys Glu Leu Glu 
785                 790                 795                 800 


Lys Tyr Asn Thr Arg Ala Tyr Ser Ile Thr His Gln Glu Lys Tyr Lys 
                805                 810                 815     


Leu Trp Leu Glu Gln Lys His Ile Ser Pro Tyr Thr Gly Gln Ile Ile 
            820                 825                 830         


Ser Pro Glu Asn Leu Phe Thr Asp Asn Tyr Glu Ile Glu His Ile Ile 
        835                 840                 845             


Pro Gln Ser Arg Phe Phe Asp Asp Ser Leu Ser Asn Lys Val Val Cys 
    850                 855                 860                 


Glu Ser Ile Val Asn Lys Ala Pro Tyr Lys Asp Arg Gln Leu Gly Leu 
865                 870                 875                 880 


Glu Phe Ile Lys Asn Gln Gly Gly Arg Ile Val Lys Glu Leu Ser Thr 
                885                 890                 895     


Glu Asn Lys Thr Ile Lys Ile Phe Thr Glu Glu Gln Tyr Arg Thr Phe 
            900                 905                 910         


Ile Lys Glu His Tyr Ser Asn Asn Pro Glu Lys Thr Lys Lys Leu Leu 
        915                 920                 925             


Leu Glu Glu Ile Pro Glu Lys Met Val Ala Arg Gln Met Asn Asp Thr 
    930                 935                 940                 


Cys Tyr Ile Ser Lys Phe Ile Ser Glu Ile Leu Ser Lys Ile Val Arg 
945                 950                 955                 960 


Ser Asp Glu Gln Asp Glu Gly Val His Ser Lys Asn Val Ile Leu Cys 
                965                 970                 975     


Thr Gly Lys Ile Thr Ser Ala Leu Lys Gln Asp Trp Gly Val Asn Asp 
            980                 985                 990         


Val Trp Asn Asp Leu Ile Leu Pro  Arg Phe Glu Arg Met  Asn Asp Leu 
        995                 1000                 1005             


Thr Gln  Ser Thr Leu Phe Thr  Thr Tyr Asn Glu Lys  Tyr Gln Lys 
    1010                 1015                 1020             


Tyr Leu  Pro Thr Val Pro Met  Glu Tyr Ser Asn Gly  Phe Gln Lys 
    1025                 1030                 1035             


Lys Arg  Ile Asp His Arg His  His Ala Met Asp Ala  Ile Ile Ile 
    1040                 1045                 1050             


Ala Cys  Ala Thr Arg Glu His  Ile Asn Tyr Ile Asn  Asn Gln His 
    1055                 1060                 1065             


Ala Leu  Glu Lys Gly Lys Asp  Lys Lys Glu Lys Gln  Lys Glu His 
    1070                 1075                 1080             


Asp Lys  Leu Arg Glu Lys Leu  Cys Ile Lys Lys Asp  Asn Lys Gly 
    1085                 1090                 1095             


Ser Glu  Glu Asn Tyr Ser Trp  Ile Phe Lys Lys Pro  Trp Asp Thr 
    1100                 1105                 1110             


Phe Thr  Gln Glu Val Gln Ala  Ala Leu Glu Gly Ile  Val Val Ser 
    1115                 1120                 1125             


Phe Lys  Gln Asn Leu Arg Val  Ile Asn Lys Ala Thr  Asn Tyr Tyr 
    1130                 1135                 1140             


Glu Arg  Trp Val Glu Glu Asn  Gly Lys Tyr Ile Lys  Lys Met Val 
    1145                 1150                 1155             


Lys Gln  Glu Gly Thr Asn Trp  Ala Ile Arg Lys Pro  Leu His Glu 
    1160                 1165                 1170             


Glu Thr  Ile Ser Gly Lys Ile  Tyr Leu Asp Arg Glu  Glu Ile Thr 
    1175                 1180                 1185             


Lys Asn  Asp Ile Leu Thr Ala  Thr Arg Lys Thr Val  Asp Ser Ser 
    1190                 1195                 1200             


Phe Asp  Glu Lys Arg Ile Lys  Lys Ile Thr Asp Thr  Gly Ile Gln 
    1205                 1210                 1215             


Lys Ile  Leu Leu Asn Tyr Leu  Lys Tyr Lys Gly Ser  Pro Glu Ile 
    1220                 1225                 1230             


Ala Phe  Ser Pro Glu Gly Leu  Glu Glu Leu Asn Lys  Asn Leu Ser 
    1235                 1240                 1245             


Ile Tyr  Asn Asp Gly Lys Pro  His Lys Pro Ile Tyr  Lys Val Arg 
    1250                 1255                 1260             


Ile Tyr  Glu Lys Gly Ser Gly  Arg Phe Ala Leu Gly  Glu Lys Gly 
    1265                 1270                 1275             


Arg Lys  Tyr Lys Lys Tyr Val  Gln Gly Ala Pro Asn  Leu Tyr Phe 
    1280                 1285                 1290             


Gly Ile  Tyr Gln Gly Ala Asn  Lys Arg Ser Phe Ala  Thr Ile Pro 
    1295                 1300                 1305             


Leu Asn  Glu Val Ile Glu Arg  Gln Lys Gln Gly Arg  Pro Ser Ile 
    1310                 1315                 1320             


Pro Glu  Tyr Asn Glu Lys Gly  Asp Pro Leu Leu Phe  Ser Leu Ser 
    1325                 1330                 1335             


Pro Asn  Asp Leu Val Tyr Val  Pro Val Glu Gly Glu  Ile Ile Glu 
    1340                 1345                 1350             


Asp Ile  Asp Phe Gln Asn Leu  Ser Lys Glu Gln Lys  Glu Arg Ile 
    1355                 1360                 1365             


Tyr Asn  Val Asn Asp Phe Ser  Ser Thr Cys Tyr Phe  Thr Pro Asn 
    1370                 1375                 1380             


Arg Ile  Ala Lys Ala Ile Phe  Pro Lys Glu Val Asp  Leu Gln Arg 
    1385                 1390                 1395             


Lys Gly  Asp Lys Leu Pro Gly  Ser Tyr Asp Thr Lys  Thr Ala Ser 
    1400                 1405                 1410             


Leu Glu  Gly Ile Gln Ile Lys  Glu Val Cys Ile Lys  Leu Lys Ile 
    1415                 1420                 1425             


Asp Arg  Leu Gly Asn Ile Ser  Lys Ala 
    1430                 1435         


<210> 154
<211> 1471
<212> PRT
<213> Capnocytophaga sp.


<220>
<223> Capnocytophaga sp. oral taxon 324 str. F0483

<400> 154
Met Cys Lys Tyr Phe Tyr Ile Lys Asn Phe Ile Thr Phe Val Leu Ser 
1               5                   10                  15      


Lys Ser Ile Ile Pro Met Lys His Ile Leu Gly Leu Asp Leu Gly Ser 
            20                  25                  30          


Asn Ser Ile Gly Trp Ala Phe Val Gln Gln Asp Phe Glu Asn Lys Gln 
        35                  40                  45              


Gly Lys Ile Ile Ala Thr Gly Ser Arg Ile Ile Pro Met Asp Gln Gly 
    50                  55                  60                  


Ile Leu Gly Asp Phe Glu Arg Gly Asn Thr Val Ser Gln Thr Ala Glu 
65                  70                  75                  80  


Arg Thr Thr Tyr Arg Ser Thr Arg Arg Leu Arg Glu Arg His Leu Leu 
                85                  90                  95      


Arg Arg Glu Arg Leu His Arg Val Leu His Ile Leu Gly Phe Leu Pro 
            100                 105                 110         


Pro His Tyr Asp Ala Gln Ile Asp Phe Thr Lys Arg Tyr Gly Lys Phe 
        115                 120                 125             


Ile Asp Asn Ala Glu Pro Lys Ile Ala Tyr Asn Asn Gly Asn Phe Ile 
    130                 135                 140                 


Phe Met Asn Ser Phe Asn Glu Met Ile Glu Asp Phe Lys Lys His Gln 
145                 150                 155                 160 


Pro Gln Leu Phe Tyr Lys Lys Ser Asn Gly Glu Glu Ser Lys Ile Pro 
                165                 170                 175     


Tyr Asp Trp Thr Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Ser Gln Lys 
            180                 185                 190         


Ile Thr Gln Gln Glu Leu Ala Trp Leu Ile Leu His Phe Asn Gln Lys 
        195                 200                 205             


Arg Gly Tyr Tyr Gln Leu Arg Gly Glu Glu Glu Thr Glu Asn Pro Asn 
    210                 215                 220                 


Lys Glu Val Ala Phe His Ser Leu Lys Val Val Asp Val Glu Ala Glu 
225                 230                 235                 240 


Ala Pro Asn Lys Lys Gly Glu Ile Trp Tyr Thr Ile Arg Leu Glu Asn 
                245                 250                 255     


Gly Trp Ile Tyr Arg Arg Thr Ser Lys Ile Pro Leu Asp Asp Trp Lys 
            260                 265                 270         


Gly Lys Thr Arg Asp Phe Ile Val Thr Thr Asp Leu Asn Asp Asp Gly 
        275                 280                 285             


Thr Ile Lys Val Asp Lys Glu Gly Lys Glu Lys Arg Ser Phe Arg Ala 
    290                 295                 300                 


Pro Asp Glu Asn Asp Trp Asn Leu Leu Lys Lys Lys Thr Glu His Asp 
305                 310                 315                 320 


Ile Asp Phe Ser Gly Lys Thr Val Gly Ala Tyr Ile Tyr Asp His Leu 
                325                 330                 335     


Leu Gln Asn Pro Asn Gln Lys Ile Lys Gly Lys Leu Val Arg Thr Ile 
            340                 345                 350         


Glu Arg Lys Tyr Tyr Lys Asp Glu Leu Lys Ala Ile Leu Ala Lys Gln 
        355                 360                 365             


Ile Ala Leu Gln Pro Glu Leu Phe Thr Glu Thr Leu Leu Ala Asp Cys 
    370                 375                 380                 


Ile Arg Glu Leu Tyr Arg Lys Asn Glu Thr Gln Gln Gln Asn Leu Leu 
385                 390                 395                 400 


Ser Lys Asp Phe Leu His Leu Phe Val Glu Asp Ile Ile Phe Tyr Gln 
                405                 410                 415     


Arg Pro Leu Arg Ser Lys Lys Ser Thr Ile Ala Asn Cys Thr Leu Glu 
            420                 425                 430         


Lys Arg Ser Tyr Ile Asp Lys Glu Thr Asn Glu Arg Lys Asp Ala Pro 
        435                 440                 445             


Ile Lys Val Cys Ala Lys Ser Asn Pro Tyr Tyr Gln Glu Phe Arg Val 
    450                 455                 460                 


Leu Gln Trp Leu Gln Asn Leu Arg Ile Tyr Glu Ile Glu Thr Asp Arg 
465                 470                 475                 480 


Glu Val Thr Ala Glu Phe Ile Glu Thr Pro Gln Asp Cys Glu Ala Leu 
                485                 490                 495     


Phe Asn Phe Leu Met Ser Gln Lys Glu Ile Asp Asn Lys Gly Leu Leu 
            500                 505                 510         


Lys Tyr Phe Leu Phe Ala Lys Asn Pro Gln Ile Lys Asp Lys Ala Ala 
        515                 520                 525             


Lys Ser Glu Leu Lys Lys Trp Leu Thr Thr Tyr Arg Trp Asn Tyr Val 
    530                 535                 540                 


Tyr Asp Ala Ala Asp Asn Ser Ser Lys Lys Tyr Pro Met Asn Glu Thr 
545                 550                 555                 560 


Gly Tyr Glu Leu Gln Arg Tyr Leu Gln Lys Val Glu Gly Leu Pro Ala 
                565                 570                 575     


Asn Phe Leu Thr Phe Asp Ile Thr Tyr Gln Leu Trp His Leu Leu Tyr 
            580                 585                 590         


Ser Val Lys Asp Lys Val Glu Phe Glu Lys Ala Leu Lys Lys Phe Ala 
        595                 600                 605             


Lys Lys Lys Gln Leu Asp Lys Thr Ser Phe Val Asp Ser Phe Lys Asn 
    610                 615                 620                 


Phe Lys Pro Tyr Pro Asn Glu Tyr Gly Ser Phe Ser Glu Lys Ala Ile 
625                 630                 635                 640 


Lys Lys Leu Leu Pro Leu Met Arg Phe Gly Asn His Trp Asp Phe Asn 
                645                 650                 655     


Arg Ile Asp Val Ser Thr Gln Lys Arg Ile Asp Asp Leu Ile Asn Gly 
            660                 665                 670         


Val Ala Asn Glu Asp Ile Arg Thr Ile Ile Arg Glu Lys Ala Glu Lys 
        675                 680                 685             


Tyr Gln Leu Asn Ser Glu Thr Cys Phe Gln Asp Leu Pro Leu Trp Leu 
    690                 695                 700                 


Ala Gln Tyr Val Val Tyr Asn Arg His Ala Glu Ala Thr Asp Ile Glu 
705                 710                 715                 720 


Lys Trp Thr Ser Val Ser Asp Leu Glu Ala Tyr Leu Glu Asp Phe Lys 
                725                 730                 735     


Gln His Ser Leu Arg Asn Pro Ile Val Glu Gln Val Val Thr Glu Thr 
            740                 745                 750         


Leu Arg Val Val Arg Asp Ile Trp Gln Gln Tyr Gly Gly Gly Gln Ala 
        755                 760                 765             


Asn Phe Phe Asp Glu Ile His Ile Glu Leu Gly Arg Glu Leu Lys Lys 
    770                 775                 780                 


Thr Ala Glu Glu Arg Lys Gln Leu Ser Asp Lys Asn Gln Glu Asn Glu 
785                 790                 795                 800 


Ser Thr Asn Leu Arg Ile Lys Lys Leu Leu Ala Glu Leu Lys Glu Asp 
                805                 810                 815     


Ala Ser Ile Gln Asn Val Arg Pro Tyr Ser Leu Val Gln Gln Glu Leu 
            820                 825                 830         


Leu Lys Ile Tyr Glu Glu Gly Val Phe Ser Ala Thr Asp Glu Val Glu 
        835                 840                 845             


Glu Asp Ile Gln Lys Ile Arg Lys Lys Ala Glu Pro Ser Lys Ala Asp 
    850                 855                 860                 


Leu Gln Arg Tyr Lys Leu Trp Leu Glu Gln Lys Tyr Lys Ser Pro Tyr 
865                 870                 875                 880 


Thr Gly Glu Val Ile Ser Leu Thr Lys Leu Phe Thr Glu Glu Tyr Glu 
                885                 890                 895     


Ile Glu His Ile Ile Pro Gln Ser Arg Tyr Tyr Asp Asp Ser Leu Ser 
            900                 905                 910         


Asn Lys Val Ile Cys Glu Ser Ala Val Asn Lys Leu Lys Thr Asn Gln 
        915                 920                 925             


Leu Gly Leu Glu Phe Ile Gln Asn His His Gly Glu Lys Val Arg Ile 
    930                 935                 940                 


Thr Ala Asn Lys Glu Val Thr Ile Phe Thr Glu Glu Gln Tyr Lys Glu 
945                 950                 955                 960 


Phe Val Lys Lys His Tyr Ala Asn Asn Ser Ala Lys Gln Gln Lys Leu 
                965                 970                 975     


Leu Leu Asn Glu Ile Pro Glu Lys Met Val Ala Arg Gln Leu Asn Asp 
            980                 985                 990         


Thr Arg Tyr Ile Ser Lys Tyr Ile  Ser Glu Ile Leu Ser  Lys Ile Val 
        995                 1000                 1005             


Arg Ser  Asp Glu Lys Asp Glu  Gly Val Asn Ser Lys  Asn Ile Ile 
    1010                 1015                 1020             


Pro Cys  Thr Gly Lys Ile Thr  Thr Ala Leu Lys Gln  Asp Trp Gly 
    1025                 1030                 1035             


Leu Asn  Asp Val Trp Asn Lys  Leu Ile Leu Pro Arg  Phe Glu Arg 
    1040                 1045                 1050             


Met Asn  Gln Leu Thr Gln Thr  Gln Leu Phe Thr Ser  Tyr Asn Asp 
    1055                 1060                 1065             


Arg Leu  Gln Lys Asn Leu Pro  Thr Val Pro Ile Glu  Tyr Ser Gln 
    1070                 1075                 1080             


Gly Phe  Gln Lys Lys Arg Ile  Asp His Arg His His  Ala Met Asp 
    1085                 1090                 1095             


Ala Leu  Val Ile Ala Cys Ala  Thr Arg Glu His Ile  Asn Tyr Met 
    1100                 1105                 1110             


Asn Asn  Gln His Ala Leu Asp  Lys Ser Lys Asp Lys  Lys Glu Lys 
    1115                 1120                 1125             


Gln Gln  Ser Arg Ile Asp Leu  Arg Thr Ile Leu Cys  Glu Lys Lys 
    1130                 1135                 1140             


Asn Asn  Asn Trp Gln Phe Lys  Lys Pro Trp Ser Thr  Phe Thr Gln 
    1145                 1150                 1155             


Glu Ala  Lys Glu Ala Leu Glu  His Ile Val Val Ser  Phe Lys Gln 
    1160                 1165                 1170             


Asn Leu  Arg Val Ile Asn Lys  Ala Thr Asn Tyr Tyr  Glu Lys Trp 
    1175                 1180                 1185             


Glu Glu  Lys Asn Gly Val Leu  Val Lys Lys Lys Val  Lys Gln Glu 
    1190                 1195                 1200             


Gly Thr  Asn Trp Ala Ile Arg  Lys Pro Leu His Lys  Glu Thr Val 
    1205                 1210                 1215             


Ser Gly  Lys Ile Val Leu Asp  Arg Lys Ile Gly Lys  Asp Lys Ile 
    1220                 1225                 1230             


Leu Thr  Ala Thr Arg Lys Ala  Val Asp Ile Thr Phe  Thr Glu Lys 
    1235                 1240                 1245             


Ile Ile  Ser Ser Ile Thr Asp  Thr Gly Ile Gln Lys  Ile Leu Leu 
    1250                 1255                 1260             


Asn Tyr  Leu Lys Tyr Lys Gly  Ser Pro Glu Val Ala  Phe Ser Thr 
    1265                 1270                 1275             


Glu Gly  Leu Glu Glu Leu Asn  Lys Asn Ile Ala Gln  Tyr Asn Asn 
    1280                 1285                 1290             


Gly Lys  Lys His Gln Pro Ile  Tyr Lys Val Arg Ile  Phe Glu Glu 
    1295                 1300                 1305             


Gly Ser  Lys Phe Pro Leu Gly  Glu Thr Gly Ala Lys  Ala Thr Lys 
    1310                 1315                 1320             


Tyr Val  Glu Ala Ala Lys Gly  Thr Asn Leu Phe Phe  Gly Val Tyr 
    1325                 1330                 1335             


Gln Gly  Lys Gly Lys Arg Thr  Tyr Ala Thr Ile Pro  Leu Asn Glu 
    1340                 1345                 1350             


Val Ile  Glu Arg Gln Lys Gln  Gly Leu Pro Ser Val  Pro Glu Arg 
    1355                 1360                 1365             


Asn Glu  Lys Gly Glu Pro Leu  Leu Phe Ser Leu Ser  Pro Asn Asp 
    1370                 1375                 1380             


Leu Val  Tyr Val Pro Met Glu  Gly Glu Ile Ala Glu  Thr Ile Asp 
    1385                 1390                 1395             


Phe Asn  Asn Leu Ser Lys Glu  Gln Lys Glu Arg Ile  Tyr Lys Thr 
    1400                 1405                 1410             


Val Ser  Phe Thr Gly Asn Gln  Cys Phe Phe Val Gln  Glu Ala Val 
    1415                 1420                 1425             


Ala Thr  Pro Ile Val Asn Lys  Met Glu Tyr Ser Pro  Leu Asn Lys 
    1430                 1435                 1440             


Met Glu  Arg Asp Ile Leu Gly  Thr Met Ile Lys Glu  Val Cys Ile 
    1445                 1450                 1455             


Lys Leu  Lys Val Asp Arg Leu  Gly Asn Ile Thr Lys  Ala 
    1460                 1465                 1470     


<210> 155
<211> 1450
<212> PRT
<213> Capnocytophaga sp.


<220>
<223> Capnocytophaga sp. oral taxon 326 str. F0382

<400> 155
Met Lys Arg Ile Leu Gly Leu Asp Leu Gly Ser Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Val Glu Gln Asp Phe Glu Asn Lys Gln Gly Lys Ile Ile Ala 
            20                  25                  30          


Thr Gly Ser Arg Ile Ile Pro Met Asp Gln Gly Ile Leu Gly Asp Phe 
        35                  40                  45              


Glu Lys Gly Asn Thr Val Ser Gln Thr Ala Glu Arg Thr Thr Tyr Arg 
    50                  55                  60                  


Ser Met Arg Arg Leu Arg Glu Arg His Leu Leu Arg Arg Glu Arg Leu 
65                  70                  75                  80  


His Arg Val Leu His Ile Leu Gly Phe Leu Pro Pro His Tyr Asp Ala 
                85                  90                  95      


Gln Ile Asp Phe Thr Lys Arg Tyr Gly Lys Phe Ile Asp Asn Ala Glu 
            100                 105                 110         


Pro Lys Ile Ala Tyr Asn Asn Gly Asn Phe Ile Phe Met Asn Ser Phe 
        115                 120                 125             


Asn Glu Met Ile Glu Asp Phe Lys Lys Tyr Gln Pro Gln Leu Phe Tyr 
    130                 135                 140                 


Lys Lys Ser Asn Gly Glu Glu Ser Lys Ile Pro Tyr Asp Trp Thr Ile 
145                 150                 155                 160 


Tyr Tyr Leu Arg Lys Lys Val Leu Ser Gln Lys Ile Thr Gln Gln Glu 
                165                 170                 175     


Leu Ala Trp Leu Ile Leu His Phe Asn Gln Lys Arg Gly Tyr Tyr Gln 
            180                 185                 190         


Leu Arg Gly Glu Glu Glu Thr Glu Asn Pro Asn Lys Glu Val Ala Phe 
        195                 200                 205             


His Ser Leu Lys Val Val Asp Val Glu Ala Glu Ala Pro Asn Lys Lys 
    210                 215                 220                 


Gly Glu Ile Trp Tyr Thr Ile Arg Leu Glu Asn Gly Trp Ile Tyr Arg 
225                 230                 235                 240 


Arg Thr Ser Lys Ile Pro Leu Asp Asp Trp Lys Gly Lys Thr Arg Asp 
                245                 250                 255     


Phe Ile Val Thr Thr Asp Leu Asn Asp Asp Gly Thr Ile Lys Val Asp 
            260                 265                 270         


Lys Glu Gly Lys Glu Lys Arg Ser Phe Arg Ala Pro Asp Glu Asn Asp 
        275                 280                 285             


Trp Asn Leu Leu Lys Lys Lys Thr Glu His Asp Ile Asp Phe Ser Gly 
    290                 295                 300                 


Lys Thr Val Gly Ala Tyr Ile Tyr Asp His Leu Leu Gln Asn Pro Asn 
305                 310                 315                 320 


Gln Lys Ile Lys Gly Lys Leu Val Arg Thr Ile Glu Arg Lys Tyr Tyr 
                325                 330                 335     


Lys Asp Glu Leu Lys Ala Ile Leu Ala Lys Gln Ile Ala Leu Gln Pro 
            340                 345                 350         


Glu Leu Phe Thr Glu Thr Leu Leu Ala Asp Cys Ile Arg Glu Leu Tyr 
        355                 360                 365             


Arg Lys Asn Glu Thr Gln Gln Gln Asn Leu Leu Ser Lys Asp Phe Leu 
    370                 375                 380                 


His Leu Phe Val Glu Asp Ile Ile Phe Tyr Gln Arg Pro Leu Arg Ser 
385                 390                 395                 400 


Lys Lys Ser Thr Ile Ala Asn Cys Thr Leu Glu Lys Arg Ser Tyr Ile 
                405                 410                 415     


Asp Lys Glu Thr Asn Glu Arg Lys Asp Thr Phe Ile Lys Val Cys Ala 
            420                 425                 430         


Lys Ser Asn Pro Tyr Tyr Gln Glu Phe Arg Val Leu Gln Trp Leu Gln 
        435                 440                 445             


Asn Leu Arg Ile Tyr Glu Ile Glu Thr Asp Arg Glu Val Thr Ala Glu 
    450                 455                 460                 


Phe Ile Glu Thr Ala Glu Asp Tyr Glu Ala Leu Phe Asn Phe Leu Met 
465                 470                 475                 480 


Ser Gln Lys Glu Ile Asp Asn Glu Gly Leu Leu Lys Tyr Phe Leu Phe 
                485                 490                 495     


Ala Lys Asn Pro Gln Ile Lys Asp Lys Val Ala Lys Ser Glu Leu Lys 
            500                 505                 510         


Lys Trp Leu Thr Thr Tyr Arg Trp Asn Tyr Val Tyr Asp Ala Ala Asp 
        515                 520                 525             


Asn Ser Ser Lys Lys Tyr Pro Met Asn Glu Thr Gly Tyr Asp Leu Gln 
    530                 535                 540                 


Arg Tyr Leu Gln Lys Val Glu Gly Leu Pro Ala Asn Phe Leu Thr Phe 
545                 550                 555                 560 


Asp Ile Thr Tyr Arg Leu Trp His Leu Leu Tyr Ser Val Lys Asp Lys 
                565                 570                 575     


Val Glu Phe Glu Lys Ala Leu Lys Lys Phe Ala Gln Glu Tyr Gln Leu 
            580                 585                 590         


Asp Glu Ala Ser Phe Val Asp Ser Phe Lys Asn Phe Lys Pro Tyr Pro 
        595                 600                 605             


Asn Glu Tyr Gly Ser Phe Ser Glu Lys Ala Ile Lys Lys Leu Leu Pro 
    610                 615                 620                 


Leu Met Arg Phe Gly Asn His Trp Asp Phe Asn Arg Ile Asp Val Ser 
625                 630                 635                 640 


Thr Gln Lys Arg Ile Asp Asp Leu Ile Asn Gly Val Ala Asn Asp Glu 
                645                 650                 655     


Ile Arg Thr Ile Ile Arg Glu Lys Ala Glu Lys Tyr Gln Leu Asn Ser 
            660                 665                 670         


Glu Ser Cys Phe Gln Gly Leu Pro Leu Trp Leu Ala Gln Tyr Val Val 
        675                 680                 685             


Tyr Asn Arg His Ala Glu Ala Thr Asp Ile Glu Lys Trp Thr Ser Val 
    690                 695                 700                 


Ser Asp Leu Glu Thr Tyr Leu Glu Asp Phe Lys Gln His Ser Leu Arg 
705                 710                 715                 720 


Asn Pro Ile Val Glu Gln Val Val Thr Glu Thr Leu Arg Val Val Arg 
                725                 730                 735     


Asp Ile Trp Gln Gln Tyr Gly Gly Gly Gln Ala Asn Phe Phe Asp Glu 
            740                 745                 750         


Ile His Ile Glu Leu Gly Arg Glu Leu Lys Lys Thr Ala Glu Glu Arg 
        755                 760                 765             


Lys Gln Leu Ser Asn Arg Asn Gln Glu Asn Glu Asn Thr Asn Leu Arg 
    770                 775                 780                 


Ile Lys Lys Leu Leu Ala Glu Leu Lys Glu Asp Ala Ser Ile Gln Asn 
785                 790                 795                 800 


Val Arg Pro Tyr Ser Pro Val Gln Gln Glu Leu Leu Lys Ile Tyr Glu 
                805                 810                 815     


Glu Gly Val Phe Ser Ser Thr Asp Gln Val Glu Glu Asp Ile Gln Lys 
            820                 825                 830         


Ile Arg Lys Lys Ala Glu Pro Thr Thr Pro Glu Ile Gln Arg Tyr Lys 
        835                 840                 845             


Leu Trp Leu Glu Gln Lys Tyr Lys Ser Pro Tyr Thr Gly Glu Val Ile 
    850                 855                 860                 


Ser Leu Thr Lys Leu Phe Thr Glu Glu Tyr Glu Ile Glu His Ile Ile 
865                 870                 875                 880 


Pro Gln Ser Arg Tyr Tyr Asp Asp Ser Leu Ser Asn Lys Val Ile Cys 
                885                 890                 895     


Glu Ser Ala Val Asn Lys Leu Lys Thr Asn Gln Leu Gly Leu Glu Phe 
            900                 905                 910         


Ile Gln Asn His His Gly Glu Lys Val Arg Ile Thr Gly Asn Lys Glu 
        915                 920                 925             


Val Thr Ile Phe Thr Glu Glu Gln Tyr Lys Glu Phe Val Lys Lys His 
    930                 935                 940                 


Tyr Ala Asn Asn Ser Ala Lys Gln Gln Lys Leu Leu Leu Asn Glu Ile 
945                 950                 955                 960 


Pro Glu Lys Met Val Ala Arg Gln Leu Asn Asp Thr Arg Tyr Ile Ser 
                965                 970                 975     


Lys Tyr Ile Ser Glu Ile Leu Ser Lys Ile Val Arg Ser Asp Glu Lys 
            980                 985                 990         


Asp Glu Gly Val Asn Ser Lys Asn  Val Ile Pro Cys Thr  Gly Lys Ile 
        995                 1000                 1005             


Thr Thr  Ala Leu Lys Gln Asp  Trp Gly Leu Asn Asp  Val Trp Asn 
    1010                 1015                 1020             


Glu Leu  Ile Leu Pro Arg Phe  Glu Arg Met Asn Gln  Leu Thr Gln 
    1025                 1030                 1035             


Thr Gln  Leu Phe Thr Ser Tyr  Asn Asp Arg Phe Gln  Lys Asn Leu 
    1040                 1045                 1050             


Pro Thr  Val Pro Ile Glu Tyr  Ser Gln Gly Phe Gln  Lys Lys Arg 
    1055                 1060                 1065             


Ile Asp  His Arg His His Ala  Met Asp Ala Leu Val  Ile Ala Cys 
    1070                 1075                 1080             


Ala Thr  Arg Glu His Ile Asn  Tyr Met Asn Asn Gln  His Ala Leu 
    1085                 1090                 1095             


Asp Lys  Asn Lys Asp Lys Lys  Glu Lys Gln Gln Ser  Arg Ile Asp 
    1100                 1105                 1110             


Leu Arg  Thr Ile Leu Cys Glu  Lys Lys Asn Asn Asn  Trp Gln Phe 
    1115                 1120                 1125             


Lys Lys  Pro Trp Ser Thr Phe  Thr Gln Glu Thr Lys  Glu Ala Leu 
    1130                 1135                 1140             


Glu His  Ile Val Val Ser Phe  Lys Gln Asn Leu Arg  Val Ile Asn 
    1145                 1150                 1155             


Lys Ala  Thr Asn Tyr Tyr Glu  Lys Trp Glu Glu Lys  Asn Gly Val 
    1160                 1165                 1170             


Leu Val  Lys Lys Lys Val Lys  Gln Glu Gly Thr Asn  Trp Ala Ile 
    1175                 1180                 1185             


Arg Lys  Pro Leu His Lys Glu  Thr Val Ser Gly Lys  Ile Val Leu 
    1190                 1195                 1200             


Asp Arg  Lys Ile Gly Lys Asp  Lys Ile Leu Thr Ala  Thr Arg Lys 
    1205                 1210                 1215             


Glu Val  Asp Ile Thr Phe Thr  Glu Lys Ile Ile Ser  Ser Ile Thr 
    1220                 1225                 1230             


Asp Thr  Gly Ile Gln Lys Ile  Leu Leu Asn Tyr Leu  Asn Tyr Lys 
    1235                 1240                 1245             


Gly Ser  Pro Glu Val Ala Phe  Ser Ala Glu Gly Leu  Glu Glu Leu 
    1250                 1255                 1260             


Asn Lys  Asn Ile Ala Gln Tyr  Asn Asp Gly Lys Lys  His Gln Pro 
    1265                 1270                 1275             


Ile Tyr  Lys Val Arg Ile Phe  Glu Glu Gly Ser Lys  Phe Pro Leu 
    1280                 1285                 1290             


Gly Glu  Thr Gly Ala Lys Ala  Thr Lys Phe Val Glu  Ala Ala Lys 
    1295                 1300                 1305             


Gly Thr  Asn Leu Phe Phe Gly  Val Tyr Gln Gly Lys  Glu Lys Arg 
    1310                 1315                 1320             


Ser Tyr  Ala Thr Ile Pro Leu  Asn Glu Val Ile Glu  Arg Gln Lys 
    1325                 1330                 1335             


Gln Gly  Leu Pro Ser Val Pro  Glu Arg Asn Glu Lys  Gly Glu Pro 
    1340                 1345                 1350             


Leu Leu  Phe Ser Leu Ser Pro  Asn Asp Leu Val Tyr  Val Pro Met 
    1355                 1360                 1365             


Glu Gly  Glu Ile Ala Glu Thr  Ile Asp Phe Asn Asn  Leu Ser Lys 
    1370                 1375                 1380             


Glu Gln  Lys Glu Arg Ile Tyr  Lys Thr Val Ser Phe  Thr Gly Asn 
    1385                 1390                 1395             


Gln Cys  Phe Phe Val Gln Glu  Ala Val Ala Thr Pro  Ile Val Asn 
    1400                 1405                 1410             


Lys Met  Glu Tyr Ser Pro Leu  Asn Lys Met Glu Arg  Asp Ile Leu 
    1415                 1420                 1425             


Gly Thr  Met Ile Lys Glu Val  Cys Ile Lys Leu Lys  Val Asp Arg 
    1430                 1435                 1440             


Leu Gly  Asn Ile Thr Lys Ala  
    1445                 1450 


<210> 156
<211> 1435
<212> PRT
<213> Capnocytophaga sp.


<220>
<223> Capnocytophaga sp. oral taxon 329 str. F0087

<400> 156
Met Lys Asn Ile Leu Gly Leu Asp Leu Gly Thr Thr Ser Ile Gly Phe 
1               5                   10                  15      


Ala His Ile Val Glu Asp Glu Asn Lys Glu Lys Ser Glu Ile Lys Glu 
            20                  25                  30          


Leu Gly Val Arg Ile Val Ser Leu Ala Thr Asp Glu Gln Ser Asp Phe 
        35                  40                  45              


Glu Lys Gly Lys Ser Ile Ser Thr Asn Ala Asn Arg Thr Leu Lys His 
    50                  55                  60                  


Gly Ala Arg Leu Asn Leu Asp Arg Tyr Gln Gln Arg Arg Lys Phe Leu 
65                  70                  75                  80  


Ile Asp Leu Leu Gln Lys Ala Asn Leu Ile Thr Ser Ala Ser Ile Leu 
                85                  90                  95      


Ala Glu Asn Gly Lys Asn Thr Thr His Ser Thr Trp Gln Leu Arg Ala 
            100                 105                 110         


Lys Ala Val Thr Glu Arg Ile Glu Lys Glu Glu Phe Ala Arg Val Leu 
        115                 120                 125             


Leu Ala Ile Asn Lys Lys Arg Gly Tyr Lys Asn Ser Arg Lys Thr Lys 
    130                 135                 140                 


Thr Glu Asp Glu Gly Gln Ala Ile Asp Gly Met Ala Ile Ala Lys Cys 
145                 150                 155                 160 


Leu Tyr Asp Glu Asn Leu Thr Pro Gly Gln Leu Ser Leu Gln Leu Leu 
                165                 170                 175     


Gln Gln Asn Lys Lys Leu Leu Pro Asp Phe Tyr Arg Ser Asp Leu Gln 
            180                 185                 190         


Lys Glu Phe Asp Leu Val Trp Asn Leu Gln Lys Gln Phe Tyr Pro Asp 
        195                 200                 205             


Ile Leu Thr Asp Ser Phe Tyr Lys Glu Leu Gln Gly Lys Gly Lys Asp 
    210                 215                 220                 


Ala Thr Ser Lys Ala Phe Ser Lys Arg Tyr His Phe Asp Thr Ala Glu 
225                 230                 235                 240 


Asn Lys Gly Ser Lys Glu Ser Val Arg Leu Gln Ala Tyr Gln Trp Arg 
                245                 250                 255     


Ala Glu Ala Ile Ser Lys Gln Leu Ser Lys Glu Glu Val Ala Tyr Val 
            260                 265                 270         


Leu Thr Glu Ile Asn Asn Asn Leu Asn Asn Ser Ser Gly Tyr Leu Gly 
        275                 280                 285             


Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Arg Gln Thr Val 
    290                 295                 300                 


Gly Gln Tyr Leu Tyr Ala Gln Leu Gln Glu Asn Arg His Asn Ser Leu 
305                 310                 315                 320 


Lys Asn Lys Val Phe Tyr Arg Gln Asp Tyr Leu Asp Glu Phe Glu Arg 
                325                 330                 335     


Ile Trp Glu Thr Gln Ala Ser Phe His Lys Glu Leu Thr Asp Glu Leu 
            340                 345                 350         


Lys Lys Gln Ile Arg Asp Val Val Ile Phe Tyr Gln Arg Lys Leu Lys 
        355                 360                 365             


Ser Gln Lys Gly Leu Val Ser Phe Cys Glu Phe Glu Ser Lys Glu Ile 
    370                 375                 380                 


Glu Ile Glu Lys Asp Gly Lys Ala Ile Thr Lys Ser Ile Gly Ala Arg 
385                 390                 395                 400 


Val Val Pro Lys Ser Ser Pro Leu Phe Gln Glu Phe Lys Ile Trp Gln 
                405                 410                 415     


Ile Leu Asn Asn Val Thr Cys Lys Arg Lys Gly Ile Arg Lys Lys Lys 
            420                 425                 430         


Ser Ser Ala Lys Ser Thr Glu Leu Asp Leu Phe Asn Glu Pro Ser Gln 
        435                 440                 445             


Ser Ile Phe Ser Leu Asp Met Glu Cys Lys Gln Leu Leu Phe Asp Glu 
    450                 455                 460                 


Leu Asn Leu Lys Gly Asp Leu Lys Ser Asp Lys Val Leu Lys Leu Leu 
465                 470                 475                 480 


Gly Tyr Ser Pro Gln Glu Trp Glu Ile Asn Tyr Asn Gln Leu Glu Gly 
                485                 490                 495     


Asn Arg Thr Gln Lys Ser Leu Tyr Glu Ala Tyr Leu Lys Ile Ile Glu 
            500                 505                 510         


Ile Glu Gly Tyr Glu Val Lys Asp Ile Leu Gln Ile Lys Ser Thr Lys 
        515                 520                 525             


Asp Asp Trp Ser Leu Asp Glu Ser Pro Leu Ser Ala Ser Glu Ile Arg 
    530                 535                 540                 


Glu Arg Val Lys Val Ile Phe Gln Thr Leu Gly Ile Cys Thr Lys Ile 
545                 550                 555                 560 


Leu Tyr Phe Asp Pro Leu Leu Pro Val Lys Glu Phe Glu Gln Gln Tyr 
                565                 570                 575     


Ser Tyr Gln Leu Trp His Leu Leu Tyr Ser Tyr Glu Ser Asp Asp Ser 
            580                 585                 590         


Thr Ser Gly Asn Glu Thr Leu Tyr Arg Ile Leu Glu Lys Lys Tyr Ala 
        595                 600                 605             


Phe Lys Arg Glu His Ala Thr Ile Leu Ala Asn Val Ala Leu Gln Asp 
    610                 615                 620                 


Asp Tyr Gly Ser Leu Ser Thr Lys Ala Ile Arg Lys Ile Tyr Pro Tyr 
625                 630                 635                 640 


Ile Lys Glu Asn Gln Tyr Ser Thr Ala Cys Glu Leu Ala Gly Tyr Lys 
                645                 650                 655     


His Ser Lys Leu Ser Leu Thr Thr Glu Glu Leu Glu Ala Arg Glu Leu 
            660                 665                 670         


Lys Asn Ile Ile Pro Leu Leu Lys Lys Asn Ala Leu Arg Asn Pro Val 
        675                 680                 685             


Val Glu Lys Ile Leu Asn Gln Met Ile Asn Val Val Asn Ala Leu Ile 
    690                 695                 700                 


Glu Lys Asn Ser Glu Arg Asp Ala Glu Gly Lys Ile Thr Lys Tyr Phe 
705                 710                 715                 720 


His Phe Asp Glu Ile Arg Ile Glu Leu Ala Arg Glu Leu Lys Lys Asn 
                725                 730                 735     


Ala Gln Glu Arg Tyr Glu Met Thr Gln Asn Ile Asn Lys Ala Lys Leu 
            740                 745                 750         


Glu His Gln Lys Ile Ser Glu Lys Leu Gln Lys Gln Phe Gly Ile Lys 
        755                 760                 765             


Asn Pro Thr Lys Ser Asp Ile Ile Arg Tyr Arg Leu Tyr Gln Glu Leu 
    770                 775                 780                 


Glu His Asn Gly Tyr Lys Glu Leu Tyr Thr Asn Thr Tyr Ile Ala Pro 
785                 790                 795                 800 


Asp Val Leu Phe Ser Lys Asn Ile Asp Ile Glu His Ile Val Pro Lys 
                805                 810                 815     


Ala Arg Val Phe Asp Asp Ser Phe Ser Asn Lys Thr Leu Ala Phe Lys 
            820                 825                 830         


Glu Phe Asn Ile Lys Lys Gly Glu Ser Thr Ala Phe Asp Tyr Ile Thr 
        835                 840                 845             


Ser Leu Asn Cys Glu Gly Glu Leu Asn Gln Tyr Leu Thr Arg Val Glu 
    850                 855                 860                 


Asn Ala Tyr Lys Thr Lys Ser Ile Ser Leu Thr Lys Tyr Lys Asn Leu 
865                 870                 875                 880 


Leu Lys Lys Ala Ser Glu Ile Gly Asp Gly Phe Ile Asn Arg Asp Leu 
                885                 890                 895     


Arg Asp Thr Gln Tyr Ile Ala Lys Lys Ala Lys Glu Ile Leu Phe Gln 
            900                 905                 910         


Val Thr Lys Asn Val Leu Ser Thr Ser Gly Ser Ile Thr Asp Arg Leu 
        915                 920                 925             


Arg Glu Asp Trp Gly Leu Val Asp Val Met Lys Glu Leu Asn Met Pro 
    930                 935                 940                 


Lys Tyr Gln Ser Leu Gly Leu Thr Glu Val Glu Glu Arg Lys Asp Gly 
945                 950                 955                 960 


Asn Lys Val Thr Val Ile Lys Asp Trp Thr Lys Arg Asn Asp His Arg 
                965                 970                 975     


His His Ala Met Asp Ala Leu Thr Val Ala Phe Thr Lys Pro Ser Tyr 
            980                 985                 990         


Ile Gln Tyr Leu Asn His Leu Asn  Ala Arg Lys Asp Glu  Asn Asn Lys 
        995                 1000                 1005             


Asn Tyr  Ser Val Ile Leu Ala  Ile Glu Lys Lys Glu  Thr Ile Lys 
    1010                 1015                 1020             


Val Pro  Ile Asn Asn Gly Lys  Asn Lys Arg Val Phe  Ile Glu Pro 
    1025                 1030                 1035             


Ile Leu  Asn Phe Arg Gln Val  Ala Lys Lys His Leu  Glu Glu Ile 
    1040                 1045                 1050             


Phe Ile  Ser His Lys Ala Lys  Asn Lys Val Val Thr  Lys Asn Ile 
    1055                 1060                 1065             


Asn Lys  Pro Ala Gly Thr Asp  Lys Gln Gln Ile Thr  Leu Thr Pro 
    1070                 1075                 1080             


Arg Gly  Gln Leu His Lys Glu  Thr Ile Tyr Gly Lys  Tyr Gln Tyr 
    1085                 1090                 1095             


Tyr Val  Asn Lys Glu Glu Lys  Val Gly Val Lys Phe  Asp Glu Arg 
    1100                 1105                 1110             


Thr Ile  Thr Lys Val Ser Asn  Pro Leu Tyr Arg Glu  Ala Leu Leu 
    1115                 1120                 1125             


Lys Arg  Leu Gln Ala Asn Asp  Asn Asp Pro Lys Lys  Ala Phe Ala 
    1130                 1135                 1140             


Gly Lys  Asn Ala Leu Ser Lys  Asn Pro Ile Tyr Leu  Asp Glu Ala 
    1145                 1150                 1155             


Lys Thr  Lys Thr Leu Pro Glu  Lys Val Asn Leu Thr  Tyr Leu Glu 
    1160                 1165                 1170             


Glu Asp  Phe Ser Ile Arg Lys  Asp Ile Ser Pro Asp  Asn Phe Lys 
    1175                 1180                 1185             


Asp Leu  Lys Ser Ile Glu Lys  Val Ile Asp Gln Gly  Val Lys Arg 
    1190                 1195                 1200             


Ile Leu  Ile Lys Arg Leu Gln  Ala Tyr Asp Asn Asp  Pro Lys Lys 
    1205                 1210                 1215             


Ala Phe  Val Asp Leu Glu Lys  Asn Pro Ile Trp Leu  Asn Lys Glu 
    1220                 1225                 1230             


Lys Gly  Ile Ala Ile Lys Arg  Val Thr Ile Ser Gly  Val Ser Asn 
    1235                 1240                 1245             


Ala Gln  Pro Leu His Ile Gly  Lys Asp His Leu Gly  Lys Thr Thr 
    1250                 1255                 1260             


Leu Asn  Lys Glu Gly Lys Glu  Val Pro Val Asp Tyr  Val Ser Thr 
    1265                 1270                 1275             


Gly Asn  Asn His His Val Ala  Ile Tyr Arg Asp Lys  Glu Gly Asn 
    1280                 1285                 1290             


Leu Gln  Glu Gln Ile Val Ser  Phe Phe Glu Ala Val  Val Arg Ala 
    1295                 1300                 1305             


Gln Gln  Gly Leu Pro Ile Ile  Asp Lys Asn Tyr Lys  Gln Ala Glu 
    1310                 1315                 1320             


Gly Trp  Gln Phe Met Phe Thr  Met Lys Gln Asn Glu  Met Phe Val 
    1325                 1330                 1335             


Phe Pro  Asn Glu Ala Thr Gly  Phe Asn Pro Ala Glu  Ile Asp Leu 
    1340                 1345                 1350             


Leu Asp  Pro Lys Asn Lys Lys  Leu Ile Ser Pro Asn  Leu Phe Arg 
    1355                 1360                 1365             


Val Gln  Thr Ile Ser Ile Val  Lys Tyr Gly Asn Ser  Val Val Arg 
    1370                 1375                 1380             


Asp Phe  Lys Phe Arg His His  Leu Glu Thr Thr Leu  Gln Asp Asp 
    1385                 1390                 1395             


Lys Ile  Leu Gln Gly Ile Thr  Phe Gln Gln Ile Lys  Ser Leu Glu 
    1400                 1405                 1410             


Pro Leu  Arg Asn Ile Val Lys  Val Arg Ile Asn His  Leu Gly Asp 
    1415                 1420                 1425             


Ile Val  Asn Ile Gly Glu Tyr  
    1430                 1435 


<210> 157
<211> 1426
<212> PRT
<213> Capnocytophaga sp.


<220>
<223> Capnocytophaga sp. oral taxon 335 str. F0486

<400> 157
Met Lys Asn Ile Leu Gly Leu Asp Leu Gly Thr Thr Ser Ile Gly Phe 
1               5                   10                  15      


Thr His Ile Val Glu Asp Glu Asn Lys Glu Lys Ser Glu Ile Lys Glu 
            20                  25                  30          


Leu Gly Val Arg Ile Val Ser Leu Thr Thr Asp Glu Gln Ser Asp Phe 
        35                  40                  45              


Glu Lys Gly Lys Ser Ile Ser Thr Asn Ala Asn Arg Thr Leu Lys His 
    50                  55                  60                  


Gly Ala Arg Leu Asn Leu Asp Arg Tyr Gln Gln Arg Arg Lys Phe Leu 
65                  70                  75                  80  


Ile Asp Leu Leu Gln Lys Ala Asn Leu Ile Thr Ser Ser Ser Ile Leu 
                85                  90                  95      


Ala Glu Asn Gly Lys Asn Thr Thr His Ser Thr Trp Gln Leu Arg Ala 
            100                 105                 110         


Lys Ala Val Thr Glu Arg Ile Glu Lys Glu Glu Phe Ala Arg Val Leu 
        115                 120                 125             


Leu Ala Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala Lys 
    130                 135                 140                 


Thr Glu Asp Glu Gly Gln Ala Ile Asp Gly Met Ala Ile Ala Lys Arg 
145                 150                 155                 160 


Leu Tyr Asp Glu Asn Leu Thr Pro Gly Gln Leu Ser Leu Gln Leu Leu 
                165                 170                 175     


Gln Gln Asn Lys Lys Leu Leu Pro Asp Phe Tyr Arg Ser Asp Leu Gln 
            180                 185                 190         


Lys Glu Phe Asp Leu Val Trp Asn Phe Gln Lys Gln Phe Tyr Pro Asp 
        195                 200                 205             


Ile Leu Thr Asp Ser Phe Tyr Lys Glu Leu Gln Gly Lys Gly Lys Asp 
    210                 215                 220                 


Ala Thr Ser Lys Ala Phe Ser Lys Arg Tyr His Phe Asp Thr Ala Glu 
225                 230                 235                 240 


Asn Lys Gly Ser Arg Glu Ser Val Arg Leu Gln Ala Tyr Gln Trp Arg 
                245                 250                 255     


Ala Glu Ala Ile Ser Lys Gln Leu Ser Lys Glu Glu Val Ala Tyr Val 
            260                 265                 270         


Leu Thr Glu Ile Asn Asn Asn Leu Asn Asn Ala Ser Gly Tyr Leu Gly 
        275                 280                 285             


Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Arg Gln Thr Val 
    290                 295                 300                 


Gly Gln Tyr Leu Tyr Ala Gln Leu Gln Glu Asn Lys His Asn Ser Leu 
305                 310                 315                 320 


Lys Asn Lys Val Phe Tyr Arg Gln Asp Tyr Leu Asp Glu Phe Glu Arg 
                325                 330                 335     


Ile Trp Glu Thr Gln Ala Ser Phe His Lys Glu Leu Thr Glu Glu Leu 
            340                 345                 350         


Lys Lys Gln Ile Arg Asp Val Val Ile Phe Tyr Gln Arg Lys Leu Lys 
        355                 360                 365             


Ser Gln Lys Gly Leu Ile Ser Phe Cys Glu Phe Glu Ser Lys Glu Ile 
    370                 375                 380                 


Glu Ile Glu Lys Asp Gly Lys Thr Ile Thr Lys Ser Ile Gly Ala Arg 
385                 390                 395                 400 


Val Val Pro Lys Ser Ser Pro Leu Phe Gln Glu Phe Lys Ile Trp Gln 
                405                 410                 415     


Ile Leu Asn Asn Val Thr Cys Lys Arg Lys Gly Ile Arg Lys Lys Lys 
            420                 425                 430         


Ser Ser Ala Lys Ser Thr Glu Leu Asp Leu Phe Asn Glu Pro Ser Gln 
        435                 440                 445             


Thr Ile Phe Ser Leu Asp Met Glu Cys Lys Gln Leu Leu Phe Glu Glu 
    450                 455                 460                 


Leu Asn Leu Lys Gly Asp Leu Lys Ser Asp Lys Val Leu Lys Leu Leu 
465                 470                 475                 480 


Gly Tyr Ser Pro Gln Glu Trp Glu Ile Asn Tyr Asn Gln Leu Glu Gly 
                485                 490                 495     


Asn Arg Thr Gln Lys Ala Leu Tyr Glu Ala Tyr Leu Lys Ile Val Glu 
            500                 505                 510         


Met Glu Ala His Asp Val Lys Asp Ile Leu Gln Ile Lys Ser Thr Lys 
        515                 520                 525             


Asp Asp Trp Ala Leu Glu Glu Ser Pro Leu Ser Ala Ser Glu Ile Arg 
    530                 535                 540                 


Glu Arg Val Lys Ala Ile Phe Gln Thr Leu Gly Ile Cys Thr Lys Ile 
545                 550                 555                 560 


Leu Tyr Phe Asp Pro Leu Leu Pro Val Lys Glu Phe Glu Glu Gln Asp 
                565                 570                 575     


Ser Tyr Gln Leu Trp His Leu Leu Tyr Ser Tyr Glu Ser Asp Asp Ser 
            580                 585                 590         


Thr Ser Gly Asn Glu Thr Leu Tyr Arg Ile Leu Glu Lys Lys Tyr Ala 
        595                 600                 605             


Phe Lys Arg Glu His Ala Thr Ile Leu Ala Asn Val Thr Leu Gln Asp 
    610                 615                 620                 


Asp Tyr Gly Ser Leu Ser Thr Lys Ala Ile Arg Lys Ile Tyr Pro Tyr 
625                 630                 635                 640 


Ile Lys Glu Asn Gln Tyr Ser Thr Ala Cys Glu Lys Ala Gly Tyr Lys 
                645                 650                 655     


His Ser Lys Leu Ser Leu Thr Thr Glu Glu Leu Glu Ala Arg Glu Leu 
            660                 665                 670         


Lys Asn Ile Ile Pro Leu Leu Lys Lys Asn Ala Leu Arg Asn Pro Val 
        675                 680                 685             


Val Glu Lys Ile Leu Asn Gln Met Ile Asn Val Val Asn Ala Leu Ile 
    690                 695                 700                 


Glu Lys Asn Ser Glu Arg Asp Ala Glu Gly Lys Ile Thr Lys Tyr Phe 
705                 710                 715                 720 


His Phe Asp Glu Ile Arg Ile Glu Leu Ala Arg Glu Leu Lys Lys Asn 
                725                 730                 735     


Ala Gln Glu Arg Tyr Glu Met Thr Gln Asn Ile Asn Lys Ala Lys Leu 
            740                 745                 750         


Glu His Gln Lys Ile Ser Gly Ile Leu Gln Lys Glu Phe Gly Ile Lys 
        755                 760                 765             


Asn Pro Thr Lys Ser Asp Ile Thr Arg Tyr Arg Leu Tyr Gln Glu Leu 
    770                 775                 780                 


Ala His Asn Gly Tyr Asn Asp Leu Tyr Thr Asn Thr Tyr Ile Pro Lys 
785                 790                 795                 800 


Glu Leu Leu Phe Ser Lys Asn Ile Asp Ile Glu His Ile Val Ser Lys 
                805                 810                 815     


Ala Arg Val Phe Asp Asp Ser Phe Ser Asn Lys Thr Leu Ala Phe Arg 
            820                 825                 830         


Glu Phe Asn Ile Lys Lys Gly Glu Ser Thr Ala Phe Asp Tyr Ile Thr 
        835                 840                 845             


Ser Leu Asn Asn Glu Glu Glu Leu Asn Gln Tyr Leu Asn Arg Val Glu 
    850                 855                 860                 


Asn Ala Tyr Lys Thr Lys Asn Ile Ser Pro Ala Lys Tyr Lys Asn Leu 
865                 870                 875                 880 


Leu Lys Lys Ala Ser Glu Ile Gly Asp Gly Phe Ile Asn Arg Asp Leu 
                885                 890                 895     


Arg Asp Thr Gln Tyr Ile Ala Lys Lys Ala Lys Glu Ile Leu Phe Gln 
            900                 905                 910         


Val Thr Lys Asn Val Leu Ser Thr Ser Gly Ser Ile Thr Asp Arg Leu 
        915                 920                 925             


Arg Glu Asp Trp Gly Leu Val Asp Val Met Lys Glu Leu Asn Met Pro 
    930                 935                 940                 


Lys Tyr Gln Ser Leu Gly Leu Thr Glu Val Glu Glu Arg Lys Glu Gly 
945                 950                 955                 960 


Asn Lys Val Thr Val Ile Lys Asn Trp Thr Lys Arg Asn Asp His Arg 
                965                 970                 975     


His His Ala Met Asp Ala Leu Thr Val Ala Phe Thr Lys Pro Ser Tyr 
            980                 985                 990         


Ile Gln Tyr Leu Asn His Leu Asn  Ala Arg Lys Asp Lys  Asn Asn Lys 
        995                 1000                 1005             


Asn Tyr  Ser Val Ile Leu Ala  Ile Glu Glu Lys Glu  Thr Ile Lys 
    1010                 1015                 1020             


Val Pro  Thr Asn Asn Gly Lys  Asn Lys Arg Val Phe  Ile Glu Pro 
    1025                 1030                 1035             


Ile Pro  Asn Phe Arg Gln Val  Ala Lys Lys His Leu  Glu Glu Ile 
    1040                 1045                 1050             


Phe Ile  Ser His Lys Ala Lys  Asn Lys Val Val Thr  Lys Asn Thr 
    1055                 1060                 1065             


Asn Lys  Pro Ala Gly Thr Asp  Lys Gln Gln Ile Thr  Leu Thr Pro 
    1070                 1075                 1080             


Arg Gly  Gln Leu His Lys Glu  Thr Val Tyr Gly Lys  Tyr Gln Tyr 
    1085                 1090                 1095             


Tyr Val  Asn Lys Glu Glu Lys  Ile Gly Val Lys Phe  Asp Lys Glu 
    1100                 1105                 1110             


Thr Ile  Ala Lys Val Ser Asn  Pro Val Tyr Arg Glu  Ala Leu Leu 
    1115                 1120                 1125             


Lys Arg  Leu Gln Ala Asn Asp  Asn Asp Pro Lys Lys  Ala Phe Ala 
    1130                 1135                 1140             


Gly Lys  Asn Ala Leu Ser Lys  Asn Pro Ile Tyr Leu  Asp Glu Ala 
    1145                 1150                 1155             


Lys Thr  Lys Thr Leu Thr Glu  Lys Val Asn Leu Thr  Tyr Leu Glu 
    1160                 1165                 1170             


Glu Asp  Phe Ser Ile Arg Lys  Asp Ile Ser Pro Asp  Asn Phe Lys 
    1175                 1180                 1185             


Asp Leu  Lys Ser Ile Glu Lys  Val Ile Asp Gln Gly  Val Lys Arg 
    1190                 1195                 1200             


Ile Leu  Ile Lys Arg Leu Gln  Asp Tyr Asp Asn Asp  Pro Lys Lys 
    1205                 1210                 1215             


Ala Phe  Val Asp Leu Glu Lys  Asn Pro Ile Trp Leu  Asn Lys Glu 
    1220                 1225                 1230             


Lys Gly  Ile Ala Ile Lys Arg  Val Thr Ile Ser Gly  Val Asn Asn 
    1235                 1240                 1245             


Ala Gln  Pro Leu His Ile Gly  Lys Asp His Leu Gly  Lys Thr Thr 
    1250                 1255                 1260             


Leu Asn  Lys Glu Gly Lys Glu  Ile Pro Val Asp Tyr  Val Ser Thr 
    1265                 1270                 1275             


Gly Asn  Asn His His Val Ala  Ile Tyr Arg Asp Lys  Glu Gly Asn 
    1280                 1285                 1290             


Leu Gln  Glu Gln Ile Val Ser  Phe Phe Glu Ala Val  Val Gly Ala 
    1295                 1300                 1305             


Gln Gln  Gly Leu Pro Ile Val  Asp Lys Thr Tyr Lys  Gln Ala Glu 
    1310                 1315                 1320             


Gly Trp  Gln Phe Leu Phe Thr  Met Lys Gln Asn Glu  Met Phe Val 
    1325                 1330                 1335             


Phe Pro  Asn Glu Ala Thr Gly  Phe Asn Pro Ala Glu  Ile Asp Leu 
    1340                 1345                 1350             


Leu Asp  Pro Lys Asn Lys Lys  Gln Ile Ser Pro Asn  Leu Phe Arg 
    1355                 1360                 1365             


Val Gln  Lys Ile Ala Thr Lys  Asp Tyr Phe Phe Arg  His His Leu 
    1370                 1375                 1380             


Glu Thr  Asn Val Asp Thr Asp  Asn Val Leu Lys Asn  Thr Thr Trp 
    1385                 1390                 1395             


Lys Arg  Glu Gly Leu Ser Gly  Leu Lys Asp Ile Val  Lys Val Arg 
    1400                 1405                 1410             


Ile Asn  His Leu Gly Asp Ile  Val Ser Ile Gly Glu  Tyr 
    1415                 1420                 1425     


<210> 158
<211> 1432
<212> PRT
<213> Capnocytophaga sp.


<220>
<223> Capnocytophaga sp. oral taxon 380 str. F0488

<400> 158
Met Lys Asn Ile Leu Gly Leu Asp Leu Gly Thr Thr Ser Ile Gly Phe 
1               5                   10                  15      


Ala His Ile Val Glu Asp Glu Asn Lys Glu Lys Ser Glu Ile Lys Glu 
            20                  25                  30          


Leu Gly Val Arg Ile Val Ser Leu Thr Thr Asp Glu Gln Ser Asp Phe 
        35                  40                  45              


Glu Lys Gly Lys Ser Ile Thr Thr Asn Ala Asn Arg Thr Leu Lys His 
    50                  55                  60                  


Gly Ala Arg Leu Asn Leu Asp Arg Tyr Gln Gln Arg Arg Lys Tyr Leu 
65                  70                  75                  80  


Ile Asp Leu Leu His Lys Ala Asn Leu Ile Thr Pro Ser Ser Ile Leu 
                85                  90                  95      


Ala Glu Asn Gly Lys Asn Thr Thr His Ser Thr Trp Gln Leu Arg Ala 
            100                 105                 110         


Lys Ala Val Thr Glu Arg Ile Glu Lys Glu Glu Phe Ala Arg Ile Leu 
        115                 120                 125             


Leu Ala Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala Lys 
    130                 135                 140                 


Thr Glu Asp Glu Gly Gln Ala Ile Asp Gly Met Ala Ile Ala Lys Arg 
145                 150                 155                 160 


Leu Tyr Asp Glu Asn Leu Thr Pro Gly Gln Leu Ser Leu Gln Leu Leu 
                165                 170                 175     


Gln Gln Asn Lys Lys Leu Leu Pro Asp Phe Tyr Arg Ser Asp Leu Gln 
            180                 185                 190         


Lys Glu Phe Asp Leu Val Trp Asn Phe Gln Lys Gln Phe Tyr Pro Asp 
        195                 200                 205             


Ile Leu Thr Asp Ile Phe Tyr Lys Glu Leu Gln Gly Lys Gly Lys Asp 
    210                 215                 220                 


Ala Thr Ser Lys Ala Phe Ser Lys Arg Tyr His Phe Asp Thr Ala Glu 
225                 230                 235                 240 


Asn Lys Gly Ser Lys Glu Ser Val Arg Leu Gln Ala Tyr Gln Trp Arg 
                245                 250                 255     


Ala Glu Ala Val Ser Lys Gln Leu Ser Lys Glu Glu Val Ala Tyr Val 
            260                 265                 270         


Leu Thr Glu Ile Asn Asn Asn Leu Asn Asn Ala Ser Gly Tyr Leu Gly 
        275                 280                 285             


Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Arg Gln Thr Val 
    290                 295                 300                 


Gly Gln Tyr Leu Tyr Ala Gln Leu Gln Glu Asn Arg His Asn Ser Leu 
305                 310                 315                 320 


Lys Asn Lys Val Phe Tyr Arg Gln Asp Tyr Leu Asp Glu Phe Glu Arg 
                325                 330                 335     


Ile Trp Glu Thr Gln Ala Leu Phe His Lys Glu Leu Thr Asp Glu Leu 
            340                 345                 350         


Lys Lys Gln Ile Arg Asp Val Val Ile Phe Tyr Gln Arg Lys Pro Lys 
        355                 360                 365             


Ser Gln Lys Gly Leu Ile Ser Phe Cys Glu Phe Glu Ser Lys Glu Ile 
    370                 375                 380                 


Glu Ile Glu Lys Asp Gly Lys Thr Ile Thr Lys Asn Ile Gly Ala Arg 
385                 390                 395                 400 


Val Val Pro Lys Ser Ser Pro Leu Phe Gln Glu Phe Lys Ile Trp Gln 
                405                 410                 415     


Ile Leu Asn Asn Val Ile Cys Lys Arg Lys Gly Ile Arg Lys Lys Lys 
            420                 425                 430         


Ile Ser Ala Lys Thr Thr Gln Leu Asp Leu Leu Asn Glu Ser Ser Gln 
        435                 440                 445             


Thr Ile Phe Ser Leu Asp Met Glu Cys Lys Gln Leu Leu Phe Asp Glu 
    450                 455                 460                 


Leu Asn Leu Lys Gly Asp Leu Lys Ser Asp Lys Val Leu Lys Leu Leu 
465                 470                 475                 480 


Gly Tyr Ser Pro Gln Glu Trp Glu Ile Asn Tyr Asn Gln Leu Glu Gly 
                485                 490                 495     


Asn Arg Thr Gln Lys Ala Leu Tyr Glu Ala Tyr Leu Lys Ile Val Glu 
            500                 505                 510         


Met Glu Ala His Asp Val Lys Asp Ile Leu Gln Ile Lys Ser Thr Lys 
        515                 520                 525             


Asp Asp Trp Ser Leu Asp Glu Ser Pro Leu Ser Ala Ser Glu Ile Arg 
    530                 535                 540                 


Glu Ser Val Lys Ala Ile Phe Gln Ala Leu Gly Ile Cys Thr Lys Ile 
545                 550                 555                 560 


Leu Tyr Phe Asp Pro Leu Leu Pro Val Lys Asp Phe Glu Glu Gln Asp 
                565                 570                 575     


Ser Tyr Gln Leu Trp His Leu Leu Tyr Ser Tyr Glu Ser Asp Asp Ser 
            580                 585                 590         


Thr Ser Gly Asn Glu Thr Leu Tyr Arg Ile Leu Glu Lys Lys Tyr Ala 
        595                 600                 605             


Phe Lys Arg Glu His Ala Arg Ile Leu Ala Asn Val Ala Leu Gln Asp 
    610                 615                 620                 


Asp Tyr Gly Ser Leu Ser Thr Lys Ala Ile Arg Lys Ile Tyr Pro Asn 
625                 630                 635                 640 


Ile Lys Glu Asn Gln Tyr Ser Thr Ala Cys Glu Met Ala Gly Tyr Lys 
                645                 650                 655     


His Ser Lys Leu Ser Leu Thr Thr Glu Glu Leu Glu Ala Arg Glu Leu 
            660                 665                 670         


Lys Asn Ile Ile Pro Leu Leu Lys Lys Asn Ala Leu Arg Asn Pro Val 
        675                 680                 685             


Val Glu Lys Ile Leu Asn Gln Met Ile Asn Val Val Asn Ala Leu Ile 
    690                 695                 700                 


Glu Lys Asn Ser Glu Arg Asp Ala Glu Gly Lys Ile Thr Lys Tyr Phe 
705                 710                 715                 720 


His Phe Asp Glu Ile Arg Ile Glu Leu Ala Arg Glu Leu Lys Lys Asn 
                725                 730                 735     


Ala Gln Lys Arg Tyr Glu Met Thr Gln Asn Ile Asn Lys Ala Lys Ser 
            740                 745                 750         


Glu His Gln Lys Ile Ser Glu Ile Leu Gln Lys Glu Phe Gly Ile Lys 
        755                 760                 765             


Asn Pro Thr Lys Ser Asp Ile Ile Arg Tyr Arg Leu Tyr Lys Glu Leu 
    770                 775                 780                 


Glu His Asn Gly Tyr Lys Glu Leu Tyr Thr Asn Thr Tyr Ile Ala Pro 
785                 790                 795                 800 


Asp Val Leu Phe Ser Lys Asn Ile Asp Ile Glu His Ile Val Pro Lys 
                805                 810                 815     


Ala Arg Val Phe Asp Asp Ser Phe Ser Asn Lys Thr Leu Ala Phe Lys 
            820                 825                 830         


Asp Phe Asn Ile Lys Lys Gly Glu Ser Thr Ala Phe Asp Tyr Ile Thr 
        835                 840                 845             


Ser Leu Lys Asn Glu Glu Lys Leu Asn Gln Tyr Leu Ala Arg Val Glu 
    850                 855                 860                 


Asn Ala Tyr Lys Thr Lys Asn Ile Ser Pro Ala Lys Tyr Lys Asn Leu 
865                 870                 875                 880 


Leu Lys Lys Ala Ser Glu Ile Gly Asp Gly Phe Ile Asn Arg Asp Leu 
                885                 890                 895     


Arg Asp Thr Gln Tyr Ile Ala Lys Lys Ala Lys Glu Ile Leu Phe Gln 
            900                 905                 910         


Val Thr Lys Asn Val Leu Ser Thr Ser Gly Ser Ile Thr Asp Arg Leu 
        915                 920                 925             


Arg Glu Asp Trp Ser Leu Val Asp Val Met Lys Glu Leu Asn Met Pro 
    930                 935                 940                 


Lys Tyr Gln Ser Leu Gly Leu Thr Glu Val Glu Glu Arg Lys Asp Gly 
945                 950                 955                 960 


Asn Lys Val Thr Val Ile Lys Asp Trp Thr Lys Arg Asn Asp His Arg 
                965                 970                 975     


His His Ala Met Asp Ala Leu Thr Val Ala Phe Thr Lys Pro Ser Tyr 
            980                 985                 990         


Ile Gln Tyr Leu Asn His Leu Asn  Ala Arg Lys Asp Glu  Asn Asn Lys 
        995                 1000                 1005             


Asn Tyr  Ser Val Ile Leu Ala  Ile Glu Lys Lys Glu  Thr Ile Lys 
    1010                 1015                 1020             


Val Pro  Thr Asn Asn Gly Lys  Asn Lys Arg Val Phe  Ile Glu Pro 
    1025                 1030                 1035             


Ile Pro  Asn Phe Arg Gln Val  Ala Lys Lys His Leu  Glu Glu Ile 
    1040                 1045                 1050             


Phe Ile  Ser His Lys Ala Lys  Asn Lys Val Val Thr  Lys Asn Thr 
    1055                 1060                 1065             


Asn Lys  Pro Ala Gly Thr Asn  Lys Gln Gln Ile Thr  Leu Thr Pro 
    1070                 1075                 1080             


Arg Gly  Gln Leu His Lys Glu  Thr Ile Tyr Gly Lys  Tyr Gln Tyr 
    1085                 1090                 1095             


Tyr Val  Asn Lys Glu Glu Lys  Val Gly Val Lys Phe  Asp Lys Glu 
    1100                 1105                 1110             


Thr Ile  Ala Lys Val Ser Asn  Pro Leu Tyr Arg Glu  Ala Leu Leu 
    1115                 1120                 1125             


Lys Arg  Leu Gln Ala Asn Asp  Asn Asp Pro Lys Lys  Ala Phe Thr 
    1130                 1135                 1140             


Gly Lys  Asn Ala Leu Ser Lys  Asn Pro Ile Tyr Leu  Asp Glu Ala 
    1145                 1150                 1155             


Lys Thr  Lys Thr Leu Pro Glu  Lys Val Asn Leu Thr  Tyr Leu Glu 
    1160                 1165                 1170             


Glu Asp  Phe Ser Val Arg Lys  Lys Ile Val Pro Lys  Asn Pro Thr 
    1175                 1180                 1185             


Ser Lys  Glu Phe Val Pro Asn  Leu Lys Ser Ile Glu  Lys Val Val 
    1190                 1195                 1200             


Asp Glu  Gly Val Arg Asn Ile  Leu Ile Glu Arg Leu  Arg Val Tyr 
    1205                 1210                 1215             


Asn Asn  Asp Pro Glu Lys Ala  Phe Val Asp Leu Glu  Lys Asn Pro 
    1220                 1225                 1230             


Ile Trp  Leu Asn Lys Glu Lys  Gly Ile Ala Ile Lys  Arg Val Thr 
    1235                 1240                 1245             


Ile Ser  Gly Val Asn Asn Ala  Gln Pro Leu His Ile  Gly Lys Asp 
    1250                 1255                 1260             


His Leu  Gly Lys Thr Thr Leu  Asn Lys Glu Gly Lys  Glu Ile Pro 
    1265                 1270                 1275             


Val Asp  Tyr Val Ser Thr Gly  Asn Asn His His Val  Ala Ile Tyr 
    1280                 1285                 1290             


Arg Asp  Lys Glu Gly Asn Leu  Gln Glu Gln Ile Val  Ser Phe Phe 
    1295                 1300                 1305             


Glu Ala  Val Val Arg Thr Gln  Gln Gly Leu Pro Ile  Ile Asp Lys 
    1310                 1315                 1320             


Thr Tyr  Lys Gln Glu Glu Gly  Trp Gln Phe Leu Phe  Thr Met Lys 
    1325                 1330                 1335             


Gln Asn  Glu Met Phe Val Phe  Pro Asn Glu Ala Thr  Gly Phe Asn 
    1340                 1345                 1350             


Pro Ala  Glu Ile Asp Leu Leu  Asp Pro Lys Asn Lys  Lys Gln Ile 
    1355                 1360                 1365             


Ser Pro  Asn Leu Phe Arg Val  Gln Lys Ile Ala Thr  Lys Asp Tyr 
    1370                 1375                 1380             


Phe Phe  Arg His His Leu Glu  Thr Asn Val Glu Thr  Asp Asn Val 
    1385                 1390                 1395             


Leu Lys  Asn Thr Thr Trp Lys  Arg Glu Gly Leu Ser  Gly Leu Lys 
    1400                 1405                 1410             


Asp Ile  Val Lys Val Arg Ile  Asn His Leu Gly Asp  Ile Val Ser 
    1415                 1420                 1425             


Ile Gly  Glu Tyr 
    1430         


<210> 159
<211> 1450
<212> PRT
<213> Capnocytophaga sp.


<220>
<223> Capnocytophaga sp. oral taxon 412 str. F0487

<400> 159
Met Lys His Ile Leu Gly Leu Asp Leu Gly Ser Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Val Gln Gln Asp Phe Glu Asn Lys Gln Gly Lys Ile Ile Ala 
            20                  25                  30          


Thr Gly Ser Arg Ile Ile Pro Met Asp Gln Gly Ile Leu Gly Asp Phe 
        35                  40                  45              


Glu Arg Gly Asn Thr Val Ser Gln Thr Ala Glu Arg Thr Thr Tyr Arg 
    50                  55                  60                  


Asn Thr Arg Arg Leu Arg Glu Arg His Leu Leu Arg Arg Glu Arg Leu 
65                  70                  75                  80  


His Arg Val Leu His Ile Leu Gly Phe Leu Pro Pro His Tyr Asp Ser 
                85                  90                  95      


Gln Ile Asp Phe Thr Lys Arg Tyr Gly Lys Phe Ile Asp Asn Ala Glu 
            100                 105                 110         


Pro Lys Ile Ala Tyr Asn Asn Gly Asn Phe Ile Phe Met Asn Ser Phe 
        115                 120                 125             


Asn Glu Met Ile Glu Asp Phe Lys Lys Tyr Gln Pro Gln Leu Phe Tyr 
    130                 135                 140                 


Lys Lys Ser Asn Gly Glu Glu Ser Lys Ile Pro Tyr Asp Trp Thr Ile 
145                 150                 155                 160 


Tyr Tyr Leu Arg Lys Lys Ala Leu Ser Gln Lys Ile Thr Gln Gln Glu 
                165                 170                 175     


Leu Ala Trp Leu Ile Leu His Phe Asn Gln Lys Arg Gly Tyr Tyr Gln 
            180                 185                 190         


Leu Arg Gly Glu Glu Glu Thr Glu Asn Pro Asn Lys Glu Val Ala Phe 
        195                 200                 205             


His Ser Leu Glu Val Val Asp Val Glu Ala Glu Ala Pro Asn Lys Lys 
    210                 215                 220                 


Gly Glu Ile Trp Tyr Thr Ile Arg Leu Glu Asn Gly Trp Ile Tyr Arg 
225                 230                 235                 240 


Arg Thr Ser Lys Ile Pro Leu Asp Asp Trp Lys Gly Lys Thr Arg Asp 
                245                 250                 255     


Phe Ile Val Thr Thr Asp Leu Asn Asp Asp Gly Thr Ile Lys Leu Asp 
            260                 265                 270         


Lys Glu Gly Lys Glu Lys Arg Ser Phe Arg Ala Pro Asp Glu Asn Asp 
        275                 280                 285             


Trp Asn Leu Leu Lys Lys Lys Thr Glu His Asp Ile Asp Phe Ser Gly 
    290                 295                 300                 


Lys Thr Val Gly Ala Tyr Ile Tyr Asp His Leu Leu Gln Asn Pro Asn 
305                 310                 315                 320 


Gln Lys Ile Lys Gly Lys Leu Val Arg Thr Ile Glu Arg Lys Tyr Tyr 
                325                 330                 335     


Lys Asp Glu Leu Lys Ala Ile Leu Ala Lys Gln Ile Ala Leu Gln Pro 
            340                 345                 350         


Glu Leu Phe Thr Glu Thr Leu Leu Ala Asp Cys Ile Arg Glu Leu Tyr 
        355                 360                 365             


Arg Lys Asn Glu Thr Gln Gln Gln Asn Leu Leu Ser Lys Asp Phe Leu 
    370                 375                 380                 


His Leu Phe Val Glu Asp Ile Ile Phe Tyr Gln Arg Pro Leu Arg Ser 
385                 390                 395                 400 


Lys Lys Ser Thr Ile Ala Asn Cys Thr Leu Glu Lys Arg Ser Tyr Ile 
                405                 410                 415     


Asp Lys Glu Thr Asn Glu Arg Lys Asp Thr Pro Ile Lys Val Cys Ala 
            420                 425                 430         


Lys Ser Asn Pro Tyr Tyr Gln Glu Phe Arg Val Leu Gln Trp Leu Gln 
        435                 440                 445             


Asn Leu Arg Ile Tyr Glu Ile Glu Thr Asp Arg Glu Val Thr Ala Glu 
    450                 455                 460                 


Phe Ile Glu Thr Ala Gln Asp Asn Glu Ala Leu Phe Asn Phe Leu Met 
465                 470                 475                 480 


Ser Gln Lys Glu Ile Asp Asn Glu Ser Leu Leu Lys Tyr Phe Leu Phe 
                485                 490                 495     


Ala Lys Asn Pro Gln Ile Lys Asp Lys Val Ala Lys Ser Glu Leu Lys 
            500                 505                 510         


Lys Trp Leu Thr Thr Tyr Arg Trp Asn Tyr Val Tyr Asp Ala Ala Asp 
        515                 520                 525             


Asn Ser Ser Lys Lys Tyr Pro Met Asn Glu Thr Gly Tyr Glu Leu Gln 
    530                 535                 540                 


Gln Tyr Leu Gln Lys Val Glu Gly Leu Pro Ala Asn Phe Leu Thr Phe 
545                 550                 555                 560 


Asp Ile Thr Tyr Arg Leu Trp His Leu Leu Tyr Ser Val Lys Asp Lys 
                565                 570                 575     


Val Glu Phe Glu Lys Ala Leu Lys Lys Phe Ala Gln Glu Tyr Gln Leu 
            580                 585                 590         


Asp Glu Ala Ser Phe Val Asp Ser Phe Lys Asn Phe Lys Pro Tyr Pro 
        595                 600                 605             


Asn Glu Tyr Gly Ser Phe Ser Glu Lys Ala Ile Lys Lys Leu Leu Pro 
    610                 615                 620                 


Leu Met Arg Phe Gly Asn His Trp Asp Phe Asn Arg Ile Asp Val Ser 
625                 630                 635                 640 


Thr Gln Lys Arg Ile Asp Asp Leu Ile Asn Gly Val Ala Asn Asp Glu 
                645                 650                 655     


Ile Arg Thr Ile Ile Arg Glu Lys Ala Glu Lys Tyr Gln Leu Asn Ser 
            660                 665                 670         


Glu Thr Cys Phe Gln Gly Leu Pro Leu Trp Leu Ala Gln Tyr Val Val 
        675                 680                 685             


Tyr Asn Arg His Ala Glu Ala Ala Asp Ile Glu Lys Trp Thr Ser Val 
    690                 695                 700                 


Asn Asp Leu Glu Ala Tyr Leu Glu Asp Phe Lys Gln His Ser Leu Arg 
705                 710                 715                 720 


Asn Pro Ile Val Glu Gln Val Ile Thr Glu Thr Leu Arg Val Val Arg 
                725                 730                 735     


Asp Ile Trp Gln Arg Tyr Gly Gly Gly Gln Ala Asn Phe Phe Asp Glu 
            740                 745                 750         


Ile His Ile Glu Leu Gly Arg Glu Leu Lys Lys Thr Ala Glu Glu Arg 
        755                 760                 765             


Lys Gln Leu Ser Asn Arg Asn Gln Glu Asn Glu Asn Thr Asn Leu Arg 
    770                 775                 780                 


Ile Lys Lys Leu Leu Ala Glu Leu Lys Glu Asp Ala Ser Ile Gln Asn 
785                 790                 795                 800 


Val Arg Pro Tyr Ser Pro Val Gln Gln Glu Leu Leu Lys Ile Tyr Glu 
                805                 810                 815     


Glu Gly Val Phe Ser Ala Thr Asp Glu Val Glu Glu Asp Ile Gln Lys 
            820                 825                 830         


Ile Arg Lys Lys Ala Glu Pro Thr Thr Pro Glu Ile Gln Arg Tyr Lys 
        835                 840                 845             


Leu Trp Leu Glu Gln Lys Tyr Lys Ser Pro Tyr Thr Gly Glu Val Ile 
    850                 855                 860                 


Ser Leu Thr Lys Leu Phe Thr Glu Glu Tyr Glu Ile Glu His Ile Ile 
865                 870                 875                 880 


Pro Gln Ser Arg Tyr Tyr Asp Asp Ser Leu Ser Asn Lys Val Ile Cys 
                885                 890                 895     


Glu Ser Ala Val Asn Lys Leu Lys Thr Asn Gln Leu Gly Leu Glu Phe 
            900                 905                 910         


Ile Gln Asn His His Gly Glu Lys Val Arg Ile Thr Ala Asn Lys Glu 
        915                 920                 925             


Val Thr Ile Phe Thr Glu Glu Gln Tyr Lys Glu Phe Val Lys Lys His 
    930                 935                 940                 


Tyr Ala Asn Asn Ser Ala Lys Gln Gln Lys Leu Leu Leu Asn Glu Ile 
945                 950                 955                 960 


Pro Glu Lys Met Val Ala Arg Gln Leu Asn Asp Thr Arg Tyr Ile Ser 
                965                 970                 975     


Lys Tyr Ile Ser Glu Ile Leu Ser Lys Ile Val Arg Ser Asp Glu Lys 
            980                 985                 990         


Asp Glu Gly Val Asn Ser Lys Asn  Ile Ile Pro Cys Thr  Gly Lys Ile 
        995                 1000                 1005             


Thr Thr  Ala Leu Lys Gln Asp  Trp Gly Leu Asn Asp  Val Trp Asn 
    1010                 1015                 1020             


Glu Leu  Ile Leu Pro Arg Phe  Glu Arg Met Asn Gln  Leu Thr Gln 
    1025                 1030                 1035             


Thr Gln  Leu Phe Thr Ser Tyr  Asn Asp Arg Phe Gln  Lys Asn Leu 
    1040                 1045                 1050             


Pro Thr  Val Pro Ile Glu Tyr  Ser Gln Gly Phe Gln  Lys Lys Arg 
    1055                 1060                 1065             


Ile Asp  His Arg His His Ala  Met Asp Ala Leu Val  Ile Ala Cys 
    1070                 1075                 1080             


Ala Thr  Arg Glu His Ile Asn  Tyr Met Asn Asn Gln  His Ala Leu 
    1085                 1090                 1095             


Asp Lys  Ser Lys Asp Lys Lys  Glu Lys Gln Gln Ser  Arg Ile Asp 
    1100                 1105                 1110             


Leu Arg  Thr Ile Leu Cys Glu  Lys Lys Asn Asn Asn  Trp Gln Phe 
    1115                 1120                 1125             


Lys Lys  Pro Trp Ser Thr Phe  Thr Gln Glu Ala Gln  Glu Ala Leu 
    1130                 1135                 1140             


Glu His  Ile Val Val Ser Phe  Lys Gln Asn Leu Arg  Val Ile Asn 
    1145                 1150                 1155             


Lys Ala  Thr Asn Tyr Tyr Glu  Lys Trp Glu Glu Lys  Asn Gly Val 
    1160                 1165                 1170             


Leu Val  Lys Lys Lys Val Lys  Gln Glu Gly Thr Asn  Trp Ala Ile 
    1175                 1180                 1185             


Arg Lys  Pro Leu His Lys Glu  Thr Val Ser Gly Lys  Ile Val Leu 
    1190                 1195                 1200             


Asp Arg  Lys Ile Gly Lys Asp  Lys Ile Leu Thr Ala  Thr Arg Lys 
    1205                 1210                 1215             


Ser Val  Asp Ile Thr Phe Thr  Glu Lys Ile Ile Ser  Ser Ile Thr 
    1220                 1225                 1230             


Asp Thr  Gly Ile Gln Lys Ile  Leu Leu Asn Tyr Leu  Lys Tyr Lys 
    1235                 1240                 1245             


Gly Ser  Pro Glu Val Ala Phe  Ser Ala Glu Gly Leu  Glu Glu Leu 
    1250                 1255                 1260             


Asn Lys  Asn Ile Ala Gln Tyr  Asn Asp Gly Lys Lys  His Gln Pro 
    1265                 1270                 1275             


Ile Tyr  Lys Val Arg Ile Phe  Glu Glu Gly Ser Lys  Phe Pro Leu 
    1280                 1285                 1290             


Gly Glu  Thr Gly Ala Lys Ala  Thr Lys Tyr Val Glu  Ala Ala Lys 
    1295                 1300                 1305             


Gly Thr  Asn Leu Phe Phe Gly  Val Tyr Gln Gly Lys  Gly Lys Arg 
    1310                 1315                 1320             


Thr Tyr  Ala Thr Ile Pro Leu  Asn Glu Val Ile Glu  Arg Gln Lys 
    1325                 1330                 1335             


Gln Gly  Leu Pro Ser Val Pro  Glu Arg Asn Glu Lys  Gly Glu Pro 
    1340                 1345                 1350             


Leu Leu  Phe Ser Leu Ser Pro  Asn Asp Leu Val Tyr  Val Pro Met 
    1355                 1360                 1365             


Glu Gly  Glu Ile Ala Glu Thr  Ile Asp Phe Asn Asn  Leu Ser Lys 
    1370                 1375                 1380             


Glu Gln  Lys Glu Arg Ile Tyr  Lys Thr Val Ser Phe  Thr Gly Asn 
    1385                 1390                 1395             


Gln Cys  Phe Phe Val Gln Glu  Ala Val Ala Thr Pro  Ile Val Asn 
    1400                 1405                 1410             


Lys Ile  Glu Tyr Ser Pro Leu  Asn Lys Met Glu Arg  Asp Ile Leu 
    1415                 1420                 1425             


Gly Thr  Met Ile Lys Glu Val  Cys Ile Lys Leu Lys  Val Asp Arg 
    1430                 1435                 1440             


Leu Gly  Asn Ile Thr Lys Ala  
    1445                 1450 


<210> 160
<211> 1426
<212> PRT
<213> Capnocytophaga sputigena


<220>
<223> Capnocytophaga sputigena ATCC 33612

<400> 160
Met Lys Asn Ile Leu Gly Leu Asp Leu Gly Ile Thr Ser Ile Ser Phe 
1               5                   10                  15      


Ala His Ile Val Glu Asp Glu Asn Lys Glu Lys Ser Glu Ile Lys Glu 
            20                  25                  30          


Leu Gly Val Arg Ile Val Ser Leu Thr Thr Asp Glu Gln Ser Asp Phe 
        35                  40                  45              


Glu Lys Gly Lys Ser Ile Thr Thr Asn Ala Asn Arg Thr Leu Lys His 
    50                  55                  60                  


Gly Ala Arg Leu Asn Leu Asp Arg Tyr Gln Gln Arg Arg Lys Tyr Leu 
65                  70                  75                  80  


Ile Asp Leu Leu Gln Lys Ala Asn Leu Ile Thr Ser Ser Ser Ile Leu 
                85                  90                  95      


Ala Glu Asn Gly Lys Asn Thr Thr His Ser Thr Trp Gln Leu Arg Ala 
            100                 105                 110         


Lys Ala Val Thr Glu Arg Ile Glu Lys Glu Glu Phe Ala Arg Val Leu 
        115                 120                 125             


Leu Ala Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala Lys 
    130                 135                 140                 


Thr Glu Asp Glu Gly Gln Ala Ile Asp Gly Met Ala Ile Ala Lys Arg 
145                 150                 155                 160 


Leu Tyr Asp Glu Asn Leu Thr Pro Gly Gln Leu Ser Leu Gln Leu Leu 
                165                 170                 175     


Gln Gln Asn Lys Lys Leu Leu Pro Asp Phe Tyr Arg Ser Asp Leu Gln 
            180                 185                 190         


Arg Glu Phe Asp Leu Val Trp Asn Phe Gln Lys Gln Phe Tyr Pro Asp 
        195                 200                 205             


Ile Leu Thr Asp Ser Phe Tyr Lys Glu Leu Gln Gly Lys Gly Lys Asp 
    210                 215                 220                 


Ala Thr Ser Lys Ala Phe Ser Lys Arg Tyr His Phe Asp Thr Ala Glu 
225                 230                 235                 240 


Asn Lys Gly Ser Lys Glu Ser Val Arg Leu Gln Ala Tyr Gln Trp Arg 
                245                 250                 255     


Ala Glu Ala Ile Ser Lys Gln Leu Ser Lys Glu Glu Val Ala Tyr Val 
            260                 265                 270         


Leu Thr Glu Ile Asn Asn Asn Leu Asn Asn Ala Ser Gly Tyr Leu Gly 
        275                 280                 285             


Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Arg Gln Thr Val 
    290                 295                 300                 


Gly Gln Tyr Leu Tyr Ala Gln Leu Gln Glu Asn Arg His Asn Ser Leu 
305                 310                 315                 320 


Lys Asn Lys Val Phe Tyr Arg Gln Asp Tyr Leu Asp Glu Phe Glu Arg 
                325                 330                 335     


Ile Trp Glu Thr Gln Ala Ser Phe His Lys Glu Leu Thr Asp Glu Leu 
            340                 345                 350         


Lys Lys Gln Ile Arg Asp Val Val Ile Phe Tyr Gln Arg Lys Leu Lys 
        355                 360                 365             


Ser Gln Lys Gly Leu Ile Ser Phe Cys Glu Phe Glu Ser Lys Glu Ile 
    370                 375                 380                 


Glu Ile Glu Lys Asp Gly Lys Thr Ile Thr Lys Thr Ile Gly Ala Arg 
385                 390                 395                 400 


Val Val Pro Lys Ser Ser Pro Leu Phe Gln Glu Phe Lys Ile Trp Gln 
                405                 410                 415     


Ile Leu Asn Asn Val Thr Cys Lys Arg Lys Gly Ile Arg Lys Lys Lys 
            420                 425                 430         


Ser Ser Ala Lys Ser Thr Glu Leu Asp Leu Phe Asn Glu Pro Ser Gln 
        435                 440                 445             


Thr Ile Phe Ser Leu Asp Met Glu Cys Lys Gln Leu Leu Phe Asp Glu 
    450                 455                 460                 


Leu Asn Leu Lys Gly Asp Leu Lys Ser Asp Lys Val Leu Lys Leu Leu 
465                 470                 475                 480 


Gly Tyr Ser Pro Gln Glu Trp Glu Ile Asn Tyr Asn Gln Leu Glu Gly 
                485                 490                 495     


Asn Arg Thr Gln Lys Ala Leu Tyr Glu Ala Tyr Leu Lys Ile Val Glu 
            500                 505                 510         


Met Glu Ala His Asp Val Lys Asp Ile Leu Gln Ile Lys Ser Ala Lys 
        515                 520                 525             


Asp Asp Trp Ser Leu Asp Glu Ser Pro Leu Ser Ala Ser Glu Ile Lys 
    530                 535                 540                 


Glu Lys Val Lys Asp Ile Phe Gln Ala Leu Gly Ile Cys Thr Lys Ile 
545                 550                 555                 560 


Leu Tyr Phe Asp Pro Leu Leu Pro Val Lys Glu Phe Glu Lys Gln Asp 
                565                 570                 575     


Ser Tyr Gln Leu Trp His Leu Leu Tyr Ser Tyr Glu Ser Asp Asp Ser 
            580                 585                 590         


Thr Ser Gly Asn Glu Thr Leu Tyr Arg Ile Leu Glu Lys Lys Tyr Ala 
        595                 600                 605             


Phe Lys Arg Glu His Ala Arg Ile Leu Ala Asn Val Ala Leu Gln Asp 
    610                 615                 620                 


Asp Tyr Gly Ser Leu Ser Thr Lys Ala Ile Arg Lys Ile Tyr Pro Asn 
625                 630                 635                 640 


Ile Lys Glu Asn Gln Tyr Ser Lys Ala Cys Glu Leu Ala Gly Tyr Lys 
                645                 650                 655     


His Ser Lys Leu Ser Leu Thr Thr Glu Glu Leu Glu Ala Arg Glu Leu 
            660                 665                 670         


Lys Asn Ile Ile Pro Leu Leu Lys Lys Asn Ala Leu Arg Asn Pro Val 
        675                 680                 685             


Val Glu Lys Ile Leu Asn Gln Met Ile Asn Val Val Asn Ala Leu Ile 
    690                 695                 700                 


Glu Lys Asn Ser Glu Arg Asp Ala Glu Gly Lys Ile Thr Lys Tyr Phe 
705                 710                 715                 720 


His Phe Asp Glu Ile Arg Ile Glu Leu Ala Arg Glu Leu Lys Lys Asn 
                725                 730                 735     


Ala Gln Lys Arg Tyr Glu Met Thr Gln Asn Ile Asn Lys Ala Lys Leu 
            740                 745                 750         


Glu His Gln Lys Ile Ser Glu Ile Leu Gln Lys Lys Phe Gly Ile Lys 
        755                 760                 765             


Asn Pro Thr Lys Ser Asp Ile Ile Arg Tyr Arg Leu Tyr Gln Glu Leu 
    770                 775                 780                 


Glu His Asn Gly Tyr Lys Glu Leu Tyr Thr Asn Ala Pro Ile Ala Arg 
785                 790                 795                 800 


Asp Met Leu Phe Ser Lys Asn Ile Glu Ile Glu His Ile Val Pro Lys 
                805                 810                 815     


Ala Arg Val Phe Asp Asp Ser Phe Ser Asn Lys Thr Leu Thr Phe His 
            820                 825                 830         


Arg Ile Asn Ser Asn Lys Gly Glu Tyr Thr Ala Phe Asp Tyr Ile Thr 
        835                 840                 845             


Ser Leu Asn Ser Glu Glu Glu Leu Asn Gln Tyr Leu Thr Arg Val Glu 
    850                 855                 860                 


Asn Ala Tyr Lys Thr Lys Ser Ile Ser Leu Thr Lys Tyr Lys Asn Leu 
865                 870                 875                 880 


Leu Lys Lys Ala Ser Glu Ile Gly Asp Gly Phe Ile Asn Arg Asp Leu 
                885                 890                 895     


Arg Asp Thr Gln Tyr Ile Ala Lys Lys Ala Lys Glu Ile Leu Phe Gln 
            900                 905                 910         


Val Thr Lys Asn Val Leu Ser Thr Ser Gly Ser Ile Thr Asp Arg Leu 
        915                 920                 925             


Arg Glu Asp Trp Gly Leu Val Asp Val Met Lys Glu Leu Asn Met Pro 
    930                 935                 940                 


Lys Tyr Gln Ser Leu Gly Leu Thr Glu Val Glu Glu Arg Lys Glu Gly 
945                 950                 955                 960 


Asn Lys Val Thr Val Ile Lys Asn Trp Thr Lys Arg Asn Asp His Arg 
                965                 970                 975     


His His Ala Met Asp Ala Leu Thr Val Ala Phe Thr Lys Pro Ser Tyr 
            980                 985                 990         


Ile Gln Tyr Leu Asn His Leu Asn  Ala Arg Lys Asp Glu  Asn Asn Lys 
        995                 1000                 1005             


Asn Tyr  Ser Val Ile Leu Ala  Ile Glu Glu Lys Glu  Thr Ile Lys 
    1010                 1015                 1020             


Val Pro  Thr Asn Asn Gly Lys  Asn Lys Arg Val Phe  Ile Glu Pro 
    1025                 1030                 1035             


Ile Pro  Asn Phe Arg Gln Val  Ala Lys Lys His Leu  Glu Glu Ile 
    1040                 1045                 1050             


Phe Ile  Ser His Lys Ala Lys  Asn Lys Val Val Thr  Lys Asn Val 
    1055                 1060                 1065             


Asn Lys  Pro Ala Gly Thr Asp  Lys Gln Gln Ile Thr  Leu Thr Pro 
    1070                 1075                 1080             


Arg Gly  Gln Leu His Lys Glu  Thr Ile Tyr Gly Lys  Tyr Gln Tyr 
    1085                 1090                 1095             


Tyr Val  Asn Lys Glu Glu Lys  Val Gly Val Lys Phe  Asp Glu Arg 
    1100                 1105                 1110             


Thr Ile  Thr Lys Val Ser Asn  Pro Leu Tyr Arg Glu  Ala Leu Leu 
    1115                 1120                 1125             


Lys Arg  Leu Gln Ala Asn Asp  Asn Asp Pro Lys Lys  Ala Phe Thr 
    1130                 1135                 1140             


Gly Lys  Asn Ala Leu Ser Lys  Asn Pro Ile Tyr Leu  Asp Glu Thr 
    1145                 1150                 1155             


Lys Thr  Lys Thr Leu Pro Glu  Lys Val Asn Leu Thr  Tyr Leu Glu 
    1160                 1165                 1170             


Glu Asp  Phe Ser Ile Arg Lys  Asp Ile Ser Pro Asp  Asn Phe Lys 
    1175                 1180                 1185             


Asp Leu  Lys Ser Ile Glu Lys  Val Ile Asp Gln Gly  Val Lys Arg 
    1190                 1195                 1200             


Ile Leu  Ile Lys Arg Leu Gln  Asp Tyr Asp Asn Asp  Pro Lys Lys 
    1205                 1210                 1215             


Ala Phe  Val Asp Leu Glu Lys  Asn Pro Ile Trp Leu  Asn Lys Glu 
    1220                 1225                 1230             


Lys Gly  Ile Ala Ile Lys Arg  Val Thr Ile Ser Gly  Val Ser Asn 
    1235                 1240                 1245             


Ala Gln  Pro Leu His Ile Gly  Lys Asp His Leu Gly  Lys Thr Thr 
    1250                 1255                 1260             


Leu Asn  Lys Glu Gly Asn Glu  Ile Pro Val Asp Tyr  Val Ser Thr 
    1265                 1270                 1275             


Gly Asn  Asn His His Val Ala  Ile Tyr Arg Asp Lys  Glu Gly Asn 
    1280                 1285                 1290             


Leu Gln  Glu Gln Ile Val Ser  Phe Phe Glu Ala Val  Val Arg Thr 
    1295                 1300                 1305             


Gln Gln  Gly Leu Pro Ile Ile  Asp Lys Thr Tyr Lys  Gln Glu Glu 
    1310                 1315                 1320             


Gly Trp  Gln Phe Leu Phe Thr  Met Lys Gln Asn Glu  Met Phe Val 
    1325                 1330                 1335             


Phe Pro  Asn Ala Thr Thr Gly  Phe Asn Pro Ala Glu  Ile Asp Leu 
    1340                 1345                 1350             


Leu Asp  Pro Lys Asn Lys Lys  Leu Ile Ser Pro Asn  Leu Phe Arg 
    1355                 1360                 1365             


Val Gln  Lys Ile Ala Thr Lys  Asp Tyr Phe Phe Arg  His His Leu 
    1370                 1375                 1380             


Glu Thr  Asn Val Glu Thr Asp  Asn Val Leu Lys Asn  Thr Thr Trp 
    1385                 1390                 1395             


Lys Arg  Glu Gly Leu Ser Gly  Leu Lys Asp Ile Val  Lys Val Arg 
    1400                 1405                 1410             


Ile Asn  His Leu Gly Asp Ile  Val Ser Ile Gly Glu  Tyr 
    1415                 1420                 1425     


<210> 161
<211> 1140
<212> PRT
<213> Catellicoccus marimammalium


<220>
<223> Catellicoccus marimammalium M35/04/3

<400> 161
Met Lys Asn Met Thr Lys Val Asn Val Gly Leu Asp Val Gly Ile Ser 
1               5                   10                  15      


Ser Ala Gly Trp Ser Val Ile Asn Ala Glu Thr Asn Gln Ile Leu Glu 
            20                  25                  30          


Ser Gly Val Arg Leu Phe Ser Gly Ser Asp Ala Asp Glu Asn Val Asn 
        35                  40                  45              


Arg Arg Asn Gln Arg Gln Gly Arg Arg Leu Phe Arg Arg Arg Lys Leu 
    50                  55                  60                  


Arg Ile Gln Glu Ala Lys Lys Tyr Leu Glu Asn Val Phe Gln Leu Lys 
65                  70                  75                  80  


Asp Ile Glu Pro Lys Asp Glu Trp Asn Pro Tyr Glu Ile Arg Val Arg 
                85                  90                  95      


Ala Leu Asn Glu Lys Val Ser Lys Glu Glu Leu Ser Ile Ala Leu Leu 
            100                 105                 110         


Asn Ile Val Lys His Arg Gly Ile Ser Tyr Glu Leu Glu Asp Val Thr 
        115                 120                 125             


Asp Glu Glu Gly Thr Asn Thr Gln Ser Phe Gln Ser Gly Leu Asp Tyr 
    130                 135                 140                 


Asn Arg Arg Leu Leu Lys Thr Lys Thr Val Gly Glu Ile Gln Tyr Asp 
145                 150                 155                 160 


Arg Leu Gln Lys Tyr Gly Gln Val Arg Gly Gln Ile Gln Thr Glu Asp 
                165                 170                 175     


Gly Leu Leu Ile Asn Ile Phe Pro Thr Lys Asn Tyr Val Glu Glu Val 
            180                 185                 190         


Glu Arg Ile Leu Glu Thr Gln Lys Lys Tyr His Pro Glu Ile Asp Asp 
        195                 200                 205             


Val Phe Ile Glu Lys Ile Ile Ser Phe Val Thr Arg Lys Arg Glu Tyr 
    210                 215                 220                 


Phe Val Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Ile Tyr 
225                 230                 235                 240 


Arg Glu Asn Gly Glu Thr Leu Asp Asn Leu Phe Glu Ile Leu Ile Gly 
                245                 250                 255     


Lys Asp Lys Phe Tyr Pro Glu Glu Tyr Arg Ala Ala Gly Ser Ser Tyr 
            260                 265                 270         


Thr Ala Gln Ile Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Pro Thr Thr Glu Asp His His Leu Thr Lys Ala Gln Lys Glu Glu Ile 
    290                 295                 300                 


Ile Thr Glu Leu Lys Asn Thr Ser Arg Leu Ser Gly Gly Met Leu Lys 
305                 310                 315                 320 


Leu Ile Ser Lys Val Thr Lys Ala Pro Lys Glu Glu Ile Ser Gly Tyr 
                325                 330                 335     


Arg Lys Asp Glu Lys Asp Lys Pro Asp Leu His Ser Leu Ala Tyr Tyr 
            340                 345                 350         


Arg Lys Gln Lys Asn Met Leu Glu Lys Glu Gly Ile Gln Ile Ala Asp 
        355                 360                 365             


Phe Ser Glu Glu Leu Leu Asp Glu Leu Ala Thr Met Met Thr Leu Asn 
    370                 375                 380                 


Thr Glu Pro Gly Glu Ile Arg Lys Gln Leu Asn Lys Ile Thr Asn Gln 
385                 390                 395                 400 


Tyr Asp Ile Leu Thr Pro Glu Val Ile Glu Val Leu Val Lys Asn His 
                405                 410                 415     


Thr Ala Phe Val Ala Thr Ser Asn His Lys Trp His Arg Phe Ser Leu 
            420                 425                 430         


Lys Leu Met Lys Glu Phe Ile Pro Glu Leu Leu Glu Thr Ser Lys Glu 
        435                 440                 445             


Gln Ser Thr Ile Leu Cys Glu Arg Gly Phe Ile Gln Asn Arg Ala Ser 
    450                 455                 460                 


Tyr Leu Asp Glu Asn His His Phe Asn Tyr Ala Glu Leu Arg Glu Asn 
465                 470                 475                 480 


Leu Tyr Asn Pro Val Val Arg Lys Ser Thr Cys Glu Met Leu Lys Val 
                485                 490                 495     


Phe Thr Ala Ile Gln Glu Lys Tyr Pro Asn Ile Gln Asn Val Ile Val 
            500                 505                 510         


Glu Leu Pro Arg Glu Thr Asn Glu Asp Glu Gln Lys Arg Lys Ile Lys 
        515                 520                 525             


Lys Ile Asn Asp Asn Asn Ala Lys Arg Lys Lys Glu Ile Leu Lys Glu 
    530                 535                 540                 


Ala Gln Ala Gln Ser Gly Leu Ser Glu Glu Ala Leu Glu Glu Lys Leu 
545                 550                 555                 560 


Leu Lys Thr Lys Gly Leu Tyr Leu Lys Leu Met Leu Trp Tyr Glu Gln 
                565                 570                 575     


Glu Gly Lys Cys Val Tyr Ser Gly Gln Glu Ile Pro Leu Ser Asp Leu 
            580                 585                 590         


Leu Gln Asn Lys Gly Gly Tyr Glu Val Asp His Ile Ile Pro Ile Ser 
        595                 600                 605             


Ile Ser Phe Asp Asp Arg Leu Cys Asn Lys Val Leu Val Arg Gln Gln 
    610                 615                 620                 


Leu Asn Ser Gln Lys Ser Asn Gln Thr Pro Phe Glu Tyr Met Thr Thr 
625                 630                 635                 640 


His Thr Asp Gly His Leu Ser Phe His Glu Leu Lys Glu Leu Val Gly 
                645                 650                 655     


Lys Asn Lys Arg Phe Ser Lys Glu Lys Arg Glu Leu Leu Leu Ala Glu 
            660                 665                 670         


Ile Tyr Ser Asn Asp Ile Glu Thr Arg Lys Arg Phe Ile Asn Arg Asn 
        675                 680                 685             


Leu Val Asp Thr Ser Tyr Thr Ala Arg Ile Val Leu Asn Ala Leu Gln 
    690                 695                 700                 


Gln Tyr Lys Lys Glu Asn Gln Leu Ser Met Asn Val Ser Val Val Arg 
705                 710                 715                 720 


Gly Ala Met Thr Asn Ile Leu Arg Lys Lys Val Lys Leu Asp Lys Thr 
                725                 730                 735     


Arg Glu Thr Phe His His His Ala Ile Asp Ala Ser Leu Met Ala Val 
            740                 745                 750         


Ile Pro Asn Ile Glu Phe Phe Lys Glu Arg Lys Glu Trp Leu Pro Lys 
        755                 760                 765             


Ser Ala Asn Glu Glu Val Val Glu Val Glu Val Ser Glu Glu Glu Thr 
    770                 775                 780                 


Met Pro Glu Lys Glu Phe Lys Val Lys Met Arg Leu Pro Glu Ser Phe 
785                 790                 795                 800 


Ile Gln Asp Val Gln Ile Leu Gln Arg Asn Ser Phe Ala Lys Glu Glu 
                805                 810                 815     


Val Ser Gly Pro Gln Thr Arg Glu Arg Asn Leu Lys Ile Lys Phe Ser 
            820                 825                 830         


His Gln Val Asp Gln Lys Met Asn Arg Lys Val Ala Asp Asp Thr Ile 
        835                 840                 845             


Tyr Gly Thr Arg Gln Ala Gln Leu Gly Lys Asp Lys Lys Glu Glu Thr 
    850                 855                 860                 


Tyr Val Ile Gly Lys Ile Lys Asp Ile Tyr Asn Tyr Asp Glu Tyr Val 
865                 870                 875                 880 


Arg Phe Lys Lys Arg Tyr Asp Lys Asn Lys Glu Ser Phe Leu Met Tyr 
                885                 890                 895     


His His Asp Pro Gln Thr Phe Glu Lys Leu Glu Glu Ile Leu Ala Gln 
            900                 905                 910         


Tyr Pro Glu Tyr Ile Glu Asp Glu Lys Gly Lys Lys Lys Lys Val Ser 
        915                 920                 925             


Pro Phe Ala Leu Tyr Arg Glu Glu Asn Gly Pro Val Thr Lys Tyr Ala 
    930                 935                 940                 


Lys Lys Asn Asn Gly Pro Val Ile Lys Gln Leu Lys Tyr Tyr Asp Ser 
945                 950                 955                 960 


Lys Leu Asn Arg Lys Ile Asp Ile Ser His Lys Tyr Ser Thr Lys Asn 
                965                 970                 975     


Arg Gln Val Val Leu Gln Ser Leu Lys Pro Tyr Arg Thr Asp Val Tyr 
            980                 985                 990         


Arg Asn Gln Asp Thr Gly Glu Tyr  Thr Leu Val Gly Ile  Asp Gln Asn 
        995                 1000                 1005             


Asp Gly  Lys Phe Val Asn Gly  His Tyr Gly Ile Pro  Lys Ser Arg 
    1010                 1015                 1020             


Tyr Glu  Glu Ile Lys Ala Asn  Asn Lys Leu Ser Glu  His Asp Glu 
    1025                 1030                 1035             


Phe Val  Phe Ser Leu Tyr Lys  Asn Ser Met Val Lys  Val Ile Asp 
    1040                 1045                 1050             


Glu Asn  Gly Glu Ser Ile Val  Val Arg Tyr Leu Ser  Arg Ser Met 
    1055                 1060                 1065             


Pro Asn  Arg Lys Asn Asn Ala  Glu Ile Lys Pro Val  Glu Lys Tyr 
    1070                 1075                 1080             


Gln Phe  Glu Asp Gly Glu Val  Val Pro Val Tyr Gly  Lys Cys Arg 
    1085                 1090                 1095             


Lys Gln  Met Gln Thr Val Phe  Val Lys Lys Gly Trp  Thr Leu Leu 
    1100                 1105                 1110             


Lys Gly  Asn Thr Asp Ile Leu  Gly Asn Thr Tyr Phe  Val Glu Lys 
    1115                 1120                 1125             


Glu Ser  Glu Asn Pro Lys Lys  Met Ile Asp Asp Lys  
    1130                 1135                 1140 


<210> 162
<211> 1329
<212> PRT
<213> Catenibacterium mitsuokai


<220>
<223> Catenibacterium mitsuokai DSM 15897

<400> 162
Ile Val Asp Tyr Cys Ile Gly Leu Asp Leu Gly Thr Gly Ser Val Gly 
1               5                   10                  15      


Trp Ala Val Val Asp Met Asn His Arg Leu Met Lys Arg Asn Gly Lys 
            20                  25                  30          


His Leu Trp Gly Ser Arg Leu Phe Ser Asn Ala Glu Thr Ala Ala Asn 
        35                  40                  45              


Arg Arg Ala Ser Arg Ser Ile Arg Arg Arg Tyr Asn Lys Arg Arg Glu 
    50                  55                  60                  


Arg Ile Arg Leu Leu Arg Ala Ile Leu Gln Asp Met Val Leu Glu Lys 
65                  70                  75                  80  


Asp Pro Thr Phe Phe Ile Arg Leu Glu His Thr Ser Phe Leu Asp Glu 
                85                  90                  95      


Glu Asp Lys Ala Lys Tyr Leu Gly Thr Asp Tyr Lys Asp Asn Tyr Asn 
            100                 105                 110         


Leu Phe Ile Asp Glu Asp Phe Asn Asp Tyr Thr Tyr Tyr His Lys Tyr 
        115                 120                 125             


Pro Thr Ile Tyr His Leu Arg Lys Ala Leu Cys Glu Ser Thr Glu Lys 
    130                 135                 140                 


Ala Asp Pro Arg Leu Ile Tyr Leu Ala Leu His His Ile Val Lys Tyr 
145                 150                 155                 160 


Arg Gly Asn Phe Leu Tyr Glu Gly Gln Lys Phe Asn Met Asp Ala Ser 
                165                 170                 175     


Asn Ile Glu Asp Lys Leu Ser Asp Ile Phe Thr Gln Phe Thr Ser Phe 
            180                 185                 190         


Asn Asn Ile Pro Tyr Glu Asp Asp Glu Lys Lys Asn Leu Glu Ile Leu 
        195                 200                 205             


Glu Ile Leu Lys Lys Pro Leu Ser Lys Lys Ala Lys Val Asp Glu Val 
    210                 215                 220                 


Met Thr Leu Ile Ala Pro Glu Lys Asp Tyr Lys Ser Ala Phe Lys Glu 
225                 230                 235                 240 


Leu Val Thr Gly Ile Ala Gly Asn Lys Met Asn Val Thr Lys Met Ile 
                245                 250                 255     


Leu Cys Glu Pro Ile Lys Gln Gly Asp Ser Glu Ile Lys Leu Lys Phe 
            260                 265                 270         


Ser Asp Ser Asn Tyr Asp Asp Gln Phe Ser Glu Val Glu Lys Asp Leu 
        275                 280                 285             


Gly Glu Tyr Val Glu Phe Val Asp Ala Leu His Asn Val Tyr Ser Trp 
    290                 295                 300                 


Val Glu Leu Gln Thr Ile Met Gly Ala Thr His Thr Asp Asn Ala Ser 
305                 310                 315                 320 


Ile Ser Glu Ala Met Val Ser Arg Tyr Asn Lys His His Asp Asp Leu 
                325                 330                 335     


Lys Leu Leu Lys Asp Cys Ile Lys Asn Asn Val Pro Asn Lys Tyr Phe 
            340                 345                 350         


Asp Met Phe Arg Asn Asp Ser Glu Lys Ser Lys Gly Tyr Tyr Asn Tyr 
        355                 360                 365             


Ile Asn Arg Pro Ser Lys Ala Pro Val Asp Glu Phe Tyr Lys Tyr Val 
    370                 375                 380                 


Lys Lys Cys Ile Glu Lys Val Asp Thr Pro Glu Ala Lys Gln Ile Leu 
385                 390                 395                 400 


Asn Asp Ile Glu Leu Glu Asn Phe Leu Leu Lys Gln Asn Ser Arg Thr 
                405                 410                 415     


Asn Gly Ser Val Pro Tyr Gln Met Gln Leu Asp Glu Met Ile Lys Ile 
            420                 425                 430         


Ile Asp Asn Gln Ala Glu Tyr Tyr Pro Ile Leu Lys Glu Lys Arg Glu 
        435                 440                 445             


Gln Leu Leu Ser Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Phe Gly Pro 
    450                 455                 460                 


Leu Asn Glu Thr Ser Glu His Ala Trp Ile Lys Arg Leu Glu Gly Lys 
465                 470                 475                 480 


Glu Asn Gln Arg Ile Leu Pro Trp Asn Tyr Gln Asp Ile Val Asp Val 
                485                 490                 495     


Asp Ala Thr Ala Glu Gly Phe Ile Lys Arg Met Arg Ser Tyr Cys Thr 
            500                 505                 510         


Tyr Phe Pro Asp Glu Glu Val Leu Pro Lys Asn Ser Leu Ile Val Ser 
        515                 520                 525             


Lys Tyr Glu Val Tyr Asn Glu Leu Asn Lys Ile Arg Val Asp Asp Lys 
    530                 535                 540                 


Leu Leu Glu Val Asp Val Lys Asn Asp Ile Tyr Asn Glu Leu Phe Met 
545                 550                 555                 560 


Lys Asn Lys Thr Val Thr Glu Lys Lys Leu Lys Asn Trp Leu Val Asn 
                565                 570                 575     


Asn Gln Cys Cys Ser Lys Asp Ala Glu Ile Lys Gly Phe Gln Lys Glu 
            580                 585                 590         


Asn Gln Phe Ser Thr Ser Leu Thr Pro Trp Ile Asp Phe Thr Asn Ile 
        595                 600                 605             


Phe Gly Lys Ile Asp Gln Ser Asn Phe Asp Leu Ile Glu Asn Ile Ile 
    610                 615                 620                 


Tyr Asp Leu Thr Val Phe Glu Asp Lys Lys Ile Met Lys Arg Arg Leu 
625                 630                 635                 640 


Lys Lys Lys Tyr Ala Leu Pro Asp Asp Lys Val Lys Gln Ile Leu Lys 
                645                 650                 655     


Leu Lys Tyr Lys Asp Trp Ser Arg Leu Ser Lys Lys Leu Leu Asp Gly 
            660                 665                 670         


Ile Val Ala Asp Asn Arg Phe Gly Ser Ser Val Thr Val Leu Asp Val 
        675                 680                 685             


Leu Glu Met Ser Arg Leu Asn Leu Met Glu Ile Ile Asn Asp Lys Asp 
    690                 695                 700                 


Leu Gly Tyr Ala Gln Met Ile Glu Glu Ala Thr Ser Cys Pro Glu Asp 
705                 710                 715                 720 


Gly Lys Phe Thr Tyr Glu Glu Val Glu Arg Leu Ala Gly Ser Pro Ala 
                725                 730                 735     


Leu Lys Arg Gly Ile Trp Gln Ser Leu Gln Ile Val Glu Glu Ile Thr 
            740                 745                 750         


Lys Val Met Lys Cys Arg Pro Lys Tyr Ile Tyr Ile Glu Phe Glu Arg 
        755                 760                 765             


Ser Glu Glu Ala Lys Glu Arg Thr Glu Ser Lys Ile Lys Lys Leu Glu 
    770                 775                 780                 


Asn Val Tyr Lys Asp Leu Asp Glu Gln Thr Lys Lys Glu Tyr Lys Ser 
785                 790                 795                 800 


Val Leu Glu Glu Leu Lys Gly Phe Asp Asn Thr Lys Lys Ile Ser Ser 
                805                 810                 815     


Asp Ser Leu Phe Leu Tyr Phe Thr Gln Leu Gly Lys Cys Met Tyr Ser 
            820                 825                 830         


Gly Lys Lys Leu Asp Ile Asp Ser Leu Asp Lys Tyr Gln Ile Asp His 
        835                 840                 845             


Ile Val Pro Gln Ser Leu Val Lys Asp Asp Ser Phe Asp Asn Arg Val 
    850                 855                 860                 


Leu Val Val Pro Ser Glu Asn Gln Arg Lys Leu Asp Asp Leu Val Val 
865                 870                 875                 880 


Pro Phe Asp Ile Arg Asp Lys Met Tyr Arg Phe Trp Lys Leu Leu Phe 
                885                 890                 895     


Asp His Glu Leu Ile Ser Pro Lys Lys Phe Tyr Ser Leu Ile Lys Thr 
            900                 905                 910         


Glu Tyr Thr Glu Arg Asp Glu Glu Arg Phe Ile Asn Arg Gln Leu Val 
        915                 920                 925             


Glu Thr Arg Gln Ile Thr Lys Asn Val Thr Gln Ile Ile Glu Asp His 
    930                 935                 940                 


Tyr Ser Thr Thr Lys Val Ala Ala Ile Arg Ala Asn Leu Ser His Glu 
945                 950                 955                 960 


Phe Arg Val Lys Asn His Ile Tyr Lys Asn Arg Asp Ile Asn Asp Tyr 
                965                 970                 975     


His His Ala His Asp Ala Tyr Ile Val Ala Leu Ile Gly Gly Phe Met 
            980                 985                 990         


Arg Asp Arg Tyr Pro Asn Met His  Asp Ser Lys Ala Val  Tyr Ser Glu 
        995                 1000                 1005             


Tyr Met  Lys Met Phe Arg Lys  Asn Lys Asn Asp Gln  Lys Arg Trp 
    1010                 1015                 1020             


Lys Asp  Gly Phe Val Ile Asn  Ser Met Asn Tyr Pro  Tyr Glu Val 
    1025                 1030                 1035             


Asp Gly  Lys Leu Ile Trp Asn  Pro Asp Leu Ile Asn  Glu Ile Lys 
    1040                 1045                 1050             


Lys Cys  Phe Tyr Tyr Lys Asp  Cys Tyr Cys Thr Thr  Lys Leu Asp 
    1055                 1060                 1065             


Gln Lys  Ser Gly Gln Leu Phe  Asn Leu Thr Val Leu  Ser Asn Asp 
    1070                 1075                 1080             


Ala His  Ala Asp Lys Gly Val  Thr Lys Ala Val Val  Pro Val Asn 
    1085                 1090                 1095             


Lys Asn  Arg Ser Asp Val His  Lys Tyr Gly Gly Phe  Ser Gly Leu 
    1100                 1105                 1110             


Gln Tyr  Thr Ile Val Ala Ile  Glu Gly Gln Lys Lys  Lys Gly Lys 
    1115                 1120                 1125             


Lys Thr  Glu Leu Val Lys Lys  Ile Ser Gly Val Pro  Leu His Leu 
    1130                 1135                 1140             


Lys Ala  Ala Ser Ile Asn Glu  Lys Ile Asn Tyr Ile  Glu Glu Lys 
    1145                 1150                 1155             


Glu Gly  Leu Ser Asp Val Arg  Ile Ile Lys Asp Asn  Ile Pro Val 
    1160                 1165                 1170             


Asn Gln  Met Ile Glu Met Asp  Gly Gly Glu Tyr Leu  Leu Thr Ser 
    1175                 1180                 1185             


Pro Thr  Glu Tyr Val Asn Ala  Arg Gln Leu Val Leu  Asn Glu Lys 
    1190                 1195                 1200             


Gln Cys  Ala Leu Ile Ala Asp  Ile Tyr Asn Ala Ile  Tyr Lys Gln 
    1205                 1210                 1215             


Asp Tyr  Asp Asn Leu Asp Asp  Ile Leu Met Ile Gln  Leu Tyr Ile 
    1220                 1225                 1230             


Glu Leu  Thr Asn Lys Met Lys  Val Leu Tyr Pro Ala  Tyr Arg Gly 
    1235                 1240                 1245             


Ile Ala  Glu Lys Phe Glu Ser  Met Asn Glu Asn Tyr  Val Val Ile 
    1250                 1255                 1260             


Ser Lys  Glu Glu Lys Ala Asn  Ile Ile Lys Gln Met  Leu Ile Val 
    1265                 1270                 1275             


Met His  Arg Gly Pro Gln Asn  Gly Asn Ile Val Tyr  Asp Asp Phe 
    1280                 1285                 1290             


Lys Ile  Ser Asp Arg Ile Gly  Arg Leu Lys Thr Lys  Asn His Asn 
    1295                 1300                 1305             


Leu Asn  Asn Ile Val Phe Ile  Ser Gln Ser Pro Thr  Gly Ile Tyr 
    1310                 1315                 1320             


Thr Lys  Lys Tyr Lys Leu 
    1325                 


<210> 163
<211> 1419
<212> PRT
<213> Chryseobacterium sp.


<220>
<223> Chryseobacterium sp. CF314

<400> 163
Met Met Ile Lys Asn Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile 
1               5                   10                  15      


Gly Trp Ala Leu Ile Lys Gln Asn Phe Glu Asn Lys Tyr Gly Glu Ile 
            20                  25                  30          


Leu Gly Met Gly Ser Arg Ile Ile Pro Met Ser Gln Asp Val Leu Gly 
        35                  40                  45              


Glu Phe Gly Lys Gly Asn Ser Val Ser Gln Thr Ala Ala Arg Thr Gly 
    50                  55                  60                  


Tyr Arg Gly Val Arg Arg Leu Arg Glu Arg Phe Leu Leu Arg Arg Glu 
65                  70                  75                  80  


Arg Leu His Arg Val Leu Asn Val Leu Asn Phe Leu Pro Glu His Tyr 
                85                  90                  95      


Ala Ser Gln Ile Asp Phe Glu Lys Arg Phe Gly Lys Phe Lys Tyr Glu 
            100                 105                 110         


Thr Glu Pro Lys Leu Ala Tyr Asn Asn Asp Gly Phe Phe Phe Lys Asn 
        115                 120                 125             


Ser Phe Asp Glu Met Leu Gly Asp Phe Lys Asp His Gln Phe His Leu 
    130                 135                 140                 


Leu Glu Asn Gly Arg Lys Val Pro Tyr Asp Trp Thr Ile Tyr Tyr Leu 
145                 150                 155                 160 


Arg Lys Lys Ala Leu Ser Gln Lys Ile Glu Lys Glu Glu Leu Ala Trp 
                165                 170                 175     


Ile Leu Leu Asn Phe Asn Gln Lys Arg Gly Tyr Tyr Gln Leu Arg Gly 
            180                 185                 190         


Glu Asp Phe Glu Glu Glu Lys Asp Arg Val Phe Val Arg Leu Lys Val 
        195                 200                 205             


Asp Arg Val Val Asp Ser Gly Glu Asn Ile Lys Gly Lys Ile Leu Tyr 
    210                 215                 220                 


Asp Val Tyr Phe Glu Asn Gly Trp Lys Tyr Glu Lys Gln Ile Val Lys 
225                 230                 235                 240 


Thr Glu Asp Trp Ile Gly Arg Thr Lys Glu Phe Ile Val Thr Glu Ser 
                245                 250                 255     


Ile Leu Lys Asn Gly Asp Thr Lys Arg Thr Phe Lys Ala Val Asp Ser 
            260                 265                 270         


Glu Lys Asp Trp Ile Ala Ile Lys Thr Lys Thr Glu Gln Glu Ile Asp 
        275                 280                 285             


Lys Ser His Lys Thr Val Gly Ala Tyr Ile Tyr Glu Ala Leu Leu Gln 
    290                 295                 300                 


Asn Pro Lys Gln Lys Ile Lys Gly Lys Leu Val Arg Thr Ile Glu Arg 
305                 310                 315                 320 


Lys Phe Tyr Arg Glu Glu Leu Lys Lys Ile Leu Glu Arg Gln Lys Glu 
                325                 330                 335     


Phe His Pro Glu Leu Gln Ser Asp Asp Leu Tyr Asn Asp Cys Ile Arg 
            340                 345                 350         


Glu Leu Tyr Arg Asn Asn Glu Ala His Gln Ile Thr Leu Ser Lys Lys 
        355                 360                 365             


Asp Phe Val His Leu Leu Leu Asn Asp Leu Ile Phe Tyr Gln Arg Pro 
    370                 375                 380                 


Leu Arg Ser Gln Lys Ser Ser Val Ser Asn Cys Thr Leu Glu Phe Arg 
385                 390                 395                 400 


Lys Tyr Lys Asp Glu Asn Gly Val Glu His Ala Gln Tyr Leu Lys Thr 
                405                 410                 415     


Ile Pro Lys Ser Asn Pro Tyr Tyr Gln Glu Phe Arg Val Trp Gln Trp 
            420                 425                 430         


Met Phe Asn Leu Asn Ile Tyr Arg Lys Asp Asp Asp Thr Asn Val Thr 
        435                 440                 445             


Lys Glu Phe Leu Ser Ser Thr Glu Asp Tyr Glu Thr Leu Phe Glu Phe 
    450                 455                 460                 


Leu Asn Asn Arg Lys Glu Val Asp Gln Lys Ala Leu Leu Arg His Phe 
465                 470                 475                 480 


Lys Leu Asn Glu Lys Thr His Arg Trp Asn Tyr Val Glu Asp Lys Lys 
                485                 490                 495     


Tyr Pro Cys Asn Glu Thr Lys Thr Met Ile Ser Thr Arg Leu Glu Lys 
            500                 505                 510         


Val Glu Asn Tyr Pro Ser Asp Phe Leu Thr Arg Glu Met Glu Gln Asn 
        515                 520                 525             


Ile Trp His Ile Ile Tyr Ser Val Asn Asp Lys Ile Glu Tyr Glu Lys 
    530                 535                 540                 


Ala Leu Lys Ser Phe Ala His Lys Asn Asn Leu Asp Glu Asn Ser Phe 
545                 550                 555                 560 


Phe Glu Ala Phe Lys Lys Phe Pro Pro Phe Lys Ser Glu Tyr Gly Ser 
                565                 570                 575     


Phe Ser Glu Lys Ala Ile Lys Lys Leu Leu Pro Leu Leu Arg Leu Gly 
            580                 585                 590         


Lys Tyr Trp Asn Trp Glu Ser Ile Asp Arg Lys Ser Gln Gly Arg Ile 
        595                 600                 605             


Glu Lys Ile Ile Thr Gly Glu Phe Asp Gly Asn Ile Lys Asp Lys Val 
    610                 615                 620                 


Arg Glu Lys Ala Ile His Leu Thr Ala Glu Asn Asp Phe Gln Gly Leu 
625                 630                 635                 640 


Gln Leu Trp Leu Ala Gln Tyr Ile Val Tyr Gly Arg His Ser Glu Ala 
                645                 650                 655     


Ser Met Ile Gly Lys Trp Asn Ser Ala Asp Asp Leu Glu Glu Phe Leu 
            660                 665                 670         


Lys Gly Phe Lys Gln His Ser Leu Arg Asn Pro Ile Val Glu Gln Val 
        675                 680                 685             


Ile Thr Glu Thr Leu Arg Val Val Lys Asp Ile Trp Leu Lys Tyr Gly 
    690                 695                 700                 


Asn Gly Ala Lys Asp Phe Phe Ser Glu Ile His Ile Glu Leu Gly Arg 
705                 710                 715                 720 


Glu Met Lys Gln Thr Lys Asp Glu Arg Val Asp Ala Thr Lys Arg Ile 
                725                 730                 735     


Thr Glu Asn Glu Asn Thr Asn Leu Arg Ile Lys Ala Leu Leu Ala Glu 
            740                 745                 750         


Met Met Asn Asp Asn Ser Val Glu Asn Ile Arg Pro Tyr Ser Pro Met 
        755                 760                 765             


Gln Gln Glu Ile Leu Lys Ile Tyr Glu Asp Gly Ile Leu Lys Ser Asp 
    770                 775                 780                 


Ile Glu Ile Asp Asp Asp Ile Leu Lys Ile Ser Lys Thr Ala Gln Pro 
785                 790                 795                 800 


Ser Ser Ser Asp Leu Lys Arg Tyr Lys Leu Trp Leu Glu Gln Arg Tyr 
                805                 810                 815     


Lys Ser Pro Tyr Thr Gly Gln Ile Ile Pro Leu Asn Lys Leu Phe Thr 
            820                 825                 830         


Ser Glu Tyr Glu Ile Glu His Ile Ile Pro Gln Ser Arg Tyr Phe Asp 
        835                 840                 845             


Asp Ser Phe Ser Asn Lys Ile Ile Cys Glu Ser Ala Val Asn Lys Leu 
    850                 855                 860                 


Lys Asp Asn Tyr Ile Gly Leu Gly Phe Ile Lys Gln Phe Gly Gly Met 
865                 870                 875                 880 


Ile Val Glu Cys Gly Phe Gly Lys Ser Val Glu Ile Phe Lys Ala Glu 
                885                 890                 895     


Glu Tyr Glu Asp Phe Val Lys Lys His Tyr Ala Asn Asn Arg Ser Lys 
            900                 905                 910         


Arg Asn Lys Leu Leu Leu Glu Glu Ile Pro Glu Lys Met Ile Asp Arg 
        915                 920                 925             


Gln Leu Asn Asp Thr Arg His Ile Ser Lys Tyr Ile Ser Gly Val Leu 
    930                 935                 940                 


Ser Asn Ile Val Arg Gln Glu Asp Gly Thr Asp Glu Gly Val Asn Ser 
945                 950                 955                 960 


Lys Asn Ile Val Pro Gly Asn Gly Lys Ile Thr Thr Gln Leu Lys Gln 
                965                 970                 975     


Asp Trp Gly Leu Asn Asp Val Trp Asn Glu Leu Ile Leu Pro Arg Phe 
            980                 985                 990         


Glu Arg Met Asn Gln Leu Thr Asn  Ser Thr Asp Phe Thr  Ser Trp Asn 
        995                 1000                 1005             


Lys Asn  His Gln Lys Phe Leu  Pro Thr Val Pro Ile  Glu Phe Ser 
    1010                 1015                 1020             


Lys Gly  Phe Ser Lys Lys Arg  Ile Asp His Arg His  His Ala Met 
    1025                 1030                 1035             


Asp Ala  Leu Val Ile Ala Cys  Ala Thr Lys Asp His  Ile Asn Leu 
    1040                 1045                 1050             


Leu Asn  Asn Gln Ser Ala Lys  Ser Asp Thr Lys Arg  Tyr Asp Leu 
    1055                 1060                 1065             


Lys Arg  Lys Leu Met Lys Phe  Glu Arg Val Val Tyr  Ser His Ser 
    1070                 1075                 1080             


Lys Thr  Gly Glu Lys Ile Glu  Lys Glu Val Pro Lys  Gln Phe Leu 
    1085                 1090                 1095             


Lys Pro  Trp Asp Asn Phe Thr  Val Asp Ala Lys Asn  Lys Met Glu 
    1100                 1105                 1110             


Thr Ile  Ile Val Ser Phe Lys  Gln Asn Leu Arg Val  Ile Asn Lys 
    1115                 1120                 1125             


Ala Thr  Asn His Tyr Glu Lys  Trp Ile Glu Lys Asp  Gly Ile Lys 
    1130                 1135                 1140             


Arg Lys  Glu Leu Ile Lys Gln  Glu Gly Thr Asn Trp  Ala Ile Arg 
    1145                 1150                 1155             


Lys Pro  Met His Lys Glu Thr  Val Ser Gly Lys Val  Asp Leu Pro 
    1160                 1165                 1170             


Gly Ile  Lys Ile Pro Lys Gly  Lys Ile Leu Thr Ala  Thr Arg Lys 
    1175                 1180                 1185             


Ser Leu  Asp Thr Ser Phe Asp  Leu Lys Thr Ile Asn  Ser Ile Thr 
    1190                 1195                 1200             


Asp Thr  Gly Ile Gln Lys Ile  Leu Lys Asn Tyr Leu  Glu Phe Lys 
    1205                 1210                 1215             


Gly Ser  Ser Glu Leu Ala Phe  Ser Pro Glu Gly Ile  Glu Asp Met 
    1220                 1225                 1230             


Asn Lys  Asn Ile Glu Lys Phe  Asn Asp Gly Lys Pro  His Gln Ser 
    1235                 1240                 1245             


Ile Asn  Lys Val Arg Ile Phe  Glu Leu Gly Ser Lys  Phe Ser Val 
    1250                 1255                 1260             


Gly Gln  Thr Gly Asn Lys Lys  Asp Lys Tyr Val Glu  Ala Ala Lys 
    1265                 1270                 1275             


Gly Thr  Asn Leu Phe Phe Ala  Val Tyr Glu Asp Lys  Asn Gly Lys 
    1280                 1285                 1290             


Arg Ser  Tyr Glu Thr Ile Pro  Leu Asn Glu Val Ile  Glu Arg Gln 
    1295                 1300                 1305             


Lys Gln  Gly Leu Asp Ser Val  Ser Phe Lys Asn Lys  Glu Asp Phe 
    1310                 1315                 1320             


Leu Leu  Cys Pro Asn Asp Leu  Val Tyr Val Pro Ser  Glu Asp Glu 
    1325                 1330                 1335             


Leu Glu  Asn Ile Tyr Asn Ile  Asp Phe Lys Asn Leu  Thr Thr Glu 
    1340                 1345                 1350             


Lys Thr  Gly Asn Ile Tyr Lys  Val Val Ser Phe Ser  Gly Asn Gln 
    1355                 1360                 1365             


Ile Phe  Phe Ile Arg Gln Asp  Ile Ala Ile Ser Ile  Val Asn Lys 
    1370                 1375                 1380             


Ala Glu  Phe Ser Thr Leu Asn  Lys Met Glu Arg Ala  Ile Asp Gly 
    1385                 1390                 1395             


Ser Met  Ile Lys Glu Asn Cys  Ile Lys Leu Lys Ile  Asp Arg Leu 
    1400                 1405                 1410             


Gly Asn  Ile Ala Lys Ile 
    1415                 


<210> 164
<211> 1021
<212> PRT
<213> Clostridium cellulolyticum

<400> 164
Met Lys Tyr Thr Leu Gly Leu Asp Val Gly Ile Ala Ser Val Gly Trp 
1               5                   10                  15      


Ala Val Ile Asp Lys Asp Asn Asn Lys Ile Ile Asp Leu Gly Val Arg 
            20                  25                  30          


Cys Phe Asp Lys Ala Glu Glu Ser Lys Thr Gly Glu Ser Leu Ala Thr 
        35                  40                  45              


Ala Arg Arg Ile Ala Arg Gly Met Arg Arg Arg Ile Ser Arg Arg Ser 
    50                  55                  60                  


Gln Arg Leu Arg Leu Val Lys Lys Leu Phe Val Gln Tyr Glu Ile Ile 
65                  70                  75                  80  


Lys Asp Ser Ser Glu Phe Asn Arg Ile Phe Asp Thr Ser Arg Asp Gly 
                85                  90                  95      


Trp Lys Asp Pro Trp Glu Leu Arg Tyr Asn Ala Leu Ser Arg Ile Leu 
            100                 105                 110         


Lys Pro Tyr Glu Leu Val Gln Val Leu Thr His Ile Thr Lys Arg Arg 
        115                 120                 125             


Gly Phe Lys Ser Asn Arg Lys Glu Asp Leu Ser Thr Thr Lys Glu Gly 
    130                 135                 140                 


Val Val Ile Thr Ser Ile Lys Asn Asn Ser Glu Met Leu Arg Thr Lys 
145                 150                 155                 160 


Asn Tyr Arg Thr Ile Gly Glu Met Ile Phe Met Glu Thr Pro Glu Asn 
                165                 170                 175     


Ser Asn Lys Arg Asn Lys Val Asp Glu Tyr Ile His Thr Ile Ala Arg 
            180                 185                 190         


Glu Asp Leu Leu Asn Glu Ile Lys Tyr Ile Phe Ser Ile Gln Arg Lys 
        195                 200                 205             


Leu Gly Ser Pro Phe Val Thr Glu Lys Leu Glu His Asp Phe Leu Asn 
    210                 215                 220                 


Ile Trp Glu Phe Gln Arg Pro Phe Ala Ser Gly Asp Ser Ile Leu Ser 
225                 230                 235                 240 


Lys Val Gly Lys Cys Thr Leu Leu Lys Glu Glu Leu Arg Ala Pro Thr 
                245                 250                 255     


Ser Cys Tyr Thr Ser Glu Tyr Phe Gly Leu Leu Gln Ser Ile Asn Asn 
            260                 265                 270         


Leu Val Leu Val Glu Asp Asn Asn Thr Leu Thr Leu Asn Asn Asp Gln 
        275                 280                 285             


Arg Ala Lys Ile Ile Glu Tyr Ala His Phe Lys Asn Glu Ile Lys Tyr 
    290                 295                 300                 


Ser Glu Ile Arg Lys Leu Leu Asp Ile Glu Pro Glu Ile Leu Phe Lys 
305                 310                 315                 320 


Ala His Asn Leu Thr His Lys Asn Pro Ser Gly Asn Asn Glu Ser Lys 
                325                 330                 335     


Lys Phe Tyr Glu Met Lys Ser Tyr His Lys Leu Lys Ser Thr Leu Pro 
            340                 345                 350         


Thr Asp Ile Trp Gly Lys Leu His Ser Asn Lys Glu Ser Leu Asp Asn 
        355                 360                 365             


Leu Phe Tyr Cys Leu Thr Val Tyr Lys Asn Asp Asn Glu Ile Lys Asp 
    370                 375                 380                 


Tyr Leu Gln Ala Asn Asn Leu Asp Tyr Leu Ile Glu Tyr Ile Ala Lys 
385                 390                 395                 400 


Leu Pro Thr Phe Asn Lys Phe Lys His Leu Ser Leu Val Ala Met Lys 
                405                 410                 415     


Arg Ile Ile Pro Phe Met Glu Lys Gly Tyr Lys Tyr Ser Asp Ala Cys 
            420                 425                 430         


Asn Met Ala Glu Leu Asp Phe Thr Gly Ser Ser Lys Leu Glu Lys Cys 
        435                 440                 445             


Asn Lys Leu Thr Val Glu Pro Ile Ile Glu Asn Val Thr Asn Pro Val 
    450                 455                 460                 


Val Ile Arg Ala Leu Thr Gln Ala Arg Lys Val Ile Asn Ala Ile Ile 
465                 470                 475                 480 


Gln Lys Tyr Gly Leu Pro Tyr Met Val Asn Ile Glu Leu Ala Arg Glu 
                485                 490                 495     


Ala Gly Met Thr Arg Gln Asp Arg Asp Asn Leu Lys Lys Glu His Glu 
            500                 505                 510         


Asn Asn Arg Lys Ala Arg Glu Lys Ile Ser Asp Leu Ile Arg Gln Asn 
        515                 520                 525             


Gly Arg Val Ala Ser Gly Leu Asp Ile Leu Lys Trp Arg Leu Trp Glu 
    530                 535                 540                 


Asp Gln Gly Gly Arg Cys Ala Tyr Ser Gly Lys Pro Ile Pro Val Cys 
545                 550                 555                 560 


Asp Leu Leu Asn Asp Ser Leu Thr Gln Ile Asp His Ile Tyr Pro Tyr 
                565                 570                 575     


Ser Arg Ser Met Asp Asp Ser Tyr Met Asn Lys Val Leu Val Leu Thr 
            580                 585                 590         


Asp Glu Asn Gln Asn Lys Arg Ser Tyr Thr Pro Tyr Glu Val Trp Gly 
        595                 600                 605             


Ser Thr Glu Lys Trp Glu Asp Phe Glu Ala Arg Ile Tyr Ser Met His 
    610                 615                 620                 


Leu Pro Gln Ser Lys Glu Lys Arg Leu Leu Asn Arg Asn Phe Ile Thr 
625                 630                 635                 640 


Lys Asp Leu Asp Ser Phe Ile Ser Arg Asn Leu Asn Asp Thr Arg Tyr 
                645                 650                 655     


Ile Ser Arg Phe Leu Lys Asn Tyr Ile Glu Ser Tyr Leu Gln Phe Ser 
            660                 665                 670         


Asn Asp Ser Pro Lys Ser Cys Val Val Cys Val Asn Gly Gln Cys Thr 
        675                 680                 685             


Ala Gln Leu Arg Ser Arg Trp Gly Leu Asn Lys Asn Arg Glu Glu Ser 
    690                 695                 700                 


Asp Leu His His Ala Leu Asp Ala Ala Val Ile Ala Cys Ala Asp Arg 
705                 710                 715                 720 


Lys Ile Ile Lys Glu Ile Thr Asn Tyr Tyr Asn Glu Arg Glu Asn His 
                725                 730                 735     


Asn Tyr Lys Val Lys Tyr Pro Leu Pro Trp His Ser Phe Arg Gln Asp 
            740                 745                 750         


Leu Met Glu Thr Leu Ala Gly Val Phe Ile Ser Arg Ala Pro Arg Arg 
        755                 760                 765             


Lys Ile Thr Gly Pro Ala His Asp Glu Thr Ile Arg Ser Pro Lys His 
    770                 775                 780                 


Phe Asn Lys Gly Leu Thr Ser Val Lys Ile Pro Leu Thr Thr Val Thr 
785                 790                 795                 800 


Leu Glu Lys Leu Glu Thr Met Val Lys Asn Thr Lys Gly Gly Ile Ser 
                805                 810                 815     


Asp Lys Ala Val Tyr Asn Val Leu Lys Asn Arg Leu Ile Glu His Asn 
            820                 825                 830         


Asn Lys Pro Leu Lys Ala Phe Ala Glu Lys Ile Tyr Lys Pro Leu Lys 
        835                 840                 845             


Asn Gly Thr Asn Gly Ala Ile Ile Arg Ser Ile Arg Val Glu Thr Pro 
    850                 855                 860                 


Ser Tyr Thr Gly Val Phe Arg Asn Glu Gly Lys Gly Ile Ser Asp Asn 
865                 870                 875                 880 


Ser Leu Met Val Arg Val Asp Val Phe Lys Lys Lys Asp Lys Tyr Tyr 
                885                 890                 895     


Leu Val Pro Ile Tyr Val Ala His Met Ile Lys Lys Glu Leu Pro Ser 
            900                 905                 910         


Lys Ala Ile Val Pro Leu Lys Pro Glu Ser Gln Trp Glu Leu Ile Asp 
        915                 920                 925             


Ser Thr His Glu Phe Leu Phe Ser Leu Tyr Gln Asn Asp Tyr Leu Val 
    930                 935                 940                 


Ile Lys Thr Lys Lys Gly Ile Thr Glu Gly Tyr Tyr Arg Ser Cys His 
945                 950                 955                 960 


Arg Gly Thr Gly Ser Leu Ser Leu Met Pro His Phe Ala Asn Asn Lys 
                965                 970                 975     


Asn Val Lys Ile Asp Ile Gly Val Arg Thr Ala Ile Ser Ile Glu Lys 
            980                 985                 990         


Tyr Asn Val Asp Ile Leu Gly Asn  Lys Ser Ile Val Lys  Gly Glu Pro 
        995                 1000                 1005             


Arg Arg  Gly Met Glu Lys Tyr  Asn Ser Phe Lys Ser  Asn 
    1010                 1015                 1020     


<210> 165
<211> 1065
<212> PRT
<213> Clostridium perfringens


<220>
<223> Clostridium perfringens C str. JGS1495

<400> 165
Met Asn Lys Asp Ile Asn Tyr Ala Leu Gly Leu Asp Ile Gly Ile Thr 
1               5                   10                  15      


Ser Val Gly Trp Ala Val Ile Asn Leu Asp Leu Asn Arg Ile Glu Asp 
            20                  25                  30          


Leu Gly Val Arg Ile Phe Asn Ala Ala Glu Asn Pro Lys Asp Gly Ser 
        35                  40                  45              


Ser Leu Ala Leu Pro Arg Arg Leu Ala Arg Gly Arg Arg Arg Leu Leu 
    50                  55                  60                  


Arg Arg Lys Ala Tyr Arg Val Glu Arg Val Arg Lys Leu Ile Val Lys 
65                  70                  75                  80  


Asn Asn Ile Leu Thr Lys Glu Glu Leu Glu Gly Leu Phe Lys Asn Lys 
                85                  90                  95      


Glu Val Ile Asp Val Trp Glu Ala Arg Val Lys Gly Leu Asp Tyr Lys 
            100                 105                 110         


Leu Ser Arg Glu Glu Trp Ala Lys Ile Leu Ile Asn Phe Cys Lys Arg 
        115                 120                 125             


Arg Gly Phe Lys Ser Asn Arg Lys Asn Glu Thr Lys Asp Lys Glu Ala 
    130                 135                 140                 


Gly Gln Ile Leu Ser Ser Ile Ser Tyr Asn Ile Glu Lys Met Lys Glu 
145                 150                 155                 160 


Thr Asn Ser Arg Thr Ile Gly Glu Tyr Ile Tyr Asn Glu Val Lys Asn 
                165                 170                 175     


Ser Asp Asp Ser Tyr Ala Pro Leu Arg Asn Lys Phe Gly Glu Tyr Lys 
            180                 185                 190         


Met Cys Val Ser Arg Asp Val Leu Arg Glu Glu Ile His Thr Leu Phe 
        195                 200                 205             


Glu Lys Gln Arg Glu Leu Gly Asn Asn Phe Ala Ser Asp Glu Ile Glu 
    210                 215                 220                 


Asp Lys Tyr Phe Glu Ile Phe Asn Ser Gln Arg Pro Phe Ser Asn Phe 
225                 230                 235                 240 


Glu Asp Leu Glu Lys Leu Val Gly Phe Cys Thr Phe Glu Arg Lys Lys 
                245                 250                 255     


His Lys Arg Ala Pro Lys His Cys Ile Ser Ser Glu Glu Phe Thr Leu 
            260                 265                 270         


Tyr Glu Gly Ile Asn Lys Leu Ser Ile Ile Lys Asp Gly Glu Lys Arg 
        275                 280                 285             


Lys Leu Ser Glu Glu Glu Arg Thr Leu Val Val Asn Glu Ala Phe Asn 
    290                 295                 300                 


Lys Lys Glu Ile Lys Tyr Thr Thr Leu Arg Lys Leu Leu Gly Leu Ser 
305                 310                 315                 320 


Glu Asp Glu Leu Phe Ser Thr Leu Thr Tyr Ser Ile Asp Lys Asp Ile 
                325                 330                 335     


Ser Lys Thr Glu Asn Thr Lys Phe Val Ser Leu Lys Gly Tyr His Glu 
            340                 345                 350         


Ile Lys Arg Ala Ile Glu Lys Gly Val Ser Lys Lys Ala Trp Gln Asp 
        355                 360                 365             


Ile Glu Asn Asn Arg Asn Leu Leu Asn Asp Ile Ala Tyr Val Leu Thr 
    370                 375                 380                 


Leu Gly Lys Thr Asp Asp Glu Ile Glu Lys Gln Leu Arg Leu Arg Asn 
385                 390                 395                 400 


Val Pro Glu Glu Leu Phe Glu Ser Leu Leu Asp Met Ser Phe Ser Lys 
                405                 410                 415     


Phe Asn Asn Leu Ser Ile Tyr Ala Leu Glu Lys Ile Leu Pro Phe Met 
            420                 425                 430         


Lys Glu Gly Tyr Gln Tyr Asn Glu Ala Cys Glu Lys Ala Gly Tyr Asn 
        435                 440                 445             


Phe Lys Ala Ile Tyr Glu Gly Val Arg Thr Lys Lys Leu Pro Val Ile 
    450                 455                 460                 


Glu Ile Asp Glu Ile Val Asn Pro Val Val Asn Arg Ala Leu Ala Gln 
465                 470                 475                 480 


Thr Arg Lys Val Ile Asn Ser Val Ile Asp Lys Tyr Gly Ser Pro Val 
                485                 490                 495     


Arg Ile Asn Ile Glu Leu Ala Arg Asp Leu Ala Lys Asn Phe Lys Asp 
            500                 505                 510         


Arg Lys Leu Ile Glu Lys Glu Gln Lys Glu Asn Arg Ala Asn Leu Asp 
        515                 520                 525             


Lys Ile Arg Glu Asn Leu Arg Glu Leu Met Asp Lys Glu Pro Thr Ala 
    530                 535                 540                 


Val Glu Val Leu Lys Tyr Arg Leu Trp Glu Gln Gln Arg Gly Glu Cys 
545                 550                 555                 560 


Ala Tyr Thr Gln Ser Gln Ile Ala Leu Glu Arg Leu Phe Ser Pro Gly 
                565                 570                 575     


Tyr Cys Glu Ile Asp His Ile Ile Pro Phe Ser Arg Ser Phe Asp Asp 
            580                 585                 590         


Ser Leu Ser Asn Lys Ile Leu Val Leu Gly Ser Glu Asn Gln Arg Lys 
        595                 600                 605             


Gly Asn Lys Ile Pro Tyr Glu Tyr Phe Gly Glu Asp Ser Glu Arg Trp 
    610                 615                 620                 


Asn Ser Phe Glu Ile Trp Val Lys Gly Ser Tyr Leu Asn Tyr Lys Lys 
625                 630                 635                 640 


Lys Ala Asn Leu Leu Lys Lys Lys Phe Thr Glu Glu Glu Gln Arg Asp 
                645                 650                 655     


Trp Lys Ala Arg Asn Leu Gln Asp Thr Lys Tyr Ile Cys Arg Tyr Ile 
            660                 665                 670         


Ser Asn Phe Val Asn Asn Arg Leu Glu Phe Lys Glu Ser Glu Asn Lys 
        675                 680                 685             


Gln Lys Val Ile Thr Val Asn Gly Arg Ala Thr Ala Tyr Leu Arg Ser 
    690                 695                 700                 


Arg Trp Gly Leu Asn Lys Val Arg Glu Asp Gly Asp Lys His His Ala 
705                 710                 715                 720 


Leu Asp Ala Ala Val Val Gly Val Thr Thr Gln Gly Met Val Gln Lys 
                725                 730                 735     


Ile Ser Lys Tyr Ser Lys Ala His Glu Leu Tyr Thr Val Arg Lys Asn 
            740                 745                 750         


Asp Glu Phe Val Asp Val Glu Thr Gly Glu Cys Val Asp Val Asp Glu 
        755                 760                 765             


Tyr Lys Glu Ile Arg Lys Asp Ile Leu Pro Arg Pro Trp Arg Gly Phe 
    770                 775                 780                 


Ser Glu Glu Leu Lys Leu Arg Leu Ser Asp Asn Pro Leu Glu Glu Leu 
785                 790                 795                 800 


Lys Lys Leu Pro Ile Glu Thr Tyr Asn Glu Glu Phe Ile Lys Glu Asn 
                805                 810                 815     


Val Lys Pro Ile Phe Val Ser Arg Val Pro Phe Arg Lys Ile Ser Gly 
            820                 825                 830         


Lys Leu Phe Lys Glu Thr Ile Tyr Ser Glu Arg Ala Phe Lys Asp Gly 
        835                 840                 845             


Tyr Phe Val Ser Lys Lys Ser Leu Val Asp Leu Lys Arg Gly Asp Leu 
    850                 855                 860                 


Asp Asn Phe Tyr Asn Tyr Glu Cys Asp Lys Lys Leu Tyr Asp Ala Ile 
865                 870                 875                 880 


Ser Glu Arg Met Lys Glu Phe Asn Tyr Asn Gly Lys Lys Ala Phe Glu 
                885                 890                 895     


Ser Pro Phe Arg Lys Pro Thr Lys Ser Gly Lys Glu Gly Pro Val Val 
            900                 905                 910         


Arg Ser Val Lys Ile Lys Ser Ala Ala Pro Phe Lys Asp Gly Ile Pro 
        915                 920                 925             


Met Asn Glu Gly Leu Val Ala Lys Glu Gly Met Val Arg Ile Asp Ile 
    930                 935                 940                 


Tyr Glu Lys Glu Gly Lys Tyr Phe Val Val Pro Val Tyr Arg Tyr Gln 
945                 950                 955                 960 


Leu Ala Lys Gly Ile Val Pro Lys Arg Ala Ala Ile Ala Gly Lys Ser 
                965                 970                 975     


Glu Leu Lys Trp Pro Ile Met Asp Gln Thr Tyr Asn Phe Lys Phe Ser 
            980                 985                 990         


Ile Phe Lys Asn Asp Leu Ile Glu  Ile Lys Tyr Ala Lys  Lys Asp Gly 
        995                 1000                 1005             


Tyr Phe  Gly Tyr Tyr Asp Gly  Phe Asp Arg His Thr  Ala Ser Leu 
    1010                 1015                 1020             


Val Ile  Glu Asn His Asp Asn  Ser Asp Arg Tyr Arg  Gly Ile Gly 
    1025                 1030                 1035             


Val Lys  Thr Gly Val Val Glu  Phe Asn Lys Tyr Glu  Val Asp Val 
    1040                 1045                 1050             


Leu Gly  Asn Tyr His Lys Val  Asn Leu Gly Gly Asn  
    1055                 1060                 1065 


<210> 166
<211> 1065
<212> PRT
<213> Clostridium perfringens


<220>
<223> Clostridium perfringens D str. JGS1721

<400> 166
Met Asn Lys Asp Ile Asn Tyr Ala Leu Gly Leu Asp Ile Gly Ile Thr 
1               5                   10                  15      


Ser Val Gly Trp Ala Val Ile Asn Leu Asp Leu Asn Arg Ile Glu Asp 
            20                  25                  30          


Leu Gly Val Arg Ile Phe Asn Ala Ala Glu Asn Leu Lys Asp Gly Ser 
        35                  40                  45              


Ser Leu Ala Leu Pro Arg Arg Leu Ala Arg Gly Arg Arg Arg Leu Leu 
    50                  55                  60                  


Arg Arg Lys Ala Tyr Arg Val Glu Arg Val Arg Lys Leu Ile Leu Lys 
65                  70                  75                  80  


Asn Asn Ile Leu Thr Lys Glu Glu Leu Glu Gly Leu Phe Lys Asn Lys 
                85                  90                  95      


Glu Val Ile Asp Val Trp Glu Ala Arg Val Lys Gly Leu Asp Tyr Lys 
            100                 105                 110         


Leu Ser Arg Glu Glu Trp Ala Lys Ile Leu Ile Asn Phe Cys Lys Arg 
        115                 120                 125             


Arg Gly Phe Lys Ser Asn Arg Lys Asn Glu Ala Lys Asp Lys Glu Ala 
    130                 135                 140                 


Gly Gln Ile Leu Ser Ser Ile Ser Tyr Asn Ile Glu Lys Met Lys Glu 
145                 150                 155                 160 


Thr Asn Ser Arg Thr Ile Gly Glu Tyr Ile Tyr Asn Glu Val Lys Asn 
                165                 170                 175     


Ser Glu Asp Ser Tyr Ala Pro Leu Arg Asn Lys Phe Gly Glu Tyr Lys 
            180                 185                 190         


Met Cys Val Ser Arg Asp Val Ile Arg Glu Glu Ile His Thr Leu Phe 
        195                 200                 205             


Glu Lys Gln Arg Glu Leu Gly Asn Asn Phe Ala Ser Asp Glu Ile Glu 
    210                 215                 220                 


Asp Lys Tyr Phe Glu Ile Phe Asn Ser Gln Arg Pro Phe Ser Asn Phe 
225                 230                 235                 240 


Glu Asp Leu Glu Lys Leu Val Gly Phe Cys Thr Phe Glu Arg Lys Lys 
                245                 250                 255     


His Lys Arg Ala Pro Lys His Cys Ile Ser Ser Glu Glu Phe Thr Leu 
            260                 265                 270         


Tyr Glu Gly Ile Asn Lys Leu Ser Ile Ile Lys Asp Gly Glu Lys Arg 
        275                 280                 285             


Lys Leu Ser Glu Glu Glu Arg Thr Leu Val Val Asn Glu Ala Phe Asn 
    290                 295                 300                 


Lys Lys Glu Ile Lys Tyr Thr Thr Leu Arg Lys Leu Leu Gly Leu Ser 
305                 310                 315                 320 


Glu Glu Glu Leu Phe Ser Thr Leu Thr Tyr Ser Ile Asp Lys Asp Ile 
                325                 330                 335     


Ser Lys Thr Glu Asn Thr Lys Phe Val Ser Leu Lys Gly Tyr His Glu 
            340                 345                 350         


Ile Lys Arg Ala Ile Glu Lys Gly Val Ser Lys Lys Ala Trp Gln Asp 
        355                 360                 365             


Ile Glu Asn Asn Arg Asn Leu Leu Asn Asp Ile Ala Tyr Val Leu Thr 
    370                 375                 380                 


Leu Gly Lys Thr Asp Asp Glu Ile Glu Lys Gln Leu Arg Leu Arg Asn 
385                 390                 395                 400 


Val Pro Glu Glu Leu Phe Glu Ser Leu Leu Asp Met Ser Phe Asn Lys 
                405                 410                 415     


Phe Asn Asn Leu Ser Ile Tyr Ala Leu Glu Lys Ile Leu Pro Phe Met 
            420                 425                 430         


Lys Glu Gly Tyr Gln Tyr Asn Glu Ala Cys Glu Lys Ala Gly Tyr Asn 
        435                 440                 445             


Phe Lys Ala Ile Tyr Glu Gly Val Arg Thr Lys Lys Leu Pro Val Ile 
    450                 455                 460                 


Glu Ile Asp Glu Ile Val Asn Pro Val Val Asn Arg Ala Leu Ala Gln 
465                 470                 475                 480 


Thr Arg Lys Val Ile Asn Ser Val Ile Asp Lys Tyr Gly Ser Pro Val 
                485                 490                 495     


Arg Ile Asn Ile Glu Leu Ala Arg Asp Leu Ala Lys Asn Phe Lys Asp 
            500                 505                 510         


Arg Lys Leu Ile Glu Lys Glu Gln Lys Glu Asn Arg Ala Asn Leu Asp 
        515                 520                 525             


Lys Ile Arg Glu Asn Leu Arg Glu Leu Met Asp Lys Glu Pro Thr Val 
    530                 535                 540                 


Val Glu Val Leu Lys Tyr Arg Leu Trp Glu Gln Gln Arg Gly Glu Cys 
545                 550                 555                 560 


Ala Tyr Thr Gln Ser Gln Ile Pro Leu Glu Arg Leu Phe Ser Pro Gly 
                565                 570                 575     


Tyr Cys Glu Ile Asp His Ile Ile Pro Phe Ser Arg Ser Phe Asp Asp 
            580                 585                 590         


Ser Leu Ser Asn Lys Ile Leu Val Leu Gly Ser Glu Asn Gln Arg Lys 
        595                 600                 605             


Gly Asn Arg Thr Pro Tyr Glu Tyr Phe Gly Glu Asp Ser Glu Arg Trp 
    610                 615                 620                 


Asn Ser Phe Glu Ile Trp Val Lys Gly Ser Tyr Leu Asn Tyr Lys Lys 
625                 630                 635                 640 


Lys Ala Asn Leu Leu Lys Lys Lys Phe Ser Glu Glu Glu Gln Arg Asp 
                645                 650                 655     


Trp Lys Ala Arg Asn Leu Gln Asp Thr Lys Tyr Ile Cys Arg Tyr Ile 
            660                 665                 670         


Ser Asn Phe Val Asn Asn Arg Leu Glu Phe Lys Glu Ser Glu Asn Lys 
        675                 680                 685             


Gln Lys Val Ile Thr Val Asn Gly Arg Ala Thr Ala Tyr Leu Arg Ser 
    690                 695                 700                 


Arg Trp Gly Leu Asn Lys Val Arg Glu Asp Gly Asp Lys His His Ala 
705                 710                 715                 720 


Leu Asp Ala Ala Val Val Gly Val Thr Thr Gln Gly Met Val Gln Lys 
                725                 730                 735     


Ile Ser Lys Tyr Ser Lys Ala His Glu Leu Tyr Thr Val Arg Lys Asn 
            740                 745                 750         


Asp Glu Phe Val Asp Val Glu Thr Gly Glu Cys Val Asp Val Asp Glu 
        755                 760                 765             


Tyr Lys Glu Ile Arg Lys Asp Ile Leu Pro Arg Pro Trp Arg Gly Phe 
    770                 775                 780                 


Ser Glu Glu Leu Lys Leu Arg Leu Ser Asp Asn Pro Leu Glu Glu Leu 
785                 790                 795                 800 


Lys Lys Ser Pro Ile Glu Thr Tyr Asn Glu Glu Phe Ile Lys Glu Asn 
                805                 810                 815     


Val Lys Pro Ile Phe Val Ser Arg Val Pro Phe Arg Lys Ile Ser Gly 
            820                 825                 830         


Lys Leu Phe Lys Glu Thr Ile Tyr Ser Glu Arg Ala Phe Lys Asp Gly 
        835                 840                 845             


Tyr Phe Val Ser Lys Lys Ser Leu Val Asp Leu Lys Arg Gly Asp Leu 
    850                 855                 860                 


Asp Asn Phe Tyr Asn Tyr Glu Cys Asp Lys Lys Leu Tyr Asp Ala Ile 
865                 870                 875                 880 


Ser Glu Arg Met Lys Glu Phe Asn Tyr Asn Gly Lys Lys Ala Phe Glu 
                885                 890                 895     


Ser Pro Phe Arg Lys Pro Thr Lys Ser Gly Lys Glu Gly Pro Val Val 
            900                 905                 910         


Arg Ser Val Lys Ile Lys Ser Ala Val Pro Phe Lys Asp Gly Ile Pro 
        915                 920                 925             


Met Asn Glu Gly Leu Val Ala Lys Glu Gly Met Val Arg Ile Asp Ile 
    930                 935                 940                 


Tyr Glu Lys Glu Gly Lys Tyr Phe Val Val Pro Val Tyr Arg Tyr Gln 
945                 950                 955                 960 


Leu Ala Lys Gly Ile Val Pro Lys Arg Ala Ala Ile Ala Lys Lys Asp 
                965                 970                 975     


Glu Leu Lys Trp Pro Ile Met Asp Gln Thr Tyr Asn Phe Lys Phe Ser 
            980                 985                 990         


Ile Tyr Lys Asn Asp Leu Ile Glu  Val Lys Tyr Asp Lys  Lys Gly Val 
        995                 1000                 1005             


Tyr Phe  Gly Tyr Tyr Asp Gly  Phe Asp Arg Asn Ser  Ala Ser Leu 
    1010                 1015                 1020             


Thr Ile  Glu Lys His Asp Asn  Ser Glu Arg Tyr Arg  Ser Ile Gly 
    1025                 1030                 1035             


Leu Lys  Val Gly Val Leu Glu  Ile Asn Lys Tyr Glu  Val Asp Val 
    1040                 1045                 1050             


Leu Gly  Asn Tyr His Lys Val  Lys Leu Gly Gly Asn  
    1055                 1060                 1065 


<210> 167
<211> 1116
<212> PRT
<213> Clostridium spiroforme


<220>
<223> Clostridium spiroforme DSM 1552

<400> 167
Met Val Glu Phe Leu Leu Lys Glu Met Lys Ile Met Gly Arg Leu Val 
1               5                   10                  15      


Leu Gly Leu Asp Ile Gly Ile Thr Ser Val Gly Tyr Gly Val Ile Asp 
            20                  25                  30          


Ile Asp Lys Asn Glu Phe Val Asp Tyr Gly Val Arg Leu Phe Lys Glu 
        35                  40                  45              


Gly Thr Ala Ile Asn Asn Glu Glu Arg Arg Ser Lys Arg Gly Ala Arg 
    50                  55                  60                  


Arg Leu Lys Arg Arg Lys Thr Asn Arg Ile Ala Asp Met Lys Lys Leu 
65                  70                  75                  80  


Leu Glu Arg Asn Gly Leu Ile Asp Glu Gln Tyr Thr Ala Leu Asn Asn 
                85                  90                  95      


Pro Tyr Glu Ile Arg Lys Lys Gly Leu Lys Asn Lys Leu Ser Asn Tyr 
            100                 105                 110         


Glu Leu Ala Thr Ala Ile Leu His Ile Thr Lys Asn Arg Gly Thr Cys 
        115                 120                 125             


Leu Glu Ser Asn Ala Asp Glu Thr Gln Asp Glu Glu Ser Thr Lys Asn 
    130                 135                 140                 


Ile Leu Ser Lys Asn Ala Leu Glu Leu Lys Asp Lys Tyr Ile Cys Glu 
145                 150                 155                 160 


Ile Gln Leu Ala Arg Leu Glu Glu Ser Gly Lys Ile Arg Gly Ile Asn 
                165                 170                 175     


Asn Asn Phe Lys Thr Glu Asp Tyr Leu Lys Glu Leu Ser Lys Ile Leu 
            180                 185                 190         


Glu Asn Gln Asp Leu Glu Lys Glu Thr Ile Asp Lys Ile Lys Glu Ile 
        195                 200                 205             


Val Ala Arg Arg Arg Arg Tyr Asp Gln Gly Pro Gly Ser Glu Lys Ser 
    210                 215                 220                 


Pro Thr Pro Tyr Gly Ser Tyr Arg Met Glu Asn Gly Glu Leu Val His 
225                 230                 235                 240 


Val Asn Leu Ile Asp Met Met Arg Gly Lys Cys Ser Val Phe Pro Asp 
                245                 250                 255     


Gln Leu Arg Ala Pro Gln Gln Ser Tyr Ser Ala Glu Leu Phe Asn Leu 
            260                 265                 270         


Leu Asn Asp Leu Asn Asn Leu Lys Ile Asn Gly Glu Lys Leu Ser Ser 
        275                 280                 285             


Thr Glu Lys Gln Lys Ile Ile Asp Phe Val Asn Glu Lys Gly Gly Ile 
    290                 295                 300                 


Thr Val Lys Gln Leu Leu Lys Leu Ile Asp Val Gly Ile Thr Glu Ile 
305                 310                 315                 320 


Ser Gly Phe Arg Ile Asp Lys Asn Glu Lys Pro Leu Ile Thr Glu Phe 
                325                 330                 335     


Lys Gly Tyr Lys Lys Val Leu Lys Val Phe Lys Asn Tyr Asn Gln Glu 
            340                 345                 350         


Ser Leu Leu Asn Asp Lys Ser Ile Val Asp Thr Ile Met Asp Ile Asn 
        355                 360                 365             


Thr Lys Ile Lys Ser Ile Asp Glu Arg Ser Asp Gln Leu Lys Gln Val 
    370                 375                 380                 


Leu Pro Ser Leu Asp Thr Ser Ile Ile Asn Asp Leu Ala Ser Ile Lys 
385                 390                 395                 400 


Gly Val Ser Gly Tyr His Ser Leu Ser Leu Lys Ala Leu Asn Leu Ile 
                405                 410                 415     


Asn Asn Glu Met Leu Lys Thr Glu Met Asn Gln Met Gln Val Leu His 
            420                 425                 430         


Gln Leu Asp Ile Phe Asp Lys Asn Arg Val Ser Leu Lys Gly Gln Arg 
        435                 440                 445             


Gln Ile Tyr Ala Asp Asp Asn Ala Ile Leu Ser Pro Val Ala Lys Arg 
    450                 455                 460                 


Ala His Arg Glu Thr Phe Lys Val Ile Asn Lys Leu Arg Ser Ile Tyr 
465                 470                 475                 480 


Gly Glu Phe Asp Ser Ile Val Ile Glu Thr Thr Arg Asp Lys Asn Thr 
                485                 490                 495     


Gln Asp Gln Lys Lys Arg Ile Lys Asn Asn Gln Lys Asn Tyr Glu Glu 
            500                 505                 510         


Arg Asn Thr Glu Val Asn Asn Phe Leu Lys Glu Ala Gly Tyr Asn Pro 
        515                 520                 525             


Glu Asn Ile Asn Ala Lys Thr Lys Met Lys Ile Arg Leu Tyr Ile Glu 
    530                 535                 540                 


Gln Asp Ala Lys Ser Ala Tyr Thr Leu Gln Asp Ile Asn Leu Lys Glu 
545                 550                 555                 560 


Leu Ile Glu Asp Glu Lys Ala Tyr Glu Ile Asp His Ile Ile Pro Ile 
                565                 570                 575     


Ser Ile Ser Leu Asp Asp Ser Phe Asn Asn Lys Val Leu Thr Thr His 
            580                 585                 590         


Asp Glu Asn Gln Glu Lys Gly Asn Leu Thr Pro Ile Ser Ala Phe Leu 
        595                 600                 605             


Lys Gly Lys Phe His Asn Gly Asn Leu Asn Thr Tyr Lys Val Phe Ile 
    610                 615                 620                 


Gln Asn Asn Lys Asn Leu Asn Arg Lys Lys Lys Glu Tyr Leu Leu Cys 
625                 630                 635                 640 


Glu Asp Asp Ile Thr Arg Tyr Glu Val Val Gln Asn Phe Ile Asn Arg 
                645                 650                 655     


Asn Leu Val Asp Thr Ser Tyr Ala Cys Arg Thr Val Met Asn Thr Leu 
            660                 665                 670         


Val His Tyr Phe Lys Asp Asn Glu Ile Asn Thr Lys Val His Thr Ile 
        675                 680                 685             


Lys Gly Gln Ala Thr Ser Thr Phe Arg Lys Arg Ile Gly Leu Ile Lys 
    690                 695                 700                 


Asp Arg Glu Glu Asp Tyr Phe His His Ala Ile Asp Ala Leu Ile Val 
705                 710                 715                 720 


Ala Ser Leu Lys Lys Met Asn Leu Ile Asn Ser Tyr Leu Met Lys Val 
                725                 730                 735     


Asp Phe Asn Glu Met Tyr Asp Glu Glu Thr Gly Glu Ile Phe Asn Val 
            740                 745                 750         


Leu Pro Asp Asn Ser Tyr Leu Asp Glu Lys Tyr Ile Ser Phe Val Ser 
        755                 760                 765             


Asn Leu Lys Asn Ile Tyr Glu Glu Ser Asn Lys Tyr Ile Arg Gly Val 
    770                 775                 780                 


Met Ile Lys Glu Lys Met Thr Tyr Pro Leu Ile Lys Val Ser His Lys 
785                 790                 795                 800 


Ile Asp Thr Lys Pro Asn Arg Lys Ile Ser Asp Asp Thr Ile Tyr Ser 
                805                 810                 815     


Thr Arg Asn Val Asp Asn Gln Asp Met Leu Val Glu Arg Ile Lys Asn 
            820                 825                 830         


Ile Tyr Asp Pro Lys Glu Asn Ala Ala Asn Thr Leu Ile Asn Asp Ile 
        835                 840                 845             


Ile Asn Asp Asn Thr Asp Lys Tyr Ile Met Tyr His Lys Asp Pro Gln 
    850                 855                 860                 


Thr Phe Asp Lys Ile Lys Ala Ile Val Leu Asn His Phe Asn Glu Phe 
865                 870                 875                 880 


Lys Thr Asp Lys Asn Cys Tyr Ile Val Thr Lys Glu Gly Leu Tyr Lys 
                885                 890                 895     


Leu Lys Gly Thr Ser Pro Leu Ala Leu Tyr Tyr Glu Glu Phe Gly Pro 
            900                 905                 910         


Ile Thr Lys Tyr Ala Lys Lys Asn Asn Gly Pro Thr Ile His Ser Met 
        915                 920                 925             


Lys Phe Tyr Ser Glu Lys Leu Gly Asn His Leu Ser Ile Thr His Lys 
    930                 935                 940                 


Tyr Ser Thr Val Asn Lys Lys Val Ile Thr Lys Gln Ile Ser Pro Tyr 
945                 950                 955                 960 


Arg Thr Asp Phe Tyr Gln Ser Pro Glu Gly Lys Tyr Lys Phe Val Thr 
                965                 970                 975     


Val Arg Tyr Lys Asp Val Ala Tyr Asn Ala Lys Lys Asp Lys Tyr Ile 
            980                 985                 990         


Ile Asp His Ser Trp Tyr Arg Glu  Gln Lys Lys Leu Lys  Lys Ile Ala 
        995                 1000                 1005             


Asp Glu  Trp Ile Phe Val Cys  Ser Val His Arg Asp  Glu Leu Ile 
    1010                 1015                 1020             


Gly Ile  Met Lys Ala Asp Gly  Gln Lys Arg Ile Phe  Asp Ser Ser 
    1025                 1030                 1035             


Thr Glu  Ser Asp Gly Glu Thr  Leu Tyr His Asp Ala  Lys Thr Tyr 
    1040                 1045                 1050             


Glu Ile  Leu Lys Phe Thr Ala  Thr Asn Asn Asp Ile  Thr Gly Arg 
    1055                 1060                 1065             


Phe Glu  Val Lys Pro Ile Tyr  Cys Tyr Cys Lys Lys  Gln Leu Met 
    1070                 1075                 1080             


Val Ser  Ile Gly Thr Cys Arg  Lys Ile Gln Lys Phe  Ala Thr Asp 
    1085                 1090                 1095             


Val Leu  Gly Asn Leu Tyr Ile  Val Lys Asp Asn Val  Leu Lys Leu 
    1100                 1105                 1110             


Glu Phe  Lys 
    1115     


<210> 168
<211> 1338
<212> PRT
<213> Coprococcus catus


<220>
<223> Coprococcus catus GD/7

<400> 168
Met Lys Gln Glu Tyr Phe Leu Gly Leu Asp Met Gly Thr Gly Ser Leu 
1               5                   10                  15      


Gly Trp Ala Val Thr Asp Ser Thr Tyr Gln Val Met Arg Lys His Gly 
            20                  25                  30          


Lys Ala Leu Trp Gly Thr Arg Leu Phe Glu Ser Ala Ser Thr Ala Glu 
        35                  40                  45              


Glu Arg Arg Met Phe Arg Thr Ala Arg Arg Arg Leu Asp Arg Arg Asn 
    50                  55                  60                  


Trp Arg Ile Gln Val Leu Gln Glu Ile Phe Ser Glu Glu Ile Ser Lys 
65                  70                  75                  80  


Val Asp Pro Gly Phe Phe Leu Arg Met Lys Glu Ser Lys Tyr Tyr Pro 
                85                  90                  95      


Glu Asp Lys Arg Asp Ala Glu Gly Asn Cys Pro Glu Leu Pro Tyr Ala 
            100                 105                 110         


Leu Phe Val Asp Asp Asn Tyr Thr Asp Lys Asn Tyr His Lys Asp Tyr 
        115                 120                 125             


Pro Thr Ile Tyr His Leu Arg Lys Met Leu Met Glu Thr Thr Glu Ile 
    130                 135                 140                 


Pro Asp Ile Arg Leu Val Tyr Leu Val Leu His His Met Met Lys His 
145                 150                 155                 160 


Arg Gly His Phe Leu Leu Ser Gly Asp Ile Ser Gln Ile Lys Glu Phe 
                165                 170                 175     


Lys Ser Thr Phe Glu Gln Leu Ile Gln Asn Ile Gln Asp Glu Glu Leu 
            180                 185                 190         


Glu Trp His Ile Ser Leu Asp Asp Ala Ala Ile Gln Phe Val Glu His 
        195                 200                 205             


Val Leu Lys Asp Arg Asn Leu Thr Arg Ser Thr Lys Lys Ser Arg Leu 
    210                 215                 220                 


Ile Lys Gln Leu Asn Ala Lys Ser Ala Cys Glu Lys Ala Ile Leu Asn 
225                 230                 235                 240 


Leu Leu Ser Gly Gly Thr Val Lys Leu Ser Asp Ile Phe Asn Asn Lys 
                245                 250                 255     


Glu Leu Asp Glu Ser Glu Arg Pro Lys Val Ser Phe Ala Asp Ser Gly 
            260                 265                 270         


Tyr Asp Asp Tyr Ile Gly Ile Val Glu Ala Glu Leu Ala Glu Gln Tyr 
        275                 280                 285             


Tyr Ile Ile Ala Ser Ala Lys Ala Val Tyr Asp Trp Ser Val Leu Val 
    290                 295                 300                 


Glu Ile Leu Gly Asn Ser Val Ser Ile Ser Glu Ala Lys Ile Lys Val 
305                 310                 315                 320 


Tyr Gln Lys His Gln Ala Asp Leu Lys Thr Leu Lys Lys Ile Val Arg 
                325                 330                 335     


Gln Tyr Met Thr Lys Glu Asp Tyr Lys Arg Val Phe Val Asp Thr Glu 
            340                 345                 350         


Glu Lys Leu Asn Asn Tyr Ser Ala Tyr Ile Gly Met Thr Lys Lys Asn 
        355                 360                 365             


Gly Lys Lys Val Asp Leu Lys Ser Lys Gln Cys Thr Gln Ala Asp Phe 
    370                 375                 380                 


Tyr Asp Phe Leu Lys Lys Asn Val Ile Lys Val Ile Asp His Lys Glu 
385                 390                 395                 400 


Ile Thr Gln Glu Ile Glu Ser Glu Ile Glu Lys Glu Asn Phe Leu Pro 
                405                 410                 415     


Lys Gln Val Thr Lys Asp Asn Gly Val Ile Pro Tyr Gln Val His Asp 
            420                 425                 430         


Tyr Glu Leu Lys Lys Ile Leu Asp Asn Leu Gly Thr Arg Met Pro Phe 
        435                 440                 445             


Ile Lys Glu Asn Ala Glu Lys Ile Gln Gln Leu Phe Glu Phe Arg Ile 
    450                 455                 460                 


Pro Tyr Tyr Val Gly Pro Leu Asn Arg Val Asp Asp Gly Lys Asp Gly 
465                 470                 475                 480 


Lys Phe Thr Trp Ser Val Arg Lys Ser Asp Ala Arg Ile Tyr Pro Trp 
                485                 490                 495     


Asn Phe Thr Glu Val Ile Asp Val Glu Ala Ser Ala Glu Lys Phe Ile 
            500                 505                 510         


Arg Arg Met Thr Asn Lys Cys Thr Tyr Leu Val Gly Glu Asp Val Leu 
        515                 520                 525             


Pro Lys Asp Ser Leu Val Tyr Ser Lys Phe Met Val Leu Asn Glu Leu 
    530                 535                 540                 


Asn Asn Leu Arg Leu Asn Gly Glu Lys Ile Ser Val Glu Leu Lys Gln 
545                 550                 555                 560 


Arg Ile Tyr Glu Glu Leu Phe Cys Lys Tyr Arg Lys Val Thr Arg Lys 
                565                 570                 575     


Lys Leu Glu Arg Tyr Leu Val Ile Glu Gly Ile Ala Lys Lys Gly Val 
            580                 585                 590         


Glu Ile Thr Gly Ile Asp Gly Asp Phe Lys Ala Ser Leu Thr Ala Tyr 
        595                 600                 605             


His Asp Phe Lys Glu Arg Leu Thr Asp Val Gln Leu Ser Gln Arg Ala 
    610                 615                 620                 


Lys Glu Ala Ile Val Leu Asn Val Val Leu Phe Gly Asp Asp Lys Lys 
625                 630                 635                 640 


Leu Leu Lys Gln Arg Leu Ser Lys Met Tyr Pro Asn Leu Thr Thr Gly 
                645                 650                 655     


Gln Leu Lys Gly Ile Cys Ser Leu Ser Tyr Gln Gly Trp Gly Arg Leu 
            660                 665                 670         


Ser Lys Thr Phe Leu Glu Glu Ile Thr Val Pro Ala Pro Gly Thr Gly 
        675                 680                 685             


Glu Val Trp Asn Ile Met Thr Ala Leu Trp Gln Thr Asn Asp Asn Leu 
    690                 695                 700                 


Met Gln Leu Leu Ser Arg Asn Tyr Gly Phe Thr Asn Glu Val Glu Glu 
705                 710                 715                 720 


Phe Asn Thr Leu Lys Lys Glu Thr Asp Leu Ser Tyr Lys Thr Val Asp 
                725                 730                 735     


Glu Leu Tyr Val Ser Pro Ala Val Lys Arg Gln Ile Trp Gln Thr Leu 
            740                 745                 750         


Lys Val Val Lys Glu Ile Gln Lys Val Met Gly Asn Ala Pro Lys Arg 
        755                 760                 765             


Val Phe Val Glu Met Ala Arg Glu Lys Gln Glu Gly Lys Arg Ser Asp 
    770                 775                 780                 


Ser Arg Lys Lys Gln Leu Val Glu Leu Tyr Arg Ala Cys Lys Asn Glu 
785                 790                 795                 800 


Glu Arg Asp Trp Ile Thr Glu Leu Asn Ala Gln Ser Asp Gln Gln Leu 
                805                 810                 815     


Arg Ser Asp Lys Leu Phe Leu Tyr Tyr Ile Gln Lys Gly Arg Cys Met 
            820                 825                 830         


Tyr Ser Gly Glu Thr Ile Gln Leu Asp Glu Leu Trp Asp Asn Thr Lys 
        835                 840                 845             


Tyr Asp Ile Asp His Ile Tyr Pro Gln Ser Lys Thr Met Asp Asp Ser 
    850                 855                 860                 


Leu Asn Asn Arg Val Leu Val Lys Lys Asn Tyr Asn Ala Ile Lys Ser 
865                 870                 875                 880 


Asp Thr Tyr Pro Leu Ser Leu Asp Ile Gln Lys Lys Met Met Ser Phe 
                885                 890                 895     


Trp Lys Met Leu Gln Gln Gln Gly Phe Ile Thr Lys Glu Lys Tyr Val 
            900                 905                 910         


Arg Leu Val Arg Ser Asp Glu Leu Ser Ala Asp Glu Leu Ala Gly Phe 
        915                 920                 925             


Ile Glu Arg Gln Ile Val Glu Thr Arg Gln Ser Thr Lys Ala Val Ala 
    930                 935                 940                 


Thr Ile Leu Lys Glu Ala Leu Pro Asp Thr Glu Ile Val Tyr Val Lys 
945                 950                 955                 960 


Ala Gly Asn Val Ser Asn Phe Arg Gln Thr Tyr Glu Leu Leu Lys Val 
                965                 970                 975     


Arg Glu Met Asn Asp Leu His His Ala Lys Asp Ala Tyr Leu Asn Ile 
            980                 985                 990         


Val Val Gly Asn Ala Tyr Phe Val  Lys Phe Thr Lys Asn  Ala Ala Trp 
        995                 1000                 1005             


Phe Ile  Arg Asn Asn Pro Gly  Arg Ser Tyr Asn Leu  Lys Arg Met 
    1010                 1015                 1020             


Phe Glu  Phe Asp Ile Glu Arg  Ser Gly Glu Ile Ala  Trp Lys Ala 
    1025                 1030                 1035             


Gly Asn  Lys Gly Ser Ile Val  Thr Val Lys Lys Val  Met Gln Lys 
    1040                 1045                 1050             


Asn Asn  Ile Leu Val Thr Arg  Lys Ala Tyr Glu Val  Lys Gly Gly 
    1055                 1060                 1065             


Leu Phe  Asp Gln Gln Ile Met  Lys Lys Gly Lys Gly  Gln Val Pro 
    1070                 1075                 1080             


Ile Lys  Gly Asn Asp Glu Arg  Leu Ala Asp Ile Glu  Lys Tyr Gly 
    1085                 1090                 1095             


Gly Tyr  Asn Lys Ala Ala Gly  Thr Tyr Phe Met Leu  Val Lys Ser 
    1100                 1105                 1110             


Leu Asp  Lys Lys Gly Lys Glu  Ile Arg Thr Ile Glu  Phe Val Pro 
    1115                 1120                 1125             


Leu Tyr  Leu Lys Asn Gln Ile  Glu Ile Asn His Glu  Ser Ala Ile 
    1130                 1135                 1140             


Gln Tyr  Leu Ala Gln Glu Arg  Gly Leu Asn Ser Pro  Glu Ile Leu 
    1145                 1150                 1155             


Leu Ser  Lys Ile Lys Ile Asp  Thr Leu Phe Lys Val  Asp Gly Phe 
    1160                 1165                 1170             


Lys Met  Trp Leu Ser Gly Arg  Thr Gly Asn Gln Leu  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ala  Asn Gln Leu Ile Leu  Ser His Gln Glu Ala  Ala Ile Leu 
    1190                 1195                 1200             


Lys Gly  Val Val Lys Tyr Val  Asn Arg Lys Asn Glu  Asn Lys Asp 
    1205                 1210                 1215             


Ala Lys  Leu Ser Glu Arg Asp  Gly Met Thr Glu Glu  Lys Leu Leu 
    1220                 1225                 1230             


Gln Leu  Tyr Asp Thr Phe Leu  Asp Lys Leu Ser Asn  Thr Val Tyr 
    1235                 1240                 1245             


Ser Ile  Arg Leu Ser Ala Gln  Ile Lys Thr Leu Thr  Glu Lys Arg 
    1250                 1255                 1260             


Ala Lys  Phe Ile Gly Leu Ser  Asn Glu Asp Gln Cys  Ile Val Leu 
    1265                 1270                 1275             


Asn Glu  Ile Leu His Met Phe  Gln Cys Gln Ser Gly  Ser Ala Asn 
    1280                 1285                 1290             


Leu Lys  Leu Ile Gly Gly Pro  Gly Ser Ala Gly Ile  Leu Val Met 
    1295                 1300                 1305             


Asn Asn  Asn Ile Thr Ala Cys  Lys Gln Ile Ser Val  Ile Asn Gln 
    1310                 1315                 1320             


Ser Pro  Thr Gly Ile Tyr Glu  Lys Glu Ile Asp Leu  Ile Lys Leu 
    1325                 1330                 1335             


<210> 169
<211> 1384
<212> PRT
<213> Coriobacterium glomerans

<400> 169
Met Lys Leu Arg Gly Ile Glu Asp Asp Tyr Ser Ile Gly Leu Asp Met 
1               5                   10                  15      


Gly Thr Ser Ser Val Gly Trp Ala Val Thr Asp Glu Arg Gly Thr Leu 
            20                  25                  30          


Ala His Phe Lys Arg Lys Pro Thr Trp Gly Ser Arg Leu Phe Arg Glu 
        35                  40                  45              


Ala Gln Thr Ala Ala Val Ala Arg Met Pro Arg Gly Gln Arg Arg Arg 
    50                  55                  60                  


Tyr Val Arg Arg Arg Trp Arg Leu Asp Leu Leu Gln Lys Leu Phe Glu 
65                  70                  75                  80  


Gln Gln Met Glu Gln Ala Asp Pro Asp Phe Phe Ile Arg Leu Arg Gln 
                85                  90                  95      


Ser Arg Leu Leu Arg Asp Asp Arg Ala Glu Glu His Ala Asp Tyr Arg 
            100                 105                 110         


Trp Pro Leu Phe Asn Asp Cys Lys Phe Thr Glu Arg Asp Tyr Tyr Gln 
        115                 120                 125             


Arg Phe Pro Thr Ile Tyr His Val Arg Ser Trp Leu Met Glu Thr Asp 
    130                 135                 140                 


Glu Gln Ala Asp Ile Arg Leu Ile Tyr Leu Ala Leu His Asn Ile Val 
145                 150                 155                 160 


Lys His Arg Gly Asn Phe Leu Arg Glu Gly Gln Ser Leu Ser Ala Lys 
                165                 170                 175     


Ser Ala Arg Pro Asp Glu Ala Leu Asn His Leu Arg Glu Thr Leu Arg 
            180                 185                 190         


Val Trp Ser Ser Glu Arg Gly Phe Glu Cys Ser Ile Ala Asp Asn Gly 
        195                 200                 205             


Ser Ile Leu Ala Met Leu Thr His Pro Asp Leu Ser Pro Ser Asp Arg 
    210                 215                 220                 


Arg Lys Lys Ile Ala Pro Leu Phe Asp Val Lys Ser Asp Asp Ala Ala 
225                 230                 235                 240 


Ala Asp Lys Lys Leu Gly Ile Ala Leu Ala Gly Ala Val Ile Gly Leu 
                245                 250                 255     


Lys Thr Glu Phe Lys Asn Ile Phe Gly Asp Phe Pro Cys Glu Asp Ser 
            260                 265                 270         


Ser Ile Tyr Leu Ser Asn Asp Glu Ala Val Asp Ala Val Arg Ser Ala 
        275                 280                 285             


Cys Pro Asp Asp Cys Ala Glu Leu Phe Asp Arg Leu Cys Glu Val Tyr 
    290                 295                 300                 


Ser Ala Tyr Val Leu Gln Gly Leu Leu Ser Tyr Ala Pro Gly Gln Thr 
305                 310                 315                 320 


Ile Ser Ala Asn Met Val Glu Lys Tyr Arg Arg Tyr Gly Glu Asp Leu 
                325                 330                 335     


Ala Leu Leu Lys Lys Leu Val Lys Ile Tyr Ala Pro Asp Gln Tyr Arg 
            340                 345                 350         


Met Phe Phe Ser Gly Ala Thr Tyr Pro Gly Thr Gly Ile Tyr Asp Ala 
        355                 360                 365             


Ala Gln Ala Arg Gly Tyr Thr Lys Tyr Asn Leu Gly Pro Lys Lys Ser 
    370                 375                 380                 


Glu Tyr Lys Pro Ser Glu Ser Met Gln Tyr Asp Asp Phe Arg Lys Ala 
385                 390                 395                 400 


Val Glu Lys Leu Phe Ala Lys Thr Asp Ala Arg Ala Asp Glu Arg Tyr 
                405                 410                 415     


Arg Met Met Met Asp Arg Phe Asp Lys Gln Gln Phe Leu Arg Arg Leu 
            420                 425                 430         


Lys Thr Ser Asp Asn Gly Ser Ile Tyr His Gln Leu His Leu Glu Glu 
        435                 440                 445             


Leu Lys Ala Ile Val Glu Asn Gln Gly Arg Phe Tyr Pro Phe Leu Lys 
    450                 455                 460                 


Arg Asp Ala Asp Lys Leu Val Ser Leu Val Ser Phe Arg Ile Pro Tyr 
465                 470                 475                 480 


Tyr Val Gly Pro Leu Ser Thr Arg Asn Ala Arg Thr Asp Gln His Gly 
                485                 490                 495     


Glu Asn Arg Phe Ala Trp Ser Glu Arg Lys Pro Gly Met Gln Asp Glu 
            500                 505                 510         


Pro Ile Phe Pro Trp Asn Trp Glu Ser Ile Ile Asp Arg Ser Lys Ser 
        515                 520                 525             


Ala Glu Lys Phe Ile Leu Arg Met Thr Gly Met Cys Thr Tyr Leu Gln 
    530                 535                 540                 


Gln Glu Pro Val Leu Pro Lys Ser Ser Leu Leu Tyr Glu Glu Phe Cys 
545                 550                 555                 560 


Val Leu Asn Glu Leu Asn Gly Ala His Trp Ser Ile Asp Gly Asp Asp 
                565                 570                 575     


Glu His Arg Phe Asp Ala Ala Asp Arg Glu Gly Ile Ile Glu Glu Leu 
            580                 585                 590         


Phe Arg Arg Lys Arg Thr Val Ser Tyr Gly Asp Val Ala Gly Trp Met 
        595                 600                 605             


Glu Arg Glu Arg Asn Gln Ile Gly Ala His Val Cys Gly Gly Gln Gly 
    610                 615                 620                 


Glu Lys Gly Phe Glu Ser Lys Leu Gly Ser Tyr Ile Phe Phe Cys Lys 
625                 630                 635                 640 


Asp Val Phe Lys Val Glu Arg Leu Glu Gln Ser Asp Tyr Pro Met Ile 
                645                 650                 655     


Glu Arg Ile Ile Leu Trp Asn Thr Leu Phe Glu Asp Arg Lys Ile Leu 
            660                 665                 670         


Ser Gln Arg Leu Lys Glu Glu Tyr Gly Ser Arg Leu Ser Ala Glu Gln 
        675                 680                 685             


Ile Lys Thr Ile Cys Lys Lys Arg Phe Thr Gly Trp Gly Arg Leu Ser 
    690                 695                 700                 


Glu Lys Phe Leu Thr Gly Ile Thr Val Gln Val Asp Glu Asp Ser Val 
705                 710                 715                 720 


Ser Ile Met Asp Val Leu Arg Glu Gly Cys Pro Val Ser Gly Lys Arg 
                725                 730                 735     


Gly Arg Ala Met Val Met Met Glu Ile Leu Arg Asp Glu Glu Leu Gly 
            740                 745                 750         


Phe Gln Lys Lys Val Asp Asp Phe Asn Arg Ala Phe Phe Ala Glu Asn 
        755                 760                 765             


Ala Gln Ala Leu Gly Val Asn Glu Leu Pro Gly Ser Pro Ala Val Arg 
    770                 775                 780                 


Arg Ser Leu Asn Gln Ser Ile Arg Ile Val Asp Glu Ile Ala Ser Ile 
785                 790                 795                 800 


Ala Gly Lys Ala Pro Ala Asn Ile Phe Ile Glu Val Thr Arg Asp Glu 
                805                 810                 815     


Asp Pro Lys Lys Lys Gly Arg Arg Thr Lys Arg Arg Tyr Asn Asp Leu 
            820                 825                 830         


Lys Asp Ala Leu Glu Ala Phe Lys Lys Glu Asp Pro Glu Leu Trp Arg 
        835                 840                 845             


Glu Leu Cys Glu Thr Ala Pro Asn Asp Met Asp Glu Arg Leu Ser Leu 
    850                 855                 860                 


Tyr Phe Met Gln Arg Gly Lys Cys Leu Tyr Ser Gly Arg Ala Ile Asp 
865                 870                 875                 880 


Ile His Gln Leu Ser Asn Ala Gly Ile Tyr Glu Val Asp His Ile Ile 
                885                 890                 895     


Pro Arg Thr Tyr Val Lys Asp Asp Ser Leu Glu Asn Lys Ala Leu Val 
            900                 905                 910         


Tyr Arg Glu Glu Asn Gln Arg Lys Thr Asp Met Leu Leu Ile Asp Pro 
        915                 920                 925             


Glu Ile Arg Arg Arg Met Ser Gly Tyr Trp Arg Met Leu His Glu Ala 
    930                 935                 940                 


Lys Leu Ile Gly Asp Lys Lys Phe Arg Asn Leu Leu Arg Ser Arg Ile 
945                 950                 955                 960 


Asp Asp Lys Ala Leu Lys Gly Phe Ile Ala Arg Gln Leu Val Glu Thr 
                965                 970                 975     


Gly Gln Met Val Lys Leu Val Arg Ser Leu Leu Glu Ala Arg Tyr Pro 
            980                 985                 990         


Glu Thr Asn Ile Ile Ser Val Lys  Ala Ser Ile Ser His  Asp Leu Arg 
        995                 1000                 1005             


Thr Ala  Ala Glu Leu Val Lys  Cys Arg Glu Ala Asn  Asp Phe His 
    1010                 1015                 1020             


His Ala  His Asp Ala Phe Leu  Ala Cys Arg Val Gly  Leu Phe Ile 
    1025                 1030                 1035             


Gln Lys  Arg His Pro Cys Val  Tyr Glu Asn Pro Ile  Gly Leu Ser 
    1040                 1045                 1050             


Gln Val  Val Arg Asn Tyr Val  Arg Gln Gln Ala Asp  Ile Phe Lys 
    1055                 1060                 1065             


Arg Cys  Arg Thr Ile Pro Gly  Ser Ser Gly Phe Ile  Val Asn Ser 
    1070                 1075                 1080             


Phe Met  Thr Ser Gly Phe Asp  Lys Glu Thr Gly Glu  Ile Phe Lys 
    1085                 1090                 1095             


Asp Asp  Trp Asp Ala Glu Ala  Glu Val Glu Gly Ile  Arg Arg Ser 
    1100                 1105                 1110             


Leu Asn  Phe Arg Gln Cys Phe  Ile Ser Arg Met Pro  Phe Glu Asp 
    1115                 1120                 1125             


His Gly  Val Phe Trp Asp Ala  Thr Ile Tyr Ser Pro  Arg Ala Lys 
    1130                 1135                 1140             


Lys Thr  Ala Ala Leu Pro Leu  Lys Gln Gly Leu Asn  Pro Ser Arg 
    1145                 1150                 1155             


Tyr Gly  Ser Phe Ser Arg Glu  Gln Phe Ala Tyr Phe  Phe Ile Tyr 
    1160                 1165                 1170             


Lys Ala  Arg Asn Pro Arg Lys  Glu Gln Thr Leu Phe  Glu Phe Ala 
    1175                 1180                 1185             


Gln Val  Pro Val Arg Leu Ser  Ala Gln Ile Arg Gln  Asp Glu Asn 
    1190                 1195                 1200             


Ala Leu  Glu Arg Tyr Ala Arg  Glu Leu Ala Lys Asp  Gln Gly Leu 
    1205                 1210                 1215             


Glu Phe  Ile Arg Ile Glu Arg  Ser Lys Ile Leu Lys  Asn Gln Leu 
    1220                 1225                 1230             


Ile Glu  Ile Asp Gly Asp Arg  Leu Cys Ile Thr Gly  Lys Glu Glu 
    1235                 1240                 1245             


Val Arg  Asn Ala Cys Glu Leu  Ala Phe Ala Gln Asp  Glu Met Arg 
    1250                 1255                 1260             


Val Ile  Arg Met Leu Val Ser  Glu Lys Pro Val Ser  Arg Glu Cys 
    1265                 1270                 1275             


Val Ile  Ser Leu Phe Asn Arg  Ile Leu Leu His Gly  Asp Gln Ala 
    1280                 1285                 1290             


Ser Arg  Arg Leu Ser Lys Gln  Leu Lys Leu Ala Leu  Leu Ser Glu 
    1295                 1300                 1305             


Ala Phe  Ser Glu Ala Ser Asp  Asn Val Gln Arg Asn  Val Val Leu 
    1310                 1315                 1320             


Gly Leu  Ile Ala Ile Phe Asn  Gly Ser Thr Asn Met  Val Asn Leu 
    1325                 1330                 1335             


Ser Asp  Ile Gly Gly Ser Lys  Phe Ala Gly Asn Val  Arg Ile Lys 
    1340                 1345                 1350             


Tyr Lys  Lys Glu Leu Ala Ser  Pro Lys Val Asn Val  His Leu Ile 
    1355                 1360                 1365             


Asp Gln  Ser Val Thr Gly Met  Phe Glu Arg Arg Thr  Lys Ile Gly 
    1370                 1375                 1380             


Leu 
    


<210> 170
<211> 1099
<212> PRT
<213> Corynebacterium accolens


<220>
<223> Corynebacterium accolens ATCC 49725

<400> 170
Met Ser Leu Ser Tyr Arg Val Gly Ile Asp Val Gly Thr Tyr Ser Leu 
1               5                   10                  15      


Gly Cys Thr Ala Ile Glu Val Asp Asp Asn Asp Gln Pro Val Asn Ile 
            20                  25                  30          


Leu Ser Ser Val Ser Leu Ile His Asp Ser Gly Leu Asp Pro Asp Gln 
        35                  40                  45              


Gln Lys Arg Ala Val Thr Arg Leu Ala Ser Ser Gly Val Ala Arg Arg 
    50                  55                  60                  


Thr Arg Arg Leu Tyr Arg Arg Arg Arg Arg Arg Met Ile Asn Leu Glu 
65                  70                  75                  80  


Lys Phe Leu Thr Ser Gln Gly Trp Glu Thr Arg Pro Phe Glu His Tyr 
                85                  90                  95      


Ser Asp Pro Tyr Leu Pro Trp Asn Ala Arg Val Ala Leu Val Asn Gly 
            100                 105                 110         


Tyr Ile Ser Asp Asp Ala Gln Arg Gly Met Tyr Leu Ser Ile Ala Phe 
        115                 120                 125             


Arg His Ile Ala Asn His Arg Gly Trp Arg Asn Pro Tyr Trp Lys Val 
    130                 135                 140                 


Ser Ser Leu Tyr Ser Pro Asp Lys Pro Ser Asp Ala Phe Glu Gln Ile 
145                 150                 155                 160 


Arg Lys Glu Leu Glu Glu Ser Thr Gly His Lys Ile Pro Glu Thr Val 
                165                 170                 175     


Thr Val Gly Gln Leu Ile Ser Phe Ala Gln Phe Gly Lys Asp Arg Leu 
            180                 185                 190         


Arg Gly Gly Gly Lys Lys Lys Asp Glu Lys Lys Pro Gln Glu Gln Val 
        195                 200                 205             


Asn Gln Ala Val Ile Ser Ala Arg Leu His Gln Ile Asp His Ala Arg 
    210                 215                 220                 


Glu Ile Asn Glu Ile Cys Arg Val Gln Lys Ile Asp Asp Ala Leu Arg 
225                 230                 235                 240 


Lys Gln Ile Leu Asp Leu Val Phe Ala Ala Glu Ser Pro Lys Gly Ala 
                245                 250                 255     


Gln Ile Gly Arg Val Gly Lys Asp Pro Leu Gln Pro Lys Leu Pro Arg 
            260                 265                 270         


Ala Leu Lys Ala Ser Asp Ala Phe Gln Gln Tyr Arg Ile Val Ala Leu 
        275                 280                 285             


Ala Gly Asn Leu Arg Ile Tyr Arg Asp Gly Val Ser Thr Pro Leu Asp 
    290                 295                 300                 


Arg Asp Glu Lys Leu Ile Val Phe Asn Tyr Leu Ile Asn Leu Ser His 
305                 310                 315                 320 


Lys Glu Glu Pro Ser Trp Leu Lys Val Ala Glu Val Leu Asn Ile Asp 
                325                 330                 335     


Arg Gly Gln Leu His Gly Thr Ala Thr Met Thr Asp Asp Gly Glu Arg 
            340                 345                 350         


Ala Gly Ala Ala Pro Pro Val His Asp Thr Asn Arg Thr Ile Leu Gly 
        355                 360                 365             


Cys Lys Ile Lys Pro Leu Val His Trp Trp Glu Gly Ala Asn Asp Asp 
    370                 375                 380                 


Glu Arg Ala Ala Met Leu Lys Ala Leu Ser Asn Ser Glu Val Glu Asp 
385                 390                 395                 400 


Phe Asp Ser Pro Ala Gly Ala Gln Thr Gln Ala Phe Phe Ala Asn Leu 
                405                 410                 415     


Asp Glu Ser Glu Gln Glu Lys Leu Asp Ser Leu His Leu Pro Ile Gly 
            420                 425                 430         


Arg Ala Ala Tyr Ser Glu Asp Thr Leu Met Arg Leu Thr Ser Arg Met 
        435                 440                 445             


Leu Asp Glu Asn Leu Asp Leu Tyr Glu Ala Arg Leu Ala Glu Phe Asp 
    450                 455                 460                 


Ile Pro Lys Asp Trp Ala Pro Pro Ala Pro Arg Ile Gly Glu Pro Val 
465                 470                 475                 480 


Gly Asn Pro Ala Val Asp Arg Val Leu Lys Gly Val Ala Arg Trp Leu 
                485                 490                 495     


Glu Ala Ala Ala Asp Glu Trp Gly Ala Pro Lys Ser Val Val Ile Glu 
            500                 505                 510         


His Val Arg Asp Gly Phe Ile Ser Lys Ser Lys Ala Asn Glu Ile Asp 
        515                 520                 525             


Arg Ala Asn Asn Ala Arg His Lys Arg Asn Arg Glu Leu Phe Lys Gln 
    530                 535                 540                 


Met Gln Glu Asn Leu Gly Ile Asp Gly Lys Leu Arg Ser Ser Asp Leu 
545                 550                 555                 560 


Trp Arg Tyr Gln Ser Val Gln Arg Gln Asn Cys Gln Cys Ala Tyr Cys 
                565                 570                 575     


Gly Ser Pro Ile Thr Tyr Thr Thr Cys Glu Met Asp His Ile Val Pro 
            580                 585                 590         


Arg Ala Gly Glu Gly Ser Thr Asn Thr Arg Asp Asn Leu Val Ala Thr 
        595                 600                 605             


Cys His Arg Cys Asn Leu Ala Lys Lys Asn Ile Pro Phe Ala Val Trp 
    610                 615                 620                 


Ala Ala Gln Thr Asn Ile Pro Gly Val Ser Val Lys Glu Ala Leu Asp 
625                 630                 635                 640 


Arg Thr Arg His Trp Ser Glu Asp Ser Gly Met Thr Ser Lys Asp Phe 
                645                 650                 655     


Lys Lys Phe Arg Lys Asn Val Cys Asp Arg Leu Lys Arg Thr Val Val 
            660                 665                 670         


Asp Glu Pro Leu Asp Ala Arg Ser Met Glu Ser Val Ala Trp Met Ala 
        675                 680                 685             


Asn Glu Leu Arg Gly Arg Val Ala Gln Arg Phe Gln Glu Glu Asn Thr 
    690                 695                 700                 


Val Val Asn Val Tyr Arg Gly Glu Leu Thr Ala Glu Ala Arg Arg Ala 
705                 710                 715                 720 


Ala Gly Ile Ser Asp Lys Leu Arg Phe Ile Asp Gly Thr Gly Lys Ser 
                725                 730                 735     


Arg Leu Asp Arg Arg His His Ala Val Asp Ala Ala Val Val Ala Phe 
            740                 745                 750         


Thr Gln Asn Tyr Val Ala Glu Thr Leu Ala Ile Arg Ser Asn Lys Lys 
        755                 760                 765             


Arg Glu Ala Gln Leu Leu Gln Ala Ala Glu Gln Trp Lys Glu Phe Thr 
    770                 775                 780                 


Gly Ser Asp Ala Glu His Arg Ala Ala Trp Asn Ala Trp Leu Pro Lys 
785                 790                 795                 800 


Met Gln Lys Leu Ala Val Leu Leu Gln Lys Ala Leu Asp Glu Asp Arg 
                805                 810                 815     


Ile Ala Val Thr Ser Asn Leu Arg Leu Arg Leu Gly Asn Gly Arg Ala 
            820                 825                 830         


His Glu Asp Ser Ile Gly Glu Leu Lys Thr Ile Arg Val Gly Asp Ala 
        835                 840                 845             


Ile Ser Val Thr Asp Ile Asp Arg Ala Ser Ser Glu Ala Leu Trp Cys 
    850                 855                 860                 


Ala Leu Thr Arg Glu Pro Asp Phe Asp Glu Asn Asn Gly Leu Pro Glu 
865                 870                 875                 880 


Asn Pro Asp Arg Arg Ile Arg Ile His Gly Thr Trp Tyr Asp Ala Glu 
                885                 890                 895     


Asp Asp Ile Glu Val Phe Pro Val Gly Ala Gly Ala Ile Lys Val Arg 
            900                 905                 910         


Gly Gly Tyr Ala Glu Leu Ser Arg Phe His His Ala Arg Ile Tyr Lys 
        915                 920                 925             


Ile Pro Gly Lys Lys Ala Pro Val Tyr Cys Met Leu Arg Val Tyr Asn 
    930                 935                 940                 


Ala Asp Leu Ile Arg His Arg His Glu Asp Leu Phe Ser Val Glu Ile 
945                 950                 955                 960 


Lys Pro Gln Thr Met Ser Val Arg Gln Ala Glu Pro Lys Leu Arg Lys 
                965                 970                 975     


Ala Leu Ala Glu Asn Thr Ala Glu Tyr Leu Gly Trp Leu Val Thr Asp 
            980                 985                 990         


Asp Glu Leu Val Ile Asp Thr Ser  Asn Phe Asn Thr Gly  Gln Ile Ala 
        995                 1000                 1005             


Glu Met  Gln Ser Glu Leu Gly  Gln Val Arg Arg Trp  Arg Leu Asp 
    1010                 1015                 1020             


Gly Phe  Tyr Ser Pro Ser Thr  Leu Arg Leu Arg Pro  Leu Gln Met 
    1025                 1030                 1035             


Ser Ala  Glu Gly Leu Arg Glu  Asp Thr Ser Ile Gly  Ala Lys Lys 
    1040                 1045                 1050             


Ile Ile  Asp Arg Pro Gly Trp  Leu Pro Ala Ile Asn  Lys Leu Phe 
    1055                 1060                 1065             


Gly Glu  Gly His Val Thr Val  Val Arg Arg Asp Ala  Leu Gly Arg 
    1070                 1075                 1080             


Ala Arg  Leu Thr Ser Asn Ala  His Leu Pro Ile Ser  Trp Lys Ala 
    1085                 1090                 1095             


Glu 
    


<210> 171
<211> 1099
<212> PRT
<213> Corynebacterium accolens


<220>
<223> Corynebacterium accolens ATCC 49726

<400> 171
Met Ser Leu Leu Tyr Arg Val Gly Ile Asp Val Gly Thr Tyr Ser Leu 
1               5                   10                  15      


Gly Cys Thr Ala Ile Glu Val Asp Asp Asn Asp Gln Pro Val Ser Ile 
            20                  25                  30          


Leu Ser Ser Val Ser Leu Ile His Asp Ser Gly Leu Asp Pro Asp Gln 
        35                  40                  45              


Gln Lys Arg Ala Val Thr Arg Leu Ala Ser Ser Gly Val Ala Arg Arg 
    50                  55                  60                  


Thr Arg Arg Leu Tyr Arg Arg Arg Arg Arg Arg Met Val Lys Leu Glu 
65                  70                  75                  80  


Asn Phe Leu Thr Ala Gln Gly Trp Glu Thr Leu Pro Phe Glu Arg Tyr 
                85                  90                  95      


Ser Asp Pro Tyr Leu Pro Trp His Ala Arg Val Ala Leu Val Asn Gly 
            100                 105                 110         


Tyr Ile Ser Asp Asp Thr Gln Arg Gly Gln Tyr Leu Ser Ile Ala Phe 
        115                 120                 125             


Arg His Ile Ala Asn His Arg Gly Trp Arg Asn Pro Tyr Trp Lys Val 
    130                 135                 140                 


Ser Ser Leu Tyr Ser Pro Asp Lys Pro Ser Asp Ala Phe Glu Gln Ile 
145                 150                 155                 160 


Arg Lys Glu Leu Glu Ala Ser Thr Gly Arg Gln Ile Pro Glu Thr Ala 
                165                 170                 175     


Thr Val Gly Gln Leu Ile Ser Phe Ala Gln Phe Gly Lys Asp Arg Leu 
            180                 185                 190         


Arg Gly Gly Gly Lys Gln Lys Asp Lys Lys Lys Pro Gln Glu Gln Val 
        195                 200                 205             


Asn Gln Ala Val Ile Ser Ala Arg Leu His Gln Ile Asp His Ala Arg 
    210                 215                 220                 


Glu Ile Asn Glu Ile Cys Arg Val Gln Lys Ile Asp Asp Thr Leu Arg 
225                 230                 235                 240 


Lys Gln Ile Leu Asp Leu Val Phe Ala Ala Glu Ser Pro Lys Gly Ala 
                245                 250                 255     


Gln Lys Gly Arg Val Gly Lys Asp Pro Leu Gln Pro Lys Leu Phe Arg 
            260                 265                 270         


Ala Leu Lys Ala Ser Asp Ala Phe Gln Gln Tyr Arg Ile Ala Ala Leu 
        275                 280                 285             


Thr Gly Asn Leu Arg Ile Tyr Arg Asn Gly Val Thr Val Pro Leu Asp 
    290                 295                 300                 


Arg Asp Glu Lys Leu Ile Val Phe Asn Tyr Leu Val Asn Leu Pro Lys 
305                 310                 315                 320 


Lys Glu Glu Pro Ser Trp Leu Lys Ile Ala Glu Ile Leu Asn Ile Asp 
                325                 330                 335     


Arg Gly Gln Leu Arg Gly Thr Ala Thr Met Thr Asp Asp Gly Glu Arg 
            340                 345                 350         


Ala Gly Ala Thr Pro Pro Val His Asp Thr Asn Arg Thr Ile Leu Asp 
        355                 360                 365             


Ser Lys Val Lys Pro Leu Ala His Trp Trp Glu Asn Ala Ser Asp Asp 
    370                 375                 380                 


Glu Arg Ala Ala Met Leu Lys Ser Leu Ser Asn Ser Glu Val Glu Asp 
385                 390                 395                 400 


Phe Asp Ser Pro Ala Gly Ala Gln Val Gln Ala Phe Phe Ala Asp Leu 
                405                 410                 415     


Asp Glu Thr Glu Gln Glu Lys Leu Asp Ser Leu His Leu Pro Met Gly 
            420                 425                 430         


Arg Ala Ala Tyr Ser Glu Asp Thr Leu Met Arg Leu Thr Asn Arg Met 
        435                 440                 445             


Leu Asp Glu Asn Leu Asp Leu Tyr Glu Ala Arg Leu Ala Glu Phe Gly 
    450                 455                 460                 


Ile Pro Lys Asp Trp Ala Pro Pro Ala Pro Arg Ile Gly Glu Pro Val 
465                 470                 475                 480 


Gly Asn Pro Ala Val Asp Arg Val Leu Lys Gly Val Ala Arg Trp Leu 
                485                 490                 495     


Glu Ala Ala Ala Asp Glu Trp Gly Ala Pro Lys Ser Val Val Ile Glu 
            500                 505                 510         


His Val Arg Asp Gly Phe Val Ser Lys Ser Lys Ala Ile Glu Ile Asp 
        515                 520                 525             


Arg Ala Asn Asn Asn Arg His Lys Arg Asn Arg Glu Leu Phe Gln Lys 
    530                 535                 540                 


Met Gln Glu Asn Leu Gly Ile Glu Gly Lys Val Arg Ser Ser Asp Leu 
545                 550                 555                 560 


Trp Arg Tyr Gln Ser Val Gln Arg Gln Asn Cys Gln Cys Ala Tyr Cys 
                565                 570                 575     


Gly Ser Pro Ile Thr Tyr Thr Thr Cys Glu Met Asp His Ile Val Pro 
            580                 585                 590         


Arg Ala Gly Glu Gly Ser Thr Asn Thr Arg Asp Asn Leu Val Ala Thr 
        595                 600                 605             


Cys His Arg Cys Asn Leu Ala Lys Lys Asn Ile Pro Phe Ala Val Trp 
    610                 615                 620                 


Ala Glu Lys Ser Thr Ile Pro Gly Val Ser Val Lys Glu Ala Leu Asp 
625                 630                 635                 640 


Arg Thr Arg His Trp Ser Glu Asp Ser Gly Met Ser Lys Lys Asp Phe 
                645                 650                 655     


Gln Lys Phe Arg Lys Asn Val Cys Glu Arg Leu Asn Arg Thr Val Val 
            660                 665                 670         


Asp Glu Pro Leu Asp Ala Arg Ser Met Glu Ser Val Ala Trp Met Ala 
        675                 680                 685             


Asn Glu Leu Arg Gly Arg Val Ala Gln Arg Phe Gln Glu Glu Asn Thr 
    690                 695                 700                 


Thr Val Asn Val Tyr Arg Gly Ala Leu Thr Ala Glu Ala Arg Arg Ala 
705                 710                 715                 720 


Ala Gly Ile Thr Asp Lys Leu Arg Phe Ile Asp Gly Thr Gly Lys Ser 
                725                 730                 735     


Arg Leu Asp Arg Arg His His Ala Val Asp Ala Ala Val Val Ala Phe 
            740                 745                 750         


Ile His Asn Tyr Val Ala Glu Thr Leu Ala Ile Arg Ser Asn Lys Lys 
        755                 760                 765             


Arg Glu Ala Gln Leu Leu Gln Gly Thr Ser Gln Trp Lys Glu Phe Thr 
    770                 775                 780                 


Gly Ser Asp Asp Lys His Arg Ala Val Trp Asn Ala Trp Ile Pro Lys 
785                 790                 795                 800 


Met Gln Lys Leu Ala Val Leu Leu Gln Ile Ala Leu Asp Glu Asp Arg 
                805                 810                 815     


Ile Val Val Thr Ser Asn Leu Arg Leu Arg Leu Gly Asn Gly Arg Ala 
            820                 825                 830         


His Glu Asp Thr Ile Ser Glu Leu Lys Thr Ile Arg Val Gly Asp Ala 
        835                 840                 845             


Ile Ser Val Thr Asp Ile Asp Arg Ala Ser Ser Glu Ala Leu Trp Cys 
    850                 855                 860                 


Ala Leu Thr Arg Glu Pro Asp Phe Asp Glu Lys Asp Gly Leu Pro Glu 
865                 870                 875                 880 


Asn Pro Asn Arg Arg Ile Arg Val His Gly Thr Trp Tyr Asp Ala Glu 
                885                 890                 895     


Asp Glu Ile Glu Val Phe Pro Val Gly Ala Gly Ala Ile Lys Val Arg 
            900                 905                 910         


Gly Gly Tyr Ala Lys Leu Ser Arg Phe His His Ala Arg Val Tyr Lys 
        915                 920                 925             


Ile Pro Gly Lys Lys Ala Pro Ile Tyr Cys Met Leu Arg Val Tyr Asn 
    930                 935                 940                 


Thr Asp Leu Val Gln His Arg His Glu Asp Leu Phe Ser Val Glu Leu 
945                 950                 955                 960 


Lys Pro Gln Thr Met Ser Val Arg Gln Ala Glu Pro Lys Leu Arg Lys 
                965                 970                 975     


Ala Leu Ala Glu Asn Thr Ala Glu Tyr Leu Gly Trp Leu Val Thr Asp 
            980                 985                 990         


Asp Glu Leu Ile Ile Asp Thr Ser  Thr Phe Arg Thr Gly  Leu Ile Glu 
        995                 1000                 1005             


Glu Met  Gln Ser Glu Phe Gly  Leu Val Arg Arg Trp  Arg Leu Asp 
    1010                 1015                 1020             


Gly Phe  Asp Ser Pro Ser Leu  Leu Thr Leu Arg Pro  Leu His Met 
    1025                 1030                 1035             


Ser Ala  Glu Gly Leu Pro Asp  Asp Cys Ala Leu Gly  Ser Arg Lys 
    1040                 1045                 1050             


Ile Ile  Asp Thr Lys Gly Trp  Arg Val Ser Ile Asn  Lys Val Phe 
    1055                 1060                 1065             


Asn Ala  Gly Asn Thr Thr Val  Val Arg Arg Asp Ala  Leu Gly Arg 
    1070                 1075                 1080             


Ala Arg  Leu Thr Ser Asn Ala  His Leu Pro Ile Ser  Trp Lys Glu 
    1085                 1090                 1095             


Glu 
    


<210> 172
<211> 1084
<212> PRT
<213> Corynebacterium diphtheriae

<400> 172
Met Lys Tyr His Val Gly Ile Asp Val Gly Thr Phe Ser Val Gly Leu 
1               5                   10                  15      


Ala Ala Ile Glu Val Asp Asp Ala Gly Met Pro Ile Lys Thr Leu Ser 
            20                  25                  30          


Leu Val Ser His Ile His Asp Ser Gly Leu Asp Pro Asp Lys Ile Lys 
        35                  40                  45              


Ser Ala Val Thr Arg Leu Ala Ser Ser Gly Ile Ala Arg Arg Thr Arg 
    50                  55                  60                  


Arg Leu Tyr Arg Arg Lys Arg Arg Arg Leu Gln Gln Leu Asp Lys Phe 
65                  70                  75                  80  


Ile Gln Arg Gln Gly Trp Pro Val Ile Glu Leu Glu Asp Tyr Ser Asp 
                85                  90                  95      


Pro Leu Tyr Pro Trp Lys Val Arg Ala Glu Leu Ala Ala Ser Tyr Ile 
            100                 105                 110         


Ala Asp Glu Lys Glu Arg Gly Glu Lys Leu Ser Val Ala Leu Arg His 
        115                 120                 125             


Ile Ala Arg His Arg Gly Trp Arg Asn Pro Tyr Ala Lys Val Ser Ser 
    130                 135                 140                 


Leu Tyr Leu Pro Asp Glu Pro Ser Asp Ala Phe Lys Ala Ile Arg Glu 
145                 150                 155                 160 


Glu Ile Lys Arg Ala Ser Gly Gln Pro Val Pro Glu Thr Ala Thr Val 
                165                 170                 175     


Gly Gln Met Val Thr Leu Cys Glu Leu Gly Thr Leu Lys Leu Arg Gly 
            180                 185                 190         


Glu Gly Gly Val Leu Ser Ala Arg Leu Gln Gln Ser Asp His Ala Arg 
        195                 200                 205             


Glu Ile Gln Glu Ile Cys Arg Met Gln Glu Ile Gly Gln Glu Leu Tyr 
    210                 215                 220                 


Arg Lys Ile Ile Asp Val Val Phe Ala Ala Glu Ser Pro Lys Gly Ser 
225                 230                 235                 240 


Ala Ser Ser Arg Val Gly Lys Asp Pro Leu Gln Pro Gly Lys Asn Arg 
                245                 250                 255     


Ala Leu Lys Ala Ser Asp Ala Phe Gln Arg Tyr Arg Ile Ala Ala Leu 
            260                 265                 270         


Ile Gly Asn Leu Arg Val Arg Val Asp Gly Glu Lys Arg Ile Leu Ser 
        275                 280                 285             


Val Glu Glu Lys Asn Leu Val Phe Asp His Leu Val Asn Leu Ala Pro 
    290                 295                 300                 


Lys Lys Glu Pro Glu Trp Val Thr Ile Ala Glu Ile Leu Gly Ile Asp 
305                 310                 315                 320 


Arg Gly Gln Leu Ile Gly Thr Ala Thr Met Thr Asp Asp Gly Glu Arg 
                325                 330                 335     


Ala Gly Ala Arg Pro Pro Thr His Asp Thr Asn Arg Ser Ile Val Asn 
            340                 345                 350         


Ser Arg Ile Ala Pro Leu Val Asp Trp Trp Lys Thr Ala Ser Ala Leu 
        355                 360                 365             


Glu Gln His Ala Met Val Lys Ala Leu Ser Asn Ala Glu Val Asp Asp 
    370                 375                 380                 


Phe Asp Ser Pro Glu Gly Ala Lys Val Gln Ala Phe Phe Ala Asp Leu 
385                 390                 395                 400 


Asp Asp Asp Val His Ala Lys Leu Asp Ser Leu His Leu Pro Val Gly 
                405                 410                 415     


Arg Ala Ala Tyr Ser Glu Asp Thr Leu Val Arg Leu Thr Arg Arg Met 
            420                 425                 430         


Leu Ala Asp Gly Val Asp Leu Tyr Thr Ala Arg Leu Gln Glu Phe Gly 
        435                 440                 445             


Ile Glu Pro Ser Trp Thr Pro Pro Ala Pro Arg Ile Gly Glu Pro Val 
    450                 455                 460                 


Gly Asn Pro Ala Val Asp Arg Val Leu Lys Thr Val Ser Arg Trp Leu 
465                 470                 475                 480 


Lys Ser Ala Thr Lys Thr Trp Gly Ala Pro Glu Arg Val Ile Ile Glu 
                485                 490                 495     


His Val Arg Glu Gly Phe Val Thr Glu Lys Arg Ala Arg Glu Met Asp 
            500                 505                 510         


Gly Asp Met Arg Arg Arg Ala Ala Arg Asn Ala Lys Leu Phe Gln Glu 
        515                 520                 525             


Met Gln Glu Lys Leu Asn Val Gln Gly Lys Pro Ser Arg Ala Asp Leu 
    530                 535                 540                 


Trp Arg Tyr Gln Ser Val Gln Arg Gln Asn Cys Gln Cys Ala Tyr Cys 
545                 550                 555                 560 


Gly Ser Pro Ile Thr Phe Ser Asn Ser Glu Met Asp His Ile Val Pro 
                565                 570                 575     


Arg Ala Gly Gln Gly Ser Thr Asn Thr Arg Glu Asn Leu Val Ala Val 
            580                 585                 590         


Cys His Arg Cys Asn Gln Ser Lys Gly Asn Thr Pro Phe Ala Ile Trp 
        595                 600                 605             


Ala Lys Asn Thr Ser Ile Glu Gly Val Ser Val Lys Glu Ala Val Glu 
    610                 615                 620                 


Arg Thr Arg His Trp Val Thr Asp Thr Gly Met Arg Ser Thr Asp Phe 
625                 630                 635                 640 


Lys Lys Phe Thr Lys Ala Val Val Glu Arg Phe Gln Arg Ala Thr Met 
                645                 650                 655     


Asp Glu Glu Ile Asp Ala Arg Ser Met Glu Ser Val Ala Trp Met Ala 
            660                 665                 670         


Asn Glu Leu Arg Ser Arg Val Ala Gln His Phe Ala Ser His Gly Thr 
        675                 680                 685             


Thr Val Arg Val Tyr Arg Gly Ser Leu Thr Ala Glu Ala Arg Arg Ala 
    690                 695                 700                 


Ser Gly Ile Ser Gly Lys Leu Glu Phe Leu Asp Gly Val Gly Lys Ser 
705                 710                 715                 720 


Arg Leu Asp Arg Arg His His Ala Ile Asp Ala Ala Val Ile Ala Phe 
                725                 730                 735     


Thr Ser Asp Tyr Val Ala Glu Thr Leu Ala Val Arg Ser Asn Leu Lys 
            740                 745                 750         


Gln Ser Gln Ala His Arg Gln Glu Ala Pro Gln Trp Arg Glu Phe Thr 
        755                 760                 765             


Gly Lys Asp Ala Glu His Arg Ala Ala Trp Arg Val Trp Cys Gln Lys 
    770                 775                 780                 


Met Glu Lys Leu Ser Ala Leu Leu Thr Glu Asp Leu Arg Asp Asp Arg 
785                 790                 795                 800 


Val Val Val Met Ser Asn Val Arg Leu Arg Leu Gly Asn Gly Ser Ala 
                805                 810                 815     


His Glu Glu Thr Ile Gly Lys Leu Ser Lys Val Lys Leu Gly Ser Gln 
            820                 825                 830         


Leu Ser Val Ser Asp Ile Asp Lys Ala Ser Ser Glu Ala Leu Trp Cys 
        835                 840                 845             


Ala Leu Thr Arg Glu Pro Asp Phe Asp Pro Lys Asp Gly Leu Pro Ala 
    850                 855                 860                 


Asn Pro Glu Arg His Ile Arg Val Asn Gly Thr His Val Tyr Ala Gly 
865                 870                 875                 880 


Asp Asn Ile Gly Leu Phe Pro Val Ser Ala Gly Ser Ile Ala Leu Arg 
                885                 890                 895     


Gly Gly Tyr Ala Glu Leu Gly Ser Ser Phe His His Ala Arg Val Tyr 
            900                 905                 910         


Lys Ile Thr Ser Gly Lys Lys Pro Ala Phe Ala Met Leu Arg Val Tyr 
        915                 920                 925             


Thr Ile Asp Leu Leu Pro Tyr Arg Asn Gln Asp Leu Phe Ser Val Glu 
    930                 935                 940                 


Leu Lys Pro Gln Thr Met Ser Met Arg Gln Ala Glu Lys Lys Leu Arg 
945                 950                 955                 960 


Asp Ala Leu Ala Thr Gly Asn Ala Glu Tyr Leu Gly Trp Leu Val Val 
                965                 970                 975     


Asp Asp Glu Leu Val Val Asp Thr Ser Lys Ile Ala Thr Asp Gln Val 
            980                 985                 990         


Lys Ala Val Glu Ala Glu Leu Gly  Thr Ile Arg Arg Trp  Arg Val Asp 
        995                 1000                 1005             


Gly Phe  Phe Gly Asp Thr Arg  Leu Arg Leu Arg Pro  Leu Gln Met 
    1010                 1015                 1020             


Ser Lys  Glu Gly Ile Lys Lys  Glu Ser Ala Pro Glu  Leu Ser Lys 
    1025                 1030                 1035             


Ile Ile  Asp Arg Pro Gly Trp  Leu Pro Ala Val Asn  Lys Leu Phe 
    1040                 1045                 1050             


Ser Glu  Gly Asn Val Thr Val  Val Arg Arg Asp Ser  Leu Gly Arg 
    1055                 1060                 1065             


Val Arg  Leu Glu Ser Thr Ala  His Leu Pro Val Thr  Trp Lys Val 
    1070                 1075                 1080             


Gln 
    


<210> 173
<211> 1084
<212> PRT
<213> Corynebacterium diphtheriae

<400> 173
Met Lys Tyr His Val Gly Ile Asp Val Gly Thr Phe Ser Val Gly Leu 
1               5                   10                  15      


Ala Ala Ile Glu Val Asp Asp Ala Gly Met Pro Ile Lys Thr Leu Ser 
            20                  25                  30          


Leu Val Ser His Ile His Asp Ser Gly Leu Asp Pro Asp Lys Met Lys 
        35                  40                  45              


Ser Ala Val Thr Arg Leu Ala Ser Ser Gly Ile Ala Arg Arg Thr Arg 
    50                  55                  60                  


Arg Leu Tyr Arg Arg Lys Arg Arg Arg Leu Gln Gln Leu Asp Lys Phe 
65                  70                  75                  80  


Ile Gln Arg Gln Gly Trp Pro Val Ile Glu Leu Glu Asp Tyr Ser Asp 
                85                  90                  95      


Pro Leu Tyr Pro Trp Lys Val Arg Ala Glu Leu Ala Ala Ser Tyr Ile 
            100                 105                 110         


Ala Asp Glu Lys Glu Arg Gly Glu Lys Leu Ser Val Ala Leu Arg His 
        115                 120                 125             


Ile Ala Arg His Arg Gly Trp Arg Asn Pro Tyr Ala Lys Val Ser Ser 
    130                 135                 140                 


Leu Tyr Leu Pro Asp Glu Pro Ser Asp Ala Phe Lys Ser Ile Arg Glu 
145                 150                 155                 160 


Glu Ile Lys Arg Ala Ser Gly Gln Pro Val Pro Glu Thr Ala Thr Val 
                165                 170                 175     


Gly Gln Met Val Thr Leu Cys Glu Leu Gly Thr Leu Lys Leu Arg Gly 
            180                 185                 190         


Glu Gly Gly Val Leu Ser Ala Arg Leu Gln Gln Ser Asp His Ala Arg 
        195                 200                 205             


Glu Ile Gln Glu Ile Cys Arg Met Gln Glu Ile Gly Gln Glu Leu Tyr 
    210                 215                 220                 


Arg Lys Ile Ile Asp Val Val Phe Ala Ala Glu Ser Pro Lys Gly Ser 
225                 230                 235                 240 


Ala Ser Ser Arg Val Gly Lys Asp Pro Leu Gln Pro Gly Lys Asn Arg 
                245                 250                 255     


Ala Leu Lys Ala Ser Asp Ala Phe Gln Arg Tyr Arg Ile Ala Ala Leu 
            260                 265                 270         


Ile Gly Asn Leu Arg Val Arg Val Asp Gly Glu Lys Arg Ile Leu Ser 
        275                 280                 285             


Val Glu Glu Lys Asn Leu Val Phe Asp His Leu Val Asn Leu Ala Pro 
    290                 295                 300                 


Lys Lys Glu Pro Glu Trp Val Thr Ile Ala Glu Ile Leu Gly Ile Asp 
305                 310                 315                 320 


Arg Gly Gln Leu Ile Gly Thr Ala Thr Met Thr Asp Asp Gly Glu Arg 
                325                 330                 335     


Ala Gly Ala Arg Pro Pro Thr His Asp Thr Asn Arg Ser Ile Val Asn 
            340                 345                 350         


Ser Arg Ile Ala Pro Leu Val Asp Trp Trp Lys Thr Ala Ser Ala Leu 
        355                 360                 365             


Glu Gln His Ala Met Val Lys Ala Leu Ser Asn Ala Glu Val Asp Asp 
    370                 375                 380                 


Phe Asp Ser Pro Glu Gly Ala Lys Val Gln Ala Phe Phe Ala Asp Leu 
385                 390                 395                 400 


Asp Asp Asp Val His Ala Lys Leu Asp Ser Leu His Leu Pro Val Gly 
                405                 410                 415     


Arg Ala Ala Tyr Ser Glu Asp Thr Leu Val Arg Leu Thr Arg Arg Met 
            420                 425                 430         


Leu Ala Asp Gly Val Asp Leu Tyr Thr Ala Arg Leu Gln Glu Phe Gly 
        435                 440                 445             


Ile Glu Pro Ser Trp Thr Pro Pro Ala Pro Arg Ile Gly Glu Pro Val 
    450                 455                 460                 


Gly Asn Pro Ala Val Asp Arg Val Leu Lys Thr Val Ser Arg Trp Leu 
465                 470                 475                 480 


Glu Ser Ala Thr Lys Thr Trp Gly Ala Pro Glu Arg Val Ile Ile Glu 
                485                 490                 495     


His Val Arg Glu Gly Phe Val Thr Glu Lys Arg Ala Arg Glu Met Asp 
            500                 505                 510         


Gly Asp Met Arg Arg Arg Ala Ala Arg Asn Ala Lys Leu Phe Gln Glu 
        515                 520                 525             


Met Gln Glu Lys Leu Asn Val Gln Gly Lys Pro Ser Arg Ala Asp Leu 
    530                 535                 540                 


Trp Arg Tyr Gln Ser Val Gln Arg Gln Asn Cys Gln Cys Ala Tyr Cys 
545                 550                 555                 560 


Gly Ser Pro Ile Thr Phe Ser Asn Ser Glu Met Asp His Ile Val Pro 
                565                 570                 575     


Arg Ala Gly Gln Gly Ser Thr Asn Thr Arg Glu Asn Leu Val Ala Val 
            580                 585                 590         


Cys His Arg Cys Asn Gln Ser Lys Gly Asn Thr Pro Phe Ala Ile Trp 
        595                 600                 605             


Ala Lys Asn Thr Ser Ile Glu Gly Val Ser Val Lys Glu Ala Val Glu 
    610                 615                 620                 


Arg Thr Arg His Trp Val Thr Asp Thr Gly Met Arg Ser Thr Asp Phe 
625                 630                 635                 640 


Lys Lys Phe Thr Lys Ala Val Val Glu Arg Phe Gln Arg Ala Thr Met 
                645                 650                 655     


Asp Glu Glu Ile Asp Ala Arg Ser Met Glu Ser Val Ala Trp Met Ala 
            660                 665                 670         


Asn Glu Leu Arg Ser Arg Val Ala Gln His Phe Ala Ser His Gly Thr 
        675                 680                 685             


Thr Val Arg Val Tyr Arg Gly Ser Leu Thr Ala Glu Ala Arg Arg Ala 
    690                 695                 700                 


Ser Gly Ile Ser Gly Lys Leu Glu Phe Leu Asp Gly Val Gly Lys Ser 
705                 710                 715                 720 


Arg Leu Asp Arg Arg His His Ala Ile Asp Ala Ala Val Ile Ala Phe 
                725                 730                 735     


Thr Ser Asp Tyr Val Ala Glu Thr Leu Ala Val Arg Ser Asn Leu Lys 
            740                 745                 750         


Gln Ser Gln Ala His Arg Gln Glu Ala Pro Gln Trp Arg Glu Phe Thr 
        755                 760                 765             


Gly Lys Asp Ala Glu His Arg Ala Ala Trp Arg Val Trp Cys Gln Lys 
    770                 775                 780                 


Met Glu Lys Leu Ser Ala Leu Leu Thr Glu Asp Leu Arg Asp Asp Arg 
785                 790                 795                 800 


Val Val Val Met Ser Asn Val Arg Leu Arg Leu Gly Asn Gly Ser Ala 
                805                 810                 815     


His Glu Glu Thr Ile Gly Lys Leu Ser Lys Val Lys Leu Gly Ser Gln 
            820                 825                 830         


Leu Ser Val Ser Asp Ile Asp Lys Ala Ser Ser Glu Ala Leu Trp Cys 
        835                 840                 845             


Ala Leu Thr Arg Glu Pro Asp Phe Asp Pro Lys Asp Gly Leu Pro Ala 
    850                 855                 860                 


Asn Pro Glu Arg His Ile Arg Val Asn Gly Thr His Val Tyr Ala Gly 
865                 870                 875                 880 


Asp Asn Ile Gly Leu Phe Pro Val Ser Ala Gly Ser Ile Ala Leu Arg 
                885                 890                 895     


Gly Gly Tyr Ala Glu Leu Gly Ser Ser Phe His His Ala Arg Val Tyr 
            900                 905                 910         


Lys Ile Thr Ser Gly Lys Lys Pro Ala Phe Ala Met Leu Arg Val Tyr 
        915                 920                 925             


Thr Ile Asp Leu Leu Pro Tyr Arg Asn Gln Asp Leu Phe Ser Val Glu 
    930                 935                 940                 


Leu Lys Pro Gln Thr Met Ser Met Arg Gln Ala Glu Lys Lys Leu Arg 
945                 950                 955                 960 


Asp Ala Leu Ala Thr Gly Asn Ala Glu Tyr Leu Gly Trp Leu Val Val 
                965                 970                 975     


Asp Asp Glu Leu Val Val Asp Thr Ser Lys Ile Ala Thr Asp Gln Val 
            980                 985                 990         


Lys Ala Val Glu Ala Glu Leu Gly  Thr Ile Arg Arg Trp  Arg Val Asp 
        995                 1000                 1005             


Gly Phe  Phe Gly Asp Thr Arg  Leu Arg Leu Arg Pro  Leu Gln Met 
    1010                 1015                 1020             


Ser Lys  Glu Gly Ile Lys Lys  Glu Ser Ala Pro Glu  Leu Ser Lys 
    1025                 1030                 1035             


Ile Ile  Asp Arg Pro Gly Trp  Leu Pro Ala Val Asn  Lys Leu Phe 
    1040                 1045                 1050             


Ser Glu  Gly Asn Val Thr Val  Val Arg Arg Asp Ser  Leu Gly Arg 
    1055                 1060                 1065             


Val Arg  Leu Glu Ser Thr Ala  His Leu Pro Val Thr  Trp Lys Val 
    1070                 1075                 1080             


Gln 
    


<210> 174
<211> 1084
<212> PRT
<213> Corynebacterium diphtheriae

<400> 174
Met Lys Tyr His Val Gly Ile Asp Val Gly Thr Phe Ser Val Gly Leu 
1               5                   10                  15      


Ala Ala Ile Glu Val Asp Asp Ala Gly Met Pro Ile Lys Thr Leu Ser 
            20                  25                  30          


Leu Val Ser His Ile His Asp Ser Arg Leu Asp Pro Asp Lys Ile Lys 
        35                  40                  45              


Ser Ala Val Thr Arg Leu Ala Ser Ser Gly Ile Ala Arg Arg Thr Arg 
    50                  55                  60                  


Arg Leu Tyr Arg Arg Lys Arg Arg Arg Leu Gln Gln Leu Asp Lys Phe 
65                  70                  75                  80  


Ile Gln Arg Gln Gly Trp Pro Val Ile Glu Leu Glu Asp Tyr Ser Asp 
                85                  90                  95      


Pro Leu Tyr Pro Trp Lys Val Arg Ala Glu Leu Ala Ala Ser Tyr Ile 
            100                 105                 110         


Ala Asp Glu Lys Glu Arg Gly Glu Lys Leu Ser Val Ala Leu Arg His 
        115                 120                 125             


Ile Ala Arg His Arg Gly Trp Arg Asn Pro Tyr Ala Lys Val Ser Ser 
    130                 135                 140                 


Leu Tyr Leu Pro Asp Glu Pro Ser Asp Ala Phe Lys Ala Ile Arg Glu 
145                 150                 155                 160 


Glu Ile Lys Arg Ala Ser Gly Gln Pro Val Pro Glu Thr Ala Thr Val 
                165                 170                 175     


Gly Gln Met Val Thr Leu Cys Glu Leu Gly Thr Leu Lys Leu Arg Gly 
            180                 185                 190         


Glu Gly Gly Val Leu Ser Ala Arg Leu Gln Gln Ser Asp His Ala Arg 
        195                 200                 205             


Glu Ile Gln Glu Ile Cys Arg Met Gln Glu Ile Gly Gln Glu Leu Tyr 
    210                 215                 220                 


Arg Lys Ile Ile Asp Val Val Phe Ala Ala Glu Ser Pro Lys Gly Ser 
225                 230                 235                 240 


Ala Ser Ser Arg Val Gly Lys Asp Pro Leu Gln Pro Gly Lys Asn Arg 
                245                 250                 255     


Ala Leu Lys Ala Ser Asp Ala Phe Gln Arg Tyr Arg Ile Ala Ala Leu 
            260                 265                 270         


Ile Gly Asn Leu Arg Val Arg Val Asp Gly Glu Lys Arg Ile Leu Ser 
        275                 280                 285             


Val Glu Glu Lys Asn Leu Val Phe Asp His Leu Val Asn Leu Ala Pro 
    290                 295                 300                 


Lys Lys Glu Pro Glu Trp Val Thr Ile Ala Glu Ile Leu Gly Ile Asp 
305                 310                 315                 320 


Arg Gly Gln Leu Ile Gly Thr Ala Thr Met Thr Asp Asp Gly Glu Arg 
                325                 330                 335     


Ala Gly Ala Arg Pro Pro Thr His Asp Thr Asn Arg Ser Ile Val Asn 
            340                 345                 350         


Ser Arg Ile Ala Pro Leu Val Asp Trp Trp Lys Thr Ala Ser Ala Leu 
        355                 360                 365             


Glu Gln His Ala Met Val Lys Ala Leu Ser Asn Ala Glu Val Asp Asp 
    370                 375                 380                 


Phe Asp Ser Pro Glu Gly Ala Lys Val Gln Ala Phe Phe Ala Asp Leu 
385                 390                 395                 400 


Asp Asp Asp Val His Ala Lys Leu Asp Ser Leu His Leu Pro Val Gly 
                405                 410                 415     


Arg Ala Ala Tyr Ser Glu Asp Thr Leu Val Arg Leu Thr Arg Arg Met 
            420                 425                 430         


Leu Ala Asp Gly Val Asp Leu Tyr Thr Ala Arg Leu Gln Glu Phe Gly 
        435                 440                 445             


Ile Glu Pro Ser Trp Thr Pro Pro Ala Pro Arg Ile Gly Glu Pro Val 
    450                 455                 460                 


Gly Asn Pro Ala Val Asp Arg Val Leu Lys Thr Val Ser Arg Trp Leu 
465                 470                 475                 480 


Glu Ser Ala Thr Lys Thr Trp Gly Ala Pro Glu Arg Val Ile Ile Glu 
                485                 490                 495     


His Val Arg Glu Gly Phe Val Thr Glu Lys Arg Ala Arg Glu Met Asp 
            500                 505                 510         


Gly Asp Met Arg Arg Arg Ala Ala Arg Asn Ala Lys Leu Phe Gln Glu 
        515                 520                 525             


Met Gln Glu Lys Leu Asn Ile Gln Gly Lys Pro Ser Arg Ala Asp Leu 
    530                 535                 540                 


Trp Arg Tyr Gln Ser Val Gln Arg Gln Asn Cys Gln Cys Ala Tyr Cys 
545                 550                 555                 560 


Gly Ser Pro Ile Thr Phe Ser Asn Ser Glu Met Asp His Ile Val Pro 
                565                 570                 575     


Arg Ala Gly Gln Gly Ser Thr Asn Thr Arg Glu Asn Leu Val Ala Val 
            580                 585                 590         


Cys His Arg Cys Asn Gln Ser Lys Gly Asn Thr Pro Phe Ala Ile Trp 
        595                 600                 605             


Ala Lys Asn Thr Ser Ile Glu Gly Val Ser Val Lys Glu Ala Val Glu 
    610                 615                 620                 


Arg Thr Arg His Trp Val Thr Asp Thr Gly Met Arg Ser Thr Asp Phe 
625                 630                 635                 640 


Lys Lys Phe Thr Lys Ala Val Val Glu Arg Phe Gln Arg Val Thr Met 
                645                 650                 655     


Asp Glu Glu Ile Asp Ala Arg Ser Met Glu Ser Val Ala Trp Met Ala 
            660                 665                 670         


Asn Glu Leu Arg Ser Arg Val Ala Gln His Phe Ala Ser Arg Gly Thr 
        675                 680                 685             


Thr Val Arg Val Tyr Arg Gly Ser Leu Thr Ala Glu Ala Arg Arg Ala 
    690                 695                 700                 


Ser Gly Ile Ser Gly Lys Leu Glu Phe Leu Asp Gly Val Gly Lys Ser 
705                 710                 715                 720 


Arg Leu Asp Arg Arg His His Ala Ile Asp Ala Ala Val Ile Ala Phe 
                725                 730                 735     


Thr Ser Asp Tyr Val Ala Glu Thr Leu Ala Val Arg Ser Asn Leu Lys 
            740                 745                 750         


Gln Ser Gln Ala His Arg Gln Glu Ala Pro Gln Trp Arg Glu Phe Thr 
        755                 760                 765             


Gly Lys Asp Ala Glu His Arg Ala Ala Trp Arg Val Trp Cys Gln Lys 
    770                 775                 780                 


Met Glu Lys Leu Ser Ala Leu Leu Thr Glu Asp Leu Arg Asp Asp Arg 
785                 790                 795                 800 


Val Val Val Met Ser Asn Val Arg Leu Arg Leu Gly Asn Gly Ser Ala 
                805                 810                 815     


His Glu Glu Thr Ile Gly Lys Leu Ser Lys Val Lys Leu Gly Ser Gln 
            820                 825                 830         


Leu Ser Val Ser Asp Ile Asp Lys Ala Ser Ser Glu Ala Leu Trp Cys 
        835                 840                 845             


Ala Leu Thr Arg Glu Pro Asp Phe Asp Pro Lys Asp Gly Leu Pro Ala 
    850                 855                 860                 


Asn Pro Glu Arg His Ile Arg Val Asn Gly Thr His Val Tyr Ala Gly 
865                 870                 875                 880 


Asp Asn Ile Gly Leu Phe Pro Val Ser Ala Gly Ser Ile Ala Leu Arg 
                885                 890                 895     


Gly Gly Tyr Ala Glu Leu Gly Ser Ser Phe His His Ala Arg Val Tyr 
            900                 905                 910         


Lys Ile Thr Ser Gly Lys Lys Pro Ala Phe Ala Met Leu Arg Val Tyr 
        915                 920                 925             


Thr Ile Asp Leu Leu Pro Tyr Arg Asn Gln Asp Leu Phe Ser Val Glu 
    930                 935                 940                 


Leu Lys Pro Gln Thr Met Ser Met Arg Gln Ala Glu Lys Lys Leu Arg 
945                 950                 955                 960 


Asp Ala Leu Ala Thr Gly Asn Ala Glu Tyr Leu Gly Trp Leu Val Val 
                965                 970                 975     


Asp Asp Glu Leu Val Val Asp Thr Ser Lys Ile Ala Thr Asp Gln Val 
            980                 985                 990         


Lys Ala Val Glu Ala Glu Leu Gly  Thr Ile Arg Arg Trp  Arg Val Asp 
        995                 1000                 1005             


Gly Phe  Phe Gly Asp Thr Arg  Leu Arg Leu Arg Pro  Leu Gln Met 
    1010                 1015                 1020             


Ser Lys  Glu Gly Ile Lys Lys  Glu Ser Ala Pro Glu  Leu Ser Lys 
    1025                 1030                 1035             


Ile Ile  Asp Arg Pro Gly Trp  Leu Pro Ala Val Asn  Lys Leu Phe 
    1040                 1045                 1050             


Ser Glu  Gly Asn Val Thr Val  Val Arg Arg Asp Ser  Leu Gly Arg 
    1055                 1060                 1065             


Val Arg  Leu Glu Ser Thr Ala  His Leu Pro Val Thr  Trp Lys Val 
    1070                 1075                 1080             


Gln 
    


<210> 175
<211> 1084
<212> PRT
<213> Corynebacterium diphtheriae


<220>
<223> Corynebacterium diphtheriae bv. intermedius str. NCTC 5011

<400> 175
Met Lys Tyr His Val Gly Ile Asp Val Gly Thr Phe Ser Val Gly Leu 
1               5                   10                  15      


Ala Ala Ile Glu Val Asp Asp Ala Gly Met Pro Ile Lys Thr Leu Ser 
            20                  25                  30          


Leu Val Ser His Ile His Asp Ser Gly Leu Asp Pro Asp Glu Ile Lys 
        35                  40                  45              


Ser Ala Val Thr Arg Leu Ala Ser Ser Gly Ile Ala Arg Arg Thr Arg 
    50                  55                  60                  


Arg Leu Tyr Arg Arg Lys Arg Arg Arg Leu Gln Gln Leu Asp Lys Phe 
65                  70                  75                  80  


Ile Gln Arg Gln Gly Trp Pro Val Ile Glu Leu Glu Asp Tyr Ser Asp 
                85                  90                  95      


Pro Leu Tyr Pro Trp Lys Val Arg Ala Glu Leu Ala Ala Ser Tyr Ile 
            100                 105                 110         


Ala Asp Glu Lys Glu Arg Gly Glu Lys Leu Ser Val Ala Leu Arg His 
        115                 120                 125             


Ile Ala Arg His Arg Gly Trp Arg Asn Pro Tyr Ala Lys Val Ser Ser 
    130                 135                 140                 


Leu Tyr Leu Pro Asp Gly Pro Ser Asp Ala Phe Lys Ala Ile Arg Glu 
145                 150                 155                 160 


Glu Ile Lys Arg Ala Ser Gly Gln Pro Val Pro Glu Thr Ala Thr Val 
                165                 170                 175     


Gly Gln Met Val Thr Leu Cys Glu Leu Gly Thr Leu Lys Leu Arg Gly 
            180                 185                 190         


Glu Gly Gly Val Leu Ser Ala Arg Leu Gln Gln Ser Asp His Ala Arg 
        195                 200                 205             


Glu Ile Gln Glu Ile Cys Arg Met Gln Glu Ile Gly Gln Glu Leu Tyr 
    210                 215                 220                 


Arg Lys Ile Ile Asp Val Val Phe Ala Ala Glu Ser Pro Lys Gly Ser 
225                 230                 235                 240 


Ala Ser Ser Arg Val Gly Lys Asp Pro Leu Gln Pro Gly Lys Asn Arg 
                245                 250                 255     


Ala Leu Lys Ala Ser Asp Ala Phe Gln Arg Tyr Arg Ile Ala Ala Leu 
            260                 265                 270         


Ile Gly Asn Leu Arg Val Arg Val Asp Gly Glu Lys Arg Ile Leu Ser 
        275                 280                 285             


Val Glu Glu Lys Asn Leu Val Phe Asp His Leu Val Asn Leu Ala Pro 
    290                 295                 300                 


Lys Lys Glu Pro Glu Trp Val Thr Ile Ala Glu Ile Leu Gly Ile Asp 
305                 310                 315                 320 


Arg Gly Gln Leu Ile Gly Thr Ala Thr Met Thr Asp Asp Gly Glu Arg 
                325                 330                 335     


Ala Gly Ala Arg Pro Pro Thr His Asp Thr Asn Arg Ser Ile Val Asn 
            340                 345                 350         


Ser Arg Ile Ala Pro Leu Val Asp Trp Trp Lys Thr Ala Ser Ala Leu 
        355                 360                 365             


Glu Gln His Ala Met Val Lys Ala Leu Ser Asn Ala Glu Val Asp Asp 
    370                 375                 380                 


Phe Asp Ser Pro Glu Gly Ala Lys Val Gln Ala Phe Phe Ala Asp Leu 
385                 390                 395                 400 


Asp Asp Asp Val His Ala Lys Leu Asp Ser Leu His Leu Pro Val Gly 
                405                 410                 415     


Arg Ala Ala Tyr Ser Glu Asp Thr Leu Val Arg Leu Thr Arg Arg Met 
            420                 425                 430         


Leu Ala Asp Gly Val Asp Leu Tyr Thr Ala Arg Leu Gln Glu Phe Gly 
        435                 440                 445             


Ile Glu Pro Ser Trp Thr Pro Pro Ala Pro Arg Ile Gly Glu Pro Val 
    450                 455                 460                 


Gly Asn Pro Ala Val Asp Arg Val Leu Lys Thr Val Ser Arg Trp Leu 
465                 470                 475                 480 


Glu Ser Ala Thr Lys Thr Trp Gly Ala Pro Glu Arg Val Ile Ile Glu 
                485                 490                 495     


His Val Arg Glu Gly Phe Val Thr Glu Lys Arg Ala Arg Glu Met Asp 
            500                 505                 510         


Gly Asp Met Gln Arg Arg Ala Ala Arg Asn Ala Lys Leu Phe Gln Glu 
        515                 520                 525             


Met Gln Glu Lys Leu Asn Val Gln Gly Lys Pro Ser Arg Ala Asp Leu 
    530                 535                 540                 


Trp Arg Tyr Gln Ser Val Gln Arg Gln Asn Cys Gln Cys Ala Tyr Cys 
545                 550                 555                 560 


Gly Ser Pro Ile Thr Phe Ser Asn Ser Glu Met Asp His Ile Val Pro 
                565                 570                 575     


Arg Ala Gly Gln Gly Ser Thr Asn Thr Arg Glu Asn Leu Val Ala Val 
            580                 585                 590         


Cys His Arg Cys Asn Gln Ser Lys Gly Asn Thr Pro Phe Ala Ile Trp 
        595                 600                 605             


Ala Lys Asn Thr Ser Ile Glu Gly Val Ser Val Lys Glu Ala Val Glu 
    610                 615                 620                 


Arg Thr Arg His Trp Val Thr Asp Thr Gly Met Arg Ser Pro Asp Phe 
625                 630                 635                 640 


Lys Lys Phe Thr Lys Ala Val Val Glu Arg Phe Gln Arg Ala Thr Met 
                645                 650                 655     


Asp Glu Glu Ile Asp Ala Arg Ser Met Glu Ser Val Ala Trp Met Ala 
            660                 665                 670         


Asn Glu Leu Arg Ser Arg Val Ala Gln His Phe Ala Ser His Gly Thr 
        675                 680                 685             


Thr Val Arg Val Tyr Arg Gly Ser Leu Thr Ala Glu Ala Arg Arg Ala 
    690                 695                 700                 


Ser Gly Ile Ser Gly Lys Leu Lys Phe Phe Asp Gly Val Gly Lys Ser 
705                 710                 715                 720 


Arg Leu Asp Arg Arg His His Ala Ile Asp Ala Ala Val Ile Ala Phe 
                725                 730                 735     


Thr Ser Asp Tyr Val Ala Glu Thr Leu Ala Val Arg Ser Asn Leu Lys 
            740                 745                 750         


Gln Ser Gln Ala His Arg Gln Glu Ala Pro Gln Trp Arg Glu Phe Thr 
        755                 760                 765             


Gly Lys Asp Ala Glu His Arg Ala Ala Trp Arg Val Trp Cys Gln Lys 
    770                 775                 780                 


Met Glu Lys Leu Ser Ala Leu Leu Thr Glu Asp Leu Arg Asp Asp Arg 
785                 790                 795                 800 


Val Val Val Met Ser Asn Val Arg Leu Arg Leu Gly Asn Gly Ser Ala 
                805                 810                 815     


His Lys Glu Thr Ile Gly Lys Leu Ser Lys Val Lys Leu Gly Ser Gln 
            820                 825                 830         


Leu Ser Val Ser Asp Ile Asp Lys Ala Ser Ser Glu Ala Leu Trp Cys 
        835                 840                 845             


Ala Leu Thr Arg Glu Pro Asp Phe Asp Pro Lys Glu Gly Leu Pro Ala 
    850                 855                 860                 


Asn Pro Glu Arg His Ile Arg Val Asn Gly Thr His Val Tyr Ala Gly 
865                 870                 875                 880 


Asp Asn Ile Gly Leu Phe Pro Val Ser Ala Gly Ser Ile Ala Leu Arg 
                885                 890                 895     


Gly Gly Tyr Ala Glu Leu Gly Ser Ser Phe His His Ala Arg Val Tyr 
            900                 905                 910         


Lys Ile Thr Ser Gly Lys Lys Pro Ala Phe Ala Met Leu Arg Val Tyr 
        915                 920                 925             


Thr Ile Asp Leu Leu Pro Tyr Arg Asn Gln Asp Leu Phe Ser Val Glu 
    930                 935                 940                 


Leu Lys Pro Gln Thr Met Ser Met Arg Gln Ala Glu Lys Lys Leu Arg 
945                 950                 955                 960 


Asp Ala Leu Ala Thr Gly Asn Ala Glu Tyr Leu Gly Trp Leu Val Val 
                965                 970                 975     


Asp Asp Glu Leu Val Val Asp Thr Ser Lys Ile Ala Thr Asp Gln Val 
            980                 985                 990         


Lys Ala Val Glu Ala Glu Leu Gly  Thr Ile Arg Arg Trp  Arg Val Asp 
        995                 1000                 1005             


Gly Phe  Phe Ser Pro Ser Lys  Leu Arg Leu Arg Pro  Leu Gln Met 
    1010                 1015                 1020             


Ser Lys  Glu Gly Ile Lys Lys  Glu Ser Ala Pro Glu  Leu Ser Lys 
    1025                 1030                 1035             


Ile Ile  Asp Arg Pro Gly Trp  Leu Pro Ala Val Asn  Lys Leu Phe 
    1040                 1045                 1050             


Ser Asp  Gly Asn Val Thr Val  Val Arg Arg Asp Ser  Leu Gly Arg 
    1055                 1060                 1065             


Val Arg  Leu Glu Ser Thr Ala  His Leu Pro Val Thr  Trp Lys Val 
    1070                 1075                 1080             


Gln 
    


<210> 176
<211> 1084
<212> PRT
<213> Corynebacterium diphtheriae

<400> 176
Met Lys Tyr His Val Gly Ile Asp Val Gly Thr Phe Ser Val Gly Leu 
1               5                   10                  15      


Ala Ala Ile Glu Val Asp Asp Ala Gly Met Pro Ile Lys Thr Leu Ser 
            20                  25                  30          


Leu Val Ser His Ile His Asp Ser Gly Leu Asp Pro Asp Lys Ile Lys 
        35                  40                  45              


Ser Ala Val Thr Arg Leu Ala Ser Ser Gly Ile Ala Arg Arg Thr Arg 
    50                  55                  60                  


Arg Leu Tyr Arg Arg Lys Arg Arg Arg Leu Gln Gln Leu Asp Lys Phe 
65                  70                  75                  80  


Ile Gln Arg Gln Gly Trp Pro Val Ile Glu Leu Glu Asp Tyr Ser Asp 
                85                  90                  95      


Pro Leu Tyr Pro Trp Lys Val Arg Ala Glu Leu Ala Ala Ser Tyr Ile 
            100                 105                 110         


Ala Asp Glu Lys Glu Arg Gly Glu Lys Leu Ser Val Ala Leu Arg His 
        115                 120                 125             


Ile Ala Arg His Arg Gly Trp Arg Asn Pro Tyr Ala Lys Val Ser Ser 
    130                 135                 140                 


Leu Tyr Leu Pro Asp Glu Pro Ser Asp Ala Phe Lys Ala Ile Arg Glu 
145                 150                 155                 160 


Glu Ile Lys Arg Ala Ser Gly Gln Pro Val Pro Glu Thr Ala Thr Val 
                165                 170                 175     


Gly Gln Met Val Thr Leu Cys Glu Leu Gly Thr Leu Lys Leu Arg Gly 
            180                 185                 190         


Glu Gly Gly Val Leu Ser Ala Arg Leu Gln Gln Ser Asp His Ala Arg 
        195                 200                 205             


Glu Ile Gln Glu Ile Cys Arg Met Gln Glu Ile Gly Gln Glu Leu Tyr 
    210                 215                 220                 


Arg Lys Ile Ile Asp Val Val Phe Ala Ala Glu Ser Pro Lys Gly Ser 
225                 230                 235                 240 


Ala Ser Ser Arg Val Gly Lys Asp Pro Leu Gln Pro Gly Lys Asn Arg 
                245                 250                 255     


Ala Leu Lys Ala Ser Asp Ala Phe Gln Arg Tyr Arg Ile Ala Ala Leu 
            260                 265                 270         


Ile Gly Asn Leu Arg Val Arg Val Asp Gly Glu Lys Arg Ile Leu Ser 
        275                 280                 285             


Val Glu Glu Lys Asn Leu Val Phe Asp His Leu Val Asn Leu Ala Pro 
    290                 295                 300                 


Lys Lys Glu Pro Glu Trp Val Thr Ile Ala Glu Ile Leu Gly Ile Asp 
305                 310                 315                 320 


Arg Gly Gln Leu Ile Gly Thr Ala Thr Met Thr Asp Asp Gly Glu Arg 
                325                 330                 335     


Ala Gly Ala Arg Pro Pro Thr His Asp Thr Asn Arg Ser Ile Val Asn 
            340                 345                 350         


Ser Arg Ile Ala Pro Leu Val Asp Trp Trp Lys Thr Ala Ser Ala Leu 
        355                 360                 365             


Glu Gln His Ala Met Val Lys Ala Leu Ser Asn Ala Glu Val Asp Asp 
    370                 375                 380                 


Phe Asp Ser Pro Glu Gly Ala Lys Val Gln Ala Phe Phe Ala Asp Leu 
385                 390                 395                 400 


Asp Asp Asp Val His Ala Lys Leu Asp Ser Leu His Leu Pro Val Gly 
                405                 410                 415     


Arg Ala Ala Tyr Ser Glu Asp Thr Leu Val Arg Leu Thr Arg Arg Met 
            420                 425                 430         


Leu Ala Asp Gly Val Asp Leu Tyr Thr Ala Arg Leu Gln Glu Phe Gly 
        435                 440                 445             


Ile Glu Pro Ser Trp Thr Pro Pro Ala Pro Arg Ile Gly Glu Pro Val 
    450                 455                 460                 


Gly Asn Pro Ala Val Asp Arg Val Leu Lys Thr Val Ser Arg Trp Leu 
465                 470                 475                 480 


Glu Ser Ala Thr Lys Thr Trp Gly Ala Pro Glu Arg Val Ile Ile Glu 
                485                 490                 495     


His Val Arg Glu Gly Phe Val Thr Glu Lys Arg Ala Arg Glu Met Asp 
            500                 505                 510         


Gly Asp Met Arg Arg Arg Ala Ala Arg Asn Ala Lys Leu Phe Gln Glu 
        515                 520                 525             


Met Gln Glu Lys Leu Asn Val Gln Gly Lys Pro Ser Arg Ala Asp Leu 
    530                 535                 540                 


Trp Arg Tyr Gln Ser Val Gln Arg Gln Asn Cys Gln Cys Ala Tyr Cys 
545                 550                 555                 560 


Gly Ser Pro Ile Thr Phe Ser Asn Ser Glu Met Asp His Ile Val Pro 
                565                 570                 575     


Arg Ala Gly Gln Gly Ser Thr Asn Thr Arg Glu Asn Leu Val Ala Val 
            580                 585                 590         


Cys His Arg Cys Asn Gln Ser Lys Gly Asn Thr Pro Phe Ala Ile Trp 
        595                 600                 605             


Ala Lys Asn Thr Ser Ile Glu Gly Val Ser Val Lys Glu Ala Val Glu 
    610                 615                 620                 


Arg Thr Arg His Trp Val Thr Asp Thr Gly Met Arg Ser Thr Asp Phe 
625                 630                 635                 640 


Lys Lys Phe Thr Lys Ala Val Val Glu Arg Phe Gln Arg Ala Thr Met 
                645                 650                 655     


Asp Glu Glu Ile Asp Ala Arg Ser Met Glu Ser Val Ala Trp Met Ala 
            660                 665                 670         


Asn Glu Leu Arg Ser Arg Val Ala Gln His Phe Ala Ser His Gly Thr 
        675                 680                 685             


Thr Val Arg Val Tyr Arg Gly Ser Leu Thr Ala Glu Ala Arg Arg Ala 
    690                 695                 700                 


Ser Gly Ile Ser Gly Lys Leu Glu Phe Leu Asp Gly Val Gly Lys Ser 
705                 710                 715                 720 


Arg Leu Asp Arg Arg His His Ala Ile Asp Ala Ala Val Ile Ala Phe 
                725                 730                 735     


Thr Ser Asp Tyr Val Ala Glu Thr Leu Ala Val Arg Ser Asn Leu Lys 
            740                 745                 750         


Gln Ser Gln Ala His Arg Gln Glu Ala Pro Gln Trp Arg Glu Phe Thr 
        755                 760                 765             


Gly Lys Asp Ala Glu His Arg Ala Ala Trp Arg Val Trp Cys Gln Lys 
    770                 775                 780                 


Met Glu Lys Leu Ser Ala Leu Leu Thr Glu Asp Leu Arg Asp Asp Arg 
785                 790                 795                 800 


Val Val Val Met Ser Asn Val Arg Leu Arg Leu Gly Asn Gly Ser Ala 
                805                 810                 815     


His Glu Glu Thr Ile Gly Lys Leu Ser Lys Val Lys Leu Gly Ser Gln 
            820                 825                 830         


Leu Ser Val Ser Asp Ile Asp Lys Ala Ser Ser Glu Ala Leu Trp Cys 
        835                 840                 845             


Ala Leu Thr Arg Glu Pro Asp Phe Asp Pro Lys Asp Gly Leu Pro Ala 
    850                 855                 860                 


Asn Pro Glu Arg His Ile Arg Val Asn Gly Thr His Val Tyr Ala Gly 
865                 870                 875                 880 


Asp Asn Ile Gly Leu Phe Pro Val Ser Ala Gly Ser Ile Ala Leu Arg 
                885                 890                 895     


Gly Gly Tyr Ala Glu Leu Gly Ser Ser Phe His His Ala Arg Val Tyr 
            900                 905                 910         


Lys Ile Thr Ser Gly Lys Lys Pro Ala Phe Ala Met Leu Arg Val Tyr 
        915                 920                 925             


Thr Ile Asp Leu Leu Pro Tyr Arg Asn Gln Asp Leu Phe Ser Val Glu 
    930                 935                 940                 


Leu Lys Pro Gln Thr Met Ser Met Arg Gln Ala Glu Lys Lys Leu Arg 
945                 950                 955                 960 


Asp Ala Leu Ala Thr Gly Asn Ala Glu Tyr Leu Gly Trp Leu Val Val 
                965                 970                 975     


Asp Asp Glu Leu Val Val Asp Thr Ser Lys Ile Ala Thr Asp Gln Val 
            980                 985                 990         


Lys Ala Val Glu Ala Glu Leu Gly  Thr Ile Arg Arg Trp  Arg Val Asp 
        995                 1000                 1005             


Gly Phe  Phe Gly Asp Thr Arg  Leu Arg Leu Arg Pro  Leu Gln Met 
    1010                 1015                 1020             


Ser Lys  Glu Gly Ile Lys Lys  Glu Ser Ala Pro Glu  Leu Ser Lys 
    1025                 1030                 1035             


Ile Ile  Asp Arg Pro Gly Trp  Leu Pro Ala Val Asn  Lys Leu Phe 
    1040                 1045                 1050             


Ser Glu  Gly Asn Val Thr Val  Val Arg Arg Asp Ser  Leu Gly Arg 
    1055                 1060                 1065             


Val Arg  Leu Glu Ser Thr Ala  His Leu Pro Val Thr  Trp Lys Val 
    1070                 1075                 1080             


Gln 
    


<210> 177
<211> 1084
<212> PRT
<213> Corynebacterium diphtheriae

<400> 177
Met Lys Tyr His Val Gly Ile Asp Val Gly Thr Phe Ser Val Gly Leu 
1               5                   10                  15      


Ala Ala Ile Glu Val Asp Asp Ala Gly Met Pro Ile Lys Thr Leu Ser 
            20                  25                  30          


Leu Val Ser His Ile His Asp Ser Gly Leu Asp Pro Asp Glu Ile Lys 
        35                  40                  45              


Ser Ala Val Thr Arg Leu Ala Ser Ser Gly Ile Ala Arg Arg Thr Arg 
    50                  55                  60                  


Arg Leu Tyr Arg Arg Lys Arg Arg Arg Leu Gln Gln Leu Asp Lys Phe 
65                  70                  75                  80  


Ile Gln Arg Gln Gly Trp Pro Val Ile Glu Leu Glu Asp Tyr Ser Asp 
                85                  90                  95      


Pro Leu Tyr Pro Trp Lys Val Arg Ala Glu Leu Ala Ala Ser Tyr Ile 
            100                 105                 110         


Ala Asp Glu Lys Glu Arg Gly Glu Lys Leu Ser Val Ala Leu Arg His 
        115                 120                 125             


Ile Ala Arg His Arg Gly Trp Arg Asn Pro Tyr Ala Lys Val Ser Ser 
    130                 135                 140                 


Leu Tyr Leu Pro Asp Gly Pro Ser Asp Ala Phe Lys Ala Ile Arg Glu 
145                 150                 155                 160 


Glu Ile Lys Arg Ala Ser Gly Gln Pro Val Pro Glu Thr Ala Thr Val 
                165                 170                 175     


Gly Gln Met Val Thr Leu Cys Glu Leu Gly Thr Leu Lys Leu Arg Gly 
            180                 185                 190         


Glu Gly Gly Val Leu Ser Ala Arg Leu Gln Gln Ser Asp His Ala Arg 
        195                 200                 205             


Glu Ile Gln Glu Ile Cys Arg Met Gln Glu Ile Gly Gln Glu Leu Tyr 
    210                 215                 220                 


Arg Lys Ile Ile Asp Val Val Phe Ala Ala Glu Ser Pro Lys Gly Ser 
225                 230                 235                 240 


Ala Ser Ser Arg Val Gly Lys Asp Pro Leu Gln Pro Gly Lys Asn Arg 
                245                 250                 255     


Ala Leu Lys Ala Ser Asp Ala Phe Gln Arg Tyr Arg Ile Ala Ala Leu 
            260                 265                 270         


Ile Gly Asn Leu Arg Val Trp Val Asp Gly Glu Lys Arg Ile Leu Ser 
        275                 280                 285             


Val Glu Glu Lys Asn Leu Val Phe Asp His Leu Val Asn Leu Thr Pro 
    290                 295                 300                 


Lys Lys Glu Pro Glu Trp Val Thr Ile Ala Glu Ile Leu Gly Ile Asp 
305                 310                 315                 320 


Arg Gly Gln Leu Ile Gly Thr Ala Thr Met Thr Asp Asp Gly Glu Arg 
                325                 330                 335     


Ala Gly Ala Arg Pro Pro Thr His Asp Thr Asn Arg Ser Ile Val Asn 
            340                 345                 350         


Ser Arg Ile Ala Pro Leu Val Asp Trp Trp Lys Thr Ala Ser Ala Leu 
        355                 360                 365             


Glu Gln His Ala Met Val Lys Ala Leu Ser Asn Ala Glu Val Asp Asp 
    370                 375                 380                 


Phe Asp Ser Pro Glu Arg Ala Lys Val Gln Ala Phe Phe Ala Asp Leu 
385                 390                 395                 400 


Asp Asp Asp Val His Ala Lys Leu Asp Ser Leu His Leu Pro Val Gly 
                405                 410                 415     


Arg Ala Ala Tyr Ser Glu Asp Thr Leu Val Arg Leu Thr Arg Arg Met 
            420                 425                 430         


Leu Ser Asp Gly Val Asp Leu Tyr Thr Ala Arg Leu Gln Glu Phe Gly 
        435                 440                 445             


Ile Glu Pro Ser Trp Thr Pro Pro Thr Pro Arg Ile Gly Glu Pro Val 
    450                 455                 460                 


Gly Asn Pro Ala Val Asp Arg Val Leu Lys Thr Val Ser Arg Trp Leu 
465                 470                 475                 480 


Glu Ser Ala Thr Lys Thr Trp Gly Ala Pro Glu Arg Val Ile Ile Glu 
                485                 490                 495     


His Val Arg Glu Gly Phe Val Thr Glu Lys Arg Ala Arg Glu Met Asp 
            500                 505                 510         


Gly Asp Met Arg Arg Arg Ala Ala Arg Asn Ala Lys Leu Phe Gln Glu 
        515                 520                 525             


Met Gln Glu Lys Leu Asn Val Gln Gly Lys Pro Ser Arg Ala Asp Leu 
    530                 535                 540                 


Trp Arg Tyr Gln Ser Val Gln Arg Gln Asn Cys Gln Cys Ala Tyr Cys 
545                 550                 555                 560 


Gly Ser Pro Ile Thr Phe Ser Asn Ser Glu Met Asp His Ile Val Pro 
                565                 570                 575     


Arg Ala Gly Gln Gly Ser Thr Asn Thr Arg Glu Asn Leu Val Ala Val 
            580                 585                 590         


Cys His Arg Cys Asn Gln Ser Lys Gly Asn Thr Pro Phe Ala Ile Trp 
        595                 600                 605             


Ala Lys Asn Thr Ser Ile Glu Gly Val Ser Val Lys Glu Ala Val Glu 
    610                 615                 620                 


Arg Thr Arg His Trp Val Thr Asp Thr Gly Met Arg Ser Thr Asp Phe 
625                 630                 635                 640 


Lys Lys Phe Thr Lys Ala Val Val Glu Arg Phe Gln Arg Ala Thr Met 
                645                 650                 655     


Asp Glu Glu Ile Asp Ala Arg Ser Met Glu Ser Val Ala Trp Met Ala 
            660                 665                 670         


Asn Glu Leu Arg Ser Arg Val Ala Gln His Phe Ala Ser His Gly Thr 
        675                 680                 685             


Thr Val Arg Val Tyr Arg Gly Ser Leu Thr Ala Glu Ala Arg Arg Ala 
    690                 695                 700                 


Ser Gly Ile Ser Gly Lys Leu Glu Phe Leu Asp Gly Val Gly Lys Ser 
705                 710                 715                 720 


Arg Leu Asp Arg Arg His His Ala Ile Asp Ala Ala Val Ile Ala Phe 
                725                 730                 735     


Thr Ser Asp Tyr Val Ala Glu Thr Leu Ala Val Arg Ser Asn Leu Lys 
            740                 745                 750         


Gln Ser Gln Ala His Arg Gln Glu Ala Pro Gln Trp Arg Glu Phe Thr 
        755                 760                 765             


Gly Lys Asp Ala Glu His Arg Ala Thr Trp Arg Val Trp Cys Gln Lys 
    770                 775                 780                 


Met Glu Lys Leu Ser Ala Leu Leu Thr Glu Asp Leu Arg Asp Asp Arg 
785                 790                 795                 800 


Val Val Val Met Ser Asn Val Arg Leu Arg Leu Gly Asn Gly Ser Ala 
                805                 810                 815     


His Glu Glu Thr Ile Gly Lys Leu Ser Lys Val Lys Leu Gly Ser Gln 
            820                 825                 830         


Leu Ser Val Ser Asp Ile Asp Lys Ala Ser Ser Glu Ala Leu Trp Cys 
        835                 840                 845             


Ala Leu Thr Arg Glu Pro Asp Phe Asp Pro Lys Asp Gly Leu Pro Ala 
    850                 855                 860                 


Asn Pro Glu Arg His Ile Arg Val Asn Gly Thr His Val Tyr Ala Gly 
865                 870                 875                 880 


Asp Asn Ile Gly Leu Phe Pro Val Ser Ala Gly Ser Ile Ala Leu Arg 
                885                 890                 895     


Gly Gly Tyr Ala Glu Leu Gly Ser Ser Phe His His Ala Arg Val Tyr 
            900                 905                 910         


Lys Ile Thr Ser Gly Lys Lys Pro Ala Phe Ala Met Leu Arg Val Tyr 
        915                 920                 925             


Thr Ile Asp Leu Leu Pro Tyr Arg Asn Gln Asp Leu Phe Ser Val Glu 
    930                 935                 940                 


Leu Lys Pro Gln Thr Met Ser Met Arg Gln Ala Glu Lys Lys Leu Arg 
945                 950                 955                 960 


Asp Ala Leu Ala Thr Gly Asn Ala Glu Tyr Leu Gly Trp Leu Val Val 
                965                 970                 975     


Asp Asp Glu Leu Val Val Asp Thr Ser Lys Ile Ala Thr Asp Gln Val 
            980                 985                 990         


Lys Ala Val Glu Ala Glu Leu Gly  Thr Ile Arg Arg Trp  Arg Val Asp 
        995                 1000                 1005             


Gly Phe  Phe Gly Asp Thr Arg  Leu Arg Leu Arg Pro  Leu Gln Met 
    1010                 1015                 1020             


Ser Lys  Glu Gly Ile Lys Lys  Glu Ser Ala Pro Glu  Leu Ser Lys 
    1025                 1030                 1035             


Ile Ile  Asp Arg Pro Gly Trp  Leu Pro Ala Val Asn  Lys Leu Phe 
    1040                 1045                 1050             


Ser Glu  Gly Asn Val Thr Val  Val Arg Arg Asp Ser  Leu Gly Arg 
    1055                 1060                 1065             


Val Arg  Leu Glu Ser Thr Ala  His Leu Pro Val Thr  Trp Lys Val 
    1070                 1075                 1080             


Gln 
    


<210> 178
<211> 1084
<212> PRT
<213> Corynebacterium diphtheriae

<400> 178
Met Lys Tyr His Val Gly Ile Asp Val Gly Thr Phe Ser Val Gly Leu 
1               5                   10                  15      


Ala Ala Ile Glu Val Asp Asp Ala Gly Met Pro Ile Lys Thr Leu Ser 
            20                  25                  30          


Leu Val Ser His Ile His Asp Ser Gly Leu Asp Pro Asp Glu Ile Lys 
        35                  40                  45              


Ser Ala Val Thr Arg Leu Ala Ser Ser Gly Ile Ala Arg Arg Thr Arg 
    50                  55                  60                  


Arg Leu Tyr Arg Arg Lys Arg Arg Arg Leu Gln Gln Leu Asp Lys Phe 
65                  70                  75                  80  


Ile Gln Arg Gln Gly Trp Pro Val Ile Glu Leu Glu Asp Tyr Ser Asp 
                85                  90                  95      


Pro Leu Tyr Pro Trp Lys Val Arg Ala Glu Leu Ala Ala Ser Tyr Ile 
            100                 105                 110         


Ala Asp Glu Lys Glu Arg Gly Glu Lys Leu Ser Val Ala Leu Arg His 
        115                 120                 125             


Ile Ala Arg His Arg Gly Trp Arg Asn Pro Tyr Ala Lys Val Ser Ser 
    130                 135                 140                 


Leu Tyr Leu Pro Asp Gly Pro Ser Asp Ala Phe Lys Ala Ile Arg Glu 
145                 150                 155                 160 


Glu Ile Lys Arg Ala Ser Gly Gln Pro Val Pro Glu Thr Ala Thr Val 
                165                 170                 175     


Gly Gln Met Val Thr Leu Cys Glu Leu Gly Thr Leu Lys Leu Arg Gly 
            180                 185                 190         


Glu Gly Gly Val Leu Ser Ala Arg Leu Gln Gln Ser Asp Tyr Ala Arg 
        195                 200                 205             


Glu Ile Gln Glu Ile Cys Arg Met Gln Glu Ile Gly Gln Glu Leu Tyr 
    210                 215                 220                 


Arg Lys Ile Ile Asp Val Val Phe Ala Ala Glu Ser Pro Lys Gly Ser 
225                 230                 235                 240 


Ala Ser Ser Arg Val Gly Lys Asp Pro Leu Gln Pro Gly Lys Asn Arg 
                245                 250                 255     


Ala Leu Lys Ala Ser Asp Ala Phe Gln Arg Tyr Arg Ile Ala Ala Leu 
            260                 265                 270         


Ile Gly Asn Leu Arg Val Arg Val Asp Gly Glu Lys Arg Ile Leu Ser 
        275                 280                 285             


Val Glu Glu Lys Asn Leu Val Phe Asp His Leu Val Asn Leu Thr Pro 
    290                 295                 300                 


Lys Lys Glu Pro Glu Trp Val Thr Ile Ala Glu Ile Leu Gly Ile Asp 
305                 310                 315                 320 


Arg Gly Gln Leu Ile Gly Thr Ala Thr Met Thr Asp Asp Gly Glu Arg 
                325                 330                 335     


Ala Gly Ala Arg Pro Pro Thr His Asp Thr Asn Arg Ser Ile Val Asn 
            340                 345                 350         


Ser Arg Ile Ala Pro Leu Val Asp Trp Trp Lys Thr Ala Ser Ala Leu 
        355                 360                 365             


Glu Gln His Ala Met Val Lys Ala Leu Ser Asn Ala Glu Val Asp Asp 
    370                 375                 380                 


Phe Asp Ser Pro Glu Gly Ala Lys Val Gln Ala Phe Phe Ala Asp Leu 
385                 390                 395                 400 


Asp Asp Asp Val His Ala Lys Leu Asp Ser Leu His Leu Pro Val Gly 
                405                 410                 415     


Arg Ala Ala Tyr Ser Glu Asp Thr Leu Val Arg Leu Thr Arg Arg Met 
            420                 425                 430         


Leu Ser Asp Gly Val Asp Leu Tyr Thr Ala Arg Leu Gln Glu Phe Gly 
        435                 440                 445             


Ile Glu Pro Ser Trp Thr Pro Pro Thr Pro Arg Ile Gly Glu Pro Val 
    450                 455                 460                 


Gly Asn Pro Ala Val Asp Arg Val Leu Lys Thr Val Ser Arg Trp Leu 
465                 470                 475                 480 


Glu Ser Ala Thr Lys Thr Trp Gly Ala Pro Glu Arg Val Ile Ile Glu 
                485                 490                 495     


His Val Arg Glu Gly Phe Val Thr Glu Lys Arg Ala Arg Glu Met Asp 
            500                 505                 510         


Gly Asp Met Arg Arg Arg Ala Ala Arg Asn Ala Lys Leu Phe Gln Glu 
        515                 520                 525             


Met Gln Glu Lys Leu Asn Val Gln Gly Lys Pro Ser Arg Ala Asp Leu 
    530                 535                 540                 


Trp Arg Tyr Gln Ser Val Gln Arg Gln Asn Cys Gln Cys Ala Tyr Cys 
545                 550                 555                 560 


Gly Ser Pro Ile Thr Phe Ser Asn Ser Glu Met Asp His Ile Val Pro 
                565                 570                 575     


Arg Ala Gly Gln Gly Ser Thr Asn Thr Arg Glu Asn Leu Val Ala Val 
            580                 585                 590         


Cys His Arg Cys Asn Gln Ser Lys Gly Asn Thr Pro Phe Ala Ile Trp 
        595                 600                 605             


Ala Lys Asn Thr Ser Ile Glu Gly Val Ser Val Lys Glu Ala Val Glu 
    610                 615                 620                 


Arg Thr Arg His Trp Val Thr Asp Thr Gly Met Arg Ser Thr Asp Phe 
625                 630                 635                 640 


Lys Lys Phe Thr Lys Ala Val Val Glu Arg Phe Gln Arg Ala Thr Met 
                645                 650                 655     


Asp Glu Glu Ile Asp Ala Arg Ser Met Glu Ser Val Ala Trp Met Ala 
            660                 665                 670         


Asn Glu Leu Arg Ser Arg Val Ala Gln His Phe Ala Ser His Gly Thr 
        675                 680                 685             


Thr Val Arg Val Tyr Arg Gly Ser Leu Thr Ala Glu Ala Arg Arg Ala 
    690                 695                 700                 


Ser Gly Ile Ser Gly Lys Leu Lys Phe Phe Asp Gly Val Gly Lys Ser 
705                 710                 715                 720 


Arg Leu Asp Arg Arg His His Ala Ile Asp Ala Ala Val Ile Ala Phe 
                725                 730                 735     


Thr Ser Asp Tyr Val Ala Glu Thr Leu Ala Val Arg Ser Asn Leu Lys 
            740                 745                 750         


Gln Ser Gln Ala His Arg Gln Glu Ala Pro Gln Trp Arg Glu Phe Thr 
        755                 760                 765             


Gly Lys Asp Ala Glu His Arg Ala Ala Trp Arg Val Trp Cys Gln Lys 
    770                 775                 780                 


Met Glu Lys Leu Ser Ala Leu Leu Thr Glu Asp Leu Arg Asp Asp Arg 
785                 790                 795                 800 


Val Val Val Met Ser Asn Val Arg Leu Arg Leu Gly Asn Gly Ser Ala 
                805                 810                 815     


His Lys Glu Thr Ile Gly Lys Leu Ser Lys Val Lys Leu Ser Ser Gln 
            820                 825                 830         


Leu Ser Val Ser Asp Ile Asp Lys Ala Ser Ser Glu Ala Leu Trp Cys 
        835                 840                 845             


Ala Leu Thr Arg Glu Pro Gly Phe Asp Pro Lys Glu Gly Leu Pro Ala 
    850                 855                 860                 


Asn Pro Glu Arg His Ile Arg Val Asn Gly Thr His Val Tyr Ala Gly 
865                 870                 875                 880 


Asp Asn Ile Gly Leu Phe Pro Val Ser Ala Gly Ser Ile Ala Leu Arg 
                885                 890                 895     


Gly Gly Tyr Ala Glu Leu Gly Ser Ser Phe His His Ala Arg Val Tyr 
            900                 905                 910         


Lys Ile Thr Ser Gly Lys Lys Pro Ala Phe Ala Met Leu Arg Val Tyr 
        915                 920                 925             


Thr Ile Asp Leu Leu Pro Tyr Arg Asn Gln Asp Leu Phe Ser Val Glu 
    930                 935                 940                 


Leu Lys Pro Gln Thr Met Ser Met Arg Gln Ala Glu Lys Lys Leu Arg 
945                 950                 955                 960 


Asp Ala Leu Ala Thr Gly Asn Ala Glu Tyr Leu Gly Trp Leu Val Val 
                965                 970                 975     


Asp Asp Glu Leu Val Val Asp Thr Ser Lys Ile Ala Thr Asp Gln Val 
            980                 985                 990         


Lys Ala Val Glu Ala Glu Leu Gly  Thr Ile Arg Arg Trp  Arg Val Asp 
        995                 1000                 1005             


Gly Phe  Phe Ser Pro Ser Lys  Leu Arg Leu Arg Pro  Leu Gln Met 
    1010                 1015                 1020             


Ser Lys  Glu Gly Ile Lys Lys  Glu Ser Ala Pro Glu  Leu Ser Lys 
    1025                 1030                 1035             


Ile Ile  Asp Arg Pro Gly Trp  Leu Pro Ala Val Asn  Lys Leu Phe 
    1040                 1045                 1050             


Ser Asp  Gly Asn Val Thr Val  Val Arg Arg Asp Ser  Leu Gly Arg 
    1055                 1060                 1065             


Val Arg  Leu Glu Ser Thr Ala  His Leu Pro Val Thr  Trp Lys Val 
    1070                 1075                 1080             


Gln 
    


<210> 179
<211> 1084
<212> PRT
<213> Corynebacterium diphtheriae

<400> 179
Met Lys Tyr His Val Gly Ile Asp Val Gly Thr Phe Ser Val Gly Leu 
1               5                   10                  15      


Ala Ala Ile Glu Val Asp Asp Ala Gly Met Pro Ile Lys Thr Leu Ser 
            20                  25                  30          


Leu Val Ser His Ile His Asp Ser Gly Leu Asp Pro Asp Lys Met Lys 
        35                  40                  45              


Ser Ala Val Thr Arg Leu Ala Ser Ser Gly Ile Ala Arg Arg Thr Arg 
    50                  55                  60                  


Arg Leu Tyr Arg Arg Lys Arg Arg Arg Leu Gln Gln Leu Asp Lys Phe 
65                  70                  75                  80  


Ile Gln Arg Gln Gly Trp Pro Val Ile Glu Leu Glu Asp Tyr Ser Asp 
                85                  90                  95      


Pro Leu Tyr Pro Trp Lys Val Arg Ala Glu Leu Ala Ala Ser Tyr Ile 
            100                 105                 110         


Ala Asp Glu Lys Glu Arg Gly Glu Lys Leu Ser Val Ala Leu Arg His 
        115                 120                 125             


Ile Ala Arg His Arg Gly Trp Arg Asn Pro Tyr Ala Lys Val Ser Ser 
    130                 135                 140                 


Leu Tyr Leu Pro Asp Glu Pro Ser Asp Ala Phe Lys Ser Ile Arg Glu 
145                 150                 155                 160 


Glu Ile Lys Arg Ala Ser Gly Gln Pro Val Pro Glu Thr Ala Thr Val 
                165                 170                 175     


Gly Gln Met Val Thr Leu Cys Glu Leu Gly Thr Leu Lys Leu Arg Gly 
            180                 185                 190         


Glu Gly Gly Val Leu Ser Ala Arg Leu Gln Gln Ser Asp His Ala Arg 
        195                 200                 205             


Glu Ile Gln Glu Ile Cys Arg Met Gln Glu Ile Gly Gln Glu Leu Tyr 
    210                 215                 220                 


Arg Lys Ile Ile Asp Val Val Phe Ala Ala Glu Ser Pro Lys Gly Ser 
225                 230                 235                 240 


Ala Ser Ser Arg Val Gly Lys Asp Pro Leu Gln Pro Gly Lys Asn Arg 
                245                 250                 255     


Ala Leu Lys Ala Ser Asp Ser Phe Gln Arg Tyr Arg Ile Ala Ala Leu 
            260                 265                 270         


Ile Ser Asn Leu Arg Val Arg Val Asp Gly Glu Lys Arg Ile Leu Ser 
        275                 280                 285             


Val Glu Glu Lys Asn Leu Val Phe Asp His Leu Val Asn Leu Ala Pro 
    290                 295                 300                 


Lys Lys Glu Pro Glu Trp Val Thr Ile Ala Glu Ile Leu Gly Ile Asp 
305                 310                 315                 320 


Arg Gly Gln Leu Ile Gly Thr Ala Thr Met Thr Asp Asp Gly Glu Arg 
                325                 330                 335     


Ala Gly Ala Arg Pro Pro Thr His Asp Thr Asn Arg Ser Ile Val Asn 
            340                 345                 350         


Ser Arg Ile Ala Pro Leu Val Asp Trp Trp Lys Thr Ala Ser Ala Leu 
        355                 360                 365             


Glu Gln His Ala Met Val Lys Ala Leu Ser Asn Ala Glu Val Asp Asp 
    370                 375                 380                 


Phe Asp Ser Pro Glu Gly Ala Lys Val Gln Ala Phe Phe Ala Asp Leu 
385                 390                 395                 400 


Asp Asp Asp Val His Ala Lys Leu Asp Ser Leu His Leu Pro Val Gly 
                405                 410                 415     


Arg Ala Ala Tyr Ser Glu Asp Thr Leu Val Arg Leu Thr Arg Arg Met 
            420                 425                 430         


Leu Ala Asp Gly Val Asp Leu Tyr Thr Ala Arg Leu Gln Glu Phe Gly 
        435                 440                 445             


Ile Glu Pro Ser Trp Thr Pro Pro Ala Pro Arg Ile Gly Glu Pro Val 
    450                 455                 460                 


Gly Asn Pro Ala Val Asp Arg Val Leu Lys Thr Val Ser Arg Trp Leu 
465                 470                 475                 480 


Glu Ser Ala Thr Lys Thr Trp Gly Ala Pro Glu Arg Val Ile Ile Glu 
                485                 490                 495     


His Val Arg Asp Gly Phe Val Thr Glu Lys Arg Ala Arg Glu Met Asp 
            500                 505                 510         


Gly Asp Met Arg Arg Arg Ala Ala Arg Asn Ala Lys Leu Phe Gln Glu 
        515                 520                 525             


Met Gln Glu Lys Leu Asn Val Gln Gly Lys Pro Ser Arg Ala Asp Leu 
    530                 535                 540                 


Trp Arg Tyr Gln Ser Val Gln Arg Gln Asn Cys Gln Cys Ala Tyr Cys 
545                 550                 555                 560 


Gly Ser Pro Ile Thr Phe Ser Asn Ser Glu Met Asp His Ile Val Pro 
                565                 570                 575     


Arg Ala Gly Gln Gly Ser Thr Asn Thr Arg Glu Asn Leu Val Ala Val 
            580                 585                 590         


Cys His Arg Cys Asn Gln Ser Lys Gly Asn Thr Pro Phe Ala Ile Trp 
        595                 600                 605             


Ala Lys Asn Thr Ser Ile Glu Gly Val Ser Val Lys Glu Ala Val Glu 
    610                 615                 620                 


Arg Thr Arg His Trp Val Thr Asp Thr Gly Met Arg Ser Thr Asp Phe 
625                 630                 635                 640 


Lys Lys Phe Thr Lys Ala Val Val Glu Arg Phe Gln Arg Ala Thr Met 
                645                 650                 655     


Asp Glu Glu Ile Asp Ala Arg Ser Met Glu Ser Val Ala Trp Met Ala 
            660                 665                 670         


Asn Glu Leu Arg Ser Arg Val Ala Gln His Phe Ala Ser His Gly Thr 
        675                 680                 685             


Thr Val Arg Val Tyr Arg Gly Ser Leu Thr Ala Glu Ala Arg Arg Ala 
    690                 695                 700                 


Ser Gly Ile Ser Gly Lys Leu Glu Phe Leu Asp Gly Val Gly Lys Ser 
705                 710                 715                 720 


Arg Leu Asp Arg Arg His His Ala Ile Asp Ala Ala Val Ile Ala Phe 
                725                 730                 735     


Thr Ser Asp Tyr Val Ala Glu Thr Leu Ala Val Arg Ser Asn Leu Lys 
            740                 745                 750         


Gln Ser Gln Ala His Arg Gln Glu Ala Pro Gln Trp Arg Glu Phe Thr 
        755                 760                 765             


Gly Lys Asp Ala Glu His Arg Ala Ala Trp Arg Val Trp Cys Gln Lys 
    770                 775                 780                 


Met Glu Lys Leu Ser Ala Leu Leu Thr Glu Asp Leu Arg Asp Asp Arg 
785                 790                 795                 800 


Val Val Val Met Ser Asn Val Arg Leu Arg Leu Gly Asn Gly Ser Ala 
                805                 810                 815     


His Glu Glu Thr Ile Gly Lys Leu Ser Lys Val Lys Leu Gly Ser Gln 
            820                 825                 830         


Leu Ser Val Ser Asp Ile Asp Lys Ala Ser Ser Glu Ala Leu Trp Cys 
        835                 840                 845             


Ala Leu Thr Arg Glu Pro Asp Phe Asp Pro Lys Asp Gly Leu Pro Ala 
    850                 855                 860                 


Asn Pro Glu Arg His Ile Arg Val Asn Gly Thr His Val Tyr Ala Gly 
865                 870                 875                 880 


Asp Asn Ile Gly Leu Phe Pro Val Ser Ala Gly Ser Ile Ala Leu Arg 
                885                 890                 895     


Gly Gly Tyr Ala Glu Leu Gly Ser Ser Phe His His Ala Arg Val Tyr 
            900                 905                 910         


Lys Ile Thr Ser Gly Lys Lys Pro Ala Phe Ala Met Leu Arg Val Tyr 
        915                 920                 925             


Thr Ile Asp Leu Leu Pro Tyr Arg Asn Gln Asp Leu Phe Ser Val Glu 
    930                 935                 940                 


Leu Lys Pro Gln Thr Met Ser Met Arg Gln Ala Glu Lys Lys Leu Arg 
945                 950                 955                 960 


Asp Ala Leu Ala Thr Gly Asn Ala Glu Tyr Leu Gly Trp Leu Val Val 
                965                 970                 975     


Asp Asp Glu Leu Val Val Asp Thr Ser Lys Ile Ala Thr Asp Gln Val 
            980                 985                 990         


Lys Ala Val Glu Ala Glu Leu Gly  Thr Ile Arg Arg Trp  Arg Val Asp 
        995                 1000                 1005             


Gly Phe  Phe Gly Asp Thr Arg  Leu Arg Leu Arg Pro  Leu Gln Met 
    1010                 1015                 1020             


Ser Lys  Glu Gly Ile Lys Lys  Glu Leu Ala Pro Glu  Leu Ser Lys 
    1025                 1030                 1035             


Ile Ile  Asp Arg Pro Gly Trp  Leu Pro Ala Val Asn  Lys Leu Phe 
    1040                 1045                 1050             


Ser Glu  Gly Asn Val Thr Val  Val Arg Arg Asp Ser  Leu Gly Arg 
    1055                 1060                 1065             


Val Arg  Leu Glu Ser Thr Ala  His Leu Pro Val Thr  Trp Lys Val 
    1070                 1075                 1080             


Gln 
    


<210> 180
<211> 1089
<212> PRT
<213> Corynebacterium matruchotii


<220>
<223> Corynebacterium matruchotii ATCC 14266

<400> 180
Met Asn Ser Ala Asn Val Asn Tyr Arg Val Gly Ile Asp Val Gly Ser 
1               5                   10                  15      


Tyr Ser Leu Gly Met Ala Ala Ile Ala Ile Asp Asp Asp Gly Lys Pro 
            20                  25                  30          


Thr Glu Ile Leu Ser Ala Ile Ser Leu Ile His Asp Ser Gly Val Asp 
        35                  40                  45              


Pro Asp Ser Ala Lys Ser Ala Ala Thr Arg Leu Ala Thr Ser Gly Ile 
    50                  55                  60                  


Ala Arg Arg Thr Arg Arg Leu Tyr Arg Arg Lys Arg Lys Arg Leu Ala 
65                  70                  75                  80  


Lys Leu Asp Lys Phe Ile Ser Ser Gln Gly Trp Pro Leu Lys Glu Phe 
                85                  90                  95      


Glu Lys Tyr Glu Asp Pro Phe Tyr Pro Trp Arg Val Arg Ala Glu Leu 
            100                 105                 110         


Ala Thr Thr Ala Ile Thr Asp Gln Gln Glu Leu Gly Glu Lys Leu Ser 
        115                 120                 125             


Ile Ala Leu Arg His Ile Ala Arg His Arg Gly Trp Arg Asn Pro Tyr 
    130                 135                 140                 


Ser Lys Val Thr Ala Leu Tyr Thr Val Thr Glu Pro Ser Asp Ala Phe 
145                 150                 155                 160 


Leu Ala Met Gln Glu Glu Cys Ala Lys Gln Leu Gly Arg Thr Ile Pro 
                165                 170                 175     


Glu Thr Ile Thr Val Gly Gln Leu Val Thr Gly Met Asn Leu Gly Lys 
            180                 185                 190         


Thr Arg Leu Arg Gly Glu Asn Ser Leu Leu Ala Ala Arg Pro Arg Gln 
        195                 200                 205             


Ser Asp Asn Ala Asn Glu Ile His Thr Ile Ala Lys Val Gln Gly Leu 
    210                 215                 220                 


Ser Asn Glu Leu Val Arg Gln Ile Ile Asp His Val Phe Ala Ala Glu 
225                 230                 235                 240 


Ser Pro Lys Gly Ser Ala Ala Glu Gln Val Gly Lys Asp Pro Leu Gln 
                245                 250                 255     


Pro Thr Lys Lys Arg Ala Leu Lys Ala Ser Asp Ala Phe Gln Gln Tyr 
            260                 265                 270         


Arg Ile Ala Ala Leu Ile Gly Asn Leu Arg Ile Arg Gly Gly Lys Gly 
        275                 280                 285             


Asn Arg Arg Leu Thr Thr Glu Glu Thr Arg Leu Val Phe Asp Tyr Leu 
    290                 295                 300                 


Arg Ser Leu Pro Ala Lys Gln Glu Pro Thr Trp Gln Leu Val Ala Glu 
305                 310                 315                 320 


Gln Leu Lys Ile Asp Arg Gly Asn Leu Val Gly Thr Ala Ile Met Thr 
                325                 330                 335     


Asp Asp Gly Glu Arg Ala Gly Ala Lys Pro Pro Val His Asp Thr Asn 
            340                 345                 350         


Arg Ile Met Glu Asn Thr Lys Ile Lys Pro Leu Ala Thr Trp Trp Lys 
        355                 360                 365             


Ser Ala Asp Ala Asp Ala Arg Ala Ala Met Val Lys Ala Leu Ser Asn 
    370                 375                 380                 


Ala Glu Val Asp Asp Phe Asp Ser Gln Ala Gly Ala Gln Val Gln Glu 
385                 390                 395                 400 


Phe Phe Phe Gly Ile Ser Asp Glu Asp Gln Glu Lys Leu Asp Gly Leu 
                405                 410                 415     


His Leu Pro Ile Gly Arg Ala Ala Tyr Ser Glu Asp Thr Leu Asp Arg 
            420                 425                 430         


Leu Thr Lys Arg Met Ile Gly Glu Gly Met Asp Leu Tyr Glu Ala Arg 
        435                 440                 445             


Gln Ala Glu Phe Lys Ile Ser Asn Asp Trp Ala Pro Pro Ala Pro Glu 
    450                 455                 460                 


Ile Gly Glu Arg Val Gly Asn Pro Ala Val Asp Arg Val Leu Lys Ala 
465                 470                 475                 480 


Thr Ala Arg Trp Leu Asn Ala Ala Glu Arg Gln Trp Gly Ala Pro Lys 
                485                 490                 495     


Ser Val Asn Ile Glu His Val Arg Ala Ala Phe Met Ser Glu Ser Ser 
            500                 505                 510         


Ala Arg Glu Leu Asp Arg Asp Asn Gln Gln Arg Ala Lys Arg Asn Val 
        515                 520                 525             


Lys Val Val Ala Glu Met Gln Glu Lys Leu Gly Ile Glu Gly Arg Pro 
    530                 535                 540                 


Ser Arg Ala Asp Val Trp Arg Phe Gln Ser Ile Gln Arg Gln Asn Gly 
545                 550                 555                 560 


Lys Cys Ala Tyr Cys Gly Ala Glu Ile Ser Phe Lys Asn Ser Glu Met 
                565                 570                 575     


Asp His Ile Ile Pro Gln Ala Gly Glu Gly Ser Thr Asn Thr Arg Asp 
            580                 585                 590         


Asn Leu Val Ala Val Cys Arg Glu Cys Asn Ser Ser Lys Ser Asn Ile 
        595                 600                 605             


Ala Phe Ala Val Trp Ala Glu Asn Thr Ser Arg Pro Gly Val Ser Val 
    610                 615                 620                 


Gln Lys Ala Ile Glu Arg Thr His His Trp Val Thr Asp Ser Gly Leu 
625                 630                 635                 640 


Arg Lys Pro Glu Phe Asp Lys Phe Arg Lys Gln Val Cys Asp Arg Leu 
                645                 650                 655     


Arg Arg Lys Ala Thr Asp Glu Pro Ile Asp Ala Arg Ser Leu Glu Ser 
            660                 665                 670         


Val Ala Trp Met Ala Asn Glu Leu Arg Ser Arg Ile Ala Gln Lys Phe 
        675                 680                 685             


Lys Asp Gly Asp Thr Lys Val Arg Val Tyr Lys Gly Ala Leu Thr Ala 
    690                 695                 700                 


Glu Ala Arg Arg Ala Ser Gly Ile Ser Gly Lys Leu Glu Phe Val Asp 
705                 710                 715                 720 


Gly Lys Gly Lys Ser Arg Leu Asp Arg Arg His His Ala Val Asp Ala 
                725                 730                 735     


Ala Val Val Ala Phe Thr Ser Asn Tyr Val Ala Glu Thr Leu Ala Leu 
            740                 745                 750         


Arg Ser Asn Met Lys Phe Asp Gln Glu Leu Arg Arg Lys Ala Pro Gln 
        755                 760                 765             


Trp Arg Glu Phe Thr Gly Ser Asp His Val His Gln Val Glu Trp Thr 
    770                 775                 780                 


Lys Trp Lys Tyr Arg Met Gln Ala Leu Ala Glu Leu Leu Asn Asn Ala 
785                 790                 795                 800 


Leu Val Gln Asp Arg Ile Val Val Met His Asn Leu Arg Leu Arg Leu 
                805                 810                 815     


Gly Asn Gly Ala Ala His Glu Asp Thr Ile Gly Lys Leu Thr Arg Leu 
            820                 825                 830         


Lys Val Gly Asp Ala Ile Ser Thr Thr Asp Ile Asp Arg Ala Ser Ser 
        835                 840                 845             


Glu Ala Leu Trp Cys Ala Leu Thr Arg Asp Pro Asp Tyr Asp Pro Lys 
    850                 855                 860                 


Thr Gly Leu Pro Glu Asn Pro Asn Arg Thr Ile Arg Ile His Gly Thr 
865                 870                 875                 880 


His Leu Thr Ala Ser Asp Glu Ile Thr Val Phe Pro Val Ala Ala Ala 
                885                 890                 895     


Ser Ile Pro Ile Arg Asp Gly Phe Ala Lys Leu Gly Ser Asn Tyr His 
            900                 905                 910         


His Val Arg Leu Phe Arg Val Pro Ser Gly Lys Lys Tyr Lys Tyr Cys 
        915                 920                 925             


Leu Met Gln Val Tyr Thr Val Asp Leu Leu Lys Phe Arg Lys Glu Asp 
    930                 935                 940                 


Leu Phe Thr Val Glu Leu Lys Pro Gln Thr Ile Ser Val Arg Thr Cys 
945                 950                 955                 960 


Glu Ala Leu Leu Arg Lys Ala Leu Ala Asn Gly Thr Ala Glu Tyr Leu 
                965                 970                 975     


Gly Trp Leu Val Ser Asp Asp Glu Leu Leu Ile Asp Thr Ser Ser Phe 
            980                 985                 990         


Asp Thr Pro Gly Ile Val Lys Leu  Arg Glu Glu Tyr Gly  Pro Val Asn 
        995                 1000                 1005             


Arg Trp  Arg Leu Ala Gly Leu  Thr Ser Val Thr Arg  Leu Asn Leu 
    1010                 1015                 1020             


Arg Pro  Leu Tyr Leu Ser Lys  Glu Gly Leu Lys Pro  Asn Val Asn 
    1025                 1030                 1035             


Pro Glu  Ile Lys Lys Ile Ile  Asp Asn Arg Ser Trp  Ile Ile Thr 
    1040                 1045                 1050             


Val Asn  Lys Leu Phe Ser Ser  Gly His Val Lys Ile  Ile Arg Arg 
    1055                 1060                 1065             


Asp Ala  Leu Gly Arg Pro Arg  Leu His Ser Ala Ala  His Leu Pro 
    1070                 1075                 1080             


Ile Cys  Trp Glu Val Lys 
    1085                 


<210> 181
<211> 1069
<212> PRT
<213> Corynebacterium matruchotii


<220>
<223> Corynebacterium matruchotii ATCC 33806

<400> 181
Met Ala Ala Ile Ala Ile Asp Asp Asp Gly Lys Pro Thr Glu Ile Leu 
1               5                   10                  15      


Ser Ala Ile Ser Leu Ile His Asp Ser Gly Val Asp Pro Asp Ser Ala 
            20                  25                  30          


Lys Ser Ala Ala Thr Arg Leu Ala Thr Ser Gly Ile Ala Arg Arg Thr 
        35                  40                  45              


Arg Arg Leu Tyr Arg Arg Lys Arg Lys Arg Leu Ala Lys Leu Asp Lys 
    50                  55                  60                  


Phe Ile Ser Ser Gln Gly Trp Pro Leu Lys Glu Phe Glu Lys Tyr Glu 
65                  70                  75                  80  


Asp Pro Phe Tyr Pro Trp Arg Val Arg Ala Glu Leu Ala Thr Thr Ala 
                85                  90                  95      


Ile Thr Asp Gln Gln Glu Leu Gly Glu Lys Leu Ser Ile Ala Leu Arg 
            100                 105                 110         


His Ile Ala Arg His Arg Gly Trp Arg Asn Pro Tyr Ser Lys Val Thr 
        115                 120                 125             


Ala Leu Tyr Thr Val Thr Glu Pro Ser Asp Ala Phe Leu Ala Met Gln 
    130                 135                 140                 


Glu Glu Cys Ala Lys Gln Leu Gly Arg Thr Ile Pro Glu Thr Ile Thr 
145                 150                 155                 160 


Val Gly Gln Leu Val Thr Gly Met Asn Leu Gly Lys Thr Arg Leu Arg 
                165                 170                 175     


Gly Glu Asn Ser Leu Leu Ala Ala Arg Pro Arg Gln Ser Asp Asn Ala 
            180                 185                 190         


Asn Glu Ile His Thr Ile Ala Lys Val Gln Gly Leu Ser Asn Glu Leu 
        195                 200                 205             


Val Arg Gln Ile Ile Asp His Val Phe Ala Ala Glu Ser Pro Lys Gly 
    210                 215                 220                 


Ser Ala Ala Glu Gln Val Gly Lys Asp Pro Leu Gln Pro Thr Lys Lys 
225                 230                 235                 240 


Arg Ala Leu Lys Ala Ser Asp Ala Phe Gln Gln Tyr Arg Ile Ala Ala 
                245                 250                 255     


Leu Ile Gly Asn Leu Arg Ile Arg Gly Gly Lys Gly Asn Arg Arg Leu 
            260                 265                 270         


Thr Thr Glu Glu Thr Arg Leu Val Phe Asp Tyr Leu Arg Ser Leu Pro 
        275                 280                 285             


Ala Lys Gln Glu Pro Thr Trp Gln Leu Val Ala Glu Gln Leu Lys Ile 
    290                 295                 300                 


Asp Arg Gly Asn Leu Val Gly Thr Ala Ile Met Thr Asp Asp Gly Glu 
305                 310                 315                 320 


Arg Ala Gly Ala Lys Pro Pro Val His Asp Thr Asn Arg Ile Met Glu 
                325                 330                 335     


Asn Thr Lys Ile Lys Pro Leu Ala Thr Trp Trp Lys Ser Ala Asp Ala 
            340                 345                 350         


Asp Ala Arg Ala Ala Met Val Lys Ala Leu Ser Asn Ala Glu Val Asp 
        355                 360                 365             


Asp Phe Asp Ser Gln Ala Gly Ala Gln Val Gln Glu Phe Phe Phe Gly 
    370                 375                 380                 


Ile Ser Asp Glu Asp Gln Glu Lys Leu Asp Gly Leu His Leu Pro Ile 
385                 390                 395                 400 


Gly Arg Ala Ala Tyr Ser Glu Asp Thr Leu Asp Arg Leu Thr Lys Arg 
                405                 410                 415     


Met Ile Gly Glu Gly Met Asp Leu Tyr Glu Ala Arg Gln Ala Glu Phe 
            420                 425                 430         


Lys Ile Ser Asn Asp Trp Ala Pro Pro Ala Pro Glu Ile Gly Glu Arg 
        435                 440                 445             


Val Gly Asn Pro Ala Val Asp Arg Val Leu Lys Ala Thr Ala Arg Trp 
    450                 455                 460                 


Leu Asn Ala Ala Glu Arg Gln Trp Gly Ala Pro Lys Ser Val Asn Ile 
465                 470                 475                 480 


Glu His Val Arg Ala Ala Phe Met Ser Glu Ser Ser Ala Arg Glu Leu 
                485                 490                 495     


Asp Arg Asp Asn Gln Gln Arg Ala Lys Arg Asn Val Lys Val Val Ala 
            500                 505                 510         


Glu Met Gln Glu Lys Leu Gly Ile Glu Gly Arg Pro Ser Arg Ala Asp 
        515                 520                 525             


Val Trp Arg Phe Gln Ser Ile Gln Arg Gln Asn Gly Lys Cys Ala Tyr 
    530                 535                 540                 


Cys Gly Ala Glu Ile Ser Phe Lys Asn Ser Glu Met Asp His Ile Ile 
545                 550                 555                 560 


Pro Gln Val Gly Glu Gly Ser Thr Asn Thr Arg Asp Asn Leu Val Ala 
                565                 570                 575     


Val Cys Arg Glu Cys Asn Ser Ser Lys Ser Asn Ile Ala Phe Ala Val 
            580                 585                 590         


Trp Ala Glu Asn Thr Ser Arg Pro Gly Val Ser Val Gln Lys Ala Ile 
        595                 600                 605             


Glu Arg Thr His His Trp Val Thr Asp Ser Gly Leu Arg Lys Pro Glu 
    610                 615                 620                 


Phe Asp Lys Phe Arg Lys Gln Val Cys Asp Arg Leu Arg Arg Lys Ala 
625                 630                 635                 640 


Thr Asp Glu Pro Ile Asp Ala Arg Ser Leu Glu Ser Val Ala Trp Met 
                645                 650                 655     


Ala Asn Glu Leu Arg Ser Arg Ile Ala Gln Lys Phe Lys Asp Gly Asp 
            660                 665                 670         


Thr Lys Val Arg Val Tyr Lys Gly Ala Leu Thr Ala Glu Ala Arg Arg 
        675                 680                 685             


Ala Ser Gly Ile Ser Gly Lys Leu Glu Phe Val Asp Gly Lys Gly Lys 
    690                 695                 700                 


Ser Arg Leu Asp Arg Arg His His Ala Val Asp Ala Ala Val Val Ala 
705                 710                 715                 720 


Phe Thr Ser Asn Tyr Val Ala Glu Thr Leu Ala Leu Arg Ser Asn Met 
                725                 730                 735     


Lys Phe Asp Gln Glu Leu Arg Arg Lys Ala Pro Gln Trp Arg Glu Phe 
            740                 745                 750         


Thr Gly Ser Asp His Val His Gln Val Glu Trp Thr Lys Trp Lys Tyr 
        755                 760                 765             


Arg Met Gln Ala Leu Ala Glu Leu Leu Asn Asn Ala Leu Val Gln Asp 
    770                 775                 780                 


Arg Ile Val Val Met His Asn Leu Arg Leu Arg Leu Gly Asn Gly Ala 
785                 790                 795                 800 


Ala His Glu Asp Thr Ile Gly Lys Leu Thr Arg Leu Lys Val Gly Asp 
                805                 810                 815     


Ala Ile Ser Thr Thr Asp Ile Asp Arg Ala Ser Ser Glu Ala Leu Trp 
            820                 825                 830         


Cys Ala Leu Thr Arg Asp Pro Asp Tyr Asp Pro Lys Thr Gly Leu Pro 
        835                 840                 845             


Glu Asn Pro Asn Arg Thr Ile Arg Ile His Gly Thr His Leu Thr Ala 
    850                 855                 860                 


Ser Asp Glu Ile Thr Val Phe Pro Val Ala Ala Ala Ser Ile Pro Ile 
865                 870                 875                 880 


Arg Asp Gly Phe Ala Lys Leu Gly Ser Asn Tyr His His Val Arg Leu 
                885                 890                 895     


Phe Arg Val Pro Ser Gly Lys Lys Tyr Lys Tyr Cys Leu Met Gln Val 
            900                 905                 910         


Tyr Thr Val Asp Leu Leu Lys Phe Arg Lys Glu Asp Leu Phe Thr Val 
        915                 920                 925             


Glu Leu Lys Pro Gln Thr Ile Ser Val Arg Thr Cys Glu Ala Leu Leu 
    930                 935                 940                 


Arg Lys Ala Leu Ala Asn Gly Thr Ala Glu Tyr Leu Gly Trp Leu Val 
945                 950                 955                 960 


Ser Asp Asp Glu Leu Leu Ile Asp Thr Ser Ser Phe Asp Thr Pro Gly 
                965                 970                 975     


Ile Val Lys Leu Arg Glu Glu Tyr Gly Pro Val Asn Arg Trp Arg Leu 
            980                 985                 990         


Ala Gly Leu Thr Ser Val Thr Arg  Leu Asn Leu Arg Pro  Leu Tyr Leu 
        995                 1000                 1005             


Ser Lys  Glu Gly Leu Lys Pro  Asn Val Asn Pro Glu  Ile Lys Lys 
    1010                 1015                 1020             


Ile Ile  Asp Asn Arg Ser Trp  Ile Ile Thr Val Asn  Lys Leu Phe 
    1025                 1030                 1035             


Ser Ser  Gly His Val Lys Ile  Ile Arg Arg Asp Ala  Leu Gly Arg 
    1040                 1045                 1050             


Pro Arg  Leu His Ser Ala Ala  His Leu Pro Ile Cys  Trp Glu Val 
    1055                 1060                 1065             


Lys 
    


<210> 182
<211> 1079
<212> PRT
<213> Dinoroseobacter shibae

<400> 182
Met Arg Leu Gly Leu Asp Ile Gly Thr Ser Ser Ile Gly Trp Trp Leu 
1               5                   10                  15      


Tyr Glu Thr Asp Gly Ala Gly Ser Asp Ala Arg Ile Thr Gly Val Val 
            20                  25                  30          


Asp Gly Gly Val Arg Ile Phe Ser Asp Gly Arg Asp Pro Lys Ser Gly 
        35                  40                  45              


Ala Ser Leu Ala Val Asp Arg Arg Ala Ala Arg Ala Met Arg Arg Arg 
    50                  55                  60                  


Arg Asp Arg Tyr Leu Arg Arg Arg Ala Thr Leu Met Lys Val Leu Ala 
65                  70                  75                  80  


Glu Thr Gly Leu Met Pro Ala Asp Pro Ala Glu Ala Lys Ala Leu Glu 
                85                  90                  95      


Ala Leu Asp Pro Phe Ala Leu Arg Ala Ala Gly Leu Asp Glu Pro Leu 
            100                 105                 110         


Pro Leu Pro His Leu Gly Arg Ala Leu Phe His Leu Asn Gln Arg Arg 
        115                 120                 125             


Gly Phe Lys Ser Asn Arg Lys Thr Asp Arg Gly Asp Asn Glu Ser Gly 
    130                 135                 140                 


Lys Ile Lys Asp Ala Thr Ala Arg Leu Asp Met Glu Met Met Ala Asn 
145                 150                 155                 160 


Gly Ala Arg Thr Tyr Gly Glu Phe Leu His Lys Arg Arg Gln Lys Ala 
                165                 170                 175     


Thr Asp Pro Arg His Val Pro Ser Val Arg Thr Arg Leu Ser Ile Ala 
            180                 185                 190         


Asn Arg Gly Gly Pro Asp Gly Lys Glu Glu Ala Gly Tyr Asp Phe Tyr 
        195                 200                 205             


Pro Asp Arg Arg His Leu Glu Glu Glu Phe His Lys Leu Trp Ala Ala 
    210                 215                 220                 


Gln Gly Ala His His Pro Glu Leu Thr Glu Thr Leu Arg Asp Leu Leu 
225                 230                 235                 240 


Phe Glu Lys Ile Phe Phe Gln Arg Pro Leu Lys Glu Pro Glu Val Gly 
                245                 250                 255     


Leu Cys Leu Phe Ser Gly His His Gly Val Pro Pro Lys Asp Pro Arg 
            260                 265                 270         


Leu Pro Lys Ala His Pro Leu Thr Gln Arg Arg Val Leu Tyr Glu Thr 
        275                 280                 285             


Val Asn Gln Leu Arg Val Thr Ala Asp Gly Arg Glu Ala Arg Pro Leu 
    290                 295                 300                 


Thr Arg Glu Glu Arg Asp Gln Val Ile His Ala Leu Asp Asn Lys Lys 
305                 310                 315                 320 


Pro Thr Lys Ser Leu Ser Ser Met Val Leu Lys Leu Pro Ala Leu Ala 
                325                 330                 335     


Lys Val Leu Lys Leu Arg Asp Gly Glu Arg Phe Thr Leu Glu Thr Gly 
            340                 345                 350         


Val Arg Asp Ala Ile Ala Cys Asp Pro Leu Arg Ala Ser Pro Ala His 
        355                 360                 365             


Pro Asp Arg Phe Gly Pro Arg Trp Ser Ile Leu Asp Ala Asp Ala Gln 
    370                 375                 380                 


Trp Glu Val Ile Ser Arg Ile Arg Arg Val Gln Ser Asp Ala Glu His 
385                 390                 395                 400 


Ala Ala Leu Val Asp Trp Leu Thr Glu Ala His Gly Leu Asp Arg Ala 
                405                 410                 415     


His Ala Glu Ala Thr Ala His Ala Pro Leu Pro Asp Gly Tyr Gly Arg 
            420                 425                 430         


Leu Gly Leu Thr Ala Thr Thr Arg Ile Leu Tyr Gln Leu Thr Ala Asp 
        435                 440                 445             


Val Val Thr Tyr Ala Asp Ala Val Lys Ala Cys Gly Trp His His Ser 
    450                 455                 460                 


Asp Gly Arg Thr Gly Glu Cys Phe Asp Arg Leu Pro Tyr Tyr Gly Glu 
465                 470                 475                 480 


Val Leu Glu Arg His Val Ile Pro Gly Ser Tyr His Pro Asp Asp Asp 
                485                 490                 495     


Asp Ile Thr Arg Phe Gly Arg Ile Thr Asn Pro Thr Val His Ile Gly 
            500                 505                 510         


Leu Asn Gln Leu Arg Arg Leu Val Asn Arg Ile Ile Glu Thr His Gly 
        515                 520                 525             


Lys Pro His Gln Ile Val Val Glu Leu Ala Arg Asp Leu Lys Lys Ser 
    530                 535                 540                 


Glu Glu Gln Lys Arg Ala Asp Ile Lys Arg Ile Arg Asp Thr Thr Glu 
545                 550                 555                 560 


Ala Ala Lys Lys Arg Ser Glu Lys Leu Glu Glu Leu Glu Ile Glu Asp 
                565                 570                 575     


Asn Gly Arg Asn Arg Met Leu Leu Arg Leu Trp Glu Asp Leu Asn Pro 
            580                 585                 590         


Asp Asp Ala Met Arg Arg Phe Cys Pro Tyr Thr Gly Thr Arg Ile Ser 
        595                 600                 605             


Ala Ala Met Ile Phe Asp Gly Ser Cys Asp Val Asp His Ile Leu Pro 
    610                 615                 620                 


Tyr Ser Arg Thr Leu Asp Asp Ser Phe Pro Asn Arg Thr Leu Cys Leu 
625                 630                 635                 640 


Arg Glu Ala Asn Arg Gln Lys Arg Asn Gln Thr Pro Trp Gln Ala Trp 
                645                 650                 655     


Gly Asp Thr Pro His Trp His Ala Ile Ala Ala Asn Leu Lys Asn Leu 
            660                 665                 670         


Pro Glu Asn Lys Arg Trp Arg Phe Ala Pro Asp Ala Met Thr Arg Phe 
        675                 680                 685             


Glu Gly Glu Asn Gly Phe Leu Asp Arg Ala Leu Lys Asp Thr Gln Tyr 
    690                 695                 700                 


Leu Ala Arg Ile Ser Arg Ser Tyr Leu Asp Thr Leu Phe Thr Lys Gly 
705                 710                 715                 720 


Gly His Val Trp Val Val Pro Gly Arg Phe Thr Glu Met Leu Arg Arg 
                725                 730                 735     


His Trp Gly Leu Asn Ser Leu Leu Ser Asp Ala Gly Arg Gly Ala Val 
            740                 745                 750         


Lys Ala Lys Asn Arg Thr Asp His Arg His His Ala Ile Asp Ala Ala 
        755                 760                 765             


Val Ile Ala Ala Thr Asp Pro Gly Leu Leu Asn Arg Ile Ser Arg Ala 
    770                 775                 780                 


Ala Gly Gln Gly Glu Ala Ala Gly Gln Ser Ala Glu Leu Ile Ala Arg 
785                 790                 795                 800 


Asp Thr Pro Pro Pro Trp Glu Gly Phe Arg Asp Asp Leu Arg Val Arg 
                805                 810                 815     


Leu Asp Arg Ile Ile Val Ser His Arg Ala Asp His Gly Arg Ile Asp 
            820                 825                 830         


His Ala Ala Arg Lys Gln Gly Arg Asp Ser Thr Ala Gly Gln Leu His 
        835                 840                 845             


Gln Glu Thr Ala Tyr Ser Ile Val Asp Asp Ile His Val Ala Ser Arg 
    850                 855                 860                 


Thr Asp Leu Leu Ser Leu Lys Pro Ala Gln Leu Leu Asp Glu Pro Gly 
865                 870                 875                 880 


Arg Ser Gly Gln Val Arg Asp Pro Gln Leu Arg Lys Ala Leu Arg Val 
                885                 890                 895     


Ala Thr Gly Gly Lys Thr Gly Lys Asp Phe Glu Asn Ala Leu Arg Tyr 
            900                 905                 910         


Phe Ala Ser Lys Pro Gly Pro Tyr Gln Ala Ile Arg Arg Val Arg Ile 
        915                 920                 925             


Ile Lys Pro Leu Gln Ala Gln Ala Arg Val Pro Val Pro Ala Gln Asp 
    930                 935                 940                 


Pro Ile Lys Ala Tyr Gln Gly Gly Ser Asn His Leu Phe Glu Ile Trp 
945                 950                 955                 960 


Arg Leu Pro Asp Gly Glu Ile Glu Ala Gln Val Ile Thr Ser Phe Glu 
                965                 970                 975     


Ala His Thr Leu Glu Gly Glu Lys Arg Pro His Pro Ala Ala Lys Arg 
            980                 985                 990         


Leu Leu Arg Val His Lys Gly Asp  Met Val Ala Leu Glu  Arg Asp Gly 
        995                 1000                 1005             


Arg Arg  Val Val Gly His Val  Gln Lys Met Asp Ile  Ala Asn Gly 
    1010                 1015                 1020             


Leu Phe  Ile Val Pro His Asn  Glu Ala Asn Ala Asp  Thr Arg Asn 
    1025                 1030                 1035             


Asn Asp  Lys Ser Asp Pro Phe  Lys Trp Ile Gln Ile  Gly Ala Arg 
    1040                 1045                 1050             


Pro Ala  Ile Ala Ser Gly Ile  Arg Arg Val Ser Val  Asp Glu Ile 
    1055                 1060                 1065             


Gly Arg  Leu Arg Asp Gly Gly  Thr Arg Pro Ile 
    1070                 1075                 


<210> 183
<211> 1332
<212> PRT
<213> Dolosigranulum pigrum


<220>
<223> Dolosigranulum pigrum ATCC 51524

<400> 183
Met Gln Lys Asn Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Met Lys Asp Asp Tyr Thr Leu Ile Arg Lys Arg Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Ile Lys Lys Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Glu Gly Glu Thr Ala Lys Glu Thr Arg Leu 
    50                  55                  60                  


Lys Arg Gly Thr Arg Arg Arg Tyr Gln Arg Arg Arg Asn Arg Leu Ile 
65                  70                  75                  80  


Tyr Leu Gln Asp Ile Phe Gln Gln Pro Met Leu Ala Ile Asp Glu Asn 
                85                  90                  95      


Phe Phe His Arg Leu Asp Asp Ser Phe Phe Val Pro Asp Asp Lys Ser 
            100                 105                 110         


Tyr Asp Arg His Pro Ile Phe Gly Ser Leu Glu Glu Glu Val Ala Tyr 
        115                 120                 125             


His Asn Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Ala Asp Leu Arg Leu Val Tyr Thr Ala Leu Ala His 
145                 150                 155                 160 


Ile Val Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Thr 
                165                 170                 175     


Glu Asn Thr Ser Ile Ser Glu Thr Phe Glu Gln Phe Leu Asp Thr Tyr 
            180                 185                 190         


Ser Asp Ile Phe Lys Glu Gln Leu Val Gly Asp Ile Ser Lys Val Glu 
        195                 200                 205             


Glu Ile Leu Ser Ser Lys Gln Ser Arg Ser Arg Lys His Glu Gln Ile 
    210                 215                 220                 


Met Ala Leu Phe Pro Asn Glu Asn Lys Leu Gly Asn Phe Gly Arg Phe 
225                 230                 235                 240 


Met Met Leu Ile Val Gly Asn Thr Ser Asn Phe Lys Pro Val Phe Asp 
                245                 250                 255     


Leu Asp Asp Glu Tyr Lys Leu Lys Leu Ser Asp Glu Thr Tyr Glu Glu 
            260                 265                 270         


Asp Leu Asp Thr Leu Leu Gly Met Thr Asp Asp Val Phe Leu Asp Val 
        275                 280                 285             


Phe Met Ala Ala Lys Asn Val Tyr Asp Ala Val Glu Met Ser Ala Ile 
    290                 295                 300                 


Ile Ser Thr Asp Thr Gly Asn Ser Lys Ala Val Leu Ser Asn Gln Met 
305                 310                 315                 320 


Ile Asn Phe Tyr Asp Glu His Lys Val Asp Leu Ala Gln Leu Lys Gln 
                325                 330                 335     


Phe Phe Lys Thr His Leu Pro Asp Lys Tyr Tyr Glu Cys Phe Ser Asp 
            340                 345                 350         


Pro Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn Gln 
        355                 360                 365             


Glu Asp Phe Tyr Lys Tyr Ile Glu Lys Val Met Lys Thr Ile Lys Ser 
    370                 375                 380                 


Asp Lys Lys Asp Tyr Phe Leu Asp Lys Ile Asp Arg Glu Val Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Ser Phe Tyr Asn Ser Val Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met Gln Ala Ile Leu Asp Arg Gln Ser Gln Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Ala Glu Asn Arg Asp Lys Ile Glu Ser Leu Val Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Thr Val Ser Asp Gln Ser Glu Phe 
    450                 455                 460                 


Ala Trp Met Glu Arg Gln Ser Asp Glu Pro Ile Arg Pro Trp Asn Phe 
465                 470                 475                 480 


Asp Glu Ile Val Asn Lys Glu Arg Ser Ala Glu Lys Phe Ile Glu Arg 
                485                 490                 495     


Met Thr Asn Met Asp Thr Tyr Leu Leu Glu Glu Lys Val Leu Pro Lys 
            500                 505                 510         


Arg Ser Leu Leu Tyr Gln Thr Phe Glu Val Tyr Asn Glu Leu Thr Lys 
        515                 520                 525             


Val Arg Tyr Thr Asn Glu Gln Gly Lys Thr Glu Lys Leu Asn Arg Gln 
    530                 535                 540                 


Gln Lys Ala Glu Ile Ile Glu Thr Leu Phe Lys Gln Lys Asn Arg Val 
545                 550                 555                 560 


Arg Glu Lys Asp Ile Ala Asn Tyr Leu Glu Gln Tyr Gly Tyr Val Asp 
                565                 570                 575     


Gly Thr Asp Ile Lys Gly Val Glu Asp Lys Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr Asn Asp Leu Ala Lys Ile Asp Gly Ala Lys Ala Tyr Leu Asp 
        595                 600                 605             


Asp Pro Glu Tyr Ala Asp Val Trp Glu Asp Ile Ile Lys Ile Leu Thr 
    610                 615                 620                 


Ile Phe Glu Asp Lys Ala Met Arg Lys Lys Gln Leu Gln Thr Tyr Ser 
625                 630                 635                 640 


Asp Thr Leu Ser Pro Glu Ile Leu Lys Lys Leu Glu Arg Lys His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Phe Ser Lys Lys Leu Ile Asn Gly Leu Arg Asp 
            660                 665                 670         


Glu Gly Ser Asn Lys Thr Ile Leu Asp Tyr Leu Lys Ser Asp Glu Gly 
        675                 680                 685             


Ser Ser Gly Pro Thr Asn Arg Asn Phe Met Gln Leu Ile Arg Asp Asn 
    690                 695                 700                 


Thr Leu Ser Phe Lys Lys Lys Ile Glu Asp Ala Gln Thr Ile Glu Asp 
705                 710                 715                 720 


Thr Thr His Ile Tyr Asp Thr Val Ala Glu Leu Pro Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Arg Gln Ala Leu Lys Ile Val Glu Glu Ile Ile 
            740                 745                 750         


Asp Ile Ile Gly Tyr Glu Pro Glu Asn Ile Val Val Glu Met Ala Arg 
        755                 760                 765             


Glu Ser Gln Thr Thr Lys Lys Gly Lys Asp Leu Ser Lys Glu Arg Leu 
    770                 775                 780                 


Glu Lys Leu Thr Glu Ala Ile Lys Glu Phe Asp Gly Pro Ser Asp Val 
785                 790                 795                 800 


Lys Val Lys Asp Leu Lys Asn Glu Asn Leu Arg Asn Asp Arg Leu Tyr 
                805                 810                 815     


Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Asn Glu Pro Leu 
            820                 825                 830         


Asp Ile Asn Asn Leu Ser Lys Tyr Asp Ile Asp His Ile Ile Pro Gln 
        835                 840                 845             


Ser Phe Thr Thr Asp Asn Ser Ile Asp Asn Lys Val Leu Val Ser Arg 
    850                 855                 860                 


Thr Lys Asn Gln Gly Asn Lys Ser Asp Asp Val Pro Ser Ile Asn Ile 
865                 870                 875                 880 


Val His Lys Met Lys Pro Phe Trp Arg Gln Leu His Lys Ala Gly Leu 
                885                 890                 895     


Ile Ser Asp Arg Lys Phe Lys Asn Leu Thr Lys Ala Glu His Gly Gly 
            900                 905                 910         


Leu Thr Glu Ala Asp Arg Ala His Phe Leu Asn Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Asn Leu Leu Asp Ser Gln Tyr 
    930                 935                 940                 


Asn Thr Ala Glu Glu Gln Arg Ile Asn Ile Val Leu Leu Lys Ser Ser 
945                 950                 955                 960 


Met Thr Ser Arg Phe Arg Lys Glu Phe Lys Leu Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asp Tyr His His Gly His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Ala Thr Thr Ile Met Lys Val Tyr  Pro Asn Leu Lys Pro  Gln Phe Val 
        995                 1000                 1005             


Tyr Gly  Gln Tyr Lys Lys Thr  Ser Met Phe Lys Glu  Glu Lys Ala 
    1010                 1015                 1020             


Thr Ala  Arg Lys His Phe Tyr  Ser Asn Ile Thr Lys  Phe Phe Lys 
    1025                 1030                 1035             


Lys Glu  Lys Val Val Asn Glu  Glu Thr Gly Glu Ile  Leu Trp Asp 
    1040                 1045                 1050             


Thr Glu  Arg His Leu Ser Thr  Ile Lys Arg Val Leu  Ser Trp Lys 
    1055                 1060                 1065             


Gln Met  Asn Ile Val Lys Lys  Val Glu Lys Gln Lys  Gly Gln Leu 
    1070                 1075                 1080             


Trp Lys  Glu Thr Ile Tyr Pro  Lys Gly Asp Ser Ser  Lys Leu Ile 
    1085                 1090                 1095             


Pro Val  Lys Glu Gly Met Asp  Pro Gln Lys Tyr Gly  Gly Leu Ser 
    1100                 1105                 1110             


Gln Val  Ser Glu Ala Phe Ala  Val Val Ile Thr His  Glu Lys Gly 
    1115                 1120                 1125             


Lys Lys  Lys Gln Leu Lys Ser  Asp Leu Ile Ser Ile  Pro Ile Val 
    1130                 1135                 1140             


Asp Gln  Lys Ala Tyr Glu Gln  His Pro Thr Ala Tyr  Leu Glu Glu 
    1145                 1150                 1155             


Ala Gly  Tyr Asn Asn Pro Thr  Val Leu His Glu Leu  Phe Lys Tyr 
    1160                 1165                 1170             


Gln Leu  Phe Glu Leu Glu Asp  Gly Ser Arg Arg Met  Ile Ala Ser 
    1175                 1180                 1185             


Ala Lys  Glu Phe Gln Lys Gly  Asn Gln Met Val Leu  Pro Leu Glu 
    1190                 1195                 1200             


Leu Val  Glu Leu Leu Tyr His  Ala Asn Arg Tyr Asp  Lys Val Lys 
    1205                 1210                 1215             


Phe Pro  Asp Ser Ile Glu Tyr  Val His Asp Asn Leu  Ala Lys Phe 
    1220                 1225                 1230             


Asp Asp  Leu Leu Glu Tyr Val  Ile Asp Phe Ser Asn  Lys Tyr Ile 
    1235                 1240                 1245             


Asn Ala  Asp Lys Asn Val Gln  Lys Ile Gln Lys Ile  Tyr Lys Glu 
    1250                 1255                 1260             


His Gly  Thr Glu Asp Val Glu  Leu Thr Val Glu Ser  Phe Val Asn 
    1265                 1270                 1275             


Leu Met  Thr Phe Thr Ala Met  Gly Ala Pro Ala Thr  Phe Lys Phe 
    1280                 1285                 1290             


Tyr Gly  Glu Ser Ile Thr Arg  Ser Arg Tyr Thr Ser  Ile Thr Glu 
    1295                 1300                 1305             


Phe Arg  Gly Ser Thr Leu Ile  Phe Gln Ser Ile Thr  Gly Leu Tyr 
    1310                 1315                 1320             


Glu Thr  Arg Tyr Lys Leu Glu  Asp Asn 
    1325                 1330         


<210> 184
<211> 1340
<212> PRT
<213> Dorea longicatena


<220>
<223> Dorea longicatena DSM 13814

<400> 184
Met Glu Gln Glu Tyr Tyr Leu Gly Leu Asp Met Gly Thr Gly Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Thr Asp Ser Glu Tyr His Val Leu Arg Lys His Gly 
            20                  25                  30          


Lys Ala Leu Trp Gly Val Arg Leu Phe Glu Ser Ala Ser Thr Ala Glu 
        35                  40                  45              


Glu Arg Arg Met Phe Arg Thr Ser Arg Arg Arg Leu Asp Arg Arg Asn 
    50                  55                  60                  


Trp Arg Ile Glu Ile Leu Gln Glu Ile Phe Ala Glu Glu Ile Ser Lys 
65                  70                  75                  80  


Lys Asp Pro Gly Phe Phe Leu Arg Met Lys Glu Ser Lys Tyr Tyr Pro 
                85                  90                  95      


Glu Asp Lys Arg Asp Ile Asn Gly Asn Cys Pro Glu Leu Pro Tyr Ala 
            100                 105                 110         


Leu Phe Val Asp Asp Asp Phe Thr Asp Lys Asp Tyr His Lys Lys Phe 
        115                 120                 125             


Pro Thr Ile Tyr His Leu Arg Lys Met Leu Met Asn Thr Glu Glu Thr 
    130                 135                 140                 


Pro Asp Ile Arg Leu Val Tyr Leu Ala Ile His His Met Met Lys His 
145                 150                 155                 160 


Arg Gly His Phe Leu Leu Ser Gly Asp Ile Asn Glu Ile Lys Glu Phe 
                165                 170                 175     


Gly Thr Thr Phe Ser Lys Leu Leu Glu Asn Ile Lys Asn Glu Glu Leu 
            180                 185                 190         


Asp Trp Asn Leu Glu Leu Gly Lys Glu Glu Tyr Ala Val Val Glu Ser 
        195                 200                 205             


Ile Leu Lys Asp Asn Met Leu Asn Arg Ser Thr Lys Lys Thr Arg Leu 
    210                 215                 220                 


Ile Lys Ala Leu Lys Ala Lys Ser Ile Cys Glu Lys Ala Val Leu Asn 
225                 230                 235                 240 


Leu Leu Ala Gly Gly Thr Val Lys Leu Ser Asp Ile Phe Gly Leu Glu 
                245                 250                 255     


Glu Leu Asn Glu Thr Glu Arg Pro Lys Ile Ser Phe Ala Asp Asn Gly 
            260                 265                 270         


Tyr Asp Asp Tyr Ile Gly Glu Val Glu Asn Glu Leu Gly Glu Gln Phe 
        275                 280                 285             


Tyr Ile Ile Glu Thr Ala Lys Ala Val Tyr Asp Trp Ala Val Leu Val 
    290                 295                 300                 


Glu Ile Leu Gly Lys Tyr Thr Ser Ile Ser Glu Ala Lys Val Ala Thr 
305                 310                 315                 320 


Tyr Glu Lys His Lys Ser Asp Leu Gln Phe Leu Lys Lys Ile Val Arg 
                325                 330                 335     


Lys Tyr Leu Thr Lys Glu Glu Tyr Lys Asp Ile Phe Val Ser Thr Ser 
            340                 345                 350         


Asp Lys Leu Lys Asn Tyr Ser Ala Tyr Ile Gly Met Thr Lys Ile Asn 
        355                 360                 365             


Gly Lys Lys Val Asp Leu Gln Ser Lys Arg Cys Ser Lys Glu Glu Phe 
    370                 375                 380                 


Tyr Asp Phe Ile Lys Lys Asn Val Leu Lys Lys Leu Glu Gly Gln Pro 
385                 390                 395                 400 


Glu Tyr Glu Tyr Leu Lys Glu Glu Leu Glu Arg Glu Thr Phe Leu Pro 
                405                 410                 415     


Lys Gln Val Asn Arg Asp Asn Gly Val Ile Pro Tyr Gln Ile His Leu 
            420                 425                 430         


Tyr Glu Leu Lys Lys Ile Leu Gly Asn Leu Arg Asp Lys Ile Asp Leu 
        435                 440                 445             


Ile Lys Glu Asn Glu Asp Lys Leu Val Gln Leu Phe Glu Phe Arg Ile 
    450                 455                 460                 


Pro Tyr Tyr Val Gly Pro Leu Asn Lys Ile Asp Asp Gly Lys Glu Gly 
465                 470                 475                 480 


Lys Phe Thr Trp Ala Val Arg Lys Ser Asn Glu Lys Ile Tyr Pro Trp 
                485                 490                 495     


Asn Phe Glu Asn Val Val Asp Ile Glu Ala Ser Ala Glu Lys Phe Ile 
            500                 505                 510         


Arg Arg Met Thr Asn Lys Cys Thr Tyr Leu Met Gly Glu Asp Val Leu 
        515                 520                 525             


Pro Lys Asp Ser Leu Leu Tyr Ser Lys Tyr Met Val Leu Asn Glu Leu 
    530                 535                 540                 


Asn Asn Val Lys Leu Asp Gly Glu Lys Leu Ser Val Glu Leu Lys Gln 
545                 550                 555                 560 


Arg Leu Tyr Thr Asp Val Phe Cys Lys Tyr Arg Lys Val Thr Val Lys 
                565                 570                 575     


Lys Ile Lys Asn Tyr Leu Lys Cys Glu Gly Ile Ile Ser Gly Asn Val 
            580                 585                 590         


Glu Ile Thr Gly Ile Asp Gly Asp Phe Lys Ala Ser Leu Thr Ala Tyr 
        595                 600                 605             


His Asp Phe Lys Glu Ile Leu Thr Gly Thr Glu Leu Ala Lys Lys Asp 
    610                 615                 620                 


Lys Glu Asn Ile Ile Thr Asn Ile Val Leu Phe Gly Asp Asp Lys Lys 
625                 630                 635                 640 


Leu Leu Lys Lys Arg Leu Asn Arg Leu Tyr Pro Gln Ile Thr Pro Asn 
                645                 650                 655     


Gln Leu Lys Lys Ile Cys Ala Leu Ser Tyr Thr Gly Trp Gly Arg Phe 
            660                 665                 670         


Ser Lys Lys Phe Leu Glu Glu Ile Thr Ala Pro Asp Pro Glu Thr Gly 
        675                 680                 685             


Glu Val Trp Asn Ile Ile Thr Ala Leu Trp Glu Ser Asn Asn Asn Leu 
    690                 695                 700                 


Met Gln Leu Leu Ser Asn Glu Tyr Arg Phe Met Glu Glu Val Glu Thr 
705                 710                 715                 720 


Tyr Asn Met Gly Lys Gln Thr Lys Thr Leu Ser Tyr Glu Thr Val Glu 
                725                 730                 735     


Asn Met Tyr Val Ser Pro Ser Val Lys Arg Gln Ile Trp Gln Thr Leu 
            740                 745                 750         


Lys Ile Val Lys Glu Leu Glu Lys Val Met Lys Glu Ser Pro Lys Arg 
        755                 760                 765             


Val Phe Ile Glu Met Ala Arg Glu Lys Gln Glu Ser Lys Arg Thr Glu 
    770                 775                 780                 


Ser Arg Lys Lys Gln Leu Ile Asp Leu Tyr Lys Ala Cys Lys Asn Glu 
785                 790                 795                 800 


Glu Lys Asp Trp Val Lys Glu Leu Gly Asp Gln Glu Glu Gln Lys Leu 
                805                 810                 815     


Arg Ser Asp Lys Leu Tyr Leu Tyr Tyr Thr Gln Lys Gly Arg Cys Met 
            820                 825                 830         


Tyr Ser Gly Glu Val Ile Glu Leu Lys Asp Leu Trp Asp Asn Thr Lys 
        835                 840                 845             


Tyr Asp Ile Asp His Ile Tyr Pro Gln Ser Lys Thr Met Asp Asp Ser 
    850                 855                 860                 


Leu Asn Asn Arg Val Leu Val Lys Lys Lys Tyr Asn Ala Thr Lys Ser 
865                 870                 875                 880 


Asp Lys Tyr Pro Leu Asn Glu Asn Ile Arg His Glu Arg Lys Gly Phe 
                885                 890                 895     


Trp Lys Ser Leu Leu Asp Gly Gly Phe Ile Ser Lys Glu Lys Tyr Glu 
            900                 905                 910         


Arg Leu Ile Arg Asn Thr Glu Leu Ser Pro Glu Glu Leu Ala Gly Phe 
        915                 920                 925             


Ile Glu Arg Gln Ile Val Glu Thr Arg Gln Ser Thr Lys Ala Val Ala 
    930                 935                 940                 


Glu Ile Leu Lys Gln Val Phe Pro Glu Ser Glu Ile Val Tyr Val Lys 
945                 950                 955                 960 


Ala Gly Thr Val Ser Arg Phe Arg Lys Asp Phe Glu Leu Leu Lys Val 
                965                 970                 975     


Arg Glu Val Asn Asp Leu His His Ala Lys Asp Ala Tyr Leu Asn Ile 
            980                 985                 990         


Val Val Gly Asn Ser Tyr Tyr Val  Lys Phe Thr Lys Asn  Ala Ser Trp 
        995                 1000                 1005             


Phe Ile  Lys Glu Asn Pro Gly  Arg Thr Tyr Asn Leu  Lys Lys Met 
    1010                 1015                 1020             


Phe Thr  Ser Gly Trp Asn Ile  Glu Arg Asn Gly Glu  Val Ala Trp 
    1025                 1030                 1035             


Glu Val  Gly Lys Lys Gly Thr  Ile Val Thr Val Lys  Gln Ile Met 
    1040                 1045                 1050             


Asn Lys  Asn Asn Ile Leu Val  Thr Arg Gln Val His  Glu Ala Lys 
    1055                 1060                 1065             


Gly Gly  Leu Phe Asp Gln Gln  Ile Met Lys Lys Gly  Lys Gly Gln 
    1070                 1075                 1080             


Ile Ala  Ile Lys Glu Thr Asp  Glu Arg Leu Ala Ser  Ile Glu Lys 
    1085                 1090                 1095             


Tyr Gly  Gly Tyr Asn Lys Ala  Ala Gly Ala Tyr Phe  Met Leu Val 
    1100                 1105                 1110             


Glu Ser  Lys Asp Lys Lys Gly  Lys Thr Ile Arg Thr  Ile Glu Phe 
    1115                 1120                 1125             


Ile Pro  Leu Tyr Leu Lys Asn  Lys Ile Glu Ser Asp  Glu Ser Ile 
    1130                 1135                 1140             


Ala Leu  Asn Phe Leu Glu Lys  Gly Arg Gly Leu Lys  Glu Pro Lys 
    1145                 1150                 1155             


Ile Leu  Leu Lys Lys Ile Lys  Ile Asp Thr Leu Phe  Asp Val Asp 
    1160                 1165                 1170             


Gly Phe  Lys Met Trp Leu Ser  Gly Arg Thr Gly Asp  Arg Leu Leu 
    1175                 1180                 1185             


Phe Lys  Cys Ala Asn Gln Leu  Ile Leu Asp Glu Lys  Ile Ile Val 
    1190                 1195                 1200             


Thr Met  Lys Lys Ile Val Lys  Phe Ile Gln Arg Arg  Gln Glu Asn 
    1205                 1210                 1215             


Arg Glu  Leu Lys Leu Ser Asp  Lys Asp Gly Ile Asp  Asn Glu Val 
    1220                 1225                 1230             


Leu Met  Glu Ile Tyr Asn Thr  Phe Val Asp Lys Leu  Glu Asn Thr 
    1235                 1240                 1245             


Val Tyr  Arg Ile Arg Leu Ser  Glu Gln Ala Lys Thr  Leu Ile Asp 
    1250                 1255                 1260             


Lys Gln  Lys Glu Phe Glu Arg  Leu Ser Leu Glu Asp  Lys Ser Ser 
    1265                 1270                 1275             


Thr Leu  Phe Glu Ile Leu His  Ile Phe Gln Cys Gln  Ser Ser Ala 
    1280                 1285                 1290             


Ala Asn  Leu Lys Met Ile Gly  Gly Pro Gly Lys Ala  Gly Ile Leu 
    1295                 1300                 1305             


Val Met  Asn Asn Asn Ile Ser  Lys Cys Asn Lys Ile  Ser Ile Ile 
    1310                 1315                 1320             


Asn Gln  Ser Pro Thr Gly Ile  Phe Glu Asn Glu Ile  Asp Leu Leu 
    1325                 1330                 1335             


Lys Ile  
    1340 


<210> 185
<211> 1380
<212> PRT
<213> Eggerthella sp.


<220>
<223> Eggerthella sp. YY7918

<400> 185
Met Asn Leu Arg His Val Gly Asn Tyr Asn Ile Gly Leu Asp Met Gly 
1               5                   10                  15      


Thr Ala Ser Val Gly Trp Ala Ala Ile Asp Glu Gln Gly Glu Leu Leu 
            20                  25                  30          


His Phe Lys Gly Lys Pro Thr Trp Gly Ser Arg Leu Phe Asp Ser Ala 
        35                  40                  45              


Asn Thr Ala Ala Thr Ala Arg Met Pro Arg Gly Gln Arg Arg Arg Tyr 
    50                  55                  60                  


Ile Arg Arg Arg Trp Arg Leu Asp Leu Leu Gln Lys Phe Phe Ser Glu 
65                  70                  75                  80  


Glu Met Ala Glu Lys Asp Pro Glu Phe Phe Ile Arg Leu Arg Gln Ser 
                85                  90                  95      


Ser Leu Trp Pro Glu Asp Arg Glu Gly Gly His Thr Ala Tyr His Trp 
            100                 105                 110         


Pro Leu Phe Asn Asp Ser Asp Phe Asn Glu Lys Glu Tyr Tyr Glu Lys 
        115                 120                 125             


Phe Pro Thr Ile Phe His Leu Arg Gln Trp Leu Met Glu Thr Asp Glu 
    130                 135                 140                 


Lys Ala Asp Ile Arg Leu Ile Tyr Leu Ala Phe His Asn Ile Val Lys 
145                 150                 155                 160 


His Arg Gly Asn Phe Leu Gln Glu Asn Asn Asp Ser Leu Ser Ala Gln 
                165                 170                 175     


Asn Ala Asn Met Arg Glu Ser Leu Glu Ser Phe Cys Ile Ala Leu Glu 
            180                 185                 190         


Glu Trp Cys Asp Glu Lys Glu Leu Thr Cys Ser Cys Asp Pro Gln Lys 
        195                 200                 205             


Leu Glu His Leu Phe Lys Glu Val Lys Tyr Arg Ser Asp Ile Arg Asp 
    210                 215                 220                 


Gly Phe Ala Ala Leu Leu Gly Leu Ala Cys Ser Gly Glu Asn Glu Val 
225                 230                 235                 240 


Asp Val Lys Ala Met Ala Lys Glu Met Gly Lys Ala Ile Val Gly Tyr 
                245                 250                 255     


Lys Ala Asp Phe Ser Lys Ile Phe Thr Glu Cys Asp Lys Glu Gly Ser 
            260                 265                 270         


Ser Phe Arg Leu Ser Asp Asp Glu Gly Pro Glu Ala Phe Leu Asp Ile 
        275                 280                 285             


Cys Pro Asp Asp Gly Ile Ala Leu Phe Glu Ala Ile Gln Met Val Tyr 
    290                 295                 300                 


Ser Ser Phe Ile Leu Thr Gly Met Leu Thr Glu Lys Gly Leu Ser Leu 
305                 310                 315                 320 


Ser Lys Ile Ser Ala Tyr Asn Gln Tyr Gly Gln Asp Leu Glu Ser Leu 
                325                 330                 335     


Lys Ala Leu Val Lys Glu Tyr Val Pro Asn Glu Tyr Ser Ser Phe Phe 
            340                 345                 350         


Arg Gly Pro Thr Tyr Ser Gly Ser Thr Glu Tyr Asp Pro Ser Lys Ala 
        355                 360                 365             


Gln Gly Tyr Thr Arg Tyr Asn Leu Gly Pro Ser Lys Lys Gly Ser Gly 
    370                 375                 380                 


Ala Lys Pro Met Ala Tyr Glu Asp Phe Lys Lys Ser Val Glu Gln Leu 
385                 390                 395                 400 


Phe Ala Asn Thr Asn Ala Ile Asn Asp Glu Arg Tyr Lys Glu Met Met 
                405                 410                 415     


Gly Arg Phe Ala Glu Glu Lys Phe Leu Arg Arg Leu Arg Thr Ser Asp 
            420                 425                 430         


Asn Gly Arg Ile Pro Phe Gln Leu Asn Leu Glu Glu Met Thr Ala Ile 
        435                 440                 445             


Ile Ile Asn Gln Gly Lys Tyr Tyr Pro Phe Leu Leu Glu Gln Gln Glu 
    450                 455                 460                 


Lys Leu Glu Ser Leu Val Arg Phe Arg Ile Pro Tyr Tyr Val Gly Pro 
465                 470                 475                 480 


Leu Thr Arg Ile Asn Ala Arg Leu Asp Ser Lys Gly Asn Ala Cys Phe 
                485                 490                 495     


Ala Trp Ser Lys Arg Lys Asp Gly Met Asp Ser Ala Ser Ile Lys Pro 
            500                 505                 510         


Trp Asn Trp Asp Glu Val Ile Asp Lys His Ala Ser Ala Gln Ala Phe 
        515                 520                 525             


Ile Glu Arg Met Thr Gly Thr Cys Thr Tyr Leu Arg Gly Glu Pro Val 
    530                 535                 540                 


Leu Pro Arg Cys Ser Leu Leu Tyr Glu Glu Tyr Cys Val Leu Asn Glu 
545                 550                 555                 560 


Leu Asn Gly Ala Arg Trp Thr Gln Asp Gly Asp Lys Phe Ile Arg Phe 
                565                 570                 575     


Asp Tyr Lys Asp Arg Ser Asp Ile Ile Glu Glu Leu Phe Lys Lys Arg 
            580                 585                 590         


Arg Gly Arg Ile Gln Tyr Ala Ala Val Ala Asp Trp Met Lys Gln Glu 
        595                 600                 605             


Arg Ser His Ala Asn Val His Val Ser Gly Gly Gln Gly Glu Asn Ala 
    610                 615                 620                 


Phe Glu Ser Arg Leu Ser Ser Tyr His Phe Phe Cys Asn Asp Val Phe 
625                 630                 635                 640 


Gly Val Asp Glu Leu Pro Gly Ser Tyr Val Asp Met Val Glu Glu Ile 
                645                 650                 655     


Ile Leu Trp Ser Thr Leu Phe Glu Asp Arg Ser Ile Leu Arg Glu Glu 
            660                 665                 670         


Ile Gln Arg Lys Tyr Gly Asp Val Leu Asn Glu Glu Gln Ile Lys Thr 
        675                 680                 685             


Ile Cys Lys Lys Arg Phe Ser Gly Trp Gly Arg Leu Ser Arg Lys Leu 
    690                 695                 700                 


Leu Cys Ser Leu Lys Ala Gln Thr Asp Asn Gly Pro Lys Ser Ile Met 
705                 710                 715                 720 


Asp Ile Leu Gln Glu Gly Asp Gln Asn Asn Gly Arg Val Gly Arg Ala 
                725                 730                 735     


Met Val Phe Gln Glu Ile Leu His Asp Glu Gln Leu Gly Phe Glu Gln 
            740                 745                 750         


Lys Ile Glu Glu Glu Asn Thr Gln Ser Met Leu Glu Gly Glu Asn Leu 
        755                 760                 765             


Leu Ile Glu Asp Leu Pro Gly Ser Pro Ala Ile Arg Arg Ser Ile Asn 
    770                 775                 780                 


Gln Ala Val Arg Ile Val Asp Glu Ile Val Gly Ile Ala Gly His Ala 
785                 790                 795                 800 


Pro Asp Asn Ile Phe Ile Glu Val Thr Arg Glu Asp Asp Thr Lys Lys 
                805                 810                 815     


Lys Gly Lys Arg Thr Thr Thr Arg Tyr Ser Asn Ile Gln Lys Ala Leu 
            820                 825                 830         


Glu Ala Leu Lys Glu Glu Gly Ala Glu Ala Leu Arg Glu Leu Lys Thr 
        835                 840                 845             


Tyr Lys His Asn Glu Leu Asp Lys Arg Leu Ser Leu Tyr Phe Met Gln 
    850                 855                 860                 


Asn Gly Lys Ser Leu Tyr Ser Gly Ile Pro Leu Asp Ile Arg Arg Leu 
865                 870                 875                 880 


Ser Glu Tyr Gln Ile Asp His Ile Ile Pro Gln Ser Tyr Ile Lys Asp 
                885                 890                 895     


Asp Ser Tyr Glu Asn Met Ala Leu Val Leu Pro Gly Glu Asn Gln Ser 
            900                 905                 910         


Lys Ala Asp Asn Leu Leu Ile Ser Gln Asp Ile Arg Ile Lys Met Lys 
        915                 920                 925             


Ala Thr Trp Thr Ala Leu His Lys Ala Gly Leu Met Gly Asp Lys Lys 
    930                 935                 940                 


Tyr Asn Asn Leu Met Asn Ser Ser Ile Ser Asp Ala Lys Met Lys Gly 
945                 950                 955                 960 


Phe Ile Asn Arg Gln Leu Val Glu Thr Ser Gln Ser Val Lys Leu Thr 
                965                 970                 975     


Gln Met Met Leu Ser Gln Lys Tyr Pro Gly Ala Lys Val Arg Pro Ile 
            980                 985                 990         


Lys Ala Ser Ile Ser Ser Gln Leu  Arg Asp Ala Cys Asp  Leu Val Lys 
        995                 1000                 1005             


Cys Arg  Glu Ala Asn Asp Tyr  His His Ala His Asp  Ala Tyr Leu 
    1010                 1015                 1020             


Ala Cys  Gln Val Gly Arg Phe  Val Leu Lys Arg His  Ser Ser Met 
    1025                 1030                 1035             


Phe Asp  Asn Pro Ile Gly Met  Thr Lys Val Ile Arg  Asp Phe Val 
    1040                 1045                 1050             


Lys Arg  Gln Gly Gln Glu Phe  Lys Arg Asn Gly Lys  Leu Pro Ala 
    1055                 1060                 1065             


Tyr Ala  Ser Arg Ser Gly Phe  Ile Val Gln Ser Phe  Met Arg Ser 
    1070                 1075                 1080             


Gly Phe  Asp Ala Glu Thr Gly  Glu Leu Leu Arg Asp  Asp Trp Asn 
    1085                 1090                 1095             


Ala Pro  Phe Glu Ile Ala Arg  Ile Lys Arg Cys Leu  Asn Tyr Arg 
    1100                 1105                 1110             


Asp Cys  Tyr Ile Ser Arg Met  Pro Met Glu Asp Ser  Gly Ala Phe 
    1115                 1120                 1125             


Trp Asp  Ala Thr Ile Tyr Ser  Pro Lys Ala Gly Lys  Lys Gly Ala 
    1130                 1135                 1140             


Leu Pro  Val Lys Gln Gly Leu  Pro Val Glu Lys Tyr  Gly Ser Tyr 
    1145                 1150                 1155             


Ser Arg  Glu Gln Phe Ala Tyr  Phe Phe Val Tyr Lys  Ala Tyr Asn 
    1160                 1165                 1170             


Pro Lys  Lys Lys Ala Tyr Arg  Leu Glu Phe Glu Ala  Val Pro Val 
    1175                 1180                 1185             


Arg Val  Ala Ser Ala Val Glu  Thr Arg Glu Asn Ala  Leu Glu Glu 
    1190                 1195                 1200             


Tyr Ala  Lys Ser Val Ala Lys  Gln Ala Gly Leu Glu  Phe Val Glu 
    1205                 1210                 1215             


Val Ala  Arg Pro Lys Val Tyr  Lys Tyr Gln Leu Ile  Glu Leu Gly 
    1220                 1225                 1230             


Glu Asp  Arg Leu Tyr Ile Thr  Gly Lys Arg Glu Val  Arg Asn Ala 
    1235                 1240                 1245             


Ser Gln  Leu Ala Phe Ser Leu  Asp Glu Ile Asp Leu  Leu Lys Arg 
    1250                 1255                 1260             


Leu Ala  Glu Gly Glu Glu Thr  Ser Ser Glu Glu Arg  Glu Arg Leu 
    1265                 1270                 1275             


Phe Asp  Val Leu Ile Glu Lys  Tyr Ala Arg Tyr Ala  Pro Arg Leu 
    1280                 1285                 1290             


Ala Arg  Gln Leu Ser Val Asp  Ser Met Ser Ala Thr  Phe Glu Thr 
    1295                 1300                 1305             


Leu Asn  Ala Glu Glu Gln Leu  Gly Ile Leu Leu Ser  Leu Val Glu 
    1310                 1315                 1320             


Ile Ala  Asn Gly Lys Arg Asn  Met Ile Asp Leu Ser  Ser Ala Gly 
    1325                 1330                 1335             


Gly Ser  Lys Asn Ala Gly Cys  Met Asn Pro Thr Phe  Ser Ser Glu 
    1340                 1345                 1350             


Leu Ser  Ser Pro Gly Ser Asn  Phe Thr Phe Ile Asp  Gln Ser Val 
    1355                 1360                 1365             


Thr Gly  Met Phe Glu Arg Arg  Gln Arg Leu Glu Leu  
    1370                 1375                 1380 


<210> 186
<211> 1195
<212> PRT
<213> Elusimicrobium minutum

<400> 186
Met Gln Lys Asn Ile Asn Thr Lys Gln Asn His Ile Tyr Ile Lys Gln 
1               5                   10                  15      


Ala Gln Lys Ile Lys Glu Lys Leu Gly Asp Lys Pro Tyr Arg Ile Gly 
            20                  25                  30          


Leu Asp Leu Gly Val Gly Ser Ile Gly Phe Ala Ile Val Ser Met Glu 
        35                  40                  45              


Glu Asn Asp Gly Asn Val Leu Leu Pro Lys Glu Ile Ile Met Val Gly 
    50                  55                  60                  


Ser Arg Ile Phe Lys Ala Ser Ala Gly Ala Ala Asp Arg Lys Leu Ser 
65                  70                  75                  80  


Arg Gly Gln Arg Asn Asn His Arg His Thr Arg Glu Arg Met Arg Tyr 
                85                  90                  95      


Leu Trp Lys Val Leu Ala Glu Gln Lys Leu Ala Leu Pro Val Pro Ala 
            100                 105                 110         


Asp Leu Asp Arg Lys Glu Asn Ser Ser Glu Gly Glu Thr Ser Ala Lys 
        115                 120                 125             


Arg Phe Leu Gly Asp Val Leu Gln Lys Asp Ile Tyr Glu Leu Arg Val 
    130                 135                 140                 


Lys Ser Leu Asp Glu Arg Leu Ser Leu Gln Glu Leu Gly Tyr Val Leu 
145                 150                 155                 160 


Tyr His Ile Ala Gly His Arg Gly Ser Ser Ala Ile Arg Thr Phe Glu 
                165                 170                 175     


Asn Asp Ser Glu Glu Ala Gln Lys Glu Asn Thr Glu Asn Lys Lys Ile 
            180                 185                 190         


Ala Gly Asn Ile Lys Arg Leu Met Ala Lys Lys Asn Tyr Arg Thr Tyr 
        195                 200                 205             


Gly Glu Tyr Leu Tyr Lys Glu Phe Phe Glu Asn Lys Glu Lys His Lys 
    210                 215                 220                 


Arg Glu Lys Ile Ser Asn Ala Ala Asn Asn His Lys Phe Ser Pro Thr 
225                 230                 235                 240 


Arg Asp Leu Val Ile Lys Glu Ala Glu Ala Ile Leu Lys Lys Gln Ala 
                245                 250                 255     


Gly Lys Asp Gly Phe His Lys Glu Leu Thr Glu Glu Tyr Ile Glu Lys 
            260                 265                 270         


Leu Thr Lys Ala Ile Gly Tyr Glu Ser Glu Lys Leu Ile Pro Glu Ser 
        275                 280                 285             


Gly Phe Cys Pro Tyr Leu Lys Asp Glu Lys Arg Leu Pro Ala Ser His 
    290                 295                 300                 


Lys Leu Asn Glu Glu Arg Arg Leu Trp Glu Thr Leu Asn Asn Ala Arg 
305                 310                 315                 320 


Tyr Ser Asp Pro Ile Val Asp Ile Val Thr Gly Glu Ile Thr Gly Tyr 
                325                 330                 335     


Tyr Glu Lys Gln Phe Thr Lys Glu Gln Lys Gln Lys Leu Phe Asp Tyr 
            340                 345                 350         


Leu Leu Thr Gly Ser Glu Leu Thr Pro Ala Gln Thr Lys Lys Leu Leu 
        355                 360                 365             


Gly Leu Lys Asn Thr Asn Phe Glu Asp Ile Ile Leu Gln Gly Arg Asp 
    370                 375                 380                 


Lys Lys Ala Gln Lys Ile Lys Gly Tyr Lys Leu Ile Lys Leu Glu Ser 
385                 390                 395                 400 


Met Pro Phe Trp Ala Arg Leu Ser Glu Ala Gln Gln Asp Ser Phe Leu 
                405                 410                 415     


Tyr Asp Trp Asn Ser Cys Pro Asp Glu Lys Leu Leu Thr Glu Lys Leu 
            420                 425                 430         


Ser Asn Glu Tyr His Leu Thr Glu Glu Glu Ile Asp Asn Ala Phe Asn 
        435                 440                 445             


Glu Ile Val Leu Ser Ser Ser Tyr Ala Pro Leu Gly Lys Ser Ala Met 
    450                 455                 460                 


Leu Ile Ile Leu Glu Lys Ile Lys Asn Asp Leu Ser Tyr Thr Glu Ala 
465                 470                 475                 480 


Val Glu Glu Ala Leu Lys Glu Gly Lys Leu Thr Lys Glu Lys Gln Ala 
                485                 490                 495     


Ile Lys Asp Arg Leu Pro Tyr Tyr Gly Ala Val Leu Gln Glu Ser Thr 
            500                 505                 510         


Gln Lys Ile Ile Ala Lys Gly Phe Ser Pro Gln Phe Lys Asp Lys Gly 
        515                 520                 525             


Tyr Lys Thr Pro His Thr Asn Lys Tyr Glu Leu Glu Tyr Gly Arg Ile 
    530                 535                 540                 


Ala Asn Pro Val Val His Gln Thr Leu Asn Glu Leu Arg Lys Leu Val 
545                 550                 555                 560 


Asn Glu Ile Ile Asp Ile Leu Gly Lys Lys Pro Cys Glu Ile Gly Leu 
                565                 570                 575     


Glu Thr Ala Arg Glu Leu Lys Lys Ser Ala Glu Asp Arg Ser Lys Leu 
            580                 585                 590         


Ser Arg Glu Gln Asn Asp Asn Glu Ser Asn Arg Asn Arg Ile Tyr Glu 
        595                 600                 605             


Ile Tyr Ile Arg Pro Gln Gln Gln Val Ile Ile Thr Arg Arg Glu Asn 
    610                 615                 620                 


Pro Arg Asn Tyr Ile Leu Lys Phe Glu Leu Leu Glu Glu Gln Lys Ser 
625                 630                 635                 640 


Gln Cys Pro Phe Cys Gly Gly Gln Ile Ser Pro Asn Asp Ile Ile Asn 
                645                 650                 655     


Asn Gln Ala Asp Ile Glu His Leu Phe Pro Ile Ala Glu Ser Glu Asp 
            660                 665                 670         


Asn Gly Arg Asn Asn Leu Val Ile Ser His Ser Ala Cys Asn Ala Asp 
        675                 680                 685             


Lys Ala Lys Arg Ser Pro Trp Ala Ala Phe Ala Ser Ala Ala Lys Asp 
    690                 695                 700                 


Ser Lys Tyr Asp Tyr Asn Arg Ile Leu Ser Asn Val Lys Glu Asn Ile 
705                 710                 715                 720 


Pro His Lys Ala Trp Arg Phe Asn Gln Gly Ala Phe Glu Lys Phe Ile 
                725                 730                 735     


Glu Asn Lys Pro Met Ala Ala Arg Phe Lys Thr Asp Asn Ser Tyr Ile 
            740                 745                 750         


Ser Lys Val Ala His Lys Tyr Leu Ala Cys Leu Phe Glu Lys Pro Asn 
        755                 760                 765             


Ile Ile Cys Val Lys Gly Ser Leu Thr Ala Gln Leu Arg Met Ala Trp 
    770                 775                 780                 


Gly Leu Gln Gly Leu Met Ile Pro Phe Ala Lys Gln Leu Ile Thr Glu 
785                 790                 795                 800 


Lys Glu Ser Glu Ser Phe Asn Lys Asp Val Asn Ser Asn Lys Lys Ile 
                805                 810                 815     


Arg Leu Asp Asn Arg His His Ala Leu Asp Ala Ile Val Ile Ala Tyr 
            820                 825                 830         


Ala Ser Arg Gly Tyr Gly Asn Leu Leu Asn Lys Met Ala Gly Lys Asp 
        835                 840                 845             


Tyr Lys Ile Asn Tyr Ser Glu Arg Asn Trp Leu Ser Lys Ile Leu Leu 
    850                 855                 860                 


Pro Pro Asn Asn Ile Val Trp Glu Asn Ile Asp Ala Asp Leu Glu Ser 
865                 870                 875                 880 


Phe Glu Ser Ser Val Lys Thr Ala Leu Lys Asn Ala Phe Ile Ser Val 
                885                 890                 895     


Lys His Asp His Ser Asp Asn Gly Glu Leu Val Lys Gly Thr Met Tyr 
            900                 905                 910         


Lys Ile Phe Tyr Ser Glu Arg Gly Tyr Thr Leu Thr Thr Tyr Lys Lys 
        915                 920                 925             


Leu Ser Ala Leu Lys Leu Thr Asp Pro Gln Lys Lys Lys Thr Pro Lys 
    930                 935                 940                 


Asp Phe Leu Glu Thr Ala Leu Leu Lys Phe Lys Gly Arg Glu Ser Glu 
945                 950                 955                 960 


Met Lys Asn Glu Lys Ile Lys Ser Ala Ile Glu Asn Asn Lys Arg Leu 
                965                 970                 975     


Phe Asp Val Ile Gln Asp Asn Leu Glu Lys Ala Lys Lys Leu Leu Glu 
            980                 985                 990         


Glu Glu Asn Glu Lys Ser Lys Ala  Glu Gly Lys Lys Glu  Lys Asn Ile 
        995                 1000                 1005             


Asn Asp  Ala Ser Ile Tyr Gln  Lys Ala Ile Ser Leu  Ser Gly Asp 
    1010                 1015                 1020             


Lys Tyr  Val Gln Leu Ser Lys  Lys Glu Pro Gly Lys  Phe Phe Ala 
    1025                 1030                 1035             


Ile Ser  Lys Pro Thr Pro Thr  Thr Thr Gly Tyr Gly  Tyr Asp Thr 
    1040                 1045                 1050             


Gly Asp  Ser Leu Cys Val Asp  Leu Tyr Tyr Asp Asn  Lys Gly Lys 
    1055                 1060                 1065             


Leu Cys  Gly Glu Ile Ile Arg  Lys Ile Asp Ala Gln  Gln Lys Asn 
    1070                 1075                 1080             


Pro Leu  Lys Tyr Lys Glu Gln  Gly Phe Thr Leu Phe  Glu Arg Ile 
    1085                 1090                 1095             


Tyr Gly  Gly Asp Ile Leu Glu  Val Asp Phe Asp Ile  His Ser Asp 
    1100                 1105                 1110             


Lys Asn  Ser Phe Arg Asn Asn  Thr Gly Ser Ala Pro  Glu Asn Arg 
    1115                 1120                 1125             


Val Phe  Ile Lys Val Gly Thr  Phe Thr Glu Ile Thr  Asn Asn Asn 
    1130                 1135                 1140             


Ile Gln  Ile Trp Phe Gly Asn  Ile Ile Lys Ser Thr  Gly Gly Gln 
    1145                 1150                 1155             


Asp Asp  Ser Phe Thr Ile Asn  Ser Met Gln Gln Tyr  Asn Pro Arg 
    1160                 1165                 1170             


Lys Leu  Ile Leu Ser Ser Cys  Gly Phe Ile Lys Tyr  Arg Ser Pro 
    1175                 1180                 1185             


Ile Leu  Lys Asn Lys Glu Gly  
    1190                 1195 


<210> 187
<211> 1337
<212> PRT
<213> Enterococcus faecalis


<220>
<223> Enterococcus faecalis ATCC 29200

<400> 187
Met Lys Lys Asp Tyr Val Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Met Thr Glu Asp Tyr Gln Leu Val Lys Lys Lys Met 
            20                  25                  30          


Pro Ile Tyr Gly Asn Thr Glu Lys Lys Lys Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Glu Glu Gly His Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Ile Ser Arg Arg Arg Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Ala Phe Phe Glu Glu Ala Met Thr Asp Leu Asp Glu Asn 
                85                  90                  95      


Phe Phe Ala Arg Leu Gln Glu Ser Phe Leu Val Pro Glu Asp Lys Lys 
            100                 105                 110         


Trp His Arg His Pro Ile Phe Ala Lys Leu Glu Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Gln Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Val Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Ser Thr 
                165                 170                 175     


Glu Asn Ile Ser Val Lys Glu Gln Phe Gln Gln Phe Met Ile Ile Tyr 
            180                 185                 190         


Asn Gln Thr Phe Val Asn Gly Glu Ser Arg Leu Val Ser Ala Pro Leu 
        195                 200                 205             


Pro Glu Ser Val Leu Ile Glu Glu Glu Leu Thr Glu Lys Ala Ser Arg 
    210                 215                 220                 


Thr Lys Lys Ser Glu Lys Val Leu Gln Gln Phe Pro Gln Glu Lys Ala 
225                 230                 235                 240 


Asn Gly Leu Phe Gly Gln Phe Leu Lys Leu Met Val Gly Asn Lys Ala 
                245                 250                 255     


Asp Phe Lys Lys Val Phe Gly Leu Glu Glu Glu Ala Lys Ile Thr Tyr 
            260                 265                 270         


Ala Ser Glu Ser Tyr Glu Glu Asp Leu Glu Gly Ile Leu Ala Lys Val 
        275                 280                 285             


Gly Asp Glu Tyr Ser Asp Val Phe Leu Ala Ala Lys Asn Val Tyr Asp 
    290                 295                 300                 


Ala Val Glu Leu Ser Thr Ile Leu Ala Asp Ser Asp Lys Lys Ser His 
305                 310                 315                 320 


Ala Lys Leu Ser Ser Ser Met Ile Val Arg Phe Thr Glu His Gln Glu 
                325                 330                 335     


Asp Leu Lys Lys Phe Lys Arg Phe Ile Arg Glu Asn Cys Pro Asp Glu 
            340                 345                 350         


Tyr Asp Asn Leu Phe Lys Asn Glu Gln Lys Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Ala His Ala Gly Lys Val Ser Gln Leu Lys Phe Tyr Gln Tyr Val 
    370                 375                 380                 


Lys Lys Ile Ile Gln Asp Ile Ala Gly Ala Glu Tyr Phe Leu Glu Lys 
385                 390                 395                 400 


Ile Ala Gln Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
                405                 410                 415     


Val Ile Pro His Gln Ile His Leu Ala Glu Leu Gln Ala Ile Ile His 
            420                 425                 430         


Arg Gln Ala Ala Tyr Tyr Pro Phe Leu Lys Glu Asn Gln Glu Lys Ile 
        435                 440                 445             


Glu Gln Leu Val Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ser 
    450                 455                 460                 


Lys Gly Asp Ala Ser Thr Phe Ala Trp Leu Lys Arg Gln Ser Glu Glu 
465                 470                 475                 480 


Pro Ile Arg Pro Trp Asn Leu Gln Glu Thr Val Asp Leu Asp Gln Ser 
                485                 490                 495     


Ala Thr Ala Phe Ile Glu Arg Met Thr Asn Phe Asp Thr Tyr Leu Pro 
            500                 505                 510         


Ser Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys Phe Met 
        515                 520                 525             


Val Phe Asn Glu Leu Thr Lys Ile Ser Tyr Thr Asp Asp Arg Gly Ile 
    530                 535                 540                 


Lys Ala Asn Phe Ser Gly Lys Glu Lys Glu Lys Ile Phe Asp Tyr Leu 
545                 550                 555                 560 


Phe Lys Thr Arg Arg Lys Val Lys Lys Lys Asp Ile Ile Gln Phe Tyr 
                565                 570                 575     


Arg Asn Glu Tyr Asn Thr Glu Ile Val Thr Leu Ser Gly Leu Glu Glu 
            580                 585                 590         


Asp Gln Phe Asn Ala Ser Phe Ser Thr Tyr Gln Asp Leu Leu Lys Cys 
        595                 600                 605             


Gly Leu Thr Arg Ala Glu Leu Asp His Pro Asp Asn Ala Glu Lys Leu 
    610                 615                 620                 


Glu Asp Ile Ile Lys Ile Leu Thr Ile Phe Glu Asp Arg Gln Arg Ile 
625                 630                 635                 640 


Arg Thr Gln Leu Ser Thr Phe Lys Gly Gln Phe Ser Ala Glu Val Leu 
                645                 650                 655     


Lys Lys Leu Glu Arg Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 
            660                 665                 670         


Lys Leu Ile Asn Gly Ile Tyr Asp Lys Glu Ser Gly Lys Thr Ile Leu 
        675                 680                 685             


Gly Tyr Leu Ile Lys Asp Asp Gly Val Ser Lys His Tyr Asn Arg Asn 
    690                 695                 700                 


Phe Met Gln Leu Ile Asn Asp Ser Gln Leu Ser Phe Lys Asn Ala Ile 
705                 710                 715                 720 


Gln Lys Ala Gln Ser Ser Glu His Glu Glu Thr Leu Ser Glu Thr Val 
                725                 730                 735     


Asn Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Tyr Gln Ser 
            740                 745                 750         


Leu Lys Ile Val Asp Glu Leu Val Ala Ile Met Gly Tyr Ala Pro Lys 
        755                 760                 765             


Arg Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Ser Thr Gly 
    770                 775                 780                 


Lys Arg Arg Ser Ile Gln Arg Leu Lys Ile Val Glu Lys Ala Met Ala 
785                 790                 795                 800 


Glu Ile Gly Ser Asn Leu Leu Lys Glu Gln Pro Thr Thr Asn Glu Gln 
                805                 810                 815     


Leu Arg Asp Thr Arg Leu Phe Leu Tyr Tyr Met Gln Asn Gly Lys Asp 
            820                 825                 830         


Met Tyr Thr Gly Asp Glu Leu Ser Leu His Arg Leu Ser His Tyr Asp 
        835                 840                 845             


Ile Asp His Ile Ile Pro Gln Ser Phe Met Lys Asp Asp Ser Leu Asp 
    850                 855                 860                 


Asn Leu Val Leu Val Gly Ser Thr Glu Asn Arg Gly Lys Ser Asp Asp 
865                 870                 875                 880 


Val Pro Ser Lys Glu Val Val Lys Asp Met Lys Ala Tyr Trp Glu Lys 
                885                 890                 895     


Leu Tyr Ala Ala Gly Leu Ile Ser Gln Arg Lys Phe Gln Arg Leu Thr 
            900                 905                 910         


Lys Gly Glu Gln Gly Gly Leu Thr Leu Glu Asp Lys Ala His Phe Ile 
        915                 920                 925             


Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys Asn Val Ala Gly 
    930                 935                 940                 


Ile Leu Asp Gln Arg Tyr Asn Ala Asn Ser Lys Glu Lys Lys Val Gln 
945                 950                 955                 960 


Ile Ile Thr Leu Lys Ala Ser Leu Thr Ser Gln Phe Arg Ser Ile Phe 
                965                 970                 975     


Gly Leu Tyr Lys Val Arg Glu Val Asn Asp Tyr His His Gly Gln Asp 
            980                 985                 990         


Ala Tyr Leu Asn Cys Val Val Ala  Thr Thr Leu Leu Lys  Val Tyr Pro 
        995                 1000                 1005             


Asn Leu  Ala Pro Glu Phe Val  Tyr Gly Glu Tyr Pro  Lys Phe Gln 
    1010                 1015                 1020             


Thr Phe  Lys Glu Asn Lys Ala  Thr Ala Lys Ala Ile  Ile Tyr Thr 
    1025                 1030                 1035             


Asn Leu  Leu Arg Phe Phe Thr  Glu Asp Glu Pro Arg  Phe Thr Lys 
    1040                 1045                 1050             


Asp Gly  Glu Ile Leu Trp Ser  Asn Ser Tyr Leu Lys  Thr Ile Lys 
    1055                 1060                 1065             


Lys Glu  Leu Asn Tyr His Gln  Met Asn Ile Val Lys  Lys Val Glu 
    1070                 1075                 1080             


Val Gln  Lys Gly Gly Phe Ser  Lys Glu Ser Ile Lys  Pro Lys Gly 
    1085                 1090                 1095             


Pro Ser  Asn Lys Leu Ile Pro  Val Lys Asn Gly Leu  Asp Pro Gln 
    1100                 1105                 1110             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Ile Val Ala Tyr  Thr Val Leu 
    1115                 1120                 1125             


Phe Thr  His Glu Lys Gly Lys  Lys Pro Leu Ile Lys  Gln Glu Ile 
    1130                 1135                 1140             


Leu Gly  Ile Thr Ile Met Glu  Lys Thr Arg Phe Glu  Gln Asn Pro 
    1145                 1150                 1155             


Ile Leu  Phe Leu Glu Glu Lys  Gly Phe Leu Arg Pro  Arg Val Leu 
    1160                 1165                 1170             


Met Lys  Leu Pro Lys Tyr Thr  Leu Tyr Glu Phe Pro  Glu Gly Arg 
    1175                 1180                 1185             


Arg Arg  Leu Leu Ala Ser Ala  Lys Glu Ala Gln Lys  Gly Asn Gln 
    1190                 1195                 1200             


Met Val  Leu Pro Glu His Leu  Leu Thr Leu Leu Tyr  His Ala Lys 
    1205                 1210                 1215             


Gln Cys  Leu Leu Pro Asn Gln  Ser Glu Ser Leu Ala  Tyr Val Glu 
    1220                 1225                 1230             


Gln His  Gln Pro Glu Phe Gln  Glu Ile Leu Glu Arg  Val Val Asp 
    1235                 1240                 1245             


Phe Ala  Glu Val His Thr Leu  Ala Lys Ser Lys Val  Gln Gln Ile 
    1250                 1255                 1260             


Val Lys  Leu Phe Glu Ala Asn  Gln Thr Ala Asp Val  Lys Glu Ile 
    1265                 1270                 1275             


Ala Ala  Ser Phe Ile Gln Leu  Met Gln Phe Asn Ala  Met Gly Ala 
    1280                 1285                 1290             


Pro Ser  Thr Phe Lys Phe Phe  Gln Lys Asp Ile Glu  Arg Ala Arg 
    1295                 1300                 1305             


Tyr Thr  Ser Ile Lys Glu Ile  Phe Asp Ala Thr Ile  Ile Tyr Gln 
    1310                 1315                 1320             


Ser Thr  Thr Gly Leu Tyr Glu  Thr Arg Arg Lys Val  Val Asp 
    1325                 1330                 1335         


<210> 188
<211> 1337
<212> PRT
<213> Enterococcus faecalis


<220>
<223> Enterococcus faecalis ATCC 4200

<400> 188
Met Lys Lys Asp Tyr Val Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Met Thr Glu Asp Tyr Gln Leu Val Lys Lys Lys Met 
            20                  25                  30          


Pro Ile Tyr Gly Asn Thr Glu Lys Lys Lys Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Glu Glu Gly His Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Ile Ser Arg Arg Arg Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Ala Phe Phe Glu Glu Ala Met Thr Ala Leu Asp Glu Asn 
                85                  90                  95      


Phe Phe Ala Arg Leu Gln Glu Ser Phe Leu Val Pro Glu Asp Lys Lys 
            100                 105                 110         


Trp His Arg His Pro Ile Phe Ala Lys Leu Glu Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Gln Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Val Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Ser Thr 
                165                 170                 175     


Glu Asn Ile Ser Val Lys Glu Gln Phe Gln Gln Phe Met Ile Ile Tyr 
            180                 185                 190         


Asn Gln Thr Phe Val Asn Gly Glu Ser Arg Leu Val Ser Ala Pro Leu 
        195                 200                 205             


Pro Glu Ser Val Leu Ile Glu Glu Glu Leu Thr Glu Lys Ala Ser Arg 
    210                 215                 220                 


Thr Lys Lys Ser Glu Lys Val Leu Gln Gln Phe Pro Gln Glu Lys Ala 
225                 230                 235                 240 


Asn Gly Leu Phe Gly Gln Phe Leu Lys Leu Met Val Gly Asn Lys Ala 
                245                 250                 255     


Asp Phe Lys Lys Val Phe Gly Leu Glu Glu Glu Ala Lys Ile Thr Tyr 
            260                 265                 270         


Ala Ser Glu Ser Tyr Glu Glu Asp Leu Glu Gly Ile Leu Ala Lys Val 
        275                 280                 285             


Gly Asp Glu Tyr Ser Asp Val Phe Leu Ala Ala Lys Asn Val Tyr Asp 
    290                 295                 300                 


Ala Val Glu Leu Ser Thr Ile Leu Ala Asp Ser Asp Lys Lys Ser His 
305                 310                 315                 320 


Ala Lys Leu Ser Ser Ser Met Ile Val Arg Phe Thr Glu His Gln Glu 
                325                 330                 335     


Asp Leu Lys Lys Phe Lys Arg Phe Ile Arg Glu Asn Cys Pro Asp Glu 
            340                 345                 350         


Tyr Asp Asn Leu Phe Lys Asn Glu Gln Lys Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Ala His Ala Gly Lys Val Ser Gln Leu Lys Phe Tyr Gln Tyr Val 
    370                 375                 380                 


Lys Lys Ile Ile Gln Asp Ile Ala Gly Ala Glu Tyr Phe Leu Glu Lys 
385                 390                 395                 400 


Ile Ala Gln Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
                405                 410                 415     


Val Ile Pro His Gln Ile His Leu Ala Glu Leu Gln Ala Ile Ile His 
            420                 425                 430         


Arg Gln Ala Ala Tyr Tyr Pro Phe Leu Lys Glu Asn Gln Glu Lys Ile 
        435                 440                 445             


Glu Gln Leu Val Thr Phe Arg Ile Pro Tyr Tyr Ile Gly Pro Leu Ser 
    450                 455                 460                 


Lys Gly Asp Ala Ser Thr Phe Ala Trp Leu Lys Arg Gln Ser Glu Glu 
465                 470                 475                 480 


Pro Ile Arg Pro Trp Asn Leu Gln Glu Thr Val Asp Leu Asp Gln Ser 
                485                 490                 495     


Ala Thr Ala Phe Ile Glu Arg Met Thr Asn Phe Asp Thr Tyr Leu Ser 
            500                 505                 510         


Ser Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys Phe Met 
        515                 520                 525             


Val Phe Asn Glu Leu Thr Lys Ile Ser Tyr Thr Asp Asp Arg Gly Ile 
    530                 535                 540                 


Lys Ala Asn Phe Ser Gly Lys Glu Lys Glu Lys Ile Phe Asp Tyr Leu 
545                 550                 555                 560 


Phe Lys Thr Arg Arg Lys Val Lys Lys Lys Asp Ile Ile Gln Phe Tyr 
                565                 570                 575     


Arg Asn Glu Tyr Asn Thr Glu Ile Val Thr Leu Ser Gly Leu Glu Glu 
            580                 585                 590         


Asp Gln Phe Asn Ala Ser Phe Ser Thr Tyr Gln Asp Leu Leu Lys Cys 
        595                 600                 605             


Gly Leu Thr Arg Ala Glu Leu Asp His Pro Asp Asn Ala Glu Lys Leu 
    610                 615                 620                 


Glu Asp Ile Ile Lys Ile Leu Thr Ile Phe Glu Asp Arg Gln Arg Ile 
625                 630                 635                 640 


Arg Thr Gln Leu Ser Thr Phe Lys Gly Gln Phe Ser Ala Glu Val Leu 
                645                 650                 655     


Lys Lys Leu Glu Arg Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 
            660                 665                 670         


Lys Leu Ile Asn Gly Ile Tyr Asp Lys Glu Ser Gly Lys Thr Ile Leu 
        675                 680                 685             


Gly Tyr Leu Ile Lys Asp Asp Gly Val Ser Lys His Tyr Asn Arg Asn 
    690                 695                 700                 


Phe Met Gln Leu Ile Asn Asp Ser Gln Leu Ser Phe Lys Asn Ala Ile 
705                 710                 715                 720 


Gln Lys Ala Gln Ser Ser Glu His Glu Glu Thr Leu Ser Glu Thr Val 
                725                 730                 735     


Asn Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Tyr Gln Ser 
            740                 745                 750         


Leu Lys Ile Val Asp Glu Leu Val Ala Ile Met Gly Tyr Ala Pro Lys 
        755                 760                 765             


Arg Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Ser Thr Gly 
    770                 775                 780                 


Lys Arg Arg Ser Ile Gln Arg Leu Lys Ile Val Glu Lys Ala Met Ala 
785                 790                 795                 800 


Glu Ile Gly Ser Asn Leu Leu Lys Glu Gln Pro Thr Thr Asn Glu Gln 
                805                 810                 815     


Leu Arg Asp Thr Arg Leu Phe Leu Tyr Tyr Met Gln Asn Gly Lys Asp 
            820                 825                 830         


Met Tyr Thr Gly Asp Glu Leu Ser Leu His Arg Leu Ser His Tyr Asp 
        835                 840                 845             


Ile Asp His Ile Ile Pro Gln Ser Phe Met Lys Asp Asp Ser Leu Asp 
    850                 855                 860                 


Asn Leu Val Leu Val Gly Ser Thr Glu Asn Arg Gly Lys Ser Asp Asp 
865                 870                 875                 880 


Val Pro Ser Lys Glu Val Val Lys Asp Met Lys Ala Tyr Trp Glu Lys 
                885                 890                 895     


Leu Tyr Ala Ala Gly Leu Ile Ser Gln Arg Lys Phe Gln Arg Leu Thr 
            900                 905                 910         


Lys Gly Glu Gln Gly Gly Leu Thr Leu Glu Asp Lys Ala His Phe Ile 
        915                 920                 925             


Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys Asn Val Ala Gly 
    930                 935                 940                 


Ile Leu Asp Gln Arg Tyr Asn Ala Asn Ser Lys Glu Lys Lys Val Gln 
945                 950                 955                 960 


Ile Ile Thr Leu Lys Ala Ser Leu Thr Ser Gln Phe Arg Ser Ile Phe 
                965                 970                 975     


Gly Leu Tyr Lys Val Arg Glu Val Asn Asp Tyr His His Gly Gln Asp 
            980                 985                 990         


Ala Tyr Leu Asn Cys Val Val Ala  Thr Thr Leu Leu Lys  Val Tyr Pro 
        995                 1000                 1005             


Asn Leu  Ala Pro Glu Phe Val  Tyr Gly Glu Tyr Pro  Lys Phe Gln 
    1010                 1015                 1020             


Ala Phe  Lys Glu Asn Lys Ala  Thr Ala Lys Ala Ile  Ile Tyr Thr 
    1025                 1030                 1035             


Asn Leu  Leu Arg Phe Phe Thr  Glu Asp Glu Pro Arg  Phe Thr Lys 
    1040                 1045                 1050             


Asp Gly  Glu Ile Leu Trp Ser  Asn Ser Tyr Leu Lys  Thr Ile Lys 
    1055                 1060                 1065             


Lys Glu  Leu Asn Tyr His Gln  Met Asn Ile Val Lys  Lys Val Glu 
    1070                 1075                 1080             


Val Gln  Lys Gly Gly Phe Ser  Lys Glu Ser Ile Lys  Pro Lys Gly 
    1085                 1090                 1095             


Pro Ser  Asn Lys Leu Ile Pro  Val Lys Asn Gly Leu  Asp Pro Gln 
    1100                 1105                 1110             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Val Val Ala Tyr  Thr Val Leu 
    1115                 1120                 1125             


Phe Thr  His Glu Lys Gly Lys  Lys Pro Leu Ile Lys  Gln Glu Ile 
    1130                 1135                 1140             


Leu Gly  Ile Thr Ile Met Glu  Lys Thr Arg Phe Glu  Gln Asn Pro 
    1145                 1150                 1155             


Ile Leu  Phe Leu Glu Glu Lys  Gly Phe Leu Arg Pro  Arg Val Leu 
    1160                 1165                 1170             


Met Lys  Leu Pro Lys Tyr Thr  Leu Tyr Glu Phe Pro  Glu Gly Arg 
    1175                 1180                 1185             


Arg Arg  Leu Leu Ala Ser Ala  Lys Glu Ala Gln Lys  Gly Asn Gln 
    1190                 1195                 1200             


Met Val  Leu Pro Glu His Leu  Leu Thr Leu Leu Tyr  His Ala Lys 
    1205                 1210                 1215             


Gln Cys  Leu Leu Pro Asn Gln  Ser Glu Ser Leu Ala  Tyr Val Glu 
    1220                 1225                 1230             


Gln His  Gln Pro Glu Phe Gln  Glu Ile Leu Glu Arg  Val Val Asp 
    1235                 1240                 1245             


Phe Ala  Glu Val His Thr Leu  Ala Lys Ser Lys Val  Gln Gln Ile 
    1250                 1255                 1260             


Val Lys  Leu Phe Glu Ala Asn  Gln Thr Ala Asp Val  Lys Glu Ile 
    1265                 1270                 1275             


Ala Ala  Ser Phe Ile Gln Leu  Met Gln Phe Asn Ala  Met Gly Ala 
    1280                 1285                 1290             


Pro Ser  Thr Phe Lys Phe Phe  Gln Lys Asp Ile Glu  Arg Ala Arg 
    1295                 1300                 1305             


Tyr Thr  Ser Ile Lys Glu Ile  Phe Asp Ala Thr Ile  Ile Tyr Gln 
    1310                 1315                 1320             


Ser Thr  Thr Gly Leu Tyr Glu  Thr Arg Arg Lys Val  Val Asp 
    1325                 1330                 1335         


<210> 189
<211> 1337
<212> PRT
<213> Enterococcus faecalis


<220>
<223> Enterococcus faecalis D6

<400> 189
Met Lys Lys Asp Tyr Val Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Met Thr Glu Asp Tyr Gln Leu Val Lys Lys Lys Met 
            20                  25                  30          


Pro Ile Tyr Gly Asn Thr Glu Lys Lys Lys Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Glu Glu Gly His Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Ile Ser Arg Arg Arg Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Ala Phe Phe Glu Glu Ala Met Thr Ala Leu Asp Glu Asn 
                85                  90                  95      


Phe Phe Ala Arg Leu Gln Glu Ser Phe Leu Val Pro Glu Asp Lys Lys 
            100                 105                 110         


Trp His Arg His Pro Ile Phe Ala Lys Leu Glu Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Gln Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Val Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Ser Thr 
                165                 170                 175     


Glu Asn Ile Ser Val Lys Glu Gln Phe Gln Gln Phe Met Ile Ile Tyr 
            180                 185                 190         


Asn Gln Thr Phe Val Asn Gly Glu Ser Arg Leu Val Ser Ala Pro Leu 
        195                 200                 205             


Pro Glu Ser Val Leu Ile Glu Glu Glu Leu Thr Glu Lys Ala Ser Arg 
    210                 215                 220                 


Thr Lys Lys Ser Glu Lys Val Leu Gln Gln Phe Pro Gln Glu Lys Ala 
225                 230                 235                 240 


Asn Gly Leu Phe Gly Gln Phe Leu Lys Leu Met Val Gly Asn Lys Ala 
                245                 250                 255     


Asp Phe Lys Lys Val Phe Gly Leu Glu Glu Glu Ala Lys Ile Thr Tyr 
            260                 265                 270         


Ala Ser Glu Ser Tyr Glu Glu Asp Leu Glu Gly Ile Leu Ala Lys Val 
        275                 280                 285             


Gly Asp Glu Tyr Ser Asp Val Phe Leu Ala Ala Lys Asn Val Tyr Asp 
    290                 295                 300                 


Ala Val Glu Leu Ser Thr Ile Leu Ala Asp Ser Asp Lys Lys Ser His 
305                 310                 315                 320 


Ala Lys Leu Ser Ser Ser Met Ile Val Arg Phe Thr Glu His Gln Glu 
                325                 330                 335     


Asp Leu Lys Asn Phe Lys Arg Phe Ile Arg Glu Asn Cys Pro Asp Glu 
            340                 345                 350         


Tyr Asp Asn Leu Phe Lys Asn Glu Gln Lys Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Thr His Ala Gly Lys Val Ser Gln Leu Lys Phe Tyr Gln Tyr Val 
    370                 375                 380                 


Lys Lys Ile Ile Gln Asp Ile Ala Gly Ala Glu Tyr Phe Leu Glu Lys 
385                 390                 395                 400 


Ile Ala Gln Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
                405                 410                 415     


Val Ile Pro His Gln Ile His Leu Ala Glu Leu Gln Ala Ile Ile His 
            420                 425                 430         


Arg Gln Ala Ala Tyr Tyr Pro Phe Leu Lys Glu Asn Gln Glu Lys Ile 
        435                 440                 445             


Glu Gln Leu Val Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ser 
    450                 455                 460                 


Lys Gly Asp Ala Asn Thr Phe Ala Trp Leu Lys Arg Gln Ser Glu Glu 
465                 470                 475                 480 


Pro Ile Arg Pro Trp Asn Leu Gln Glu Thr Val Asp Leu Asp Gln Ser 
                485                 490                 495     


Ala Thr Ala Phe Ile Glu Arg Met Thr Asn Phe Asp Thr Tyr Leu Pro 
            500                 505                 510         


Ser Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys Phe Met 
        515                 520                 525             


Val Phe Asn Glu Leu Thr Lys Ile Ser Tyr Thr Asp Asp Arg Gly Ile 
    530                 535                 540                 


Lys Ala Asn Phe Ser Gly Lys Glu Lys Glu Lys Ile Phe Asp Tyr Leu 
545                 550                 555                 560 


Phe Lys Thr Arg Arg Lys Val Lys Lys Lys Asp Ile Ile Gln Phe Tyr 
                565                 570                 575     


Arg Asn Glu Tyr Asn Thr Glu Ile Val Thr Leu Ser Gly Leu Glu Glu 
            580                 585                 590         


Asp Gln Phe Asn Ala Ser Phe Ser Thr Tyr Gln Asp Leu Leu Lys Cys 
        595                 600                 605             


Gly Leu Thr Arg Ala Glu Leu Asp His Pro Asp Asn Ala Glu Lys Leu 
    610                 615                 620                 


Glu Asp Ile Ile Lys Ile Leu Thr Ile Phe Glu Asp Arg Gln Arg Ile 
625                 630                 635                 640 


Arg Thr Gln Leu Ser Thr Phe Lys Gly Gln Phe Ser Ala Glu Val Leu 
                645                 650                 655     


Lys Lys Leu Glu Arg Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 
            660                 665                 670         


Lys Leu Ile Asn Gly Ile Tyr Asp Lys Glu Ser Gly Lys Thr Ile Leu 
        675                 680                 685             


Asp Tyr Leu Ile Lys Asp Asp Gly Val Ser Lys His Tyr Asn Arg Asn 
    690                 695                 700                 


Phe Met Gln Leu Ile Asn Asp Ser Gln Leu Ser Phe Lys Asn Ala Ile 
705                 710                 715                 720 


Gln Lys Ala Gln Ser Ser Glu His Glu Glu Thr Leu Ser Glu Thr Val 
                725                 730                 735     


Asn Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Tyr Gln Ser 
            740                 745                 750         


Leu Lys Ile Val Asp Glu Leu Val Ala Ile Met Gly Tyr Ala Pro Lys 
        755                 760                 765             


Arg Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Ser Thr Gly 
    770                 775                 780                 


Lys Arg Arg Ser Ile Gln Arg Leu Lys Ile Val Glu Lys Ala Met Ala 
785                 790                 795                 800 


Glu Ile Gly Ser Asn Leu Leu Lys Glu Gln Pro Thr Thr Asn Glu Gln 
                805                 810                 815     


Leu Arg Asp Thr Arg Leu Phe Leu Tyr Tyr Met Gln Asn Gly Lys Asp 
            820                 825                 830         


Met Tyr Thr Gly Asp Glu Leu Ser Leu His Arg Leu Ser His Tyr Asp 
        835                 840                 845             


Ile Asp His Ile Ile Pro Gln Ser Phe Met Lys Asp Asp Ser Leu Asp 
    850                 855                 860                 


Asn Leu Val Leu Val Gly Ser Thr Glu Asn Arg Gly Lys Ser Asp Asp 
865                 870                 875                 880 


Val Pro Ser Lys Glu Val Val Lys Asp Met Lys Ala Tyr Trp Glu Lys 
                885                 890                 895     


Leu Tyr Ala Ala Gly Leu Ile Ser Gln Arg Lys Phe Gln Arg Leu Thr 
            900                 905                 910         


Lys Gly Glu Gln Gly Gly Leu Thr Leu Glu Asp Lys Ala His Phe Ile 
        915                 920                 925             


Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys Asn Val Ala Gly 
    930                 935                 940                 


Ile Leu Asp Gln Arg Tyr Asn Ala Lys Ser Lys Glu Lys Lys Val Gln 
945                 950                 955                 960 


Ile Ile Thr Leu Lys Ala Ser Leu Thr Ser Gln Phe Arg Ser Ile Phe 
                965                 970                 975     


Gly Leu Tyr Lys Val Arg Glu Val Asn Asp Tyr His His Gly Gln Asp 
            980                 985                 990         


Ala Tyr Leu Asn Cys Val Val Ala  Thr Thr Leu Leu Lys  Val Tyr Pro 
        995                 1000                 1005             


Asn Leu  Ala Pro Glu Phe Val  Tyr Gly Glu Tyr Pro  Lys Phe Gln 
    1010                 1015                 1020             


Thr Phe  Lys Glu Asn Lys Ala  Thr Ala Lys Ala Ile  Ile Tyr Thr 
    1025                 1030                 1035             


Asn Leu  Leu Arg Phe Phe Thr  Glu Asp Glu Pro Arg  Phe Thr Lys 
    1040                 1045                 1050             


Asp Gly  Glu Ile Leu Trp Ser  Asn Ser Tyr Leu Lys  Thr Ile Lys 
    1055                 1060                 1065             


Lys Glu  Leu Asn Tyr His Gln  Met Asn Ile Val Lys  Lys Val Glu 
    1070                 1075                 1080             


Val Gln  Lys Gly Gly Phe Ser  Lys Glu Ser Ile Lys  Pro Lys Gly 
    1085                 1090                 1095             


Pro Ser  Asn Lys Leu Ile Pro  Val Lys Asn Gly Leu  Asp Pro Gln 
    1100                 1105                 1110             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Ile Val Ala Tyr  Thr Val Leu 
    1115                 1120                 1125             


Phe Thr  His Glu Lys Gly Lys  Lys Pro Leu Ile Lys  Gln Glu Ile 
    1130                 1135                 1140             


Leu Gly  Ile Thr Ile Met Glu  Lys Thr Arg Phe Glu  Gln Asn Pro 
    1145                 1150                 1155             


Ile Leu  Phe Leu Glu Glu Lys  Gly Phe Leu Arg Pro  Arg Val Leu 
    1160                 1165                 1170             


Met Lys  Leu Pro Lys Tyr Thr  Leu Tyr Gln Phe Pro  Glu Gly Arg 
    1175                 1180                 1185             


Arg Arg  Leu Leu Ala Ser Ala  Lys Glu Ala Gln Lys  Gly Asn Gln 
    1190                 1195                 1200             


Met Val  Leu Pro Glu His Leu  Leu Thr Leu Leu Tyr  His Ala Lys 
    1205                 1210                 1215             


Gln Cys  Leu Leu Pro Asn Gln  Ser Glu Ser Leu Ala  Tyr Val Glu 
    1220                 1225                 1230             


Gln His  Gln Pro Glu Phe Gln  Glu Ile Leu Glu Arg  Val Val Asp 
    1235                 1240                 1245             


Phe Ala  Glu Val His Thr Leu  Ala Lys Ser Lys Val  Gln Gln Ile 
    1250                 1255                 1260             


Val Lys  Leu Phe Glu Ala Asn  Gln Thr Ala Asp Val  Lys Glu Ile 
    1265                 1270                 1275             


Ala Ala  Ser Phe Ile Gln Leu  Met Gln Phe Asn Ala  Met Gly Ala 
    1280                 1285                 1290             


Pro Ser  Thr Phe Lys Phe Phe  Gln Lys Asp Ile Glu  Arg Ala Arg 
    1295                 1300                 1305             


Tyr Thr  Ser Ile Lys Glu Ile  Phe Asp Ala Thr Ile  Ile Tyr Gln 
    1310                 1315                 1320             


Ser Thr  Thr Gly Leu Tyr Glu  Thr Arg Arg Lys Val  Val Asp 
    1325                 1330                 1335         


<210> 190
<211> 1337
<212> PRT
<213> Enterococcus faecalis


<220>
<223> Enterococcus faecalis E1Sol

<400> 190
Met Lys Lys Asp Tyr Val Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Met Thr Glu Asp Tyr Gln Leu Val Lys Lys Lys Met 
            20                  25                  30          


Pro Ile Tyr Gly Asn Thr Glu Lys Lys Lys Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Glu Glu Gly His Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Ile Ser Arg Arg Arg Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Ala Phe Phe Glu Glu Ala Met Thr Asp Leu Asp Glu Asn 
                85                  90                  95      


Phe Phe Ala Arg Leu Gln Glu Ser Phe Leu Val Pro Glu Asp Lys Lys 
            100                 105                 110         


Trp His Arg His Pro Ile Phe Ala Lys Leu Glu Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Gln Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Val Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Ser Thr 
                165                 170                 175     


Glu Asn Thr Ser Val Lys Glu Gln Phe Gln Gln Phe Met Val Ile Tyr 
            180                 185                 190         


Asn Gln Thr Phe Val Asn Gly Glu Ser Arg Leu Val Ser Ala Pro Leu 
        195                 200                 205             


Pro Glu Ser Val Leu Ile Glu Glu Glu Leu Thr Glu Lys Ala Ser Arg 
    210                 215                 220                 


Thr Lys Lys Ser Glu Lys Val Leu Gln Gln Phe Pro Gln Glu Lys Ala 
225                 230                 235                 240 


Asn Gly Leu Phe Gly Gln Phe Leu Lys Leu Met Val Gly Asn Lys Ala 
                245                 250                 255     


Asp Phe Lys Lys Val Phe Gly Leu Glu Glu Glu Ala Lys Ile Thr Tyr 
            260                 265                 270         


Ala Ser Glu Ser Tyr Glu Glu Asp Leu Glu Gly Ile Leu Ala Lys Val 
        275                 280                 285             


Gly Asp Glu Tyr Ser Asp Val Phe Leu Ala Ala Lys Asn Val Tyr Asp 
    290                 295                 300                 


Ala Val Glu Leu Ser Thr Ile Leu Ala Asp Ser Asp Lys Lys Ser His 
305                 310                 315                 320 


Ala Lys Leu Ser Ser Ser Met Ile Val Arg Phe Thr Glu His Gln Glu 
                325                 330                 335     


Asp Leu Lys Lys Phe Lys Arg Phe Ile Arg Glu Asn Cys Pro Asp Glu 
            340                 345                 350         


Tyr Asp Asn Leu Phe Lys Asn Glu Gln Lys Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Ala His Ala Gly Lys Val Ser Gln Leu Lys Phe Tyr Gln Tyr Val 
    370                 375                 380                 


Lys Lys Ile Ile Gln Asp Ile Ala Gly Ala Glu Tyr Phe Leu Glu Lys 
385                 390                 395                 400 


Ile Ala Gln Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
                405                 410                 415     


Val Ile Pro His Gln Ile His Leu Ala Glu Leu Gln Ala Ile Ile His 
            420                 425                 430         


Arg Gln Ala Ala Tyr Tyr Pro Phe Leu Lys Glu Asn Gln Glu Lys Ile 
        435                 440                 445             


Glu Gln Leu Val Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ser 
    450                 455                 460                 


Lys Gly Asp Ala Ser Thr Phe Ala Trp Leu Lys Arg Gln Ser Glu Glu 
465                 470                 475                 480 


Pro Ile Arg Pro Trp Asn Leu Gln Glu Thr Val Asp Leu Asp Gln Ser 
                485                 490                 495     


Ala Thr Ala Phe Ile Glu Arg Met Thr Asn Phe Asp Thr Tyr Leu Pro 
            500                 505                 510         


Ser Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys Phe Met 
        515                 520                 525             


Val Phe Asn Glu Leu Thr Lys Ile Ser Tyr Thr Asp Asp Arg Gly Ile 
    530                 535                 540                 


Lys Ala Asn Phe Ser Gly Lys Glu Lys Glu Lys Ile Phe Asp Tyr Leu 
545                 550                 555                 560 


Phe Lys Thr Arg Arg Lys Val Lys Lys Lys Asp Ile Ile Gln Phe Tyr 
                565                 570                 575     


Arg Asn Glu Tyr Asn Thr Glu Ile Val Thr Leu Ser Gly Leu Glu Glu 
            580                 585                 590         


Asp Gln Phe Asn Ala Ser Phe Ser Thr Tyr Gln Asp Leu Leu Lys Cys 
        595                 600                 605             


Gly Leu Thr Arg Ala Glu Leu Asp His Pro Asp Asn Ala Glu Lys Leu 
    610                 615                 620                 


Glu Asp Ile Ile Lys Ile Leu Thr Ile Phe Glu Asp Arg Gln Arg Ile 
625                 630                 635                 640 


Arg Thr Gln Leu Ser Thr Phe Lys Gly Gln Phe Ser Ala Glu Val Leu 
                645                 650                 655     


Lys Lys Leu Glu Arg Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 
            660                 665                 670         


Lys Leu Ile Asn Gly Ile Tyr Asp Lys Glu Ser Gly Lys Thr Ile Leu 
        675                 680                 685             


Asp Tyr Leu Val Lys Asp Asp Gly Val Ser Lys His Tyr Asn Arg Asn 
    690                 695                 700                 


Phe Met Gln Leu Ile Asn Asp Ser Gln Leu Ser Phe Lys Asn Ala Ile 
705                 710                 715                 720 


Gln Lys Ala Gln Ser Ser Glu His Glu Glu Thr Leu Ser Glu Thr Val 
                725                 730                 735     


Asn Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Tyr Gln Ser 
            740                 745                 750         


Leu Lys Ile Val Asp Glu Leu Val Ala Ile Met Gly Tyr Ala Pro Lys 
        755                 760                 765             


Arg Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Ser Thr Gly 
    770                 775                 780                 


Lys Arg Arg Ser Ile Gln Arg Leu Lys Ile Val Glu Lys Ala Met Ala 
785                 790                 795                 800 


Glu Ile Gly Ser Asn Leu Leu Lys Glu Gln Pro Thr Thr Asn Glu Gln 
                805                 810                 815     


Leu Arg Asp Thr Arg Leu Phe Leu Tyr Tyr Met Gln Asn Gly Lys Asp 
            820                 825                 830         


Met Tyr Thr Gly Asp Glu Leu Ser Leu His Arg Leu Ser His Tyr Asp 
        835                 840                 845             


Ile Asp His Ile Ile Pro Gln Ser Phe Met Lys Asp Asp Ser Leu Asp 
    850                 855                 860                 


Asn Leu Val Leu Val Gly Ser Thr Glu Asn Arg Gly Lys Ser Asp Asp 
865                 870                 875                 880 


Val Pro Ser Lys Lys Val Val Lys Lys Met Lys Ala Tyr Trp Glu Lys 
                885                 890                 895     


Leu Tyr Ala Ala Gly Leu Ile Ser Gln Arg Lys Phe Gln Arg Leu Thr 
            900                 905                 910         


Lys Gly Glu Gln Gly Gly Leu Thr Leu Glu Asp Lys Ala His Phe Ile 
        915                 920                 925             


Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys Asn Val Ala Gly 
    930                 935                 940                 


Ile Leu Asp Gln Arg Tyr Asn Ala Lys Ser Lys Glu Lys Lys Val Gln 
945                 950                 955                 960 


Ile Ile Thr Leu Lys Ala Ser Leu Thr Ser Gln Phe Arg Ser Ile Phe 
                965                 970                 975     


Gly Leu Tyr Lys Val Arg Glu Val Asn Asp Tyr His His Gly Gln Asp 
            980                 985                 990         


Ala Tyr Leu Asn Cys Val Val Ala  Thr Thr Leu Leu Lys  Val Tyr Pro 
        995                 1000                 1005             


Asn Leu  Ala Pro Glu Phe Val  Tyr Gly Glu Tyr Pro  Lys Phe Gln 
    1010                 1015                 1020             


Ala Phe  Lys Glu Asn Lys Ala  Thr Ala Lys Thr Ile  Ile Tyr Thr 
    1025                 1030                 1035             


Asn Leu  Met Arg Phe Phe Thr  Glu Asp Glu Pro Arg  Phe Thr Lys 
    1040                 1045                 1050             


Asp Ser  Glu Ile Leu Trp Ser  Asn Ser Tyr Leu Lys  Thr Ile Lys 
    1055                 1060                 1065             


Lys Glu  Leu Asn Tyr His Gln  Met Asn Ile Val Lys  Lys Val Glu 
    1070                 1075                 1080             


Val Gln  Lys Gly Gly Phe Ser  Lys Glu Ser Ile Lys  Pro Lys Gly 
    1085                 1090                 1095             


Pro Ser  Asn Lys Leu Ile Pro  Val Lys Asn Gly Leu  Asp Pro Gln 
    1100                 1105                 1110             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Val Val Ala Tyr  Thr Val Leu 
    1115                 1120                 1125             


Phe Thr  His Glu Lys Gly Lys  Lys Pro Leu Ile Lys  Gln Glu Ile 
    1130                 1135                 1140             


Leu Gly  Ile Thr Ile Met Glu  Lys Thr Arg Phe Glu  Gln Asn Pro 
    1145                 1150                 1155             


Ile Leu  Phe Leu Glu Glu Lys  Gly Phe Leu Arg Pro  Arg Val Leu 
    1160                 1165                 1170             


Met Lys  Leu Pro Lys Tyr Thr  Leu Tyr Glu Phe Pro  Glu Gly Arg 
    1175                 1180                 1185             


Arg Arg  Leu Leu Ala Ser Ala  Lys Glu Ala Gln Lys  Gly Asn Gln 
    1190                 1195                 1200             


Met Val  Leu Pro Glu His Leu  Leu Thr Leu Leu Tyr  His Ala Lys 
    1205                 1210                 1215             


Gln Cys  Leu Leu Pro Asn Gln  Ser Glu Ser Leu Ala  Tyr Val Glu 
    1220                 1225                 1230             


Gln His  Gln Pro Glu Phe Gln  Glu Ile Leu Glu Arg  Val Val Asp 
    1235                 1240                 1245             


Phe Ala  Glu Val His Thr Leu  Ala Lys Ser Lys Val  Gln Gln Ile 
    1250                 1255                 1260             


Val Lys  Leu Phe Glu Ala Asn  Gln Thr Ala Asp Val  Lys Glu Ile 
    1265                 1270                 1275             


Ala Ala  Ser Phe Ile Gln Leu  Met Gln Phe Asn Ala  Met Gly Ala 
    1280                 1285                 1290             


Pro Ser  Thr Phe Lys Phe Phe  Gln Lys Asp Ile Glu  Arg Ala Arg 
    1295                 1300                 1305             


Tyr Thr  Ser Ile Lys Glu Ile  Phe Asp Ala Thr Ile  Ile Tyr Gln 
    1310                 1315                 1320             


Ser Thr  Thr Gly Leu Tyr Glu  Thr Arg Arg Lys Val  Val Asp 
    1325                 1330                 1335         


<210> 191
<211> 1150
<212> PRT
<213> Enterococcus faecalis


<220>
<223> Enterococcus faecalis Fly1

<400> 191
Met Tyr Ser Ile Gly Leu Asp Leu Gly Ile Ser Ser Val Gly Trp Ser 
1               5                   10                  15      


Val Ile Asp Glu Arg Thr Gly Asn Val Ile Asp Leu Gly Val Arg Leu 
            20                  25                  30          


Phe Ser Ala Lys Asn Ser Glu Lys Asn Leu Glu Arg Arg Thr Asn Arg 
        35                  40                  45              


Gly Gly Arg Arg Leu Ile Arg Arg Lys Thr Asn Arg Leu Lys Asp Ala 
    50                  55                  60                  


Lys Lys Ile Leu Ala Ala Val Gly Phe Tyr Glu Asp Lys Ser Leu Lys 
65                  70                  75                  80  


Asn Ser Cys Pro Tyr Gln Leu Arg Val Lys Gly Leu Thr Glu Pro Leu 
                85                  90                  95      


Ser Lys Gly Glu Ile Tyr Lys Val Thr Leu His Ile Leu Lys Lys Arg 
            100                 105                 110         


Gly Ile Ser Tyr Leu Asp Glu Asp Asp Thr Glu Ala Ala Lys Glu Ser 
        115                 120                 125             


Gln Asp Tyr Lys Glu Gln Val Arg Lys Asn Ala Gln Leu Leu Thr Lys 
    130                 135                 140                 


Tyr Thr Pro Gly Gln Ile Gln Leu Gln Arg Leu Lys Glu Asn Asn Arg 
145                 150                 155                 160 


Val Lys Thr Gly Ile Asn Ala Gln Gly Asn Tyr Gln Leu Asn Val Phe 
                165                 170                 175     


Lys Val Ser Ala Tyr Ala Asn Glu Leu Ala Thr Ile Leu Lys Thr Gln 
            180                 185                 190         


Gln Ala Phe Tyr Pro Asn Glu Leu Thr Asp Asp Trp Ile Ala Leu Phe 
        195                 200                 205             


Val Gln Pro Gly Ile Ala Glu Glu Ala Gly Leu Ile Tyr Arg Lys Arg 
    210                 215                 220                 


Pro Tyr Tyr His Gly Pro Gly Asn Glu Ala Asn Asn Ser Pro Tyr Gly 
225                 230                 235                 240 


Arg Trp Ser Asp Phe Lys Lys Thr Gly Gln Pro Ala Thr Asn Ile Phe 
                245                 250                 255     


Asp Arg Leu Ile Gly Lys Asp Phe Gln Gly Glu Leu Arg Ala Ser Gly 
            260                 265                 270         


Leu Ser Leu Ser Ala Gln Gln Tyr Asn Leu Leu Asn Asp Leu Thr Asn 
        275                 280                 285             


Leu Lys Ile Asp Gly Glu Ile Pro Leu Ser Pro Glu Gln Lys Glu Tyr 
    290                 295                 300                 


Ile Leu Ala Glu Leu Met Thr Lys Glu Phe Thr Arg Phe Gly Val Asn 
305                 310                 315                 320 


Asp Val Ala Lys Leu Leu Gly Val Lys Lys Glu Arg Leu Ser Gly Trp 
                325                 330                 335     


Arg Leu Asp Lys Lys Gly Lys Pro Glu Ile His Thr Leu Lys Gly Tyr 
            340                 345                 350         


Arg Asn Trp Arg Lys Ile Phe Ala Glu Ser Gly Ile Asp Leu Ala Thr 
        355                 360                 365             


Leu Pro Thr Glu Thr Ile Asp Cys Leu Ala Lys Val Leu Thr Leu Asn 
    370                 375                 380                 


Thr Glu His Glu Gly Ile Glu Asn Thr Leu Ala Phe Glu Leu Pro Glu 
385                 390                 395                 400 


Leu Ala Glu Ser Val Lys Leu Leu Val Leu Asp Arg Tyr Lys Glu Leu 
                405                 410                 415     


Ser Gln Ser Val Ser Thr Gln Ala Trp His Arg Phe Ser Leu Lys Thr 
            420                 425                 430         


Leu His Leu Leu Ile Pro Glu Leu Met Asn Ala Thr Ser Glu Gln Asn 
        435                 440                 445             


Thr Leu Leu Glu Gln Phe Gln Leu Lys Ser Asp Val Arg Lys Arg Tyr 
    450                 455                 460                 


Ser Glu Tyr Lys Lys Leu Pro Thr Lys Asp Val Leu Thr Glu Ile Tyr 
465                 470                 475                 480 


Asn Pro Thr Val Asn Lys Thr Val Ser Gln Ala Phe Lys Val Ile Asp 
                485                 490                 495     


Ala Leu Leu Val Lys Tyr Gly Lys Glu Gln Ile Arg Tyr Ile Thr Ile 
            500                 505                 510         


Glu Met Pro Arg Asp Asp Asn Glu Glu Asp Glu Lys Lys Arg Ile Lys 
        515                 520                 525             


Glu Leu His Ala Lys Asn Ser Gln Arg Lys Asn Asp Ser Gln Ser Tyr 
    530                 535                 540                 


Phe Met Gln Lys Ser Gly Trp Ser Gln Glu Lys Phe Gln Thr Thr Ile 
545                 550                 555                 560 


Gln Lys Asn Arg Arg Phe Leu Ala Lys Leu Leu Tyr Tyr Tyr Glu Gln 
                565                 570                 575     


Asp Gly Ile Cys Ala Tyr Thr Gly Leu Ser Ile Ser Pro Glu Leu Leu 
            580                 585                 590         


Val Ser Asp Ser Thr Glu Ile Asp His Ile Ile Pro Ile Ser Ile Ser 
        595                 600                 605             


Leu Asp Asp Ser Ile Asn Asn Lys Val Leu Val Leu Ser Lys Ala Asn 
    610                 615                 620                 


Gln Val Lys Gly Gln Gln Thr Pro Tyr Asp Ala Trp Met Asp Gly Ser 
625                 630                 635                 640 


Phe Lys Lys Ile Asn Gly Lys Phe Ser Asn Trp Asp Asp Tyr Gln Lys 
                645                 650                 655     


Trp Val Glu Ser Arg His Phe Ser His Lys Lys Glu Asn Asn Leu Leu 
            660                 665                 670         


Glu Thr Arg Asn Ile Phe Asp Ser Glu Gln Val Glu Lys Phe Leu Ala 
        675                 680                 685             


Arg Asn Leu Asn Asp Thr Arg Tyr Ala Ser Arg Leu Val Leu Asn Thr 
    690                 695                 700                 


Leu Gln Ser Phe Phe Ala Asn His Glu Thr Lys Val Arg Val Val Asn 
705                 710                 715                 720 


Gly Ser Phe Thr His Thr Leu Arg Lys Lys Trp Gly Ala Asp Leu Asp 
                725                 730                 735     


Lys Thr Arg Glu Thr His His His His Ala Val Asp Ala Thr Leu Cys 
            740                 745                 750         


Ala Val Thr Pro Phe Val Lys Val Ser Arg Tyr His Tyr Ala Val Lys 
        755                 760                 765             


Glu Glu Thr Gly Glu Lys Val Met Arg Glu Ile Asp Phe Glu Thr Gly 
    770                 775                 780                 


Glu Ile Val Asp Glu Met Ser Tyr Gln Glu Phe Lys Lys Ser Lys Lys 
785                 790                 795                 800 


Tyr Glu Arg Lys Thr Tyr Gln Val Lys Trp Pro Asn Phe Arg Glu Gln 
                805                 810                 815     


Leu Lys Pro Val Asn Leu His Pro Arg Ile Lys Phe Ser His Gln Val 
            820                 825                 830         


Asp Arg Lys Ala Asn Arg Lys Leu Ser Asp Ala Thr Ile Tyr Ser Val 
        835                 840                 845             


Arg Glu Lys Thr Glu Val Lys Thr Leu Lys Ser Gly Lys Gln Lys Ile 
    850                 855                 860                 


Thr Thr Asp Glu Tyr Thr Ile Gly Lys Ile Lys Asp Ile Tyr Thr Val 
865                 870                 875                 880 


Asp Gly Trp Glu Ala Phe Lys Lys Lys Gln Asp Lys Leu Leu Met Lys 
                885                 890                 895     


Asp Leu Asp Glu Lys Thr Tyr Glu Arg Leu Leu Ser Ile Ala Glu Thr 
            900                 905                 910         


Thr Pro Asp Phe Gln Glu Val Glu Glu Lys Asn Gly Lys Val Lys Arg 
        915                 920                 925             


Val Lys Arg Ser Pro Phe Ala Val Tyr Cys Glu Glu Asn Asp Ile Pro 
    930                 935                 940                 


Ala Ile Gln Lys Tyr Ala Lys Lys Asn Asn Gly Pro Leu Ile Arg Ser 
945                 950                 955                 960 


Leu Lys Tyr Tyr Asp Gly Lys Leu Asn Lys His Ile Asn Ile Thr Lys 
                965                 970                 975     


Asp Ser Gln Gly Arg Pro Val Glu Lys Thr Lys Asn Gly Arg Lys Val 
            980                 985                 990         


Thr Leu Gln Ser Leu Lys Pro Tyr  Arg Tyr Asp Ile Tyr  Gln Asp Leu 
        995                 1000                 1005             


Glu Thr  Lys Ala Tyr Tyr Thr  Val Gln Leu Tyr Tyr  Ser Asp Leu 
    1010                 1015                 1020             


Arg Phe  Val Glu Gly Lys Tyr  Gly Ile Thr Glu Lys  Glu Tyr Met 
    1025                 1030                 1035             


Lys Lys  Val Ala Glu Gln Thr  Lys Gly Gln Val Val  Arg Phe Cys 
    1040                 1045                 1050             


Phe Ser  Leu Gln Lys Asn Asp  Gly Leu Glu Ile Glu  Trp Lys Asp 
    1055                 1060                 1065             


Ser Gln  Arg Tyr Asp Val Arg  Phe Tyr Asn Phe Gln  Ser Ala Asn 
    1070                 1075                 1080             


Ser Ile  Asn Phe Lys Gly Leu  Glu Gln Glu Met Met  Pro Ala Glu 
    1085                 1090                 1095             


Asn Gln  Phe Lys Gln Lys Pro  Tyr Asn Asn Gly Ala  Ile Asn Leu 
    1100                 1105                 1110             


Asn Ile  Ala Lys Tyr Gly Lys  Glu Gly Lys Lys Leu  Arg Lys Phe 
    1115                 1120                 1125             


Asn Thr  Asp Ile Leu Gly Lys  Lys His Tyr Leu Tyr  Tyr Glu Lys 
    1130                 1135                 1140             


Glu Pro  Lys Asn Ile Ile Lys  
    1145                 1150 


<210> 192
<211> 1337
<212> PRT
<213> Enterococcus faecalis

<400> 192
Met Lys Lys Asp Tyr Val Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Met Thr Glu Asp Tyr Gln Leu Val Lys Lys Lys Met 
            20                  25                  30          


Pro Ile Tyr Gly Asn Thr Glu Lys Lys Lys Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Glu Glu Gly His Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Ile Ser Arg Arg Arg Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Ala Phe Phe Glu Glu Ala Met Thr Asp Leu Asp Glu Asn 
                85                  90                  95      


Phe Phe Ala Arg Leu Gln Glu Ser Phe Leu Val Pro Glu Asp Lys Lys 
            100                 105                 110         


Trp His Arg His Pro Ile Phe Ala Lys Leu Glu Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Gln Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Val Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Ser Thr 
                165                 170                 175     


Glu Asn Ile Ser Val Lys Glu Gln Phe Gln Gln Phe Met Ile Ile Tyr 
            180                 185                 190         


Asn Gln Thr Phe Val Asn Gly Glu Ser Arg Leu Val Ser Ala Pro Leu 
        195                 200                 205             


Pro Glu Ser Val Leu Ile Glu Glu Glu Leu Thr Glu Lys Ala Ser Arg 
    210                 215                 220                 


Thr Lys Lys Ser Glu Lys Val Leu Gln Gln Phe Pro Gln Glu Lys Ala 
225                 230                 235                 240 


Asn Gly Leu Phe Gly Gln Phe Leu Lys Leu Met Val Gly Asn Lys Ala 
                245                 250                 255     


Asp Phe Lys Lys Val Phe Gly Leu Glu Glu Glu Ala Lys Ile Thr Tyr 
            260                 265                 270         


Ala Ser Glu Ser Tyr Glu Glu Asp Leu Glu Gly Ile Leu Ala Lys Val 
        275                 280                 285             


Gly Asp Glu Tyr Ser Asp Val Phe Leu Ala Ala Lys Asn Val Tyr Asp 
    290                 295                 300                 


Ala Val Glu Leu Ser Thr Ile Leu Ala Asp Ser Asp Lys Lys Ser His 
305                 310                 315                 320 


Ala Lys Leu Ser Ser Ser Met Ile Val Arg Phe Thr Glu His Gln Glu 
                325                 330                 335     


Asp Leu Lys Lys Phe Lys Arg Phe Ile Arg Glu Asn Cys Pro Asp Glu 
            340                 345                 350         


Tyr Asp Asn Leu Phe Lys Asn Glu Gln Lys Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Ala His Ala Gly Lys Val Ser Gln Leu Lys Phe Tyr Gln Tyr Val 
    370                 375                 380                 


Lys Lys Ile Ile Gln Asp Ile Ala Gly Ala Glu Tyr Phe Leu Glu Lys 
385                 390                 395                 400 


Ile Ala Gln Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
                405                 410                 415     


Val Ile Pro His Gln Ile His Leu Ala Glu Leu Gln Ala Ile Ile His 
            420                 425                 430         


Arg Gln Ala Ala Tyr Tyr Pro Phe Leu Lys Glu Asn Gln Glu Lys Ile 
        435                 440                 445             


Glu Gln Leu Val Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ser 
    450                 455                 460                 


Lys Gly Asp Ala Ser Thr Phe Ala Trp Leu Lys Arg Gln Ser Glu Glu 
465                 470                 475                 480 


Pro Ile Arg Pro Trp Asn Leu Gln Glu Thr Val Asp Leu Asp Gln Ser 
                485                 490                 495     


Ala Thr Ala Phe Ile Glu Arg Met Thr Asn Phe Asp Thr Tyr Leu Pro 
            500                 505                 510         


Ser Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys Phe Met 
        515                 520                 525             


Val Phe Asn Glu Leu Thr Lys Ile Ser Tyr Thr Asp Asp Arg Gly Ile 
    530                 535                 540                 


Lys Ala Asn Phe Ser Gly Lys Glu Lys Glu Lys Ile Phe Asp Tyr Leu 
545                 550                 555                 560 


Phe Lys Thr Arg Arg Lys Val Lys Lys Lys Asp Ile Ile Gln Phe Tyr 
                565                 570                 575     


Arg Asn Glu Tyr Asn Thr Glu Ile Val Thr Leu Ser Gly Leu Glu Glu 
            580                 585                 590         


Asp Gln Phe Asn Ala Ser Phe Ser Thr Tyr Gln Asp Leu Leu Lys Cys 
        595                 600                 605             


Gly Leu Thr Arg Ala Glu Leu Asp His Pro Asp Asn Ala Glu Lys Leu 
    610                 615                 620                 


Glu Asp Ile Ile Lys Ile Leu Thr Ile Phe Glu Asp Arg Gln Arg Ile 
625                 630                 635                 640 


Arg Thr Gln Leu Ser Thr Phe Lys Gly Gln Phe Ser Ala Glu Val Leu 
                645                 650                 655     


Lys Lys Leu Glu Arg Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 
            660                 665                 670         


Lys Leu Ile Asn Gly Ile Tyr Asp Lys Glu Ser Gly Lys Thr Ile Leu 
        675                 680                 685             


Asp Tyr Leu Val Lys Asp Asp Gly Val Ser Lys His Tyr Asn Arg Asn 
    690                 695                 700                 


Phe Met Gln Leu Ile Asn Asp Ser Gln Leu Ser Phe Lys Asn Ala Ile 
705                 710                 715                 720 


Gln Lys Ala Gln Ser Ser Glu His Glu Glu Thr Leu Ser Glu Thr Val 
                725                 730                 735     


Asn Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Tyr Gln Ser 
            740                 745                 750         


Leu Lys Ile Val Asp Glu Leu Val Ala Ile Met Gly Tyr Ala Pro Lys 
        755                 760                 765             


Arg Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Ser Thr Gly 
    770                 775                 780                 


Lys Arg Arg Ser Ile Gln Arg Leu Lys Ile Val Glu Lys Ala Met Ala 
785                 790                 795                 800 


Glu Ile Gly Ser Asn Leu Leu Lys Glu Gln Pro Thr Thr Asn Glu Gln 
                805                 810                 815     


Leu Arg Asp Thr Arg Leu Phe Leu Tyr Tyr Met Gln Asn Gly Lys Asp 
            820                 825                 830         


Met Tyr Thr Gly Asp Glu Leu Ser Leu His Arg Leu Ser His Tyr Asp 
        835                 840                 845             


Ile Asp His Ile Ile Pro Gln Ser Phe Met Lys Asp Asp Ser Leu Asp 
    850                 855                 860                 


Asn Leu Val Leu Val Gly Ser Thr Glu Asn Arg Gly Lys Ser Asp Asp 
865                 870                 875                 880 


Val Pro Ser Lys Glu Val Val Lys Asp Met Lys Ala Tyr Trp Glu Lys 
                885                 890                 895     


Leu Tyr Ala Ala Gly Leu Ile Ser Gln Arg Lys Phe Gln Arg Leu Thr 
            900                 905                 910         


Lys Gly Glu Gln Gly Gly Leu Thr Leu Glu Asp Lys Ala His Phe Ile 
        915                 920                 925             


Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys Asn Val Ala Gly 
    930                 935                 940                 


Ile Leu Asn Gln Arg Tyr Asn Ala Asn Ser Lys Glu Lys Lys Val Gln 
945                 950                 955                 960 


Ile Ile Thr Leu Lys Ala Ser Leu Thr Ser Gln Phe Arg Ser Ile Phe 
                965                 970                 975     


Gly Leu Tyr Lys Val Arg Glu Val Asn Asp Tyr His His Gly Gln Asp 
            980                 985                 990         


Ala Tyr Leu Asn Cys Val Val Ala  Thr Thr Leu Leu Lys  Val Tyr Pro 
        995                 1000                 1005             


Asn Leu  Ala Pro Glu Phe Val  Tyr Gly Glu Tyr Pro  Lys Phe Gln 
    1010                 1015                 1020             


Thr Phe  Lys Glu Asn Lys Ala  Thr Ala Lys Ala Ile  Ile Tyr Thr 
    1025                 1030                 1035             


Asn Leu  Leu Arg Phe Phe Thr  Glu Asp Glu Pro Arg  Phe Thr Lys 
    1040                 1045                 1050             


Asp Gly  Glu Ile Leu Trp Ser  Asn Ser Tyr Leu Lys  Thr Ile Lys 
    1055                 1060                 1065             


Lys Glu  Leu Asn Tyr His Gln  Met Asn Ile Val Lys  Lys Val Glu 
    1070                 1075                 1080             


Val Gln  Lys Gly Gly Phe Ser  Lys Glu Ser Ile Lys  Pro Lys Gly 
    1085                 1090                 1095             


Pro Ser  Asn Lys Leu Ile Pro  Val Lys Asn Gly Leu  Asp Pro Gln 
    1100                 1105                 1110             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Val Val Ala Tyr  Thr Val Leu 
    1115                 1120                 1125             


Phe Thr  His Glu Lys Gly Lys  Lys Pro Leu Ile Lys  Gln Glu Ile 
    1130                 1135                 1140             


Leu Gly  Ile Thr Ile Met Glu  Lys Thr Arg Phe Glu  Gln Asn Pro 
    1145                 1150                 1155             


Ile Leu  Phe Leu Glu Glu Lys  Gly Phe Leu Arg Pro  Arg Val Leu 
    1160                 1165                 1170             


Met Lys  Leu Pro Lys Tyr Thr  Leu Tyr Glu Phe Pro  Glu Gly Arg 
    1175                 1180                 1185             


Arg Arg  Leu Leu Ala Ser Ala  Lys Glu Ala Gln Lys  Gly Asn Gln 
    1190                 1195                 1200             


Met Val  Leu Pro Glu His Leu  Leu Thr Leu Leu Tyr  His Ala Lys 
    1205                 1210                 1215             


Gln Cys  Leu Leu Pro Asn Gln  Ser Glu Ser Leu Ala  Tyr Val Glu 
    1220                 1225                 1230             


Gln His  Gln Pro Glu Phe Gln  Glu Ile Leu Glu Arg  Val Val Asp 
    1235                 1240                 1245             


Phe Ala  Glu Val His Thr Leu  Ala Lys Ser Lys Val  Gln Gln Ile 
    1250                 1255                 1260             


Val Lys  Leu Phe Glu Ala Asn  Gln Thr Ala Asp Val  Lys Glu Ile 
    1265                 1270                 1275             


Ala Ala  Ser Phe Ile Gln Leu  Met Gln Phe Asn Ala  Met Gly Ala 
    1280                 1285                 1290             


Pro Ser  Thr Phe Lys Phe Phe  Gln Lys Asp Ile Glu  Arg Ala Arg 
    1295                 1300                 1305             


Tyr Thr  Ser Ile Lys Glu Ile  Phe Asp Ala Thr Ile  Ile Tyr Gln 
    1310                 1315                 1320             


Ser Thr  Thr Gly Leu Tyr Glu  Thr Arg Arg Lys Val  Val Asp 
    1325                 1330                 1335         


<210> 193
<211> 1150
<212> PRT
<213> Enterococcus faecalis


<220>
<223> Enterococcus faecalis R508

<400> 193
Met Tyr Ser Ile Gly Leu Asp Leu Gly Ile Ser Ser Val Gly Trp Ser 
1               5                   10                  15      


Val Ile Asp Glu Arg Thr Gly Asn Val Ile Asp Leu Gly Val Arg Leu 
            20                  25                  30          


Phe Ser Ala Lys Asn Ser Glu Lys Asn Leu Glu Arg Arg Thr Asn Arg 
        35                  40                  45              


Gly Gly Arg Arg Leu Ile Arg Arg Lys Thr Asn Arg Leu Lys Asp Ala 
    50                  55                  60                  


Lys Lys Ile Leu Ala Ala Val Gly Phe Tyr Glu Asp Lys Ser Leu Lys 
65                  70                  75                  80  


Asn Ser Cys Pro Tyr Gln Leu Arg Val Lys Gly Leu Thr Glu Pro Leu 
                85                  90                  95      


Ser Lys Gly Glu Ile Tyr Lys Val Thr Leu His Ile Leu Lys Lys Arg 
            100                 105                 110         


Gly Ile Ser Tyr Leu Asp Glu Asp Asp Thr Glu Ala Ala Lys Glu Ser 
        115                 120                 125             


Gln Asp Tyr Lys Glu Gln Val Arg Lys Asn Ala Gln Leu Leu Thr Lys 
    130                 135                 140                 


Tyr Thr Pro Gly Gln Ile Gln Leu Gln Arg Leu Lys Glu Asn Asn Arg 
145                 150                 155                 160 


Val Lys Thr Gly Ile Asn Val Gln Gly Asn Tyr Gln Leu Asn Val Phe 
                165                 170                 175     


Lys Val Ser Ala Tyr Ala Asn Glu Leu Ala Thr Ile Leu Lys Thr Gln 
            180                 185                 190         


Gln Ala Phe Tyr Pro Asn Glu Leu Thr Asp Asp Trp Ile Ala Leu Phe 
        195                 200                 205             


Val Gln Pro Gly Ile Ala Glu Glu Ala Gly Leu Ile Tyr Arg Lys Arg 
    210                 215                 220                 


Pro Tyr Tyr His Gly Pro Gly Asn Glu Ala Asn Asn Ser Pro Tyr Gly 
225                 230                 235                 240 


Arg Trp Ser Asp Phe Gln Lys Thr Gly Glu Pro Ala Thr Asn Ile Phe 
                245                 250                 255     


Asp Lys Leu Ile Gly Lys Asp Phe Gln Gly Glu Leu Arg Ala Ser Gly 
            260                 265                 270         


Leu Ser Leu Ser Ala Gln Gln Tyr Asn Leu Leu Asn Asp Leu Thr Asn 
        275                 280                 285             


Leu Lys Ile Asp Gly Glu Val Pro Leu Ser Ser Glu Gln Lys Glu Tyr 
    290                 295                 300                 


Ile Leu Thr Glu Leu Met Thr Lys Glu Phe Thr Arg Phe Gly Val Asn 
305                 310                 315                 320 


Asp Val Val Lys Leu Leu Gly Val Lys Lys Glu Arg Leu Ser Gly Trp 
                325                 330                 335     


Arg Leu Asp Lys Lys Gly Lys Pro Glu Ile His Thr Leu Lys Gly Tyr 
            340                 345                 350         


Arg Asn Trp Arg Lys Ile Phe Ala Glu Ala Gly Ile Asp Leu Ala Thr 
        355                 360                 365             


Leu Pro Thr Glu Thr Ile Asp Cys Leu Ala Lys Val Leu Thr Leu Asn 
    370                 375                 380                 


Thr Glu Arg Glu Gly Ile Glu Asn Thr Leu Ala Phe Glu Leu Pro Glu 
385                 390                 395                 400 


Leu Ser Glu Ser Val Lys Leu Leu Val Leu Asp Arg Tyr Lys Glu Leu 
                405                 410                 415     


Ser Gln Ser Ile Ser Thr Gln Ser Trp His Arg Phe Ser Leu Lys Thr 
            420                 425                 430         


Leu His Leu Leu Ile Pro Glu Leu Met Asn Ala Thr Ser Glu Gln Asn 
        435                 440                 445             


Thr Leu Leu Glu Gln Phe Gln Leu Lys Ser Asp Val Arg Lys Arg Tyr 
    450                 455                 460                 


Ser Glu Tyr Lys Lys Leu Pro Thr Lys Asp Val Leu Ala Glu Ile Tyr 
465                 470                 475                 480 


Asn Pro Thr Val Asn Lys Thr Val Ser Gln Ala Phe Lys Val Ile Asp 
                485                 490                 495     


Ala Leu Leu Val Lys Tyr Gly Lys Glu Gln Ile Arg Tyr Ile Thr Ile 
            500                 505                 510         


Glu Met Pro Arg Asp Asp Asn Glu Glu Asp Glu Lys Lys Arg Ile Lys 
        515                 520                 525             


Glu Leu His Ala Lys Asn Ser Gln Arg Lys Asn Asp Ser Gln Ser Tyr 
    530                 535                 540                 


Phe Met Gln Lys Ser Gly Trp Ser Gln Glu Lys Phe Gln Thr Thr Ile 
545                 550                 555                 560 


Gln Lys Asn Arg Arg Phe Leu Ala Lys Leu Leu Tyr Tyr Tyr Glu Gln 
                565                 570                 575     


Asp Gly Ile Cys Ala Tyr Thr Gly Leu Pro Ile Ser Pro Glu Leu Leu 
            580                 585                 590         


Val Ser Asp Ser Thr Glu Ile Asp His Ile Ile Pro Ile Ser Ile Ser 
        595                 600                 605             


Leu Asp Asp Ser Ile Asn Asn Lys Val Leu Val Leu Ser Lys Ala Asn 
    610                 615                 620                 


Gln Val Lys Gly Gln Gln Thr Pro Tyr Asp Ala Trp Met Asp Gly Ser 
625                 630                 635                 640 


Phe Lys Lys Ile Asn Gly Lys Phe Ser Asn Trp Asp Asp Tyr Gln Lys 
                645                 650                 655     


Trp Val Glu Ser Arg His Phe Ser His Lys Lys Glu Asn Asn Leu Leu 
            660                 665                 670         


Glu Thr Arg Asn Ile Phe Asp Ser Glu Gln Val Glu Lys Phe Leu Ala 
        675                 680                 685             


Arg Asn Leu Asn Asp Thr Arg Tyr Ala Ser Arg Leu Val Leu Asn Thr 
    690                 695                 700                 


Leu Gln Ser Phe Phe Thr Asn Gln Glu Thr Lys Val Arg Val Val Asn 
705                 710                 715                 720 


Gly Ser Phe Thr His Thr Leu Arg Lys Lys Trp Gly Ala Asp Leu Asp 
                725                 730                 735     


Lys Thr Arg Glu Thr His His His His Ala Val Asp Ala Thr Leu Cys 
            740                 745                 750         


Ala Val Thr Pro Phe Val Lys Val Ser Arg Tyr His Tyr Ala Val Lys 
        755                 760                 765             


Glu Glu Thr Gly Glu Lys Val Met Arg Glu Ile Asp Phe Glu Thr Gly 
    770                 775                 780                 


Glu Ile Val Asn Glu Met Ser Tyr Arg Glu Phe Lys Lys Ser Lys Lys 
785                 790                 795                 800 


Tyr Glu Arg Lys Thr Tyr Gln Val Lys Trp Pro Asn Phe Arg Glu Gln 
                805                 810                 815     


Leu Lys Pro Val Asn Leu His Pro Arg Ile Lys Phe Ser His Gln Val 
            820                 825                 830         


Asp Arg Lys Ala Asn Arg Lys Leu Ser Asp Ala Thr Ile Tyr Ser Val 
        835                 840                 845             


Arg Glu Lys Thr Glu Val Lys Thr Leu Lys Ser Gly Lys Gln Lys Ile 
    850                 855                 860                 


Thr Thr Asp Glu Tyr Thr Ile Gly Lys Ile Lys Asp Ile Tyr Thr Leu 
865                 870                 875                 880 


Asp Gly Trp Glu Ala Phe Lys Lys Lys Gln Asp Lys Leu Leu Met Lys 
                885                 890                 895     


Asp Leu Asp Glu Lys Thr Tyr Glu Arg Leu Leu Ser Ile Ala Glu Thr 
            900                 905                 910         


Thr Pro Asp Phe Gln Glu Val Glu Glu Lys Asn Gly Lys Val Lys Arg 
        915                 920                 925             


Val Lys Arg Ser Pro Phe Ala Val Tyr Cys Glu Glu Asn Asp Ile Pro 
    930                 935                 940                 


Ala Ile Gln Lys Tyr Ala Lys Lys Asn Asn Gly Pro Leu Ile Arg Ser 
945                 950                 955                 960 


Leu Lys Tyr Tyr Asp Gly Lys Leu Asn Lys His Ile Asn Ile Thr Lys 
                965                 970                 975     


Asp Ser Gln Gly Arg Pro Val Glu Lys Thr Lys Asn Gly Arg Lys Val 
            980                 985                 990         


Thr Leu Gln Ser Leu Lys Pro Tyr  Arg Tyr Asp Ile Tyr  Gln Asp Leu 
        995                 1000                 1005             


Glu Thr  Lys Ala Tyr Tyr Thr  Val Gln Leu Tyr Tyr  Ser Asp Leu 
    1010                 1015                 1020             


Arg Phe  Val Glu Gly Lys Tyr  Gly Ile Thr Glu Lys  Glu Tyr Met 
    1025                 1030                 1035             


Lys Lys  Val Ala Glu Gln Thr  Lys Gly Gln Val Val  Arg Phe Cys 
    1040                 1045                 1050             


Phe Ser  Leu Gln Lys Asn Asp  Gly Leu Glu Ile Glu  Trp Lys Asp 
    1055                 1060                 1065             


Ser Gln  Arg Tyr Asp Val Arg  Phe Tyr Asn Phe Gln  Ser Ala Asn 
    1070                 1075                 1080             


Ser Ile  Asn Phe Lys Gly Leu  Glu Gln Glu Ile Met  Pro Ala Glu 
    1085                 1090                 1095             


Asn Gln  Phe Lys Gln Lys Pro  Tyr Asn Asn Gly Ala  Ile Asn Leu 
    1100                 1105                 1110             


Asn Ile  Ala Lys Tyr Gly Lys  Glu Gly Lys Lys Leu  Arg Lys Phe 
    1115                 1120                 1125             


Asn Thr  Asp Ile Leu Gly Lys  Lys His Tyr Leu Phe  Tyr Glu Lys 
    1130                 1135                 1140             


Glu Pro  Lys Asn Ile Ile Lys  
    1145                 1150 


<210> 194
<211> 1150
<212> PRT
<213> Enterococcus faecalis


<220>
<223> Enterococcus faecalis T11

<400> 194
Met Tyr Ser Ile Gly Leu Asp Leu Gly Ile Ser Ser Val Gly Trp Ser 
1               5                   10                  15      


Val Ile Asp Glu Arg Thr Gly Asn Val Ile Asp Leu Gly Val Arg Leu 
            20                  25                  30          


Phe Ser Ala Lys Asn Ser Glu Lys Asn Leu Glu Arg Arg Thr Asn Arg 
        35                  40                  45              


Gly Gly Arg Arg Leu Ile Arg Arg Lys Thr Asn Arg Leu Lys Asp Ala 
    50                  55                  60                  


Lys Lys Ile Leu Ala Ala Val Gly Phe Tyr Glu Asp Lys Ser Leu Lys 
65                  70                  75                  80  


Asn Ser Cys Pro Tyr Gln Leu Arg Val Lys Gly Leu Thr Glu Pro Leu 
                85                  90                  95      


Ser Lys Gly Glu Ile Tyr Lys Val Thr Leu His Ile Leu Lys Lys Arg 
            100                 105                 110         


Gly Ile Ser Tyr Leu Asp Glu Asp Asp Thr Glu Ala Ala Lys Glu Ser 
        115                 120                 125             


Gln Asp Tyr Lys Glu Gln Val Arg Glu Asn Ala Gln Leu Leu Thr Lys 
    130                 135                 140                 


Tyr Thr Pro Gly Gln Ile Gln Leu Gln Arg Leu Lys Glu Asn Asn Arg 
145                 150                 155                 160 


Val Lys Thr Gly Ile Asn Ala Gln Gly Asn Tyr Gln Leu Asn Val Phe 
                165                 170                 175     


Lys Val Ser Ala Tyr Ala Asn Glu Leu Ala Thr Ile Leu Lys Thr Gln 
            180                 185                 190         


Gln Ala Phe Tyr Pro Asn Glu Leu Thr Asp Asp Trp Ile Ala Leu Phe 
        195                 200                 205             


Val Gln Pro Gly Ile Ala Glu Glu Ala Gly Leu Ile Tyr Arg Lys Arg 
    210                 215                 220                 


Pro Tyr Tyr His Gly Pro Gly Asn Glu Ala Asn Asn Ser Pro Tyr Gly 
225                 230                 235                 240 


Arg Trp Ser Asp Phe Lys Lys Thr Gly Gln Pro Ala Thr Asn Ile Phe 
                245                 250                 255     


Asp Lys Leu Ile Gly Lys Asp Phe Gln Gly Glu Leu Arg Ala Ser Gly 
            260                 265                 270         


Leu Ser Leu Ser Ala Gln Gln Tyr Asn Leu Leu Asn Asp Leu Thr Asn 
        275                 280                 285             


Leu Lys Ile Asp Gly Glu Ile Pro Leu Ser Pro Glu Gln Lys Glu Tyr 
    290                 295                 300                 


Ile Leu Ala Glu Leu Met Thr Lys Glu Phe Thr Arg Phe Gly Val Asn 
305                 310                 315                 320 


Asp Val Val Lys Leu Leu Gly Val Lys Lys Glu Arg Leu Ser Gly Trp 
                325                 330                 335     


Arg Leu Asp Lys Lys Gly Lys Pro Glu Ile His Thr Leu Lys Gly Tyr 
            340                 345                 350         


Arg Asn Trp Arg Lys Ile Phe Ala Glu Ser Gly Ile Asp Leu Ala Met 
        355                 360                 365             


Leu Pro Thr Glu Thr Ile Asp Cys Leu Ala Lys Ile Leu Thr Leu Asn 
    370                 375                 380                 


Thr Glu Arg Glu Gly Ile Glu Asn Thr Leu Ala Phe Glu Leu Pro Glu 
385                 390                 395                 400 


Leu Ala Glu Ser Val Lys Leu Leu Val Leu Asp Arg Tyr Lys Glu Leu 
                405                 410                 415     


Ser Gln Ser Val Ser Thr Gln Ala Trp His Arg Phe Ser Leu Lys Thr 
            420                 425                 430         


Leu His Leu Leu Ile Pro Glu Leu Met Asn Ala Thr Ser Glu Gln Asn 
        435                 440                 445             


Thr Leu Leu Glu Gln Phe Gln Leu Lys Ser Asp Val Arg Lys Arg Tyr 
    450                 455                 460                 


Ser Glu Tyr Lys Lys Leu Pro Thr Lys Asp Val Leu Thr Glu Ile Tyr 
465                 470                 475                 480 


Asn Pro Thr Val Asn Lys Thr Val Ser Gln Ala Phe Lys Val Ile Asp 
                485                 490                 495     


Ala Leu Leu Val Lys Tyr Gly Lys Glu Gln Ile Arg Tyr Ile Thr Ile 
            500                 505                 510         


Glu Met Pro Arg Asp Asp Asn Glu Glu Asp Glu Lys Lys Arg Ile Lys 
        515                 520                 525             


Glu Leu His Ala Lys Asn Ser Gln Arg Lys Asn Asp Ser Gln Ser Tyr 
    530                 535                 540                 


Phe Met Gln Lys Ser Gly Trp Ser Gln Glu Lys Phe Gln Thr Thr Ile 
545                 550                 555                 560 


Gln Lys Asn Arg Arg Phe Leu Ala Lys Leu Leu Tyr Tyr Tyr Glu Gln 
                565                 570                 575     


Asp Gly Ile Cys Ala Tyr Thr Gly Leu Ser Ile Ser Pro Glu Leu Leu 
            580                 585                 590         


Val Ser Asp Ser Thr Glu Ile Asp His Ile Ile Pro Ile Ser Ile Ser 
        595                 600                 605             


Leu Asp Asp Ser Ile Asn Asn Lys Val Leu Val Leu Ser Lys Ala Asn 
    610                 615                 620                 


Gln Val Lys Gly Gln Gln Thr Pro Tyr Asp Ala Trp Met Asp Gly Ser 
625                 630                 635                 640 


Phe Lys Lys Ile Asn Gly Lys Phe Ser Asn Trp Asp Asp Tyr Gln Lys 
                645                 650                 655     


Trp Val Glu Ser Arg His Phe Ser His Lys Lys Glu Asn Asn Leu Leu 
            660                 665                 670         


Glu Thr Arg Asn Ile Phe Asp Ser Glu Gln Val Glu Lys Phe Leu Ala 
        675                 680                 685             


Arg Asn Leu Asn Asp Thr Arg Tyr Ala Ser Arg Leu Val Leu Asn Thr 
    690                 695                 700                 


Leu Gln Ser Phe Phe Ala Asn Gln Glu Thr Lys Val Arg Val Val Asn 
705                 710                 715                 720 


Gly Ser Phe Thr His Thr Leu Arg Lys Lys Trp Gly Ala Asp Leu Asp 
                725                 730                 735     


Lys Thr Arg Glu Thr His His His His Ala Val Asp Ala Thr Leu Cys 
            740                 745                 750         


Ala Val Thr Pro Phe Val Lys Val Ser Arg Tyr His Tyr Ala Val Lys 
        755                 760                 765             


Glu Glu Thr Gly Glu Lys Val Met Arg Glu Ile Asp Phe Glu Thr Gly 
    770                 775                 780                 


Glu Ile Val Asp Glu Met Ser Tyr Arg Glu Phe Lys Lys Ser Lys Lys 
785                 790                 795                 800 


Tyr Glu Arg Lys Thr Tyr Gln Val Lys Trp Pro Asn Phe Arg Glu Gln 
                805                 810                 815     


Leu Lys Pro Val Asn Leu His Pro Arg Ile Lys Phe Ser His Gln Val 
            820                 825                 830         


Asp Arg Lys Ala Asn Arg Lys Leu Ser Asp Ala Thr Ile Tyr Ser Val 
        835                 840                 845             


Arg Glu Lys Thr Glu Val Lys Thr Leu Lys Ser Gly Lys Gln Lys Ile 
    850                 855                 860                 


Thr Thr Asp Glu Tyr Thr Ile Gly Lys Ile Lys Asp Ile Tyr Thr Val 
865                 870                 875                 880 


Asp Gly Trp Glu Ala Phe Lys Lys Lys Gln Asp Lys Leu Leu Met Lys 
                885                 890                 895     


Asp Leu Asp Glu Lys Thr Tyr Glu Arg Leu Leu Ser Ile Ala Glu Thr 
            900                 905                 910         


Thr Pro Asp Phe Gln Glu Val Glu Glu Lys Asn Gly Lys Val Lys Arg 
        915                 920                 925             


Val Lys Arg Ser Pro Phe Ala Val Tyr Cys Glu Glu Asn Asp Ile Pro 
    930                 935                 940                 


Ala Ile Arg Lys Tyr Ala Lys Lys Asn Asn Gly Pro Leu Ile Arg Ser 
945                 950                 955                 960 


Leu Lys Tyr Tyr Asp Gly Lys Leu Asn Lys His Ile Asn Ile Thr Lys 
                965                 970                 975     


Asp Ser Gln Gly Arg Pro Val Glu Lys Thr Lys Asn Gly Arg Lys Val 
            980                 985                 990         


Thr Leu Gln Ser Leu Lys Pro Tyr  Arg Tyr Asp Ile Tyr  Gln Asp Leu 
        995                 1000                 1005             


Glu Thr  Lys Ala Tyr Tyr Thr  Val Gln Leu Tyr Tyr  Ser Asp Leu 
    1010                 1015                 1020             


Arg Phe  Val Glu Gly Lys Tyr  Gly Ile Thr Glu Lys  Glu Tyr Met 
    1025                 1030                 1035             


Lys Lys  Val Ala Glu Gln Thr  Lys Gly Gln Val Val  Arg Phe Cys 
    1040                 1045                 1050             


Phe Ser  Leu Gln Lys Asn Asp  Gly Leu Glu Ile Glu  Trp Lys Asp 
    1055                 1060                 1065             


Ser Gln  Arg Tyr Asp Val Arg  Phe Tyr Asn Phe Gln  Ser Ala Asn 
    1070                 1075                 1080             


Ser Ile  Asn Phe Lys Gly Leu  Glu Gln Glu Met Met  Pro Ala Glu 
    1085                 1090                 1095             


Asn Gln  Phe Lys Gln Lys Pro  Tyr Asn Asn Gly Ala  Ile Asn Leu 
    1100                 1105                 1110             


Asn Ile  Ala Lys Tyr Gly Lys  Glu Gly Lys Lys Leu  Arg Lys Phe 
    1115                 1120                 1125             


Asn Thr  Asp Ile Leu Gly Lys  Lys His Tyr Leu Tyr  Tyr Glu Lys 
    1130                 1135                 1140             


Glu Pro  Lys Asn Ile Ile Lys  
    1145                 1150 


<210> 195
<211> 1150
<212> PRT
<213> Enterococcus faecalis


<220>
<223> Enterococcus faecalis TX0012

<400> 195
Met Tyr Ser Ile Gly Leu Asp Leu Gly Ile Ser Ser Val Gly Trp Ser 
1               5                   10                  15      


Val Ile Asp Glu Arg Thr Gly Asn Val Ile Asp Leu Gly Val Arg Leu 
            20                  25                  30          


Phe Ser Ala Lys Asn Ser Glu Lys Asn Leu Glu Arg Arg Thr Asn Arg 
        35                  40                  45              


Gly Gly Arg Arg Leu Ile Arg Arg Lys Thr Asn Arg Leu Lys Asp Ala 
    50                  55                  60                  


Lys Lys Ile Leu Ala Ala Val Gly Phe Tyr Glu Asp Lys Ser Leu Lys 
65                  70                  75                  80  


Asn Ser Cys Pro Tyr Gln Leu Arg Val Lys Gly Leu Thr Glu Pro Leu 
                85                  90                  95      


Ser Arg Gly Glu Ile Tyr Lys Val Thr Leu His Ile Leu Lys Lys Arg 
            100                 105                 110         


Gly Ile Ser Tyr Leu Asp Glu Val Asp Thr Glu Ala Ala Lys Glu Ser 
        115                 120                 125             


Gln Asp Tyr Lys Glu Gln Val Arg Lys Asn Ala Gln Leu Leu Thr Lys 
    130                 135                 140                 


Tyr Thr Pro Gly Gln Ile Gln Leu Gln Arg Leu Lys Glu Asn Asn Arg 
145                 150                 155                 160 


Val Lys Thr Gly Ile Asn Ala Gln Gly Asn Tyr Gln Leu Asn Val Phe 
                165                 170                 175     


Lys Val Ser Ala Tyr Ala Asn Glu Leu Ala Thr Ile Leu Lys Thr Gln 
            180                 185                 190         


Gln Ala Phe Tyr Pro Asn Glu Leu Thr Asp Asp Trp Ile Ala Leu Phe 
        195                 200                 205             


Val Gln Pro Gly Ile Ala Glu Glu Ala Gly Leu Ile Tyr Arg Lys Arg 
    210                 215                 220                 


Pro Tyr Tyr His Gly Pro Gly Asn Glu Ala Asn Asn Ser Pro Tyr Gly 
225                 230                 235                 240 


Arg Trp Ser Asp Phe Gln Lys Thr Gly Glu Pro Ala Thr Asn Ile Phe 
                245                 250                 255     


Asp Lys Leu Ile Gly Lys Asp Phe Gln Gly Glu Leu Arg Ala Ser Gly 
            260                 265                 270         


Leu Ser Leu Ser Ala Gln Gln Tyr Asn Leu Leu Asn Asp Leu Thr Asn 
        275                 280                 285             


Leu Lys Ile Asp Gly Glu Val Pro Leu Ser Ser Glu Gln Lys Glu Tyr 
    290                 295                 300                 


Ile Leu Thr Glu Leu Met Thr Lys Glu Phe Thr Arg Phe Gly Val Asn 
305                 310                 315                 320 


Asp Val Val Lys Leu Leu Gly Val Lys Lys Glu Arg Leu Ser Gly Trp 
                325                 330                 335     


Arg Leu Asp Lys Lys Gly Lys Pro Glu Ile His Thr Leu Lys Gly Tyr 
            340                 345                 350         


Arg Asn Trp Arg Lys Ile Phe Ala Glu Ala Gly Ile Asp Leu Ala Thr 
        355                 360                 365             


Leu Pro Thr Glu Thr Ile Asp Cys Leu Ala Lys Val Leu Thr Leu Asn 
    370                 375                 380                 


Thr Glu Arg Glu Gly Ile Glu Asn Thr Leu Ala Phe Glu Leu Pro Glu 
385                 390                 395                 400 


Leu Ser Glu Ser Val Lys Leu Leu Val Leu Asp Arg Tyr Lys Glu Leu 
                405                 410                 415     


Ser Gln Ser Ile Ser Thr Gln Ser Trp His Arg Phe Ser Leu Lys Thr 
            420                 425                 430         


Leu His Leu Leu Ile Pro Glu Leu Met Asn Ala Thr Ser Glu Gln Asn 
        435                 440                 445             


Thr Leu Leu Glu Gln Phe Gln Leu Lys Ser Asp Val Arg Lys Arg Tyr 
    450                 455                 460                 


Ser Glu Tyr Lys Lys Leu Pro Thr Lys Asp Val Leu Ala Glu Ile Tyr 
465                 470                 475                 480 


Asn Pro Thr Val Asn Lys Thr Val Ser Gln Ala Phe Lys Val Ile Asp 
                485                 490                 495     


Ala Leu Leu Val Lys Tyr Gly Lys Glu Gln Ile Arg Tyr Ile Thr Ile 
            500                 505                 510         


Glu Met Pro Arg Asp Asp Asn Glu Glu Asp Glu Lys Lys Arg Ile Lys 
        515                 520                 525             


Glu Leu His Ala Lys Asn Ser Gln Arg Lys Asn Asp Ser Gln Ser Tyr 
    530                 535                 540                 


Phe Met Gln Lys Ser Gly Trp Ser Gln Glu Lys Phe Gln Thr Thr Ile 
545                 550                 555                 560 


Gln Lys Asn Arg Arg Phe Leu Ala Lys Leu Leu Tyr Tyr Tyr Glu Gln 
                565                 570                 575     


Asp Gly Ile Cys Ala Tyr Thr Gly Leu Pro Ile Ser Pro Glu Leu Leu 
            580                 585                 590         


Val Ser Asp Ser Thr Glu Ile Asp His Ile Ile Pro Ile Ser Ile Ser 
        595                 600                 605             


Leu Asp Asp Ser Ile Asn Asn Lys Val Leu Val Leu Ser Lys Ala Asn 
    610                 615                 620                 


Gln Val Lys Gly Gln Gln Thr Pro Tyr Asp Ala Trp Met Asp Gly Ser 
625                 630                 635                 640 


Phe Lys Lys Ile Asn Gly Lys Phe Ser Asn Trp Asp Asp Tyr Gln Lys 
                645                 650                 655     


Trp Val Glu Ser Arg His Phe Ser His Lys Lys Glu Asn Asn Leu Leu 
            660                 665                 670         


Glu Thr Arg Asn Ile Phe Asp Ser Glu Gln Val Glu Lys Phe Leu Ala 
        675                 680                 685             


Arg Asn Leu Asn Asp Thr Arg Tyr Ala Ser Arg Leu Val Leu Asn Thr 
    690                 695                 700                 


Leu Gln Ser Phe Phe Thr Asn Gln Glu Thr Lys Val Arg Val Val Asn 
705                 710                 715                 720 


Gly Ser Phe Thr His Thr Leu Arg Lys Lys Trp Gly Ala Asp Leu Asp 
                725                 730                 735     


Lys Thr Arg Glu Thr His His His His Ala Val Asp Ala Thr Leu Cys 
            740                 745                 750         


Ala Val Thr Ser Phe Val Lys Val Ser Arg Tyr His Tyr Ala Val Lys 
        755                 760                 765             


Glu Glu Thr Gly Glu Lys Val Met Arg Glu Ile Asp Phe Glu Thr Gly 
    770                 775                 780                 


Glu Ile Val Asn Glu Met Ser Tyr Trp Glu Phe Lys Lys Ser Lys Lys 
785                 790                 795                 800 


Tyr Glu Arg Lys Thr Tyr Gln Val Lys Trp Pro Asn Phe Arg Glu Gln 
                805                 810                 815     


Leu Lys Pro Val Asn Leu His Pro Arg Ile Lys Phe Ser His Gln Val 
            820                 825                 830         


Asp Arg Lys Ala Asn Arg Lys Leu Ser Asp Ala Thr Ile Tyr Ser Val 
        835                 840                 845             


Arg Glu Lys Thr Glu Val Lys Thr Leu Lys Ser Gly Lys Gln Lys Ile 
    850                 855                 860                 


Thr Thr Asp Glu Tyr Thr Ile Gly Lys Ile Lys Asp Ile Tyr Thr Leu 
865                 870                 875                 880 


Asp Gly Trp Glu Ala Phe Lys Lys Lys Gln Asp Lys Leu Leu Met Lys 
                885                 890                 895     


Asp Leu Asp Glu Lys Thr Tyr Glu Arg Leu Leu Ser Ile Ala Glu Thr 
            900                 905                 910         


Thr Pro Asp Phe Gln Glu Val Glu Glu Lys Asn Gly Lys Val Lys Arg 
        915                 920                 925             


Val Lys Arg Ser Pro Phe Ala Val Tyr Cys Glu Glu Asn Asp Ile Pro 
    930                 935                 940                 


Ala Ile Gln Lys Tyr Ala Lys Lys Asn Asn Gly Pro Leu Ile Arg Ser 
945                 950                 955                 960 


Leu Lys Tyr Tyr Asp Gly Lys Leu Asn Lys His Ile Asn Ile Thr Lys 
                965                 970                 975     


Asp Ser Gln Gly Arg Pro Val Glu Lys Thr Lys Asn Gly Arg Lys Val 
            980                 985                 990         


Thr Leu Gln Ser Leu Lys Pro Tyr  Arg Tyr Asp Ile Tyr  Gln Asp Leu 
        995                 1000                 1005             


Glu Thr  Lys Ala Tyr Tyr Thr  Val Gln Leu Tyr Tyr  Ser Asp Leu 
    1010                 1015                 1020             


Arg Phe  Val Glu Gly Lys Tyr  Gly Ile Thr Glu Lys  Glu Tyr Met 
    1025                 1030                 1035             


Lys Lys  Val Ala Glu Gln Thr  Lys Gly Gln Val Val  Arg Phe Cys 
    1040                 1045                 1050             


Phe Ser  Leu Gln Lys Asn Asp  Gly Leu Glu Ile Glu  Trp Lys Asp 
    1055                 1060                 1065             


Ser Gln  Arg Tyr Asp Val Arg  Phe Tyr Asn Phe Gln  Ser Ala Asn 
    1070                 1075                 1080             


Ser Ile  Asn Phe Lys Gly Leu  Glu Gln Glu Met Met  Pro Ala Glu 
    1085                 1090                 1095             


Asn Gln  Phe Lys Gln Lys Pro  Tyr Asn Asn Gly Ala  Ile Asn Leu 
    1100                 1105                 1110             


Asn Ile  Ala Lys Tyr Gly Lys  Glu Gly Lys Lys Leu  Arg Lys Phe 
    1115                 1120                 1125             


Asn Thr  Asp Ile Leu Gly Lys  Lys His Tyr Leu Phe  Tyr Glu Lys 
    1130                 1135                 1140             


Glu Pro  Lys Asn Ile Ile Lys  
    1145                 1150 


<210> 196
<211> 1150
<212> PRT
<213> Enterococcus faecalis


<220>
<223> Enterococcus faecalis TX0012

<400> 196
Met Tyr Ser Ile Gly Leu Asp Leu Gly Ile Ser Ser Val Gly Trp Ser 
1               5                   10                  15      


Val Ile Asp Glu Arg Thr Gly Asn Val Ile Asp Leu Gly Val Arg Leu 
            20                  25                  30          


Phe Ser Ala Lys Asn Ser Glu Lys Asn Leu Glu Arg Arg Thr Asn Arg 
        35                  40                  45              


Gly Gly Arg Arg Leu Ile Arg Arg Lys Thr Asn Arg Leu Lys Asp Ala 
    50                  55                  60                  


Lys Lys Ile Leu Ala Ala Val Gly Phe Tyr Glu Asp Lys Ser Leu Lys 
65                  70                  75                  80  


Asn Ser Cys Pro Tyr Gln Leu Arg Val Lys Gly Leu Thr Glu Pro Leu 
                85                  90                  95      


Ser Arg Gly Glu Ile Tyr Lys Val Thr Leu His Ile Leu Lys Lys Arg 
            100                 105                 110         


Gly Ile Ser Tyr Leu Asp Glu Val Asp Thr Glu Ala Ala Lys Glu Ser 
        115                 120                 125             


Gln Asp Tyr Lys Glu Gln Val Arg Lys Asn Ala Gln Leu Leu Thr Lys 
    130                 135                 140                 


Tyr Thr Pro Gly Gln Ile Gln Leu Gln Arg Leu Lys Glu Asn Asn Arg 
145                 150                 155                 160 


Val Lys Thr Gly Ile Asn Ala Gln Gly Asn Tyr Gln Leu Asn Val Phe 
                165                 170                 175     


Lys Val Ser Ala Tyr Ala Asn Glu Leu Ala Thr Ile Leu Lys Thr Gln 
            180                 185                 190         


Gln Ala Phe Tyr Pro Asn Glu Leu Thr Asp Asp Trp Ile Ala Leu Phe 
        195                 200                 205             


Val Gln Pro Gly Ile Ala Glu Glu Ala Gly Leu Ile Tyr Arg Lys Arg 
    210                 215                 220                 


Pro Tyr Tyr His Gly Pro Gly Asn Glu Ala Asn Asn Ser Pro Tyr Gly 
225                 230                 235                 240 


Arg Trp Ser Asp Phe Gln Lys Thr Gly Glu Pro Ala Thr Asn Ile Phe 
                245                 250                 255     


Asp Lys Leu Ile Gly Lys Asp Phe Gln Gly Glu Leu Arg Ala Ser Gly 
            260                 265                 270         


Leu Ser Leu Ser Ala Gln Gln Tyr Asn Leu Leu Asn Asp Leu Thr Asn 
        275                 280                 285             


Leu Lys Ile Asp Gly Glu Val Pro Leu Ser Ser Glu Gln Lys Glu Tyr 
    290                 295                 300                 


Ile Leu Thr Glu Leu Met Thr Lys Glu Phe Thr Arg Phe Gly Val Asn 
305                 310                 315                 320 


Asp Val Val Lys Leu Leu Gly Val Lys Lys Glu Arg Leu Ser Gly Trp 
                325                 330                 335     


Arg Leu Asp Lys Lys Gly Lys Pro Glu Ile His Thr Leu Lys Gly Tyr 
            340                 345                 350         


Arg Asn Trp Arg Lys Ile Phe Ala Glu Ala Gly Ile Asp Leu Ala Thr 
        355                 360                 365             


Leu Pro Thr Glu Thr Ile Asp Cys Leu Ala Lys Val Leu Thr Leu Asn 
    370                 375                 380                 


Thr Glu Arg Glu Gly Ile Glu Asn Thr Leu Ala Phe Glu Leu Pro Glu 
385                 390                 395                 400 


Leu Ser Glu Ser Val Lys Leu Leu Val Leu Asp Arg Tyr Lys Glu Leu 
                405                 410                 415     


Ser Gln Ser Ile Ser Thr Gln Ser Trp His Arg Phe Ser Leu Lys Thr 
            420                 425                 430         


Leu His Leu Leu Ile Pro Glu Leu Met Asn Ala Thr Ser Glu Gln Asn 
        435                 440                 445             


Thr Leu Leu Glu Gln Phe Gln Leu Lys Ser Asp Val Arg Lys Arg Tyr 
    450                 455                 460                 


Ser Glu Tyr Lys Lys Leu Pro Thr Lys Asp Val Leu Ala Glu Ile Tyr 
465                 470                 475                 480 


Asn Pro Thr Val Asn Lys Thr Val Ser Gln Ala Phe Lys Val Ile Asp 
                485                 490                 495     


Ala Leu Leu Val Lys Tyr Gly Lys Glu Gln Ile Arg Tyr Ile Thr Ile 
            500                 505                 510         


Glu Met Pro Arg Asp Asp Asn Glu Glu Asp Glu Lys Lys Arg Ile Lys 
        515                 520                 525             


Glu Leu His Ala Lys Asn Ser Gln Arg Lys Asn Asp Ser Gln Ser Tyr 
    530                 535                 540                 


Phe Met Gln Lys Ser Gly Trp Ser Gln Glu Lys Phe Gln Thr Thr Ile 
545                 550                 555                 560 


Gln Lys Asn Arg Arg Phe Leu Ala Lys Leu Leu Tyr Tyr Tyr Glu Gln 
                565                 570                 575     


Asp Gly Ile Cys Ala Tyr Thr Gly Leu Pro Ile Ser Pro Glu Leu Leu 
            580                 585                 590         


Val Ser Asp Ser Thr Glu Ile Asp His Ile Ile Pro Ile Ser Ile Ser 
        595                 600                 605             


Leu Asp Asp Ser Ile Asn Asn Lys Val Leu Val Leu Ser Lys Ala Asn 
    610                 615                 620                 


Gln Val Lys Gly Gln Gln Thr Pro Tyr Asp Ala Trp Met Asp Gly Ser 
625                 630                 635                 640 


Phe Lys Lys Ile Asn Gly Lys Phe Ser Asn Trp Asp Asp Tyr Gln Lys 
                645                 650                 655     


Trp Val Glu Ser Arg His Phe Ser His Lys Lys Glu Asn Asn Leu Leu 
            660                 665                 670         


Glu Thr Arg Asn Ile Phe Asp Ser Glu Gln Val Glu Lys Phe Leu Ala 
        675                 680                 685             


Arg Asn Leu Asn Asp Thr Arg Tyr Ala Ser Arg Leu Val Leu Asn Thr 
    690                 695                 700                 


Leu Gln Ser Phe Phe Thr Asn Gln Glu Thr Lys Val Arg Val Val Asn 
705                 710                 715                 720 


Gly Ser Phe Thr His Thr Leu Arg Lys Lys Trp Gly Ala Asp Leu Asp 
                725                 730                 735     


Lys Thr Arg Glu Thr His His His His Ala Val Asp Ala Thr Leu Cys 
            740                 745                 750         


Ala Val Thr Ser Phe Val Lys Val Ser Arg Tyr His Tyr Ala Val Lys 
        755                 760                 765             


Glu Glu Thr Gly Glu Lys Val Met Arg Glu Ile Asp Phe Glu Thr Gly 
    770                 775                 780                 


Glu Ile Val Asn Glu Met Ser Tyr Trp Glu Phe Lys Lys Ser Lys Lys 
785                 790                 795                 800 


Tyr Glu Arg Lys Thr Tyr Gln Val Lys Trp Pro Asn Phe Arg Glu Gln 
                805                 810                 815     


Leu Lys Pro Val Asn Leu His Pro Arg Ile Lys Phe Ser His Gln Val 
            820                 825                 830         


Asp Arg Lys Ala Asn Arg Lys Leu Ser Asp Ala Thr Ile Tyr Ser Val 
        835                 840                 845             


Arg Glu Lys Thr Glu Val Lys Thr Leu Lys Ser Gly Lys Gln Lys Ile 
    850                 855                 860                 


Thr Thr Asp Glu Tyr Thr Ile Gly Lys Ile Lys Asp Ile Tyr Thr Leu 
865                 870                 875                 880 


Asp Gly Trp Glu Ala Phe Lys Lys Lys Gln Asp Lys Leu Leu Met Lys 
                885                 890                 895     


Asp Leu Asp Glu Lys Thr Tyr Glu Arg Leu Leu Ser Ile Ala Glu Thr 
            900                 905                 910         


Thr Pro Asp Phe Gln Glu Val Glu Glu Lys Asn Gly Lys Val Lys Arg 
        915                 920                 925             


Val Lys Arg Ser Pro Phe Ala Val Tyr Cys Glu Glu Asn Asp Ile Pro 
    930                 935                 940                 


Ala Ile Gln Lys Tyr Ala Lys Lys Asn Asn Gly Pro Leu Ile Arg Ser 
945                 950                 955                 960 


Leu Lys Tyr Tyr Asp Gly Lys Leu Asn Lys His Ile Asn Ile Thr Lys 
                965                 970                 975     


Asp Ser Gln Gly Arg Pro Val Glu Lys Thr Lys Asn Gly Arg Lys Val 
            980                 985                 990         


Thr Leu Gln Ser Leu Lys Pro Tyr  Arg Tyr Asp Ile Tyr  Gln Asp Leu 
        995                 1000                 1005             


Glu Thr  Lys Ala Tyr Tyr Thr  Val Gln Leu Tyr Tyr  Ser Asp Leu 
    1010                 1015                 1020             


Arg Phe  Val Glu Gly Lys Tyr  Gly Ile Thr Glu Lys  Glu Tyr Met 
    1025                 1030                 1035             


Lys Lys  Val Ala Glu Gln Thr  Lys Gly Gln Val Val  Arg Phe Cys 
    1040                 1045                 1050             


Phe Ser  Leu Gln Lys Asn Asp  Gly Leu Glu Ile Glu  Trp Lys Asp 
    1055                 1060                 1065             


Ser Gln  Arg Tyr Asp Val Arg  Phe Tyr Asn Phe Gln  Ser Ala Asn 
    1070                 1075                 1080             


Ser Ile  Asn Phe Lys Gly Leu  Glu Gln Glu Met Met  Pro Ala Glu 
    1085                 1090                 1095             


Asn Gln  Phe Lys Gln Lys Pro  Tyr Asn Asn Gly Ala  Ile Asn Leu 
    1100                 1105                 1110             


Asn Ile  Ala Lys Tyr Gly Lys  Glu Gly Lys Lys Leu  Arg Lys Phe 
    1115                 1120                 1125             


Asn Thr  Asp Ile Leu Gly Lys  Lys His Tyr Leu Phe  Tyr Glu Lys 
    1130                 1135                 1140             


Glu Pro  Lys Asn Ile Ile Lys  
    1145                 1150 


<210> 197
<211> 1337
<212> PRT
<213> Enterococcus faecalis


<220>
<223> Enterococcus faecalis TX0470

<400> 197
Met Lys Lys Asp Tyr Val Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Met Thr Glu Asp Tyr Gln Leu Val Lys Lys Lys Met 
            20                  25                  30          


Pro Ile Tyr Gly Asn Thr Glu Lys Lys Lys Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Glu Glu Gly His Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Ile Ser Arg Arg Arg Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Ala Phe Phe Glu Glu Ala Met Thr Ala Leu Asp Glu Asn 
                85                  90                  95      


Phe Phe Ala Arg Leu Gln Glu Ser Phe Leu Val Pro Glu Asp Lys Lys 
            100                 105                 110         


Trp His Arg His Pro Ile Phe Ala Lys Leu Glu Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Gln Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Val Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Ser Thr 
                165                 170                 175     


Glu Asn Ile Ser Val Lys Glu Gln Phe Gln Gln Phe Met Ile Ile Tyr 
            180                 185                 190         


Asn Gln Thr Phe Val Asn Gly Glu Ser Arg Leu Val Ser Thr Pro Leu 
        195                 200                 205             


Pro Glu Ser Val Leu Ile Glu Glu Glu Leu Thr Glu Lys Ala Ser Arg 
    210                 215                 220                 


Thr Lys Lys Ser Glu Lys Val Leu Gln Gln Phe Pro Gln Glu Lys Ala 
225                 230                 235                 240 


Asn Gly Leu Phe Gly Gln Phe Leu Lys Leu Met Val Gly Asn Lys Ala 
                245                 250                 255     


Asp Phe Lys Lys Val Phe Gly Leu Glu Glu Glu Ala Lys Ile Thr Tyr 
            260                 265                 270         


Ala Ser Glu Ser Tyr Glu Glu Asp Leu Glu Gly Ile Leu Ala Lys Val 
        275                 280                 285             


Gly Asp Glu Tyr Ser Asp Val Phe Leu Ala Ala Lys Asn Val Tyr Asp 
    290                 295                 300                 


Ala Val Glu Leu Ser Thr Ile Leu Ala Asp Ser Asp Lys Lys Ser His 
305                 310                 315                 320 


Ala Lys Leu Ser Ser Ser Met Ile Val Arg Phe Thr Glu His Gln Glu 
                325                 330                 335     


Asp Leu Lys Asn Phe Lys Arg Phe Ile Arg Glu Asn Cys Pro Asp Glu 
            340                 345                 350         


Tyr Asp Asn Leu Phe Lys Asn Glu Gln Lys Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Thr His Ala Gly Lys Val Ser Gln Leu Lys Phe Tyr Gln Tyr Val 
    370                 375                 380                 


Lys Lys Ile Ile Gln Asp Ile Ala Gly Ala Glu Tyr Phe Leu Glu Lys 
385                 390                 395                 400 


Ile Ala Gln Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
                405                 410                 415     


Val Ile Pro His Gln Ile His Leu Ala Glu Leu Gln Ala Ile Ile His 
            420                 425                 430         


Arg Gln Ala Ala Tyr Tyr Pro Phe Leu Lys Glu Asn Gln Glu Lys Ile 
        435                 440                 445             


Glu Gln Leu Val Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ser 
    450                 455                 460                 


Lys Gly Asp Ala Ser Thr Phe Ala Trp Leu Lys Arg Gln Ser Glu Glu 
465                 470                 475                 480 


Pro Ile Arg Pro Trp Asn Leu Gln Glu Thr Val Asp Leu Asp Gln Ser 
                485                 490                 495     


Ala Thr Ala Phe Ile Glu Arg Met Thr Asn Phe Asp Thr Tyr Leu Pro 
            500                 505                 510         


Ser Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys Phe Met 
        515                 520                 525             


Val Phe Asn Glu Leu Thr Lys Ile Ser Tyr Thr Asp Asp Arg Gly Ile 
    530                 535                 540                 


Lys Ala Asn Phe Ser Gly Lys Glu Lys Glu Lys Ile Phe Asp Tyr Leu 
545                 550                 555                 560 


Phe Lys Thr Arg Arg Lys Val Lys Lys Lys Asp Ile Ile Gln Phe Tyr 
                565                 570                 575     


Arg Asn Glu Tyr Asn Thr Glu Ile Val Thr Leu Ser Gly Leu Glu Glu 
            580                 585                 590         


Asp Gln Phe Asn Ala Ser Phe Ser Thr Tyr Gln Asp Leu Leu Lys Cys 
        595                 600                 605             


Gly Leu Thr Arg Ala Glu Leu Asp His Pro Asp Asn Ala Glu Lys Leu 
    610                 615                 620                 


Glu Asp Ile Ile Lys Ile Leu Thr Ile Phe Glu Asp Arg Gln Arg Ile 
625                 630                 635                 640 


Arg Thr Gln Leu Ser Thr Phe Lys Gly Gln Phe Ser Ala Glu Val Leu 
                645                 650                 655     


Lys Lys Leu Glu Arg Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 
            660                 665                 670         


Lys Leu Ile Asn Gly Ile Tyr Asp Lys Glu Ser Gly Lys Thr Ile Leu 
        675                 680                 685             


Asp Tyr Leu Val Lys Asp Asp Gly Val Ser Lys His Tyr Asn Arg Asn 
    690                 695                 700                 


Phe Met Gln Leu Ile Asn Asp Ser Gln Leu Ser Phe Lys Asn Ala Ile 
705                 710                 715                 720 


Gln Lys Ala Gln Ser Ser Glu His Glu Glu Thr Leu Ser Glu Thr Val 
                725                 730                 735     


Asn Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Tyr Gln Ser 
            740                 745                 750         


Leu Lys Ile Val Asp Glu Leu Val Ala Ile Met Gly Tyr Ala Pro Lys 
        755                 760                 765             


Arg Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Ser Thr Gly 
    770                 775                 780                 


Lys Arg Arg Ser Ile Gln Arg Leu Lys Ile Val Glu Lys Ala Met Ala 
785                 790                 795                 800 


Glu Ile Gly Ser Asn Leu Leu Lys Glu Gln Pro Thr Thr Asn Glu Gln 
                805                 810                 815     


Leu Arg Asp Thr Arg Leu Phe Leu Tyr Tyr Met Gln Asn Gly Lys Asp 
            820                 825                 830         


Met Tyr Thr Gly Asp Glu Leu Ser Leu His Arg Leu Ser His Tyr Asp 
        835                 840                 845             


Ile Asp His Ile Ile Pro Gln Ser Phe Met Lys Asp Asp Ser Leu Asp 
    850                 855                 860                 


Asn Leu Val Leu Val Gly Ser Thr Glu Asn Arg Gly Lys Ser Asp Asp 
865                 870                 875                 880 


Val Pro Ser Lys Glu Val Val Lys Asp Met Lys Ala Tyr Trp Glu Lys 
                885                 890                 895     


Leu Tyr Ala Ala Gly Leu Ile Ser Gln Arg Lys Phe Gln Arg Leu Thr 
            900                 905                 910         


Lys Gly Glu Gln Gly Gly Leu Thr Leu Glu Asp Lys Ala His Phe Ile 
        915                 920                 925             


Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys Asn Val Ala Gly 
    930                 935                 940                 


Ile Leu Asp Gln Arg Tyr Asn Ala Lys Ser Lys Glu Lys Lys Val Gln 
945                 950                 955                 960 


Ile Ile Thr Leu Lys Ala Ser Leu Thr Ser Gln Phe Arg Ser Ile Phe 
                965                 970                 975     


Gly Leu Tyr Lys Val Arg Glu Val Asn Asp Tyr His His Gly Gln Asp 
            980                 985                 990         


Ala Tyr Leu Asn Cys Val Val Ala  Thr Thr Leu Leu Lys  Val Tyr Pro 
        995                 1000                 1005             


Asn Leu  Ala Pro Glu Phe Val  Tyr Gly Glu Tyr Pro  Lys Phe Gln 
    1010                 1015                 1020             


Thr Phe  Lys Glu Asn Lys Ala  Thr Ala Lys Ala Ile  Ile Tyr Thr 
    1025                 1030                 1035             


Asn Leu  Leu Arg Phe Phe Thr  Glu Asp Glu Pro Arg  Phe Thr Lys 
    1040                 1045                 1050             


Asp Gly  Glu Ile Leu Trp Ser  Asn Ser Tyr Leu Lys  Thr Ile Lys 
    1055                 1060                 1065             


Lys Glu  Leu Asn Tyr His Gln  Met Asn Ile Val Lys  Lys Val Glu 
    1070                 1075                 1080             


Val Gln  Lys Gly Gly Phe Ser  Lys Glu Ser Ile Lys  Pro Lys Gly 
    1085                 1090                 1095             


Pro Ser  Asn Lys Leu Ile Pro  Val Lys Asn Gly Leu  Asp Pro Gln 
    1100                 1105                 1110             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Ile Val Ala Tyr  Thr Val Leu 
    1115                 1120                 1125             


Phe Thr  His Glu Lys Gly Lys  Lys Pro Leu Ile Lys  Gln Glu Ile 
    1130                 1135                 1140             


Leu Gly  Ile Thr Ile Met Glu  Lys Thr Arg Phe Glu  Gln Asn Pro 
    1145                 1150                 1155             


Ile Leu  Phe Leu Glu Glu Lys  Gly Phe Leu Arg Pro  Arg Val Leu 
    1160                 1165                 1170             


Met Lys  Leu Pro Lys Tyr Thr  Leu Tyr Glu Phe Pro  Glu Gly Arg 
    1175                 1180                 1185             


Arg Arg  Leu Leu Ala Ser Ala  Lys Glu Ala Gln Lys  Gly Asn Gln 
    1190                 1195                 1200             


Met Val  Leu Pro Glu His Leu  Leu Thr Leu Leu Tyr  His Ala Lys 
    1205                 1210                 1215             


Gln Cys  Leu Leu Pro Asn Gln  Ser Glu Ser Leu Ala  Tyr Val Glu 
    1220                 1225                 1230             


Gln His  Gln Pro Glu Phe Gln  Glu Ile Leu Glu Arg  Val Val Asp 
    1235                 1240                 1245             


Phe Ala  Glu Val His Thr Leu  Ala Lys Ser Lys Val  Gln Gln Ile 
    1250                 1255                 1260             


Val Lys  Leu Phe Glu Ala Asn  Gln Thr Ala Asp Val  Lys Glu Ile 
    1265                 1270                 1275             


Ala Ala  Ser Phe Ile Gln Leu  Met Gln Phe Asn Ala  Met Gly Ala 
    1280                 1285                 1290             


Pro Ser  Thr Phe Lys Phe Phe  Gln Lys Asp Ile Glu  Arg Ala Arg 
    1295                 1300                 1305             


Tyr Thr  Ser Ile Lys Glu Ile  Phe Asp Ala Thr Ile  Ile Tyr Gln 
    1310                 1315                 1320             


Ser Thr  Thr Gly Leu Tyr Glu  Thr Arg Arg Lys Val  Val Asp 
    1325                 1330                 1335         


<210> 198
<211> 1150
<212> PRT
<213> Enterococcus faecalis


<220>
<223> Enterococcus faecalis TX1342

<400> 198
Met Tyr Ser Ile Gly Leu Asp Leu Gly Val Ser Ser Val Gly Trp Ser 
1               5                   10                  15      


Val Ile Asp Glu Arg Thr Gly Asn Val Ile Asp Leu Gly Val Arg Leu 
            20                  25                  30          


Phe Ser Ala Lys Asn Ser Glu Lys Asn Leu Glu Arg Arg Thr Asn Arg 
        35                  40                  45              


Gly Gly Arg Arg Leu Ile Arg Arg Lys Thr Asn Arg Leu Lys Asp Ala 
    50                  55                  60                  


Lys Lys Ile Leu Ala Ala Val Gly Phe Tyr Glu Asp Lys Ser Leu Lys 
65                  70                  75                  80  


Asn Ser Cys Pro Tyr Gln Leu Arg Val Lys Gly Leu Thr Glu Pro Leu 
                85                  90                  95      


Ser Lys Gly Glu Ile Tyr Lys Val Thr Leu His Ile Leu Lys Lys Arg 
            100                 105                 110         


Gly Ile Ser Tyr Leu Asp Glu Asp Asp Thr Glu Ala Ala Lys Glu Ser 
        115                 120                 125             


Gln Asp Tyr Lys Glu Gln Val Arg Glu Asn Ala Gln Leu Leu Thr Lys 
    130                 135                 140                 


Tyr Thr Pro Gly Gln Ile Gln Leu Gln Arg Leu Lys Glu Asn Asn Arg 
145                 150                 155                 160 


Val Lys Thr Gly Ile Asn Ala Gln Gly Asn Tyr Gln Leu Asn Val Phe 
                165                 170                 175     


Lys Val Ser Ala Tyr Ala Asn Glu Leu Ala Thr Ile Leu Lys Thr Gln 
            180                 185                 190         


Gln Ala Phe Tyr Pro Asn Glu Leu Thr Asp Asp Trp Ile Ala Leu Phe 
        195                 200                 205             


Val Gln Pro Gly Ile Ala Glu Glu Ala Gly Leu Ile Tyr Arg Lys Arg 
    210                 215                 220                 


Pro Tyr Tyr His Gly Pro Gly Asn Glu Ala Asn Asn Ser Pro Tyr Gly 
225                 230                 235                 240 


Arg Trp Ser Asp Phe Lys Lys Thr Gly Gln Pro Ala Thr Asn Ile Phe 
                245                 250                 255     


Asp Lys Leu Ile Gly Lys Asp Phe Gln Gly Glu Leu Arg Ala Ser Gly 
            260                 265                 270         


Leu Ser Leu Ser Ala Gln Gln Tyr Asn Leu Leu Asn Asp Leu Thr Asn 
        275                 280                 285             


Leu Lys Ile Asp Gly Glu Ile Pro Leu Ser Pro Glu Gln Lys Glu Tyr 
    290                 295                 300                 


Ile Leu Ala Glu Leu Met Thr Lys Glu Phe Thr Arg Phe Gly Ile Asn 
305                 310                 315                 320 


Asp Val Ala Lys Leu Leu Gly Val Lys Lys Glu Arg Leu Ser Gly Trp 
                325                 330                 335     


Arg Leu Asp Lys Lys Gly Lys Pro Glu Ile His Thr Leu Lys Gly Tyr 
            340                 345                 350         


Arg Asn Trp Arg Lys Ile Phe Ala Glu Ser Gly Ile Asp Leu Ala Thr 
        355                 360                 365             


Leu Pro Thr Glu Thr Ile Asp Cys Leu Ala Lys Val Leu Thr Leu Asn 
    370                 375                 380                 


Thr Glu Arg Glu Gly Ile Glu Asn Thr Leu Ala Phe Glu Leu Pro Glu 
385                 390                 395                 400 


Leu Ala Glu Ser Val Lys Leu Leu Val Leu Asp Arg Tyr Lys Glu Leu 
                405                 410                 415     


Ser Gln Ser Val Ser Thr Gln Ala Trp His Arg Phe Ser Leu Lys Thr 
            420                 425                 430         


Leu His Leu Leu Ile Pro Glu Leu Met Asn Ala Thr Ser Glu Gln Asn 
        435                 440                 445             


Thr Leu Leu Glu Gln Phe Gln Leu Lys Ser Asp Val Arg Lys Arg Tyr 
    450                 455                 460                 


Ser Glu Tyr Lys Lys Leu Pro Thr Lys Asp Val Leu Thr Glu Ile Tyr 
465                 470                 475                 480 


Asn Pro Thr Val Asn Lys Thr Val Ser Gln Ala Phe Lys Val Ile Asp 
                485                 490                 495     


Ala Leu Leu Val Lys Tyr Gly Lys Glu Gln Ile Arg Tyr Ile Thr Ile 
            500                 505                 510         


Glu Met Pro Arg Asp Asp Asn Glu Glu Asp Glu Lys Lys Arg Ile Lys 
        515                 520                 525             


Glu Leu His Ala Lys Asn Ser Gln Arg Lys Asn Asp Ser Gln Ser Tyr 
    530                 535                 540                 


Phe Met Gln Lys Ser Gly Trp Ser Gln Glu Lys Phe Gln Thr Thr Ile 
545                 550                 555                 560 


Gln Lys Asn Arg Arg Phe Leu Ala Lys Leu Leu Tyr Tyr Tyr Glu Gln 
                565                 570                 575     


Asp Gly Ile Cys Ala Tyr Thr Gly Leu Ser Ile Ser Pro Glu Leu Leu 
            580                 585                 590         


Val Ser Asp Ser Thr Glu Ile Asp His Ile Ile Pro Ile Ser Ile Ser 
        595                 600                 605             


Leu Asp Asp Ser Ile Asn Asn Lys Val Leu Val Leu Ser Lys Ala Asn 
    610                 615                 620                 


Gln Val Lys Gly Gln Gln Thr Pro Tyr Asp Ala Trp Met Asp Gly Ser 
625                 630                 635                 640 


Phe Lys Lys Ile Asn Gly Lys Phe Ser Asn Trp Asp Asp Tyr Gln Lys 
                645                 650                 655     


Trp Val Glu Ser Arg His Phe Ser His Lys Lys Glu Asn Asn Leu Leu 
            660                 665                 670         


Glu Thr Arg Asn Ile Phe Asp Ser Glu Gln Val Glu Lys Phe Leu Ala 
        675                 680                 685             


Arg Asn Leu Asn Asp Thr Arg Tyr Ala Ser Arg Leu Val Leu Asn Thr 
    690                 695                 700                 


Leu Gln Ser Phe Phe Ala Asn Gln Glu Thr Lys Val Arg Val Val Asn 
705                 710                 715                 720 


Gly Ser Phe Thr His Thr Leu Arg Lys Lys Trp Gly Ala Asp Leu Asp 
                725                 730                 735     


Lys Thr Arg Glu Thr His His His His Ala Val Asp Ala Thr Leu Cys 
            740                 745                 750         


Ala Val Thr Pro Phe Val Lys Val Ser Arg Tyr His Tyr Ala Val Lys 
        755                 760                 765             


Glu Glu Thr Gly Glu Lys Val Met Arg Glu Ile Asp Phe Glu Thr Gly 
    770                 775                 780                 


Glu Ile Val Asp Glu Met Ser Tyr Arg Glu Phe Lys Lys Ser Lys Lys 
785                 790                 795                 800 


Tyr Glu Arg Lys Thr Tyr Gln Val Lys Trp Pro Asn Phe Arg Glu Gln 
                805                 810                 815     


Leu Lys Pro Val Asn Leu His Pro Arg Ile Lys Phe Ser His Gln Val 
            820                 825                 830         


Asp Arg Lys Ala Asn Arg Lys Leu Ser Asp Ala Thr Ile Tyr Ser Val 
        835                 840                 845             


Arg Glu Lys Thr Glu Val Lys Thr Leu Lys Ser Gly Lys Gln Lys Ile 
    850                 855                 860                 


Thr Thr Asp Glu Tyr Thr Ile Gly Lys Ile Lys Asp Ile Tyr Thr Val 
865                 870                 875                 880 


Asp Gly Trp Glu Ala Phe Lys Lys Lys Gln Asp Lys Leu Leu Met Lys 
                885                 890                 895     


Asp Leu Asp Glu Lys Thr Tyr Glu Arg Leu Leu Ser Ile Ala Glu Thr 
            900                 905                 910         


Thr Pro Asp Phe Gln Glu Val Glu Glu Lys Asn Gly Lys Val Lys Arg 
        915                 920                 925             


Val Lys Arg Ser Pro Phe Ala Val Tyr Cys Glu Glu Asn Asp Ile Pro 
    930                 935                 940                 


Ala Ile Arg Lys Tyr Ala Lys Asn Asn Asn Gly Pro Leu Ile Arg Ser 
945                 950                 955                 960 


Leu Lys Tyr Tyr Asp Gly Lys Leu Asn Lys His Ile Asn Ile Thr Lys 
                965                 970                 975     


Asp Ser Gln Gly Arg Pro Val Glu Lys Thr Lys Asn Gly Arg Lys Val 
            980                 985                 990         


Thr Leu Gln Ser Leu Lys Pro Tyr  Arg Tyr Asp Ile Tyr  Gln Asp Leu 
        995                 1000                 1005             


Glu Thr  Lys Ala Tyr Tyr Thr  Val Gln Leu Tyr Tyr  Ser Asp Leu 
    1010                 1015                 1020             


Arg Phe  Val Glu Gly Lys Tyr  Gly Ile Thr Glu Lys  Glu Tyr Met 
    1025                 1030                 1035             


Lys Lys  Val Ala Glu Gln Thr  Lys Gly Gln Val Val  Arg Phe Cys 
    1040                 1045                 1050             


Phe Ser  Leu Gln Lys Asn Asp  Gly Leu Glu Ile Glu  Trp Lys Asp 
    1055                 1060                 1065             


Ser Gln  Cys Tyr Asp Val Arg  Phe Tyr Asn Phe Gln  Ser Ala Asn 
    1070                 1075                 1080             


Ser Ile  Asn Phe Lys Gly Leu  Glu Gln Glu Met Met  Pro Ala Glu 
    1085                 1090                 1095             


Asn Gln  Phe Lys Gln Lys Pro  Tyr Asn Asn Gly Ala  Ile Asn Leu 
    1100                 1105                 1110             


Asn Ile  Ala Lys Tyr Gly Lys  Glu Gly Lys Lys Leu  Arg Lys Phe 
    1115                 1120                 1125             


Asn Thr  Asp Ile Leu Gly Lys  Lys His Tyr Leu Tyr  Tyr Glu Lys 
    1130                 1135                 1140             


Glu Pro  Lys Asn Ile Ile Lys  
    1145                 1150 


<210> 199
<211> 1337
<212> PRT
<213> Enterococcus faecalis


<220>
<223> Enterococcus faecalis TX4244

<400> 199
Met Lys Lys Asp Tyr Val Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Met Thr Glu Asp Tyr Gln Leu Val Lys Lys Lys Met 
            20                  25                  30          


Pro Ile Tyr Gly Asn Thr Glu Lys Lys Lys Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Glu Glu Gly His Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Ile Ser Arg Arg Arg Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Ala Phe Phe Glu Glu Ala Met Thr Asp Leu Asp Glu Asn 
                85                  90                  95      


Phe Phe Ala Arg Leu Gln Glu Ser Phe Leu Val Pro Glu Asp Lys Lys 
            100                 105                 110         


Trp His Arg His Pro Ile Phe Ala Lys Leu Glu Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Gln Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Val Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Ser Thr 
                165                 170                 175     


Glu Asn Ile Ser Val Lys Glu Gln Phe Gln Gln Phe Met Ile Ile Tyr 
            180                 185                 190         


Asn Gln Thr Phe Val Asn Gly Glu Ser Arg Leu Val Ser Ala Pro Leu 
        195                 200                 205             


Pro Glu Ser Val Leu Ile Glu Glu Glu Leu Thr Glu Lys Ala Ser Arg 
    210                 215                 220                 


Thr Lys Lys Ser Glu Lys Val Leu Gln Gln Phe Pro Gln Glu Lys Ala 
225                 230                 235                 240 


Asn Gly Leu Phe Gly Gln Phe Leu Lys Leu Met Val Gly Asn Lys Ala 
                245                 250                 255     


Asp Phe Lys Lys Val Phe Gly Leu Glu Glu Glu Ala Lys Ile Thr Tyr 
            260                 265                 270         


Ala Ser Glu Ser Tyr Glu Glu Asp Leu Glu Gly Ile Leu Ala Lys Val 
        275                 280                 285             


Gly Asp Glu Tyr Ser Asp Val Phe Leu Ala Ala Lys Asn Val Tyr Asp 
    290                 295                 300                 


Ala Val Glu Leu Ser Thr Ile Leu Ala Asp Ser Asp Lys Lys Ser His 
305                 310                 315                 320 


Ala Lys Leu Ser Ser Ser Met Ile Val Arg Phe Thr Glu His Gln Glu 
                325                 330                 335     


Asp Leu Lys Lys Phe Lys Arg Phe Ile Arg Glu Asn Cys Pro Asp Glu 
            340                 345                 350         


Tyr Asp Asn Leu Phe Lys Asn Glu Gln Lys Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Ala His Ala Gly Lys Val Ser Gln Leu Lys Phe Tyr Gln Tyr Val 
    370                 375                 380                 


Lys Lys Ile Ile Gln Asp Ile Ala Gly Ala Glu Tyr Phe Leu Glu Lys 
385                 390                 395                 400 


Ile Ala Gln Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
                405                 410                 415     


Val Ile Pro His Gln Ile His Leu Ala Glu Leu Gln Ala Ile Ile His 
            420                 425                 430         


Arg Gln Ala Ala Tyr Tyr Pro Phe Leu Lys Glu Asn Gln Glu Lys Ile 
        435                 440                 445             


Glu Gln Leu Val Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ser 
    450                 455                 460                 


Lys Gly Asp Ala Ser Thr Phe Ala Trp Leu Lys Arg Gln Ser Glu Glu 
465                 470                 475                 480 


Pro Ile Arg Pro Trp Asn Leu Gln Glu Thr Val Asp Leu Asp Gln Ser 
                485                 490                 495     


Ala Thr Ala Phe Ile Glu Arg Met Thr Asn Phe Asp Thr Tyr Leu Pro 
            500                 505                 510         


Ser Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys Phe Met 
        515                 520                 525             


Val Phe Asn Glu Leu Thr Lys Ile Ser Tyr Thr Asp Asp Arg Gly Ile 
    530                 535                 540                 


Lys Ala Asn Phe Ser Gly Lys Glu Lys Glu Lys Ile Phe Asp Tyr Leu 
545                 550                 555                 560 


Phe Lys Thr Arg Arg Lys Val Lys Lys Lys Asp Ile Ile Gln Phe Tyr 
                565                 570                 575     


Arg Asn Glu Tyr Asn Thr Glu Ile Val Thr Leu Ser Gly Leu Glu Glu 
            580                 585                 590         


Asp Gln Phe Asn Ala Ser Phe Ser Thr Tyr Gln Asp Leu Leu Lys Cys 
        595                 600                 605             


Gly Leu Thr Arg Ala Glu Leu Asp His Pro Asp Asn Ala Glu Lys Leu 
    610                 615                 620                 


Glu Asp Ile Ile Lys Ile Leu Thr Ile Phe Glu Asp Arg Gln Arg Ile 
625                 630                 635                 640 


Arg Thr Gln Leu Ser Thr Phe Lys Gly Gln Phe Ser Ala Glu Val Leu 
                645                 650                 655     


Lys Lys Leu Glu Arg Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 
            660                 665                 670         


Lys Leu Ile Asn Gly Ile Tyr Asp Lys Glu Ser Gly Lys Thr Ile Leu 
        675                 680                 685             


Gly Tyr Leu Ile Lys Asp Asp Gly Val Ser Lys His Tyr Asn Arg Asn 
    690                 695                 700                 


Phe Met Gln Leu Ile Asn Asp Ser Gln Leu Ser Phe Lys Asn Ala Ile 
705                 710                 715                 720 


Gln Lys Ala Gln Ser Ser Glu His Glu Glu Thr Leu Ser Glu Thr Val 
                725                 730                 735     


Asn Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Tyr Gln Ser 
            740                 745                 750         


Leu Lys Ile Val Asp Glu Leu Val Ala Ile Met Gly Tyr Ala Pro Lys 
        755                 760                 765             


Arg Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Ser Thr Gly 
    770                 775                 780                 


Lys Arg Arg Ser Ile Gln Arg Leu Lys Ile Val Glu Lys Ala Met Ala 
785                 790                 795                 800 


Glu Ile Gly Ser Asn Leu Leu Lys Glu Gln Pro Thr Thr Asn Glu Gln 
                805                 810                 815     


Leu Arg Asp Thr Arg Leu Phe Leu Tyr Tyr Met Gln Asn Gly Lys Asp 
            820                 825                 830         


Met Tyr Thr Gly Asp Glu Leu Ser Leu His Arg Leu Ser His Tyr Asp 
        835                 840                 845             


Ile Asp His Ile Ile Pro Gln Ser Phe Met Lys Asp Asp Ser Leu Asp 
    850                 855                 860                 


Asn Leu Val Leu Val Gly Ser Thr Glu Asn Leu Gly Lys Ser Asp Asp 
865                 870                 875                 880 


Val Pro Ser Lys Glu Val Val Lys Asp Met Lys Ala Tyr Trp Glu Lys 
                885                 890                 895     


Leu Tyr Ala Ala Gly Leu Ile Ser Gln Arg Lys Phe Gln Arg Leu Thr 
            900                 905                 910         


Lys Gly Glu Gln Gly Gly Leu Thr Leu Glu Asp Lys Ala His Phe Ile 
        915                 920                 925             


Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys Asn Val Ala Gly 
    930                 935                 940                 


Ile Leu Asp Gln Arg Tyr Asn Ala Asn Ser Lys Glu Lys Lys Val Gln 
945                 950                 955                 960 


Ile Ile Thr Leu Lys Ala Ser Leu Thr Ser Gln Phe Arg Ser Ile Phe 
                965                 970                 975     


Gly Leu Tyr Lys Val Arg Glu Val Asn Asp Tyr His His Gly Gln Asp 
            980                 985                 990         


Ala Tyr Leu Asn Cys Val Val Ala  Thr Thr Leu Leu Lys  Val Tyr Pro 
        995                 1000                 1005             


Asn Leu  Ala Pro Glu Phe Val  Tyr Gly Glu Tyr Pro  Lys Phe Gln 
    1010                 1015                 1020             


Thr Phe  Lys Glu Asn Lys Ala  Thr Ala Lys Ala Ile  Ile Tyr Thr 
    1025                 1030                 1035             


Asn Leu  Leu Arg Phe Phe Thr  Glu Asp Glu Pro Arg  Phe Thr Lys 
    1040                 1045                 1050             


Asp Gly  Glu Ile Leu Trp Ser  Asn Ser Tyr Leu Lys  Thr Ile Lys 
    1055                 1060                 1065             


Lys Glu  Leu Asn Tyr His Gln  Met Asn Ile Val Lys  Lys Val Glu 
    1070                 1075                 1080             


Val Gln  Lys Gly Gly Phe Ser  Lys Glu Ser Ile Lys  Pro Lys Gly 
    1085                 1090                 1095             


Pro Ser  Asn Lys Leu Ile Pro  Val Lys Asn Gly Leu  Asp Pro Gln 
    1100                 1105                 1110             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Ile Val Ala Tyr  Thr Val Leu 
    1115                 1120                 1125             


Phe Thr  His Glu Lys Gly Lys  Lys Pro Leu Ile Lys  Gln Glu Ile 
    1130                 1135                 1140             


Leu Gly  Ile Thr Ile Met Glu  Lys Thr Arg Phe Glu  Gln Asn Pro 
    1145                 1150                 1155             


Ile Leu  Phe Leu Glu Glu Lys  Gly Phe Leu Arg Pro  Arg Val Leu 
    1160                 1165                 1170             


Met Lys  Leu Pro Lys Tyr Thr  Leu Tyr Glu Phe Pro  Glu Gly Arg 
    1175                 1180                 1185             


Arg Arg  Leu Leu Ala Ser Ala  Lys Glu Ala Gln Lys  Gly Asn Gln 
    1190                 1195                 1200             


Met Val  Leu Pro Glu His Leu  Leu Thr Leu Leu Tyr  His Ala Lys 
    1205                 1210                 1215             


Gln Cys  Leu Leu Pro Asn Gln  Ser Glu Ser Leu Ala  Tyr Val Glu 
    1220                 1225                 1230             


Gln His  Gln Pro Glu Phe Gln  Glu Ile Leu Glu Arg  Val Val Asp 
    1235                 1240                 1245             


Phe Ala  Glu Val His Thr Leu  Ala Lys Ser Lys Val  Gln Gln Ile 
    1250                 1255                 1260             


Val Lys  Leu Phe Glu Ala Asn  Gln Thr Ala Asp Val  Lys Glu Ile 
    1265                 1270                 1275             


Ala Ala  Ser Phe Ile Gln Leu  Met Gln Phe Asn Ala  Met Gly Ala 
    1280                 1285                 1290             


Pro Ser  Thr Phe Lys Phe Phe  Gln Lys Asp Ile Glu  Arg Ala Arg 
    1295                 1300                 1305             


Tyr Thr  Ser Ile Lys Glu Ile  Phe Asp Ala Thr Ile  Ile Tyr Gln 
    1310                 1315                 1320             


Ser Thr  Thr Gly Leu Tyr Glu  Thr Arg Arg Lys Val  Val Asp 
    1325                 1330                 1335         


<210> 200
<211> 1339
<212> PRT
<213> Enterococcus faecium


<220>
<223> Enterococcus faecium 1,141,733

<400> 200
Met Lys Lys Glu Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Val Leu Thr Asp Asp Tyr Arg Leu Val Ser Lys Lys Met 
            20                  25                  30          


Lys Val Ala Gly Asn Thr Glu Lys Ser Ser Thr Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Glu Gly Gln Thr Ala Glu Ala Arg Arg Ser 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Leu Ala Arg Arg Arg Gln Arg Ile Leu 
65                  70                  75                  80  


Glu Leu Gln Lys Ile Phe Ala Pro Glu Ile Leu Lys Ile Asp Glu His 
                85                  90                  95      


Phe Phe Ala Arg Leu Asn Glu Ser Phe Leu Val Leu Asp Glu Lys Lys 
            100                 105                 110         


Gln Ser Arg His Pro Val Phe Ala Thr Ile Lys Gln Glu Lys Ser Tyr 
        115                 120                 125             


His Gln Thr Tyr Pro Thr Ile Tyr His Leu Arg Gln Ala Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Ile Arg Leu Val Tyr Leu Ala Met Ala His 
145                 150                 155                 160 


Leu Leu Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Thr 
                165                 170                 175     


Glu Asn Ser Ser Val Thr Glu Thr Phe Arg Gln Phe Leu Ser Thr Tyr 
            180                 185                 190         


Asn Gln Gln Phe Ser Glu Ala Asp Asp Lys Gln Thr Glu Lys Leu Asp 
        195                 200                 205             


Glu Ala Val Asp Cys Ser Phe Val Phe Thr Glu Lys Met Ser Lys Thr 
    210                 215                 220                 


Lys Lys Ala Glu Thr Leu Leu Lys Tyr Phe Pro His Glu Lys Ser Asn 
225                 230                 235                 240 


Gly Tyr Leu Ser Gln Phe Ile Lys Leu Met Val Gly Asn Gln Gly Asn 
                245                 250                 255     


Phe Lys Asn Val Phe Gly Leu Glu Glu Ala Lys Leu Gln Phe Ser Lys 
            260                 265                 270         


Glu Thr Tyr Glu Glu Asp Leu Glu Glu Leu Leu Glu Lys Ile Gly Asp 
        275                 280                 285             


Asp Tyr Ile Asp Leu Phe Val Gln Ala Lys Asn Val Tyr Asp Ala Val 
    290                 295                 300                 


Leu Leu Ser Glu Ile Leu Ser Asp Ser Thr Lys Asn Thr Arg Ala Lys 
305                 310                 315                 320 


Leu Ser Ala Gly Met Ile Arg Arg Tyr Asp Ala His Lys Glu Asp Leu 
                325                 330                 335     


Val Leu Leu Lys Arg Phe Val Lys Glu Asn Leu Pro Lys Lys Tyr Arg 
            340                 345                 350         


Ala Phe Phe Gly Asp Asn Ser Val Asn Gly Tyr Ala Gly Tyr Ile Glu 
        355                 360                 365             


Gly His Ala Thr Gln Glu Asp Phe Tyr Lys Phe Val Lys Lys Glu Leu 
    370                 375                 380                 


Thr Gly Ile Arg Gly Ser Glu Val Phe Leu Thr Lys Ile Glu Gln Glu 
385                 390                 395                 400 


Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Val Ile Pro His 
                405                 410                 415     


Gln Ile His Leu Thr Glu Leu Arg Ala Ile Ile Ala Asn Gln Lys Lys 
            420                 425                 430         


His Tyr Pro Phe Leu Lys Glu Glu Gln Glu Lys Leu Glu Ser Leu Leu 
        435                 440                 445             


Thr Phe Lys Ile Pro Tyr Tyr Val Gly Pro Leu Ala Lys Lys Gln Glu 
    450                 455                 460                 


Asn Ser Pro Phe Ala Trp Leu Ile Arg Lys Ser Glu Glu Lys Ile Lys 
465                 470                 475                 480 


Pro Trp Asn Leu Pro Glu Ile Val Asp Met Glu Gly Ser Ala Val Arg 
                485                 490                 495     


Phe Ile Glu Arg Met Ile Asn Thr Asp Met Tyr Met Pro His Asn Lys 
            500                 505                 510         


Val Leu Pro Lys Asn Ser Leu Leu Tyr Gln Lys Phe Ser Ile Tyr Asn 
        515                 520                 525             


Glu Leu Thr Lys Val Arg Tyr Gln Asp Glu Arg Gly Gln Met Asn Tyr 
    530                 535                 540                 


Phe Ser Ser Ile Glu Lys Lys Glu Ile Phe His Glu Leu Phe Glu Lys 
545                 550                 555                 560 


Asn Arg Lys Val Thr Lys Lys Asp Leu Gln Glu Phe Leu Tyr Leu Lys 
                565                 570                 575     


Tyr Asp Ile Lys His Ala Glu Leu Ser Gly Ile Glu Lys Ala Phe Asn 
            580                 585                 590         


Ala Ser Tyr Thr Thr Tyr His Asp Phe Leu Thr Met Ser Glu Asn Lys 
        595                 600                 605             


Arg Glu Met Lys Gln Trp Leu Glu Asp Pro Glu Leu Ala Ser Met Phe 
    610                 615                 620                 


Glu Glu Ile Ile Lys Thr Leu Thr Val Phe Glu Asp Arg Glu Met Ile 
625                 630                 635                 640 


Lys Thr Arg Leu Ser His His Glu Ala Thr Leu Gly Lys His Ile Ile 
                645                 650                 655     


Lys Lys Leu Thr Lys Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 
            660                 665                 670         


Glu Leu Ile Gln Gly Ile Arg Asp Lys Gln Ser Asn Lys Thr Ile Leu 
        675                 680                 685             


Asp Tyr Leu Ile Asn Asp Asp Asp Phe Pro His His Arg Asn Arg Asn 
    690                 695                 700                 


Phe Met Gln Leu Ile Asn Asp Asp Ser Leu Ser Phe Lys Lys Glu Ile 
705                 710                 715                 720 


Lys Lys Ala Gln Met Ile Thr Asp Thr Glu Asn Leu Glu Glu Ile Val 
                725                 730                 735     


Lys Glu Leu Thr Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Ser 
            740                 745                 750         


Leu Lys Ile Val Asp Glu Ile Val Gly Ile Met Gly Tyr Glu Pro Ala 
        755                 760                 765             


Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Gly Arg Gly 
    770                 775                 780                 


Leu Lys Ser Ser Arg Pro Arg Leu Lys Ala Leu Glu Glu Ser Leu Lys 
785                 790                 795                 800 


Asp Phe Gly Ser Gln Leu Leu Lys Glu Tyr Pro Thr Asp Asn Ser Ser 
                805                 810                 815     


Leu Gln Lys Asp Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp 
            820                 825                 830         


Met Tyr Thr Gly Ala Pro Leu Asp Ile His Arg Leu Ser Asp Tyr Asp 
        835                 840                 845             


Ile Asp His Ile Ile Pro Arg Ser Phe Thr Thr Asp Asn Ser Ile Asp 
    850                 855                 860                 


Asn Lys Val Leu Val Ser Ser Lys Glu Asn Arg Leu Lys Lys Asp Asp 
865                 870                 875                 880 


Val Pro Ser Glu Lys Val Val Lys Lys Met Arg Ser Phe Trp Tyr Asp 
                885                 890                 895     


Leu Tyr Ser Ser Lys Leu Ile Ser Lys Arg Lys Leu Asp Asn Leu Thr 
            900                 905                 910         


Lys Ile Lys Leu Thr Glu Glu Asp Lys Ala Gly Phe Ile Lys Arg Gln 
        915                 920                 925             


Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gly Ile Leu His 
    930                 935                 940                 


His Arg Phe Asn Lys Ala Glu Asp Thr Asn Glu Pro Ile Arg Lys Val 
945                 950                 955                 960 


Arg Ile Ile Thr Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Asn Arg 
                965                 970                 975     


Phe Gly Ile Tyr Lys Val Arg Glu Ile Asn Glu Tyr His His Ala His 
            980                 985                 990         


Asp Ala Tyr Leu Asn Gly Val Val  Ala Leu Ala Leu Leu  Lys Lys Tyr 
        995                 1000                 1005             


Pro Gln  Leu Ala Pro Glu Phe  Val Tyr Gly Glu Tyr  Leu Lys Phe 
    1010                 1015                 1020             


Asn Ala  His Lys Ala Asn Lys  Ala Thr Val Lys Lys  Glu Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Lys Phe Phe  Glu Ser Asp Thr Pro  Val Cys Asp 
    1040                 1045                 1050             


Glu Asn  Gly Glu Ile Phe Trp  Asp Lys Ser Lys Ser  Ile Ala Gln 
    1055                 1060                 1065             


Val Lys  Lys Val Ile Asn His  His His Met Asn Ile  Val Lys Lys 
    1070                 1075                 1080             


Thr Glu  Ile Gln Lys Gly Gly  Phe Ser Lys Glu Thr  Val Glu Pro 
    1085                 1090                 1095             


Lys Lys  Asp Ser Ser Lys Leu  Leu Pro Arg Lys Asn  Asn Trp Asp 
    1100                 1105                 1110             


Pro Ala  Lys Tyr Gly Gly Leu  Gly Ser Pro Asn Val  Ala Tyr Thr 
    1115                 1120                 1125             


Val Ala  Phe Thr Tyr Glu Lys  Gly Lys Ala Arg Lys  Arg Thr Asn 
    1130                 1135                 1140             


Ala Leu  Glu Gly Ile Thr Ile  Met Glu Arg Glu Ala  Phe Glu Gln 
    1145                 1150                 1155             


Ser Pro  Val Leu Phe Leu Lys  Asn Lys Gly Tyr Glu  Gln Ala Glu 
    1160                 1165                 1170             


Ile Glu  Met Lys Leu Pro Lys  Tyr Ala Leu Phe Glu  Leu Glu Asn 
    1175                 1180                 1185             


Gly Arg  Lys Arg Met Val Ala  Ser Asn Lys Glu Ala  Gln Lys Ala 
    1190                 1195                 1200             


Asn Ser  Phe Leu Leu Pro Glu  His Leu Val Thr Leu  Leu Tyr His 
    1205                 1210                 1215             


Ala Lys  Gln Tyr Asp Glu Ile  Ser His Lys Glu Ser  Phe Asp Tyr 
    1220                 1225                 1230             


Val Asn  Glu His His Lys Glu  Phe Ser Glu Val Phe  Ala Arg Val 
    1235                 1240                 1245             


Leu Glu  Phe Ala Gly Lys Tyr  Thr Leu Ala Glu Lys  Asn Ile Glu 
    1250                 1255                 1260             


Lys Leu  Glu Lys Ile Tyr Lys  Glu Asn Gln Thr Asp  Asp Leu Ala 
    1265                 1270                 1275             


Lys Leu  Ala Ser Ser Phe Val  Asn Leu Met Gln Phe  Asn Ala Met 
    1280                 1285                 1290             


Gly Ala  Pro Ala Asp Phe Lys  Phe Phe Asp Val Thr  Ile Pro Arg 
    1295                 1300                 1305             


Lys Arg  Tyr Thr Ser Leu Thr  Glu Ile Trp Gln Ser  Thr Ile Ile 
    1310                 1315                 1320             


His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr Arg Ile  Arg Met Gly 
    1325                 1330                 1335             


Lys 
    


<210> 201
<211> 1340
<212> PRT
<213> Enterococcus faecium


<220>
<223> Enterococcus faecium 1,231,408

<400> 201
Met Lys Lys Glu Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Val Leu Thr Asp Asp Tyr Arg Leu Val Ser Lys Lys Met 
            20                  25                  30          


Lys Val Ala Gly Asn Thr Glu Lys Ser Ser Thr Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Glu Gly Gln Thr Ala Glu Ala Arg Arg Ser 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Leu Ala Arg Arg Arg Gln Arg Ile Leu 
65                  70                  75                  80  


Glu Leu Gln Lys Ile Phe Ala Pro Glu Ile Leu Lys Ile Asp Glu His 
                85                  90                  95      


Phe Phe Ala Arg Leu Asn Glu Ser Phe Leu Val Pro Asp Glu Lys Lys 
            100                 105                 110         


Gln Ser Arg His Pro Val Phe Ala Thr Ile Lys Gln Glu Lys Ser Tyr 
        115                 120                 125             


His Gln Thr Tyr Pro Thr Ile Tyr His Leu Arg Gln Ala Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Ile Arg Leu Val Tyr Leu Ala Met Ala His 
145                 150                 155                 160 


Leu Leu Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Thr 
                165                 170                 175     


Glu Asn Ser Ser Val Thr Glu Thr Phe Arg Gln Phe Leu Ser Thr Tyr 
            180                 185                 190         


Asn Gln Gln Phe Ser Glu Ala Gly Asp Lys Gln Thr Glu Lys Leu Asp 
        195                 200                 205             


Glu Ala Val Asp Cys Ser Phe Val Phe Thr Glu Lys Met Ser Lys Thr 
    210                 215                 220                 


Lys Lys Ala Glu Thr Leu Leu Lys Tyr Phe Pro His Glu Lys Ser Asn 
225                 230                 235                 240 


Gly Tyr Leu Ser Gln Phe Ile Lys Leu Met Val Gly Asn Gln Gly Asn 
                245                 250                 255     


Phe Lys Asn Val Phe Gly Leu Glu Glu Glu Ala Lys Leu Gln Phe Ser 
            260                 265                 270         


Lys Glu Thr Tyr Glu Glu Asp Leu Glu Glu Leu Leu Glu Lys Ile Gly 
        275                 280                 285             


Asp Asp Tyr Ile Asp Leu Phe Val Gln Ala Lys Asn Val Tyr Asp Ala 
    290                 295                 300                 


Val Leu Leu Ser Glu Ile Leu Ser Asp Ser Thr Lys Asn Thr Arg Ala 
305                 310                 315                 320 


Lys Leu Ser Ala Gly Met Ile Arg Arg Tyr Asp Ala His Lys Glu Asp 
                325                 330                 335     


Leu Val Leu Leu Lys Arg Phe Val Lys Glu Asn Leu Pro Lys Lys Tyr 
            340                 345                 350         


Arg Ala Phe Phe Gly Asp Asn Ser Val Asn Gly Tyr Ala Gly Tyr Ile 
        355                 360                 365             


Glu Gly His Ala Thr Gln Glu Ala Phe Tyr Lys Phe Val Lys Lys Glu 
    370                 375                 380                 


Leu Thr Gly Ile Arg Gly Ser Glu Val Phe Leu Thr Lys Ile Glu Gln 
385                 390                 395                 400 


Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Val Ile Pro 
                405                 410                 415     


His Gln Ile His Leu Ser Glu Leu Arg Ala Ile Ile Ala Asn Gln Lys 
            420                 425                 430         


Lys His Tyr Pro Phe Leu Lys Glu Glu Gln Glu Lys Leu Glu Ser Leu 
        435                 440                 445             


Leu Thr Phe Lys Ile Pro Tyr Tyr Val Gly Pro Leu Ala Lys Lys Gln 
    450                 455                 460                 


Glu Asn Ser Pro Phe Ala Trp Leu Ile Arg Lys Ser Glu Glu Lys Ile 
465                 470                 475                 480 


Lys Pro Trp Asn Leu Pro Glu Ile Val Asp Met Glu Gly Ser Ala Val 
                485                 490                 495     


Arg Phe Ile Glu Arg Met Ile Asn Thr Asp Met Tyr Met Pro His Asn 
            500                 505                 510         


Lys Val Leu Pro Lys Asn Ser Leu Leu Tyr Gln Lys Phe Ser Ile Tyr 
        515                 520                 525             


Asn Glu Leu Thr Lys Val Arg Tyr Gln Asp Glu Arg Gly Gln Met Asn 
    530                 535                 540                 


Tyr Phe Ser Ser Ile Glu Lys Lys Glu Ile Phe His Glu Leu Phe Glu 
545                 550                 555                 560 


Lys Asn Arg Lys Val Thr Lys Lys Asp Leu Gln Glu Phe Leu Tyr Leu 
                565                 570                 575     


Lys Tyr Asp Ile Lys His Ala Glu Leu Ser Gly Ile Glu Lys Ala Phe 
            580                 585                 590         


Asn Ala Ser Tyr Thr Thr Tyr His Asp Phe Leu Thr Met Ser Glu Asn 
        595                 600                 605             


Lys Arg Glu Met Lys Gln Trp Leu Glu Asp Pro Glu Leu Ala Ser Met 
    610                 615                 620                 


Phe Glu Glu Ile Ile Lys Thr Leu Thr Val Phe Glu Asp Arg Glu Met 
625                 630                 635                 640 


Ile Lys Thr Arg Leu Ser His His Glu Ala Thr Leu Gly Lys His Ile 
                645                 650                 655     


Ile Lys Lys Leu Thr Lys Lys His Tyr Thr Gly Trp Gly Arg Leu Ser 
            660                 665                 670         


Lys Glu Leu Ile Gln Gly Ile Arg Asp Lys Gln Ser Asn Lys Thr Ile 
        675                 680                 685             


Leu Asp Tyr Leu Ile Asn Asp Asp Asp Phe Pro His His Arg Asn Arg 
    690                 695                 700                 


Asn Phe Met Gln Leu Ile Asn Asp Asp Ser Leu Ser Phe Lys Lys Glu 
705                 710                 715                 720 


Ile Lys Lys Ala Gln Met Ile Thr Asp Thr Glu Asn Leu Glu Glu Ile 
                725                 730                 735     


Val Lys Glu Leu Thr Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln 
            740                 745                 750         


Ser Leu Lys Ile Val Asp Glu Ile Val Gly Ile Met Gly Tyr Glu Pro 
        755                 760                 765             


Ala Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Gly Arg 
    770                 775                 780                 


Gly Leu Lys Ser Ser Arg Pro Arg Leu Lys Ala Leu Glu Glu Ser Leu 
785                 790                 795                 800 


Lys Asp Phe Gly Ser Gln Leu Leu Lys Glu Tyr Pro Thr Asp Asn Ser 
                805                 810                 815     


Ser Leu Gln Lys Asp Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg 
            820                 825                 830         


Asp Met Tyr Thr Gly Ala Pro Leu Asp Ile His Arg Leu Ser Asp Tyr 
        835                 840                 845             


Asp Ile Asp His Ile Ile Pro Arg Ser Phe Thr Thr Asp Asn Ser Ile 
    850                 855                 860                 


Asp Asn Lys Val Leu Val Ser Ser Lys Glu Asn Arg Leu Lys Lys Asp 
865                 870                 875                 880 


Asp Val Pro Ser Glu Lys Val Val Lys Lys Met Arg Ser Phe Trp Tyr 
                885                 890                 895     


Asp Leu Tyr Ser Ser Lys Leu Ile Ser Lys Arg Lys Leu Asp Asn Leu 
            900                 905                 910         


Thr Lys Ile Lys Leu Thr Glu Glu Asp Lys Ala Gly Phe Ile Lys Arg 
        915                 920                 925             


Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gly Ile Leu 
    930                 935                 940                 


His His Arg Phe Asn Lys Ala Glu Asp Thr Asn Asp Pro Ile Arg Lys 
945                 950                 955                 960 


Val Arg Ile Ile Thr Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Asn 
                965                 970                 975     


Arg Phe Gly Ile Tyr Lys Val Arg Glu Ile Asn Glu Tyr His His Ala 
            980                 985                 990         


His Asp Ala Tyr Leu Asn Gly Val  Val Ala Leu Ala Leu  Leu Lys Lys 
        995                 1000                 1005             


Tyr Pro  Gln Leu Ala Pro Glu  Phe Val Tyr Gly Glu  Tyr Leu Lys 
    1010                 1015                 1020             


Phe Asn  Ala His Lys Ala Asn  Lys Ala Thr Val Lys  Lys Glu Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Lys Phe  Phe Glu Ser Asp Thr  Pro Val Cys 
    1040                 1045                 1050             


Asp Glu  Asn Gly Glu Ile Phe  Trp Asp Lys Ser Lys  Ser Ile Ala 
    1055                 1060                 1065             


Gln Val  Lys Lys Val Ile Asn  His His His Met Asn  Ile Val Lys 
    1070                 1075                 1080             


Lys Thr  Glu Ile Gln Lys Gly  Gly Phe Ser Lys Glu  Thr Val Glu 
    1085                 1090                 1095             


Pro Lys  Lys Asp Ser Ser Lys  Leu Leu Pro Arg Lys  Asn Asn Trp 
    1100                 1105                 1110             


Asp Pro  Ala Lys Tyr Gly Gly  Leu Gly Ser Pro Asn  Val Ala Tyr 
    1115                 1120                 1125             


Thr Val  Ala Phe Thr Tyr Glu  Lys Gly Lys Ala Arg  Lys Arg Thr 
    1130                 1135                 1140             


Asn Ala  Leu Glu Gly Ile Thr  Ile Met Glu Arg Glu  Ala Phe Glu 
    1145                 1150                 1155             


Gln Ser  Pro Val Leu Phe Leu  Lys Asn Lys Gly Tyr  Glu Gln Ala 
    1160                 1165                 1170             


Glu Ile  Glu Met Lys Leu Pro  Lys Tyr Ala Leu Phe  Glu Leu Glu 
    1175                 1180                 1185             


Asn Gly  Arg Lys Arg Met Val  Ala Ser Asn Lys Glu  Ala Gln Lys 
    1190                 1195                 1200             


Ala Asn  Ser Phe Leu Leu Pro  Glu His Leu Val Thr  Leu Leu Tyr 
    1205                 1210                 1215             


His Ala  Lys Gln Tyr Asp Glu  Ile Ser His Lys Glu  Ser Phe Asp 
    1220                 1225                 1230             


Tyr Val  Asn Glu His His Lys  Glu Phe Ser Glu Val  Phe Ala Arg 
    1235                 1240                 1245             


Val Leu  Glu Phe Ala Gly Lys  Tyr Thr Leu Ala Glu  Lys Asn Ile 
    1250                 1255                 1260             


Glu Lys  Leu Glu Lys Ile Tyr  Lys Glu Asn Gln Thr  Asp Asp Leu 
    1265                 1270                 1275             


Ala Lys  Leu Ala Ser Ser Phe  Val Asn Leu Met Gln  Phe Asn Ala 
    1280                 1285                 1290             


Met Gly  Ala Pro Ala Asp Phe  Lys Phe Phe Asp Val  Thr Ile Pro 
    1295                 1300                 1305             


Arg Lys  Arg Tyr Thr Ser Leu  Thr Glu Ile Trp Gln  Ser Thr Ile 
    1310                 1315                 1320             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Arg Met 
    1325                 1330                 1335             


Gly Lys  
    1340 


<210> 202
<211> 1339
<212> PRT
<213> Enterococcus faecium


<220>
<223> Enterococcus faecium E1133

<400> 202
Met Lys Lys Glu Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Val Leu Thr Asp Asp Tyr Arg Leu Val Ser Lys Lys Met 
            20                  25                  30          


Lys Val Ala Gly Asn Thr Glu Lys Ser Ser Thr Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Glu Gly Gln Thr Ala Glu Ala Arg Arg Ser 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Leu Ala Arg Arg Arg Gln Arg Ile Leu 
65                  70                  75                  80  


Glu Leu Gln Lys Ile Phe Ala Pro Glu Ile Leu Lys Ile Asp Glu His 
                85                  90                  95      


Phe Phe Ala Arg Leu Asn Glu Ser Phe Leu Val Leu Asp Glu Lys Lys 
            100                 105                 110         


Gln Ser Arg His Pro Val Phe Ala Thr Ile Lys Gln Glu Lys Ser Tyr 
        115                 120                 125             


His Gln Thr Tyr Pro Thr Ile Tyr His Leu Arg Gln Ala Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Ile Arg Leu Val Tyr Leu Ala Met Ala His 
145                 150                 155                 160 


Leu Leu Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Thr 
                165                 170                 175     


Glu Asn Ser Ser Val Thr Glu Thr Phe Arg Gln Phe Leu Ser Thr Tyr 
            180                 185                 190         


Asn Gln Gln Phe Ser Glu Ala Asp Asp Lys Gln Thr Glu Lys Leu Asp 
        195                 200                 205             


Glu Ala Val Asp Cys Ser Phe Val Phe Thr Glu Lys Met Ser Lys Thr 
    210                 215                 220                 


Lys Lys Ala Glu Thr Leu Leu Lys Tyr Phe Pro His Glu Lys Ser Asn 
225                 230                 235                 240 


Gly Tyr Leu Ser Gln Phe Ile Lys Leu Met Val Gly Asn Gln Gly Asn 
                245                 250                 255     


Phe Lys Asn Val Phe Gly Leu Glu Glu Ala Lys Leu Gln Phe Ser Lys 
            260                 265                 270         


Glu Thr Tyr Glu Glu Asp Leu Glu Glu Leu Leu Glu Lys Ile Gly Asp 
        275                 280                 285             


Asp Tyr Ile Asp Leu Phe Val Gln Ala Lys Asn Val Tyr Asp Ala Val 
    290                 295                 300                 


Leu Leu Ser Glu Ile Leu Ser Asp Ser Thr Lys Asn Thr Arg Ala Lys 
305                 310                 315                 320 


Leu Ser Ala Gly Met Ile Arg Arg Tyr Asp Ala His Lys Glu Asp Leu 
                325                 330                 335     


Val Leu Leu Lys Arg Phe Val Lys Glu Asn Leu Pro Lys Lys Tyr Arg 
            340                 345                 350         


Ala Phe Phe Gly Asp Asn Ser Val Asn Gly Tyr Ala Gly Tyr Ile Glu 
        355                 360                 365             


Gly His Ala Thr Gln Glu Asp Phe Tyr Lys Phe Val Lys Lys Glu Leu 
    370                 375                 380                 


Thr Gly Ile Arg Gly Ser Glu Val Phe Leu Thr Lys Ile Glu Gln Glu 
385                 390                 395                 400 


Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Val Ile Pro His 
                405                 410                 415     


Gln Ile His Leu Thr Glu Leu Arg Ala Ile Ile Ala Asn Gln Lys Lys 
            420                 425                 430         


His Tyr Pro Phe Leu Lys Glu Glu Gln Glu Lys Leu Glu Ser Leu Leu 
        435                 440                 445             


Thr Phe Lys Ile Pro Tyr Tyr Val Gly Pro Leu Ala Lys Lys Gln Glu 
    450                 455                 460                 


Asn Ser Pro Phe Ala Trp Leu Ile Arg Lys Ser Glu Glu Lys Ile Lys 
465                 470                 475                 480 


Pro Trp Asn Leu Pro Glu Ile Val Asp Met Glu Gly Ser Ala Val Arg 
                485                 490                 495     


Phe Ile Glu Arg Met Ile Asn Thr Asp Met Tyr Ile Pro His Asn Lys 
            500                 505                 510         


Val Leu Pro Lys Asn Ser Leu Leu Tyr Gln Lys Phe Ser Ile Tyr Asn 
        515                 520                 525             


Glu Leu Thr Lys Val Arg Tyr Gln Asp Glu Arg Gly Gln Met Asn Tyr 
    530                 535                 540                 


Phe Ser Ser Ile Glu Lys Lys Glu Ile Phe His Glu Leu Phe Glu Lys 
545                 550                 555                 560 


Asn Arg Lys Val Thr Lys Lys Asp Leu Gln Glu Phe Leu Tyr Leu Lys 
                565                 570                 575     


Tyr Asp Ile Lys His Ala Glu Leu Ser Gly Ile Glu Lys Ala Phe Asn 
            580                 585                 590         


Ala Ser Tyr Thr Thr Tyr His Asp Phe Leu Thr Met Ser Glu Asn Lys 
        595                 600                 605             


Arg Glu Met Lys Gln Trp Leu Glu Asp Pro Glu Leu Ala Ser Met Phe 
    610                 615                 620                 


Glu Glu Ile Ile Lys Thr Leu Thr Val Phe Glu Asp Arg Glu Met Ile 
625                 630                 635                 640 


Lys Thr Arg Leu Ser His His Glu Ala Thr Leu Gly Lys His Ile Ile 
                645                 650                 655     


Lys Lys Leu Thr Lys Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 
            660                 665                 670         


Glu Leu Ile Gln Gly Ile Arg Asp Lys Gln Ser Asn Lys Thr Ile Leu 
        675                 680                 685             


Asp Tyr Leu Ile Asn Asp Asp Asp Phe Pro His His Arg Asn Arg Asn 
    690                 695                 700                 


Phe Met Gln Leu Ile Asn Asp Asp Ser Leu Ser Phe Lys Lys Glu Ile 
705                 710                 715                 720 


Lys Lys Ala Gln Met Ile Thr Asp Thr Glu Asn Leu Glu Glu Ile Val 
                725                 730                 735     


Lys Glu Leu Thr Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Ser 
            740                 745                 750         


Leu Lys Ile Val Asp Glu Ile Val Gly Ile Met Gly Tyr Glu Pro Ala 
        755                 760                 765             


Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Gly Arg Gly 
    770                 775                 780                 


Leu Lys Ser Ser Arg Pro Arg Leu Lys Ala Leu Glu Glu Ser Leu Lys 
785                 790                 795                 800 


Asp Phe Gly Ser Gln Leu Leu Lys Glu Tyr Pro Thr Asp Asn Ser Ser 
                805                 810                 815     


Leu Gln Lys Asp Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp 
            820                 825                 830         


Met Tyr Thr Gly Ala Pro Leu Asp Ile His Arg Leu Ser Asp Tyr Asp 
        835                 840                 845             


Ile Asp His Ile Ile Pro Arg Ser Phe Thr Thr Asp Asn Ser Ile Asp 
    850                 855                 860                 


Asn Lys Val Leu Val Ser Ser Lys Glu Asn Arg Leu Lys Lys Asp Asp 
865                 870                 875                 880 


Val Pro Ser Glu Lys Val Val Lys Lys Met Arg Ser Phe Trp Tyr Asp 
                885                 890                 895     


Leu Tyr Ser Ser Lys Leu Ile Ser Lys Arg Lys Leu Asp Asn Leu Thr 
            900                 905                 910         


Lys Ile Lys Leu Thr Glu Glu Asp Lys Ala Gly Phe Ile Lys Arg Gln 
        915                 920                 925             


Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gly Ile Leu His 
    930                 935                 940                 


His Arg Phe Asn Lys Ala Glu Asp Thr Asn Glu Pro Ile Arg Lys Val 
945                 950                 955                 960 


Arg Ile Ile Thr Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Asn Arg 
                965                 970                 975     


Phe Gly Ile Tyr Lys Val Arg Glu Ile Asn Glu Tyr His His Ala His 
            980                 985                 990         


Asp Ala Tyr Leu Asn Gly Val Val  Ala Leu Ala Leu Leu  Lys Lys Tyr 
        995                 1000                 1005             


Pro Gln  Leu Ala Pro Glu Phe  Val Tyr Gly Glu Tyr  Leu Lys Phe 
    1010                 1015                 1020             


Asn Ala  His Lys Ala Asn Lys  Ala Thr Val Lys Lys  Glu Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Lys Phe Phe  Glu Ser Asp Thr Pro  Val Cys Asp 
    1040                 1045                 1050             


Glu Asn  Gly Glu Ile Phe Trp  Asp Lys Ser Lys Ser  Ile Ala Gln 
    1055                 1060                 1065             


Val Lys  Lys Val Ile Asn His  His His Met Asn Ile  Val Lys Lys 
    1070                 1075                 1080             


Thr Glu  Ile Gln Lys Gly Gly  Phe Ser Glu Glu Thr  Val Glu Pro 
    1085                 1090                 1095             


Lys Lys  Asp Ser Ser Lys Leu  Leu Pro Arg Lys Asn  Asn Trp Asp 
    1100                 1105                 1110             


Pro Ala  Lys Tyr Gly Gly Leu  Gly Ser Pro Asn Val  Ala Tyr Thr 
    1115                 1120                 1125             


Val Ala  Phe Thr Tyr Glu Lys  Gly Lys Ala Arg Lys  Arg Thr Asn 
    1130                 1135                 1140             


Ala Leu  Glu Gly Ile Thr Ile  Met Glu Arg Glu Ala  Phe Glu Gln 
    1145                 1150                 1155             


Ser Pro  Val Leu Phe Leu Lys  Asn Lys Gly Tyr Glu  Gln Ala Glu 
    1160                 1165                 1170             


Ile Glu  Met Lys Leu Pro Lys  Tyr Ala Leu Phe Glu  Leu Glu Asn 
    1175                 1180                 1185             


Gly Arg  Lys Arg Met Val Ala  Ser Asn Lys Glu Ala  Gln Lys Ala 
    1190                 1195                 1200             


Asn Ser  Phe Leu Leu Pro Glu  His Leu Val Thr Leu  Leu Tyr His 
    1205                 1210                 1215             


Ala Lys  Gln Tyr Asp Glu Ile  Ser His Lys Glu Ser  Phe Asp Tyr 
    1220                 1225                 1230             


Val Asn  Glu His His Lys Glu  Phe Ser Glu Val Phe  Ala Arg Val 
    1235                 1240                 1245             


Leu Glu  Phe Ala Gly Lys Tyr  Thr Leu Ala Glu Lys  Asn Ile Glu 
    1250                 1255                 1260             


Lys Leu  Glu Lys Ile Tyr Lys  Glu Asn Gln Thr Asp  Asp Leu Ala 
    1265                 1270                 1275             


Lys Leu  Ala Ser Ser Phe Val  Asn Leu Met Gln Phe  Asn Ala Met 
    1280                 1285                 1290             


Gly Ala  Pro Ala Asp Phe Lys  Phe Phe Asp Val Thr  Ile Pro Arg 
    1295                 1300                 1305             


Lys Arg  Tyr Thr Ser Leu Thr  Glu Ile Trp Gln Ser  Thr Ile Ile 
    1310                 1315                 1320             


His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr Arg Ile  Arg Met Gly 
    1325                 1330                 1335             


Lys 
    


<210> 203
<211> 1340
<212> PRT
<213> Enterococcus faecium


<220>
<223> Enterococcus faecium E3083

<400> 203
Met Lys Lys Glu Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Val Leu Thr Asp Asp Tyr Arg Leu Val Ser Lys Lys Met 
            20                  25                  30          


Lys Val Ala Gly Asn Thr Glu Lys Ser Ser Thr Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Glu Gly Gln Thr Ala Glu Ala Arg Arg Ser 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Leu Ala Arg Arg Arg Gln Arg Ile Leu 
65                  70                  75                  80  


Glu Leu Gln Lys Ile Phe Ala Pro Glu Ile Leu Lys Ile Asp Glu His 
                85                  90                  95      


Phe Phe Ala Arg Leu Asn Glu Ser Phe Leu Val Leu Asp Glu Lys Lys 
            100                 105                 110         


Gln Ser Arg His Pro Val Phe Ala Thr Ile Lys Gln Glu Lys Ser Tyr 
        115                 120                 125             


His Gln Thr Tyr Pro Thr Ile Tyr His Leu Arg Gln Ala Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Ile Arg Leu Val Tyr Leu Ala Met Ala His 
145                 150                 155                 160 


Leu Leu Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Thr 
                165                 170                 175     


Glu Asn Ser Ser Val Thr Glu Thr Phe Arg Gln Phe Leu Ser Thr Tyr 
            180                 185                 190         


Asn Gln Gln Phe Ser Glu Ala Asp Asp Lys Gln Thr Glu Lys Leu Asp 
        195                 200                 205             


Glu Ala Val Asp Cys Ser Phe Val Phe Thr Glu Lys Met Ser Lys Thr 
    210                 215                 220                 


Lys Lys Ala Glu Thr Leu Leu Lys Tyr Phe Pro His Glu Lys Ser Asn 
225                 230                 235                 240 


Gly Tyr Leu Ser Gln Phe Ile Lys Leu Met Val Gly Asn Gln Gly Asn 
                245                 250                 255     


Phe Lys Asn Val Phe Gly Leu Glu Glu Glu Ala Lys Leu Gln Phe Ser 
            260                 265                 270         


Lys Glu Thr Tyr Glu Glu Asp Leu Glu Glu Leu Leu Glu Lys Ile Gly 
        275                 280                 285             


Asp Asp Tyr Ile Asp Leu Phe Val Gln Ala Lys Asn Val Tyr Asp Ala 
    290                 295                 300                 


Val Leu Leu Ser Glu Ile Leu Ser Asp Ser Thr Lys Asn Thr Arg Ala 
305                 310                 315                 320 


Lys Leu Ser Ala Gly Met Ile Arg Arg Tyr Asp Ala His Lys Glu Asp 
                325                 330                 335     


Leu Val Leu Leu Lys Arg Phe Val Lys Glu Asn Leu Pro Lys Lys Tyr 
            340                 345                 350         


Arg Ala Phe Phe Gly Asp Asn Ser Val Asn Gly Tyr Ala Gly Tyr Ile 
        355                 360                 365             


Glu Gly His Ala Thr Gln Glu Asp Phe Tyr Lys Phe Val Lys Lys Glu 
    370                 375                 380                 


Leu Thr Gly Ile Arg Gly Ser Glu Val Phe Leu Thr Lys Ile Glu Gln 
385                 390                 395                 400 


Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Val Ile Pro 
                405                 410                 415     


His Gln Ile His Leu Thr Glu Leu Arg Ala Ile Ile Ala Asn Gln Lys 
            420                 425                 430         


Lys His Tyr Pro Phe Leu Lys Glu Glu Gln Glu Lys Leu Glu Ser Leu 
        435                 440                 445             


Leu Thr Phe Lys Ile Pro Tyr Tyr Val Gly Pro Leu Ala Lys Lys Gln 
    450                 455                 460                 


Glu Asn Ser Pro Phe Ala Trp Leu Ile Arg Lys Ser Glu Glu Lys Ile 
465                 470                 475                 480 


Lys Pro Trp Asn Leu Pro Glu Ile Val Asp Met Glu Gly Ser Ala Val 
                485                 490                 495     


Arg Phe Ile Glu Arg Met Ile Asn Thr Asp Met Tyr Ile Pro His Asn 
            500                 505                 510         


Lys Val Leu Pro Lys Asn Ser Leu Leu Tyr Gln Lys Phe Ser Ile Tyr 
        515                 520                 525             


Asn Glu Leu Thr Lys Val Arg Tyr Gln Asp Glu Arg Gly Gln Met Asn 
    530                 535                 540                 


Tyr Phe Ser Ser Ile Glu Lys Lys Glu Ile Phe His Glu Leu Phe Glu 
545                 550                 555                 560 


Lys Asn Arg Lys Val Thr Lys Lys Asp Leu Gln Glu Phe Leu Tyr Leu 
                565                 570                 575     


Lys Tyr Asp Ile Lys His Ala Glu Leu Ser Gly Ile Glu Lys Ala Phe 
            580                 585                 590         


Asn Ala Ser Tyr Thr Thr Tyr His Asp Phe Leu Thr Met Ser Glu Asn 
        595                 600                 605             


Lys Arg Glu Met Lys Gln Trp Leu Glu Asp Pro Glu Leu Ala Ser Met 
    610                 615                 620                 


Phe Glu Glu Ile Ile Lys Thr Leu Thr Val Phe Glu Asp Arg Glu Met 
625                 630                 635                 640 


Ile Lys Thr Arg Leu Ser His His Glu Ala Thr Leu Gly Lys His Ile 
                645                 650                 655     


Ile Lys Lys Leu Thr Lys Lys His Tyr Thr Gly Trp Gly Arg Leu Ser 
            660                 665                 670         


Lys Glu Leu Ile Gln Gly Ile Arg Asp Lys Gln Ser Asn Lys Thr Ile 
        675                 680                 685             


Leu Asp Tyr Leu Ile Asn Asp Asp Asp Phe Pro His His Arg Asn Arg 
    690                 695                 700                 


Asn Cys Met Gln Leu Ile Asn Asp Asp Ser Leu Ser Phe Lys Lys Glu 
705                 710                 715                 720 


Ile Lys Lys Ala Gln Met Ile Thr Asp Thr Glu Asn Leu Glu Glu Ile 
                725                 730                 735     


Val Lys Glu Leu Thr Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln 
            740                 745                 750         


Ser Leu Lys Ile Val Asp Glu Ile Val Gly Ile Met Gly Tyr Glu Pro 
        755                 760                 765             


Ala Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Gly Arg 
    770                 775                 780                 


Gly Leu Lys Ser Ser Arg Pro Arg Leu Lys Ala Leu Glu Glu Ser Leu 
785                 790                 795                 800 


Lys Asp Phe Gly Ser Gln Leu Leu Lys Glu Tyr Pro Thr Asp Asn Ser 
                805                 810                 815     


Ser Leu Gln Lys Asp Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg 
            820                 825                 830         


Asp Met Tyr Thr Gly Ala Pro Leu Asp Ile His Arg Leu Ser Asp Tyr 
        835                 840                 845             


Asp Ile Asp His Ile Ile Pro Arg Ser Phe Thr Thr Asp Asn Ser Ile 
    850                 855                 860                 


Asp Asn Lys Val Leu Val Ser Ser Lys Glu Asn Arg Leu Lys Lys Asp 
865                 870                 875                 880 


Asp Val Pro Ser Glu Lys Val Val Lys Lys Met Arg Ser Phe Trp Tyr 
                885                 890                 895     


Asp Leu Tyr Ser Ser Lys Leu Ile Ser Lys Arg Lys Leu Asp Asn Leu 
            900                 905                 910         


Thr Lys Ile Lys Leu Thr Glu Glu Asp Lys Ala Gly Phe Ile Lys Arg 
        915                 920                 925             


Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gly Ile Leu 
    930                 935                 940                 


His His Arg Phe Asn Lys Ala Glu Asp Thr Asn Glu Pro Ile Arg Lys 
945                 950                 955                 960 


Val Arg Ile Ile Thr Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Asn 
                965                 970                 975     


Arg Phe Gly Ile Tyr Lys Val Arg Glu Ile Asn Glu Tyr His His Ala 
            980                 985                 990         


His Asp Ala Tyr Leu Asn Gly Val  Val Ala Leu Ala Leu  Leu Lys Lys 
        995                 1000                 1005             


Tyr Pro  Gln Leu Ala Pro Glu  Phe Val Tyr Gly Glu  Tyr Leu Lys 
    1010                 1015                 1020             


Phe Asn  Ala His Lys Ala Asn  Lys Ala Thr Val Lys  Lys Glu Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Lys Phe  Phe Glu Ser Asp Thr  Pro Val Cys 
    1040                 1045                 1050             


Asp Glu  Asn Gly Glu Ile Phe  Trp Asp Lys Ser Lys  Ser Ile Ala 
    1055                 1060                 1065             


Gln Val  Lys Lys Val Ile Asn  His His His Met Asn  Ile Val Lys 
    1070                 1075                 1080             


Lys Thr  Glu Ile Gln Lys Gly  Gly Phe Ser Lys Glu  Thr Val Glu 
    1085                 1090                 1095             


Pro Lys  Lys Asp Ser Ser Lys  Leu Leu Pro Arg Lys  Asn Asn Trp 
    1100                 1105                 1110             


Asp Pro  Thr Lys Tyr Gly Gly  Leu Gly Ser Pro Asn  Val Ala Tyr 
    1115                 1120                 1125             


Thr Val  Ala Phe Thr Tyr Glu  Lys Gly Lys Ala Arg  Lys Arg Thr 
    1130                 1135                 1140             


Asn Ala  Leu Glu Gly Ile Thr  Ile Met Glu Arg Glu  Ala Phe Glu 
    1145                 1150                 1155             


Gln Ser  Pro Val Leu Phe Leu  Lys Asn Lys Gly Tyr  Glu Gln Ala 
    1160                 1165                 1170             


Glu Ile  Glu Met Lys Leu Pro  Lys Tyr Ala Leu Phe  Glu Leu Glu 
    1175                 1180                 1185             


Asn Gly  Arg Lys Arg Met Val  Ala Ser Asn Lys Glu  Ala Gln Lys 
    1190                 1195                 1200             


Ala Asn  Ser Phe Leu Leu Pro  Glu His Leu Val Thr  Leu Leu Tyr 
    1205                 1210                 1215             


His Ala  Lys Gln Tyr Asp Glu  Ile Ser His Lys Glu  Ser Phe Asp 
    1220                 1225                 1230             


Tyr Val  Asn Glu His His Lys  Glu Phe Ser Glu Val  Phe Ala Arg 
    1235                 1240                 1245             


Val Leu  Glu Phe Ala Gly Lys  Tyr Thr Leu Ala Glu  Lys Asn Ile 
    1250                 1255                 1260             


Glu Lys  Leu Glu Lys Ile Tyr  Lys Glu Asn Gln Thr  Asp Asp Leu 
    1265                 1270                 1275             


Ala Lys  Leu Ala Ser Ser Phe  Val Asn Leu Met Gln  Phe Asn Ala 
    1280                 1285                 1290             


Met Gly  Ala Pro Ala Asp Phe  Lys Phe Phe Asp Val  Thr Ile Pro 
    1295                 1300                 1305             


Arg Lys  Arg Tyr Thr Ser Leu  Thr Glu Ile Trp Gln  Ser Thr Ile 
    1310                 1315                 1320             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Arg Met 
    1325                 1330                 1335             


Gly Lys  
    1340 


<210> 204
<211> 1340
<212> PRT
<213> Enterococcus faecium


<220>
<223> Enterococcus faecium PC4.1

<400> 204
Met Lys Lys Glu Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Val Leu Thr Asp Asp Tyr Arg Leu Val Ser Lys Lys Met 
            20                  25                  30          


Lys Val Ala Gly Asn Thr Glu Lys Ser Ser Thr Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Glu Gly Gln Thr Ala Glu Ala Arg Arg Ser 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Leu Ala Arg Arg Arg Gln Arg Ile Leu 
65                  70                  75                  80  


Glu Leu Gln Lys Ile Phe Ala Pro Glu Ile Leu Lys Ile Asp Glu His 
                85                  90                  95      


Phe Phe Ala Arg Leu Asn Glu Ser Phe Leu Val Leu Asp Glu Lys Lys 
            100                 105                 110         


Gln Ser Arg His Pro Val Phe Ala Thr Ile Lys Gln Glu Lys Ser Tyr 
        115                 120                 125             


His Gln Thr Tyr Pro Thr Ile Tyr His Leu Arg Gln Ala Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Ile Arg Leu Val Tyr Leu Ala Met Ala His 
145                 150                 155                 160 


Leu Leu Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Thr 
                165                 170                 175     


Glu Asn Ser Ser Val Thr Glu Thr Phe Arg Gln Phe Leu Ser Thr Tyr 
            180                 185                 190         


Asn Gln Gln Phe Ser Glu Ala Asp Asp Lys Gln Thr Glu Lys Leu Asp 
        195                 200                 205             


Glu Ala Val Asp Cys Ser Phe Val Phe Thr Glu Lys Met Ser Lys Thr 
    210                 215                 220                 


Lys Lys Ala Glu Thr Leu Leu Lys Tyr Phe Pro His Glu Lys Ser Asn 
225                 230                 235                 240 


Gly Tyr Leu Ser Gln Phe Ile Lys Leu Met Val Gly Asn Gln Gly Asn 
                245                 250                 255     


Phe Lys Asn Val Phe Gly Leu Glu Glu Glu Ala Lys Leu Gln Phe Ser 
            260                 265                 270         


Lys Glu Thr Tyr Glu Glu Asp Leu Glu Glu Leu Leu Glu Lys Ile Gly 
        275                 280                 285             


Asp Asp Tyr Ile Asp Leu Phe Val Gln Ala Lys Asn Val Tyr Asp Ala 
    290                 295                 300                 


Val Leu Leu Ser Glu Ile Leu Ser Asp Ser Thr Lys Asn Thr Arg Ala 
305                 310                 315                 320 


Lys Leu Ser Ala Gly Met Ile Arg Arg Tyr Asp Ala His Lys Glu Asp 
                325                 330                 335     


Leu Val Leu Leu Lys Arg Phe Val Lys Glu Asn Leu Pro Lys Lys Tyr 
            340                 345                 350         


Arg Ala Phe Phe Gly Asp Asn Ser Val Asn Gly Tyr Ala Gly Tyr Ile 
        355                 360                 365             


Glu Gly His Ala Thr Gln Glu Asp Phe Tyr Lys Phe Val Lys Lys Glu 
    370                 375                 380                 


Leu Thr Gly Ile Arg Gly Ser Glu Val Phe Leu Thr Lys Ile Glu Gln 
385                 390                 395                 400 


Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Val Ile Pro 
                405                 410                 415     


His Gln Ile His Leu Thr Glu Leu Arg Ala Ile Ile Ala Asn Gln Lys 
            420                 425                 430         


Lys His Tyr Pro Phe Leu Lys Glu Glu Gln Glu Lys Leu Glu Ser Leu 
        435                 440                 445             


Leu Thr Phe Lys Ile Pro Tyr Tyr Val Gly Pro Leu Ala Lys Lys Gln 
    450                 455                 460                 


Glu Asn Ser Pro Phe Ala Trp Leu Ile Arg Lys Ser Glu Glu Lys Ile 
465                 470                 475                 480 


Lys Pro Trp Asn Leu Pro Glu Ile Val Asp Met Glu Gly Ser Ala Val 
                485                 490                 495     


Arg Phe Ile Glu Arg Met Ile Asn Thr Asp Met Tyr Ile Pro His Asn 
            500                 505                 510         


Lys Val Leu Pro Lys Asn Ser Leu Leu Tyr Gln Lys Phe Ser Ile Tyr 
        515                 520                 525             


Asn Glu Leu Thr Lys Val Arg Tyr Gln Asp Glu Arg Gly Gln Met Asn 
    530                 535                 540                 


Tyr Phe Ser Ser Ile Glu Lys Lys Glu Ile Phe His Glu Leu Phe Glu 
545                 550                 555                 560 


Lys Asn Arg Lys Val Thr Lys Lys Asp Leu Gln Glu Phe Leu Tyr Leu 
                565                 570                 575     


Lys Tyr Asp Ile Lys His Ala Glu Leu Ser Gly Ile Glu Lys Ala Phe 
            580                 585                 590         


Asn Ala Ser Tyr Thr Thr Tyr His Asp Phe Leu Thr Met Ser Glu Asn 
        595                 600                 605             


Lys Arg Glu Met Lys Gln Trp Leu Glu Asp Pro Glu Leu Ala Ser Met 
    610                 615                 620                 


Phe Glu Glu Ile Ile Lys Thr Leu Thr Val Phe Glu Asp Arg Glu Met 
625                 630                 635                 640 


Ile Lys Thr Arg Leu Ser His His Glu Ala Thr Leu Gly Lys His Ile 
                645                 650                 655     


Ile Lys Lys Leu Thr Lys Lys His Tyr Thr Gly Trp Gly Arg Leu Ser 
            660                 665                 670         


Lys Glu Leu Ile Gln Gly Ile Arg Asp Lys Gln Ser Asn Lys Thr Ile 
        675                 680                 685             


Leu Asp Tyr Leu Ile Asn Asp Asp Asp Phe Pro His His Arg Asn Arg 
    690                 695                 700                 


Asn Phe Met Gln Leu Ile Asn Asp Asp Ser Leu Ser Phe Lys Lys Glu 
705                 710                 715                 720 


Ile Lys Lys Ala Gln Met Ile Thr Asp Thr Glu Asn Leu Glu Glu Ile 
                725                 730                 735     


Val Lys Glu Leu Thr Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln 
            740                 745                 750         


Ser Leu Lys Ile Val Asp Glu Ile Val Gly Ile Met Gly Tyr Glu Pro 
        755                 760                 765             


Ala Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Gly Arg 
    770                 775                 780                 


Gly Leu Lys Ser Ser Arg Pro Arg Leu Lys Ala Leu Glu Glu Ser Leu 
785                 790                 795                 800 


Lys Asp Phe Gly Ser Gln Leu Leu Lys Glu Tyr Pro Thr Asp Asn Ser 
                805                 810                 815     


Ser Leu Gln Lys Asp Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg 
            820                 825                 830         


Asp Met Tyr Thr Gly Ala Pro Leu Asp Ile His Arg Leu Ser Asp Tyr 
        835                 840                 845             


Asp Ile Asp His Ile Ile Pro Arg Ser Phe Thr Thr Asp Asn Ser Ile 
    850                 855                 860                 


Asp Asn Lys Val Leu Val Ser Ser Lys Glu Asn Arg Leu Lys Lys Asp 
865                 870                 875                 880 


Asp Val Pro Ser Glu Lys Val Val Lys Lys Met Arg Ser Phe Trp Tyr 
                885                 890                 895     


Asp Leu Tyr Ser Ser Lys Leu Ile Ser Lys Arg Lys Leu Asp Asn Leu 
            900                 905                 910         


Thr Lys Ile Lys Leu Thr Glu Glu Asp Lys Ala Gly Phe Ile Lys Arg 
        915                 920                 925             


Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gly Ile Leu 
    930                 935                 940                 


His His Arg Phe Asn Lys Ala Glu Asp Thr Asn Glu Pro Ile Arg Lys 
945                 950                 955                 960 


Val Arg Ile Ile Thr Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Asn 
                965                 970                 975     


Arg Phe Gly Ile Tyr Lys Val Arg Glu Ile Asn Glu Tyr His His Ala 
            980                 985                 990         


His Asp Ala Tyr Leu Asn Gly Val  Val Ala Leu Ala Leu  Leu Lys Lys 
        995                 1000                 1005             


Tyr Pro  Gln Leu Ala Pro Glu  Phe Val Tyr Gly Glu  Tyr Leu Lys 
    1010                 1015                 1020             


Phe Asn  Ala His Lys Ala Asn  Lys Ala Thr Val Lys  Lys Glu Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Lys Phe  Phe Glu Ser Asp Thr  Pro Val Cys 
    1040                 1045                 1050             


Asp Glu  Asn Gly Glu Ile Phe  Trp Asp Lys Ser Lys  Ser Ile Ala 
    1055                 1060                 1065             


Gln Val  Lys Lys Val Ile Asn  His His His Met Asn  Ile Val Lys 
    1070                 1075                 1080             


Lys Thr  Glu Ile Gln Lys Gly  Gly Phe Ser Lys Glu  Thr Val Glu 
    1085                 1090                 1095             


Pro Lys  Lys Asp Ser Ser Lys  Leu Leu Pro Arg Lys  Asn Asn Trp 
    1100                 1105                 1110             


Asp Pro  Ala Lys Tyr Gly Gly  Leu Gly Ser Pro Asn  Val Ala Tyr 
    1115                 1120                 1125             


Thr Val  Ala Phe Thr Tyr Glu  Lys Gly Lys Ala Arg  Lys Arg Thr 
    1130                 1135                 1140             


Asn Ala  Leu Glu Gly Ile Thr  Ile Met Glu Arg Glu  Ala Phe Glu 
    1145                 1150                 1155             


Gln Ser  Pro Val Leu Phe Leu  Lys Asn Lys Gly Tyr  Glu Gln Ala 
    1160                 1165                 1170             


Glu Ile  Glu Met Lys Leu Pro  Lys Tyr Ala Leu Phe  Glu Leu Glu 
    1175                 1180                 1185             


Asn Gly  Arg Lys Arg Met Val  Ala Ser Asn Lys Glu  Ala Gln Lys 
    1190                 1195                 1200             


Ala Asn  Ser Phe Leu Leu Pro  Glu His Leu Val Thr  Leu Leu Tyr 
    1205                 1210                 1215             


His Ala  Lys Gln Tyr Asp Glu  Ile Ser His Lys Glu  Ser Phe Asp 
    1220                 1225                 1230             


Tyr Val  Asn Glu His His Lys  Glu Phe Ser Glu Val  Phe Ala Arg 
    1235                 1240                 1245             


Val Leu  Glu Phe Ala Gly Lys  Tyr Thr Leu Ala Glu  Lys Asn Ile 
    1250                 1255                 1260             


Glu Lys  Leu Glu Lys Ile Tyr  Lys Glu Asn Gln Thr  Asp Asp Leu 
    1265                 1270                 1275             


Ala Lys  Leu Ala Ser Ser Phe  Val Asn Leu Met Gln  Phe Asn Ala 
    1280                 1285                 1290             


Met Gly  Ala Pro Ala Asp Phe  Lys Phe Phe Asp Val  Thr Ile Pro 
    1295                 1300                 1305             


Arg Lys  Arg Tyr Thr Ser Leu  Thr Glu Ile Trp Gln  Ser Thr Ile 
    1310                 1315                 1320             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Arg Met 
    1325                 1330                 1335             


Gly Lys  
    1340 


<210> 205
<211> 1340
<212> PRT
<213> Enterococcus faecium


<220>
<223> Enterococcus faecium TX1330

<400> 205
Met Lys Lys Glu Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Val Leu Thr Asp Asp Tyr Arg Leu Val Ser Lys Lys Met 
            20                  25                  30          


Lys Val Ala Gly Asn Thr Glu Lys Ser Ser Thr Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Glu Gly Gln Thr Ala Glu Ala Arg Arg Ser 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Leu Ala Arg Arg Arg Gln Arg Ile Leu 
65                  70                  75                  80  


Glu Leu Gln Lys Ile Phe Ala Pro Glu Ile Leu Lys Ile Asp Glu His 
                85                  90                  95      


Phe Phe Ala Arg Leu Asn Glu Ser Phe Leu Val Leu Asp Glu Lys Lys 
            100                 105                 110         


Gln Ser Arg His Pro Val Phe Ala Thr Ile Lys Gln Glu Lys Ser Tyr 
        115                 120                 125             


His Gln Thr Tyr Pro Thr Ile Tyr His Leu Arg Gln Ala Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Ile Arg Leu Val Tyr Leu Ala Met Ala His 
145                 150                 155                 160 


Leu Leu Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Thr 
                165                 170                 175     


Glu Asn Ser Ser Val Thr Glu Thr Phe Arg Gln Phe Leu Ser Thr Tyr 
            180                 185                 190         


Asn Gln Gln Phe Ser Glu Ala Asp Asp Lys Gln Thr Glu Lys Leu Asp 
        195                 200                 205             


Glu Ala Val Asp Cys Ser Phe Val Phe Thr Glu Lys Met Ser Lys Thr 
    210                 215                 220                 


Lys Lys Ala Glu Thr Leu Leu Lys Tyr Phe Pro His Glu Lys Ser Asn 
225                 230                 235                 240 


Gly Tyr Leu Ser Gln Phe Ile Lys Leu Met Val Gly Asn Gln Gly Asn 
                245                 250                 255     


Phe Lys Asn Val Phe Gly Leu Glu Glu Glu Ala Lys Leu Gln Phe Ser 
            260                 265                 270         


Lys Glu Thr Tyr Glu Glu Asp Leu Glu Glu Leu Leu Glu Lys Ile Gly 
        275                 280                 285             


Asp Asp Tyr Ile Asp Leu Phe Val Gln Ala Lys Asn Val Tyr Asp Ala 
    290                 295                 300                 


Val Leu Leu Ser Glu Ile Leu Ser Asp Ser Thr Lys Asn Thr Arg Ala 
305                 310                 315                 320 


Lys Leu Ser Ala Gly Met Ile Arg Arg Tyr Asp Ala His Lys Glu Asp 
                325                 330                 335     


Leu Val Leu Leu Lys Arg Phe Val Lys Glu Asn Leu Pro Lys Lys Tyr 
            340                 345                 350         


Arg Ala Phe Phe Gly Asp Asn Ser Val Asn Gly Tyr Ala Gly Tyr Ile 
        355                 360                 365             


Glu Gly His Ala Thr Gln Glu Asp Phe Tyr Lys Phe Val Lys Lys Glu 
    370                 375                 380                 


Leu Thr Gly Ile Arg Gly Ser Glu Val Phe Leu Thr Lys Ile Glu Gln 
385                 390                 395                 400 


Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Val Ile Pro 
                405                 410                 415     


His Gln Ile His Leu Thr Glu Leu Arg Ala Ile Ile Ala Asn Gln Lys 
            420                 425                 430         


Lys His Tyr Pro Phe Leu Lys Glu Glu Gln Glu Lys Leu Glu Ser Leu 
        435                 440                 445             


Leu Thr Phe Lys Ile Pro Tyr Tyr Val Gly Pro Leu Ala Lys Lys Gln 
    450                 455                 460                 


Glu Asn Ser Pro Phe Ala Trp Leu Ile Arg Lys Ser Glu Glu Lys Ile 
465                 470                 475                 480 


Lys Pro Trp Asn Leu Pro Glu Ile Val Asp Met Glu Gly Ser Ala Val 
                485                 490                 495     


Arg Phe Ile Glu Arg Met Asn Asn Thr Asp Met Tyr Ile Pro His Asn 
            500                 505                 510         


Lys Val Leu Pro Lys Asn Ser Leu Leu Tyr Gln Lys Phe Ser Ile Tyr 
        515                 520                 525             


Asn Glu Leu Thr Lys Val Arg Tyr Gln Asp Glu Arg Gly Gln Met Asn 
    530                 535                 540                 


Tyr Phe Ser Ser Ile Glu Lys Lys Glu Ile Phe His Glu Leu Phe Glu 
545                 550                 555                 560 


Lys Asn Arg Lys Val Thr Lys Lys Asp Leu Gln Glu Phe Leu Tyr Leu 
                565                 570                 575     


Lys Tyr Asp Ile Lys His Ala Glu Leu Ser Gly Ile Glu Lys Ala Phe 
            580                 585                 590         


Asn Ala Ser Tyr Thr Thr Tyr His Asp Phe Leu Thr Met Ser Glu Asn 
        595                 600                 605             


Lys Arg Glu Met Lys Gln Trp Leu Glu Asp Pro Glu Leu Ala Ser Met 
    610                 615                 620                 


Phe Glu Glu Ile Ile Lys Thr Leu Thr Val Phe Glu Asp Arg Glu Met 
625                 630                 635                 640 


Ile Lys Thr Arg Leu Ser His His Glu Ala Thr Leu Gly Lys His Ile 
                645                 650                 655     


Ile Lys Lys Leu Thr Lys Lys His Tyr Thr Gly Trp Gly Arg Leu Ser 
            660                 665                 670         


Lys Glu Leu Ile Gln Gly Ile Arg Asp Lys Gln Ser Asn Lys Thr Ile 
        675                 680                 685             


Leu Asp Tyr Leu Ile Asn Asp Asp Asp Phe Pro His His Arg Asn Arg 
    690                 695                 700                 


Asn Phe Met Gln Leu Ile Asn Asp Asp Ser Leu Ser Phe Lys Lys Glu 
705                 710                 715                 720 


Ile Lys Lys Ala Gln Met Ile Thr Asp Thr Glu Asn Leu Glu Glu Ile 
                725                 730                 735     


Val Lys Glu Leu Thr Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln 
            740                 745                 750         


Ser Leu Lys Ile Val Asp Glu Ile Val Gly Ile Met Gly Tyr Glu Pro 
        755                 760                 765             


Ala Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Gly Arg 
    770                 775                 780                 


Gly Leu Lys Ser Ser Arg Pro Arg Leu Lys Ala Leu Glu Glu Ser Leu 
785                 790                 795                 800 


Lys Asp Phe Gly Ser Gln Leu Leu Lys Glu Tyr Pro Thr Asp Asn Ser 
                805                 810                 815     


Ser Leu Gln Lys Asp Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg 
            820                 825                 830         


Asp Met Tyr Thr Gly Ala Pro Leu Asp Ile His Arg Leu Ser Asp Tyr 
        835                 840                 845             


Asp Ile Asp His Ile Ile Pro Arg Ser Phe Thr Thr Asp Asn Ser Ile 
    850                 855                 860                 


Asp Asn Lys Val Leu Val Ser Ser Lys Glu Asn Arg Leu Lys Lys Asp 
865                 870                 875                 880 


Asp Val Pro Ser Glu Lys Val Val Lys Lys Met Arg Ser Phe Trp Tyr 
                885                 890                 895     


Asp Leu Tyr Ser Ser Lys Leu Ile Ser Lys Arg Lys Leu Asp Asn Leu 
            900                 905                 910         


Thr Lys Ile Lys Leu Thr Glu Glu Asp Lys Ala Gly Phe Ile Lys Arg 
        915                 920                 925             


Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gly Ile Leu 
    930                 935                 940                 


His His Arg Phe Asn Lys Ala Glu Asp Thr Asn Glu Pro Ile Arg Lys 
945                 950                 955                 960 


Val Arg Ile Ile Thr Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Asn 
                965                 970                 975     


Arg Phe Gly Ile Tyr Lys Val Arg Glu Ile Asn Glu Tyr His His Ala 
            980                 985                 990         


His Asp Ala Tyr Leu Asn Gly Val  Val Ala Leu Ala Leu  Leu Lys Lys 
        995                 1000                 1005             


Tyr Pro  Gln Leu Ala Pro Glu  Phe Val Tyr Gly Glu  Tyr Leu Lys 
    1010                 1015                 1020             


Phe Asn  Ala His Lys Ala Asn  Lys Ala Thr Val Lys  Lys Glu Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Lys Phe  Phe Glu Ser Asp Thr  Pro Val Cys 
    1040                 1045                 1050             


Asp Glu  Asn Gly Glu Ile Phe  Trp Asp Lys Ser Lys  Ser Ile Ala 
    1055                 1060                 1065             


Gln Val  Lys Lys Val Ile Asn  His His His Met Asn  Ile Val Lys 
    1070                 1075                 1080             


Lys Thr  Glu Ile Gln Lys Gly  Gly Phe Ser Lys Glu  Thr Val Glu 
    1085                 1090                 1095             


Pro Lys  Lys Asp Ser Ser Lys  Leu Leu Pro Arg Lys  Asn Asn Trp 
    1100                 1105                 1110             


Asp Pro  Ala Lys Tyr Gly Gly  Leu Gly Ser Pro Asn  Val Ala Tyr 
    1115                 1120                 1125             


Thr Val  Ala Phe Thr Tyr Glu  Lys Gly Lys Ala Arg  Lys Arg Thr 
    1130                 1135                 1140             


Asn Ala  Leu Glu Gly Ile Thr  Ile Met Glu Arg Glu  Ala Phe Glu 
    1145                 1150                 1155             


Gln Ser  Pro Val Leu Phe Leu  Lys Asn Lys Gly Tyr  Glu Gln Ala 
    1160                 1165                 1170             


Glu Ile  Glu Met Lys Leu Pro  Lys Tyr Ala Leu Phe  Glu Leu Glu 
    1175                 1180                 1185             


Asn Gly  Arg Lys Arg Met Val  Ala Ser Asn Lys Glu  Ala Gln Lys 
    1190                 1195                 1200             


Ala Asn  Ser Phe Leu Leu Pro  Glu His Leu Val Thr  Leu Leu Tyr 
    1205                 1210                 1215             


His Ala  Lys Gln Tyr Asp Glu  Ile Ser His Lys Glu  Ser Phe Asp 
    1220                 1225                 1230             


Tyr Val  Asn Glu His His Lys  Glu Phe Ser Glu Val  Phe Ala Arg 
    1235                 1240                 1245             


Val Leu  Glu Phe Ala Gly Lys  Tyr Thr Leu Ala Glu  Lys Asn Ile 
    1250                 1255                 1260             


Glu Lys  Leu Glu Lys Ile Tyr  Lys Glu Asn Gln Thr  Asp Asp Leu 
    1265                 1270                 1275             


Ala Lys  Leu Ala Ser Ser Phe  Val Asn Leu Met Gln  Phe Asn Ala 
    1280                 1285                 1290             


Met Gly  Ala Pro Ala Asp Phe  Lys Phe Phe Asp Val  Thr Ile Pro 
    1295                 1300                 1305             


Arg Lys  Arg Tyr Thr Ser Leu  Thr Glu Ile Trp Gln  Ser Thr Ile 
    1310                 1315                 1320             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Arg Met 
    1325                 1330                 1335             


Gly Lys  
    1340 


<210> 206
<211> 1340
<212> PRT
<213> Enterococcus faecium


<220>
<223> Enterococcus faecium TX1337RF

<400> 206
Met Lys Lys Glu Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Val Leu Thr Asp Asp Tyr Arg Leu Val Ser Lys Lys Met 
            20                  25                  30          


Lys Val Ala Gly Asn Thr Glu Lys Ser Ser Thr Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Glu Gly Gln Thr Ala Glu Ala Arg Arg Ser 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Leu Ala Arg Arg Arg Gln Arg Ile Leu 
65                  70                  75                  80  


Glu Leu Gln Lys Ile Phe Ala Pro Glu Ile Leu Lys Ile Asp Glu His 
                85                  90                  95      


Phe Phe Ala Arg Leu Asn Glu Ser Phe Leu Val Leu Asp Glu Lys Lys 
            100                 105                 110         


Gln Ser Arg His Pro Val Phe Ala Thr Ile Lys Gln Glu Lys Ser Tyr 
        115                 120                 125             


His Gln Thr Tyr Pro Thr Ile Tyr His Leu Arg Gln Ala Leu Ala Asp 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Ile Arg Leu Val Tyr Leu Ala Met Ala His 
145                 150                 155                 160 


Leu Leu Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Thr 
                165                 170                 175     


Glu Asn Ser Ser Val Thr Glu Thr Phe Arg Gln Phe Leu Ser Thr Tyr 
            180                 185                 190         


Asn Gln Gln Phe Ser Glu Ala Asp Asp Lys Gln Thr Glu Lys Leu Asp 
        195                 200                 205             


Glu Ala Val Asp Cys Ser Phe Val Phe Thr Glu Lys Met Ser Lys Thr 
    210                 215                 220                 


Lys Lys Ala Glu Thr Leu Leu Lys Tyr Phe Pro His Glu Lys Ser Asn 
225                 230                 235                 240 


Gly Tyr Leu Ser Gln Phe Ile Lys Leu Met Val Gly Asn Gln Gly Asn 
                245                 250                 255     


Phe Lys Asn Val Phe Gly Leu Glu Glu Glu Ala Lys Leu Gln Phe Ser 
            260                 265                 270         


Lys Glu Thr Tyr Glu Glu Asp Leu Glu Glu Leu Leu Glu Lys Ile Gly 
        275                 280                 285             


Asp Asp Tyr Ile Asp Leu Phe Val Gln Ala Lys Asn Val Tyr Asp Ala 
    290                 295                 300                 


Val Leu Leu Ser Glu Ile Leu Ser Asp Ser Thr Lys Asn Thr Arg Ala 
305                 310                 315                 320 


Lys Leu Ser Ala Gly Met Ile Arg Arg Tyr Asp Ala His Lys Glu Asp 
                325                 330                 335     


Leu Val Leu Leu Lys Arg Phe Val Lys Glu Asn Leu Pro Lys Lys Tyr 
            340                 345                 350         


Arg Ala Phe Phe Gly Asp Asn Ser Val Asn Gly Tyr Ala Gly Tyr Ile 
        355                 360                 365             


Glu Gly His Ala Thr Gln Glu Asp Phe Tyr Lys Phe Val Lys Lys Glu 
    370                 375                 380                 


Leu Thr Gly Ile Arg Gly Ser Glu Val Phe Leu Thr Lys Ile Glu Gln 
385                 390                 395                 400 


Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Val Ile Pro 
                405                 410                 415     


His Gln Ile His Leu Thr Glu Leu Arg Ala Ile Ile Ala Asn Gln Lys 
            420                 425                 430         


Lys His Tyr Pro Phe Leu Lys Glu Glu Gln Glu Lys Leu Glu Ser Leu 
        435                 440                 445             


Leu Thr Phe Lys Ile Pro Tyr Tyr Val Gly Pro Leu Ala Lys Lys Gln 
    450                 455                 460                 


Glu Asn Ser Pro Phe Ala Trp Leu Ile Arg Lys Ser Glu Glu Lys Ile 
465                 470                 475                 480 


Lys Pro Trp Asn Leu Pro Glu Ile Val Asp Met Glu Gly Ser Ala Val 
                485                 490                 495     


Arg Phe Ile Glu Arg Met Ile Asn Thr Asp Met Tyr Met Pro His Asn 
            500                 505                 510         


Lys Val Leu Pro Lys Asn Ser Leu Leu Tyr Gln Lys Phe Ser Ile Tyr 
        515                 520                 525             


Asn Glu Leu Thr Lys Val Arg Tyr Gln Asp Glu Arg Gly Gln Met Asn 
    530                 535                 540                 


Tyr Phe Ser Ser Ile Glu Lys Lys Glu Ile Phe His Glu Leu Phe Glu 
545                 550                 555                 560 


Lys Asn Arg Lys Val Thr Lys Lys Asp Leu Gln Glu Phe Leu Tyr Leu 
                565                 570                 575     


Lys Tyr Asp Ile Lys His Ala Glu Leu Ser Gly Ile Glu Lys Ala Phe 
            580                 585                 590         


Asn Ala Ser Tyr Thr Thr Tyr His Asp Phe Leu Thr Met Ser Glu Asn 
        595                 600                 605             


Lys Arg Glu Met Lys Gln Trp Leu Glu Asp Pro Glu Leu Ala Ser Met 
    610                 615                 620                 


Phe Glu Glu Ile Ile Lys Thr Leu Thr Val Phe Glu Asp Arg Glu Met 
625                 630                 635                 640 


Ile Lys Thr Arg Leu Ser His His Glu Ala Thr Leu Gly Lys His Ile 
                645                 650                 655     


Ile Lys Lys Leu Thr Lys Lys His Tyr Thr Gly Trp Gly Arg Leu Ser 
            660                 665                 670         


Lys Glu Leu Ile Gln Gly Ile Arg Asp Lys Gln Ser Asn Lys Thr Ile 
        675                 680                 685             


Leu Asp Tyr Leu Ile Asn Asp Asp Asp Phe Pro His His Arg Asn Arg 
    690                 695                 700                 


Asn Phe Met Gln Leu Ile Asn Asp Asp Ser Leu Ser Phe Lys Lys Glu 
705                 710                 715                 720 


Ile Lys Lys Ala Gln Met Ile Thr Asp Thr Glu Asn Leu Glu Glu Ile 
                725                 730                 735     


Val Lys Glu Leu Thr Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln 
            740                 745                 750         


Ser Leu Lys Ile Val Asp Glu Ile Val Gly Ile Met Gly Tyr Glu Pro 
        755                 760                 765             


Ala Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr Gly Arg 
    770                 775                 780                 


Gly Leu Lys Ser Ser Arg Pro Arg Leu Lys Ala Leu Glu Glu Ser Leu 
785                 790                 795                 800 


Lys Asp Phe Gly Ser Gln Leu Leu Lys Glu Tyr Pro Thr Asp Asn Ser 
                805                 810                 815     


Ser Leu Gln Lys Asp Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg 
            820                 825                 830         


Asp Met Tyr Thr Gly Ala Pro Leu Asp Ile His Arg Leu Ser Asp Tyr 
        835                 840                 845             


Asp Ile Asp His Ile Ile Pro Arg Ser Phe Thr Thr Asp Asn Ser Ile 
    850                 855                 860                 


Asp Asn Lys Val Leu Val Ser Ser Lys Glu Asn Arg Leu Lys Lys Asp 
865                 870                 875                 880 


Asp Val Pro Ser Glu Lys Val Val Lys Lys Met Arg Ser Phe Trp Tyr 
                885                 890                 895     


Asp Leu Tyr Ser Ser Lys Leu Ile Ser Lys Arg Lys Leu Asp Asn Leu 
            900                 905                 910         


Thr Lys Ile Lys Leu Thr Glu Glu Asp Lys Ala Gly Phe Ile Lys Arg 
        915                 920                 925             


Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gly Ile Leu 
    930                 935                 940                 


His His Arg Phe Asn Lys Ala Glu Asp Thr Asn Glu Pro Ile Arg Lys 
945                 950                 955                 960 


Val Arg Ile Ile Thr Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Asn 
                965                 970                 975     


Arg Phe Gly Ile Tyr Lys Val Arg Glu Ile Asn Glu Tyr His His Ala 
            980                 985                 990         


His Asp Ala Tyr Leu Asn Gly Val  Val Ala Leu Ala Leu  Leu Lys Lys 
        995                 1000                 1005             


Tyr Pro  Gln Leu Ala Pro Glu  Phe Val Tyr Gly Glu  Tyr Leu Lys 
    1010                 1015                 1020             


Phe Asn  Ala His Lys Ala Asn  Lys Ala Thr Val Lys  Lys Glu Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Lys Phe  Phe Glu Ser Asp Thr  Pro Val Cys 
    1040                 1045                 1050             


Asp Glu  Asn Gly Glu Ile Phe  Trp Asp Lys Ser Lys  Ser Ile Ala 
    1055                 1060                 1065             


Gln Val  Lys Lys Val Ile Asn  His His His Met Asn  Ile Val Lys 
    1070                 1075                 1080             


Lys Thr  Glu Ile Gln Lys Gly  Gly Phe Ser Lys Glu  Thr Val Glu 
    1085                 1090                 1095             


Pro Lys  Lys Asp Ser Ser Lys  Leu Leu Pro Arg Lys  Asn Asn Trp 
    1100                 1105                 1110             


Asp Pro  Ala Lys Tyr Gly Gly  Leu Gly Ser Pro Asn  Val Ala Tyr 
    1115                 1120                 1125             


Thr Val  Ala Phe Thr Tyr Glu  Lys Gly Lys Ala Arg  Lys Arg Thr 
    1130                 1135                 1140             


Asn Ala  Leu Glu Gly Ile Thr  Ile Met Glu Arg Glu  Ala Phe Glu 
    1145                 1150                 1155             


Gln Ser  Pro Val Leu Phe Leu  Lys Asn Lys Gly Tyr  Glu Gln Ala 
    1160                 1165                 1170             


Glu Ile  Glu Met Lys Leu Pro  Lys Tyr Ala Leu Phe  Glu Leu Glu 
    1175                 1180                 1185             


Asn Gly  Arg Lys Arg Met Val  Ala Ser Asn Lys Glu  Ala Gln Lys 
    1190                 1195                 1200             


Ala Asn  Ser Phe Leu Leu Pro  Glu His Leu Val Thr  Leu Leu Tyr 
    1205                 1210                 1215             


His Ala  Lys Gln Tyr Asp Glu  Ile Ser His Lys Glu  Ser Phe Asp 
    1220                 1225                 1230             


Tyr Val  Asn Glu His His Lys  Glu Phe Ser Glu Val  Phe Ala Arg 
    1235                 1240                 1245             


Val Leu  Glu Phe Ala Gly Lys  Tyr Thr Leu Ala Glu  Lys Asn Ile 
    1250                 1255                 1260             


Glu Lys  Leu Glu Lys Ile Tyr  Lys Glu Asn Gln Thr  Asp Asp Leu 
    1265                 1270                 1275             


Ala Lys  Leu Ala Ser Ser Phe  Val Asn Leu Met Gln  Phe Asn Ala 
    1280                 1285                 1290             


Met Gly  Ala Pro Ala Asp Phe  Lys Phe Phe Asp Val  Thr Ile Pro 
    1295                 1300                 1305             


Arg Lys  Arg Tyr Thr Ser Leu  Thr Glu Ile Trp Gln  Ser Thr Ile 
    1310                 1315                 1320             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Arg Met 
    1325                 1330                 1335             


Gly Lys  
    1340 


<210> 207
<211> 1336
<212> PRT
<213> Enterococcus hirae

<400> 207
Met Thr Lys Asp Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Leu Thr Asp Asp Tyr Gln Leu Met Lys Arg Lys Met 
            20                  25                  30          


Ser Val His Gly Asn Thr Glu Lys Lys Lys Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Ala Arg Leu Phe Asp Glu Gly Gln Thr Ala Glu Phe Arg Arg Thr 
    50                  55                  60                  


Lys Arg Thr Asn Arg Arg Arg Leu Ala Arg Arg Lys Tyr Arg Leu Ser 
65                  70                  75                  80  


Lys Leu Gln Asp Leu Phe Ala Glu Glu Leu Cys Lys Gln Asp Asp Cys 
                85                  90                  95      


Phe Phe Val Arg Leu Glu Glu Ser Phe Leu Val Pro Glu Glu Lys Gln 
            100                 105                 110         


Tyr Lys Pro Ala Ser Ile Phe Pro Thr Leu Glu Glu Glu Lys Glu Tyr 
        115                 120                 125             


Tyr Gln Lys Tyr Pro Thr Ile Tyr His Leu Arg Gln Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Glu Lys Glu Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Leu Leu Lys Tyr Arg Gly His Phe Leu Phe Glu Gly Asp Leu Asp Thr 
                165                 170                 175     


Glu Asn Thr Ser Ile Glu Glu Ser Phe Arg Val Phe Leu Glu Gln Tyr 
            180                 185                 190         


Ser Lys Gln Ser Asp Gln Pro Leu Ile Val His Gln Pro Val Leu Thr 
        195                 200                 205             


Ile Leu Thr Asp Lys Leu Ser Lys Thr Lys Lys Val Glu Glu Ile Leu 
    210                 215                 220                 


Lys Tyr Tyr Pro Thr Glu Lys Ile Asn Ser Phe Phe Ala Gln Cys Leu 
225                 230                 235                 240 


Lys Leu Ile Val Gly Asn Gln Ala Asn Phe Lys Arg Ile Phe Asp Leu 
                245                 250                 255     


Glu Ala Glu Val Lys Leu Gln Phe Ser Lys Glu Thr Tyr Glu Glu Asp 
            260                 265                 270         


Leu Glu Ser Leu Leu Glu Lys Ile Gly Asp Glu Tyr Leu Asp Ile Phe 
        275                 280                 285             


Leu Gln Ala Lys Lys Val His Asp Ala Ile Leu Leu Ser Glu Ile Ile 
    290                 295                 300                 


Ser Ser Thr Val Lys His Thr Lys Ala Lys Leu Ser Ser Gly Met Val 
305                 310                 315                 320 


Glu Arg Tyr Glu Arg His Lys Ala Asp Leu Ala Lys Phe Lys Gln Phe 
                325                 330                 335     


Val Lys Glu Asn Val Pro Gln Lys Ala Thr Val Phe Phe Lys Asp Thr 
            340                 345                 350         


Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Lys Gly Lys Thr Thr Gln Glu 
        355                 360                 365             


Glu Phe Tyr Lys Phe Val Lys Lys Glu Leu Ser Gly Val Val Gly Ser 
    370                 375                 380                 


Glu Pro Phe Leu Glu Lys Ile Asp Gln Glu Thr Phe Leu Leu Lys Gln 
385                 390                 395                 400 


Arg Thr Tyr Thr Asn Gly Val Ile Pro His Gln Val His Leu Ile Glu 
                405                 410                 415     


Leu Lys Ala Ile Ile Asp Gln Gln Lys Gln His Tyr Pro Phe Leu Glu 
            420                 425                 430         


Glu Ala Gly Pro Lys Ile Ile Ala Leu Phe Lys Phe Arg Ile Pro Tyr 
        435                 440                 445             


Tyr Val Gly Pro Leu Ala Lys Glu Gln Glu Ala Ser Ser Phe Ala Trp 
    450                 455                 460                 


Ile Glu Arg Lys Thr Ala Glu Lys Ile Asn Pro Trp Asn Phe Ser Glu 
465                 470                 475                 480 


Val Val Asp Ile Glu Lys Ser Ala Met Arg Phe Ile Gln Arg Met Thr 
                485                 490                 495     


Lys Gln Asp Thr Tyr Leu Pro Thr Glu Lys Val Leu Pro Lys Asn Ser 
            500                 505                 510         


Leu Leu Tyr Gln Lys Tyr Met Ile Phe Asn Glu Leu Thr Lys Val Ser 
        515                 520                 525             


Tyr Lys Asp Glu Arg Gly Val Lys Gln Tyr Phe Ser Gly Asp Glu Lys 
    530                 535                 540                 


Gln Gln Ile Phe Lys Gln Leu Phe Gln Lys Glu Arg Gly Lys Ile Thr 
545                 550                 555                 560 


Val Lys Lys Leu Gln Asn Phe Leu Tyr Thr His Tyr His Ile Glu Asn 
                565                 570                 575     


Ala Gln Ile Phe Gly Ile Glu Lys Ala Phe Asn Ala Ser Tyr Ser Thr 
            580                 585                 590         


Tyr His Asp Phe Met Lys Leu Ala Lys Thr Asn Gln Lys Ala Met Gln 
        595                 600                 605             


Glu Trp Leu Glu Gln Pro Glu Met Glu Pro Ile Phe Glu Asp Ile Val 
    610                 615                 620                 


Lys Ile Leu Thr Ile Phe Glu Asp Arg Gln Met Ile Lys His Gln Leu 
625                 630                 635                 640 


Ser Lys Tyr Gln Glu Val Phe Gly Glu Lys Leu Leu Lys Glu Phe Ala 
                645                 650                 655     


Arg Lys His Tyr Thr Gly Trp Gly Arg Phe Ser Ala Lys Leu Ile His 
            660                 665                 670         


Gly Ile Arg Asp Arg Lys Thr Asn Lys Thr Ile Leu Asp Tyr Leu Ile 
        675                 680                 685             


Asn Asp Asp Asp Val Pro Ala Asn Arg Asn Arg Asn Leu Met Gln Leu 
    690                 695                 700                 


Ile Asn Asp Glu His Leu Ser Phe Lys Glu Glu Ile Ala Lys Ala Thr 
705                 710                 715                 720 


Val Phe Ser Lys His Lys Ser Leu Val Asp Val Ile Gln Asp Leu Pro 
                725                 730                 735     


Gly Ser Pro Ala Ile Lys Lys Gly Ile Trp Gln Ser Leu Lys Ile Val 
            740                 745                 750         


Glu Glu Leu Ile Ala Ile Ile Gly Tyr Lys Pro Lys Asn Ile Val Ile 
        755                 760                 765             


Glu Met Ala Arg Glu Asn Gln Lys Thr His Arg Thr Ser Pro Arg Leu 
    770                 775                 780                 


Lys Ala Leu Glu Asn Gly Leu Lys Gln Ile Gly Ser Thr Leu Leu Lys 
785                 790                 795                 800 


Glu Gln Pro Thr Asp Asn Lys Ala Leu Gln Lys Glu Arg Leu Tyr Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Pro Leu Glu 
            820                 825                 830         


Ile Glu Asn Leu His Gln Tyr Glu Val Asp His Ile Ile Pro Arg Ser 
        835                 840                 845             


Phe Ile Val Asp Asn Ser Ile Asp Asn Lys Val Leu Val Ala Ser Lys 
    850                 855                 860                 


Gln Asn Gln Lys Lys Arg Asp Asp Val Pro Lys Lys Gln Ile Val Asn 
865                 870                 875                 880 


Glu Gln Arg Ile Phe Trp Asn Gln Leu Lys Glu Ala Lys Leu Ile Ser 
                885                 890                 895     


Pro Lys Lys Tyr Ala Tyr Leu Thr Lys Ile Glu Leu Thr Pro Glu Asp 
            900                 905                 910         


Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Asn Ile Leu His Gln Ser Phe Asn Gln Glu Glu Glu 
    930                 935                 940                 


Gly Thr Asp Cys Asp Gly Val Gln Ile Ile Thr Leu Lys Ala Thr Leu 
945                 950                 955                 960 


Thr Ser Gln Phe Arg Gln Thr Phe Gly Leu Tyr Lys Val Arg Glu Ile 
                965                 970                 975     


Asn Pro His His His Ala His Asp Ala Tyr Leu Asn Gly Phe Ile Ala 
            980                 985                 990         


Asn Val Leu Leu Lys Arg Tyr Pro  Lys Leu Ala Pro Glu  Phe Val Tyr 
        995                 1000                 1005             


Gly Lys  Tyr Val Lys Tyr Ser  Leu Ala Arg Glu Asn  Lys Ala Thr 
    1010                 1015                 1020             


Ala Lys  Lys Glu Phe Tyr Ser  Asn Ile Leu Lys Phe  Leu Glu Ser 
    1025                 1030                 1035             


Asp Glu  Pro Phe Cys Asp Glu  Asn Gly Glu Ile Tyr  Trp Glu Lys 
    1040                 1045                 1050             


Ser His  His Leu Pro Arg Ile  Lys Lys Val Leu Ser  Ser His Gln 
    1055                 1060                 1065             


Val Asn  Val Val Lys Lys Val  Glu Gln Gln Lys Gly  Gly Phe Tyr 
    1070                 1075                 1080             


Lys Glu  Thr Val Asn Ser Lys  Glu Lys Pro Asp Lys  Leu Ile Glu 
    1085                 1090                 1095             


Arg Lys  Asn Asn Trp Asp Val  Thr Lys Tyr Gly Gly  Phe Gly Ser 
    1100                 1105                 1110             


Pro Val  Ile Ala Tyr Ala Ile  Ala Phe Val Tyr Ala  Lys Gly Lys 
    1115                 1120                 1125             


Thr Gln  Lys Lys Thr Arg Ala  Ile Glu Gly Ile Thr  Ile Met Glu 
    1130                 1135                 1140             


Gln Ala  Ala Phe Glu Lys Asp  Pro Thr Thr Phe Leu  Lys Glu Lys 
    1145                 1150                 1155             


Gly Phe  Pro Gln Val Thr Glu  Phe Ile Lys Leu Pro  Lys Tyr Thr 
    1160                 1165                 1170             


Leu Phe  Glu Phe Asp Asn Gly  Arg Arg Arg Phe Leu  Ala Ser His 
    1175                 1180                 1185             


Lys Glu  Ser Gln Lys Gly Asn  Pro Phe Ile Leu Ser  Asp Gln Leu 
    1190                 1195                 1200             


Val Thr  Leu Leu Tyr His Ala  Gln His Tyr Asp Lys  Ile Thr Tyr 
    1205                 1210                 1215             


Gln Glu  Ser Phe Asp Tyr Val  Asn Thr His Leu Ser  Asp Phe Ser 
    1220                 1225                 1230             


Ala Ile  Leu Thr Glu Val Leu  Ala Phe Ala Glu Lys  Tyr Thr Leu 
    1235                 1240                 1245             


Ala Asp  Lys Asn Ile Glu Arg  Ile Gln Glu Leu Tyr  Glu Glu Asn 
    1250                 1255                 1260             


Lys Tyr  Gly Glu Thr Ser Met  Ile Ala Gln Ser Phe  Leu Gln Leu 
    1265                 1270                 1275             


Leu Gln  Phe Asn Ala Ile Gly  Ala Pro Ala Asp Phe  Lys Phe Phe 
    1280                 1285                 1290             


Gly Val  Thr Ile Pro Arg Lys  Arg Tyr Thr Ser Leu  Thr Glu Ile 
    1295                 1300                 1305             


Trp Asp  Ala Thr Ile Ile Tyr  Gln Ser Val Thr Gly  Leu Tyr Glu 
    1310                 1315                 1320             


Thr Arg  Ile Arg Met Gly Asp  Leu Trp Ala Gly Glu  Gln 
    1325                 1330                 1335     


<210> 208
<211> 1330
<212> PRT
<213> Enterococcus italicus


<220>
<223> Enterococcus italicus DSM 15952

<400> 208
Met Lys Asn Asp Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Tyr Ser Val Val Thr Asp Asp Tyr Lys Val Ile Ser Lys Lys Met 
            20                  25                  30          


Asn Val Phe Gly Asn Thr Glu Lys Lys Ser Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Glu Ser Gly Gln Thr Ala Gln Glu Ala Arg Met 
    50                  55                  60                  


Lys Arg Thr Ser Arg Arg Arg Ile Ala Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Gln Pro Glu Met Asn His Leu Asp Asn Asn 
                85                  90                  95      


Phe Phe Tyr Arg Leu Asn Glu Ser Phe Leu Val Ala Asp Asp Ala Lys 
            100                 105                 110         


Tyr Asp Lys His Pro Ile Phe Gly Thr Leu Asp Glu Glu Ile His Phe 
        115                 120                 125             


His Glu Gln Phe Pro Thr Ile Tyr His Leu Arg Lys Tyr Leu Ala Asp 
    130                 135                 140                 


Gly Asp Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Ile Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly Asn Phe Leu Ile Glu Gly Glu Leu Asn Thr 
                165                 170                 175     


Glu Asn Asn Ser Val Ile Glu Leu Ser Lys Val Phe Val Gln Leu Tyr 
            180                 185                 190         


Asn Gln Thr Leu Ser Glu Leu Glu Gly Phe Gln Phe Ile Asp Glu Ser 
        195                 200                 205             


Ile Asp Phe Ser Glu Val Leu Thr Gln Gln Leu Ser Lys Ser Glu Arg 
    210                 215                 220                 


Ala Asp Asn Val Leu Lys Leu Phe Pro Asp Glu Lys Gly Thr Gly Ile 
225                 230                 235                 240 


Phe Ala Gln Phe Ile Lys Leu Ile Val Gly Asn Gln Gly Asn Phe Lys 
                245                 250                 255     


Lys Val Phe Gln Leu Glu Glu Asp Gln Lys Leu Gln Leu Ser Thr Asp 
            260                 265                 270         


Asp Tyr Glu Glu Asn Ile Glu Asn Leu Leu Ala Ile Ile Gly Asp Glu 
        275                 280                 285             


Tyr Gly Asp Ile Phe Val Ala Ala Gln Asn Leu Tyr Gln Ala Ile Leu 
    290                 295                 300                 


Leu Ala Gly Ile Leu Thr Ser Thr Glu Lys Thr Arg Ala Lys Leu Ser 
305                 310                 315                 320 


Ala Ser Met Ile Gln Arg Tyr Glu Glu His Ala Lys Asp Leu Lys Leu 
                325                 330                 335     


Leu Lys Arg Phe Val Lys Glu His Ile Pro Asp Lys Tyr Ala Glu Ile 
            340                 345                 350         


Phe Asn Asp Ala Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Lys 
        355                 360                 365             


Thr Lys Glu Glu Glu Phe Tyr Lys Tyr Leu Lys Thr Thr Leu Val Gln 
    370                 375                 380                 


Lys Ser Gly Tyr Gln Tyr Phe Ile Glu Lys Ile Glu Gln Glu Asn Phe 
385                 390                 395                 400 


Leu Arg Lys Gln Arg Ile Tyr Asp Asn Gly Val Ile Pro His Gln Val 
                405                 410                 415     


His Ala Glu Glu Leu Arg Ala Ile Leu Arg Lys Gln Glu Lys Tyr Tyr 
            420                 425                 430         


Ser Phe Leu Lys Glu Asn His Glu Lys Ile Glu Gln Ile Phe Lys Val 
        435                 440                 445             


Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Lys His Asn Glu Gln Ser 
    450                 455                 460                 


Arg Phe Ala Trp Asn Ile Arg Lys Ser Asp Glu Pro Ile Arg Pro Trp 
465                 470                 475                 480 


Asn Met Asn Asp Val Val Asp Glu Asn Ala Ser Ala Val Ala Phe Ile 
                485                 490                 495     


Glu Arg Met Thr Ile Lys Asp Ile Tyr Leu Asn Glu Asn Val Leu Pro 
            500                 505                 510         


Arg His Ser Leu Ile Tyr Glu Lys Phe Thr Val Phe Asn Glu Leu Thr 
        515                 520                 525             


Lys Val Leu Tyr Ala Asp Asp Arg Gly Val Phe Gln Arg Phe Ser Ala 
    530                 535                 540                 


Glu Glu Lys Glu Asp Ile Phe Glu Lys Leu Phe Lys Ser Glu Arg Lys 
545                 550                 555                 560 


Val Thr Lys Lys Lys Leu Glu Asn Tyr Leu Arg Ile Glu Leu Ser Ile 
                565                 570                 575     


Ser Ser Pro Ser Val Lys Gly Ile Glu Glu Gln Phe Asn Ala Asn Phe 
            580                 585                 590         


Gly Thr Tyr Leu Asp Leu Lys Lys Phe Asp Glu Leu His Pro Tyr Leu 
        595                 600                 605             


Asp Asp Glu Lys Tyr Gln Asp Thr Leu Glu Glu Val Ile Lys Val Leu 
    610                 615                 620                 


Thr Val Phe Glu Asp Arg Ser Met Ile Gln Asn Gln Leu Glu Gln Leu 
625                 630                 635                 640 


Pro Leu Asn Leu Ser Thr Lys Thr Ile Lys Ala Leu Ser Arg Arg Lys 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Arg Leu Ile Asp Gly Ile His 
            660                 665                 670         


Asp Lys Asn Ser Gly Lys Thr Ile Leu Asp Tyr Leu Ile Glu Asp Glu 
        675                 680                 685             


Ser Asp Ser Tyr Ile Val Asn Arg Asn Phe Met Gln Leu Ile Asn Asp 
    690                 695                 700                 


Asp His Leu Ser Phe Lys Lys Ile Ile Glu Asp Ser Gln Pro Tyr Lys 
705                 710                 715                 720 


Glu Gln Gln Ser Ala Glu Glu Ile Val Ser Glu Leu Ser Gly Ser Pro 
                725                 730                 735     


Ala Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu 
            740                 745                 750         


Val Ala Ile Met Gly Tyr Lys Pro Lys Asn Ile Val Val Glu Met Ala 
        755                 760                 765             


Arg Glu Asn Gln Thr Thr Gly Arg Gly Lys Gln Asn Ser Lys Pro Arg 
    770                 775                 780                 


Leu Lys Gly Ile Glu Asn Gly Leu Lys Glu Phe Ser Asp Ser Val Leu 
785                 790                 795                 800 


Lys Gly Ser Ser Ile Asp Asn Lys Gln Leu Gln Asn Asp Arg Leu Tyr 
                805                 810                 815     


Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly His Glu Leu 
            820                 825                 830         


Asp Ile Asp His Leu Ser Thr Tyr Asp Ile Asp His Ile Ile Pro Gln 
        835                 840                 845             


Ser Phe Leu Thr Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Thr Ser 
    850                 855                 860                 


Lys Ser Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val 
865                 870                 875                 880 


Arg Lys Met Asp Arg Phe Trp Arg Lys Leu Leu Asn Ala Lys Leu Ile 
                885                 890                 895     


Ser Glu Arg Lys Tyr Thr Asn Leu Thr Lys Lys Glu Leu Thr Glu Ser 
            900                 905                 910         


Asp Lys Ala Gly Phe Leu Lys Arg Gln Leu Val Glu Thr Arg Gln Ile 
        915                 920                 925             


Thr Lys His Val Ala Thr Ile Leu Asp Ser Lys Phe Asn Glu Asp Ser 
    930                 935                 940                 


Asn Asn Arg Asp Val Gln Ile Ile Thr Leu Lys Ser Ala Leu Val Ser 
945                 950                 955                 960 


Glu Phe Arg Lys Thr Phe Asn Leu Tyr Lys Val Arg Glu Ile Asn Asp 
                965                 970                 975     


Leu His His Ala His Asp Ala Tyr Leu Asn Ala Val Val Ala Leu Ser 
            980                 985                 990         


Leu Leu Arg Val Tyr Pro Gln Leu  Lys Pro Glu Phe Val  Tyr Gly Glu 
        995                 1000                 1005             


Tyr Gly  Lys Asn Ser Ile His  Asp Gln Asn Lys Ala  Thr Ile Lys 
    1010                 1015                 1020             


Lys Gln  Phe Tyr Ser Asn Ile  Thr Arg Tyr Phe Ala  Ser Lys Asp 
    1025                 1030                 1035             


Tyr Ile  Ile Asn Asp Asp Gly  Glu Ile Leu Trp Asn  Lys Gln Glu 
    1040                 1045                 1050             


Thr Ile  Ala Gln Val Ile Lys  Thr Leu Gly Met His  Gln Val Asn 
    1055                 1060                 1065             


Val Val  Lys Lys Val Glu Ile  Gln Lys Gly Gly Phe  Ser Lys Glu 
    1070                 1075                 1080             


Ser Ile  Gln Pro Lys Gly Glu  Ser Gln Lys Leu Ile  Arg Arg Lys 
    1085                 1090                 1095             


Gln Gln  Trp Asn Thr Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Val 
    1100                 1105                 1110             


Val Ala  Tyr Ala Ile Leu Leu  Ser Phe Asp Lys Gly  Lys Arg Lys 
    1115                 1120                 1125             


Ala Arg  Ser Phe Lys Ile Val  Gly Ile Thr Ile Gln  Asp Arg Glu 
    1130                 1135                 1140             


Ser Phe  Glu Gly Asn Pro Ile  Leu Tyr Leu Ser Lys  Lys Asp Tyr 
    1145                 1150                 1155             


His Asn  Pro Lys Val Glu Ala  Ile Leu Pro Lys Tyr  Ser Leu Phe 
    1160                 1165                 1170             


Glu Phe  Glu Asn Gly Arg Arg  Arg Met Val Ala Ser  Ala Ser Glu 
    1175                 1180                 1185             


Thr Gln  Lys Gly Asn Gln Leu  Ile Ile Pro Gly His  Leu Met Glu 
    1190                 1195                 1200             


Leu Leu  Tyr His Ser Lys Lys  Ile Ile Asn Gly Lys  Asn Ser Asp 
    1205                 1210                 1215             


Ser Val  Ser Tyr Ile Gln Asn  Asn Lys Glu Lys Phe  Arg Glu Ile 
    1220                 1225                 1230             


Phe Glu  Tyr Ile Val Asp Phe  Ser Ser Lys Tyr Ile  Ser Ala Asp 
    1235                 1240                 1245             


Ala Asn  Leu Asn Lys Ile Glu  Lys Ile Phe Glu Asn  Asn Phe His 
    1250                 1255                 1260             


Lys Ala  Ser Glu Gln Glu Ile  Ala Lys Ser Phe Ile  Asn Leu Leu 
    1265                 1270                 1275             


Thr Phe  Thr Ala Met Gly Ala  Pro Ala Asp Phe Glu  Phe Phe Gly 
    1280                 1285                 1290             


Glu Lys  Ile Pro Arg Lys Arg  Tyr Val Ser Ile Ser  Glu Ile Ile 
    1295                 1300                 1305             


Asp Ala  Val Phe Ile His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr 
    1310                 1315                 1320             


Arg Val  Arg Leu Thr Glu Val  
    1325                 1330 


<210> 209
<211> 1096
<212> PRT
<213> Eubacterium dolichum


<220>
<223> Eubacterium dolichum DSM 3991

<400> 209
Met Met Glu Val Phe Met Gly Arg Leu Val Leu Gly Leu Asp Ile Gly 
1               5                   10                  15      


Ile Thr Ser Val Gly Phe Gly Ile Ile Asp Leu Asp Glu Ser Glu Ile 
            20                  25                  30          


Val Asp Tyr Gly Val Arg Leu Phe Lys Glu Gly Thr Ala Ala Glu Asn 
        35                  40                  45              


Glu Thr Arg Arg Thr Lys Arg Gly Gly Arg Arg Leu Lys Arg Arg Arg 
    50                  55                  60                  


Val Thr Arg Arg Glu Asp Met Leu His Leu Leu Lys Gln Ala Gly Ile 
65                  70                  75                  80  


Ile Ser Thr Ser Phe His Pro Leu Asn Asn Pro Tyr Asp Val Arg Val 
                85                  90                  95      


Lys Gly Leu Asn Glu Arg Leu Asn Gly Glu Glu Leu Ala Thr Ala Leu 
            100                 105                 110         


Leu His Leu Cys Lys His Arg Gly Ser Ser Val Glu Thr Ile Glu Asp 
        115                 120                 125             


Asp Glu Ala Lys Ala Lys Glu Ala Gly Glu Thr Lys Lys Val Leu Ser 
    130                 135                 140                 


Met Asn Asp Gln Leu Leu Lys Ser Gly Lys Tyr Val Cys Glu Ile Gln 
145                 150                 155                 160 


Lys Glu Arg Leu Arg Thr Asn Gly His Ile Arg Gly His Glu Asn Asn 
                165                 170                 175     


Phe Lys Thr Arg Ala Tyr Val Asp Glu Ala Phe Gln Ile Leu Ser His 
            180                 185                 190         


Gln Asp Leu Ser Asn Glu Leu Lys Ser Ala Ile Ile Thr Ile Ile Ser 
        195                 200                 205             


Arg Lys Arg Met Tyr Tyr Asp Gly Pro Gly Gly Pro Leu Ser Pro Thr 
    210                 215                 220                 


Pro Tyr Gly Arg Tyr Thr Tyr Phe Gly Gln Lys Glu Pro Ile Asp Leu 
225                 230                 235                 240 


Ile Glu Lys Met Arg Gly Lys Cys Ser Leu Phe Pro Asn Glu Pro Arg 
                245                 250                 255     


Ala Pro Lys Leu Ala Tyr Ser Ala Glu Leu Phe Asn Leu Leu Asn Asp 
            260                 265                 270         


Leu Asn Asn Leu Ser Ile Glu Gly Glu Lys Leu Thr Ser Glu Gln Lys 
        275                 280                 285             


Ala Met Ile Leu Lys Ile Val His Glu Lys Gly Lys Ile Thr Pro Lys 
    290                 295                 300                 


Gln Leu Ala Lys Glu Val Gly Val Ser Leu Glu Gln Ile Arg Gly Phe 
305                 310                 315                 320 


Arg Ile Asp Thr Lys Gly Ser Pro Leu Leu Ser Glu Leu Thr Gly Tyr 
                325                 330                 335     


Lys Met Ile Arg Glu Val Leu Glu Lys Ser Asn Asp Glu His Leu Glu 
            340                 345                 350         


Asp His Val Phe Tyr Asp Glu Ile Ala Glu Ile Leu Thr Lys Thr Lys 
        355                 360                 365             


Asp Ile Glu Gly Arg Lys Lys Gln Ile Ser Glu Leu Ser Ser Asp Leu 
    370                 375                 380                 


Asn Glu Glu Ser Val His Gln Leu Ala Gly Leu Thr Lys Phe Thr Ala 
385                 390                 395                 400 


Tyr His Ser Leu Ser Phe Lys Ala Leu Arg Leu Ile Asn Glu Glu Met 
                405                 410                 415     


Leu Lys Thr Glu Leu Asn Gln Met Gln Ser Ile Thr Leu Phe Gly Leu 
            420                 425                 430         


Lys Gln Asn Asn Glu Leu Ser Val Lys Gly Met Lys Asn Ile Gln Ala 
        435                 440                 445             


Asp Asp Thr Ala Ile Leu Ser Pro Val Ala Lys Arg Ala Gln Arg Glu 
    450                 455                 460                 


Thr Phe Lys Val Val Asn Arg Leu Arg Glu Ile Tyr Gly Glu Phe Asp 
465                 470                 475                 480 


Ser Ile Val Val Glu Met Ala Arg Glu Lys Asn Ser Glu Glu Gln Arg 
                485                 490                 495     


Lys Ala Ile Arg Glu Arg Gln Lys Phe Phe Glu Met Arg Asn Lys Gln 
            500                 505                 510         


Val Ala Asp Ile Ile Gly Asp Asp Arg Lys Ile Asn Ala Lys Leu Arg 
        515                 520                 525             


Glu Lys Leu Val Leu Tyr Gln Glu Gln Asp Gly Lys Thr Ala Tyr Ser 
    530                 535                 540                 


Leu Glu Pro Ile Asp Leu Lys Leu Leu Ile Asp Asp Pro Asn Ala Tyr 
545                 550                 555                 560 


Glu Val Asp His Ile Ile Pro Ile Ser Ile Ser Leu Asp Asp Ser Ile 
                565                 570                 575     


Thr Asn Lys Val Leu Val Thr His Arg Glu Asn Gln Glu Lys Gly Asn 
            580                 585                 590         


Leu Thr Pro Ile Ser Ala Phe Val Lys Gly Arg Phe Thr Lys Gly Ser 
        595                 600                 605             


Leu Ala Gln Tyr Lys Ala Tyr Cys Leu Lys Leu Lys Glu Lys Asn Ile 
    610                 615                 620                 


Lys Thr Asn Lys Gly Tyr Arg Lys Lys Val Glu Gln Tyr Leu Leu Asn 
625                 630                 635                 640 


Glu Asn Asp Ile Tyr Lys Tyr Asp Ile Gln Lys Glu Phe Ile Asn Arg 
                645                 650                 655     


Asn Leu Val Asp Thr Ser Tyr Ala Ser Arg Val Val Leu Asn Thr Leu 
            660                 665                 670         


Thr Thr Tyr Phe Lys Gln Asn Glu Ile Pro Thr Lys Val Phe Thr Val 
        675                 680                 685             


Lys Gly Ser Leu Thr Asn Ala Phe Arg Arg Lys Ile Asn Leu Lys Lys 
    690                 695                 700                 


Asp Arg Asp Glu Asp Tyr Gly His His Ala Ile Asp Ala Leu Ile Ile 
705                 710                 715                 720 


Ala Ser Met Pro Lys Met Arg Leu Leu Ser Thr Ile Phe Ser Arg Tyr 
                725                 730                 735     


Lys Ile Glu Asp Ile Tyr Asp Glu Ser Thr Gly Glu Val Phe Ser Ser 
            740                 745                 750         


Gly Asp Asp Ser Met Tyr Tyr Asp Asp Arg Tyr Phe Ala Phe Ile Ala 
        755                 760                 765             


Ser Leu Lys Ala Ile Lys Val Arg Lys Phe Ser His Lys Ile Asp Thr 
    770                 775                 780                 


Lys Pro Asn Arg Ser Val Ala Asp Glu Thr Ile Tyr Ser Thr Arg Val 
785                 790                 795                 800 


Ile Asp Gly Lys Glu Lys Val Val Lys Lys Tyr Lys Asp Ile Tyr Asp 
                805                 810                 815     


Pro Lys Phe Thr Ala Leu Ala Glu Asp Ile Leu Asn Asn Ala Tyr Gln 
            820                 825                 830         


Glu Lys Tyr Leu Met Ala Leu His Asp Pro Gln Thr Phe Asp Gln Ile 
        835                 840                 845             


Val Lys Val Val Asn Tyr Tyr Phe Glu Glu Met Ser Lys Ser Glu Lys 
    850                 855                 860                 


Tyr Phe Thr Lys Asp Lys Lys Gly Arg Ile Lys Ile Ser Gly Met Asn 
865                 870                 875                 880 


Pro Leu Ser Leu Tyr Arg Asp Glu His Gly Met Leu Lys Lys Tyr Ser 
                885                 890                 895     


Lys Lys Gly Asp Gly Pro Ala Ile Thr Gln Met Lys Tyr Phe Asp Gly 
            900                 905                 910         


Val Leu Gly Asn His Ile Asp Ile Ser Ala His Tyr Gln Val Arg Asp 
        915                 920                 925             


Lys Lys Val Val Leu Gln Gln Ile Ser Pro Tyr Arg Thr Asp Phe Tyr 
    930                 935                 940                 


Tyr Ser Lys Glu Asn Gly Tyr Lys Phe Val Thr Ile Arg Tyr Lys Asp 
945                 950                 955                 960 


Val Arg Trp Ser Glu Lys Lys Lys Lys Tyr Val Ile Asp Gln Gln Asp 
                965                 970                 975     


Tyr Ala Met Lys Lys Ala Glu Lys Lys Ile Asp Asp Thr Tyr Glu Phe 
            980                 985                 990         


Gln Phe Ser Met His Arg Asp Glu  Leu Ile Gly Ile Thr  Lys Ala Glu 
        995                 1000                 1005             


Gly Glu  Ala Leu Ile Tyr Pro  Asp Glu Thr Trp His  Asn Phe Asn 
    1010                 1015                 1020             


Phe Phe  Phe His Ala Gly Glu  Thr Pro Glu Ile Leu  Lys Phe Thr 
    1025                 1030                 1035             


Ala Thr  Asn Asn Asp Lys Ser  Asn Lys Ile Glu Val  Lys Pro Ile 
    1040                 1045                 1050             


His Cys  Tyr Cys Lys Met Arg  Leu Met Pro Thr Ile  Ser Lys Lys 
    1055                 1060                 1065             


Ile Val  Arg Ile Asp Lys Tyr  Ala Thr Asp Val Val  Gly Asn Leu 
    1070                 1075                 1080             


Tyr Lys  Val Lys Lys Asn Thr  Leu Lys Phe Glu Phe  Asp 
    1085                 1090                 1095     


<210> 210
<211> 1114
<212> PRT
<213> Eubacterium rectale

<400> 210
Met Asn Tyr Thr Glu Lys Glu Lys Leu Phe Met Lys Tyr Ile Leu Ala 
1               5                   10                  15      


Leu Asp Ile Gly Ile Ala Ser Val Gly Trp Ala Ile Leu Asp Lys Glu 
            20                  25                  30          


Ser Glu Thr Val Ile Glu Ala Gly Ser Asn Ile Phe Pro Glu Ala Ser 
        35                  40                  45              


Ala Ala Asp Asn Gln Leu Arg Arg Asp Met Arg Gly Ala Lys Arg Asn 
    50                  55                  60                  


Asn Arg Arg Leu Lys Thr Arg Ile Asn Asp Phe Ile Lys Leu Trp Glu 
65                  70                  75                  80  


Asn Asn Asn Leu Ser Ile Pro Gln Phe Lys Ser Thr Glu Ile Val Gly 
                85                  90                  95      


Leu Lys Val Arg Ala Ile Thr Glu Glu Ile Thr Leu Asp Glu Leu Tyr 
            100                 105                 110         


Leu Ile Leu Tyr Ser Tyr Leu Lys His Arg Gly Ile Ser Tyr Leu Glu 
        115                 120                 125             


Asp Ala Leu Asp Asp Thr Val Ser Gly Ser Ser Ala Tyr Ala Asn Gly 
    130                 135                 140                 


Leu Lys Leu Asn Ala Lys Glu Leu Glu Thr His Tyr Pro Cys Glu Ile 
145                 150                 155                 160 


Gln Gln Glu Arg Leu Asn Thr Ile Gly Lys Tyr Arg Gly Gln Ser Gln 
                165                 170                 175     


Ile Ile Asn Glu Asn Gly Glu Val Leu Asp Leu Ser Asn Val Phe Thr 
            180                 185                 190         


Ile Gly Ala Tyr Arg Lys Glu Ile Gln Arg Val Phe Glu Ile Gln Lys 
        195                 200                 205             


Lys Tyr His Pro Glu Leu Thr Asp Glu Phe Cys Asp Gly Tyr Met Leu 
    210                 215                 220                 


Ile Phe Asn Arg Lys Arg Lys Tyr Tyr Glu Gly Pro Gly Asn Glu Lys 
225                 230                 235                 240 


Ser Arg Thr Asp Tyr Gly Arg Phe Thr Thr Lys Leu Asp Ala Asn Gly 
                245                 250                 255     


Asn Tyr Ile Thr Glu Asp Asn Ile Phe Glu Lys Leu Ile Gly Lys Cys 
            260                 265                 270         


Ser Val Tyr Pro Asp Glu Leu Arg Ala Ala Ala Ala Ser Tyr Thr Ala 
        275                 280                 285             


Gln Glu Tyr Asn Val Leu Asn Asp Leu Asn Asn Leu Thr Ile Asn Gly 
    290                 295                 300                 


Arg Lys Leu Glu Glu Asn Glu Lys His Glu Ile Val Glu Arg Ile Lys 
305                 310                 315                 320 


Ser Ser Asn Thr Ile Asn Met Arg Lys Ile Ile Ser Asp Cys Met Gly 
                325                 330                 335     


Glu Asn Ile Asp Asp Phe Ala Gly Ala Arg Ile Asp Lys Ser Gly Lys 
            340                 345                 350         


Glu Ile Phe His Lys Phe Glu Val Tyr Asn Lys Met Arg Lys Ala Leu 
        355                 360                 365             


Leu Glu Ile Gly Ile Asp Ile Ser Asn Tyr Ser Arg Glu Glu Leu Asp 
    370                 375                 380                 


Glu Ile Gly Tyr Ile Met Thr Ile Asn Thr Asp Lys Glu Ala Met Met 
385                 390                 395                 400 


Glu Ala Phe Gln Lys Ser Trp Ile Asp Leu Ser Asp Asp Val Lys Gln 
                405                 410                 415     


Cys Leu Ile Asn Met Arg Lys Thr Asn Gly Ala Leu Phe Asn Lys Trp 
            420                 425                 430         


Gln Ser Phe Ser Leu Lys Ile Met Asn Glu Leu Ile Pro Glu Met Tyr 
        435                 440                 445             


Ala Gln Pro Lys Glu Gln Met Thr Leu Leu Thr Glu Met Gly Val Thr 
    450                 455                 460                 


Lys Gly Thr Gln Glu Glu Phe Ala Gly Leu Lys Tyr Ile Pro Val Asp 
465                 470                 475                 480 


Val Val Ser Glu Asp Ile Phe Asn Pro Val Val Arg Arg Ser Val Arg 
                485                 490                 495     


Ile Ser Phe Lys Ile Leu Asn Ala Val Leu Lys Lys Tyr Lys Ala Leu 
            500                 505                 510         


Asp Thr Ile Val Ile Glu Met Pro Arg Asp Arg Asn Ser Glu Glu Gln 
        515                 520                 525             


Lys Lys Arg Ile Asn Asp Ser Gln Lys Leu Asn Glu Lys Glu Met Glu 
    530                 535                 540                 


Tyr Ile Glu Lys Lys Leu Ala Val Thr Tyr Gly Ile Lys Leu Ser Pro 
545                 550                 555                 560 


Ser Asp Phe Ser Ser Gln Lys Gln Leu Ser Leu Lys Leu Lys Leu Trp 
                565                 570                 575     


Asn Glu Gln Asp Gly Ile Cys Leu Tyr Ser Gly Lys Thr Ile Asp Pro 
            580                 585                 590         


Asn Asp Ile Ile Asn Asn Pro Gln Leu Phe Glu Ile Asp His Ile Ile 
        595                 600                 605             


Pro Arg Ser Ile Ser Phe Asp Asp Ala Arg Ser Asn Lys Val Leu Val 
    610                 615                 620                 


Tyr Arg Ser Glu Asn Gln Lys Lys Gly Asn Gln Thr Pro Tyr Tyr Tyr 
625                 630                 635                 640 


Leu Thr His Ser His Ser Glu Trp Ser Phe Glu Gln Tyr Lys Ala Thr 
                645                 650                 655     


Val Met Asn Leu Ser Lys Lys Lys Glu Tyr Ala Ile Ser Arg Lys Lys 
            660                 665                 670         


Ile Gln Asn Leu Leu Tyr Ser Glu Asp Ile Thr Lys Met Asp Val Leu 
        675                 680                 685             


Lys Gly Phe Ile Asn Arg Asn Ile Asn Asp Thr Ser Tyr Ala Ser Arg 
    690                 695                 700                 


Leu Val Leu Asn Thr Ile Gln Asn Phe Phe Met Ala Asn Glu Ala Asp 
705                 710                 715                 720 


Thr Lys Val Lys Val Ile Lys Gly Ser Tyr Thr His Gln Met Arg Cys 
                725                 730                 735     


Asn Leu Lys Leu Asp Lys Asn Arg Asp Glu Ser Tyr Ser His His Ala 
            740                 745                 750         


Val Asp Ala Met Leu Ile Gly Tyr Ser Glu Leu Gly Tyr Glu Ala Tyr 
        755                 760                 765             


His Lys Leu Gln Gly Glu Phe Ile Asp Phe Glu Thr Gly Glu Ile Leu 
    770                 775                 780                 


Arg Lys Asp Met Trp Asp Glu Asn Met Ser Asp Glu Val Tyr Ala Asp 
785                 790                 795                 800 


Tyr Leu Tyr Gly Lys Lys Trp Ala Asn Ile Arg Asn Glu Val Val Lys 
                805                 810                 815     


Ala Glu Lys Asn Val Lys Tyr Trp His Tyr Val Met Arg Lys Ser Asn 
            820                 825                 830         


Arg Gly Leu Cys Asn Gln Thr Ile Arg Gly Thr Arg Glu Tyr Asp Gly 
        835                 840                 845             


Lys Gln Tyr Lys Ile Asn Lys Leu Asp Ile Arg Thr Lys Glu Gly Ile 
    850                 855                 860                 


Lys Val Phe Ala Lys Leu Ala Phe Ser Lys Lys Asp Ser Asp Arg Glu 
865                 870                 875                 880 


Arg Leu Leu Val Tyr Leu Asn Asp Arg Arg Thr Phe Asp Asp Leu Cys 
                885                 890                 895     


Lys Ile Tyr Glu Asp Tyr Ser Asp Ala Ala Asn Pro Phe Val Gln Tyr 
            900                 905                 910         


Glu Lys Glu Thr Gly Asp Ile Ile Arg Lys Tyr Ser Lys Lys His Asn 
        915                 920                 925             


Gly Pro Arg Ile Asp Lys Leu Lys Tyr Lys Asp Gly Glu Val Gly Ala 
    930                 935                 940                 


Cys Ile Asp Ile Ser His Lys Tyr Gly Phe Glu Lys Gly Ser Lys Lys 
945                 950                 955                 960 


Val Ile Leu Glu Ser Leu Val Pro Tyr Arg Met Asp Val Tyr Tyr Lys 
                965                 970                 975     


Glu Glu Asn His Ser Tyr Tyr Leu Val Gly Val Lys Gln Ser Asp Ile 
            980                 985                 990         


Lys Phe Glu Lys Gly Arg Asn Val  Ile Asp Glu Glu Ala  Tyr Ala Arg 
        995                 1000                 1005             


Ile Leu  Val Asn Glu Lys Met  Ile Gln Pro Gly Gln  Ser Arg Ala 
    1010                 1015                 1020             


Asp Leu  Glu Asn Leu Gly Phe  Lys Phe Lys Leu Ser  Phe Tyr Lys 
    1025                 1030                 1035             


Asn Asp  Ile Ile Glu Tyr Glu  Lys Asp Gly Lys Ile  Tyr Thr Glu 
    1040                 1045                 1050             


Arg Leu  Val Ser Arg Thr Met  Pro Lys Gln Arg Asn  Tyr Ile Glu 
    1055                 1060                 1065             


Thr Lys  Pro Ile Asp Lys Ala  Lys Phe Glu Lys Gln  Asn Leu Val 
    1070                 1075                 1080             


Gly Leu  Gly Lys Thr Lys Phe  Ile Lys Lys Tyr Arg  Tyr Asp Ile 
    1085                 1090                 1095             


Leu Gly  Asn Lys Tyr Ser Cys  Ser Glu Glu Lys Phe  Thr Ser Phe 
    1100                 1105                 1110             


Cys 
    


<210> 211
<211> 1391
<212> PRT
<213> Eubacterium sp.


<220>
<223> Eubacterium sp. AS15

<400> 211
Met Glu Asn Lys Gln Tyr Tyr Ile Gly Leu Asp Val Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Thr Asp Thr Ser Tyr Asn Leu Leu Arg Ala Lys 
            20                  25                  30          


Gly Lys Asp Met Trp Gly Ala Arg Leu Phe Asp Glu Ala Lys Thr Ala 
        35                  40                  45              


Val Glu Arg Arg Thr Lys Arg Thr Ser Arg Arg Arg Ser Glu Arg Glu 
    50                  55                  60                  


Lys Ala Arg Lys Ala Met Leu Lys Glu Leu Phe Ala Asp Glu Ile Asn 
65                  70                  75                  80  


Lys Val Asp Pro Asn Phe Phe Ile Arg Leu Glu Glu Ser Lys Phe Phe 
                85                  90                  95      


Leu Asp Asp Arg Ser Glu Asn Asn Arg Gln Arg Tyr Thr Leu Phe Asn 
            100                 105                 110         


Asp Ala Lys Phe Thr Asp Lys Asp Tyr Tyr Glu Lys Tyr Lys Thr Ile 
        115                 120                 125             


Phe His Leu Arg Ser Ala Leu Ile Asn Ser Asp Glu Lys Phe Asp Val 
    130                 135                 140                 


Arg Leu Val Phe Leu Ala Ile Leu Asn Leu Phe Ser His Arg Gly His 
145                 150                 155                 160 


Phe Leu Asn Ala Ser Leu Lys Gly Asp Gly Glu Ile Gln Gly Val Asp 
                165                 170                 175     


Ile Phe Tyr Asn Asp Leu Tyr Glu Val Cys Glu Glu Phe Glu Ile Asp 
            180                 185                 190         


Leu Pro Gln Ile Ser Asn Ile Asp Asn Phe Glu Lys Ile Leu Ser Gln 
        195                 200                 205             


Lys Gly Lys Ser Arg Thr Lys Ile Leu Glu Glu Leu Ser Glu Glu Leu 
    210                 215                 220                 


Ser Ile Ser Lys Lys Glu Lys Ile Lys Tyr Ser Leu Leu Lys Leu Ile 
225                 230                 235                 240 


Cys Gly Met Lys Ile Lys Val Val Asp Ile Tyr Ala Asp Glu Asp Ile 
                245                 250                 255     


Gln Glu Asp Asp Lys Lys Lys Asp Leu Gly Phe Arg Glu Ser Asp Tyr 
            260                 265                 270         


Glu Lys Ser Ser Leu Glu Val Lys Glu Ile Ile Gly Asp Asp His Phe 
        275                 280                 285             


Glu Leu Ile Glu Arg Ala Lys Ala Val His Asp Ile Gly Leu Leu Ala 
    290                 295                 300                 


Asn Ile Ile Gly Asn Ser Lys Tyr Leu Cys Glu Ala Arg Val Glu Ala 
305                 310                 315                 320 


Tyr Asp Asn His His Lys Asp Leu Gln Lys Ile Lys Glu Leu Leu Lys 
                325                 330                 335     


Lys Tyr Asp Ile Lys Ala Tyr Thr Asp Met Phe Arg Lys Met Thr Asp 
            340                 345                 350         


Lys Asn Tyr Ser Ala Tyr Val Gly Ser Val Asn Ser Asn Ile Ala Lys 
        355                 360                 365             


Glu Arg Arg Ser Val Asp Asn Arg Lys Ile Glu Asp Leu Tyr Glu Tyr 
    370                 375                 380                 


Ile Lys Lys Ile Ala Leu Lys Asn Ile Ser Asp Asp Asn Glu Asp Lys 
385                 390                 395                 400 


Ile Glu Ile Leu Lys Lys Ile Glu Thr Gly Glu Phe Leu Lys Lys Gln 
                405                 410                 415     


Leu Thr Ala Ser Asn Gly Val Ile Pro Asn Gln Leu Gln Ser Arg Glu 
            420                 425                 430         


Leu Arg Ala Ile Leu Lys Lys Ala Glu Asn Tyr Leu Pro Phe Leu Lys 
        435                 440                 445             


Glu Lys Gly Glu Lys Asn Leu Thr Val Ser Glu Met Ile Ile Gln Leu 
    450                 455                 460                 


Phe Glu Phe Gln Ile Pro Tyr Tyr Val Gly Pro Leu Asp Lys Asn Pro 
465                 470                 475                 480 


Lys Lys Asp Lys Asn Ala Asn Ser Trp Ala Val Ile Pro Ser Gly Gly 
                485                 490                 495     


Arg Ile Leu Pro Trp Asn Phe Glu Asp Lys Val Asp Val Lys Gly Ser 
            500                 505                 510         


Arg Lys Glu Phe Ile Glu Lys Met Val Arg Lys Cys Thr Tyr Leu Ser 
        515                 520                 525             


Glu Glu His Thr Leu Pro Lys Gln Ser Leu Leu Tyr Glu Lys Phe Met 
    530                 535                 540                 


Val Leu Asn Glu Ile Asn Asn Ile Lys Ile Asp Gly Glu Lys Ile Ser 
545                 550                 555                 560 


Val Glu Ala Lys Gln Lys Ile Tyr Asn Asp Leu Phe Met Lys Gly Lys 
                565                 570                 575     


Lys Val Ser Gln Lys Ala Ile Lys Gln Glu Leu Ile Ser Leu Asn Ile 
            580                 585                 590         


Met Ser Lys Asp Ser Val Leu Ser Gly Ile Asp Thr Val Cys Asn Ala 
        595                 600                 605             


Tyr Leu Ser Ser Ile Ala Lys Phe Arg Gly Val Phe Asp Glu Asn Val 
    610                 615                 620                 


Asn Asn Gln Ser Thr Ile Asp Met Ile Glu Asp Ile Ile Phe Leu Lys 
625                 630                 635                 640 


Thr Val Tyr Ser Asp Glu Lys Arg Phe Val Lys Glu Glu Ile Val Glu 
                645                 650                 655     


Lys Tyr Gly Asp Glu Ile Asp Lys Asp Lys Ile Lys Arg Ile Leu Gly 
            660                 665                 670         


Phe Lys Phe Ser Asn Trp Gly Asn Ile Ser Lys Ser Phe Leu Glu Leu 
        675                 680                 685             


Glu Gly Ala Asp Val Gly Thr Gly Glu Ile Arg Ser Ile Ile Gln Ser 
    690                 695                 700                 


Leu Trp Glu Thr Asn Phe Asn Leu Met Glu Leu Leu Ser Ser Arg Phe 
705                 710                 715                 720 


Thr Tyr Met Asp Glu Leu Glu Lys Arg Val Lys Lys Leu Glu Lys Pro 
                725                 730                 735     


Leu Ser Glu Trp Thr Ile Glu Asp Leu Asp Asp Met Tyr Leu Ser Ser 
            740                 745                 750         


Pro Val Lys Arg Met Ile Trp Gln Ser Met Lys Ile Val Asp Glu Ile 
        755                 760                 765             


Gln Thr Val Ile Gly Tyr Ala Pro Lys Arg Ile Phe Val Glu Met Thr 
    770                 775                 780                 


Arg Ser Glu Gly Glu Lys Val Arg Thr Lys Ser Arg Lys Asp Arg Leu 
785                 790                 795                 800 


Lys Glu Leu Tyr Ser Ala Ile Lys Glu Asp Ser Lys Gln Trp Val Lys 
                805                 810                 815     


Glu Leu Asp Ala Lys Asp Glu Ser Tyr Phe Arg Ser Lys Lys Met Tyr 
            820                 825                 830         


Leu Tyr Tyr Leu Gln Lys Gly Arg Cys Met Tyr Ser Gly Glu Val Ile 
        835                 840                 845             


Glu Leu Asp Lys Leu Met Asp Asp Asn Leu Tyr Asp Ile Asp His Ile 
    850                 855                 860                 


Tyr Pro Arg Ser Phe Val Lys Asp Asp Ser Leu Asp Asn Leu Val Leu 
865                 870                 875                 880 


Val Lys Lys Glu Ile Asn Asn Arg Lys Gln Asn Asp Pro Ile Thr Pro 
                885                 890                 895     


Gln Ile Gln Ala Ser Cys Gln Gly Phe Trp Lys Val Leu His Glu Gln 
            900                 905                 910         


Gly Phe Ile Ser Asn Glu Lys Tyr Ser Arg Leu Thr Arg Lys Thr Gln 
        915                 920                 925             


Glu Phe Ser Asp Glu Glu Lys Leu Ser Phe Ile Asn Arg Gln Ile Val 
    930                 935                 940                 


Glu Thr Gly Gln Ala Thr Lys Cys Met Ala Gln Ile Leu Gln Lys Ser 
945                 950                 955                 960 


Met Gly Glu Asp Val Asp Val Val Phe Ser Lys Ala Arg Leu Val Ser 
                965                 970                 975     


Glu Phe Arg His Lys Phe Glu Leu Phe Lys Ser Arg Leu Ile Asn Asp 
            980                 985                 990         


Phe His His Ala Asn Asp Ala Tyr  Leu Asn Ile Val Val  Gly Asn Ser 
        995                 1000                 1005             


Tyr Phe  Val Lys Phe Thr Arg  Asn Pro Ala Asn Phe  Ile Lys Asp 
    1010                 1015                 1020             


Ala Arg  Lys Asn Pro Asp Asn  Pro Ala Tyr Lys Tyr  His Met Asp 
    1025                 1030                 1035             


Arg Phe  Phe Glu Arg Asp Val  Lys Ser Lys Ser Glu  Val Ala Trp 
    1040                 1045                 1050             


Ile Gly  Gln Ser Glu Gly Asn  Ala Gly Thr Ile Ala  Ile Val Lys 
    1055                 1060                 1065             


Lys Thr  Met Ser Lys Asn Ser  Pro Leu Ile Thr Lys  Lys Val Glu 
    1070                 1075                 1080             


Glu Gly  His Gly Ser Ile Thr  Lys Glu Thr Ile Val  Gly Val Lys 
    1085                 1090                 1095             


Glu Ile  Lys Phe Gly Arg Asn  Lys Val Glu Lys Ala  Asp Lys Thr 
    1100                 1105                 1110             


Pro Lys  Lys Ala Asn Leu Gln  Ala Tyr Arg Pro Ile  Lys Thr Ser 
    1115                 1120                 1125             


Asp Glu  Arg Leu Cys Asn Ile  Leu Arg Tyr Gly Gly  Arg Thr Ser 
    1130                 1135                 1140             


Ile Ser  Ile Ser Gly Tyr Cys  Leu Val Glu Tyr Val  Lys Lys Arg 
    1145                 1150                 1155             


Lys Thr  Ile Arg Ser Leu Glu  Ala Ile Pro Val Tyr  Leu Gly Arg 
    1160                 1165                 1170             


Lys Asp  Ser Leu Ser Glu Glu  Lys Leu Leu Asn Tyr  Phe Arg Tyr 
    1175                 1180                 1185             


Asn Leu  Asn Asp Gly Gly Lys  Asp Ser Val Ser Asp  Ile Arg Leu 
    1190                 1195                 1200             


Cys Leu  Pro Phe Ile Ser Thr  Asn Ser Leu Val Lys  Ile Asp Gly 
    1205                 1210                 1215             


Tyr Leu  Tyr Tyr Leu Gly Gly  Lys Asn Asp Asp Arg  Ile Gln Leu 
    1220                 1225                 1230             


Tyr Asn  Ala Tyr Gln Leu Lys  Met Lys Lys Glu Glu  Val Glu Tyr 
    1235                 1240                 1245             


Ile Arg  Lys Ile Glu Lys Ala  Val Ser Met Ser Lys  Phe Asp Glu 
    1250                 1255                 1260             


Ile Asp  Arg Glu Lys Asn Pro  Val Leu Thr Glu Glu  Lys Asn Ile 
    1265                 1270                 1275             


Glu Leu  Tyr Asn Lys Ile Gln  Asp Lys Phe Glu Asn  Thr Val Phe 
    1280                 1285                 1290             


Ser Lys  Arg Met Ser Leu Val  Lys Tyr Asn Lys Lys  Asp Leu Ser 
    1295                 1300                 1305             


Phe Gly  Asp Phe Leu Lys Asn  Lys Lys Ser Lys Phe  Glu Glu Ile 
    1310                 1315                 1320             


Asp Leu  Glu Lys Gln Cys Lys  Val Leu Tyr Asn Ile  Ile Phe Asn 
    1325                 1330                 1335             


Leu Ser  Asn Leu Lys Glu Val  Asp Leu Ser Asp Ile  Gly Gly Ser 
    1340                 1345                 1350             


Lys Ser  Thr Gly Lys Cys Arg  Cys Lys Lys Asn Ile  Thr Asn Tyr 
    1355                 1360                 1365             


Lys Glu  Phe Lys Leu Ile Gln  Gln Ser Ile Thr Gly  Leu Tyr Ser 
    1370                 1375                 1380             


Cys Glu  Lys Asp Leu Met Thr  Ile 
    1385                 1390     


<210> 212
<211> 1107
<212> PRT
<213> Eubacterium ventriosum


<220>
<223> Eubacterium ventriosum ATCC 27560

<400> 212
Met Gly Tyr Thr Val Gly Leu Asp Ile Gly Val Ala Ser Val Gly Val 
1               5                   10                  15      


Ala Val Leu Asp Glu Asn Asp Asn Ile Val Glu Ala Val Ser Asn Ile 
            20                  25                  30          


Phe Asp Glu Ala Asp Thr Ser Asn Asn Lys Val Arg Arg Thr Leu Arg 
        35                  40                  45              


Glu Gly Arg Arg Thr Lys Arg Arg Gln Lys Thr Arg Ile Glu Asp Phe 
    50                  55                  60                  


Lys Gln Leu Trp Glu Thr Ser Gly Tyr Ile Ile Pro His Lys Leu His 
65                  70                  75                  80  


Leu Asn Ile Ile Glu Leu Arg Asn Lys Gly Leu Thr Glu Leu Leu Ser 
                85                  90                  95      


Leu Asp Glu Leu Tyr Cys Val Leu Leu Ser Met Leu Lys His Arg Gly 
            100                 105                 110         


Ile Ser Tyr Leu Glu Asp Ala Asp Asp Gly Glu Lys Gly Asn Ala Tyr 
        115                 120                 125             


Lys Lys Gly Leu Ala Phe Asn Glu Lys Gln Leu Lys Glu Lys Met Pro 
    130                 135                 140                 


Cys Glu Ile Gln Leu Glu Arg Met Lys Lys Tyr Gly Lys Tyr His Gly 
145                 150                 155                 160 


Glu Phe Ile Ile Glu Ile Asn Asp Glu Lys Glu Tyr Gln Ser Asn Val 
                165                 170                 175     


Phe Thr Thr Lys Ala Tyr Lys Lys Glu Leu Glu Lys Ile Phe Glu Thr 
            180                 185                 190         


Gln Arg Cys Asn Gly Asn Lys Ile Asn Thr Lys Phe Ile Lys Lys Tyr 
        195                 200                 205             


Met Glu Ile Tyr Glu Arg Lys Arg Glu Tyr Tyr Ile Gly Pro Gly Asn 
    210                 215                 220                 


Glu Lys Ser Arg Thr Asp Tyr Gly Ile Tyr Thr Thr Arg Thr Asp Glu 
225                 230                 235                 240 


Glu Gly Asn Phe Ile Asp Glu Lys Asn Ile Phe Gly Lys Leu Ile Gly 
                245                 250                 255     


Lys Cys Ser Val Tyr Pro Glu Glu Tyr Arg Ala Ser Ser Ala Ser Tyr 
            260                 265                 270         


Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Lys Ile 
        275                 280                 285             


Asn Asn Glu Lys Leu Thr Glu Phe Gln Lys Lys Glu Ile Val Glu Ile 
    290                 295                 300                 


Ile Lys Asp Ala Ser Ser Val Asn Met Arg Lys Ile Ile Lys Lys Val 
305                 310                 315                 320 


Ile Asp Glu Asp Ile Glu Gln Tyr Ser Gly Ala Arg Ile Asp Lys Lys 
                325                 330                 335     


Gly Lys Glu Ile Tyr His Thr Phe Glu Ile Tyr Arg Lys Leu Lys Lys 
            340                 345                 350         


Glu Leu Lys Thr Ile Asn Val Asp Ile Asp Ser Phe Thr Arg Glu Glu 
        355                 360                 365             


Leu Asp Lys Thr Met Asp Ile Leu Thr Leu Asn Thr Glu Arg Glu Ser 
    370                 375                 380                 


Ile Val Lys Ala Phe Asp Glu Gln Lys Phe Val Tyr Glu Glu Asn Leu 
385                 390                 395                 400 


Ile Lys Lys Leu Ile Glu Phe Arg Lys Asn Asn Gln Arg Leu Phe Ser 
                405                 410                 415     


Gly Trp His Ser Phe Ser Tyr Lys Ala Met Leu Gln Leu Ile Pro Val 
            420                 425                 430         


Met Tyr Lys Glu Pro Lys Glu Gln Met Gln Leu Leu Thr Glu Met Asn 
        435                 440                 445             


Val Phe Lys Ser Lys Lys Glu Lys Tyr Val Asn Tyr Lys Tyr Ile Pro 
    450                 455                 460                 


Glu Asn Glu Val Val Lys Glu Ile Tyr Asn Pro Val Val Val Lys Ser 
465                 470                 475                 480 


Ile Arg Thr Thr Val Lys Ile Leu Asn Ala Leu Ile Lys Lys Tyr Gly 
                485                 490                 495     


Tyr Pro Glu Ser Val Val Ile Glu Met Pro Arg Asp Lys Asn Ser Asp 
            500                 505                 510         


Asp Glu Lys Glu Lys Ile Asp Met Asn Gln Lys Lys Asn Gln Glu Glu 
        515                 520                 525             


Tyr Glu Lys Ile Leu Asn Lys Ile Tyr Asp Glu Lys Gly Ile Glu Ile 
    530                 535                 540                 


Thr Asn Lys Asp Tyr Lys Lys Gln Lys Lys Leu Val Leu Lys Leu Lys 
545                 550                 555                 560 


Leu Trp Asn Glu Gln Glu Gly Leu Cys Leu Tyr Ser Gly Lys Lys Ile 
                565                 570                 575     


Ala Ile Glu Asp Leu Leu Asn His Pro Glu Phe Phe Glu Ile Asp His 
            580                 585                 590         


Ile Ile Pro Lys Ser Ile Ser Leu Asp Asp Ser Arg Ser Asn Lys Val 
        595                 600                 605             


Leu Val Tyr Lys Thr Glu Asn Ser Ile Lys Glu Asn Asp Thr Pro Tyr 
    610                 615                 620                 


His Tyr Leu Thr Arg Ile Asn Gly Lys Trp Gly Phe Asp Glu Tyr Lys 
625                 630                 635                 640 


Ala Asn Val Leu Glu Leu Arg Arg Arg Gly Lys Ile Asp Asp Lys Lys 
                645                 650                 655     


Val Asn Asn Leu Leu Cys Met Glu Asp Ile Thr Lys Ile Asp Val Val 
            660                 665                 670         


Lys Gly Phe Ile Asn Arg Asn Leu Asn Asp Thr Arg Tyr Ala Ser Arg 
        675                 680                 685             


Val Val Leu Asn Glu Met Gln Ser Phe Phe Glu Ser Arg Lys Tyr Cys 
    690                 695                 700                 


Asn Thr Lys Val Lys Val Ile Arg Gly Ser Leu Thr Tyr Gln Met Arg 
705                 710                 715                 720 


Gln Asp Leu His Leu Lys Lys Asn Arg Glu Glu Ser Tyr Ser His His 
                725                 730                 735     


Ala Val Asp Ala Met Leu Ile Ala Phe Ser Gln Lys Gly Tyr Glu Ala 
            740                 745                 750         


Tyr Arg Lys Ile Gln Lys Asp Cys Tyr Asp Phe Glu Thr Gly Glu Ile 
        755                 760                 765             


Leu Asp Lys Glu Lys Trp Asn Lys Tyr Ile Asp Asp Asp Glu Phe Asp 
    770                 775                 780                 


Asp Ile Leu Tyr Lys Glu Arg Met Asn Glu Ile Arg Lys Lys Ile Ile 
785                 790                 795                 800 


Glu Ala Glu Glu Lys Val Lys Tyr Asn Tyr Lys Ile Asp Lys Lys Cys 
                805                 810                 815     


Asn Arg Gly Leu Cys Asn Gln Thr Ile Tyr Gly Thr Arg Glu Lys Asp 
            820                 825                 830         


Gly Lys Ile His Lys Ile Ser Ser Tyr Asn Ile Tyr Asp Asp Lys Glu 
        835                 840                 845             


Cys Asn Ser Leu Lys Lys Met Ile Asn Ser Gly Lys Gly Ser Asp Leu 
    850                 855                 860                 


Leu Met Tyr Asn Asn Asp Pro Lys Thr Tyr Arg Asp Met Leu Lys Ile 
865                 870                 875                 880 


Leu Glu Thr Tyr Ser Ser Glu Lys Asn Pro Phe Val Ala Tyr Asn Lys 
                885                 890                 895     


Glu Thr Gly Asp Tyr Phe Arg Lys Tyr Ser Lys Asn His Asn Gly Pro 
            900                 905                 910         


Lys Val Glu Lys Val Lys Tyr Tyr Ser Gly Gln Ile Asn Ser Cys Ile 
        915                 920                 925             


Asp Ile Ser His Lys Tyr Gly His Ala Lys Asn Ser Lys Lys Val Val 
    930                 935                 940                 


Leu Val Ser Leu Asn Pro Tyr Arg Thr Asp Val Tyr Tyr Asp Asn Asp 
945                 950                 955                 960 


Thr Gly Lys Tyr Tyr Leu Val Gly Val Lys Tyr Asn His Ile Lys Cys 
                965                 970                 975     


Val Gly Asn Lys Tyr Val Ile Asp Ser Glu Thr Tyr Asn Glu Leu Leu 
            980                 985                 990         


Arg Lys Glu Gly Val Leu Asn Ser  Asp Glu Asn Leu Glu  Asp Leu Asn 
        995                 1000                 1005             


Ser Lys  Asn Ile Thr Tyr Lys  Phe Ser Leu Tyr Lys  Asn Asp Ile 
    1010                 1015                 1020             


Ile Gln  Tyr Glu Lys Gly Gly  Glu Tyr Tyr Thr Glu  Arg Phe Leu 
    1025                 1030                 1035             


Ser Arg  Ile Lys Glu Gln Lys  Asn Leu Ile Glu Thr  Lys Pro Ile 
    1040                 1045                 1050             


Asn Lys  Pro Asn Phe Gln Arg  Lys Asn Lys Lys Gly  Glu Trp Glu 
    1055                 1060                 1065             


Asn Thr  Arg Asn Gln Ile Ala  Leu Ala Lys Thr Lys  Tyr Val Gly 
    1070                 1075                 1080             


Lys Leu  Val Thr Asp Val Leu  Gly Asn Cys Tyr Ile  Val Asn Met 
    1085                 1090                 1095             


Glu Lys  Phe Ser Leu Val Val  Asp Lys 
    1100                 1105         


<210> 213
<211> 1391
<212> PRT
<213> Eubacterium yurii


<220>
<223> Eubacterium yurii subsp. margaretiae ATCC 43715

<400> 213
Met Glu Asn Lys Gln Tyr Tyr Ile Gly Leu Asp Val Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Thr Asp Thr Ser Tyr Asn Leu Leu Arg Ala Lys 
            20                  25                  30          


Gly Lys Asp Met Trp Gly Ala Arg Leu Phe Glu Lys Ala Asn Thr Ala 
        35                  40                  45              


Ala Glu Arg Arg Thr Lys Arg Thr Ser Arg Arg Arg Ser Glu Arg Glu 
    50                  55                  60                  


Lys Ala Arg Lys Ala Met Leu Lys Glu Leu Phe Ala Asp Glu Ile Asn 
65                  70                  75                  80  


Arg Val Asp Pro Ser Phe Phe Ile Arg Leu Glu Glu Ser Lys Phe Phe 
                85                  90                  95      


Leu Asp Asp Arg Ser Glu Asn Asn Arg Gln Arg Tyr Thr Leu Phe Asn 
            100                 105                 110         


Asp Ala Thr Phe Thr Asp Lys Asp Tyr Tyr Glu Lys Tyr Lys Thr Ile 
        115                 120                 125             


Phe His Leu Arg Ser Ala Leu Ile Asn Ser Asp Glu Lys Phe Asp Val 
    130                 135                 140                 


Arg Leu Val Phe Leu Ala Ile Leu Asn Leu Phe Ser His Arg Gly His 
145                 150                 155                 160 


Phe Leu Asn Ala Ser Leu Lys Gly Asp Gly Asp Ile Gln Gly Met Asp 
                165                 170                 175     


Val Phe Tyr Asn Asp Leu Val Glu Ser Cys Glu Tyr Phe Glu Ile Glu 
            180                 185                 190         


Leu Pro Arg Ile Thr Asn Ile Asp Asn Phe Glu Lys Ile Leu Ser Gln 
        195                 200                 205             


Lys Gly Lys Ser Arg Thr Lys Ile Leu Glu Glu Leu Ser Glu Glu Leu 
    210                 215                 220                 


Ser Ile Ser Lys Lys Asp Lys Ser Lys Tyr Asn Leu Ile Lys Leu Ile 
225                 230                 235                 240 


Ser Gly Leu Glu Ala Ser Val Val Glu Leu Tyr Asn Ile Glu Asp Ile 
                245                 250                 255     


Gln Asp Glu Asn Lys Lys Ile Lys Ile Gly Phe Arg Glu Ser Asp Tyr 
            260                 265                 270         


Glu Glu Ser Ser Leu Lys Val Lys Glu Ile Ile Gly Asp Glu Tyr Phe 
        275                 280                 285             


Asp Leu Val Glu Arg Ala Lys Ser Val His Asp Met Gly Leu Leu Ser 
    290                 295                 300                 


Asn Ile Ile Gly Asn Ser Lys Tyr Leu Cys Glu Ala Arg Val Glu Ala 
305                 310                 315                 320 


Tyr Glu Asn His His Lys Asp Leu Leu Lys Ile Lys Glu Leu Leu Lys 
                325                 330                 335     


Lys Tyr Asp Lys Lys Ala Tyr Asn Asp Met Phe Arg Lys Met Thr Asp 
            340                 345                 350         


Lys Asn Tyr Ser Ala Tyr Val Gly Ser Val Asn Ser Asn Ile Ala Lys 
        355                 360                 365             


Glu Arg Arg Ser Val Asp Lys Arg Lys Ile Glu Asp Leu Tyr Lys Tyr 
    370                 375                 380                 


Ile Glu Asp Thr Ala Leu Lys Asn Ile Pro Asp Asp Asn Lys Asp Lys 
385                 390                 395                 400 


Ile Glu Ile Leu Glu Lys Ile Lys Leu Gly Glu Phe Leu Lys Lys Gln 
                405                 410                 415     


Leu Thr Ala Ser Asn Gly Val Ile Pro Asn Gln Leu Gln Ser Arg Glu 
            420                 425                 430         


Leu Arg Ala Ile Leu Lys Lys Ala Glu Asn Tyr Leu Pro Phe Leu Lys 
        435                 440                 445             


Glu Lys Gly Glu Lys Asn Leu Thr Val Ser Glu Met Ile Ile Gln Leu 
    450                 455                 460                 


Phe Glu Phe Gln Ile Pro Tyr Tyr Val Gly Pro Leu Asp Lys Asn Pro 
465                 470                 475                 480 


Lys Lys Asp Asn Lys Ala Asn Ser Trp Ala Lys Ile Lys Gln Gly Gly 
                485                 490                 495     


Arg Ile Leu Pro Trp Asn Phe Glu Asp Lys Val Asp Val Lys Gly Ser 
            500                 505                 510         


Arg Lys Glu Phe Ile Glu Lys Met Val Arg Lys Cys Thr Tyr Ile Ser 
        515                 520                 525             


Asp Glu His Thr Leu Pro Lys Gln Ser Leu Leu Tyr Glu Lys Phe Met 
    530                 535                 540                 


Val Leu Asn Glu Ile Asn Asn Ile Lys Ile Asp Gly Glu Lys Ile Ser 
545                 550                 555                 560 


Val Glu Ala Lys Gln Lys Ile Tyr Asn Asp Leu Phe Val Lys Gly Lys 
                565                 570                 575     


Lys Val Ser Gln Lys Asp Ile Lys Lys Glu Leu Ile Ser Leu Asn Ile 
            580                 585                 590         


Met Asp Lys Asp Ser Val Leu Ser Gly Thr Asp Thr Val Cys Asn Ala 
        595                 600                 605             


Tyr Leu Ser Ser Ile Gly Lys Phe Thr Gly Val Phe Lys Glu Glu Ile 
    610                 615                 620                 


Asn Lys Gln Ser Ile Val Asp Met Ile Glu Asp Ile Ile Phe Leu Lys 
625                 630                 635                 640 


Thr Val Tyr Gly Asp Glu Lys Arg Phe Val Lys Glu Glu Ile Val Glu 
                645                 650                 655     


Lys Tyr Gly Asp Glu Ile Asp Lys Asp Lys Ile Lys Arg Ile Leu Gly 
            660                 665                 670         


Phe Lys Phe Ser Asn Trp Gly Asn Leu Ser Lys Ser Phe Leu Glu Leu 
        675                 680                 685             


Glu Gly Ala Asp Val Gly Thr Gly Glu Val Arg Ser Ile Ile Gln Ser 
    690                 695                 700                 


Leu Trp Glu Thr Asn Phe Asn Leu Met Glu Leu Leu Ser Ser Arg Phe 
705                 710                 715                 720 


Thr Tyr Met Asp Glu Leu Glu Lys Arg Val Lys Lys Leu Glu Lys Pro 
                725                 730                 735     


Leu Ser Glu Trp Thr Ile Glu Asp Leu Asp Asp Met Tyr Leu Ser Ser 
            740                 745                 750         


Pro Val Lys Arg Met Ile Trp Gln Ser Met Lys Ile Val Asp Glu Ile 
        755                 760                 765             


Gln Thr Val Ile Gly Tyr Ala Pro Lys Arg Ile Phe Val Glu Met Thr 
    770                 775                 780                 


Arg Ser Glu Gly Glu Lys Val Arg Thr Lys Ser Arg Lys Asp Arg Leu 
785                 790                 795                 800 


Lys Glu Leu Tyr Asn Gly Ile Lys Glu Asp Ser Lys Gln Trp Val Lys 
                805                 810                 815     


Glu Leu Asp Ser Lys Asp Glu Ser Tyr Phe Arg Ser Lys Lys Met Tyr 
            820                 825                 830         


Leu Tyr Tyr Leu Gln Lys Gly Arg Cys Met Tyr Ser Gly Glu Val Ile 
        835                 840                 845             


Glu Leu Asp Lys Leu Met Asp Asp Asn Leu Tyr Asp Ile Asp His Ile 
    850                 855                 860                 


Tyr Pro Arg Ser Phe Val Lys Asp Asp Ser Leu Asp Asn Leu Val Leu 
865                 870                 875                 880 


Val Lys Lys Glu Ile Asn Asn Arg Lys Gln Asn Asp Pro Ile Thr Pro 
                885                 890                 895     


Gln Ile Gln Ala Ser Cys Gln Gly Phe Trp Lys Ile Leu His Asp Gln 
            900                 905                 910         


Gly Phe Met Ser Asn Glu Lys Tyr Ser Arg Leu Thr Arg Lys Thr Gln 
        915                 920                 925             


Glu Phe Ser Asp Glu Glu Lys Leu Ser Phe Ile Asn Arg Gln Ile Val 
    930                 935                 940                 


Glu Thr Gly Gln Ala Thr Lys Cys Met Ala Gln Ile Leu Gln Lys Ser 
945                 950                 955                 960 


Met Gly Glu Asp Val Asp Val Val Phe Ser Lys Ala Arg Leu Val Ser 
                965                 970                 975     


Glu Phe Arg His Lys Phe Glu Leu Phe Lys Ser Arg Leu Ile Asn Asp 
            980                 985                 990         


Phe His His Ala Asn Asp Ala Tyr  Leu Asn Ile Val Val  Gly Asn Ser 
        995                 1000                 1005             


Tyr Phe  Val Lys Phe Thr Arg  Asn Pro Ala Asn Phe  Ile Lys Asp 
    1010                 1015                 1020             


Ala Arg  Lys Asn Pro Asp Asn  Pro Val Tyr Lys Tyr  His Met Asp 
    1025                 1030                 1035             


Arg Phe  Phe Glu Arg Asp Val  Lys Ser Lys Ser Glu  Val Ala Trp 
    1040                 1045                 1050             


Ile Gly  Gln Ser Glu Gly Asn  Ser Gly Thr Ile Val  Ile Val Lys 
    1055                 1060                 1065             


Lys Thr  Met Ala Lys Asn Ser  Pro Leu Ile Thr Lys  Lys Val Glu 
    1070                 1075                 1080             


Glu Gly  His Gly Ser Ile Thr  Lys Glu Thr Ile Val  Gly Val Lys 
    1085                 1090                 1095             


Glu Ile  Lys Phe Gly Arg Asn  Lys Val Glu Lys Ala  Asp Lys Thr 
    1100                 1105                 1110             


Pro Lys  Lys Pro Asn Leu Gln  Ala Tyr Arg Pro Ile  Lys Thr Ser 
    1115                 1120                 1125             


Asp Glu  Arg Leu Cys Asn Ile  Leu Arg Tyr Gly Gly  Arg Thr Ser 
    1130                 1135                 1140             


Ile Ser  Ile Ser Gly Tyr Cys  Leu Val Glu Tyr Val  Lys Lys Arg 
    1145                 1150                 1155             


Lys Thr  Ile Arg Ser Leu Glu  Ala Ile Pro Val Tyr  Leu Gly Arg 
    1160                 1165                 1170             


Lys Asp  Ser Leu Ser Glu Glu  Lys Leu Leu Asn Tyr  Phe Arg Tyr 
    1175                 1180                 1185             


Asn Leu  Asn Asp Gly Gly Lys  Asp Ser Val Ser Asp  Ile Arg Leu 
    1190                 1195                 1200             


Cys Leu  Pro Phe Ile Ser Thr  Asn Ser Leu Val Lys  Ile Asp Gly 
    1205                 1210                 1215             


Tyr Leu  Tyr Tyr Leu Gly Gly  Lys Asn Asp Asp Arg  Ile Gln Leu 
    1220                 1225                 1230             


Tyr Asn  Ala Tyr Gln Leu Lys  Met Lys Lys Glu Glu  Val Glu Tyr 
    1235                 1240                 1245             


Ile Arg  Lys Ile Glu Lys Ala  Val Ser Met Ser Lys  Phe Asp Glu 
    1250                 1255                 1260             


Ile Asp  Arg Glu Lys Asn Pro  Val Leu Thr Glu Glu  Lys Asn Ile 
    1265                 1270                 1275             


Glu Leu  Tyr Asn Lys Ile Gln  Asp Lys Phe Glu Asn  Thr Val Phe 
    1280                 1285                 1290             


Ser Lys  Arg Met Ser Leu Val  Lys Tyr Asn Lys Lys  Asp Leu Ser 
    1295                 1300                 1305             


Phe Gly  Asp Phe Leu Lys Asn  Lys Lys Ser Lys Phe  Glu Glu Ile 
    1310                 1315                 1320             


Asp Leu  Glu Lys Gln Cys Lys  Val Leu Tyr Asn Ile  Ile Phe Asn 
    1325                 1330                 1335             


Leu Ser  Asn Leu Lys Glu Val  Asp Leu Ser Asp Ile  Gly Gly Ser 
    1340                 1345                 1350             


Lys Ser  Thr Gly Lys Cys Arg  Cys Lys Lys Asn Ile  Thr Asn Tyr 
    1355                 1360                 1365             


Lys Glu  Phe Lys Leu Ile Gln  Gln Ser Ile Thr Gly  Leu Tyr Ser 
    1370                 1375                 1380             


Cys Glu  Lys Asp Leu Met Thr  Ile 
    1385                 1390     


<210> 214
<211> 1142
<212> PRT
<213> Facklamia hominis


<220>
<223> Facklamia hominis CCUG 36813

<400> 214
Met Tyr Ser Val Gly Leu Asp Ile Gly Ile Ala Ser Cys Gly Tyr Ser 
1               5                   10                  15      


Ile Ile Asn Asp Val Asn Gly Asn Ile Val Glu Leu Gly Thr Leu Leu 
            20                  25                  30          


Phe Lys Ser Arg Asn Ser Asp Asn Asn Glu Glu Arg Arg Thr Asn Arg 
        35                  40                  45              


Gly Ser Arg Arg Leu Ile Asn Arg Arg Arg Thr Arg Leu Asp Asp Gly 
    50                  55                  60                  


Lys Lys Leu Leu Ala Glu Lys Gly Phe Lys Gln Asp Ser Lys Leu Lys 
65                  70                  75                  80  


His Val Cys Pro Tyr Glu Leu Arg Val Lys Gly Leu His Glu Lys Leu 
                85                  90                  95      


Thr Gln Gly Glu Ile Tyr Lys Val Val Leu His Ile Leu Lys Lys Arg 
            100                 105                 110         


Gly Ile Ser Tyr Leu Asp Glu Ser Asp Glu Asn Ser Ser Gly Ile Asp 
        115                 120                 125             


Gly Ala Ser Tyr Lys Asp Gln Val Asn Leu Asn Leu Asn Leu Gln Lys 
    130                 135                 140                 


Glu Leu Thr Pro Gly Gln Ile Gln Leu Lys Arg Leu Lys Glu Asn Gly 
145                 150                 155                 160 


Arg Ile Lys Ser Gly Val Thr Phe Glu Asn Gly Tyr Gln Leu Asn Val 
                165                 170                 175     


Phe Ser Val Ser Ala Tyr Ala Asn Glu Leu Asn Lys Ile Leu Thr Lys 
            180                 185                 190         


Gln Ser Glu Tyr Tyr Ser Glu Ile Asp Gln Ile Trp Ile Asp Arg Phe 
        195                 200                 205             


Thr Lys Asn Gly Tyr Arg Lys Glu Ala Gly Leu Val Tyr Arg Lys Arg 
    210                 215                 220                 


Pro Tyr Tyr Asp Gly Pro Gly Asn Glu Lys Asn Asn Ser Ile Tyr Gly 
225                 230                 235                 240 


Arg Trp Ala Asn Phe Lys Glu Asp Gly His Pro Lys Glu Asn Ile Phe 
                245                 250                 255     


Asp Gln Leu Ile Gly Leu Asp Ser Val Asp Ser Thr Gln Val Arg Ala 
            260                 265                 270         


Ser Ala Ser Thr Leu Thr Ala Gln Lys Tyr Asn Leu Leu Asn Asp Leu 
        275                 280                 285             


Asn Asn Leu Thr Ile Ile Glu Asp Asp Arg Lys Phe Thr Thr Asp Glu 
    290                 295                 300                 


Lys Val Ser Ile Ile Asn Tyr Leu Met Thr Gln Asp Ile Thr Arg Phe 
305                 310                 315                 320 


Gly Pro Lys Glu Leu Ala Lys Phe Tyr Gln Leu Glu Val Asp Gln Ile 
                325                 330                 335     


Arg Gly Trp Arg Ile Asp Asn Lys Gly Asn Pro Glu Ile His Ser Leu 
            340                 345                 350         


Lys Val Tyr Arg Asp Trp Lys Lys Ile Phe Asn Thr Ser Ser Ile Asp 
        355                 360                 365             


Leu Thr Ser Ile Gln Thr Trp Val Val Asp Glu Leu Ala Asn Val Ile 
    370                 375                 380                 


Thr Leu Asn Thr Glu Ile Pro Ser Thr Leu Ala Thr Leu Lys Ile Lys 
385                 390                 395                 400 


Ile Pro Asp Ile Asp Gln Gln Ile Leu Asn Phe Val Glu Asn Asn Phe 
                405                 410                 415     


Tyr Glu Leu Lys Lys Lys Thr Ser Lys Asn Ser Trp His Ser Phe Ser 
            420                 425                 430         


Leu Lys Thr Leu Asn Ile Leu Ile Pro Glu Leu Leu Asn Thr Ser Glu 
        435                 440                 445             


Glu Gln Asn Thr Ile Leu Glu Arg Leu Asn Leu Lys Phe Asp Leu Lys 
    450                 455                 460                 


Asn Lys Tyr Ala Glu Lys Asn Gln Ile Pro Val Lys Glu Leu Leu Glu 
465                 470                 475                 480 


Gln Ile Tyr Asn Pro Thr Val Thr Lys Ser Val His Gln Ser Ile Lys 
                485                 490                 495     


Leu Phe Asn Glu Ile Ile Glu Lys Tyr Gly Lys Asn Asn Ile Ser Tyr 
            500                 505                 510         


Val Thr Ile Glu Met Pro Arg Asp Lys Asn Asp Gln Asp Gln Lys Asp 
        515                 520                 525             


Thr Ile Lys Arg Ile Asn Lys Leu Asn Ser Glu Arg Lys Asn Asp Ser 
    530                 535                 540                 


Glu Lys Tyr Phe Leu Glu Arg Ser Gly Trp Asp Thr Ile Arg Phe Glu 
545                 550                 555                 560 


Ser Ala Leu Lys Lys Pro Arg Phe Ala Glu Lys Leu Leu Phe Tyr Tyr 
                565                 570                 575     


Glu Gln Lys Gly Lys Cys Ala Tyr Ser Gly Gln Asp Ile Leu Ala Glu 
            580                 585                 590         


Ser Leu Leu Asn Glu Ser Cys Glu Val Asp His Ile Ile Pro Leu Ser 
        595                 600                 605             


Ile Ser Phe Asp Asp Ser Ile His Asn Lys Val Leu Val Thr Ala Ser 
    610                 615                 620                 


Ser Asn Gln Glu Lys Gly Gln Arg Thr Pro Tyr Met Ala Phe Ile Asp 
625                 630                 635                 640 


Gly Ala Lys Leu Gly Gln Ser Trp Asp Asp Phe Val Ala Trp Val Asn 
                645                 650                 655     


Ser Cys Gly Phe His Arg Lys Lys Val Gln Asn Leu Leu Tyr Glu Glu 
            660                 665                 670         


Asn Ile Phe Asn Pro Asp Val Gln Arg Gly Phe Val Ser Arg Asn Leu 
        675                 680                 685             


Asn Asp Thr Arg Tyr Ala Ser Arg Ile Val Leu Asn Ala Ile Gln Ser 
    690                 695                 700                 


Phe Phe Tyr Lys Gln Lys Asp Leu Thr Lys Val Lys Val Val Asn Gly 
705                 710                 715                 720 


Ser Phe Thr His Thr Leu Arg Lys Lys Trp Gly Ser Ser Leu Asp Lys 
                725                 730                 735     


Asn Arg Asp Thr Tyr His His His Ala Val Asp Ala Thr Leu Cys Ala 
            740                 745                 750         


Val Thr Pro Phe Ile Asn Ile Val Lys Tyr Glu Phe Phe Glu Glu Asp 
        755                 760                 765             


Gly Ile Lys Tyr Met Val Asp Leu Thr Thr Gly Glu Lys Val Ala Tyr 
    770                 775                 780                 


Ser Asp Tyr Lys Lys Met Lys Phe Tyr Asp Lys Arg Ala Tyr Val Pro 
785                 790                 795                 800 


Ile Trp Asp Gly Phe Ile Lys Gln Leu Thr Pro Ala Asn Leu Tyr Pro 
                805                 810                 815     


Lys Ile Lys Phe Ser His Gln Val Asp Ser Lys Trp Asn Arg Lys Ile 
            820                 825                 830         


Ser Asp Ala Thr Ile Tyr Ser Thr Arg Lys Ile Val Glu Thr Lys Ile 
        835                 840                 845             


Asn Lys Lys Gly Val Ala Lys Glu Thr Val Lys Asp Ile Val Ile Asp 
    850                 855                 860                 


Lys Ile Lys Asp Ile Tyr Thr Pro Glu Gly Trp Arg Lys Phe Lys Glu 
865                 870                 875                 880 


Lys Gln Asp Lys Leu Leu Met Lys Asn Phe Asp Glu Lys Thr Tyr Asn 
                885                 890                 895     


Lys Leu Ile Lys Ile Ala Lys Glu Tyr Pro Glu Lys Lys Glu Val Gln 
            900                 905                 910         


Thr Ser Asn Gly Lys Val Ser Leu Val Glu Val Ser Pro Phe Lys Met 
        915                 920                 925             


Tyr Cys Glu Glu Gln Asn Val Pro Ala Ile Arg Lys Tyr Ser Lys Lys 
    930                 935                 940                 


Gly Asn Gly Pro Tyr Ile Arg Ser Leu Lys Phe Tyr Asp Lys Glu Leu 
945                 950                 955                 960 


Gly Lys His Ile Asn Ile Thr Lys Asp Ser Tyr Gly Asn Asp Ile Glu 
                965                 970                 975     


Arg Thr Ile Arg Asn Lys Lys Ile Ile Leu Lys Asn Gln Asn Ser Trp 
            980                 985                 990         


Arg Thr Asp Val Tyr Tyr Asn Ser  Val Asn Asn Cys Tyr  Glu Leu Leu 
        995                 1000                 1005             


Gly Ile  Lys Tyr Cys His Leu  Lys Phe Tyr Arg Gly  Lys Tyr Gly 
    1010                 1015                 1020             


Ile Pro  Lys Ser Ile Tyr Asp  Glu Leu Lys Lys Glu  Asp Glu Ile 
    1025                 1030                 1035             


Ser Ser  Glu Ser Val Phe Lys  Phe Ser Leu Tyr Arg  His Asp Arg 
    1040                 1045                 1050             


Val Arg  Phe Glu Lys Asp Gly  Glu Tyr Ile Glu Ala  Leu Phe Gly 
    1055                 1060                 1065             


Ser Lys  Asn Glu Ser Asn Lys  Asn Tyr Leu Glu Leu  Ser Pro Ile 
    1070                 1075                 1080             


Asp Lys  Asn Lys Trp Leu Ser  Lys Glu Asn Val Lys  Phe Phe Gly 
    1085                 1090                 1095             


Glu Val  Ala Ala Ser Gly Arg  Phe Ile Lys Gly Leu  Lys Pro Gly 
    1100                 1105                 1110             


Ile Lys  Val Ile Lys Gln Ser  Thr Asp Tyr Met Gly  His Val Tyr 
    1115                 1120                 1125             


Ala Ile  His Gln Glu Lys Leu  Lys Phe Val Leu Ser  Asp Ala 
    1130                 1135                 1140         


<210> 215
<211> 1512
<212> PRT
<213> Fibrobacter succinogenes

<400> 215
Met Lys Lys Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Val Val Asn Ala Asp Glu Ile Thr Arg Asp Asp Gly Ser Arg Tyr 
            20                  25                  30          


Leu Lys Pro Asn Gly Ile Ser Ala Ala Gly Ser Arg Ile Ile Pro Met 
        35                  40                  45              


Ser Ala Asp Ile Leu Gly Asp Phe Glu Lys Gly Asn Ser Ile Ser Gln 
    50                  55                  60                  


Thr Ala Glu Arg Thr Arg Met Arg Met Ala Arg Arg Leu His Glu Arg 
65                  70                  75                  80  


Ala Leu Leu Arg Arg Glu Arg Leu Leu Arg Val Leu Asn Leu Leu Asp 
                85                  90                  95      


Phe Leu Pro Lys His Phe Ala Asp Lys Ile Asp Arg Tyr Gly Lys Phe 
            100                 105                 110         


Thr Asp Asp Ser Glu Pro Lys Leu Ala Trp Arg Lys Asn Thr Glu Gly 
        115                 120                 125             


Lys Tyr Glu Phe Ile Phe Gln Asp Ala Phe Asn Glu Met Leu Ala Glu 
    130                 135                 140                 


Phe Lys Asp Lys Gln Pro Glu Ile Val Glu Glu Gly Lys Lys Ile Pro 
145                 150                 155                 160 


Tyr Asp Trp Thr Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Glu Lys Ala 
                165                 170                 175     


Leu Ser Lys Glu Glu Leu Ser Trp Ile Leu Leu Gln Phe Asn Gln Lys 
            180                 185                 190         


Arg Gly Tyr Tyr Gln Leu Arg Gly Glu Glu Glu Glu Ile Pro Gln Asp 
        195                 200                 205             


Lys Lys Ile Glu Tyr Leu Ala Gln Lys Val Val Lys Val Glu Ala Thr 
    210                 215                 220                 


Asp Gln Lys Lys Gly Asp Asp Val Trp Tyr Asn Val Tyr Leu Glu Asn 
225                 230                 235                 240 


Gly Met Ile Tyr Arg Arg Thr Ser Lys Ala Pro Leu Asp Trp Glu Gly 
                245                 250                 255     


Lys Val Lys Glu Phe Ile Val Thr Thr Glu Val Glu Asn Asp Gly Glu 
            260                 265                 270         


Thr Pro Lys Lys Asp Lys Glu Gly Asn Ile Lys Arg Ser Phe Arg Ala 
        275                 280                 285             


Pro Lys Glu Asp Asp Trp Thr Leu Leu Lys Lys Lys Thr Glu Ala Asp 
    290                 295                 300                 


Ile Glu Asn Ser His Lys Thr Val Gly Cys Tyr Ile Tyr Asp Ser Leu 
305                 310                 315                 320 


Leu Asn Asn Pro Lys Gln Lys Ile Ile Gly Lys Leu Val Arg Thr Val 
                325                 330                 335     


Glu Arg Lys Phe Tyr Lys Glu Glu Leu Thr Gln Ile Leu Lys Lys Gln 
            340                 345                 350         


Val Glu Leu Ile Pro Glu Leu Arg Asp Asp Asn Leu Tyr Lys Gln Cys 
        355                 360                 365             


Ile Glu Glu Leu Tyr Pro Ile Asn Glu Ala His Arg Asn Thr Ile Ala 
    370                 375                 380                 


Lys Thr Asp Phe Ala Asn Leu Phe Ile Asn Asp Ile Leu Phe Tyr Gln 
385                 390                 395                 400 


Arg Pro Leu Lys Ser Lys Lys Ser Gln Ile Asp Asn Cys Pro Tyr Glu 
                405                 410                 415     


Glu Arg Ile Phe Ile Asp Ser Lys Thr Gly Glu Lys Lys Lys Val Pro 
            420                 425                 430         


Val Lys Cys Ile Ala Lys Ser Asn Pro Leu Phe Gln Glu Phe Arg Leu 
        435                 440                 445             


Trp Gln Phe Ile Gln Asn Leu Arg Ile Tyr Gln Arg Glu Lys Glu Ile 
    450                 455                 460                 


Asp Gly Lys Leu Leu Thr Asp Ile Asp Ile Thr Ser Glu Cys Leu Lys 
465                 470                 475                 480 


Ser Glu Glu Asp Tyr Val Arg Leu Phe Asp Trp Leu Asn Asp Arg Glu 
                485                 490                 495     


Thr Ile Glu Gln Glu Asp Leu Leu Lys His Leu Phe Asn Thr Lys Lys 
            500                 505                 510         


Ser Lys Asn Lys Glu Asn Pro Tyr Arg Trp Asn Tyr Val Glu Asp Lys 
        515                 520                 525             


Val Tyr Pro Cys Asn Glu Thr Arg Ala Thr Ile Leu Lys Gly Phe Ser 
    530                 535                 540                 


Lys Cys Gly Ile Asn Ala Ser Val Leu Ser Pro Glu Leu Glu Met Ala 
545                 550                 555                 560 


Leu Trp His Ile Leu Tyr Ser Val Glu Asp Lys Lys Glu Ile Glu Thr 
                565                 570                 575     


Ala Leu Thr His Phe Ala Gln Lys Gln Gly Trp Asn Asp Asp Phe Ala 
            580                 585                 590         


Lys Val Phe Ser Lys Ala Lys Pro Phe Lys Lys Asp Tyr Gly Ser Tyr 
        595                 600                 605             


Ser Glu Lys Ala Ile Lys Lys Leu Leu Ser Leu Met Arg Met Gly Lys 
    610                 615                 620                 


Tyr Trp Asn Gln Asp Asn Ile Asp Lys Asn Thr Leu Asp Arg Ile Asp 
625                 630                 635                 640 


Lys Ile Ile Asn Gly Glu Tyr Asp Glu Lys Ile Ser Asn Arg Val Arg 
                645                 650                 655     


Asp Asn Ala Ile Asn Leu Lys Asp Ile Ser Asp Phe Arg Gly Leu Pro 
            660                 665                 670         


Val Trp Leu Ala Cys Tyr Ile Val Tyr Asp Arg His Ser Glu Ala Lys 
        675                 680                 685             


Asp Cys Thr Lys Trp Asn Ser Pro Glu Glu Ile Asp Ser Tyr Leu Lys 
    690                 695                 700                 


Lys Phe Lys Gln His Ser Leu Arg Asn Pro Ile Val Glu Gln Val Val 
705                 710                 715                 720 


Thr Glu Thr Leu Arg Thr Val Arg Asp Ile Trp Ile Gln Glu Glu Gln 
                725                 730                 735     


Ile Asp Glu Ile His Leu Glu Leu Gly Arg Asp Leu Lys Asn Pro Ala 
            740                 745                 750         


Asp Lys Arg Lys Lys Met Ser Glu Asn Ile Leu Lys Asn Glu Asn Thr 
        755                 760                 765             


Asn Leu Arg Ile Lys Ala Met Leu Met Glu Phe Met Asn Pro Ser Met 
    770                 775                 780                 


Gly Ile Glu Asn Val Arg Pro Tyr Ser Pro Ser Gln Gln Asp Ile Leu 
785                 790                 795                 800 


Arg Ile Tyr Glu Glu Asn Ala Leu Asp Asn Leu Thr Lys Asp Asp Lys 
                805                 810                 815     


Asp Phe Asp Phe Ile Ser Lys Ile Ser Lys Gln Ala Gln Pro Ser Lys 
            820                 825                 830         


Thr Asp Ile Ile Arg Tyr Lys Cys Trp Leu Glu Gln Lys Tyr Arg Ser 
        835                 840                 845             


Pro Tyr Thr Gly Lys Thr Ile Ser Leu Ser Lys Leu Phe Thr Pro Ala 
    850                 855                 860                 


Tyr Glu Ile Glu His Val Ile Pro Gln Ser Leu Tyr Phe Asp Asp Ser 
865                 870                 875                 880 


Phe Ser Asn Lys Val Ile Cys Glu Ala Glu Val Asn Lys Leu Lys Asp 
                885                 890                 895     


Arg Gln Leu Gly Tyr Lys Phe Ile Ala Glu His His Gly Glu Lys Val 
            900                 905                 910         


Gln Leu Ser Gln Gly Glu Val Val Glu Ile Leu Ser Val Asp Ala Tyr 
        915                 920                 925             


Glu Lys Phe Val Lys Glu Asn Tyr Ala Asn Asn Arg Ile Lys Met Lys 
    930                 935                 940                 


Lys Leu Leu Met Glu Ser Ile Pro Asp Glu Phe Ile Glu Arg Gln Leu 
945                 950                 955                 960 


Asn Asp Ser Arg Tyr Ile Ser Lys Val Val Lys Gly Leu Leu Ser Asn 
                965                 970                 975     


Ile Val Arg Glu Lys Ile Asp Asp Glu Asn Tyr Glu Pro Glu Ala Val 
            980                 985                 990         


Ser Lys Asn Leu Ile Ser Cys Asn  Gly Ala Ile Thr Asp  Arg Leu Lys 
        995                 1000                 1005             


Lys Asp  Trp Gly Met Asn Asp  Val Trp Asn Ser Ile  Ile Leu Pro 
    1010                 1015                 1020             


Arg Phe  Ile Arg Met Asn Gln  Ile Thr Gly Lys Asp  Cys Phe Thr 
    1025                 1030                 1035             


Thr Thr  Asn Ala Glu Gly His  Leu Ile Pro Gln Met  Pro Leu Glu 
    1040                 1045                 1050             


Leu Gln  Lys Gly Phe Asn Lys  Lys Arg Ile Asp His  Arg His His 
    1055                 1060                 1065             


Ala Met  Asp Ala Ile Val Ile  Ala Cys Thr Thr Arg  Asp His Val 
    1070                 1075                 1080             


Asn Leu  Leu Asn Asn Glu Ala  Ala His Ser Lys Phe  Asn Ala Thr 
    1085                 1090                 1095             


Arg Tyr  Gln Leu Gln Arg Lys  Leu Arg Arg Phe Glu  Lys Ala Val 
    1100                 1105                 1110             


Ile Asp  Gly Lys Glu Arg Glu  Val Ala Lys Glu Phe  Leu Lys Pro 
    1115                 1120                 1125             


Trp Asp  Ser Phe Ser Ser Asp  Ser Lys Asn Ile Leu  Glu Asn Ile 
    1130                 1135                 1140             


Ile Val  Ser Phe Lys Gln Asn  Gln Arg Val Ile Asn  Lys Thr Thr 
    1145                 1150                 1155             


Asn Ala  Phe Leu His Phe Asp  Glu Asn Gly Lys Lys  Thr Phe Ile 
    1160                 1165                 1170             


Lys Gln  Gly Lys Gly Asp Ser  Trp Ala Ile Arg Lys  Ser Met His 
    1175                 1180                 1185             


Lys Asp  Thr Val Phe Gly Glu  Ile Asn Leu Arg Lys  Val Arg Ser 
    1190                 1195                 1200             


Val Ser  Leu Asn Glu Ala Ile  Lys Val Pro Glu Arg  Val Leu Asn 
    1205                 1210                 1215             


Lys Lys  Ile Lys Glu Lys Ile  Leu Glu Leu Lys Asn  Asn Lys Ile 
    1220                 1225                 1230             


Asp Ala  Lys Asn Ile Lys Lys  Tyr Ile Glu Glu Asn  His Thr Gly 
    1235                 1240                 1245             


Gly Tyr  Gly Ile Asp Ser Ser  Lys Ile Asp Val Phe  Tyr Phe Thr 
    1250                 1255                 1260             


Lys Glu  Thr Lys Glu Arg Phe  Phe Ala Thr Arg Lys  Thr Leu Asp 
    1265                 1270                 1275             


Thr Ser  Phe Asn Gln Ala Lys  Ile Lys Asp Ser Ile  Ala Asp Ser 
    1280                 1285                 1290             


Gly Ile  Gln Lys Ile Leu Leu  Ala His Leu Lys Ser  Lys Asn Gly 
    1295                 1300                 1305             


Asp Ala  Glu Gln Ala Phe Ser  Pro Asp Gly Ile Asp  Glu Met Asn 
    1310                 1315                 1320             


Lys Asn  Ile Val Glu Leu Asn  Asn Gly Lys Phe His  Gln Pro Ile 
    1325                 1330                 1335             


Leu Lys  Val Arg Val Tyr Glu  Lys Ala Asp Lys Phe  Ala Val Gly 
    1340                 1345                 1350             


Gln Lys  Gly Asn Lys Lys Val  Lys Phe Val Glu Ala  Ala Lys Gly 
    1355                 1360                 1365             


Thr Asn  Leu Phe Phe Ala Ile  Phe Glu Lys Asp Gly  Lys Arg Ser 
    1370                 1375                 1380             


Tyr Leu  Thr Ile Pro Leu Asn  Val Met Ile Asp Cys  Gln Lys Gln 
    1385                 1390                 1395             


Tyr Gly  Asn Gln Trp Lys Asn  Asn Ile Glu Ala Tyr  Leu Lys Glu 
    1400                 1405                 1410             


Lys Glu  Leu Val Glu Lys Asp  Val Lys Leu Gln Phe  Ile Leu Ser 
    1415                 1420                 1425             


Pro Asn  Asp Leu Val Tyr Leu  Pro Thr Glu Gly Ser  Ile Asp Lys 
    1430                 1435                 1440             


Lys Arg  Ile Tyr Lys Val Val  Ser Phe Thr Asn Asn  Arg Leu Tyr 
    1445                 1450                 1455             


Ala Ile  Pro Tyr Ala Ile Ala  Lys Ser Ile Val Asp  Lys Asn Glu 
    1460                 1465                 1470             


Phe Thr  Gln Leu Asn Lys Ile  Glu Phe Thr Asp Asn  Lys Glu Ser 
    1475                 1480                 1485             


Ile Lys  Asp Ala Cys Val Pro  Val Ile Ile Asp Arg  Leu Gly Asn 
    1490                 1495                 1500             


Val Ile  Glu Phe Asn Gly Lys  Arg Leu 
    1505                 1510         


<210> 216
<211> 1365
<212> PRT
<213> Filifactor alocis

<400> 216
Met Thr Lys Glu Tyr Tyr Leu Gly Leu Asp Val Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Thr Asp Ser Gln Tyr Asn Leu Cys Lys Phe Lys Lys 
            20                  25                  30          


Lys Asp Met Trp Gly Ile Arg Leu Phe Glu Ser Ala Asn Thr Ala Lys 
        35                  40                  45              


Asp Arg Arg Leu Gln Arg Gly Asn Arg Arg Arg Leu Glu Arg Lys Lys 
    50                  55                  60                  


Gln Arg Ile Asp Leu Leu Gln Glu Ile Phe Ser Pro Glu Ile Cys Lys 
65                  70                  75                  80  


Ile Asp Pro Thr Phe Phe Ile Arg Leu Asn Glu Ser Arg Leu His Leu 
                85                  90                  95      


Glu Asp Lys Ser Asn Asp Phe Lys Tyr Pro Leu Phe Ile Glu Lys Asp 
            100                 105                 110         


Tyr Ser Asp Ile Glu Tyr Tyr Lys Glu Phe Pro Thr Ile Phe His Leu 
        115                 120                 125             


Arg Lys His Leu Ile Glu Ser Glu Glu Lys Gln Asp Ile Arg Leu Ile 
    130                 135                 140                 


Tyr Leu Ala Leu His Asn Ile Ile Lys Thr Arg Gly His Phe Leu Ile 
145                 150                 155                 160 


Asp Gly Asp Leu Gln Ser Ala Lys Gln Leu Arg Pro Ile Leu Asp Thr 
                165                 170                 175     


Phe Leu Leu Ser Leu Gln Glu Glu Gln Asn Leu Ser Val Ser Leu Ser 
            180                 185                 190         


Glu Asn Gln Lys Asp Glu Tyr Glu Glu Ile Leu Lys Asn Arg Ser Ile 
        195                 200                 205             


Ala Lys Ser Glu Lys Val Lys Lys Leu Lys Asn Leu Phe Glu Ile Ser 
    210                 215                 220                 


Asp Glu Leu Glu Lys Glu Glu Lys Lys Ala Gln Ser Ala Val Ile Glu 
225                 230                 235                 240 


Asn Phe Cys Lys Phe Ile Val Gly Asn Lys Gly Asp Val Cys Lys Phe 
                245                 250                 255     


Leu Arg Val Ser Lys Glu Glu Leu Glu Ile Asp Ser Phe Ser Phe Ser 
            260                 265                 270         


Glu Gly Lys Tyr Glu Asp Asp Ile Val Lys Asn Leu Glu Glu Lys Val 
        275                 280                 285             


Pro Glu Lys Val Tyr Leu Phe Glu Gln Met Lys Ala Met Tyr Asp Trp 
    290                 295                 300                 


Asn Ile Leu Val Asp Ile Leu Glu Thr Glu Glu Tyr Ile Ser Phe Ala 
305                 310                 315                 320 


Lys Val Lys Gln Tyr Glu Lys His Lys Thr Asn Leu Arg Leu Leu Arg 
                325                 330                 335     


Asp Ile Ile Leu Lys Tyr Cys Thr Lys Asp Glu Tyr Asn Arg Met Phe 
            340                 345                 350         


Asn Asp Glu Lys Glu Ala Gly Ser Tyr Thr Ala Tyr Val Gly Lys Leu 
        355                 360                 365             


Lys Lys Asn Asn Lys Lys Tyr Trp Ile Glu Lys Lys Arg Asn Pro Glu 
    370                 375                 380                 


Glu Phe Tyr Lys Ser Leu Gly Lys Leu Leu Asp Lys Ile Glu Pro Leu 
385                 390                 395                 400 


Lys Glu Asp Leu Glu Val Leu Thr Met Met Ile Glu Glu Cys Lys Asn 
                405                 410                 415     


His Thr Leu Leu Pro Ile Gln Lys Asn Lys Asp Asn Gly Val Ile Pro 
            420                 425                 430         


His Gln Val His Glu Val Glu Leu Lys Lys Ile Leu Glu Asn Ala Lys 
        435                 440                 445             


Lys Tyr Tyr Ser Phe Leu Thr Glu Thr Asp Lys Asp Gly Tyr Ser Val 
    450                 455                 460                 


Val Gln Lys Ile Glu Ser Ile Phe Arg Phe Arg Ile Pro Tyr Tyr Val 
465                 470                 475                 480 


Gly Pro Leu Ser Thr Arg His Gln Glu Lys Gly Ser Asn Val Trp Met 
                485                 490                 495     


Val Arg Lys Pro Gly Arg Glu Asp Arg Ile Tyr Pro Trp Asn Met Glu 
            500                 505                 510         


Glu Ile Ile Asp Phe Glu Lys Ser Asn Glu Asn Phe Ile Thr Arg Met 
        515                 520                 525             


Thr Asn Lys Cys Thr Tyr Leu Ile Gly Glu Asp Val Leu Pro Lys His 
    530                 535                 540                 


Ser Leu Leu Tyr Ser Lys Tyr Met Val Leu Asn Glu Leu Asn Asn Val 
545                 550                 555                 560 


Lys Val Arg Gly Lys Lys Leu Pro Thr Ser Leu Lys Gln Lys Val Phe 
                565                 570                 575     


Glu Asp Leu Phe Glu Asn Lys Ser Lys Val Thr Gly Lys Asn Leu Leu 
            580                 585                 590         


Glu Tyr Leu Gln Ile Gln Asp Lys Asp Ile Gln Ile Asp Asp Leu Ser 
        595                 600                 605             


Gly Phe Asp Lys Asp Phe Lys Thr Ser Leu Lys Ser Tyr Leu Asp Phe 
    610                 615                 620                 


Lys Lys Gln Ile Phe Gly Glu Glu Ile Glu Lys Glu Ser Ile Gln Asn 
625                 630                 635                 640 


Met Ile Glu Asp Ile Ile Lys Trp Ile Thr Ile Tyr Gly Asn Asp Lys 
                645                 650                 655     


Glu Met Leu Lys Arg Val Ile Arg Ala Asn Tyr Ser Asn Gln Leu Thr 
            660                 665                 670         


Glu Glu Gln Met Lys Lys Ile Thr Gly Phe Gln Tyr Ser Gly Trp Gly 
        675                 680                 685             


Asn Phe Ser Lys Met Phe Leu Lys Gly Ile Ser Gly Ser Asp Val Ser 
    690                 695                 700                 


Thr Gly Glu Thr Phe Asp Ile Ile Thr Ala Met Trp Glu Thr Asp Asn 
705                 710                 715                 720 


Asn Leu Met Gln Ile Leu Ser Lys Lys Phe Thr Phe Met Asp Asn Val 
                725                 730                 735     


Glu Asp Phe Asn Ser Gly Lys Val Gly Lys Ile Asp Lys Ile Thr Tyr 
            740                 745                 750         


Asp Ser Thr Val Lys Glu Met Phe Leu Ser Pro Glu Asn Lys Arg Ala 
        755                 760                 765             


Val Trp Gln Thr Ile Gln Val Ala Glu Glu Ile Lys Lys Val Met Gly 
    770                 775                 780                 


Cys Glu Pro Lys Lys Ile Phe Ile Glu Met Ala Arg Gly Gly Glu Lys 
785                 790                 795                 800 


Val Lys Lys Arg Thr Lys Ser Arg Lys Ala Gln Leu Leu Glu Leu Tyr 
                805                 810                 815     


Ala Ala Cys Glu Glu Asp Cys Arg Glu Leu Ile Lys Glu Ile Glu Asp 
            820                 825                 830         


Arg Asp Glu Arg Asp Phe Asn Ser Met Lys Leu Phe Leu Tyr Tyr Thr 
        835                 840                 845             


Gln Phe Gly Lys Cys Met Tyr Ser Gly Asp Asp Ile Asp Ile Asn Glu 
    850                 855                 860                 


Leu Ile Arg Gly Asn Ser Lys Trp Asp Arg Asp His Ile Tyr Pro Gln 
865                 870                 875                 880 


Ser Lys Ile Lys Asp Asp Ser Ile Asp Asn Leu Val Leu Val Asn Lys 
                885                 890                 895     


Thr Tyr Asn Ala Lys Lys Ser Asn Glu Leu Leu Ser Glu Asp Ile Gln 
            900                 905                 910         


Lys Lys Met His Ser Phe Trp Leu Ser Leu Leu Asn Lys Lys Leu Ile 
        915                 920                 925             


Thr Lys Ser Lys Tyr Asp Arg Leu Thr Arg Lys Gly Asp Phe Thr Asp 
    930                 935                 940                 


Glu Glu Leu Ser Gly Phe Ile Ala Arg Gln Leu Val Glu Thr Arg Gln 
945                 950                 955                 960 


Ser Thr Lys Ala Ile Ala Asp Ile Phe Lys Gln Ile Tyr Ser Ser Glu 
                965                 970                 975     


Val Val Tyr Val Lys Ser Ser Leu Val Ser Asp Phe Arg Lys Lys Pro 
            980                 985                 990         


Leu Asn Tyr Leu Lys Ser Arg Arg  Val Asn Asp Tyr His  His Ala Lys 
        995                 1000                 1005             


Asp Ala  Tyr Leu Asn Ile Val  Val Gly Asn Val Tyr  Asn Lys Lys 
    1010                 1015                 1020             


Phe Thr  Ser Asn Pro Ile Gln  Trp Met Lys Lys Asn  Arg Asp Thr 
    1025                 1030                 1035             


Asn Tyr  Ser Leu Asn Lys Val  Phe Glu His Asp Val  Val Ile Asn 
    1040                 1045                 1050             


Gly Glu  Val Ile Trp Glu Lys  Cys Thr Tyr His Glu  Asp Thr Asn 
    1055                 1060                 1065             


Thr Tyr  Asp Gly Gly Thr Leu  Asp Arg Ile Arg Lys  Ile Val Glu 
    1070                 1075                 1080             


Arg Asp  Asn Ile Leu Tyr Thr  Glu Tyr Ala Tyr Cys  Glu Lys Gly 
    1085                 1090                 1095             


Glu Leu  Phe Asn Ala Thr Ile  Gln Asn Lys Asn Gly  Asn Ser Thr 
    1100                 1105                 1110             


Val Ser  Leu Lys Lys Gly Leu  Asp Val Lys Lys Tyr  Gly Gly Tyr 
    1115                 1120                 1125             


Phe Ser  Ala Asn Thr Ser Tyr  Phe Ser Leu Ile Glu  Phe Glu Asp 
    1130                 1135                 1140             


Lys Lys  Gly Asp Arg Ala Arg  His Ile Ile Gly Val  Pro Ile Tyr 
    1145                 1150                 1155             


Ile Ala  Asn Met Leu Glu His  Ser Pro Ser Ala Phe  Leu Glu Tyr 
    1160                 1165                 1170             


Cys Glu  Gln Lys Gly Tyr Gln  Asn Val Arg Ile Leu  Val Glu Lys 
    1175                 1180                 1185             


Ile Lys  Lys Asn Ser Leu Leu  Ile Ile Asn Gly Tyr  Pro Leu Arg 
    1190                 1195                 1200             


Ile Arg  Gly Glu Asn Glu Val  Asp Thr Ser Phe Lys  Arg Ala Ile 
    1205                 1210                 1215             


Gln Leu  Lys Leu Asp Gln Lys  Asn Tyr Glu Leu Val  Arg Asn Ile 
    1220                 1225                 1230             


Glu Lys  Phe Leu Glu Lys Tyr  Val Glu Lys Lys Gly  Asn Tyr Pro 
    1235                 1240                 1245             


Ile Asp  Glu Asn Arg Asp His  Ile Thr His Glu Lys  Met Asn Gln 
    1250                 1255                 1260             


Leu Tyr  Glu Val Leu Leu Ser  Lys Met Lys Lys Phe  Asn Lys Lys 
    1265                 1270                 1275             


Gly Met  Ala Asp Pro Ser Asp  Arg Ile Glu Lys Ser  Lys Pro Lys 
    1280                 1285                 1290             


Phe Ile  Lys Leu Glu Asp Leu  Ile Asp Lys Ile Asn  Val Ile Asn 
    1295                 1300                 1305             


Lys Met  Leu Asn Leu Leu Arg  Cys Asp Asn Asp Thr  Lys Ala Asp 
    1310                 1315                 1320             


Leu Ser  Leu Ile Glu Leu Pro  Lys Asn Ala Gly Ser  Phe Val Val 
    1325                 1330                 1335             


Lys Lys  Asn Thr Ile Gly Lys  Ser Lys Ile Ile Leu  Val Asn Gln 
    1340                 1345                 1350             


Ser Val  Thr Gly Leu Tyr Glu  Asn Arg Arg Glu Leu  
    1355                 1360                 1365 


<210> 217
<211> 1347
<212> PRT
<213> Finegoldia magna


<220>
<223> Finegoldia magna ACS-171-V-Col3

<400> 217
Met Lys Ser Glu Lys Lys Tyr Tyr Ile Gly Leu Asp Val Gly Thr Asn 
1               5                   10                  15      


Ser Val Gly Trp Ala Val Thr Asp Glu Phe Tyr Asn Ile Leu Arg Ala 
            20                  25                  30          


Lys Gly Lys Asp Leu Trp Gly Val Arg Leu Phe Glu Lys Ala Lys Thr 
        35                  40                  45              


Ala Ala Asp Thr Arg Thr Phe Arg Ser Gly Arg Arg Arg Asn Asp Arg 
    50                  55                  60                  


Lys Gly Met Arg Leu Gln Ile Leu Arg Glu Ile Phe Glu Asp Glu Ile 
65                  70                  75                  80  


Lys Lys Val Asp Lys Asp Phe Tyr Asp Arg Leu Asp Glu Ser Lys Phe 
                85                  90                  95      


Trp Ala Glu Asp Lys Lys Val Ser Gly Lys Tyr Ser Leu Phe Asn Asp 
            100                 105                 110         


Lys Asn Phe Ser Asp Lys Gln Tyr Phe Glu Lys Phe Pro Thr Ile Phe 
        115                 120                 125             


His Leu Arg Lys Tyr Leu Met Glu Glu His Gly Lys Val Asp Ile Arg 
    130                 135                 140                 


Tyr Tyr Phe Leu Ala Ile Asn Gln Met Met Lys Arg Arg Gly His Phe 
145                 150                 155                 160 


Leu Ile Asp Gly Gln Ile Ser His Val Thr Asp Asp Lys Pro Leu Lys 
                165                 170                 175     


Glu Gln Leu Ile Leu Leu Ile Asn Asp Leu Leu Lys Ile Glu Leu Glu 
            180                 185                 190         


Glu Glu Leu Met Asp Ser Ile Phe Glu Ile Leu Ala Asp Val Asn Glu 
        195                 200                 205             


Lys Arg Thr Asp Lys Lys Asn Asn Leu Lys Glu Leu Ile Lys Gly Gln 
    210                 215                 220                 


Asp Phe Asn Lys Gln Glu Gly Asn Ile Leu Asn Ser Ile Phe Glu Ser 
225                 230                 235                 240 


Ile Val Thr Gly Lys Ala Lys Ile Lys Asn Ile Ile Ser Asp Glu Asp 
                245                 250                 255     


Ile Leu Glu Lys Ile Lys Glu Asp Asn Lys Glu Asp Phe Val Leu Thr 
            260                 265                 270         


Gly Asp Ser Tyr Glu Glu Asn Leu Gln Tyr Phe Glu Glu Val Leu Gln 
        275                 280                 285             


Glu Asn Ile Thr Leu Phe Asn Thr Leu Lys Ser Thr Tyr Asp Phe Val 
    290                 295                 300                 


Ile Leu Gln Ser Ile Leu Lys Gly Lys Ser Thr Leu Ser Asp Ala Gln 
305                 310                 315                 320 


Val Glu Arg Tyr Asp Glu His Lys Lys Asp Leu Glu Ile Leu Lys Lys 
                325                 330                 335     


Val Ile Lys Lys Tyr Asp Glu Asp Gly Lys Leu Phe Lys Gln Val Phe 
            340                 345                 350         


Lys Glu Asp Asn Gly Asn Gly Tyr Val Ser Tyr Ile Gly Tyr Tyr Leu 
        355                 360                 365             


Asn Lys Asn Lys Lys Ile Thr Ala Lys Lys Lys Ile Ser Asn Ile Glu 
    370                 375                 380                 


Phe Thr Lys Tyr Val Lys Gly Ile Leu Glu Lys Gln Cys Asp Cys Glu 
385                 390                 395                 400 


Asp Glu Ala Val Lys Tyr Leu Leu Gly Lys Ile Glu Gln Glu Asn Phe 
                405                 410                 415     


Leu Leu Lys Gln Ile Ser Ser Ile Asn Ser Val Ile Pro His Gln Ile 
            420                 425                 430         


His Leu Phe Glu Leu Asp Lys Ile Leu Glu Asn Leu Ala Lys Asn Tyr 
        435                 440                 445             


Pro Ser Phe Asn Asn Lys Lys Glu Glu Phe Thr Lys Ile Glu Lys Ile 
    450                 455                 460                 


Arg Lys Thr Phe Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Asn 
465                 470                 475                 480 


Asp Tyr His Lys Asn Asn Gly Gly Asn Ala Trp Ile Phe Arg Asn Lys 
                485                 490                 495     


Gly Glu Lys Ile Arg Pro Trp Asn Phe Glu Lys Ile Val Asp Leu His 
            500                 505                 510         


Lys Ser Glu Glu Glu Phe Ile Lys Arg Met Leu Asn Gln Cys Thr Tyr 
        515                 520                 525             


Leu Pro Glu Glu Thr Val Leu Pro Lys Ser Ser Ile Leu Tyr Ser Glu 
    530                 535                 540                 


Tyr Met Val Leu Asn Glu Leu Asn Asn Leu Arg Ile Lys Gly Lys Pro 
545                 550                 555                 560 


Leu Asp Thr Asp Val Lys Leu Lys Leu Ile Glu Glu Leu Phe Lys Lys 
                565                 570                 575     


Lys Thr Lys Val Thr Leu Lys Ser Ile Arg Asp Tyr Met Ile Arg Asn 
            580                 585                 590         


Asn Phe Ala Asp Lys Glu Asp Phe Asp Asn Ser Glu Lys Asn Leu Glu 
        595                 600                 605             


Ile Val Ser Asn Met Lys Ser Tyr Ile Asp Phe Asn Asn Ile Leu Gly 
    610                 615                 620                 


Asp Lys Phe Glu Leu Glu Met Val Glu Asp Leu Ile Glu Lys Ile Thr 
625                 630                 635                 640 


Ile His Thr Gly Asn Lys Thr Leu Leu Lys Lys Tyr Ile Glu Glu Thr 
                645                 650                 655     


Tyr Pro Asp Leu Ser Ser Ser Gln Ile Gln Lys Ile Ile Asn Leu Lys 
            660                 665                 670         


Tyr Lys Asp Trp Gly Arg Leu Ser Arg Lys Leu Leu Asp Gly Ile Lys 
        675                 680                 685             


Gly Arg Asn Lys Thr Asp Asp Val Asn Thr Val Ile Asn Phe Met Arg 
    690                 695                 700                 


Asn Ser Ser Asp Asn Leu Met Gln Ile Ile Glu Gly Lys Asn Tyr Ser 
705                 710                 715                 720 


Phe Asn Glu Tyr Ile Asp Asn Leu Arg Lys Lys Tyr Ile Pro Gln Glu 
                725                 730                 735     


Ile Ser Tyr Glu Val Val Glu Asn Leu Tyr Val Ser Pro Ser Val Lys 
            740                 745                 750         


Lys Met Ile Trp Gln Val Ile Arg Val Thr Glu Glu Ile Thr Lys Val 
        755                 760                 765             


Met Gly Tyr Asp Pro Asp Lys Ile Phe Ile Glu Met Ala Lys Ser Glu 
    770                 775                 780                 


Glu Glu Lys Lys Thr Thr Ile Ser Arg Lys Asn Lys Leu Leu Asp Leu 
785                 790                 795                 800 


Tyr Lys Ala Ile Lys Lys Asp Glu Arg Asp Ser Gln Tyr Glu Lys Leu 
                805                 810                 815     


Leu Thr Gly Leu Asn Lys Leu Asp Glu Ser Glu Leu Arg Ser Lys Lys 
            820                 825                 830         


Leu Tyr Leu Tyr Tyr Thr Gln Met Gly Arg Asp Met Tyr Thr Gly Glu 
        835                 840                 845             


Lys Ile Asp Leu Asp Lys Leu Phe Asp Ser Thr His Tyr Asp Lys Asp 
    850                 855                 860                 


His Ile Ile Pro Gln Ser Met Lys Lys Asp Asp Ser Ile Ile Asn Asn 
865                 870                 875                 880 


Leu Val Leu Val Asn Lys Asn Ala Asn Gln Thr Thr Lys Gly Asn Ile 
                885                 890                 895     


Tyr Pro Val Pro Ser Ser Ile Arg Asn Asn Pro Asp Ile Tyr Asn Tyr 
            900                 905                 910         


Trp Lys Tyr Leu Met Glu Lys Glu Phe Ile Ser Lys Glu Lys Tyr Asn 
        915                 920                 925             


Arg Leu Ile Arg Asn Thr Pro Leu Thr Asn Glu Glu Leu Gly Val Phe 
    930                 935                 940                 


Ile Asn Arg Gln Leu Val Glu Thr Arg Gln Ser Thr Lys Ala Ile Lys 
945                 950                 955                 960 


Glu Leu Phe Glu Lys Phe Tyr Gln Lys Ser Lys Ile Ile Pro Val Lys 
                965                 970                 975     


Ala Ser Leu Ala Ser Asp Leu Arg Lys Asp Met Asn Thr Leu Lys Ser 
            980                 985                 990         


Arg Glu Val Asn Asp Leu His His  Ala His Asp Ala Phe  Leu Asn Ile 
        995                 1000                 1005             


Val Ala  Gly Asp Val Trp Asn  Arg Glu Phe Thr Ser  Asn Pro Ile 
    1010                 1015                 1020             


Asn Tyr  Val Asn Glu Asn Arg  Glu Gly Asp Lys Val  Lys Tyr Ser 
    1025                 1030                 1035             


Leu Ser  Lys Tyr Phe Thr Arg  Pro Arg Lys Ser Lys  Gly Lys Val 
    1040                 1045                 1050             


Ile Trp  Thr Pro Glu Lys Gly  Arg Lys Leu Ile Val  Asp Thr Leu 
    1055                 1060                 1065             


Asn Lys  Pro Ser Val Leu Ile  Ser Asn Glu Ser His  Val Lys Lys 
    1070                 1075                 1080             


Gly Glu  Leu Phe Asn Ala Thr  Ile Ser Gly Lys Lys  Asp Tyr Lys 
    1085                 1090                 1095             


Lys Gly  Lys Ile Tyr Leu Pro  Leu Lys Lys Asp Asp  Arg Leu Lys 
    1100                 1105                 1110             


Asp Val  Ser Lys Tyr Gly Gly  Tyr Lys Ala Ile Asn  Gly Ala Phe 
    1115                 1120                 1125             


Phe Phe  Leu Val Glu His Thr  Lys Ser Lys Lys Arg  Ile Arg Ser 
    1130                 1135                 1140             


Ile Glu  Leu Phe Pro Leu His  Leu Leu Ser Lys Phe  Tyr Glu Asp 
    1145                 1150                 1155             


Lys Asn  Thr Val Leu Asp Tyr  Ala Ile Asn Val Leu  Gln Leu Gln 
    1160                 1165                 1170             


Asp Pro  Lys Ile Ile Ile Asp  Lys Ile Asn Tyr Arg  Thr Glu Ile 
    1175                 1180                 1185             


Ile Ile  Asp Asn Phe Ser Tyr  Leu Ile Ser Thr Lys  Ser Asn Asp 
    1190                 1195                 1200             


Gly Ser  Ile Thr Val Lys Pro  Asn Glu Gln Met Tyr  Trp Arg Val 
    1205                 1210                 1215             


Asp Glu  Ile Ser Asn Leu Lys  Lys Ile Glu Asn Lys  Tyr Lys Lys 
    1220                 1225                 1230             


Asp Ala  Ile Leu Thr Glu Glu  Asp Arg Lys Ile Met  Glu Ser Tyr 
    1235                 1240                 1245             


Ile Asp  Lys Ile Tyr Gln Gln  Phe Lys Ala Gly Lys  Tyr Lys Asn 
    1250                 1255                 1260             


Arg Arg  Thr Thr Asp Thr Ile  Ile Glu Lys Tyr Glu  Ile Ile Asp 
    1265                 1270                 1275             


Leu Asp  Thr Leu Asp Asn Lys  Gln Leu Tyr Gln Leu  Leu Val Ala 
    1280                 1285                 1290             


Phe Ile  Ser Leu Ser Tyr Lys  Thr Ser Asn Asn Ala  Val Asp Phe 
    1295                 1300                 1305             


Thr Val  Ile Gly Leu Gly Thr  Glu Cys Gly Lys Pro  Arg Ile Thr 
    1310                 1315                 1320             


Asn Leu  Pro Asp Asn Thr Tyr  Leu Val Tyr Lys Ser  Ile Thr Gly 
    1325                 1330                 1335             


Ile Tyr  Glu Lys Arg Ile Arg  Ile Lys 
    1340                 1345         


<210> 218
<211> 1348
<212> PRT
<213> Finegoldia magna

<400> 218
Met Lys Ser Glu Lys Lys Tyr Tyr Ile Gly Leu Asp Val Gly Thr Asn 
1               5                   10                  15      


Ser Val Gly Trp Ala Val Thr Asp Glu Phe Tyr Asn Ile Leu Arg Ala 
            20                  25                  30          


Lys Gly Lys Asp Leu Trp Gly Val Arg Leu Phe Glu Lys Ala Asp Thr 
        35                  40                  45              


Ala Ala Asn Thr Arg Ile Phe Arg Ser Gly Arg Arg Arg Asn Asp Arg 
    50                  55                  60                  


Lys Gly Met Arg Leu Gln Ile Leu Arg Glu Ile Phe Glu Asp Glu Ile 
65                  70                  75                  80  


Lys Lys Val Asp Lys Asp Phe Tyr Asp Arg Leu Asp Glu Ser Lys Phe 
                85                  90                  95      


Trp Ala Glu Asp Lys Lys Val Ser Gly Lys Tyr Ser Leu Phe Asn Asp 
            100                 105                 110         


Lys Asn Phe Ser Asp Lys Gln Tyr Phe Glu Lys Phe Pro Thr Ile Phe 
        115                 120                 125             


His Leu Arg Lys Tyr Leu Met Glu Glu His Gly Lys Val Asp Ile Arg 
    130                 135                 140                 


Tyr Tyr Phe Leu Ala Ile Asn Gln Met Met Lys Arg Arg Gly His Phe 
145                 150                 155                 160 


Leu Ile Asp Gly Gln Ile Ser His Val Thr Asp Asp Lys Pro Leu Lys 
                165                 170                 175     


Glu Gln Leu Ile Leu Leu Ile Asn Asp Leu Leu Lys Ile Glu Leu Glu 
            180                 185                 190         


Glu Glu Leu Met Asp Ser Ile Phe Glu Ile Leu Ala Asp Val Asn Glu 
        195                 200                 205             


Lys Arg Thr Asp Lys Lys Asn Asn Leu Lys Glu Leu Ile Lys Gly Gln 
    210                 215                 220                 


Asp Phe Asn Lys Gln Glu Gly Asn Ile Leu Asn Ser Ile Phe Glu Ser 
225                 230                 235                 240 


Ile Val Thr Gly Lys Ala Lys Ile Lys Asn Ile Ile Ser Asp Glu Asp 
                245                 250                 255     


Ile Leu Glu Lys Ile Lys Glu Asp Asn Lys Glu Asp Phe Val Leu Thr 
            260                 265                 270         


Gly Asp Ser Tyr Glu Glu Asn Leu Gln Tyr Phe Glu Glu Val Leu Gln 
        275                 280                 285             


Glu Asn Ile Thr Leu Phe Asn Thr Leu Lys Ser Thr Tyr Asp Phe Leu 
    290                 295                 300                 


Ile Leu Gln Ser Ile Leu Lys Gly Lys Ser Thr Leu Ser Asp Ala Gln 
305                 310                 315                 320 


Val Glu Arg Tyr Asp Glu His Lys Lys Asp Leu Glu Ile Leu Lys Lys 
                325                 330                 335     


Val Ile Lys Lys Tyr Asp Glu Asp Gly Lys Leu Phe Lys Gln Val Phe 
            340                 345                 350         


Lys Glu Asp Asn Gly Asn Gly Tyr Val Ser Tyr Ile Gly Tyr Tyr Leu 
        355                 360                 365             


Asn Lys Asn Lys Lys Ile Thr Ala Lys Lys Lys Ile Ser Asn Ile Glu 
    370                 375                 380                 


Phe Thr Lys Tyr Val Lys Gly Ile Leu Glu Lys Gln Cys Asp Cys Glu 
385                 390                 395                 400 


Asp Glu Asp Val Lys Tyr Leu Leu Gly Lys Ile Glu Gln Glu Asn Phe 
                405                 410                 415     


Leu Leu Lys Gln Ile Ser Ser Ile Asn Ser Val Ile Pro His Gln Ile 
            420                 425                 430         


His Leu Phe Glu Leu Asp Lys Ile Leu Glu Asn Leu Ala Lys Asn Tyr 
        435                 440                 445             


Pro Ser Phe Asn Asn Lys Lys Glu Glu Phe Thr Lys Ile Glu Lys Ile 
    450                 455                 460                 


Arg Lys Thr Phe Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Asn 
465                 470                 475                 480 


Asp Tyr His Lys Asn Asn Gly Gly Asn Ala Trp Ile Phe Arg Asn Lys 
                485                 490                 495     


Gly Glu Lys Ile Arg Pro Trp Asn Phe Glu Lys Ile Val Asp Leu His 
            500                 505                 510         


Lys Ser Glu Glu Glu Phe Ile Lys Arg Met Leu Asn Gln Cys Thr Tyr 
        515                 520                 525             


Leu Pro Glu Glu Thr Val Leu Pro Lys Ser Ser Ile Leu Tyr Ser Glu 
    530                 535                 540                 


Tyr Met Val Leu Asn Glu Leu Asn Asn Leu Arg Ile Asn Gly Lys Pro 
545                 550                 555                 560 


Leu Asp Thr Asp Val Lys Leu Lys Leu Ile Glu Glu Leu Phe Lys Lys 
                565                 570                 575     


Lys Thr Lys Val Thr Leu Lys Ser Ile Arg Asp Tyr Met Val Arg Asn 
            580                 585                 590         


Asn Phe Ala Asp Lys Glu Asp Phe Asp Asn Ser Glu Lys Asn Leu Glu 
        595                 600                 605             


Ile Ala Ser Asn Met Lys Ser Tyr Ile Asp Phe Asn Asn Ile Leu Glu 
    610                 615                 620                 


Asp Lys Phe Asp Val Glu Met Val Glu Asp Leu Ile Glu Lys Ile Thr 
625                 630                 635                 640 


Ile His Thr Gly Asn Lys Lys Leu Leu Lys Lys Tyr Ile Glu Glu Thr 
                645                 650                 655     


Tyr Pro Asp Leu Ser Ser Ser Gln Ile Gln Lys Ile Ile Asn Leu Lys 
            660                 665                 670         


Tyr Lys Asp Trp Gly Arg Leu Ser Arg Lys Leu Leu Asp Gly Ile Lys 
        675                 680                 685             


Gly Thr Lys Lys Glu Thr Glu Lys Thr Asp Thr Val Ile Asn Phe Leu 
    690                 695                 700                 


Arg Asn Ser Ser Asp Asn Leu Met Gln Ile Ile Gly Ser Gln Asn Tyr 
705                 710                 715                 720 


Ser Phe Asn Glu Tyr Ile Asp Lys Leu Arg Lys Lys Tyr Ile Pro Gln 
                725                 730                 735     


Glu Ile Ser Tyr Glu Val Val Glu Asn Leu Tyr Val Ser Pro Ser Val 
            740                 745                 750         


Lys Lys Met Ile Trp Gln Val Ile Arg Val Thr Glu Glu Ile Thr Lys 
        755                 760                 765             


Val Met Gly Tyr Asp Pro Asp Lys Ile Phe Ile Glu Met Ala Lys Ser 
    770                 775                 780                 


Glu Glu Glu Lys Lys Thr Thr Ile Ser Arg Lys Asn Lys Leu Leu Asp 
785                 790                 795                 800 


Leu Tyr Lys Ala Ile Lys Lys Asp Glu Arg Asp Ser Gln Tyr Glu Lys 
                805                 810                 815     


Leu Leu Thr Gly Leu Asn Lys Leu Asp Asp Ser Asp Leu Arg Ser Arg 
            820                 825                 830         


Lys Leu Tyr Leu Tyr Tyr Thr Gln Met Gly Arg Asp Met Tyr Thr Gly 
        835                 840                 845             


Glu Lys Ile Asp Leu Asp Lys Leu Phe Asp Ser Thr His Tyr Asp Lys 
    850                 855                 860                 


Asp His Ile Ile Pro Gln Ser Met Lys Lys Asp Asp Ser Ile Ile Asn 
865                 870                 875                 880 


Asn Leu Val Leu Val Asn Lys Asn Ala Asn Gln Thr Thr Lys Gly Asn 
                885                 890                 895     


Ile Tyr Pro Val Pro Ser Ser Ile Arg Asn Asn Pro Lys Ile Tyr Asn 
            900                 905                 910         


Tyr Trp Lys Tyr Leu Met Glu Lys Glu Phe Ile Ser Lys Glu Lys Tyr 
        915                 920                 925             


Asn Arg Leu Ile Arg Asn Thr Pro Leu Thr Asn Glu Glu Leu Gly Gly 
    930                 935                 940                 


Phe Ile Asn Arg Gln Leu Val Glu Thr Arg Gln Ser Thr Lys Ala Ile 
945                 950                 955                 960 


Lys Glu Leu Phe Glu Lys Phe Tyr Gln Lys Ser Lys Ile Ile Pro Val 
                965                 970                 975     


Lys Ala Ser Leu Ala Ser Asp Leu Arg Lys Asp Met Asn Thr Leu Lys 
            980                 985                 990         


Ser Arg Glu Val Asn Asp Leu His  His Ala His Asp Ala  Phe Leu Asn 
        995                 1000                 1005             


Ile Val  Ala Gly Asp Val Trp  Asn Arg Glu Phe Thr  Ser Asn Pro 
    1010                 1015                 1020             


Ile Asn  Tyr Val Lys Glu Asn  Arg Glu Gly Asp Lys  Val Lys Tyr 
    1025                 1030                 1035             


Ser Leu  Ser Lys Asp Phe Thr  Arg Pro Arg Lys Ser  Lys Gly Lys 
    1040                 1045                 1050             


Val Ile  Trp Thr Pro Glu Lys  Gly Arg Lys Leu Ile  Val Asp Thr 
    1055                 1060                 1065             


Leu Asn  Lys Pro Ser Val Leu  Ile Ser Asn Glu Ser  His Val Lys 
    1070                 1075                 1080             


Lys Gly  Glu Leu Phe Asn Ala  Thr Ile Ala Gly Lys  Lys Asp Tyr 
    1085                 1090                 1095             


Lys Lys  Gly Lys Ile Tyr Leu  Pro Leu Lys Lys Asp  Asp Arg Leu 
    1100                 1105                 1110             


Gln Asp  Val Ser Lys Tyr Gly  Gly Tyr Lys Ala Ile  Asn Gly Ala 
    1115                 1120                 1125             


Phe Phe  Phe Leu Val Glu His  Thr Lys Ser Lys Lys  Arg Ile Arg 
    1130                 1135                 1140             


Ser Ile  Glu Leu Phe Pro Leu  His Leu Leu Ser Lys  Phe Tyr Glu 
    1145                 1150                 1155             


Asp Lys  Asn Thr Val Leu Asp  Tyr Ala Ile Asn Val  Leu Gln Leu 
    1160                 1165                 1170             


Gln Asp  Pro Lys Ile Ile Ile  Asp Lys Ile Asn Tyr  Arg Thr Glu 
    1175                 1180                 1185             


Ile Ile  Ile Asp Asn Phe Ser  Tyr Leu Ile Ser Thr  Lys Ser Asn 
    1190                 1195                 1200             


Asp Gly  Ser Ile Thr Val Lys  Pro Asn Glu Gln Met  Tyr Trp Arg 
    1205                 1210                 1215             


Val Asp  Glu Ile Ser Asn Leu  Lys Lys Ile Glu Asn  Lys Tyr Lys 
    1220                 1225                 1230             


Lys Asp  Ala Ile Leu Thr Glu  Glu Asp Arg Lys Ile  Met Glu Ser 
    1235                 1240                 1245             


Tyr Ile  Asp Lys Ile Tyr Gln  Gln Phe Lys Ala Gly  Lys Tyr Lys 
    1250                 1255                 1260             


Asn Arg  Arg Thr Thr Asp Thr  Ile Ile Glu Lys Tyr  Glu Ile Ile 
    1265                 1270                 1275             


Asp Leu  Asp Thr Leu Asp Asn  Lys Gln Leu Tyr Gln  Leu Leu Val 
    1280                 1285                 1290             


Ala Phe  Ile Ser Leu Ser Tyr  Lys Thr Ser Asn Asn  Ala Val Asp 
    1295                 1300                 1305             


Phe Thr  Val Ile Gly Leu Gly  Thr Glu Cys Gly Lys  Pro Arg Ile 
    1310                 1315                 1320             


Thr Asn  Leu Pro Asp Asn Thr  Tyr Leu Val Tyr Lys  Ser Ile Thr 
    1325                 1330                 1335             


Gly Ile  Tyr Glu Lys Arg Ile  Arg Ile Lys 
    1340                 1345             


<210> 219
<211> 1348
<212> PRT
<213> Finegoldia magna


<220>
<223> Finegoldia magna SY403409CC001050417

<400> 219
Met Lys Ser Glu Lys Lys Tyr Tyr Ile Gly Leu Asp Val Gly Thr Asn 
1               5                   10                  15      


Ser Val Gly Trp Ala Val Thr Asp Glu Phe Tyr Asn Ile Leu Arg Ala 
            20                  25                  30          


Lys Gly Lys Asp Leu Trp Gly Val Arg Leu Phe Glu Lys Ala Lys Thr 
        35                  40                  45              


Ala Ala Asp Thr Arg Thr Phe Arg Ser Gly Arg Arg Arg Asn Asp Arg 
    50                  55                  60                  


Lys Gly Val Arg Leu Gln Ile Leu Arg Glu Ile Phe Glu Asp Glu Ile 
65                  70                  75                  80  


Lys Lys Val Asp Lys Asp Phe Tyr Asp Arg Leu Asp Glu Ser Lys Phe 
                85                  90                  95      


Trp Ala Glu Asp Lys Lys Val Ser Gly Lys Tyr Ser Leu Phe Asn Asp 
            100                 105                 110         


Lys Asn Phe Ser Asp Lys Gln Tyr Phe Glu Lys Phe Pro Thr Ile Phe 
        115                 120                 125             


His Leu Arg Lys Tyr Leu Met Glu Glu His Gly Lys Val Asp Ile Arg 
    130                 135                 140                 


Tyr Tyr Phe Leu Ala Ile Asn Gln Met Met Lys Arg Arg Gly His Phe 
145                 150                 155                 160 


Leu Ile Asp Gly Gln Ile Ser His Val Thr Asp Asp Lys Pro Leu Lys 
                165                 170                 175     


Gln Gln Leu Ile Leu Leu Ile Asn Asp Leu Leu Lys Ile Glu Leu Glu 
            180                 185                 190         


Glu Glu Phe Met Asp Ser Ile Phe Glu Ile Leu Ala Asp Val Asn Glu 
        195                 200                 205             


Lys Lys Thr Glu Lys Lys Asn Ile Leu Lys Glu Leu Ile Asn Ala Gln 
    210                 215                 220                 


Asp Phe Asn Lys Gln Glu Gly Lys Ile Leu Tyr Ser Ile Phe Glu Ser 
225                 230                 235                 240 


Ile Val Thr Gly Lys Ala Lys Ile Lys Asn Ile Ile Ser Asp Glu Asp 
                245                 250                 255     


Ile Leu Glu Lys Ile Lys Glu Asp Asn Lys Glu Asp Phe Val Leu Thr 
            260                 265                 270         


Gly Asp Ser Tyr Glu Glu Asn Leu Gln Tyr Phe Glu Glu Val Leu Gln 
        275                 280                 285             


Glu Asn Ile Thr Leu Phe Asn Thr Leu Lys Ser Ala Tyr Asp Phe Val 
    290                 295                 300                 


Ile Leu Gln Ser Ile Leu Lys Gly Lys Ser Thr Leu Ser Asp Ala Gln 
305                 310                 315                 320 


Val Glu Arg Tyr Asp Glu His Lys Lys Asp Leu Glu Ile Leu Lys Lys 
                325                 330                 335     


Val Ile Lys Lys Tyr Asp Glu Asp Gly Lys Leu Phe Lys Gln Val Phe 
            340                 345                 350         


Lys Glu Asp Asn Gly Asn Gly Tyr Val Ser Tyr Ile Gly Tyr Tyr Leu 
        355                 360                 365             


Asn Lys Asn Lys Lys Ile Thr Ala Lys Lys Lys Ile Ser Asn Ile Glu 
    370                 375                 380                 


Phe Thr Lys Tyr Val Lys Gly Ile Leu Glu Lys Gln Cys Asp Cys Glu 
385                 390                 395                 400 


Asp Glu Asp Val Lys Tyr Leu Leu Gly Lys Ile Glu Gln Glu Asn Phe 
                405                 410                 415     


Leu Leu Lys Gln Ile Ser Ser Ile Asn Ser Val Ile Pro His Gln Ile 
            420                 425                 430         


His Leu Phe Glu Leu Asp Lys Ile Leu Glu Asn Leu Ala Lys Tyr Tyr 
        435                 440                 445             


Pro Ser Phe Asn Asn Lys Lys Glu Glu Phe Thr Lys Ile Glu Lys Ile 
    450                 455                 460                 


Arg Lys Thr Phe Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Asn 
465                 470                 475                 480 


Asp Tyr His Lys Asn Asn Gly Gly Asn Ala Trp Ile Phe Arg Asn Lys 
                485                 490                 495     


Gly Glu Lys Ile Arg Pro Trp Asn Phe Glu Lys Ile Val Asp Leu His 
            500                 505                 510         


Lys Ser Glu Glu Glu Phe Ile Lys Arg Met Leu Asn Gln Cys Thr Tyr 
        515                 520                 525             


Leu Pro Glu Glu Thr Val Leu Pro Lys Ser Ser Ile Leu Tyr Ser Glu 
    530                 535                 540                 


Tyr Met Val Leu Asn Glu Leu Asn Asn Leu Arg Ile Asn Gly Lys Pro 
545                 550                 555                 560 


Ile Asp Thr Asp Val Lys Leu Lys Leu Ile Glu Glu Leu Phe Lys Lys 
                565                 570                 575     


Lys Thr Lys Val Thr Leu Lys Ser Ile Arg Asp Tyr Met Ile Arg Asn 
            580                 585                 590         


Asn Phe Ala Asp Lys Glu Asp Phe Asp Asn Ser Glu Lys Asn Leu Glu 
        595                 600                 605             


Ile Val Ser Asn Met Lys Ser Tyr Ile Asp Phe Asn Asn Ile Leu Gly 
    610                 615                 620                 


Asp Lys Phe Glu Leu Glu Met Val Glu Asp Leu Ile Glu Lys Ile Thr 
625                 630                 635                 640 


Ile His Thr Gly Asn Lys Lys Leu Leu Lys Lys Tyr Ile Glu Glu Thr 
                645                 650                 655     


Tyr Pro Asp Leu Ser Ser Ser Gln Ile Gln Lys Ile Ile Asn Leu Lys 
            660                 665                 670         


Tyr Lys Asp Trp Gly Arg Leu Ser Arg Lys Leu Leu Asp Gly Ile Thr 
        675                 680                 685             


Gly Thr Asn Ile Glu Thr Gly Glu Ile Asp Thr Val Ile Asn Phe Leu 
    690                 695                 700                 


Arg Asn Ser Ser Asp Asn Leu Met Gln Ile Ile Gly Ser Gln Asn Tyr 
705                 710                 715                 720 


Ser Phe Asn Asn Asp Ile Asp Lys Leu Arg Lys Lys Tyr Ile Pro Gln 
                725                 730                 735     


Glu Ile Ser Tyr Glu Val Val Glu Asn Leu Tyr Val Ser Pro Ser Val 
            740                 745                 750         


Lys Lys Met Ile Trp Gln Val Ile Arg Ile Thr Glu Glu Ile Thr Lys 
        755                 760                 765             


Val Met Gly Tyr Asp Pro Asp Lys Ile Phe Ile Glu Met Ala Lys Ser 
    770                 775                 780                 


Glu Glu Gly Lys Lys Thr Thr Ile Ser Arg Lys Asn Lys Leu Leu Ala 
785                 790                 795                 800 


Leu Tyr Lys Ala Ile Lys Lys Asp Glu Arg Asp Ser Gln Tyr Glu Lys 
                805                 810                 815     


Leu Leu Thr Gly Leu Asn Lys Leu Asp Asp Ser Asp Leu Arg Ser Arg 
            820                 825                 830         


Lys Leu Tyr Leu Tyr Tyr Thr Gln Met Gly Arg Asp Met Tyr Thr Gly 
        835                 840                 845             


Glu Lys Ile Asp Leu Asp Lys Leu Phe Asp Ser Thr His Tyr Asp Lys 
    850                 855                 860                 


Asp His Ile Ile Pro Gln Ser Met Lys Lys Asp Asp Ser Ile Ile Asn 
865                 870                 875                 880 


Asn Leu Val Leu Val Asn Lys Asn Ala Asn Gln Thr Thr Lys Gly Asn 
                885                 890                 895     


Ile Tyr Pro Val Pro Ser Ser Ile Arg Asn Asn Pro Lys Ile Tyr Asn 
            900                 905                 910         


Tyr Trp Lys Tyr Leu Met Glu Lys Glu Phe Ile Ser Lys Glu Lys Tyr 
        915                 920                 925             


Asn Arg Leu Ile Arg Asn Thr Pro Leu Thr Asn Glu Glu Leu Gly Gly 
    930                 935                 940                 


Phe Ile Asn Arg Gln Leu Val Glu Thr Arg Gln Ser Thr Lys Ala Ile 
945                 950                 955                 960 


Lys Glu Leu Phe Glu Lys Phe Tyr Lys Lys Ser Lys Ile Ile Pro Val 
                965                 970                 975     


Lys Ala Ile Leu Ala Ser Asp Leu Arg Lys Asp Met Asn Thr Leu Lys 
            980                 985                 990         


Ser Arg Glu Val Asn Asp Leu His  His Ala His Asp Ala  Phe Leu Asn 
        995                 1000                 1005             


Ile Val  Ala Gly Asp Val Trp  Asn Arg Glu Phe Thr  Ser Asn Pro 
    1010                 1015                 1020             


Ile Asn  Tyr Val Lys Glu Asn  Arg Glu Gly Asp Lys  Val Lys Tyr 
    1025                 1030                 1035             


Ser Leu  Ser Lys Tyr Phe Thr  Arg Pro Arg Lys Ser  Lys Gly Lys 
    1040                 1045                 1050             


Val Ile  Trp Thr Pro Glu Lys  Gly Arg Lys Leu Ile  Val Asp Thr 
    1055                 1060                 1065             


Leu Asn  Lys Pro Ser Val Leu  Ile Ser Asn Glu Ser  His Val Lys 
    1070                 1075                 1080             


Lys Gly  Glu Leu Phe Asn Ala  Thr Ile Ala Gly Lys  Lys Asp Tyr 
    1085                 1090                 1095             


Lys Lys  Gly Lys Ile Tyr Leu  Pro Leu Lys Lys Asp  Asp Arg Leu 
    1100                 1105                 1110             


Gln Asp  Val Ser Lys Tyr Gly  Gly Tyr Lys Ala Ile  Asn Gly Ala 
    1115                 1120                 1125             


Phe Phe  Phe Leu Val Glu His  Thr Lys Ser Lys Lys  Arg Ile Arg 
    1130                 1135                 1140             


Ser Ile  Glu Leu Phe Pro Leu  His Leu Leu Ser Lys  Phe Tyr Glu 
    1145                 1150                 1155             


Asp Lys  Asn Thr Val Leu Asp  Tyr Ala Ile Asn Val  Leu Gln Leu 
    1160                 1165                 1170             


Gln Asp  Pro Lys Ile Ile Ile  Asp Lys Ile Asn Tyr  Arg Thr Glu 
    1175                 1180                 1185             


Ile Ile  Ile Asp Asn Phe Ser  Tyr Leu Ile Ser Thr  Lys Ser Asn 
    1190                 1195                 1200             


Asp Gly  Ser Ile Thr Val Lys  Pro Asn Glu Gln Met  Tyr Trp Arg 
    1205                 1210                 1215             


Val Asp  Glu Ile Ser Asn Leu  Lys Lys Ile Glu Asn  Lys Tyr Lys 
    1220                 1225                 1230             


Lys Asp  Ala Ile Leu Thr Glu  Glu Asp Arg Lys Ile  Met Glu Ser 
    1235                 1240                 1245             


Tyr Ile  Asp Lys Ile Tyr Gln  Gln Phe Lys Ala Gly  Lys Tyr Lys 
    1250                 1255                 1260             


Asn Arg  Arg Thr Thr Asp Thr  Ile Ile Glu Lys Tyr  Glu Ile Ile 
    1265                 1270                 1275             


Asp Leu  Asp Thr Leu Asp Asn  Lys Gln Leu Tyr Gln  Leu Leu Val 
    1280                 1285                 1290             


Ala Phe  Ile Ser Leu Ser Tyr  Lys Thr Ser Asn Asn  Ala Val Asp 
    1295                 1300                 1305             


Phe Thr  Val Ile Gly Leu Gly  Thr Glu Cys Gly Lys  Pro Arg Ile 
    1310                 1315                 1320             


Thr Asn  Leu Pro Asp Asn Thr  Tyr Leu Val Tyr Lys  Ser Ile Thr 
    1325                 1330                 1335             


Gly Ile  Tyr Glu Lys Arg Ile  Arg Ile Lys 
    1340                 1345             


<210> 220
<211> 1516
<212> PRT
<213> Flavobacteriaceae bacterium


<220>
<223> Flavobacteriaceae bacterium S85

<400> 220
Met Leu Lys Gln Gln Lys Asp Lys Ile Ile Gly Met Asn Lys Lys Ile 
1               5                   10                  15      


Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp Ala Leu Val Lys 
            20                  25                  30          


Gln Asp Leu Glu Asn Lys Tyr Gly Glu Ile Ile Gly Cys Gly Ser Arg 
        35                  40                  45              


Ile Ile Pro Met Ser Gln Asp Val Leu Gly Lys Phe Asp Ala Gly Ile 
    50                  55                  60                  


Ser Ile Ser Gln Thr Ala Glu Arg Thr Asn Tyr Arg Ser Val Arg Lys 
65                  70                  75                  80  


Leu Ile Gln Arg Asn Thr Leu Arg Arg Glu Arg Leu His Arg Val Leu 
                85                  90                  95      


His Gln Leu Asp Phe Leu Pro Lys His Tyr Asn Asp Ser Ile Asp Phe 
            100                 105                 110         


Glu Lys Lys Leu Gly Gln Phe Lys Thr Asp Lys Glu Thr Lys Leu Asn 
        115                 120                 125             


Tyr Phe Val Asn Gln His Gly Lys His Glu Phe Leu Phe Lys Asp Ser 
    130                 135                 140                 


Phe Asn Glu Met Val Lys Glu Phe Lys Glu Glu Gln Pro Glu Leu Phe 
145                 150                 155                 160 


Tyr Ile Lys Asn Asn Gly Lys Glu Thr Lys Ile Pro Tyr Asp Trp Thr 
                165                 170                 175     


Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Ser Lys Lys Ile Ser Lys Glu 
            180                 185                 190         


Glu Leu Ser Trp Leu Val Leu Asn Phe Asn Gln Lys Arg Gly Tyr Tyr 
        195                 200                 205             


Gln Leu Arg Gly Glu Ile Asp Glu Glu Lys Glu Lys Asn Lys Arg Tyr 
    210                 215                 220                 


Glu Lys Leu Tyr Val Ser Glu Val Val Lys Thr Asn Asn Thr Ile Lys 
225                 230                 235                 240 


Lys Thr Gly Glu Tyr Leu Tyr Asp Ile Tyr Phe Asp Asn Gly Trp Lys 
                245                 250                 255     


Tyr Glu Lys Gln Thr Thr Lys Pro Gln Asp Trp Leu His Lys His Lys 
            260                 265                 270         


Glu Phe Ile Ile Thr Thr Thr Thr Leu Lys Asn Gly Glu Thr Lys Arg 
        275                 280                 285             


Thr Phe Lys Thr Val Asp Ser Glu Lys Asp Trp Ile Ala Ile Lys Ser 
    290                 295                 300                 


Lys Thr Glu Gln Asp Ile Lys Glu Ser Asn Lys Thr Val Gly Ala Phe 
305                 310                 315                 320 


Ile Tyr Asp Thr Leu Leu Lys Asn Pro Thr Gln Lys Ile Arg Gly Ser 
                325                 330                 335     


Leu Val Lys Thr Ile Glu Arg Lys Phe Tyr Arg Glu Glu Phe Glu Lys 
            340                 345                 350         


Ile Leu Lys Glu Gln Ile Lys His Arg Pro Glu Ile Asn Val Asn Thr 
        355                 360                 365             


Ala Ile Gly Lys Glu Asn Tyr Thr Lys Cys Val Thr Glu Leu Tyr Pro 
    370                 375                 380                 


Arg Asn Glu Ala His Ala Asn Asn Ile Leu Thr Asn Asp Phe Asn Tyr 
385                 390                 395                 400 


Leu Phe Thr Lys Asp Ile Leu Phe Tyr Gln Arg Pro Leu Lys Ser Lys 
                405                 410                 415     


Lys Ser Glu Ile Ala Asn Cys Gln Tyr Glu Tyr Arg Thr Tyr Ile Lys 
            420                 425                 430         


Lys Lys Glu Lys Thr Gly Lys Glu Glu Arg Val Lys Gln Pro Leu Lys 
        435                 440                 445             


Ala Thr Pro Lys Ser His Pro Leu Phe Gln Glu Phe Arg Leu Trp Gln 
    450                 455                 460                 


Phe Ile His Asn Leu Lys Ile Tyr Ile Arg Glu Thr Thr Val Gly Asn 
465                 470                 475                 480 


Lys Pro Leu Phe Asp Val Asp Ile Thr Asp Thr Phe Phe Thr Ser Glu 
                485                 490                 495     


Asn Asp Trp Ala Thr Leu Phe Glu Tyr Leu Asn Asn Lys Lys Glu Ile 
            500                 505                 510         


Glu Gln Lys His Val Leu Glu Tyr Leu Val Ser Lys Lys Ile Ile Ser 
        515                 520                 525             


Lys Ser Glu Lys Thr Asp Tyr Arg Trp Asn Tyr Val Glu Asp Lys Lys 
    530                 535                 540                 


Tyr Pro Gly Asn Glu Thr Arg Val Asp Phe Ile Asn Arg Leu Lys Lys 
545                 550                 555                 560 


Val Glu Asn Leu Asn Val Asp Glu Phe Leu Thr Ser Glu Leu Glu Phe 
                565                 570                 575     


Lys Leu Trp His Ile Ile Tyr Ser Val Thr Asp Lys Asn Glu Tyr Glu 
            580                 585                 590         


Lys Ala Leu Glu Asn Phe Ala Ile Arg Gln Asn Ile Asp Lys Asp Ser 
        595                 600                 605             


Phe Val Asn Ser Phe Lys Lys Phe Pro Pro Phe Lys Ser Asp Tyr Gly 
    610                 615                 620                 


Ala Tyr Ser Thr Lys Ala Ile Lys Lys Leu Leu Pro Leu Met Arg Leu 
625                 630                 635                 640 


Gly Lys Phe Trp Asp Gly Ser Glu Ile Pro Lys Val Val Val Glu Lys 
                645                 650                 655     


Ile Thr Asp Ile Lys Thr Arg Leu Thr Ser Val Asn Tyr Asp Glu Ser 
            660                 665                 670         


Leu Phe Lys Lys Asp Glu Lys Lys Ile Leu Glu Thr Ile Val Asp Asp 
        675                 680                 685             


Ile Thr Pro Lys Gln Leu Leu Lys Ser Phe Val Lys Leu Lys Gly Lys 
    690                 695                 700                 


Asn His Leu Ala Gly Leu Asn Thr Tyr Gln Ala Cys Tyr Leu Val Tyr 
705                 710                 715                 720 


Glu Arg His Ser Glu Ser Ser Asp Ile Thr Gln Trp Glu Asn Pro Asp 
                725                 730                 735     


Asp Ile Asp Ser Phe Leu Asn His Phe Lys Gln His Ser Leu Arg Asn 
            740                 745                 750         


Pro Ile Val Glu Gln Val Val Thr Glu Thr Leu Arg Thr Val Arg Asp 
        755                 760                 765             


Ile Trp Lys Tyr Tyr Gly Asn Gly Ser Pro Asn Tyr Phe Asn Glu Ile 
    770                 775                 780                 


His Ile Glu Leu Gly Arg Glu Met Lys Asn Pro Ala Asp Lys Arg Lys 
785                 790                 795                 800 


Gln Met Ser Ala Lys Ile Asn Glu Asn Glu Asn Thr Asn Gln Arg Ile 
                805                 810                 815     


Lys Gly Ile Leu Gln Glu Leu Met Asn Asp Gly Val Gln Asp Ile Lys 
            820                 825                 830         


Pro Tyr Ser Pro Ser Gln Gln Glu Ile Leu Lys Ile Tyr Glu Glu Gly 
        835                 840                 845             


Ile Ser Gln Asn Pro Asn Val Asp Tyr Ser Lys Val Ser Glu Asp Glu 
    850                 855                 860                 


Ile Thr Lys Ile Lys Lys Ser Asn Asn Pro Thr Leu Lys Glu Ile Gln 
865                 870                 875                 880 


Arg Tyr Lys Leu Trp Leu Glu Gln Lys Tyr Ile Ser Pro Tyr Thr Gly 
                885                 890                 895     


Lys Pro Ile Pro Leu Ser Glu Leu Phe Thr Pro Ala Tyr Gln Ile Glu 
            900                 905                 910         


His Ile Ile Pro Gln Ser Arg Tyr Phe Asp Asn Ser Leu Ser Asn Lys 
        915                 920                 925             


Ile Ile Cys Glu Ser Glu Val Asn Glu Asp Lys Ser Asn Lys Thr Ala 
    930                 935                 940                 


Tyr Glu Tyr Leu Lys Thr Asn Gly Gly Ser Ile Val His Gly His His 
945                 950                 955                 960 


Leu Leu Ser Leu Lys Glu Tyr Glu Asp His Cys Gln His Tyr Phe Lys 
                965                 970                 975     


Lys Asn Arg Thr Lys Leu Lys Asn Leu Leu Ser Glu Glu Ile Pro Glu 
            980                 985                 990         


Gly Phe Ile Asn Arg Gln Leu Asn  Asp Ser Arg Tyr Ile  Ser Lys Leu 
        995                 1000                 1005             


Ile Lys  Gly Leu Leu Ser Asn  Ile Val Arg Glu Glu  Asn Glu Gln 
    1010                 1015                 1020             


Glu Ala  Thr Ser Lys Asn Ile  Val Pro Val Thr Gly  Ser Ile Thr 
    1025                 1030                 1035             


Ser Lys  Leu Lys Gln Asp Trp  Gly Leu Asn Asp Lys  Trp Asn Glu 
    1040                 1045                 1050             


Ile Ile  Ala Pro Arg Phe Lys  Arg Leu Asn Lys Met  Thr Asn Ser 
    1055                 1060                 1065             


Asn Asp  Phe Gly Tyr Phe Asp  Glu Lys Ile Asn Thr  Phe Arg Ile 
    1070                 1075                 1080             


Gln Val  Pro Asp Ala Ile Ser  Arg Gly Phe Asn Lys  Lys Arg Ile 
    1085                 1090                 1095             


Asp His  Arg His His Thr Leu  Asp Ala Leu Val Ile  Ala Cys Cys 
    1100                 1105                 1110             


Thr Lys  Lys His Ile Gln Tyr  Leu Asn Ser Leu Asn  Asn Glu Ile 
    1115                 1120                 1125             


Ile Lys  His Glu Leu Lys Pro  Ser Ile Leu Ile Lys  Asn Ala Gln 
    1130                 1135                 1140             


Gly Asp  Tyr Thr Lys His Phe  Met Leu Pro Trp Asn  Asn Phe Pro 
    1145                 1150                 1155             


Ile Asp  Cys Lys Asn Ala Ile  Glu Asn Thr Ile Val  Ser Phe Lys 
    1160                 1165                 1170             


Gln Asn  Leu Arg Val Ile Asn  Lys Thr Ser Asn Lys  Tyr Gln Ser 
    1175                 1180                 1185             


Tyr Lys  Asp Glu Asn Gly Asn  Leu Arg Leu Gly Lys  Asp Gly Lys 
    1190                 1195                 1200             


Pro Lys  Lys Gly Leu Thr Lys  Gln Thr Lys Gly Asn  Asn Trp Ala 
    1205                 1210                 1215             


Val Arg  Lys Ala Met His Glu  Asp Thr Phe Tyr Gly  Glu Ile Val 
    1220                 1225                 1230             


Asp Gly  Glu Asn Lys Gly Lys  Leu Lys Ile Lys Thr  Leu Leu Asp 
    1235                 1240                 1245             


Thr Ser  Phe Asp Val Lys Lys  Ile Glu Asp Lys Val  Leu Asp Lys 
    1250                 1255                 1260             


Ser Ile  Arg Thr Ile Leu Ile  Asn Tyr Leu Lys Gln  Asp Lys Tyr 
    1265                 1270                 1275             


Lys Asn  Leu Ser Lys Pro His  Glu Glu Ala Phe Ser  Pro Asn Gly 
    1280                 1285                 1290             


Ile Ile  Glu Met Asn Lys Asn  Ile Ile Ser Leu Asn  Asn Asn Ile 
    1295                 1300                 1305             


Pro His  Lys Pro Ile Lys Arg  Val Thr Leu Lys His  Glu Lys Gly 
    1310                 1315                 1320             


Lys Lys  Phe Ser Ile Lys Thr  Leu Leu Asp Lys Lys  Thr Lys Phe 
    1325                 1330                 1335             


Ala Lys  Ser Ala Thr Gly Thr  Asn Val Phe Phe Cys  Ile Tyr Lys 
    1340                 1345                 1350             


Asn Ile  Asn Gly Lys Ile Lys  Tyr His Thr Pro Ser  Phe Glu Glu 
    1355                 1360                 1365             


Ile Ile  Glu Ile Gln Lys Gln  Glu Phe Glu Ile Lys  Tyr Lys Ser 
    1370                 1375                 1380             


Lys Leu  Asn Val Pro Glu Thr  Leu Phe Asp Lys Lys  Glu Ser Phe 
    1385                 1390                 1395             


Glu Leu  Leu Phe Tyr Leu Gln  Pro Asn Asp Leu Val  Tyr Leu Pro 
    1400                 1405                 1410             


Asn Asp  Glu Glu Leu Lys Asn  Arg Gln Leu Ile Asp  Phe Asn Asn 
    1415                 1420                 1425             


Leu Asn  Lys Lys Gln Ile Lys  Arg Ile Tyr Lys Phe  Thr Asp Gly 
    1430                 1435                 1440             


Ser Gly  Thr Thr Ala Asn Phe  Ile Pro Tyr Gln Val  Ala Lys Val 
    1445                 1450                 1455             


Ile Phe  Asn Leu Asn Lys Lys  Glu Gln Ala Lys Ser  Ser Phe Lys 
    1460                 1465                 1470             


Tyr Pro  Ile Gln Asn Glu Phe  Gly Val Gly Ser Pro  Gln Ser Lys 
    1475                 1480                 1485             


Asn Gln  Lys Ser Ile Glu Gly  Ile Leu Ile Lys Glu  Arg Cys Ile 
    1490                 1495                 1500             


Lys Leu  Lys Ile Asp Arg Leu  Gly Asn Ile Ser Lys  Ala 
    1505                 1510                 1515     


<210> 221
<211> 1473
<212> PRT
<213> Flavobacterium branchiophilum

<400> 221
Met Ala Lys Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Val Val Glu Arg Glu Asn Ile Asp Phe Ser Leu Ile Asp Lys Gly 
            20                  25                  30          


Val Arg Ile Phe Ser Glu Gly Val Lys Ser Glu Lys Gly Ile Glu Ser 
        35                  40                  45              


Ser Arg Ala Ala Glu Arg Thr Gly Tyr Arg Ser Ala Arg Lys Ile Lys 
    50                  55                  60                  


Tyr Arg Arg Lys Leu Arg Lys Tyr Glu Thr Leu Lys Val Leu Ser Leu 
65                  70                  75                  80  


Asn Arg Met Cys Pro Leu Ser Ile Glu Glu Val Glu Glu Trp Lys Lys 
                85                  90                  95      


Ser Gly Phe Lys Asp Tyr Pro Leu Asn Pro Glu Phe Leu Lys Trp Leu 
            100                 105                 110         


Ser Thr Asp Glu Glu Ser Asn Val Asn Pro Tyr Phe Phe Arg Asp Arg 
        115                 120                 125             


Ala Ser Lys His Lys Val Ser Leu Phe Glu Leu Gly Arg Ala Phe Tyr 
    130                 135                 140                 


His Ile Ala Gln Arg Arg Gly Phe Leu Ser Asn Arg Leu Asp Gln Ser 
145                 150                 155                 160 


Ala Glu Gly Ile Leu Glu Glu His Cys Pro Lys Ile Glu Ala Ile Val 
                165                 170                 175     


Glu Asp Leu Ile Ser Ile Asp Glu Ile Ser Thr Asn Ile Thr Asp Tyr 
            180                 185                 190         


Phe Phe Glu Thr Gly Ile Leu Asp Ser Asn Glu Lys Asn Gly Tyr Ala 
        195                 200                 205             


Lys Asp Leu Asp Glu Gly Asp Lys Lys Leu Val Ser Leu Tyr Lys Ser 
    210                 215                 220                 


Leu Leu Ala Ile Leu Lys Lys Asn Glu Ser Asp Phe Glu Asn Cys Lys 
225                 230                 235                 240 


Ser Glu Ile Ile Glu Arg Leu Asn Lys Lys Asp Val Leu Gly Lys Val 
                245                 250                 255     


Lys Gly Lys Ile Lys Asp Ile Ser Gln Ala Met Leu Asp Gly Asn Tyr 
            260                 265                 270         


Lys Thr Leu Gly Gln Tyr Phe Tyr Ser Leu Tyr Ser Lys Glu Lys Ile 
        275                 280                 285             


Arg Asn Gln Tyr Thr Ser Arg Glu Glu His Tyr Leu Ser Glu Phe Ile 
    290                 295                 300                 


Thr Ile Cys Lys Val Gln Gly Ile Asp Gln Ile Asn Glu Glu Glu Lys 
305                 310                 315                 320 


Ile Asn Glu Lys Lys Phe Asp Gly Leu Ala Lys Asp Leu Tyr Lys Ala 
                325                 330                 335     


Ile Phe Phe Gln Arg Pro Leu Lys Ser Gln Lys Gly Leu Ile Gly Lys 
            340                 345                 350         


Cys Ser Phe Glu Lys Ser Lys Ser Arg Cys Ala Ile Ser His Pro Asp 
        355                 360                 365             


Phe Glu Glu Tyr Arg Met Trp Thr Tyr Leu Asn Thr Ile Lys Ile Gly 
    370                 375                 380                 


Thr Gln Ser Asp Lys Lys Leu Arg Phe Leu Thr Gln Asp Glu Lys Leu 
385                 390                 395                 400 


Lys Leu Val Pro Lys Phe Tyr Arg Lys Asn Asp Phe Asn Phe Asp Val 
                405                 410                 415     


Leu Ala Lys Glu Leu Ile Glu Lys Gly Ser Ser Phe Gly Phe Tyr Lys 
            420                 425                 430         


Ser Ser Lys Lys Asn Asp Phe Phe Tyr Trp Phe Asn Tyr Lys Pro Thr 
        435                 440                 445             


Asp Thr Val Ala Ala Cys Gln Val Ala Ala Ser Leu Lys Asn Ala Ile 
    450                 455                 460                 


Gly Glu Asp Trp Lys Thr Lys Ser Phe Lys Tyr Gln Thr Ile Asn Ser 
465                 470                 475                 480 


Asn Lys Glu Gln Val Ser Arg Thr Val Asp Tyr Lys Asp Leu Trp His 
                485                 490                 495     


Leu Leu Thr Val Ala Thr Ser Asp Val Tyr Leu Tyr Glu Phe Ala Ile 
            500                 505                 510         


Asp Lys Leu Gly Leu Asp Glu Lys Asn Ala Lys Ala Phe Ser Lys Thr 
        515                 520                 525             


Lys Leu Lys Lys Asp Phe Ala Ser Leu Ser Leu Ser Ala Ile Asn Lys 
    530                 535                 540                 


Ile Leu Pro Tyr Leu Lys Glu Gly Leu Leu Tyr Ser His Ala Val Phe 
545                 550                 555                 560 


Val Ala Asn Ile Glu Asn Ile Val Asp Glu Asn Ile Trp Lys Asp Glu 
                565                 570                 575     


Lys Gln Arg Asp Tyr Ile Lys Thr Gln Ile Ser Glu Ile Ile Glu Asn 
            580                 585                 590         


Tyr Thr Leu Glu Lys Ser Arg Phe Glu Ile Ile Asn Gly Leu Leu Lys 
        595                 600                 605             


Glu Tyr Lys Ser Glu Asn Glu Asp Gly Lys Arg Val Tyr Tyr Ser Lys 
    610                 615                 620                 


Glu Ala Glu Gln Ser Phe Glu Asn Asp Leu Lys Lys Lys Leu Val Leu 
625                 630                 635                 640 


Phe Tyr Lys Ser Asn Glu Ile Glu Asn Lys Glu Gln Gln Glu Thr Ile 
                645                 650                 655     


Phe Asn Glu Leu Leu Pro Ile Phe Ile Gln Gln Leu Lys Asp Tyr Glu 
            660                 665                 670         


Phe Ile Lys Ile Gln Arg Leu Asp Gln Lys Val Leu Ile Phe Leu Lys 
        675                 680                 685             


Gly Lys Asn Glu Thr Gly Gln Ile Phe Cys Thr Glu Glu Lys Gly Thr 
    690                 695                 700                 


Ala Glu Glu Lys Glu Lys Lys Ile Lys Asn Arg Leu Lys Lys Leu Tyr 
705                 710                 715                 720 


His Pro Ser Asp Ile Glu Lys Phe Lys Lys Lys Ile Ile Lys Asp Glu 
                725                 730                 735     


Phe Gly Asn Glu Lys Ile Val Leu Gly Ser Pro Leu Thr Pro Ser Ile 
            740                 745                 750         


Lys Asn Pro Met Ala Met Arg Ala Leu His Gln Leu Arg Lys Val Leu 
        755                 760                 765             


Asn Ala Leu Ile Leu Glu Gly Gln Ile Asp Glu Lys Thr Ile Ile His 
    770                 775                 780                 


Ile Glu Met Ala Arg Glu Leu Asn Asp Ala Asn Lys Arg Lys Gly Ile 
785                 790                 795                 800 


Gln Asp Tyr Gln Asn Asp Asn Lys Lys Phe Arg Glu Asp Ala Ile Lys 
                805                 810                 815     


Glu Ile Lys Lys Leu Tyr Phe Glu Asp Cys Lys Lys Glu Val Glu Pro 
            820                 825                 830         


Thr Glu Asp Asp Ile Leu Arg Tyr Gln Leu Trp Met Glu Gln Asn Arg 
        835                 840                 845             


Ser Glu Ile Tyr Glu Glu Gly Lys Asn Ile Ser Ile Cys Asp Ile Ile 
    850                 855                 860                 


Gly Ser Asn Pro Ala Tyr Asp Ile Glu His Thr Ile Pro Arg Ser Arg 
865                 870                 875                 880 


Ser Gln Asp Asn Ser Gln Met Asn Lys Thr Leu Cys Ser Gln Arg Phe 
                885                 890                 895     


Asn Arg Glu Val Lys Lys Gln Ser Met Pro Ile Glu Leu Asn Asn His 
            900                 905                 910         


Leu Glu Ile Leu Pro Arg Ile Ala His Trp Lys Glu Glu Ala Asp Asn 
        915                 920                 925             


Leu Thr Arg Glu Ile Glu Ile Ile Ser Arg Ser Ile Lys Ala Ala Ala 
    930                 935                 940                 


Thr Lys Glu Ile Lys Asp Lys Lys Ile Arg Arg Arg His Tyr Leu Thr 
945                 950                 955                 960 


Leu Lys Arg Asp Tyr Leu Gln Gly Lys Tyr Asp Arg Phe Ile Trp Glu 
                965                 970                 975     


Glu Pro Lys Val Gly Phe Lys Asn Ser Gln Ile Pro Asp Thr Gly Ile 
            980                 985                 990         


Ile Thr Lys Tyr Ala Gln Ala Tyr  Leu Lys Ser Tyr Phe  Lys Lys Val 
        995                 1000                 1005             


Glu Ser  Val Lys Gly Gly Met  Val Ala Glu Phe Arg  Lys Ile Trp 
    1010                 1015                 1020             


Gly Ile  Gln Glu Ser Phe Ile  Asp Glu Asn Gly Met  Lys His Tyr 
    1025                 1030                 1035             


Lys Val  Lys Asp Arg Ser Lys  His Thr His His Thr  Ile Asp Ala 
    1040                 1045                 1050             


Ile Thr  Ile Ala Cys Met Thr  Lys Glu Lys Tyr Asp  Val Leu Ala 
    1055                 1060                 1065             


His Ala  Trp Thr Leu Glu Asp  Gln Gln Asn Lys Lys  Glu Ala Arg 
    1070                 1075                 1080             


Ser Ile  Ile Glu Ala Ser Lys  Pro Trp Lys Thr Phe  Lys Glu Asp 
    1085                 1090                 1095             


Leu Leu  Lys Ile Glu Glu Glu  Ile Leu Val Ser His  Tyr Thr Pro 
    1100                 1105                 1110             


Asp Asn  Val Lys Lys Gln Ala  Lys Lys Ile Val Arg  Val Arg Gly 
    1115                 1120                 1125             


Lys Lys  Gln Phe Val Ala Glu  Val Glu Arg Asp Val  Asn Gly Lys 
    1130                 1135                 1140             


Ala Val  Pro Lys Lys Ala Ala  Ser Gly Lys Thr Ile  Tyr Lys Leu 
    1145                 1150                 1155             


Asp Gly  Glu Gly Lys Lys Leu  Pro Arg Leu Gln Gln  Gly Asp Thr 
    1160                 1165                 1170             


Ile Arg  Gly Ser Leu His Gln  Asp Ser Ile Tyr Gly  Ala Ile Lys 
    1175                 1180                 1185             


Asn Pro  Leu Asn Thr Asp Glu  Ile Lys Tyr Val Ile  Arg Lys Asp 
    1190                 1195                 1200             


Leu Glu  Ser Ile Lys Gly Ser  Asp Val Glu Ser Ile  Val Asp Glu 
    1205                 1210                 1215             


Val Val  Lys Glu Lys Ile Lys  Glu Ala Ile Ala Asn  Lys Val Leu 
    1220                 1225                 1230             


Leu Leu  Ser Ser Asn Ala Gln  Gln Lys Asn Lys Leu  Val Gly Thr 
    1235                 1240                 1245             


Val Trp  Met Asn Glu Glu Lys  Arg Ile Ala Ile Asn  Lys Val Arg 
    1250                 1255                 1260             


Ile Tyr  Ala Asn Ser Val Lys  Asn Pro Leu His Ile  Lys Glu His 
    1265                 1270                 1275             


Ser Leu  Leu Ser Lys Ser Lys  His Val His Lys Gln  Lys Val Tyr 
    1280                 1285                 1290             


Gly Gln  Asn Asp Glu Asn Tyr  Ala Met Ala Ile Tyr  Glu Leu Asp 
    1295                 1300                 1305             


Gly Lys  Arg Asp Phe Glu Leu  Ile Asn Ile Phe Asn  Leu Ala Lys 
    1310                 1315                 1320             


Leu Ile  Lys Gln Gly Gln Gly  Phe Tyr Pro Leu His  Lys Lys Lys 
    1325                 1330                 1335             


Glu Ile  Lys Gly Lys Ile Val  Phe Val Pro Ile Glu  Lys Arg Asn 
    1340                 1345                 1350             


Lys Arg  Asp Val Val Leu Lys  Arg Gly Gln Gln Val  Val Phe Tyr 
    1355                 1360                 1365             


Asp Lys  Glu Val Glu Asn Pro  Lys Asp Ile Ser Glu  Ile Val Asp 
    1370                 1375                 1380             


Phe Lys  Gly Arg Ile Tyr Ile  Ile Glu Gly Leu Ser  Ile Gln Arg 
    1385                 1390                 1395             


Ile Val  Arg Pro Ser Gly Lys  Val Asp Glu Tyr Gly  Val Ile Met 
    1400                 1405                 1410             


Leu Arg  Tyr Phe Lys Glu Ala  Arg Lys Ala Asp Asp  Ile Lys Gln 
    1415                 1420                 1425             


Asp Asn  Phe Lys Pro Asp Gly  Val Phe Lys Leu Gly  Glu Asn Lys 
    1430                 1435                 1440             


Pro Thr  Arg Lys Met Asn His  Asn Gln Phe Thr Ala  Phe Val Glu 
    1445                 1450                 1455             


Gly Ile  Asp Phe Lys Val Leu  Pro Ser Gly Lys Phe  Glu Lys Ile 
    1460                 1465                 1470             


<210> 222
<211> 1459
<212> PRT
<213> Flavobacterium columnare

<400> 222
Met Lys Phe Asn Leu Gly Leu Asp Ile Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Asn Glu Asp Tyr Glu Asn Lys Lys Gly Lys Ile Ile Ala 
            20                  25                  30          


Ala Gly Ser Arg Ile Ile Pro Met Thr Gln Asp Ile Leu Asp Lys Phe 
        35                  40                  45              


Gly Ser Gly Ala Ile Thr Glu Thr Gln Thr Ala Leu Arg Thr Asp Tyr 
    50                  55                  60                  


Arg Ser Lys Arg Lys Leu Ile Gln Arg Phe Leu Leu Arg Arg Glu Arg 
65                  70                  75                  80  


Leu His Arg Val Leu Asn Val Leu Asp Phe Leu Pro Lys His Tyr Ala 
                85                  90                  95      


Glu Ser Ile Asp Phe Glu Lys Tyr Phe Gly Lys Phe Leu Pro Asn Thr 
            100                 105                 110         


Glu Pro Lys Leu Ala Tyr Asn Gln Asn Gln Phe Ile Phe Gln Asn Ser 
        115                 120                 125             


Phe Leu Glu Met Leu Lys Glu Phe Gln Glu Lys His Pro Glu Leu Leu 
    130                 135                 140                 


Thr Asn Asn Lys Lys Ile Pro Tyr Asp Trp Thr Ile Tyr Tyr Leu Arg 
145                 150                 155                 160 


Lys Lys Ala Leu Asn Gln Arg Ile Glu Lys Glu Glu Leu Ala Trp Leu 
                165                 170                 175     


Leu Leu Gln Phe Asn Gln Lys Arg Gly Tyr Asn Gln Leu Arg Asp Glu 
            180                 185                 190         


Glu Glu Glu Ser Val Pro Asn Lys Gln Val Glu Phe Tyr Ser Leu Lys 
        195                 200                 205             


Ile Ile Asp Val Val Ala Asp Gln Pro Lys Glu Gly Arg Asp Lys Arg 
    210                 215                 220                 


Trp Tyr Ser Ile Asn Leu Glu Asn Gly Trp Thr Tyr Arg Arg Glu Ser 
225                 230                 235                 240 


Lys Thr Pro Leu Phe Asn Trp Glu Gly Lys Thr Lys Asp Phe Ile Val 
                245                 250                 255     


Thr Thr Asp Leu Asn Gln Asp Gly Ser Ile Lys Lys Asp Lys Glu Gly 
            260                 265                 270         


Lys Glu Lys Arg Ser Phe Arg Ala Pro Ser Glu Gly Asp Trp Thr Leu 
        275                 280                 285             


Leu Lys Lys Lys Thr Glu Lys Glu Ile Tyr Glu Ser Gly Lys Thr Leu 
    290                 295                 300                 


Gly Thr Tyr Ile Tyr Asp Ala Leu Leu Asn Thr Pro Asp Leu Lys Ile 
305                 310                 315                 320 


Lys Gly Asp Phe Ile Arg Thr Ile Asp Arg Ser Ile Tyr Lys Glu Glu 
                325                 330                 335     


Leu Gln Gln Ile Ile Asn Lys Gln Lys Glu Tyr His Leu Glu Leu Asn 
            340                 345                 350         


Ser Ser Lys Leu Tyr Lys Ala Cys Leu Glu Glu Leu Tyr Pro Lys Asn 
        355                 360                 365             


Glu Ile Tyr Lys Ser Ala Leu Lys Asn Lys Asp Ile Ala Tyr Leu Phe 
    370                 375                 380                 


Ile Asn Asp Ile Leu Tyr Tyr Gln Arg Pro Leu Lys Ala Pro Lys Tyr 
385                 390                 395                 400 


Asn Ile Gly Lys Cys Thr Tyr Glu Ser Arg Thr Phe Lys Lys Glu Asp 
                405                 410                 415     


Lys Lys Ile Arg Glu Tyr Ile Pro Ala Val Ala Lys Ser His Pro Leu 
            420                 425                 430         


Phe Gln Glu Phe Arg Leu Trp Gln Trp Ile Lys Asn Leu Lys Ile Tyr 
        435                 440                 445             


Glu Lys Leu Ser Ser Asp Asn Cys Thr Asp Phe Phe Leu Thr Asn Glu 
    450                 455                 460                 


Gln Asp Phe Glu Asn Leu Phe Glu Phe Leu Trp Asn Lys Lys Glu Ile 
465                 470                 475                 480 


Asp His Lys Gly Ile Leu Glu Tyr Leu Val Lys Thr Lys Phe Pro Asp 
                485                 490                 495     


Leu Lys Pro Lys Gln Val Lys Thr Lys Val Lys Glu Tyr Arg Trp Asn 
            500                 505                 510         


Tyr Val Tyr Asp His Glu Lys Asp Glu Ser Lys Thr Tyr Pro Cys Gly 
        515                 520                 525             


Glu Thr Tyr Phe Leu Leu Lys Asn Lys Leu Asp Lys Ile Tyr Asn Ala 
    530                 535                 540                 


Gln Asp Asp Phe Leu Asp Lys Glu Arg Leu Tyr Asn Leu Trp His Ile 
545                 550                 555                 560 


Ile Tyr Ser Val Thr Asp Lys Lys Gln Tyr Glu Lys Ala Leu Ala Lys 
                565                 570                 575     


Phe Ala Leu Lys Asn His Leu Asp Thr Lys Ser Phe Val Asn Thr Phe 
            580                 585                 590         


Lys Arg Ile Pro Pro Phe Lys Asn Asp Tyr Ala Ile Tyr Ser Leu Lys 
        595                 600                 605             


Ala Ile Lys Lys Leu Leu Pro Leu Met Arg Val Gly Lys Tyr Trp Asn 
    610                 615                 620                 


Tyr Asp Asp Ile Asp Pro Ile Thr Lys Gln Lys Ile Gln Cys Ile Ile 
625                 630                 635                 640 


Thr Gly Glu Glu Asn Asp Thr Ile Ser Thr Leu Val Arg Glu Lys Thr 
                645                 650                 655     


Asn His Phe Ser Asn Glu Asn Asp Phe Lys Asn Leu Pro Leu Trp Leu 
            660                 665                 670         


Ala Gly Tyr Ile Val Tyr Asn Ser His Asn Glu Ser Ser Glu Ile Glu 
        675                 680                 685             


Lys Trp Lys Ser Pro Gln Asp Ile Asp Thr Phe Leu Lys Lys Phe Lys 
    690                 695                 700                 


Gln His Ala Leu Arg Asn Pro Ile Val Glu Gln Val Val Thr Glu Thr 
705                 710                 715                 720 


Leu Arg Val Val Arg Asp Ile Trp Ser Lys Lys Gly Gln Gly Lys Lys 
                725                 730                 735     


Asp Phe Phe Asn Glu Ile His Ile Glu Leu Gly Lys Asp Leu Lys Asn 
            740                 745                 750         


Pro Val Asp Lys Arg Arg Lys Leu Ser Ser Thr Asn Thr Lys Asn Glu 
        755                 760                 765             


Ser Thr Asn Thr Arg Ile Lys Ala Leu Leu Ile Glu Leu Phe Thr Gln 
    770                 775                 780                 


Gly Val Glu Asn Val Lys Pro Asn Ser Pro Lys His Gln Glu Ile Leu 
785                 790                 795                 800 


Lys Ile Phe Glu Glu Gly Ala Leu Asn Ser Gly Ile Glu Ile Glu Glu 
                805                 810                 815     


Asp Ile Ile Lys Ile Ser Asn Thr Asp Gln Pro Thr Lys Lys Gln Leu 
            820                 825                 830         


Glu Leu Tyr Ile Leu Trp Leu Glu His Lys Tyr Lys Ser Pro Tyr Thr 
        835                 840                 845             


Gly Gln Ser Ile Pro Leu Ser Lys Leu Phe Thr Pro Asn Tyr Glu Ile 
    850                 855                 860                 


Glu His Ile Ile Pro Arg Ser Lys Tyr Tyr Asp Asp Asn Leu Ser Asn 
865                 870                 875                 880 


Lys Val Ile Cys Glu Thr Glu Ile Asn Arg Leu Lys Asn Asn Gln Leu 
                885                 890                 895     


Gly Tyr Glu Phe Ile Asn Asn His Glu Ile Arg Glu Val Thr Leu Glu 
            900                 905                 910         


Glu Gly Lys Thr Ile Arg Leu Leu Ser Pro Glu Gln Tyr Trp Asn Phe 
        915                 920                 925             


Val Thr Thr Tyr Tyr Ala Lys Asn Lys Ala Lys Arg Glu Asn Leu Leu 
    930                 935                 940                 


Leu Lys Glu Leu Pro Val Gln Met Val Glu Lys Gln Leu Asn Asp Thr 
945                 950                 955                 960 


Arg Tyr Val Ser Lys Tyr Val Met Gln Leu Leu Ser Lys Ile Val Arg 
                965                 970                 975     


Lys Glu Asp Gly Thr Asp Asn Gly Ile Asn Ser Thr Asn Ile Leu Ser 
            980                 985                 990         


Ile Ser Gly Lys Met Thr Arg Ala  Leu Lys Asn Asp Trp  Asp Leu Asn 
        995                 1000                 1005             


Asp Val  Trp Asn Asp Leu Leu  Leu Tyr Arg Phe Glu  Arg Leu Asn 
    1010                 1015                 1020             


Thr Ile  Thr Lys Thr Asn Leu  Phe Thr Thr Tyr Ser  Glu Gln Lys 
    1025                 1030                 1035             


Gln Lys  Arg Met Pro Ile Val  Pro Asp Gln Tyr Ala  Lys Gly Phe 
    1040                 1045                 1050             


His Lys  Lys Arg Leu Asp His  Arg His His Ala Leu  Asp Ala Ile 
    1055                 1060                 1065             


Val Ile  Ala Cys Ile Thr Arg  Asn His Ile Asn Tyr  Met Asn Asn 
    1070                 1075                 1080             


Gln Asn  Ile Gln Gly Glu Lys  Leu Lys Lys Asn Ala  Ile Glu Lys 
    1085                 1090                 1095             


Glu Asn  Tyr Arg Glu Ile Leu  Gln Lys Ser Arg Leu  Asp Ile Arg 
    1100                 1105                 1110             


Ala Gln  Leu Cys Glu Lys Lys  Tyr Asn Asp Asn Asp  Pro Thr Lys 
    1115                 1120                 1125             


Tyr Asn  Trp Val Phe Ile Lys  Pro Trp Ala Asp Phe  Thr Glu Asn 
    1130                 1135                 1140             


Thr Lys  Asp Ile Leu Glu Ser  Ile Ile Pro Ser Phe  Lys Gln Asn 
    1145                 1150                 1155             


Leu Arg  Ile Ile Asn Lys Thr  Val Asn Tyr Tyr Glu  Lys Tyr Asn 
    1160                 1165                 1170             


Glu Asn  Gly Lys Lys Val Lys  Val Arg Gln Ile Lys  Gly Asp Asn 
    1175                 1180                 1185             


Trp Ala  Ile Arg Lys Pro Leu  His Lys Glu Thr Ile  Ser Gly Lys 
    1190                 1195                 1200             


Val His  Leu Ser Tyr Lys Thr  Pro Ala Lys Gly Lys  Ile Leu Thr 
    1205                 1210                 1215             


Ala Thr  Arg Lys Val Leu Asp  Ser Ser Met Asp Phe  Lys Ser Ile 
    1220                 1225                 1230             


Glu Lys  Ile Thr Asp Thr Gly  Ile Gln Lys Ile Leu  Lys Asn Tyr 
    1235                 1240                 1245             


Leu Glu  Tyr Lys Lys Ser Pro  Glu Leu Ala Phe Ser  Pro Glu Gly 
    1250                 1255                 1260             


Ile Glu  Glu Leu Asn Ala Thr  Ile Thr Lys Tyr Asn  Asn Gly Phe 
    1265                 1270                 1275             


His His  Lys Pro Ile Tyr Lys  Val Arg Ile Tyr Glu  Glu Gly Val 
    1280                 1285                 1290             


Lys Phe  Pro Leu Gly Asn Lys  Gly Asn Lys Lys Ser  Lys Tyr Val 
    1295                 1300                 1305             


Glu Ala  Glu Lys Gly Thr Asn  Leu Phe Phe Ala Ile  Tyr Lys Asp 
    1310                 1315                 1320             


Gln Glu  Asn Asn Arg Tyr Phe  Glu Thr Ile Pro Phe  Asn Asp Val 
    1325                 1330                 1335             


Leu Glu  Thr Leu Lys Lys Gly  Met Ser Ala Val Pro  Glu Lys Asn 
    1340                 1345                 1350             


Gln Glu  Glu Asn Thr Leu Val  Phe Ala Leu Ser Pro  Gln Asp Leu 
    1355                 1360                 1365             


Val Phe  Val Pro Thr Leu Asp  Glu Ile Glu Asn Pro  Asp Ile Val 
    1370                 1375                 1380             


Asp Phe  Lys Asn Leu Thr Lys  Asp Gln Thr Asn Arg  Ile Tyr Lys 
    1385                 1390                 1395             


Met Val  Ser Ser Ser Gly Lys  Gln Cys Phe Phe Ile  Lys Ala Glu 
    1400                 1405                 1410             


Val Ala  Thr Ser Ile Val Asn  Lys Met Glu Phe Ser  Thr Ser Asn 
    1415                 1420                 1425             


Lys Met  Glu Asn Ser Ile Glu  Gly Ile Gln Ile Lys  Ser Asn Cys 
    1430                 1435                 1440             


Trp Lys  Leu Lys Leu Asp Arg  Leu Gly Thr Ile Thr  Arg Val Ile 
    1445                 1450                 1455             


Lys 
    


<210> 223
<211> 1535
<212> PRT
<213> Flavobacterium columnare

<400> 223
Met Thr Lys Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Ile Arg Asp Thr Glu Asn Glu Gly Ile Asn Gln Ile Leu Asp Lys 
            20                  25                  30          


Gly Ala Arg Ile Phe Ser Glu Gly Val Lys Ser Glu Asn Gly Lys Glu 
        35                  40                  45              


Ile Ser Arg Ala Ala Glu Arg Thr Ala Tyr Arg Ser Ala Arg Lys Ile 
    50                  55                  60                  


Lys Tyr Arg Arg Lys Leu Arg Lys Tyr Glu Thr Leu Lys Val Leu Ser 
65                  70                  75                  80  


Ile Asn Gly Met Cys Pro Leu Ser Val Glu Glu Val Glu Gln Trp Lys 
                85                  90                  95      


Lys Ser Gly Phe Lys Glu Tyr Pro Leu Asn Pro Glu Phe Leu Asp Trp 
            100                 105                 110         


Leu Arg Thr Asn Glu Asp Lys Asn Ile Asn Pro Tyr Leu Phe Arg Asp 
        115                 120                 125             


Lys Ala Ser Lys Gln Lys Val Thr Leu Phe Glu Leu Gly Arg Ala Leu 
    130                 135                 140                 


Tyr His Ile Ala Gln Arg Arg Gly Phe Leu Ser Asn Arg Leu Asp Gln 
145                 150                 155                 160 


Ser Ala Glu Gly Val Phe Glu Glu His Asn Pro Gln Ile Gln Asn Leu 
                165                 170                 175     


Ile Glu Asp Leu Asp Ser Ser Asn Thr Ile Leu Asn Glu Leu Lys Glu 
            180                 185                 190         


Tyr Tyr Ile Asn Leu Gly Ile Ile Asp Glu Thr Glu Lys Ser Gly Phe 
        195                 200                 205             


Lys Lys Asp Leu Asp Glu Gly Glu Lys Lys Leu Lys Ser Leu Tyr Asn 
    210                 215                 220                 


Ser Leu Val Ala Ile Thr Lys Lys Asn Ala Asn Asp Ile Glu Thr Cys 
225                 230                 235                 240 


Lys Gln Glu Leu Ile Ala Arg Leu Asn Lys Lys Glu Asp Leu Gly Lys 
                245                 250                 255     


Val Lys Gly Lys Ile Lys Asp Ile Ser Gln Ala Met Leu Asp Arg Asn 
            260                 265                 270         


Phe Lys Thr Leu Gly Gln Tyr Phe Phe Ser Leu Tyr Asn Lys Glu Arg 
        275                 280                 285             


Ile Arg Asn Gln Tyr Thr Ser Arg Glu Glu His Tyr Leu Glu Glu Phe 
    290                 295                 300                 


Ile Ile Ile Cys Gln Thr Gln Gly Ile Glu Gly Ile Asn Thr Asn Glu 
305                 310                 315                 320 


Lys Leu Pro Glu Lys Lys Phe Thr Gly Leu Ala Lys Asp Leu Tyr Arg 
                325                 330                 335     


Ala Ile Phe Phe Gln Arg Pro Leu Lys Ser Gln Lys Gly Leu Ile Gly 
            340                 345                 350         


Lys Cys Ser Phe Glu Lys Asn Lys Ser Arg Cys Ala Val Ser His Pro 
        355                 360                 365             


Asp Tyr Glu Glu Phe Arg Met Trp Ser Tyr Leu Asn Thr Ile Lys Ile 
    370                 375                 380                 


Gly Thr Gln Ser Glu Lys Thr Leu Arg Phe Leu Thr Leu Glu Glu Lys 
385                 390                 395                 400 


Leu Lys Leu Val Pro Lys Phe Tyr Arg Lys Ser Asp Phe Asn Phe Glu 
                405                 410                 415     


Val Leu Ala Lys Glu Leu Val Glu Lys Gly Ala Ser Phe Gly Tyr Tyr 
            420                 425                 430         


Lys Ser Ser Lys Lys Asn Glu Phe Phe Tyr Trp Phe Asn Tyr Lys Pro 
        435                 440                 445             


Thr Asp Ser Val Ser Ala Cys Val Val Ser Ala Ser Leu Glu Asn Ala 
    450                 455                 460                 


Ile Gly Lys Asp Trp Lys Ile Lys Thr Phe Glu Tyr Gln Thr Arg Asn 
465                 470                 475                 480 


Thr Glu Lys Asn Glu Val Thr Lys Ser Val Asp Tyr Lys Asp Leu Trp 
                485                 490                 495     


His Leu Leu Ser Val Ala Thr Ser Asp Thr Tyr Leu Tyr Asp Phe Ala 
            500                 505                 510         


Ile Glu Lys Leu Lys Leu Glu Pro Lys Asn Ala Lys Ala Phe Ser Lys 
        515                 520                 525             


Thr Lys Leu Lys Lys Asp Phe Ala Ser Leu Ser Leu Ala Ala Ile Ala 
    530                 535                 540                 


Lys Ile Leu Pro Tyr Leu Lys Gln Gly Leu Leu Tyr Ser His Ala Val 
545                 550                 555                 560 


Phe Met Ala Asn Ile Glu Asn Ile Val Asp Ala Asp Ile Trp Lys Asp 
                565                 570                 575     


Glu Glu Gln Gln Lys Phe Ile Gln Ser Lys Ile Val Glu Leu Val Asp 
            580                 585                 590         


Asn Tyr Ile Val Glu Lys Ser Lys Leu Glu Leu Ile Asn Gly Leu Leu 
        595                 600                 605             


Lys Ile Tyr Asn Thr Glu Asp Lys Glu Gly Arg Lys Val Tyr Tyr Ser 
    610                 615                 620                 


Lys Glu Ala Glu Ser Leu Phe Glu Ala Asp Leu Arg Lys Lys Leu Val 
625                 630                 635                 640 


Pro Phe Tyr Lys Ala Asn Ile Ile Ile Glu Glu His Glu Gln Glu Ile 
                645                 650                 655     


Ile Phe Gln Asp Leu Phe Pro Ile Leu Met Asp Gln Leu Lys Lys Gln 
            660                 665                 670         


Glu Phe Ile Lys Ile Gly Arg Leu Asp Lys Gln Ile Glu Ala Phe Leu 
        675                 680                 685             


Glu Gly Glu Asn Glu Glu Gly Gln Ile Phe Cys Asn His Thr Asp Lys 
    690                 695                 700                 


Leu Lys Lys Leu Tyr His Pro Ser Asp Ile Glu Val Phe Lys Lys Lys 
705                 710                 715                 720 


Thr Ile Lys Asp Glu Trp Gly Asn Glu Lys Val Val Leu Gly Ser Pro 
                725                 730                 735     


Leu Thr Thr Ser Ile Lys Asn Pro Met Ala Met Arg Ala Leu His Gln 
            740                 745                 750         


Leu Arg Lys Val Leu Asn Thr Leu Ile Ala Asn Asp Gln Ile Asp Glu 
        755                 760                 765             


Asp Thr Arg Ile His Ile Glu Met Ala Arg Glu Leu Asn Asp Ala Asn 
    770                 775                 780                 


Lys Arg Lys Gly Ile Gln Asp Phe Gln Asn Glu Asn Lys Lys Phe Arg 
785                 790                 795                 800 


Glu Glu Ala Ile Lys Glu Ile Lys Lys Leu Tyr Leu Glu Glu Cys His 
                805                 810                 815     


Lys Asp Val Asn Pro Thr Glu Asp Asp Ile Leu Arg Tyr Gln Leu Trp 
            820                 825                 830         


Leu Glu Gln Gly Lys Cys Glu Ile Tyr Glu Glu Gly Asn Asn Ile Ser 
        835                 840                 845             


Ile Cys Asp Ile Ile Gly Ser Asn Pro Ser Tyr Asp Ile Glu His Thr 
    850                 855                 860                 


Ile Pro Arg Ser Ile Ser Gln Asp Asn Ser Gln Met Asn Lys Thr Leu 
865                 870                 875                 880 


Cys Ser Leu Lys Phe Asn Arg Ser Ile Lys Lys Gln Lys Met Pro Val 
                885                 890                 895     


Glu Leu Ser Asn Tyr Asn Asp Ile Leu Pro Arg Ile Ala His Trp Lys 
            900                 905                 910         


Lys Glu Ala Glu Glu Leu Thr Arg Gln Ile Glu Thr Ile Ser Arg Ser 
        915                 920                 925             


Ile Lys Ser Ala Ala Thr Lys Val Ala Lys Asp Lys Asn Ile Arg Lys 
    930                 935                 940                 


Arg His Tyr Leu Thr Leu Lys Arg Asp Tyr Ile Leu Gly Lys Tyr Glu 
945                 950                 955                 960 


Arg Phe Thr Trp Glu Glu Pro Lys Val Gly Phe Lys Asn Ser Gln Ile 
                965                 970                 975     


Pro Asp Thr Gly Ile Ile Thr Lys Tyr Ala Gln Ala Tyr Leu Lys Ser 
            980                 985                 990         


Tyr Phe Lys Arg Val Glu Ser Val  Lys Gly Gly Ala Val  Ala Glu Phe 
        995                 1000                 1005             


Arg Lys  Leu Trp Gly Ile Gln  Glu Ser Phe Ile Asp  Glu Asn Trp 
    1010                 1015                 1020             


Trp Lys  His Tyr Lys Asp Lys  Asp Arg Asp Lys His  Thr His His 
    1025                 1030                 1035             


Thr Ile  Asp Ala Ile Thr Ile  Ala Cys Met Pro Lys  Asp Lys Tyr 
    1040                 1045                 1050             


Asp Leu  Leu Ala His Ala Trp  Arg Leu Glu Asp Glu  Gln Asp Lys 
    1055                 1060                 1065             


Lys Ala  Ala Lys Val Leu Ile  Glu Gln Ala Lys Pro  Trp Lys Thr 
    1070                 1075                 1080             


Phe Lys  Glu Asp Ile Glu Lys  Ile Glu Thr Glu Ile  Leu Val Ser 
    1085                 1090                 1095             


His Phe  Thr Pro Asp Asn Val  Lys Lys Gln Ser Lys  Ser Ile Ile 
    1100                 1105                 1110             


Lys Asn  Arg Gly Lys Lys Val  Tyr Val Leu Lys Asn  Glu Leu Pro 
    1115                 1120                 1125             


Val Asn  Phe Lys Asn Lys Ile  Glu Gly Lys Asp Tyr  Phe Lys Leu 
    1130                 1135                 1140             


Lys Phe  Asp Ser Lys Ile Leu  Tyr Lys Ile Pro Lys  Lys Lys Glu 
    1145                 1150                 1155             


Lys Gln  Thr Asp Thr Phe Tyr  Glu Glu Leu Pro Lys  Asn Tyr Leu 
    1160                 1165                 1170             


Asn Gly  Val Glu Gly Lys Asp  Tyr Phe Lys Ile Asn  Thr Thr Gly 
    1175                 1180                 1185             


Lys Thr  Phe Tyr Lys Ile Pro  Ile Phe Asn Gln Gly  Asp Thr Ile 
    1190                 1195                 1200             


Arg Gly  Ser Leu His Gln Glu  Thr Thr Tyr Gly Ala  Ile Lys Leu 
    1205                 1210                 1215             


Pro Asp  Ile Asp Ile Glu Thr  Lys Lys Pro Leu His  Thr Asp Lys 
    1220                 1225                 1230             


Gly Gly  Phe Ile Leu Lys Lys  Asp Ile Lys Gly Asn  Glu Ile Val 
    1235                 1240                 1245             


Phe Phe  Val Val Arg Lys Glu  Ile Ser Lys Ile Ser  Glu Asn Asp 
    1250                 1255                 1260             


Val Gln  Asn Ile Val Asp Asn  Val Val Arg Lys Lys  Ile Glu Asn 
    1265                 1270                 1275             


Ala Ile  Ala Asn Ser Leu Ile  Thr Phe Lys Ile Val  Lys Lys Lys 
    1280                 1285                 1290             


Lys Val  Ala Val Ile Lys Glu  Gly Val Thr Ile Trp  Met Arg Glu 
    1295                 1300                 1305             


Pro Asn  Ile Glu Lys Gly Ile  Glu Gly Ile Pro Ile  Lys Lys Val 
    1310                 1315                 1320             


Arg Ile  Ile Thr Asn Ser Val  Lys Asn Pro Ile Glu  Ile Lys Val 
    1325                 1330                 1335             


His Ser  Pro Leu Ser Lys Ser  Arg His Lys His Lys  Gln Lys Val 
    1340                 1345                 1350             


Tyr Gly  Gln Asn Asp Glu Asn  Tyr Ala Met Ala Leu  Tyr Glu Leu 
    1355                 1360                 1365             


Asp Gly  Lys Arg Glu Phe Glu  Leu Ile Asn Asn Phe  Asn Leu Ala 
    1370                 1375                 1380             


Lys Leu  Leu Lys Gln Ser Gln  Ser Tyr Tyr Pro Leu  His Lys Glu 
    1385                 1390                 1395             


Lys Glu  Ile Lys Gly Lys Lys  Ile Leu Val Pro Ile  Glu Lys Arg 
    1400                 1405                 1410             


Asn Asn  Lys Asp Val Ile Leu  Lys Arg Gly Gln Gln  Val Val Phe 
    1415                 1420                 1425             


Tyr Asp  Lys Thr Val Glu Asn  Pro Lys Asp Ile Ser  Glu Ile Ile 
    1430                 1435                 1440             


Asp Phe  Arg Glu Arg Ile Tyr  Ile Ile Glu Gly Leu  Thr Ile Gln 
    1445                 1450                 1455             


Arg Gln  Lys Asp Lys Lys Thr  Ser Lys Val Asn Glu  Tyr Gly Ile 
    1460                 1465                 1470             


Ile Gln  Leu Arg His Phe Lys  Glu Ala Arg Lys Ser  Glu Glu Ile 
    1475                 1480                 1485             


Ser Lys  Asp Asn Phe Lys Pro  Asp Gly Glu Phe Lys  Ile Asn Glu 
    1490                 1495                 1500             


Asn Lys  Pro Thr Arg Lys Met  Asn His Asn Gln Phe  Thr Ala Phe 
    1505                 1510                 1515             


Val Glu  Gly Ile Asp Phe Lys  Val Leu Pro Ser Gly  Lys Phe Gln 
    1520                 1525                 1530             


Lys Ile  
    1535 


<210> 224
<211> 1354
<212> PRT
<213> Flavobacterium psychrophilum


<220>
<223> Flavobacterium psychrophilum JIP02/86

<400> 224
Met Lys Lys Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ile Asn Glu Ala Glu Asn Glu Ile Glu Val Ser Ser Ile Val 
            20                  25                  30          


Asn Thr Gly Val Arg Ile Val Pro Leu Thr Thr Asp Glu Glu Ser Asp 
        35                  40                  45              


Phe Lys Lys Gly Asn Thr Ile Ser Ile Asn Ala Asp Arg Thr Leu Lys 
    50                  55                  60                  


Arg Gly Ala Arg Arg Gly Leu Gln Arg Phe Lys Gln Arg Arg Glu Ala 
65                  70                  75                  80  


Leu Leu Glu Thr Phe Asn Arg Ile Lys Phe Ile Ala Thr Asp Phe Val 
                85                  90                  95      


Tyr Ala Glu Thr Gly Ala Ala Thr Thr Phe Ser Ser Tyr Gln Leu Arg 
            100                 105                 110         


Ala Lys Ser Ala Val Glu Ala Val Thr Lys Glu Glu Leu Val Lys Val 
        115                 120                 125             


Leu Leu Met Leu Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala 
    130                 135                 140                 


Lys Thr Ala Glu Glu Gly Asp Ala Ile Asp Gly Met Lys Ile Ala Lys 
145                 150                 155                 160 


Glu Ile Phe Glu Asn Asn Leu Thr Pro Gly Gln Trp Val Tyr Asn Ser 
                165                 170                 175     


Leu Ser Lys Gly Gly Lys Phe Ile Pro Asp Phe Tyr His Ser Asp Leu 
            180                 185                 190         


Gln Lys Glu Leu Glu Lys Ile Val Arg Phe Gln Asn Gln Phe His Ser 
        195                 200                 205             


Glu Gln Ile Asn Asp Lys Leu Leu Ala Asp Ile Gln Gly Lys Ser Arg 
    210                 215                 220                 


Thr Gln Thr Ser Gln His Phe Ser Lys Thr Leu Asn Ile Pro Leu Ala 
225                 230                 235                 240 


Glu Asn Lys Gly Thr Arg Glu Glu Thr Lys Leu Gln His Tyr Gln Trp 
                245                 250                 255     


Arg Asn Glu Ala Leu Ala Asn Glu Leu Asp Met Lys Ile Leu Ala Phe 
            260                 265                 270         


Ile Ile Thr Glu Ile Asn Asn Gln Ile Asn Gln Ser Ser Gly Tyr Leu 
        275                 280                 285             


Gly Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Gln Glu Thr 
    290                 295                 300                 


Val Gly Gln Tyr Gln Tyr Lys Gln Leu Gln Glu Asn Val His Ala Lys 
305                 310                 315                 320 


Leu Lys Asn Gln Val Phe Tyr Arg Gln Asp Tyr Leu Asp Glu Phe Glu 
                325                 330                 335     


Lys Ile Trp Glu Thr Gln Ala Lys Phe His Ser Glu Leu Asn Glu Lys 
            340                 345                 350         


Leu Lys Ala Glu Ile Arg Asp Ile Thr Ile Phe Tyr Gln Arg Lys Leu 
        355                 360                 365             


Lys Ser Gln Lys His Leu Val Ser Phe Cys Glu Phe Glu Lys Gly His 
    370                 375                 380                 


Lys Ala Ile Pro Lys Ser Ser Pro Leu Phe Gln Glu Phe Arg Ile Trp 
385                 390                 395                 400 


Gln Asn Leu Asn Asn Val Val Val Lys Asn Glu Thr Thr Lys Glu Val 
                405                 410                 415     


Phe Glu Leu Ser Glu Glu Leu Lys Gln Leu Ile Ala Glu Glu Leu Gln 
            420                 425                 430         


Phe Lys Glu Ser Met Thr Asp Val Gln Met Leu Thr Phe Cys Glu Leu 
        435                 440                 445             


Lys Lys Gly Thr His Thr Val Asn Phe Lys Lys Ile Glu Gly Asn Arg 
    450                 455                 460                 


Thr Asn Thr Ser Ile Tyr Lys Ala Phe Glu Lys Ile Leu Glu Val Glu 
465                 470                 475                 480 


Gly Tyr Glu Ile Asp Phe Ser Lys Met Lys Pro Leu Glu Ile Lys Glu 
                485                 490                 495     


Thr Val Ala Pro Ile Phe Glu Thr Leu Asn Ile Asn Thr Val Ile Leu 
            500                 505                 510         


Asp Phe Asp Pro Thr Ile Gln Gly Asn Asp Phe Asp Lys Gln Pro Tyr 
        515                 520                 525             


Tyr Gln Leu Trp His Leu Leu Tyr Ser Ala Glu Asp Asp Asp Lys Leu 
    530                 535                 540                 


Lys Glu Thr Leu Lys Thr Lys Phe Gly Phe Lys Glu Asn His Leu Pro 
545                 550                 555                 560 


Phe Ile Leu Asn Ile Asn Leu Gln Ala Asp Tyr Gly Ser Leu Ser Ala 
                565                 570                 575     


Lys Ala Ile Lys Lys Ile Leu Pro His Leu Met Asp Gly His Ile Tyr 
            580                 585                 590         


Asp Lys Ala Cys Leu Met Val Gly Tyr Asn His Ser Ser Ser Leu Thr 
        595                 600                 605             


Thr Ala Gln Asn Asn Asp Arg Val Leu Lys Asp Thr Leu Glu Leu Leu 
    610                 615                 620                 


Lys Lys Asn Ser Leu Arg Asn Pro Val Val Glu Lys Ile Leu Asn Gln 
625                 630                 635                 640 


Met Ile Asn Val Ile Asn Ala Ile Met Lys Asp Pro Ala Met Gly Lys 
                645                 650                 655     


Pro Asp Glu Ile Arg Val Glu Leu Ala Arg Glu Leu Lys Ala Asn Asn 
            660                 665                 670         


Glu Gln Arg Lys Lys Ala Thr Ser Asp Ile Asn Thr Ala Thr Thr Glu 
        675                 680                 685             


His Glu Arg Ile Arg Lys Leu Leu His Ser Glu Phe Asn Ile Pro Arg 
    690                 695                 700                 


Val Thr Arg Asn Asp Ile Ile Arg Tyr Lys Leu Trp Leu Glu Thr Gly 
705                 710                 715                 720 


Gly Ile Ser Leu Tyr Thr Gly Asn Pro Ile Lys Ala Ser Asp Leu Phe 
                725                 730                 735     


Ser Lys Asn Tyr Asp Ile Glu His Ile Ile Pro Lys Ser Arg Leu Phe 
            740                 745                 750         


Asp Asp Ser Phe Ser Asn Lys Thr Leu Cys Glu Arg Gln Leu Asn Ile 
        755                 760                 765             


Asp Lys Ser Asn Lys Thr Ala Tyr Ser Phe Leu Gln Glu Lys Leu Ser 
    770                 775                 780                 


Glu Asn Asp Phe Ala Ala Tyr Glu Asn Arg Val Lys Asp Leu Phe Lys 
785                 790                 795                 800 


Thr Gly Lys Ile Lys Ser Tyr Thr Lys Tyr Lys Lys Leu Leu Met Ala 
                805                 810                 815     


Asp Asn Glu Ile Pro Glu Gly Phe Ile Asp Arg Gln Leu Arg Glu Thr 
            820                 825                 830         


Gln Tyr Ile Ala Lys Lys Ala Lys Glu Ile Leu Leu Glu Val Ser Arg 
        835                 840                 845             


Asn Val Thr Ala Thr Ile Gly Ser Val Thr Asp Lys Leu Arg Gln Asp 
    850                 855                 860                 


Trp Glu Leu Val Asp Val Met Lys Glu Leu Asn Trp Glu Lys Tyr Asp 
865                 870                 875                 880 


Lys Leu Gly Leu Thr His Ile Glu Glu Gly Lys Asn Gly Glu Arg Leu 
                885                 890                 895     


Ser Lys Ile Lys Asp Trp Thr Lys Arg Asn Asp His Arg His His Ala 
            900                 905                 910         


Met Asp Ala Ile Thr Val Ala Phe Thr Lys Pro Ala Tyr Ile Gln Tyr 
        915                 920                 925             


Leu Asn Asn Leu Asn Ala Lys Thr Gln Gly Glu Asn Lys Ala Asn Ser 
    930                 935                 940                 


Ile Ile Gly Ile Glu Asn Lys His Leu Tyr Arg Asp Lys Asn Asn Lys 
945                 950                 955                 960 


Leu Arg Phe Ile Ser Pro Met Lys Asn Phe Arg Glu Glu Ala Lys Lys 
                965                 970                 975     


Gln Leu Glu Ser Ile Leu Ile Ser Tyr Lys Ala Lys Asn Lys Val Val 
            980                 985                 990         


Thr Lys Asn Lys Asn Thr Thr Lys  Lys Ser Gly Gly Thr  Asn Gln Lys 
        995                 1000                 1005             


Ile Gln  Leu Thr Pro Arg Gly  Arg Leu His Lys Glu  Thr Val Tyr 
    1010                 1015                 1020             


Gly Lys  Leu Gln Gln Tyr Ala  Thr Lys Glu Glu Lys  Val Asn Ala 
    1025                 1030                 1035             


Ser Phe  Thr Glu Asp Tyr Ile  Gln Lys Val Ala Lys  Lys Glu Tyr 
    1040                 1045                 1050             


Arg Glu  Ala Leu Leu Lys Arg  Leu Glu Glu Asn Asp  Asn Asp Pro 
    1055                 1060                 1065             


Lys Lys  Ala Phe Thr Gly Lys  Asn Ala Leu Asn Lys  Thr Pro Ile 
    1070                 1075                 1080             


Tyr Ile  Ser Leu Lys Asp Asn  Ile Ile Val Pro Glu  Lys Val Lys 
    1085                 1090                 1095             


Thr Val  Trp Leu Glu Thr Asp  Tyr Thr Ile Arg Lys  Asp Ile Thr 
    1100                 1105                 1110             


Pro Asp  Leu Lys Ile Asp Lys  Val Ile Asp Val Gly  Ile Lys Arg 
    1115                 1120                 1125             


Ile Leu  Gln Asn Arg Leu Asn  Glu Phe Asn Gly Asp  Pro Lys Lys 
    1130                 1135                 1140             


Ala Phe  Val Asn Leu Gly Glu  Ser Pro Ile Trp Leu  Asn Lys Glu 
    1145                 1150                 1155             


Lys Gly  Ile Ala Ile Lys Arg  Val Thr Ile Ser Gly  Val Ser Asn 
    1160                 1165                 1170             


Ala Gln  Ala Leu His Thr Lys  Lys Asp His Leu Gly  Asn Glu Ile 
    1175                 1180                 1185             


Leu Asp  Lys Asn Gly Asn Pro  Ile Pro Val Asp Phe  Ile Ser Thr 
    1190                 1195                 1200             


Gly Asn  Asn His His Val Ala  Ile Tyr Arg Asp Glu  Lys Gly Asn 
    1205                 1210                 1215             


Leu Gln  Glu Glu Val Val Ser  Phe Tyr Asp Ala Val  Ile Arg Arg 
    1220                 1225                 1230             


Asn Leu  Gly Leu Ser Val Ile  Asn Lys Asn His Glu  Lys Gly Trp 
    1235                 1240                 1245             


Glu Phe  Leu Phe Ser Met Lys  Gln Asn Glu Phe Phe  Ile Phe Pro 
    1250                 1255                 1260             


Ser Asp  Gly Phe Asn Pro His  Glu Ile Asp Leu Leu  Asn Pro Asn 
    1265                 1270                 1275             


Asn Tyr  His Leu Ile Ser Pro  Asn Ile Phe Arg Val  Gln Lys Ile 
    1280                 1285                 1290             


Ser Thr  Lys Asn Tyr Met Phe  Asn His His Leu Glu  Thr Lys Ala 
    1295                 1300                 1305             


Val Asp  Gly Glu Met Leu Lys  Ser Lys Lys Glu Leu  Ser Lys Thr 
    1310                 1315                 1320             


Ser Tyr  His Phe Ile Gln Thr  Pro Thr Asn Leu Asn  Gly Ile Ile 
    1325                 1330                 1335             


Lys Val  Arg Ile Asn His Leu  Gly Lys Ile Val His  Leu Gly Glu 
    1340                 1345                 1350             


Tyr 
    


<210> 225
<211> 1458
<212> PRT
<213> Fluviicola taffensis

<400> 225
Met Thr Lys Thr Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly 
1               5                   10                  15      


Trp Ala Leu Ile Asn Gln Asp Phe Asp Asn Lys Lys Gly Glu Ile Leu 
            20                  25                  30          


Gly Met Gly Ser Arg Ile Ile Pro Met Thr Gln Asp Ile Lys Asp Glu 
        35                  40                  45              


Phe Gly Lys Gly Asn Ser Ile Ser Gln Thr Ala Glu Arg Thr Arg Leu 
    50                  55                  60                  


Arg Gly Val Arg Arg Leu Ile His Arg Thr Leu Leu Arg Arg Glu Arg 
65                  70                  75                  80  


Leu His Arg Val Leu Asn Ile Ile Gly Phe Leu Pro Glu His Tyr Ala 
                85                  90                  95      


Asn Gln Ile Asp Phe Glu Lys Arg Phe Gly Lys Phe Lys Pro Glu Ser 
            100                 105                 110         


Glu Pro Lys Ile Ser Phe Asp Gly Asn Asp Val Phe Leu Phe Glu Lys 
        115                 120                 125             


Ser Tyr Gln Glu Met Leu Val Asp Phe Lys Ile His Gln Pro Gln Leu 
    130                 135                 140                 


Val Ser Asn Gly Lys Lys Ile Pro His Asp Trp Thr Ile Tyr Tyr Leu 
145                 150                 155                 160 


Arg Lys Lys Ala Leu Ser Lys Lys Ile Glu Lys Glu Glu Leu Ala Trp 
                165                 170                 175     


Ile Leu Leu Asn Phe Asn Gln Lys Arg Gly Tyr Tyr Gln Leu Arg Gly 
            180                 185                 190         


Glu Glu Glu Glu Glu Thr Pro Asn Lys Leu Val Glu Phe His Ser Leu 
        195                 200                 205             


Lys Ile Val Glu Val Asn Ala Asp Glu Pro Gln Lys Gly Lys Pro Glu 
    210                 215                 220                 


Ile Trp Tyr Ser Leu Val Leu Glu Asn Gly Trp Val Tyr Arg Arg Ala 
225                 230                 235                 240 


Ser Lys Thr Pro Leu Phe Asp Trp Lys Asp Lys Ile Arg Glu Phe Ile 
                245                 250                 255     


Val Thr Thr Glu Ile Asn Asn Asp Gly Thr Val Lys Thr Asp Lys Glu 
            260                 265                 270         


Gly Thr Glu Lys Arg Ser Phe Arg Ala Pro Lys Pro Glu Asp Trp Thr 
        275                 280                 285             


Leu Gln Lys Lys Lys Thr Glu Phe Glu Leu Ser Lys Ser Gly Asn Glu 
    290                 295                 300                 


Val Gly Ala Phe Ile Tyr Glu Ser Ile Leu Gln Lys Pro Asn Gln Lys 
305                 310                 315                 320 


Ile Arg Gly Lys Leu Ile Ser Thr Ile Glu Arg Lys Phe Tyr Lys Glu 
                325                 330                 335     


Glu Leu Lys Thr Ile Leu Lys Thr Gln Leu Phe Phe His Lys Glu Leu 
            340                 345                 350         


Lys Asp Glu Lys Leu Tyr Asn Ala Cys Ile Glu Glu Leu Tyr Lys Asn 
        355                 360                 365             


Asn Glu Ala His Arg Ser Leu Leu Ser Asn Lys Gly Phe Glu His Leu 
    370                 375                 380                 


Phe Ile Asn Asp Ile Leu Phe Tyr Gln Arg Pro Leu Arg Ser Lys Lys 
385                 390                 395                 400 


Ser Gln Ile Ser Asn Cys Pro Leu Glu Lys Arg Thr Tyr Lys Lys Glu 
                405                 410                 415     


Gly Ile Glu Ile Thr Glu Gly Ile Lys Val Ile Ser Lys Ser Asn Pro 
            420                 425                 430         


Ile Tyr Gln Glu Phe Arg Leu Trp Gln Trp Ile Ser Asn Leu Ser Leu 
        435                 440                 445             


Tyr Cys Ile Glu Pro Thr Glu Thr Asn Val Thr Ser Thr Phe Leu Asn 
    450                 455                 460                 


Ser Ile Glu Asp Tyr Glu Asn Leu Phe Glu Phe Leu Asn Asn Arg Lys 
465                 470                 475                 480 


Glu Ile Glu Gln Lys His Leu Leu Lys Tyr Leu Leu Glu Asn Gln Gly 
                485                 490                 495     


Phe Lys Gly Lys Leu Leu Thr Asn Glu Leu Glu Lys Phe Arg Trp Asn 
            500                 505                 510         


Phe Val Ala Asp Lys Lys Tyr Pro Cys Asn Glu Thr Gly Ser Leu Leu 
        515                 520                 525             


His Thr Arg Leu Ser Lys Val Lys Asn Ile Ser Pro Asp Phe Leu Thr 
    530                 535                 540                 


Lys Glu Ile Glu His Gln Leu Trp His Ile Ile Tyr Ser Val Thr Asp 
545                 550                 555                 560 


Lys Ile Glu Tyr Glu Gln Ala Leu Lys Thr Phe Ala Arg Lys Asn Asn 
                565                 570                 575     


Leu Asp Val Asp Ser Phe Phe Glu His Phe Lys Lys Ile Pro Pro Phe 
            580                 585                 590         


Glu Ser Thr Tyr Gly Ala Tyr Ser Glu Lys Ala Ile Lys Lys Leu Leu 
        595                 600                 605             


Pro Leu Ile Arg Leu Gly Lys Tyr Trp Asn Trp Glu Ala Ile Asp Ser 
    610                 615                 620                 


Ile Ser Lys Asp Arg Ile Ser Lys Ile Leu Ser Gly Glu Tyr Asp Glu 
625                 630                 635                 640 


Asn Ile Lys Asn Arg Val Arg Glu Lys Ala Val His Leu Thr Ser Glu 
                645                 650                 655     


Asn Asn Phe Gln Gly Leu Gln Glu Trp Leu Ala Lys Tyr Ile Val Tyr 
            660                 665                 670         


Asp Arg His Ser Glu Gly Asn Asp Leu Gly Lys Trp Thr Ser Val Ser 
        675                 680                 685             


Asp Leu Glu Thr Tyr Leu Lys Glu Phe Lys Gln His Ser Leu Arg Asn 
    690                 695                 700                 


Pro Ile Val Glu Gln Val Ile Thr Glu Thr Leu Arg Val Val Lys Asp 
705                 710                 715                 720 


Ile Trp Ile Lys His Gly Lys Gly Thr Glu Asn Phe Phe Asp Glu Ile 
                725                 730                 735     


His Val Glu Leu Gly Arg Glu Met Lys Asn Asn Ser Glu Asp Arg Lys 
            740                 745                 750         


Arg Leu Thr Asn Thr Ile Thr Glu Asn Glu Asn Thr Asn Leu Arg Ile 
        755                 760                 765             


Lys Ala Leu Leu Met Glu Met Met Asn Asp Asn Asp Val Glu Asn Val 
    770                 775                 780                 


Arg Pro Tyr Ser Pro Ser Gln Gln Glu Ile Leu Lys Ile Tyr Glu Asp 
785                 790                 795                 800 


Gly Ala Leu Asn Ser Asn Ile Glu Leu Asp Asp Glu Ile Val Lys Ile 
                805                 810                 815     


Ser Lys Lys Ala Glu Pro Thr Lys Ser Glu Leu Gln Arg Tyr Lys Leu 
            820                 825                 830         


Trp Leu Glu Gln Lys Tyr Arg Ser Pro Tyr Thr Gly Gln Val Ile Pro 
        835                 840                 845             


Leu Asn Lys Leu Phe Thr Ser Glu Tyr Glu Ile Glu His Val Val Pro 
    850                 855                 860                 


Gln Ser Arg Phe Phe Asp Asp Ser Phe Ser Asn Lys Val Ile Cys Glu 
865                 870                 875                 880 


Ser Ala Val Asn Lys Arg Lys Asp Asn Gln Leu Gly Leu Gln Phe Ile 
                885                 890                 895     


Lys Asn His Ser Gly Glu Lys Val Glu Leu Gly Phe Gly Lys Val Val 
            900                 905                 910         


Gln Val Phe Thr Glu Glu Gln Tyr Leu Asp Phe Val Lys Glu His Tyr 
        915                 920                 925             


Ser Lys Asn Arg Ser Lys His Asn Lys Leu Leu Leu Glu Glu Ile Pro 
    930                 935                 940                 


Glu Lys Met Ile Glu Arg Gln Leu Asn Asp Thr Arg Tyr Ile Ser Lys 
945                 950                 955                 960 


Phe Val Ser Ser Ile Leu Ser Asn Ile Val Arg Ser Glu Lys Asp Asp 
                965                 970                 975     


Asp Gly Leu Asn Ser Lys Asn Ile Leu Pro Gly Asn Gly Lys Ile Thr 
            980                 985                 990         


Thr Glu Leu Lys Arg Asp Trp Gly  Leu Asn Asp Val Trp  Asn Asp Leu 
        995                 1000                 1005             


Ile Leu  Pro Arg Phe Glu Arg  Met Asn Thr Ile Thr  Asn Ser Asp 
    1010                 1015                 1020             


Leu Phe  Thr Thr Tyr Asn Asp  Lys Tyr Gln Lys His  Leu Pro Thr 
    1025                 1030                 1035             


Val Pro  Phe Glu Tyr Ser Lys  Gly Phe Gln Lys Lys  Arg Ile Asp 
    1040                 1045                 1050             


His Arg  His His Ala Met Asp  Ala Leu Val Ile Ala  Cys Ala Thr 
    1055                 1060                 1065             


Arg Asp  His Leu Asn Leu Met  Asn Asn Gln Ser Ala  Lys Ser Glu 
    1070                 1075                 1080             


Leu Lys  Arg Tyr Asp Leu Gln  Asn Lys Leu Arg Lys  Lys Glu Pro 
    1085                 1090                 1095             


Tyr Phe  Asn Gln Lys Glu Asn  Lys Gln Lys Glu Ala  Phe Lys Asp 
    1100                 1105                 1110             


Phe Ile  Lys Pro Trp Gly Thr  Phe Thr Glu Asp Ser  Lys Asn Ala 
    1115                 1120                 1125             


Leu Glu  Lys Ile Ile Ile Ser  Phe Lys Gln Asn Leu  Arg Val Ile 
    1130                 1135                 1140             


Asn Lys  Ala Thr Asn Ser Tyr  Glu Ser Tyr Lys Asp  Glu Asp Gly 
    1145                 1150                 1155             


Asn Leu  Arg Ile Gly Lys Asp  Gly Lys Pro Glu Lys  Gly Leu Ile 
    1160                 1165                 1170             


Lys Gln  Lys Gly Leu Asn Trp  Ala Ile Arg Lys Pro  Leu His Lys 
    1175                 1180                 1185             


Asp Thr  Val Ser Gly Gln Ile  Asn Leu Ser Arg Ile  Lys Leu Pro 
    1190                 1195                 1200             


Asn Gly  Lys Ile Leu Thr Ala  Thr Arg Lys Asn Leu  Asp Thr Ser 
    1205                 1210                 1215             


Phe Asp  Leu Lys Thr Ile Glu  Asn Ser Ile Thr Asp  Thr Gly Ile 
    1220                 1225                 1230             


Gln Lys  Ile Leu Lys Asn Tyr  Leu Leu Ser Lys Glu  Ser Pro Glu 
    1235                 1240                 1245             


Leu Ala  Phe Ser Pro Glu Gly  Leu Glu Glu Met Asn  Asn Glu Ile 
    1250                 1255                 1260             


Glu Lys  Tyr Asn Asn Gly Lys  Phe His His Pro Ile  Asn Lys Ala 
    1265                 1270                 1275             


Arg Ile  Tyr Glu Leu Gly Ser  Lys Phe Asn Val Gly  Gln Thr Gly 
    1280                 1285                 1290             


Asn Arg  Arg Asp Lys Phe Val  Glu Ala Ala Lys Gly  Thr Asn Leu 
    1295                 1300                 1305             


Phe Phe  Ala Ile Tyr Gln Asp  Glu Asn Lys Asn Arg  Ser Tyr Glu 
    1310                 1315                 1320             


Thr Ile  Pro Leu Asn Glu Val  Ile Glu His Gln Lys  Trp Arg Ala 
    1325                 1330                 1335             


Ser Leu  Pro Lys Glu Glu Gln  Glu Lys Ile Pro Leu  Val Pro Val 
    1340                 1345                 1350             


Asn Lys  Leu Lys Gly Thr Phe  Ile Phe Ser Leu Ser  Pro Asn Asp 
    1355                 1360                 1365             


Leu Val  Tyr Val Pro Ser Asn  Asp Glu Leu Glu Arg  Ser Ala Ser 
    1370                 1375                 1380             


Ile Asp  Phe Ser Lys Leu Lys  Lys Glu Gln Ile Asn  Arg Leu Tyr 
    1385                 1390                 1395             


Lys Met  Val Ser Ser Ser Gly  Ser Gln Cys Phe Phe  Val Lys Ser 
    1400                 1405                 1410             


Glu Val  Ala Thr Ser Val Val  Asn Lys Met Glu Tyr  Ser Ser Leu 
    1415                 1420                 1425             


Asn Lys  Met Glu Lys Ser Ile  Asp Asn Leu Met Val  Lys Glu Ile 
    1430                 1435                 1440             


Cys Ile  Lys Leu Lys Ile Asp  Arg Leu Gly Asn Ile  Ser Lys Ala 
    1445                 1450                 1455             


<210> 226
<211> 1646
<212> PRT
<213> Francisella tularensis

<400> 226
Met Asn Ile Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Ala Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Ser 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Lys Gln Leu Asn Leu Glu Trp Asn Lys Asp Thr Gln Gln Thr Ile Ser 
                85                  90                  95      


Phe Leu Leu Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Ala Pro Glu Ala Val Lys Ala Ile Leu Met 
        115                 120                 125             


Ser Ile Leu Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Gln Ser Ala Thr Glu Asn Asp Ser Lys Ile Asp Glu Leu Tyr Asn Lys 
145                 150                 155                 160 


Leu Leu Gln Lys Ala Leu Glu Phe Lys Leu Arg Lys Leu Cys Ile Asp 
                165                 170                 175     


Ile Lys Glu Asp Lys Val Thr Thr Lys Thr Leu Lys Glu Leu Ser Asn 
            180                 185                 190         


Thr Glu Phe Lys Leu Leu Ala Asn Tyr Leu Val Asp Tyr Asp Arg Ile 
        195                 200                 205             


Leu Arg Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Arg 
    210                 215                 220                 


Glu Leu Asn Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg Asn Ile Ile Ile Asn Asp Val Ile Leu Glu Lys Leu Thr Asp 
                245                 250                 255     


Asp Leu Asp Ile Trp Asn Leu Asn Phe Asp Lys Phe Asp Phe Glu Lys 
            260                 265                 270         


Asn Leu Glu Lys Leu Glu Asn Gln Glu Asp Lys Asp Tyr Leu Gln Thr 
        275                 280                 285             


His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met 
    290                 295                 300                 


Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr Asn 
305                 310                 315                 320 


Val Leu Val Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe Cys 
                325                 330                 335     


Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu 
            340                 345                 350         


Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg 
        355                 360                 365             


Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp Tyr Trp Asp Glu 
    370                 375                 380                 


Gln Lys Phe Ala Glu Thr Tyr Ser Asp Trp Ile Leu Gly Glu Trp Arg 
385                 390                 395                 400 


Val Gly Ala Lys Asp Lys Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr 
                405                 410                 415     


Lys Asn Leu Cys Asp Glu Leu Lys Gln Lys Val Gly Ile Asn Gln Asp 
            420                 425                 430         


Gly Ile Ile Asn Gln Thr Lys Ser Asp Phe Val Asp Phe Leu Leu Glu 
        435                 440                 445             


Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg 
    450                 455                 460                 


Lys Pro Pro Lys Cys Gln Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp 
465                 470                 475                 480 


Asn Lys Tyr Pro Asn Trp Gln Gln Tyr Leu Gln Glu Leu Lys Lys Leu 
                485                 490                 495     


Gln Thr Val Gln Asn Tyr Leu Gly Asn Phe Glu Ile Asp Leu Lys Asp 
            500                 505                 510         


Leu Lys Ser Ser Lys Glu Gln Pro Tyr Phe Val Lys Tyr Lys Ser Leu 
        515                 520                 525             


Asn Gln Gln Ile Ala Ser Gly Gln Arg Asp Tyr Lys Asp Leu Asp Ala 
    530                 535                 540                 


Arg Val Leu Gln Phe Ile Phe Asp Arg Val Lys Ala Ser Asp Glu Leu 
545                 550                 555                 560 


Leu Leu Asn Glu Ile Tyr Ser His Ala Lys Lys Leu Lys Gln Asn Thr 
                565                 570                 575     


Ser Ser Glu Leu Glu Lys Leu Glu Leu Cys Lys Lys Leu Asp Glu Val 
            580                 585                 590         


Ile Ala Asn Ser Gln Leu Ser Gln Ile Leu Lys Ser Gln His Val Asn 
        595                 600                 605             


Gly Ile Phe Glu Gln Gly Thr Phe Leu His Leu Val Cys Lys Tyr Tyr 
    610                 615                 620                 


Lys Gln Arg Gln Arg Ala Arg Asp Ser Arg Leu Tyr Ile Met Pro Glu 
625                 630                 635                 640 


Tyr Arg Tyr Asp Lys Lys Leu Asp Lys Tyr Asn Asn Thr Gly Arg Phe 
                645                 650                 655     


Asp Asp Asp Asn Gln Leu Leu Thr Tyr Cys Asn His Lys Pro Arg Gln 
            660                 665                 670         


Lys Arg Tyr Gln Leu Leu Asn Asp Leu Ala Gly Val Leu Gln Val Ser 
        675                 680                 685             


Pro Asn Phe Leu Lys Asp Lys Ile Gly Ser Asp Asp Asp Leu Phe Ile 
    690                 695                 700                 


Ser Lys Trp Leu Val Glu His Ile Arg Gly Phe Lys Lys Ala Cys Glu 
705                 710                 715                 720 


Asp Ser Leu Lys Ile Gln Lys Asp Asn Arg Gly Leu Leu Asn His Lys 
                725                 730                 735     


Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile Phe 
            740                 745                 750         


Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn Tyr 
        755                 760                 765             


Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu Pro 
    770                 775                 780                 


Asn Gln Ala Ser Lys Leu Glu Phe Asp Arg Lys Ile Lys Lys Phe Asn 
785                 790                 795                 800 


Ser Ile Tyr Ser Phe Ala Gln Ile Gln Gln Ile Ala Phe Ala Glu Arg 
                805                 810                 815     


Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala His 
            820                 825                 830         


Arg Met Gln Gln Ile Lys Val Ala Lys Pro Val Glu Gly Asn Lys Asp 
        835                 840                 845             


Asn Ile Ile Leu Ser Ala Lys Ala Gln Arg Leu Pro Ala Ile Pro Thr 
    850                 855                 860                 


Arg Ile Val Asp Gly Ala Val Lys Lys Ile Ala Thr Ile Leu Ala Arg 
865                 870                 875                 880 


Asn Ile Val Asp Asp Asn Trp Asp Asn Ile Lys Gln Ala Leu Ser Asn 
                885                 890                 895     


Asn Gln Gln Leu His Val Pro Ile Ile Thr Glu Ser Asn Ala Phe Glu 
            900                 905                 910         


Phe Glu Pro Ala Leu Ala Asp Ile Lys Gly Lys Ser Leu Lys Asp Lys 
        915                 920                 925             


Arg Lys Lys Ala Leu Glu Arg Ile Asp Pro Glu Asn Val Phe Lys Asp 
    930                 935                 940                 


Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr Ser 
945                 950                 955                 960 


Asp Ala Asn Leu Ala Asn Gly Asp Phe Asp Gly Ala Lys Glu Glu Leu 
                965                 970                 975     


Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn Asp 
            980                 985                 990         


Glu Ala Asn Leu Ile Cys Val Thr  Arg Glu Asp Asn Gln  Asn Arg Gly 
        995                 1000                 1005             


Asn Lys  Ala Val Phe Leu Tyr  Asp Leu Lys Pro Asn  Tyr Lys Leu 
    1010                 1015                 1020             


Lys Gln  Phe Asn Thr Thr Asp  Asp Leu Glu Ile Glu  Lys Lys Ile 
    1025                 1030                 1035             


Ala Asp  Thr Ile Trp Asp Ala  Ser Lys Gln Asp Phe  Lys Phe Gly 
    1040                 1045                 1050             


Asn Tyr  Arg Ser Phe Ile Asn  Leu Thr Pro Gln Glu  Gln Ile Ala 
    1055                 1060                 1065             


Phe Arg  His Ala Leu Phe Leu  Ala Asp Lys Asn Pro  Ile Lys Lys 
    1070                 1075                 1080             


Ala Val  Ile Arg Ala Ile Asp  Asn Arg Asn Arg Thr  Phe Val Asn 
    1085                 1090                 1095             


Gly Thr  Gln Arg Tyr Phe Ala  Glu Val Leu Ala Asn  Asn Ile Tyr 
    1100                 1105                 1110             


Leu Arg  Ala Lys Lys Glu Asn  Leu Ala Thr Asn Arg  Ile Thr Phe 
    1115                 1120                 1125             


Asp Tyr  Phe Gly Ile Glu Thr  Thr Asn Ser Asn Gly  Arg Gly Ile 
    1130                 1135                 1140             


Ala Asp  Val Arg Lys Leu Tyr  Glu Lys Val Asp Ser  Asp Ile Gln 
    1145                 1150                 1155             


Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Asp Ser Tyr  Ser His Leu 
    1160                 1165                 1170             


Ile Asp  Ala Met Ile Ala Phe  Cys Val Ala Ala Asp  Glu His Lys 
    1175                 1180                 1185             


Asn Glu  Gly Ser Ile Gly Leu  Lys Met Gly Asn Gln  Tyr Gly Leu 
    1190                 1195                 1200             


Phe Pro  Thr Pro Asp Lys Tyr  Asp Glu Asn Thr Gly  Glu Ile Ile 
    1205                 1210                 1215             


Ser Trp  His Asn Asp Asp Ile  Phe Arg Lys Ile Lys  Val Ser Asp 
    1220                 1225                 1230             


Asn Gln  Phe Ser Asp Lys Lys  Leu Val Arg Lys Lys  Ala Thr Glu 
    1235                 1240                 1245             


Gly Phe  Asn Thr His Arg Gln  Met Thr Arg Asp Gly  Ile Tyr Gly 
    1250                 1255                 1260             


Glu Ser  Tyr Leu Pro Ile Leu  Ile His Lys Asn Leu  Asn Glu Val 
    1265                 1270                 1275             


Arg Lys  Gly Tyr Asn Trp Glu  Asn Ser Glu Glu Ile  Lys Ile Phe 
    1280                 1285                 1290             


Lys Gly  Lys Lys Tyr Asp Ile  Gln Gln Leu Asn Asn  Leu Val Tyr 
    1295                 1300                 1305             


Cys Leu  Lys Phe Val Asp Lys  Pro Ile Ser Ile Asp  Ile Gln Ile 
    1310                 1315                 1320             


Thr Thr  Leu Glu Glu Leu Arg  Asn Ile Leu Glu Thr  Asn Asn Ile 
    1325                 1330                 1335             


Ser Thr  Thr Ala Glu Tyr Tyr  Tyr Ile Asn Leu Lys  Thr Gln Lys 
    1340                 1345                 1350             


Leu His  Glu Tyr Tyr Ile Glu  Asn Tyr Asn Thr Ala  Leu Gly Tyr 
    1355                 1360                 1365             


Lys Lys  Tyr Thr Lys Glu Met  Glu Phe Leu Arg Ser  Leu Ala Tyr 
    1370                 1375                 1380             


Arg Thr  Glu Arg Val Lys Ile  Lys Ser Ile Asp Asp  Val Ser Met 
    1385                 1390                 1395             


Ile Leu  Ala Lys Asp Ser Asn  Phe Lys Ala Gly Lys  Ile Glu Leu 
    1400                 1405                 1410             


Pro Phe  Lys Thr Glu Trp Gln  Arg Leu Tyr Leu Glu  Trp Gln Asn 
    1415                 1420                 1425             


Thr Thr  Ile Lys Asp Asn His  Glu Phe Leu Lys Ser  Tyr Phe Ser 
    1430                 1435                 1440             


Val Lys  Asn Ala Thr Lys Gln  His Lys Lys Val Arg  Lys Asp Phe 
    1445                 1450                 1455             


Ser Leu  Pro Ile Ser Thr Asn  Glu Gly Lys Leu Leu  Val Lys Arg 
    1460                 1465                 1470             


Lys Thr  Trp Asp Asn Asn Phe  Ile Tyr Gln Ile Leu  Asn Asp Ser 
    1475                 1480                 1485             


Asp Ser  Arg Ala Asp Gly Thr  Lys Pro Phe Ile Pro  Ala Phe Asp 
    1490                 1495                 1500             


Ile Ser  Lys Asn Glu Ile Val  Glu Thr Ile Ile Lys  Ser Phe Thr 
    1505                 1510                 1515             


Ser Lys  Asn Ile Phe Trp Leu  Pro Lys Asn Ile Glu  Leu Gln Lys 
    1520                 1525                 1530             


Val Asp  Asn Lys Ser Ile Phe  Ala Ile Asp Thr Ser  Arg Trp Phe 
    1535                 1540                 1545             


Glu Val  Glu Thr Pro Lys Asp  Leu Ile Glu Ile Gly  Val Ser Thr 
    1550                 1555                 1560             


Ile Gln  Tyr Lys Ile Asp Asn  Asn Ser Arg Pro Lys  Val Arg Val 
    1565                 1570                 1575             


Lys Leu  Asp Tyr Val Met Asp  Asp Asp Ser Lys Ile  Asn Tyr Phe 
    1580                 1585                 1590             


Met Asn  His Ser Leu Leu Lys  Ser Arg Tyr Pro Asp  Lys Val Leu 
    1595                 1600                 1605             


Glu Ile  Leu Lys Gln Ser Thr  Ile Ile Glu Phe Glu  Ser Ser Gly 
    1610                 1615                 1620             


Phe Asn  Lys Thr Ile Lys Glu  Met Leu Gly Met Thr  Leu Ala Gly 
    1625                 1630                 1635             


Ile Tyr  Asn Glu Thr Ser Asn  Asn 
    1640                 1645     


<210> 227
<211> 1629
<212> PRT
<213> Francisella tularensis

<400> 227
Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Arg Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ile 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Ile Gln Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Glu Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Arg Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Thr Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asn  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Thr  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asp Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Leu  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Thr  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Ile Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Val  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Val Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Thr Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Thr Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210> 228
<211> 1629
<212> PRT
<213> Francisella novicida


<220>
<223> Francisella novicida FTG

<400> 228
Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Val  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Val Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Thr Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Thr Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Thr Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210> 229
<211> 1629
<212> PRT
<213> Francisella novicida


<220>
<223> Francisella novicida GA99-3548

<400> 229
Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Lys Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Arg Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Glu Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Thr Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Gly Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Leu Lys Asp Gln Asp Lys Lys Glu Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Asn Ala Gly 
            420                 425                 430         


Leu Ile Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ile Ile Gln Asp Tyr Leu Glu Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Lys Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu Asp Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Asp Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  His Asp Leu 
        995                 1000                 1005             


Ala Asn  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Ser Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Val Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Thr  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asp Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Leu  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Thr  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Val  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Val Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Thr Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Thr Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210> 230
<211> 1629
<212> PRT
<213> Francisella tularensis

<400> 230
Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210> 231
<211> 1629
<212> PRT
<213> Francisella novicida


<220>
<223> Francisella novicida GA99-3549

<400> 231
Met Asn Val Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Arg Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ile 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Glu Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Thr Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Gly Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Glu Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu Asp Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Ile Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Asp Asn Leu Ala Ser Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Asp Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  His Asp Leu 
        995                 1000                 1005             


Ala Asn  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Ser Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Val Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asn Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Thr  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asp Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Gly Asn Ser  Glu Glu Leu Lys Ile  His Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Ile Asp Lys Ser Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Thr 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Thr  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Val  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Val Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Thr Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Thr Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210> 232
<211> 1323
<212> PRT
<213> Fructobacillus fructosus


<220>
<223> Fructobacillus fructosus KCTC 3544

<400> 232
Met Val Tyr Asp Val Gly Leu Asp Ile Gly Thr Gly Ser Val Gly Trp 
1               5                   10                  15      


Val Ala Leu Asp Glu Asn Gly Lys Leu Ala Arg Ala Lys Gly Lys Asn 
            20                  25                  30          


Leu Val Gly Val Arg Leu Phe Asp Thr Ala Gln Thr Ala Ala Asp Arg 
        35                  40                  45              


Arg Gly Phe Arg Thr Thr Arg Arg Arg Leu Ser Arg Arg Lys Trp Arg 
    50                  55                  60                  


Leu Arg Leu Leu Asp Glu Leu Phe Ser Ala Glu Ile Asn Glu Ile Asp 
65                  70                  75                  80  


Ser Ser Phe Phe Gln Arg Leu Lys Tyr Ser Tyr Val His Pro Lys Asp 
                85                  90                  95      


Glu Glu Asn Lys Ala His Tyr Tyr Gly Gly Tyr Leu Phe Pro Thr Glu 
            100                 105                 110         


Glu Glu Thr Lys Lys Phe His Arg Ser Tyr Pro Thr Ile Tyr His Leu 
        115                 120                 125             


Arg Gln Glu Leu Met Ala Gln Pro Asn Lys Arg Phe Asp Ile Arg Glu 
    130                 135                 140                 


Ile Tyr Leu Ala Ile His His Leu Val Lys Tyr Arg Gly His Phe Leu 
145                 150                 155                 160 


Ser Ser Gln Glu Lys Ile Thr Ile Gly Ser Thr Tyr Asn Pro Glu Asp 
                165                 170                 175     


Leu Ala Asn Ala Ile Glu Val Tyr Ala Asp Glu Lys Gly Leu Ser Trp 
            180                 185                 190         


Glu Leu Asn Asn Pro Glu Gln Leu Thr Glu Ile Ile Ser Gly Glu Ala 
        195                 200                 205             


Gly Tyr Gly Leu Asn Lys Ser Met Lys Ala Asp Glu Ala Leu Lys Leu 
    210                 215                 220                 


Phe Glu Phe Asp Asn Asn Gln Asp Lys Val Ala Ile Lys Thr Leu Leu 
225                 230                 235                 240 


Ala Gly Leu Thr Gly Asn Gln Ile Asp Phe Ala Lys Leu Phe Gly Lys 
                245                 250                 255     


Asp Ile Ser Asp Lys Asp Glu Ala Lys Leu Trp Lys Leu Lys Leu Asp 
            260                 265                 270         


Asp Glu Ala Leu Glu Glu Lys Ser Gln Thr Ile Leu Ser Gln Leu Thr 
        275                 280                 285             


Asp Glu Glu Ile Glu Leu Phe His Ala Val Val Gln Ala Tyr Asp Gly 
    290                 295                 300                 


Phe Val Leu Ile Gly Leu Leu Asn Gly Ala Asp Ser Val Ser Ala Ala 
305                 310                 315                 320 


Met Val Gln Leu Tyr Asp Gln His Arg Glu Asp Arg Lys Leu Leu Lys 
                325                 330                 335     


Ser Leu Ala Gln Lys Ala Gly Leu Lys His Lys Arg Phe Ser Glu Ile 
            340                 345                 350         


Tyr Glu Gln Leu Ala Leu Ala Thr Asp Glu Ala Thr Ile Lys Asn Gly 
        355                 360                 365             


Ile Ser Thr Ala Arg Glu Leu Val Glu Glu Ser Asn Leu Ser Lys Glu 
    370                 375                 380                 


Val Lys Glu Asp Thr Leu Arg Arg Leu Asp Glu Asn Glu Phe Leu Pro 
385                 390                 395                 400 


Lys Gln Arg Thr Lys Ala Asn Ser Val Ile Pro His Gln Leu His Leu 
                405                 410                 415     


Ala Glu Leu Gln Lys Ile Leu Gln Asn Gln Gly Gln Tyr Tyr Pro Phe 
            420                 425                 430         


Leu Leu Asp Thr Phe Glu Lys Glu Asp Gly Gln Asp Asn Lys Ile Glu 
        435                 440                 445             


Glu Leu Leu Arg Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Val Thr 
    450                 455                 460                 


Lys Lys Asp Val Glu His Ala Gly Gly Asp Ala Asp Asn His Trp Val 
465                 470                 475                 480 


Glu Arg Asn Glu Gly Phe Glu Lys Ser Arg Val Thr Pro Trp Asn Phe 
                485                 490                 495     


Asp Lys Val Phe Asn Arg Asp Lys Ala Ala Arg Asp Phe Ile Glu Arg 
            500                 505                 510         


Leu Thr Gly Asn Asp Thr Tyr Leu Ile Gly Glu Lys Thr Leu Pro Gln 
        515                 520                 525             


Asn Ser Leu Arg Tyr Gln Leu Phe Thr Val Leu Asn Glu Leu Asn Asn 
    530                 535                 540                 


Val Arg Val Asn Gly Lys Lys Phe Asp Ser Lys Thr Lys Ala Asp Leu 
545                 550                 555                 560 


Ile Asn Asp Leu Phe Lys Ala Arg Lys Thr Val Ser Leu Ser Ala Leu 
                565                 570                 575     


Lys Asp Tyr Leu Lys Ala Gln Gly Lys Gly Asp Val Thr Ile Thr Gly 
            580                 585                 590         


Leu Ala Asp Glu Ser Lys Phe Asn Ser Ser Leu Ser Ser Tyr Asn Asp 
        595                 600                 605             


Leu Lys Lys Thr Phe Asp Ala Glu Tyr Leu Glu Asn Glu Asp Asn Gln 
    610                 615                 620                 


Glu Thr Leu Glu Lys Ile Ile Glu Ile Gln Thr Val Phe Glu Asp Ser 
625                 630                 635                 640 


Lys Ile Ala Ser Arg Glu Leu Ser Lys Leu Pro Leu Asp Asp Asp Gln 
                645                 650                 655     


Val Lys Lys Leu Ser Gln Thr His Tyr Thr Gly Trp Gly Arg Leu Ser 
            660                 665                 670         


Glu Lys Leu Leu Asp Ser Lys Ile Ile Asp Glu Arg Gly Gln Lys Val 
        675                 680                 685             


Ser Ile Leu Asp Lys Leu Lys Ser Thr Ser Gln Asn Phe Met Ser Ile 
    690                 695                 700                 


Ile Asn Asn Asp Lys Tyr Gly Val Gln Ala Trp Ile Thr Glu Gln Asn 
705                 710                 715                 720 


Thr Gly Ser Ser Lys Leu Thr Phe Asp Glu Lys Val Asn Glu Leu Thr 
                725                 730                 735     


Thr Ser Pro Ala Asn Lys Arg Gly Ile Lys Gln Ser Phe Ala Val Leu 
            740                 745                 750         


Asn Asp Ile Lys Lys Ala Met Lys Glu Glu Pro Arg Arg Val Tyr Leu 
        755                 760                 765             


Glu Phe Ala Arg Glu Asp Gln Thr Ser Val Arg Ser Val Pro Arg Tyr 
    770                 775                 780                 


Asn Gln Leu Lys Glu Lys Tyr Gln Ser Lys Ser Leu Ser Glu Glu Ala 
785                 790                 795                 800 


Lys Val Leu Lys Lys Thr Leu Asp Gly Asn Lys Asn Lys Met Ser Asp 
                805                 810                 815     


Asp Arg Tyr Phe Leu Tyr Phe Gln Gln Gln Gly Lys Asp Met Tyr Thr 
            820                 825                 830         


Gly Arg Pro Ile Asn Phe Glu Arg Leu Ser Gln Asp Tyr Asp Ile Asp 
        835                 840                 845             


His Ile Ile Pro Gln Ala Phe Thr Lys Asp Asp Ser Leu Asp Asn Arg 
    850                 855                 860                 


Val Leu Val Ser Arg Pro Glu Asn Ala Arg Lys Ser Asp Ser Phe Ala 
865                 870                 875                 880 


Tyr Thr Asp Glu Val Gln Lys Gln Asp Gly Ser Leu Trp Thr Ser Leu 
                885                 890                 895     


Leu Lys Ser Gly Phe Ile Asn Arg Lys Lys Tyr Glu Arg Leu Thr Lys 
            900                 905                 910         


Ala Gly Lys Tyr Leu Asp Gly Gln Lys Thr Gly Phe Ile Ala Arg Gln 
        915                 920                 925             


Leu Val Glu Thr Arg Gln Ile Ile Lys Asn Val Ala Ser Leu Ile Glu 
    930                 935                 940                 


Gly Glu Tyr Glu Asn Ser Lys Ala Val Ala Ile Arg Ser Glu Ile Thr 
945                 950                 955                 960 


Ala Asp Met Arg Leu Leu Val Gly Ile Lys Lys His Arg Glu Ile Asn 
                965                 970                 975     


Ser Phe His His Ala Phe Asp Ala Leu Leu Ile Thr Ala Ala Gly Gln 
            980                 985                 990         


Tyr Met Gln Asn Arg Tyr Pro Asp  Arg Asp Ser Thr Asn  Val Tyr Asn 
        995                 1000                 1005             


Glu Phe  Asp Arg Tyr Thr Asn  Asp Tyr Leu Lys Asn  Leu Arg Gln 
    1010                 1015                 1020             


Leu Ser  Ser Arg Asp Glu Val  Arg Arg Leu Lys Ser  Phe Gly Phe 
    1025                 1030                 1035             


Val Val  Gly Thr Met Arg Lys  Gly Asn Glu Asp Trp  Ser Glu Glu 
    1040                 1045                 1050             


Asn Thr  Ser Tyr Leu Arg Lys  Val Met Met Phe Lys  Asn Ile Leu 
    1055                 1060                 1065             


Thr Thr  Lys Lys Thr Glu Lys  Asp Arg Gly Pro Leu  Asn Lys Glu 
    1070                 1075                 1080             


Thr Ile  Phe Ser Pro Lys Ser  Gly Lys Lys Leu Ile  Pro Leu Asn 
    1085                 1090                 1095             


Ser Lys  Arg Ser Asp Thr Ala  Leu Tyr Gly Gly Tyr  Ser Asn Val 
    1100                 1105                 1110             


Tyr Ser  Ala Tyr Met Thr Leu  Val Arg Ala Asn Gly  Lys Asn Leu 
    1115                 1120                 1125             


Leu Ile  Lys Ile Pro Ile Ser  Ile Ala Asn Gln Ile  Glu Val Gly 
    1130                 1135                 1140             


Asn Leu  Lys Ile Asn Asp Tyr  Ile Val Asn Asn Pro  Ala Ile Lys 
    1145                 1150                 1155             


Lys Phe  Glu Lys Ile Leu Ile  Ser Lys Leu Pro Leu  Gly Gln Leu 
    1160                 1165                 1170             


Val Asn  Glu Asp Gly Asn Leu  Ile Tyr Leu Ala Ser  Asn Glu Tyr 
    1175                 1180                 1185             


Arg His  Asn Ala Lys Gln Leu  Trp Leu Ser Thr Thr  Asp Ala Asp 
    1190                 1195                 1200             


Lys Ile  Ala Ser Ile Ser Glu  Asn Ser Ser Asp Glu  Glu Leu Leu 
    1205                 1210                 1215             


Glu Ala  Tyr Asp Ile Leu Thr  Ser Glu Asn Val Lys  Asn Arg Phe 
    1220                 1225                 1230             


Pro Phe  Phe Lys Lys Asp Ile  Asp Lys Leu Ser Gln  Val Arg Asp 
    1235                 1240                 1245             


Glu Phe  Leu Asp Ser Asp Lys  Arg Ile Ala Val Ile  Gln Thr Ile 
    1250                 1255                 1260             


Leu Arg  Gly Leu Gln Ile Asp  Ala Ala Tyr Gln Ala  Pro Val Lys 
    1265                 1270                 1275             


Ile Ile  Ser Lys Lys Val Ser  Asp Trp His Lys Leu  Gln Gln Ser 
    1280                 1285                 1290             


Gly Gly  Ile Lys Leu Ser Asp  Asn Ser Glu Met Ile  Tyr Gln Ser 
    1295                 1300                 1305             


Ala Thr  Gly Ile Phe Glu Thr  Arg Val Lys Ile Ser  Asp Leu Leu 
    1310                 1315                 1320             


<210> 233
<211> 1374
<212> PRT
<213> Fusobacterium nucleatum


<220>
<223> Fusobacterium nucleatum subsp. vincentii ATCC 49256

<400> 233
Met Lys Lys Gln Lys Phe Ser Asp Tyr Tyr Leu Gly Phe Asp Ile Gly 
1               5                   10                  15      


Thr Asn Ser Val Gly Trp Cys Val Thr Asp Leu Asp Tyr Asn Val Leu 
            20                  25                  30          


Arg Phe Asn Lys Lys Asp Met Trp Gly Ser Arg Leu Phe Asp Glu Ala 
        35                  40                  45              


Lys Thr Ala Ala Glu Arg Arg Val Gln Arg Asn Ser Arg Arg Arg Leu 
    50                  55                  60                  


Lys Arg Arg Lys Trp Arg Leu Asn Leu Leu Glu Glu Ile Phe Ser Asp 
65                  70                  75                  80  


Glu Ile Met Lys Ile Asp Ser Asn Phe Phe Arg Arg Leu Lys Glu Ser 
                85                  90                  95      


Ser Leu Trp Leu Glu Asp Lys Asn Ser Lys Glu Lys Phe Thr Leu Phe 
            100                 105                 110         


Asn Asp Asp Asn Tyr Lys Asp Tyr Asp Phe Tyr Lys Gln Tyr Pro Thr 
        115                 120                 125             


Ile Phe His Leu Arg Asp Glu Leu Ile Lys Asn Pro Glu Lys Lys Asp 
    130                 135                 140                 


Ile Arg Leu Ile Tyr Leu Ala Leu His Ser Ile Phe Lys Ser Arg Gly 
145                 150                 155                 160 


His Phe Leu Phe Glu Gly Gln Asn Leu Lys Glu Ile Lys Asn Phe Glu 
                165                 170                 175     


Thr Leu Tyr Asn Asn Leu Ile Ser Phe Leu Glu Asp Asn Gly Ile Asn 
            180                 185                 190         


Lys Ser Ile Asp Lys Asp Asn Ile Glu Lys Leu Glu Lys Ile Ile Cys 
        195                 200                 205             


Asp Ser Gly Lys Gly Leu Lys Asp Lys Glu Lys Glu Phe Lys Gly Ile 
    210                 215                 220                 


Phe Asn Ser Asp Lys Gln Leu Val Ala Ile Phe Lys Leu Ser Val Gly 
225                 230                 235                 240 


Ser Ser Val Ser Leu Asn Asp Leu Phe Asp Thr Asp Glu Tyr Lys Lys 
                245                 250                 255     


Glu Glu Val Glu Lys Glu Lys Ile Ser Phe Arg Glu Gln Ile Tyr Glu 
            260                 265                 270         


Asp Asp Lys Pro Ile Tyr Tyr Ser Ile Leu Gly Glu Lys Ile Glu Leu 
        275                 280                 285             


Leu Asp Ile Ala Lys Ser Phe Tyr Asp Phe Met Val Leu Asn Asn Ile 
    290                 295                 300                 


Leu Ser Asp Ser Asn Tyr Ile Ser Glu Ala Lys Val Lys Leu Tyr Glu 
305                 310                 315                 320 


Glu His Lys Lys Asp Leu Lys Asn Leu Lys Tyr Ile Ile Arg Lys Tyr 
                325                 330                 335     


Asn Lys Glu Asn Tyr Asp Lys Leu Phe Lys Asp Lys Asn Glu Asn Asn 
            340                 345                 350         


Tyr Pro Ala Tyr Ile Gly Leu Asn Lys Glu Lys Asp Lys Lys Glu Val 
        355                 360                 365             


Val Glu Lys Ser Arg Leu Lys Ile Asp Asp Leu Ile Lys Val Ile Lys 
    370                 375                 380                 


Gly Tyr Leu Pro Lys Pro Glu Arg Ile Glu Glu Lys Asp Lys Thr Ile 
385                 390                 395                 400 


Phe Asn Glu Ile Leu Asn Lys Ile Glu Leu Lys Thr Ile Leu Pro Lys 
                405                 410                 415     


Gln Arg Ile Ser Asp Asn Gly Thr Leu Pro Tyr Gln Ile His Glu Val 
            420                 425                 430         


Glu Leu Glu Lys Ile Leu Glu Asn Gln Ser Lys Tyr Tyr Asp Phe Leu 
        435                 440                 445             


Asn Tyr Glu Glu Asn Gly Val Ser Thr Lys Asp Lys Leu Leu Lys Thr 
    450                 455                 460                 


Phe Lys Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Asn Ser Tyr His 
465                 470                 475                 480 


Lys Asp Lys Gly Gly Asn Ser Trp Ile Val Arg Lys Glu Glu Gly Lys 
                485                 490                 495     


Ile Leu Pro Trp Asn Phe Glu Gln Lys Val Asp Ile Glu Lys Ser Ala 
            500                 505                 510         


Glu Glu Phe Ile Lys Arg Met Thr Asn Lys Cys Thr Tyr Leu Asn Gly 
        515                 520                 525             


Glu Asp Val Ile Pro Lys Asp Ser Phe Leu Tyr Ser Glu Tyr Ile Ile 
    530                 535                 540                 


Leu Asn Glu Leu Asn Lys Val Gln Val Asn Asp Glu Phe Leu Asn Glu 
545                 550                 555                 560 


Glu Asn Lys Arg Lys Ile Ile Asp Glu Leu Phe Lys Glu Asn Lys Lys 
                565                 570                 575     


Val Ser Glu Lys Lys Phe Lys Glu Tyr Leu Leu Val Asn Gln Ile Ala 
            580                 585                 590         


Asn Arg Thr Val Glu Leu Lys Gly Ile Lys Asp Ser Phe Asn Ser Asn 
        595                 600                 605             


Tyr Val Ser Tyr Ile Lys Phe Lys Asp Ile Phe Gly Glu Lys Leu Asn 
    610                 615                 620                 


Leu Asp Ile Tyr Lys Glu Ile Ser Glu Lys Ser Ile Leu Trp Lys Cys 
625                 630                 635                 640 


Leu Tyr Gly Asp Asp Lys Lys Ile Phe Glu Lys Lys Ile Lys Asn Glu 
                645                 650                 655     


Tyr Gly Asp Ile Leu Asn Lys Asp Glu Ile Lys Lys Ile Asn Ser Phe 
            660                 665                 670         


Lys Phe Asn Thr Trp Gly Arg Leu Ser Glu Lys Leu Leu Thr Gly Ile 
        675                 680                 685             


Glu Phe Ile Asn Leu Glu Thr Gly Glu Cys Tyr Ser Ser Val Met Glu 
    690                 695                 700                 


Ala Leu Arg Arg Thr Asn Tyr Asn Leu Met Glu Leu Leu Ser Ser Lys 
705                 710                 715                 720 


Phe Thr Leu Gln Glu Ser Ile Asp Asn Glu Asn Lys Glu Met Asn Glu 
                725                 730                 735     


Val Ser Tyr Arg Asp Leu Ile Glu Glu Ser Tyr Val Ser Pro Ser Leu 
            740                 745                 750         


Lys Arg Ala Ile Leu Gln Thr Leu Lys Ile Tyr Glu Glu Ile Lys Lys 
        755                 760                 765             


Ile Thr Gly Arg Val Pro Lys Lys Val Phe Ile Glu Met Ala Arg Gly 
    770                 775                 780                 


Gly Asp Glu Ser Met Lys Asn Lys Lys Ile Pro Ala Arg Gln Glu Gln 
785                 790                 795                 800 


Leu Lys Lys Leu Tyr Asp Ser Cys Gly Asn Asp Ile Ala Asn Phe Ser 
                805                 810                 815     


Ile Asp Ile Lys Glu Met Lys Asn Ser Leu Ser Ser Tyr Asp Asn Asn 
            820                 825                 830         


Ser Leu Arg Gln Lys Lys Leu Tyr Leu Tyr Tyr Leu Gln Phe Gly Lys 
        835                 840                 845             


Cys Met Tyr Thr Gly Arg Glu Ile Asp Leu Asp Arg Leu Leu Gln Asn 
    850                 855                 860                 


Asn Asp Thr Tyr Asp Ile Asp His Ile Tyr Pro Arg Ser Lys Val Ile 
865                 870                 875                 880 


Lys Asp Asp Ser Phe Asp Asn Leu Val Leu Val Leu Lys Asn Glu Asn 
                885                 890                 895     


Ala Glu Lys Ser Asn Glu Tyr Pro Val Lys Lys Glu Ile Gln Glu Lys 
            900                 905                 910         


Met Lys Ser Phe Trp Arg Phe Leu Lys Glu Lys Asn Phe Ile Ser Asp 
        915                 920                 925             


Glu Lys Tyr Lys Arg Leu Thr Gly Lys Asp Asp Phe Glu Leu Arg Gly 
    930                 935                 940                 


Phe Met Ala Arg Gln Leu Val Asn Val Arg Gln Thr Thr Lys Glu Val 
945                 950                 955                 960 


Gly Lys Ile Leu Gln Gln Ile Glu Pro Glu Ile Lys Ile Val Tyr Ser 
                965                 970                 975     


Lys Ala Glu Ile Ala Ser Ser Phe Arg Glu Met Phe Asp Phe Ile Lys 
            980                 985                 990         


Val Arg Glu Leu Asn Asp Thr His  His Ala Lys Asp Ala  Tyr Leu Asn 
        995                 1000                 1005             


Ile Val  Ala Gly Asn Val Tyr  Asn Thr Lys Phe Thr  Glu Lys Pro 
    1010                 1015                 1020             


Tyr Arg  Tyr Leu Gln Glu Ile  Lys Glu Asn Tyr Asp  Val Lys Lys 
    1025                 1030                 1035             


Ile Tyr  Asn Tyr Asp Ile Lys  Asn Ala Trp Asp Lys  Glu Asn Ser 
    1040                 1045                 1050             


Leu Glu  Ile Val Lys Lys Asn  Met Glu Lys Asn Thr  Val Asn Ile 
    1055                 1060                 1065             


Thr Arg  Phe Ile Lys Glu Glu  Lys Gly Glu Leu Phe  Asn Leu Asn 
    1070                 1075                 1080             


Pro Ile  Lys Lys Gly Glu Thr  Ser Asn Glu Ile Ile  Ser Ile Lys 
    1085                 1090                 1095             


Pro Lys  Leu Tyr Asp Gly Lys  Asp Asn Lys Leu Asn  Glu Lys Tyr 
    1100                 1105                 1110             


Gly Tyr  Tyr Thr Ser Leu Lys  Ala Ala Tyr Phe Ile  Tyr Val Glu 
    1115                 1120                 1125             


His Glu  Lys Lys Asn Lys Lys  Val Lys Thr Phe Glu  Arg Ile Thr 
    1130                 1135                 1140             


Arg Ile  Asp Ser Thr Leu Ile  Lys Asn Glu Lys Asn  Leu Ile Lys 
    1145                 1150                 1155             


Tyr Leu  Val Ser Gln Lys Lys  Leu Leu Asn Pro Lys  Ile Ile Lys 
    1160                 1165                 1170             


Lys Ile  Tyr Lys Glu Gln Thr  Leu Ile Ile Asp Ser  Tyr Pro Tyr 
    1175                 1180                 1185             


Thr Phe  Thr Gly Val Asp Ser  Asn Lys Lys Val Glu  Leu Lys Asn 
    1190                 1195                 1200             


Lys Lys  Gln Leu Tyr Leu Glu  Lys Lys Tyr Glu Gln  Ile Leu Lys 
    1205                 1210                 1215             


Asn Ala  Leu Lys Phe Val Glu  Asp Asn Gln Gly Glu  Thr Glu Glu 
    1220                 1225                 1230             


Asn Tyr  Lys Phe Ile Tyr Leu  Lys Lys Arg Asn Asn  Asn Glu Lys 
    1235                 1240                 1245             


Asn Glu  Thr Ile Asp Ala Val  Lys Glu Arg Tyr Asn  Ile Glu Phe 
    1250                 1255                 1260             


Asn Glu  Met Tyr Asp Lys Phe  Leu Glu Lys Leu Ser  Ser Lys Asp 
    1265                 1270                 1275             


Tyr Lys  Asn Tyr Ile Asn Asn  Lys Leu Tyr Thr Asn  Phe Leu Asn 
    1280                 1285                 1290             


Ser Lys  Glu Lys Phe Lys Lys  Leu Lys Leu Trp Glu  Lys Ser Leu 
    1295                 1300                 1305             


Ile Leu  Arg Glu Phe Leu Lys  Ile Phe Asn Lys Asn  Thr Tyr Gly 
    1310                 1315                 1320             


Lys Tyr  Glu Ile Lys Asp Ser  Gln Thr Lys Glu Lys  Leu Phe Ser 
    1325                 1330                 1335             


Phe Pro  Glu Asp Thr Gly Arg  Ile Arg Leu Gly Gln  Ser Ser Leu 
    1340                 1345                 1350             


Gly Asn  Asn Lys Glu Leu Leu  Glu Glu Ser Val Thr  Gly Leu Phe 
    1355                 1360                 1365             


Val Lys  Lys Ile Lys Leu 
    1370                 


<210> 234
<211> 1367
<212> PRT
<213> Fusobacterium sp.


<220>
<223> Fusobacterium sp. 1_1_41FAA

<400> 234
Met Lys Lys Gln Gln Phe Ser Asp Tyr Tyr Leu Gly Phe Asp Ile Gly 
1               5                   10                  15      


Thr Asn Ser Val Gly Trp Cys Val Thr Asp Phe Asn Tyr Asn Val Leu 
            20                  25                  30          


Arg Phe Asn Lys Lys Asp Met Trp Gly Ser Arg Leu Phe Asp Glu Ala 
        35                  40                  45              


Lys Thr Ala Ala Glu Arg Arg Val Gln Arg Asn Ser Arg Arg Arg Leu 
    50                  55                  60                  


Lys Arg Arg Lys Trp Arg Leu Asn Leu Leu Glu Glu Ile Phe Ser Asp 
65                  70                  75                  80  


Glu Ile Leu Lys Ile Asp Ser Asn Phe Phe Arg Arg Leu Lys Glu Ser 
                85                  90                  95      


Ser Leu Trp Leu Glu Asp Lys Ser Ser Lys Glu Lys Phe Thr Leu Phe 
            100                 105                 110         


Asn Asp Asp Asn Tyr Lys Asp Tyr Asp Phe Tyr Lys Gln Tyr Pro Thr 
        115                 120                 125             


Ile Phe His Leu Arg Asn Glu Leu Ile Lys Asn Pro Glu Lys Lys Asp 
    130                 135                 140                 


Ile Arg Leu Val Tyr Leu Ala Leu His Ser Ile Phe Lys Ser Arg Gly 
145                 150                 155                 160 


His Phe Leu Phe Glu Gly Gln Asn Leu Lys Asp Ile Lys Asn Phe Glu 
                165                 170                 175     


Thr Leu Tyr Asn Asn Leu Met Ala Phe Leu Glu Asp Asn Asp Ile Tyr 
            180                 185                 190         


Lys Asn Ile Asp Ser Ser Tyr Ile Gly Asn Leu Glu Asn Ile Ile Cys 
        195                 200                 205             


Asp Ser Lys Lys Gly Leu Lys Asp Lys Glu Lys Glu Phe Lys Glu Ile 
    210                 215                 220                 


Phe Asn Ser Asp Lys Gln Leu Val Gly Phe Phe Lys Leu Ser Val Gly 
225                 230                 235                 240 


Ser Ser Val Ser Leu Asn Asp Leu Phe Asp Thr Asp Glu Tyr Lys Lys 
                245                 250                 255     


Gly Glu Val Glu Lys Glu Lys Ile Ser Phe Arg Glu Gln Ile Tyr Glu 
            260                 265                 270         


Asp Asp Lys Pro Ile Tyr Tyr Ser Ile Leu Gly Glu Lys Ile Glu Phe 
        275                 280                 285             


Leu Asp Ile Ala Lys Ser Phe Tyr Asp Phe Met Val Leu Asn Asn Ile 
    290                 295                 300                 


Leu Ala Asp Ser Gln Tyr Ile Ser Glu Ala Lys Val Lys Leu Tyr Asp 
305                 310                 315                 320 


Glu His Lys Arg Asp Leu Lys Asn Leu Lys Tyr Ile Ile Arg Lys Tyr 
                325                 330                 335     


Asn Lys Glu Asn Tyr Asp Lys Leu Phe Lys Asp Lys Asn Glu Ser Asn 
            340                 345                 350         


Tyr Ser Ala Tyr Ile Gly Leu Asn Lys Glu Lys Gly Lys Lys Glu Val 
        355                 360                 365             


Ile Glu Lys Ser Arg Leu Lys Ile Asp Asp Phe Ala Lys Ile Ile Lys 
    370                 375                 380                 


Gly Tyr Leu Pro Lys Ala Glu Lys Ile Asp Glu Lys Asp Arg Ser Ile 
385                 390                 395                 400 


Phe Asn Glu Ile Leu Asp Lys Ile Glu Leu Lys Thr Ile Leu Pro Lys 
                405                 410                 415     


Gln Arg Ile Ser Asp Asn Gly Thr Leu Pro Tyr Gln Ile His Glu Ala 
            420                 425                 430         


Glu Leu Glu Lys Ile Leu Glu Asn Gln Ala Lys Tyr Tyr Asp Phe Leu 
        435                 440                 445             


Asn His Glu Glu Asn Gly Ile Ser Thr Lys Asp Lys Leu Leu Met Thr 
    450                 455                 460                 


Phe Lys Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Asn Ser Tyr His 
465                 470                 475                 480 


Lys Asn Lys Gly Gly Asn Ser Trp Ile Val Arg Lys Glu Glu Gly Lys 
                485                 490                 495     


Ile Leu Pro Trp Asn Phe Glu Gln Lys Val Asp Ile Glu Lys Ser Ala 
            500                 505                 510         


Glu Glu Phe Ile Lys Arg Met Thr Asn Lys Cys Thr Tyr Leu Asn Gly 
        515                 520                 525             


Glu Asp Val Ile Pro Lys Asp Ser Phe Leu Tyr Ser Glu Tyr Ile Ile 
    530                 535                 540                 


Leu Asn Glu Leu Asn Lys Val Gln Val Asn Asp Glu Phe Leu Asn Lys 
545                 550                 555                 560 


Glu Ile Lys Lys Lys Ile Ile Glu Asp Leu Phe Lys Lys Ser Lys Lys 
                565                 570                 575     


Ile Ser Glu Lys Asn Phe Arg Glu Tyr Leu Leu Val Asn Gln Ile Thr 
            580                 585                 590         


Asn Lys Thr Val Glu Leu Lys Gly Val Lys Asp Ala Phe Asn Ser Asn 
        595                 600                 605             


Tyr Val Ser Tyr Ile Lys Phe Lys Asp Ile Phe Gly Asp Lys Leu Asn 
    610                 615                 620                 


Leu Asp Ile Tyr Lys Glu Ile Ser Glu Lys Ser Ile Leu Trp Lys Cys 
625                 630                 635                 640 


Leu Tyr Gly Asp Asp Lys Lys Ile Phe Glu Lys Lys Ile Lys Ser Val 
                645                 650                 655     


Tyr Gly Asp Ile Leu Thr Lys Asp Glu Ile Lys Lys Ile Asn Ser Phe 
            660                 665                 670         


Lys Phe Asn Thr Trp Gly Arg Leu Ser Glu Lys Leu Leu Thr Glu Ile 
        675                 680                 685             


Glu Phe Ile Asp Leu Glu Thr Gly Glu Cys Tyr Ser Ser Val Met Asp 
    690                 695                 700                 


Ala Leu Arg Arg Thr Asn Tyr Asn Leu Met Glu Leu Leu Ser Ser Lys 
705                 710                 715                 720 


Phe Thr Leu Gln Glu Asn Ile Asp Asn Glu Asn Lys Glu Val Ser Glu 
                725                 730                 735     


Phe Ser Tyr Arg Asp Leu Val Glu Glu Ser Tyr Val Ser Pro Ser Leu 
            740                 745                 750         


Lys Arg Ala Ile Leu Gln Thr Leu Lys Ile Tyr Glu Glu Ile Arg Lys 
        755                 760                 765             


Ile Thr Gly Arg Ile Pro Lys Lys Val Phe Ile Glu Met Ala Arg Gly 
    770                 775                 780                 


Gly Asp Glu Thr Met Lys Asn Lys Lys Ile Pro Ala Arg Gln Glu Gln 
785                 790                 795                 800 


Leu Lys Lys Leu Tyr Asp Ser Cys Gly Lys Asp Ile Ser Asn Phe Ser 
                805                 810                 815     


Ile Asp Ile Lys Glu Met Lys Asn Ser Leu Asn Ser Tyr Asp Asn Asn 
            820                 825                 830         


Ser Leu Arg Gln Lys Lys Leu Tyr Leu Tyr Tyr Leu Gln Phe Gly Lys 
        835                 840                 845             


Cys Met Tyr Thr Gly Lys Glu Ile Asp Leu Asn Arg Leu Leu Gln Asn 
    850                 855                 860                 


Asn Asp Thr Tyr Asp Ile Asp His Ile Tyr Pro Arg Ser Lys Val Ile 
865                 870                 875                 880 


Lys Asp Asp Ser Phe Asp Asn Leu Val Leu Val Leu Lys Asn Glu Asn 
                885                 890                 895     


Ala Glu Lys Ser Asn Glu Tyr Pro Leu Lys Lys Glu Ile Gln Glu Lys 
            900                 905                 910         


Met Lys Ser Phe Trp Lys Phe Leu Lys Glu Lys Asn Phe Ile Ser Asp 
        915                 920                 925             


Glu Lys Tyr Lys Arg Leu Thr Gly Lys Asp Glu Phe Glu Leu Arg Gly 
    930                 935                 940                 


Phe Met Ala Arg Gln Leu Val Asn Val Arg Gln Thr Thr Lys Glu Ala 
945                 950                 955                 960 


Gly Lys Ile Leu Gln Gln Ile Glu Pro Glu Ile Lys Ile Val Tyr Ser 
                965                 970                 975     


Lys Ala Glu Ile Ala Ser Ser Phe Arg Glu Met Phe Asp Phe Ile Lys 
            980                 985                 990         


Val Arg Glu Leu Asn Asp Thr His  His Ala Lys Asp Ala  Tyr Leu Asn 
        995                 1000                 1005             


Ile Val  Ala Gly Asn Val Tyr  Asn Thr Lys Phe Thr  Glu Lys Pro 
    1010                 1015                 1020             


Tyr Arg  Tyr Leu Gln Glu Ile  Lys Glu Asn Tyr Asp  Val Lys Lys 
    1025                 1030                 1035             


Ile Tyr  Asn Tyr Asp Ile Lys  Asn Ala Trp Asp Lys  Glu Lys Ser 
    1040                 1045                 1050             


Leu Glu  Ile Val Lys Lys Asn  Met Glu Lys Asn Thr  Val Asn Ile 
    1055                 1060                 1065             


Thr Arg  Phe Ile Lys Glu Glu  Lys Gly Gln Leu Phe  Asp Leu Asn 
    1070                 1075                 1080             


Pro Ile  Arg Lys Gly Glu Thr  Ser Asn Glu Ile Ile  Ala Ile Lys 
    1085                 1090                 1095             


Pro Lys  Phe Tyr Glu Gly Ser  Thr Glu Lys Leu Asn  Glu Lys Tyr 
    1100                 1105                 1110             


Gly Tyr  Tyr Lys Ser Leu Asn  Pro Ala Tyr Phe Ile  Tyr Val Glu 
    1115                 1120                 1125             


His Lys  Glu Lys Asn Lys Ile  Ile Arg Ser Phe Glu  Arg Val Asn 
    1130                 1135                 1140             


Leu Val  Asp Val Asn Lys Ile  Lys Asp Glu Lys Ser  Leu Ile Lys 
    1145                 1150                 1155             


Tyr Leu  Ile Glu Asn Lys Gly  Leu Ile Glu Pro Lys  Val Ile Lys 
    1160                 1165                 1170             


Lys Val  Tyr Lys Arg Gln Val  Ile Leu Ile Asn Asn  Phe Pro Tyr 
    1175                 1180                 1185             


Ser Ile  Val Ala Leu Asp Ser  Asn Lys Leu Met Asp  Phe Glu Asn 
    1190                 1195                 1200             


Leu Lys  Pro Leu Phe Leu Glu  Arg Lys Tyr Glu Lys  Ile Leu Lys 
    1205                 1210                 1215             


Asn Ala  Ile Lys Phe Leu Glu  Asp Asn Gln Gly Lys  Thr Glu Glu 
    1220                 1225                 1230             


Tyr Tyr  Lys Phe Leu Tyr Leu  Lys Lys Lys Asp Arg  Asn Glu Lys 
    1235                 1240                 1245             


Asn Glu  Thr Ile Asp Ser Val  Lys Glu Arg Tyr Asn  Ile Glu Phe 
    1250                 1255                 1260             


Asn Glu  Met Tyr Asp Lys Phe  Leu Glu Lys Leu Asp  Ser Lys Asp 
    1265                 1270                 1275             


Tyr Lys  Asn Tyr Ile Asn Asn  Lys Lys Tyr Ser Glu  Leu Val Asn 
    1280                 1285                 1290             


Val Lys  Glu Lys Phe Ile Lys  Leu Asn Leu Phe Asp  Lys Ala Phe 
    1295                 1300                 1305             


Thr Leu  Lys Ser Phe Leu Asp  Leu Phe Asn Arg Lys  Thr Met Ala 
    1310                 1315                 1320             


Asp Phe  Ser Lys Val Gly Leu  Thr Lys Tyr Leu Gly  Lys Ile Gln 
    1325                 1330                 1335             


Lys Ile  Ser Ser Asn Val Leu  Ser Lys Asn Glu Leu  His Leu Leu 
    1340                 1345                 1350             


Glu Glu  Ser Val Thr Gly Leu  Phe Val Lys Lys Ile  Lys Leu 
    1355                 1360                 1365         


<210> 235
<211> 1367
<212> PRT
<213> Fusobacterium sp.


<220>
<223> Fusobacterium sp. 3_1_27

<400> 235
Met Lys Lys Gln Lys Phe Ser Asp Tyr Tyr Leu Gly Phe Asp Ile Gly 
1               5                   10                  15      


Thr Asn Ser Val Gly Trp Cys Val Thr Asp Leu Asp Tyr Asn Val Leu 
            20                  25                  30          


Arg Phe Asn Lys Lys Asp Met Trp Gly Ser Arg Leu Phe Asp Glu Ala 
        35                  40                  45              


Lys Thr Ala Ala Glu Arg Arg Val Gln Arg Asn Ser Arg Arg Arg Leu 
    50                  55                  60                  


Lys Arg Arg Lys Trp Arg Leu Asn Leu Leu Glu Glu Ile Phe Ser Asp 
65                  70                  75                  80  


Glu Ile Met Lys Ile Asp Ser Asn Phe Phe Arg Arg Leu Lys Glu Ser 
                85                  90                  95      


Ser Leu Trp Leu Glu Asp Lys Asn Ser Lys Glu Lys Phe Thr Leu Phe 
            100                 105                 110         


Asn Asp Asp Asn Tyr Lys Asp Tyr Asp Phe Tyr Lys Gln Tyr Pro Thr 
        115                 120                 125             


Ile Phe His Leu Arg Asp Glu Leu Ile Lys Asn Pro Glu Lys Lys Asp 
    130                 135                 140                 


Ile Arg Leu Ile Tyr Leu Ala Leu His Ser Ile Phe Lys Ser Arg Gly 
145                 150                 155                 160 


His Phe Leu Phe Glu Gly Gln Asn Leu Lys Glu Ile Lys Asn Phe Glu 
                165                 170                 175     


Thr Leu Tyr Asn Asn Leu Ile Ser Phe Leu Glu Asp Asn Gly Ile Asn 
            180                 185                 190         


Lys Ser Ile Asp Lys Asp Asn Ile Lys Lys Leu Glu Lys Ile Ile Cys 
        195                 200                 205             


Asp Ser Gly Lys Gly Leu Lys Asp Lys Glu Lys Glu Phe Lys Glu Ile 
    210                 215                 220                 


Phe Asn Ser Asp Lys Gln Leu Val Ala Ile Phe Lys Leu Ser Val Gly 
225                 230                 235                 240 


Ser Ser Val Ser Leu Asn Asp Leu Phe Asp Thr Asp Glu Tyr Lys Lys 
                245                 250                 255     


Glu Glu Val Glu Lys Glu Lys Ile Ser Phe Arg Glu Gln Ile Tyr Glu 
            260                 265                 270         


Asp Asp Lys Pro Ile Tyr Tyr Ser Ile Leu Gly Glu Lys Ile Glu Leu 
        275                 280                 285             


Leu Asp Ile Ala Lys Ser Phe Tyr Asp Phe Met Val Leu Asn Asn Ile 
    290                 295                 300                 


Leu Ser Asp Ser Asn Tyr Ile Ser Glu Ala Lys Val Lys Leu Tyr Glu 
305                 310                 315                 320 


Glu His Lys Lys Asp Leu Lys Asn Leu Lys Tyr Ile Ile Arg Lys Tyr 
                325                 330                 335     


Asn Lys Glu Asn Tyr Asp Lys Leu Phe Lys Asp Lys Asn Glu Asn Asn 
            340                 345                 350         


Tyr Pro Ala Tyr Ile Gly Leu Asn Lys Glu Lys Gly Lys Lys Glu Val 
        355                 360                 365             


Val Glu Lys Ser Gly Leu Lys Ile Asp Asp Leu Ile Lys Val Ile Lys 
    370                 375                 380                 


Gly Tyr Leu Pro Lys Pro Glu Arg Ile Glu Glu Lys Asp Lys Ile Ile 
385                 390                 395                 400 


Phe Asn Glu Ile Leu Asn Lys Ile Glu Leu Lys Thr Ile Leu Pro Lys 
                405                 410                 415     


Gln Arg Ile Ser Asp Asn Gly Thr Leu Pro Tyr Gln Ile His Glu Val 
            420                 425                 430         


Glu Leu Glu Lys Ile Leu Glu Asn Gln Ser Lys Tyr Tyr Asp Phe Leu 
        435                 440                 445             


Asn Tyr Glu Glu Asn Gly Val Ser Thr Lys Asp Lys Leu Leu Lys Thr 
    450                 455                 460                 


Phe Lys Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Asn Ser Tyr His 
465                 470                 475                 480 


Lys Asp Lys Gly Gly Asn Ser Trp Ile Val Arg Lys Glu Glu Gly Lys 
                485                 490                 495     


Ile Leu Pro Trp Asn Phe Glu Gln Lys Val Asp Ile Glu Lys Ser Ala 
            500                 505                 510         


Glu Glu Phe Ile Lys Arg Met Thr Asn Lys Cys Thr Tyr Leu Asn Gly 
        515                 520                 525             


Glu Asp Val Ile Pro Lys Asp Ser Phe Leu Tyr Ser Glu Tyr Ile Ile 
    530                 535                 540                 


Leu Asn Glu Leu Asn Lys Val Gln Val Asn Asp Glu Phe Leu Asn Glu 
545                 550                 555                 560 


Glu Asn Lys Arg Lys Ile Ile Asp Glu Leu Phe Lys Glu Asn Lys Lys 
                565                 570                 575     


Val Ser Glu Lys Lys Phe Lys Glu Tyr Leu Leu Val Asn Gln Ile Ala 
            580                 585                 590         


Asn Arg Thr Val Glu Leu Lys Gly Ile Lys Asp Ser Phe Asn Ser Asn 
        595                 600                 605             


Tyr Val Ser Tyr Ile Lys Phe Lys Asp Ile Phe Gly Glu Lys Leu Asn 
    610                 615                 620                 


Leu Asp Ile Tyr Lys Glu Ile Ser Glu Lys Ser Ile Leu Trp Lys Cys 
625                 630                 635                 640 


Leu Tyr Gly Asp Asp Lys Lys Ile Phe Glu Lys Lys Ile Lys Asn Glu 
                645                 650                 655     


Tyr Gly Asp Ile Leu Asn Lys Asp Glu Ile Lys Lys Ile Asn Ser Phe 
            660                 665                 670         


Lys Phe Asn Thr Trp Gly Arg Leu Ser Glu Lys Leu Leu Thr Gly Ile 
        675                 680                 685             


Glu Phe Ile Asn Leu Glu Thr Gly Glu Cys Tyr Ser Ser Val Met Glu 
    690                 695                 700                 


Ala Leu Arg Arg Thr Asn Tyr Asn Leu Met Glu Leu Leu Ser Ser Lys 
705                 710                 715                 720 


Phe Thr Leu Gln Glu Ser Ile Asp Asn Gly Asn Lys Glu Met Asn Glu 
                725                 730                 735     


Val Ser Tyr Arg Asp Leu Ile Glu Glu Ser Tyr Val Ser Pro Ser Leu 
            740                 745                 750         


Lys Arg Ala Ile Leu Gln Thr Leu Lys Ile Tyr Glu Glu Ile Lys Lys 
        755                 760                 765             


Ile Thr Gly Arg Val Pro Lys Lys Val Phe Ile Glu Met Ala Arg Gly 
    770                 775                 780                 


Gly Asp Glu Thr Met Lys Asn Lys Lys Ile Pro Ala Arg Gln Glu Gln 
785                 790                 795                 800 


Leu Lys Lys Leu Tyr Asp Ser Cys Gly Asn Asp Ile Ala Asn Phe Ser 
                805                 810                 815     


Ile Asp Ile Lys Lys Met Lys Ser Ser Leu Ser Ser Tyr Asp Asn Asn 
            820                 825                 830         


Ser Leu Arg Gln Lys Lys Leu Tyr Leu Tyr Tyr Leu Gln Phe Gly Lys 
        835                 840                 845             


Cys Met Tyr Thr Gly Arg Glu Ile Asp Leu Asp Arg Leu Leu Gln Asn 
    850                 855                 860                 


Asn Asp Thr Tyr Asp Ile Asp His Ile Tyr Pro Arg Ser Lys Val Ile 
865                 870                 875                 880 


Lys Asp Asp Ser Phe Asp Asn Leu Val Leu Val Leu Lys Asn Glu Asn 
                885                 890                 895     


Ala Glu Lys Ser Asn Glu Tyr Pro Val Lys Lys Glu Ile Gln Glu Lys 
            900                 905                 910         


Met Lys Ser Phe Trp Arg Phe Leu Lys Glu Lys Asn Phe Ile Ser Asp 
        915                 920                 925             


Glu Lys Tyr Lys Arg Leu Thr Gly Lys Asp Asp Phe Glu Leu Arg Gly 
    930                 935                 940                 


Phe Met Ala Arg Gln Leu Val Asn Val Arg Gln Thr Thr Lys Glu Val 
945                 950                 955                 960 


Gly Lys Ile Leu Gln Gln Ile Glu Pro Glu Ile Lys Ile Val Tyr Ser 
                965                 970                 975     


Lys Ala Glu Ile Ala Ser Ser Phe Arg Glu Met Phe Asp Phe Ile Lys 
            980                 985                 990         


Val Arg Glu Leu Asn Asp Thr His  His Ala Lys Asp Ala  Tyr Leu Asn 
        995                 1000                 1005             


Ile Val  Ala Gly Asn Val Tyr  Asn Thr Lys Phe Thr  Glu Lys Pro 
    1010                 1015                 1020             


Tyr Arg  Tyr Leu Gln Glu Ile  Lys Glu Asn Tyr Asp  Val Lys Lys 
    1025                 1030                 1035             


Ile Tyr  Asn Tyr Asp Ile Lys  Asn Ala Trp Asp Lys  Glu Asn Ser 
    1040                 1045                 1050             


Leu Glu  Ile Val Lys Lys Asn  Met Lys Lys Asn Thr  Val Asn Ile 
    1055                 1060                 1065             


Thr Arg  Phe Ile Lys Glu Glu  Lys Gly Gln Leu Phe  Asp Leu Asn 
    1070                 1075                 1080             


Pro Ile  Lys Lys Gly Glu Thr  Ser Asn Glu Ile Ile  Ser Ile Lys 
    1085                 1090                 1095             


Pro Lys  Leu Tyr Asn Gly Lys  Glu Glu Lys Leu Asn  Glu Lys Tyr 
    1100                 1105                 1110             


Gly Tyr  Tyr Lys Ser Leu Asn  Pro Ala Tyr Phe Leu  Tyr Val Glu 
    1115                 1120                 1125             


His Lys  Glu Lys Asn Lys Arg  Ile Lys Ser Phe Glu  Arg Val Asn 
    1130                 1135                 1140             


Leu Val  Asp Val Asn Asn Ile  Lys Asp Glu Lys Ser  Leu Val Lys 
    1145                 1150                 1155             


Tyr Leu  Ile Glu Asn Lys Lys  Leu Val Glu Pro Arg  Leu Ile Lys 
    1160                 1165                 1170             


Lys Val  Tyr Lys Arg Gln Val  Ile Leu Ile Asn Asp  Tyr Pro Tyr 
    1175                 1180                 1185             


Ser Ile  Val Ala Leu Asp Ser  Asn Lys Leu Met Asp  Phe Glu Asn 
    1190                 1195                 1200             


Leu Lys  Pro Leu Phe Leu Glu  Asn Lys Tyr Glu Lys  Ile Leu Lys 
    1205                 1210                 1215             


Asn Val  Ile Lys Phe Leu Glu  Asp Asn Gln Gly Lys  Ser Glu Glu 
    1220                 1225                 1230             


Asn Tyr  Lys Phe Ile Tyr Leu  Lys Lys Lys Asp Arg  Tyr Glu Lys 
    1235                 1240                 1245             


Asn Glu  Thr Leu Glu Ser Val  Lys Asp Arg Tyr Asn  Leu Glu Phe 
    1250                 1255                 1260             


Asn Glu  Met Tyr Asp Lys Phe  Leu Glu Lys Leu Asp  Ser Lys Asp 
    1265                 1270                 1275             


Tyr Lys  Asn Tyr Ile Asn Asn  Lys Lys Tyr Lys Asn  Leu Leu Asp 
    1280                 1285                 1290             


Val Lys  Glu Lys Phe Ile Lys  Leu Asn Leu Phe Asp  Lys Ala Phe 
    1295                 1300                 1305             


Thr Leu  Lys Ser Phe Leu Asp  Leu Phe Asn Arg Lys  Thr Met Ala 
    1310                 1315                 1320             


Asp Phe  Ser Lys Val Gly Leu  Thr Lys Tyr Leu Gly  Lys Ile Gln 
    1325                 1330                 1335             


Lys Ile  Ser Ser Asn Val Leu  Ser Lys Asn Glu Leu  Tyr Leu Leu 
    1340                 1345                 1350             


Glu Glu  Ser Val Thr Gly Leu  Phe Val Lys Lys Ile  Lys Leu 
    1355                 1360                 1365         


<210> 236
<211> 1367
<212> PRT
<213> Fusobacterium sp.


<220>
<223> Fusobacterium sp. 3_1_36A2

<400> 236
Met Lys Lys Gln Lys Phe Ser Asp Tyr Tyr Leu Gly Phe Asp Ile Gly 
1               5                   10                  15      


Thr Asn Ser Val Gly Trp Cys Val Thr Asp Leu Asp Tyr Asn Val Leu 
            20                  25                  30          


Arg Phe Asn Lys Lys Asp Met Trp Gly Ser Arg Leu Phe Asp Glu Ala 
        35                  40                  45              


Lys Thr Ala Ala Glu Arg Arg Val Gln Arg Asn Ser Arg Arg Arg Leu 
    50                  55                  60                  


Lys Arg Arg Lys Trp Arg Leu Asn Leu Leu Glu Glu Ile Phe Ser Asp 
65                  70                  75                  80  


Glu Ile Met Lys Ile Asp Ser Asn Phe Phe Arg Arg Leu Lys Glu Ser 
                85                  90                  95      


Ser Leu Trp Leu Glu Asp Lys Asn Ser Lys Glu Lys Phe Thr Leu Phe 
            100                 105                 110         


Asn Asp Asp Asn Tyr Lys Asp Tyr Asp Phe Tyr Lys Gln Tyr Pro Thr 
        115                 120                 125             


Ile Phe His Leu Arg Asp Glu Leu Ile Lys Asn Pro Glu Lys Lys Asp 
    130                 135                 140                 


Ile Arg Leu Ile Tyr Leu Ala Leu His Ser Ile Phe Lys Ser Arg Gly 
145                 150                 155                 160 


His Phe Leu Phe Glu Gly Gln Asn Leu Lys Glu Ile Lys Asn Phe Glu 
                165                 170                 175     


Thr Leu Tyr Asn Asn Leu Ile Ser Phe Leu Glu Asp Asn Gly Ile Asn 
            180                 185                 190         


Lys Ser Ile Asp Lys Asp Asn Ile Lys Lys Leu Glu Lys Ile Ile Cys 
        195                 200                 205             


Asp Ser Gly Lys Gly Leu Lys Asp Lys Glu Lys Glu Phe Lys Glu Ile 
    210                 215                 220                 


Phe Asn Ser Asp Lys Gln Leu Val Ala Ile Phe Lys Leu Ser Val Gly 
225                 230                 235                 240 


Ser Ser Val Ser Leu Asn Asp Leu Phe Asp Thr Asp Glu Tyr Lys Lys 
                245                 250                 255     


Glu Glu Val Glu Lys Glu Lys Ile Ser Phe Arg Glu Gln Ile Tyr Glu 
            260                 265                 270         


Asp Asp Lys Pro Ile Tyr Tyr Ser Ile Leu Gly Glu Lys Ile Glu Leu 
        275                 280                 285             


Leu Asp Ile Ala Lys Ser Phe Tyr Asp Phe Met Val Leu Asn Asn Ile 
    290                 295                 300                 


Leu Ser Asp Ser Asn Tyr Ile Ser Glu Ala Lys Val Lys Leu Tyr Glu 
305                 310                 315                 320 


Glu His Lys Lys Asp Leu Lys Asn Leu Lys Tyr Ile Ile Arg Lys Tyr 
                325                 330                 335     


Asn Lys Glu Asn Tyr Asp Lys Leu Phe Lys Asp Lys Asn Glu Asn Asn 
            340                 345                 350         


Tyr Pro Ala Tyr Ile Gly Leu Asn Lys Glu Lys Gly Lys Lys Glu Val 
        355                 360                 365             


Val Glu Lys Ser Gly Leu Lys Ile Asp Asp Leu Ile Lys Val Ile Lys 
    370                 375                 380                 


Gly Tyr Leu Pro Lys Pro Glu Arg Ile Glu Glu Lys Asp Lys Thr Ile 
385                 390                 395                 400 


Phe Asn Glu Ile Leu Asn Lys Ile Glu Leu Lys Thr Ile Leu Pro Lys 
                405                 410                 415     


Gln Arg Ile Ser Asp Asn Gly Thr Leu Pro Tyr Gln Ile His Glu Val 
            420                 425                 430         


Glu Leu Glu Lys Ile Leu Glu Asn Gln Ser Lys Tyr Tyr Asp Phe Leu 
        435                 440                 445             


Asn Tyr Glu Glu Asn Gly Val Ser Thr Lys Asp Lys Leu Leu Lys Thr 
    450                 455                 460                 


Phe Lys Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Asn Ser Tyr His 
465                 470                 475                 480 


Lys Asp Lys Gly Gly Asn Ser Trp Ile Val Arg Lys Glu Glu Gly Lys 
                485                 490                 495     


Ile Leu Pro Trp Asn Phe Glu Gln Lys Val Asp Ile Glu Lys Ser Ala 
            500                 505                 510         


Glu Glu Phe Ile Lys Arg Met Thr Asn Lys Cys Thr Tyr Leu Asn Gly 
        515                 520                 525             


Glu Asp Val Ile Pro Lys Asp Ser Phe Leu Tyr Ser Glu Tyr Ile Ile 
    530                 535                 540                 


Leu Asn Glu Leu Asn Lys Val Gln Val Asn Asp Glu Phe Leu Asn Glu 
545                 550                 555                 560 


Glu Asn Lys Arg Lys Ile Ile Asp Glu Leu Phe Lys Glu Asn Lys Lys 
                565                 570                 575     


Val Ser Glu Lys Lys Phe Lys Glu Tyr Leu Leu Val Asn Gln Ile Ala 
            580                 585                 590         


Asn Arg Thr Val Glu Leu Lys Gly Ile Lys Asp Ser Phe Asn Ser Asn 
        595                 600                 605             


Tyr Val Ser Tyr Ile Lys Phe Lys Asp Ile Phe Gly Glu Lys Leu Asn 
    610                 615                 620                 


Leu Asp Ile Tyr Lys Glu Ile Ser Glu Lys Ser Ile Leu Trp Lys Cys 
625                 630                 635                 640 


Leu Tyr Gly Asp Asp Lys Lys Ile Phe Glu Lys Lys Ile Lys Asn Glu 
                645                 650                 655     


Tyr Gly Asp Ile Leu Asn Lys Asp Glu Ile Lys Lys Ile Asn Ser Phe 
            660                 665                 670         


Lys Phe Asn Thr Trp Gly Arg Leu Ser Glu Lys Leu Leu Thr Gly Ile 
        675                 680                 685             


Glu Phe Ile Asn Leu Glu Thr Gly Glu Cys Tyr Ser Ser Val Met Glu 
    690                 695                 700                 


Ala Leu Arg Arg Thr Asn Tyr Asn Leu Met Glu Leu Leu Ser Ser Lys 
705                 710                 715                 720 


Phe Thr Leu Gln Glu Ser Ile Asp Asn Gly Asn Lys Glu Met Asn Glu 
                725                 730                 735     


Val Ser Tyr Arg Asp Leu Ile Glu Glu Ser Tyr Val Ser Pro Ser Leu 
            740                 745                 750         


Lys Arg Ala Ile Leu Gln Thr Leu Lys Ile Tyr Glu Glu Ile Lys Lys 
        755                 760                 765             


Ile Thr Gly Arg Val Pro Lys Lys Val Phe Ile Glu Met Ala Arg Gly 
    770                 775                 780                 


Gly Asp Glu Thr Met Lys Asn Lys Lys Ile Pro Ala Arg Gln Glu Gln 
785                 790                 795                 800 


Leu Lys Lys Leu Tyr Asp Ser Cys Gly Asn Asp Ile Ala Asn Phe Ser 
                805                 810                 815     


Ile Asp Ile Lys Lys Met Lys Ser Ser Leu Ser Ser Tyr Asp Asn Asn 
            820                 825                 830         


Ser Leu Arg Gln Lys Lys Leu Tyr Leu Tyr Tyr Leu Gln Phe Gly Lys 
        835                 840                 845             


Cys Met Tyr Thr Gly Arg Glu Ile Asp Leu Asp Arg Leu Leu Gln Asn 
    850                 855                 860                 


Asn Asp Thr Tyr Asp Ile Asp His Ile Tyr Pro Arg Ser Lys Val Ile 
865                 870                 875                 880 


Lys Asp Asp Ser Phe Asp Asn Leu Val Leu Val Leu Lys Asn Glu Asn 
                885                 890                 895     


Ala Glu Lys Ser Asn Glu Tyr Pro Val Lys Lys Glu Ile Gln Glu Lys 
            900                 905                 910         


Met Lys Ser Phe Trp Arg Phe Leu Lys Glu Lys Asn Phe Ile Ser Asp 
        915                 920                 925             


Glu Lys Tyr Lys Arg Leu Thr Gly Lys Asp Asp Phe Glu Leu Arg Gly 
    930                 935                 940                 


Phe Met Ala Arg Gln Leu Val Asn Val Arg Gln Thr Thr Lys Glu Val 
945                 950                 955                 960 


Gly Lys Ile Leu Gln Gln Ile Glu Pro Glu Ile Lys Ile Val Tyr Ser 
                965                 970                 975     


Lys Ala Glu Ile Ala Ser Ser Phe Arg Glu Met Phe Asp Phe Ile Lys 
            980                 985                 990         


Val Arg Glu Leu Asn Asp Thr His  His Ala Lys Asp Ala  Tyr Leu Asn 
        995                 1000                 1005             


Ile Val  Ala Gly Asn Val Tyr  Asn Thr Lys Phe Thr  Glu Lys Pro 
    1010                 1015                 1020             


Tyr Arg  Tyr Leu Gln Glu Ile  Lys Glu Asn Tyr Asp  Val Lys Lys 
    1025                 1030                 1035             


Ile Tyr  Asn Tyr Asp Ile Lys  Asn Ala Trp Asp Lys  Glu Asn Ser 
    1040                 1045                 1050             


Leu Glu  Ile Val Lys Lys Asn  Met Lys Lys Asn Thr  Val Asn Ile 
    1055                 1060                 1065             


Thr Arg  Phe Ile Lys Glu Glu  Lys Gly Gln Leu Phe  Asp Leu Asn 
    1070                 1075                 1080             


Pro Ile  Lys Lys Gly Glu Thr  Ser Asn Glu Ile Ile  Ser Ile Lys 
    1085                 1090                 1095             


Pro Lys  Leu Tyr Asn Gly Lys  Glu Glu Lys Leu Asn  Glu Lys Tyr 
    1100                 1105                 1110             


Gly Tyr  Tyr Lys Ser Leu Asn  Pro Ala Tyr Phe Leu  Tyr Val Glu 
    1115                 1120                 1125             


His Lys  Glu Lys Asn Lys Arg  Ile Lys Ser Phe Glu  Arg Val Asn 
    1130                 1135                 1140             


Leu Val  Asp Val Asn Asn Ile  Lys Asp Glu Lys Ser  Leu Val Lys 
    1145                 1150                 1155             


Tyr Leu  Ile Glu Asn Lys Lys  Leu Val Glu Pro Arg  Leu Ile Lys 
    1160                 1165                 1170             


Lys Val  Tyr Lys Arg Gln Val  Ile Leu Ile Asn Asp  Tyr Pro Tyr 
    1175                 1180                 1185             


Ser Ile  Val Ala Leu Asp Ser  Asn Lys Leu Met Asp  Phe Glu Asn 
    1190                 1195                 1200             


Leu Lys  Pro Leu Phe Leu Glu  Asn Lys Tyr Glu Lys  Ile Leu Lys 
    1205                 1210                 1215             


Asn Val  Ile Lys Phe Leu Glu  Asp Asn Gln Gly Lys  Ser Glu Glu 
    1220                 1225                 1230             


Asn Tyr  Lys Phe Ile Tyr Leu  Lys Lys Lys Asp Arg  Tyr Glu Lys 
    1235                 1240                 1245             


Asn Glu  Thr Leu Glu Ser Val  Lys Asp Arg Tyr Asn  Leu Glu Phe 
    1250                 1255                 1260             


Asn Glu  Met Tyr Asp Lys Phe  Leu Glu Lys Leu Asp  Ser Lys Asp 
    1265                 1270                 1275             


Tyr Lys  Asn Tyr Ile Asn Asn  Lys Lys Tyr Lys Asn  Leu Leu Asp 
    1280                 1285                 1290             


Val Lys  Glu Lys Phe Ile Lys  Leu Asn Leu Phe Asp  Lys Ala Phe 
    1295                 1300                 1305             


Thr Leu  Lys Ser Phe Leu Asp  Leu Phe Asn Arg Lys  Thr Met Ala 
    1310                 1315                 1320             


Asp Phe  Ser Lys Val Gly Leu  Thr Lys Tyr Leu Gly  Lys Ile Gln 
    1325                 1330                 1335             


Lys Ile  Ser Ser Asn Val Leu  Ser Lys Asn Glu Leu  Tyr Leu Leu 
    1340                 1345                 1350             


Glu Glu  Ser Val Thr Gly Leu  Phe Val Lys Lys Ile  Lys Leu 
    1355                 1360                 1365         


<210> 237
<211> 1391
<212> PRT
<213> Galbibacter sp.


<220>
<223> Galbibacter sp. ck-I2-15

<400> 237
Met Lys Thr Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Lys Glu Ala Glu Asn Glu Asn Glu Val Ser Asp Ile Ile 
            20                  25                  30          


Lys Leu Gly Val Arg Val Asn Pro Leu Thr Val Asp Glu Leu Thr Asn 
        35                  40                  45              


Phe Glu Gly Gly Lys Ala Tyr Ser Asn Asn Ala Glu Arg Thr Leu Lys 
    50                  55                  60                  


Arg Gly Ala Arg Arg Asn Leu Gln Arg Tyr Lys Leu Arg Arg Glu Asn 
65                  70                  75                  80  


Leu Ile Glu Ile Leu Leu Lys Asn Gly Leu Ile Asn Lys Asp Thr Ala 
                85                  90                  95      


Leu Thr Glu Val Gly Lys Glu Thr Thr His Gln Thr Leu Lys Leu Arg 
            100                 105                 110         


Ser Lys Ser Ala Asn Glu Lys Val Ser Leu Glu Asp Leu Ala Lys Ile 
        115                 120                 125             


Leu Leu Ser Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Val 
    130                 135                 140                 


Asn Ala Glu Asp Asp Gly Val Ala Ile Asp Gly Met Glu Val Ala Lys 
145                 150                 155                 160 


Leu Leu Tyr Asp Glu Asn Met Thr Pro Gly Glu Tyr Val Leu Arg Leu 
                165                 170                 175     


Leu Glu Ser Gly Lys Lys His Leu Pro Asp Phe Tyr Arg Ser Asp Leu 
            180                 185                 190         


Gln Glu Glu Phe Asn Leu Val Trp Lys Lys Gln Ser Glu Phe Tyr Pro 
        195                 200                 205             


Leu Ile Leu Thr Lys Glu Leu Phe Phe Glu Leu His Gly Lys Asn Lys 
    210                 215                 220                 


Ser Gln Thr Trp Ala Ile Cys Lys Glu Pro Leu Gly Ile Val Gly Val 
225                 230                 235                 240 


Lys Leu Lys Gly Ser Ala Lys Glu Gln Lys Phe Ala Arg Tyr Arg Leu 
                245                 250                 255     


Arg Lys Glu Ala Leu Thr Gln Gln Ile Glu Leu Glu His Leu Ala Ile 
            260                 265                 270         


Val Leu Gln Asp Ile Asn Asn Asp Ser Asn Lys Ser Ser Gly Tyr Leu 
        275                 280                 285             


Gly Ala Ile Ser Asp Arg Ser Lys Glu Leu Phe Phe Asn Lys Glu Thr 
    290                 295                 300                 


Val Gly Gln Tyr Gln Tyr Lys Gln Leu Gln Lys Asp Pro Asn Thr Ser 
305                 310                 315                 320 


Leu Lys Asn Gln Val Phe Tyr Arg Gln Asp Tyr Leu Asp Glu Phe Glu 
                325                 330                 335     


Val Ile Trp Arg Asn Gln Ala Lys Phe Tyr Pro Gln Leu Thr Asn Glu 
            340                 345                 350         


Leu Lys Gln Glu Ile Arg Asp Val Val Ile Phe Tyr Gln Arg Lys Leu 
        355                 360                 365             


Lys Ser Gln Lys Asn Leu Ile Ser Phe Cys Gln Phe Glu Ser Thr Gln 
    370                 375                 380                 


Gln Asn Tyr Val Glu Lys Glu Thr Gly Lys Thr Lys Ile Arg Thr Ile 
385                 390                 395                 400 


Gly Arg Arg Val Ile Pro Arg Ser Ser Pro Leu Phe Gln Glu Phe Lys 
                405                 410                 415     


Ile Trp Gln Ser Leu Asn Asn Leu Lys Phe Val Asn Ser Glu Ser Asn 
            420                 425                 430         


Gln Ile Ile Gln Phe Ile Glu Leu Glu Asp Asp Val Lys Lys Val Val 
        435                 440                 445             


Phe Asp Glu Leu Asn Leu Arg Gly Asp Leu Lys Pro Asn Gln Val Leu 
    450                 455                 460                 


Lys Ile Leu Ser Lys Tyr Met Lys Ile Gly Lys Leu Thr Gln Trp Lys 
465                 470                 475                 480 


Cys Asn Leu Glu Glu Ile Glu Gly Asn Arg Thr Asn Ser Ala Leu Tyr 
                485                 490                 495     


Asn Val Phe Gln Met Ile Ala Glu Glu Glu Gly Tyr Gly Phe Asn Trp 
            500                 505                 510         


Gly Lys Lys Ser Ala Leu Glu Ile Lys Ser Glu Leu Lys Ala Ile Phe 
        515                 520                 525             


Ser Ser Ile Gly Ile Asn Asp Ser Ile Leu Asp Phe Asp Phe Ser Lys 
    530                 535                 540                 


Lys Leu Asp Gln Gln Leu Ser Tyr Gln Leu Trp His Leu Leu Tyr Ser 
545                 550                 555                 560 


Ala Glu Glu Gly Asn Ser Lys Ile Thr Glu Glu Asp Lys Phe Thr Tyr 
                565                 570                 575     


Gly Asn Thr Gly Val Ala Leu Lys Lys Lys Leu His Leu Lys Phe Gly 
            580                 585                 590         


Phe Lys Pro Glu Tyr Ser Thr Leu Ile Ser Asn Leu Arg Phe Thr Ser 
        595                 600                 605             


Asp Tyr Gly Asn Leu Ser Ser Lys Ala Ile Ser Lys Ile Leu Pro Phe 
    610                 615                 620                 


Leu Arg Asp Gly Ser Asp Tyr Ser Lys Ala Cys Gln Tyr Ala Gly Tyr 
625                 630                 635                 640 


Asn His Ser Asn Ser Leu Ser Ala Asp Glu Leu Asp Asn Arg Glu Leu 
                645                 650                 655     


Lys Pro Lys Leu Glu Leu Leu Lys Lys Asn Ser Leu Arg Asn Pro Val 
            660                 665                 670         


Val Glu Lys Ile Leu Asn Gln Met Val Asn Val Val Asn Gln Val Ile 
        675                 680                 685             


Asp Asn Tyr Gly Lys Pro Asp Glu Val Arg Ile Glu Leu Ala Arg Glu 
    690                 695                 700                 


Leu Lys Lys Ser Ala Lys Glu Arg Ser Gln Met Thr Lys Asn Ile Ser 
705                 710                 715                 720 


Asp Ala Thr Arg Arg Asn Ala Glu Ile Lys Lys Tyr Leu Ser Lys Glu 
                725                 730                 735     


Phe Gly Ile Pro Asn Pro Thr Lys Gly Asp Val Ile Arg Tyr Arg Leu 
            740                 745                 750         


Trp Glu Glu Leu Ala Ser Asn Gly Tyr Lys Asp Leu Phe Arg Asp Lys 
        755                 760                 765             


Tyr Ile Pro Lys Glu Lys Leu Phe Ser Asn Glu Ile Asp Ile Glu His 
    770                 775                 780                 


Ile Ile Pro Lys Ala Leu Leu Phe Asp Asp Ser Phe Ser Asn Lys Thr 
785                 790                 795                 800 


Leu Ala Phe Lys Val Asp Asn Leu Lys Lys Ala Asp Arg Thr Ala Phe 
                805                 810                 815     


Asp Phe Met Ser Thr Asp Phe Ser Lys Asp Val Asp Ser Tyr Ile Gly 
            820                 825                 830         


Arg Ile Glu Thr Leu His Lys Asp Gly Lys Ile Ser Ser Ser Lys Tyr 
        835                 840                 845             


Lys Lys Leu Met Ile Pro Lys Ser Lys Leu Val Asp Gly Phe Ile Glu 
    850                 855                 860                 


Arg Asp Leu Arg Asn Thr Gln Tyr Ile Ala Lys Gln Ala Arg Lys Met 
865                 870                 875                 880 


Leu Leu Glu Val Phe Lys Thr Val Val Pro Thr Thr Gly Lys Ile Thr 
                885                 890                 895     


Asp Lys Leu Arg Glu Asp Trp Asp Leu Ile Asn Val Met Lys Glu Leu 
            900                 905                 910         


Asn Phe Pro Lys Tyr Lys Ala Leu Gly Leu Thr Lys Lys Ile Glu Arg 
        915                 920                 925             


Phe Asp Val Gly Ser Glu Lys Ile Lys Ser Ile Asn Val Ile Glu Gly 
    930                 935                 940                 


Trp Ser Lys Arg Asn Asp His Arg His His Ala Met Asp Ala Leu Ala 
945                 950                 955                 960 


Val Ala Phe Thr Thr His Asn His Ile Gln Tyr Leu Asn Tyr Leu Asn 
                965                 970                 975     


Ala Arg Lys Asp Ile His His Glu Met His Gly Thr Ile Lys Ser Ile 
            980                 985                 990         


Glu Asn Gln Ile Ile Gly Lys Asp  Val Met Gly Lys Arg  Arg Phe Ile 
        995                 1000                 1005             


Pro Pro  Ile Ser Asp Leu Arg  Met Lys Ala Lys Leu  Gln Ile Glu 
    1010                 1015                 1020             


Ser Ile  Leu Ile Ser Phe Lys  Asn Lys Asn Lys Val  Val Thr Trp 
    1025                 1030                 1035             


Ser Val  Asn Lys Thr Lys Leu  Lys Gly Lys Asp Asn  Tyr Asn Lys 
    1040                 1045                 1050             


Arg Arg  Gln Leu Thr Pro Arg  Gly Gln Leu His Lys  Glu Thr Val 
    1055                 1060                 1065             


Tyr Gly  Lys Ile Lys Leu Ile  Asp Pro Lys Pro Leu  Lys Leu Asn 
    1070                 1075                 1080             


Asn Lys  Phe Thr Leu Val Arg  Ala Ser Met Ile Val  Asp Lys Val 
    1085                 1090                 1095             


His Arg  Glu Ile Val Leu Gln  His Leu Ser Lys Tyr  Asp Asn Asn 
    1100                 1105                 1110             


Ser Glu  Val Ala Phe Asp Ser  Lys Thr Ile Lys Ile  Asp Pro Ile 
    1115                 1120                 1125             


Leu Ile  Glu Gly Ile Gly Leu  Lys Glu Val Val Cys  Tyr Glu Asp 
    1130                 1135                 1140             


Val Phe  Lys Ile Arg Lys Lys  Ile Ser Gly Asp Asn  Phe Lys Asn 
    1145                 1150                 1155             


Glu Lys  His Leu Glu Lys Val  Ile Asp Glu Lys Val  Lys Gln Ile 
    1160                 1165                 1170             


Leu Lys  Asp Arg Val Ile Lys  Phe Gln Gly Asn Phe  Lys Glu Ala 
    1175                 1180                 1185             


Phe Ser  Asn Leu Glu Glu Asn  Pro Ile Trp Leu Asn  Lys Ser Lys 
    1190                 1195                 1200             


Gly Ile  Ala Val Lys Ser Val  Ala Ile Lys Gly Val  Asn Asn Ala 
    1205                 1210                 1215             


Glu Ser  Leu His Glu Gly Lys  Asp His Phe Gly Asp  Gln Ile Leu 
    1220                 1225                 1230             


Asp Lys  Asn Lys Lys Gln Ile  Pro Val Asp Phe Val  Ser Thr Gly 
    1235                 1240                 1245             


Asn Asn  His His Val Gly Ile  Tyr Glu Asp Lys Asp  Gly Asn Leu 
    1250                 1255                 1260             


Gln Glu  Arg Val Val Ser Phe  Phe Glu Ala Val Thr  Arg Val Asn 
    1265                 1270                 1275             


Glu Gly  Leu Pro Ile Ile Asp  Lys Thr Tyr Asn Ser  Asp Ile Gly 
    1280                 1285                 1290             


Trp Lys  Phe Lys Phe Thr Met  Lys Gln Asn Glu Met  Phe Val Phe 
    1295                 1300                 1305             


Pro Ser  Asp Asp Phe Asp Pro  Asn Glu Phe Asp Leu  Thr Asp Gly 
    1310                 1315                 1320             


Lys Asn  Ala Ala Lys Ile Ser  Pro Asn Leu Tyr Arg  Val Gln Lys 
    1325                 1330                 1335             


Ile Ala  Thr Lys Asn Tyr Met  Phe Arg His His Leu  Glu Thr Val 
    1340                 1345                 1350             


Val Thr  Asn Asp Leu Glu Phe  Thr Tyr Lys Ser Ile  Arg Ser Thr 
    1355                 1360                 1365             


Gly Trp  Leu Arg Asn Leu Val  Lys Val Arg Ile Asn  His Leu Gly 
    1370                 1375                 1380             


Glu Ile  Val Tyr Val Gly Glu  Tyr 
    1385                 1390     


<210> 238
<211> 1025
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      gamma proteobacterium HdN1 polypeptide

<400> 238
Met Gly Gly Tyr Met Pro Gln Leu Met Arg Tyr Arg Leu Ala Leu Asp 
1               5                   10                  15      


Ile Gly Ser Thr Ser Ile Gly Trp Ala Met Ile Arg Leu Ser Met Gln 
            20                  25                  30          


Asn Glu Pro Ile Ala Ile Ile Arg Met Gly Val Arg Ile Phe Ser Asp 
        35                  40                  45              


Gly Arg Asn Pro Lys Asp Gly Ser Ser Leu Ala Val Thr Arg Arg Val 
    50                  55                  60                  


Ala Arg Gln Met Arg Arg Arg Arg Asp Arg Leu Leu Lys Arg Lys Thr 
65                  70                  75                  80  


Arg Leu Leu Asn Ala Leu Val Gln Lys Lys Phe Phe Pro Glu Asp Ala 
                85                  90                  95      


Asp Ala Arg Lys Ala Leu Val Val Leu Asn Pro Tyr Glu Leu Arg Lys 
            100                 105                 110         


Glu Gly Leu Tyr Arg Gln Leu Ser Gly Pro Glu Phe Gly Arg Ala Leu 
        115                 120                 125             


Phe His Ile Ser Gln Arg Arg Gly Phe Leu Ser Asn Arg Lys Thr Asp 
    130                 135                 140                 


Lys Lys Asp Asn Asp Ser Ser Val Leu Lys Lys Ala Ile Val Asp Leu 
145                 150                 155                 160 


Arg Gln Gln Leu Glu Val Glu Asn Cys Gln Thr Ile Gly Glu Trp Leu 
                165                 170                 175     


Phe Lys Gln Gln Gln Ser Gly Lys Ser Val Arg Ala Arg Leu Arg Gly 
            180                 185                 190         


Lys Thr Gln Lys Asp Lys Ala Tyr Asp Phe Tyr Ile Asp Arg Ala Met 
        195                 200                 205             


Ile Ala His Glu Phe Asp Thr Leu Trp Val Ser Gln Ala Lys Tyr Asp 
    210                 215                 220                 


Pro Leu Leu Phe Asn Glu Asp Ala Arg Ala Ile Leu Arg Asp Ile Leu 
225                 230                 235                 240 


Leu Tyr Gln Arg Pro Leu Lys Pro Val Lys Pro Gly Arg Cys Thr Leu 
                245                 250                 255     


Ile Pro Asp Glu Ser Arg Ala Pro Leu Ala Leu Pro Leu Thr Gln Gln 
            260                 265                 270         


Ala Arg Ile Tyr Gln Glu Leu Asn His Leu Arg Ile Thr Thr Pro Ala 
        275                 280                 285             


Leu Gly Ala Gln Ala Leu Thr Val Ala Gln Arg Asn Thr Ile Ala Ala 
    290                 295                 300                 


Leu Leu Glu Lys Ser Asp Val Thr Phe Val Lys Ile Ala Lys Ala Leu 
305                 310                 315                 320 


Gly Leu Thr Ser Thr Thr Glu Phe Asn Leu Gln Asp Ile Lys Arg Asp 
                325                 330                 335     


Arg Leu Lys Gly Asn Ala Thr Ala Ile Ile Leu Ala Arg Asn Gln Tyr 
            340                 345                 350         


Phe Gly Arg Arg Trp His Asp Phe Asn Ala Asp Leu Gln Asn Leu Ile 
        355                 360                 365             


Val Asp Lys Leu Val Asn Glu Gly Ser Glu Thr Ala Leu Ile Glu Trp 
    370                 375                 380                 


Leu Lys Ala Asn Thr Asp Val Asp Glu Ser Ala Ala Glu Arg Val Ser 
385                 390                 395                 400 


Gly Val Thr Leu Pro Glu Gly Tyr Gly Ser Leu Ser Val Ala Ala Leu 
                405                 410                 415     


Arg Arg Leu Leu Pro Ala Leu Lys Glu Asp Val Val Val Tyr Ser Glu 
            420                 425                 430         


Ala Val Lys Arg Ala Gly Phe Asp Ser His Ser Ala Leu Ser Leu Ile 
        435                 440                 445             


Glu Gln Thr Gly Glu Leu Tyr Gln Glu Leu Pro Tyr Tyr Gly Glu Val 
    450                 455                 460                 


Leu Gln Arg His Val Gly Phe Gly Ser Gly Asp Pro Asn Asp Ser Pro 
465                 470                 475                 480 


Glu Arg Arg Phe Gly Lys Ile Ala Asn Pro Thr Val His Ile Gly Leu 
                485                 490                 495     


Asn Glu Leu Arg Lys Ile Ile Asn Ala Leu Ile Lys Arg Tyr Gly Asn 
            500                 505                 510         


Pro Ala Glu Val Val Val Glu Leu Ala Arg Asp Leu Lys Leu Ser Arg 
        515                 520                 525             


Glu Lys Arg Lys Glu Ile Gln Glu Glu Gln Lys Gln Arg Gln Asp Arg 
    530                 535                 540                 


Asn Glu Lys Arg Ile Lys Asp Ala Cys Glu Ile Leu Gly Ile Asp Pro 
545                 550                 555                 560 


Leu Val Ile Asp Arg Gly Lys Arg Arg Glu Ile Ser Gln Lys Met Gln 
                565                 570                 575     


Leu Trp Asp Glu Leu Asn Pro Lys Asp Ala Ala Asn Arg Arg Cys Pro 
            580                 585                 590         


Tyr Thr Gly Asp Gln Ile Ser Ile Glu Lys Leu Leu Ser Ala Glu Val 
        595                 600                 605             


Glu Ile Glu His Ile Leu Pro Phe Ser Lys Thr Leu Asp Asp Ser Leu 
    610                 615                 620                 


Asn Asn Lys Thr Val Ala Met Arg Arg Ala Asn Arg Asp Lys Gly Asn 
625                 630                 635                 640 


Arg Thr Pro Tyr Glu Ala Phe Gly Glu Ser Leu Asn Pro Asp Tyr Asp 
                645                 650                 655     


Tyr Asp Ala Ile Leu Gln Arg Ala Ser Leu Met Pro Arg Glu Lys Arg 
            660                 665                 670         


Lys Arg Phe Ala Ser Asp Gly Tyr Gln Gln Trp Leu Arg Asp Asp Lys 
        675                 680                 685             


Asp Phe Leu Ser Arg Ala Leu Asn Asp Thr Ala Tyr Leu Ser Arg Ile 
    690                 695                 700                 


Ala Lys Glu Tyr Leu Thr Leu Ile Cys Pro Pro Asn Ser Val Arg Ala 
705                 710                 715                 720 


Ile Pro Gly Arg Met Thr Ala Gln Leu Arg Ala Met Phe Gly Leu Asn 
                725                 730                 735     


Arg Leu Leu Ser Glu Gly Gly Ile Lys Asn Arg Glu Asp His Arg His 
            740                 745                 750         


His Ala Ile Asp Ala Ala Val Ile Gly Val Thr Asp Gln Gly Leu Leu 
        755                 760                 765             


Gln Lys Phe Ser Arg Ala Ser Ala Arg Thr Arg Glu Leu Gln Leu Ser 
    770                 775                 780                 


Arg Leu Val Asp Asp Met Pro Leu Pro Trp Asp Thr Tyr Arg Glu His 
785                 790                 795                 800 


Val Thr Arg Ala Leu Glu His Leu Val Val Ser His Lys Pro Asp His 
                805                 810                 815     


Gly Tyr Gln Gly Lys Met His Glu Asp Thr Ala Trp Gly Leu Arg Asp 
            820                 825                 830         


Asn Gly Gln Val Thr Arg Arg Val Arg Ser Glu Asp Gly Gly Pro Arg 
        835                 840                 845             


Gln Arg Leu Leu Glu Asn Lys Asn Val Val Lys Ile Asn Ser Thr Arg 
    850                 855                 860                 


Asp Phe Ser Arg His Gly Ile Asp Glu Gln Gly Gln Val Asn Ala Tyr 
865                 870                 875                 880 


Lys Gly Tyr Val Gly Gly Ser Asn Tyr Cys Ile Glu Ile Trp Ile Asp 
                885                 890                 895     


Glu Lys Gly Lys Trp Asn Ser Asp Val Val Ser Thr Phe Gln Ala Tyr 
            900                 905                 910         


Gln Ile Val Arg Glu Leu Gly Glu Lys Ala Ala Trp Gln Lys Leu Arg 
        915                 920                 925             


Asn Pro Leu Leu Ser Leu Ser Ala Lys Pro Leu Val Met Arg Leu Ile 
    930                 935                 940                 


Ile Asp Asp Val Val Lys Met Gln Ile Ala Gly Gln Asn Lys Ile Met 
945                 950                 955                 960 


Arg Val Val Lys Ile Ala Gln Asn Gly Gln Ile Phe Phe Ala Glu His 
                965                 970                 975     


Asn Glu Ala Asn Val Asp Ala Arg Asp Lys Asp Lys Asn Asn Pro Phe 
            980                 985                 990         


Lys Tyr Ile Ser Lys Thr Ala Gly  Ser Leu Gln Lys Ala  Gly Gly Ile 
        995                 1000                 1005             


His Met  Ala Ile Ser Pro Ile  Gly Asp Ala Arg Pro  Val Arg Tyr 
    1010                 1015                 1020             


Gly Arg  
    1025 


<210> 239
<211> 1397
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      gamma proteobacterium HTCC5015 polypeptide

<400> 239
Met Thr Lys Asn Tyr Ile Ser Pro Ile Ala Ile Asp Leu Gly Ala Lys 
1               5                   10                  15      


Phe Thr Gly Val Ala Leu Tyr Gln Tyr Leu Glu Gly Ala Asp Cys Thr 
            20                  25                  30          


Gln Glu Val Ala Lys Gly Leu Leu Val Asp Asp Arg Gly Asn Val Thr 
        35                  40                  45              


Trp Ser Gln Glu Gly Arg Arg Gly Lys Arg His Gln Val Arg Gly Tyr 
    50                  55                  60                  


Lys Arg Arg Lys Met Ala Lys Arg Leu Leu Trp Leu Ile Leu Asp Ser 
65                  70                  75                  80  


Glu Tyr Gly Ile Lys Arg Glu Glu Val Thr Glu Pro Leu Leu Lys Phe 
                85                  90                  95      


Ile Asn Gly Leu Leu Asn Arg Arg Gly Tyr Thr Tyr Ile Ser Glu Glu 
            100                 105                 110         


Val Asp Glu Glu Ser Met Asn Val Ser Pro Leu Pro Phe Ser Glu Met 
        115                 120                 125             


Met Pro Asp Tyr Phe Asn Ser Ser Ala Pro Leu Leu Glu Gln Leu Ala 
    130                 135                 140                 


Lys Leu Leu Ser Asp Lys Asn Lys Leu Val Arg Phe Arg Ala Glu Gly 
145                 150                 155                 160 


Lys Ile Pro Ser Asn Lys Asn Glu Phe Lys Lys Leu Leu Asp Thr Ala 
                165                 170                 175     


Leu Asp Gly Lys Tyr Lys Asp Glu Lys Lys Glu Leu Ser Glu Ala Trp 
            180                 185                 190         


Gly Asn Ile Leu Ile Ala Ser Glu Asn Val Leu Lys Ser Thr Val Asp 
        195                 200                 205             


Gly His Lys Ser Arg Ser Glu Tyr Leu Ala Asn Ile Lys Glu Asp Ile 
    210                 215                 220                 


Lys Ser Asn Glu Glu Leu Glu Lys Gln Ile Ser Ser Lys Glu Ile Asp 
225                 230                 235                 240 


Gly Phe Tyr Asn Leu Val Gly His Leu Ser Asn Phe Gln Leu Arg Leu 
                245                 250                 255     


Leu Arg Lys Tyr Phe Asn Asp Pro Asn Met Ser Gly Val Ser Tyr Trp 
            260                 265                 270         


Asp Glu Lys Arg Leu Glu Lys Tyr Phe Tyr Gln Trp Val Gln Gly Trp 
        275                 280                 285             


His Thr Lys Gly Gly Thr Asp Glu Ala Glu Lys Lys Asn Ile Ile Leu 
    290                 295                 300                 


Lys Thr Lys Gly Ala Pro Leu Leu Lys Thr Leu Lys Ser Leu Ser Ala 
305                 310                 315                 320 


Asp Leu Thr Ile Pro Pro Tyr Glu Asp Gln Asn Asn Arg Arg Pro Pro 
                325                 330                 335     


Lys Cys Gln Ser Val Leu Leu Ser Asp Glu Lys Leu Thr Met His Tyr 
            340                 345                 350         


Pro Lys Trp Lys Glu Trp Val Gly Gln Leu Val Lys Gln Asn Asp Asn 
        355                 360                 365             


Ala Tyr Leu Asn Glu Asn Val Thr Leu Ala Asn Ala Leu His Arg Ile 
    370                 375                 380                 


Val Glu Arg Ser Arg Ser Ile Asp Pro Tyr Gln Leu Arg Leu Leu Ile 
385                 390                 395                 400 


Ser Ile Thr Asp Ala Glu Lys Arg Asn Asp Leu Ala Gly Tyr Lys Arg 
                405                 410                 415     


Leu Lys Leu Ser Leu Gly Ser Glu Val Asp Glu Phe Leu Leu Leu Val 
            420                 425                 430         


Lys Asn Ile Val Asp Glu Thr Lys Glu Ala Arg Glu Gly Leu Trp Phe 
        435                 440                 445             


Glu Thr Glu Asn Lys Leu Phe Phe Lys Cys Gly Lys Thr Pro Pro Arg 
    450                 455                 460                 


Lys Glu Lys Leu Lys Ser Thr Leu Leu Ser Ala Val Leu Gly Lys Asn 
465                 470                 475                 480 


Leu Ser Asp Asp Glu Gln Ser Ser Phe Ile Glu Glu Phe Trp Lys Ser 
                485                 490                 495     


Gly Thr Pro Lys Ile Glu Arg Arg Asn Val Arg Gly Trp Cys Arg Leu 
            500                 505                 510         


Ala Ser Gln Val Gln Lys Thr Tyr Gly Val Tyr Leu Lys Glu Tyr Gly 
        515                 520                 525             


Leu Gln Gln Leu His Lys Leu Glu Ala Gly Lys Lys Leu Asp Asp Lys 
    530                 535                 540                 


Pro Leu Ala Leu Leu Tyr Lys Asn Ser Gly Leu Ile Ala Ser Lys Ile 
545                 550                 555                 560 


Gly Glu Ala Leu Asn Ile Glu Pro Asp Glu Val Ser Arg Phe Ala Ser 
                565                 570                 575     


Pro His Ser Leu Ala Gln Ile Phe Asn Ile Ile Glu Gly Asp Val Ala 
            580                 585                 590         


Gly Phe Asn Lys Thr Cys Arg Ala Cys Thr Tyr Glu Asn Ile Trp Arg 
        595                 600                 605             


Met Gln Glu Glu Lys Val Glu Ser Leu Leu Thr Asn Gln Leu Leu Ser 
    610                 615                 620                 


Glu Ile His Gly Glu Arg Lys Val Pro Leu Lys Ser Ala Met Cys Thr 
625                 630                 635                 640 


Arg Leu Ser Ala Asp Ser Thr Arg Pro Phe Asp Gly Gln Met Ala Ser 
                645                 650                 655     


Ile Ile Glu His Ile Ala Arg Lys Ile Ala Gln His Lys Ile Ala Gln 
            660                 665                 670         


Ile Asn Asp Val Pro Lys Glu Phe Ser Ile Asp Ile Pro Ile Ile Ile 
        675                 680                 685             


Glu Ser Asn Gln Phe Ser Phe Thr Ala Glu Leu Glu Glu Ile Lys Arg 
    690                 695                 700                 


Gly Arg Gly Ser Ala Lys Ala Lys Lys Ala Lys Glu Leu Gly Glu Lys 
705                 710                 715                 720 


Ser Lys Ala Gly Trp Val Ser Lys Thr Glu Arg Ile Lys Thr Ser Ser 
                725                 730                 735     


Glu Gly Ile Cys Pro Tyr Thr Gly Ala Pro Leu Gly Gly Ser Gly Glu 
            740                 745                 750         


Ile Asp His Ile Ile Pro Arg Ser Leu Thr Gly Arg Thr Lys Lys Thr 
        755                 760                 765             


Val Phe Asn Ser Glu Ala Asn Leu Ile Tyr Cys Ser Ser Lys Gly Asn 
    770                 775                 780                 


His Asp Lys Gly Asn Arg Val Tyr Val Ile Glu Gln Leu Asn Asp Lys 
785                 790                 795                 800 


Tyr Leu Lys Lys Gln Phe Ser Thr Ser Asp Val Asn Leu Ile Lys Lys 
                805                 810                 815     


Lys Ile Lys Thr Thr Ile Gln Arg Phe Thr Glu Gly Gly Glu Lys Leu 
            820                 825                 830         


Arg Ser Phe Ser Glu Leu Ser Arg Glu Asp Gln Lys Ala Phe Arg His 
        835                 840                 845             


Ala Leu Phe Val Pro Glu Leu Lys Ser Glu Val Thr Ser Leu Leu Ala 
    850                 855                 860                 


Val Lys Asn Ile Thr Arg Val Asn Gly Thr Gln Ala Trp Leu Ala Lys 
865                 870                 875                 880 


Lys Ile Ala Ser Leu Leu Ala Glu His Leu Asp Lys Gln Gly Arg Asp 
                885                 890                 895     


Tyr Thr Leu Ser Ala His Gln Ile Asp Pro Trp Ser Val Ser Lys Gln 
            900                 905                 910         


Arg Lys Met Leu Ala Ser Ala Glu Pro Ile Trp Ala Lys Lys Asp Pro 
        915                 920                 925             


Gln Pro Ala Ala Ser His Val Val Asp Ala Val Cys Thr Phe Leu Glu 
    930                 935                 940                 


Ala Leu Glu Gln Pro His Thr Ala Ser Arg Leu Lys Thr Ile Ser Ser 
945                 950                 955                 960 


Thr Ser Phe Glu Lys Thr Gly Trp Arg Ser Ala Leu Ile Pro Asp Leu 
                965                 970                 975     


Ile Lys Val Asp Ala Leu Asp Arg Arg Pro Lys Tyr Arg Arg Tyr Asn 
            980                 985                 990         


Ile Gly Ser Thr Ser Leu Phe Lys  Asp Gly Ile Tyr Ala  Glu Arg Phe 
        995                 1000                 1005             


Leu Pro  Ile Leu Ile Asp Glu  Asn Gly Leu Met Ala  Gly Tyr Asp 
    1010                 1015                 1020             


Ile Asp  Asn Ser Leu Lys Ala  Lys Gly Ala Asp Val  Val Phe Glu 
    1025                 1030                 1035             


Ser Leu  Ser Pro Phe Leu Leu  Phe Lys Gly Glu Glu  Val Gly Ala 
    1040                 1045                 1050             


Gln Ser  Leu Ser Asp Trp Gln  Glu Arg Ile Asp Gly  Arg Tyr Leu 
    1055                 1060                 1065             


Tyr Met  Ser Ile Asp Lys Val  Lys Ala Phe Asp Tyr  Leu Gln Glu 
    1070                 1075                 1080             


Lys Val  Gly Glu Lys Asp Ile  Ala Ala Glu Leu Leu  Asn Ser Ile 
    1085                 1090                 1095             


His Phe  Thr Gln Arg Lys Thr  Glu Leu Arg Ala Lys  Phe Ser Asp 
    1100                 1105                 1110             


Asp Ser  Gly Lys Lys Met Lys  Thr Leu Asp Ala Ile  Arg Lys Ser 
    1115                 1120                 1125             


Leu Lys  Leu Thr Val Thr Val  Asn Glu Ile Gly Lys  Arg Lys Glu 
    1130                 1135                 1140             


Lys Cys  Gly Phe Ser Gly Thr  Ile Gly Ile Pro Ala  Lys Ser Ala 
    1145                 1150                 1155             


Trp Glu  Asn Leu Leu Asp Glu  Pro Leu Leu Glu Thr  Tyr Trp Gly 
    1160                 1165                 1170             


Thr Lys  Met Pro Pro Gln Glu  Ile Trp Glu Lys Val  Tyr Arg Lys 
    1175                 1180                 1185             


His Phe  Pro Arg Asn Ile Pro  Asn Gln Ala His Arg  Lys Val Arg 
    1190                 1195                 1200             


Lys Asp  Phe Ser Leu Pro Val  Val Asp Ser Val Ser  Gly Gly Phe 
    1205                 1210                 1215             


Arg Val  Lys Arg Lys Thr Pro  Asn Gly Tyr Asn Tyr  Gln Leu Leu 
    1220                 1225                 1230             


Ala Ile  Asp Gly Tyr Ser Ala  Val Gly Phe Lys Lys  Glu Gly Asp 
    1235                 1240                 1245             


Asn Val  Asp Phe Lys Ser Pro  Ala Leu Val Pro Gln  Ile Ala Glu 
    1250                 1255                 1260             


Ser Lys  Ser Val Thr Pro Ile  Ser Ser Glu Leu Val  His Leu Asp 
    1265                 1270                 1275             


Lys Asn  Glu Ile Val Tyr Phe  Asp Glu Trp Arg Lys  Ile Asp Ile 
    1280                 1285                 1290             


Ser Asp  Ser Asp Leu Lys Gln  Phe Val Ser Ser Leu  Glu Leu Ala 
    1295                 1300                 1305             


Pro Gly  Ser Gln Asn Arg Phe  Tyr Ile Arg Phe Thr  Val Asp Glu 
    1310                 1315                 1320             


Asp Gln  Phe Glu Arg His Phe  Lys Ser Ala Leu Arg  Val Asn Gly 
    1325                 1330                 1335             


Ile Gln  Asp Leu Asp Thr Val  Asn Lys Thr Phe Asp  Trp Asn Arg 
    1340                 1345                 1350             


Glu Ile  Pro Ser Leu Leu Ile  Pro Pro Arg Ser Asn  Leu Phe Leu 
    1355                 1360                 1365             


Leu Glu  Thr Gly Gln Lys Ile  Thr Phe Glu Tyr Ile  Ala Asn Gly 
    1370                 1375                 1380             


Ala Asn  Ala Glu Val Lys Lys  Ala Tyr Ser Leu Arg  Arg Ala 
    1385                 1390                 1395         


<210> 240
<211> 1186
<212> PRT
<213> Gardnerella vaginalis


<220>
<223> Gardnerella vaginalis 1500E

<400> 240
Met Glu Gly Asn Ile Ser Tyr Ala Ile Gly Ile Asp Val Gly Leu Asn 
1               5                   10                  15      


Ser Val Gly Leu Ala Ala Ile Arg Leu Asp Asn Asn Gly Glu Pro Ile 
            20                  25                  30          


Arg Ile Leu Lys Ala Met Ser Val Ile His Asp Ala Gly Ile Asp Pro 
        35                  40                  45              


Asn Gly Ala Lys Glu Ser Asp Thr Arg Lys Ala Ile Ser Gly Val Ala 
    50                  55                  60                  


Arg Arg Val Arg Arg Leu Tyr Arg Gln Arg Arg Arg Arg Leu Gln Lys 
65                  70                  75                  80  


Leu Asp Phe Leu Leu His Ser Leu Gly Phe Pro Val Val Glu Asn Lys 
                85                  90                  95      


Asp Leu Asp Phe Ser Asp Ser Phe Ile Pro Trp Ile Phe Arg Ala Lys 
            100                 105                 110         


Leu Ala Asp Glu Tyr Ile Ala Asp Glu Lys Gln Arg Lys Gln Met Leu 
        115                 120                 125             


Ser Val Ala Ile Arg His Ile Ala Arg His Arg Gly Trp Arg Asn Pro 
    130                 135                 140                 


Tyr Gln Ser Ile Lys Ser Met Thr Gln Glu Thr Glu Tyr Ser Glu Phe 
145                 150                 155                 160 


Tyr Asn Glu Leu Leu Lys Asn Ile Glu Lys Phe Ala Pro Gly Val Gly 
                165                 170                 175     


Cys Glu Gly Ser Thr Pro Ala Gln Leu Val Arg Asp Tyr Leu Leu Leu 
            180                 185                 190         


Gln Gln Gly Lys Ala Ser Arg Arg Leu Arg Ile Thr Thr Asp Glu Lys 
        195                 200                 205             


Arg Lys Asn His Pro Asn Ser Leu Asn Pro Ile Leu Pro Arg Lys Leu 
    210                 215                 220                 


Met Gln Ser Asp Asn Met Leu Glu Ile Leu Asn Ile Phe Asn Val Gln 
225                 230                 235                 240 


His Ile Asp Asp Lys Tyr Val Arg Glu Gln Ile Ile Asn Ala Val Phe 
                245                 250                 255     


Tyr Ala Lys Ser Pro Arg Gly Ser Ala Glu Asn Arg Val Gly Lys Asp 
            260                 265                 270         


Ala Ile Thr Gly Lys Gly Lys Arg Ala Leu Lys Ala Ser Leu Ala Phe 
        275                 280                 285             


Gln Lys Tyr Arg Ile Ile Ser Thr Ile Ser Asn Leu Arg Ile Arg Glu 
    290                 295                 300                 


Asn Ser Lys Glu Arg Cys Leu Thr Ile Glu Glu Lys Gln Ser Val Tyr 
305                 310                 315                 320 


Lys Leu Leu Thr Thr Ser Thr Asp Glu Ser Ser Lys Glu Lys Ser Ala 
                325                 330                 335     


Glu Ala Pro Leu Tyr Thr Trp Ile Asp Val Ala Asp Cys Leu Gly Ile 
            340                 345                 350         


Glu Arg Tyr Lys Leu Arg Gly Val Gly Ser Gln Ile Gly Asp Gly Glu 
        355                 360                 365             


Ser Val Gly Asn Arg Pro Pro Met Leu Asn Ser Glu Leu Ala Ile Ile 
    370                 375                 380                 


Tyr Ala Asn Asn Lys Ser Leu Gly Lys Ser Leu Leu Thr Trp Trp Leu 
385                 390                 395                 400 


Asp Ala Asn Arg Thr Gln Glu Asp Lys Glu Ala Leu Ile Glu Ile Leu 
                405                 410                 415     


Ser Asn Thr Val Asp Ile Glu Ala Ile His Asp Asn Pro Glu Tyr Gln 
            420                 425                 430         


Asp Lys Tyr Gly Ser Ala Ile Ala Phe Ile Asp Ser Met Asp Glu Thr 
        435                 440                 445             


Glu Ile Ala Ala Leu Glu Asn Ile Ser Leu Pro Asp Gly Arg Ala Ala 
    450                 455                 460                 


Tyr Ser Leu Glu Thr Leu Asp Lys Leu Asn Lys Gln Met Leu Glu Thr 
465                 470                 475                 480 


Asp Asp Asp Leu Phe Glu Ala Arg Lys Lys Leu Phe Asn Leu Pro Asn 
                485                 490                 495     


Asn Trp Arg Pro Ser Glu Ala Pro Ile Ala Glu Pro Thr Gly Asn Pro 
            500                 505                 510         


Ser Val Asp Arg Val Leu Lys Ile Val His Arg Phe Leu Ile Ser Ala 
        515                 520                 525             


Lys Asn Arg Trp Gly Asn Pro Glu Arg Ile Asn Ile Glu His Val Arg 
    530                 535                 540                 


Ser Gly Phe Lys Ser Lys Lys Met Ala Asn Ser Tyr Lys Glu Leu Leu 
545                 550                 555                 560 


Asp Lys Arg Thr Lys Gly Lys Glu Asn Leu Lys Ala Met Met Arg Asn 
                565                 570                 575     


Ser Leu His Leu Gly Met Ser Asp Ser Ile Ser Asp Ala Asp Ile Arg 
            580                 585                 590         


Arg Tyr Glu Ala Val Gln Arg Gln Asn Gly Gln Cys Leu Tyr Cys Gly 
        595                 600                 605             


Ser Glu Ile Thr Tyr His Thr Cys Glu Leu Asp His Ile Val Pro Arg 
    610                 615                 620                 


Lys Gly Pro Gly Ser Thr Asn Thr Arg Glu Asn Leu Val Ala Thr Cys 
625                 630                 635                 640 


Ser Leu Cys Asn Ala Gln Lys Cys Asn Thr Pro Phe Ser Thr Trp Cys 
                645                 650                 655     


Glu Gln Ser Thr Tyr Cys Lys Asn His Asp Ile Ser Val Asp Ser Ala 
            660                 665                 670         


Ile Asn Arg Val Arg Ala Phe Ile Phe Pro Pro Asn Ser Tyr Asp Lys 
        675                 680                 685             


Arg Gly Ala Asn Gln Phe Lys Lys Glu Val Ile Ala Arg Leu Lys Gln 
    690                 695                 700                 


Lys Val Gly Asp Glu Ala Phe Asp Asn Arg Ser Ile Glu Ser Val Ala 
705                 710                 715                 720 


Trp Met Ala Asn Glu Leu His Arg Arg Ile Asp Trp Tyr Tyr Asn Ser 
                725                 730                 735     


Gln Asn Tyr Gln Thr Asn Asn Gly Ile Ser Asp Ile Thr Asn Lys Ala 
            740                 745                 750         


Gln Thr Asn Val Gly Val Tyr Ala Gly Ser Leu Thr Ala Ile Ala Arg 
        755                 760                 765             


Arg Met Ser Gly Ile Asp Gly Lys Leu Glu Phe Phe Asp Gly Arg Arg 
    770                 775                 780                 


Lys Thr Arg Phe Asp Arg Arg His His Ala Val Asp Ala Ser Val Ile 
785                 790                 795                 800 


Ala Met Met Thr Pro Gly Ile Ala Gln Ile Leu Ala Ile Lys Cys Asn 
                805                 810                 815     


Leu Arg Glu Thr Gln Leu Leu Gln Gly Asn Lys Val Val Pro Gly Gly 
            820                 825                 830         


Ile Asp Trp Lys Glu Tyr Pro Thr Ala Asn Asp Gln Gly Tyr Gln Gln 
        835                 840                 845             


Tyr Ala Asn Trp Ser Val Arg Met Asn Ala Leu Leu Lys Leu Leu Asn 
    850                 855                 860                 


Glu Glu Met Arg Ala Asp Arg Ile Ala Val Val Asn Ser Ile Arg Leu 
865                 870                 875                 880 


Arg Tyr Asn Asn Ser Ser Val His Gln Tyr Lys Val Asn Ala Leu Leu 
                885                 890                 895     


Lys Leu His Val Gly Asp Glu Ile Asp Ser Gly Thr Ile Arg Arg Ser 
            900                 905                 910         


Ser Thr Pro Ala Leu Tyr Cys Ala Leu Thr Arg Asn Pro Asp Tyr Asp 
        915                 920                 925             


Val Asn Asn Gly Leu Pro Glu Asn Pro Asn Arg Ala Ile Leu Leu His 
    930                 935                 940                 


Asp Lys Lys Leu Asn Ala Asp Asp Ser Ile Thr Phe Phe Lys Ala Gln 
945                 950                 955                 960 


Ala Val Gln Leu Phe Val Arg Glu Gly Ser Ala Glu Ile Gly Ser Ser 
                965                 970                 975     


Thr His His Leu Arg Ile Tyr Glu Tyr Phe Lys Lys Leu Lys Ser Gly 
            980                 985                 990         


Lys Ile Lys Lys Ser Tyr Gly Met  Ile Arg Val Phe Gln  Asn Asp Leu 
        995                 1000                 1005             


His Arg  His Ile His Glu Asp  Leu Phe Ser Cys Asp  Leu Pro Glu 
    1010                 1015                 1020             


Gln Ser  Ile Ser Met Arg Tyr  Ala Asp Thr Glu Val  Ala His Ala 
    1025                 1030                 1035             


Val Gln  Thr Gly Asn Ser Asn  Tyr Leu Gly Tyr Leu  Val Pro Gly 
    1040                 1045                 1050             


Asp Glu  Ile Ile Val Asp Phe  Ser His Val Lys Leu  Ser Gly Asn 
    1055                 1060                 1065             


Ile Gly  Thr Phe Val Glu Phe  Leu Asn Lys Ile Gly  Ala Asn Cys 
    1070                 1075                 1080             


Ala Ala  Tyr Asn His Trp Val  Val Val Gly Thr Asp  Thr Glu Lys 
    1085                 1090                 1095             


Val Leu  Ile Leu Lys Pro Ser  Met Ile Ser Ser Glu  Gly Ile Asp 
    1100                 1105                 1110             


Lys Leu  Tyr Ser Asn Cys Lys  Arg Asn Asn Phe Asp  Tyr Ser Ser 
    1115                 1120                 1125             


Tyr Glu  Lys Ser Ile Asn Glu  Ile Leu Val Gly Lys  Gly Trp Arg 
    1130                 1135                 1140             


Val Ser  Val Asn Val Leu Ala  Lys Tyr Asn Ala Glu  Thr Ile Arg 
    1145                 1150                 1155             


Arg Asn  Ala Leu Gly Glu Val  Arg Trp Thr Ser Arg  Ser His Leu 
    1160                 1165                 1170             


Pro Ile  Ser Trp Ser Trp Asn  Thr Gly Glu Asn Arg  Glu 
    1175                 1180                 1185     


<210> 241
<211> 1186
<212> PRT
<213> Gardnerella vaginalis


<220>
<223> Gardnerella vaginalis 284V

<400> 241
Met Glu Gly Asn Ile Ser Tyr Ala Ile Gly Ile Asp Val Gly Leu Asn 
1               5                   10                  15      


Ser Val Gly Leu Ala Ala Ile Arg Leu Asp Asp Tyr Gly Glu Pro Ile 
            20                  25                  30          


Arg Ile Leu Lys Ala Met Ser Val Ile His Asp Ala Gly Ile Asp Pro 
        35                  40                  45              


Asn Gly Ala Lys Glu Ser Asp Thr Arg Lys Ala Ile Ser Gly Val Ala 
    50                  55                  60                  


Arg Arg Val Arg Arg Leu Tyr Arg Gln Arg Arg Arg Arg Leu Gln Lys 
65                  70                  75                  80  


Leu Asp Phe Leu Leu Gln Ser Leu Gly Trp Pro Val Val Glu Asn Lys 
                85                  90                  95      


Asp Leu Asp Phe Ser Asp Ser Phe Ile Pro Trp Ile Phe Arg Ala Lys 
            100                 105                 110         


Leu Ala Asp Glu Tyr Ile Ala Asp Glu Glu Gln Arg Lys Gln Met Leu 
        115                 120                 125             


Ser Val Ala Ile Arg His Ile Ala Arg His Arg Gly Trp Arg Asn Pro 
    130                 135                 140                 


Tyr Gln Ser Ile Lys Ser Met Met Gln Glu Thr Glu Tyr Ser Glu Phe 
145                 150                 155                 160 


Tyr Asn Glu Leu Leu Lys Asn Ile Glu Lys Leu Ala Pro Gly Val Gly 
                165                 170                 175     


Cys Glu Gly Ser Thr Pro Ala Gln Leu Val Arg Asp Tyr Leu Leu Ser 
            180                 185                 190         


Gln Gln Gly Lys Ala Ser Arg Arg Leu Arg Ile Thr Thr Gly Gly Arg 
        195                 200                 205             


Arg Lys Asn His Pro His Ser Leu Asp Pro Val Leu Pro Arg Lys Leu 
    210                 215                 220                 


Met Gln Ser Asp Asn Met Leu Glu Ile Leu Asn Ile Phe Asn Val Gln 
225                 230                 235                 240 


His Ile Asp Asp Lys Tyr Val Arg Glu Gln Ile Ile Asn Ala Val Phe 
                245                 250                 255     


Tyr Ala Glu Ser Pro Arg Gly Ser Ala Glu Asn Arg Val Gly Lys Asp 
            260                 265                 270         


Ala Ile Thr Gly Lys Gly Lys Arg Ala Leu Lys Ala Ser Leu Ala Phe 
        275                 280                 285             


Gln Lys Tyr Arg Ile Ile Ser Thr Ile Ser Asn Leu Arg Ile Arg Glu 
    290                 295                 300                 


Asn Ser Lys Glu Arg Cys Leu Thr Ile Glu Glu Lys Gln Asn Val Tyr 
305                 310                 315                 320 


Lys Leu Leu Thr Thr Ser Ile Asp Lys Ser Ser Lys Arg Lys Ser Ala 
                325                 330                 335     


Glu Ala Pro Leu Tyr Thr Trp Ile Asp Val Ala Asp Cys Leu Gly Ile 
            340                 345                 350         


Glu Arg Tyr Lys Leu Arg Gly Val Gly Ser Gln Ile Gly Asp Gly Glu 
        355                 360                 365             


Ser Val Gly Asn Arg Pro Pro Met Leu Asn Ser Glu Leu Ala Ile Leu 
    370                 375                 380                 


Tyr Ala Asn Asn Lys Ser Leu Gly Gln Ser Leu Ile Thr Trp Trp Leu 
385                 390                 395                 400 


Ala Ser Asn Arg Thr Gln Glu Asp Lys Glu Ala Leu Ile Glu Ile Leu 
                405                 410                 415     


Ser Asn Thr Val Asp Ile Glu Ala Ile His Asp Asn Pro Glu Tyr Gln 
            420                 425                 430         


Asp Lys Tyr Gly Ser Ala Ile Ala Phe Ile Asp Ser Met Asn Glu Thr 
        435                 440                 445             


Glu Ile Ala Ala Leu Glu Asn Ile Ser Leu Pro Asp Gly Arg Ala Ala 
    450                 455                 460                 


Tyr Ser Leu Glu Thr Leu Asp Glu Leu Asn Lys Gln Met Leu Glu Thr 
465                 470                 475                 480 


Asp Asp Asp Leu Phe Glu Ala Arg Lys Lys Leu Phe Asn Leu Pro Asn 
                485                 490                 495     


Asn Trp Arg Pro Ala Glu Ala Pro Ile Ala Glu Pro Thr Gly Asn Pro 
            500                 505                 510         


Ser Val Asp Arg Val Leu Lys Ile Val His Arg Phe Leu Ile Ser Ala 
        515                 520                 525             


Lys Asn Arg Trp Gly Asn Pro Glu Arg Ile Asn Ile Glu His Val Arg 
    530                 535                 540                 


Ser Gly Phe Gln Ser Lys Lys Met Ala Asn Ser Tyr Lys Glu Leu Leu 
545                 550                 555                 560 


Asp Lys Arg Thr Glu Gly Lys Glu Asn Leu Lys Ala Met Met Arg Asn 
                565                 570                 575     


Ser Leu His Leu Gly Thr Ser Asp Ser Ile Ser Asp Ala Asp Ile Arg 
            580                 585                 590         


Arg Tyr Glu Ala Val Gln Arg Gln Asn Gly Gln Cys Leu Tyr Cys Gly 
        595                 600                 605             


Ser Glu Ile Thr Tyr His Thr Cys Glu Leu Asp His Ile Val Pro Arg 
    610                 615                 620                 


Lys Gly Pro Gly Ser Thr Asn Thr Arg Glu Asn Leu Val Ala Thr Cys 
625                 630                 635                 640 


Ser Ser Cys Asn Ala Gln Lys Cys Asn Thr Pro Phe Ala Thr Trp Cys 
                645                 650                 655     


Glu Gln Ser Thr Tyr Cys Lys Asn His Asp Ile Ser Ala Asp Ser Ala 
            660                 665                 670         


Ile Asn Arg Val Arg Ala Phe Ile Phe Pro Pro Asn Ser Tyr Asp Lys 
        675                 680                 685             


Arg Gly Ala Asn Gln Phe Lys Lys Glu Val Ile Ala Arg Leu Lys Gln 
    690                 695                 700                 


Lys Val Gly Asp Glu Ala Phe Asp Asn Arg Ser Ile Glu Ser Val Ala 
705                 710                 715                 720 


Trp Met Ala Asn Glu Leu His Arg Arg Ile Asp Trp Tyr Tyr Asn Ser 
                725                 730                 735     


Gln Asn Tyr Gln Thr Asn Asn Gly Ile Ser Asp Ile Ser Asn Lys Ala 
            740                 745                 750         


Gln Thr Asn Val Gly Val Tyr Ala Gly Ser Leu Thr Ala Ile Ala Arg 
        755                 760                 765             


Arg Met Ser Gly Ile Asp Gly Lys Leu Glu Phe Phe Asp Gly Arg Arg 
    770                 775                 780                 


Lys Thr Arg Phe Asp Arg Arg His His Ala Val Asp Ala Ser Val Ile 
785                 790                 795                 800 


Ala Met Met Thr Pro Gly Ile Ala Gln Ile Leu Ala Ile Lys Cys Asn 
                805                 810                 815     


Leu Arg Glu Thr Gln Leu Leu Gln Gly Asn Lys Val Val Pro Gly Gly 
            820                 825                 830         


Ile Asp Trp Lys Glu Tyr Pro Thr Ala Asn Asp Gln Gly Tyr Gln Gln 
        835                 840                 845             


Tyr Ala Asn Trp Ser Val Arg Met Asn Ala Leu Leu Lys Leu Leu Asn 
    850                 855                 860                 


Glu Glu Met Arg Ala Asp Arg Ile Ala Val Val Asn Ser Ile Arg Leu 
865                 870                 875                 880 


Arg Tyr Ser Asn Ser Ser Val His Gln Tyr Glu Val Asn Ala Leu Leu 
                885                 890                 895     


Lys Leu His Val Gly Asp Glu Ile Asp Ser Glu Thr Ile Arg Arg Ser 
            900                 905                 910         


Ser Thr Pro Ala Leu Tyr Cys Ala Leu Thr Arg Asn Pro Asp Tyr Asp 
        915                 920                 925             


Val Asn Asn Gly Phe Pro Glu Asn Pro Gly Arg Thr Ile Leu Leu His 
    930                 935                 940                 


Asn Lys Lys Leu Asn Ala Asp Asp Ser Ile Thr Phe Phe Lys Ala Gln 
945                 950                 955                 960 


Ala Val Gln Leu Phe Val Arg Glu Gly Ser Ala Lys Ile Gly Asn Ser 
                965                 970                 975     


Ile His His Leu Arg Ile Tyr Glu Tyr Phe Glu Lys Leu Lys Ser Gly 
            980                 985                 990         


Lys Ile Lys Lys Ser Tyr Gly Met  Ile Arg Val Phe Gln  Asn Asp Leu 
        995                 1000                 1005             


His Arg  His Ile His Glu Asp  Leu Phe Ser Cys Asp  Leu Pro Glu 
    1010                 1015                 1020             


Gln Ser  Ile Ser Met Arg Tyr  Ala Asp Thr Lys Val  Ala His Ala 
    1025                 1030                 1035             


Val Gln  Thr Gly Asn Ala Asn  Tyr Leu Gly Tyr Leu  Val Pro Gly 
    1040                 1045                 1050             


Asp Glu  Ile Ile Val Asp Phe  Ser His Ile Thr Leu  Ser Glu Asn 
    1055                 1060                 1065             


Ile Gly  Lys Phe Val Glu Phe  Leu Asn Lys Ile Gly  Ala Asp Cys 
    1070                 1075                 1080             


Thr Ala  Tyr Arg His Trp Val  Val Val Gly Thr Asp  Thr Glu Lys 
    1085                 1090                 1095             


Val Leu  Ile Leu Lys Pro Ser  Met Ile Ser Ser Glu  Gly Ile Asp 
    1100                 1105                 1110             


Lys Leu  Tyr Ser Asn Cys Glu  Arg Asn Asn Phe Asp  Tyr Ser Ser 
    1115                 1120                 1125             


Tyr Glu  Lys Ser Ile Asn Glu  Ile Leu Ala Gly Lys  Gly Trp Arg 
    1130                 1135                 1140             


Val Ser  Val Asn Val Leu Ala  Gln Tyr Lys Ala Ala  Thr Ile Arg 
    1145                 1150                 1155             


Arg Asn  Ala Leu Gly Glu Val  Arg Trp Ala Ser Arg  Ser His Leu 
    1160                 1165                 1170             


Pro Ile  Ser Trp Ser Trp Asp  Thr Gly Glu Asn Arg  Glu 
    1175                 1180                 1185     


<210> 242
<211> 1186
<212> PRT
<213> Gardnerella vaginalis


<220>
<223> Gardnerella vaginalis 5-1

<400> 242
Met Glu Gly Asn Ile Ser Tyr Ala Ile Gly Ile Asp Val Gly Leu Asn 
1               5                   10                  15      


Ser Val Gly Leu Ala Ala Ile Arg Leu Asp Asn Asn Gly Glu Pro Ile 
            20                  25                  30          


Arg Ile Leu Lys Ala Met Ser Val Ile His Asp Ala Gly Ile Asp Pro 
        35                  40                  45              


Asn Gly Ala Lys Glu Ser Asp Thr Arg Lys Ala Ile Ser Gly Val Ala 
    50                  55                  60                  


Arg Arg Val Arg Arg Leu Tyr Arg Gln Arg Arg Arg Arg Leu Gln Lys 
65                  70                  75                  80  


Leu Asp Phe Leu Leu His Ser Leu Gly Phe Pro Val Val Glu Asn Lys 
                85                  90                  95      


Asp Leu Asp Phe Ser Asp Ser Phe Thr Pro Trp Ile Phe Arg Ala Lys 
            100                 105                 110         


Leu Ala Asp Glu Tyr Ile Ala Asp Glu Lys Gln Arg Lys Gln Met Leu 
        115                 120                 125             


Ser Val Ala Ile Arg His Ile Ala Arg His Arg Gly Trp Arg Asn Pro 
    130                 135                 140                 


Tyr Gln Ser Ile Lys Ser Met Thr Gln Glu Thr Glu Tyr Ser Glu Phe 
145                 150                 155                 160 


Tyr Asn Glu Leu Leu Lys Asn Ile Glu Lys Phe Ala Pro Gly Val Ser 
                165                 170                 175     


Cys Glu Gly Ser Thr Pro Ala Gln Leu Val Arg Asp Tyr Leu Leu Ser 
            180                 185                 190         


Gln Gln Gly Lys Ala Ser Arg Arg Leu Arg Ile Thr Thr Asp Asp Arg 
        195                 200                 205             


Arg Lys Asn His Pro Asn Ser Leu Asp Pro Val Leu Pro Arg Lys Leu 
    210                 215                 220                 


Met Gln Ser Asp Asn Met Leu Glu Ile Leu Asn Ile Phe Asn Val Gln 
225                 230                 235                 240 


His Ile Asp Asn Lys Tyr Val Arg Glu Gln Ile Ile Asn Ala Val Phe 
                245                 250                 255     


Tyr Ala Lys Ser Pro Arg Gly Ser Ala Glu Asn Arg Val Gly Lys Asp 
            260                 265                 270         


Ala Ile Thr Gly Lys Gly Lys Arg Ala Leu Lys Ala Ser Leu Ala Phe 
        275                 280                 285             


Gln Lys Tyr Arg Ile Ile Ser Thr Ile Ser Asn Leu Arg Ile Arg Glu 
    290                 295                 300                 


Asn Ser Lys Glu Arg Cys Leu Thr Ile Glu Glu Lys Gln Ser Val Tyr 
305                 310                 315                 320 


Lys Leu Leu Thr Thr Ser Thr Asp Glu Tyr Ser Lys Glu Lys Ser Ala 
                325                 330                 335     


Glu Ala Pro Leu Tyr Thr Trp Ile Asp Val Ala Asp Cys Leu Gly Ile 
            340                 345                 350         


Glu Arg Tyr Lys Leu Arg Gly Val Gly Ser Gln Ile Glu Asp Gly Glu 
        355                 360                 365             


Ser Val Gly Asn Arg Pro Pro Met Leu Asn Ser Glu Leu Ala Ile Leu 
    370                 375                 380                 


Tyr Ala Asn Ala Lys Ser Leu Lys Gln Ser Leu Ile Thr Trp Trp Leu 
385                 390                 395                 400 


Ala Ala Asn Arg Thr Gln Glu Asp Lys Glu Ala Phe Ile Glu Ile Leu 
                405                 410                 415     


Ser Asn Thr Val Asp Ile Glu Ala Ile His Asp Asn Pro Glu Tyr Gln 
            420                 425                 430         


Asp Lys Tyr Gly Ser Val Ile Ala Phe Ile Asp Ser Met Asp Glu Thr 
        435                 440                 445             


Glu Ile Ala Ala Leu Glu Asn Ile Ser Leu Pro Asn Gly Arg Ala Ala 
    450                 455                 460                 


Tyr Ser Leu Glu Thr Leu Asp Lys Leu Asn Lys Gln Met Leu Glu Thr 
465                 470                 475                 480 


Asp Asp Asp Leu Phe Glu Ala Arg Lys Lys Leu Phe Asn Leu Pro Asn 
                485                 490                 495     


Asn Trp Arg Pro Ser Glu Ala Pro Ile Ala Glu Pro Thr Gly Asn Pro 
            500                 505                 510         


Ser Val Asp Arg Val Leu Lys Ile Val His Arg Phe Leu Ile Ser Ala 
        515                 520                 525             


Lys Asn Arg Trp Gly Asn Pro Glu Arg Ile Asn Ile Glu His Val Arg 
    530                 535                 540                 


Ser Gly Phe Gln Ser Lys Lys Met Ala Asn Ser Tyr Lys Lys Leu Leu 
545                 550                 555                 560 


Asp Lys Arg Thr Glu Gly Lys Glu Asn Leu Lys Ala Met Met Arg Asn 
                565                 570                 575     


Ser Leu His Leu Gly Thr Ser Asp Ser Ile Ser Asp Ala Asp Ile Arg 
            580                 585                 590         


Arg Tyr Glu Ala Val Gln Arg Gln Asn Gly Gln Cys Leu Tyr Cys Gly 
        595                 600                 605             


Ser Glu Ile Thr Tyr His Thr Cys Glu Leu Asp His Ile Val Pro Arg 
    610                 615                 620                 


Lys Gly Pro Gly Ser Thr Asn Thr Arg Glu Asn Leu Val Ala Thr Cys 
625                 630                 635                 640 


Ser Ser Cys Asn Ala Gln Lys Cys Asn Thr Pro Phe Ala Thr Trp Cys 
                645                 650                 655     


Glu Glu Ser Thr Tyr Cys Lys Asn His Asp Ile Ser Val Asp Ser Ala 
            660                 665                 670         


Ile Asn Arg Val Arg Ala Phe Ile Phe Pro Pro Asn Ser Tyr Asp Lys 
        675                 680                 685             


Arg Gly Ala Ser Gln Phe Lys Lys Glu Val Ile Ala Arg Leu Lys Gln 
    690                 695                 700                 


Lys Val Gly Asp Glu Ala Phe Asp Asn Arg Ser Ile Glu Ser Val Ala 
705                 710                 715                 720 


Trp Met Ala Asn Glu Leu His Arg Arg Ile Asp Trp Tyr Tyr Asn Ser 
                725                 730                 735     


Gln Asn Tyr Gln Thr Asn Asn Gly Ile Ser Asp Ile Thr Asn Lys Ala 
            740                 745                 750         


Gln Thr Asn Val Gly Val Tyr Ala Gly Ser Leu Thr Ala Ile Ala Arg 
        755                 760                 765             


Arg Met Ser Gly Ile Asp Gly Lys Leu Glu Phe Phe Asp Gly Arg Arg 
    770                 775                 780                 


Lys Thr Arg Phe Asp Arg Arg His His Ala Val Asp Ala Ser Val Ile 
785                 790                 795                 800 


Ala Met Met Thr Pro Gly Ile Ala Gln Ile Leu Ala Ile Lys Cys Asn 
                805                 810                 815     


Leu Arg Glu Thr Gln Leu Leu Gln Gly Asn Lys Val Val Pro Gly Gly 
            820                 825                 830         


Ile Asp Trp Lys Glu Tyr Pro Thr Ala Asn Asp Gln Gly Tyr Gln Gln 
        835                 840                 845             


Tyr Ala Asn Trp Ser Val Arg Met Asn Ala Leu Leu Glu Leu Leu Asn 
    850                 855                 860                 


Glu Glu Met Arg Ala Asp Arg Ile Ala Val Val Asn Ser Ile Arg Leu 
865                 870                 875                 880 


Arg Tyr Ser Asn Ser Ser Val His Lys Asp Asp Val His Ala Leu Leu 
                885                 890                 895     


Lys Leu His Val Gly Asp Glu Ile Asp Ser Glu Thr Ile Arg Arg Ala 
            900                 905                 910         


Ser Thr Pro Ala Leu Tyr Cys Ala Leu Thr Arg Asn Pro Asp Tyr Asp 
        915                 920                 925             


Val Asn Asn Gly Leu Pro Glu Asn Thr Asp Arg Thr Ile Leu Leu His 
    930                 935                 940                 


Asp Lys Lys Leu Asn Ala Asp Asp Ser Ile Thr Phe Phe Lys Ser Lys 
945                 950                 955                 960 


Ala Ala Gln Leu Phe Val Arg Glu Gly Ser Val Glu Ile Gly Asn Ser 
                965                 970                 975     


Ile His His Leu Arg Ile Tyr Glu Tyr Phe Glu Lys Leu Lys Ser Gly 
            980                 985                 990         


Lys Val Lys Lys Ser Tyr Gly Met  Ile Arg Val Phe Gln  Asp Asp Leu 
        995                 1000                 1005             


His Arg  Tyr Ile His Glu Asp  Leu Phe Ser Cys Asp  Leu Pro Glu 
    1010                 1015                 1020             


Gln Ser  Ile Ser Met Arg Tyr  Ala Asp Thr Lys Val  Ala His Ala 
    1025                 1030                 1035             


Val Gln  Thr Gly Asn Ala Asn  Tyr Leu Gly Tyr Leu  Val Pro Gly 
    1040                 1045                 1050             


Asp Glu  Ile Ile Val Asp Phe  Ser His Val Lys Leu  Ser Gly Tyr 
    1055                 1060                 1065             


Ile Gly  Glu Phe Val Glu Phe  Leu Asn Lys Ile Gly  Ala Asn Cys 
    1070                 1075                 1080             


Ala Ala  Tyr Lys His Trp Val  Val Ala Gly Thr Asp  Asp Lys Thr 
    1085                 1090                 1095             


Thr Leu  Ile Leu Lys Pro Ser  Met Ile Ser Ser Glu  Gly Ile Asp 
    1100                 1105                 1110             


Lys Leu  Tyr Ser Asn Cys Glu  Arg Asn Asn Phe Asp  Tyr Ala Ser 
    1115                 1120                 1125             


Tyr Glu  Lys Ser Ile Asp Lys  Ile Leu Val Asp Lys  Gly Trp Arg 
    1130                 1135                 1140             


Val Ser  Val Asn Val Leu Asp  Gln Tyr Lys Ala Ala  Thr Ile Arg 
    1145                 1150                 1155             


Arg Asn  Ala Leu Gly Glu Pro  Arg Trp Ala Ser Arg  Ser His Leu 
    1160                 1165                 1170             


Pro Ile  Ser Trp Ser Trp Asp  Thr Gly Glu Asn Arg  Glu 
    1175                 1180                 1185     


<210> 243
<211> 1392
<212> PRT
<213> Gemella haemolysans


<220>
<223> Gemella haemolysans ATCC 10379

<400> 243
Met Ala Asn Lys Thr Trp Tyr Leu Gly Leu Asp Ile Gly Ser Ala Ser 
1               5                   10                  15      


Val Gly Trp Ala Ala Thr Asp Thr Gly Tyr Lys Ile Ile Arg Lys Asn 
            20                  25                  30          


Lys Lys Arg Leu Trp Gly Val Arg Leu Phe Glu Glu Ala Lys Thr Ala 
        35                  40                  45              


Glu Asp Arg Arg Gly Tyr Arg Ser Ser Arg Arg Arg Leu Ala Arg Arg 
    50                  55                  60                  


Lys Trp Arg Leu Asn Leu Leu Glu Glu Leu Phe Thr Ser Glu Val Lys 
65                  70                  75                  80  


Lys Val Asp Glu Asn Phe Phe Leu Arg Leu Lys Glu Ser Gln Tyr His 
                85                  90                  95      


Tyr Glu Asp Lys Thr His Lys Val Pro Tyr Ala Ile Phe Asn Asp Lys 
            100                 105                 110         


Asp Tyr Thr Asp Lys Asp Tyr Tyr Lys Asp Tyr Pro Thr Ile Tyr His 
        115                 120                 125             


Leu Arg Ser Lys Leu Met Thr Glu Glu Asn Pro Asp Ile Arg Lys Val 
    130                 135                 140                 


Phe Leu Ala Ile His His Ile Ile Lys Asn Arg Gly His Phe Leu Leu 
145                 150                 155                 160 


Gln Gly Gln Ser Phe Lys Asp Gly Asn Leu Asn Asn Leu Ile Lys Glu 
                165                 170                 175     


Leu Leu Glu Leu Asp Ile Leu His Val Gly Phe Glu Val Thr Glu Glu 
            180                 185                 190         


Val Val Asp Lys Ile Ala Asp Ile Ser Leu Glu Lys Lys Thr Ser Lys 
        195                 200                 205             


Asp Lys Leu Asn Asp Ile Lys Glu Leu Tyr Pro Lys Glu Lys Gln Leu 
    210                 215                 220                 


Leu Glu Val Phe Arg Leu Ile Phe Gly Gly Lys Thr Ser Leu Asp Lys 
225                 230                 235                 240 


Leu Phe Ala Ile Asp Glu Tyr Lys Glu Leu Asp Ala Ala Ile Lys Ser 
                245                 250                 255     


Val Ser Phe Lys Glu Lys Ile Tyr Glu Glu Val Arg His Asp Tyr Glu 
            260                 265                 270         


Gln Val Leu Ser Asn Tyr Ile Glu Leu Leu Asp Leu Ala Lys Leu Val 
        275                 280                 285             


Tyr Asp Ser Ile Ile Leu Ser Asp Ile Lys Lys Glu Gly Lys Thr Leu 
    290                 295                 300                 


Ser Glu Ser Lys Val Glu Leu Phe Glu Lys His Arg Asp Asp Leu Leu 
305                 310                 315                 320 


Lys Leu Lys Asn Leu Val Lys Asn Asp Ser Lys Leu Ser Glu Asp Lys 
                325                 330                 335     


Lys Val Glu Leu Tyr Ala Leu Ile Phe Lys Glu Asp Lys Asp Lys Gly 
            340                 345                 350         


Thr Asn Tyr Val Asn Tyr Ile Arg Lys Ser Glu Glu Gly Lys Gly Cys 
        355                 360                 365             


Asn Tyr Glu Asp Phe Lys Lys Phe Leu Val Lys Glu Leu Ala Lys Leu 
    370                 375                 380                 


Glu Glu Ser Ser Val Lys Thr Glu Ile Ile Lys Asp Leu Glu Leu Glu 
385                 390                 395                 400 


Gln Phe Leu Pro Leu Gln Arg Thr Lys Asp Asn Ser Val Val Pro Tyr 
                405                 410                 415     


Gln Ile His Lys Glu Glu Leu Val Lys Ile Leu Asp Asn Ala Ala Arg 
            420                 425                 430         


Tyr His Ser Phe Leu Asn Glu Lys Asp Glu Ser Gly Tyr Asn Val Arg 
        435                 440                 445             


Glu Lys Val Ile Gln Leu Leu Glu Phe Arg Ile Pro Tyr Tyr Val Gly 
    450                 455                 460                 


Pro Leu Asn Ser Ser Lys Lys Ala Lys Glu Gly Gly Phe Ala Trp Ser 
465                 470                 475                 480 


Val Arg Asn Thr Gly Tyr Glu Asn Thr Pro Val Thr Pro Trp Asn Tyr 
                485                 490                 495     


Ser Lys Val Ile Asp Glu Ser Ala Ser Ala Glu Lys Phe Ile Thr Asn 
            500                 505                 510         


Leu Thr Asn Lys Cys Thr Tyr Leu Lys Gly Glu Asp Val Leu Pro Lys 
        515                 520                 525             


Ser Ser Leu Leu Tyr Ser Glu Phe Ala Leu Leu Asn Glu Leu Asn Ala 
    530                 535                 540                 


Leu Lys Tyr Asp Gly Asn Arg Ile Ser Leu Glu Ala Arg Asn Thr Ile 
545                 550                 555                 560 


Ile Glu Lys Leu Phe Lys Gln Gln Gly Lys Lys Val Thr Lys Thr Ser 
                565                 570                 575     


Ile Lys Asn Leu Leu Lys Ala Glu Gly Tyr Ile Asp Gly Lys Gly Glu 
            580                 585                 590         


Ile Thr Gly Ile Asp Ile Thr Val Lys Asn Asp Leu Lys Ser Tyr Arg 
        595                 600                 605             


Asp Phe Lys Lys Ile Leu Gly Asn Lys Phe Asn Ser Glu His Val Glu 
    610                 615                 620                 


Asn Ile Ile Leu Trp Ile Thr Leu Tyr Gly Glu Ser Arg Lys Leu Ile 
625                 630                 635                 640 


Lys Ala Lys Ile Glu Ser Val Tyr Gly Glu Val Tyr Ser Lys Asp Glu 
                645                 650                 655     


Ile Thr Lys Met Ser Arg Leu Val Tyr Lys Asp Trp Gly Arg Phe Ser 
            660                 665                 670         


Arg Lys Leu Leu Thr Glu Leu Val Ser Lys Lys Leu Tyr Asn Glu Glu 
        675                 680                 685             


Thr Gly Glu Cys Leu Asn Ile Ile Gly Ala Met Arg Gln Asn Asn Ile 
    690                 695                 700                 


Leu Phe Met Glu Leu Leu Ala Asp Arg Phe Asp Tyr Ser Lys Gln Ile 
705                 710                 715                 720 


Val Glu Phe Asn Lys Glu Leu Gln Glu Asp Val Thr Glu Ile Ala Pro 
                725                 730                 735     


Glu Ile Leu Asp Asp Leu Tyr Val Ser Pro Ala Val Lys Arg Ser Ile 
            740                 745                 750         


Trp Gln Thr Val Arg Ile Val Glu Glu Leu Lys Lys Ile Ile Gly Cys 
        755                 760                 765             


Ala Pro Ala Lys Ile Phe Val Glu Thr Thr Arg Ser Asn Gln Glu Lys 
    770                 775                 780                 


Lys Lys Pro Thr Asp Ser Arg Lys Lys Gln Leu Glu Leu Ala Tyr Lys 
785                 790                 795                 800 


Ala Val Lys Lys Asp Val Lys Glu Leu Glu Lys Glu Ile Gly Thr Ile 
                805                 810                 815     


Asn Phe Asp Val Leu Asn Asp Arg Leu Ser Ser Val Glu Pro Ser Lys 
            820                 825                 830         


Leu Lys Ala Lys Lys Leu Tyr Leu Tyr Tyr Thr Gln Leu Gly Arg Cys 
        835                 840                 845             


Met Tyr Ser Glu Glu Pro Ile Asn Ile Ser Glu Leu Phe Asp Asn Asn 
    850                 855                 860                 


Lys Tyr Asp Ile Asp His Ile Tyr Pro Gln Ser Lys Ile Lys Asp Asp 
865                 870                 875                 880 


Ser Phe Thr Asn Thr Val Leu Val Lys Arg Glu Ser Asn Ala Ala Lys 
                885                 890                 895     


Thr Asp Arg Tyr Pro Leu Gly Ser Asp Ile Gln Thr Pro Ser Asn Arg 
            900                 905                 910         


Arg Phe Trp Lys Phe Leu Lys Glu Lys Gly Leu Ile Ser Asp Glu Lys 
        915                 920                 925             


Tyr Asn Arg Leu Val Arg Thr Glu Glu Phe Ser Asp Glu Glu Leu Ser 
    930                 935                 940                 


Gly Phe Ile Ala Arg Gln Leu Val Glu Thr Ser Gln Ser Val Lys Ala 
945                 950                 955                 960 


Val Ala Ser Ile Leu Gly Glu Leu Asn Pro Glu Thr Ser Ile Cys Tyr 
                965                 970                 975     


Ser Lys Ala Glu Asn Val Ser Ser Phe Arg Gln Asn Phe Gly Lys Ile 
            980                 985                 990         


Lys Lys Gly Asp Arg Asp Ser Lys  Asn Asn Asp Gln Leu  Ile Lys Val 
        995                 1000                 1005             


Arg Glu  Ile Asn Asp Tyr His  His Ala Lys Asp Ala  Tyr Leu Asn 
    1010                 1015                 1020             


Val Val  Val Gly Asn Val Tyr  Asp Thr Lys Phe Thr  Arg Asn Val 
    1025                 1030                 1035             


Phe Asn  Phe Ile Lys Asp Lys  Lys Asp Gly Arg Lys  Tyr Ser Leu 
    1040                 1045                 1050             


Asn Lys  Val Phe Tyr Glu Asn  Val Ser Asp Ser Lys  Thr Val Ala 
    1055                 1060                 1065             


Trp Glu  Met Asp Lys Thr Ile  His Gln Val Glu Lys  Val Met Asn 
    1070                 1075                 1080             


Asn Asn  Asn Ile Met Val Thr  Arg Arg Thr Ser Glu  Gln Lys Gly 
    1085                 1090                 1095             


Gly Leu  Phe Asp Ala Thr Val  Tyr Lys Ala Lys Val  Ala Ala Lys 
    1100                 1105                 1110             


Ala Lys  Asp Gly Val Tyr Tyr  Pro Leu Lys Thr Ser  Asn Ser Val 
    1115                 1120                 1125             


Val Lys  Asp Val Ala Lys Tyr  Gly Gly Tyr Thr Ser  Ile Gly Ile 
    1130                 1135                 1140             


Ala Tyr  Tyr Ser Ile Phe Glu  Tyr Thr Ile Val Asn  Lys Lys Gly 
    1145                 1150                 1155             


Glu Glu  Lys Ile Thr Arg Ile  Ile Pro Ile Pro Ile  Tyr Ile Ser 
    1160                 1165                 1170             


Gln Asn  Ile Lys Asp Ser Thr  Ala Leu Ile Glu Phe  Gly Lys Ser 
    1175                 1180                 1185             


Gln Ile  Phe Cys Arg Ala Tyr  Glu Lys Ile Lys Asp  Phe Lys Leu 
    1190                 1195                 1200             


Leu Tyr  Arg Lys Leu Cys Ile  Gly Ser Lys Ile Asn  Ile Asn Asn 
    1205                 1210                 1215             


Tyr Gln  Tyr Tyr Ile Gly Gly  Lys Ser Asp Glu Arg  Phe Tyr Tyr 
    1220                 1225                 1230             


Asp Ser  Ala Ile Gln Val Thr  Leu Asp Lys Lys Ser  Glu Lys Tyr 
    1235                 1240                 1245             


Leu Lys  Ile Leu Ser Lys Tyr  Gln Asn Trp Lys Lys  Glu Asn Lys 
    1250                 1255                 1260             


Asp Gly  Glu Leu Trp Glu Asn  Ile Thr Lys Glu Asn  Asn Ile Glu 
    1265                 1270                 1275             


Leu Tyr  Asn Lys Leu Val Glu  Lys Met Asn Ser Glu  Ile Phe Thr 
    1280                 1285                 1290             


Lys Lys  Lys Ser Asn Lys Tyr  Asn Glu Leu Asn Ser  Glu Glu Ile 
    1295                 1300                 1305             


Arg Asn  Asn Phe Ile Lys Ile  Ser Val Glu Glu Gln  Ala Lys Val 
    1310                 1315                 1320             


Leu Leu  Glu Ile Leu Asn Leu  Leu Thr Asn Lys Lys  Ser Ile Phe 
    1325                 1330                 1335             


Asp Leu  Lys Ser Ile Asp Ile  Lys Ala Ala Arg Gly  Lys Ile Ser 
    1340                 1345                 1350             


Phe Asn  Leu Thr Ser Leu Ile  Gln Phe Ser Ile Ile  Glu Gln Ser 
    1355                 1360                 1365             


Ile Thr  Gly Phe Tyr Glu Lys  Glu Ile Thr Ile Ile  Gly Asp Lys 
    1370                 1375                 1380             


Gly Asn  Asp Met Glu Asn Asn  Asn Ser 
    1385                 1390         


<210> 244
<211> 1385
<212> PRT
<213> Gemella morbillorum


<220>
<223> Gemella morbillorum M424

<400> 244
Met Lys Asn Lys Thr Trp Tyr Leu Gly Leu Gly Val Gly Pro Thr Ser 
1               5                   10                  15      


Ile Gly Trp Ala Ala Thr Asp Ser Asn Tyr Lys Leu Leu Arg Lys Asn 
            20                  25                  30          


Lys Lys Arg Leu Trp Gly Val Arg Leu Phe Glu Glu Ala Lys Thr Ala 
        35                  40                  45              


Val Asp Arg Arg Thr Phe Arg Ala Glu Arg Arg Arg Leu Ala Arg Arg 
    50                  55                  60                  


Lys Trp Arg Ile Ser Leu Leu Glu Glu Leu Phe Ala Lys Glu Val Ser 
65                  70                  75                  80  


Lys Asn Asp Pro Asn Phe Phe Leu Arg Leu Lys Glu Ser Lys Tyr His 
                85                  90                  95      


Phe Glu Asp Lys Ser Leu Met Asn Glu Tyr Ile Leu Phe Asn Asp Lys 
            100                 105                 110         


Asp Tyr Thr Asp Lys Asp Tyr Tyr Lys Glu Tyr Pro Thr Ile Tyr His 
        115                 120                 125             


Leu Arg Leu Ser Leu Thr Thr Glu Glu Asn Pro Asp Ile Arg Lys Val 
    130                 135                 140                 


Tyr Leu Ala Val His Ser Met Leu Lys Asn Arg Gly His Phe Leu Leu 
145                 150                 155                 160 


Gln Gly Gln Ser Phe Asn Asp Ser Asn Ile Asp Ser Val Ile Lys Glu 
                165                 170                 175     


Leu Leu Glu Leu Glu Thr Val Lys Ile Asn Phe Glu Val Thr Asp Glu 
            180                 185                 190         


Val Ile His Ser Leu Lys Lys Ile Ala Leu Glu Lys Lys Asn Leu Ser 
        195                 200                 205             


Asp Lys Asn Asn Asp Val Lys Lys Leu Tyr Pro Lys Glu Lys Gln Leu 
    210                 215                 220                 


Gln Glu Ile Phe Lys Leu Val Phe Gly Gly Lys Thr Ser Leu Asp Lys 
225                 230                 235                 240 


Leu Tyr Asp Ile Glu Glu Tyr Lys Glu Leu Asp Asn Ser Val Lys Ser 
                245                 250                 255     


Ile Ser Phe Lys Glu Lys Val Tyr Glu Glu Val Arg Pro Asp Tyr Glu 
            260                 265                 270         


Gln Ile Leu Ser Asn Tyr Ile Glu Leu Leu Asp Leu Ala Lys Leu Val 
        275                 280                 285             


Tyr Asp Ser Ile Val Leu Ala Asp Ile Lys Lys Glu Gly Lys Thr Ile 
    290                 295                 300                 


Ser Glu Ser Lys Val Glu Leu Tyr Asn Lys His Lys Asp Asp Leu Ala 
305                 310                 315                 320 


Asn Leu Lys Lys Leu Val Lys Ile Asp Ser Lys Leu Ser Glu Asp Lys 
                325                 330                 335     


Lys Lys Glu Val Tyr Phe Thr Ile Phe Lys Glu Asp Lys Glu Lys Gly 
            340                 345                 350         


Thr Asn Tyr Val Asn Tyr Thr His Arg Ser Gln Glu Gly Lys Ser Cys 
        355                 360                 365             


Ser Tyr Glu Asp Phe Lys Lys Phe Leu Lys Lys Glu Leu Glu Lys Leu 
    370                 375                 380                 


Glu Asp Ser Pro Thr Lys Thr Thr Ile Leu Glu Glu Leu Asp Leu Glu 
385                 390                 395                 400 


Thr Phe Leu Pro Leu Gln Arg Thr Lys Asp Asn Ser Val Val Pro Tyr 
                405                 410                 415     


Gln Ile His Lys Glu Glu Leu Val Lys Ile Leu Asp Asn Ala Ala Lys 
            420                 425                 430         


Tyr His Ser Phe Leu Ala Glu Lys Asp Asp Ser Gly Tyr Ser Thr Arg 
        435                 440                 445             


Glu Lys Val Val Gln Leu Phe Glu Phe Arg Ile Pro Tyr Tyr Ile Gly 
    450                 455                 460                 


Pro Leu Asn Ala His His Asn Thr Glu Asn Gly Gly Tyr Ser Trp Ala 
465                 470                 475                 480 


Ile Arg Lys Lys Gly Met Glu Ser Val Pro Val Thr Pro Trp Asn Phe 
                485                 490                 495     


Lys Asp Val Ile Asp Glu Ser Ala Ser Ala Glu Ala Phe Val Asn Asn 
            500                 505                 510         


Leu Lys Asn Lys Cys Ala Tyr Leu Ser Gly Glu Asp Val Leu Pro Lys 
        515                 520                 525             


Asn Ser Leu Leu Tyr Ser Glu Tyr Ala Leu Leu Asn Glu Leu Asn Ala 
    530                 535                 540                 


Leu Arg Tyr Glu Gly Asn Arg Ile Ser Val Glu Ala Arg Asp Val Ile 
545                 550                 555                 560 


Val Thr Lys Leu Phe Lys Glu Gln Gly Lys Lys Val Thr Lys Lys Thr 
                565                 570                 575     


Ile Lys Glu Leu Leu Lys Thr Glu Gly Phe Ile Asp Gly Lys Gly Glu 
            580                 585                 590         


Ile Val Gly Ile Asp Asn Ile Val Lys Asn Asp Leu Lys Ser Tyr Arg 
        595                 600                 605             


Asp Phe Lys Lys Ile Leu Ala Asp Lys Phe Asp Lys Glu Arg Val Glu 
    610                 615                 620                 


Asn Ile Ile Leu Trp Ile Thr Leu Tyr Gly Glu Ser Arg Lys Leu Ile 
625                 630                 635                 640 


Lys Glu Lys Ile Thr Lys Val Tyr Gly Asp Phe Tyr Thr Val Asp Glu 
                645                 650                 655     


Ile Glu Lys Met Ser Arg Leu Thr Tyr Lys Asp Trp Gly Ile Leu Ser 
            660                 665                 670         


Arg Lys Leu Leu Thr Glu Leu Val Ser Glu Lys Leu Tyr Asn Glu Glu 
        675                 680                 685             


Thr Gly Glu Cys Leu Asn Ile Ile Gly Ala Met Arg Gln Gly Thr Ile 
    690                 695                 700                 


Leu Phe Met Glu Leu Leu Ala Asp Lys Phe Asp Tyr Met Ser Gln Ile 
705                 710                 715                 720 


Lys Asn His Asn Lys Glu Asn Lys Asp Asp Ile Thr Glu Ile Thr Pro 
                725                 730                 735     


Asp Ile Leu Glu Asn Leu His Ala Ser Pro Ala Val Lys Arg Ser Ile 
            740                 745                 750         


Trp Gln Thr Val Arg Ile Val Glu Glu Leu Lys Thr Ile Ile Gly Cys 
        755                 760                 765             


Val Pro Thr Lys Ile Phe Ile Glu Thr Thr Lys Arg Asn Asn Ala Pro 
    770                 775                 780                 


Tyr Lys Val Pro Thr Leu Asn Arg Asn Asp Leu Val Thr Lys Tyr Lys 
785                 790                 795                 800 


Thr Ile Arg Glu His Glu Ile Phe Glu Leu Glu Lys Glu Leu Lys Asn 
                805                 810                 815     


Thr Leu Asp Phe Thr Leu Asn Lys Asn Arg Leu Ile Asn Glu Glu Pro 
            820                 825                 830         


Ser Lys Leu Lys Ala Thr Lys Leu Tyr Leu Tyr Tyr Thr Gln Leu Gly 
        835                 840                 845             


Arg Cys Met Tyr Thr Gly Lys Lys Ile Asp Leu Gly Glu Leu Phe Asp 
    850                 855                 860                 


Asn Asn Asn Lys Tyr Asp Ile Asp His Ile Tyr Pro Gln Ser Lys Val 
865                 870                 875                 880 


Lys Asp Gly Ser Phe Asn Asn Ile Val Leu Val Thr Lys Ala Ser Asn 
                885                 890                 895     


Asp Met Lys Ala Asp Val Phe Pro Leu Lys Ser Lys Phe Gln Thr Lys 
            900                 905                 910         


Glu Asn Lys Ile Phe Trp Arg Phe Leu Lys Glu Lys Lys Leu Ile Thr 
        915                 920                 925             


Glu Glu Lys Tyr Asn Arg Leu Val Arg Thr Glu Glu Phe Ser Asn Gly 
    930                 935                 940                 


Glu Leu Thr Gly Phe Ile Thr Arg Gln Leu Val Glu Thr Ser Gln Ala 
945                 950                 955                 960 


Ile Lys Val Ile Ser Asn Val Leu Arg Glu Leu Asn Pro Glu Thr Thr 
                965                 970                 975     


Ile Cys Tyr Ser Lys Ala Glu Asn Val Ser Ser Phe Arg Gln Ser Phe 
            980                 985                 990         


Gly Lys Ile Lys Glu Ala Asn Arg  Lys Ala Glu Asn Asn  Glu Lys Leu 
        995                 1000                 1005             


Ile Arg  Val Gln Glu Ile Asn  Asp Tyr Tyr Asn Ala  Lys Asp Ala 
    1010                 1015                 1020             


Tyr Leu  Ser Ile Val Val Gly  Asn Val Tyr Asp Val  Lys Phe Thr 
    1025                 1030                 1035             


Arg Asn  Val His Asn Phe Ile  Lys Asn Asn Lys Asp  Ala Arg Arg 
    1040                 1045                 1050             


Tyr Ser  Leu Asn Gly Leu Phe  Tyr Thr Asp Val Lys  Asn Ala Asn 
    1055                 1060                 1065             


Thr Ile  Ala Trp Glu Met Asp  Lys Thr Val His Val  Val Glu Lys 
    1070                 1075                 1080             


Thr Met  Asn Asn Asn Asn Ile  Leu Ile Thr Arg Arg  Thr Ser Glu 
    1085                 1090                 1095             


Gln Lys  Gly Ala Leu Tyr Asp  Ala Thr Leu Tyr Lys  Ala Lys Val 
    1100                 1105                 1110             


Ala Glu  Lys Ala Lys Glu Gly  Thr Tyr Tyr Pro Leu  Lys Thr Thr 
    1115                 1120                 1125             


Asp Ser  Lys Ile Lys Asp Val  Gly Lys Tyr Gly Gly  Phe Thr Lys 
    1130                 1135                 1140             


Ile Lys  Ile Ala Tyr Tyr Ser  Ile Phe Glu Tyr Thr  Leu Asp Gly 
    1145                 1150                 1155             


Lys Lys  Gly Lys Gln Lys Ile  Thr Arg Ile Val Pro  Ile Pro Ile 
    1160                 1165                 1170             


Tyr Ile  Ser Gln Asn Ile Lys  Asp Asp Lys Ala Leu  Leu Glu Tyr 
    1175                 1180                 1185             


Ala Gln  Thr Arg Leu Pro Gly  Lys Asp Leu Lys Ile  Lys Tyr Arg 
    1190                 1195                 1200             


Lys Leu  Cys Ile Gly Ser Leu  Val Lys Ile Asn Asn  Phe Asn Tyr 
    1205                 1210                 1215             


Tyr Ile  Gly Gly Lys Thr Asn  Asn Asn Phe Thr Phe  Asp Ser Ala 
    1220                 1225                 1230             


Val Gln  Val Ile Leu Asp Lys  Asp Ser Glu Ser Tyr  Ile Lys Glu 
    1235                 1240                 1245             


Leu Ala  Lys Tyr Leu Asn Trp  Lys Lys Glu Asn Lys  Asp Gly Lys 
    1250                 1255                 1260             


Leu Trp  Glu Ser Ile Thr Glu  Asp Lys Asn Ile Gln  Leu Tyr Asp 
    1265                 1270                 1275             


Ser Leu  Val Lys Lys Met Asn  Thr Gly Ile Phe Ile  Arg Lys Thr 
    1280                 1285                 1290             


Pro Asn  Lys Tyr Thr Glu Leu  Leu Thr Leu Glu Val  Lys Asn Lys 
    1295                 1300                 1305             


Phe Ile  Asn Ile Asp Ile Asp  Glu Gln Val Lys Leu  Leu Leu Glu 
    1310                 1315                 1320             


Ile Leu  Asn Leu Leu Thr Asn  Lys Lys Phe Thr Ser  Lys Leu Asn 
    1325                 1330                 1335             


Glu Ile  Gly Ile Thr Ala Ser  Arg Gly Val Cys Ser  Phe Asn Leu 
    1340                 1345                 1350             


Ser Asn  Gln Ser Gln Phe Ser  Ile Ile Glu Gln Ser  Val Thr Gly 
    1355                 1360                 1365             


Val Tyr  Glu Lys Glu Lys Leu  Ile Ile Glu Lys Lys  Lys Glu Gly 
    1370                 1375                 1380             


Ile Leu  
    1385 


<210> 245
<211> 1003
<212> PRT
<213> Gluconacetobacter diazotrophicus

<400> 245
Met Ile Asp Glu Ser Leu Thr Phe Gly Ile Asp Leu Gly Ile Gly Ser 
1               5                   10                  15      


Cys Gly Trp Ala Val Leu Arg Arg Pro Ser Ala Phe Gly Arg Lys Gly 
            20                  25                  30          


Val Ile Glu Gly Met Gly Ser Trp Cys Phe Asp Val Pro Glu Thr Ser 
        35                  40                  45              


Lys Glu Arg Thr Pro Thr Asn Gln Ile Arg Arg Ser Asn Arg Leu Leu 
    50                  55                  60                  


Arg Arg Val Ile Arg Arg Arg Arg Asn Arg Met Ala Ala Ile Arg Arg 
65                  70                  75                  80  


Leu Leu His Ala Ala Gly Leu Leu Pro Ser Thr Asp Ser Asp Ala Leu 
                85                  90                  95      


Lys Arg Pro Gly His Asp Pro Trp Glu Leu Arg Ala Arg Gly Leu Asp 
            100                 105                 110         


Lys Pro Leu Lys Pro Val Glu Phe Ala Val Val Leu Gly His Ile Ala 
        115                 120                 125             


Lys Arg Arg Gly Phe Lys Ser Ala Ala Lys Arg Lys Ala Thr Asn Ile 
    130                 135                 140                 


Ser Ser Asp Asp Lys Lys Met Leu Thr Ala Leu Glu Ala Thr Arg Glu 
145                 150                 155                 160 


Arg Leu Gly Arg Tyr Arg Thr Val Gly Glu Met Phe Ala Arg Asp Pro 
                165                 170                 175     


Asp Phe Ala Ser Arg Arg Arg Asn Arg Glu Gly Lys Tyr Asp Arg Thr 
            180                 185                 190         


Thr Ala Arg Asp Asp Leu Glu His Glu Val His Ala Leu Phe Ala Ala 
        195                 200                 205             


Gln Arg Arg Leu Gly Gln Gly Phe Ala Ser Pro Glu Leu Glu Glu Ala 
    210                 215                 220                 


Phe Thr Ala Ser Ala Phe His Gln Arg Pro Met Gln Asp Ser Glu Arg 
225                 230                 235                 240 


Leu Val Gly Phe Cys Pro Phe Glu Arg Thr Glu Lys Arg Ala Ala Lys 
                245                 250                 255     


Leu Thr Pro Ser Phe Glu Arg Phe Arg Leu Leu Ala Arg Leu Leu Asn 
            260                 265                 270         


Leu Arg Ile Thr Thr Pro Asp Gly Glu Arg Pro Leu Thr Val Asp Glu 
        275                 280                 285             


Ile Ala Leu Val Thr Arg Asp Leu Gly Lys Thr Ala Lys Leu Ser Ile 
    290                 295                 300                 


Lys Arg Val Arg Thr Leu Ile Gly Leu Glu Asp Asn Gln Arg Phe Thr 
305                 310                 315                 320 


Thr Ile Arg Pro Glu Asp Glu Asp Arg Asp Ile Val Ala Arg Thr Gly 
                325                 330                 335     


Gly Ala Met Thr Gly Thr Ala Thr Leu Arg Lys Ala Leu Gly Glu Ala 
            340                 345                 350         


Leu Trp Thr Asp Met Gln Glu Arg Pro Glu Gln Leu Asp Ala Ile Val 
        355                 360                 365             


Gln Val Leu Ser Phe Phe Glu Ala Asn Glu Thr Ile Thr Glu Lys Leu 
    370                 375                 380                 


Arg Glu Ile Gly Leu Thr Leu Ala Val Leu Asp Val Leu Leu Thr Ala 
385                 390                 395                 400 


Leu Asp Ala Gly Val Phe Ala Lys Phe Lys Gly Ala Ala His Ile Ser 
                405                 410                 415     


Thr Lys Ala Ala Arg Asn Leu Leu Pro His Leu Glu Gln Gly Arg Arg 
            420                 425                 430         


Tyr Asp Glu Ala Cys Thr Met Ala Gly Tyr Asp His Ala Ala Ser Arg 
        435                 440                 445             


Leu Ser His His Gly Gln Ile Val Ala Lys Thr Gln Phe Asn Ala Leu 
    450                 455                 460                 


Val Thr Glu Ile Gly Glu Ser Ile Ala Asn Pro Ile Ala Arg Lys Ala 
465                 470                 475                 480 


Leu Ile Glu Gly Leu Lys Gln Ile Trp Ala Met Arg Asn His Trp Gly 
                485                 490                 495     


Leu Pro Gly Ser Ile His Val Glu Leu Ala Arg Asp Val Gly Asn Ser 
            500                 505                 510         


Ile Glu Lys Arg Arg Glu Ile Glu Lys His Ile Glu Lys Asn Thr Ala 
        515                 520                 525             


Leu Arg Ala Arg Glu Arg Arg Glu Val His Asp Leu Leu Asp Leu Glu 
    530                 535                 540                 


Asp Val Asn Gly Asp Thr Leu Leu Arg Tyr Arg Leu Trp Lys Glu Gln 
545                 550                 555                 560 


Gly Gly Lys Cys Leu Tyr Thr Gly Lys Ala Ile His Ile Arg Gln Ile 
                565                 570                 575     


Ala Ala Thr Asp Asn Ser Val Gln Val Asp His Ile Leu Pro Trp Ser 
            580                 585                 590         


Arg Phe Gly Asp Asp Ser Phe Asn Asn Lys Thr Leu Cys Leu Ala Ser 
        595                 600                 605             


Ala Asn Gln Gln Lys Lys Arg Ser Thr Pro Tyr Glu Trp Leu Ser Gly 
    610                 615                 620                 


Gln Thr Gly Asp Ala Trp Asn Ala Phe Val Gln Arg Ile Glu Thr Asn 
625                 630                 635                 640 


Lys Glu Leu Arg Gly Phe Lys Lys Arg Asn Tyr Leu Leu Lys Asn Ala 
                645                 650                 655     


Lys Glu Ala Glu Glu Lys Phe Arg Ser Arg Asn Leu Asn Asp Thr Arg 
            660                 665                 670         


Tyr Ala Ala Arg Leu Phe Ala Glu Ala Val Lys Leu Leu Tyr Ala Phe 
        675                 680                 685             


Gly Glu Arg Gln Glu Lys Gly Gly Asn Arg Arg Val Phe Thr Arg Pro 
    690                 695                 700                 


Gly Ala Leu Thr Ala Ala Leu Arg Gln Ala Trp Gly Val Glu Ser Leu 
705                 710                 715                 720 


Lys Lys Gln Asp Gly Lys Arg Ile Asn Asp Asp Arg His His Ala Leu 
                725                 730                 735     


Asp Ala Leu Thr Val Ala Ala Val Asp Glu Ala Glu Ile Gln Arg Leu 
            740                 745                 750         


Thr Lys Ser Phe His Glu Trp Glu Gln Gln Gly Leu Gly Arg Pro Leu 
        755                 760                 765             


Arg Arg Val Glu Pro Pro Trp Glu Ser Phe Arg Ala Asp Val Glu Ala 
    770                 775                 780                 


Thr Tyr Pro Glu Val Phe Val Ala Arg Pro Glu Arg Arg Arg Ala Arg 
785                 790                 795                 800 


Gly Glu Gly His Ala Ala Thr Ile Arg Gln Val Lys Glu Arg Glu Cys 
                805                 810                 815     


Thr Pro Ile Val Phe Glu Arg Lys Ala Val Ser Ser Leu Lys Glu Ala 
            820                 825                 830         


Asp Leu Glu Arg Ile Lys Asp Gly Glu Arg Asn Glu Ala Ile Val Glu 
        835                 840                 845             


Ala Ile Arg Ser Trp Ile Ala Thr Gly Arg Pro Ala Asp Ala Pro Pro 
    850                 855                 860                 


Arg Ser Pro Arg Gly Asp Ile Ile Thr Lys Ile Arg Leu Ala Thr Thr 
865                 870                 875                 880 


Ile Lys Ala Ala Val Pro Val Arg Gly Gly Thr Ala Gly Arg Gly Glu 
                885                 890                 895     


Met Val Arg Ala Asp Val Phe Ser Lys Pro Asn Arg Arg Gly Lys Asp 
            900                 905                 910         


Glu Trp Tyr Leu Val Pro Val Tyr Pro His Gln Ile Met Asn Arg Lys 
        915                 920                 925             


Ala Trp Pro Lys Pro Pro Met Arg Ser Ile Val Ala Asn Lys Asp Glu 
    930                 935                 940                 


Asp Glu Trp Thr Glu Val Gly Pro Glu His Gln Phe Arg Phe Ser Leu 
945                 950                 955                 960 


Tyr Pro Arg Ser Asn Ile Glu Ile Ile Arg Pro Ser Gly Glu Val Ile 
                965                 970                 975     


Glu Gly Tyr Phe Val Gly Leu His Arg Asn Thr Gly Ala Leu Ile Pro 
            980                 985                 990         


Thr Pro Val Gly Pro Asp Ser Tyr  Val Ile Ala 
        995                 1000             


<210> 246
<211> 1050
<212> PRT
<213> Gluconacetobacter diazotrophicus

<400> 246
Met Gly Glu Asn Met Ile Asp Glu Ser Leu Thr Phe Gly Ile Asp Leu 
1               5                   10                  15      


Gly Ile Gly Ser Cys Gly Trp Ala Val Leu Arg Arg Pro Ser Ala Phe 
            20                  25                  30          


Gly Arg Lys Gly Val Ile Glu Gly Met Gly Ser Trp Cys Phe Asp Val 
        35                  40                  45              


Pro Glu Thr Ser Lys Glu Arg Thr Pro Thr Asn Gln Ile Arg Arg Ser 
    50                  55                  60                  


Asn Arg Leu Leu Arg Arg Val Ile Arg Arg Arg Arg Asn Arg Met Ala 
65                  70                  75                  80  


Ala Ile Arg Arg Leu Leu His Ala Ala Gly Leu Leu Pro Ser Thr Asp 
                85                  90                  95      


Ser Asp Ala Leu Lys Arg Pro Gly His Asp Pro Trp Glu Leu Arg Ala 
            100                 105                 110         


Arg Gly Leu Asp Lys Pro Leu Lys Pro Val Glu Phe Ala Val Val Leu 
        115                 120                 125             


Gly His Ile Ala Lys Arg Arg Gly Phe Lys Ser Ala Ala Lys Arg Lys 
    130                 135                 140                 


Ala Thr Asn Ile Ser Ser Asp Asp Lys Lys Met Leu Thr Ala Leu Glu 
145                 150                 155                 160 


Ala Thr Arg Glu Arg Leu Gly Arg Tyr Arg Thr Val Gly Glu Met Phe 
                165                 170                 175     


Ala Arg Asp Pro Asp Phe Ala Ser Arg Arg Arg Asn Arg Glu Gly Lys 
            180                 185                 190         


Tyr Asp Arg Thr Thr Ala Arg Asp Asp Leu Glu His Glu Val His Ala 
        195                 200                 205             


Leu Phe Ala Ala Gln Arg Arg Leu Gly Gln Gly Phe Ala Ser Pro Glu 
    210                 215                 220                 


Leu Glu Glu Ala Phe Thr Ala Ser Ala Phe His Gln Arg Pro Met Gln 
225                 230                 235                 240 


Asp Ser Glu Arg Leu Val Gly Phe Cys Pro Phe Glu Arg Thr Glu Lys 
                245                 250                 255     


Arg Ala Ala Lys Leu Thr Pro Ser Phe Glu Arg Phe Arg Leu Leu Ala 
            260                 265                 270         


Arg Leu Leu Asn Leu Arg Ile Thr Thr Pro Asp Gly Glu Arg Pro Leu 
        275                 280                 285             


Thr Val Asp Glu Ile Ala Leu Val Thr Arg Asp Leu Gly Lys Thr Ala 
    290                 295                 300                 


Lys Leu Ser Ile Lys Arg Val Arg Thr Leu Ile Gly Leu Glu Asp Asn 
305                 310                 315                 320 


Gln Arg Phe Thr Thr Ile Arg Pro Glu Asp Glu Asp Arg Asp Ile Val 
                325                 330                 335     


Ala Arg Thr Gly Gly Ala Met Thr Gly Thr Ala Thr Leu Arg Lys Ala 
            340                 345                 350         


Leu Gly Glu Ala Leu Trp Thr Asp Met Gln Glu Arg Pro Glu Gln Leu 
        355                 360                 365             


Asp Ala Ile Val Gln Val Leu Ser Phe Phe Glu Ala Asn Glu Thr Ile 
    370                 375                 380                 


Thr Glu Lys Leu Arg Glu Ile Gly Leu Thr Leu Ala Val Leu Asp Val 
385                 390                 395                 400 


Leu Leu Thr Ala Leu Asp Ala Gly Val Phe Ala Lys Phe Lys Gly Ala 
                405                 410                 415     


Ala His Ile Ser Thr Lys Ala Ala Arg Asn Leu Leu Pro His Leu Glu 
            420                 425                 430         


Gln Gly Arg Arg Tyr Asp Glu Ala Cys Thr Met Ala Gly Tyr Asp His 
        435                 440                 445             


Ala Ala Ser Arg Leu Ser His His Gly Gln Ile Val Ala Lys Thr Gln 
    450                 455                 460                 


Phe Asn Ala Leu Val Thr Glu Ile Gly Glu Ser Ile Ala Asn Pro Ile 
465                 470                 475                 480 


Ala Arg Lys Ala Leu Ile Glu Gly Leu Lys Gln Ile Trp Ala Met Arg 
                485                 490                 495     


Asn His Trp Gly Leu Pro Gly Ser Ile His Val Glu Leu Ala Arg Asp 
            500                 505                 510         


Val Gly Asn Ser Ile Glu Lys Arg Arg Glu Ile Glu Lys His Ile Glu 
        515                 520                 525             


Lys Asn Thr Ala Leu Arg Ala Arg Glu Arg Arg Glu Val His Asp Leu 
    530                 535                 540                 


Leu Asp Leu Glu Asp Val Asn Gly Asp Thr Leu Leu Arg Tyr Arg Leu 
545                 550                 555                 560 


Trp Lys Glu Gln Gly Gly Lys Cys Leu Tyr Thr Gly Lys Ala Ile His 
                565                 570                 575     


Ile Arg Gln Ile Ala Ala Thr Asp Asn Ser Val Gln Val Asp His Ile 
            580                 585                 590         


Leu Pro Trp Ser Arg Phe Gly Asp Asp Ser Phe Asn Asn Lys Thr Leu 
        595                 600                 605             


Cys Leu Ala Ser Ala Asn Gln Gln Lys Lys Arg Ser Thr Pro Tyr Glu 
    610                 615                 620                 


Trp Leu Ser Gly Gln Thr Gly Asp Ala Trp Asn Ala Phe Val Gln Arg 
625                 630                 635                 640 


Ile Glu Thr Asn Lys Glu Leu Arg Gly Phe Lys Lys Arg Asn Tyr Leu 
                645                 650                 655     


Leu Lys Asn Ala Lys Glu Ala Glu Glu Lys Phe Arg Ser Arg Asn Leu 
            660                 665                 670         


Asn Asp Thr Arg Tyr Ala Ala Arg Leu Phe Ala Glu Ala Val Lys Leu 
        675                 680                 685             


Leu Tyr Ala Phe Gly Glu Arg Gln Glu Lys Gly Gly Asn Arg Arg Val 
    690                 695                 700                 


Phe Thr Arg Pro Gly Ala Leu Thr Ala Ala Leu Arg Gln Ala Trp Gly 
705                 710                 715                 720 


Val Glu Ser Leu Lys Lys Gln Asp Gly Lys Arg Ile Asn Asp Asp Arg 
                725                 730                 735     


His His Ala Leu Asp Ala Leu Thr Val Ala Ala Val Asp Glu Ala Glu 
            740                 745                 750         


Ile Gln Arg Leu Thr Lys Ser Phe His Glu Trp Glu Gln Gln Gly Leu 
        755                 760                 765             


Gly Arg Pro Leu Arg Arg Val Glu Pro Pro Trp Glu Ser Phe Arg Ala 
    770                 775                 780                 


Asp Val Glu Ala Thr Tyr Pro Glu Val Phe Val Ala Arg Pro Glu Arg 
785                 790                 795                 800 


Arg Arg Ala Arg Gly Glu Gly His Ala Ala Thr Ile Arg Gln Val Lys 
                805                 810                 815     


Glu Arg Glu Cys Thr Pro Ile Val Phe Glu Arg Lys Ala Val Ser Ser 
            820                 825                 830         


Leu Lys Glu Ala Asp Leu Glu Arg Ile Lys Asp Gly Glu Arg Asn Glu 
        835                 840                 845             


Ala Ile Val Glu Ala Ile Arg Ser Trp Ile Ala Thr Gly Arg Pro Ala 
    850                 855                 860                 


Asp Ala Pro Pro Arg Ser Pro Arg Gly Asp Ile Ile Thr Lys Ile Arg 
865                 870                 875                 880 


Leu Ala Thr Thr Ile Lys Ala Ala Val Pro Val Arg Gly Gly Thr Ala 
                885                 890                 895     


Gly Arg Gly Glu Met Val Arg Ala Asp Val Phe Ser Lys Pro Asn Arg 
            900                 905                 910         


Arg Gly Lys Asp Glu Trp Tyr Leu Val Pro Val Tyr Pro His Gln Ile 
        915                 920                 925             


Met Asn Arg Lys Ala Trp Pro Lys Pro Pro Met Arg Ser Ile Val Ala 
    930                 935                 940                 


Asn Lys Asp Glu Asp Glu Trp Thr Glu Val Gly Pro Glu His Gln Phe 
945                 950                 955                 960 


Arg Phe Ser Leu Tyr Pro Arg Ser Asn Ile Glu Ile Ile Arg Pro Ser 
                965                 970                 975     


Gly Glu Val Ile Glu Gly Tyr Phe Val Gly Leu His Arg Asn Thr Gly 
            980                 985                 990         


Ala Leu Thr Ile Ser Ala His Asn  Asp Pro Lys Ser Ile  His Ser Gly 
        995                 1000                 1005             


Ile Gly  Thr Lys Thr Leu Leu  Ala Ile Ser Lys Tyr  Gln Val Asp 
    1010                 1015                 1020             


Arg Phe  Gly Arg Lys Ser Pro  Val Arg Lys Glu Val  Arg Thr Trp 
    1025                 1030                 1035             


His Gly  Glu Ala Cys Ile Ser  Pro Thr Pro Pro Gly  
    1040                 1045                 1050 


<210> 247
<211> 1371
<212> PRT
<213> Gordonibacter pamelaeae


<220>
<223> Gordonibacter pamelaeae 7-10-1-b

<400> 247
Met Asn Leu Arg Asn Val Glu Ser Tyr Gln Val Gly Leu Asp Ile Gly 
1               5                   10                  15      


Thr Gly Ser Val Gly Trp Ala Val Leu Asp Asp Asn Gly Asp Leu Cys 
            20                  25                  30          


Arg Phe Lys Gly Lys Pro Thr Trp Gly Ser Arg Val Phe Pro Thr Ala 
        35                  40                  45              


Glu Thr Ala Ala Glu Ala Arg Val His Arg Gly Gln Arg Arg Arg Tyr 
    50                  55                  60                  


Asp Arg Arg Arg Gln Arg Ile Asp Leu Leu Gln Arg Phe Phe Ala Asp 
65                  70                  75                  80  


Glu Val Ala Lys Val Asp Pro Glu Phe Phe Ile Arg Leu Asn Gln Ala 
                85                  90                  95      


Arg Leu His Pro Glu Asn Arg Asp Pro Ala His Ala Asp Tyr Arg Trp 
            100                 105                 110         


Pro Leu Phe Asn Gly Ser Asn Phe Thr Glu Lys Asp Tyr Tyr Arg Gln 
        115                 120                 125             


Phe Pro Thr Ile Tyr His Leu Arg Ala His Leu Leu Lys Ser Asp Glu 
    130                 135                 140                 


Pro Ala Asp Ile Arg Leu Val Tyr Leu Ala Leu His Asn Ile Val Lys 
145                 150                 155                 160 


His Arg Gly Asn Phe Leu His Gln Asp Asn Pro Ser Leu Ser Ala Arg 
                165                 170                 175     


Asn Ala Asn Val Gly Asp Ala Val Glu Ala Leu Cys Leu Ala Leu Asp 
            180                 185                 190         


Glu Trp Cys Gly Ala His Asp Val Glu Cys Ala Cys Asp Glu Ala Ala 
        195                 200                 205             


Leu Ala Glu Ala Leu Gly Asp Ala Ser Leu Arg Pro Gly Glu Lys Arg 
    210                 215                 220                 


Glu Arg Ala Glu Ala Ala Leu Gly Val Glu Lys Ala His Lys Lys Leu 
225                 230                 235                 240 


Ala Lys Ala Val Ser Ser Ala Val Val Gly Tyr Ala Ala Glu Phe Gly 
                245                 250                 255     


His Val Phe Phe Ala Glu Ser Glu Gly Ser Lys Phe Ala Leu Ser Asn 
            260                 265                 270         


Asp Glu Lys Val Glu Ala Tyr Val Cys Pro Asp Glu Gly Arg Asp Leu 
        275                 280                 285             


Phe Asp Ala Met Arg Ala Val His Ser Ser Tyr Val Leu Met Gly Ile 
    290                 295                 300                 


Leu Ser Glu Ala Gln Gly Glu Leu Leu Ser Val Cys Lys Val Gly Glu 
305                 310                 315                 320 


Tyr Glu Arg Tyr Lys Arg Asp Leu Glu Thr Leu Lys Ser Leu Val Arg 
                325                 330                 335     


Ala Tyr Gly Pro Glu Arg Tyr Asp Glu Phe Phe Cys Gly Pro Phe Tyr 
            340                 345                 350         


Glu Gly Thr Arg Asp Tyr Asp Pro Gly Lys Ala Gln Gly Tyr Thr Lys 
        355                 360                 365             


Tyr Asn Leu Gly Ala Ser Lys Leu Ser His Glu Asp Phe Leu Lys Glu 
    370                 375                 380                 


Val Gln Lys Leu Leu Lys Asp Ile Gly Ala Gln Ala Asp Glu Arg Tyr 
385                 390                 395                 400 


Ala Asp Ile Glu Arg Ala Ile Glu Ala Gly Ala Phe Leu Arg Arg Leu 
                405                 410                 415     


Lys Thr Ser Asp Asn Gly Thr Ile Pro Tyr Gln Leu His Leu Glu Glu 
            420                 425                 430         


Met Asp Ala Ile Ile Glu Arg Gln Ala Ala Phe Tyr Pro Phe Leu Ala 
        435                 440                 445             


Gln Glu Lys Asp Lys Leu Lys Ser Leu Val Ser Phe Arg Ile Pro Tyr 
    450                 455                 460                 


Tyr Val Gly Pro Leu Thr Gln Lys Asn Ala Ala Arg Asp Gly Lys Gly 
465                 470                 475                 480 


Glu Ala Arg Phe Ala Trp Ser Ser Arg Lys Pro Gly Met Glu Asp Ala 
                485                 490                 495     


Arg Val Tyr Pro Trp Asn Trp Glu Asp Val Ile Asp Lys Asp Gln Ser 
            500                 505                 510         


Ala Glu Asp Phe Ile Arg Arg Met Thr Gly Thr Cys Thr Tyr Leu Lys 
        515                 520                 525             


Gly Glu Pro Val Leu Ala Arg Cys Ser Leu Asp Tyr Glu Leu Phe Cys 
    530                 535                 540                 


Val Leu Asn Glu Leu Ala Gly Ala Arg Trp Thr Gln Asp Gly Asp Lys 
545                 550                 555                 560 


Ser Tyr Arg Phe Asp Ala Ala Asp Arg Leu Gly Ile Val Glu Asp Leu 
                565                 570                 575     


Phe Lys Lys Arg Lys Arg Val Thr Tyr Glu Ala Ala Glu Lys Trp Leu 
            580                 585                 590         


Ala Arg Thr His Gly Pro Glu Ser Gly Lys Ser Ala Gly Gly Ala Tyr 
        595                 600                 605             


His Val Ser Gly Gly Gln Gly Glu Asp Ala Phe Glu Ser Gln Leu Ser 
    610                 615                 620                 


Ser His Tyr Asp Phe Cys Lys Ile Leu Gly Val Asp Glu Leu Ser Asp 
625                 630                 635                 640 


Ala Asp Glu Ala Met Ala Glu Asp Ile Ile Leu Trp Asn Thr Val Phe 
                645                 650                 655     


Glu Asp Arg Ser Ile Leu Lys Arg Lys Ile Lys Leu Ala Tyr Gly Asp 
            660                 665                 670         


Arg Leu Gly Asp Ala Gln Val Arg Lys Leu Cys Gln Lys Arg Tyr Thr 
        675                 680                 685             


Gly Trp Gly Arg Leu Ser Gly Glu Leu Leu Arg Gly Leu Arg Ser Ala 
    690                 695                 700                 


Thr Asp Asn Gly Pro Lys Thr Ile Met Asp Ile Leu Leu Glu Gly Asp 
705                 710                 715                 720 


Pro Asn His Ala Arg Arg Met Gly Ala Ala Met Asn Leu Met Glu Ile 
                725                 730                 735     


Leu His Asp Asp Leu Leu Glu Phe Gln Ala Lys Ile Asp Glu His Asn 
            740                 745                 750         


Arg Glu Arg Ala Leu Ala Val Gly Gly Met Ser Val Asp Glu Val Thr 
        755                 760                 765             


Gly Ser Pro Ala Leu Arg Arg Gly Ile Asn Gln Ala Leu Arg Val Val 
    770                 775                 780                 


Asp Glu Ile Ala Gly Ile Ala Gly Lys Pro Pro Ala His Ile Tyr Val 
785                 790                 795                 800 


Glu Val Thr Arg Asp Glu Gly Ala Arg Asn Lys Gly Arg Arg Thr Thr 
                805                 810                 815     


Ser Arg Tyr Arg Ala Leu Glu Ala Ala Leu Ser Ser Ile Lys Ala Gln 
            820                 825                 830         


Cys Ala Asp Val Tyr Ala Glu Leu Lys Glu Arg Asp Pro Arg Ala Leu 
        835                 840                 845             


Asp Asp Glu Arg Leu Thr Leu Tyr Phe Met Gln Cys Gly Lys Cys Met 
    850                 855                 860                 


Tyr Ser Gly Asp Ala Leu Asp Ile Asn Lys Leu Gln Thr Tyr Gln Val 
865                 870                 875                 880 


Asp His Ile Leu Pro Gln Ser Tyr Val Lys Asp Asp Ser Phe Glu Asn 
                885                 890                 895     


Lys Val Leu Val Arg Pro Asp Thr Asn Gln Arg Lys Gly Asp Thr Leu 
            900                 905                 910         


Leu Leu Asp Glu Arg Leu Ile Ala Arg Met Arg Gly Phe Trp Arg Thr 
        915                 920                 925             


Leu Arg Asp Ala Glu Leu Ile Gly Glu Lys Lys Phe Asn Asn Leu Thr 
    930                 935                 940                 


Arg Thr Ser Val Ser Asp Glu Gln Met Lys Lys Phe Val Ser Arg Gln 
945                 950                 955                 960 


Leu Val Glu Thr Gly Gln Met Val Lys Gln Val Gln Gln Leu Leu Gln 
                965                 970                 975     


Ala Arg Tyr Pro Glu Ser Glu Val Gln Pro Val Lys Ala Gly Val Ser 
            980                 985                 990         


His Gln Leu Arg Val Gly Cys Ala  Leu Ala Lys Ser Arg  Glu Ile Asn 
        995                 1000                 1005             


Asp Phe  His His Ala His Asp  Ala Tyr Leu Ala Cys  Gln Val Gly 
    1010                 1015                 1020             


Arg Phe  Val Gln Tyr Arg His  Ser Ala Val Tyr Ser  Glu Pro Val 
    1025                 1030                 1035             


Lys Met  Ala Ala Val Val Lys  Gln Phe Ile Lys Lys  Gln Ala Glu 
    1040                 1045                 1050             


Asp Tyr  Arg Arg Thr Arg Glu  Leu Pro Gly Ser Asp  Gly Phe Ile 
    1055                 1060                 1065             


Val Ser  Ser Phe Met Thr Pro  Gly Phe Asp Val Lys  Thr Gly Glu 
    1070                 1075                 1080             


Val Phe  Arg Asp Ala Trp Asp  Ala Gly Ala Glu Ile  Asp Arg Ile 
    1085                 1090                 1095             


Arg Arg  Cys Phe Asp Tyr Lys  Asp Cys Phe Ile Ser  Arg Met Pro 
    1100                 1105                 1110             


Glu Glu  Thr His Gly Ala Phe  Trp Asp Ala Thr Ile  Tyr Ser Pro 
    1115                 1120                 1125             


Arg Ala  Ala Gly Lys Thr Leu  Ser Leu Pro Leu Lys  Arg Gly Leu 
    1130                 1135                 1140             


Asp Pro  Arg Lys Tyr Gly Ser  Tyr Ser Arg Glu Gln  Phe Ala Tyr 
    1145                 1150                 1155             


Phe Phe  Val Tyr Glu Ala Val  Lys Pro Lys Lys Lys  Gln Arg Val 
    1160                 1165                 1170             


Leu Glu  Phe Ala Pro Val Pro  Val Arg Val Ala Ser  Ala Leu Ala 
    1175                 1180                 1185             


Asn Asp  Pro Asp Ala Leu Glu  Asp Tyr Ala Arg Glu  Leu Ala Glu 
    1190                 1195                 1200             


Ala Glu  Gly Leu Val Phe Glu  Arg Ile Arg Arg Arg  Lys Val Tyr 
    1205                 1210                 1215             


Lys Tyr  Gln Gln Ile Ile Val  Gly Asp Ser Arg Leu  Tyr Val Thr 
    1220                 1225                 1230             


Gly Arg  Glu Glu Val Arg Asn  Ala Arg Gln Leu Ala  Phe Ser Gln 
    1235                 1240                 1245             


Asp Glu  Thr Lys Leu Ile Cys  Arg Ile Glu Gln Gly  Glu Glu Cys 
    1250                 1255                 1260             


Glu Glu  Gly Glu Leu Leu Asp  Leu Phe Arg Ser Met  Gln Arg Lys 
    1265                 1270                 1275             


Tyr Leu  Ala Cys Ala Pro Arg  Leu Ala Arg Leu Met  Lys Val Ala 
    1280                 1285                 1290             


Glu Met  Glu Glu Gly Phe Ile  Ala Ala Thr Ala Ser  Gly Lys Arg 
    1295                 1300                 1305             


Glu Val  Leu Leu Ser Leu Thr  Ser Ile Ala Ala Ala  His Arg Asn 
    1310                 1315                 1320             


Ser Ile  Asp Leu Lys Pro Ile  Gly Arg Lys Gly Ser  Ser Gly Gln 
    1325                 1330                 1335             


Met Lys  Ile Thr Phe Ser Lys  Glu Leu Ser Thr Asn  Gly Ile Leu 
    1340                 1345                 1350             


Phe Val  Asp Ser Ser Val Thr  Gly Met Phe Glu Arg  Arg Cys Arg 
    1355                 1360                 1365             


Leu Gly  Leu 
    1370     


<210> 248
<211> 1054
<212> PRT
<213> Haemophilus parainfluenzae


<220>
<223> Haemophilus parainfluenzae ATCC 33392

<400> 248
Met Glu Asn Lys Asn Leu Asn Tyr Ile Leu Gly Leu Asp Leu Gly Ile 
1               5                   10                  15      


Ala Ser Val Gly Trp Ala Val Val Glu Ile Asp Glu Lys Glu Asn Pro 
            20                  25                  30          


Leu Arg Leu Ile Asp Val Gly Val Arg Thr Phe Glu Arg Ala Glu Val 
        35                  40                  45              


Pro Lys Thr Gly Glu Ser Leu Ala Leu Ser Arg Arg Leu Ala Arg Ser 
    50                  55                  60                  


Ala Arg Arg Leu Thr Gln Arg Arg Val Ala Arg Leu Lys Lys Ala Lys 
65                  70                  75                  80  


Arg Leu Leu Lys Ser Glu Asn Ile Leu Leu Ser Thr Asp Glu Arg Leu 
                85                  90                  95      


Pro His Gln Val Trp Gln Leu Arg Val Glu Gly Leu Asp His Lys Leu 
            100                 105                 110         


Glu Arg Gln Glu Trp Ala Ala Val Leu Leu His Leu Ile Lys His Arg 
        115                 120                 125             


Gly Tyr Leu Ser Gln Arg Lys Asn Glu Ser Lys Ser Glu Asn Lys Glu 
    130                 135                 140                 


Leu Gly Ala Leu Leu Ser Gly Val Asp Asn Asn His Lys Leu Leu Gln 
145                 150                 155                 160 


Gln Ala Thr Tyr Arg Ser Pro Ala Glu Leu Ala Val Lys Lys Phe Glu 
                165                 170                 175     


Val Glu Glu Gly His Ile Arg Asn Gln Gln Gly Ala Tyr Thr His Thr 
            180                 185                 190         


Phe Ser Arg Leu Asp Leu Leu Ala Glu Met Glu Leu Leu Phe Ser Arg 
        195                 200                 205             


Gln Gln His Phe Gly Asn Pro Phe Ala Ser Glu Lys Leu Leu Glu Asn 
    210                 215                 220                 


Leu Thr Ala Leu Leu Met Trp Gln Lys Pro Ala Leu Ser Gly Glu Ala 
225                 230                 235                 240 


Ile Leu Lys Met Leu Gly Lys Cys Thr Phe Glu Asp Glu Tyr Lys Ala 
                245                 250                 255     


Ala Lys Asn Thr Tyr Ser Ala Glu Arg Phe Val Trp Ile Thr Lys Leu 
            260                 265                 270         


Asn Asn Leu Arg Ile Gln Glu Asn Gly Leu Glu Arg Ala Leu Asn Asp 
        275                 280                 285             


Asn Glu Arg Leu Ala Leu Met Glu Gln Pro Tyr Asp Lys Asn Arg Leu 
    290                 295                 300                 


Phe Tyr Ser Gln Val Arg Ser Ile Leu Lys Leu Ser Asp Glu Ala Ile 
305                 310                 315                 320 


Phe Lys Gly Leu Arg Tyr Ser Gly Glu Asp Lys Lys Ala Ile Glu Thr 
                325                 330                 335     


Lys Ala Val Leu Met Glu Met Lys Ala Tyr His Gln Ile Arg Lys Val 
            340                 345                 350         


Leu Glu Gly Asn Asn Leu Lys Ala Glu Trp Ala Glu Leu Lys Ala Asn 
        355                 360                 365             


Pro Thr Leu Leu Asp Glu Ile Gly Thr Ala Phe Ser Leu Tyr Lys Thr 
    370                 375                 380                 


Asp Glu Asp Ile Ser Ala Tyr Leu Ala Gly Lys Leu Ser Gln Pro Val 
385                 390                 395                 400 


Leu Asn Ala Leu Leu Glu Asn Leu Ser Phe Asp Lys Phe Ile Gln Leu 
                405                 410                 415     


Ser Leu Lys Ala Leu Tyr Lys Leu Leu Pro Leu Met Gln Gln Gly Leu 
            420                 425                 430         


Arg Tyr Asp Glu Ala Cys Arg Glu Ile Tyr Gly Asp His Tyr Gly Lys 
        435                 440                 445             


Lys Thr Glu Glu Asn His His Phe Leu Pro Gln Ile Pro Ala Asp Glu 
    450                 455                 460                 


Ile Arg Asn Pro Val Val Leu Arg Thr Leu Thr Gln Ala Arg Lys Val 
465                 470                 475                 480 


Ile Asn Gly Val Val Arg Leu Tyr Gly Ser Pro Ala Arg Ile His Ile 
                485                 490                 495     


Glu Thr Gly Arg Glu Val Gly Lys Ser Tyr Lys Asp Arg Arg Glu Leu 
            500                 505                 510         


Glu Lys Arg Gln Glu Glu Asn Arg Lys Gln Arg Glu Asn Ala Ile Lys 
        515                 520                 525             


Glu Phe Lys Glu Tyr Phe Pro His Phe Ala Gly Glu Pro Lys Ala Lys 
    530                 535                 540                 


Asp Ile Leu Lys Met Arg Leu Tyr Lys Gln Gln Asn Ala Lys Cys Leu 
545                 550                 555                 560 


Tyr Ser Gly Lys Pro Ile Glu Leu His Arg Leu Leu Glu Lys Gly Tyr 
                565                 570                 575     


Val Glu Val Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp Ser 
            580                 585                 590         


Phe Asn Asn Lys Val Leu Val Leu Ala Asn Glu Asn Gln Asn Lys Gly 
        595                 600                 605             


Asn Leu Thr Pro Phe Glu Trp Leu Asp Gly Lys His Asn Ser Glu Arg 
    610                 615                 620                 


Trp Arg Ala Phe Lys Ala Leu Val Glu Thr Ser Ala Phe Pro Tyr Ala 
625                 630                 635                 640 


Lys Lys Gln Arg Ile Leu Ser Gln Lys Leu Asp Glu Lys Gly Phe Ile 
                645                 650                 655     


Glu Arg Asn Leu Asn Asp Thr Arg Tyr Val Ala Arg Phe Leu Cys Asn 
            660                 665                 670         


Phe Ile Ala Asp Asn Met His Leu Thr Gly Glu Gly Lys Arg Lys Val 
        675                 680                 685             


Phe Ala Ser Asn Gly Gln Ile Thr Ala Leu Leu Arg Ser Arg Trp Gly 
    690                 695                 700                 


Leu Ala Lys Ser Arg Glu Asp Asn Asp Arg His His Ala Leu Asp Ala 
705                 710                 715                 720 


Val Val Val Ala Cys Ser Thr Val Ala Met Gln Gln Lys Ile Thr Arg 
                725                 730                 735     


Phe Val Arg Phe Glu Ala Gly Asp Val Phe Thr Gly Glu Arg Ile Asp 
            740                 745                 750         


Arg Glu Thr Gly Glu Ile Ile Pro Leu His Phe Pro Thr Pro Trp Gln 
        755                 760                 765             


Phe Phe Lys Gln Glu Val Glu Ile Arg Ile Phe Ser Asp Asn Pro Lys 
    770                 775                 780                 


Leu Glu Leu Glu Asn Arg Leu Pro Asp Arg Pro Gln Ala Asn His Glu 
785                 790                 795                 800 


Phe Val Gln Pro Leu Phe Val Ser Arg Met Pro Thr Arg Lys Met Thr 
                805                 810                 815     


Gly Gln Gly His Met Glu Thr Val Lys Ser Ala Lys Arg Leu Asn Glu 
            820                 825                 830         


Gly Ile Ser Val Ile Lys Met Pro Leu Thr Lys Leu Lys Leu Lys Asp 
        835                 840                 845             


Leu Glu Leu Met Val Asn Arg Glu Arg Glu Lys Asp Leu Tyr Asp Thr 
    850                 855                 860                 


Leu Lys Ala Arg Leu Glu Ala Phe Asn Asp Asp Pro Ala Lys Ala Phe 
865                 870                 875                 880 


Ala Glu Pro Phe Ile Lys Lys Gly Gly Ala Ile Val Lys Ser Val Arg 
                885                 890                 895     


Val Glu Gln Ile Gln Lys Ser Gly Val Leu Val Arg Glu Gly Asn Gly 
            900                 905                 910         


Val Ala Asp Asn Ala Ser Met Val Arg Val Asp Val Phe Thr Lys Gly 
        915                 920                 925             


Gly Lys Tyr Phe Leu Val Pro Ile Tyr Thr Trp Gln Val Ala Lys Gly 
    930                 935                 940                 


Ile Leu Pro Asn Lys Ala Ala Thr Gln Tyr Lys Asp Glu Glu Asp Trp 
945                 950                 955                 960 


Glu Val Met Asp Asn Ser Ala Thr Phe Lys Phe Ser Leu His Pro Asn 
                965                 970                 975     


Asp Leu Val Lys Leu Val Thr Lys Lys Lys Thr Ile Leu Gly Tyr Phe 
            980                 985                 990         


Asn Gly Leu Asn Arg Ala Thr Gly  Asn Ile Asp Ile Lys  Glu His Asp 
        995                 1000                 1005             


Leu Asp  Lys Ser Lys Gly Lys  Gln Gly Ile Phe Glu  Gly Val Gly 
    1010                 1015                 1020             


Ile Lys  Leu Ala Leu Ser Phe  Glu Lys Tyr Gln Val  Asp Glu Leu 
    1025                 1030                 1035             


Gly Lys  Asn Ile Arg Leu Cys  Lys Pro Ser Lys Arg  Gln Pro Val 
    1040                 1045                 1050             


Arg 
    


<210> 249
<211> 1052
<212> PRT
<213> Haemophilus sputorum


<220>
<223> Haemophilus sputorum CCUG 13788

<400> 249
Met Lys Asn Thr Ser Leu Asn Tyr Val Leu Gly Leu Asp Leu Gly Ile 
1               5                   10                  15      


Ser Ser Val Gly Trp Ala Val Val Glu Ile Asp Glu Lys Glu Asn Pro 
            20                  25                  30          


Leu Ser Leu Ile Asp Val Gly Val Arg Thr Phe Glu Arg Ala Glu Thr 
        35                  40                  45              


Gln Lys Gly Glu Ser Leu Ala Leu Ala Arg Arg Leu Ala Arg Ser Ala 
    50                  55                  60                  


Arg Arg Leu Thr Gln Arg Arg Val Ala Arg Leu Lys Lys Ala Lys Arg 
65                  70                  75                  80  


Leu Leu Lys Ser Glu Asn Ile Leu Leu Ser Thr Asp Glu Cys Leu Pro 
                85                  90                  95      


His Gln Val Trp Gln Leu Arg Val Glu Gly Leu Glu Arg Lys Leu Glu 
            100                 105                 110         


Arg Gln Glu Trp Ala Ala Val Leu Leu His Leu Ile Lys His Arg Gly 
        115                 120                 125             


Tyr Leu Ser Gln Arg Lys Asn Glu Ser Lys Ser Glu Asn Lys Glu Leu 
    130                 135                 140                 


Gly Ala Leu Leu Ser Gly Val Ala Asn Asn His Lys Leu Leu Gln Gln 
145                 150                 155                 160 


Thr Thr Tyr Arg Thr Pro Ala Glu Leu Ala Val Lys Lys Phe Glu Val 
                165                 170                 175     


Glu Glu Gly His Ile Arg Asn Gln Gln Gly Ser Tyr Thr His Thr Phe 
            180                 185                 190         


Ser Arg Leu Asp Leu Leu Ser Glu Met Glu Leu Leu Phe Ser Arg Gln 
        195                 200                 205             


Gln His Phe Gly Asn Pro Phe Thr Ser Glu Lys Leu Leu Glu Asn Leu 
    210                 215                 220                 


Thr Ala Leu Leu Met Trp Gln Lys Pro Ala Leu Ser Gly Asp Ala Ile 
225                 230                 235                 240 


Leu Lys Met Leu Gly Lys Cys Thr Phe Glu Asn Glu Tyr Lys Ala Ala 
                245                 250                 255     


Lys His Thr Tyr Ser Ala Glu Arg Phe Ile Trp Ile Thr Lys Leu Asn 
            260                 265                 270         


Asn Leu Arg Ile Gln Glu Asn Gly Leu Glu Arg Ala Leu Asn Asp Asn 
        275                 280                 285             


Glu Arg Leu Ala Leu Met Lys Gln Pro Tyr Glu Lys Ala Lys Leu Thr 
    290                 295                 300                 


Tyr Ala Gln Val Arg Ser Ile Leu Asn Leu Ser Asp Glu Ala Ile Phe 
305                 310                 315                 320 


Lys Gly Leu Arg Tyr Ser Gly Glu Asp Lys Lys Thr Ser Glu Thr Lys 
                325                 330                 335     


Thr Val Leu Met Glu Met Lys Ala Tyr His Gln Ile Arg Leu Ala Leu 
            340                 345                 350         


Glu Lys Asn Asp Leu Lys Thr Glu Trp Ala Glu Leu Lys Val Asn Ser 
        355                 360                 365             


Ser Leu Leu Asp Glu Ile Gly Thr Ala Phe Ser Leu Tyr Lys Thr Asp 
    370                 375                 380                 


Glu Asp Ile Ser Thr Cys Leu Ala Gly Lys Leu Ser Gln Pro Val Leu 
385                 390                 395                 400 


Asn Ala Leu Leu Glu Asn Leu Asn Phe Asp Lys Phe Ile Gln Leu Ser 
                405                 410                 415     


Leu Lys Ala Leu His Lys Ile Leu Pro Leu Met Gln Gln Gly Leu Arg 
            420                 425                 430         


Tyr Asp Glu Ala Cys Ala Glu Ile Tyr Gly Asp His Tyr Gly Lys Lys 
        435                 440                 445             


Thr Glu Glu Asn His Leu Leu Leu Pro Gln Ile Pro Ala Asp Glu Ile 
    450                 455                 460                 


Arg Asn Pro Val Val Leu Arg Thr Leu Thr Gln Ala Arg Lys Val Ile 
465                 470                 475                 480 


Asn Gly Val Val Arg Leu Tyr Ser Ser Pro Ala Arg Ile His Ile Glu 
                485                 490                 495     


Thr Gly Arg Glu Val Gly Lys Ser Tyr Gln Asp Arg Arg Glu Leu Glu 
            500                 505                 510         


Lys Arg Gln Glu Glu Asn Arg Lys Gln Arg Glu Lys Ala Ile Ser Glu 
        515                 520                 525             


Ile Lys Thr Leu Phe Pro Asn Phe Ser Gly Glu Pro Lys Ala Lys Asp 
    530                 535                 540                 


Ile Leu Lys Met Arg Leu Tyr Tyr Gln Gln Asn Ala Lys Cys Leu Tyr 
545                 550                 555                 560 


Ser Gly Lys Pro Leu Glu Leu His Arg Leu Leu Glu Gln Gly Tyr Val 
                565                 570                 575     


Glu Ile Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp Ser Phe 
            580                 585                 590         


Asn Asn Lys Val Leu Val Leu Ala Asn Glu Asn Gln Asn Lys Gly Asn 
        595                 600                 605             


Leu Thr Pro Phe Glu Trp Leu Asp Gly Lys Asn Asn Ser Glu Arg Trp 
    610                 615                 620                 


Lys Ala Phe Lys Ala Leu Val Glu Thr Ser Ala Phe Pro Tyr Thr Lys 
625                 630                 635                 640 


Lys Gln Arg Ile Leu Ser Gln Lys Leu Asp Glu Lys Gly Phe Ile Glu 
                645                 650                 655     


Arg Asn Leu Asn Asp Thr Arg Tyr Val Ala Arg Phe Leu Cys Asn Phe 
            660                 665                 670         


Ile Ala Asp Asn Met His Leu Thr Gly Glu Gly Lys Arg Lys Val Phe 
        675                 680                 685             


Ala Ser Asn Gly Gln Ile Thr Ala Leu Leu Arg Gly Arg Trp Gly Leu 
    690                 695                 700                 


Ala Lys Ser Arg Glu Asp Asn Asp Arg His His Ala Leu Asp Ala Val 
705                 710                 715                 720 


Val Val Ala Cys Ser Thr Val Ser Met Gln Gln Lys Ile Thr Arg Phe 
                725                 730                 735     


Val Arg Phe Glu Glu Gly Asn Val Phe Thr Gly Glu Arg Ile Asp Arg 
            740                 745                 750         


Glu Thr Gly Glu Ile Ile Pro Leu His Phe Pro Ala Pro Trp Lys Phe 
        755                 760                 765             


Phe Arg Glu Glu Val Glu Ile Arg Ile Phe Ser Asp Asn Pro Lys Leu 
    770                 775                 780                 


Glu Leu Glu Asn Arg Leu Ile Ala Arg Pro Gln Ala Asn His Glu Phe 
785                 790                 795                 800 


Val Gln Pro Leu Phe Val Ser Arg Met Pro Thr Arg Lys Met Ile Gly 
                805                 810                 815     


Gln Gly His Met Glu Thr Ile Lys Ser Ala Lys Arg Leu Asn Glu Gly 
            820                 825                 830         


Leu Ser Val Ile Lys Met Leu Leu Thr Lys Leu Arg Leu Lys Asp Leu 
        835                 840                 845             


Glu Ser Met Val Asn Arg Glu Arg Glu Lys Glu Leu Tyr Glu Ala Leu 
    850                 855                 860                 


Lys Ala Arg Leu Glu Ala Phe Asn Asp Glu Pro Ala Lys Ala Phe Ala 
865                 870                 875                 880 


Glu Pro Phe Met Lys Lys Gly Gly Ala Ile Val Lys Ser Val Arg Val 
                885                 890                 895     


Glu Gln Val Gln Lys Ser Gly Val Leu Val Arg Asp Gly Asn Gly Val 
            900                 905                 910         


Ala Asp Asn Ala Ser Met Val Arg Val Asp Val Phe Thr Lys Gly Gly 
        915                 920                 925             


Lys Tyr Phe Leu Val Pro Ile Tyr Thr Trp Gln Val Ala Lys Gly Ile 
    930                 935                 940                 


Leu Pro Asn Lys Ala Val Ile Gln Gly Lys Asn Glu Glu Asp Trp Glu 
945                 950                 955                 960 


Val Met Asp Asp Ala Thr Phe Arg Phe Ser Leu His Gln Asn Asp Leu 
                965                 970                 975     


Val Lys Leu Val Thr Lys Lys Lys Thr Ile Phe Gly Tyr Phe Asn Gly 
            980                 985                 990         


Leu Asn Arg Ala Thr Gly Asn Ile  Asp Ile Lys Glu His  Asp Leu Glu 
        995                 1000                 1005             


Lys Ser  Lys Val Lys Asp Gly  Ile His Gln Ser Ile  Gly Ile Lys 
    1010                 1015                 1020             


Leu Ala  Leu Ser Phe Glu Lys  Tyr Gln Val Asp Glu  Leu Gly Lys 
    1025                 1030                 1035             


Asn Ile  Arg Leu Cys Lys Ser  Ser Lys Arg Gln Ala  Val Arg 
    1040                 1045                 1050         


<210> 250
<211> 1052
<212> PRT
<213> Haemophilus parainfluenzae

<400> 250
Met Glu Asn Lys Asn Leu His Tyr Ile Leu Gly Leu Asp Leu Gly Ile 
1               5                   10                  15      


Ala Ser Val Gly Trp Ala Val Val Glu Ile Asp Glu Lys Glu Asn Pro 
            20                  25                  30          


Leu Arg Leu Ile Asp Val Gly Val Arg Thr Phe Glu Arg Ala Glu Thr 
        35                  40                  45              


Gln Lys Gly Glu Ser Leu Ala Leu Ser Arg Arg Ser Ala Arg Ser Ala 
    50                  55                  60                  


Arg Arg Leu Thr Gln Arg Arg Val Ala Arg Leu Lys Lys Ala Lys Arg 
65                  70                  75                  80  


Leu Leu Lys Ser Glu Asn Ile Leu Leu Ser Thr Asp Glu Arg Leu Pro 
                85                  90                  95      


His Gln Val Trp Gln Leu Arg Val Glu Gly Leu Asp Arg Lys Leu Glu 
            100                 105                 110         


Arg Gln Glu Trp Ala Ala Val Leu Leu His Leu Ile Lys His Arg Gly 
        115                 120                 125             


Tyr Leu Ser Gln Arg Lys Asn Glu Ser Lys Ser Glu Asn Lys Glu Leu 
    130                 135                 140                 


Gly Ala Leu Leu Ser Gly Val Ala Ser Asn His Glu Leu Leu Gln Gln 
145                 150                 155                 160 


Ala Thr Tyr Arg Thr Pro Ala Glu Leu Ala Val Lys Lys Phe Glu Val 
                165                 170                 175     


Glu Glu Gly His Ile Arg Asn Gln Gln Gly Ala Tyr Thr His Thr Phe 
            180                 185                 190         


Ser Arg Leu Asp Leu Leu Ala Glu Met Glu Leu Leu Phe Ser Arg Gln 
        195                 200                 205             


Gln His Phe Gly Asn Pro Phe Ala Ser Glu Lys Leu Leu Glu Asn Leu 
    210                 215                 220                 


Thr Ala Leu Leu Met Trp Gln Lys Pro Ala Leu Ser Gly Glu Asp Ile 
225                 230                 235                 240 


Leu Lys Met Leu Gly Lys Cys Thr Phe Glu Asp Glu Tyr Lys Ala Ala 
                245                 250                 255     


Lys Asn Thr Tyr Thr Ala Glu Arg Phe Val Trp Ile Thr Lys Leu Asn 
            260                 265                 270         


Asn Leu Arg Ile Gln Glu Asn Gly Leu Glu Arg Ala Leu Ser Asp Asn 
        275                 280                 285             


Glu Arg Leu Met Leu Ile Glu Gln Pro Tyr Glu Lys Ala Lys Leu Thr 
    290                 295                 300                 


Tyr Ala Gln Val Arg Ser Ile Leu Asn Leu Ser Asp Asp Ala Ile Phe 
305                 310                 315                 320 


Lys Gly Val Arg Tyr Ser Gly Glu Asp Lys Lys Ala Ile Glu Thr Lys 
                325                 330                 335     


Thr Thr Leu Met Glu Met Lys Ala Tyr His Gln Ile Arg Lys Val Leu 
            340                 345                 350         


Glu Gly Asn Asn Leu Lys Ala Glu Trp Val Ala Leu Lys Ala Asn Pro 
        355                 360                 365             


Thr Leu Leu Asp Glu Ile Gly Thr Ala Phe Ser Leu Tyr Lys Thr Asp 
    370                 375                 380                 


Glu Asp Ile Ser Ala Tyr Leu Ala Gly Lys Leu Ser Gln Pro Val Leu 
385                 390                 395                 400 


Asn Ala Leu Leu Glu Asn Leu Ser Phe Asp Lys Phe Ile Gln Leu Ser 
                405                 410                 415     


Leu Lys Ala Leu Tyr Lys Leu Leu Pro Leu Met Gln Gln Gly Leu Arg 
            420                 425                 430         


Tyr Asp Glu Ala Cys Arg Glu Ile Tyr Gly Asp His Tyr Gly Lys Lys 
        435                 440                 445             


Thr Glu Glu Thr His His Phe Leu Pro Gln Ile Pro Ala Asp Glu Ile 
    450                 455                 460                 


Arg Asn Pro Val Val Leu Arg Thr Leu Thr Gln Ala Arg Lys Val Ile 
465                 470                 475                 480 


Asn Gly Val Val Arg Leu Tyr Gly Ser Pro Ala Arg Ile His Ile Glu 
                485                 490                 495     


Thr Gly Arg Glu Val Gly Lys Ser Tyr Lys Asp Arg His Glu Leu Lys 
            500                 505                 510         


Lys Arg Gln Glu Glu Asn Arg Lys Gln Arg Glu Lys Thr Ile Ser Glu 
        515                 520                 525             


Ile Lys Thr Leu Phe Pro Asn Phe Ser Gly Glu Pro Lys Gly Lys Asp 
    530                 535                 540                 


Ile Leu Lys Met Arg Leu Tyr Tyr Gln Gln Asn Ala Lys Cys Leu Tyr 
545                 550                 555                 560 


Ser Gly Lys Pro Leu Glu Leu His Arg Leu Phe Glu Gln Lys Tyr Val 
                565                 570                 575     


Glu Val Asp His Ala Leu Pro Leu Ser Arg Thr Trp Asp Asp Ser Phe 
            580                 585                 590         


Asn Asn Lys Val Leu Val Leu Ala Asn Glu Asn Gln Asn Lys Gly Asn 
        595                 600                 605             


Leu Thr Pro Phe Glu Trp Leu Asp Gly Lys Asn Asn Ser Glu Arg Trp 
    610                 615                 620                 


Arg Thr Phe Lys Ala Leu Val Glu Thr Ser Ala Phe Pro Tyr Ala Lys 
625                 630                 635                 640 


Lys Gln Arg Ile Leu Ser Gln Lys Leu Asp Glu Lys Gly Phe Ile Glu 
                645                 650                 655     


Arg Asn Leu Asn Asp Thr Arg Tyr Val Ala Arg Phe Leu Cys Asn Phe 
            660                 665                 670         


Ile Ala Asp Asn Met His Leu Thr Gly Glu Gly Lys Arg Lys Val Phe 
        675                 680                 685             


Ala Ser Asn Gly Gln Ile Thr Ala Leu Leu Arg Arg Arg Trp Gly Leu 
    690                 695                 700                 


Ala Lys Ser Arg Glu Asp Asn Asp Arg His His Ala Leu Asp Ala Val 
705                 710                 715                 720 


Leu Val Ala Cys Ser Thr Val Ala Met Gln Gln Lys Ile Thr Arg Phe 
                725                 730                 735     


Val Arg Phe Lys Ala Gly Asp Val Phe Thr Gly Glu Arg Ile Asp Arg 
            740                 745                 750         


Glu Thr Gly Glu Ile Ile Pro Leu His Phe Pro Thr Pro Trp Gln Phe 
        755                 760                 765             


Phe Lys Gln Glu Val Glu Ile Arg Ile Phe Ser Asp Asn Pro Lys Leu 
    770                 775                 780                 


Glu Leu Glu Asn Arg Leu Pro Asp Arg Pro Gln Ala Asn His Glu Phe 
785                 790                 795                 800 


Val Gln Pro Leu Phe Val Ser Arg Met Pro Thr Arg Lys Met Thr Gly 
                805                 810                 815     


Gln Gly His Met Glu Thr Val Lys Ser Ala Lys Arg Leu Asn Glu Gly 
            820                 825                 830         


Ile Ser Met Ile Lys Met Pro Leu Thr Lys Leu Lys Leu Lys Asp Leu 
        835                 840                 845             


Glu Leu Met Val Asn Arg Glu Arg Glu Lys Asp Leu Tyr Asp Ala Leu 
    850                 855                 860                 


Lys Thr Arg Leu Glu Ala Phe Asn Asp Asp Pro Ala Lys Ala Phe Ala 
865                 870                 875                 880 


Glu Pro Phe Met Lys Lys Gly Gly Ala Ile Val Lys Ser Val Arg Val 
                885                 890                 895     


Glu Gln Val Gln Lys Ser Gly Val Leu Val Arg Gln Gly Asn Gly Val 
            900                 905                 910         


Ala Asp Asn Ala Ser Met Val Arg Val Asp Val Phe Thr Lys Asp Gly 
        915                 920                 925             


Lys Tyr Phe Leu Val Pro Ile Tyr Thr Trp Gln Val Ala Lys Gly Ile 
    930                 935                 940                 


Leu Pro Asn Lys Ala Val Ile Gln Gly Lys Asp Glu Glu Asp Trp Glu 
945                 950                 955                 960 


Asp Ile Asp Asp Ala Thr Phe Gln Phe Ser Leu His Pro Asn Asp Leu 
                965                 970                 975     


Ile Ser Val Lys Thr Lys Lys Asp Glu Phe Leu Gly Tyr Phe Asn Gly 
            980                 985                 990         


Leu Asn Arg His Thr Gly Gly Ile  Asn Ile Arg Thr His  Asp Leu Glu 
        995                 1000                 1005             


Lys Ser  Lys Gly Lys Gln Gly  Ile Phe Glu Gly Ile  Gly Val Lys 
    1010                 1015                 1020             


Ile Ala  Leu Ser Phe Glu Lys  Tyr Gln Ile Asp Glu  Leu Gly Lys 
    1025                 1030                 1035             


Asn Ile  Arg Leu Cys Lys Pro  Ser Lys Arg Gln Pro  Val Arg 
    1040                 1045                 1050         


<210> 251
<211> 1052
<212> PRT
<213> Haemophilus sputorum


<220>
<223> Haemophilus sputorum HK 2154

<400> 251
Met Lys Asn Thr Ser Leu Asn Tyr Val Leu Gly Leu Asp Leu Gly Ile 
1               5                   10                  15      


Ser Ser Val Gly Trp Ala Val Val Glu Ile Asp Glu Lys Glu Asn Pro 
            20                  25                  30          


Leu Ser Leu Ile Asp Val Gly Val Arg Thr Phe Glu Arg Ala Glu Thr 
        35                  40                  45              


Gln Lys Gly Glu Ser Leu Ala Leu Ala Arg Arg Leu Ala Arg Ser Ala 
    50                  55                  60                  


Arg Arg Leu Thr Gln Arg Arg Val Ala Arg Leu Lys Lys Ala Lys Arg 
65                  70                  75                  80  


Leu Leu Lys Ser Glu Asn Ile Leu Leu Ser Thr Asp Glu Cys Leu Pro 
                85                  90                  95      


His Gln Val Trp Gln Leu Arg Val Glu Gly Leu Glu Arg Lys Leu Glu 
            100                 105                 110         


Arg Gln Glu Trp Ala Ala Val Leu Leu His Leu Ile Lys His Arg Gly 
        115                 120                 125             


Tyr Leu Ser Gln Arg Lys Asn Glu Ser Lys Ser Glu Asn Lys Glu Leu 
    130                 135                 140                 


Gly Ala Leu Leu Ser Gly Val Ala Asn Asn His Lys Leu Leu Gln Gln 
145                 150                 155                 160 


Thr Thr Tyr Arg Thr Pro Ala Glu Leu Ala Val Lys Lys Phe Glu Val 
                165                 170                 175     


Glu Glu Gly His Ile Arg Asn Gln Gln Gly Ser Tyr Thr His Thr Phe 
            180                 185                 190         


Ser Arg Leu Asp Leu Leu Ser Glu Met Glu Leu Leu Phe Ser Arg Gln 
        195                 200                 205             


Gln His Phe Gly Asn Pro Phe Thr Ser Glu Lys Leu Leu Glu Asn Leu 
    210                 215                 220                 


Thr Ala Leu Leu Met Trp Gln Lys Pro Ala Leu Ser Gly Asp Ala Ile 
225                 230                 235                 240 


Leu Lys Met Leu Gly Lys Cys Thr Phe Glu Asn Glu Tyr Lys Ala Ala 
                245                 250                 255     


Lys His Thr Tyr Ser Ala Glu Arg Phe Ile Trp Ile Thr Lys Leu Asn 
            260                 265                 270         


Asn Leu Arg Ile Gln Glu Asn Gly Leu Glu Arg Ala Leu Asn Asp Asn 
        275                 280                 285             


Glu Arg Leu Ala Leu Met Lys Gln Pro Tyr Glu Lys Ala Lys Leu Thr 
    290                 295                 300                 


Tyr Ala Gln Val Arg Ser Ile Leu Asn Leu Ser Asp Glu Ala Ile Phe 
305                 310                 315                 320 


Lys Gly Leu Arg Tyr Ser Gly Glu Asp Lys Lys Thr Ser Glu Thr Lys 
                325                 330                 335     


Thr Val Leu Met Glu Met Lys Ala Tyr His Gln Ile Arg Leu Ala Leu 
            340                 345                 350         


Glu Lys Asn Asp Leu Lys Thr Glu Trp Ala Glu Leu Lys Val Asn Ser 
        355                 360                 365             


Ser Leu Leu Asp Glu Ile Gly Thr Ala Phe Ser Leu Tyr Lys Thr Asp 
    370                 375                 380                 


Glu Asp Ile Ser Thr Cys Leu Ala Gly Lys Leu Ser Gln Pro Val Leu 
385                 390                 395                 400 


Asn Ala Leu Leu Glu Asn Leu Asn Phe Asp Lys Phe Ile Gln Leu Ser 
                405                 410                 415     


Leu Lys Ala Leu His Lys Ile Leu Pro Leu Met Gln Gln Gly Leu Arg 
            420                 425                 430         


Tyr Asp Glu Ala Cys Ala Glu Ile Tyr Gly Asp His Tyr Gly Lys Lys 
        435                 440                 445             


Thr Glu Glu Asn His Leu Leu Leu Pro Gln Ile Pro Ala Asp Glu Ile 
    450                 455                 460                 


Arg Asn Pro Val Val Leu Arg Thr Leu Thr Gln Ala Arg Lys Val Ile 
465                 470                 475                 480 


Asn Gly Val Val Arg Leu Tyr Ser Ser Pro Ala Arg Ile His Ile Glu 
                485                 490                 495     


Thr Gly Arg Glu Val Gly Lys Ser Tyr Gln Asp Arg Arg Glu Leu Glu 
            500                 505                 510         


Lys Arg Gln Glu Glu Asn Arg Lys Gln Arg Glu Lys Ala Ile Ser Glu 
        515                 520                 525             


Ile Lys Thr Leu Phe Pro Asn Phe Ser Gly Glu Pro Lys Ala Lys Asp 
    530                 535                 540                 


Ile Leu Lys Met Arg Leu Tyr Tyr Gln Gln Asn Ala Lys Cys Leu Tyr 
545                 550                 555                 560 


Ser Gly Lys Pro Leu Glu Leu His Arg Leu Leu Glu Gln Gly Tyr Val 
                565                 570                 575     


Glu Ile Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp Ser Phe 
            580                 585                 590         


Asn Asn Lys Val Leu Val Leu Ala Asn Glu Asn Gln Asn Lys Gly Asn 
        595                 600                 605             


Leu Thr Pro Phe Glu Trp Leu Asp Gly Lys Asn Asn Ser Glu Arg Trp 
    610                 615                 620                 


Lys Ala Phe Lys Ala Leu Val Glu Thr Ser Ala Phe Pro Tyr Thr Lys 
625                 630                 635                 640 


Lys Gln Arg Ile Leu Ser Gln Lys Leu Asp Glu Lys Gly Phe Ile Glu 
                645                 650                 655     


Arg Asn Leu Asn Asp Thr Arg Tyr Val Ala Arg Phe Leu Cys Asn Phe 
            660                 665                 670         


Ile Ala Asp Asn Met His Leu Thr Gly Glu Gly Lys Arg Lys Val Phe 
        675                 680                 685             


Ala Ser Asn Gly Gln Ile Thr Ala Leu Leu Arg Gly Arg Trp Gly Leu 
    690                 695                 700                 


Ala Lys Ser Arg Glu Asp Asn Asp Arg His His Ala Leu Asp Ala Val 
705                 710                 715                 720 


Val Val Ala Cys Ser Thr Val Ser Met Gln Gln Lys Ile Thr Arg Phe 
                725                 730                 735     


Val Arg Phe Glu Glu Gly Asn Val Phe Thr Gly Glu Arg Ile Asp Arg 
            740                 745                 750         


Glu Thr Gly Glu Ile Ile Pro Leu His Phe Pro Ala Pro Trp Lys Phe 
        755                 760                 765             


Phe Arg Glu Glu Val Glu Ile Arg Ile Phe Ser Asp Asn Pro Lys Leu 
    770                 775                 780                 


Glu Leu Glu Asn Arg Leu Ile Ala Arg Pro Gln Ala Asn His Glu Phe 
785                 790                 795                 800 


Val Gln Pro Leu Phe Val Ser Arg Met Pro Thr Arg Lys Met Thr Gly 
                805                 810                 815     


Gln Gly His Met Glu Thr Ile Lys Ser Ala Lys Arg Leu Asn Glu Gly 
            820                 825                 830         


Leu Ser Val Ile Lys Met Leu Leu Thr Lys Leu Arg Leu Lys Asp Leu 
        835                 840                 845             


Glu Ser Met Val Asn Arg Glu Arg Glu Lys Glu Leu Tyr Glu Ala Leu 
    850                 855                 860                 


Lys Ala Arg Leu Glu Ala Phe Asn Asp Glu Pro Ala Lys Ala Phe Ala 
865                 870                 875                 880 


Glu Pro Phe Met Lys Lys Gly Gly Ala Ile Val Lys Ser Val Arg Val 
                885                 890                 895     


Glu Gln Val Gln Lys Ser Gly Val Leu Val Arg Asp Gly Asn Gly Val 
            900                 905                 910         


Ala Asp Asn Ala Ser Met Val Arg Val Asp Val Phe Thr Lys Gly Gly 
        915                 920                 925             


Lys Tyr Phe Leu Val Pro Ile Tyr Thr Trp Gln Val Ala Lys Gly Ile 
    930                 935                 940                 


Leu Pro Asn Lys Ala Val Ile Gln Gly Lys Asn Glu Glu Asp Trp Glu 
945                 950                 955                 960 


Val Met Asp Asp Ala Thr Phe Arg Phe Ser Leu His Gln Asn Asp Leu 
                965                 970                 975     


Val Lys Leu Val Thr Lys Lys Lys Thr Ile Phe Gly Tyr Phe Asn Gly 
            980                 985                 990         


Leu Asn Arg Ala Thr Gly Asn Ile  Asp Ile Lys Glu His  Asp Leu Glu 
        995                 1000                 1005             


Lys Ser  Lys Val Lys Asp Gly  Ile His Gln Ser Ile  Gly Ile Lys 
    1010                 1015                 1020             


Leu Ala  Leu Ser Phe Glu Lys  Tyr Gln Val Asp Glu  Leu Gly Lys 
    1025                 1030                 1035             


Asn Ile  Arg Leu Cys Lys Ser  Ser Lys Arg Gln Ala  Val Arg 
    1040                 1045                 1050         


<210> 252
<211> 1338
<212> PRT
<213> Helcococcus kunzii


<220>
<223> Helcococcus kunzii ATCC 51366

<400> 252
Met Gln Asp Tyr Tyr Leu Gly Leu Asp Ile Gly Thr Asn Ser Val Gly 
1               5                   10                  15      


Trp Ala Val Thr Asp Glu Asn Tyr Asn Leu Leu Arg Lys Lys Gly Lys 
            20                  25                  30          


Asp Leu Trp Gly Val Arg Leu Phe Lys Glu Ala Gln Pro Ala Thr Glu 
        35                  40                  45              


Arg Arg Gly His Arg Ser Ser Arg Arg Arg Thr Ile Arg Lys Ser Leu 
    50                  55                  60                  


Arg Lys Gln Leu Leu Arg Glu Leu Phe Glu Glu Glu Ile Asn Ala Ile 
65                  70                  75                  80  


Asp Lys Asp Phe Phe Leu Arg Leu Asp Glu Ser Lys Tyr Trp Leu Glu 
                85                  90                  95      


Asp Lys Lys Ile Glu Gly Lys Tyr Ser Leu Phe Asn Asp Glu Asn Phe 
            100                 105                 110         


Thr Asp Lys Asp Tyr Tyr Glu Lys Phe Pro Thr Ile Phe His Leu Arg 
        115                 120                 125             


Lys Ala Leu Ile Glu Ser Asp Asp Lys Glu Asp Ile Arg Leu Tyr Phe 
    130                 135                 140                 


Leu Ala Ile Asn Gln Met Met Lys Arg Arg Gly His Phe Leu Ile Asp 
145                 150                 155                 160 


Gly Lys Leu Ser Asn Val Glu Asp Ile Thr Pro Phe Lys Glu Cys Ile 
                165                 170                 175     


Gln Asn Leu Ile Asn Glu Glu Leu Asp Thr Glu Ile Glu Thr Glu Phe 
            180                 185                 190         


Tyr Asp Lys Ala Ile Lys Ile Val Ser Asp Tyr Ser Leu Lys Lys Thr 
        195                 200                 205             


Glu Lys Lys Asn Leu Ile Lys Asp Leu Val Lys Glu Thr Asp Ser Ile 
    210                 215                 220                 


Glu Asp Ser Lys Lys Ile Ile Asn Ile Phe Asn Leu Leu Ile Ser Gly 
225                 230                 235                 240 


Lys Ser Lys Val Asn Gly Ile Phe Asp Asp Glu Glu Ile Leu Glu Lys 
                245                 250                 255     


Ile Lys Glu Asp Asn Lys Glu Asp Phe Tyr Leu Thr Ser Glu Lys Tyr 
            260                 265                 270         


Glu Glu Asn Leu Glu Tyr Phe Ser Gln Leu Leu Asp Tyr Arg Phe Glu 
        275                 280                 285             


Leu Ile Ser Ser Leu Lys Ser Ile Tyr Asp Tyr Ile Ile Leu Gln Glu 
    290                 295                 300                 


Val Leu Lys Gly Lys Lys Tyr Leu Ser Tyr Ala Gln Val Glu Arg Tyr 
305                 310                 315                 320 


Lys Asn His Lys Glu Asp Leu Arg Lys Leu Lys Gln Leu Ile Lys Lys 
                325                 330                 335     


Tyr Asp Lys Asn Gly Lys Ile Tyr Tyr Gln Ile Phe Arg Asp Glu Asn 
            340                 345                 350         


Phe Lys Lys Gly Tyr Val Ala Tyr Leu Gly Tyr Tyr Lys Lys Asn Lys 
        355                 360                 365             


Lys Asn Val Pro Val Lys Lys Cys Asp Tyr Asp Thr Phe Ser Lys Asn 
    370                 375                 380                 


Ile Lys Ser Thr Leu Asp Lys Ile Cys Asp Lys Glu Asp Pro Leu Tyr 
385                 390                 395                 400 


Ile Glu Leu Ile Asp Lys Ile Glu Lys Gly Gly Phe Leu Leu Lys Gln 
                405                 410                 415     


Ile Val Ser Thr Asn Ser Val Ile Pro His Gln Val His Glu Leu Glu 
            420                 425                 430         


Leu Asp Lys Ile Leu Glu Asn Leu Glu Lys Asn Tyr Pro Ser Phe Lys 
        435                 440                 445             


Glu Ile Ser Asp Gly Val Ser Lys Ile Asp Lys Ile Lys Met Ile Phe 
    450                 455                 460                 


Asn Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Asn Asp Tyr His Lys 
465                 470                 475                 480 


Asp Lys Val Asn Ser Asn Thr Trp Ile Val Lys Asn Glu Gly Phe Glu 
                485                 490                 495     


Asn Glu Asn Ile Arg Pro Trp Asn Phe Ser Lys Ile Val Asp Glu His 
            500                 505                 510         


Ala Cys Glu Glu Glu Phe Ile Lys Arg Met Ile Asn Glu Cys Ser Tyr 
        515                 520                 525             


Ile Pro Gly Glu Lys Val Leu Pro Lys Ser Ser Leu Leu Tyr Ser Glu 
    530                 535                 540                 


Tyr Met Val Leu Asn Glu Leu Asn Asn Leu Arg Val Asn Gly Asp Lys 
545                 550                 555                 560 


Leu Asn Pro Lys Ile Lys Lys Glu Ile Val Glu Asn Ile Tyr Lys Lys 
                565                 570                 575     


Glu Arg Lys Val Thr Leu Lys Lys Ile Arg Asn Phe Leu Ile Ile Asn 
            580                 585                 590         


Asn Tyr Val Asp Ser Lys Val Glu Phe Ser Gly Leu Ser Asp Gly Ile 
        595                 600                 605             


Lys Ala Asn Met Ser Ser Tyr Ile Asp Phe Ala Glu Ile Leu Asp Asp 
    610                 615                 620                 


Asn Phe Asp Asn Asn Met Val Glu Asp Leu Ile Glu Gln Ile Thr Ile 
625                 630                 635                 640 


His Val Gly Asn Val Lys Leu Leu Thr Glu Lys Ile Ser Asn Lys Tyr 
                645                 650                 655     


Pro Asn Leu Glu Lys Lys Gln Ile Asn Lys Ile Val Asn Leu Lys Phe 
            660                 665                 670         


Lys Asp Trp Ala Arg Phe Ser Arg Lys Leu Leu Val Gly Ile Glu Gly 
        675                 680                 685             


Thr Glu Lys Glu Thr Gly Glu Ile Asn Thr Ile Ile Gly Phe Leu Arg 
    690                 695                 700                 


Glu Thr Asn Glu Asn Phe Met Glu Leu Met Ser Asn Arg Tyr Thr Phe 
705                 710                 715                 720 


Ser Glu Glu Ile Ser Glu Ile Lys Lys Lys Tyr Ile Pro Asn Lys Leu 
                725                 730                 735     


Ser Lys Gln Ile Val Asp Asp Leu Tyr Val Ser Pro Ala Val Lys Lys 
            740                 745                 750         


Met Ile Trp Gln Val Leu Asn Ile Asn Asp Glu Leu Ile Lys Val Leu 
        755                 760                 765             


Gly Lys Gln Pro Lys Lys Ile Phe Ile Glu Met Ala Arg Gly Lys Glu 
    770                 775                 780                 


Glu Lys Pro Glu Val Lys Asp Ser Arg Lys Asn Lys Leu Ile Glu Leu 
785                 790                 795                 800 


Tyr Lys Asn Leu Gly Lys Glu Gly Lys Glu Trp Leu Asn Arg Ile Glu 
                805                 810                 815     


Asp Lys Thr Glu Ala Asp Phe Arg Asn Arg Ala Leu Tyr Leu Tyr Tyr 
            820                 825                 830         


Thr Gln Met Gly Arg Cys Met Tyr Thr Gly Glu Ile Ile Asp Ile Glu 
        835                 840                 845             


Arg Leu Tyr Asp Lys Glu Leu Tyr Asp Leu Asp His Ile Ile Pro Arg 
    850                 855                 860                 


Lys Met Lys Lys Asp Asp Ser Ile His Lys Asn Leu Val Leu Val Thr 
865                 870                 875                 880 


Arg Asn Ser Asn Gln Tyr Glu Lys Lys Asp Asn Tyr Pro Val Pro Glu 
                885                 890                 895     


Val Ile Lys Ser Arg Glu Asn Val Arg His Leu Trp Tyr Ala Leu Lys 
            900                 905                 910         


Lys Lys Gly Leu Ile Thr Glu Glu Lys Tyr Asn Arg Leu Thr Arg Ile 
        915                 920                 925             


Asn Pro Leu Ser Asp Lys Glu Leu Ser Glu Phe Ile Glu Arg Gln Leu 
    930                 935                 940                 


Val Glu Thr Arg Gln Thr Thr Lys Val Val Lys Asp Leu Phe Glu Asn 
945                 950                 955                 960 


Tyr Tyr Thr Asp Ser Lys Ile Val Thr Val Lys Ala Gly Leu Val Ser 
                965                 970                 975     


Glu Leu Arg Arg Asp Phe Glu Val Leu Lys Cys Arg Glu Ile Asn Asp 
            980                 985                 990         


Leu Asn His Ala His Asp Ala Phe  Leu Asn Ile Ile Val  Gly Asp Val 
        995                 1000                 1005             


Trp Ser  Lys Lys Phe Thr Ser  Asn Pro Tyr Asn Phe  Val Lys Lys 
    1010                 1015                 1020             


Asn Arg  Glu Lys Tyr Thr Leu  Asn Asn Ile Phe Thr  Lys Asn Gln 
    1025                 1030                 1035             


Lys Asp  Leu Arg Gly Asn Glu  Ile Trp Asn Cys Ala  Glu Gly Lys 
    1040                 1045                 1050             


Lys Arg  Ile Ile Lys Thr Leu  Asn Lys Pro Ser Val  Leu Phe Ser 
    1055                 1060                 1065             


Val Glu  Asn Phe Glu Gln Thr  Gly Gln Leu Phe Asp  Gln Asn Ile 
    1070                 1075                 1080             


Ile Gly  Lys Gln Asp Tyr Lys  Glu Lys Thr Ser Tyr  Val Pro Ile 
    1085                 1090                 1095             


Lys Gly  Asp Glu Arg Leu Gln  Asp Ile Ser Lys Tyr  Gly Gly Tyr 
    1100                 1105                 1110             


Arg Gly  Ile Ser Gly Ala Tyr  Phe Phe Ile Val Glu  His Thr Glu 
    1115                 1120                 1125             


Lys Asn  Lys Arg Val Lys Thr  Ile Glu Ser Leu Pro  Ile Tyr Met 
    1130                 1135                 1140             


Lys Ser  Tyr Val Glu Glu Asn  Gly Leu Leu Asp Phe  Cys Thr Asn 
    1145                 1150                 1155             


Glu Met  Lys Leu Val Asp Pro  Lys Ile Ile Val Lys  Lys Leu Asn 
    1160                 1165                 1170             


Tyr Lys  Ser Glu Ile Ile Val  Asp Gly Phe Lys Tyr  Leu Ile Ser 
    1175                 1180                 1185             


Gly Lys  Thr Glu Asn Arg Leu  Ser Leu Glu Thr Asn  Glu Tyr Leu 
    1190                 1195                 1200             


Tyr Trp  Asn His Thr Gln Thr  Thr Asp Ile Lys Lys  Ile Leu Asn 
    1205                 1210                 1215             


Ile Asn  Glu Lys Ile Glu Leu  Glu Lys Tyr Asn Gly  Asp Ile Glu 
    1220                 1225                 1230             


Ser Glu  Arg Glu Asn Ile Ile  Lys Tyr Ile Gln Ile  Ile Leu Glu 
    1235                 1240                 1245             


Lys Phe  Lys Leu Lys Pro Phe  Ile Lys Arg Arg Asn  Leu Pro Asn 
    1250                 1255                 1260             


Ile Glu  Ile Asn Phe Ala Asp  Tyr Glu Thr Glu Lys  Leu Leu Gln 
    1265                 1270                 1275             


Leu Leu  Val Asn Leu Ile Pro  Leu Thr Thr Lys Tyr  Val Ser Pro 
    1280                 1285                 1290             


Val Asp  Leu Thr Val Ile Ser  Gly Ser Lys Tyr Ala  Gly Lys Val 
    1295                 1300                 1305             


Leu Ile  Pro Lys Lys Ile Ser  Asn Leu Asn Glu Val  Ile Phe Ile 
    1310                 1315                 1320             


Ser Lys  Ser Ile Thr Gly Ile  Tyr Glu Ser Arg Arg  Arg Ile Ile 
    1325                 1330                 1335             


<210> 253
<211> 1007
<212> PRT
<213> Helicobacter canadensis


<220>
<223> Helicobacter canadensis MIT 98-5491

<400> 253
Met Lys Val Leu Gly Phe Asp Ile Gly Ile Asn Ser Ile Gly Trp Ala 
1               5                   10                  15      


Phe Val Glu Asn Asn Glu Leu Lys Asp Cys Gly Val Arg Leu Phe Thr 
            20                  25                  30          


Lys Ala Glu Asn Pro Lys Thr Lys Glu Ser Leu Ala Leu Pro Arg Arg 
        35                  40                  45              


Asn Ala Arg Ser Ser Arg Val Arg Leu Arg Arg Arg Arg Ser Arg Leu 
    50                  55                  60                  


Leu Ser Leu Lys His Ile Ile Ser Lys Glu Phe Gly Leu His Tyr Glu 
65                  70                  75                  80  


Asp Tyr Ile Ala Leu Asp Gly Asn Leu Pro Lys Ala Tyr Thr Gly Lys 
                85                  90                  95      


Ile Glu Ser Ile Tyr Lys Leu Arg Tyr Glu Ala Leu Ser Gln Ala Ile 
            100                 105                 110         


Ser Lys Glu Asp Leu Ala Arg Val Ile Leu His Ile Ala Lys His Arg 
        115                 120                 125             


Gly Tyr Met Asn Lys Asn Gln Lys Thr Ser Gln Asp Ser Glu Lys Gly 
    130                 135                 140                 


Ala Ile Leu Ser Ala Ile Lys Glu Asn Ser Asn Lys Ile Lys His Tyr 
145                 150                 155                 160 


Gln Thr Ala Gly Glu Tyr Phe Tyr Lys Glu Leu Phe Glu Asn Leu Arg 
                165                 170                 175     


Asp Gly Thr Lys Glu Phe Lys Asn Ile Arg Asn Lys Ala Met Lys Asn 
            180                 185                 190         


Glu Lys Thr Gly Asn Met Glu Ser Thr Tyr Tyr Asn Thr Ile Leu Ala 
        195                 200                 205             


Ser Asp Leu Glu Lys Glu Leu Lys Leu Ile Leu Glu Lys Gln Gln Ala 
    210                 215                 220                 


Tyr His Asn Tyr Ser Asp Thr Phe Ile Lys Glu Val Leu Glu Ile Ala 
225                 230                 235                 240 


Phe Tyr Gln Arg Pro Leu Lys Asp Phe Ser His Leu Val Gly Ser Cys 
                245                 250                 255     


Thr Phe Tyr Glu Asn Glu Lys Arg Ala Cys Lys Asn Ser Tyr Ser Ala 
            260                 265                 270         


Trp Glu Phe Ile Ala Leu Gly Lys Ile Ile Asn Thr Leu Glu Ser Ile 
        275                 280                 285             


Lys Lys Asp Thr Gly Glu Ile Phe Ser Asn Glu Ile Ile Thr Gln Ile 
    290                 295                 300                 


Leu Lys Glu Val Leu Asp Lys Gly Ser Leu Ser Tyr Thr Lys Leu Arg 
305                 310                 315                 320 


Lys Met Ile Asn Leu Asp Glu Lys Val Lys Phe Lys Gly Leu Lys Tyr 
                325                 330                 335     


Asp Lys Glu Gly Val Glu Lys Thr Asn Leu Ile Glu Phe Lys Lys Leu 
            340                 345                 350         


Lys Glu Phe Lys Lys Ala Leu Gly Glu His Asn Leu Glu Arg Lys Thr 
        355                 360                 365             


Leu Asp Glu Ile Ala Thr His Ile Thr Leu Thr Lys Asp Glu Asn Gln 
    370                 375                 380                 


Leu Lys Lys Gln Leu Glu Gln Tyr Ala Leu Ser Gln Asn Gln Ile Asp 
385                 390                 395                 400 


Ala Leu Ala Glu Leu Asp Phe Asn Asp His Ile Asn Leu Ser Phe Lys 
                405                 410                 415     


Ala Leu Tyr Glu Ile Leu Pro Leu Met Glu Lys Gly Lys Arg Tyr Asp 
            420                 425                 430         


Glu Ala Cys Asn Glu Leu Gly Leu Lys Ala Lys Thr Ser Asn Gln Lys 
        435                 440                 445             


Ser Glu Phe Leu Pro Ala Phe Cys Asp Ser Ile Phe Ala Gln Glu Leu 
    450                 455                 460                 


Thr Asn Pro Ile Val Asn Arg Ala Ile Ser Glu Tyr Arg Lys Val Leu 
465                 470                 475                 480 


Asn Arg Leu Leu Lys Lys Tyr Gly Lys Met His Lys Ile His Ile Glu 
                485                 490                 495     


Leu Ala Arg Asp Ala Gly Leu Ser Lys Glu Ala Arg Asn Lys Ile Glu 
            500                 505                 510         


Lys Glu Gln Lys Glu Asn Lys Asp Ile Asn Asp Lys Ala Glu Lys Thr 
        515                 520                 525             


Cys Lys Glu Phe Gly Leu Lys Pro Asn Ala Lys Asn Ile Leu Lys Ile 
    530                 535                 540                 


Lys Leu Trp Arg Glu Gln Gly Glu Ile Cys Ala Tyr Ser Gly Lys Lys 
545                 550                 555                 560 


Ile Thr Ile Asp Asp Leu Lys Glu Asp Lys Ala Leu Glu Val Asp His 
                565                 570                 575     


Ile Tyr Pro Tyr Ser Arg Ser Tyr Asp Asp Ser Tyr Asn Asn Lys Val 
            580                 585                 590         


Leu Val Phe Ile Lys Glu Asn Gln Leu Lys Leu Asn Gln Thr Pro Tyr 
        595                 600                 605             


Glu Ala Phe Gly Ser Asn Gln Glu Lys Trp Ser Lys Ile Gln Val Leu 
    610                 615                 620                 


Ala Gln Lys Leu Pro Tyr Lys Lys Lys Asn Arg Ile Leu Asp Glu Asn 
625                 630                 635                 640 


Phe Lys Asn Lys Asp Gln Ile Glu Phe Ile Ser Arg Asn Leu Asn Asp 
                645                 650                 655     


Thr Arg Tyr Ala Thr Ser Leu Ile Ala Lys Tyr Thr Lys Glu Tyr Leu 
            660                 665                 670         


Glu Phe Leu Pro Leu Ser Asp Asp Glu Asp Ile Ser Leu Lys Ser Gly 
        675                 680                 685             


Glu Lys Gly Ser Lys Thr His Val Gln Thr Met Asn Gly Met Leu Thr 
    690                 695                 700                 


Ser Val Leu Arg His Ala Trp Gly Phe Ser Gln Lys Asp Arg Asn Asn 
705                 710                 715                 720 


His Leu His His Ala Leu Asp Ala Ile Ile Ile Ala Tyr Ser Thr Asn 
                725                 730                 735     


Ser Ile Ile Lys Ala Phe Ser Asp Phe Lys Lys Asn Gln Glu Ile Leu 
            740                 745                 750         


Lys Ala Lys Leu Tyr Ala Lys Lys Leu Thr Ser Glu Glu Tyr Lys Asn 
        755                 760                 765             


Gln Ser Lys Phe Thr Gly Phe Glu Lys Tyr Arg Ser Lys Ile Leu Glu 
    770                 775                 780                 


Lys Leu Asp Ser Ile Phe Val Ser Lys Pro Pro Asn Lys Asn Thr Lys 
785                 790                 795                 800 


Gly Ala Leu His Glu Gln Thr Phe Tyr Ser Tyr Gln Asp Ile Leu Glu 
                805                 810                 815     


Glu Tyr Lys Thr Gln Glu Gly Leu Lys Arg Ala Leu Glu Cys Gly Lys 
            820                 825                 830         


Val Arg Lys Ile Gly Thr Lys Tyr Val Val Asn Asp Arg Met Val Arg 
        835                 840                 845             


Leu Asp Ile Phe Lys Lys Asp Asn Lys Phe Tyr Gly Ile Pro Ile Tyr 
    850                 855                 860                 


Thr Met Asp Phe Ala Leu Gly Val Leu Pro Asn Lys Val Val Thr Ile 
865                 870                 875                 880 


Gly Thr Asp Lys Asp Lys Ile Lys Lys Glu Trp Lys Thr Ile Asp Glu 
                885                 890                 895     


Thr Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Gly Asp Leu Val Leu Ile 
            900                 905                 910         


Gln Lys Lys Glu Met Gln Glu Ser Glu Phe Ala Tyr Tyr Asn Gly Phe 
        915                 920                 925             


Asp Ile Ser Ser Ala Ser Ile Ser Leu Glu Lys His Asp Asn Lys Phe 
    930                 935                 940                 


Glu Asn Leu Thr Glu Asn Gln Lys Leu Leu Phe Pro Lys Ala Lys Glu 
945                 950                 955                 960 


Gly Asp Val Glu Val Arg Gly Ile Gly Ile Gln Gly Leu Lys Val Phe 
                965                 970                 975     


Lys Lys Tyr Met Val Thr Pro Leu Gly Glu Ile Gln Glu Thr Arg Thr 
            980                 985                 990         


Glu Ala Arg Gln Asn Ile Gln Pro  Arg Lys Lys His Gly  Leu Arg 
        995                 1000                 1005         


<210> 254
<211> 1023
<212> PRT
<213> Helicobacter cinaedi


<220>
<223> Helicobacter cinaedi CCUG 18818 = ATCC BAA-847

<400> 254
Met Lys Ile Tyr Ser Phe Asp Ile Gly Val Ala Ser Ile Gly Trp Ala 
1               5                   10                  15      


Phe Ile Glu Asn Glu Val Leu Gln Asp Cys Gly Ile Arg Ile Phe Thr 
            20                  25                  30          


Lys Ala Glu Asn Pro Lys Asn Gly Ala Ser Leu Ala Leu Pro Arg Arg 
        35                  40                  45              


Glu Ala Arg Gly Val Arg Lys Arg Leu Ala Arg Arg Arg Gly Arg Leu 
    50                  55                  60                  


Asn Thr Ile Lys Gln Leu Leu Cys Lys Glu Phe Gly Leu Gln Leu Glu 
65                  70                  75                  80  


Asp Tyr Leu Ser Asn Asp Gly Glu Leu Pro Lys Ala Tyr Thr Ala Ser 
                85                  90                  95      


Lys Ala Asn Pro Leu Lys Ser Pro Tyr Glu Leu Arg Thr Leu Ala Leu 
            100                 105                 110         


Ser Gln Lys Leu Asp Ser Lys Asp Leu Val Arg Val Ile Leu His Ile 
        115                 120                 125             


Ala Lys His Arg Gly Tyr Gly Asn Lys His Ala Lys Asp Ser Lys Asp 
    130                 135                 140                 


Thr Glu Ser Gly Lys Val Lys Lys Ala Ile Glu Phe Asn Arg Lys Thr 
145                 150                 155                 160 


Leu Ala Glu Lys Gly Tyr Arg Ser Val Gly Glu Tyr Leu Tyr Arg Glu 
                165                 170                 175     


Phe Phe Gln Gln Ser Arg Ile Ser Gln Asn Asn Gly Ala Thr Glu Phe 
            180                 185                 190         


Ile Asn Val Arg Asn Lys Ala Gly Asn Tyr Glu His Cys Val Ala Gln 
        195                 200                 205             


Asp Met Leu Lys Glu Glu Leu Glu Ser Ile Leu Asn Ala Gln Arg Gln 
    210                 215                 220                 


Phe Gly Phe Ser Leu Lys Gln Asp Phe Glu Ser Lys Leu Leu Thr Lys 
225                 230                 235                 240 


Ile Phe Glu Gln Arg Pro Leu Lys Ser Phe Ala Asp Lys Val Gly Asn 
                245                 250                 255     


Cys Cys Phe Ile Ala Gly Glu Lys Arg Ala Pro Lys Asp Ser Pro Ser 
            260                 265                 270         


Ala Ile Glu Phe Ile Ala Leu Ser Arg Thr Ile Asn Thr Leu Ile Asn 
        275                 280                 285             


Leu Ser Lys Glu Ser Gly Glu Ile Tyr Asn Arg Ala Ile Ile Leu Gln 
    290                 295                 300                 


Ile Val Glu Ser Thr Leu Lys Lys Gly Glu Ile Ser Tyr Lys Glu Leu 
305                 310                 315                 320 


Arg Glu Ile Ile Arg Leu Asp Glu Arg Leu Arg Phe Lys Asp Pro Arg 
                325                 330                 335     


Leu Asp Tyr Ser Arg Glu Ile Lys Glu Ala Glu Lys Val Lys Phe Leu 
            340                 345                 350         


Glu Phe Lys Gln Leu Lys Gly Phe Lys Lys Ala Leu Gly Glu Ser Phe 
        355                 360                 365             


Thr Thr Leu Ala Ile Ser Gln Leu Asp Glu Ile Ala Glu His Ile Ala 
    370                 375                 380                 


Leu Ile Lys Asp Arg Val Lys Leu Asn Glu Lys Leu Glu Ser Tyr Ala 
385                 390                 395                 400 


Leu Thr Lys Glu Gln Arg Glu Ala Leu Ser Asn Leu Ser Phe Ser Ala 
                405                 410                 415     


His Ile Asn Leu Ser Leu Gln Ala Leu Lys Gln Ile Leu Pro Phe Met 
            420                 425                 430         


Arg Gly Asp Asn Gly Glu Gln Cys Leu Asp Tyr Asp Glu Ser Val Glu 
        435                 440                 445             


Lys Ala Gly Leu Lys Ala Leu Ser Lys Asp Thr Leu Lys Gly Gln Met 
    450                 455                 460                 


Leu Pro Pro Leu Asn Glu Phe Glu Pro Tyr Leu Ser Asn Pro Val Val 
465                 470                 475                 480 


Ala Arg Ala Leu Ala Glu Tyr Arg Lys Val Leu Asn Val Leu Leu Lys 
                485                 490                 495     


Gln Tyr Gly Ser Pro His Lys Ile His Ile Glu Tyr Ala Arg Glu Ala 
            500                 505                 510         


Lys Leu Ser Ser Thr Glu Arg Gln Lys Tyr Glu Lys Glu Gln Lys Asp 
        515                 520                 525             


Asn Tyr Ala Ala Asn Gln Ala Ala His Lys Lys Cys Gln Glu Leu Gly 
    530                 535                 540                 


Leu Glu Pro Ser Ser Thr Asn Leu Leu Lys Leu Lys Leu Trp Gln Glu 
545                 550                 555                 560 


Gln Gly Gly Leu Cys Leu Tyr Ser Gly Ala Lys Ile Thr Ile Ser Tyr 
                565                 570                 575     


Leu Gln Asp Pro Thr Ala Leu Gln Val Asp His Ile Tyr Pro Tyr Ser 
            580                 585                 590         


Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Cys Leu Val Leu Thr Lys 
        595                 600                 605             


Ala Asn Gln Glu Lys Gly Asn Arg Thr Pro Phe Glu Ala Phe Gly Thr 
    610                 615                 620                 


Asp Ser Ala Lys Trp Gly Val Ile Thr Thr Leu Ala Gln Lys Leu Pro 
625                 630                 635                 640 


His Lys Lys Arg Arg Arg Ile Leu Asn Thr Ala Phe Asn Asp Lys Glu 
                645                 650                 655     


Ala Gly Phe Lys Leu Arg Asn Leu Asn Asp Thr Ser Tyr Ile Ala Arg 
            660                 665                 670         


Leu Val Ala Asp Tyr Thr Glu Thr Tyr Leu Glu Phe Leu Pro Leu Val 
        675                 680                 685             


Glu Ser Glu Asn Thr Thr Leu Ser Lys Gly Gln Lys Gly Ser Lys Lys 
    690                 695                 700                 


His Ile Ala Ile Val Asn Gly Val Leu Thr Ser Thr Met Arg Tyr Tyr 
705                 710                 715                 720 


Leu Gly Phe Ala Ser Lys Asp Arg Asp Asn His Leu His His Ala Leu 
                725                 730                 735     


Asp Ala Val Ile Ile Gly Phe Met Asn Asp Ser Val Ile Lys Ala Phe 
            740                 745                 750         


Ser Asp Phe Lys Lys Thr Gln Glu Thr Ser Lys Ala Ala Tyr Tyr Ala 
        755                 760                 765             


His Thr Leu Ser Lys Gln Glu Tyr Lys Lys Gln Arg Ala Phe Ile Gln 
    770                 775                 780                 


Leu Pro Ser Gly Glu Asn Phe Arg Val Ser Val Leu Glu Lys Val Glu 
785                 790                 795                 800 


Ser Val Phe Val Ser Lys Pro Pro Arg Lys Arg Val Arg Gly Ala Leu 
                805                 810                 815     


His Glu Ala Thr Phe Tyr Ser Pro Asn Asp Pro Lys Leu Leu Lys Asn 
            820                 825                 830         


Tyr Gly Gly Thr Lys Gly Val Glu Arg Ala Leu Ala Leu Gly Lys Met 
        835                 840                 845             


Arg Lys Val Gly Ala Lys Ile Val Ser Asn Gly Ala Met Val Arg Val 
    850                 855                 860                 


Asp Ile Phe Arg His Lys Ser Ser Gly Lys Phe Tyr Gly Val Pro Val 
865                 870                 875                 880 


Tyr Thr Met Asp Phe Ala Leu Gly Ile Leu Pro Asn Lys Ala Val Val 
                885                 890                 895     


Val Gly Lys Asp Gln Asn Gly Val Ile Lys Asp Trp Leu Glu Met Asp 
            900                 905                 910         


Ser Ser Tyr Glu Phe Ile Phe Ser Leu Tyr Lys Asp Asp Val Ile Leu 
        915                 920                 925             


Val Gln Lys Lys Glu Met Gln Arg Pro Glu Leu Cys Tyr Phe Val Ser 
    930                 935                 940                 


Phe Asp Thr Ser Gly Ala Ser Ile Lys Val Ala Lys His Asp Asn Asn 
945                 950                 955                 960 


Phe Ser Thr Leu Thr Glu Asn Gln Lys Leu Leu Phe Ser Asn Ala Thr 
                965                 970                 975     


Lys Glu Glu Val Val Gly Lys Ser Ile Gly Ile Gln Asn Leu Lys Val 
            980                 985                 990         


Phe Glu Lys Trp Gln Val Ser Val  Leu Gly Glu Val Lys  Arg Thr Gln 
        995                 1000                 1005             


Ser Tyr  Pro Arg Glu Asn Ile  Ser Leu Ala Ser Lys  Ala Lys Lys 
    1010                 1015                 1020             


<210> 255
<211> 1023
<212> PRT
<213> Helicobacter cinaedi


<220>
<223> Helicobacter cinaedi CCUG 18818

<400> 255
Met Lys Ile Tyr Ser Phe Asp Ile Gly Val Ala Ser Ile Gly Trp Ala 
1               5                   10                  15      


Phe Ile Glu Asn Glu Val Leu Gln Asp Cys Gly Ile Arg Ile Phe Thr 
            20                  25                  30          


Lys Ala Glu Asn Pro Lys Asn Gly Ala Ser Leu Ala Leu Pro Arg Arg 
        35                  40                  45              


Glu Ala Arg Gly Val Arg Lys Arg Leu Ala Arg Arg Arg Gly Arg Leu 
    50                  55                  60                  


Asn Thr Ile Lys Gln Leu Leu Cys Lys Glu Phe Gly Leu Gln Leu Glu 
65                  70                  75                  80  


Asp Tyr Leu Ser Asn Asp Gly Glu Leu Pro Lys Ala Tyr Thr Ala Ser 
                85                  90                  95      


Lys Ala Asn Pro Leu Lys Ser Pro Tyr Glu Leu Arg Thr Leu Ala Leu 
            100                 105                 110         


Ser Gln Lys Leu Asp Ser Lys Asp Leu Val Arg Val Ile Leu His Ile 
        115                 120                 125             


Ala Lys His Arg Gly Tyr Gly Asn Lys His Ala Lys Asp Ser Lys Asp 
    130                 135                 140                 


Thr Glu Ser Gly Lys Val Lys Lys Ala Ile Glu Phe Asn Arg Lys Thr 
145                 150                 155                 160 


Leu Ala Glu Lys Gly Tyr Arg Ser Val Gly Glu Tyr Leu Tyr Arg Glu 
                165                 170                 175     


Phe Phe Gln Gln Ser Arg Ile Ser Gln Asn Asn Gly Ala Thr Glu Phe 
            180                 185                 190         


Ile Asn Val Arg Asn Lys Ala Gly Asn Tyr Glu His Cys Val Ala Gln 
        195                 200                 205             


Asp Met Leu Lys Glu Glu Leu Glu Ser Ile Leu Asn Ala Gln Arg Gln 
    210                 215                 220                 


Phe Gly Phe Ser Leu Lys Gln Asp Phe Glu Asn Lys Leu Leu Thr Lys 
225                 230                 235                 240 


Ile Phe Glu Gln Arg Pro Leu Lys Ser Phe Ala Asp Lys Val Gly Asn 
                245                 250                 255     


Cys Cys Phe Ile Ala Gly Glu Lys Arg Ala Pro Lys Asp Ser Pro Ser 
            260                 265                 270         


Ala Ile Glu Phe Ile Ala Leu Ser Arg Thr Ile Asn Thr Leu Ile Asn 
        275                 280                 285             


Leu Ser Lys Glu Ser Gly Glu Ile Tyr Asn Arg Ala Ile Ile Leu Gln 
    290                 295                 300                 


Ile Val Glu Ser Thr Leu Lys Lys Gly Glu Ile Ser Tyr Lys Glu Leu 
305                 310                 315                 320 


Arg Glu Ile Ile Arg Leu Asp Glu Arg Leu Arg Phe Lys Asp Pro Arg 
                325                 330                 335     


Leu Asp Tyr Ser Arg Glu Ile Lys Glu Ala Glu Lys Val Lys Phe Leu 
            340                 345                 350         


Glu Phe Lys Gln Leu Lys Gly Phe Lys Lys Ala Leu Gly Glu Ser Phe 
        355                 360                 365             


Thr Thr Leu Ala Ile Ser Gln Leu Asp Glu Ile Ala Glu His Ile Ala 
    370                 375                 380                 


Leu Ile Lys Asp Arg Val Lys Leu Asn Glu Lys Leu Glu Ser Tyr Ala 
385                 390                 395                 400 


Leu Thr Lys Glu Gln Arg Glu Ala Leu Ser Asn Leu Ser Phe Ser Ala 
                405                 410                 415     


His Ile Asn Leu Ser Leu Gln Ala Leu Lys Gln Ile Leu Pro Phe Met 
            420                 425                 430         


Arg Gly Asp Asn Gly Glu Gln Cys Leu Asp Tyr Asp Glu Ser Val Glu 
        435                 440                 445             


Lys Ala Gly Leu Lys Ala Leu Ser Lys Asp Thr Leu Lys Gly Gln Met 
    450                 455                 460                 


Leu Pro Pro Leu Asn Glu Phe Glu Pro Tyr Leu Ser Asn Pro Val Val 
465                 470                 475                 480 


Ala Arg Ala Leu Ala Glu Tyr Arg Lys Val Leu Asn Val Leu Leu Lys 
                485                 490                 495     


Gln Tyr Gly Ser Pro His Lys Ile His Ile Glu Tyr Ala Arg Glu Ala 
            500                 505                 510         


Lys Leu Ser Ser Thr Glu Arg Gln Lys Tyr Glu Lys Glu Gln Lys Asp 
        515                 520                 525             


Asn Tyr Ala Ala Asn Gln Ala Ala His Lys Lys Cys Gln Glu Leu Gly 
    530                 535                 540                 


Leu Glu Pro Ser Ser Thr Asn Leu Leu Lys Leu Lys Leu Trp Gln Glu 
545                 550                 555                 560 


Gln Gly Gly Leu Cys Leu Tyr Ser Gly Ala Lys Ile Thr Ile Ser Tyr 
                565                 570                 575     


Leu Gln Asp Pro Thr Ala Leu Gln Val Asp His Ile Tyr Pro Tyr Ser 
            580                 585                 590         


Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Cys Leu Val Leu Thr Lys 
        595                 600                 605             


Ala Asn Gln Glu Lys Gly Asn Arg Thr Pro Phe Glu Ala Phe Gly Thr 
    610                 615                 620                 


Asp Ser Ala Lys Trp Gly Val Ile Thr Thr Leu Ala Gln Lys Leu Pro 
625                 630                 635                 640 


His Lys Lys Arg Arg Arg Ile Leu Asn Thr Ala Phe Asn Asp Lys Glu 
                645                 650                 655     


Ala Gly Phe Lys Leu Arg Asn Leu Asn Asp Thr Ser Tyr Ile Ala Arg 
            660                 665                 670         


Leu Val Ala Asp Tyr Thr Glu Thr Tyr Leu Glu Phe Leu Pro Leu Val 
        675                 680                 685             


Glu Ser Glu Asn Thr Thr Leu Ser Lys Gly Gln Lys Gly Ser Lys Lys 
    690                 695                 700                 


His Ile Ala Ile Val Asn Gly Val Leu Thr Ser Thr Met Arg Tyr Tyr 
705                 710                 715                 720 


Leu Gly Phe Ala Ser Lys Asp Arg Asp Asn His Leu His His Ala Leu 
                725                 730                 735     


Asp Ala Val Ile Ile Gly Phe Met Asn Asp Ser Val Ile Lys Ala Phe 
            740                 745                 750         


Ser Asp Phe Lys Lys Thr Gln Glu Thr Ser Lys Ala Ala Tyr Tyr Ala 
        755                 760                 765             


His Thr Leu Ser Lys Gln Glu Tyr Lys Lys Gln Arg Ala Phe Ile Gln 
    770                 775                 780                 


Leu Pro Ser Gly Glu Asn Phe Arg Val Ser Val Leu Glu Lys Val Glu 
785                 790                 795                 800 


Ser Val Phe Val Ser Lys Pro Pro Arg Lys Arg Val Arg Gly Ala Leu 
                805                 810                 815     


His Glu Ala Thr Phe Tyr Ser Pro Asn Asp Pro Lys Leu Leu Lys Asn 
            820                 825                 830         


Tyr Gly Gly Thr Lys Gly Val Glu Arg Ala Leu Ala Leu Gly Lys Met 
        835                 840                 845             


Arg Lys Val Gly Ala Lys Ile Val Ser Asn Gly Ala Met Val Arg Val 
    850                 855                 860                 


Asp Ile Phe Arg His Lys Ser Ser Gly Lys Phe Tyr Gly Val Pro Val 
865                 870                 875                 880 


Tyr Thr Met Asp Phe Ala Leu Gly Ile Leu Pro Asn Lys Ala Val Val 
                885                 890                 895     


Val Gly Lys Asp Gln Asn Gly Val Ile Lys Asp Trp Leu Glu Met Asp 
            900                 905                 910         


Ser Ser Tyr Glu Phe Ile Phe Ser Leu Tyr Lys Asp Asp Val Ile Leu 
        915                 920                 925             


Val Gln Lys Lys Glu Met Gln Arg Pro Glu Leu Cys Tyr Phe Val Ser 
    930                 935                 940                 


Phe Asp Thr Ser Gly Ala Ser Ile Lys Val Ala Lys His Asp Asn Asn 
945                 950                 955                 960 


Phe Ser Thr Leu Thr Glu Asn Gln Lys Leu Leu Phe Ser Asn Ala Thr 
                965                 970                 975     


Lys Glu Glu Val Val Gly Lys Ser Ile Gly Ile Gln Asn Leu Lys Val 
            980                 985                 990         


Phe Glu Lys Trp Gln Val Ser Val  Leu Gly Glu Val Lys  Arg Thr Gln 
        995                 1000                 1005             


Ser Tyr  Pro Arg Glu Asn Ile  Ser Leu Ala Ser Lys  Ala Lys Lys 
    1010                 1015                 1020             


<210> 256
<211> 1023
<212> PRT
<213> Helicobacter cinaedi

<400> 256
Met Lys Ile Tyr Ser Phe Asp Ile Gly Val Ala Ser Ile Gly Trp Ala 
1               5                   10                  15      


Phe Ile Glu Asn Glu Val Leu Gln Asp Cys Gly Ile Arg Ile Phe Thr 
            20                  25                  30          


Lys Ala Glu Asn Pro Lys Asn Gly Ala Ser Leu Ala Leu Pro Arg Arg 
        35                  40                  45              


Glu Ala Arg Gly Val Arg Lys Arg Leu Ala Arg Arg Arg Gly Arg Leu 
    50                  55                  60                  


Asn Thr Ile Lys Gln Leu Leu Cys Lys Glu Phe Gly Leu Gln Leu Glu 
65                  70                  75                  80  


Asp Tyr Leu Ser Asn Asp Gly Glu Leu Pro Lys Ala Tyr Thr Ala Ser 
                85                  90                  95      


Lys Ala Asn Pro Leu Lys Ser Pro Tyr Glu Leu Arg Thr Leu Ala Leu 
            100                 105                 110         


Ser Gln Lys Leu Asp Ser Lys Asp Leu Val Arg Val Ile Leu His Ile 
        115                 120                 125             


Ala Lys His Arg Gly Tyr Gly Asn Lys His Ala Lys Asp Ser Lys Asp 
    130                 135                 140                 


Thr Glu Ser Gly Lys Val Lys Lys Ala Ile Glu Phe Asn Arg Lys Thr 
145                 150                 155                 160 


Leu Ala Glu Lys Gly Tyr Arg Ser Val Gly Glu Tyr Leu Tyr Arg Glu 
                165                 170                 175     


Phe Phe Gln Gln Ser Arg Ile Ser Gln Asn Asn Gly Ala Thr Glu Phe 
            180                 185                 190         


Ile Asn Val Arg Asn Lys Ala Gly Asn Tyr Glu His Cys Val Ala Gln 
        195                 200                 205             


Asp Met Leu Lys Glu Glu Leu Glu Ser Ile Leu Asn Ala Gln Arg Gln 
    210                 215                 220                 


Phe Gly Phe Ser Leu Lys Gln Asp Phe Glu Asn Lys Leu Leu Thr Lys 
225                 230                 235                 240 


Ile Phe Glu Gln Arg Pro Leu Lys Ser Phe Ala Asp Lys Val Gly Asn 
                245                 250                 255     


Cys Cys Phe Ile Ala Gly Glu Lys Arg Thr Pro Lys Asp Ser Leu Ser 
            260                 265                 270         


Ala Ile Glu Phe Ile Ala Leu Ser Arg Thr Ile Asn Thr Leu Ile Asn 
        275                 280                 285             


Leu Ser Lys Glu Ser Gly Glu Ile Tyr Asn Arg Ala Ile Ile Leu Gln 
    290                 295                 300                 


Ile Val Glu Ser Thr Leu Lys Lys Gly Glu Ile Ser Tyr Lys Glu Leu 
305                 310                 315                 320 


Arg Glu Ile Ile Arg Leu Asp Glu Arg Leu Arg Phe Lys Asp Pro Arg 
                325                 330                 335     


Leu Asp Tyr Ser Arg Glu Ile Lys Glu Ala Glu Lys Val Lys Phe Leu 
            340                 345                 350         


Glu Phe Lys Gln Leu Lys Gly Phe Lys Lys Ala Leu Gly Glu Ser Phe 
        355                 360                 365             


Thr Thr Leu Ala Arg Ser Gln Leu Asp Glu Ile Ala Glu His Ile Ala 
    370                 375                 380                 


Leu Ile Lys Asp Arg Val Lys Leu Asn Glu Lys Leu Glu Ser Tyr Ala 
385                 390                 395                 400 


Leu Thr Lys Glu Gln Arg Glu Ala Leu Ser Asn Leu Ser Phe Ser Ala 
                405                 410                 415     


His Ile Asn Leu Ser Leu Gln Ala Leu Lys Gln Ile Leu Pro Phe Met 
            420                 425                 430         


Arg Gly Asp Asn Gly Glu Gln Cys Leu Asp Tyr Asp Glu Ser Val Glu 
        435                 440                 445             


Lys Ala Gly Leu Lys Ala Leu Ser Lys Asp Thr Leu Lys Gly Gln Met 
    450                 455                 460                 


Leu Pro Pro Leu Asn Glu Phe Glu Pro Tyr Leu Ser Asn Pro Val Val 
465                 470                 475                 480 


Ala Arg Ala Leu Ala Glu Tyr Arg Lys Val Leu Asn Ala Leu Leu Lys 
                485                 490                 495     


Gln Tyr Gly Ser Pro His Lys Ile His Ile Glu Tyr Ala Arg Glu Ala 
            500                 505                 510         


Lys Leu Ser Ser Thr Glu Arg Gln Lys Tyr Glu Lys Glu Gln Lys Asp 
        515                 520                 525             


Asn Tyr Ala Ala Asn Gln Ala Ala His Lys Lys Cys Gln Glu Leu Gly 
    530                 535                 540                 


Leu Glu Pro Ser Ser Thr Asn Leu Leu Lys Leu Lys Leu Trp Gln Glu 
545                 550                 555                 560 


Gln Gly Gly Leu Cys Leu Tyr Ser Gly Ala Lys Ile Thr Ile Ser Tyr 
                565                 570                 575     


Leu Gln Asp Pro Thr Ala Leu Gln Val Asp His Ile Tyr Pro Tyr Ser 
            580                 585                 590         


Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Cys Leu Val Leu Thr Lys 
        595                 600                 605             


Ala Asn Gln Glu Lys Gly Asn Arg Thr Pro Phe Glu Ala Phe Gly Thr 
    610                 615                 620                 


Asp Ser Ala Lys Trp Gly Val Ile Thr Thr Leu Ala Gln Lys Leu Pro 
625                 630                 635                 640 


His Lys Lys Arg Arg Arg Ile Leu Asn Thr Ala Phe Asn Asp Lys Glu 
                645                 650                 655     


Ala Gly Phe Lys Leu Arg Asn Leu Asn Asp Thr Ser Tyr Ile Ala Arg 
            660                 665                 670         


Leu Val Ala Asp Tyr Thr Glu Thr Tyr Leu Glu Phe Leu Pro Leu Val 
        675                 680                 685             


Glu Ser Glu Asn Thr Thr Leu Gly Lys Gly Gln Lys Gly Ser Lys Lys 
    690                 695                 700                 


His Ile Ala Ile Val Asn Gly Ala Leu Thr Ser Thr Met Arg Tyr Tyr 
705                 710                 715                 720 


Leu Gly Phe Ala Ser Lys Asp Arg Asp Asn His Leu His His Ala Leu 
                725                 730                 735     


Asp Ala Val Ile Ile Gly Phe Met Asn Asp Ser Val Ile Lys Ala Phe 
            740                 745                 750         


Ser Asp Phe Lys Lys Thr Gln Glu Thr Ser Lys Ala Ala Tyr Tyr Ala 
        755                 760                 765             


His Thr Leu Ser Lys Gln Glu Tyr Lys Lys Gln Arg Ala Phe Ile Gln 
    770                 775                 780                 


Leu Pro Ser Gly Glu Asn Phe Arg Ala Ser Val Leu Glu Lys Val Glu 
785                 790                 795                 800 


Ser Val Phe Val Ser Lys Pro Pro Arg Lys Arg Val Arg Gly Ala Leu 
                805                 810                 815     


His Glu Ala Thr Phe Tyr Ser Pro Asn Asp Pro Lys Leu Leu Lys Asn 
            820                 825                 830         


Tyr Gly Gly Thr Lys Gly Val Glu Arg Ala Leu Ala Leu Gly Lys Met 
        835                 840                 845             


Arg Lys Val Gly Ala Lys Ile Val Ser Asn Gly Ala Met Val Arg Val 
    850                 855                 860                 


Asp Ile Phe Arg His Lys Ser Ser Gly Lys Phe Tyr Gly Val Pro Val 
865                 870                 875                 880 


Tyr Thr Met Asp Phe Ala Leu Gly Ile Leu Pro Asn Lys Ala Val Val 
                885                 890                 895     


Val Gly Lys Asp Lys Asn Gly Val Ile Lys Asp Trp Leu Glu Met Asp 
            900                 905                 910         


Ser Ser Tyr Glu Phe Ile Phe Ser Leu Tyr Lys Asp Asp Leu Leu Leu 
        915                 920                 925             


Val Gln Lys Lys Glu Met Ala Glu Pro Glu Leu Cys Tyr Phe Met Ser 
    930                 935                 940                 


Phe Asn Ser Ser Ile Ala Gln Ile Ser Val Ala Lys His Asp Asn Asn 
945                 950                 955                 960 


Phe Ser Thr Leu Thr Lys Asn Gln Lys Leu Leu Phe Ser Asn Ala Thr 
                965                 970                 975     


Gln Glu Asp Val Ser Gly Lys Ser Ile Gly Ile Gln Asn Leu Gln Val 
            980                 985                 990         


Phe Glu Lys Trp Gln Val Ser Val  Leu Gly Glu Val Lys  Arg Thr Gln 
        995                 1000                 1005             


Ser Tyr  Pro Arg Glu Asn Ile  Ser Leu Ala Ser Lys  Ala Lys Lys 
    1010                 1015                 1020             


<210> 257
<211> 1024
<212> PRT
<213> Helicobacter mustelae

<400> 257
Met Ile Arg Thr Leu Gly Ile Asp Ile Gly Ile Ala Ser Ile Gly Trp 
1               5                   10                  15      


Ala Val Ile Glu Gly Glu Tyr Thr Asp Lys Gly Leu Glu Asn Lys Glu 
            20                  25                  30          


Ile Val Ala Ser Gly Val Arg Val Phe Thr Lys Ala Glu Asn Pro Lys 
        35                  40                  45              


Asn Lys Glu Ser Leu Ala Leu Pro Arg Thr Leu Ala Arg Ser Ala Arg 
    50                  55                  60                  


Arg Arg Asn Ala Arg Lys Lys Gly Arg Ile Gln Gln Val Lys His Tyr 
65                  70                  75                  80  


Leu Ser Lys Ala Leu Gly Leu Asp Leu Glu Cys Phe Val Gln Gly Glu 
                85                  90                  95      


Lys Leu Ala Thr Leu Phe Gln Thr Ser Lys Asp Phe Leu Ser Pro Trp 
            100                 105                 110         


Glu Leu Arg Glu Arg Ala Leu Tyr Arg Val Leu Asp Lys Glu Glu Leu 
        115                 120                 125             


Ala Arg Val Ile Leu His Ile Ala Lys Arg Arg Gly Tyr Asp Asp Ile 
    130                 135                 140                 


Thr Tyr Gly Val Glu Asp Asn Asp Ser Gly Lys Ile Lys Lys Ala Ile 
145                 150                 155                 160 


Ala Glu Asn Ser Lys Arg Ile Lys Glu Glu Gln Cys Lys Thr Ile Gly 
                165                 170                 175     


Glu Met Met Tyr Lys Leu Tyr Phe Gln Lys Ser Leu Asn Val Arg Asn 
            180                 185                 190         


Lys Lys Glu Ser Tyr Asn Arg Cys Val Gly Arg Ser Glu Leu Arg Glu 
        195                 200                 205             


Glu Leu Lys Thr Ile Phe Gln Ile Gln Gln Glu Leu Lys Ser Pro Trp 
    210                 215                 220                 


Val Asn Glu Glu Leu Ile Tyr Lys Leu Leu Gly Asn Pro Asp Ala Gln 
225                 230                 235                 240 


Ser Lys Gln Glu Arg Glu Gly Leu Ile Phe Tyr Gln Arg Pro Leu Lys 
                245                 250                 255     


Gly Phe Gly Asp Lys Ile Gly Lys Cys Ser His Ile Lys Lys Gly Glu 
            260                 265                 270         


Asn Ser Pro Tyr Arg Ala Cys Lys His Ala Pro Ser Ala Glu Glu Phe 
        275                 280                 285             


Val Ala Leu Thr Lys Ser Ile Asn Phe Leu Lys Asn Leu Thr Asn Arg 
    290                 295                 300                 


His Gly Leu Cys Phe Ser Gln Glu Asp Met Cys Val Tyr Leu Gly Lys 
305                 310                 315                 320 


Ile Leu Gln Glu Ala Gln Lys Asn Glu Lys Gly Leu Thr Tyr Ser Lys 
                325                 330                 335     


Leu Lys Leu Leu Leu Asp Leu Pro Ser Asp Phe Glu Phe Leu Gly Leu 
            340                 345                 350         


Asp Tyr Ser Gly Lys Asn Pro Glu Lys Ala Val Phe Leu Ser Leu Pro 
        355                 360                 365             


Ser Thr Phe Lys Leu Asn Lys Ile Thr Gln Asp Arg Lys Thr Gln Asp 
    370                 375                 380                 


Lys Ile Ala Asn Ile Leu Gly Ala Asn Lys Asp Trp Glu Ala Ile Leu 
385                 390                 395                 400 


Lys Glu Leu Glu Ser Leu Gln Leu Ser Lys Glu Gln Ile Gln Thr Ile 
                405                 410                 415     


Lys Asp Ala Lys Leu Asn Phe Ser Lys His Ile Asn Leu Ser Leu Glu 
            420                 425                 430         


Ala Leu Tyr His Leu Leu Pro Leu Met Arg Glu Gly Lys Arg Tyr Asp 
        435                 440                 445             


Glu Gly Val Glu Ile Leu Gln Glu Arg Gly Ile Phe Ser Lys Pro Gln 
    450                 455                 460                 


Pro Lys Asn Arg Gln Leu Leu Pro Pro Leu Ser Glu Leu Ala Lys Glu 
465                 470                 475                 480 


Glu Ser Tyr Phe Asp Ile Pro Asn Pro Val Leu Arg Arg Ala Leu Ser 
                485                 490                 495     


Glu Phe Arg Lys Val Val Asn Ala Leu Leu Glu Lys Tyr Gly Gly Phe 
            500                 505                 510         


His Tyr Phe His Ile Glu Leu Thr Arg Asp Val Cys Lys Ala Lys Ser 
        515                 520                 525             


Ala Arg Met Gln Leu Glu Lys Ile Asn Lys Lys Asn Lys Ser Glu Asn 
    530                 535                 540                 


Asp Ala Ala Ser Gln Leu Leu Glu Val Leu Gly Leu Pro Asn Thr Tyr 
545                 550                 555                 560 


Asn Asn Arg Leu Lys Cys Lys Leu Trp Lys Gln Gln Glu Glu Tyr Cys 
                565                 570                 575     


Leu Tyr Ser Gly Glu Lys Ile Thr Ile Asp His Leu Lys Asp Gln Arg 
            580                 585                 590         


Ala Leu Gln Ile Asp His Ala Phe Pro Leu Ser Arg Ser Leu Asp Asp 
        595                 600                 605             


Ser Gln Ser Asn Lys Val Leu Cys Leu Thr Ser Ser Asn Gln Glu Lys 
    610                 615                 620                 


Ser Asn Lys Thr Pro Tyr Glu Trp Leu Gly Ser Asp Glu Lys Lys Trp 
625                 630                 635                 640 


Asp Met Tyr Val Gly Arg Val Tyr Ser Ser Asn Phe Ser Pro Ser Lys 
                645                 650                 655     


Lys Arg Lys Leu Thr Gln Lys Asn Phe Lys Glu Arg Asn Glu Glu Asp 
            660                 665                 670         


Phe Leu Ala Arg Asn Leu Val Asp Thr Gly Tyr Ile Gly Arg Val Thr 
        675                 680                 685             


Lys Glu Tyr Ile Lys His Ser Leu Ser Phe Leu Pro Leu Pro Asp Gly 
    690                 695                 700                 


Lys Lys Glu His Ile Arg Ile Ile Ser Gly Ser Met Thr Ser Thr Met 
705                 710                 715                 720 


Arg Ser Phe Trp Gly Val Gln Glu Lys Asn Arg Asp His His Leu His 
                725                 730                 735     


His Ala Gln Asp Ala Ile Ile Ile Ala Cys Ile Glu Pro Ser Met Ile 
            740                 745                 750         


Gln Lys Tyr Thr Thr Tyr Leu Lys Asp Lys Glu Thr His Arg Leu Lys 
        755                 760                 765             


Ser His Gln Lys Ala Gln Ile Leu Arg Glu Gly Asp His Lys Leu Ser 
    770                 775                 780                 


Leu Arg Trp Pro Met Ser Asn Phe Lys Asp Lys Ile Gln Glu Ser Ile 
785                 790                 795                 800 


Gln Asn Ile Ile Pro Ser His His Val Ser His Lys Val Thr Gly Glu 
                805                 810                 815     


Leu His Gln Glu Thr Val Arg Thr Lys Glu Phe Tyr Tyr Gln Ala Phe 
            820                 825                 830         


Gly Gly Glu Glu Gly Val Lys Lys Ala Leu Lys Phe Gly Lys Ile Arg 
        835                 840                 845             


Glu Ile Asn Gln Gly Ile Val Asp Asn Gly Ala Met Val Arg Val Asp 
    850                 855                 860                 


Ile Phe Lys Ser Lys Asp Lys Gly Lys Phe Tyr Ala Val Pro Ile Tyr 
865                 870                 875                 880 


Thr Tyr Asp Phe Ala Ile Gly Lys Leu Pro Asn Lys Ala Ile Val Gln 
                885                 890                 895     


Gly Lys Lys Asn Gly Ile Ile Lys Asp Trp Leu Glu Met Asp Glu Asn 
            900                 905                 910         


Tyr Glu Phe Cys Phe Ser Leu Phe Lys Asn Asp Cys Ile Lys Ile Gln 
        915                 920                 925             


Thr Lys Glu Met Gln Glu Ala Val Leu Ala Ile Tyr Lys Ser Thr Asn 
    930                 935                 940                 


Ser Ala Lys Ala Thr Ile Glu Leu Glu His Leu Ser Lys Tyr Ala Leu 
945                 950                 955                 960 


Lys Asn Glu Asp Glu Glu Lys Met Phe Thr Asp Thr Asp Lys Glu Lys 
                965                 970                 975     


Asn Lys Thr Met Thr Arg Glu Ser Cys Gly Ile Gln Gly Leu Lys Val 
            980                 985                 990         


Phe Gln Lys Val Lys Leu Ser Val  Leu Gly Glu Val Leu  Glu His Lys 
        995                 1000                 1005             


Pro Arg  Asn Arg Gln Asn Ile  Ala Leu Lys Thr Thr  Pro Lys His 
    1010                 1015                 1020             


Val 
    


<210> 258
<211> 1688
<212> PRT
<213> Ignavibacterium album

<400> 258
Met Glu Phe Lys Lys Val Leu Gly Leu Asp Ile Gly Thr Asn Ser Ile 
1               5                   10                  15      


Gly Cys Ala Leu Leu Ser Leu Pro Lys Ser Ile Gln Asp Tyr Gly Lys 
            20                  25                  30          


Gly Gly Arg Leu Glu Trp Leu Thr Ser Arg Val Ile Pro Leu Asp Ala 
        35                  40                  45              


Asp Tyr Met Lys Ala Phe Ile Asp Gly Lys Asn Gly Leu Pro Gln Val 
    50                  55                  60                  


Ile Thr Pro Ala Gly Lys Arg Arg Gln Lys Arg Gly Ser Arg Arg Leu 
65                  70                  75                  80  


Lys His Arg Tyr Lys Leu Arg Arg Ser Arg Leu Ile Arg Val Phe Lys 
                85                  90                  95      


Thr Leu Asn Trp Leu Pro Glu Asp Phe Pro Leu Asp Asn Pro Lys Arg 
            100                 105                 110         


Ile Lys Glu Thr Ile Ser Thr Glu Gly Lys Phe Ser Phe Arg Ile Ser 
        115                 120                 125             


Asp Tyr Val Pro Ile Ser Asp Glu Ser Tyr Arg Glu Phe Tyr Arg Glu 
    130                 135                 140                 


Phe Gly Tyr Pro Glu Asn Glu Ile Glu Gln Val Ile Glu Glu Ile Asn 
145                 150                 155                 160 


Phe Arg Arg Lys Thr Lys Gly Lys Asn Lys Asn Pro Met Ile Lys Leu 
                165                 170                 175     


Leu Pro Glu Asp Trp Val Val Tyr Tyr Leu Arg Lys Lys Ala Leu Ile 
            180                 185                 190         


Lys Pro Thr Thr Lys Glu Glu Leu Ile Arg Ile Ile Tyr Leu Phe Asn 
        195                 200                 205             


Gln Arg Arg Gly Phe Lys Ser Ser Arg Lys Asp Leu Thr Glu Thr Ala 
    210                 215                 220                 


Ile Leu Asp Tyr Asp Glu Phe Ala Lys Arg Leu Ala Glu Lys Glu Lys 
225                 230                 235                 240 


Tyr Ser Ala Glu Asn Tyr Glu Thr Lys Phe Val Ser Ile Thr Lys Val 
                245                 250                 255     


Lys Glu Val Val Glu Leu Lys Thr Asp Gly Arg Lys Gly Lys Lys Arg 
            260                 265                 270         


Phe Lys Val Ile Leu Glu Asp Ser Arg Ile Glu Pro Tyr Glu Ile Glu 
        275                 280                 285             


Arg Lys Glu Lys Pro Asp Trp Glu Gly Lys Glu Tyr Thr Phe Leu Val 
    290                 295                 300                 


Thr Gln Lys Leu Glu Lys Gly Lys Phe Lys Gln Asn Lys Pro Asp Leu 
305                 310                 315                 320 


Pro Lys Glu Glu Asp Trp Ala Leu Cys Thr Thr Ala Leu Asp Asn Arg 
                325                 330                 335     


Met Gly Ser Lys His Pro Gly Glu Phe Phe Phe Asp Glu Leu Leu Lys 
            340                 345                 350         


Ala Phe Lys Glu Lys Arg Gly Tyr Lys Ile Arg Gln Tyr Pro Val Asn 
        355                 360                 365             


Arg Trp Arg Tyr Lys Lys Glu Leu Glu Phe Ile Trp Thr Lys Gln Cys 
    370                 375                 380                 


Gln Leu Asn Pro Glu Leu Asn Asn Leu Asn Ile Asn Lys Glu Ile Leu 
385                 390                 395                 400 


Arg Lys Leu Ala Thr Val Leu Tyr Pro Ser Gln Ser Lys Phe Phe Gly 
                405                 410                 415     


Pro Lys Ile Lys Glu Phe Glu Asn Ser Asp Val Leu His Ile Ile Ser 
            420                 425                 430         


Glu Asp Ile Ile Tyr Tyr Gln Arg Asp Leu Lys Ser Gln Lys Ser Leu 
        435                 440                 445             


Ile Ser Glu Cys Arg Tyr Glu Lys Arg Lys Gly Ile Asp Gly Glu Ile 
    450                 455                 460                 


Tyr Gly Leu Lys Cys Ile Pro Lys Ser Ser Pro Leu Tyr Gln Glu Phe 
465                 470                 475                 480 


Arg Ile Trp Gln Asp Ile His Asn Ile Lys Val Ile Arg Lys Glu Ser 
                485                 490                 495     


Glu Val Asn Gly Lys Lys Lys Ile Asn Ile Asp Glu Thr Gln Leu Tyr 
            500                 505                 510         


Ile Asn Glu Asn Ile Lys Glu Lys Leu Phe Glu Leu Phe Asn Ser Lys 
        515                 520                 525             


Asp Ser Leu Ser Glu Lys Asp Ile Leu Glu Leu Ile Ser Leu Asn Ile 
    530                 535                 540                 


Ile Asn Ser Gly Ile Lys Ile Ser Lys Lys Glu Glu Glu Thr Thr His 
545                 550                 555                 560 


Arg Ile Asn Leu Phe Ala Asn Arg Lys Glu Leu Lys Gly Asn Glu Thr 
                565                 570                 575     


Lys Ser Arg Tyr Arg Lys Val Phe Lys Lys Leu Gly Phe Asp Gly Glu 
            580                 585                 590         


Tyr Ile Leu Asn His Pro Ser Lys Leu Asn Arg Leu Trp His Ser Asp 
        595                 600                 605             


Tyr Ser Asn Asp Tyr Ala Asp Lys Glu Lys Thr Glu Lys Ser Ile Leu 
    610                 615                 620                 


Ser Ser Leu Gly Trp Lys Asn Arg Asn Gly Lys Trp Glu Lys Ser Lys 
625                 630                 635                 640 


Asn Tyr Asp Val Phe Asn Leu Pro Leu Glu Val Ala Lys Ala Ile Ala 
                645                 650                 655     


Asn Leu Pro Pro Leu Lys Lys Glu Tyr Gly Ser Tyr Ser Ala Leu Ala 
            660                 665                 670         


Ile Arg Lys Met Leu Val Val Met Arg Asp Gly Lys Tyr Trp Gln His 
        675                 680                 685             


Pro Asp Gln Ile Ala Lys Asp Gln Glu Asn Thr Ser Leu Met Leu Phe 
    690                 695                 700                 


Asp Lys Asn Leu Ile Gln Leu Thr Asn Asn Gln Arg Lys Val Leu Asn 
705                 710                 715                 720 


Lys Tyr Leu Leu Thr Leu Ala Glu Val Gln Lys Arg Ser Thr Leu Ile 
                725                 730                 735     


Lys Gln Lys Leu Asn Glu Ile Glu His Asn Pro Tyr Lys Leu Glu Leu 
            740                 745                 750         


Val Ser Asp Gln Asp Leu Glu Lys Gln Val Leu Lys Ser Phe Leu Glu 
        755                 760                 765             


Lys Lys Asn Glu Ser Asp Tyr Leu Lys Gly Leu Lys Thr Tyr Gln Ala 
    770                 775                 780                 


Gly Tyr Leu Ile Tyr Gly Lys His Ser Glu Lys Asp Val Pro Ile Val 
785                 790                 795                 800 


Asn Ser Pro Asp Glu Leu Gly Glu Tyr Ile Arg Lys Lys Leu Pro Asn 
                805                 810                 815     


Asn Ser Leu Arg Asn Pro Ile Val Glu Gln Val Ile Arg Glu Thr Ile 
            820                 825                 830         


Phe Ile Val Arg Asp Val Trp Lys Ser Phe Gly Ile Ile Asp Glu Ile 
        835                 840                 845             


His Ile Glu Leu Gly Arg Glu Leu Lys Asn Asn Ser Glu Glu Arg Lys 
    850                 855                 860                 


Lys Thr Ser Glu Ser Gln Glu Lys Asn Phe Gln Glu Lys Glu Arg Ala 
865                 870                 875                 880 


Arg Lys Leu Leu Lys Glu Leu Leu Asn Ser Ser Asn Phe Glu His Tyr 
                885                 890                 895     


Asp Glu Asn Gly Asn Lys Ile Phe Ser Ser Phe Thr Val Asn Pro Asn 
            900                 905                 910         


Pro Asp Ser Pro Leu Asp Ile Glu Lys Phe Arg Ile Trp Lys Asn Gln 
        915                 920                 925             


Ser Gly Leu Thr Asp Glu Glu Leu Asn Lys Lys Leu Lys Asp Glu Lys 
    930                 935                 940                 


Ile Pro Thr Glu Ile Glu Val Lys Lys Tyr Ile Leu Trp Leu Thr Gln 
945                 950                 955                 960 


Lys Cys Arg Ser Pro Tyr Thr Gly Lys Ile Ile Pro Leu Ser Lys Leu 
                965                 970                 975     


Phe Asp Ser Asn Val Tyr Glu Ile Glu His Ile Ile Pro Arg Ser Lys 
            980                 985                 990         


Met Lys Asn Asp Ser Thr Asn Asn  Leu Val Ile Cys Glu  Leu Gly Val 
        995                 1000                 1005             


Asn Lys  Ala Lys Gly Asp Arg  Leu Ala Ala Asn Phe  Ile Ser Glu 
    1010                 1015                 1020             


Ser Asn  Gly Lys Cys Lys Phe  Gly Glu Val Glu Tyr  Thr Leu Leu 
    1025                 1030                 1035             


Lys Tyr  Gly Asp Tyr Leu Gln  Tyr Cys Lys Asp Thr  Phe Lys Tyr 
    1040                 1045                 1050             


Gln Lys  Ala Lys Tyr Lys Asn  Leu Leu Ala Thr Glu  Pro Pro Glu 
    1055                 1060                 1065             


Asp Phe  Ile Glu Arg Gln Ile  Asn Asp Thr Arg Tyr  Ile Gly Arg 
    1070                 1075                 1080             


Lys Leu  Ala Glu Leu Leu Thr  Pro Val Val Lys Asp  Ser Lys Asn 
    1085                 1090                 1095             


Ile Ile  Phe Thr Ile Gly Ser  Ile Thr Ser Glu Leu  Lys Ile Thr 
    1100                 1105                 1110             


Trp Gly  Leu Asn Gly Val Trp  Lys Asp Ile Leu Arg  Pro Arg Phe 
    1115                 1120                 1125             


Lys Arg  Leu Glu Ser Ile Ile  Asn Lys Lys Leu Ile  Phe Gln Asp 
    1130                 1135                 1140             


Glu Asp  Asp Pro Asn Lys Tyr  His Phe Asp Leu Ser  Ile Asn Pro 
    1145                 1150                 1155             


Gln Leu  Asp Lys Glu Gly Leu  Lys Arg Leu Asp His  Arg His His 
    1160                 1165                 1170             


Ala Leu  Asp Ala Thr Ile Ile  Ala Ala Thr Thr Arg  Glu His Val 
    1175                 1180                 1185             


Arg Tyr  Leu Asn Ser Leu Asn  Ala Ala Asp Asn Asp  Glu Glu Lys 
    1190                 1195                 1200             


Arg Glu  Tyr Phe Leu Ser Leu  Cys Asn His Lys Ile  Arg Asp Phe 
    1205                 1210                 1215             


Lys Leu  Pro Trp Glu Asn Phe  Thr Ser Glu Val Lys  Ser Lys Leu 
    1220                 1225                 1230             


Leu Ser  Cys Val Val Ser Tyr  Lys Glu Ser Lys Pro  Ile Leu Ser 
    1235                 1240                 1245             


Asp Pro  Phe Asn Lys Tyr Leu  Lys Trp Glu Tyr Lys  Asn Gly Lys 
    1250                 1255                 1260             


Trp Gln  Lys Val Phe Ala Ile  Gln Ile Lys Asn Asp  Arg Trp Lys 
    1265                 1270                 1275             


Ala Val  Arg Arg Ser Met Phe  Lys Glu Pro Ile Gly  Thr Val Trp 
    1280                 1285                 1290             


Ile Lys  Lys Ile Lys Glu Val  Ser Leu Lys Glu Ala  Ile Lys Ile 
    1295                 1300                 1305             


Gln Ala  Ile Trp Glu Glu Val  Lys Asn Asp Pro Val  Arg Lys Lys 
    1310                 1315                 1320             


Lys Glu  Lys Tyr Ile Tyr Asp  Asp Tyr Ala Gln Lys  Val Ile Ala 
    1325                 1330                 1335             


Lys Ile  Val Gln Glu Leu Gly  Leu Ser Ser Ser Met  Arg Lys Gln 
    1340                 1345                 1350             


Asp Asp  Glu Lys Leu Asn Lys  Phe Ile Asn Glu Ala  Lys Val Ser 
    1355                 1360                 1365             


Ala Gly  Val Asn Lys Asn Leu  Asn Thr Thr Asn Lys  Thr Ile Tyr 
    1370                 1375                 1380             


Asn Leu  Glu Gly Arg Phe Tyr  Glu Lys Ile Lys Val  Ala Glu Tyr 
    1385                 1390                 1395             


Val Leu  Tyr Lys Ala Lys Arg  Met Pro Leu Asn Lys  Lys Glu Tyr 
    1400                 1405                 1410             


Ile Glu  Lys Leu Ser Leu Gln  Lys Met Phe Asn Asp  Leu Pro Asn 
    1415                 1420                 1425             


Phe Ile  Leu Glu Lys Ser Ile  Leu Asp Asn Tyr Pro  Glu Ile Leu 
    1430                 1435                 1440             


Lys Glu  Leu Glu Ser Asp Asn  Lys Tyr Ile Ile Glu  Pro His Lys 
    1445                 1450                 1455             


Lys Asn  Asn Pro Val Asn Arg  Leu Leu Leu Glu His  Ile Leu Glu 
    1460                 1465                 1470             


Tyr His  Asn Asn Pro Lys Glu  Ala Phe Ser Thr Glu  Gly Leu Glu 
    1475                 1480                 1485             


Lys Leu  Asn Lys Lys Ala Ile  Asn Lys Ile Gly Lys  Pro Ile Lys 
    1490                 1495                 1500             


Tyr Ile  Thr Arg Leu Asp Gly  Asp Ile Asn Glu Glu  Glu Ile Phe 
    1505                 1510                 1515             


Arg Gly  Ala Val Phe Glu Thr  Asp Lys Gly Ser Asn  Val Tyr Phe 
    1520                 1525                 1530             


Val Met  Tyr Glu Asn Asn Gln  Thr Lys Asp Arg Glu  Phe Leu Lys 
    1535                 1540                 1545             


Pro Asn  Pro Ser Ile Ser Val  Leu Lys Ala Ile Glu  His Lys Asn 
    1550                 1555                 1560             


Lys Ile  Asp Phe Phe Ala Pro  Asn Arg Leu Gly Phe  Ser Arg Ile 
    1565                 1570                 1575             


Ile Leu  Ser Pro Gly Asp Leu  Val Tyr Val Pro Thr  Asn Asp Gln 
    1580                 1585                 1590             


Tyr Val  Leu Ile Lys Asp Asn  Ser Ser Asn Glu Thr  Ile Ile Asn 
    1595                 1600                 1605             


Trp Asp  Asp Asn Glu Phe Ile  Ser Asn Arg Ile Tyr  Gln Val Lys 
    1610                 1615                 1620             


Lys Phe  Thr Gly Asn Ser Cys  Tyr Phe Leu Lys Asn  Asp Ile Ala 
    1625                 1630                 1635             


Ser Leu  Ile Leu Ser Tyr Ser  Ala Ser Asn Gly Val  Gly Glu Phe 
    1640                 1645                 1650             


Gly Ser  Gln Asn Ile Ser Glu  Tyr Ser Val Asp Asp  Pro Pro Ile 
    1655                 1660                 1665             


Arg Ile  Lys Asp Val Cys Ile  Lys Ile Arg Val Asp  Arg Leu Gly 
    1670                 1675                 1680             


Asn Val  Arg Pro Leu 
    1685             


<210> 259
<211> 1092
<212> PRT
<213> Ilyobacter polytropus

<400> 259
Met Lys Tyr Ser Ile Gly Leu Asp Ile Gly Ile Ala Ser Val Gly Trp 
1               5                   10                  15      


Ser Val Ile Asn Lys Asp Lys Glu Arg Ile Glu Asp Met Gly Val Arg 
            20                  25                  30          


Ile Phe Gln Lys Ala Glu Asn Pro Lys Asp Gly Ser Ser Leu Ala Ser 
        35                  40                  45              


Ser Arg Arg Glu Lys Arg Gly Ser Arg Arg Arg Asn Arg Arg Lys Lys 
    50                  55                  60                  


His Arg Leu Asp Arg Ile Lys Asn Ile Leu Cys Glu Ser Gly Leu Val 
65                  70                  75                  80  


Lys Lys Asn Glu Ile Glu Lys Ile Tyr Lys Asn Ala Tyr Leu Lys Ser 
                85                  90                  95      


Pro Trp Glu Leu Arg Ala Lys Ser Leu Glu Ala Lys Ile Ser Asn Lys 
            100                 105                 110         


Glu Ile Ala Gln Ile Leu Leu His Ile Ala Lys Arg Arg Gly Phe Lys 
        115                 120                 125             


Ser Phe Arg Lys Thr Asp Arg Asn Ala Asp Asp Thr Gly Lys Leu Leu 
    130                 135                 140                 


Ser Gly Ile Gln Glu Asn Lys Lys Ile Met Glu Glu Lys Gly Tyr Leu 
145                 150                 155                 160 


Thr Ile Gly Asp Met Val Ala Lys Asp Pro Lys Phe Asn Thr His Val 
                165                 170                 175     


Arg Asn Lys Ala Gly Ser Tyr Leu Phe Ser Phe Ser Arg Lys Leu Leu 
            180                 185                 190         


Glu Asp Glu Val Arg Lys Ile Gln Ala Lys Gln Lys Glu Leu Gly Asn 
        195                 200                 205             


Thr His Phe Thr Asp Asp Val Leu Glu Lys Tyr Ile Glu Val Phe Asn 
    210                 215                 220                 


Ser Gln Arg Asn Phe Asp Glu Gly Pro Ser Lys Pro Ser Pro Tyr Tyr 
225                 230                 235                 240 


Ser Glu Ile Gly Gln Ile Ala Lys Met Ile Gly Asn Cys Thr Phe Glu 
                245                 250                 255     


Ser Ser Glu Lys Arg Thr Ala Lys Asn Thr Trp Ser Gly Glu Arg Phe 
            260                 265                 270         


Val Phe Leu Gln Lys Leu Asn Asn Phe Arg Ile Val Gly Leu Ser Gly 
        275                 280                 285             


Lys Arg Pro Leu Thr Glu Glu Glu Arg Asp Ile Val Glu Lys Glu Val 
    290                 295                 300                 


Tyr Leu Lys Lys Glu Val Arg Tyr Glu Lys Leu Arg Lys Ile Leu Tyr 
305                 310                 315                 320 


Leu Lys Glu Glu Glu Arg Phe Gly Asp Leu Asn Tyr Ser Lys Asp Glu 
                325                 330                 335     


Lys Gln Asp Lys Lys Thr Glu Lys Thr Lys Phe Ile Ser Leu Ile Gly 
            340                 345                 350         


Asn Tyr Thr Ile Lys Lys Leu Asn Leu Ser Glu Lys Leu Lys Ser Glu 
        355                 360                 365             


Ile Glu Glu Asp Lys Ser Lys Leu Asp Lys Ile Ile Glu Ile Leu Thr 
    370                 375                 380                 


Phe Asn Lys Ser Asp Lys Thr Ile Glu Ser Asn Leu Lys Lys Leu Glu 
385                 390                 395                 400 


Leu Ser Arg Glu Asp Ile Glu Ile Leu Leu Ser Glu Glu Phe Ser Gly 
                405                 410                 415     


Thr Leu Asn Leu Ser Leu Lys Ala Ile Lys Lys Ile Leu Pro Tyr Leu 
            420                 425                 430         


Glu Lys Gly Leu Ser Tyr Asn Glu Ala Cys Glu Lys Ala Asp Tyr Asp 
        435                 440                 445             


Tyr Lys Asn Asn Gly Ile Lys Phe Lys Arg Gly Glu Leu Leu Pro Val 
    450                 455                 460                 


Val Asp Lys Asp Leu Ile Ala Asn Pro Val Val Leu Arg Ala Ile Ser 
465                 470                 475                 480 


Gln Thr Arg Lys Val Val Asn Ala Ile Ile Arg Lys Tyr Gly Thr Pro 
                485                 490                 495     


His Thr Ile His Val Glu Val Ala Arg Asp Leu Ala Lys Ser Tyr Asp 
            500                 505                 510         


Asp Arg Gln Thr Ile Ile Lys Glu Asn Lys Lys Arg Glu Leu Glu Asn 
        515                 520                 525             


Glu Lys Thr Lys Lys Phe Ile Ser Glu Glu Phe Gly Ile Lys Asn Val 
    530                 535                 540                 


Lys Gly Lys Leu Leu Leu Lys Tyr Arg Leu Tyr Gln Glu Gln Glu Gly 
545                 550                 555                 560 


Arg Cys Ala Tyr Ser Arg Lys Glu Leu Ser Leu Ser Glu Val Ile Leu 
                565                 570                 575     


Asp Glu Ser Met Thr Asp Ile Asp His Ile Ile Pro Tyr Ser Arg Ser 
            580                 585                 590         


Met Asp Asp Ser Tyr Ser Asn Lys Val Leu Val Leu Ser Gly Glu Asn 
        595                 600                 605             


Arg Lys Lys Ser Asn Leu Leu Pro Lys Glu Tyr Phe Asp Arg Gln Gly 
    610                 615                 620                 


Arg Asp Trp Asp Thr Phe Val Leu Asn Val Lys Ala Met Lys Ile His 
625                 630                 635                 640 


Pro Arg Lys Lys Ser Asn Leu Leu Lys Glu Lys Phe Thr Arg Glu Asp 
                645                 650                 655     


Asn Lys Asp Trp Lys Ser Arg Ala Leu Asn Asp Thr Arg Tyr Ile Ser 
            660                 665                 670         


Arg Phe Val Ala Asn Tyr Leu Glu Asn Ala Leu Glu Tyr Arg Asp Asp 
        675                 680                 685             


Ser Pro Lys Lys Arg Val Phe Met Ile Pro Gly Gln Leu Thr Ala Gln 
    690                 695                 700                 


Leu Arg Ala Arg Trp Arg Leu Asn Lys Val Arg Glu Asn Gly Asp Leu 
705                 710                 715                 720 


His His Ala Leu Asp Ala Ala Val Val Ala Val Thr Asp Gln Lys Ala 
                725                 730                 735     


Ile Asn Asn Ile Ser Asn Ile Ser Arg Tyr Lys Glu Leu Lys Asn Cys 
            740                 745                 750         


Lys Asp Val Ile Pro Ser Ile Glu Tyr His Ala Asp Glu Glu Thr Gly 
        755                 760                 765             


Glu Val Tyr Phe Glu Glu Val Lys Asp Thr Arg Phe Pro Met Pro Trp 
    770                 775                 780                 


Ser Gly Phe Asp Leu Glu Leu Gln Lys Arg Leu Glu Ser Glu Asn Pro 
785                 790                 795                 800 


Arg Glu Glu Phe Tyr Asn Leu Leu Ser Asp Lys Arg Tyr Leu Gly Trp 
                805                 810                 815     


Phe Asn Tyr Glu Glu Gly Phe Ile Glu Lys Leu Arg Pro Val Phe Val 
            820                 825                 830         


Ser Arg Met Pro Asn Arg Gly Val Lys Gly Gln Ala His Gln Glu Thr 
        835                 840                 845             


Ile Arg Ser Ser Lys Lys Ile Ser Asn Gln Ile Ala Val Ser Lys Lys 
    850                 855                 860                 


Pro Leu Asn Ser Ile Lys Leu Lys Asp Leu Glu Lys Met Gln Gly Arg 
865                 870                 875                 880 


Asp Thr Asp Arg Lys Leu Tyr Glu Ala Leu Lys Asn Arg Leu Glu Glu 
                885                 890                 895     


Tyr Asp Asp Lys Pro Glu Lys Ala Phe Ala Glu Pro Phe Tyr Lys Pro 
            900                 905                 910         


Thr Asn Ser Gly Lys Arg Gly Pro Leu Val Arg Gly Ile Lys Val Glu 
        915                 920                 925             


Glu Lys Gln Asn Val Gly Val Tyr Val Asn Gly Gly Gln Ala Ser Asn 
    930                 935                 940                 


Gly Ser Met Val Arg Ile Asp Val Phe Arg Lys Asn Gly Lys Phe Tyr 
945                 950                 955                 960 


Thr Val Pro Ile Tyr Val His Gln Thr Leu Leu Lys Glu Leu Pro Asn 
                965                 970                 975     


Arg Ala Ile Asn Gly Lys Pro Tyr Lys Asp Trp Asp Leu Ile Asp Gly 
            980                 985                 990         


Ser Phe Glu Phe Leu Tyr Ser Phe  Tyr Pro Asn Asp Leu  Ile Glu Ile 
        995                 1000                 1005             


Glu Phe  Gly Lys Ser Lys Ser  Ile Lys Asn Asp Asn  Lys Leu Thr 
    1010                 1015                 1020             


Lys Thr  Glu Ile Pro Glu Val  Asn Leu Ser Glu Val  Leu Gly Tyr 
    1025                 1030                 1035             


Tyr Arg  Gly Met Asp Thr Ser  Thr Gly Ala Ala Thr  Ile Asp Thr 
    1040                 1045                 1050             


Gln Asp  Gly Lys Ile Gln Met  Arg Ile Gly Ile Lys  Thr Val Lys 
    1055                 1060                 1065             


Asn Ile  Lys Lys Tyr Gln Val  Asp Val Leu Gly Asn  Val Tyr Lys 
    1070                 1075                 1080             


Val Lys  Arg Glu Lys Arg Gln  Thr Phe 
    1085                 1090         


<210> 260
<211> 1354
<212> PRT
<213> Indibacter alkaliphilus


<220>
<223> Indibacter alkaliphilus LW1

<400> 260
Met Lys Lys Ile Leu Gly Leu Asp Leu Gly Thr Thr Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ile Lys Glu Pro Glu Lys Asp Val Val Gly Ser Glu Ile Val 
            20                  25                  30          


Asp Met Gly Val Arg Ile Val Pro Leu Ser Ser Asp Glu Glu Asn Asp 
        35                  40                  45              


Phe Ala Lys Gly Asn Thr Ile Ser Ile Asn Ala Asp Arg Thr Leu Lys 
    50                  55                  60                  


Arg Gly Ala Arg Arg Asn Leu Gln Arg Phe Lys Gln Arg Arg Asn Ala 
65                  70                  75                  80  


Leu Leu Glu Thr Phe Lys Glu Lys Asn Leu Ile Pro Ser Asn Phe Gln 
                85                  90                  95      


Tyr Ala Glu Asp Gly Pro Ser Ser Thr Phe Ser Thr Leu Lys Leu Arg 
            100                 105                 110         


Asp Lys Ala Ala Lys Glu Lys Ile Glu Leu Asp Asp Phe Val Lys Val 
        115                 120                 125             


Leu Leu Gln Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala 
    130                 135                 140                 


Met Ser Glu Glu Asp Glu Gly Thr Ala Ile Asp Ser Met Gly Ile Ala 
145                 150                 155                 160 


Lys Glu Leu Tyr Glu Asn Asp Leu Thr Pro Gly Gln Trp Val Tyr Glu 
                165                 170                 175     


Ala Leu Lys Asn Gly Arg Lys Asn Val Pro Asp Phe Tyr Arg Ser Asp 
            180                 185                 190         


Leu Gln Glu Glu Phe Lys Lys Ile Val Asn Tyr Gln Ser Glu Phe Tyr 
        195                 200                 205             


Pro Asp Ile Leu Asn Thr Ser Phe Val Glu Asp Trp Met Gly Lys Ala 
    210                 215                 220                 


Ser Thr Pro Thr Lys Gln Tyr Phe Asn Lys Arg Gly Val Gln Leu Ala 
225                 230                 235                 240 


Glu Asn Lys Gly Lys Arg Glu Glu Arg Arg Leu Gln Glu Tyr Lys Trp 
                245                 250                 255     


Arg Ala Glu Ala Val Asn Phe Lys Ile Asp Leu Ser Glu Ile Ala Leu 
            260                 265                 270         


Ile Leu Ser Gln Ile Asn Ser Gln Ile Ser Asn Ser Ser Gly Tyr Leu 
        275                 280                 285             


Gly Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Lys Asn Leu Thr 
    290                 295                 300                 


Val Gly Gln Tyr Leu Tyr Gln Gln Val Lys Lys Asn Pro His Thr Arg 
305                 310                 315                 320 


Leu Lys Gly Gln Val Phe Tyr Arg Gln Asp Tyr Leu Asp Glu Phe Glu 
                325                 330                 335     


Lys Ile Trp Ser Val Gln Ser Ser Phe Tyr Pro Gln Leu Asn Asp Glu 
            340                 345                 350         


Leu Lys Gln Glu Val Arg Asp Val Thr Ile Phe Phe Gln Arg Arg Leu 
        355                 360                 365             


Lys Ser Gln Lys His Leu Ile Ser Asn Cys Glu Phe Glu Glu His His 
    370                 375                 380                 


Lys Val Val Pro Lys Ser His Pro Ile Phe Gln Glu Phe Arg Ile Trp 
385                 390                 395                 400 


Gln Asn Leu Asn Asn Leu Thr Leu Ile Lys Lys Asp Asn Leu Asn Glu 
                405                 410                 415     


Lys Cys Glu Leu Ala Leu Glu Asp Lys Thr Ala Leu Ala Asn Glu Leu 
            420                 425                 430         


Ala Phe Lys Lys Glu Leu Ser Val Lys Asp Ala Leu Lys Val Leu Gly 
        435                 440                 445             


Leu Lys Pro Ser Asp Trp Glu Phe Asn Phe Thr Lys Ile Glu Gly Asn 
    450                 455                 460                 


Arg Thr Asn His Ala Phe Phe Glu Ala Phe Ala Lys Ile Ile Glu Leu 
465                 470                 475                 480 


Glu Asp Gly Glu Pro Ile Asp Leu Gly Asn Leu Lys Ala Asp Asp Ile 
                485                 490                 495     


Leu Asp Gln Phe Ser Glu Ala Phe Leu Arg Ile Gly Ile Asp Thr Glu 
            500                 505                 510         


Leu Leu Gln Val Asn Ser Asp Ile Glu Gly Ala Glu Tyr Glu Lys Gln 
        515                 520                 525             


Ser Tyr Ile Gln Phe Trp His Leu Leu Tyr Ser Ser Glu Asp Asp Gln 
    530                 535                 540                 


Lys Leu Lys Gln Asn Leu Ile Arg Lys Phe Gly Phe Lys Pro Glu His 
545                 550                 555                 560 


Ala Lys Ile Leu Ala Ser Ile Ser Leu Gln Asp Asp His Ala Ser Leu 
                565                 570                 575     


Ser Ser Arg Ala Ile Lys Lys Ile Leu Pro His Leu Gln Ser Gly Leu 
            580                 585                 590         


Ile Tyr Asp Lys Ala Cys Thr Tyr Ala Gly Tyr Asn His Ser Ser Ser 
        595                 600                 605             


Phe Thr Lys Asp Glu Asn Glu Lys Arg Glu Leu Arg Ala Glu Leu Glu 
    610                 615                 620                 


Leu Leu Lys Lys Asn Ser Leu Arg Asn Pro Val Val Glu Lys Ile Leu 
625                 630                 635                 640 


Asn Gln Met Ile Asn Val Val Asn Ala Ile Leu Lys Asp Pro Asn Leu 
                645                 650                 655     


Gly Arg Pro Asp Glu Ile Arg Val Glu Met Ala Arg Glu Leu Lys Ala 
            660                 665                 670         


Asn Ala Glu Gln Arg Lys Asn Met Thr Ser Asn Ile Ala Ser Ala Thr 
        675                 680                 685             


Arg Asp His Glu Lys Tyr Arg Glu Ile Leu Lys Lys Glu Phe Gly Leu 
    690                 695                 700                 


Lys Arg Val Thr Lys Asn Asp Leu Leu Arg Tyr Lys Leu Trp Leu Glu 
705                 710                 715                 720 


Thr Asp Gly Ile Ser Leu Tyr Thr Gly Lys Pro Ile Glu Ala Ser Lys 
                725                 730                 735     


Leu Phe Ser Lys Glu Tyr Asp Ile Glu His Ile Ile Pro Lys Ala Arg 
            740                 745                 750         


Leu Phe Asp Asp Ser Phe Ser Asn Lys Thr Ile Cys Glu Arg Gln Leu 
        755                 760                 765             


Asn Ile Asp Lys Ala Asn Val Thr Ala Phe Ser Phe Leu Gln Asn Lys 
    770                 775                 780                 


Leu Ser Ala Asp Glu Phe Glu Gln Tyr Gln Ser Arg Val Lys Ser Leu 
785                 790                 795                 800 


Tyr Gly Lys Leu Ser Lys Ala Lys Ile Gln Lys Leu Leu Met Ala Asn 
                805                 810                 815     


Asp Lys Ile Pro Glu Asp Phe Ile Ala Arg Gln Leu Gln Glu Thr Arg 
            820                 825                 830         


Tyr Ile Ser Lys Lys Ala Lys Glu Ile Leu Phe Glu Ile Thr Met Arg 
        835                 840                 845             


Val Ser Val Thr Thr Gly Thr Ile Thr Asp Lys Leu Arg Glu Asp Trp 
    850                 855                 860                 


Gly Leu Val Glu Ile Met Lys Glu Leu Asn Trp Glu Lys Tyr Asp Lys 
865                 870                 875                 880 


Leu Gly Leu Thr Tyr Thr Ile Glu Gly Lys His Gly Glu Arg Leu Asn 
                885                 890                 895     


Lys Ile Lys Asp Trp Asn Lys Arg Asn Asp His Arg His His Ala Met 
            900                 905                 910         


Asp Ala Leu Thr Val Ala Leu Thr Lys Pro Ala Tyr Ile Gln Tyr Leu 
        915                 920                 925             


Asn Asn Leu Asn Ala Lys Ala Ile Gly Asn Lys Lys Gly Thr Glu Ile 
    930                 935                 940                 


Phe Ala Ile Glu Gln Lys Tyr Leu Lys Arg Glu Asn Gly Lys Leu Cys 
945                 950                 955                 960 


Phe Ile Pro Pro Ile Glu Asn Ile Arg Ala Glu Ala Lys Lys His Leu 
                965                 970                 975     


Ser Lys Ile Leu Val Ser Tyr Lys Ala Lys Asn Lys Val Val Thr Ile 
            980                 985                 990         


Asn Lys Asn Lys Thr Lys Lys Lys  Ala Gly Phe Asn Glu  Gln Thr Ala 
        995                 1000                 1005             


Leu Thr  Pro Arg Gly Gln Leu  His Lys Glu Thr Val  Tyr Gly Lys 
    1010                 1015                 1020             


Ser Phe  His Tyr Ser Thr Lys  Phe Glu Lys Ile Gly  Ala Ser Phe 
    1025                 1030                 1035             


Asp Ala  Gln Lys Ile Asn Thr  Val Ala Lys Lys Glu  Glu Arg Glu 
    1040                 1045                 1050             


Ala Leu  Leu Lys Arg Leu Ala  Glu Asn Gly Asn Asp  Pro Lys Lys 
    1055                 1060                 1065             


Ala Phe  Thr Gly Lys Asn Ser  Leu Asn Lys Met Pro  Ile Tyr Leu 
    1070                 1075                 1080             


Asp Leu  Gly Lys Asn Ile Lys  Leu Ser Glu Lys Val  Lys Thr Val 
    1085                 1090                 1095             


Val Leu  Glu Gln Asn Tyr Thr  Ile Arg Lys Asn Ile  Asp Pro Asp 
    1100                 1105                 1110             


Leu Lys  Val Asp Lys Val Ile  Asp Val Gly Ile Lys  Arg Ile Leu 
    1115                 1120                 1125             


Glu Ser  Arg Leu Glu Glu Phe  Gly Gly Asn Ala Lys  Leu Ala Phe 
    1130                 1135                 1140             


Ser Asn  Leu Glu Glu Asn Pro  Ile Trp Leu Asn Lys  Glu Lys Gly 
    1145                 1150                 1155             


Ile Pro  Ile Lys Arg Val Lys  Ile Ser Gly Val Ser  Asn Val Glu 
    1160                 1165                 1170             


Ser Leu  His Val Lys Lys Asp  His Phe Gly Glu Lys  Ile Leu Asp 
    1175                 1180                 1185             


Glu Glu  Gly Asn Glu Ile Pro  Val Asp Phe Val Ser  Thr Gly Asn 
    1190                 1195                 1200             


Asn His  His Val Ala Ile Tyr  Glu Asp Glu Asp Gly  Asn Leu Gln 
    1205                 1210                 1215             


Asp Glu  Val Val Asn Phe Tyr  Glu Ala Val Ile Arg  Arg Asn Gln 
    1220                 1225                 1230             


Gly Glu  Ser Ile Ile Lys Tyr  Arg His Glu Glu Gly  Trp Asn Phe 
    1235                 1240                 1245             


Leu Tyr  Ser Ile Lys Gln Asn  Glu Phe Phe Val Phe  Pro Ser Gln 
    1250                 1255                 1260             


Asp Phe  Asn Pro Asn Asp Phe  Asp Leu Leu Asp Pro  Lys Asn Tyr 
    1265                 1270                 1275             


Asp Leu  Ile Ser Pro Asn Leu  Tyr Arg Ala Gln Lys  Phe Ser Lys 
    1280                 1285                 1290             


Val Met  Tyr Gly Asn Ser Ala  Val Arg Asp Tyr Val  Phe Arg His 
    1295                 1300                 1305             


His Leu  Glu Thr Val Leu Asn  Asp Val Lys Glu Leu  Lys Asp Val 
    1310                 1315                 1320             


Ala Tyr  Lys Gln Leu Lys Ser  Leu Gln Tyr Leu Asn  Gly Ile Lys 
    1325                 1330                 1335             


Lys Val  Arg Leu Asn His Leu  Gly Gln Ile Ile Gln  Val Gly Glu 
    1340                 1345                 1350             


Tyr 
    


<210> 261
<211> 1397
<212> PRT
<213> Joostella marina


<220>
<223> Joostella marina DSM 19592

<400> 261
Met Lys Lys Val Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Asn Glu Ala Thr Lys Glu Glu Lys Lys Glu Gly Lys Ser 
            20                  25                  30          


Ser Glu Ile Ile Lys Leu Gly Val Arg Val Asn Pro Leu Thr Val Asp 
        35                  40                  45              


Glu Lys Thr Asn Phe Glu Lys Gly Arg Pro Leu Ser Thr Asn Ala Asp 
    50                  55                  60                  


Arg Thr Leu Lys Arg Ser Ala Arg Arg Asn Leu Gln Arg Tyr Lys Leu 
65                  70                  75                  80  


Arg Arg Arg Asn Leu Ile Glu Ile Leu Ile Lys Asn Gly Phe Ile Thr 
                85                  90                  95      


Lys Asp Thr Pro Leu Thr Glu Thr Gly Lys Asp Thr Thr His Gln Thr 
            100                 105                 110         


Leu Lys Leu Arg Ala Lys Ser Ala Lys Glu Lys Val Asp Leu Lys Asp 
        115                 120                 125             


Phe Ala Lys Ile Leu Leu Thr Ile Asn Lys Lys Arg Gly Tyr Lys Ser 
    130                 135                 140                 


Ser Arg Lys Val Asn Ser Asp Glu Asp Gly Leu Ala Ile Asp Gly Met 
145                 150                 155                 160 


Ala Val Ala Lys His Leu Tyr Glu Gln Asn Leu Thr Pro Gly Gln Tyr 
                165                 170                 175     


Val Leu Asn Leu Leu Gln Lys Asn Lys Lys Tyr Val Pro Asp Phe Tyr 
            180                 185                 190         


Arg Ser Asp Leu Gln Glu Glu Phe Lys Asn Ile Trp Asn Asn Gln Lys 
        195                 200                 205             


Thr Tyr Tyr Phe Asp Ile Leu Thr Asp Thr Leu Phe Glu Glu Leu Lys 
    210                 215                 220                 


Asp Lys Asn Lys Ser Gln Thr Trp Ala Ile Cys Lys Lys Pro Phe Asp 
225                 230                 235                 240 


Ile Ala Gly Ile Lys Gln Ile Gly Lys Ala Ser Asp Lys Arg Leu Glu 
                245                 250                 255     


Arg Tyr Lys Trp Arg Thr Glu Gly Leu Thr Gln Lys Leu Asn Leu Glu 
            260                 265                 270         


Tyr Leu Ala Ile Ala Leu Gln Glu Ile Asn Asn Asp Ile Asn Lys Ser 
        275                 280                 285             


Ser Gly Tyr Leu Gly Ala Ile Ser Asp Arg Ser Lys Glu Leu Phe Phe 
    290                 295                 300                 


Asn Lys Glu Thr Val Gly Glu Asn Leu Tyr Arg Gln Leu Val Lys Thr 
305                 310                 315                 320 


Pro His Thr Ser Leu Arg Asn Gln Val Phe Tyr Arg Gln Asp Tyr Leu 
                325                 330                 335     


Asp Glu Phe Glu Thr Ile Trp Glu Thr Gln Ala Lys Phe Tyr Pro Gln 
            340                 345                 350         


Leu Thr His Thr Leu Lys Glu Glu Ile Arg Asp Val Ile Ile Phe Tyr 
        355                 360                 365             


Gln Arg Lys Leu Lys Ser Gln Lys Ser Leu Ile Ser Phe Cys Gln Phe 
    370                 375                 380                 


Glu Ser Trp Glu Gln Thr Tyr Ile Glu Lys Glu Thr Gly Lys Ser Lys 
385                 390                 395                 400 


Thr Arg Thr Val Gly Arg Lys Val Ile Pro Lys Ser Ser Pro Leu Phe 
                405                 410                 415     


Gln Glu Phe Lys Ile Trp Gln Asn Leu Asn Ser Leu Glu Phe Arg Asn 
            420                 425                 430         


Ser Asp Glu Gly Glu Ile Ile Glu Phe Ile Lys Leu Asp Glu Asp Ile 
        435                 440                 445             


Arg Gln Thr Val Phe Glu Glu Leu Asn Leu Arg Gly Asn Leu Lys Pro 
    450                 455                 460                 


Asn Asp Val Leu Lys Ile Leu Gly Asn Tyr Ile Ser Leu Gly Lys Val 
465                 470                 475                 480 


Ser Gln Trp Lys Cys Asn Phe Glu Glu Ile Glu Gly Asn Arg Thr Asn 
                485                 490                 495     


Ala Ala Leu Tyr Asn Val Tyr Gln Ile Ile Ala Glu Asn Glu Gly Tyr 
            500                 505                 510         


Gly Phe Asp Trp Ala Lys Lys Thr Ala Ser Glu Ile Asn Lys Glu Leu 
        515                 520                 525             


Lys Asn Ile Phe Pro Gln Leu Gly Ile Asp Ala Ser Ile Leu Asp Phe 
    530                 535                 540                 


Asp Phe Thr Gln Ala Asn Phe Asp Lys Gln Thr Ser Tyr Gln Leu Trp 
545                 550                 555                 560 


His Leu Leu Tyr Ser Ala Glu Glu Asp Phe Lys Ile Ser Glu Glu Asp 
                565                 570                 575     


Lys Val Leu Tyr Gly Asn Ser Ser Val Ser Leu Lys Lys Lys Leu His 
            580                 585                 590         


Gln Lys Tyr Gly Phe Lys Pro Glu Tyr Thr Lys Leu Leu Thr Asn Ile 
        595                 600                 605             


Ser Leu Gln Pro Asp Tyr Gly Asn Leu Ser Ala Lys Ala Ile Cys Asn 
    610                 615                 620                 


Ile Leu Pro Tyr Leu Lys Glu Asn Asn Val Tyr Ser Glu Ala Cys Asp 
625                 630                 635                 640 


Leu Thr Gly Tyr Asn His Ser Asn Phe Leu Thr Ala Glu Glu Gln Ala 
                645                 650                 655     


Lys Arg Pro Leu Lys Pro Ile Leu Glu Leu Leu Lys Lys Asn Ser Leu 
            660                 665                 670         


Arg Asn Pro Val Val Glu Lys Ile Leu Asn Gln Met Val Asn Val Val 
        675                 680                 685             


Asn Gln Val Ile Glu Thr Tyr Gly Lys Pro Asp Glu Ile Arg Ile Glu 
    690                 695                 700                 


Leu Thr Arg Glu Leu Lys Lys Ser Ala Lys Glu Arg Ala Asn Met Thr 
705                 710                 715                 720 


Lys Ser Ile Ala Asp Ala Thr Arg Arg Asn Asp Asp Tyr Arg Lys Thr 
                725                 730                 735     


Ile Ile Lys Glu Phe Gly Ile Pro Asn Pro Thr Lys Ser Asp Val Val 
            740                 745                 750         


Arg Tyr Arg Leu Trp Gln Glu Leu Ala Ser Arg Gly Tyr Lys Asp Ile 
        755                 760                 765             


Phe Thr Asp Thr Glu Ile Lys Pro Gln Glu Leu Phe Ser Asn Lys Ile 
    770                 775                 780                 


Asp Ile Glu His Ile Ile Pro Lys Ala Leu Leu Phe Asp Asp Ser Phe 
785                 790                 795                 800 


Ser Asn Lys Thr Leu Ala Phe Lys Lys Asp Asn Leu Lys Lys Ala Asn 
                805                 810                 815     


Arg Thr Ala Tyr Asp Phe Ile Ala Asn Asp Tyr Ala Pro Asn Leu Glu 
            820                 825                 830         


Asn Tyr Ile Glu Arg Val Glu Ser Leu His Lys Asp Arg Lys Ile Thr 
        835                 840                 845             


Arg Ala Lys Arg Asn Lys Leu Leu Met Leu Gln Ser Lys Leu Pro Asp 
    850                 855                 860                 


Gly Phe Ile Glu Arg Asp Leu Arg Asn Ser Gln Tyr Ile Thr Lys Glu 
865                 870                 875                 880 


Ala Lys Lys Met Leu Tyr Glu Val Cys Arg Thr Val Val Ser Thr Ser 
                885                 890                 895     


Gly Ser Ile Thr Asp Lys Leu Arg Glu Asp Trp Asp Leu Ile Asn Val 
            900                 905                 910         


Met Lys Glu Leu Asn Phe Pro Lys Tyr Lys Ala Leu Gly Leu Thr Glu 
        915                 920                 925             


Lys Ile Glu Arg Tyr Asp Ile Gly Ala Glu Lys Met Lys Glu Val Glu 
    930                 935                 940                 


Ile Ile Glu Asp Trp Asn Lys Arg Asn Asp His Arg His His Ala Ile 
945                 950                 955                 960 


Asp Ala Leu Thr Val Ala Phe Ser Thr His Ser His Ile Gln Tyr Leu 
                965                 970                 975     


Asn His Leu Asn Ala Arg Arg Asp Glu Gly His Lys Lys His Ala Ala 
            980                 985                 990         


Ile Ile Ala Ile Glu Ser Thr Ile  Thr Glu Lys Glu Gly  Asn Lys Lys 
        995                 1000                 1005             


Arg Arg  Phe Ile Ala Pro Leu  Pro Asn Phe Arg Leu  Gln Ala Lys 
    1010                 1015                 1020             


Glu His  Ile Glu Ser Ile Leu  Val Ser Phe Lys Asn  Lys Asn Lys 
    1025                 1030                 1035             


Val Val  Thr Asn Asn Ile Asn  Lys Thr Lys Arg Ile  Lys Lys Asp 
    1040                 1045                 1050             


Lys Phe  Asn Thr Lys Val Gln  Leu Thr Pro Arg Gly  Gln Leu His 
    1055                 1060                 1065             


Lys Glu  Thr Ile Tyr Gly Lys  Ile Lys Gln Pro Leu  Glu Lys His 
    1070                 1075                 1080             


Ile Lys  Leu Asn Lys Ser Phe  Thr Leu Glu Gln Ala  Lys Leu Ile 
    1085                 1090                 1095             


Ile Asp  Lys Arg Gln Arg Glu  Lys Val Leu Asn His  Leu Glu Lys 
    1100                 1105                 1110             


Tyr Ala  His Asn Ser Asp Ile  Ala Phe Asn Ser Lys  Thr Leu Lys 
    1115                 1120                 1125             


Lys Asn  Pro Leu Leu Ile Ser  Asp Glu Pro Leu Lys  Glu Val Leu 
    1130                 1135                 1140             


Cys Phe  Glu Glu Val Phe Thr  Ile Arg Lys Asp Ile  Ser Tyr Asp 
    1145                 1150                 1155             


Asn Phe  Lys Asn Glu Lys Gln  Leu Asp Lys Val Ile  Asp Glu Lys 
    1160                 1165                 1170             


Val Lys  Gln Ala Leu Lys Glu  Arg Ile Asn Gln Tyr  Asn Gly Asp 
    1175                 1180                 1185             


Phe Arg  Glu Ala Phe Ser Asp  Ile Glu Arg Asn Pro  Ile Trp Leu 
    1190                 1195                 1200             


Asn Lys  Ala Lys Gly Ile Cys  Val Lys Arg Ala Thr  Ile Lys Gly 
    1205                 1210                 1215             


Val Ser  Asn Ala Glu Pro Leu  His Thr Ala Lys Asn  His Leu Gly 
    1220                 1225                 1230             


Glu Glu  Val Leu Thr Glu Asn  Lys Glu Gln Ile Pro  Val Asp Tyr 
    1235                 1240                 1245             


Val Ser  Thr Gly Asn Asn His  His Val Ala Ile Tyr  Glu Asp Glu 
    1250                 1255                 1260             


Asp Gly  Asn Leu Gln Glu Lys  Val Val Ser Phe Tyr  Glu Ala Val 
    1265                 1270                 1275             


Ile Arg  Val Asn Glu Gly Leu  Pro Ile Ile Asp Lys  Glu Tyr Asn 
    1280                 1285                 1290             


Lys Ser  Leu Gly Trp Thr Phe  Lys Phe Thr Met Lys  Gln Asn Glu 
    1295                 1300                 1305             


Met Phe  Val Phe Pro Ser Glu  Asp Phe Asn Pro Thr  Glu Ile Asp 
    1310                 1315                 1320             


Leu Leu  Asp Gln Lys Asn Ala  Ser Leu Ile Ser Pro  Asn Leu Phe 
    1325                 1330                 1335             


Arg Val  Gln Lys Phe Thr Ile  Lys Asp Tyr Phe Phe  Arg His His 
    1340                 1345                 1350             


Leu Glu  Thr Thr Val Glu Asn  Asn Asn Thr Leu Lys  Asn Thr Thr 
    1355                 1360                 1365             


Trp Arg  Arg Glu Gly Leu Ser  Gly Ile Tyr Gly Ile  Ile Lys Ile 
    1370                 1375                 1380             


Arg Leu  Asn His Leu Gly Glu  Ile Val Gln Val Gly  Glu Tyr 
    1385                 1390                 1395         


<210> 262
<211> 1060
<212> PRT
<213> Kingella kingae


<220>
<223> Kingella kingae PYKK081

<400> 262
Met Ala Ala Lys Ser Leu Asn Tyr Ile Leu Gly Leu Asp Leu Gly Ile 
1               5                   10                  15      


Ala Ser Cys Gly Trp Ala Val Val Glu Met Asp Glu Gln Glu Asn Pro 
            20                  25                  30          


Leu Arg Leu Ile Asp Val Gly Val Arg Thr Phe Glu Glu Ala Glu Asn 
        35                  40                  45              


Pro Lys Asp Gly Ser Ser Leu Ala Glu Thr Arg Arg Leu Ala Arg Ala 
    50                  55                  60                  


Gln Arg Arg Leu Ile Ser Arg Arg Ala Asn Arg Met Asn Lys Leu Cys 
65                  70                  75                  80  


Arg Leu Leu Lys Gln Glu Asn Val Leu Gln Ala Asn Asp Tyr Asp Glu 
                85                  90                  95      


Lys Gly Leu Ile Ile Gly Leu Pro Asn Gln Ala Trp Glu Leu Arg Ala 
            100                 105                 110         


Gln Gly Leu Asp Arg Lys Leu Glu Pro Lys Glu Trp Ala Ala Val Leu 
        115                 120                 125             


Ile His Leu Val Lys His Arg Gly Tyr Leu Ser Gln Arg Lys Asn Glu 
    130                 135                 140                 


Ser Gln Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Ser Gly Met Asn 
145                 150                 155                 160 


His Asn His Gln Leu Leu Gln Ser Gln Ser Asn Gln Tyr Arg Thr Pro 
                165                 170                 175     


Ala Glu Leu Ala Ile Lys Gln Phe Ala Thr Gln Asp Gly His Ile Arg 
            180                 185                 190         


Asn Gln Arg Gly Ala Tyr Thr His Thr Phe Asn Arg Leu Asp Leu Gln 
        195                 200                 205             


Asn Glu Leu Asn Gln Leu Phe Asp Ala Gln Thr Arg Leu Gly Asn Pro 
    210                 215                 220                 


His Val Ser Gly Ser Leu Lys Thr Ala Ile Asn Asp Leu Leu Met Asn 
225                 230                 235                 240 


Gln Lys Ala Ala Leu Ser Gly Asp Ala Ile Leu Glu Met Leu Gly Arg 
                245                 250                 255     


Cys Thr Phe Glu Pro Ser Glu Tyr Lys Ala Ala Lys Asn Thr Tyr Ser 
            260                 265                 270         


Ala Glu Arg Phe Val Trp Leu Gly Lys Leu Thr Asn Leu Arg Ile Gln 
        275                 280                 285             


Asp Asn Gly Leu Glu Ser Ala Leu Ser Arg Glu Gln Arg Glu Leu Leu 
    290                 295                 300                 


Leu Asn Glu Pro Tyr Asn Lys Thr Lys Leu Thr Tyr Gln Gln Val Arg 
305                 310                 315                 320 


Lys Leu Leu Arg Leu Pro Glu Thr Ala Phe Phe Lys Gly Leu Arg Tyr 
                325                 330                 335     


Gly Lys Asp Asn Ala Glu Ser Ala Thr Phe Met Glu Met Lys Ser Tyr 
            340                 345                 350         


His Ala Ile Arg Lys Ser Leu Glu Asn Lys Ser Leu Lys Ser Glu Trp 
        355                 360                 365             


Glu Lys Leu Lys Thr Gln Pro Lys Leu Leu Asp Leu Ile Gly Thr Ala 
    370                 375                 380                 


Phe Ser Ile Tyr Lys Thr Asp Asp Glu Ile Ala Gly Cys Leu Lys Asn 
385                 390                 395                 400 


Gln Leu Pro Glu Asn Val Ile Ile Ala Leu Gln Gly Gln Leu Asn Phe 
                405                 410                 415     


Ser Asn Phe Met Glu Leu Ser Leu Lys Ala Leu Glu Lys Leu Leu Pro 
            420                 425                 430         


Leu Met Glu Gln Gly Leu Arg Tyr Asp Glu Ala Cys Thr Gln Ile Tyr 
        435                 440                 445             


Gly Asn Arg His Glu Lys Ile Ala Asp Lys Thr Glu Lys Phe Leu Pro 
    450                 455                 460                 


Asn Ile Pro Ala Asp Lys Leu Arg Asn Pro Val Val Leu Arg Thr Leu 
465                 470                 475                 480 


Thr Gln Ala Arg Lys Val Ile Asn Ala Ile Ile Arg Arg Tyr Gly Ser 
                485                 490                 495     


Pro Ala Arg Val His Ile Glu Thr Gly Arg Glu Val Gly Lys Ser Phe 
            500                 505                 510         


Ser Asp Arg Asp Lys Leu Lys Lys Gln Gln Glu Glu Asn Gln Glu Gln 
        515                 520                 525             


Arg Arg Arg Ala Ile Asp Glu Trp Lys Gln Phe Phe Pro Asn Ala Ala 
    530                 535                 540                 


His Glu Pro Lys Ala Val Asp Ile Leu Lys Leu Arg Leu Tyr Gln Leu 
545                 550                 555                 560 


Gln Gln Gly Lys Cys Leu Tyr Ser Gly Leu Pro Ile Asp Val Arg Arg 
                565                 570                 575     


Leu Pro Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe Ser 
            580                 585                 590         


Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Ile Leu Val Leu Ala Ser 
        595                 600                 605             


Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Leu Arg Gly 
    610                 615                 620                 


Ala Asp Asn Ser Glu Ser Trp Arg Leu Phe Val Glu Asn Val Gln Asn 
625                 630                 635                 640 


Cys Gln Phe Ser Pro Asn Lys Lys Gln Lys Ile Met Ala Lys Gln Leu 
                645                 650                 655     


Asp Glu Lys Gly Phe Leu Glu Arg Asn Leu Asn Asp Thr Arg Tyr Val 
            660                 665                 670         


Ser Arg Phe Leu Cys Gln Phe Ile Ser Glu His Leu His Leu Thr Gly 
        675                 680                 685             


Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Ala Leu 
    690                 695                 700                 


Leu Arg Gly Arg Trp Gly Leu Ser Lys Asn Arg Glu Glu Asn Asp Arg 
705                 710                 715                 720 


His His Ala Val Asp Ala Val Val Val Ala Cys Ser Thr Val Ala Met 
                725                 730                 735     


Gln Gln Lys Ile Thr Gln Phe Val Arg Tyr Gln Lys Gly Asn Val Phe 
            740                 745                 750         


Thr Gly Glu Arg Ile Asp Lys Glu Thr Gly Glu Val Ile Ser Ile His 
        755                 760                 765             


Phe Pro Thr Pro Trp Glu His Phe Arg Glu Glu Val Met Ile Arg Val 
    770                 775                 780                 


Phe Asp Asp Asn Pro Leu Arg Thr Leu Pro Glu Lys Leu Pro Asn Arg 
785                 790                 795                 800 


Pro Glu Ala Leu His Glu Tyr Val Met Pro Leu Phe Val Ser Arg Met 
                805                 810                 815     


Pro Thr Arg Lys Met Thr Gly Gln Gly His Lys Glu Thr Ile Lys Ser 
            820                 825                 830         


Ala Lys Arg Leu Asp Glu Lys Ile Ser Val Leu Arg Val Pro Leu Thr 
        835                 840                 845             


Gln Leu Lys Leu Asn Asp Leu Glu Asn Met Val Asn Arg Glu Arg Glu 
    850                 855                 860                 


Pro Ala Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Gln Phe Lys Asn 
865                 870                 875                 880 


Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Phe Lys Gln Gly Gly Gln 
                885                 890                 895     


Gln Val Lys Ala Val Arg Val Glu Ile Val Gln Lys Ser Gly Met Leu 
            900                 905                 910         


Leu Arg Lys Ile Asn Gly Val Ala Asp Asn Gly Ser Met Val Arg Val 
        915                 920                 925             


Asp Val Phe Glu Lys Ser Gly Lys Phe Tyr Leu Val Pro Ile Tyr Ala 
    930                 935                 940                 


Trp Gln Val Ala Glu Gly Ile Leu Pro Asn Tyr Ala Val Val Ala His 
945                 950                 955                 960 


Lys Asp Glu Ser Asp Trp Ile Leu Met Asp Glu Ser Tyr His Phe Lys 
                965                 970                 975     


Phe Ala Leu Tyr Lys Asn Asp Leu Leu Glu Val Gln Thr Lys Lys Gly 
            980                 985                 990         


Gly Ile Met Gly Tyr Phe Ala Ser  Leu Asp Arg Ala Thr  Gly Ala Ile 
        995                 1000                 1005             


Thr Ile  Arg Glu His Asp Arg  Asp Lys Lys Lys Cys  Lys Asp Gly 
    1010                 1015                 1020             


Glu His  Arg Ser Ile Gly Val  Lys Met Ala Ser Ser  Phe Lys Lys 
    1025                 1030                 1035             


Leu Gln  Val Asp Glu Leu Gly  Lys Asn Ile His Glu  Thr Arg Ser 
    1040                 1045                 1050             


Arg Lys  Arg Pro Asn Ile Gly  
    1055                 1060 


<210> 263
<211> 1391
<212> PRT
<213> Kordia algicida


<220>
<223> Kordia algicida OT-1

<400> 263
Met Lys Lys Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Asn Glu Ala Glu His Glu His Glu Gln Ser Ser Ile Val 
            20                  25                  30          


Lys Leu Gly Val Arg Val Asn Pro Leu Ser Val Asp Glu Lys Thr Asn 
        35                  40                  45              


Phe Glu Lys Gly Arg Pro Leu Ser Ile Asn Ala Asp Arg Thr Ser Lys 
    50                  55                  60                  


Arg Ser Ala Arg Arg Asn Leu Gln Arg Phe Lys Leu Arg Arg Lys Asn 
65                  70                  75                  80  


Leu Ile Asn Leu Leu Leu Lys His His Ile Ile Ser Asn Glu Thr Ile 
                85                  90                  95      


Leu Thr Glu Val Gly Lys Asn Thr Thr His Gln Thr Leu Lys Leu Arg 
            100                 105                 110         


Ser Lys Ala Thr Gln Glu Lys Ile Ser Leu Glu Glu Phe Ala Arg Ile 
        115                 120                 125             


Leu Leu Ser Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Glu 
    130                 135                 140                 


Lys Asn Glu Asp Glu Gly Phe Thr Ile Asp Gly Met Ala Ile Ala Lys 
145                 150                 155                 160 


Glu Leu Tyr Asp Asn Gln Leu Thr Pro Gly Gln Tyr Val Tyr Asn Ile 
                165                 170                 175     


Leu Gln Asp Gly Lys Asn Tyr Ile Pro Asp Phe Tyr Arg Ser Asp Leu 
            180                 185                 190         


Gln Ala Glu Phe Asp Asp Val Trp Gln Phe Gln Lys Lys Phe Tyr Ser 
        195                 200                 205             


Ser Ile Leu Thr Asp Glu Phe Tyr Leu Lys Leu Lys Gly Gln Gly Lys 
    210                 215                 220                 


Glu Asn Thr Arg Lys Leu Phe Leu Ala Ile His Gln Val Tyr Thr Ala 
225                 230                 235                 240 


Glu Asn Lys Gly Lys Arg Asp Ala Val Lys Leu Gln Tyr Tyr Lys Trp 
                245                 250                 255     


Arg Ser Glu Ala Val Lys Lys Gln Leu Ser Ile Glu Glu Val Ala Tyr 
            260                 265                 270         


Val Leu Val Glu Ile Asn Asn Asn Ile Asn Lys Ser Ser Gly Tyr Leu 
        275                 280                 285             


Gly Ala Ile Ser Asp Arg Ser Lys Ala Leu Tyr Phe Asn Asn Glu Thr 
    290                 295                 300                 


Val Gly Glu Tyr Leu Tyr Gly Gln Leu Val Lys Asn Arg His Asn Ser 
305                 310                 315                 320 


Leu Arg Asn Gln Val Phe Tyr Arg Gln Asp Tyr Leu Asp Glu Phe Glu 
                325                 330                 335     


Lys Ile Trp Glu Thr Gln Ala Lys Phe Tyr Asp Glu Leu Thr Asn Glu 
            340                 345                 350         


Leu Lys Gln Glu Ile Arg Asp Val Val Ile Phe Tyr Gln Arg Lys Leu 
        355                 360                 365             


Lys Ser Gln Lys His Leu Ile Ser Asp Cys Leu Phe Glu Lys His His 
    370                 375                 380                 


Lys Ala Ile Pro Lys Ser Ser Pro Leu Phe Gln Glu Phe Lys Ile Trp 
385                 390                 395                 400 


Gln Asn Leu Asn Tyr Leu Glu Phe Val His Thr Gln Ser Lys Glu Lys 
                405                 410                 415     


Ile Phe Phe Ser Glu Leu Asp Asp Glu Thr Arg Gln Phe Val Phe Ala 
            420                 425                 430         


Glu Leu Asn Ile Arg Gly Thr Leu Lys Ile Lys Glu Ile Lys Lys Leu 
        435                 440                 445             


Ile Gly Leu Glu Thr Pro Val Tyr Trp Lys Ser Asn Phe Asp Glu Ile 
    450                 455                 460                 


Glu Gly Asn Arg Thr Asn Gln Val Leu Tyr Asn Val Tyr Gln Asn Ile 
465                 470                 475                 480 


Ala Asp Asp Leu Gly Tyr Gly Phe Asp Trp Ser Lys Lys His Ala Phe 
                485                 490                 495     


Glu Ile Asn Ala Glu Leu Gln Ala Ile Phe Lys Asp Val Gly Ile Asp 
            500                 505                 510         


Thr Ala Ile Leu Asn Phe Asp Ala Ser Ile Glu Glu Asn Asp Phe Asp 
        515                 520                 525             


Lys Gln Lys Ser Tyr Gln Leu Trp His Leu Leu Tyr Ser Ala Glu Asp 
    530                 535                 540                 


Thr Asp Lys Ala Thr Glu Glu Asp Lys Leu Ile Tyr Gly Asn Ile Asn 
545                 550                 555                 560 


Thr Lys Leu Lys Lys Gln Leu His Gln Lys Tyr Gly Phe Glu Ala Lys 
                565                 570                 575     


Tyr Gly Asn Leu Leu Ala Asn Ile Ser Leu Gln Gln Asp Tyr Gly Asn 
            580                 585                 590         


Leu Ser Ala Lys Ala Ile Lys Lys Ile Leu Pro Tyr Leu Glu Ser Gly 
        595                 600                 605             


Asn Ser Phe Tyr Glu Ala Cys Thr Ile Val Gly Tyr Asn Pro Ser Asn 
    610                 615                 620                 


Ser Leu Thr Lys Glu Gln Gln Gln Asn Arg Lys Leu Lys Asp Lys Leu 
625                 630                 635                 640 


Glu Leu Leu Pro Lys Asn Ser Leu Arg Asn Pro Val Val Glu Lys Ile 
                645                 650                 655     


Leu Asn Gln Lys Val Asn Leu Ile Asn Gln Leu Ile Asp Glu Tyr Gly 
            660                 665                 670         


Lys Pro Asp Glu Val Arg Ile Glu Leu Ala Arg Glu Leu Lys Lys Ser 
        675                 680                 685             


Ala Lys Gln Arg Ala Asp Leu Ser Lys His Ile Asn Asp Ala Thr Leu 
    690                 695                 700                 


Lys Asn Gln Asn Ile Arg Lys Thr Leu Gln Lys Asp Phe Gly Ile Gln 
705                 710                 715                 720 


Asn Pro Ser Lys Asn Asp Val Ile Arg Tyr Lys Leu Tyr Asp Glu Leu 
                725                 730                 735     


Lys Asp Asn Gly Tyr Lys Thr Leu Phe Thr Asn Lys Tyr Ile Pro Lys 
            740                 745                 750         


Glu Gln Leu Phe Ser Lys Asp Val Asp Ile Glu His Ile Ile Pro Lys 
        755                 760                 765             


Ala Ile Leu Phe Asp Asp Ser Phe Ser Asn Lys Thr Leu Ala Tyr Arg 
    770                 775                 780                 


Asn Val Asn Leu Ala Lys Ala Asp Ala Thr Ala Phe Asp Phe Ile Ser 
785                 790                 795                 800 


Ser Lys His Leu Asp Asp Leu Asp Asn Tyr Lys Ala Arg Val Glu Thr 
                805                 810                 815     


Leu Phe Gln Ser Lys Arg Ile Ser Lys Gly Lys Tyr Lys Lys Leu Leu 
            820                 825                 830         


Met Thr Arg Gln Asn Leu Pro Glu Asp Phe Ile Glu Arg Asp Leu Arg 
        835                 840                 845             


Asn Ser Gln Tyr Ile Ala Lys Lys Ala Thr Ala Met Leu Lys Glu Val 
    850                 855                 860                 


Phe Arg Ser Val Val Pro Thr Ser Gly Arg Ile Thr Asp Lys Leu Arg 
865                 870                 875                 880 


Glu Asp Trp Asp Leu Val Asn Val Met Lys Glu Leu Asn Leu Pro Lys 
                885                 890                 895     


Tyr Arg Thr Leu Gly Leu Thr Glu Phe Ile Glu Arg Lys Asn Gly Asn 
            900                 905                 910         


Lys Ile Glu Gln Ile Ile Asp Trp Thr Lys Arg Asn Asp His Arg His 
        915                 920                 925             


His Ala Met Asp Ala Leu Thr Val Ala Phe Thr Thr His Asn His Ile 
    930                 935                 940                 


Gln Tyr Leu Asn Asn Leu Asn Val Thr His Gly Leu Asn Gly Val Asp 
945                 950                 955                 960 


Thr Asp His Glu Lys Ser Arg Leu Tyr Ala Ile Lys Gln Ala Ile Thr 
                965                 970                 975     


Lys Val Tyr Ile Val Gly Lys Thr Lys Lys Arg Lys Phe Ile Pro Pro 
            980                 985                 990         


Met Glu Asn Phe Arg Ser His Ala  Lys Asn His Leu Glu  Gly Ile Leu 
        995                 1000                 1005             


Ile Ser  Phe Lys Asn Lys Asn  Lys Val Val Thr Lys  Asn Lys Asn 
    1010                 1015                 1020             


Arg Thr  Lys Thr Lys Thr Lys  Gly Val Phe Asn Glu  Lys Ile Gln 
    1025                 1030                 1035             


Leu Thr  Pro Arg Gly Gln Leu  His Lys Glu Thr Ile  Tyr Gly His 
    1040                 1045                 1050             


Ala Lys  Lys Val Ile Val Thr  Lys Glu Lys Val Ser  Ser Lys Phe 
    1055                 1060                 1065             


Thr His  Glu Lys Ile Leu Gln  Val Thr Lys Pro Ala  Tyr Arg Glu 
    1070                 1075                 1080             


Ala Leu  Leu Lys Arg Leu Ala  Ser Phe Lys Asn Asp  Pro Lys Lys 
    1085                 1090                 1095             


Ala Phe  Ser Gly Lys Asn Ala  Leu Ser Lys Asn Pro  Leu Tyr Phe 
    1100                 1105                 1110             


Asp Ile  Thr Ser Gly Lys Lys  Val Pro Asp Thr Val  Lys Leu Ser 
    1115                 1120                 1125             


Tyr Phe  Glu Asn Ser Tyr Val  Ile Arg Lys Glu Val  Asn Ser Asp 
    1130                 1135                 1140             


Asn Phe  Lys Asn Glu Lys Ser  Leu Gln Lys Val Leu  Asp Val Gly 
    1145                 1150                 1155             


Ile Arg  Arg Ile Leu Glu Lys  Arg Leu Ala Asp Tyr  Asn Gly Asn 
    1160                 1165                 1170             


Ala Lys  Glu Ala Phe Ser Asn  Leu Glu Lys Asn Pro  Ile Trp Lys 
    1175                 1180                 1185             


Asp Lys  Glu Lys Gly Val Cys  Ile Lys Lys Val Arg  Ile Glu Ala 
    1190                 1195                 1200             


Leu Lys  Asn Ala Glu Pro Leu  His Val Lys Lys Asp  His Leu Gly 
    1205                 1210                 1215             


Lys Ile  Ile Leu Asp Asp Glu  Asn Lys Ser Thr Pro  Val Asp Phe 
    1220                 1225                 1230             


Ile Ser  Thr Gly Asn Asn His  His Val Ala Ile Tyr  Glu Asp Lys 
    1235                 1240                 1245             


Asp Gly  Lys Leu His Asp Lys  Val Val Ser Phe Tyr  Glu Val Val 
    1250                 1255                 1260             


Ser Arg  Val Asn Leu Gly Leu  Pro Ile Ile Asp Lys  Ser Phe Asn 
    1265                 1270                 1275             


Ser His  Leu Asp Trp Lys Phe  Leu Phe Ser Met Lys  Gln Asn Glu 
    1280                 1285                 1290             


Met Phe  Val Phe Pro Ser Glu  Asp Phe Asn Pro Lys  Glu Ile Asp 
    1295                 1300                 1305             


Ile Gly  Asn Pro Lys Asn Asn  Glu Leu Ile Ser Lys  Tyr Leu Phe 
    1310                 1315                 1320             


Arg Val  Gln Lys Phe Ser Lys  Val Thr Tyr Gly Asn  Ser Ala Val 
    1325                 1330                 1335             


Arg Asp  Tyr Val Phe Arg His  His Leu Glu Thr Glu  Leu Ile Asp 
    1340                 1345                 1350             


Lys Lys  Glu Leu Lys Gly Ile  Thr Tyr Tyr Gln Leu  Lys Ser Ile 
    1355                 1360                 1365             


Gly Met  Leu Glu Lys Leu Val  Lys Val Arg Ile Asn  His Ile Gly 
    1370                 1375                 1380             


Lys Ile  Val His Ile Gly Glu  Tyr 
    1385                 1390     


<210> 264
<211> 1314
<212> PRT
<213> Lactobacillus animalis


<220>
<223> Lactobacillus animalis KCTC 3501

<400> 264
Met Leu Lys Lys Asp Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly His Ala Val Val Thr Asp Asp Tyr Lys Val Pro Thr Lys Lys 
            20                  25                  30          


Met Lys Val Phe Gly Asp Thr Ser Lys Lys Thr Ile Lys Lys Asn Met 
        35                  40                  45              


Leu Gly Val Leu Leu Phe Asn Glu Gly Gln Thr Ala Ala Asp Thr Arg 
    50                  55                  60                  


Leu Lys Arg Gly Thr Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ala Pro Glu Leu Ala Lys Val Asp Pro 
                85                  90                  95      


Asn Phe Leu Tyr Arg Leu Glu Glu Ser Ser Leu Val Ala Glu Asp Lys 
            100                 105                 110         


Lys Tyr Asp Val Tyr Pro Ile Phe Gly Lys Arg Glu Glu Glu Leu Leu 
        115                 120                 125             


Tyr His Asp Thr Tyr Lys Thr Ile Tyr His Leu Arg Ser Ala Leu Ala 
    130                 135                 140                 


Asn Asn Asp Gln Pro Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Ile Ile Lys Tyr Arg Gly Asn Phe Leu Leu Glu Gly Glu Ile Asp 
                165                 170                 175     


Leu Arg Thr Thr Asp Ile Asn Lys Val Phe Ala Glu Phe Ser Glu Thr 
            180                 185                 190         


Leu Asn Glu Asn Ser Asp Glu Asn Leu Gly Lys Leu Asp Val Ala Asp 
        195                 200                 205             


Ile Phe Lys Asn Asn Thr Phe Ser Lys Thr Lys Lys Ser Glu Glu Leu 
    210                 215                 220                 


Leu Lys Leu Ser Gly Ala Lys Lys Asn Gln Leu Ala His Gln Leu Phe 
225                 230                 235                 240 


Lys Met Met Val Gly Asn Met Gly Ser Phe Lys Lys Val Leu Gly Thr 
                245                 250                 255     


Asp Glu Glu His Lys Leu Ser Phe Gly Lys Asp Thr Tyr Glu Asp Asp 
            260                 265                 270         


Leu Asn Asp Leu Leu Ala Glu Ala Gly Asp Gln Tyr Leu Asp Ile Phe 
        275                 280                 285             


Val Ala Ala Lys Lys Val Tyr Asp Ala Ala Ile Leu Ala Ser Ile Leu 
    290                 295                 300                 


Asp Val Lys Asp Thr Gln Thr Lys Thr Val Phe Ser Gln Ala Met Ile 
305                 310                 315                 320 


Glu Arg Tyr Glu Glu His Gln Lys Asp Leu Ile Glu Leu Lys Arg Val 
                325                 330                 335     


Phe Lys Lys Tyr Leu Pro Glu Lys Cys His Asp Phe Phe Ser Glu Pro 
            340                 345                 350         


Lys Ile Ser Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Val Ser Glu Glu 
        355                 360                 365             


Asp Phe Tyr Lys Tyr Thr Lys Lys Thr Leu Lys Gly Ile Pro Glu Thr 
    370                 375                 380                 


Glu Glu Ile Leu Gln Lys Ile Asp Ala Asn Asn Tyr Leu Arg Lys Gln 
385                 390                 395                 400 


Arg Thr Phe Asp Asn Gly Ala Ile Pro His Gln Val His Leu Lys Glu 
                405                 410                 415     


Leu Val Ala Ile Val Glu Asn Gln Gly Lys Tyr Tyr Pro Phe Leu Arg 
            420                 425                 430         


Glu Asn Lys Asp Lys Phe Glu Lys Ile Leu Asn Phe Arg Ile Pro Tyr 
        435                 440                 445             


Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Lys Phe Ala Trp Leu Thr 
    450                 455                 460                 


Arg Ala Gly Glu Gly Lys Ile Thr Pro Tyr Asn Phe Asp Glu Met Ile 
465                 470                 475                 480 


Asp Lys Glu Thr Ser Ala Glu Asp Phe Ile Lys His Met Thr Ile Asn 
                485                 490                 495     


Asp Leu Tyr Leu Pro Thr Glu Pro Val Leu Pro Lys His Ser Leu Leu 
            500                 505                 510         


Tyr Glu Arg Tyr Thr Ile Phe Asn Glu Leu Ala Gly Val Arg Tyr Val 
        515                 520                 525             


Thr Glu Asn Gly Glu Ala Lys Tyr Phe Asp Ala Gln Thr Lys Arg Ser 
    530                 535                 540                 


Ile Phe Glu Leu Phe Lys Leu Asp Arg Lys Val Ser Glu Lys Met Val 
545                 550                 555                 560 


Ile Lys His Leu Lys Val Val Met Pro Ala Ile Arg Ile Gln Ala Leu 
                565                 570                 575     


Lys Gly Leu Asp Asn Gly Lys Phe Asn Ala Ser Tyr Gly Thr Tyr Lys 
            580                 585                 590         


Asp Leu Val Asp Met Gly Val Ala Pro Glu Leu Leu Asn Asp Glu Val 
        595                 600                 605             


Asn Ser Glu Lys Trp Glu Asp Ile Ile Lys Thr Leu Thr Ile Phe Glu 
    610                 615                 620                 


Gly Arg Lys Leu Ile Lys Arg Arg Leu Glu Asn Tyr Arg Asp Phe Leu 
625                 630                 635                 640 


Gly Glu Asp Ile Leu Arg Lys Leu Ser Arg Lys Lys Tyr Thr Gly Trp 
                645                 650                 655     


Gly Arg Leu Ser Ala Lys Leu Leu Asp Gly Ile Tyr Asp Lys Lys Thr 
            660                 665                 670         


His Lys Thr Ile Leu Asp Cys Leu Met Thr Glu Asp Tyr Ser Gln Asn 
        675                 680                 685             


Phe Met Gln Leu Ile Asn Asp Asp Asn Tyr Ser Phe Lys Glu Thr Ile 
    690                 695                 700                 


Lys Asn Ala Gln Val Ile Glu Lys Glu Glu Thr Leu Ala Lys Thr Val 
705                 710                 715                 720 


Gln Glu Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Ser 
                725                 730                 735     


Leu Glu Ile Val Asp Glu Ile Ile Lys Val Met Gly Tyr Lys Pro Lys 
            740                 745                 750         


Ser Ile Val Val Glu Met Ala Arg Glu Thr Gln Lys Thr His Gly Thr 
        755                 760                 765             


Arg Lys Arg Glu Asp Arg Val Gln Gln Ile Val Glu Asn Leu Lys Asp 
    770                 775                 780                 


Ala Asn Glu Leu Pro Glu Lys Leu Pro Ser Asn Ala Glu Leu Ser Asp 
785                 790                 795                 800 


Glu Arg Lys Tyr Leu Tyr Cys Leu Gln Asn Gly Arg Asp Met Tyr Thr 
                805                 810                 815     


Gly Ala Pro Leu Asp Tyr Asp His Leu Gln Phe Tyr Asp Val Asp His 
            820                 825                 830         


Ile Ile Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Glu Asn Lys Val 
        835                 840                 845             


Leu Thr Ile Lys Lys Glu Asn Val Arg Lys Thr Asn Gly Leu Pro Ser 
    850                 855                 860                 


Glu Ala Val Ile Gln Lys Met Gly Ser Phe Trp Lys Lys Leu Leu Asp 
865                 870                 875                 880 


Ala Gly Ala Met Thr Asn Lys Lys Tyr Asp Asn Leu Arg Arg Asn Leu 
                885                 890                 895     


His Gly Gly Leu Asn Glu Lys Leu Lys Glu Arg Phe Ile Glu Arg Gln 
            900                 905                 910         


Leu Val Glu Thr Arg Gln Ile Thr Lys Tyr Val Ala Gln Leu Leu Asp 
        915                 920                 925             


Gln Arg Leu Asn Tyr Asp Gly Asn Gly Val Glu Leu Asp Glu Lys Ile 
    930                 935                 940                 


Ala Ile Val Thr Leu Lys Ala Gln Leu Ala Ser Gln Phe Arg Ser Glu 
945                 950                 955                 960 


Phe Lys Leu Arg Lys Val Arg Ala Leu Asn Asn Leu His His Ala His 
                965                 970                 975     


Asp Ala Tyr Leu Asn Ala Ile Val Ala Asn Leu Ile Met Ala Lys Tyr 
            980                 985                 990         


Pro Glu Leu Glu Pro Glu Phe Val  Tyr Gly Lys Tyr Arg  Lys Ala Lys 
        995                 1000                 1005             


Phe Lys  Gly Leu Gly Lys Ala  Thr Ala Lys Asn Thr  Leu Tyr Ala 
    1010                 1015                 1020             


Asn Val  Leu Tyr Phe Leu Lys  Glu Asn Glu Val Tyr  Pro Phe Trp 
    1025                 1030                 1035             


Asp Lys  Ala Arg Asp Leu Pro  Thr Ile Lys Arg Tyr  Leu Tyr Arg 
    1040                 1045                 1050             


Ala Gln  Val Asn Lys Val Arg  Lys Ala Glu Arg Gln  Ile Gly Gly 
    1055                 1060                 1065             


Phe Ser  Asp Glu Met Leu Val  Pro Lys Ser Asp Ser  Gly Lys Leu 
    1070                 1075                 1080             


Leu Pro  Arg Lys Glu Gly Leu  Asp Pro Val Lys Tyr  Gly Gly Tyr 
    1085                 1090                 1095             


Ala Lys  Ala Val Glu Ser Tyr  Ala Val Leu Ile Thr  Ala Asp Glu 
    1100                 1105                 1110             


Val Lys  Lys Gly Lys Thr Lys  Lys Val Lys Thr Leu  Val Asn Ile 
    1115                 1120                 1125             


Pro Ile  Ile Asp Ser Lys Lys  Tyr Glu Ala Asp Pro  Thr Ala Tyr 
    1130                 1135                 1140             


Leu Ala  Ser Arg Gly Tyr Thr  Asn Val Thr Asn Ser  Phe Ile Leu 
    1145                 1150                 1155             


Pro Lys  Tyr Ser Leu Leu Glu  Asp Pro Glu Gly Arg  Arg Arg Tyr 
    1160                 1165                 1170             


Leu Ala  Ser Phe Lys Glu Phe  Gln Lys Ala Asn Glu  Leu Ile Leu 
    1175                 1180                 1185             


Pro Gln  His Leu Val Glu Leu  Leu Tyr Trp Val Asn  Ala Lys Asp 
    1190                 1195                 1200             


Gly Glu  Gln Lys Leu Glu Asp  His Lys Ala Glu Phe  Lys Glu Leu 
    1205                 1210                 1215             


Phe Asp  Lys Ile Met Glu Phe  Ala Asp Lys Tyr Val  Val Ala Pro 
    1220                 1225                 1230             


Lys Asn  Ser Glu Lys Ile Arg  Arg Leu Tyr Glu Glu  Asn Gln Asp 
    1235                 1240                 1245             


Ala Thr  Pro Met Glu Leu Gly  Lys Asn Phe Val Glu  Leu Leu Arg 
    1250                 1255                 1260             


Tyr Thr  Ala Asp Gly Ala Ala  Ser Asp Phe Lys Phe  Phe Gly Glu 
    1265                 1270                 1275             


Asn Ile  Pro Arg Lys Arg Tyr  Asn Ser Ala Gly Ser  Leu Leu Asn 
    1280                 1285                 1290             


Gly Thr  Leu Ile Tyr Gln Ser  Lys Thr Gly Leu Tyr  Glu Thr Arg 
    1295                 1300                 1305             


Ile Asp  Leu Gly Lys Leu 
    1310                 


<210> 265
<211> 1377
<212> PRT
<213> Lactobacillus brevis


<220>
<223> Lactobacillus brevis subsp. gravesensis ATCC 27305

<400> 265
Met Glu Ser Asn His Asp Gly Glu Gln Val Lys Tyr Thr Leu Gly Leu 
1               5                   10                  15      


Asp Ile Gly Thr Ser Ser Ile Gly Tyr Ala Ala Ile Asp Lys His Gln 
            20                  25                  30          


Lys Pro Ile Arg Ala Lys Gly Lys His Val Ile Gly Val Arg Leu Phe 
        35                  40                  45              


Gln Glu Gly Gln Thr Ala Ala Asp Arg Arg Ala Phe Arg Thr Thr Arg 
    50                  55                  60                  


Arg Arg Leu Lys Arg Arg Lys Trp Arg Leu Asn Leu Leu Asn Arg Leu 
65                  70                  75                  80  


Phe Asp Pro Tyr Leu Ser Glu Val Asp Pro Asn Phe Leu Pro Arg Leu 
                85                  90                  95      


Arg Gln Ser Asn Leu Ser Pro Lys Asp Asp Asn Lys His Phe Asn Gly 
            100                 105                 110         


Ser Thr Leu Phe Pro Asp Lys Thr Asp Ala Ala Phe Tyr Arg Gln Tyr 
        115                 120                 125             


Pro Thr Met Tyr His Leu Arg Tyr Ala Leu Met Thr Glu Lys Arg Lys 
    130                 135                 140                 


Phe Asp Ile Arg Glu Val Tyr Leu Ala Ile His His Ile Val Lys Tyr 
145                 150                 155                 160 


Arg Gly Asn Phe Leu Asn Ser Ala Thr Val Asp Ser Phe Lys Thr Ser 
                165                 170                 175     


Asn Ile Asp Phe Thr Ser Gln Phe Asp Arg Leu Asn Glu Leu Tyr Arg 
            180                 185                 190         


Gln Val Ile Leu Asp Glu Pro Phe Gln Ile Asn Met Asp Gln Val Asp 
        195                 200                 205             


Glu Met Thr Asn Lys Leu Leu Asp Asn Asp Ala Leu Lys Leu Asp Thr 
    210                 215                 220                 


Gln Lys Gln Val Ala Lys Leu Leu Pro Val Ile Tyr Asn Asp Lys Pro 
225                 230                 235                 240 


Ile Asp Lys Gln Tyr Thr Arg Ile Ala Thr Glu Phe Ser Lys Ala Ile 
                245                 250                 255     


Leu Gly Tyr Lys Thr Lys Leu Asp Val Ile Leu Asn Leu Asp Thr Gln 
            260                 265                 270         


Asn Ala Lys Asp Trp Val Ile Arg Leu Asp Asp Glu Asp Ile Asp Asp 
        275                 280                 285             


Lys Leu Pro Ala Leu Val Glu Asn Leu Asp Glu Ser Arg Gln Glu Ile 
    290                 295                 300                 


Val Thr Ile Ile Arg Asp Leu Tyr Ala Gln Ile Thr Leu Asn Ala Ile 
305                 310                 315                 320 


Val Pro Lys Gly Lys Ser Leu Ser Glu Ser Met Val Asp Lys Tyr Asn 
                325                 330                 335     


Asp His Lys Asp His Leu Asp Leu Leu Met Gly Leu Ile His Glu Leu 
            340                 345                 350         


Gly Asp Asp Ser Ala Lys Gly Ile Lys Leu Arg Glu Ala Tyr Thr Gln 
        355                 360                 365             


Tyr Val Gly Lys Ser Asp Asp Lys Thr Leu Asn Gln Asp Asp Phe Tyr 
    370                 375                 380                 


Ala Ala Ile Lys Lys Asn Leu Asp Glu Asp Ser Lys Arg Ser Pro Lys 
385                 390                 395                 400 


Ile Gln Arg Leu Ile Glu Gln Ala Ser Phe Met Pro Lys Gln Arg Thr 
                405                 410                 415     


Ser Ala Asn Gly Val Ile Pro His Gln Leu His Gln Leu Glu Leu Asp 
            420                 425                 430         


Arg Ile Ile Glu Asn Gln Gly Arg Tyr Tyr Pro Phe Leu Lys Lys Pro 
        435                 440                 445             


Asn Pro Asn Thr His Lys Pro Asn Gly Gly Lys Tyr Lys Leu Asp Glu 
    450                 455                 460                 


Leu Val Ala Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ile Thr Lys 
465                 470                 475                 480 


Arg Asp Gln Glu Lys Thr Ser Gly Ala Asp Phe Ala Trp Met Ile Arg 
                485                 490                 495     


Lys Pro Gly Gln Glu Gly Glu Ile Thr Pro Trp Asn Phe Asp Gln Lys 
            500                 505                 510         


Val Asp Arg Met Ala Ser Ala Asn Arg Phe Ile Arg Arg Met Thr Thr 
        515                 520                 525             


Lys Asp Ser Tyr Leu Val Ala Glu Asp Val Leu Pro Asp Ala Ser Leu 
    530                 535                 540                 


Ile Tyr Glu Lys Phe Lys Ala Leu Asn Glu Leu Asn Met Leu Lys Val 
545                 550                 555                 560 


Asn Asp Ser Arg Leu Ser Pro Ser Gln Lys Gln Asp Leu Phe Asn Asn 
                565                 570                 575     


Leu Phe Lys Lys Gln Lys Thr Ile Arg Thr Lys Lys Leu Gln Thr Tyr 
            580                 585                 590         


Ile Arg Thr Asn Trp Glu Leu Pro Ser Val Met Ile Ser Gly Leu Ala 
        595                 600                 605             


Asp Pro Asp Lys Phe Asn Ser Ser Leu Ser Thr Tyr Ile Asp Phe Arg 
    610                 615                 620                 


Asp Ile Phe Gly Glu Lys Val Asp Asp Pro Asn Arg Gln Ala Asp Tyr 
625                 630                 635                 640 


Glu Glu Ile Ile Glu Trp Ser Thr Val Phe Glu Asp Arg Lys Ile Tyr 
                645                 650                 655     


Gln Ala Lys Leu Asn Gln Leu Asp Trp Leu Thr Glu Pro Gln Arg Lys 
            660                 665                 670         


Ala Leu Leu Thr Lys Arg Tyr Thr Gly Trp Gly Arg Leu Ser Lys Lys 
        675                 680                 685             


Leu Leu Thr Gly Leu Lys Asp Gln Asn Gly Asp Ser Ile Leu Asp Gln 
    690                 695                 700                 


Leu Trp Lys Thr Asn Asp Asn Phe Met Gln Ile Gln Ser Arg Asp Glu 
705                 710                 715                 720 


Phe Ala Lys Gln Ile His Asp Glu Asn Ala Lys Gln Phe His Glu Ala 
                725                 730                 735     


Asn Asn Val Asp Asp Ile Leu Asp Asp Ala Phe Thr Ser Pro Gln Asn 
            740                 745                 750         


Lys Lys Ala Ile Arg Gln Val Asp Lys Val Val Gln Asp Val Val Lys 
        755                 760                 765             


Ala Val Gly Tyr Ala Pro Asp Lys Ile Ala Ile Glu Phe Thr Arg Ser 
    770                 775                 780                 


Leu Glu Asn Asn Pro Gln Arg Thr Val Ser Arg Gln Arg Gln Leu Gln 
785                 790                 795                 800 


Ala Ala Tyr Lys Asn Ile Pro Arg Glu Ile Met Lys Ser Gly Leu Met 
                805                 810                 815     


Ala Glu Leu Gly Ser Val Ala Asp Ser Lys Lys Val Leu Ser Asp Lys 
            820                 825                 830         


Leu Tyr Leu Tyr Phe Thr Gln Met Gly Lys Asp Met Tyr Glu Asp Lys 
        835                 840                 845             


Thr Ile Asn Ile Asp Asn Leu Pro Asn Tyr Asp Ile Asp His Ile Leu 
    850                 855                 860                 


Pro Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Ile 
865                 870                 875                 880 


Ser Lys Glu Glu Asn Ala Arg Lys Ser Asn Arg Val Pro Leu Lys Phe 
                885                 890                 895     


Phe Gly Ala Lys Arg Met Gly Phe Trp Lys Asp Leu Leu Asn Asn Gly 
            900                 905                 910         


Leu Ile Ser Asn Arg Lys Phe Gln Asn Leu Thr Thr Asp Pro Glu Lys 
        915                 920                 925             


Ile Ser Lys Tyr Ser Ala Lys Gly Phe Ile His Arg Gln Leu Val Glu 
    930                 935                 940                 


Thr Ser Gln Val Ile Arg Leu Val Ala Asn Ile Leu Gly Asn Glu Tyr 
945                 950                 955                 960 


Ser Gln Ala Gly Thr Thr Ile Ile Glu Val Ser Ala Lys Met Asn Arg 
                965                 970                 975     


Gln Leu Arg Glu Asp Phe His Leu Ile Lys Asn Arg Asn Val Asn Asp 
            980                 985                 990         


Tyr His His Ala Met Asp Ala Tyr  Leu Thr Ala Tyr Val  Gly Asp Tyr 
        995                 1000                 1005             


Leu Tyr  Leu Arg Tyr Pro Lys  Leu Arg Pro Tyr Phe  Val Tyr Gly 
    1010                 1015                 1020             


Asp Phe  Lys Lys Ala Glu Asp  Gln Asp Leu Asn Ile  Arg Asn Phe 
    1025                 1030                 1035             


Asn Phe  Leu His Asp Leu Lys  Asp Asn Glu Ser Leu  Asp Lys Ile 
    1040                 1045                 1050             


Val Asp  Ser Glu Thr Gly Glu  Ile Val Trp Glu Lys  His Gly Ser 
    1055                 1060                 1065             


Val Lys  Gln Leu Lys Lys Val  Tyr His Tyr Lys Phe  Met Leu Val 
    1070                 1075                 1080             


Ser Gln  Glu Val Tyr Thr Arg  Gln Asp Ala Leu Phe  Asn Gln Thr 
    1085                 1090                 1095             


Ile Tyr  Pro Ala Ser Asp Ala  Asp Lys Arg Lys Leu  Ile Pro Ile 
    1100                 1105                 1110             


Lys Asn  Ser Lys Pro Val Asp  Val Tyr Gly Gly Tyr  Ser Gly Asn 
    1115                 1120                 1125             


Ile Asp  Ala Tyr Met Ala Ile  Val Arg Val His Gly  Lys Lys Glu 
    1130                 1135                 1140             


Asp Asn  Tyr Lys Val Val Gly  Ile Pro Met Arg Ala  Val Thr Lys 
    1145                 1150                 1155             


Leu Lys  Lys Ala Glu Lys Glu  Gly His Asp Ser Tyr  Leu Asn Ala 
    1160                 1165                 1170             


Val His  Glu Val Leu Lys Pro  Gln Phe Thr Lys Lys  Lys Lys Asn 
    1175                 1180                 1185             


Arg Lys  Thr Gly Glu Ile Thr  Glu Thr Val Asp Glu  Phe Asp Val 
    1190                 1195                 1200             


Leu Leu  Gly Lys Val Tyr Tyr  Arg Gln Leu Ile Val  Asp Gly Asn 
    1205                 1210                 1215             


Lys Lys  Phe Met Leu Gly Ser  Ser Ser Tyr Gln Tyr  Asn Ala Lys 
    1220                 1225                 1230             


Gln Leu  Val Leu Ser Asp Lys  Ala Met Gln Val Leu  Ser Lys Asn 
    1235                 1240                 1245             


Gly Lys  Val Lys Ser Gln Asp  Glu Asn Gln Asn Leu  Ile Asp Val 
    1250                 1255                 1260             


Tyr Asp  Glu Ile Leu Glu Lys  Val Asp Gln Tyr Phe  Glu Leu Tyr 
    1265                 1270                 1275             


Asp Gln  Arg His Tyr Arg Glu  Ser Leu His Lys Gly  Arg Gly Ile 
    1280                 1285                 1290             


Phe Val  Asn Leu Pro Leu Ser  Asn Gln Tyr Asp Gly  Ser Lys Leu 
    1295                 1300                 1305             


Thr Ser  Tyr Gly Lys Tyr Glu  Thr Ile Asp Ala Ile  Leu Asn Gly 
    1310                 1315                 1320             


Leu His  Ala Asn Ala Thr Met  Ser Asn Leu Arg Tyr  Leu Gly Ile 
    1325                 1330                 1335             


Ser Ser  Pro Phe Gly Lys Met  Gln Ala Ser Asn Gly  Leu Thr Ile 
    1340                 1345                 1350             


Asp Pro  Asp Ser Ile Ile Cys  Tyr Gln Ser Pro Thr  Gly Leu Phe 
    1355                 1360                 1365             


Glu Arg  Gln Ile Lys Leu Ser  Asp Leu 
    1370                 1375         


<210> 266
<211> 1371
<212> PRT
<213> Lactobacillus buchneri

<400> 266
Met Lys Val Asn Asn Tyr His Ile Gly Leu Asp Ile Gly Thr Ser Ser 
1               5                   10                  15      


Ile Gly Trp Val Ala Ile Gly Lys Asp Gly Lys Pro Leu Arg Val Lys 
            20                  25                  30          


Gly Lys Thr Ala Ile Gly Ala Arg Leu Phe Gln Glu Gly Asn Pro Ala 
        35                  40                  45              


Ala Asp Arg Arg Met Phe Arg Thr Thr Arg Arg Arg Leu Ser Arg Arg 
    50                  55                  60                  


Lys Trp Arg Leu Lys Leu Leu Glu Glu Ile Phe Asp Pro Tyr Ile Thr 
65                  70                  75                  80  


Pro Val Asp Ser Thr Phe Phe Ala Arg Leu Lys Gln Ser Asn Leu Ser 
                85                  90                  95      


Pro Lys Asp Ser Arg Lys Glu Phe Lys Gly Ser Met Leu Phe Pro Asp 
            100                 105                 110         


Leu Thr Asp Met Gln Tyr His Lys Asn Tyr Pro Thr Ile Tyr His Leu 
        115                 120                 125             


Arg His Ala Leu Met Thr Gln Asp Lys Lys Phe Asp Ile Arg Met Val 
    130                 135                 140                 


Tyr Leu Ala Ile His His Ile Val Lys Tyr Arg Gly Asn Phe Leu Asn 
145                 150                 155                 160 


Ser Thr Pro Val Asp Ser Phe Lys Ala Ser Lys Val Asp Phe Val Asp 
                165                 170                 175     


Gln Phe Lys Lys Leu Asn Glu Leu Tyr Ala Ala Ile Asn Pro Glu Glu 
            180                 185                 190         


Ser Phe Lys Ile Asn Leu Ala Asn Ser Glu Asp Ile Gly His Gln Phe 
        195                 200                 205             


Leu Asp Pro Ser Ile Arg Lys Phe Asp Lys Lys Lys Gln Ile Pro Lys 
    210                 215                 220                 


Ile Val Pro Val Met Met Asn Asp Lys Val Thr Asp Arg Leu Asn Gly 
225                 230                 235                 240 


Lys Ile Ala Ser Glu Ile Ile His Ala Ile Leu Gly Tyr Lys Ala Lys 
                245                 250                 255     


Leu Asp Val Val Leu Gln Cys Thr Pro Val Asp Ser Lys Pro Trp Ala 
            260                 265                 270         


Leu Lys Phe Asp Asp Glu Asp Ile Asp Ala Lys Leu Glu Lys Ile Leu 
        275                 280                 285             


Pro Glu Met Asp Glu Asn Gln Gln Ser Ile Val Ala Ile Leu Gln Asn 
    290                 295                 300                 


Leu Tyr Ser Gln Val Thr Leu Asn Gln Ile Val Pro Asn Gly Met Ser 
305                 310                 315                 320 


Leu Ser Glu Ser Met Ile Glu Lys Tyr Asn Asp His His Asp His Leu 
                325                 330                 335     


Lys Leu Tyr Lys Lys Leu Ile Asp Gln Leu Ala Asp Pro Lys Lys Lys 
            340                 345                 350         


Ala Val Leu Lys Lys Ala Tyr Ser Gln Tyr Val Gly Asp Asp Gly Lys 
        355                 360                 365             


Val Ile Glu Gln Ala Glu Phe Trp Ser Ser Val Lys Lys Asn Leu Asp 
    370                 375                 380                 


Asp Ser Glu Leu Ser Lys Gln Ile Met Asp Leu Ile Asp Ala Glu Lys 
385                 390                 395                 400 


Phe Met Pro Lys Gln Arg Thr Ser Gln Asn Gly Val Ile Pro His Gln 
                405                 410                 415     


Leu His Gln Arg Glu Leu Asp Glu Ile Ile Glu His Gln Ser Lys Tyr 
            420                 425                 430         


Tyr Pro Trp Leu Val Glu Ile Asn Pro Asn Lys His Asp Leu His Leu 
        435                 440                 445             


Ala Lys Tyr Lys Ile Glu Gln Leu Val Ala Phe Arg Val Pro Tyr Tyr 
    450                 455                 460                 


Val Gly Pro Met Ile Thr Pro Lys Asp Gln Ala Glu Ser Ala Glu Thr 
465                 470                 475                 480 


Val Phe Ser Trp Met Glu Arg Lys Gly Thr Glu Thr Gly Gln Ile Thr 
                485                 490                 495     


Pro Trp Asn Phe Asp Glu Lys Val Asp Arg Lys Ala Ser Ala Asn Arg 
            500                 505                 510         


Phe Ile Lys Arg Met Thr Thr Lys Asp Thr Tyr Leu Ile Gly Glu Asp 
        515                 520                 525             


Val Leu Pro Asp Glu Ser Leu Leu Tyr Glu Lys Phe Lys Val Leu Asn 
    530                 535                 540                 


Glu Leu Asn Met Val Arg Val Asn Gly Lys Leu Leu Lys Val Ala Asp 
545                 550                 555                 560 


Lys Gln Ala Ile Phe Gln Asp Leu Phe Glu Asn Tyr Lys His Val Ser 
                565                 570                 575     


Val Lys Lys Leu Gln Asn Tyr Ile Lys Ala Lys Thr Gly Leu Pro Ser 
            580                 585                 590         


Asp Pro Glu Ile Ser Gly Leu Ser Asp Pro Glu His Phe Asn Asn Ser 
        595                 600                 605             


Leu Gly Thr Tyr Asn Asp Phe Lys Lys Leu Phe Gly Ser Lys Val Asp 
    610                 615                 620                 


Glu Pro Asp Leu Gln Asp Asp Phe Glu Lys Ile Val Glu Trp Ser Thr 
625                 630                 635                 640 


Val Phe Glu Asp Lys Lys Ile Leu Arg Glu Lys Leu Asn Glu Ile Thr 
                645                 650                 655     


Trp Leu Ser Asp Gln Gln Lys Asp Val Leu Glu Ser Ser Arg Tyr Gln 
            660                 665                 670         


Gly Trp Gly Arg Leu Ser Lys Lys Leu Leu Thr Gly Ile Val Asn Asp 
        675                 680                 685             


Gln Gly Glu Arg Ile Ile Asp Lys Leu Trp Asn Thr Asn Lys Asn Phe 
    690                 695                 700                 


Met Gln Ile Gln Ser Asp Asp Asp Phe Ala Lys Arg Ile His Glu Ala 
705                 710                 715                 720 


Asn Ala Asp Gln Met Gln Ala Val Asp Val Glu Asp Val Leu Ala Asp 
                725                 730                 735     


Ala Tyr Thr Ser Pro Gln Asn Lys Lys Ala Ile Arg Gln Val Val Lys 
            740                 745                 750         


Val Val Asp Asp Ile Gln Lys Ala Met Gly Gly Val Ala Pro Lys Tyr 
        755                 760                 765             


Ile Ser Ile Glu Phe Thr Arg Ser Glu Asp Arg Asn Pro Arg Arg Thr 
    770                 775                 780                 


Ile Ser Arg Gln Arg Gln Leu Glu Asn Thr Leu Lys Asp Thr Ala Lys 
785                 790                 795                 800 


Ser Leu Ala Lys Ser Ile Asn Pro Glu Leu Leu Ser Glu Leu Asp Asn 
                805                 810                 815     


Ala Ala Lys Ser Lys Lys Gly Leu Thr Asp Arg Leu Tyr Leu Tyr Phe 
            820                 825                 830         


Thr Gln Leu Gly Lys Asp Ile Tyr Thr Gly Glu Pro Ile Asn Ile Asp 
        835                 840                 845             


Glu Leu Asn Lys Tyr Asp Ile Asp His Ile Leu Pro Gln Ala Phe Ile 
    850                 855                 860                 


Lys Asp Asn Ser Leu Asp Asn Arg Val Leu Val Leu Thr Ala Val Asn 
865                 870                 875                 880 


Asn Gly Lys Ser Asp Asn Val Pro Leu Arg Met Phe Gly Ala Lys Met 
                885                 890                 895     


Gly His Phe Trp Lys Gln Leu Ala Glu Ala Gly Leu Ile Ser Lys Arg 
            900                 905                 910         


Lys Leu Lys Asn Leu Gln Thr Asp Pro Asp Thr Ile Ser Lys Tyr Ala 
        915                 920                 925             


Met His Gly Phe Ile Arg Arg Gln Leu Val Glu Thr Ser Gln Val Ile 
    930                 935                 940                 


Lys Leu Val Ala Asn Ile Leu Gly Asp Lys Tyr Arg Asn Asp Asp Thr 
945                 950                 955                 960 


Lys Ile Ile Glu Ile Thr Ala Arg Met Asn His Gln Met Arg Asp Glu 
                965                 970                 975     


Phe Gly Phe Ile Lys Asn Arg Glu Ile Asn Asp Tyr His His Ala Phe 
            980                 985                 990         


Asp Ala Tyr Leu Thr Ala Phe Leu  Gly Arg Tyr Leu Tyr  His Arg Tyr 
        995                 1000                 1005             


Ile Lys  Leu Arg Pro Tyr Phe  Val Tyr Gly Asp Phe  Lys Lys Phe 
    1010                 1015                 1020             


Arg Glu  Asp Lys Val Thr Met  Arg Asn Phe Asn Phe  Leu His Asp 
    1025                 1030                 1035             


Leu Thr  Asp Asp Thr Gln Glu  Lys Ile Ala Asp Ala  Glu Thr Gly 
    1040                 1045                 1050             


Glu Val  Ile Trp Asp Arg Glu  Asn Ser Ile Gln Gln  Leu Lys Asp 
    1055                 1060                 1065             


Val Tyr  His Tyr Lys Phe Met  Leu Ile Ser His Glu  Val Tyr Thr 
    1070                 1075                 1080             


Leu Arg  Gly Ala Met Phe Asn  Gln Thr Val Tyr Pro  Ala Ser Asp 
    1085                 1090                 1095             


Ala Gly  Lys Arg Lys Leu Ile  Pro Val Lys Ala Asp  Arg Pro Val 
    1100                 1105                 1110             


Asn Val  Tyr Gly Gly Tyr Ser  Gly Ser Ala Asp Ala  Tyr Met Ala 
    1115                 1120                 1125             


Ile Val  Arg Ile His Asn Lys  Lys Gly Asp Lys Tyr  Arg Val Val 
    1130                 1135                 1140             


Gly Val  Pro Met Arg Ala Leu  Asp Arg Leu Asp Ala  Ala Lys Asn 
    1145                 1150                 1155             


Val Ser  Asp Ala Asp Phe Asp  Arg Ala Leu Lys Asp  Val Leu Ala 
    1160                 1165                 1170             


Pro Gln  Leu Thr Lys Thr Lys  Lys Ser Arg Lys Thr  Gly Glu Ile 
    1175                 1180                 1185             


Thr Gln  Val Ile Glu Asp Phe  Glu Ile Val Leu Gly  Lys Val Met 
    1190                 1195                 1200             


Tyr Arg  Gln Leu Met Ile Asp  Gly Asp Lys Lys Phe  Met Leu Gly 
    1205                 1210                 1215             


Ser Ser  Thr Tyr Gln Tyr Asn  Ala Lys Gln Leu Val  Leu Ser Asp 
    1220                 1225                 1230             


Gln Ser  Val Lys Thr Leu Ala  Ser Lys Gly Arg Leu  Asp Pro Leu 
    1235                 1240                 1245             


Gln Glu  Ser Met Asp Tyr Asn  Asn Val Tyr Thr Glu  Ile Leu Asp 
    1250                 1255                 1260             


Lys Val  Asn Gln Tyr Phe Ser  Leu Tyr Asp Met Asn  Lys Phe Arg 
    1265                 1270                 1275             


His Lys  Leu Asn Leu Gly Phe  Ser Lys Phe Ile Ser  Phe Pro Asn 
    1280                 1285                 1290             


His Asn  Val Leu Asp Gly Asn  Thr Lys Val Ser Ser  Gly Lys Arg 
    1295                 1300                 1305             


Glu Ile  Leu Gln Glu Ile Leu  Asn Gly Leu His Ala  Asn Pro Thr 
    1310                 1315                 1320             


Phe Gly  Asn Leu Lys Asp Val  Gly Ile Thr Thr Pro  Phe Gly Gln 
    1325                 1330                 1335             


Leu Gln  Gln Pro Asn Gly Ile  Leu Leu Ser Asp Glu  Thr Lys Ile 
    1340                 1345                 1350             


Arg Tyr  Gln Ser Pro Thr Gly  Leu Phe Glu Arg Thr  Val Ser Leu 
    1355                 1360                 1365             


Lys Asp  Leu 
    1370     


<210> 267
<211> 1371
<212> PRT
<213> Lactobacillus buchneri

<400> 267
Met Lys Val Asn Asn Tyr His Ile Gly Leu Asp Ile Gly Thr Ser Ser 
1               5                   10                  15      


Ile Gly Trp Val Ala Ile Gly Glu Asp Gly Lys Pro Leu Arg Ile Lys 
            20                  25                  30          


Gly Lys Thr Ala Ile Gly Ala Arg Leu Phe Gln Glu Gly Asn Pro Ala 
        35                  40                  45              


Ala Asp Arg Arg Met Phe Arg Thr Thr Arg Arg Arg Leu Ser Arg Arg 
    50                  55                  60                  


Lys Trp Arg Leu Lys Leu Leu Glu Glu Ile Phe Asp Pro Tyr Ile Thr 
65                  70                  75                  80  


Pro Val Asp Ser Thr Phe Phe Ala Arg Leu Lys Gln Ser Asn Leu Ser 
                85                  90                  95      


Pro Lys Asp Ser Arg Lys Glu Phe Lys Gly Ser Met Leu Phe Pro Asp 
            100                 105                 110         


Leu Thr Asp Met Gln Tyr His Lys Asp Tyr Pro Thr Ile Tyr His Leu 
        115                 120                 125             


Arg His Ala Leu Met Thr Gln Asp Glu Lys Phe Asp Ile Arg Met Val 
    130                 135                 140                 


Tyr Leu Ala Ile His His Ile Val Lys Tyr Arg Gly Asn Phe Leu Asn 
145                 150                 155                 160 


Ser Thr Pro Val Asp Ser Phe Lys Ala Ser Lys Val Asn Phe Val Asp 
                165                 170                 175     


Gln Phe Lys Lys Leu Asn Glu Leu Tyr Thr Ala Ile Asn Pro Glu Glu 
            180                 185                 190         


Ser Phe Gln Ile Asn Leu Ala Asn Ser Glu Asp Ile Gly His Gln Phe 
        195                 200                 205             


Leu Asp Pro Ser Ile Arg Lys Phe Asp Lys Lys Lys Gln Ile Pro Lys 
    210                 215                 220                 


Ile Val Pro Val Ser Val Asp Asp Lys Ala Thr Asp Lys Ile Asn Gly 
225                 230                 235                 240 


Lys Ile Ala Ser Glu Ile Ile Asn Ala Ile Leu Gly Tyr Lys Ser Lys 
                245                 250                 255     


Leu Asp Val Val Val Gln Cys Thr Pro Val Asp Ser Lys Ser Trp Ala 
            260                 265                 270         


Leu Lys Phe Asp Glu Glu Asp Ile Asp Ala Lys Leu Gln Lys Ile Leu 
        275                 280                 285             


Pro Glu Met Asp Glu Asn Gln Gln Ser Ile Ile Ala Ile Leu Gln Asn 
    290                 295                 300                 


Leu Tyr Ser Gln Val Thr Leu Asn Gln Ile Val Pro Asn Gly Met Ser 
305                 310                 315                 320 


Leu Ser Glu Ser Met Ile Glu Lys Tyr Asn Asp His His Asp His Leu 
                325                 330                 335     


Lys Leu Tyr Lys Lys Ile Ile Asp Gln Leu Ala Asp Pro Lys Lys Lys 
            340                 345                 350         


Ala Ala Leu Lys Lys Ala Tyr Ser Gln Tyr Val Gly Asp Asp Gly Lys 
        355                 360                 365             


Val Ile Glu Gln Ala Asp Phe Trp Ser Ser Val Lys Lys Asn Leu Asp 
    370                 375                 380                 


Asp Ser Asp Leu Ser Lys Gln Ile Met Asp Leu Ile Asp Ala Glu Lys 
385                 390                 395                 400 


Phe Met Pro Lys Gln Arg Thr Ser Gln Asn Gly Val Ile Pro His Gln 
                405                 410                 415     


Leu His Gln Arg Glu Leu Asp Glu Ile Ile Glu His Gln Ser Lys Tyr 
            420                 425                 430         


Tyr Pro Trp Leu Ala Glu Ile Asn Pro Asn Lys His Asp Leu His Leu 
        435                 440                 445             


Ala Lys Tyr Lys Ile Glu Glu Leu Val Ala Phe Arg Val Pro Tyr Tyr 
    450                 455                 460                 


Val Gly Pro Met Ile Thr Pro Asp Asp Gln Ala Lys Ser Ala Glu Thr 
465                 470                 475                 480 


Val Phe Ser Trp Met Glu Arg Lys Gly Lys Glu Ala Gly Gln Ile Thr 
                485                 490                 495     


Pro Trp Asn Phe Asp Glu Lys Val Asp Arg Asn Ala Ser Ala Asn Arg 
            500                 505                 510         


Phe Ile Lys Arg Met Thr Thr Lys Asp Thr Tyr Leu Ile Gly Glu Asp 
        515                 520                 525             


Val Leu Pro Asp Glu Ser Leu Leu Tyr Glu Lys Phe Lys Val Leu Asn 
    530                 535                 540                 


Glu Leu Asn Met Val Arg Val Asn Gly Lys Leu Leu Lys Val Ala Asp 
545                 550                 555                 560 


Lys Gln Ala Ile Phe Gln Asp Leu Phe Glu Asn Tyr Lys His Ile Ser 
                565                 570                 575     


Val Lys Lys Leu Gln Asn Tyr Ile Lys Ser Lys Thr Gly Leu Pro Ser 
            580                 585                 590         


Asp Pro Glu Ile Ser Gly Leu Ser Asp Pro Glu Tyr Phe Asn Asn Ser 
        595                 600                 605             


Leu Gly Thr Tyr Asn Asp Phe Lys Lys Leu Phe Gly Asn Lys Val Asp 
    610                 615                 620                 


Glu Pro Asp Leu Gln Asp Asp Phe Glu Lys Ile Val Glu Trp Ser Thr 
625                 630                 635                 640 


Val Phe Glu Asp Lys Arg Ile Leu Arg Glu Lys Leu Asn Glu Ile Thr 
                645                 650                 655     


Trp Leu Ser Asp Gln Gln Lys Asp Val Leu Glu Ser Ser Arg Tyr Gln 
            660                 665                 670         


Gly Trp Gly Arg Leu Ser Lys Lys Leu Leu Thr Gly Ile Val Asn Asp 
        675                 680                 685             


Gln Gly Glu Arg Ile Ile Asp Glu Leu Trp Asn Thr Asn Lys Asn Phe 
    690                 695                 700                 


Met Gln Ile Gln Ser Asp Asn Asp Phe Ala Lys Arg Ile His Glu Ala 
705                 710                 715                 720 


Asn Ala Asp Gln Met Lys Ala Val Asp Val Glu Asp Val Leu Ala Asp 
                725                 730                 735     


Ala Tyr Thr Ser Pro Gln Asn Lys Lys Ala Ile Arg Gln Val Val Lys 
            740                 745                 750         


Val Val Asp Asp Ile Gln Lys Ala Met Gly Gly Val Ala Pro Lys Tyr 
        755                 760                 765             


Ile Ser Ile Glu Phe Thr Arg Ser Glu Asp Arg Asn Pro Arg Arg Thr 
    770                 775                 780                 


Ile Ser Arg Gln Arg Gln Leu Glu Asn Thr Leu Lys Asp Thr Ala Lys 
785                 790                 795                 800 


Ser Leu Ala Lys Ser Ile Asn Pro Glu Leu Leu Ser Glu Leu Asp Asn 
                805                 810                 815     


Ala Ala Lys Ser Lys Lys Gly Leu Thr Asp Arg Leu Tyr Leu Tyr Phe 
            820                 825                 830         


Thr Gln Leu Gly Lys Asp Ile Tyr Thr Gly Lys Pro Ile Asn Ile Asp 
        835                 840                 845             


Glu Ile Ser Thr Tyr Asp Ile Asp His Ile Leu Pro Gln Ala Phe Val 
    850                 855                 860                 


Lys Asp Asp Ser Leu Asn Asn Arg Val Leu Val Ser Lys Ala Ile Asn 
865                 870                 875                 880 


Asn Gly Lys Ser Asp Asn Val Pro Val Gln Leu Phe Gly Ala Lys Met 
                885                 890                 895     


Gly His Phe Trp Lys Gln Leu Ala Glu Ala Gly Leu Ile Ser Lys Arg 
            900                 905                 910         


Lys Leu Lys Asn Leu Gln Thr Asp Pro Asp Thr Ile Ser Lys Tyr Ala 
        915                 920                 925             


Met His Gly Phe Ile Arg Arg Gln Leu Val Glu Thr Ser Gln Val Ile 
    930                 935                 940                 


Lys Leu Val Ala Asn Ile Leu Gly Asp Lys Tyr Arg Asn Asp Asn Thr 
945                 950                 955                 960 


Lys Ile Ile Glu Ile Thr Ala Arg Met Asn His Gln Met Arg Asp Glu 
                965                 970                 975     


Phe Gly Phe Ile Lys Asn Arg Glu Ile Asn Asp Tyr His His Ala Phe 
            980                 985                 990         


Asp Ala Tyr Leu Thr Ala Phe Leu  Gly Arg Tyr Leu Tyr  His Arg Tyr 
        995                 1000                 1005             


Ile Lys  Leu Arg Pro Tyr Phe  Val Tyr Gly Asp Phe  Lys Lys Phe 
    1010                 1015                 1020             


Lys Glu  Asp Lys Val Thr Met  Arg Asn Phe Asn Phe  Leu His Asp 
    1025                 1030                 1035             


Leu Thr  Asp Asp Thr Gln Glu  Lys Ile Ala Asp Ala  Glu Thr Gly 
    1040                 1045                 1050             


Glu Val  Ile Trp Asp Arg Glu  Asn Ser Ile Gln Gln  Leu Lys Asp 
    1055                 1060                 1065             


Val Tyr  His Tyr Lys Phe Met  Leu Ile Ser His Glu  Val Tyr Thr 
    1070                 1075                 1080             


Leu Arg  Gly Ala Met Phe Asn  Gln Thr Val Tyr Pro  Ala Ser Asp 
    1085                 1090                 1095             


Ala Gly  Lys Arg Lys Leu Ile  Pro Ile Lys Ala Asp  Arg Pro Ile 
    1100                 1105                 1110             


Asn Val  Tyr Gly Gly Tyr Ser  Gly Ser Ala Asp Ala  Tyr Met Ala 
    1115                 1120                 1125             


Ile Val  Arg Ile His Asn Lys  Lys Gly Asp Lys Tyr  Arg Val Val 
    1130                 1135                 1140             


Gly Val  Pro Met Arg Ala Arg  Asp Arg Leu Asp Ala  Ala Lys Lys 
    1145                 1150                 1155             


Val Ser  Asp Ala Asp Cys Asp  Arg Ala Leu Lys Asp  Val Leu Thr 
    1160                 1165                 1170             


Pro Gln  Leu Thr Lys Thr Lys  Lys Ser Arg Lys Thr  Gly Glu Ile 
    1175                 1180                 1185             


Thr Gln  Val Val Glu Asp Phe  Glu Ile Val Leu Gly  Lys Val Met 
    1190                 1195                 1200             


Tyr Arg  Gln Leu Met Ile Asp  Gly Asp Lys Lys Phe  Met Leu Gly 
    1205                 1210                 1215             


Ser Ser  Thr Tyr Gln Tyr Asn  Ala Lys Gln Leu Val  Leu Ser Asp 
    1220                 1225                 1230             


Gln Ser  Val Lys Thr Leu Ala  Ser Lys Gly Arg Leu  Asp Pro Leu 
    1235                 1240                 1245             


Gln Glu  Ser Met Asp Tyr Asn  Asn Val Tyr Thr Glu  Ile Leu Asp 
    1250                 1255                 1260             


Lys Val  Asn Gln Tyr Phe Ser  Leu Tyr Asp Met Asn  Lys Phe Arg 
    1265                 1270                 1275             


His Lys  Leu Asn Leu Gly Phe  Ser Lys Phe Ile Ser  Phe Pro Asn 
    1280                 1285                 1290             


His Asn  Val Phe Asp Gly Asn  Thr Lys Ala Ser Ser  Gly Lys Arg 
    1295                 1300                 1305             


Glu Ile  Leu Glu Glu Val Leu  Asn Gly Leu His Ala  Asn Pro Thr 
    1310                 1315                 1320             


Phe Gly  Asn Leu Lys Asp Ile  Gly Ile Thr Thr Pro  Phe Gly Gln 
    1325                 1330                 1335             


Leu Gln  Gln Pro Asn Gly Ile  Leu Leu Ser Asp Glu  Ala Lys Ile 
    1340                 1345                 1350             


Arg Tyr  Gln Ser Pro Thr Gly  Leu Phe Glu Arg Thr  Val Ser Leu 
    1355                 1360                 1365             


Lys Asp  Leu 
    1370     


<210> 268
<211> 1361
<212> PRT
<213> Lactobacillus casei


<220>
<223> Lactobacillus casei BL23

<400> 268
Met Thr Lys Leu Gly Lys Pro Tyr Gly Ile Gly Val Asp Ile Gly Ser 
1               5                   10                  15      


Asn Ser Ile Gly Phe Ala Ala Val Asp Glu Asn Ser His Leu Ile Arg 
            20                  25                  30          


Leu Lys Gly Lys Thr Val Ile Gly Ala Arg Leu Phe Glu Glu Gly Lys 
        35                  40                  45              


Ala Ala Ala Asp Arg Arg Ala Ser Arg Thr Thr Arg Arg Arg Leu Ser 
    50                  55                  60                  


Arg Asn Arg Trp Arg Leu Ser Phe Leu Arg Asp Phe Phe Glu Ser His 
65                  70                  75                  80  


Ile Thr Pro Thr Gly Pro Asn Phe Phe Met Arg Gln Lys Tyr Ser Glu 
                85                  90                  95      


Ile Ser Pro Lys Asp Lys Ala Arg Tyr Lys Tyr Glu Lys Arg Leu Phe 
            100                 105                 110         


Asn Asp Arg Thr Asp Ala Glu Phe Tyr Gln Gln Tyr Pro Thr Met Tyr 
        115                 120                 125             


His Leu Arg Asn Arg Leu Leu Thr Asp Pro Ser Lys Ala Asp Val Arg 
    130                 135                 140                 


Glu Ile Tyr Phe Ala Ile His His Ile Leu Lys Ser Arg Gly His Phe 
145                 150                 155                 160 


Leu Thr Ser Gly Tyr Ala Lys Asp Phe Asn Thr Asn Lys Val Ala Leu 
                165                 170                 175     


Asn Glu Ile Phe Pro Ala Leu Gln Asp Ala Tyr Ala Gln Val Tyr Pro 
            180                 185                 190         


Asp Leu Asp Ile Thr Phe Asp Glu Asn Lys Val Asn Glu Phe Lys Thr 
        195                 200                 205             


Val Leu Leu Asn Glu Lys Ala Thr Pro Ser Asp Thr Gln Arg Ala Leu 
    210                 215                 220                 


Val Asn Leu Leu Leu Ala Glu Asp Gly Asp Lys Asp Ile Leu Lys Gln 
225                 230                 235                 240 


Gln Lys Gln Val Leu Thr Glu Phe Ala Lys Ala Val Val Gly Leu Lys 
                245                 250                 255     


Thr Lys Leu Asn Val Ala Leu Gly Thr Glu Val Asp Ser Ser Glu Ala 
            260                 265                 270         


Thr Val Trp Asn Phe Ser Leu Gly Gln Leu Asp Asp Lys Trp Ala Gly 
        275                 280                 285             


Ile Glu Ser Ala Met Thr Asp Glu Gly Thr Glu Ile Leu Asp Gln Ile 
    290                 295                 300                 


Arg Asp Leu Tyr Arg Ala Arg Leu Leu Asn Gly Ile Val Pro Ala Gly 
305                 310                 315                 320 


Lys Thr Leu Ser Gln Ala Lys Val Asp Asp Tyr Ala Gln His His Glu 
                325                 330                 335     


Asp Leu Glu Leu Phe Lys Asp Tyr Leu Lys Gln Leu Glu Asp Asp Gly 
            340                 345                 350         


Thr Ala Lys Ala Ile Arg Gln Leu Tyr Asp Arg Tyr Ile Asp Gly Asp 
        355                 360                 365             


Asp Ala Lys Pro Phe Val Arg Glu Asp Phe Val Lys Ala Leu Thr Lys 
    370                 375                 380                 


Glu Val Thr Ala His Pro Asn Ala Lys Ser Pro Glu Leu Leu Glu Arg 
385                 390                 395                 400 


Leu Ala Gln Pro Asp Phe Met Leu Lys Gln Arg Asn Lys Ala Asn Gly 
                405                 410                 415     


Ala Ile Pro Val Gln Met Gln Gln Arg Glu Leu Asp Gln Ile Ile Lys 
            420                 425                 430         


Asn Gln Ser Val Tyr Tyr Asp Trp Leu Ala Ala Pro Asn Pro Val Glu 
        435                 440                 445             


Lys His Arg Lys Ser Met Pro Tyr Gln Leu Asp Glu Leu Leu Asn Phe 
    450                 455                 460                 


Arg Ile Pro Tyr Tyr Val Gly Pro Leu Val Thr Ala Lys Glu Gln Lys 
465                 470                 475                 480 


Ala Ala Gln Gly Gly Val Phe Ala Trp Met Val Arg Lys Asp Pro Asp 
                485                 490                 495     


Gly Asn Ile Thr Pro Tyr Asn Phe Asp Glu Lys Val Asp Arg Glu Ala 
            500                 505                 510         


Ser Ala Asn Thr Phe Ile Gln Arg Met Lys Thr Thr Asp Thr Tyr Leu 
        515                 520                 525             


Ile Gly Glu Asp Val Leu Pro Lys Gln Ser Leu Leu Tyr Gln Arg Tyr 
    530                 535                 540                 


Glu Val Leu Asn Glu Leu Asn Asn Val Arg Val Asn Asn Glu Lys Leu 
545                 550                 555                 560 


Ser Ile Glu Gln Lys Gln Gln Val Ile Arg Glu Leu Phe Glu Arg His 
                565                 570                 575     


Asn Ser Val Thr Ile Lys Gln Phe Ala Glu Asn Leu Arg Ala His Gly 
            580                 585                 590         


Asp Tyr Ala His Ile Pro Glu Ile Arg Gly Leu Ala Asp Glu Lys Arg 
        595                 600                 605             


Phe Leu Ser Ser Leu Ser Thr Tyr Arg Gln Leu Lys Ser Leu Leu Pro 
    610                 615                 620                 


Asp Ala Ile Asp Asp Pro Ala Lys Gln Ala Asp Ile Glu Asn Ile Ile 
625                 630                 635                 640 


Ala Trp Ser Thr Val Phe Glu Asp Ala Ala Ile Phe Lys Thr Lys Leu 
                645                 650                 655     


Lys Glu Ile Asn Trp Leu Asp Ser Gln Thr Ile Thr Lys Leu Ser Asn 
            660                 665                 670         


Ile Arg Tyr Arg Gly Trp Gly Gln Phe Ser His Lys Phe Leu Asn Gly 
        675                 680                 685             


Leu Thr Leu Gly Asn Gly His Thr Ile Ile Gln Glu Leu Phe Leu Ser 
    690                 695                 700                 


Asn Asn Asn Leu Met Gln Ile Leu Thr Asp Glu Thr Leu Gln Lys Lys 
705                 710                 715                 720 


Met Thr Glu Leu Asn Ala Asp Lys Leu Lys Ala Ala Asn Ile Asn Asp 
                725                 730                 735     


Ala Ile Asp Asp Ala Tyr Thr Ser Pro Ser Asn Lys Lys Ala Leu Arg 
            740                 745                 750         


Gln Val Leu Arg Val Ile Glu Asp Ile Lys Arg Ala Ala Asp Gly Gln 
        755                 760                 765             


Asp Pro Ser Trp Leu Tyr Val Glu Thr Ala Asp Gly Gly Gly Thr Pro 
    770                 775                 780                 


Gly Lys Arg Thr Arg Ala Arg Gln His Gln Leu Gln Glu Ile Tyr Ala 
785                 790                 795                 800 


Asn Ala Ala His Glu Leu Ile Asp Ser Ala Val Arg Gly Glu Leu Glu 
                805                 810                 815     


Asp Lys Ile Ala Asp Lys Ala Asp Phe Asn Asp Arg Leu Val Leu Tyr 
            820                 825                 830         


Phe Met Gln Gly Gly Arg Asp Ile Tyr Thr Gly Thr Pro Leu Asn Ile 
        835                 840                 845             


Asp Gln Leu Ser Ser Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Leu 
    850                 855                 860                 


Ile Lys Asp Asn Ser Leu Asp Asn Arg Val Leu Val His Ala Ile Ile 
865                 870                 875                 880 


Asn Arg Glu Lys Asn Ala Thr Phe Ala Ser Thr Ile Tyr Ala Gln Lys 
                885                 890                 895     


Met Asn Ala Thr Trp Arg Gln Trp His Glu Ala Gly Leu Ile Ser Gly 
            900                 905                 910         


Arg Lys Leu Arg Asn Leu Gln Met Arg Pro Asp Gln Ile Asp Lys Tyr 
        915                 920                 925             


Ala Ser Gly Phe Val Ala Arg Gln Leu Val Glu Thr Arg Gln Ile Ile 
    930                 935                 940                 


Lys Leu Thr Glu Gln Ile Val Ala Ala Gln Tyr Pro Glu Thr Lys Ile 
945                 950                 955                 960 


Ile Ala Val Lys Ala Gly Leu Ser His Gln Leu Arg Glu Glu Leu Glu 
                965                 970                 975     


Phe Pro Lys Asn Arg Asp Val Asn His Tyr His His Ala Phe Asp Ala 
            980                 985                 990         


Phe Leu Ala Ala Arg Ile Gly Thr  Tyr Leu Leu Lys Arg  Phe Pro Asn 
        995                 1000                 1005             


Leu Gln  Ala Phe Phe Thr Tyr  Gly Lys Phe Lys Lys  Ala Asp Val 
    1010                 1015                 1020             


Lys Lys  Leu Arg Gly Phe Asn  Phe Ile Arg Asp Ile  Thr His Ala 
    1025                 1030                 1035             


Glu Asp  Lys Ile Val Val Lys  Asp Thr Gly Glu Val  Ile Trp Asp 
    1040                 1045                 1050             


Lys Lys  Arg Asp Val Asp Glu  Leu Asp Arg Ile Tyr  Asn Phe Lys 
    1055                 1060                 1065             


Arg Met  Leu Ile Thr His Glu  Val His Phe Glu Lys  Ala Asp Leu 
    1070                 1075                 1080             


Phe Lys  Gln Thr Val Tyr Gly  Ala Lys Asp Ser Lys  Glu Ala Gly 
    1085                 1090                 1095             


Gly Lys  Lys Gln Leu Ile Ser  Lys Lys Lys Gly Tyr  Pro Val Asp 
    1100                 1105                 1110             


Ile Tyr  Gly Gly Tyr Thr Gln  Glu Thr Gly Ser Tyr  Leu Ser Val 
    1115                 1120                 1125             


Val Arg  Leu Thr Lys Lys Ala  Met Tyr Ala Val Val  Lys Val Ser 
    1130                 1135                 1140             


Thr Arg  Asp Ala Ala Lys Leu  Ala Val Ala Lys Ser  Ile Ser Glu 
    1145                 1150                 1155             


Gln Lys  Glu Asn Glu Thr Leu  Asn Asp Ile Ile Asp  Glu Lys Leu 
    1160                 1165                 1170             


Ser Lys  Ile Ser Lys Asn Gly  Lys Ile Thr His Glu  Leu Phe Glu 
    1175                 1180                 1185             


Val Val  Leu Pro Arg Val Gly  Gln Lys Thr Leu Phe  Lys Asn Ser 
    1190                 1195                 1200             


Lys Tyr  Asn Leu Phe Leu Val  Asn Ser Asp Thr Tyr  Met His Asn 
    1205                 1210                 1215             


Tyr Gln  Glu Leu Trp Met Pro  Arg Glu Tyr Gln Lys  Met Trp Lys 
    1220                 1225                 1230             


Asp Ile  Ser Leu Ser Lys Tyr  Gly Asp Ala Gln Thr  Glu Asp Gln 
    1235                 1240                 1245             


Leu Asp  Gln Ile Phe Gly Phe  Ile Val Ser Gln Val  Asn Ser Tyr 
    1250                 1255                 1260             


Phe Asn  Leu Tyr Asp Ile Asn  Gln Phe Arg Lys Lys  Leu Asn Asp 
    1265                 1270                 1275             


Ala Ala  Asp Lys Phe Ala Thr  Leu Pro Met Arg Asp  Thr Asp Asp 
    1280                 1285                 1290             


Met Gln  Gly Lys Ile Ala Thr  Ile Gly Gln Leu Leu  Ile Gly Leu 
    1295                 1300                 1305             


Gln Ala  Asn Ala Ala Arg Ser  Asp Leu Arg Asn Leu  Asp Ile Lys 
    1310                 1315                 1320             


Thr Pro  Leu Gly Leu Leu Gln  Ile Pro Asn Gly Ile  Ser Leu Asp 
    1325                 1330                 1335             


Ser Asp  Thr Ser Val Val Tyr  Gln Ser Pro Thr Gly  Leu Leu Glu 
    1340                 1345                 1350             


Arg Glu  Val His Leu Ser Asp  Leu 
    1355                 1360     


<210> 269
<211> 1361
<212> PRT
<213> Lactobacillus casei


<220>
<223> Lactobacillus casei Lc-10

<400> 269
Met Thr Lys Leu Gly Lys Pro Tyr Gly Ile Gly Val Asp Ile Gly Ser 
1               5                   10                  15      


Asn Ser Ile Gly Phe Ala Ala Val Asp Glu Asn Ser His Leu Ile Arg 
            20                  25                  30          


Leu Lys Gly Lys Thr Val Ile Gly Ala Arg Leu Phe Glu Glu Gly Lys 
        35                  40                  45              


Ala Ala Ala Asp Arg Arg Ala Ser Arg Thr Thr Arg Arg Arg Leu Ser 
    50                  55                  60                  


Arg Asn Arg Trp Arg Leu Ser Phe Leu Arg Asp Phe Phe Glu Ser His 
65                  70                  75                  80  


Ile Thr Pro Thr Gly Pro Asn Phe Phe Met Arg Gln Lys Tyr Ser Glu 
                85                  90                  95      


Ile Ser Pro Lys Asp Lys Ala Arg Tyr Lys Tyr Glu Lys Arg Leu Phe 
            100                 105                 110         


Asn Asp Arg Thr Asp Ala Glu Phe Tyr Gln Gln Tyr Pro Thr Met Tyr 
        115                 120                 125             


His Leu Arg Asn Arg Leu Leu Thr Asp Pro Ser Lys Ala Asp Val Arg 
    130                 135                 140                 


Glu Ile Tyr Phe Ala Ile His His Ile Leu Lys Ser Arg Gly His Phe 
145                 150                 155                 160 


Leu Thr Ser Gly Tyr Ala Lys Asp Phe Asn Thr Asn Lys Val Ala Leu 
                165                 170                 175     


Asn Glu Ile Phe Pro Ala Leu Gln Asp Ala Tyr Ala Gln Val Tyr Pro 
            180                 185                 190         


Asp Leu Asp Ile Thr Phe Asp Glu Asn Lys Val Asn Glu Phe Lys Thr 
        195                 200                 205             


Val Leu Leu Asn Glu Lys Ala Thr Pro Ser Asp Thr Gln Arg Ala Leu 
    210                 215                 220                 


Val Asn Leu Leu Leu Ala Glu Asp Gly Asp Lys Asp Ile Leu Lys Gln 
225                 230                 235                 240 


Gln Lys Gln Val Leu Thr Glu Phe Ala Lys Ala Val Val Gly Leu Lys 
                245                 250                 255     


Thr Lys Leu Asn Val Ala Leu Gly Thr Glu Val Asp Ser Ser Glu Ala 
            260                 265                 270         


Thr Val Trp Asn Phe Ser Leu Gly Gln Leu Asp Asp Lys Trp Ala Gly 
        275                 280                 285             


Ile Glu Ser Ala Met Thr Asp Glu Gly Thr Glu Ile Leu Asp Gln Ile 
    290                 295                 300                 


Arg Asp Leu Tyr Arg Ala Arg Leu Leu Asn Gly Ile Val Pro Ala Gly 
305                 310                 315                 320 


Asn Thr Leu Ser Gln Ala Lys Val Asp Asp Tyr Ala Gln His His Glu 
                325                 330                 335     


Asp Leu Glu Leu Phe Lys Asp Tyr Leu Lys Gln Leu Glu Asp Asp Gly 
            340                 345                 350         


Thr Ala Lys Ala Ile Arg Gln Leu Tyr Asp Arg Tyr Ile Asp Gly Asp 
        355                 360                 365             


Asp Ala Lys Pro Phe Val Arg Glu Asp Phe Val Lys Ala Leu Thr Lys 
    370                 375                 380                 


Glu Val Thr Ala His Pro Asn Ala Lys Ser Pro Glu Leu Leu Glu Arg 
385                 390                 395                 400 


Leu Ala Gln Pro Asp Phe Met Leu Lys Gln Arg Asn Lys Ala Asn Gly 
                405                 410                 415     


Ala Ile Pro Val Gln Met Gln Gln Arg Glu Leu Asp Gln Ile Ile Lys 
            420                 425                 430         


Asn Gln Ser Val Tyr Tyr Asp Trp Leu Ala Ala Pro Asn Pro Val Glu 
        435                 440                 445             


Lys His Arg Lys Ser Met Pro Tyr Gln Leu Asp Glu Leu Leu Asn Phe 
    450                 455                 460                 


Arg Ile Pro Tyr Tyr Val Gly Pro Leu Val Thr Ala Lys Glu Gln Lys 
465                 470                 475                 480 


Ala Ala Gln Gly Gly Val Phe Ala Trp Met Val Arg Lys Asp Pro Asp 
                485                 490                 495     


Gly Asn Ile Thr Pro Tyr Asn Phe Asp Glu Lys Val Asp Arg Glu Ala 
            500                 505                 510         


Ser Ala Asn Thr Phe Ile Gln Arg Met Lys Thr Thr Asp Thr Tyr Leu 
        515                 520                 525             


Ile Gly Glu Asp Val Leu Pro Lys Gln Ser Leu Leu Tyr Gln Arg Tyr 
    530                 535                 540                 


Glu Val Leu Asn Glu Leu Asn Asn Val Arg Val Asn Asn Glu Lys Leu 
545                 550                 555                 560 


Ser Ile Glu Gln Lys Gln Gln Val Ile Arg Glu Leu Phe Glu Arg His 
                565                 570                 575     


Asn Ser Val Thr Ile Lys Gln Phe Ala Glu Asn Leu Arg Ala His Gly 
            580                 585                 590         


Asp Tyr Ala His Ile Pro Glu Ile Arg Gly Leu Ala Asp Glu Lys Arg 
        595                 600                 605             


Phe Leu Ser Ser Leu Ser Thr Tyr Arg Gln Leu Lys Ser Leu Leu Pro 
    610                 615                 620                 


Asp Ala Ile Asp Asp Pro Ala Lys Gln Ala Asp Ile Glu Asn Ile Ile 
625                 630                 635                 640 


Ala Trp Ser Thr Val Phe Glu Asp Ala Ala Ile Phe Lys Thr Lys Leu 
                645                 650                 655     


Lys Glu Ile Asn Trp Leu Asp Ser Gln Thr Ile Thr Lys Leu Ser Asn 
            660                 665                 670         


Ile Arg Tyr Arg Gly Trp Gly Gln Phe Ser His Lys Phe Leu Asn Gly 
        675                 680                 685             


Leu Thr Leu Gly Asn Gly His Thr Ile Ile Gln Glu Leu Phe Leu Ser 
    690                 695                 700                 


Asn Asn Asn Leu Met Gln Ile Leu Thr Asp Glu Thr Leu Gln Lys Lys 
705                 710                 715                 720 


Met Thr Glu Leu Asn Ala Asp Lys Leu Lys Ala Ala Asn Ile Asn Asp 
                725                 730                 735     


Ala Ile Asp Asp Ala Tyr Thr Ser Pro Ser Asn Lys Lys Ala Leu Arg 
            740                 745                 750         


Gln Val Leu Arg Val Ile Glu Asp Ile Lys Arg Ala Ala Asp Gly Gln 
        755                 760                 765             


Asp Pro Ser Trp Leu Tyr Val Glu Thr Ala Asp Gly Gly Gly Thr Pro 
    770                 775                 780                 


Gly Lys Arg Thr Arg Ala Arg Gln His Gln Leu Gln Glu Ile Tyr Ala 
785                 790                 795                 800 


Asn Ala Ala His Glu Leu Ile Asp Ser Ala Val Arg Gly Glu Leu Glu 
                805                 810                 815     


Asp Lys Ile Ala Asp Lys Ala Asp Phe Asn Asp Arg Leu Val Leu Tyr 
            820                 825                 830         


Phe Met Gln Gly Gly Arg Asp Ile Tyr Thr Gly Thr Pro Leu Asn Ile 
        835                 840                 845             


Asp Gln Leu Ser Ser Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Leu 
    850                 855                 860                 


Ile Lys Asp Asn Ser Leu Asp Asn Arg Val Leu Val His Ala Ile Ile 
865                 870                 875                 880 


Asn Arg Glu Lys Asn Ala Thr Phe Ala Ser Thr Ile Tyr Ala Gln Lys 
                885                 890                 895     


Met Asn Ala Thr Trp Arg Gln Trp His Glu Ala Gly Leu Ile Ser Gly 
            900                 905                 910         


Arg Lys Leu Arg Asn Leu Gln Met Arg Pro Asp Gln Ile Asp Lys Tyr 
        915                 920                 925             


Ala Ser Gly Phe Val Ala Arg Gln Leu Val Glu Thr Arg Gln Ile Ile 
    930                 935                 940                 


Lys Leu Thr Glu Gln Ile Val Ala Ala Gln Tyr Pro Glu Thr Lys Ile 
945                 950                 955                 960 


Ile Ala Val Lys Ala Gly Leu Ser His Gln Leu Arg Glu Glu Leu Glu 
                965                 970                 975     


Phe Pro Lys Asn Arg Asp Val Asn His Tyr His His Ala Phe Asp Ala 
            980                 985                 990         


Phe Leu Ala Ala Arg Ile Gly Thr  Tyr Leu Leu Lys Arg  Phe Pro Asn 
        995                 1000                 1005             


Leu Gln  Ala Phe Phe Thr Tyr  Gly Lys Phe Lys Lys  Ala Asp Val 
    1010                 1015                 1020             


Lys Lys  Leu Arg Gly Phe Asn  Phe Ile Arg Asp Ile  Thr His Ala 
    1025                 1030                 1035             


Glu Asp  Lys Ile Val Val Lys  Asp Thr Gly Glu Val  Ile Trp Asp 
    1040                 1045                 1050             


Lys Lys  Arg Asp Val Asp Glu  Leu Asp Arg Ile Tyr  Asn Phe Lys 
    1055                 1060                 1065             


Arg Met  Leu Ile Thr His Glu  Val His Phe Glu Lys  Ala Asp Leu 
    1070                 1075                 1080             


Phe Lys  Gln Thr Val Tyr Gly  Ala Lys Asp Ser Lys  Glu Ala Gly 
    1085                 1090                 1095             


Gly Lys  Lys Gln Leu Ile Ser  Lys Lys Lys Gly Tyr  Pro Val Asp 
    1100                 1105                 1110             


Ile Tyr  Gly Gly Tyr Thr Gln  Glu Thr Gly Ser Tyr  Leu Ser Val 
    1115                 1120                 1125             


Val Arg  Leu Thr Lys Lys Ala  Met Tyr Ala Val Val  Lys Val Ser 
    1130                 1135                 1140             


Thr Arg  Asp Ala Ala Lys Leu  Ala Val Ala Lys Ser  Ile Ser Glu 
    1145                 1150                 1155             


Gln Lys  Glu Asn Glu Thr Leu  Asn Asp Ile Ile Asp  Glu Lys Leu 
    1160                 1165                 1170             


Ser Lys  Ile Ser Lys Asn Gly  Lys Ile Thr His Glu  Leu Phe Glu 
    1175                 1180                 1185             


Val Val  Leu Pro Arg Val Gly  Gln Lys Thr Leu Phe  Lys Asn Ser 
    1190                 1195                 1200             


Lys Tyr  Asn Leu Phe Leu Val  Asn Ser Asp Thr Tyr  Met His Asn 
    1205                 1210                 1215             


Tyr Gln  Glu Leu Trp Met Pro  Arg Glu Tyr Gln Lys  Met Trp Lys 
    1220                 1225                 1230             


Asp Ile  Ser Leu Ser Lys Tyr  Gly Asp Ala Gln Thr  Glu Asp Gln 
    1235                 1240                 1245             


Leu Asp  Gln Ile Phe Gly Phe  Ile Val Ser Gln Val  Asn Ser Tyr 
    1250                 1255                 1260             


Phe Asn  Leu Tyr Asp Ile Asn  Gln Phe Arg Lys Lys  Leu Asn Asp 
    1265                 1270                 1275             


Ala Ala  Asp Lys Phe Ala Thr  Leu Pro Met Arg Asp  Thr Asp Asp 
    1280                 1285                 1290             


Met Gln  Gly Lys Ile Ala Thr  Ile Gly Gln Leu Leu  Ile Gly Leu 
    1295                 1300                 1305             


Gln Ala  Asn Ala Ala Arg Ser  Asp Leu Arg Asn Leu  Asp Ile Lys 
    1310                 1315                 1320             


Thr Pro  Leu Gly Leu Leu Gln  Ile Pro Asn Gly Ile  Ser Leu Asp 
    1325                 1330                 1335             


Ser Asp  Thr Ser Val Val Tyr  Gln Ser Pro Thr Gly  Leu Leu Glu 
    1340                 1345                 1350             


Arg Glu  Val His Leu Ser Asp  Leu 
    1355                 1360     


<210> 270
<211> 1363
<212> PRT
<213> Lactobacillus casei


<220>
<223> Lactobacillus casei M36

<400> 270
Met Thr Lys Leu Gly Lys Pro Tyr Gly Ile Gly Val Asp Ile Gly Ser 
1               5                   10                  15      


Asn Ser Ile Gly Phe Ala Ala Val Asp Glu Asn Ser His Leu Ile Arg 
            20                  25                  30          


Leu Lys Gly Lys Thr Val Ile Gly Ala Arg Leu Phe Glu Glu Gly Lys 
        35                  40                  45              


Ala Ala Ala Asp Arg Arg Ala Ser Arg Thr Thr Arg Arg Arg Leu Ser 
    50                  55                  60                  


Arg Asn Arg Trp Arg Leu Ser Phe Leu Arg Asp Phe Phe Glu Ser His 
65                  70                  75                  80  


Ile Thr Pro Thr Asp Pro Asn Phe Phe Met Arg Gln Lys Tyr Ser Glu 
                85                  90                  95      


Ile Ser Pro Lys Asp Lys Ala Arg Tyr Lys Tyr Glu Lys Arg Leu Phe 
            100                 105                 110         


Asn Asp Arg Thr Asp Ala Glu Phe Tyr Gln Gln Tyr Pro Thr Met Tyr 
        115                 120                 125             


His Leu Arg Asn Arg Leu Leu Thr Asp Pro Ser Lys Ala Asp Val Arg 
    130                 135                 140                 


Glu Ile Tyr Phe Ala Ile His His Ile Leu Lys Ser Arg Gly His Phe 
145                 150                 155                 160 


Leu Thr Ser Gly Tyr Ala Lys Asp Phe Asn Thr Asn Lys Val Ala Leu 
                165                 170                 175     


Asn Glu Ile Phe Pro Ala Leu Gln Asp Ala Tyr Ala Gln Val Tyr Pro 
            180                 185                 190         


Asp Leu Asp Ile Thr Phe Asp Glu Asn Lys Val Asn Glu Phe Lys Thr 
        195                 200                 205             


Val Leu Leu Asp Glu Lys Ala Thr Pro Ser Asp Thr Gln Arg Ala Leu 
    210                 215                 220                 


Val Asn Leu Leu Leu Ala Glu Asp Gly Asp Lys Asp Ile Leu Lys Gln 
225                 230                 235                 240 


Gln Lys Gln Val Leu Thr Glu Phe Ala Lys Ala Val Val Gly Leu Lys 
                245                 250                 255     


Met Lys Leu Asn Val Ala Leu Gly Thr Glu Val Asp Ser Ser Glu Ala 
            260                 265                 270         


Thr Ala Trp Asn Phe Ser Leu Gly Gln Leu Asp Asp Lys Trp Ala Gly 
        275                 280                 285             


Ile Glu Ser Ala Met Thr Asp Glu Gly Thr Glu Ile Leu Asp Gln Ile 
    290                 295                 300                 


Arg Asp Leu Tyr Arg Ala Arg Leu Leu Asn Gly Ile Val Pro Ala Gly 
305                 310                 315                 320 


Lys Thr Leu Ser Gln Ala Lys Val Asp Asp Tyr Glu Gln His His Glu 
                325                 330                 335     


Asp Leu Glu Leu Phe Lys Asp Tyr Leu Lys Gln Leu Glu Asp Asp Gly 
            340                 345                 350         


Met Ala Lys Val Ile Arg Gln Leu Tyr Asp Arg Tyr Ile Asp Gly Asp 
        355                 360                 365             


Asp Ala Lys Pro Phe Val Arg Glu Asp Phe Val Lys Ala Leu Thr Lys 
    370                 375                 380                 


Glu Val Thr Ala His Pro Asn Ala Lys Ser Pro Glu Leu Leu Glu Arg 
385                 390                 395                 400 


Leu Val Gln Pro Asp Phe Met Leu Lys Gln Arg Asn Lys Ala Asn Gly 
                405                 410                 415     


Ala Ile Pro Val Gln Met Gln Gln Arg Glu Leu Asp Gln Ile Ile Lys 
            420                 425                 430         


Asn Gln Ser Val Tyr Tyr Asp Trp Leu Ala Ala Pro Asn Pro Val Glu 
        435                 440                 445             


Lys His Arg Gln Ser Met Pro Tyr Gln Leu Asp Glu Leu Leu Asn Phe 
    450                 455                 460                 


Arg Ile Pro Tyr Tyr Val Gly Pro Leu Val Thr Ala Lys Glu Gln Lys 
465                 470                 475                 480 


Ala Ala Gln Gly Gly Val Phe Ala Trp Met Val Arg Lys Asp Pro Asp 
                485                 490                 495     


Gly Asn Ile Thr Pro Tyr Asn Phe Asp Glu Lys Val Asp Arg Glu Ala 
            500                 505                 510         


Ser Ala Asn Thr Phe Ile Gln Arg Met Lys Thr Thr Asp Thr Tyr Leu 
        515                 520                 525             


Ile Gly Glu Asp Val Leu Pro Lys Gln Ser Leu Leu Tyr Gln Ser Tyr 
    530                 535                 540                 


Glu Val Leu Asn Glu Leu Asn Asn Val Arg Val Asn Asp Asn Lys Leu 
545                 550                 555                 560 


Ser Phe Asp Gln Lys Gln Gln Val Leu Gly Glu Leu Phe Glu Arg His 
                565                 570                 575     


Asn Thr Val Thr Ile Lys Gln Phe Val Asp Asn Leu Leu Ala His Gly 
            580                 585                 590         


Asp Tyr Asp Arg Ile Pro Glu Val Arg Gly Leu Ala Asp Glu Lys Arg 
        595                 600                 605             


Phe Leu Ser Ser Leu Ser Thr Tyr Asn Gln Leu Lys Gly Ile Leu His 
    610                 615                 620                 


Glu Ala Ile Asp Asp Ser Asp Lys Gln Thr Asp Ile Glu Lys Ile Ile 
625                 630                 635                 640 


Ala Trp Ser Thr Ile Phe Glu Asp Lys Ala Ile Phe Lys Thr Lys Leu 
                645                 650                 655     


Asn Glu Ile Ser Trp Leu Thr Ala Gly Met Ile Asn Ser Leu Ala Asn 
            660                 665                 670         


Ile Arg Tyr Arg Gly Trp Gly Gln Phe Ser His Lys Leu Leu Asn Glu 
        675                 680                 685             


Leu Thr Leu Ser Thr Gly Arg Thr Val Phe Glu Glu Leu Leu Ile Ser 
    690                 695                 700                 


Ser His Asn Leu Met Gln Ile Leu Thr Asp Glu Val Leu Lys Gln Lys 
705                 710                 715                 720 


Ile Ala Glu Leu Asn Ala His Glu Leu Lys Ala Ser Gly Ile Tyr Ala 
                725                 730                 735     


Ala Ile Asp Asp Ala Tyr Thr Ser Pro Ser Asn Lys Lys Ala Leu Arg 
            740                 745                 750         


Gln Val Leu Ser Val Ile Asp Asp Ile Thr Asn Ala Ala Gly Gln Ala 
        755                 760                 765             


Pro Asn Trp Leu Tyr Ile Glu Thr Ala Asp Gly Asp Gly Val Pro Gly 
    770                 775                 780                 


Lys Arg Thr Asn Ser Arg Gln Arg Lys Ile Gln Glu Ile Tyr Ala Asn 
785                 790                 795                 800 


Ala Ala Gln Glu Leu Ile Thr Gly Ser Val Arg Gly Glu Leu Glu Asp 
                805                 810                 815     


Lys Ile Ala Ser Arg Ala Asp Phe Thr Asp Arg Leu Val Leu Tyr Phe 
            820                 825                 830         


Met Gln Gly Gly Arg Asp Ile Tyr Thr Gly Glu Pro Leu Asn Ile Asp 
        835                 840                 845             


Asn Leu Ser Ser Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Leu Ile 
    850                 855                 860                 


Lys Asp Asn Ser Leu Asp Asn Arg Val Leu Val His Pro Leu Val Asn 
865                 870                 875                 880 


Arg Glu Lys Asp Thr Ile Phe Ala Ser Thr Arg Phe Ala Lys Gln Met 
                885                 890                 895     


Asn Gly Met Trp Arg Gln Trp His Ala Ala Gly Leu Ile Ser Ser Arg 
            900                 905                 910         


Lys Leu Arg Asn Leu Gln Met Arg Pro Asp Glu Ile Asp Lys Tyr Ala 
        915                 920                 925             


Ser Gly Phe Val Ala Arg Gln Leu Val Glu Thr Arg Gln Ile Ile Lys 
    930                 935                 940                 


Leu Thr Glu Gln Ile Val Ala Asp Gln Tyr Pro Asp Ala Lys Ile Ile 
945                 950                 955                 960 


Ala Val Lys Ala Gly Leu Ser Ser Gln Leu Arg Lys Glu Leu Asp Phe 
                965                 970                 975     


Pro Lys Asn Arg Glu Val Asn His Tyr His His Ala Phe Asp Ala Phe 
            980                 985                 990         


Leu Ala Ala Arg Ile Gly Thr Tyr  Leu Leu Lys Arg Tyr  Pro Asn Leu 
        995                 1000                 1005             


Glu Pro  Phe Phe Thr Tyr Gly  Lys Phe Lys Lys Thr  Glu Val Lys 
    1010                 1015                 1020             


Lys Leu  Lys Ser Leu Lys Ser  Phe Asn Phe Ile Arg  Asp Met Thr 
    1025                 1030                 1035             


His Ala  Lys Asp Lys Ile Val  Ala Lys Glu Thr Gly  Glu Ile Val 
    1040                 1045                 1050             


Trp Asp  Asn Ala Ser Asp Ile  Asn Glu Leu Asp Arg  Ile Tyr Asn 
    1055                 1060                 1065             


Phe Lys  Arg Met Leu Ile Thr  His Glu Val Arg Phe  Glu Thr Ala 
    1070                 1075                 1080             


Ser Leu  Phe Lys Gln Thr Leu  Tyr Ala Ala Lys Asn  Ser Lys Asn 
    1085                 1090                 1095             


Arg Gly  Gly Ser Arg Gln Leu  Ile Pro Lys Lys Lys  Gly Tyr Leu 
    1100                 1105                 1110             


Val Asp  Ile Tyr Gly Gly Tyr  Thr Gln Glu Thr Gly  Ser Tyr Leu 
    1115                 1120                 1125             


Ser Val  Val Arg Leu Thr Lys  Lys Ala Met Tyr Ala  Val Val Lys 
    1130                 1135                 1140             


Val Ser  Thr Arg Asp Ala Ala  Lys Leu Ala Val Ala  Lys Ser Ile 
    1145                 1150                 1155             


Ser Glu  Gln Lys Glu Asn Glu  Thr Leu Lys Lys Ile  Ile Asp Gly 
    1160                 1165                 1170             


Lys Leu  Ser Lys Thr Ser Lys  Lys Gly Lys Thr Thr  His Gln Leu 
    1175                 1180                 1185             


Phe Glu  Ile Val Leu Pro Arg  Val Gly Gln Lys Thr  Leu Phe Lys 
    1190                 1195                 1200             


Asn Ser  Lys Tyr Asn Gln Phe  Leu Val Asn Ser Asp  Thr Tyr Met 
    1205                 1210                 1215             


His Asn  Tyr Gln Glu Leu Trp  Met Pro Arg Glu Tyr  Gln Arg Met 
    1220                 1225                 1230             


Trp Lys  Asp Ile Leu Leu Ser  Asn His Gly Asp Ala  Gln Leu Glu 
    1235                 1240                 1245             


Gly Gln  Leu Asp Gln Ile Phe  Lys Phe Ile Val Ser  Gln Val Asn 
    1250                 1255                 1260             


Ser Tyr  Phe Asn Leu Tyr Asp  Ile Asn Gln Phe Arg  Lys Lys Ile 
    1265                 1270                 1275             


Ala Asp  Ala Thr Asp Lys Phe  Ala Lys Leu Pro Thr  His Asp Thr 
    1280                 1285                 1290             


Asp Asn  Ala Arg Gly Lys Ile  Ala Thr Ile Gly Gln  Leu Leu Ile 
    1295                 1300                 1305             


Gly Leu  Gln Ala Asn Ala Met  Arg Ser Asp Leu Arg  Asn Leu Asp 
    1310                 1315                 1320             


Ile Lys  Thr Pro Phe Gly Leu  Leu Gln Ile Gly Thr  Gly Ile Thr 
    1325                 1330                 1335             


Leu Asp  Leu Asp Thr Ser Ile  Ile Tyr Gln Ser Pro  Thr Gly Leu 
    1340                 1345                 1350             


Phe Glu  Arg Glu Val Pro Leu  Thr Asp Leu 
    1355                 1360             


<210> 271
<211> 1361
<212> PRT
<213> Lactobacillus casei


<220>
<223> Lactobacillus casei group

<400> 271
Met Thr Lys Leu Gly Lys Pro Tyr Gly Ile Gly Val Asp Ile Gly Ser 
1               5                   10                  15      


Asn Ser Ile Gly Phe Ala Ala Val Asp Glu Asn Ser His Leu Ile Arg 
            20                  25                  30          


Leu Lys Gly Lys Thr Val Ile Gly Ala Arg Leu Phe Glu Glu Gly Lys 
        35                  40                  45              


Ala Ala Ala Asp Arg Arg Ala Ser Arg Thr Thr Arg Arg Arg Leu Ser 
    50                  55                  60                  


Arg Asn Arg Trp Arg Leu Ser Phe Leu Arg Asp Phe Phe Glu Ser His 
65                  70                  75                  80  


Ile Thr Pro Thr Gly Pro Asn Phe Phe Met Arg Gln Lys Tyr Ser Glu 
                85                  90                  95      


Ile Ser Pro Lys Asp Lys Ala Arg Tyr Lys Tyr Glu Lys Arg Leu Phe 
            100                 105                 110         


Asn Asp Arg Thr Asp Ala Glu Phe Tyr Gln Gln Tyr Pro Thr Met Tyr 
        115                 120                 125             


His Leu Arg Asn Arg Leu Leu Thr Asp Pro Ser Lys Ala Asp Val Arg 
    130                 135                 140                 


Glu Ile Tyr Phe Ala Ile His His Ile Leu Lys Ser Arg Gly His Phe 
145                 150                 155                 160 


Leu Thr Ser Gly Tyr Ala Lys Asp Phe Asn Thr Asn Lys Val Ala Leu 
                165                 170                 175     


Asn Glu Ile Phe Pro Ala Leu Gln Asp Ala Tyr Ala Gln Val Tyr Pro 
            180                 185                 190         


Asp Leu Asp Ile Thr Phe Asp Glu Asn Lys Val Asn Glu Phe Lys Thr 
        195                 200                 205             


Val Leu Leu Asn Glu Lys Ala Thr Pro Ser Asp Thr Gln Arg Ala Leu 
    210                 215                 220                 


Val Asn Leu Leu Leu Ala Glu Asp Gly Asp Lys Asp Ile Leu Lys Gln 
225                 230                 235                 240 


Gln Lys Gln Val Leu Thr Glu Phe Ala Lys Ala Val Val Gly Leu Lys 
                245                 250                 255     


Thr Lys Leu Asn Val Ala Leu Gly Thr Glu Val Asp Ser Ser Glu Ala 
            260                 265                 270         


Thr Val Trp Asn Phe Ser Leu Gly Gln Leu Asp Asp Lys Trp Ala Gly 
        275                 280                 285             


Ile Glu Ser Ala Met Thr Asp Glu Gly Thr Glu Ile Leu Asp Gln Ile 
    290                 295                 300                 


Arg Asp Leu Tyr Arg Ala Arg Leu Leu Asn Gly Ile Val Pro Ala Gly 
305                 310                 315                 320 


Lys Thr Leu Ser Gln Ala Lys Val Asp Asp Tyr Ala Gln His His Glu 
                325                 330                 335     


Asp Leu Glu Leu Phe Lys Asp Tyr Leu Lys Gln Leu Glu Asp Asp Gly 
            340                 345                 350         


Thr Ala Lys Ala Ile Arg Gln Leu Tyr Asp Arg Tyr Ile Asp Gly Asp 
        355                 360                 365             


Asp Ala Lys Pro Phe Val Arg Glu Asp Phe Val Lys Ala Leu Thr Lys 
    370                 375                 380                 


Glu Val Thr Ala His Pro Asn Ala Lys Ser Pro Glu Leu Leu Glu Arg 
385                 390                 395                 400 


Leu Ala Gln Pro Asp Phe Met Leu Lys Gln Arg Asn Lys Ala Asn Gly 
                405                 410                 415     


Ala Ile Pro Val Gln Met Gln Gln Arg Glu Leu Asp Gln Ile Ile Lys 
            420                 425                 430         


Asn Gln Ser Val Tyr Tyr Asp Trp Leu Ala Ala Pro Asn Pro Val Glu 
        435                 440                 445             


Lys His Arg Lys Ser Met Pro Tyr Gln Leu Asp Glu Leu Leu Asn Phe 
    450                 455                 460                 


Arg Ile Pro Tyr Tyr Val Gly Pro Leu Val Thr Ala Lys Glu Gln Lys 
465                 470                 475                 480 


Ala Ala Gln Gly Gly Val Phe Ala Trp Met Val Arg Lys Asp Pro Asp 
                485                 490                 495     


Gly Asn Ile Thr Pro Tyr Asn Phe Asp Glu Lys Val Asp Arg Glu Ala 
            500                 505                 510         


Ser Ala Asn Thr Phe Ile Gln Arg Met Lys Thr Thr Asp Thr Tyr Leu 
        515                 520                 525             


Ile Gly Glu Asp Val Leu Pro Lys Gln Ser Leu Leu Tyr Gln Arg Tyr 
    530                 535                 540                 


Glu Val Leu Asn Glu Leu Asn Asn Val Arg Val Asn Asn Glu Lys Leu 
545                 550                 555                 560 


Ser Ile Glu Gln Lys Gln Gln Val Ile Arg Glu Leu Phe Glu Arg His 
                565                 570                 575     


Asn Ser Val Thr Ile Lys Gln Phe Ala Glu Asn Leu Arg Ala His Gly 
            580                 585                 590         


Asp Tyr Ala His Ile Pro Glu Ile Arg Gly Leu Ala Asp Glu Lys Arg 
        595                 600                 605             


Phe Leu Ser Ser Leu Ser Thr Tyr Arg Gln Leu Lys Ser Leu Leu Pro 
    610                 615                 620                 


Asp Ala Ile Asp Asp Pro Ala Lys Gln Ala Asp Ile Glu Asn Ile Ile 
625                 630                 635                 640 


Ala Trp Ser Thr Val Phe Glu Asp Ala Ala Ile Phe Lys Thr Lys Leu 
                645                 650                 655     


Lys Glu Ile Asn Trp Leu Asp Ser Gln Thr Ile Thr Lys Leu Ser Asn 
            660                 665                 670         


Ile Arg Tyr Arg Gly Trp Gly Gln Phe Ser His Lys Phe Leu Asn Gly 
        675                 680                 685             


Leu Thr Leu Gly Asn Gly His Thr Ile Ile Gln Glu Leu Phe Leu Ser 
    690                 695                 700                 


Asn Asn Asn Leu Met Gln Ile Leu Thr Asp Glu Thr Leu Gln Lys Lys 
705                 710                 715                 720 


Met Thr Glu Leu Asn Ala Asp Lys Leu Lys Ala Ala Asn Ile Asn Asp 
                725                 730                 735     


Ala Ile Asp Asp Ala Tyr Thr Ser Pro Ser Asn Lys Lys Ala Leu Arg 
            740                 745                 750         


Gln Val Leu Arg Val Ile Glu Asp Ile Lys Arg Ala Ala Asp Gly Gln 
        755                 760                 765             


Asp Pro Ser Trp Leu Tyr Val Glu Thr Ala Asp Gly Gly Gly Thr Pro 
    770                 775                 780                 


Gly Lys Arg Thr Arg Ala Arg Gln His Gln Leu Gln Glu Ile Tyr Ala 
785                 790                 795                 800 


Asn Ala Ala His Glu Leu Ile Asp Ser Ala Val Arg Gly Glu Leu Glu 
                805                 810                 815     


Asp Lys Ile Ala Asp Lys Ala Asp Phe Asn Asp Arg Leu Val Leu Tyr 
            820                 825                 830         


Phe Met Gln Gly Gly Arg Asp Ile Tyr Thr Gly Thr Pro Leu Asn Ile 
        835                 840                 845             


Asp Gln Leu Ser Ser Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Leu 
    850                 855                 860                 


Ile Lys Asp Asn Ser Leu Asp Asn Arg Val Leu Val His Ala Ile Ile 
865                 870                 875                 880 


Asn Arg Glu Lys Asn Ala Thr Phe Ala Ser Thr Ile Tyr Ala Gln Lys 
                885                 890                 895     


Met Asn Ala Thr Trp Arg Gln Trp His Glu Ala Gly Leu Ile Ser Gly 
            900                 905                 910         


Arg Lys Leu Arg Asn Leu Gln Met Arg Pro Asp Gln Ile Asp Lys Tyr 
        915                 920                 925             


Ala Ser Gly Phe Val Ala Arg Gln Leu Val Glu Thr Arg Gln Ile Ile 
    930                 935                 940                 


Lys Leu Thr Glu Gln Ile Val Ala Ala Gln Tyr Pro Glu Thr Lys Ile 
945                 950                 955                 960 


Ile Ala Val Lys Ala Gly Leu Ser His Gln Leu Arg Glu Glu Leu Glu 
                965                 970                 975     


Phe Pro Lys Asn Arg Asp Val Asn His Tyr His His Ala Phe Asp Ala 
            980                 985                 990         


Phe Leu Ala Ala Arg Ile Gly Thr  Tyr Leu Leu Lys Arg  Phe Pro Asn 
        995                 1000                 1005             


Leu Gln  Ala Phe Phe Thr Tyr  Gly Lys Phe Lys Lys  Ala Asp Val 
    1010                 1015                 1020             


Lys Lys  Leu Arg Gly Phe Asn  Phe Ile Arg Asp Ile  Thr His Ala 
    1025                 1030                 1035             


Glu Asp  Lys Ile Val Val Lys  Asp Thr Gly Glu Val  Ile Trp Asp 
    1040                 1045                 1050             


Lys Lys  Arg Asp Val Asp Glu  Leu Asp Arg Ile Tyr  Asn Phe Lys 
    1055                 1060                 1065             


Arg Met  Leu Ile Thr His Glu  Val His Phe Glu Lys  Ala Asp Leu 
    1070                 1075                 1080             


Phe Lys  Gln Thr Val Tyr Gly  Ala Lys Asp Ser Lys  Glu Ala Gly 
    1085                 1090                 1095             


Gly Lys  Lys Gln Leu Ile Ser  Lys Lys Lys Gly Tyr  Pro Val Asp 
    1100                 1105                 1110             


Ile Tyr  Gly Gly Tyr Thr Gln  Glu Thr Gly Ser Tyr  Leu Ser Val 
    1115                 1120                 1125             


Val Arg  Leu Thr Lys Lys Ala  Met Tyr Ala Val Val  Lys Val Ser 
    1130                 1135                 1140             


Thr Arg  Asp Ala Ala Lys Leu  Ala Val Ala Lys Ser  Ile Ser Glu 
    1145                 1150                 1155             


Gln Lys  Glu Asn Glu Thr Leu  Asn Asp Ile Ile Asp  Glu Lys Leu 
    1160                 1165                 1170             


Ser Lys  Ile Ser Lys Asn Gly  Lys Ile Thr His Glu  Leu Phe Glu 
    1175                 1180                 1185             


Val Val  Leu Pro Arg Val Gly  Gln Lys Thr Leu Phe  Lys Asn Ser 
    1190                 1195                 1200             


Lys Tyr  Asn Leu Phe Leu Val  Asn Ser Asp Thr Tyr  Met His Asn 
    1205                 1210                 1215             


Tyr Gln  Glu Leu Trp Met Pro  Arg Glu Tyr Gln Lys  Met Trp Lys 
    1220                 1225                 1230             


Asp Ile  Ser Leu Ser Lys Tyr  Gly Asp Ala Gln Thr  Glu Asp Gln 
    1235                 1240                 1245             


Leu Asp  Gln Ile Phe Gly Phe  Ile Val Ser Gln Val  Asn Ser Tyr 
    1250                 1255                 1260             


Phe Asn  Leu Tyr Asp Ile Asn  Gln Phe Arg Lys Lys  Leu Asn Asp 
    1265                 1270                 1275             


Ala Ala  Asp Lys Phe Ala Thr  Leu Pro Met Arg Asp  Thr Asp Asp 
    1280                 1285                 1290             


Met Gln  Gly Lys Ile Ala Thr  Ile Gly Gln Leu Leu  Ile Gly Leu 
    1295                 1300                 1305             


Gln Ala  Asn Ala Ala Arg Ser  Asp Leu Arg Asn Leu  Asp Ile Lys 
    1310                 1315                 1320             


Thr Pro  Leu Gly Leu Leu Gln  Ile Pro Asn Gly Ile  Ser Leu Asp 
    1325                 1330                 1335             


Ser Asp  Thr Ser Val Val Tyr  Gln Ser Pro Thr Gly  Leu Leu Glu 
    1340                 1345                 1350             


Arg Glu  Val His Leu Ser Asp  Leu 
    1355                 1360     


<210> 272
<211> 1360
<212> PRT
<213> Lactobacillus casei


<220>
<223> Lactobacillus casei T71499

<400> 272
Met Thr Lys Leu Gly Lys Pro Tyr Gly Ile Gly Val Asp Ile Gly Ser 
1               5                   10                  15      


Asn Ser Ile Gly Phe Ala Ala Val Asp Glu Asn Ser His Leu Ile Arg 
            20                  25                  30          


Leu Lys Gly Lys Thr Val Ile Gly Ala Arg Leu Phe Glu Glu Gly Lys 
        35                  40                  45              


Ala Ala Ala Asp Arg Arg Ala Ser Arg Thr Thr Arg Arg Arg Leu Ser 
    50                  55                  60                  


Arg Asn Arg Trp Arg Leu Ser Phe Leu Arg Asp Phe Phe Glu Ser His 
65                  70                  75                  80  


Ile Thr Pro Thr Asp Pro Asn Phe Phe Met Arg Gln Lys Tyr Ser Glu 
                85                  90                  95      


Ile Ser Pro Lys Asp Lys Ala Arg Tyr Lys Tyr Glu Lys Arg Leu Phe 
            100                 105                 110         


Asn Asp Arg Thr Asp Ala Glu Phe Tyr Gln Gln Tyr Pro Thr Met Tyr 
        115                 120                 125             


His Leu Arg Thr Arg Leu Leu Thr Asp Pro Ser Lys Ala Asp Val Arg 
    130                 135                 140                 


Glu Ile Tyr Phe Ala Ile His His Ile Leu Lys Ser Arg Gly His Phe 
145                 150                 155                 160 


Leu Thr Pro Gly Tyr Ala Lys Asp Phe Asn Thr Asn Lys Val Ala Leu 
                165                 170                 175     


Asn Glu Ile Phe Pro Ala Leu Gln Asp Ala Tyr Ala Gln Val Tyr Pro 
            180                 185                 190         


Asp Leu Asp Ile Thr Phe Asp Glu Asn Lys Val Asn Glu Phe Lys Thr 
        195                 200                 205             


Val Leu Leu Asn Glu Lys Ala Thr Pro Ser Asp Thr Gln Arg Ala Leu 
    210                 215                 220                 


Val Asn Leu Leu Leu Ala Glu Asp Gly Asp Lys Asp Ile Leu Lys Gln 
225                 230                 235                 240 


Gln Lys Gln Val Leu Thr Glu Phe Ala Lys Ala Val Val Gly Leu Lys 
                245                 250                 255     


Thr Lys Leu Asn Val Ala Leu Gly Thr Glu Val Asp Ser Ser Glu Ala 
            260                 265                 270         


Thr Val Trp Asn Phe Ser Leu Gly Gln Leu Asp Asp Lys Trp Ala Gly 
        275                 280                 285             


Ile Glu Ser Ala Met Thr Asp Glu Gly Thr Glu Ile Leu Asp Gln Ile 
    290                 295                 300                 


Arg Asp Leu Tyr Arg Ala Arg Leu Leu Asn Gly Ile Val Pro Ala Gly 
305                 310                 315                 320 


Lys Thr Leu Ser Gln Ala Lys Val Asp Asp Tyr Ala Gln His His Glu 
                325                 330                 335     


Asp Leu Glu Leu Phe Lys Asp Tyr Leu Lys Gln Leu Glu Asp Asp Gly 
            340                 345                 350         


Thr Ala Lys Ala Ile Arg Gln Leu Tyr Asp Arg Tyr Ile Asp Gly Asp 
        355                 360                 365             


Asp Ala Lys Pro Phe Val Arg Glu Asp Phe Val Lys Ala Leu Thr Lys 
    370                 375                 380                 


Glu Val Thr Ala His Pro Asn Ala Lys Ser Pro Glu Leu Leu Glu Arg 
385                 390                 395                 400 


Leu Ala Gln Pro Asp Phe Met Leu Lys Gln Arg Asn Lys Ala Asn Gly 
                405                 410                 415     


Ala Ile Pro Val Gln Met Gln Gln Arg Glu Leu Asp Gln Ile Ile Lys 
            420                 425                 430         


Asn Gln Ser Val Tyr Tyr Asp Trp Leu Ala Ala Pro Asn Pro Val Glu 
        435                 440                 445             


Lys His Arg Lys Ser Met Pro Tyr Gln Leu Asp Glu Leu Leu Asn Phe 
    450                 455                 460                 


Arg Ile Pro Tyr Tyr Val Gly Pro Leu Val Thr Ala Lys Glu Gln Lys 
465                 470                 475                 480 


Ala Ala Gln Gly Gly Val Phe Ala Trp Met Val Arg Lys Asp Pro Asp 
                485                 490                 495     


Gly Asn Ile Thr Pro Tyr Asn Phe Asp Glu Lys Val Asp Arg Glu Ala 
            500                 505                 510         


Ser Ala Asn Thr Phe Ile Gln Arg Met Lys Thr Thr Asp Thr Tyr Leu 
        515                 520                 525             


Ile Gly Glu Asp Val Leu Pro Lys Gln Ser Leu Leu Tyr Gln Ser Tyr 
    530                 535                 540                 


Glu Val Leu Asn Glu Leu Asn Asn Val Arg Val Asn Asp Asn Lys Leu 
545                 550                 555                 560 


Ser Phe Asp Gln Lys Gln Gln Val Leu Gly Glu Leu Phe Glu Arg His 
                565                 570                 575     


Asn Thr Val Thr Ile Lys Gln Phe Val Asp Asn Leu Leu Ala His Gly 
            580                 585                 590         


Asp Tyr Asp Arg Ile Pro Glu Val Arg Gly Leu Ala Asp Glu Lys Arg 
        595                 600                 605             


Phe Leu Ser Ser Leu Ser Thr Tyr Asn Gln Leu Lys Gly Ile Leu His 
    610                 615                 620                 


Glu Ala Ile Asp Asp Ala Asp Lys Gln Thr Asp Ile Glu Asn Ile Ile 
625                 630                 635                 640 


Ala Trp Ser Thr Ile Phe Glu Asp Lys Ala Ile Phe Lys Thr Lys Leu 
                645                 650                 655     


Asn Glu Ile Ser Trp Leu Asn Ala Gly Met Ile Asn Ser Leu Ala Asn 
            660                 665                 670         


Ile Arg Tyr Arg Gly Trp Gly Gln Phe Ser His Lys Leu Leu Asn Glu 
        675                 680                 685             


Leu Thr Leu Ser Thr Gly Arg Thr Val Phe Glu Glu Leu Leu Ile Ser 
    690                 695                 700                 


Ser Arg Asn Leu Met Gln Ile Leu Thr Asp Glu Val Leu Lys Gln Lys 
705                 710                 715                 720 


Ile Ala Glu Leu Asn Ala His Glu Leu Lys Ala Ser Gly Ile Tyr Ala 
                725                 730                 735     


Ala Ile Asp Asp Ala Tyr Thr Ser Pro Ser Asn Lys Lys Ala Leu Arg 
            740                 745                 750         


Gln Val Leu Ser Val Ile Asp Asp Ile Thr Asn Ala Ala Gly Gln Ala 
        755                 760                 765             


Pro Asn Trp Leu Tyr Ile Glu Thr Ala Asp Gly Asp Gly Val Pro Gly 
    770                 775                 780                 


Lys Arg Thr Asn Ser Arg Gln Arg Lys Ile Gln Glu Ile Tyr Ala Asn 
785                 790                 795                 800 


Ala Ala Gln Glu Leu Ile Thr Gly Ser Val Arg Gly Glu Leu Glu Asp 
                805                 810                 815     


Lys Ile Ala Ser Arg Ala Asp Phe Thr Asp Arg Leu Val Leu Tyr Phe 
            820                 825                 830         


Met Gln Gly Gly Arg Asp Ile Tyr Thr Gly Glu Pro Leu Asn Ile Asp 
        835                 840                 845             


Asn Leu Ser Ser Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Leu Ile 
    850                 855                 860                 


Lys Asp Asn Ser Leu Asp Asn Arg Val Leu Val His Pro Leu Val Asn 
865                 870                 875                 880 


Arg Glu Lys Asp Thr Ile Phe Ala Ser Thr Arg Phe Ala Lys Gln Met 
                885                 890                 895     


Asn Gly Met Trp Arg Gln Trp His Ala Ala Gly Leu Ile Ser Ser Arg 
            900                 905                 910         


Lys Leu Arg Asn Leu Gln Met Arg Pro Asp Glu Ile Asp Lys Tyr Ala 
        915                 920                 925             


Ser Gly Phe Val Ala Arg Gln Leu Val Glu Thr Arg Gln Ile Ile Lys 
    930                 935                 940                 


Leu Thr Glu Gln Ile Val Ala Asp Gln Tyr Pro Asp Thr Lys Ile Ile 
945                 950                 955                 960 


Ala Val Lys Ala Gly Leu Ser Ser Gln Leu Arg Lys Glu Leu Asp Phe 
                965                 970                 975     


Pro Lys Asn Arg Glu Val Asn His Tyr His His Ala Phe Asp Ala Phe 
            980                 985                 990         


Leu Ala Ala Arg Ile Gly Thr Tyr  Leu Leu Lys Arg Tyr  Pro Asn Leu 
        995                 1000                 1005             


Glu Pro  Phe Phe Thr Tyr Gly  Lys Phe Lys Lys Thr  Glu Val Lys 
    1010                 1015                 1020             


Lys Leu  Lys Ser Phe Asn Phe  Ile Arg Asp Met Thr  His Ala Lys 
    1025                 1030                 1035             


Asp Lys  Ile Val Ala Lys Glu  Thr Gly Glu Ile Val  Trp Asp Asn 
    1040                 1045                 1050             


Ala Ser  Asp Ile Asn Glu Leu  Asp Arg Ile Tyr Asn  Phe Lys Arg 
    1055                 1060                 1065             


Met Leu  Ile Thr His Glu Val  Arg Phe Glu Thr Ala  Ser Leu Phe 
    1070                 1075                 1080             


Lys Gln  Thr Leu Tyr Ala Ala  Lys Asn Ser Lys Asn  Arg Gly Gly 
    1085                 1090                 1095             


Ser Arg  Gln Leu Ile Pro Lys  Lys Lys Gly Tyr Leu  Val Asp Ile 
    1100                 1105                 1110             


Tyr Gly  Gly Tyr Thr Gln Glu  Thr Gly Ser Tyr Leu  Ser Val Val 
    1115                 1120                 1125             


Arg Leu  Thr Lys Lys Ala Met  Tyr Ala Val Val Lys  Val Ser Thr 
    1130                 1135                 1140             


Arg Asp  Ala Ala Lys Leu Ala  Val Ala Lys Ser Ile  Ser Glu Gln 
    1145                 1150                 1155             


Lys Glu  Asn Glu Thr Leu Lys  Lys Ile Ile Asp Gly  Lys Leu Ser 
    1160                 1165                 1170             


Lys Thr  Ser Lys Lys Gly Lys  Thr Thr His Gln Leu  Phe Glu Ile 
    1175                 1180                 1185             


Val Leu  Pro Arg Val Gly Gln  Lys Thr Leu Phe Lys  Asn Ser Lys 
    1190                 1195                 1200             


Tyr Asn  Gln Phe Leu Val Asn  Ser Asp Thr Tyr Met  His Asn Tyr 
    1205                 1210                 1215             


Gln Glu  Leu Trp Met Pro Arg  Glu Tyr Gln Arg Met  Trp Lys Asp 
    1220                 1225                 1230             


Ile Leu  Leu Ser Asn His Gly  Asp Ala Gln Leu Glu  Gly Gln Leu 
    1235                 1240                 1245             


Asp Gln  Ile Phe Lys Phe Ile  Val Ser Gln Val Asn  Ser Tyr Phe 
    1250                 1255                 1260             


Asn Leu  Tyr Asp Ile Asn Gln  Phe Arg Lys Lys Ile  Ala Asp Ala 
    1265                 1270                 1275             


Thr Asp  Lys Phe Ala Lys Leu  Pro Thr His Asp Thr  Asp Asn Ala 
    1280                 1285                 1290             


Arg Gly  Lys Ile Ala Thr Ile  Gly Gln Leu Leu Ile  Gly Leu Gln 
    1295                 1300                 1305             


Ala Asn  Ala Met Arg Ser Asp  Leu Arg Asn Leu Asp  Ile Lys Thr 
    1310                 1315                 1320             


Pro Phe  Gly Leu Leu Gln Ile  Gly Thr Gly Ile Thr  Leu Asp Leu 
    1325                 1330                 1335             


Asp Thr  Ser Ile Ile Tyr Gln  Ser Pro Thr Gly Leu  Phe Glu Arg 
    1340                 1345                 1350             


Glu Val  Pro Leu Thr Asp Leu  
    1355                 1360 


<210> 273
<211> 1366
<212> PRT
<213> Lactobacillus casei


<220>
<223> Lactobacillus casei UCD174

<400> 273
Met Thr Lys Leu Gly Lys Pro Tyr Gly Ile Gly Val Asp Ile Gly Ser 
1               5                   10                  15      


Asn Ser Ile Gly Phe Ala Ala Val Asp Glu Asn Ser His Leu Ile Arg 
            20                  25                  30          


Leu Lys Gly Lys Thr Val Ile Gly Ala Arg Leu Phe Glu Glu Gly Lys 
        35                  40                  45              


Ala Ala Ala Tyr Arg Arg Ala Ser Arg Thr Thr Arg Arg Arg Leu Ser 
    50                  55                  60                  


Arg Asn Arg Trp Arg Leu Ser Phe Leu Arg Asp Phe Phe Glu Ser His 
65                  70                  75                  80  


Ile Thr Pro Thr Asp Pro Asn Phe Phe Met Arg Gln Lys Tyr Ser Glu 
                85                  90                  95      


Ile Ser Pro Lys Asp Lys Ala Arg Tyr Lys Tyr Glu Lys Arg Leu Phe 
            100                 105                 110         


Asn Asp Arg Thr Asp Ala Glu Phe Tyr Gln Gln Tyr Pro Thr Met Tyr 
        115                 120                 125             


His Leu Arg Thr Arg Leu Leu Thr Asp Pro Ser Lys Ala Asp Val Arg 
    130                 135                 140                 


Glu Ile Tyr Phe Ala Ile His His Ile Leu Lys Ser Arg Gly His Phe 
145                 150                 155                 160 


Leu Thr Pro Gly Tyr Ala Lys Asp Phe Asn Thr Asn Lys Val Ala Leu 
                165                 170                 175     


Asn Glu Ile Phe Pro Ala Leu Gln Asp Ala Tyr Ala Gln Val Tyr Pro 
            180                 185                 190         


Asp Leu Asp Ile Thr Phe Asp Glu Asn Lys Val Asn Glu Phe Lys Thr 
        195                 200                 205             


Val Leu Leu Asn Glu Lys Ala Thr Pro Ser Asp Thr Gln Arg Ala Leu 
    210                 215                 220                 


Val Asn Leu Leu Leu Ala Lys Glu Gly Asp Arg Asp Ile Leu Lys Gln 
225                 230                 235                 240 


Gln Lys Gln Val Leu Thr Glu Phe Ala Lys Ala Val Val Gly Leu Lys 
                245                 250                 255     


Thr Lys Leu Asn Val Ala Leu Gly Thr Glu Val Asp Ser Ser Glu Ala 
            260                 265                 270         


Thr Ala Trp Asn Phe Ser Leu Gly Gln Leu Asp Asp Lys Trp Ala Gly 
        275                 280                 285             


Ile Glu Ser Ala Met Thr Asp Glu Gly Thr Glu Ile Leu Asp Gln Ile 
    290                 295                 300                 


Arg Asp Leu Tyr Arg Ala Arg Leu Leu Asn Gly Ile Val Pro Ala Gly 
305                 310                 315                 320 


Lys Thr Leu Ser Gln Ala Lys Val Asp Asp Tyr Ala Gln His His Glu 
                325                 330                 335     


Asp Leu Glu Leu Phe Lys Asp Tyr Leu Lys Gln Leu Glu Asp Asp Gly 
            340                 345                 350         


Thr Ala Lys Ala Ile Arg Gln Leu Tyr Asp Arg Tyr Ile Asp Gly Asp 
        355                 360                 365             


Asp Ala Lys Pro Phe Val Arg Glu Asp Phe Val Lys Ala Leu Thr Lys 
    370                 375                 380                 


Glu Val Thr Ala His Pro Asn Ala Lys Ser Pro Glu Leu Leu Glu Arg 
385                 390                 395                 400 


Leu Ala Gln Pro Asp Phe Met Leu Lys Gln Arg Asn Lys Ala Asn Gly 
                405                 410                 415     


Ala Ile Pro Val Gln Met Gln Gln Arg Glu Leu Asp Gln Ile Ile Lys 
            420                 425                 430         


Asn Gln Ala Val Tyr Tyr Asp Trp Leu Ala Ala Pro Asn Pro Val Glu 
        435                 440                 445             


Lys His Arg Gln Ser Met Thr Tyr Gln Leu Asp Glu Leu Leu Asn Phe 
    450                 455                 460                 


Arg Ile Pro Tyr Tyr Val Gly Pro Leu Val Thr Ala Lys Glu Gln Lys 
465                 470                 475                 480 


Ala Ala Gln Gly Gly Val Phe Ala Trp Met Val Arg Lys Asp Pro Asp 
                485                 490                 495     


Gly Asn Ile Thr Pro Tyr Asn Phe Asp Glu Lys Val Asp Arg Glu Ala 
            500                 505                 510         


Ser Ala Asn Thr Phe Ile Gln Arg Met Lys Thr Thr Asp Thr Tyr Leu 
        515                 520                 525             


Ile Gly Glu Asp Val Leu Pro Lys Gln Ser Leu Leu Tyr Gln Ser Tyr 
    530                 535                 540                 


Glu Val Leu Asn Glu Leu Asn Asn Val Arg Val Asn Asp Asn Lys Leu 
545                 550                 555                 560 


Ser Phe Asp Gln Lys Gln Gln Val Leu Gly Glu Leu Phe Glu Arg His 
                565                 570                 575     


Asn Thr Val Thr Ile Lys Gln Phe Val Asp Asn Leu Leu Ala His Gly 
            580                 585                 590         


Asp Tyr Asp Arg Ile Pro Glu Val Arg Gly Leu Ala Asp Glu Lys Arg 
        595                 600                 605             


Phe Leu Ser Ser Leu Ser Thr Tyr Asn Gln Leu Lys Gly Ile Leu His 
    610                 615                 620                 


Glu Ala Ile Asp Asp Ala Asp Lys Gln Thr Asp Ile Glu Asn Ile Ile 
625                 630                 635                 640 


Ala Trp Ser Thr Ile Phe Glu Asp Lys Ala Ile Phe Lys Thr Lys Leu 
                645                 650                 655     


Asn Glu Ile Ser Trp Leu Asn Ala Gly Met Ile Asn Ser Leu Ala Asn 
            660                 665                 670         


Ile Arg Tyr Arg Gly Trp Gly Gln Phe Ser His Lys Leu Leu Asn Glu 
        675                 680                 685             


Leu Thr Leu Ser Thr Gly Arg Thr Val Phe Glu Glu Leu Leu Ile Ser 
    690                 695                 700                 


Ser Arg Asn Leu Met Gln Ile Leu Thr Asp Glu Val Leu Lys Gln Lys 
705                 710                 715                 720 


Ile Ala Glu Leu Asn Ala His Glu Leu Lys Ala Ser Gly Ile Tyr Ala 
                725                 730                 735     


Ala Ile Asp Asp Ala Tyr Thr Ser Pro Ser Asn Lys Lys Ala Leu Arg 
            740                 745                 750         


Gln Val Leu Ser Val Ile Asp Asp Ile Thr Asn Ala Ala Gly Gln Ala 
        755                 760                 765             


Pro Asn Trp Leu Tyr Ile Glu Thr Ala Asp Gly Asp Gly Val Pro Gly 
    770                 775                 780                 


Lys Arg Thr Asn Ser Arg Gln Arg Lys Ile Gln Glu Ile Tyr Ala Asn 
785                 790                 795                 800 


Ala Ala Gln Glu Leu Ile Thr Gly Ser Val Arg Gly Glu Phe Glu Asp 
                805                 810                 815     


Lys Ile Ala Ser Arg Ala Asp Phe Thr Asp Arg Leu Val Leu Tyr Phe 
            820                 825                 830         


Met Gln Gly Gly Arg Asp Ile Tyr Thr Gly Glu Pro Leu Asn Ile Asp 
        835                 840                 845             


Asn Leu Ser Ser Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Leu Ile 
    850                 855                 860                 


Lys Asp Asn Ser Leu Asp Asn Arg Val Leu Val His Pro Leu Val Asn 
865                 870                 875                 880 


Arg Glu Lys Asp Thr Ile Phe Ala Ser Thr Arg Phe Ala Lys Gln Met 
                885                 890                 895     


Asn Gly Met Trp Arg Gln Trp His Ala Ala Gly Leu Ile Ser Ser Arg 
            900                 905                 910         


Lys Leu Arg Asn Leu Gln Met Arg Pro Asp Glu Ile Asp Lys Tyr Ala 
        915                 920                 925             


Ser Gly Phe Val Ala Arg Gln Leu Val Glu Thr Arg Gln Ile Ile Lys 
    930                 935                 940                 


Leu Thr Glu Gln Ile Val Ala Asp Gln Tyr Pro Asp Thr Lys Ile Ile 
945                 950                 955                 960 


Ala Val Lys Ala Gly Leu Ser Ser Gln Leu Arg Lys Glu Leu Asp Phe 
                965                 970                 975     


Pro Lys Asn Arg Glu Val Asn His Tyr His His Ala Phe Asp Ala Phe 
            980                 985                 990         


Leu Ala Ala Arg Ile Gly Thr Tyr  Leu Leu Lys Arg Tyr  Pro Asn Leu 
        995                 1000                 1005             


Glu Pro  Phe Phe Thr Tyr Gly  Lys Phe Lys Lys Thr  Glu Val Lys 
    1010                 1015                 1020             


Lys Leu  Lys Ser Leu Lys Ser  Leu Lys Ser Phe Asn  Phe Ile Arg 
    1025                 1030                 1035             


Asp Met  Thr His Ala Lys Asp  Lys Ile Val Ala Lys  Glu Thr Gly 
    1040                 1045                 1050             


Glu Ile  Val Trp Asp Asn Ala  Ser Asp Ile Asn Glu  Leu Asp Arg 
    1055                 1060                 1065             


Ile Tyr  Asn Phe Lys Arg Met  Leu Ile Thr His Glu  Val Arg Phe 
    1070                 1075                 1080             


Glu Thr  Ala Ser Leu Phe Lys  Gln Thr Leu Tyr Ala  Ala Lys Asn 
    1085                 1090                 1095             


Ser Lys  Asn Arg Gly Gly Ser  Arg Gln Leu Ile Pro  Lys Lys Lys 
    1100                 1105                 1110             


Gly Tyr  Leu Val Asp Ile Tyr  Gly Gly Tyr Thr Gln  Glu Thr Gly 
    1115                 1120                 1125             


Ser Tyr  Leu Ser Val Val Arg  Leu Thr Lys Lys Ala  Met Tyr Ala 
    1130                 1135                 1140             


Val Val  Lys Val Ser Thr Arg  Asp Ala Ala Lys Leu  Ala Val Ala 
    1145                 1150                 1155             


Lys Ser  Ile Ser Glu Gln Lys  Glu Asn Glu Thr Leu  Lys Lys Ile 
    1160                 1165                 1170             


Ile Asp  Gly Lys Leu Ser Lys  Thr Ser Lys Lys Gly  Lys Thr Thr 
    1175                 1180                 1185             


His Gln  Leu Phe Glu Ile Val  Leu Pro Arg Val Gly  Gln Lys Thr 
    1190                 1195                 1200             


Leu Phe  Lys Asn Ser Lys Tyr  Asn Gln Phe Leu Val  Asn Ser Asp 
    1205                 1210                 1215             


Thr Tyr  Met His Asn Tyr Gln  Glu Leu Trp Met Pro  Arg Glu Tyr 
    1220                 1225                 1230             


Gln Arg  Met Trp Lys Asp Ile  Leu Leu Ser Asn His  Gly Asp Ala 
    1235                 1240                 1245             


Gln Ile  Glu Gly Gln Leu Asp  Gln Ile Phe Lys Phe  Ile Val Ser 
    1250                 1255                 1260             


Gln Val  Asn Ser Tyr Phe Asn  Leu Tyr Asp Ile Asn  Gln Phe Arg 
    1265                 1270                 1275             


Lys Lys  Ile Ala Asp Ala Thr  Asp Lys Phe Ala Lys  Leu Pro Thr 
    1280                 1285                 1290             


His Asp  Thr Asp Asn Ala Arg  Gly Lys Ile Ala Thr  Ile Gly Gln 
    1295                 1300                 1305             


Leu Leu  Ile Gly Leu Gln Ala  Asn Ala Met Arg Ser  Asp Leu Arg 
    1310                 1315                 1320             


Asn Leu  Asp Ile Lys Thr Pro  Phe Gly Leu Leu Gln  Ile Gly Thr 
    1325                 1330                 1335             


Gly Ile  Thr Leu Asp Leu Asp  Thr Ser Ile Ile Tyr  Gln Ser Pro 
    1340                 1345                 1350             


Thr Gly  Leu Phe Glu Arg Glu  Val Pro Leu Thr Asp  Leu 
    1355                 1360                 1365     


<210> 274
<211> 1389
<212> PRT
<213> Lactobacillus casei

<400> 274
Met Ile Ile Arg Thr Tyr Glu Leu Lys Thr Ile Thr Thr Ile Ala Ile 
1               5                   10                  15      


Leu Lys Met Phe Gln Leu Leu Thr Gly Gly Leu Ser Met Thr Lys Leu 
            20                  25                  30          


Gly Lys Pro Tyr Gly Ile Gly Val Asp Ile Gly Ser Asn Ser Ile Gly 
        35                  40                  45              


Phe Ala Ala Val Asp Glu Asn Ser His Leu Ile Arg Leu Lys Gly Lys 
    50                  55                  60                  


Thr Val Ile Gly Ala Arg Leu Phe Glu Glu Gly Lys Ala Ala Ala Asp 
65                  70                  75                  80  


Arg Arg Ala Ser Arg Thr Thr Arg Arg Arg Leu Ser Arg Asn Arg Trp 
                85                  90                  95      


Arg Leu Ser Phe Leu Arg Asp Phe Phe Glu Ser His Ile Thr Pro Thr 
            100                 105                 110         


Gly Pro Asn Phe Phe Met Arg Gln Lys Tyr Ser Glu Ile Ser Pro Lys 
        115                 120                 125             


Asp Lys Ala Arg Tyr Lys Tyr Glu Lys Arg Leu Phe Asn Asp Arg Thr 
    130                 135                 140                 


Asp Ala Glu Phe Tyr Gln Gln Tyr Pro Thr Met Tyr His Leu Arg Asn 
145                 150                 155                 160 


Arg Leu Leu Thr Asp Pro Ser Lys Ala Asp Val Arg Glu Ile Tyr Phe 
                165                 170                 175     


Ala Ile His His Ile Leu Lys Ser Arg Gly His Phe Leu Thr Ser Gly 
            180                 185                 190         


Tyr Ala Lys Asp Phe Asn Thr Asn Lys Val Ala Leu Asn Glu Ile Phe 
        195                 200                 205             


Pro Ala Leu Gln Asp Ala Tyr Ala Gln Val Tyr Pro Asp Leu Asp Ile 
    210                 215                 220                 


Thr Phe Asp Glu Asn Lys Val Asn Glu Phe Lys Thr Val Leu Leu Asn 
225                 230                 235                 240 


Glu Lys Ala Thr Pro Ser Asp Thr Gln Arg Ala Leu Val Asn Leu Leu 
                245                 250                 255     


Leu Ala Glu Asp Gly Asp Lys Asp Ile Leu Lys Gln Gln Lys Gln Val 
            260                 265                 270         


Leu Thr Glu Phe Ala Lys Ala Val Val Gly Leu Lys Thr Lys Leu Asn 
        275                 280                 285             


Val Ala Leu Gly Thr Glu Val Asp Ser Ser Glu Ala Thr Val Trp Asn 
    290                 295                 300                 


Phe Ser Leu Gly Gln Leu Asp Asp Lys Trp Ala Gly Ile Glu Ser Ala 
305                 310                 315                 320 


Met Thr Asp Glu Gly Thr Glu Ile Leu Asp Gln Ile Arg Asp Leu Tyr 
                325                 330                 335     


Arg Ala Arg Leu Leu Asn Gly Ile Val Pro Ala Gly Lys Thr Leu Ser 
            340                 345                 350         


Gln Ala Lys Val Asp Asp Tyr Ala Gln His His Glu Asp Leu Glu Leu 
        355                 360                 365             


Phe Lys Asp Tyr Leu Lys Gln Leu Glu Asp Asp Gly Thr Ala Lys Ala 
    370                 375                 380                 


Ile Arg Gln Leu Tyr Asp Arg Tyr Ile Asp Gly Asp Asp Ala Lys Pro 
385                 390                 395                 400 


Phe Val Arg Glu Asp Phe Val Lys Ala Leu Thr Lys Glu Val Thr Ala 
                405                 410                 415     


His Pro Asn Ala Lys Ser Pro Glu Leu Leu Glu Arg Leu Ala Gln Pro 
            420                 425                 430         


Asp Phe Met Leu Lys Gln Arg Asn Lys Ala Asn Gly Ala Ile Pro Val 
        435                 440                 445             


Gln Met Gln Gln Arg Glu Leu Asp Gln Ile Ile Lys Asn Gln Ser Val 
    450                 455                 460                 


Tyr Tyr Asp Trp Leu Ala Ala Pro Asn Pro Val Glu Lys His Arg Lys 
465                 470                 475                 480 


Ser Met Pro Tyr Gln Leu Asp Glu Leu Leu Asn Phe Arg Ile Pro Tyr 
                485                 490                 495     


Tyr Val Gly Pro Leu Val Thr Ala Lys Glu Gln Lys Ala Ala Gln Gly 
            500                 505                 510         


Gly Val Phe Ala Trp Met Val Arg Lys Asp Pro Asp Gly Asn Ile Thr 
        515                 520                 525             


Pro Tyr Asn Phe Asp Glu Lys Val Asp Arg Glu Ala Ser Ala Asn Thr 
    530                 535                 540                 


Phe Ile Gln Arg Met Lys Thr Thr Asp Thr Tyr Leu Ile Gly Glu Asp 
545                 550                 555                 560 


Val Leu Pro Lys Gln Ser Leu Leu Tyr Gln Arg Tyr Glu Val Leu Asn 
                565                 570                 575     


Glu Leu Asn Asn Val Arg Val Asn Asn Glu Lys Leu Ser Ile Glu Gln 
            580                 585                 590         


Lys Gln Gln Val Ile Arg Glu Leu Phe Glu Arg His Asn Ser Val Thr 
        595                 600                 605             


Ile Lys Gln Phe Ala Glu Asn Leu Arg Ala His Gly Asp Tyr Ala His 
    610                 615                 620                 


Ile Pro Glu Ile Arg Gly Leu Ala Asp Glu Lys Arg Phe Leu Ser Ser 
625                 630                 635                 640 


Leu Ser Thr Tyr Arg Gln Leu Lys Ser Leu Leu Pro Asp Ala Ile Asp 
                645                 650                 655     


Asp Pro Ala Lys Gln Ala Asp Ile Glu Asn Ile Ile Ala Trp Ser Thr 
            660                 665                 670         


Val Phe Glu Asp Ala Ala Ile Phe Lys Thr Lys Leu Lys Glu Ile Asn 
        675                 680                 685             


Trp Leu Asp Ser Gln Thr Ile Thr Lys Leu Ser Asn Ile Arg Tyr Arg 
    690                 695                 700                 


Gly Trp Gly Gln Phe Ser His Lys Phe Leu Asn Gly Leu Thr Leu Gly 
705                 710                 715                 720 


Asn Gly His Thr Ile Ile Gln Glu Leu Phe Leu Ser Asn Asn Asn Leu 
                725                 730                 735     


Met Gln Ile Leu Thr Asp Glu Thr Leu Gln Lys Lys Met Thr Glu Leu 
            740                 745                 750         


Asn Ala Asp Lys Leu Lys Ala Ala Asn Ile Asn Asp Ala Ile Asp Asp 
        755                 760                 765             


Ala Tyr Thr Ser Pro Ser Asn Lys Lys Ala Leu Arg Gln Val Leu Arg 
    770                 775                 780                 


Val Ile Glu Asp Ile Lys Arg Ala Ala Asp Gly Gln Asp Pro Ser Trp 
785                 790                 795                 800 


Leu Tyr Val Glu Thr Ala Asp Gly Gly Gly Thr Pro Gly Lys Arg Thr 
                805                 810                 815     


Arg Ala Arg Gln His Gln Leu Gln Glu Ile Tyr Ala Asn Ala Ala His 
            820                 825                 830         


Glu Leu Ile Asp Ser Ala Val Arg Gly Glu Leu Glu Asp Lys Ile Ala 
        835                 840                 845             


Asp Lys Ala Asp Phe Asn Asp Arg Leu Val Leu Tyr Phe Met Gln Gly 
    850                 855                 860                 


Gly Arg Asp Ile Tyr Thr Gly Thr Pro Leu Asn Ile Asp Gln Leu Ser 
865                 870                 875                 880 


Ser Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Leu Ile Lys Asp Asn 
                885                 890                 895     


Ser Leu Asp Asn Arg Val Leu Val His Ala Ile Ile Asn Arg Glu Lys 
            900                 905                 910         


Asn Ala Thr Phe Ala Ser Thr Ile Tyr Ala Gln Lys Met Asn Ala Thr 
        915                 920                 925             


Trp Arg Gln Trp His Glu Ala Gly Leu Ile Ser Gly Arg Lys Leu Arg 
    930                 935                 940                 


Asn Leu Gln Met Arg Pro Asp Gln Ile Asp Lys Tyr Ala Ser Gly Phe 
945                 950                 955                 960 


Val Ala Arg Gln Leu Val Glu Thr Arg Gln Ile Ile Lys Leu Thr Glu 
                965                 970                 975     


Gln Ile Val Ala Ala Gln Tyr Pro Glu Thr Lys Ile Ile Ala Val Lys 
            980                 985                 990         


Ala Gly Leu Ser His Gln Leu Arg  Glu Glu Leu Glu Phe  Pro Lys Asn 
        995                 1000                 1005             


Arg Asp  Val Asn His Tyr His  His Ala Phe Asp Ala  Phe Leu Ala 
    1010                 1015                 1020             


Ala Arg  Ile Gly Thr Tyr Leu  Leu Lys Arg Phe Pro  Asn Leu Gln 
    1025                 1030                 1035             


Ala Phe  Phe Thr Tyr Gly Lys  Phe Lys Lys Ala Asp  Val Lys Lys 
    1040                 1045                 1050             


Leu Arg  Gly Phe Asn Phe Ile  Arg Asp Ile Thr His  Ala Glu Asp 
    1055                 1060                 1065             


Lys Ile  Val Val Lys Asp Thr  Gly Glu Val Ile Trp  Asp Lys Lys 
    1070                 1075                 1080             


Arg Asp  Val Asp Glu Leu Asp  Arg Ile Tyr Asn Phe  Lys Arg Met 
    1085                 1090                 1095             


Leu Ile  Thr His Glu Val His  Phe Glu Lys Ala Asp  Leu Phe Lys 
    1100                 1105                 1110             


Gln Thr  Val Tyr Gly Ala Lys  Asp Ser Lys Glu Ala  Gly Gly Lys 
    1115                 1120                 1125             


Lys Gln  Leu Ile Ser Lys Lys  Lys Gly Tyr Pro Val  Asp Ile Tyr 
    1130                 1135                 1140             


Gly Gly  Tyr Thr Gln Glu Thr  Gly Ser Tyr Leu Ser  Val Val Arg 
    1145                 1150                 1155             


Leu Thr  Lys Lys Ala Met Tyr  Ala Val Val Lys Val  Ser Thr Arg 
    1160                 1165                 1170             


Asp Ala  Ala Lys Leu Ala Val  Ala Lys Ser Ile Ser  Glu Gln Lys 
    1175                 1180                 1185             


Glu Asn  Glu Thr Leu Asn Asp  Ile Ile Asp Glu Lys  Leu Ser Lys 
    1190                 1195                 1200             


Ile Ser  Lys Asn Gly Lys Ile  Thr His Glu Leu Phe  Glu Val Val 
    1205                 1210                 1215             


Leu Pro  Arg Val Gly Gln Lys  Thr Leu Phe Lys Asn  Ser Lys Tyr 
    1220                 1225                 1230             


Asn Leu  Phe Leu Val Asn Ser  Asp Thr Tyr Met His  Asn Tyr Gln 
    1235                 1240                 1245             


Glu Leu  Trp Met Pro Arg Glu  Tyr Gln Lys Met Trp  Lys Asp Ile 
    1250                 1255                 1260             


Ser Leu  Ser Lys Tyr Gly Asp  Ala Gln Thr Glu Asp  Gln Leu Asp 
    1265                 1270                 1275             


Gln Ile  Phe Gly Phe Ile Val  Ser Gln Val Asn Ser  Tyr Phe Asn 
    1280                 1285                 1290             


Leu Tyr  Asp Ile Asn Gln Phe  Arg Lys Lys Leu Asn  Asp Ala Ala 
    1295                 1300                 1305             


Asp Lys  Phe Ala Thr Leu Pro  Met Arg Asp Thr Asp  Asp Met Gln 
    1310                 1315                 1320             


Gly Lys  Ile Ala Thr Ile Gly  Gln Leu Leu Ile Gly  Leu Gln Ala 
    1325                 1330                 1335             


Asn Ala  Ala Arg Ser Asp Leu  Arg Asn Leu Asp Ile  Lys Thr Pro 
    1340                 1345                 1350             


Leu Gly  Leu Leu Gln Ile Pro  Asn Gly Ile Ser Leu  Asp Ser Asp 
    1355                 1360                 1365             


Thr Ser  Val Val Tyr Gln Ser  Pro Thr Gly Leu Leu  Glu Arg Glu 
    1370                 1375                 1380             


Val His  Leu Ser Asp Leu 
    1385                 


<210> 275
<211> 1354
<212> PRT
<213> Lactobacillus coryniformis


<220>
<223> Lactobacillus coryniformis subsp. coryniformis KCTC 3167

<400> 275
Met Thr Leu His Tyr Asn Val Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Tyr Thr Ile Val Asp Asp Asn Gly Lys Ile Leu Gln Val Lys Gly 
            20                  25                  30          


Lys Asn Gly Tyr Gly Val Arg Val Phe Lys Glu Gly Ala Thr Ala Ala 
        35                  40                  45              


Glu Arg Arg Ile Phe Arg Thr Thr His Arg Arg Leu Lys Arg Arg Lys 
    50                  55                  60                  


Trp Arg Leu Arg Leu Leu Gln Asp Phe Phe Glu Pro Tyr Ile Leu Pro 
65                  70                  75                  80  


Gln Asp Asp Gly Phe Phe Ile Arg Arg Lys Glu Ser Asn Leu Val Leu 
                85                  90                  95      


Asn Asp Arg Asp Glu Asp Thr Ala Ser Leu Phe Asn Asp Arg Ser Asp 
            100                 105                 110         


Arg Asp Phe Tyr Gln Ala Tyr Pro Thr Ile Tyr His Leu Arg Gln Ala 
        115                 120                 125             


Leu Met Thr Glu Lys Arg Gln Phe Asp Val Arg Glu Ile Tyr Leu Ala 
    130                 135                 140                 


Met His His Ile Ile Lys Tyr Arg Gly His Phe Leu Leu Asn Gly Thr 
145                 150                 155                 160 


Val Asn Asn Phe Thr Asn Asn Lys Ile Asp Leu His Ser Asp Phe Glu 
                165                 170                 175     


Glu Leu Asn Ala Leu Leu Leu Asn Val Ile Pro Glu Leu Lys Phe Gln 
            180                 185                 190         


Ile Asp Leu Asp His Ser Thr Met Phe Gln Thr Thr Leu Leu Asn Thr 
        195                 200                 205             


Thr Ile Ser Arg Ser Gly Arg Gln Arg Asp Leu Val Lys Ser Phe Tyr 
    210                 215                 220                 


Asn Gly Ser Asp Asp Lys Gln Leu Ala Lys Gln Gln Lys Ser Val Ala 
225                 230                 235                 240 


Thr Glu Leu Leu Lys Ala Ile Leu Gly Leu Lys Ala Lys Phe His Lys 
                245                 250                 255     


Leu Phe Asn Leu Asp Leu Leu Glu Thr Thr Glu Trp Glu Phe Ser Phe 
            260                 265                 270         


Asp Ala Glu Asp Ile Asp Asp Lys Leu Ala Lys Leu Glu Pro Leu Met 
        275                 280                 285             


Thr Glu Asn Gln Gln Gln Val Met Asp Ile Leu Gln Arg Ile Phe Ala 
    290                 295                 300                 


Ala Ile Thr Leu Asn Gly Ile Val Pro Glu Gly Lys Thr Leu Ser Ala 
305                 310                 315                 320 


Ser Lys Val Asp Ser Tyr Gln Lys His Lys Gln Asp Leu Lys Leu Leu 
                325                 330                 335     


Lys Ala Ile Ala Gln His Ser Asp Lys Lys Thr Ala Thr Val Leu Gln 
            340                 345                 350         


Thr Ala Tyr Asn Glu Tyr Ile Asn Gly Ile Ala Ser Lys Pro Leu Lys 
        355                 360                 365             


Gln Glu Asp Phe Tyr Lys Arg Leu Thr Asn Ala Val Lys Lys Ser Ser 
    370                 375                 380                 


Asp Pro Gln Val Ala Asp Met Leu Ala Leu Ile Asp Gln Glu Lys Phe 
385                 390                 395                 400 


Leu Pro Lys Gln Arg Thr Lys Glu Asn Gly Ala Ile Pro His Gln Leu 
                405                 410                 415     


His Gln Leu Glu Leu Glu Arg Ile Ile Asp Asn Gln Lys Asp Tyr Tyr 
            420                 425                 430         


Pro Trp Leu Ala Glu Leu Asn Pro Asn Gln Ala Arg Gln Lys Val Ala 
        435                 440                 445             


Lys Tyr Lys Leu Ser Glu Leu Val Ala Phe Arg Val Pro Tyr Tyr Val 
    450                 455                 460                 


Gly Pro Leu Ile Glu Pro Glu Val Gln Gln Ala Thr Ser Asn Ala His 
465                 470                 475                 480 


Phe Ala Trp Met Ala Arg Lys Glu Ala Gly Pro Ile Thr Pro Trp Asn 
                485                 490                 495     


Phe Asp Gln Lys Val Asp Arg Asn Val Ser Ala Glu Arg Phe Ile Lys 
            500                 505                 510         


Arg Met Thr Thr Lys Asp Thr Tyr Leu Leu Ala Glu Asp Val Leu Pro 
        515                 520                 525             


Leu His Ser Leu Leu Tyr Gln Arg Phe Ile Val Leu Asn Glu Leu Asn 
    530                 535                 540                 


Asn Val Arg Val Asn Gly Gln Lys Leu Thr Lys Lys Gln Lys Gln Ala 
545                 550                 555                 560 


Val Tyr Gln Asp Leu Phe Lys Arg Gln Pro His Val Thr Lys Lys Gln 
                565                 570                 575     


Phe Lys Ser Tyr Leu Val Gln Thr Gly Glu Phe Ala Glu Ser Ser Lys 
            580                 585                 590         


Ile Glu Gly Leu Ala Asn Glu Thr Ser Phe Asn Ser Gly Leu Thr Thr 
        595                 600                 605             


Glu Asn Glu Leu Arg Lys Ile Phe Gly Ala Gln Leu Asp Glu Ala Arg 
    610                 615                 620                 


Tyr Gln Val Asp Phe Glu Gln Ile Ile Glu Trp Ala Thr Leu Phe Glu 
625                 630                 635                 640 


Asp Ala Lys Ile Leu Arg Thr Lys Leu Ala Glu Ile Thr Trp Leu Thr 
                645                 650                 655     


Thr Glu Gln Ile Glu Lys Leu Ala Gly Ile Arg Tyr Arg Gly Trp Gly 
            660                 665                 670         


Arg Phe Ser Arg Lys Leu Leu Ala Gly Leu Arg Asp Gln Asn Gly Gln 
        675                 680                 685             


Gln Ile Ile Asp Leu Leu Trp Asp Thr Pro Asn Asn Phe Met Val Ile 
    690                 695                 700                 


Val Ser Gln Ala Ala Phe Ser Glu Ala Ile Thr Lys Glu Asn Glu Lys 
705                 710                 715                 720 


Leu Ile Asp Arg Arg Gly Ala Gln Asp Val Ile Thr Asp Leu Tyr Thr 
                725                 730                 735     


Ser Pro Gln Asn Lys Lys Ala Leu Arg Gln Val Leu Ala Ile Val Ala 
            740                 745                 750         


Asp Val Gln Lys Ala Met Gly Gly Val Pro Pro Gln Arg Ile Phe Ile 
        755                 760                 765             


Glu Phe Ala Arg Glu Asp Glu Lys Asn Pro Arg Arg Ser Val Glu Arg 
    770                 775                 780                 


Ser Arg Gln Leu Glu Lys Leu Tyr Gln Thr Ile Ser Asn Glu Phe Leu 
785                 790                 795                 800 


Ile Asn Ser Glu Val Arg Gln Glu Leu Lys Glu Ala Val Asp Gln Lys 
                805                 810                 815     


Val Asn Phe Lys Asp Arg Leu Phe Leu Tyr Phe Leu Gln Gly Gly Val 
            820                 825                 830         


Asp Leu Tyr Ser Gly Lys Arg Ile Asn Ile Asp Gln Leu Ser His Tyr 
        835                 840                 845             


Asp Ile Asp His Ile Leu Pro Gln Ser Phe Ile Lys Asp Asp Ser Leu 
    850                 855                 860                 


Asp Asn Arg Val Leu Val Ser Gln Lys Leu Asn Arg Ser Lys Ser Asp 
865                 870                 875                 880 


Ser Val Pro Leu Ser Glu Phe Ala Asn Tyr Lys Phe Gly Pro Ala Met 
                885                 890                 895     


Gln Ala Lys Trp Leu Gln Leu Lys Glu Ala Gly Leu Leu Ser Lys Arg 
            900                 905                 910         


Lys Tyr Asp Asn Leu Thr Leu Asp Pro Thr Lys Leu Ser Lys Phe Ala 
        915                 920                 925             


Pro Leu Gly Phe Val Asn Arg Gln Leu Val Glu Thr Arg Gln Val Ile 
    930                 935                 940                 


Lys Leu Ala Ala Asn Leu Leu Ala Ser Glu Glu Thr Lys Val Val Thr 
945                 950                 955                 960 


Ile Lys Ala Asn Met Thr His Gln Val Arg Lys Glu Leu Asp Phe Pro 
                965                 970                 975     


Lys Asn Arg Asn Val Asn Asn Tyr His His Ala Phe Asp Ala Tyr Leu 
            980                 985                 990         


Thr Ala Phe Val Gly Ile Phe Leu  Ser Lys Arg Tyr Pro  Lys Leu Lys 
        995                 1000                 1005             


Pro Tyr  Phe Thr Tyr Gly Asp  Phe Gln Lys Gly Asn  Lys Leu Pro 
    1010                 1015                 1020             


Asp Leu  Lys Asn Phe Asn Phe  Leu Tyr Glu Leu Lys  Asn Lys Asp 
    1025                 1030                 1035             


Arg Ser  Ile Asp Ser Asn Thr  Gly Glu Ile Ile Trp  Asp Lys Gln 
    1040                 1045                 1050             


Arg Asp  Leu Ala Tyr Met Asn  Lys Ile Tyr Asn Phe  Lys Lys Val 
    1055                 1060                 1065             


Thr Val  Val His Glu Val Leu  Thr Lys Ser Gly Ala  Leu Tyr Asn 
    1070                 1075                 1080             


Gln Thr  Leu Tyr Lys Ala Ser  Glu Asp Lys Ala Ser  Gly Arg Gly 
    1085                 1090                 1095             


Thr Lys  Gln Leu Ile Arg Lys  Lys Asp Asn Met Pro  Thr Glu Leu 
    1100                 1105                 1110             


Tyr Gly  Gly Tyr Thr Gly Ser  Thr Ser Ala Phe Met  Ser Ile Val 
    1115                 1120                 1125             


Arg Leu  Trp Lys Lys Asp Lys  Pro Tyr Tyr Lys Val  Val Gly Ile 
    1130                 1135                 1140             


Pro Thr  Arg Met Ala Ala Lys  Leu Ala Asn Gln Ala  Gln Leu Leu 
    1145                 1150                 1155             


Asp Tyr  Leu Thr Lys Lys Phe  Thr Thr Arg Lys Leu  Val Lys Lys 
    1160                 1165                 1170             


Thr Gly  Asp Tyr Lys Thr Thr  Val Glu Arg Phe Glu  Leu Val Val 
    1175                 1180                 1185             


Pro Lys  Val Gly Phe Asn Gln  Leu Val Ile Asp Gly  Gly Gln Pro 
    1190                 1195                 1200             


Phe Met  Leu Gly Ser Ala Thr  Tyr Gln Tyr Asn Ala  Arg Glu Leu 
    1205                 1210                 1215             


Phe Ile  Ser Lys Glu Ala Val  Lys Ala Leu Asn Lys  Gln Leu Ser 
    1220                 1225                 1230             


Thr His  Val Asp Leu Val Gln  Val Phe Asp Glu Ile  Leu Val Gln 
    1235                 1240                 1245             


Val Asn  Arg Trp Phe Pro Leu  Tyr Asp Thr Asn Gly  Phe Arg Glu 
    1250                 1255                 1260             


Lys Leu  Ser His Gly Arg Asp  Arg Phe Met Lys Leu  Asn Asp Ser 
    1265                 1270                 1275             


Phe Glu  Glu Lys Ser Asp Thr  Gln Ile Asp Val Leu  Asn Arg Ile 
    1280                 1285                 1290             


Leu Ile  Gly Phe His Ala Asn  Ala Ala Arg Thr Asn  Leu Lys Ile 
    1295                 1300                 1305             


Leu Gly  Leu Gly Thr Asp Leu  Gly Phe Met Thr Gln  Gln Ala Gly 
    1310                 1315                 1320             


Ile Arg  Leu Thr Glu Lys Ala  Ile Leu Val His Gln  Ser Pro Ser 
    1325                 1330                 1335             


Gly Leu  Phe Glu Arg Lys Val  Ala Leu Arg Asp Leu  Lys Gly Leu 
    1340                 1345                 1350             


Arg 
    


<210> 276
<211> 1119
<212> PRT
<213> Lactobacillus coryniformis


<220>
<223> Lactobacillus coryniformis subsp. torquens KCTC 3535

<400> 276
Met Gly Tyr Arg Ile Gly Leu Asp Val Gly Ile Thr Ser Thr Gly Tyr 
1               5                   10                  15      


Ala Val Leu Lys Thr Asp Lys Asn Gly Leu Pro Tyr Lys Ile Leu Thr 
            20                  25                  30          


Leu Asp Ser Val Ile Tyr Pro Arg Ala Glu Asn Pro Gln Thr Gly Ala 
        35                  40                  45              


Ser Leu Ala Glu Pro Arg Arg Ile Lys Arg Gly Leu Arg Arg Arg Thr 
    50                  55                  60                  


Arg Arg Thr Lys Phe Arg Lys Gln Arg Thr Gln Gln Leu Phe Ile His 
65                  70                  75                  80  


Ser Gly Leu Leu Ser Lys Pro Glu Ile Glu Gln Ile Leu Ala Thr Pro 
                85                  90                  95      


Gln Ala Lys Tyr Ser Val Tyr Glu Leu Arg Val Ala Gly Leu Asp Arg 
            100                 105                 110         


Arg Leu Thr Asn Ser Glu Leu Phe Arg Val Leu Tyr Phe Phe Ile Gly 
        115                 120                 125             


His Arg Gly Phe Lys Ser Asn Arg Lys Ala Glu Leu Asn Pro Glu Asn 
    130                 135                 140                 


Glu Ala Asp Lys Lys Gln Met Gly Gln Leu Leu Asn Ser Ile Glu Glu 
145                 150                 155                 160 


Ile Arg Lys Ala Ile Ala Glu Lys Gly Tyr Arg Thr Val Gly Glu Leu 
                165                 170                 175     


Tyr Leu Lys Asp Pro Lys Tyr Asn Asp His Lys Arg Asn Lys Gly Tyr 
            180                 185                 190         


Ile Asp Gly Tyr Leu Ser Thr Pro Asn Arg Gln Met Leu Val Asp Glu 
        195                 200                 205             


Ile Lys Gln Ile Leu Asp Lys Gln Arg Glu Leu Gly Asn Glu Lys Leu 
    210                 215                 220                 


Thr Asp Glu Phe Tyr Ala Thr Tyr Leu Leu Gly Asp Glu Asn Arg Ala 
225                 230                 235                 240 


Gly Ile Phe Gln Ala Gln Arg Asp Phe Asp Glu Gly Pro Gly Ala Gly 
                245                 250                 255     


Pro Tyr Ala Gly Asp Gln Ile Lys Lys Met Val Gly Lys Asp Ile Phe 
            260                 265                 270         


Glu Pro Thr Glu Asp Arg Ala Ala Lys Ala Thr Tyr Thr Phe Gln Tyr 
        275                 280                 285             


Phe Asn Leu Leu Gln Lys Met Thr Ser Leu Asn Tyr Gln Asn Thr Thr 
    290                 295                 300                 


Gly Asp Thr Trp His Thr Leu Asn Gly Leu Asp Arg Gln Ala Ile Ile 
305                 310                 315                 320 


Asp Ala Val Phe Ala Lys Ala Glu Lys Pro Thr Lys Thr Tyr Lys Pro 
                325                 330                 335     


Thr Asp Phe Gly Glu Leu Arg Lys Leu Leu Lys Leu Pro Asp Asp Ala 
            340                 345                 350         


Arg Phe Asn Leu Val Asn Tyr Gly Ser Leu Gln Thr Gln Lys Glu Ile 
        355                 360                 365             


Glu Thr Val Glu Lys Lys Thr Arg Phe Val Asp Phe Lys Ala Tyr His 
    370                 375                 380                 


Asp Leu Val Lys Val Leu Pro Glu Glu Met Trp Gln Ser Arg Gln Leu 
385                 390                 395                 400 


Leu Asp His Ile Gly Thr Ala Leu Thr Leu Tyr Ser Ser Asp Lys Arg 
                405                 410                 415     


Arg Arg Arg Tyr Phe Ala Glu Glu Leu Asn Leu Pro Ala Glu Leu Ile 
            420                 425                 430         


Glu Lys Leu Leu Pro Leu Asn Phe Ser Lys Phe Gly His Leu Ser Ile 
        435                 440                 445             


Lys Ser Met Gln Asn Ile Ile Pro Tyr Leu Glu Met Gly Gln Val Tyr 
    450                 455                 460                 


Ser Glu Ala Thr Thr Asn Thr Gly Tyr Asp Phe Arg Lys Lys Gln Ile 
465                 470                 475                 480 


Ser Lys Asp Thr Ile Arg Glu Glu Ile Thr Asn Pro Val Val Arg Arg 
                485                 490                 495     


Ala Val Thr Lys Thr Ile Lys Ile Val Glu Gln Ile Ile Arg Arg Tyr 
            500                 505                 510         


Gly Lys Pro Asp Gly Ile Asn Ile Glu Leu Ala Arg Glu Leu Gly Arg 
        515                 520                 525             


Asn Phe Lys Glu Arg Gly Asp Ile Gln Lys Arg Gln Asp Lys Asn Arg 
    530                 535                 540                 


Gln Thr Asn Asp Lys Ile Ala Ala Glu Leu Thr Glu Leu Gly Ile Pro 
545                 550                 555                 560 


Val Asn Gly Gln Asn Ile Ile Arg Tyr Lys Leu His Lys Glu Gln Asn 
                565                 570                 575     


Gly Val Asp Pro Tyr Thr Gly Asp Gln Ile Pro Phe Glu Arg Ala Phe 
            580                 585                 590         


Ser Glu Gly Tyr Glu Val Asp His Ile Ile Pro Tyr Ser Ile Ser Trp 
        595                 600                 605             


Asp Asp Ser Tyr Thr Asn Lys Val Leu Thr Ser Ala Lys Cys Asn Arg 
    610                 615                 620                 


Glu Lys Gly Asn Arg Ile Pro Met Val Tyr Leu Ala Asn Asn Glu Gln 
625                 630                 635                 640 


Arg Leu Asn Ala Leu Thr Asn Ile Ala Asp Asn Ile Ile Arg Asn Ser 
                645                 650                 655     


Arg Lys Arg Gln Lys Leu Leu Lys Gln Lys Leu Ser Asp Glu Glu Leu 
            660                 665                 670         


Lys Asp Trp Lys Gln Arg Asn Ile Asn Asp Thr Arg Phe Ile Thr Arg 
        675                 680                 685             


Val Leu Tyr Asn Tyr Phe Arg Gln Ala Ile Glu Phe Asn Pro Glu Leu 
    690                 695                 700                 


Glu Lys Lys Gln Arg Val Leu Pro Leu Asn Gly Glu Val Thr Ser Lys 
705                 710                 715                 720 


Ile Arg Ser Arg Trp Gly Phe Leu Lys Val Arg Glu Asp Gly Asp Leu 
                725                 730                 735     


His His Ala Ile Asp Ala Thr Val Ile Ala Ala Ile Thr Pro Lys Phe 
            740                 745                 750         


Ile Gln Gln Val Thr Lys Tyr Ser Gln His Gln Glu Val Lys Asn Asn 
        755                 760                 765             


Gln Ala Leu Trp His Asp Ala Glu Ile Lys Asp Ala Glu Tyr Ala Ala 
    770                 775                 780                 


Glu Ala Gln Arg Met Asp Ala Asp Leu Phe Asn Lys Ile Phe Asn Gly 
785                 790                 795                 800 


Phe Pro Leu Pro Trp Pro Glu Phe Leu Asp Glu Leu Leu Ala Arg Ile 
                805                 810                 815     


Ser Asp Asn Pro Val Glu Met Met Lys Ser Arg Ser Trp Asn Thr Tyr 
            820                 825                 830         


Thr Pro Ile Glu Ile Ala Lys Leu Lys Pro Val Phe Val Val Arg Leu 
        835                 840                 845             


Ala Asn His Lys Ile Ser Gly Pro Ala His Leu Asp Thr Ile Arg Ser 
    850                 855                 860                 


Ala Lys Leu Phe Asp Glu Lys Gly Ile Val Leu Ser Arg Val Ser Ile 
865                 870                 875                 880 


Thr Lys Leu Lys Ile Asn Lys Lys Gly Gln Val Ala Thr Gly Asp Gly 
                885                 890                 895     


Ile Tyr Asp Pro Glu Asn Ser Asn Asn Gly Asp Lys Val Val Tyr Ser 
            900                 905                 910         


Ala Ile Arg Gln Ala Leu Glu Ala His Asn Gly Ser Gly Glu Leu Ala 
        915                 920                 925             


Phe Pro Asp Gly Tyr Leu Glu Tyr Val Asp His Gly Thr Lys Lys Leu 
    930                 935                 940                 


Val Arg Lys Val Arg Val Ala Lys Lys Val Ser Leu Pro Val Arg Leu 
945                 950                 955                 960 


Lys Asn Lys Ala Ala Ala Asp Asn Gly Ser Met Val Arg Ile Asp Val 
                965                 970                 975     


Phe Asn Thr Gly Lys Lys Phe Val Phe Val Pro Ile Tyr Ile Lys Asp 
            980                 985                 990         


Thr Val Glu Gln Val Leu Pro Asn  Lys Ala Ile Ala Arg  Gly Lys Ser 
        995                 1000                 1005             


Leu Trp  Tyr Gln Ile Thr Glu  Ser Asp Gln Phe Cys  Phe Ser Leu 
    1010                 1015                 1020             


Tyr Pro  Gly Asp Met Val His  Ile Glu Ser Lys Thr  Gly Ile Lys 
    1025                 1030                 1035             


Pro Lys  Tyr Ser Asn Lys Glu  Asn Asn Thr Ser Val  Val Pro Ile 
    1040                 1045                 1050             


Lys Asn  Phe Tyr Gly Tyr Phe  Asp Gly Ala Asp Ile  Ala Thr Ala 
    1055                 1060                 1065             


Ser Ile  Leu Val Arg Ala His  Asp Ser Ser Tyr Thr  Ala Arg Ser 
    1070                 1075                 1080             


Ile Gly  Ile Ala Gly Leu Leu  Lys Phe Glu Lys Tyr  Gln Val Asp 
    1085                 1090                 1095             


Tyr Phe  Gly Arg Tyr His Lys  Val His Glu Lys Lys  Arg Gln Leu 
    1100                 1105                 1110             


Phe Val  Lys Arg Asp Glu 
    1115                 


<210> 277
<211> 1368
<212> PRT
<213> Lactobacillus curvatus


<220>
<223> Lactobacillus curvatus CRL 705

<400> 277
Met Ser Arg Pro Tyr Asn Ile Gly Leu Asp Ile Gly Thr Ser Ser Ile 
1               5                   10                  15      


Gly Trp Ser Val Val Asp Asp Gln Ser Lys Leu Val Ser Val Arg Gly 
            20                  25                  30          


Lys Tyr Gly Tyr Gly Val Arg Leu Tyr Asp Glu Gly Gln Thr Ala Ala 
        35                  40                  45              


Glu Arg Arg Ser Phe Arg Thr Thr Arg Arg Arg Leu Lys Arg Arg Lys 
    50                  55                  60                  


Trp Arg Leu Gly Leu Leu Arg Glu Ile Phe Glu Pro Tyr Ile Thr Pro 
65                  70                  75                  80  


Ile Asp Asp Thr Phe Phe Leu Arg Gln Lys Gln Ser Asn Leu Ser Pro 
                85                  90                  95      


Lys Asp Gln Arg Lys Leu Tyr Thr Gln Thr Ser Leu Phe Asn Asp Arg 
            100                 105                 110         


Thr Asp Arg Ala Phe Tyr Asp Asp Tyr Pro Thr Ile Tyr His Leu Arg 
        115                 120                 125             


Tyr Arg Leu Met Thr Glu Lys Arg Gln Phe Asp Ile Arg Glu Ile Tyr 
    130                 135                 140                 


Leu Ala Met His His Ile Val Lys Tyr Arg Gly His Phe Leu Asn Glu 
145                 150                 155                 160 


Ala Pro Val Ser Ser Phe Lys Ser Ser Glu Ile Asn Leu Val Ala His 
                165                 170                 175     


Phe Asp Arg Leu Asn Thr Ile Phe Ala Asp Leu Phe Ser Glu Ser Gly 
            180                 185                 190         


Phe Gln Leu Glu Thr Asp Lys Leu Ala Glu Val Lys Ala Leu Leu Leu 
        195                 200                 205             


Asp Asn Gln Gln Ser Ala Ser Asn Arg Gln Arg Gln Ala Leu Ser Leu 
    210                 215                 220                 


Ile Tyr Thr Pro Ser Thr Asn Lys Ala Val Glu Lys Gln Asn Lys Ala 
225                 230                 235                 240 


Ile Ala Thr Glu Leu Leu Lys Ala Ile Leu Gly Leu Lys Ala Lys Phe 
                245                 250                 255     


Asn Val Leu Thr Gly Ile Glu Ala Glu Asp Val Lys Ala Trp Thr Leu 
            260                 265                 270         


Thr Phe Asn Ala Glu Asn Phe Asp Glu Glu Met Val Lys Leu Glu Ser 
        275                 280                 285             


Ser Leu Asp Asp Asn Ala His Gln Ile Ile Glu Ser Leu Gln Glu Leu 
    290                 295                 300                 


Tyr Ser Gly Val Leu Leu Ala Gly Ile Val Pro Glu Asn Gln Ser Leu 
305                 310                 315                 320 


Ser Gln Ala Met Ile Thr Lys Tyr Asp Asp His Gln Lys His Leu Lys 
                325                 330                 335     


Met Leu Lys Ala Val Arg Glu Ala Leu Ala Pro Gly Asp Arg Gln Arg 
            340                 345                 350         


Leu Lys Gln Ala Tyr Asp Gln Tyr Val Asp Gly Gln Glu Asn Thr Lys 
        355                 360                 365             


Ala Tyr Ser Lys Glu Asp Phe Tyr Gly Asp Ile Thr Lys Ala Leu Lys 
    370                 375                 380                 


Asn Asn Pro Asp His Pro Ile Val Ser Glu Ile Lys Lys Leu Ile Glu 
385                 390                 395                 400 


Leu Asp Gln Phe Met Pro Lys Gln Arg Thr Lys Asp Asn Gly Ala Ile 
                405                 410                 415     


Pro His Gln Leu His Gln Gln Glu Leu Asp Arg Ile Ile Glu Asn Gln 
            420                 425                 430         


Gln Gln Tyr Tyr Pro Trp Leu Ala Glu Leu Asn Pro Asn Ser Lys Arg 
        435                 440                 445             


Gln Thr Val Ala Lys Tyr Lys Leu Asp Glu Leu Val Ala Phe Arg Val 
    450                 455                 460                 


Pro Tyr Tyr Val Gly Pro Leu Ile Thr Ala Glu Gln Gln Arg Gln Ser 
465                 470                 475                 480 


Ser Asp Ala Lys Phe Ala Trp Leu Ile Arg Lys Ala Glu Gly Arg Ile 
                485                 490                 495     


Thr Pro Trp Asn Phe Asp Asp Lys Val Asp Arg Gln Ala Ser Ala Asn 
            500                 505                 510         


Glu Phe Ile Lys Arg Met Thr Thr Thr Asp Thr Tyr Leu Leu Ala Glu 
        515                 520                 525             


Asp Val Leu Pro Lys Gln Ser Leu Ile Tyr Gln Arg Phe Glu Val Leu 
    530                 535                 540                 


Asn Glu Leu Asn Gly Leu Lys Ile Asp Asp Gln Pro Ile Thr Thr Glu 
545                 550                 555                 560 


Leu Lys Gln Ala Ile Phe Thr Asp Leu Phe Met Gln Lys Ile Ser Val 
                565                 570                 575     


Thr Val Lys Asn Ile Gln Asp Tyr Leu Val Ser Glu Lys Arg Tyr Ala 
            580                 585                 590         


Ser Arg Pro Ala Ile Thr Gly Leu Ser Asp Glu Asn Lys Phe Asn Ser 
        595                 600                 605             


Arg Leu Ser Thr Tyr His Asp Leu Lys Met Ile Val Gly Asp Ala Val 
    610                 615                 620                 


Asp Asp Val Asp Lys Gln Ala Asp Leu Glu Lys Cys Ile Glu Trp Ser 
625                 630                 635                 640 


Thr Ile Phe Glu Asp Gly Lys Ile Tyr Ser Ala Lys Leu Asn Glu Ile 
                645                 650                 655     


Asp Trp Leu Thr Asp Gln Gln Arg Val Gln Leu Ala Ala Lys Arg Tyr 
            660                 665                 670         


Arg Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Thr Gln Ile Val Asn 
        675                 680                 685             


Ala Asn Gly Gln Arg Ile Met Asp Leu Leu Trp Asp Thr Thr Asp Asn 
    690                 695                 700                 


Phe Met Arg Ile Val His Ser Glu Asp Phe Asp Lys Leu Ile Thr Glu 
705                 710                 715                 720 


Ala Asn Gln Met Met Leu Ala Glu Asn Asp Val Gln Asp Val Ile Asn 
                725                 730                 735     


Asp Leu Tyr Thr Ser Pro Gln Asn Lys Lys Ala Leu Arg Gln Ile Leu 
            740                 745                 750         


Leu Val Val Asn Asp Ile Gln Lys Ala Met Lys Gly Gln Ala Pro Glu 
        755                 760                 765             


Arg Ile Leu Ile Glu Phe Ala Arg Glu Asp Glu Val Asn Ser Arg Leu 
    770                 775                 780                 


Ser Val Gln Arg Lys Arg Gln Val Glu Gln Val Tyr Gln Asn Ile Ser 
785                 790                 795                 800 


Asn Glu Leu Leu Asn Asn Thr Glu Ile Arg Asn Glu Leu Lys Asp Leu 
                805                 810                 815     


Ser Asn Ser Ala Leu Ser Asn Thr Arg Leu Phe Leu Tyr Phe Met Gln 
            820                 825                 830         


Gly Gly Arg Asp Met Tyr Thr Gly Asp Ser Leu Asn Ile Asp Arg Leu 
        835                 840                 845             


Ser Thr Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Phe Ile Lys Asp 
    850                 855                 860                 


Asn Ser Leu Asp Asn Arg Val Leu Val Ser Gln Lys Met Asn Arg Ser 
865                 870                 875                 880 


Lys Ala Asp Gln Val Pro Thr Asp Phe Thr Ser Val Glu Leu Gly Gln 
                885                 890                 895     


Lys Met Gln Ile Gln Trp Glu Gln Met Leu Arg Ala Gly Leu Ile Thr 
            900                 905                 910         


Lys Lys Lys Tyr Asp Asn Leu Thr Leu Asn Pro Asp His Ile Ser Lys 
        915                 920                 925             


Tyr Ala Met Lys Gly Phe Ile Asn Arg Gln Leu Val Glu Thr Arg Gln 
    930                 935                 940                 


Val Ile Lys Leu Ala Thr Asn Leu Leu Met Glu Gln Tyr Gly Glu Asp 
945                 950                 955                 960 


Asn Ile Glu Leu Ile Thr Val Lys Ser Gly Leu Thr His Gln Met Arg 
                965                 970                 975     


Thr Glu Phe Asp Phe Pro Lys Asn Arg Asn Leu Asn Asn His His His 
            980                 985                 990         


Ala Phe Asp Ala Tyr Leu Thr Ala  Phe Val Gly Leu Tyr  Leu Leu Lys 
        995                 1000                 1005             


Arg Tyr  Pro Lys Leu Lys Pro  Tyr Phe Val Tyr Gly  Glu Tyr Gln 
    1010                 1015                 1020             


Lys Ala  Ser Gln Gln Asp Lys  Trp Arg Asn Phe Asn  Phe Leu Asn 
    1025                 1030                 1035             


Gly Leu  Lys Lys Asp Glu Leu  Val Asp Glu Asn Thr  Glu Ala Val 
    1040                 1045                 1050             


Ile Trp  Asp Lys Glu Ser Gly  Leu Ala Tyr Leu Asn  Lys Ile Tyr 
    1055                 1060                 1065             


Gln Phe  Lys Lys Ile Leu Val  Thr Arg Gly Val His  Glu Asn Ser 
    1070                 1075                 1080             


Gly Ala  Leu Phe Asn Gln Thr  Leu Tyr Ala Ala Lys  Asp Asp Lys 
    1085                 1090                 1095             


Ala Ser  Gly Gln Gly Gly Lys  Gln Leu Ile Pro Ala  Lys Gln Asp 
    1100                 1105                 1110             


Arg Ser  Thr Ala Leu Tyr Gly  Gly Tyr Ser Gly Lys  Thr Val Ala 
    1115                 1120                 1125             


Tyr Met  Cys Ile Val Arg Ile  Lys Asn Lys Lys Gly  Asp Leu Tyr 
    1130                 1135                 1140             


Lys Val  Cys Gly Val Glu Thr  Ser Trp Leu Ala Gln  Leu Lys Gln 
    1145                 1150                 1155             


Leu Thr  Asp Glu Asp Ser Gln  Lys Ala Phe Leu Glu  Gln Lys Ile 
    1160                 1165                 1170             


Ser Pro  Gln Phe Thr Lys Val  Lys Lys Gln Lys Gly  Asn Ile Ile 
    1175                 1180                 1185             


Glu Ala  Val Glu Glu Phe Glu  Val Ile Ala Pro His  Ile Leu Ile 
    1190                 1195                 1200             


Asn Gln  Arg Phe Phe Asp Asn  Gly Gln Glu Leu Thr  Leu Gly Ser 
    1205                 1210                 1215             


Ala Thr  Tyr Lys His Asn Glu  Gln Glu Leu Ile Leu  Asp Lys Thr 
    1220                 1225                 1230             


Ala Val  Lys Leu Leu Asn Gly  Ala Leu Pro Leu Thr  Gln Ser Glu 
    1235                 1240                 1245             


Glu Leu  Ala Glu Gln Val Tyr  Asp Glu Ile Leu Asp  Gln Val Met 
    1250                 1255                 1260             


His Tyr  Phe Pro Leu Tyr Asp  Thr Asn Gln Phe Arg  Ala Lys Leu 
    1265                 1270                 1275             


Ser Thr  Gly Lys Ala Ala Phe  Met Lys Leu Pro Trp  Lys Ser Gln 
    1280                 1285                 1290             


Trp Asp  Gly Asn Lys Met Val  Gln Val Gly Gln Gln  Val Ile Leu 
    1295                 1300                 1305             


Asp Arg  Ile Leu Ile Gly Leu  His Ala Asn Ala Ala  Met Ser Asp 
    1310                 1315                 1320             


Leu Lys  Val Leu Lys Met Thr  Thr Pro Phe Gly Met  Ile Gln Gln 
    1325                 1330                 1335             


Ser Thr  Gly Ile Thr Leu Ser  Ala Asp Thr Gln Ile  Ile Tyr Gln 
    1340                 1345                 1350             


Ser Pro  Thr Gly Leu Phe Glu  Arg Arg Val Ala Leu  Arg Asp Leu 
    1355                 1360                 1365             


<210> 278
<211> 1126
<212> PRT
<213> Lactobacillus farciminis


<220>
<223> Lactobacillus farciminis KCTC 3681

<400> 278
Met Ala Asp Arg Ile Ser Leu Gly Leu Asp Ile Gly Val Ala Ser Val 
1               5                   10                  15      


Gly Phe Ser Val Leu Asp Ile Asp Lys Gly Lys Val Ile Glu Leu Gly 
            20                  25                  30          


Ala Arg Leu Phe Ser Ala Thr Val Ala Ala Gly Asn Gln Asp Arg Arg 
        35                  40                  45              


Asp Met Arg Gly Ala Arg Arg Leu Leu Asn Arg Asn Lys Gln Arg Arg 
    50                  55                  60                  


Gln Asp Thr Gly Lys Leu Phe Lys Lys Phe Gly Leu Ile Asp Asp Phe 
65                  70                  75                  80  


Asp Lys Gly Ser Phe Tyr Asp Asn Phe Asn Gln Asn Leu Asn Pro Tyr 
                85                  90                  95      


Glu Leu Arg Val Lys Gly Leu Thr Glu Gln Leu Thr Lys Glu Glu Leu 
            100                 105                 110         


Ala Glu Ser Leu Tyr Gln Ile Val Lys His Arg Gly Ile Ser Tyr Ala 
        115                 120                 125             


Leu Lys Asp Ala Asp Val Asp Glu Gly Gly Thr Asp Tyr Ser Val Ser 
    130                 135                 140                 


Leu Lys Ile Asn Ser Gln Glu Leu Ala Glu Lys Thr Pro Ala Gln Ile 
145                 150                 155                 160 


Gln Leu Gln Arg Leu Asn Asp Tyr Gly Lys Val Arg Gly Gln Val Val 
                165                 170                 175     


Ile Gly Asp Asp Pro Asp Asn Gln Lys Val Leu Leu Asn Val Phe Pro 
            180                 185                 190         


Thr Ser Ala Tyr Glu Lys Glu Ala Lys Gln Ile Ile Ala Thr Gln Gln 
        195                 200                 205             


Gln Phe Tyr Pro Glu Ser Leu Thr Asp Lys Phe Thr Glu Glu Tyr Cys 
    210                 215                 220                 


Gln Ile Leu Thr Arg Lys Arg Asp Tyr Phe Val Gly Pro Gly Asn Glu 
225                 230                 235                 240 


Lys Ser Arg Thr Asp Tyr Gly Ile Tyr Lys Thr Asp Gly Arg Thr Leu 
                245                 250                 255     


Asp Asn Leu Phe Glu Glu Leu Ile Gly His Asp Lys Ile Tyr Pro Glu 
            260                 265                 270         


Glu Leu Arg Ala Ser Ala Ala Ser Tyr Thr Ala Gln Leu Phe Asn Val 
        275                 280                 285             


Leu Asn Asp Leu Asn Asn Leu Arg Ile Leu Asn Tyr Glu Asp Gly Lys 
    290                 295                 300                 


Leu Thr Lys Glu Asp Lys Glu Lys Ile Ile Ala Glu Ile Lys Asn Asn 
305                 310                 315                 320 


Thr Thr Thr Ile Asn Met Leu Asn Val Ile Lys Lys Val Ala Gly Cys 
                325                 330                 335     


Ser Lys Asp Asp Ile Lys Gly Phe Arg Val Asn Glu Lys Asp Lys Pro 
            340                 345                 350         


Glu Ile Ser Ser Met Pro Val Tyr Arg Lys Ile His Lys Asp Leu Leu 
        355                 360                 365             


Lys Ala Gly Val Asp Ile Ser Asp Trp Pro Val Glu Phe Ile Asp Glu 
    370                 375                 380                 


Leu Ser Phe Ile Leu Thr Leu Asn Thr Glu Asn Gly Glu Ile Arg Lys 
385                 390                 395                 400 


Gln Leu Asn Asn Arg Leu Ala Pro Lys Phe Asp Phe Leu Asn Ala Asp 
                405                 410                 415     


Leu Ile Gln Leu Ile Ile Asp Asn Lys Asp Ser Phe Glu Ile Lys Thr 
            420                 425                 430         


Asn Asn Lys Trp His Arg Phe Ser Val Lys Thr Met Asn Lys Leu Ile 
        435                 440                 445             


Pro Glu Met Met Glu Arg Pro Val Glu Gln Met Thr Leu Leu Asn Glu 
    450                 455                 460                 


Met Gly Leu Val Lys Lys Asp Lys Lys Arg Phe Glu Asn Asn Lys Tyr 
465                 470                 475                 480 


Leu Pro Tyr Lys Glu Ile Ala Lys Asp Ile Phe Asn Pro Val Ala Ser 
                485                 490                 495     


Lys Ser Val Arg Glu Ala Leu Lys Ile Val Asn Ala Val Leu Lys Lys 
            500                 505                 510         


Tyr Gly His Ile Asp Tyr Leu Val Val Glu Met Pro Arg Asp Lys Asn 
        515                 520                 525             


Leu Lys Glu Glu Gln Asp Asn Ile Lys Glu Phe Gln Asn Lys Asn Lys 
    530                 535                 540                 


Lys Ala Lys Asp Ala Ala Phe Glu Ala Phe Val Lys Ser Val Gly Ser 
545                 550                 555                 560 


Glu Gln Arg Val Lys Glu Ala Leu Ser Lys Asn Arg Lys Leu Gln Met 
                565                 570                 575     


Lys Met Arg Leu Trp Tyr Gln Gln Gln Glu Ile Asp Pro Tyr Asn Gly 
            580                 585                 590         


Lys Thr Ile Asp Ala Thr Asp Leu Ile Asn Asn Pro Asp Lys Phe Glu 
        595                 600                 605             


Ile Asp His Ile Ile Pro Gln Ser Ile Ser Phe Tyr Asp Ser Ile Asn 
    610                 615                 620                 


Asn Lys Thr Leu Cys Phe Ala Ser Met Asn Gln Val Lys Gly Gln Lys 
625                 630                 635                 640 


Thr Pro Tyr Glu Phe Met Leu Glu Gly His Gly Gln Ser Tyr Asp Lys 
                645                 650                 655     


Phe Lys Ala Thr Val Met Ala Asn Lys Asn Phe Gly Lys Ala Lys Arg 
            660                 665                 670         


Ala Asn Tyr Leu Phe Glu Glu Asn Val Ser Asp Ile Glu Thr Arg Lys 
        675                 680                 685             


Arg Phe Leu Ser Arg Asn Leu Val Asp Thr Arg Tyr Ser Ser Arg Val 
    690                 695                 700                 


Val Leu Asn Ser Leu Gln Asp Phe Phe Arg Glu Lys Ser Ala Asp Thr 
705                 710                 715                 720 


Lys Val Thr Val Ile Arg Gly Lys Phe Thr Ser Asn Met Arg Lys His 
                725                 730                 735     


Trp His Ile Asp Lys Thr Arg Glu Thr Phe His His His Ala Ile Asp 
            740                 745                 750         


Ala Ser Ile Ile Ala Ala Thr Pro Phe Leu Arg Met Trp Lys Lys Gly 
        755                 760                 765             


Gly Thr Ile Phe Pro Val Lys Val Gly Glu Glu Ser Ile Asp Ile Glu 
    770                 775                 780                 


Thr Gly Glu Ile Leu Asp Asp Lys Asn Phe Asp Lys Ala Met Tyr Glu 
785                 790                 795                 800 


Glu Pro Tyr Ser Gly Phe Val Ser Glu Ile Met Asn Ala Asp Asp Arg 
                805                 810                 815     


Ile Lys Phe Ser His Gln Val Asp Lys Lys Met Asn Arg Lys Val Ser 
            820                 825                 830         


Asp Ala Thr Ile Tyr Ser Thr Arg Thr Gly Lys Leu Ala Lys Asp Lys 
        835                 840                 845             


Lys Asp Ala Glu Tyr Ile Val Ala Lys Val Lys Asp Ile Tyr Ser Val 
    850                 855                 860                 


Asp Gly Phe Lys Lys Phe Lys Lys Val Tyr Asp Lys Asp Lys Thr Lys 
865                 870                 875                 880 


Phe Leu Leu Tyr Lys Tyr Asp Pro Arg Thr Phe Ser Lys Leu Glu Arg 
                885                 890                 895     


Ile Ile Ser Asp Cys Pro Asp Lys Val Glu Lys Val Gln Thr Asn Gly 
            900                 905                 910         


Lys Val Lys Ala Val Asp Ile Ser Pro Phe Glu Met Tyr Arg Arg Asp 
        915                 920                 925             


His Gly Met Ile Lys Lys Tyr Ser Lys Lys Gly Asn Gly Pro Ala Ile 
    930                 935                 940                 


Lys Gln Leu Lys Tyr Leu Asp Lys Lys Leu Gly Ser His Ile Asp Ile 
945                 950                 955                 960 


Thr Pro Ala Asn Ala Asn Gly Lys His Val Ile Leu Gln Ser Leu Lys 
                965                 970                 975     


Pro Trp Arg Thr Asp Val Tyr Leu Asn His Glu Thr Gly Glu Tyr Glu 
            980                 985                 990         


Ile Met Gly Ile Lys Tyr Ser Asp  Leu Lys Phe Asn Lys  Asn Glu Gly 
        995                 1000                 1005             


Tyr Gly  Ile Lys Lys Asp Lys  Tyr Leu Glu Ile Lys  Lys Val Glu 
    1010                 1015                 1020             


Glu Val  Ser Glu Lys Ser Glu  Phe Met Phe Ser Leu  Tyr Arg Lys 
    1025                 1030                 1035             


Asp Arg  Val Lys Val Gln Asp  Met Lys Thr Gly Glu  Ser Val Glu 
    1040                 1045                 1050             


Leu Leu  Phe Trp Ser Arg Asn  Phe Ser Asn Lys Lys  Tyr Ala Glu 
    1055                 1060                 1065             


Leu Lys  Pro Ile Ser Gln Ala  Glu Asn Asp Lys Lys  Leu Pro Val 
    1070                 1075                 1080             


Tyr Gly  Lys Gly Arg Leu Ile  Lys Arg Leu Ile Pro  Lys Asn Cys 
    1085                 1090                 1095             


Lys Ile  Trp Lys Val Asn Thr  Thr Ile Leu Gly Asp  Pro Tyr Tyr 
    1100                 1105                 1110             


Leu Glu  Lys Glu Ser Asp Ser  Pro Lys Asp Ile Leu  Asp 
    1115                 1120                 1125     


<210> 279
<211> 1356
<212> PRT
<213> Lactobacillus farciminis


<220>
<223> Lactobacillus farciminis KCTC 3681

<400> 279
Met Thr Lys Lys Glu Gln Pro Tyr Asn Ile Gly Leu Asp Ile Gly Thr 
1               5                   10                  15      


Ser Ser Val Gly Trp Ala Val Thr Asn Asp Asn Tyr Asp Leu Leu Asn 
            20                  25                  30          


Ile Lys Lys Lys Asn Leu Trp Gly Val Arg Leu Phe Glu Glu Ala Gln 
        35                  40                  45              


Thr Ala Lys Glu Thr Arg Leu Asn Arg Ser Thr Arg Arg Arg Tyr Arg 
    50                  55                  60                  


Arg Arg Lys Asn Arg Ile Asn Trp Leu Asn Glu Ile Phe Ser Glu Glu 
65                  70                  75                  80  


Leu Ala Lys Thr Asp Pro Ser Phe Leu Ile Arg Leu Gln Asn Ser Trp 
                85                  90                  95      


Val Ser Lys Lys Asp Pro Asp Arg Lys Arg Asp Lys Tyr Asn Leu Phe 
            100                 105                 110         


Ile Asp Gly Pro Tyr Thr Asp Lys Glu Tyr Tyr Arg Glu Phe Pro Thr 
        115                 120                 125             


Ile Phe His Leu Arg Lys Glu Leu Ile Leu Asn Lys Asp Lys Ala Asp 
    130                 135                 140                 


Ile Arg Leu Ile Tyr Leu Ala Leu His Asn Ile Leu Lys Tyr Arg Gly 
145                 150                 155                 160 


Asn Phe Thr Tyr Glu His Gln Lys Phe Asn Ile Ser Asn Leu Asn Asn 
                165                 170                 175     


Asn Leu Ser Lys Glu Leu Ile Glu Leu Asn Gln Gln Leu Ile Lys Tyr 
            180                 185                 190         


Asp Ile Ser Phe Pro Asp Asp Cys Asp Trp Asn His Ile Ser Asp Ile 
        195                 200                 205             


Leu Ile Gly Arg Gly Asn Ala Thr Gln Lys Ser Ser Asn Ile Leu Lys 
    210                 215                 220                 


Asp Phe Thr Leu Asp Lys Glu Thr Lys Lys Leu Leu Lys Glu Val Ile 
225                 230                 235                 240 


Asn Leu Ile Leu Gly Asn Val Ala His Leu Asn Thr Ile Phe Lys Thr 
                245                 250                 255     


Ser Leu Thr Lys Asp Glu Glu Lys Leu Asn Phe Ser Gly Lys Asp Ile 
            260                 265                 270         


Glu Ser Lys Leu Asp Asp Leu Asp Ser Ile Leu Asp Asp Asp Gln Phe 
        275                 280                 285             


Thr Val Leu Asp Ala Ala Asn Arg Ile Tyr Ser Thr Ile Thr Leu Asn 
    290                 295                 300                 


Glu Ile Leu Asn Gly Glu Ser Tyr Phe Ser Met Ala Lys Val Asn Gln 
305                 310                 315                 320 


Tyr Glu Asn His Ala Ile Asp Leu Cys Lys Leu Arg Asp Met Trp His 
                325                 330                 335     


Thr Thr Lys Asn Glu Glu Ala Val Glu Gln Ser Arg Gln Ala Tyr Asp 
            340                 345                 350         


Asp Tyr Ile Asn Lys Pro Lys Tyr Gly Thr Lys Glu Leu Tyr Thr Ser 
        355                 360                 365             


Leu Lys Lys Phe Leu Lys Val Ala Leu Pro Thr Asn Leu Ala Lys Glu 
    370                 375                 380                 


Ala Glu Glu Lys Ile Ser Lys Gly Thr Tyr Leu Val Lys Pro Arg Asn 
385                 390                 395                 400 


Ser Glu Asn Gly Val Val Pro Tyr Gln Leu Asn Lys Ile Glu Met Glu 
                405                 410                 415     


Lys Ile Ile Asp Asn Gln Ser Gln Tyr Tyr Pro Phe Leu Lys Glu Asn 
            420                 425                 430         


Lys Glu Lys Leu Leu Ser Ile Leu Ser Phe Arg Ile Pro Tyr Tyr Val 
        435                 440                 445             


Gly Pro Leu Gln Ser Ala Glu Lys Asn Pro Phe Ala Trp Met Glu Arg 
    450                 455                 460                 


Lys Ser Asn Gly His Ala Arg Pro Trp Asn Phe Asp Glu Ile Val Asp 
465                 470                 475                 480 


Arg Glu Lys Ser Ser Asn Lys Phe Ile Arg Arg Met Thr Val Thr Asp 
                485                 490                 495     


Ser Tyr Leu Val Gly Glu Pro Val Leu Pro Lys Asn Ser Leu Ile Tyr 
            500                 505                 510         


Gln Arg Tyr Glu Val Leu Asn Glu Leu Asn Asn Ile Arg Ile Thr Glu 
        515                 520                 525             


Asn Leu Lys Thr Asn Pro Ile Gly Ser Arg Leu Thr Val Glu Thr Lys 
    530                 535                 540                 


Gln Arg Ile Tyr Asn Glu Leu Phe Lys Lys Tyr Lys Lys Val Thr Val 
545                 550                 555                 560 


Lys Lys Leu Thr Lys Trp Leu Ile Ala Gln Gly Tyr Tyr Lys Asn Pro 
                565                 570                 575     


Ile Leu Ile Gly Leu Ser Gln Lys Asp Glu Phe Asn Ser Thr Leu Thr 
            580                 585                 590         


Thr Tyr Leu Asp Met Lys Lys Ile Phe Gly Ser Ser Phe Met Glu Asp 
        595                 600                 605             


Asn Lys Asn Tyr Asp Gln Ile Glu Glu Leu Ile Glu Trp Leu Thr Ile 
    610                 615                 620                 


Phe Glu Asp Lys Gln Ile Leu Asn Glu Lys Leu His Ser Ser Lys Tyr 
625                 630                 635                 640 


Ser Tyr Thr Pro Asp Gln Ile Lys Lys Ile Ser Asn Met Arg Tyr Lys 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Lys Lys Ile Leu Met Asp Ile Thr Thr Glu 
            660                 665                 670         


Thr Asn Thr Pro Gln Leu Leu Gln Leu Ser Asn Tyr Ser Ile Leu Asp 
        675                 680                 685             


Leu Met Trp Ala Thr Asn Asn Asn Phe Ile Ser Ile Met Ser Asn Asp 
    690                 695                 700                 


Lys Tyr Asp Phe Lys Asn Tyr Ile Glu Asn His Asn Leu Asn Lys Asn 
705                 710                 715                 720 


Glu Asp Gln Asn Ile Ser Asp Leu Val Asn Asp Ile His Val Ser Pro 
                725                 730                 735     


Ala Leu Lys Arg Gly Ile Thr Gln Ser Ile Lys Ile Val Gln Glu Ile 
            740                 745                 750         


Val Lys Phe Met Gly His Ala Pro Lys His Ile Phe Ile Glu Val Thr 
        755                 760                 765             


Arg Glu Thr Lys Lys Ser Glu Ile Thr Thr Ser Arg Glu Lys Arg Ile 
    770                 775                 780                 


Lys Arg Leu Gln Ser Lys Leu Leu Asn Lys Ala Asn Asp Phe Lys Pro 
785                 790                 795                 800 


Gln Leu Arg Glu Tyr Leu Val Pro Asn Lys Lys Ile Gln Glu Glu Leu 
                805                 810                 815     


Lys Lys His Lys Asn Asp Leu Ser Ser Glu Arg Ile Met Leu Tyr Phe 
            820                 825                 830         


Leu Gln Asn Gly Lys Ser Leu Tyr Ser Glu Glu Ser Leu Asn Ile Asn 
        835                 840                 845             


Lys Leu Ser Asp Tyr Gln Val Asp His Ile Leu Pro Arg Thr Tyr Ile 
    850                 855                 860                 


Pro Asp Asp Ser Leu Glu Asn Lys Ala Leu Val Leu Ala Lys Glu Asn 
865                 870                 875                 880 


Gln Arg Lys Ala Asp Asp Leu Leu Leu Asn Ser Asn Val Ile Asp Arg 
                885                 890                 895     


Asn Leu Glu Arg Trp Thr Tyr Met Leu Asn Asn Asn Met Ile Gly Leu 
            900                 905                 910         


Lys Lys Phe Lys Asn Leu Thr Arg Arg Val Ile Thr Asp Lys Asp Lys 
        915                 920                 925             


Leu Gly Phe Ile His Arg Gln Leu Val Gln Thr Ser Gln Met Val Lys 
    930                 935                 940                 


Gly Val Ala Asn Ile Leu Asp Asn Met Tyr Lys Asn Gln Gly Thr Thr 
945                 950                 955                 960 


Cys Ile Gln Ala Arg Ala Asn Leu Ser Thr Ala Phe Arg Lys Ala Leu 
                965                 970                 975     


Ser Gly Gln Asp Asp Thr Tyr His Phe Lys His Pro Glu Leu Val Lys 
            980                 985                 990         


Asn Arg Asn Val Asn Asp Phe His  His Ala Gln Asp Ala  Tyr Leu Ala 
        995                 1000                 1005             


Ser Phe  Leu Gly Thr Tyr Arg  Leu Arg Arg Phe Pro  Thr Asn Glu 
    1010                 1015                 1020             


Met Leu  Leu Met Asn Gly Glu  Tyr Asn Lys Phe Tyr  Gly Gln Val 
    1025                 1030                 1035             


Lys Glu  Leu Tyr Ser Lys Lys  Lys Lys Leu Pro Asp  Ser Arg Lys 
    1040                 1045                 1050             


Asn Gly  Phe Ile Ile Ser Pro  Leu Val Asn Gly Thr  Thr Gln Tyr 
    1055                 1060                 1065             


Asp Arg  Asn Thr Gly Glu Ile  Ile Trp Asn Val Gly  Phe Arg Asp 
    1070                 1075                 1080             


Lys Ile  Leu Lys Ile Phe Asn  Tyr His Gln Cys Asn  Val Thr Arg 
    1085                 1090                 1095             


Lys Thr  Glu Ile Lys Thr Gly  Gln Phe Tyr Asp Gln  Thr Ile Tyr 
    1100                 1105                 1110             


Ser Pro  Lys Asn Pro Lys Tyr  Lys Lys Leu Ile Ala  Gln Lys Lys 
    1115                 1120                 1125             


Asp Met  Asp Pro Asn Ile Tyr  Gly Gly Phe Ser Gly  Asp Asn Lys 
    1130                 1135                 1140             


Ser Ser  Ile Thr Ile Val Lys  Ile Asp Asn Asn Lys  Ile Lys Pro 
    1145                 1150                 1155             


Val Ala  Ile Pro Ile Arg Leu  Ile Asn Asp Leu Lys  Asp Lys Lys 
    1160                 1165                 1170             


Thr Leu  Gln Asn Trp Leu Glu  Glu Asn Val Lys His  Lys Lys Ser 
    1175                 1180                 1185             


Ile Gln  Ile Ile Lys Asn Asn  Val Pro Ile Gly Gln  Ile Ile Tyr 
    1190                 1195                 1200             


Ser Lys  Lys Val Gly Leu Leu  Ser Leu Asn Ser Asp  Arg Glu Val 
    1205                 1210                 1215             


Ala Asn  Arg Gln Gln Leu Ile  Leu Pro Pro Glu His  Ser Ala Leu 
    1220                 1225                 1230             


Leu Arg  Leu Leu Gln Ile Pro  Asp Glu Asp Leu Asp  Gln Ile Leu 
    1235                 1240                 1245             


Ala Phe  Tyr Asp Lys Asn Ile  Leu Val Glu Ile Leu  Gln Glu Leu 
    1250                 1255                 1260             


Ile Thr  Lys Met Lys Lys Phe  Tyr Pro Phe Tyr Lys  Gly Glu Arg 
    1265                 1270                 1275             


Glu Phe  Leu Ile Ala Asn Ile  Glu Asn Phe Asn Gln  Ala Thr Thr 
    1280                 1285                 1290             


Ser Glu  Lys Val Asn Ser Leu  Glu Glu Leu Ile Thr  Leu Leu His 
    1295                 1300                 1305             


Ala Asn  Ser Thr Ser Ala His  Leu Ile Phe Asn Asn  Ile Glu Lys 
    1310                 1315                 1320             


Lys Ala  Phe Gly Arg Lys Thr  His Gly Leu Thr Leu  Asn Asn Thr 
    1325                 1330                 1335             


Asp Phe  Ile Tyr Gln Ser Val  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1340                 1345                 1350             


His Ile  Glu 
    1355     


<210> 280
<211> 1313
<212> PRT
<213> Lactobacillus fermentum


<220>
<223> Lactobacillus fermentum 28-3-CHN

<400> 280
Met His Tyr Leu Asp Glu Ile Phe Ala Pro His Leu Gln Glu Val Asp 
1               5                   10                  15      


Glu Asn Phe Leu Arg Arg Leu Lys Gln Ser Asn Ile His Pro Glu Asp 
            20                  25                  30          


Pro Ala Lys Asn Gln Ala Phe Ile Gly Lys Leu Leu Phe Pro Asp Leu 
        35                  40                  45              


Leu Lys Lys Asn Glu Arg Gly Tyr Pro Thr Leu Ile Lys Met Arg Asp 
    50                  55                  60                  


Glu Leu Pro Val Glu Gln Arg Ala His Tyr Pro Val Thr Asn Ile Tyr 
65                  70                  75                  80  


Lys Leu Arg Glu Ala Met Ile Asn Glu Asp Arg Gln Phe Asp Leu Arg 
                85                  90                  95      


Glu Val Tyr Leu Ala Val His His Ile Met Lys Tyr Arg Gly His Phe 
            100                 105                 110         


Leu Asn Asn Ala Ser Val Asp Lys Phe Lys Val Gly Arg Ile Asp Phe 
        115                 120                 125             


Tyr Lys Ser Phe Asn Val Leu Asn Glu Ala Tyr Glu Glu Leu Gln Asn 
    130                 135                 140                 


Gly Glu Gly Ser Phe Thr Ile Glu Pro Ser Lys Val Glu Lys Ile Gly 
145                 150                 155                 160 


Gln Leu Leu Leu Asp Thr Lys Met Arg Lys Leu Asn Arg Gln Lys Ala 
                165                 170                 175     


Val Ala Lys Leu Leu Glu Val Lys Val Ala Asp Lys Glu Glu Thr Lys 
            180                 185                 190         


Arg Asn Lys Gln Ile Ala Thr Ala Met Ser Lys Leu Val Leu Gly Tyr 
        195                 200                 205             


Lys Ala Asp Phe Ala Thr Val Ala Met Ala Asn Gly Asn Glu Trp Lys 
    210                 215                 220                 


Ile Asp Leu Ser Ser Glu Thr Ser Glu Asp Glu Ile Glu Lys Phe Arg 
225                 230                 235                 240 


Glu Glu Leu Ser Asp Ala Gln Asn Asp Ile Leu Thr Glu Ile Thr Ser 
                245                 250                 255     


Leu Phe Ser Gln Ile Met Leu Asn Glu Ile Val Pro Asn Gly Met Ser 
            260                 265                 270         


Ile Ser Glu Ser Met Met Asp Arg Tyr Trp Thr His Glu Arg Gln Leu 
        275                 280                 285             


Ala Glu Val Lys Glu Tyr Leu Ala Thr Gln Pro Ala Ser Ala Arg Lys 
    290                 295                 300                 


Glu Phe Asp Gln Val Tyr Asn Lys Tyr Ile Gly Gln Ala Pro Lys Glu 
305                 310                 315                 320 


Arg Gly Phe Asp Leu Glu Lys Gly Leu Lys Lys Ile Leu Ser Lys Lys 
                325                 330                 335     


Glu Asn Trp Lys Glu Ile Asp Glu Leu Leu Lys Ala Gly Asp Phe Leu 
            340                 345                 350         


Pro Lys Gln Arg Thr Ser Ala Asn Gly Val Ile Pro His Gln Met His 
        355                 360                 365             


Gln Gln Glu Leu Asp Arg Ile Ile Glu Lys Gln Ala Lys Tyr Tyr Pro 
    370                 375                 380                 


Trp Leu Ala Thr Glu Asn Pro Ala Thr Gly Glu Arg Asp Arg His Gln 
385                 390                 395                 400 


Ala Lys Tyr Glu Leu Asp Gln Leu Val Ser Phe Arg Ile Pro Tyr Tyr 
                405                 410                 415     


Val Gly Pro Leu Val Thr Pro Glu Val Gln Lys Ala Thr Ser Gly Ala 
            420                 425                 430         


Lys Phe Ala Trp Ala Lys Arg Lys Glu Asp Gly Glu Ile Thr Pro Trp 
        435                 440                 445             


Asn Leu Trp Asp Lys Ile Asp Arg Ala Glu Ser Ala Glu Ala Phe Ile 
    450                 455                 460                 


Lys Arg Met Thr Val Lys Asp Thr Tyr Leu Leu Asn Glu Asp Val Leu 
465                 470                 475                 480 


Pro Ala Asn Ser Leu Leu Tyr Gln Lys Tyr Asn Val Leu Asn Glu Leu 
                485                 490                 495     


Asn Asn Val Arg Val Asn Gly Arg Arg Leu Ser Val Gly Ile Lys Gln 
            500                 505                 510         


Asp Ile Tyr Thr Glu Leu Phe Lys Lys Lys Lys Thr Val Lys Val Ser 
        515                 520                 525             


Asp Val Ala Ser Leu Val Met Ala Lys Thr Arg Gly Val Asn Lys Pro 
    530                 535                 540                 


Ser Val Glu Gly Leu Ser Asp Pro Lys Lys Phe Asn Ser Asn Leu Ala 
545                 550                 555                 560 


Thr Tyr Leu Asp Leu Lys Ser Ile Val Gly Asp Lys Val Asp Asp Asn 
                565                 570                 575     


Arg Tyr Gln Thr Asp Leu Glu Asn Ile Ile Glu Trp Arg Ser Val Phe 
            580                 585                 590         


Glu Asp Gly Glu Ile Phe Ala Asp Lys Leu Thr Glu Val Glu Trp Leu 
        595                 600                 605             


Thr Asp Gln Gln Arg Ser Ala Leu Val Lys Lys Arg Tyr Lys Gly Trp 
    610                 615                 620                 


Gly Arg Leu Ser Lys Lys Leu Leu Thr Gly Ile Val Asp Glu Asn Gly 
625                 630                 635                 640 


Gln Arg Ile Ile Asp Leu Met Trp Asn Thr Asp Gln Asn Phe Met Gln 
                645                 650                 655     


Ile Val Asn Gln Pro Val Phe Lys Glu Gln Ile Asp Gln Leu Asn Gln 
            660                 665                 670         


Lys Ala Ile Thr Asn Asp Gly Met Thr Leu Arg Glu Trp Val Glu Ser 
        675                 680                 685             


Val Leu Asp Gly Ala Tyr Thr Ser Pro Gln Asn Lys Lys Ala Ile Trp 
    690                 695                 700                 


Gln Val Val Arg Val Val Glu Asp Ile Val Lys Ala Val Gly Asn Ala 
705                 710                 715                 720 


Pro Lys Ser Ile Ser Ile Glu Phe Ala Arg Asn Glu Gly Asn Lys Gly 
                725                 730                 735     


Glu Ile Thr Arg Ser Arg Arg Thr Gln Leu Gln Lys Leu Phe Glu Asp 
            740                 745                 750         


Gln Ala His Glu Leu Val Lys Asp Thr Ser Leu Thr Glu Glu Leu Glu 
        755                 760                 765             


Lys Ala Pro Asp Leu Ser Asp Arg Tyr Tyr Leu Tyr Phe Thr Gln Gly 
    770                 775                 780                 


Gly Lys Asp Met Tyr Thr Gly Asp Pro Ile Asn Phe Asp Glu Ile Ser 
785                 790                 795                 800 


Thr Lys Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Phe Val Lys Asp 
                805                 810                 815     


Asp Ser Leu Asp Asn Arg Val Leu Val Ser Arg Ala Glu Asn Asn Lys 
            820                 825                 830         


Lys Ser Asp Arg Val Pro Ala Lys Leu Tyr Ala Ala Lys Met Lys Pro 
        835                 840                 845             


Tyr Trp Asn Gln Leu Leu Lys Gln Gly Leu Ile Thr Gln Arg Lys Phe 
    850                 855                 860                 


Glu Asn Leu Thr Met Asp Val Asp Gln Asn Ile Lys Tyr Arg Ser Leu 
865                 870                 875                 880 


Gly Phe Val Lys Arg Gln Leu Val Glu Thr Arg Gln Val Ile Lys Leu 
                885                 890                 895     


Thr Ala Asn Ile Leu Gly Ser Met Tyr Gln Glu Ala Gly Thr Asp Ile 
            900                 905                 910         


Ile Glu Thr Arg Ala Gly Leu Thr Lys Gln Leu Arg Glu Glu Phe Asp 
        915                 920                 925             


Leu Pro Lys Val Arg Glu Val Asn Asp Tyr His His Ala Val Asp Ala 
    930                 935                 940                 


Tyr Leu Thr Thr Phe Ala Gly Gln Tyr Leu Asn Arg Arg Tyr Pro Lys 
945                 950                 955                 960 


Leu Arg Ser Phe Phe Val Tyr Gly Glu Tyr Met Lys Phe Lys His Gly 
                965                 970                 975     


Ser Asp Leu Lys Leu Arg Asn Phe Asn Phe Phe His Glu Leu Met Glu 
            980                 985                 990         


Gly Asp Lys Ser Gln Gly Lys Val  Val Asp Gln Gln Thr  Gly Glu Leu 
        995                 1000                 1005             


Ile Thr  Thr Arg Asp Glu Val  Ala Lys Ser Phe Asp  Arg Leu Leu 
    1010                 1015                 1020             


Asn Met  Lys Tyr Met Leu Val  Ser Lys Glu Val His  Asp Arg Ser 
    1025                 1030                 1035             


Asp Gln  Leu Tyr Gly Ala Thr  Ile Val Thr Ala Lys  Glu Ser Gly 
    1040                 1045                 1050             


Lys Leu  Thr Ser Pro Ile Glu  Ile Lys Lys Lys Arg  Pro Val Asp 
    1055                 1060                 1065             


Leu Tyr  Gly Ala Tyr Thr Asn  Gly Thr Ser Ala Phe  Met Thr Ile 
    1070                 1075                 1080             


Ile Lys  Phe Thr Gly Asn Lys  Pro Lys Tyr Lys Val  Ile Gly Val 
    1085                 1090                 1095             


Pro Thr  Thr Ser Ala Val Gly  Leu Lys Arg Val Gly  Lys Pro Gly 
    1100                 1105                 1110             


Ser Glu  Ser Tyr Asn Gln Glu  Leu His Arg Ile Ile  Lys Ser Asn 
    1115                 1120                 1125             


Pro Lys  Val Lys Lys Asp Phe  Glu Ile Val Val Pro  His Val Ser 
    1130                 1135                 1140             


Tyr Ser  Gln Leu Ile Val Asp  Asp Asp Cys Lys Phe  Thr Leu Ala 
    1145                 1150                 1155             


Ser Asp  Thr Tyr Gln His Pro  Ala Thr Gln Leu Val  Leu Ser Lys 
    1160                 1165                 1170             


Glu Ser  Met Glu Ile Ile Ala  Asp Asp Phe Lys Phe  Val Lys Glu 
    1175                 1180                 1185             


Asn Thr  Ala Thr Ala Asp Glu  Gln Leu Val Arg Val  Phe Asp Glu 
    1190                 1195                 1200             


Ile Val  Asn Gln Met Asn His  Tyr Phe Thr Ile Phe  Asp Gln Arg 
    1205                 1210                 1215             


Ser Asn  Arg Gln Lys Val Thr  Lys Ala Arg Asp Lys  Phe Val Ser 
    1220                 1225                 1230             


Leu Pro  Thr Glu Ser Glu Tyr  Glu Gly Ala Lys Lys  Thr Gln Val 
    1235                 1240                 1245             


Gly Lys  Thr Glu Val Ile Thr  Asn Leu Leu Met Gly  Leu His Ala 
    1250                 1255                 1260             


Asn Ser  Ala Gln Gly Asp Leu  Lys Val Leu Gly Leu  Ser Thr Phe 
    1265                 1270                 1275             


Gly Phe  Phe Gln Ser Ser Gly  Gly Leu Asn Leu Ser  Glu Asp Ala 
    1280                 1285                 1290             


Met Ile  Val Tyr Gln Ser Pro  Thr Gly Leu Phe Glu  Arg Arg Ile 
    1295                 1300                 1305             


Cys Leu  Lys Asp Ile 
    1310             


<210> 281
<211> 1381
<212> PRT
<213> Lactobacillus fermentum


<220>
<223> Lactobacillus fermentum ATCC 14931

<400> 281
Met Asp Tyr Val Lys Glu Tyr His Ile Gly Leu Asp Ile Gly Thr Ser 
1               5                   10                  15      


Ser Ile Gly Trp Ala Val Thr Asp Ser Gln Phe Lys Leu Met Arg Ile 
            20                  25                  30          


Lys Gly Lys Thr Ala Ile Gly Val Arg Leu Phe Glu Glu Gly Lys Thr 
        35                  40                  45              


Ala Ala Glu Arg Arg Thr Phe Arg Thr Thr Arg Arg Arg Leu Lys Arg 
    50                  55                  60                  


Arg Lys Trp Arg Leu His Tyr Leu Asp Lys Ile Phe Ala Pro His Leu 
65                  70                  75                  80  


Gln Glu Val Asp Glu Asn Phe Leu Arg Arg Leu Lys Gln Ser Asn Ile 
                85                  90                  95      


His Pro Glu Asp Pro Ala Lys Asn Gln Ala Phe Ile Gly Lys Leu Leu 
            100                 105                 110         


Phe Pro Asp Leu Leu Lys Lys Asn Glu Arg Gly Tyr Pro Thr Leu Ile 
        115                 120                 125             


Lys Met Arg Asp Glu Leu Pro Val Glu Gln Arg Ala His Tyr Pro Val 
    130                 135                 140                 


Thr Asn Ile Tyr Lys Leu Arg Glu Ala Met Ile Asn Glu Asp Arg Gln 
145                 150                 155                 160 


Phe Asp Leu Arg Glu Val Tyr Leu Ala Val His His Ile Val Lys Tyr 
                165                 170                 175     


Arg Gly His Phe Leu Asn Asn Ala Ser Val Asp Lys Phe Lys Val Gly 
            180                 185                 190         


Arg Ile Asp Phe Asp Lys Ser Phe Asn Val Leu Asn Glu Ala Tyr Glu 
        195                 200                 205             


Glu Leu Gln Asn Gly Glu Gly Ser Phe Thr Ile Glu Pro Ser Lys Val 
    210                 215                 220                 


Glu Lys Ile Gly Gln Leu Leu Leu Asp Thr Lys Met Arg Lys Leu Asp 
225                 230                 235                 240 


Arg Gln Lys Ala Val Ala Lys Leu Leu Glu Val Lys Val Ala Asp Lys 
                245                 250                 255     


Glu Glu Thr Lys Arg Asn Lys Gln Ile Ala Thr Ala Met Ser Lys Leu 
            260                 265                 270         


Val Leu Gly Tyr Lys Ala Asp Phe Ala Thr Val Ala Met Ala Asn Gly 
        275                 280                 285             


Asn Glu Trp Lys Ile Asp Leu Ser Ser Glu Thr Ser Glu Asp Glu Ile 
    290                 295                 300                 


Glu Lys Phe Arg Glu Glu Leu Ser Asp Ala Gln Asn Asp Ile Leu Thr 
305                 310                 315                 320 


Glu Ile Thr Ser Leu Phe Ser Gln Ile Met Leu Asn Ala Ile Val Pro 
                325                 330                 335     


Asn Gly Met Ser Ile Ser Glu Ser Met Met Asp Arg Tyr Trp Thr His 
            340                 345                 350         


Glu Arg Gln Leu Ala Glu Val Lys Glu Tyr Leu Ala Thr Gln Pro Ala 
        355                 360                 365             


Ser Ala Arg Lys Glu Phe Asp Gln Val Tyr Asn Lys Tyr Ile Gly Gln 
    370                 375                 380                 


Val Pro Lys Glu Lys Gly Phe Asp Leu Glu Lys Gly Leu Lys Lys Ile 
385                 390                 395                 400 


Leu Ser Lys Lys Glu Asn Trp Lys Glu Ile Asp Glu Leu Leu Lys Ala 
                405                 410                 415     


Gly Asp Phe Leu Pro Lys Gln Arg Thr Ser Ala Asn Gly Val Ile Pro 
            420                 425                 430         


His Gln Met His Gln Gln Glu Leu Asp Arg Ile Ile Glu Lys Gln Ala 
        435                 440                 445             


Lys Tyr Tyr Pro Trp Leu Ala Thr Glu Asn Pro Ala Thr Gly Glu Arg 
    450                 455                 460                 


Asp Arg His Gln Ala Lys Tyr Glu Leu Asp Gln Leu Val Ser Phe Arg 
465                 470                 475                 480 


Ile Pro Tyr Tyr Val Gly Pro Leu Val Thr Pro Glu Val Gln Lys Ala 
                485                 490                 495     


Thr Ser Gly Ala Lys Phe Ala Trp Ala Lys Arg Lys Glu Asp Gly Glu 
            500                 505                 510         


Ile Thr Pro Trp Asn Leu Trp Asp Lys Ile Asp Arg Ala Glu Ser Ala 
        515                 520                 525             


Glu Ala Phe Ile Lys Arg Met Thr Val Lys Asp Thr Tyr Leu Leu Asn 
    530                 535                 540                 


Glu Asp Val Leu Pro Ala Asn Ser Leu Leu Tyr Gln Lys Tyr Asn Val 
545                 550                 555                 560 


Leu Asn Glu Leu Asn Asn Val Arg Val Asn Gly Arg Arg Leu Ser Val 
                565                 570                 575     


Gly Ile Lys Gln Asp Ile Tyr Thr Glu Leu Phe Lys Lys Lys Lys Thr 
            580                 585                 590         


Val Lys Ala Gly Asp Val Ala Ser Leu Val Met Ala Lys Thr Arg Gly 
        595                 600                 605             


Val Asn Lys Pro Ser Val Glu Gly Leu Ser Asp Pro Lys Lys Phe Asn 
    610                 615                 620                 


Ser Asn Leu Ala Thr Tyr Leu Asp Leu Lys Ser Ile Met Gly Asp Lys 
625                 630                 635                 640 


Val Asp Asp Asn Arg Tyr Gln Met Asp Leu Glu Asn Ile Ile Glu Trp 
                645                 650                 655     


Arg Ser Val Phe Glu Asp Gly Glu Ile Phe Ala Asp Lys Leu Thr Glu 
            660                 665                 670         


Val Glu Trp Leu Thr Asp Glu Gln Arg Ser Ala Leu Val Lys Lys Arg 
        675                 680                 685             


Tyr Lys Gly Trp Gly Arg Leu Ser Lys Lys Leu Leu Thr Gly Ile Val 
    690                 695                 700                 


Asp Glu Asn Gly Gln Arg Ile Ile Asp Leu Met Trp Asn Thr Asp Gln 
705                 710                 715                 720 


Asn Phe Met Gln Ile Val Asn Gln Pro Val Phe Lys Glu Gln Ile Asp 
                725                 730                 735     


Gln Leu Asn Gln Lys Ala Ile Thr Asn Asp Gly Met Thr Leu Arg Glu 
            740                 745                 750         


Arg Val Glu Ser Val Leu Asp Asp Ala Tyr Thr Ser Pro Gln Asn Lys 
        755                 760                 765             


Lys Ala Ile Trp Gln Val Val Arg Val Val Glu Asp Ile Val Lys Ala 
    770                 775                 780                 


Val Gly Asn Ala Pro Lys Ser Ile Ser Ile Glu Phe Ala Arg Asn Glu 
785                 790                 795                 800 


Gly Asn Lys Gly Glu Ile Thr Arg Ser Arg Arg Thr Gln Leu Gln Lys 
                805                 810                 815     


Leu Phe Glu Asp Gln Ala His Glu Leu Val Lys Asp Thr Ser Leu Thr 
            820                 825                 830         


Glu Glu Leu Glu Lys Ala Pro Asp Leu Ser Asp Arg Tyr Tyr Phe Tyr 
        835                 840                 845             


Phe Thr Gln Gly Gly Lys Asp Met Tyr Thr Gly Asp Pro Ile Asn Phe 
    850                 855                 860                 


Asp Glu Ile Ser Thr Lys Tyr Asp Ile Asp His Ile Leu Pro Gln Ser 
865                 870                 875                 880 


Phe Val Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Val Ser Arg Ala 
                885                 890                 895     


Glu Asn Asn Lys Lys Ser Asp Arg Val Pro Ala Lys Leu Tyr Ala Ala 
            900                 905                 910         


Lys Met Lys Pro Tyr Trp Asn Gln Leu Leu Lys Gln Gly Leu Ile Thr 
        915                 920                 925             


Gln Arg Lys Phe Glu Asn Leu Thr Met Asp Val Asp Gln Asn Ile Lys 
    930                 935                 940                 


Tyr Arg Ser Leu Gly Phe Val Lys Arg Gln Leu Val Glu Thr Arg Gln 
945                 950                 955                 960 


Val Ile Lys Leu Thr Ala Asn Ile Leu Gly Ser Met Tyr Gln Glu Ala 
                965                 970                 975     


Gly Thr Asp Ile Ile Glu Thr Arg Ala Gly Leu Thr Lys Gln Leu Arg 
            980                 985                 990         


Glu Glu Phe Asp Leu Pro Lys Val  Arg Glu Val Asn Asp  Tyr His His 
        995                 1000                 1005             


Ala Val  Asp Ala Tyr Leu Thr  Thr Phe Ala Gly Gln  Tyr Leu Asn 
    1010                 1015                 1020             


Arg Arg  Tyr Pro Lys Leu Arg  Ser Phe Phe Val Tyr  Gly Glu Tyr 
    1025                 1030                 1035             


Met Lys  Phe Lys His Gly Ser  Asp Leu Lys Leu Arg  Asn Phe Asn 
    1040                 1045                 1050             


Phe Phe  His Glu Leu Met Glu  Gly Asp Lys Ser Gln  Gly Lys Val 
    1055                 1060                 1065             


Val Asp  Gln Gln Thr Gly Glu  Leu Ile Thr Thr Arg  Asp Glu Val 
    1070                 1075                 1080             


Ala Lys  Ser Phe Asp Arg Leu  Leu Asn Met Lys Tyr  Met Leu Val 
    1085                 1090                 1095             


Ser Lys  Glu Val His Asp Arg  Ser Asp Gln Leu Tyr  Gly Ala Thr 
    1100                 1105                 1110             


Ile Val  Thr Ala Lys Glu Ser  Gly Lys Leu Thr Ser  Pro Ile Glu 
    1115                 1120                 1125             


Ile Lys  Lys Asn Arg Pro Val  Asp Leu Tyr Gly Ala  Tyr Thr Asn 
    1130                 1135                 1140             


Gly Thr  Ser Ala Phe Met Thr  Ile Ile Lys Phe Thr  Gly Asn Lys 
    1145                 1150                 1155             


Pro Lys  Tyr Lys Val Ile Gly  Val Pro Thr Thr Ser  Ala Val Gly 
    1160                 1165                 1170             


Leu Lys  Arg Val Gly Lys Pro  Gly Ser Glu Ser Tyr  Asn Gln Glu 
    1175                 1180                 1185             


Leu His  Arg Ile Ile Lys Ser  Asn Pro Lys Val Lys  Lys Asp Phe 
    1190                 1195                 1200             


Glu Ile  Val Val Pro His Val  Ser Tyr Ser Gln Leu  Ile Val Asp 
    1205                 1210                 1215             


Gly Asp  Cys Lys Phe Thr Leu  Ala Ser Asp Thr Tyr  Gln His Pro 
    1220                 1225                 1230             


Ala Thr  Gln Leu Val Leu Ser  Lys Glu Ser Met Glu  Ile Ile Ala 
    1235                 1240                 1245             


Asp Asp  Phe Lys Phe Val Lys  Glu Asn Pro Ala Thr  Ala Asp Glu 
    1250                 1255                 1260             


Gln Leu  Val Arg Val Phe Asp  Glu Ile Val Asn Gln  Met Asn His 
    1265                 1270                 1275             


Tyr Phe  Thr Ile Phe Asp Gln  Arg Ser Asn Arg Gln  Lys Val Thr 
    1280                 1285                 1290             


Lys Ala  Arg Asp Lys Phe Val  Ser Leu Pro Thr Glu  Ser Glu Tyr 
    1295                 1300                 1305             


Glu Gly  Ala Lys Lys Thr Gln  Val Gly Lys Thr Glu  Val Ile Thr 
    1310                 1315                 1320             


Asn Leu  Leu Met Gly Leu His  Ala Asn Ala Ala Gln  Gly Asp Leu 
    1325                 1330                 1335             


Lys Val  Leu Gly Leu Ser Thr  Phe Gly Phe Phe Gln  Ser Ser Gly 
    1340                 1345                 1350             


Gly Leu  Asn Leu Ser Glu Asp  Ala Met Ile Val Tyr  Gln Ser Pro 
    1355                 1360                 1365             


Thr Gly  Leu Phe Glu Arg Arg  Ile Cys Leu Lys Asp  Ile 
    1370                 1375                 1380     


<210> 282
<211> 1327
<212> PRT
<213> Lactobacillus florum


<220>
<223> Lactobacillus florum 2F

<400> 282
Met Thr Glu Gln Gln Gln Pro Tyr Asn Ile Gly Leu Asp Ile Gly Thr 
1               5                   10                  15      


Ser Ser Ile Gly Trp Ala Val Thr Asp Gln Asn Asp Lys Leu Leu His 
            20                  25                  30          


Ile Arg Gly His Asn Gly Ile Gly Val Arg Leu Phe Lys Glu Gly Glu 
        35                  40                  45              


Ser Ala Ala Glu Arg Arg Gly Phe Arg Thr Thr Arg Arg Arg Leu Ser 
    50                  55                  60                  


Arg Arg Arg Trp Arg Leu Arg Phe Leu Asp Arg Ile Phe Asp Ala Glu 
65                  70                  75                  80  


Leu Ala Lys Val Asp Pro Asn Phe Leu Ala Arg Leu Lys Gln Ser Asn 
                85                  90                  95      


Ile Ser Pro Leu Asp Pro Asn Lys Gln Met Phe Gly Asn Ile Leu Phe 
            100                 105                 110         


Asp Asp Pro Gln Phe Asp Asp Gln Lys Phe His Gln Gln Tyr Pro Thr 
        115                 120                 125             


Ile Tyr His Leu Arg Ser Ala Leu Ala Gln Pro Asp Ala Pro Gln Ala 
    130                 135                 140                 


Asp Val Arg Leu Ile Tyr Leu Ala Leu His His Met Ile Lys Phe Arg 
145                 150                 155                 160 


Gly His Phe Leu Asn Gly Ala Ala Val Glu Lys Phe His Gly Gly Gln 
                165                 170                 175     


Leu His Leu Glu Ser Glu Phe Gln Glu Leu Asn Gln Ile Phe Ser Asn 
            180                 185                 190         


Gln Gln Arg Asp His Val Gln Leu Gln Thr Ser Ser Leu Asp Glu Val 
        195                 200                 205             


Ala Thr Ile Leu Lys Asp Asn Gln Arg Thr Pro Ser Asp Arg Gln Arg 
    210                 215                 220                 


Glu Leu Ser Ala Arg Leu Phe Val Pro Val Asp Lys Thr Ile Asp Lys 
225                 230                 235                 240 


Glu Asn Lys Lys Leu Ala Thr Glu Leu Leu Lys Ala Val Leu Gly Leu 
                245                 250                 255     


Lys Ala Lys Phe Asp Val Ile Leu Gly Val Glu Ala Thr Asp Pro Gln 
            260                 265                 270         


Ala Phe Lys Leu Gln Phe Ser Ser Asp Asp Phe Asp Asp Lys Ile Ala 
        275                 280                 285             


Glu Leu Ala Ser Glu Leu Thr Asp Glu Ala Asn Glu Ile Leu Thr Val 
    290                 295                 300                 


Leu Gln Arg Leu Tyr Phe Ser Leu Asn Leu Ala Asp Ile Leu Thr Asn 
305                 310                 315                 320 


Arg Gln Thr Lys Gln Val Ala Asp Ser Ile Ser Thr Ala Met Ile Asn 
                325                 330                 335     


Arg Tyr Asp Asp His Lys His His Leu Lys Met Leu Lys Glu Leu Glu 
            340                 345                 350         


Ala Gln Val Thr Gln Glu Gln Arg Asp Gly Leu Lys Lys Ala Tyr Asp 
        355                 360                 365             


Glu Tyr Ile Asp Gly Asp Lys Pro Thr Ile Asp Thr Phe Tyr Thr Asn 
    370                 375                 380                 


Ile Lys Lys Asn Leu Asp Asp Ser Glu Leu Ala Asn Gln Ile Lys Ser 
385                 390                 395                 400 


Leu Ile Asp Leu Gln Ala Phe Met Pro Lys Gln Arg Ser Lys Glu Asn 
                405                 410                 415     


Gly Ser Ile Pro His Gln Leu His Gln Arg Glu Leu Asp Gln Leu Ile 
            420                 425                 430         


Glu Val Gln Gly Lys Tyr Tyr Pro Trp Leu Leu Ala Ala Lys Asp Lys 
        435                 440                 445             


Leu Asp Ala Leu Ile Ala Phe Arg Val Pro Tyr Tyr Val Gly Pro Met 
    450                 455                 460                 


Ile Asp Pro Asn Gln Ser Asp Asp Pro Gln Asn Thr Lys Phe Ala Trp 
465                 470                 475                 480 


Met Val Arg Lys Glu Ala Gly Glu Ile Thr Pro Trp Asn Phe Glu Glu 
                485                 490                 495     


Lys Val Asp Lys Thr Ser Ser Ala Thr Asn Phe Ile Lys Arg Met Thr 
            500                 505                 510         


Thr Thr Asp Thr Tyr Leu Leu Gly Glu Pro Val Leu Pro Lys Asn Ser 
        515                 520                 525             


Leu Leu Tyr Gln Gln Phe Thr Val Leu Asn Glu Leu Asn Lys Leu Lys 
    530                 535                 540                 


Val Asn Gly Lys Ala Leu Thr Val Asp Gln Lys Lys Tyr Leu Tyr Glu 
545                 550                 555                 560 


His Val Cys Lys Lys Gln Arg Arg Val Thr Leu Lys Lys Leu Ser Asp 
                565                 570                 575     


Cys Leu Met Ala Arg Gly Asp Phe Pro Met Gly Ala Ile Phe Thr Gly 
            580                 585                 590         


Thr Thr Asp Gln Lys Asn Met Asn Asn Thr Leu Lys Thr Tyr Gln Asp 
        595                 600                 605             


Phe Gln Glu Ile Phe Gly Asp Glu Ile Asp Asn Pro Asp Arg Gln Val 
    610                 615                 620                 


Asp Phe Glu Lys Met Ile Glu Trp Ser Ala Ile Phe Glu Asp Arg Glu 
625                 630                 635                 640 


Ile Phe Lys Leu Lys Leu Ala Glu Leu Asn Trp Leu Thr Ser Glu Gln 
                645                 650                 655     


Leu Glu Arg Val Ser Lys Lys Arg Tyr Gln Gly Trp Gly Arg Leu Ser 
            660                 665                 670         


Gln Lys Leu Leu Thr His Ile Val Asn Glu Asn Gly Glu Arg Ile Ile 
        675                 680                 685             


Asp Gln Leu Trp Asn Thr Asn Gln Asn Phe Met Glu Ile Met Gly Gln 
    690                 695                 700                 


Asp Ser Val Lys Gln Ala Ile Gln Glu His Asn Gly Ala Asn Val Ala 
705                 710                 715                 720 


Gln Thr Gly Ile Asn Glu Thr Ile Asp Glu Leu Tyr Thr Ser Pro Gln 
                725                 730                 735     


Asn Lys Lys Ala Ile Arg Gln Ile Leu Leu Val Val Asp Asp Ile Lys 
            740                 745                 750         


Lys Ala Val Gly Tyr Ala Pro Ala Asn Ile Met Met Glu Phe Ala Arg 
        755                 760                 765             


Glu Asp Arg Asp Asp His Arg Leu Ile Ala Ser Arg Ala Arg Gln Leu 
    770                 775                 780                 


Glu Lys Thr Tyr Gln Glu Ile Ser Lys Asn Trp Phe Asp Asn Glu Ser 
785                 790                 795                 800 


Val Thr Gln Glu Leu Lys Asp Gln Ile Lys Asn Lys Thr Lys Phe Thr 
                805                 810                 815     


Asp Arg Leu Tyr Leu Tyr Phe Ile Gln Gly Gly Ile Asp Leu Tyr Thr 
            820                 825                 830         


Gly His Pro Leu Asn Ile Asp Gln Leu Ser Ser Tyr Asp Ile Asp His 
        835                 840                 845             


Ile Leu Pro Gln Ser Phe Leu Leu Asp Asn Ser Leu Asn Asn Arg Val 
    850                 855                 860                 


Leu Thr Ser Gln Ala Glu Asn Arg Val His Lys Glu Asp Arg Leu Pro 
865                 870                 875                 880 


Gly Glu Thr Val Ala Asn Lys Met Arg Pro Thr Trp Lys Met Met Arg 
                885                 890                 895     


Glu Gln Gly Leu Met Thr Gln Arg Lys Tyr Asn Asn Leu Thr Leu Lys 
            900                 905                 910         


Pro Asp Gln Ile Ser Lys Phe Asn Asn Arg Gly Gln Phe Ile Asn Arg 
        915                 920                 925             


Gln Leu Val Glu Thr Arg Gln Val Ile Lys Leu Ala Ala Asp Ile Met 
    930                 935                 940                 


Ser Gln Lys Tyr Gln Ala Asp Gln Thr Lys Val Val Thr Val Lys Ala 
945                 950                 955                 960 


Asn Leu Thr His His Met Arg Glu Lys Phe Asn Phe Tyr Lys Ser Arg 
                965                 970                 975     


Asn Val Asn Asp Tyr His His Ala Phe Asp Ala Tyr Leu Thr Leu Phe 
            980                 985                 990         


Val Gly Asn Trp Leu Leu Lys Glu  Tyr Pro Lys Leu Gln  Pro Tyr Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Phe Ala Lys  Thr Gly Thr Asn Asn  Leu Lys Ser 
    1010                 1015                 1020             


Phe Asn  Phe Leu Tyr Arg Phe  Glu Arg Asp His Lys  Leu Asn Asp 
    1025                 1030                 1035             


Lys Gly  Ala Ile Asp Thr Asp  Lys Asp Gln Gln Leu  Gly Tyr Met 
    1040                 1045                 1050             


Lys Arg  Ile Tyr Arg Phe Lys  Lys Met Leu Val Thr  Lys Gln Leu 
    1055                 1060                 1065             


Glu Thr  Asn Glu Gly Ala Leu  Tyr Gly Gln Thr Leu  Tyr Pro Ala 
    1070                 1075                 1080             


Pro Lys  Asn Asp Lys Lys Thr  Arg Asn Leu Ile Asn  Ser Lys Lys 
    1085                 1090                 1095             


Asn Arg  Pro Ser Asp Ile Tyr  Gly Gly Tyr Ser Asn  Glu Asn Gly 
    1100                 1105                 1110             


Ser Phe  Leu Thr Leu Val Lys  Leu Lys Lys Gly Ser  Lys Tyr Asp 
    1115                 1120                 1125             


Tyr Arg  Leu Val Ala Val Pro  Val Ser Lys Ile Ser  Glu Ile Lys 
    1130                 1135                 1140             


Glu Ser  Glu Leu Ala Thr Ile  Glu Lys Ala Ile Ala  Pro Gln Phe 
    1145                 1150                 1155             


Leu Lys  Ser Ser Gly Lys Tyr  Arg Asp Phe Gln Val  Val Leu Ser 
    1160                 1165                 1170             


Lys Ile  Leu Ile Asn Gln Lys  Val Ile Asp Asp Gly  Met Ile Phe 
    1175                 1180                 1185             


Thr Ile  Gly Ser Lys Ser Tyr  Lys His Asn Ala Lys  Gln Val Val 
    1190                 1195                 1200             


Leu Ser  Asp Asn Ser Ile Gln  Ile Val Ser Thr Leu  Ser Arg Ile 
    1205                 1210                 1215             


Ser Asp  Lys Glu Lys Leu Ile  Thr Val Phe Asp Glu  Ile Val Asp 
    1220                 1225                 1230             


Ile Thr  Ser Lys Tyr Leu Pro  Trp Tyr Lys Val Asn  Asp Val Glu 
    1235                 1240                 1245             


Lys Thr  Lys Met Leu Phe Arg  Gln Met Gln Asp Ile  Asp Glu Met 
    1250                 1255                 1260             


Lys Lys  Ile Ile Asp Asn Ser  Leu Ile Gly Leu His  Cys Asn Ala 
    1265                 1270                 1275             


Ser Ile  Thr Asp Leu Gly Lys  Val Gly Leu Ser Lys  Tyr Trp Gly 
    1280                 1285                 1290             


Arg Phe  Val Leu Thr Ala Gly  Ile Ser Leu Thr Val  Asp Ala Gln 
    1295                 1300                 1305             


Leu Ile  Tyr Gln Ser Pro Thr  Gly Leu Phe Glu His  Arg Val Lys 
    1310                 1315                 1320             


Val Ser  Asp Leu 
    1325         


<210> 283
<211> 1391
<212> PRT
<213> Lactobacillus gasseri


<220>
<223> Lactobacillus gasseri JV-V03

<400> 283
Met Thr Lys Ile Lys Asn Glu Tyr Ile Val Gly Leu Asp Val Gly Thr 
1               5                   10                  15      


Asn Ser Cys Gly Trp Val Ala Met Asp Phe Gln Asn Thr Ile Leu Arg 
            20                  25                  30          


Met His Gly Lys Thr Ala Ile Gly Ser His Leu Phe Asp Ala Gly Asn 
        35                  40                  45              


Ser Ala Ala Asp Arg Arg Ala Phe Arg Thr Thr Arg Arg Arg Ile Lys 
    50                  55                  60                  


Arg Arg Lys Trp Arg Leu Lys Leu Leu Glu Glu Ile Phe Asp Pro Tyr 
65                  70                  75                  80  


Met Thr Glu Val Asp Pro Tyr Phe Phe Ala Arg Leu Lys Glu Ser Gly 
                85                  90                  95      


Leu Ser Pro Leu Asp Lys Arg Lys Asn Val Ser Ser Ile Val Phe Pro 
            100                 105                 110         


Thr Ala Leu Glu Asp Lys Lys Phe Tyr Cys Asn Tyr Pro Thr Ile Tyr 
        115                 120                 125             


His Leu Arg Tyr Asp Leu Met Ser Glu Asp Lys Lys Phe Asp Leu Arg 
    130                 135                 140                 


Glu Ile Tyr Leu Ala Ile His His Ile Val Lys Tyr Arg Gly Asn Phe 
145                 150                 155                 160 


Leu Tyr Asn Thr Pro Val Lys Asp Phe Glu Ala Ser Lys Ile Asp Val 
                165                 170                 175     


Lys Asp Ser Leu Glu Lys Leu Asn Glu Leu Tyr Glu Arg Leu Asp Ser 
            180                 185                 190         


Glu Phe Thr Val Glu Leu Asp Ser Ser Asn Ala Leu Glu Ile Glu Lys 
        195                 200                 205             


Ile Ile Arg Asp Lys Lys Val Phe Lys Ile Asn Lys Val Lys Ser Ile 
    210                 215                 220                 


His Gln Leu Leu Ser Leu Lys Thr Glu Asn Lys Glu Arg Thr Lys Leu 
225                 230                 235                 240 


Ile Lys Asp Val Ser Lys Gln Ile Ile Asn Ala Ile Leu Gly Tyr Lys 
                245                 250                 255     


Thr Lys Phe Glu Thr Ile Leu Leu Lys Asn Ile Ser Lys Asp Glu Ala 
            260                 265                 270         


Asp Asp Trp Glu Phe Lys Leu Thr Asp Val Asp Ala Asp Asn Lys Phe 
        275                 280                 285             


Glu Asn Leu Ile Gly Asp Leu Asn Glu Asn Glu Gln Glu Ile Leu Leu 
    290                 295                 300                 


Glu Ile Arg Asn Leu Ala Asn Ala Ile Thr Leu Ser Asn Ile Val Glu 
305                 310                 315                 320 


Glu Gly Lys Thr Leu Ser Glu Ser Met Ile Asp Lys Tyr Asn Lys His 
                325                 330                 335     


Ser Asp Asp Leu Glu Leu Leu Lys Gln Val Ile Ser Asp His Pro Asp 
            340                 345                 350         


Arg Asp Lys Ala Lys Lys Leu Ala Leu Ala Tyr Asp Leu Tyr Val Asn 
        355                 360                 365             


Asn Arg His Gly Lys Leu Leu Gln Ala Lys Asp Val Leu Gly Ser Lys 
    370                 375                 380                 


Lys Thr Leu Ser Lys Glu Asp Phe Tyr Lys Glu Val Lys Lys Asn Leu 
385                 390                 395                 400 


Asp Asp Ser Lys Ala Ser Gln Glu Ile Leu Asp Thr Ile Ala Leu Asp 
                405                 410                 415     


Ser Phe Met Pro Lys Gln Arg Thr Asn Glu Asn Gly Val Ile Pro Tyr 
            420                 425                 430         


Gln Leu His Gln Leu Glu Leu Asp Arg Ile Ile Lys Asn Gln Gly Lys 
        435                 440                 445             


Tyr Tyr Pro Phe Leu Lys Glu Val Asn Pro Val Ser Ser His Leu Lys 
    450                 455                 460                 


Glu Ala Pro Tyr Lys Leu Asp Glu Leu Ile Arg Phe Arg Val Pro Tyr 
465                 470                 475                 480 


Tyr Val Gly Pro Leu Ile Ser Pro Asn Glu Ser Thr Lys Asn Lys Gln 
                485                 490                 495     


Thr Lys Lys Asn Gln Asn Phe Ala Trp Met Ile Arg Lys Glu Gln Gly 
            500                 505                 510         


Gln Ile Thr Pro Trp Asn Phe Asp Gln Lys Val Asp Arg Met Ala Ser 
        515                 520                 525             


Ala Asn Lys Phe Ile Lys Arg Met Thr Thr Lys Asp Thr Tyr Leu Leu 
    530                 535                 540                 


Gly Glu Asp Val Leu Pro Ala Asn Ser Leu Leu Tyr Gln Lys Phe Thr 
545                 550                 555                 560 


Val Leu Asn Glu Leu Asn Asn Ile Lys Ile Asn Gly Lys Arg Ile Ser 
                565                 570                 575     


Val Pro Leu Lys Glu Glu Leu Tyr Asn Asn Leu Phe Lys Lys Asn Ser 
            580                 585                 590         


Thr Val Thr Thr Asn Lys Leu Lys Ser Tyr Leu Lys Glu Asn Tyr Asn 
        595                 600                 605             


Leu Ile Asn Val Glu Ile Lys Gly Leu Ala Asp Glu Lys Lys Phe Asn 
    610                 615                 620                 


Ser Gly Leu Thr Thr Tyr Asn Lys Leu Arg Asn Leu Lys Ile Phe Asp 
625                 630                 635                 640 


Gln Gln Leu Asp Asp Leu Asn Tyr Asp Lys Asp Phe Glu Arg Ile Ile 
                645                 650                 655     


Glu Trp Ser Thr Ile Phe Glu Asp Lys Ala Ile Tyr Lys Asp Lys Leu 
            660                 665                 670         


Lys Thr Ile Lys Trp Leu Ser Asp Arg Gln Ile Asp Lys Leu Ser Lys 
        675                 680                 685             


Ile Arg Met Gln Gly Trp Gly Gln Leu Ser Lys Lys Leu Leu Ser Gln 
    690                 695                 700                 


Leu Thr Asp Asn Asn Gly Gln Thr Ile Ile Glu Gln Leu Trp Asp Ser 
705                 710                 715                 720 


Gln Asn Asn Phe Met Gln Ile Val Asn Gln Ser Asp Phe Lys Asp Ala 
                725                 730                 735     


Ile Ala Val Ala Asn Gln Asn Leu Leu Val Asn Thr Ser Val Glu Asp 
            740                 745                 750         


Ile Leu Asn Glu Ala Tyr Thr Ser Pro Ala Asn Lys Lys Ala Ile Arg 
        755                 760                 765             


Gln Val Val Lys Val Val Asp Asp Ile Val Lys Ala Ala Ser Gly Lys 
    770                 775                 780                 


Val Pro Lys Gln Ile Ala Ile Glu Phe Thr Arg Asp Ala Asp Asp Lys 
785                 790                 795                 800 


Ala Lys Ile Ser Gln Thr Arg Ala Asn Lys Leu Arg Lys Val Tyr Lys 
                805                 810                 815     


Glu Leu Ser Asn Glu Leu Ala Ser Glu Thr Ile Arg Asn Glu Leu Glu 
            820                 825                 830         


Arg Val Ala Lys Asp Gln Lys Leu Leu Lys Asp Lys Tyr Tyr Leu Tyr 
        835                 840                 845             


Phe Met Gln Leu Gly Arg Asp Ala Tyr Thr Gly Glu Pro Ile Asn Ile 
    850                 855                 860                 


Asp Asp Leu Gly Gln Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Phe 
865                 870                 875                 880 


Ile Lys Asp Asp Ser Leu Glu Asn Arg Val Leu Val Lys Lys Ala Val 
                885                 890                 895     


Asn Asn Gly Lys Ser Asp Asn Val Pro Val Lys Leu Tyr Gly Asn Arg 
            900                 905                 910         


Met Ala Ala Asp Leu Gly Met Thr Ile Arg His Met Trp Glu Lys Trp 
        915                 920                 925             


Lys Asp Gln Gly Leu Ile Thr Lys Thr Lys Tyr Asn Asn Leu Ile Ile 
    930                 935                 940                 


Asp Pro Asp Lys Ile Asn Lys Tyr Glu Ser Ser Gly Phe Ile His Arg 
945                 950                 955                 960 


Gln Leu Val Glu Thr Ser Gln Ile Ile Lys Leu Val Ser Thr Ile Leu 
                965                 970                 975     


Gln Ser Lys Tyr Pro Asp Thr Glu Ile Ile Val Val Lys Ala Arg Tyr 
            980                 985                 990         


Asn His Tyr Leu Arg Lys His Leu  Asn Leu Tyr Lys Ser  Arg Glu Val 
        995                 1000                 1005             


Asn Asp  Tyr His His Ala Ile  Asp Ala Tyr Leu Ser  Ala Ile Cys 
    1010                 1015                 1020             


Gly Asn  Leu Leu Tyr Gln Val  Tyr Pro Tyr Leu Arg  Pro Phe Phe 
    1025                 1030                 1035             


Val Tyr  Gly Gln Tyr Lys Lys  Phe Ser Ser Asp Pro  Lys Lys Glu 
    1040                 1045                 1050             


Lys Ile  Ile Tyr Asp Lys Thr  Arg Lys Tyr Asn Phe  Ile Ser Gln 
    1055                 1060                 1065             


Ile Phe  Glu Asn Lys Ser Asn  Asp Ile Ile Ser Leu  Glu Thr Lys 
    1070                 1075                 1080             


Lys Lys  Val Phe Asp Lys Lys  Asp Ile Ile Glu Lys  Leu Lys His 
    1085                 1090                 1095             


Ala Tyr  Asn Tyr Lys Tyr Met  Leu Val Ser Arg Glu  Thr Glu Thr 
    1100                 1105                 1110             


His Asp  Gln Glu Met Phe Lys  Met Thr Val Tyr Pro  Arg Leu Ser 
    1115                 1120                 1125             


Arg Asp  Thr Lys Lys Ser Arg  Asn Leu Ile Ser Lys  Lys Lys Asp 
    1130                 1135                 1140             


Met Pro  Thr Glu Ile Tyr Gly  Gly Tyr Thr Asn Asn  Ser Asp Ala 
    1145                 1150                 1155             


Tyr Met  Val Ile Ala Arg Ile  Asn Lys Lys Lys Gly  Thr Glu Tyr 
    1160                 1165                 1170             


Arg Val  Phe Gly Val Pro Met  Arg Glu Leu Val Asn  Leu Arg Lys 
    1175                 1180                 1185             


Ala Glu  Lys Asn Gly Arg Tyr  Asn Ala Tyr Leu Lys  Gln Val Leu 
    1190                 1195                 1200             


Glu Pro  Glu Ile Met Tyr Ser  Lys Asn Gly Lys Lys  Asn Lys Thr 
    1205                 1210                 1215             


Ile Ser  Ser Phe Glu Ile Val  Lys Ala Lys Val Pro  Tyr Lys Gln 
    1220                 1225                 1230             


Val Ile  Leu Asp Gly Asp Lys  Lys Phe Met Leu Ala  Ser Ser Thr 
    1235                 1240                 1245             


Tyr Val  Gln Asn Ala Lys Gln  Leu Thr Leu Ser Gln  Asn Ser Met 
    1250                 1255                 1260             


Gln Ala  Ile Thr Asp Asn Cys  Glu Asn Asp Thr Glu  Glu Glu Lys 
    1265                 1270                 1275             


Ala Leu  Glu Glu Lys Ala Leu  Ile Glu Ala Tyr Asp  Glu Ile Leu 
    1280                 1285                 1290             


Thr Asn  Ile Asp Lys Tyr Leu  Pro Leu Phe Asp Ile  Asn Lys Phe 
    1295                 1300                 1305             


Arg Glu  Lys Leu His Ala Gly  Arg Glu Lys Phe Ile  Asn Leu Ser 
    1310                 1315                 1320             


Leu Asp  Val Lys Lys Asp Thr  Ile Leu Gln Val Leu  Asn Gly Leu 
    1325                 1330                 1335             


His Asp  Asn Ala Val Met Pro  Lys Ile Lys Ser Leu  Gly Leu Ser 
    1340                 1345                 1350             


Thr Pro  Leu Gly Phe Met Gln  Phe Ser Ser Gly Val  Pro Leu Ser 
    1355                 1360                 1365             


Glu Asn  Ala Lys Leu Ile Tyr  Gln Ser Pro Thr Gly  Leu Phe Glu 
    1370                 1375                 1380             


Lys Arg  Val Lys Ile Ser Asp  Leu 
    1385                 1390     


<210> 284
<211> 1386
<212> PRT
<213> Lactobacillus hominis


<220>
<223> Lactobacillus hominis CRBIP 24.179

<400> 284
Met Thr Lys Ile Thr Glu Asp Tyr Ile Val Gly Leu Asp Ile Gly Thr 
1               5                   10                  15      


Asn Ser Cys Gly Trp Val Ala Met Asp Ser Lys Asn Thr Ile Leu Arg 
            20                  25                  30          


Met His Gly Lys Thr Ala Ile Gly Ser His Leu Phe Asp Ala Gly Asn 
        35                  40                  45              


Ser Ala Ala Asp Arg Arg Ala Phe Arg Thr Thr Arg Arg Arg Ile Lys 
    50                  55                  60                  


Arg Arg Lys Trp Arg Leu Lys Leu Leu Glu Glu Ile Phe Asp Ser His 
65                  70                  75                  80  


Leu Ala Lys Val Asp Pro Tyr Phe Phe Ala Arg Leu Lys Glu Ser Gly 
                85                  90                  95      


Leu Ser Pro Leu Asp Thr Arg Lys Asn Val Ser Ser Ile Ile Tyr Pro 
            100                 105                 110         


Thr Ser Leu Glu Asp Lys Lys Phe Tyr Val Asp Asn Pro Thr Ile Tyr 
        115                 120                 125             


His Leu Arg Tyr Lys Leu Met Thr Glu Asp Arg Lys Phe Asp Leu Arg 
    130                 135                 140                 


Glu Val Tyr Leu Ala Ile His His Ile Val Lys Tyr Arg Gly Asn Phe 
145                 150                 155                 160 


Leu Tyr Asn Thr Pro Val Lys Ala Phe Glu Ala Ser Lys Ile Asp Val 
                165                 170                 175     


Lys Gly Ser Leu Lys Lys Leu Asn Glu Leu Tyr Glu Gly Leu Asp Ser 
            180                 185                 190         


Glu Phe Asn Val Glu Leu Asp Ser Asn Asn Ala Leu Glu Ile Glu Asn 
        195                 200                 205             


Ile Ile Arg Asp Lys Lys Ile Phe Lys Ile Asn Lys Val Lys Glu Ile 
    210                 215                 220                 


Asn Gln Leu Leu Ser Leu Lys Thr Glu Asp Lys Glu Arg Thr Lys Leu 
225                 230                 235                 240 


Met Lys Asp Val Ser Lys Gln Ile Val Asn Ala Ile Leu Gly Tyr Lys 
                245                 250                 255     


Thr Lys Phe Glu Thr Ile Leu Leu Lys Asp Val Ser Lys Asp Glu Ala 
            260                 265                 270         


Asp Asp Trp Glu Phe Lys Leu Thr Asp Val Asp Ala Asp Asn Lys Phe 
        275                 280                 285             


Glu Asn Leu Ile Gly Asp Leu Asn Glu Asn Glu Gln Glu Ile Leu Leu 
    290                 295                 300                 


Val Ile Arg Lys Leu Ala Asn Ala Ile Thr Leu Ser Asn Ile Val Glu 
305                 310                 315                 320 


Glu Gly Lys Thr Leu Ser Glu Ser Met Lys Asp Lys Tyr Lys Lys His 
                325                 330                 335     


Ser Asp Asp Leu Lys Leu Leu Lys Gln Val Ile Ser Asp His Pro Asp 
            340                 345                 350         


Arg Asp Lys Ala Lys Lys Leu Ala Leu Ala Tyr Asp Leu Tyr Val Asn 
        355                 360                 365             


Asn Arg His Gly Lys Ile Leu Gln Ala Lys Asp Ile Leu Glu Lys Lys 
    370                 375                 380                 


Lys Thr Leu Ser Lys Glu Asp Phe Tyr Lys Glu Ile Lys Lys Asn Leu 
385                 390                 395                 400 


Asp Asp Ser Lys Glu Ser Gln Glu Ile Leu Asp Ala Ile Ser Leu Asp 
                405                 410                 415     


Ser Phe Met Pro Lys Gln Arg Thr Asn Glu Asn Gly Val Ile Pro Tyr 
            420                 425                 430         


Gln Leu His Gln Leu Glu Leu Asp Lys Ile Ile Glu Asn Gln Gly Lys 
        435                 440                 445             


Tyr Tyr Pro Phe Leu Lys Glu Val Asn Pro Val Ser Ser His Leu Lys 
    450                 455                 460                 


Gln Ala Pro Tyr Lys Leu Asp Glu Leu Ile Arg Phe Arg Val Pro Tyr 
465                 470                 475                 480 


Tyr Val Gly Pro Leu Ile Ser Pro Asn Glu Ser Thr Lys Asn Lys Gln 
                485                 490                 495     


Thr Lys Lys Asn Gln Asn Phe Ala Trp Met Ile Arg Lys Glu Gln Gly 
            500                 505                 510         


Gln Ile Thr Pro Trp Asn Phe Asp Gln Lys Val Asp Arg Met Ala Ser 
        515                 520                 525             


Ala Asn Lys Phe Ile Lys Arg Met Thr Thr Ile Asp Thr Tyr Leu Leu 
    530                 535                 540                 


Gly Glu Asp Val Leu Pro Ala Asn Ser Leu Leu Tyr Gln Lys Phe Thr 
545                 550                 555                 560 


Val Leu Asn Glu Leu Asn Asn Val Lys Ile Asn Gly Lys Arg Ile Ser 
                565                 570                 575     


Val Pro Leu Lys Gln Glu Leu Tyr Asn Asn Leu Phe Lys Lys Asn Ser 
            580                 585                 590         


Thr Val Thr Thr Asn Lys Leu Lys Ser Tyr Leu Lys Glu Asn Tyr Lys 
        595                 600                 605             


Leu Ile Lys Val Glu Ile Lys Gly Leu Ser Asp Glu Lys Lys Phe Asn 
    610                 615                 620                 


Ser Gly Leu Thr Thr Tyr Asn Lys Leu Lys Asn Leu Lys Ile Phe Asp 
625                 630                 635                 640 


Gln Gln Ile Asp Asp Pro Asn Tyr Asn Lys Asp Phe Glu Arg Ile Ile 
                645                 650                 655     


Glu Trp Ser Thr Ile Phe Glu Asp Lys Ala Ile Tyr Lys Glu Lys Leu 
            660                 665                 670         


Lys Thr Ile Asp Trp Leu Ser Asp Arg Gln Ile Asp Lys Leu Ser Lys 
        675                 680                 685             


Ile Arg Met Gln Gly Trp Gly Gln Leu Ser Lys Lys Leu Leu Ser Gln 
    690                 695                 700                 


Leu Thr Asp Asn Asn Gly Gln Thr Ile Ile Glu Gln Leu Trp Asp Ser 
705                 710                 715                 720 


Gln Asn Asn Phe Met Gln Ile Val Asn Gln Ala Asp Phe Lys Asp Ala 
                725                 730                 735     


Ile Ala Val Ala Asn Gln Asn Leu Leu Val Asp Thr Ser Val Glu Asp 
            740                 745                 750         


Ile Leu Asn Glu Ala Tyr Thr Ser Pro Ala Asn Lys Lys Ala Ile Arg 
        755                 760                 765             


Gln Val Val Lys Val Val Asp Asp Ile Val Lys Ala Thr Ser Gly Lys 
    770                 775                 780                 


Val Pro Lys Gln Ile Ala Ile Glu Phe Thr Arg Asp Ala Asp Asp Asn 
785                 790                 795                 800 


Ala Lys Ile Ser Gln Ser Arg Ala Asn Lys Leu Arg Lys Val Tyr Lys 
                805                 810                 815     


Glu Met Ser Asn Glu Leu Ala Ser Glu Thr Ile Arg Asn Glu Leu Glu 
            820                 825                 830         


Arg Val Ala Lys Asp Gln Lys Leu Leu Lys Asp Lys His Tyr Leu Tyr 
        835                 840                 845             


Phe Met Gln Leu Gly Arg Asp Ala Tyr Thr Gly Glu Leu Ile Asp Ile 
    850                 855                 860                 


Asp Asn Leu Glu Gln Tyr Asp Ile Asp His Val Leu Pro Gln Ser Phe 
865                 870                 875                 880 


Ile Lys Asp Asp Ser Leu Glu Asn Arg Val Leu Val Lys Lys Ala Val 
                885                 890                 895     


Asn Asn Gly Lys Ser Asp Asn Val Pro Val Lys Leu Tyr Gly Asn Arg 
            900                 905                 910         


Met Ala Thr Asp Leu Gly Met Thr Ile Arg His Met Trp Glu Lys Trp 
        915                 920                 925             


Lys Glu Gln Gly Leu Ile Thr Lys Thr Lys Tyr Asn Asn Leu Ile Ile 
    930                 935                 940                 


Asp Pro Asp Lys Ile Asn Lys Tyr Glu Ser Ser Gly Phe Ile His Arg 
945                 950                 955                 960 


Gln Leu Val Glu Thr Ser Gln Ile Ile Lys Leu Val Ser Thr Ile Leu 
                965                 970                 975     


Gln Ser Lys Tyr Pro Asp Thr Glu Ile Ile Val Val Lys Ala Arg Tyr 
            980                 985                 990         


Asn His Tyr Leu Arg Lys Arg Leu  Asn Leu Tyr Lys Ser  Arg Glu Val 
        995                 1000                 1005             


Asn Asp  Tyr His His Ala Ile  Asp Ala Tyr Leu Ser  Ala Ile Cys 
    1010                 1015                 1020             


Gly Asn  Leu Leu Tyr Gln Val  Tyr Pro Tyr Leu Arg  Pro Phe Phe 
    1025                 1030                 1035             


Val Tyr  Gly Gln Tyr Lys Lys  Phe Ser Ser Glu Pro  Glu Lys Glu 
    1040                 1045                 1050             


Lys Ile  Ile Tyr Asp Lys Thr  Arg Arg Tyr Asn Phe  Ile Ser Gln 
    1055                 1060                 1065             


Ile Phe  Glu Asn Lys Asp Asn  Asp Ile Ile Ser Arg  Glu Thr Lys 
    1070                 1075                 1080             


Lys Lys  Val Phe Asp Lys Lys  Asp Ile Ile Glu Lys  Leu Lys Arg 
    1085                 1090                 1095             


Ala Tyr  Asn Tyr Lys Tyr Met  Leu Val Ser Arg Glu  Thr Glu Thr 
    1100                 1105                 1110             


His Asp  Gln Glu Met Phe Lys  Met Thr Val Tyr Pro  Arg Leu Ser 
    1115                 1120                 1125             


Arg Asp  Thr Lys Lys Ser Arg  Asn Leu Ile Pro Lys  Lys Lys Asp 
    1130                 1135                 1140             


Met Pro  Thr Glu Ile Tyr Gly  Gly Tyr Thr Asn Asn  Ser Asp Ala 
    1145                 1150                 1155             


Tyr Met  Ile Ile Ala Arg Ile  Asn Lys Lys Lys Gly  Pro Glu Tyr 
    1160                 1165                 1170             


Arg Val  Phe Gly Val Pro Met  Arg Glu Leu Val Asn  Leu Arg Lys 
    1175                 1180                 1185             


Ala Glu  Lys Asn Gly His Tyr  Lys Ala Tyr Leu Lys  Gln Val Leu 
    1190                 1195                 1200             


Glu Pro  Glu Ile Met Tyr Ser  Lys Asn Gly Lys Lys  Asn Lys Thr 
    1205                 1210                 1215             


Ile Ser  Ser Phe Glu Ile Val  Lys Ala Lys Val Pro  Tyr Lys Gln 
    1220                 1225                 1230             


Val Ile  Leu Asp Gly Asp Lys  Lys Phe Met Leu Ala  Ser Ser Thr 
    1235                 1240                 1245             


Tyr Val  Gln Asn Ala Lys Gln  Leu Thr Leu Ser Gln  Tyr Ser Met 
    1250                 1255                 1260             


Gln Ala  Ile Thr Asp Asn Cys  Glu Asn Asp Thr Glu  Glu Glu Lys 
    1265                 1270                 1275             


Ala Leu  Val Glu Ala Tyr Asp  Glu Ile Leu Thr Asn  Ile Asp Lys 
    1280                 1285                 1290             


Tyr Leu  Pro Leu Phe Asp Ile  Asn Lys Phe Arg Glu  Lys Leu His 
    1295                 1300                 1305             


Ala Gly  Arg Glu Lys Phe Val  Asp Leu Pro Leu Ala  Glu Lys Lys 
    1310                 1315                 1320             


Glu Thr  Ile Leu Gln Val Leu  Asn Gly Leu His Asp  Asn Ala Val 
    1325                 1330                 1335             


Met Pro  Lys Ile Lys Ser Leu  Gly Leu Ser Thr Pro  Leu Gly Phe 
    1340                 1345                 1350             


Met Gln  Phe His Thr Gly Val  Ser Leu Ser Glu Asn  Ala Lys Leu 
    1355                 1360                 1365             


Ile Tyr  Gln Ser Pro Thr Gly  Leu Phe Glu Lys Arg  Leu Lys Ile 
    1370                 1375                 1380             


Ser Asp  Leu 
    1385     


<210> 285
<211> 1369
<212> PRT
<213> Lactobacillus iners


<220>
<223> Lactobacillus iners LactinV 11V1-d

<400> 285
Met Asn Asn Asn Tyr Tyr Leu Gly Leu Asp Leu Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Thr Asp Asp His Tyr Asn Ile Ile Lys Phe His Gly 
            20                  25                  30          


Lys His Met Trp Gly Met Arg Leu Phe Glu Glu Ala Glu Thr Ala Lys 
        35                  40                  45              


Asp Arg Arg Leu His Arg Gln Ala Arg Arg Arg Arg Gln Arg Leu Val 
    50                  55                  60                  


Glu Arg Ile Asn Leu Leu Glu Glu Leu Phe Asp Lys Glu Ile Ser Lys 
65                  70                  75                  80  


Val Asp Gln Gly Phe Phe Ala Arg Lys Lys Glu Ser Asp Leu His Phe 
                85                  90                  95      


Glu Asp Lys Thr Thr Lys Ser Glu Tyr Ala Leu Phe Asn Asp Lys Ser 
            100                 105                 110         


Tyr Thr Asp Arg Asp Tyr Tyr Lys Gln Tyr Pro Thr Ile Phe His Leu 
        115                 120                 125             


Ile Met Asp Leu Ile Glu Asn Asp Lys Lys Arg Asp Ile Arg Leu Val 
    130                 135                 140                 


Tyr Leu Ala Cys His Tyr Leu Ile Lys His Arg Gly His Phe Ile Phe 
145                 150                 155                 160 


Asp Gly Lys Asn Phe Thr Val Asp Asn Ser Phe Glu Asn Leu Leu Asp 
                165                 170                 175     


Lys Leu Ile Thr Tyr Leu Lys Asp Asn Asp Asp Ile Thr Leu Ser Phe 
            180                 185                 190         


Pro Lys Asp Gln Leu Ile Asn Ile Phe Lys Asn Ser Asn Leu Asn Ser 
        195                 200                 205             


Thr Glu Lys Ser Asp Gln Leu Lys Pro Phe Phe Gly Arg Thr Asn Leu 
    210                 215                 220                 


Glu Lys Gly Ile Ile Lys Leu Leu Ser Gly Gly Lys Gln Asp Leu Ser 
225                 230                 235                 240 


Asn Met Phe Arg Asp Glu Thr Leu Lys Asn Ser Asn Tyr Lys Asn Leu 
                245                 250                 255     


Lys Phe Ser Asp Asn Arg Phe Asp Asp Glu Arg Asp Gly Tyr Ala Ala 
            260                 265                 270         


Asp Leu Gly Asp Arg Ile Asp Leu Leu Ile Leu Leu Lys Gln Ile Tyr 
        275                 280                 285             


Asp Ala Ser Ile Leu Glu Ser Met Met Ser Gln Ala Arg Val Ser Ile 
    290                 295                 300                 


Asp Gly His Lys Tyr Ile Ser Ser Ala Lys Val Cys Ala Tyr Glu Lys 
305                 310                 315                 320 


His Lys Ser Asp Leu Lys Arg Leu Lys Ser Leu Ile Lys Lys Tyr Leu 
                325                 330                 335     


Pro Ser Glu Tyr Asn Asn Ile Phe Arg Lys Ile Thr Glu Lys Asp Asn 
            340                 345                 350         


Tyr Val Ala Tyr Ser Lys Ser Asn Ile Thr Asn Asn Lys Arg Glu Lys 
        355                 360                 365             


Ala Leu Lys Tyr Val Lys Tyr Val Asp Phe Thr Lys Tyr Leu Thr Lys 
    370                 375                 380                 


Lys Leu Lys Thr Ile Lys Thr Gln Asp Ala Glu Asp Asp Gln Glu Ile 
385                 390                 395                 400 


Phe Glu Ile Lys Gly Glu Leu Glu Lys Gln Ser Phe Leu Pro Lys Gln 
                405                 410                 415     


Arg Thr Leu Asp Asn Ser Ile Ile Pro Tyr Gln Leu His Leu Met Glu 
            420                 425                 430         


Leu Lys Lys Ile Leu Asp Asn Gln Ser Lys Tyr Tyr Asp Phe Leu Leu 
        435                 440                 445             


Ala Lys Asp Asp Gln Glu Gly Ile Thr Val Lys Asp Lys Ile Ile Ser 
    450                 455                 460                 


Leu Leu Thr Phe Arg Leu Pro Tyr Tyr Ile Gly Pro Val Asn Pro Ala 
465                 470                 475                 480 


Val His Gly Lys Phe Ala Trp Val Lys Arg Leu Ala Asn Gly Lys Val 
                485                 490                 495     


Thr Pro Trp Asn Tyr Lys Glu Lys Ile Asp Ile Asp Ala Ser His Glu 
            500                 505                 510         


Glu Phe Ile Lys Thr Lys Leu Ser Lys Cys Ser Phe Leu Ile Gly Cys 
        515                 520                 525             


Asp Val Leu Pro Lys Asn Ser Leu Leu Tyr Gln Lys Tyr Met Val Leu 
    530                 535                 540                 


Ser Glu Leu Asn Thr Ile Lys Phe Asn Gly Val Asn Ile Ser Glu Lys 
545                 550                 555                 560 


Leu Lys Asp Asp Ile Tyr Gln Asn Leu Phe Lys Asn Ile Gln Lys Val 
                565                 570                 575     


Thr Lys Lys Arg Leu Gln Asn Tyr Ile Lys Glu His Glu Asn Ile Ile 
            580                 585                 590         


Gly Asp Val Ile Val Thr Gly Ile Asp Asn Ala Phe Lys Gln Gly Leu 
        595                 600                 605             


Val Ser Tyr Leu Lys Phe Lys Lys Ile Ile Gly Asp Lys Val Asp Asp 
    610                 615                 620                 


Asp Arg Tyr Gln Lys Val Leu Glu Lys Ile Ile Arg Asp Ile Thr Leu 
625                 630                 635                 640 


Tyr Asp Glu Cys Ala Gly Lys Lys Ile Lys Lys Glu Tyr Lys Asp Ser 
                645                 650                 655     


Asp Leu Phe Thr Glu Asp Glu Leu Asn Lys Ile Val Lys Leu Thr Phe 
            660                 665                 670         


Asn Asp Trp Gly Arg Leu Ser Ala Glu Leu Leu Asp Gln Leu Glu Gly 
        675                 680                 685             


Glu Asp Thr Val Ser Gly Glu Thr Gly Lys Ile Ile Glu Phe Met Gln 
    690                 695                 700                 


Lys His Asn Tyr Asn Leu Met Gln Leu Met Ser Lys Lys Phe Thr Phe 
705                 710                 715                 720 


Lys Ser Lys Ile Asp Glu Ile Asn Lys Ser Tyr Tyr Gln His Asp Lys 
                725                 730                 735     


Phe Asn Tyr Lys Ser Met Ile Asp Ser Leu Tyr Val Ser Pro Ala Thr 
            740                 745                 750         


Lys Arg Ile Leu Trp Gln Ser Leu Lys Val Val His Glu Ile Ser Lys 
        755                 760                 765             


Ile Met Lys His Asp Pro Glu Lys Ile Phe Ile Glu Met Ala Arg Ser 
    770                 775                 780                 


Lys Glu Asp His Pro Lys Arg Lys Leu Ser Arg Lys Ala Asp Leu Lys 
785                 790                 795                 800 


Gln Val Tyr Lys Asp Ser Lys Lys Gln Ile Ile Ser Ile Ile Gly Lys 
                805                 810                 815     


Asp Lys Tyr Gln Asp Leu Ser Asn Glu Leu Asp Asn Lys Asp Asp Arg 
            820                 825                 830         


Asp Leu Arg Trp Asp Asn Leu Tyr Leu Tyr Tyr Thr Gln Leu Gly Arg 
        835                 840                 845             


Ser Met Tyr Ser Leu Lys Pro Ile Asp Ile Ser Glu Leu Met Asn Lys 
    850                 855                 860                 


Asn Leu Tyr Asp Gln Asp His Ile Phe Pro Lys Ser Lys Lys Tyr Asp 
865                 870                 875                 880 


Asp Ser Ile Glu Asn Arg Val Leu Val Glu Lys Glu Leu Asn Val Lys 
                885                 890                 895     


Lys Ser Asp Ile Tyr Pro Ile Ser Asp Ala Asn Ile Ile Pro Gln Lys 
            900                 905                 910         


Ile Lys Gly Gln Val Glu Ser Phe Trp Lys Met Leu Tyr Asp His Lys 
        915                 920                 925             


Leu Ile Gly Asp Lys Lys Tyr Ala Arg Leu Ile Arg Ser Lys Ala Phe 
    930                 935                 940                 


Thr Asp Asp Glu Leu Ala Gly Phe Ile Ala Arg Gln Leu Val Glu Thr 
945                 950                 955                 960 


Arg Gln Ala Thr Lys Glu Thr Ala Asp Leu Leu Lys Arg Leu Cys Pro 
                965                 970                 975     


Lys Ser Arg Ile Val Tyr Ala Lys Ala Gln Asn Ala Ser Ile Phe Arg 
            980                 985                 990         


Gln Lys Phe Asp Ile Pro Lys Ser  Arg Thr Ile Asn Asp  Leu His His 
        995                 1000                 1005             


Ala Gln  Asp Ala Tyr Leu Asn  Ile Val Val Gly Asn  Ile Phe Asp 
    1010                 1015                 1020             


Thr Lys  Phe Thr Gln Asp Pro  Arg Asn Phe Ile Lys  Asn Thr Lys 
    1025                 1030                 1035             


Asp Ser  Arg Asn Tyr Asn Leu  Glu Lys Ile Tyr Asp  Tyr Asn Val 
    1040                 1045                 1050             


Glu Arg  Asn Asn Tyr Val Ala  Trp Ile Ala Pro Asp  Gly Glu Thr 
    1055                 1060                 1065             


Asn Gly  Thr Ile Ala Asn Val  Lys Cys Asn Leu Ser  Thr Lys Asp 
    1070                 1075                 1080             


Phe Arg  Val Thr Arg Pro Ser  Phe Tyr Lys Lys Gly  Ala Leu Phe 
    1085                 1090                 1095             


Asn Gln  Asn Leu Ser Arg Lys  Gly Ser Asn Leu Ala  Pro Ile Lys 
    1100                 1105                 1110             


Glu His  Ser Pro Lys Ser Asn  Pro Leu Lys Tyr Gly  Gly Tyr Ser 
    1115                 1120                 1125             


Gly Lys  Asn Asn Ser Phe Phe  Val Val Val Ala Gly  Lys Asp Asn 
    1130                 1135                 1140             


Lys Gly  Lys Asp Ile Val Lys  Leu Ile Pro Val Asn  Thr Leu Ile 
    1145                 1150                 1155             


Tyr Asn  Lys Met Leu His Cys  Asp Tyr Lys Ala Lys  Gln Glu Leu 
    1160                 1165                 1170             


Leu Thr  Ser Tyr Val Ala Asn  Asn Phe Ala Ile Asn  Asn Phe Arg 
    1175                 1180                 1185             


Ile Val  Lys Asp Asp Ile Lys  Met Tyr Ser Leu Val  Lys Ile Asp 
    1190                 1195                 1200             


Gly Ala  Tyr Tyr Tyr Leu Val  Gly Gly Thr Asp Glu  Arg Ile Glu 
    1205                 1210                 1215             


Val Lys  Asn Ala Met Gln Leu  Leu Leu Ser Lys Asp  Ser Ile Lys 
    1220                 1225                 1230             


Ala Val  Lys Ile Leu Glu Lys  Glu Ser Lys Asp Gln  Phe Ala Asn 
    1235                 1240                 1245             


Ile Lys  Asn Tyr Lys Asp Ile  Asp Ile Lys Leu Gly  Arg Thr Phe 
    1250                 1255                 1260             


Asn Glu  Val Val Ser Lys Tyr  Thr Asn Ser Val Phe  Gly Lys Ser 
    1265                 1270                 1275             


Met Leu  Ile Ser Asp Lys Tyr  Arg Lys Asp Ile Phe  Lys Ser Val 
    1280                 1285                 1290             


Glu Lys  Ser Ile Leu Glu Phe  Asn His Leu Asp Thr  Ile Gly Lys 
    1295                 1300                 1305             


Ala Asp  Asn Leu Leu Lys Phe  Val Thr Leu Met Arg  Pro Ser Gly 
    1310                 1315                 1320             


Ser Ala  His Ser Leu Lys Met  Val Gly Leu Ile Glu  Arg Ile Arg 
    1325                 1330                 1335             


Lys Ser  Asn Val Ile Ser Asn  Phe Asn Glu Phe Lys  Leu Ile Asn 
    1340                 1345                 1350             


Gln Ser  Val Thr Gly Leu Phe  Glu Asn Glu Glu Asp  Leu Leu Lys 
    1355                 1360                 1365             


Leu 
    


<210> 286
<211> 1391
<212> PRT
<213> Lactobacillus jensenii


<220>
<223> Lactobacillus jensenii 269-3

<400> 286
Met Lys Glu Ile Lys Asp Tyr Ile Ile Gly Leu Asp Ile Gly Thr Asn 
1               5                   10                  15      


Ser Cys Gly Tyr Val Val Thr Asp Lys Gln Asn Asn Ile Leu Lys Leu 
            20                  25                  30          


Lys Gly Lys Thr Ala Ile Gly Ala Arg Leu Phe Lys Glu Gly Glu Ala 
        35                  40                  45              


Ala Ala Asp Arg Arg Ala Phe Arg Thr Thr Arg Arg Arg Leu Ala Arg 
    50                  55                  60                  


Arg Arg Trp Arg Leu Ser Leu Leu Glu Glu Ile Phe Asp Glu Glu Met 
65                  70                  75                  80  


Asn Lys Val Asp Pro Ser Phe Phe Arg Arg Leu Lys Glu Ser Asp Tyr 
                85                  90                  95      


Ser Pro Lys Asp Arg Arg Lys Gln Phe Asn Ser Ile Val Phe Glu Ser 
            100                 105                 110         


Ser Glu Ala Asp Lys Ala Phe Tyr Glu Lys Tyr Pro Thr Ile Tyr His 
        115                 120                 125             


Leu Arg Asn Ala Leu Met His Asp Asn Gln Lys His Asp Leu Arg Glu 
    130                 135                 140                 


Ile Phe Leu Ala Val His His Ile Val Lys Tyr Arg Gly Asn Phe Leu 
145                 150                 155                 160 


Arg Glu Asp Ser Val Lys Ala Phe Lys Ala Ala Lys Phe Thr Leu Gln 
                165                 170                 175     


Gly Glu Asp Gly Ile Gly Pro Val Asp Lys Leu Asn Asp Leu Leu Lys 
            180                 185                 190         


Glu Ile Tyr Ile Glu Ala Ala Pro Glu Leu Ala Thr Asp Asn Leu Ser 
        195                 200                 205             


Lys Ile Glu Asp Ile Ile Lys Asp Lys Lys Leu Tyr Lys Gln Asp Lys 
    210                 215                 220                 


Leu Lys Gln Ile Ala Asn Leu Leu Pro Lys Ala Val Asp Ser Lys Asp 
225                 230                 235                 240 


Lys Ala Lys Leu Asn Lys Asp Ile Ala Lys Gln Val Ala Asn Ala Leu 
                245                 250                 255     


Met Gly Tyr Met Phe Arg Leu Asp Thr Leu Phe Ser Phe Thr Asp Val 
            260                 265                 270         


Asp Val Lys Asp Tyr Lys Leu Lys Phe Ser Asp Ala Asn Ile Asp Glu 
        275                 280                 285             


Ser Leu Asp Ala Leu Thr Ser Leu Leu Thr Asp Ala Gln Ile Glu Phe 
    290                 295                 300                 


Val Leu Glu Leu Gln Ser Ile Tyr Asn Thr Ile Val Leu Asn Glu Ile 
305                 310                 315                 320 


Val Pro Asp Gly Met Ser Leu Ser Glu Ser Met Val Lys Lys Tyr Asp 
                325                 330                 335     


Asp His Lys Lys Asp Leu Lys Leu Tyr Lys Glu Tyr Ile Asp Ser Leu 
            340                 345                 350         


Ser Asp Gln Lys Lys Ala Lys Gln Leu Glu Ala Ala Tyr Ala Leu Tyr 
        355                 360                 365             


Val Asn Tyr Arg Lys Ala Asp Leu Leu Ala Ala Lys Lys Leu Phe Glu 
    370                 375                 380                 


Lys Lys Lys Ile Gly Asp Lys Lys Phe Val Asp Val Ile Ser Asn Phe 
385                 390                 395                 400 


Glu Val Phe Gly Lys Phe Val Ser Asp Asn Leu Asp Asp Ser Glu Leu 
                405                 410                 415     


Ala Asn Lys Ile Lys Ala Arg Leu Asp Leu Gly Glu Phe Leu Pro Lys 
            420                 425                 430         


Gln Arg Thr Asn Gln Asn Gly Val Ile Pro Tyr Gln Leu His Gln Val 
        435                 440                 445             


Glu Leu Thr Gln Ile Leu Glu Lys Gln Gly Lys Tyr Tyr Pro Phe Leu 
    450                 455                 460                 


Ile Thr Pro Asn Pro Val Glu Ser His Arg Asn Asn Ala Pro Tyr Glu 
465                 470                 475                 480 


Ile Ser Glu Leu Val Ser Phe Arg Val Pro Tyr Tyr Val Gly Pro Leu 
                485                 490                 495     


Ile Asp Asn Gln Ser Ile Lys Asp Lys Gln Asn Lys Asn Lys Phe Ala 
            500                 505                 510         


Trp Met Val Arg Gln Lys Gln Gly Gln Ile Thr Pro Trp Asn Phe Glu 
        515                 520                 525             


Glu Met Val Asp Thr Thr Glu Ser Ala Asn Gln Phe Ile Lys Arg Met 
    530                 535                 540                 


Thr Arg Lys Asp Thr Tyr Leu Leu Ala Glu Asp Val Leu Pro Lys Ser 
545                 550                 555                 560 


Ser Leu Ile Tyr Gln Lys Phe Met Ile Leu Asp Glu Leu Asn Arg Ile 
                565                 570                 575     


Lys Ile Asp Gly Lys Lys Leu Thr Ser Lys Leu Lys His Asp Ile Phe 
            580                 585                 590         


Glu Lys Leu Phe Lys Lys Gln Lys Ser Ile Asn Leu Asp Asn Leu Lys 
        595                 600                 605             


Asn Tyr Leu Leu Ala Glu Gly Asn Ile Pro Gly Leu Ile Glu Gly Leu 
    610                 615                 620                 


Ser Asp Gly Ile Asn Phe Asn Asn Ser Phe Ser Thr Tyr Ile Asp Tyr 
625                 630                 635                 640 


Arg Asn Ile Phe Gly Asp Glu Ile Asp Asn Pro Asn Lys Gln Ala Asp 
                645                 650                 655     


Phe Glu Lys Met Ile Glu Trp Ser Thr Val Phe Glu Asp Arg Lys Ile 
            660                 665                 670         


Phe Lys Arg Lys Leu Lys Glu Ile Thr Trp Leu Thr Pro Glu Gln Ile 
        675                 680                 685             


Lys Gln Val Ser Ser Lys Arg Tyr Ser Gly Trp Gly Arg Leu Ser Lys 
    690                 695                 700                 


Lys Leu Leu Thr Gln Ile Thr Asp Glu Asn Gly Val Asn Ile Leu Gln 
705                 710                 715                 720 


Arg Leu Trp Asn Glu Pro Glu Thr Leu Thr Glu Val Leu Ala Asn Pro 
                725                 730                 735     


Val Ile Lys Arg Lys Ile Ser Glu Ala Asn Ser Leu Phe Val Gln Ile 
            740                 745                 750         


Asn Lys Val Glu Asn Ile Leu Asp Asp Ala Tyr Thr Ser Pro Gln Asn 
        755                 760                 765             


Lys Lys Ala Ile Arg Gln Val Ile Arg Val Val Asp Asp Ile Ile Ala 
    770                 775                 780                 


Ala Ala His Gly Lys Lys Pro Ser Gln Ile Ala Ile Glu Phe Ala Arg 
785                 790                 795                 800 


Ser Ser Gln Asn Lys Ala Lys Val Pro Asp Thr Arg Lys Lys Gln Leu 
                805                 810                 815     


Asp Lys Ile Tyr Asn Lys Ile Ser Ser Glu Ile Leu Asp Ser Ser Ile 
            820                 825                 830         


Lys Asn Glu Leu Lys Asn Leu Lys Ser Asn Lys Tyr Leu Ser Lys Asp 
        835                 840                 845             


Lys Leu Phe Leu Tyr Phe Lys Gln Met Gly Arg Asp Ala Tyr Thr Gly 
    850                 855                 860                 


Asp Lys Leu Ser Leu Asp Gln Leu Gln Asn Tyr Asp Ile Asp His Ile 
865                 870                 875                 880 


Phe Pro Arg Ser Phe Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu 
                885                 890                 895     


Thr Gln Lys Pro Ile Asn Ala Lys Lys Ser Asp Tyr Gly Ile Pro Ala 
            900                 905                 910         


Leu Glu Phe Gly Asn Lys Tyr Val Pro Asp Leu Gly Ile Thr Val Lys 
        915                 920                 925             


Glu Met Trp Lys Leu Trp Gln Glu Asn Gly Leu Ile Ser Lys Ser Lys 
    930                 935                 940                 


Leu Ile Asn Leu Cys Thr Asn Pro Lys Lys Ile Gly Ser Lys Arg Ala 
945                 950                 955                 960 


Ser Gly Phe Ile Asn Arg Gln Leu Val Glu Thr Ser Gln Val Ile Lys 
                965                 970                 975     


Leu Val Ala Ile Ile Leu Gln Ala Glu Phe Pro Asp Thr Glu Ile Ile 
            980                 985                 990         


Glu Val Lys Ala Leu Gln Asn Thr  Thr Leu Arg Glu Ser  Phe His Leu 
        995                 1000                 1005             


Tyr Lys  Asn Arg Ser Val Asn  Asp Tyr His His Ala  Ile Asp Ala 
    1010                 1015                 1020             


Tyr Leu  Thr Thr Ile Val Gly  Asn Tyr Leu Tyr Gln  Val Tyr Pro 
    1025                 1030                 1035             


Lys Leu  Arg Pro Tyr Phe Val  Tyr Gly Gln Phe Lys  Lys Phe Asn 
    1040                 1045                 1050             


Gln Glu  Lys Asn Ile Asp Ile  Leu Lys Arg Leu Lys  Asn Phe Asn 
    1055                 1060                 1065             


Phe Leu  Arg Gln Leu Ile Phe  Asn Thr Asp Asp Asn  Ile Tyr Ile 
    1070                 1075                 1080             


Ser Gly  Thr Lys Glu Ile Val  Phe Asn Lys Lys Asp  Ile Ile His 
    1085                 1090                 1095             


Lys Leu  Glu Thr Ala Tyr Gly  Tyr Lys Tyr Met Asn  Ile Ser Arg 
    1100                 1105                 1110             


Glu Cys  Tyr Gln Glu Thr Ser  Ser Leu Phe Asn Gln  Thr Leu Tyr 
    1115                 1120                 1125             


Ala His  Asn Ser Ser Val Lys  Asn Ser Leu Ile Pro  Lys Lys Lys 
    1130                 1135                 1140             


Gly Leu  Pro Thr Glu Ile Tyr  Gly Gly Tyr Ser Gly  Asn Lys Asp 
    1145                 1150                 1155             


Ser Phe  Phe Val Leu Val Lys  Ile Val Lys Lys Arg  Thr Asn Leu 
    1160                 1165                 1170             


Tyr Arg  Ile Val Gly Ile Pro  Thr Arg Glu Leu Ala  Lys Leu Asn 
    1175                 1180                 1185             


Ser Ser  Asn Asn Tyr Asn Gln  Ala Leu Asn Lys Ile  Val Glu Ser 
    1190                 1195                 1200             


Lys Leu  Cys Leu Lys Glu Thr  Glu Ser Phe Lys Ile  Leu Ile Lys 
    1205                 1210                 1215             


Arg Leu  Leu Tyr Gly Thr Leu  Ile Val Asp Asn Gly  Gln Lys Phe 
    1220                 1225                 1230             


Arg Ile  Gly Ser Phe Lys Glu  Lys His Asn Val Gln  Gln Leu Val 
    1235                 1240                 1245             


Leu Gln  Leu Lys Ser Met Lys  Tyr Ile Lys Phe Tyr  Ile Asp Gly 
    1250                 1255                 1260             


Gly Gln  Asn Tyr Phe Thr Asp  Val Glu Arg Lys Lys  Leu Glu Lys 
    1265                 1270                 1275             


Gln Asp  Arg Asp Lys Cys Leu  Leu Tyr Val Phe Asp  Asp Ile Met 
    1280                 1285                 1290             


Asn Val  Val Asn Lys Arg Phe  Thr Leu Phe Asp Met  Ser Lys Tyr 
    1295                 1300                 1305             


Glu Lys  Asp Gly Asp Ser Leu  Arg Glu Lys Phe Asn  Cys Leu Asp 
    1310                 1315                 1320             


Phe Asn  Asp Lys Val Ser Ile  Leu Ser Asp Leu Leu  Lys Ala Phe 
    1325                 1330                 1335             


His Ala  Asn Ser Asp Arg Thr  Ser Ile Thr Lys Leu  Lys Ile Thr 
    1340                 1345                 1350             


Asn Leu  Gly Arg His Gln Ala  Gly Lys Asn Gly Ile  Thr Leu Thr 
    1355                 1360                 1365             


Thr Asn  Ala Gln Ile Ile Tyr  Gln Ser Pro Thr Gly  Leu Phe Glu 
    1370                 1375                 1380             


Arg Arg  Ile Lys Ile Lys Asp  Leu 
    1385                 1390     


<210> 287
<211> 1395
<212> PRT
<213> Lactobacillus jensenii


<220>
<223> Lactobacillus jensenii 27-2-CHN

<400> 287
Met Lys Glu Ile Lys Asp Tyr Ile Ile Gly Leu Asp Ile Gly Thr Asn 
1               5                   10                  15      


Ser Cys Gly Tyr Val Val Thr Asp Lys Gln Asn Asn Ile Leu Lys Leu 
            20                  25                  30          


Lys Gly Lys Thr Ala Ile Gly Ala Arg Leu Phe Lys Glu Gly Gln Ala 
        35                  40                  45              


Ala Ala Asp Arg Arg Ser Phe Arg Thr Thr Arg Arg Arg Leu Ala Arg 
    50                  55                  60                  


Arg His Trp Arg Leu Gly Leu Leu Glu Glu Ile Phe Asp Pro Glu Met 
65                  70                  75                  80  


Glu Lys Ile Asp Pro Asn Phe Phe Arg Arg Leu Lys Glu Ser Asp Tyr 
                85                  90                  95      


Ser Pro Lys Asp Ser Arg Lys Gln Phe Asn Ala Ile Val Phe Lys Ser 
            100                 105                 110         


Ile Lys Ala Asp Lys Arg Phe Tyr Lys Lys Tyr Pro Thr Ile Tyr His 
        115                 120                 125             


Leu Arg Asn Ala Leu Met His Asp Asn Gln Lys His Asp Leu Arg Glu 
    130                 135                 140                 


Ile Phe Met Ala Val His His Ile Val Lys Tyr Arg Gly Asn Phe Leu 
145                 150                 155                 160 


Arg Glu Asp Ser Val Asn Ala Phe Lys Ala Ala Lys Phe Ser Leu Arg 
                165                 170                 175     


Gly Glu Asp Gly Ile Gly Pro Val Asp Lys Leu Asn Asp Leu Leu Lys 
            180                 185                 190         


Glu Ile Tyr Ser Glu Tyr Ser Pro Glu Leu Ala Thr Asn Asn Leu Ser 
        195                 200                 205             


Lys Ile Glu Asp Ile Ile Lys Asp Lys Asn Leu Tyr Lys Gln Asp Lys 
    210                 215                 220                 


Leu Lys Gln Val Ala Thr Leu Leu Ile Lys Glu Ala Asp Ser Lys Asp 
225                 230                 235                 240 


Lys Ala Lys Leu Asn Lys Asp Ile Ala Lys Gln Val Ala Asn Ser Phe 
                245                 250                 255     


Met Gly Tyr Met Phe Arg Leu Asp Thr Leu Phe Ser Leu Thr Asp Val 
            260                 265                 270         


Asp Val Lys Asp Tyr Lys Leu Lys Phe Ser Asp Ala Asn Ile Asp Glu 
        275                 280                 285             


Ser Leu Asp Asp Leu Thr Ser Leu Leu Thr Asp Ala Gln Ile Glu Phe 
    290                 295                 300                 


Val Leu Glu Leu Gln Ser Ile Tyr Asn Thr Ile Val Leu Asn Glu Ile 
305                 310                 315                 320 


Val Pro Asp Gly Met Ser Leu Ser Glu Ser Met Ile Lys Lys Tyr Asp 
                325                 330                 335     


Asp His Lys Glu Asp Leu Lys Ile Phe Lys Glu Tyr Ile Asp Ser Leu 
            340                 345                 350         


Ser Asp Gln Lys Lys Ala Lys Lys Leu Leu Ser Ala Tyr Asn Leu Tyr 
        355                 360                 365             


Val Asn Tyr Arg Lys Ser Asp Leu Val Glu Ala Lys Asn Leu Phe Lys 
    370                 375                 380                 


Asn Lys Lys Val Gly Asp Lys Asn Phe Ala Asp Val Ile Ser Asn Phe 
385                 390                 395                 400 


Glu Val Phe Gly Lys Phe Val Ser Asp Asn Leu Asp Asp Ser Glu Leu 
                405                 410                 415     


Ala Asn Lys Ile Lys Ala Arg Leu Asp Leu Gly Glu Phe Leu Pro Lys 
            420                 425                 430         


Gln Arg Thr Asn Gln Asn Gly Val Ile Pro Tyr Gln Leu His Gln Val 
        435                 440                 445             


Glu Leu Thr Gln Ile Leu Glu Lys Gln Gly Lys Tyr Tyr Pro Phe Leu 
    450                 455                 460                 


Ile Thr Pro Asn Pro Val Glu Ser His Arg Asn Asn Ala Pro Tyr Glu 
465                 470                 475                 480 


Ile Ser Glu Leu Val Ser Phe Arg Val Pro Tyr Tyr Val Gly Pro Leu 
                485                 490                 495     


Ile Asp Asn Gln Ser Ile Lys Asp Lys Gln Asn Lys Asn Lys Phe Ala 
            500                 505                 510         


Trp Met Val Arg Gln Lys Gln Gly Gln Ile Thr Pro Trp Asn Leu Glu 
        515                 520                 525             


Glu Met Val Asp Thr Thr Glu Ser Ala Asn Gln Phe Ile Lys Arg Met 
    530                 535                 540                 


Thr Arg Lys Asp Thr Tyr Leu Leu Ala Glu Asp Val Leu Pro Lys Ser 
545                 550                 555                 560 


Ser Leu Val Tyr Gln Lys Phe Met Ile Leu Asp Glu Leu Asn Arg Ile 
                565                 570                 575     


Lys Ile Asp Gly Lys Lys Leu Thr Ser Glu Leu Lys His Asp Ile Phe 
            580                 585                 590         


Glu Lys Leu Phe Lys Lys Gln Lys Ser Ile Asn Leu Asp Asn Leu Lys 
        595                 600                 605             


Asn Tyr Leu Leu Val Glu Gly Asn Ile Pro Gly Leu Ile Glu Gly Leu 
    610                 615                 620                 


Ser Asp Gly Ile Asn Phe Asn Asn Ser Phe Ser Thr Tyr Ile Asp Tyr 
625                 630                 635                 640 


Arg Asn Ile Phe Gly Asp Glu Ile Asp Asn Pro Asn Lys Gln Ala Asp 
                645                 650                 655     


Phe Glu Lys Met Ile Glu Trp Ser Thr Val Phe Glu Asp Arg Lys Ile 
            660                 665                 670         


Phe Lys Arg Lys Leu Lys Glu Ile Thr Trp Leu Thr Ser Glu Gln Ile 
        675                 680                 685             


Lys Gln Val Ser Ser Lys Arg Tyr Ser Gly Trp Gly Arg Leu Ser Lys 
    690                 695                 700                 


Lys Leu Leu Thr Gln Ile Thr Asp Glu Asn Gly Val Asn Ile Leu Gln 
705                 710                 715                 720 


Arg Leu Trp Asn Glu Pro Glu Thr Leu Thr Glu Val Leu Ala Asn Pro 
                725                 730                 735     


Val Ile Lys Arg Lys Ile Val Glu Ala Asn Ser Ser Phe Thr Lys Ala 
            740                 745                 750         


Lys Asp Met Lys Asp Ile Leu Val Glu Ala Tyr Thr Ser Pro Gln Asn 
        755                 760                 765             


Lys Lys Ala Ile Arg Gln Val Met Arg Val Val Asp Asp Ile Ile Ala 
    770                 775                 780                 


Ala Ala His Gly Lys Lys Pro Ser Gln Ile Ala Ile Glu Phe Ala Arg 
785                 790                 795                 800 


Glu Asp Gln Asp Asn Pro Gln Met Thr Lys Ser Arg Lys Ala Gln Leu 
                805                 810                 815     


Asp Gln Ile Tyr Ala Lys Ile Ser Asp Glu Phe Leu Asp Asp Ala Val 
            820                 825                 830         


Lys Asn Glu Leu Lys Asn Met Lys Asp Asn Lys Pro Leu Ala Lys Asp 
        835                 840                 845             


Lys Val Phe Leu Tyr Phe Lys Gln Met Gly Arg Asp Ala Tyr Ser Gly 
    850                 855                 860                 


Glu Lys Leu Ser Leu Asp Asn Leu Gln Asp Tyr Asp Ile Asp His Ile 
865                 870                 875                 880 


Tyr Pro Gln Ser Phe Ile Lys Asp Asp Ser Phe Asp Asn Arg Val Leu 
                885                 890                 895     


Val Gln Arg Ala Tyr Asn Asn Gly Lys Ser Asp Asn Val Pro Val Leu 
            900                 905                 910         


Leu Phe Gly Asn Lys Ile Ala Ala Gly Leu Gly Ile Thr Ile Arg Gln 
        915                 920                 925             


Met Trp Lys Lys Trp Leu Glu Leu Gly Leu Ile Ser Lys Arg Lys Phe 
    930                 935                 940                 


Asn Asn Leu Ile Thr Asp Pro Glu Lys Ile Ser Arg Asn Met Ala Ser 
945                 950                 955                 960 


Gly Phe Val Asn Arg Gln Leu Val Glu Thr Ser Gln Val Ile Lys Leu 
                965                 970                 975     


Val Ala Asn Ile Leu Gln Ala Lys Leu Pro Asp Thr Glu Ile Ile Glu 
            980                 985                 990         


Val Lys Ala Ser Tyr Asn Ser Ile  Leu Arg Lys Glu Phe  Asn Leu Tyr 
        995                 1000                 1005             


Lys Ser  Arg Glu Val Asn Asp  Tyr His His Ala Ile  Asp Ala Tyr 
    1010                 1015                 1020             


Leu Thr  Thr Ile Val Gly Asn  Tyr Leu Tyr Gln Val  Tyr Pro Lys 
    1025                 1030                 1035             


Leu Arg  Pro Tyr Phe Val Tyr  Gly Gln Phe Lys Lys  Phe Gly Lys 
    1040                 1045                 1050             


Ala Glu  Asn Gln Glu Asp Asp  Pro Val Lys Lys Ile  Lys Lys Phe 
    1055                 1060                 1065             


Asn Phe  Ile Tyr Gln Leu Ile  Trp Gly Lys Asp Asp  Ala Ile Cys 
    1070                 1075                 1080             


Ile Ser  His Thr Asn Gln Gln  Val Phe Ser Lys Lys  Asp Ile Ile 
    1085                 1090                 1095             


Asp Lys  Leu Thr Thr Ala Tyr  Asn Phe Lys Tyr Met  Asn Ile Ser 
    1100                 1105                 1110             


His Ala  Val Tyr Thr Arg Asn  Asn Asn Met Phe Lys  Gln Thr Leu 
    1115                 1120                 1125             


Phe Pro  Ile Ile Glu Arg Thr  Thr Ala Lys Thr Lys  Ser Leu Ile 
    1130                 1135                 1140             


Pro Lys  Lys Leu Asp Arg Pro  Thr Asp Ile Tyr Gly  Gly Tyr Ser 
    1145                 1150                 1155             


Asn Asn  Asn Asp Ala Tyr Leu  Ala Leu Val Lys Val  Asp Lys Lys 
    1160                 1165                 1170             


Arg Gly  Ser Glu Tyr Arg Val  Val Gly Ile Pro Met  Arg Ala Ala 
    1175                 1180                 1185             


Ala Met  Leu Lys Ala Ser Lys  Asn Tyr Asp Glu Asp  Leu Arg Lys 
    1190                 1195                 1200             


Val Ile  Glu Pro Met Val Met  Phe Asp Lys Asn Gly  Lys Ala Lys 
    1205                 1210                 1215             


Arg Gly  Ile Glu Gly Phe Arg  Val Leu Val Gly Lys  Met Pro Phe 
    1220                 1225                 1230             


Lys Gln  Ala Val Leu Asp Gly  Asn Lys Lys Phe Met  Leu Thr Gly 
    1235                 1240                 1245             


Thr Val  Asp Thr Pro Asn Leu  Lys Gln Leu Val Leu  Ser Gln Gln 
    1250                 1255                 1260             


Asn Met  Lys Tyr Ile Leu Asp  Tyr Ile Glu Asp Val  Asp Cys Arg 
    1265                 1270                 1275             


Lys His  Lys Phe Gly Asp Lys  Val Gln Asn Pro Asp  Lys Cys Leu 
    1280                 1285                 1290             


Leu Glu  Val Phe Asp Glu Ile  Ile Glu Ile Val Asp  Lys Tyr Phe 
    1295                 1300                 1305             


Glu Leu  Phe Asp Ser Arg Asp  Phe Arg Glu Lys Leu  Arg Asn Ser 
    1310                 1315                 1320             


Arg Asn  Lys Phe Ile Lys Leu  Glu Ala Ser Lys Lys  Ala Asp Thr 
    1325                 1330                 1335             


Ile Leu  Ala Ile Leu Lys Gly  Leu Gln Ala Lys Ser  Thr Arg Ala 
    1340                 1345                 1350             


Thr Ile  Lys Glu Leu Asn Ile  Ser Asp Phe Gly Arg  Ile Ile Thr 
    1355                 1360                 1365             


Ser Ser  Ile Ser Pro Glu Ala  Gln Leu Ile Tyr Gln  Ser Pro Thr 
    1370                 1375                 1380             


Gly Leu  Phe Glu Arg Arg Val  Lys Val Lys Asp Leu  
    1385                 1390                 1395 


<210> 288
<211> 1375
<212> PRT
<213> Lactobacillus johnsonii

<400> 288
Met Thr Lys Ile Lys Asp Asp Tyr Ile Val Gly Leu Asp Ile Gly Thr 
1               5                   10                  15      


Asp Ser Cys Gly Trp Val Ala Met Asn Ser Asn Asn Asp Ile Leu Lys 
            20                  25                  30          


Leu Gln Gly Lys Thr Ala Ile Gly Ser Arg Leu Phe Glu Gly Gly Lys 
        35                  40                  45              


Ser Ala Ala Glu Arg Arg Leu Phe Arg Thr Thr His Arg Arg Ile Lys 
    50                  55                  60                  


Arg Arg Arg Trp Arg Leu Lys Leu Leu Glu Glu Phe Phe Asp Pro Tyr 
65                  70                  75                  80  


Met Ala Glu Val Asp Pro Tyr Phe Phe Ala Arg Leu Lys Glu Ser Gly 
                85                  90                  95      


Leu Ser Pro Leu Asp Lys Arg Lys Thr Val Ser Ser Ile Val Phe Pro 
            100                 105                 110         


Thr Ser Ala Glu Asp Lys Lys Phe Tyr Asp Asp Tyr Pro Thr Ile Tyr 
        115                 120                 125             


His Leu Arg Tyr Lys Leu Met Thr Glu Asp Glu Lys Phe Asp Leu Arg 
    130                 135                 140                 


Glu Val Tyr Leu Ala Ile His His Ile Ile Lys Tyr Arg Gly Asn Phe 
145                 150                 155                 160 


Leu Tyr Asn Thr Ser Val Lys Asp Phe Lys Ala Ser Lys Ile Asp Val 
                165                 170                 175     


Lys Ser Ser Ile Glu Lys Leu Asn Glu Leu Tyr Glu Asn Leu Gly Leu 
            180                 185                 190         


Asp Leu Asn Val Glu Phe Asn Ile Ser Asn Thr Ala Glu Ile Glu Lys 
        195                 200                 205             


Val Leu Lys Asp Lys Gln Ile Phe Lys Arg Asp Lys Val Lys Lys Ile 
    210                 215                 220                 


Ala Glu Leu Phe Ala Ile Lys Thr Asp Asn Lys Glu Gln Ser Lys Arg 
225                 230                 235                 240 


Ile Lys Asp Ile Ser Lys Gln Val Ala Asn Ala Val Leu Gly Tyr Lys 
                245                 250                 255     


Thr Arg Phe Asp Thr Ile Ala Leu Lys Glu Ile Ser Lys Asp Glu Leu 
            260                 265                 270         


Ser Asp Trp Asn Phe Lys Leu Ser Asp Ile Asp Ala Asp Ser Lys Phe 
        275                 280                 285             


Glu Ala Leu Met Gly Asn Leu Asp Glu Asn Glu Gln Ala Ile Leu Leu 
    290                 295                 300                 


Thr Ile Lys Glu Leu Phe Asn Glu Val Thr Leu Asn Gly Ile Val Glu 
305                 310                 315                 320 


Asp Gly Asn Thr Leu Ser Glu Ser Met Ile Asn Lys Tyr Asn Asp His 
                325                 330                 335     


Arg Asp Asp Leu Lys Leu Leu Lys Glu Val Ile Glu Asn His Ile Asp 
            340                 345                 350         


Arg Lys Lys Ala Lys Glu Leu Ala Leu Ala Tyr Asp Leu Tyr Val Asn 
        355                 360                 365             


Asn Arg His Gly Gln Leu Leu Gln Ala Lys Lys Lys Leu Gly Lys Ile 
    370                 375                 380                 


Lys Pro Arg Ser Lys Glu Asp Phe Tyr Lys Val Val Asn Lys Asn Leu 
385                 390                 395                 400 


Asp Asp Ser Arg Ala Ser Lys Glu Ile Lys Lys Lys Ile Glu Leu Asp 
                405                 410                 415     


Ser Phe Met Pro Lys Gln Arg Thr Asn Ala Asn Gly Val Ile Pro Tyr 
            420                 425                 430         


Gln Leu Gln Gln Leu Glu Leu Asp Lys Ile Ile Glu Asn Gln Ser Lys 
        435                 440                 445             


Tyr Tyr Pro Phe Leu Lys Glu Ile Asn Pro Val Ser Ser His Leu Lys 
    450                 455                 460                 


Glu Ala Pro Tyr Lys Leu Asp Glu Leu Ile Arg Phe Arg Val Pro Tyr 
465                 470                 475                 480 


Tyr Val Gly Pro Leu Ile Ser Pro Asn Glu Ser Thr Lys Asp Ile Gln 
                485                 490                 495     


Thr Lys Lys Asn Gln Asn Phe Ala Trp Met Ile Arg Lys Glu Glu Gly 
            500                 505                 510         


Arg Ile Thr Pro Trp Asn Phe Asp Gln Lys Val Asp Arg Ile Glu Ser 
        515                 520                 525             


Ala Asn Lys Phe Ile Lys Arg Met Thr Thr Lys Asp Thr Tyr Leu Phe 
    530                 535                 540                 


Gly Glu Asp Val Leu Pro Ala Asn Ser Leu Leu Tyr Gln Lys Phe Thr 
545                 550                 555                 560 


Val Leu Asn Glu Leu Asn Asn Ile Arg Ile Asn Gly Lys Arg Ile Ser 
                565                 570                 575     


Val Asp Leu Lys Gln Glu Ile Tyr Glu Asn Leu Phe Lys Lys His Thr 
            580                 585                 590         


Thr Val Thr Val Lys Lys Leu Glu Asn Tyr Leu Lys Glu Asn His Asn 
        595                 600                 605             


Leu Val Lys Val Glu Ile Lys Gly Leu Ala Asp Glu Lys Lys Phe Asn 
    610                 615                 620                 


Ser Gly Leu Thr Thr Tyr Asn Arg Phe Lys Asn Leu Asn Ile Phe Asp 
625                 630                 635                 640 


Asn Gln Ile Asp Asp Leu Lys Tyr Arg Asn Asp Phe Glu Lys Ile Ile 
                645                 650                 655     


Glu Trp Ser Thr Ile Phe Glu Asp Lys Ser Ile Tyr Lys Glu Lys Leu 
            660                 665                 670         


Arg Ser Ile Asp Trp Leu Asn Glu Lys Gln Ile Asn Ala Leu Ser Asn 
        675                 680                 685             


Ile Arg Leu Gln Gly Trp Gly Arg Leu Ser Lys Lys Leu Leu Ala Gln 
    690                 695                 700                 


Leu His Asp His Asn Gly Gln Thr Ile Ile Glu Gln Leu Trp Asp Ser 
705                 710                 715                 720 


Gln Asn Asn Phe Met Gln Ile Val Thr Gln Ala Asp Phe Lys Asp Ala 
                725                 730                 735     


Ile Ala Lys Ala Asn Gln Asn Leu Leu Val Ala Thr Ser Val Glu Asp 
            740                 745                 750         


Ile Leu Asn Asn Ala Tyr Thr Ser Pro Ala Asn Lys Lys Ala Ile Arg 
        755                 760                 765             


Gln Val Ile Lys Val Val Asp Asp Ile Val Lys Ala Ala Ser Gly Lys 
    770                 775                 780                 


Val Pro Lys Gln Ile Ala Ile Glu Phe Thr Arg Asp Ala Asp Glu Asn 
785                 790                 795                 800 


Pro Lys Arg Ser Gln Thr Arg Gly Ser Lys Leu Gln Lys Val Tyr Lys 
                805                 810                 815     


Asp Leu Ser Thr Glu Leu Ala Ser Lys Thr Ile Ala Glu Glu Leu Asn 
            820                 825                 830         


Glu Ala Ile Lys Asp Lys Lys Leu Val Gln Asp Lys Tyr Tyr Leu Tyr 
        835                 840                 845             


Phe Met Gln Leu Gly Arg Asp Ala Tyr Thr Gly Glu Pro Ile Asn Ile 
    850                 855                 860                 


Asp Glu Ile Gln Lys Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Phe 
865                 870                 875                 880 


Ile Lys Asp Asp Ala Leu Asp Asn Arg Val Leu Val Ser Arg Ala Val 
                885                 890                 895     


Asn Asn Gly Lys Ser Asp Asn Val Pro Val Lys Leu Phe Gly Asn Glu 
            900                 905                 910         


Met Ala Ala Asn Leu Gly Met Thr Ile Arg Lys Met Trp Glu Glu Trp 
        915                 920                 925             


Lys Asn Ile Gly Leu Ile Ser Lys Thr Lys Tyr Asn Asn Leu Leu Thr 
    930                 935                 940                 


Asp Pro Asp His Ile Asn Lys Tyr Lys Ser Ala Gly Phe Ile Arg Arg 
945                 950                 955                 960 


Gln Leu Val Glu Thr Ser Gln Ile Ile Lys Leu Val Ser Thr Ile Leu 
                965                 970                 975     


Gln Ser Arg Tyr Pro Asn Thr Glu Ile Ile Thr Val Lys Ala Lys Tyr 
            980                 985                 990         


Asn His Tyr Leu Arg Glu Lys Phe  Asp Leu Tyr Lys Ser  Arg Glu Val 
        995                 1000                 1005             


Asn Asp  Tyr His His Ala Ile  Asp Ala Tyr Leu Ser  Ala Ile Cys 
    1010                 1015                 1020             


Gly Asn  Leu Leu Tyr Gln Asn  Tyr Pro Asn Leu Arg  Pro Phe Phe 
    1025                 1030                 1035             


Val Tyr  Gly Gln Tyr Lys Lys  Phe Ser Ser Asp Pro  Asp Lys Glu 
    1040                 1045                 1050             


Lys Ala  Ile Phe Asn Lys Thr  Arg Lys Phe Ser Phe  Ile Ser Gln 
    1055                 1060                 1065             


Leu Leu  Lys Asn Lys Ser Glu  Asn Ser Lys Glu Ile  Ala Lys Lys 
    1070                 1075                 1080             


Leu Lys  Arg Ala Tyr Gln Phe  Lys Tyr Met Leu Val  Ser Arg Glu 
    1085                 1090                 1095             


Thr Glu  Thr Arg Asp Gln Glu  Met Phe Lys Met Thr  Val Tyr Pro 
    1100                 1105                 1110             


Arg Phe  Ser His Asp Thr Val  Lys Ala Pro Arg Asn  Leu Ile Pro 
    1115                 1120                 1125             


Lys Lys  Met Gly Met Ser Pro  Asp Ile Tyr Gly Gly  Tyr Thr Asn 
    1130                 1135                 1140             


Asn Ser  Asp Ala Tyr Met Val  Ile Val Arg Ile Asp  Lys Lys Lys 
    1145                 1150                 1155             


Gly Thr  Glu Tyr Lys Ile Leu  Gly Ile Pro Thr Arg  Glu Leu Val 
    1160                 1165                 1170             


Asn Leu  Lys Lys Ala Glu Lys  Glu Asp His Tyr Lys  Ser Tyr Leu 
    1175                 1180                 1185             


Lys Glu  Ile Leu Thr Pro Arg  Ile Leu Tyr Asn Lys  Asn Gly Lys 
    1190                 1195                 1200             


Arg Asp  Lys Lys Ile Thr Ser  Phe Glu Ile Val Lys  Ser Lys Ile 
    1205                 1210                 1215             


Pro Tyr  Lys Gln Val Ile Gln  Asp Gly Asp Lys Lys  Phe Met Leu 
    1220                 1225                 1230             


Gly Ser  Ser Thr Tyr Val Tyr  Asn Ala Lys Gln Leu  Thr Leu Ser 
    1235                 1240                 1245             


Thr Glu  Ser Met Lys Ala Ile  Thr Asn Asn Phe Asp  Lys Asp Ser 
    1250                 1255                 1260             


Asp Glu  Asn Asp Ala Leu Ile  Lys Ala Tyr Asp Glu  Ile Leu Asp 
    1265                 1270                 1275             


Lys Val  Asp Lys Tyr Leu Pro  Leu Phe Asp Ile Asn  Lys Phe Arg 
    1280                 1285                 1290             


Glu Lys  Leu His Ser Gly Arg  Glu Lys Phe Ile Lys  Leu Ser Leu 
    1295                 1300                 1305             


Glu Asp  Lys Lys Asp Thr Ile  Leu Lys Val Leu Glu  Gly Leu His 
    1310                 1315                 1320             


Asp Asn  Ala Val Met Thr Lys  Ile Pro Thr Ile Gly  Leu Ser Thr 
    1325                 1330                 1335             


Pro Leu  Gly Phe Met Gln Phe  Pro Asn Gly Val Ile  Leu Ser Glu 
    1340                 1345                 1350             


Asn Ala  Lys Leu Ile Tyr Gln  Ser Pro Thr Gly Leu  Phe Lys Lys 
    1355                 1360                 1365             


Ser Val  Lys Ile Ser Asp Leu  
    1370                 1375 


<210> 289
<211> 1382
<212> PRT
<213> Lactobacillus mucosae


<220>
<223> Lactobacillus mucosae LM1

<400> 289
Met Asp Ile Gly Thr Asn Ser Ile Gly Trp Thr Ala Ile Asp Asp His 
1               5                   10                  15      


Phe Ser Leu Leu Arg Val Lys Gly Lys Asn Ala Ile Gly Val Arg Thr 
            20                  25                  30          


Phe Lys Glu Gly Glu Thr Ala Ala Asp Arg Arg Gly Phe Arg Thr Ala 
        35                  40                  45              


Arg Arg Arg Leu Ser Arg Arg Arg Trp Arg Leu Gln Phe Leu Asp Glu 
    50                  55                  60                  


Phe Phe Ala Pro Tyr Leu Ala Glu Val Asp Pro Asn Phe Leu Ala Arg 
65                  70                  75                  80  


Leu Lys Gln Ser Asp Ile Ser Ala Lys Asp Pro Ala Lys Asn Gln Glu 
                85                  90                  95      


Tyr Met Gly Lys Leu Leu Phe Pro Asp Gln Glu Ala Ala Ser Asp Gly 
            100                 105                 110         


Asn Gly Tyr Pro Thr Leu Ile Gln Met Arg Lys Ala Met Pro Ala Glu 
        115                 120                 125             


Lys Ala Ala Asp Phe Pro Val Phe Asn Ile Tyr Gln Leu Arg Tyr Ala 
    130                 135                 140                 


Leu Met Asn Glu Lys Arg Lys Phe Asp Leu Arg Glu Ile Tyr Leu Ala 
145                 150                 155                 160 


Val His His Ile Val Lys Tyr Arg Gly Asn Phe Leu Asn Asn Thr Ser 
                165                 170                 175     


Val Asp Lys Phe Lys Ala Asp Gln Ile Asp Phe Asn Lys Ser Phe Glu 
            180                 185                 190         


Thr Leu Asn Asp Leu Phe Arg Gln Val Gln Pro Ile Ala Pro Phe Gln 
        195                 200                 205             


Ile Asp Leu Thr Lys Val Asp Glu Leu Gly Lys Leu Leu Leu Asp Thr 
    210                 215                 220                 


Lys Gln Lys Lys Leu Asp Arg Gln Lys Ala Val Ala Lys Leu Leu Pro 
225                 230                 235                 240 


Leu Ile Glu Asp Gly Thr Asp Lys Glu Ile Val Lys Ala His Gln Gln 
                245                 250                 255     


Thr Ala Arg Glu Ile Ser Lys Leu Ile Leu Gly Tyr Lys Ala Lys Val 
            260                 265                 270         


Gly Leu Ile Leu Gln Asn Asn Leu Asp Gln Thr Leu Asp Met Ser Thr 
        275                 280                 285             


Glu Asn Ser Asp Asp Gln Leu Met Gln Ile Ala Glu Glu Leu Asp Asp 
    290                 295                 300                 


Tyr Gln Met Glu Leu Ile Asn Gln Leu Ser Leu Leu Tyr Ser Gln Ile 
305                 310                 315                 320 


Met Leu Asn Glu Ile Val Pro Asn Gly Glu Thr Val Ser Ala Ser Met 
                325                 330                 335     


Leu Asn Arg Tyr Tyr Lys His Arg Cys Gln Leu Lys Glu Leu Lys Asp 
            340                 345                 350         


Tyr Gly Ala Ala Gln Asp Lys Lys Thr Arg Glu Gln Leu Asp His Leu 
        355                 360                 365             


Tyr Ala Glu Tyr Ile Gly Gln Ile Pro Lys Asp Ser Lys Phe Asp Phe 
    370                 375                 380                 


Thr Lys Asp Leu Lys Lys Leu Met Asp Lys Ser Asp Leu Gly Gln Lys 
385                 390                 395                 400 


Ile Lys Asp Glu Ile Glu Ala Gly Asp Tyr Leu Pro Lys Gln Arg Thr 
                405                 410                 415     


Ser Ala Asn Gly Val Ile Pro His Gln Met His Gln Gln Glu Leu Asp 
            420                 425                 430         


Gln Ile Ile Glu Asn Gln Lys Glu Tyr Tyr Pro Trp Leu Ala Glu Pro 
        435                 440                 445             


Asn Pro Val Glu Lys Asn Ile Lys Asn Ala Lys Tyr Lys Leu Asp Gln 
    450                 455                 460                 


Leu Val Ser Phe Arg Val Pro Tyr Tyr Val Gly Pro Met Ile Thr Leu 
465                 470                 475                 480 


Ala Asp Gln Gln Lys Thr Ser Lys Ala Ser Phe Ala Trp Ala Val Arg 
                485                 490                 495     


Lys Lys Ala Gly Lys Ile Thr Pro Trp Asn Phe Tyr Asp Met Ile Asp 
            500                 505                 510         


Arg Glu Lys Ser Ala Asn Asn Phe Ile Lys Arg Met Thr Asn Lys Asp 
        515                 520                 525             


Thr Tyr Leu Leu Ser Glu Asp Val Leu Pro Ala Ser Ser Leu Leu Tyr 
    530                 535                 540                 


Gln Lys Phe Thr Val Leu Asn Glu Leu Asn Asn Ile Arg Val Asn Gly 
545                 550                 555                 560 


Arg Lys Leu Gln Pro Ala Leu Lys Gln Ala Ile Tyr Thr Asp Leu Phe 
                565                 570                 575     


Gln Lys Arg Lys Thr Val Asn Leu Lys Thr Leu Thr Asn Phe Leu Ala 
            580                 585                 590         


Ile His Glu Pro Thr Leu Thr Lys Pro Lys Ile Glu Gly Leu Ser Asn 
        595                 600                 605             


Gly Arg Ser Phe Asn Ser Ser Leu Gly Thr Tyr Ile Asp Met Ser Lys 
    610                 615                 620                 


Ile Leu Gly Asp Ser Leu Asp Asp Leu Asn Tyr Arg Asp Asp Ile Glu 
625                 630                 635                 640 


Lys Ile Ile Glu Trp Ser Thr Val Phe Glu Asp Ser Glu Ile Tyr Gly 
                645                 650                 655     


Val Lys Leu Gln Glu Ile Gln Trp Leu Thr Asn Glu Gln Arg Glu Lys 
            660                 665                 670         


Leu Val Arg Lys Arg Tyr Gln Gly Trp Gly Arg Leu Ser Lys Lys Leu 
        675                 680                 685             


Leu Thr Gly Ile Thr Asp Glu Asn Gly Gln Arg Ile Ile Asp Leu Met 
    690                 695                 700                 


Trp Asp Thr Ser Lys Asn Phe Met Gln Ile Val His Gln Pro Val Phe 
705                 710                 715                 720 


Glu Glu Gln Ile Ala Glu Leu Asn Gln Gln Leu Leu Gln Asp Ala Asp 
                725                 730                 735     


Lys Ala Pro Leu Glu Val Val Asp Asp Ile Leu Ala Asp Ala Tyr Thr 
            740                 745                 750         


Ser Pro Gln Asn Lys Lys Ala Ile Arg Gln Val Val Lys Val Val Ala 
        755                 760                 765             


Asp Val Val Lys Ala Val Gly Asn Ala Pro Ala Ser Ile Ser Ile Glu 
    770                 775                 780                 


Phe Ala Arg Asn Glu Asp Arg Asn Lys Glu Leu Lys Asn Ser Arg Arg 
785                 790                 795                 800 


His Ser Ile Glu Lys Leu Tyr His Glu Thr Ala Glu Lys Leu Val Lys 
                805                 810                 815     


Gln Thr Asn Leu Leu Glu Glu Leu Gly Asn Val Lys Asp Leu Asn Asp 
            820                 825                 830         


Arg Tyr Tyr Leu Tyr Phe Thr Gln Ala Gly Arg Asp Met Tyr Asp Gly 
        835                 840                 845             


Thr Pro Ile Asn Ile Asp Glu Ile Ser Thr His Tyr Glu Ile Asp His 
    850                 855                 860                 


Ile Leu Pro Gln Ser Phe Leu Lys Asp Asn Ser Leu Asp Asn Arg Val 
865                 870                 875                 880 


Leu Val Lys Lys Ser Glu Asn Ala Ala Lys Ser Asp Arg Val Pro Ala 
                885                 890                 895     


Lys Leu Tyr Gly Ala Lys Met Arg Ala Phe Trp Lys Gln Leu Lys Glu 
            900                 905                 910         


Ser Gln Leu Ile Ser Asn Arg Lys Tyr Leu Asn Leu Thr Thr Asp Pro 
        915                 920                 925             


Glu Gln Val Asp Lys Tyr Gln Met Gln Gly Phe Val His Arg Gln Leu 
    930                 935                 940                 


Val Glu Thr Arg Gln Ile Ile Lys Leu Ala Ala Asn Ile Phe Gly Ser 
945                 950                 955                 960 


Leu Tyr Pro Asp Ser Ala Val Ile Glu Thr Arg Ala Glu Leu Thr Lys 
                965                 970                 975     


Gln Leu Arg Glu Lys Phe Ser Leu Tyr Lys Val Arg Asp Val Asn Asp 
            980                 985                 990         


Tyr His His Ala Val Asp Ala Tyr  Leu Thr Ala Phe Ala  Gly His Tyr 
        995                 1000                 1005             


Leu Tyr  Gln Arg Tyr Pro Lys  Leu Arg Pro Met Phe  Val Tyr Gly 
    1010                 1015                 1020             


Asp Tyr  Ala Lys Ile Tyr Ala  Asp Asp Leu Lys Arg  Leu Arg Ser 
    1025                 1030                 1035             


Val Asn  Leu Phe His Asp Leu  Glu Lys Asp Gln Tyr  Asn Ser Gly 
    1040                 1045                 1050             


Thr Ala  Val Asn Pro Glu Thr  Lys Glu Lys Ile Val  Asp Val Asp 
    1055                 1060                 1065             


Trp Leu  Ser Asp Tyr Val Ser  Lys Ile Gln His Phe  Lys Tyr Met 
    1070                 1075                 1080             


Leu Ile  Ser Lys Ala Val Tyr  Thr Gln His Gly Gln  Leu Tyr Gly 
    1085                 1090                 1095             


Ala Thr  Ile Leu Pro Val Ala  Gln Val Asp Lys Ile  Ser Ala Pro 
    1100                 1105                 1110             


Ile Gly  Ile Lys Asp Asp Lys  Pro Val Asp Ile Tyr  Gly Ala Tyr 
    1115                 1120                 1125             


Thr Asn  Glu Val Ala Ala Tyr  Met Ala Ile Val Arg  Val Asn Gly 
    1130                 1135                 1140             


Lys Lys  Pro Lys Tyr Lys Val  Val Ser Val Pro Val  Arg Met Leu 
    1145                 1150                 1155             


Gln Arg  Leu Lys Met Ala Glu  Gln Lys Gly His Asp  Gln Tyr Met 
    1160                 1165                 1170             


Gln Thr  Leu His Asp Val Leu  Leu Arg Asn Phe Thr  Ser Leu Lys 
    1175                 1180                 1185             


Lys Asn  Arg Lys Thr Gly Leu  Lys Glu Ala Val Val  Lys Asp Phe 
    1190                 1195                 1200             


Asp Val  Leu Val Pro Cys Val  Arg Tyr Asn Gln Leu  Val Ile Asp 
    1205                 1210                 1215             


Gly Asp  Thr Lys Phe Thr Leu  Gly Ser Ala Thr Tyr  Gln His Asn 
    1220                 1225                 1230             


Ala Lys  Gln Leu Val Leu Cys  Asn His Ser Leu Glu  Thr Leu Ala 
    1235                 1240                 1245             


Asn Asn  Phe Glu Tyr Val Arg  Lys His Pro Asp Glu  Ala Asp Glu 
    1250                 1255                 1260             


Arg Met  Ile Met Leu Tyr Asp  Asp Ile Leu Asp Gln  Val Asn His 
    1265                 1270                 1275             


Tyr Phe  Thr Leu Tyr Asp Lys  Asn Lys Phe Arg Glu  Lys Leu Asn 
    1280                 1285                 1290             


Ala Gly  Arg Asp Lys Tyr Leu  Lys Leu Pro Thr Phe  Ser Gln Phe 
    1295                 1300                 1305             


Glu Asn  Asn Lys Lys Thr Ala  Ile Gly Lys Ser Glu  Ala Ile Ile 
    1310                 1315                 1320             


Asn Ile  Leu Arg Gly Leu His  Ala Asn Ala Ala Ile  Thr Asn Leu 
    1325                 1330                 1335             


Lys Cys  Leu Gly Val Ser Thr  Pro Phe Gly Gln Leu  Gln Ser Pro 
    1340                 1345                 1350             


Ser Gly  Ile Glu Leu Ser Glu  Asn Ala Lys Leu Val  Tyr Gln Ser 
    1355                 1360                 1365             


Pro Thr  Gly Leu Phe Ser Arg  Glu Val Leu Leu Lys  Asp Leu 
    1370                 1375                 1380         


<210> 290
<211> 1362
<212> PRT
<213> Lactobacillus paracasei


<220>
<223> Lactobacillus paracasei subsp. paracasei 8700:2

<400> 290
Met Thr Lys Leu Gly Lys Pro Tyr Gly Ile Gly Val Asp Ile Gly Ser 
1               5                   10                  15      


Asn Ser Ile Gly Phe Ala Ala Val Asp Glu Asn Ser His Leu Ile Arg 
            20                  25                  30          


Leu Lys Gly Lys Thr Val Ile Gly Ala Arg Leu Phe Glu Glu Gly Lys 
        35                  40                  45              


Ala Ala Ala Lys Arg Arg Ala Gly Arg Thr Thr Arg Arg Arg Leu Ser 
    50                  55                  60                  


Arg Asn Arg Trp Arg Leu Ser Phe Leu Arg Asp Phe Phe Glu Ser His 
65                  70                  75                  80  


Ile Thr Pro Thr Asp Pro Asn Phe Phe Met Arg Gln Lys Tyr Ser Glu 
                85                  90                  95      


Ile Ser Pro Lys Asp Lys Ala Arg Tyr Lys Tyr Glu Lys Arg Leu Phe 
            100                 105                 110         


Asn Asp Arg Thr Asp Ala Glu Phe Tyr Gln Gln Tyr Ser Thr Met Tyr 
        115                 120                 125             


His Leu Arg Asn Arg Leu Met Thr Asp Pro Ser Arg Ala Asp Val Arg 
    130                 135                 140                 


Glu Ile Tyr Phe Ala Ile His His Ile Leu Lys Ser Arg Gly His Phe 
145                 150                 155                 160 


Leu Thr Pro Gly Asp Ala Lys Asp Phe Asn Thr Asn Asp Val Ala Leu 
                165                 170                 175     


Asp Glu Ile Phe Pro Ala Leu Gln Asp Ala Tyr Ala Gln Val Tyr Pro 
            180                 185                 190         


Asp Leu Gly Ile Thr Phe Asp Glu Asp Lys Ala Asn Glu Phe Lys Thr 
        195                 200                 205             


Ile Leu Leu Asn Glu Ile Ala Thr Ser Ile Asp Thr Gln Arg Ala Leu 
    210                 215                 220                 


Val Lys Leu Leu Leu Ala Glu Glu Asp Asp Lys Asp Ile Leu Lys Gln 
225                 230                 235                 240 


Gln Lys Gln Val Leu Thr Glu Phe Ala Lys Ala Val Val Gly Leu Lys 
                245                 250                 255     


Thr Lys Leu Asn Leu Ala Leu Gly Thr Glu Val Asp Ser Ser Glu Ala 
            260                 265                 270         


Thr Ala Trp Asn Phe Ser Leu Gly Gln Leu Asp Asp Lys Trp Ala Gly 
        275                 280                 285             


Ile Glu Ser Ala Met Thr Asp Glu Gly Thr Glu Ile Leu Asp Gln Ile 
    290                 295                 300                 


Arg Asp Leu Tyr Arg Ala Arg Leu Leu Asn Gly Ile Val Pro Thr Gly 
305                 310                 315                 320 


Lys Thr Leu Ser Gln Ala Lys Val Asp Asp Tyr Thr Gln His His Glu 
                325                 330                 335     


Asp Leu Gln Leu Phe Lys Ala Tyr Leu Lys Gln Leu Glu Asp Asp Gly 
            340                 345                 350         


Thr Ala Lys Ala Ile Arg Gln Leu Tyr Asp Arg Tyr Ile Asp Gly Asp 
        355                 360                 365             


Asp Ala Ala Pro Phe Leu Arg Glu Asn Phe Val Lys Ala Leu Thr Lys 
    370                 375                 380                 


Asp Val Thr Ala His Pro Asn Thr Lys Ser Pro Glu Leu Leu Glu Arg 
385                 390                 395                 400 


Leu Ala Gln Pro Asp Phe Met Leu Lys Gln Arg Asn Lys Ala Asn Gly 
                405                 410                 415     


Ala Ile Pro Val Gln Met Gln Gln Arg Glu Leu Asp Gln Ile Ile Lys 
            420                 425                 430         


Asn Gln Ala Val Tyr Tyr Asp Trp Leu Ala Ala Pro Asn Pro Val Glu 
        435                 440                 445             


Lys His Arg Lys Ser Met Pro Tyr Gln Leu Asp Glu Leu Leu Asn Phe 
    450                 455                 460                 


Arg Ile Pro Tyr Tyr Val Gly Pro Leu Val Thr Ala Lys Glu Gln Lys 
465                 470                 475                 480 


Ala Ala Gln Gly Gly Val Phe Ala Trp Met Val Arg Lys Asp Pro Glu 
                485                 490                 495     


Gly Asn Ile Thr Pro Tyr Asn Phe Asp Glu Lys Val Asp Arg Glu Ala 
            500                 505                 510         


Ser Ala Asn Thr Phe Ile Gln Arg Met Lys Thr Thr Asp Thr Tyr Leu 
        515                 520                 525             


Ile Gly Glu Asp Val Leu Pro Lys Gln Ser Leu Leu Tyr Gln Arg Tyr 
    530                 535                 540                 


Glu Val Leu Asn Glu Leu Asn Asn Val Arg Val Asn Asn Glu Lys Leu 
545                 550                 555                 560 


Ser Ile Glu Gln Lys Gln Gln Val Ile Arg Glu Leu Phe Glu Arg His 
                565                 570                 575     


Asn Ser Val Thr Ile Lys Gln Phe Ala Glu Asn Leu Arg Ala His Gly 
            580                 585                 590         


Asp Tyr Ala His Ile Pro Glu Ile Arg Gly Leu Ala Asp Glu Lys Arg 
        595                 600                 605             


Phe Leu Ser Ser Leu Ser Thr Tyr Arg Gln Leu Lys Ser Leu Leu Pro 
    610                 615                 620                 


Glu Ala Ile Asp Asp Pro Ala Lys Gln Ala Asp Ile Glu Asn Ile Ile 
625                 630                 635                 640 


Ala Trp Ser Thr Val Phe Glu Asp Ala Ala Ile Phe Lys Thr Lys Leu 
                645                 650                 655     


Lys Glu Ile Ser Trp Leu Gly Ser Glu Ala Ile Thr Lys Leu Ser Asn 
            660                 665                 670         


Ile Arg Tyr Arg Gly Trp Gly Gln Phe Ser Arg Lys Phe Leu Asn Gly 
        675                 680                 685             


Leu Thr Leu Gly Asn Gly His Thr Ile Ile Gln Glu Leu Leu Leu Ser 
    690                 695                 700                 


Thr Asn Asn Leu Met Gln Ile Leu Thr Asp Glu Thr Leu Gln Lys Lys 
705                 710                 715                 720 


Met Thr Glu Leu Asn Ala Asp Lys Leu Lys Thr Ala Asn Ile Asn Asp 
                725                 730                 735     


Ala Ile Asp Asn Ala Tyr Thr Ser Pro Ser Asn Lys Lys Ala Leu Arg 
            740                 745                 750         


Gln Val Leu Arg Val Val Asp Asp Ile Lys Arg Ala Ala Asp Gly Gln 
        755                 760                 765             


Asp Pro Ser Trp Leu Tyr Val Glu Thr Ala Asp Gly Gly Gly Thr Pro 
    770                 775                 780                 


Gly Lys Arg Thr Arg Ala Arg Gln His Gln Leu Gln Glu Ile Tyr Ala 
785                 790                 795                 800 


Asn Ala Ala His Glu Leu Ile Asp Thr Ala Val Arg Gly Glu Leu Glu 
                805                 810                 815     


Asp Lys Ile Ser Asp Lys Ala Asp Phe Asn Asp Arg Leu Val Leu Tyr 
            820                 825                 830         


Phe Met Gln Gly Gly Arg Asp Ile Tyr Thr Gly Ala Pro Leu Asn Ile 
        835                 840                 845             


Asp Gln Leu Ser Ser Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Leu 
    850                 855                 860                 


Ile Lys Asp Asn Ser Leu Asp Asn Arg Val Leu Val His Ala Ile Ile 
865                 870                 875                 880 


Asn Arg Glu Lys Asn Ala Thr Phe Ala Ser Thr Ile Tyr Ala Gln Lys 
                885                 890                 895     


Met Asn Ala Thr Trp Arg Gln Trp His Glu Ala Gly Leu Ile Ser Gly 
            900                 905                 910         


Arg Lys Leu Arg Asn Leu Gln Met Arg Pro Asp Gln Ile Asp Lys Tyr 
        915                 920                 925             


Ala Ser Gly Phe Val Ala Arg Gln Leu Val Glu Thr Arg Gln Ile Ile 
    930                 935                 940                 


Lys Leu Thr Glu Gln Ile Val Ala Ala Gln Tyr Pro Asp Thr Lys Ile 
945                 950                 955                 960 


Ile Ala Val Lys Ala Gly Leu Ser His Gln Leu Arg Glu Glu Leu Glu 
                965                 970                 975     


Phe Pro Lys Asn Arg Asp Val Asn His Tyr His His Ala Phe Asp Ala 
            980                 985                 990         


Phe Leu Ala Ala Arg Ile Gly Thr  Tyr Leu Leu Lys Arg  Phe Pro Asn 
        995                 1000                 1005             


Leu Gln  Ala Phe Phe Thr Tyr  Gly Lys Phe Thr Lys  Ala Asp Val 
    1010                 1015                 1020             


Lys Lys  Leu Arg Gly Phe Asn  Phe Ile Arg Asp Ile  Thr His Ala 
    1025                 1030                 1035             


Glu Asp  Lys Ile Val Ala Lys  Asp Thr Gly Glu Val  Val Trp Asp 
    1040                 1045                 1050             


Lys Gln  Arg Asp Val Asp Glu  Leu Asp Arg Ile Tyr  Asn Phe Lys 
    1055                 1060                 1065             


Arg Met  Leu Ile Thr His Glu  Val Arg Phe Glu Thr  Ala Asp Leu 
    1070                 1075                 1080             


Phe Lys  Gln Thr Val Tyr Gly  Ala Arg Asp Ser Lys  Glu Ala Gly 
    1085                 1090                 1095             


Gly Ser  Lys Gln Leu Ile Pro  Lys Lys Lys Gly Tyr  Pro Val Asp 
    1100                 1105                 1110             


Ile Tyr  Gly Gly Tyr Phe Arg  Glu Asn Thr Ala Tyr  Leu Ala Val 
    1115                 1120                 1125             


Val Lys  Val Thr Lys Lys Thr  Glu Thr Ile Phe Lys  Val Val Lys 
    1130                 1135                 1140             


Ile Ala  Thr Ser Gln Val Ala  Ala Leu Asn Lys Ala  Arg Ser Arg 
    1145                 1150                 1155             


Ser Thr  Ala Glu Glu Leu Ser  Val Leu Thr Glu Leu  Leu Lys Pro 
    1160                 1165                 1170             


Lys Phe  Ser Lys Val Gly Lys  Asn Gly Lys Ile Thr  Asp Thr Pro 
    1175                 1180                 1185             


Phe Glu  Val Val Leu Pro Arg  Val Pro Arg Glu Gln  Leu Phe Tyr 
    1190                 1195                 1200             


Asn Ala  Lys Tyr Gly Phe Phe  Met Val Asn Ser Asp  Thr Met Phe 
    1205                 1210                 1215             


His Asn  Phe Gln Glu Ile Trp  Val Ser Arg Ser Asp  Gln Lys Ile 
    1220                 1225                 1230             


Leu Gln  Gln Ile Arg Lys Ala  Lys Ile Asp Tyr Pro  Asn Val Asp 
    1235                 1240                 1245             


Gln Asp  Leu Asp Asn Leu Phe  His Asn Leu Ala Asp  Gln Ile Val 
    1250                 1255                 1260             


Lys Tyr  Phe Asp Leu Tyr Ser  Ile Ala Gly Phe Lys  Glu Lys Ile 
    1265                 1270                 1275             


Ser Gln  Ser Gln Asn Thr Phe  Asn Asp Leu Ala Val  Asp Asp Thr 
    1280                 1285                 1290             


Asp Gln  Ser Val Gly Lys Ile  Thr Val Ile Asn Glu  Leu Leu Lys 
    1295                 1300                 1305             


Gly Ala  Gln Ala Asn Gly Met  Thr Gly Ser Leu Lys  Val Leu Lys 
    1310                 1315                 1320             


Ile Ser  Thr Pro Phe Gly Phe  Thr Gln Asp Lys Ser  Gly Val Leu 
    1325                 1330                 1335             


Thr Lys  Asp Ser Ser Ile Ile  Tyr Gln Ser Pro Thr  Gly Leu Phe 
    1340                 1345                 1350             


Glu Arg  Ser Val Arg Leu Thr  Asp Leu 
    1355                 1360         


<210> 291
<211> 1382
<212> PRT
<213> Lactobacillus pentosus


<220>
<223> Lactobacillus pentosus IG1

<400> 291
Met Lys Lys Ile Val Asn Tyr Asn Leu Gly Leu Asp Ile Gly Thr Ser 
1               5                   10                  15      


Ser Ile Gly Tyr Ala Ala Ile Asp Asp Gln Gly Arg Pro Val Arg His 
            20                  25                  30          


Gln Asn Lys Thr Val Met Gly Val Arg Leu Phe Lys Glu Gly Lys Thr 
        35                  40                  45              


Ala Glu Ser Thr Arg Ile Phe Arg Gly Thr Arg Arg Arg Leu Ser His 
    50                  55                  60                  


Arg His Trp Arg Leu Gly Tyr Leu Asp Arg Ile Phe Asp Asn Glu Ile 
65                  70                  75                  80  


Ala Lys Val Asp Glu Asn Phe Leu Pro Arg Leu Lys Ala Ser Lys Arg 
                85                  90                  95      


Ala Arg Ser Asp Glu Lys Arg Ser Phe Arg Gly Ser Leu Leu Phe Pro 
            100                 105                 110         


Glu Thr Gly Asp Asp Ala Tyr Tyr Gln Lys Tyr Pro Thr Ile Tyr His 
        115                 120                 125             


Leu Arg Tyr Ala Leu Ile Thr Gln Lys Lys Gln Phe Asp Ile Arg Leu 
    130                 135                 140                 


Ile Tyr Leu Ala Leu His His Met Ile Lys Tyr Arg Gly Asn Phe Leu 
145                 150                 155                 160 


Asp Thr Thr Pro Val Ser Ala Phe Asn Ile His Asp Ile Asp Leu Thr 
                165                 170                 175     


Asp Gln Phe Ala Ser Leu Asn Asp Cys Tyr Gln Leu Leu Asp Met Asp 
            180                 185                 190         


Phe Glu Phe Gln Phe Asp Leu Asn Asn Ile Glu Gln Val Gln Lys Leu 
        195                 200                 205             


Leu Leu Asp Glu Thr Leu Ser Lys Thr Lys Arg Gln Ala Ala Val Ser 
    210                 215                 220                 


Lys Val Leu Val Met Ser Thr Gly Asn Lys Ala Phe Asp Asp Gln Gln 
225                 230                 235                 240 


Asn Gly Ile Ala Ser Glu Phe Ile Lys Ala Leu Leu Gly Gly Pro Phe 
                245                 250                 255     


Asp Leu Ser Lys Ile Leu Asn Leu Ser Val Ala Asp Val Lys Ser Trp 
            260                 265                 270         


Lys Leu His Met Thr Asp Lys Asp Val Asp Asp Thr Leu Asn Ser Leu 
        275                 280                 285             


Val Glu Glu Leu Asp Glu Asn His Lys Gln Ile Val Asn Leu Leu Gln 
    290                 295                 300                 


Met Ile Tyr Ser Gln Val Met Met Leu Gly Leu Leu Asn Gly Gln Gln 
305                 310                 315                 320 


Ser Ile Ser Ala Ser Met Ile Glu Arg Tyr Asp Asp His Ala Lys His 
                325                 330                 335     


Trp Ala Ala Leu Lys Lys Leu Leu Pro Ala Leu Gly Glu Gln Glu Gln 
            340                 345                 350         


Ser Thr Ile Ile His Ala Tyr Thr Ala Tyr Thr Gly His Ser Arg Thr 
        355                 360                 365             


Lys Gln Leu Ser Arg Ala Glu Phe Tyr Thr Lys Val Asn Ser Ile Leu 
    370                 375                 380                 


Lys Lys His Glu Asn Ile Ala Glu Ala Thr Gly Leu Ile Glu Leu Ile 
385                 390                 395                 400 


Asp Arg Asn Glu Phe Met Pro Lys Gln Arg Asp Ala Val Asn Gly Val 
                405                 410                 415     


Ile Pro His Gln Leu His Gln Arg Glu Leu Gln Leu Ile Ile Gln Asn 
            420                 425                 430         


Gln Gln Lys Tyr Tyr Pro Phe Leu Ala Ala Lys Ala Tyr Pro Asp Ala 
        435                 440                 445             


Asp Glu Thr Met Ile Glu Gln Leu Leu Ser Phe Arg Val Pro Tyr Tyr 
    450                 455                 460                 


Ala Gly Pro Leu Val Asp Arg Asp Phe Ile Asn Glu Ser Ser Asp Gln 
465                 470                 475                 480 


Glu Gln Ala Met Gln Asn Thr Lys Phe Ser Trp Leu Lys Arg Arg Glu 
                485                 490                 495     


Ala Gly Glu Ile Thr Pro Trp Asn Phe Glu Gln Lys Val Asp Val Gln 
            500                 505                 510         


Glu Thr Ala Asn Arg Phe Ile Lys Arg Leu Thr Thr Lys Asp Thr Tyr 
        515                 520                 525             


Leu Met Thr Glu Asp Val Leu Pro Lys Glu Ser Leu Ile Tyr Gln Arg 
    530                 535                 540                 


Phe Glu Val Leu Asn Glu Leu Asn Ala Ile Arg Ile Asn Asp Arg Arg 
545                 550                 555                 560 


Leu Thr Ala Glu Asn Lys Gln Leu Ala Phe Gln Gln Leu Phe Met Ala 
                565                 570                 575     


Gly Asn Thr Lys Asn Val Ser Ile Lys Lys Phe Arg Asn Phe Val Phe 
            580                 585                 590         


Asp Ser Leu Lys Phe Pro Glu Lys Val Lys Ile Thr Gly Phe Ala Gly 
        595                 600                 605             


Gln His Asn Phe Leu Ala Lys Leu Ser Thr Tyr His Asp Phe Lys Lys 
    610                 615                 620                 


Ile Phe Gly Glu Arg Val Asp His Thr Asp Leu Gln Pro Asp Phe Glu 
625                 630                 635                 640 


Arg Ile Val Glu Trp Cys Thr Ile Phe Glu Asp Arg His Ile Tyr Arg 
                645                 650                 655     


Glu Lys Leu Lys Glu Ile Gln Trp Leu Ser Gln Ser Glu Ile Asp Gln 
            660                 665                 670         


Leu Val Leu Ile Arg Asn His Gly Trp Gly Arg Leu Ser Lys Arg Leu 
        675                 680                 685             


Leu Thr Gly Ile Arg Asp Ser Asp Gly Arg Thr Val Met Asp Gln Leu 
    690                 695                 700                 


Trp Phe Gly Thr Asp Asn Phe Met Arg Ile Ile Ser Gln Ser Asp Phe 
705                 710                 715                 720 


Ala Ala Ala Ile Ala Asn Glu Asn Arg Thr Gln Leu Asn Gln His Gly 
                725                 730                 735     


Leu Glu Asp Val Leu Asp Ser Ala Phe Met Ser Pro Gln Asn Lys Lys 
            740                 745                 750         


Ala Ile Arg Gln Val Leu Lys Val Val Asp Asp Ile Glu Gln Thr Leu 
        755                 760                 765             


Gly Cys Pro Pro Lys Lys Val Met Ile Glu Phe Thr Arg Ser Pro Asp 
    770                 775                 780                 


Lys Lys Lys Gln Arg Thr Val Thr Arg Leu Glu Lys Val Gln Gln Ala 
785                 790                 795                 800 


Tyr Lys Ala Val Ala Asp Gln Leu Ala Gly Gln Ser Ile Val Ser Glu 
                805                 810                 815     


Leu Asp Gln Tyr Ala Asn Thr His Ser Lys Leu Ser Asp Thr Tyr Tyr 
            820                 825                 830         


Leu Tyr Phe Met Gln Leu Gly Arg Asp Leu Tyr Ser Gly Lys Pro Ile 
        835                 840                 845             


Asp Ile Asp Ser Pro Met Leu Asp Asp Asp His Ile Leu Pro Arg Ala 
    850                 855                 860                 


Phe Met Lys Asp Asn Ser Leu Asp Asn Arg Ala Leu Thr Glu Lys Pro 
865                 870                 875                 880 


Ile Asn Asn Thr Lys Ala Ala Lys Phe Pro Ser Lys Val Phe Gly Gln 
                885                 890                 895     


Gln Lys Glu Val Thr Asp Phe Trp Lys Leu Leu Arg Arg Cys Gly Leu 
            900                 905                 910         


Met Ser Asn Ile Lys Glu Lys His Leu Tyr Leu Asp Pro Asp Asn Val 
        915                 920                 925             


Asp Lys Trp Thr Arg Arg Gly Phe Ile His Arg Gln Leu Val Glu Thr 
    930                 935                 940                 


Ser Gln Val Ile Lys Ile Val Ala Asn Ile Leu Asn Asp Arg Tyr Gln 
945                 950                 955                 960 


Gln Ser Gln Thr Glu Val Leu Glu Val Pro Ala Arg Leu Gly Thr Glu 
                965                 970                 975     


Leu Arg Glu Cys Phe Gly Trp Tyr Lys Val Arg Glu Val Asn Asp Tyr 
            980                 985                 990         


His His Val Phe Asp Ala Tyr Leu  Ala Ala Phe Ile Gly  Asn Tyr Leu 
        995                 1000                 1005             


Tyr Arg  Arg Tyr Pro Lys Leu  Gln Pro Tyr Phe Val  Tyr Gly Asn 
    1010                 1015                 1020             


Phe Ala  Glu Leu Asn Lys Ala  Gln Leu Lys Asn Ile  Lys Ser Phe 
    1025                 1030                 1035             


Asn Phe  Leu Tyr Asn Ile Thr  Asp Asn Lys Arg Val  Val Lys Asp 
    1040                 1045                 1050             


Ile Glu  Thr Gly Gln Thr Leu  Trp Asp Asp Gln Ile  Arg Gln Gln 
    1055                 1060                 1065             


Ile Gln  His Ile Tyr Glu Tyr  Lys Tyr Met Leu Thr  Ser His Glu 
    1070                 1075                 1080             


Ala Phe  Thr Gln His Lys Glu  Leu Tyr Gly Gln Thr  Ile Tyr Pro 
    1085                 1090                 1095             


Arg Arg  Glu Phe Lys Pro Gly  Thr Leu Lys Ala Ile  Lys Gln Asp 
    1100                 1105                 1110             


Gln Pro  Gln Glu Leu Tyr Gly  Gly Tyr Lys Asn Leu  Thr Ala Ala 
    1115                 1120                 1125             


Tyr Met  Cys Ile Val Lys Ile  Gln Ala Arg Lys Arg  Arg Ala Ala 
    1130                 1135                 1140             


Glu Tyr  Arg Val Val Arg Val  Ala Thr Glu Ser Leu  Ser Ala Leu 
    1145                 1150                 1155             


Gln Gln  Ala Lys Arg Leu Gly  Val Gln Ala Tyr Glu  Arg Cys Leu 
    1160                 1165                 1170             


Arg Gln  Glu Leu Val Arg Asn  Asn Glu Ile Leu Arg  Thr Asn Ala 
    1175                 1180                 1185             


Asp Pro  Asn Ser Ala Pro Arg  Glu Phe Glu Val Leu  Leu Asp Arg 
    1190                 1195                 1200             


Val Leu  Cys His Gln Met Ile  Ile Ser Asp Gly Gln  Lys Tyr Leu 
    1205                 1210                 1215             


Leu Gly  Ser His Ala Tyr Lys  Ile Asn Cys Met Gln  Leu Val Leu 
    1220                 1225                 1230             


Ser Asn  Asn Ser Met Lys Ile  Leu Ser Thr Ser Ile  Val Lys Leu 
    1235                 1240                 1245             


Lys Gln  Met Thr Asn Glu Pro  Leu Val Gln Val Tyr  Arg Glu Ile 
    1250                 1255                 1260             


Leu Asp  Val Val Asn Lys Tyr  Phe Thr Leu Tyr Asp  Val Asn Ser 
    1265                 1270                 1275             


Phe Arg  Glu Asn Leu Asn Gln  Phe Phe Asp Lys Phe  Arg Thr Leu 
    1280                 1285                 1290             


Pro Ile  Thr Asn Glu Tyr Glu  Ser Ser Lys Ser Gly  Lys Lys Leu 
    1295                 1300                 1305             


Ile His  Arg Gly Gln Leu Glu  Thr Leu Thr Leu Ile  Leu Arg Gly 
    1310                 1315                 1320             


Leu His  Ala Asn Ser Asp Lys  Val Gln Tyr Gly Asp  Gln Ser Thr 
    1325                 1330                 1335             


Leu Leu  Gly Gly Phe Gln Thr  Lys Asp Gly Ile Lys  Leu Ser Lys 
    1340                 1345                 1350             


Asp Ser  Val Ile Gln Tyr Thr  Ser Pro Ala Gly Leu  Asn Val Arg 
    1355                 1360                 1365             


Thr Val  Lys Leu Arg Asp Leu  Glu Gln Lys Glu Ala  Gln Lys 
    1370                 1375                 1380         


<210> 292
<211> 1361
<212> PRT
<213> Lactobacillus pentosus


<220>
<223> Lactobacillus pentosus KCA1

<400> 292
Met Asn Glu Pro Tyr Gly Val Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Thr Val Val Asp Met Asn Gly Arg Val Arg Lys Val Lys Gly 
            20                  25                  30          


Lys Thr Ala Leu Gly Ala Arg Leu Phe Lys Glu Gly Ala Thr Ala Glu 
        35                  40                  45              


Asp Arg Arg Gly Phe Arg Thr Thr Arg Arg Arg Leu Lys Arg Val Lys 
    50                  55                  60                  


Trp Arg Leu Arg Leu Leu Arg Glu Phe Phe Asp Gln Pro Ile Ser Lys 
65                  70                  75                  80  


Ile Asp Pro Asn Phe Phe Ala Arg Arg Lys Tyr Ser Asp Ile Ser Pro 
                85                  90                  95      


Arg Asp Pro Asn Tyr Asn Gly Leu Ala Lys Thr Leu Phe Asn Asp Arg 
            100                 105                 110         


Thr Asp Lys Glu Phe Tyr Asp Asp Tyr Ala Thr Ile Tyr His Leu Arg 
        115                 120                 125             


Asp Lys Leu Met Thr Ser Asn Arg Lys Phe Asp Ile Arg Glu Ile Tyr 
    130                 135                 140                 


Leu Ala Ile His His Ile Val Lys Tyr Arg Gly Asn Phe Leu Arg Thr 
145                 150                 155                 160 


Gly Pro Ala Ser Gln Tyr Gly Ser Ala Ser Leu His Leu Ala Thr Ser 
                165                 170                 175     


Phe Gln Lys Leu Asn Asp Leu Phe Ala Gln Ser Glu Glu Thr Leu Asn 
            180                 185                 190         


Leu Lys Leu Val Thr Asp Glu Ala Leu Leu Gln Gln Ile Gln Gln Ile 
        195                 200                 205             


Leu Val Arg Thr Asp Leu Ser Arg Ser Glu Gln Gln Arg Gln Ile Trp 
    210                 215                 220                 


Pro Leu Met Ala Val Leu Thr Gly Ala Ser Ala Ala Glu Lys Lys Arg 
225                 230                 235                 240 


Gln Lys Asn Val Val Val Glu Leu Ser Lys Ala Leu Val Gly Leu Lys 
                245                 250                 255     


Ala Lys Met Asn Val Val Thr Leu Thr Glu Val Asp Ala Ala Val Val 
            260                 265                 270         


Lys Asp Trp Thr Phe Thr Met Glu Glu Ser Gln Asp Lys Leu Pro Glu 
        275                 280                 285             


Ile Glu Glu Gln Leu Ser Glu Val Gly Gln Gln Ile Met Asp Glu Val 
    290                 295                 300                 


Ile Gln Leu Tyr Ala Ser Val Asn Leu Ala Gln Leu Ile Pro Ala Gly 
305                 310                 315                 320 


Lys Arg Phe Ser Gln His Met Val Glu Lys Tyr Lys His His Glu Lys 
                325                 330                 335     


Asn Leu Glu Leu Leu Lys Ala Tyr Ile His Ser Gln Ser Asp Ser Lys 
            340                 345                 350         


Arg Gly Arg Glu Ile Arg Ala Thr Tyr Asp Arg Tyr Ile Asp Gly Val 
        355                 360                 365             


Asp Ser Lys Pro Val Thr Gln Glu Met Phe Tyr Lys Asp Leu Met Lys 
    370                 375                 380                 


Tyr Val Glu Ala Asp Ala Thr Ser Asn His Leu Ala Ala Glu Ile Lys 
385                 390                 395                 400 


Asp Glu Ile Asp Ser Glu Gln Phe Met Pro Lys Leu Arg Thr Lys Gln 
                405                 410                 415     


Asn Gly Ser Ile Pro Tyr Gln Val Gln Gln Tyr Glu Leu Asp Gln Ile 
            420                 425                 430         


Ile Ser His Gln Lys Lys Tyr Tyr Pro Trp Leu Gly Glu Glu Asn Pro 
        435                 440                 445             


Val Ala Glu Arg Arg Gly Lys Phe Pro Tyr Lys Leu Asp Glu Leu Val 
    450                 455                 460                 


Gly Phe Arg Val Pro Tyr Tyr Val Gly Pro Leu Ile Thr Lys Glu Asp 
465                 470                 475                 480 


Gln Gln Ala Thr Ser Gly Ala Gly Phe Ala Trp Met Val Arg Lys Ala 
                485                 490                 495     


Asp Gly Pro Ile Thr Pro Trp Asn Phe Asp Gln Lys Val Asp Arg Ile 
            500                 505                 510         


Ala Ser Ala Thr Ala Phe Ile Gln Arg Met Gln Thr Thr Asp Thr Tyr 
        515                 520                 525             


Leu Ile Gly Glu Asp Val Leu Pro Ala Arg Ser Leu Ile Tyr Gln Arg 
    530                 535                 540                 


Phe Met Val Leu Asn Glu Leu Asn Asn Met Arg Val Glu Asp Arg Lys 
545                 550                 555                 560 


Leu Ala Pro Gln Gln Lys Gln Arg Leu Tyr Asn Gln Val Phe Lys Gln 
                565                 570                 575     


His Gln His Val Ser Val Lys Asn Ile Gln Gln Asn Leu Met Asp Ala 
            580                 585                 590         


Gly Glu Tyr Arg Lys Thr Pro Gln Ile Thr Gly Leu Ala Asp Pro Lys 
        595                 600                 605             


Gly Phe Asn Ser Ser Leu Ser Thr Tyr His Asp Phe Lys Lys Ile Leu 
    610                 615                 620                 


Leu Glu Ala Ile Ala Asp Glu His Lys Arg Ala Asp Ile Glu Lys Ile 
625                 630                 635                 640 


Ile Leu Trp Ser Thr Thr Phe Glu Asp Ser Ala Ile Phe Lys Gln Lys 
                645                 650                 655     


Leu Glu Glu Val Ala Trp Leu Thr Asp Ala Gln Arg Lys Gln Leu Ser 
            660                 665                 670         


Gly Leu Arg Tyr Arg Gly Trp Gly Gln Leu Ser His Lys Leu Leu Thr 
        675                 680                 685             


Ala Phe Lys Asp Asp Lys Gly Arg Ser Ile Met Asp Gly Leu Trp Glu 
    690                 695                 700                 


Thr Ser Asp Asn Phe Met Gln Leu Arg Lys Gln Pro Ala Ile Glu Thr 
705                 710                 715                 720 


Gln Ile Lys Glu Ala Asn Gln Ala Asn Leu Thr Asp Ala Asp Ile Gln 
                725                 730                 735     


Asp Thr Ile Asn Glu Leu Tyr Thr Ser Pro Gln Asn Lys Lys Ala Ile 
            740                 745                 750         


Arg Glu Val Met Leu Val Leu Asp Asp Ile Lys Asn Ala Met His Gly 
        755                 760                 765             


Gln Thr Pro Ser Trp Ile Phe Val Glu Ala Ala Arg Gly Gly Gly Val 
    770                 775                 780                 


Ala Gly Arg Arg Thr Gln Ser Arg Ser Ser Gln Ile Val Glu Ala Tyr 
785                 790                 795                 800 


Lys Gly Thr Ala Lys Glu Ile Val Ser Glu Lys Val Gln His Glu Leu 
                805                 810                 815     


Asn Glu Lys Ile Lys Ala Lys Ala Asp Phe Asn Thr Arg Leu Val Leu 
            820                 825                 830         


Tyr Phe Leu Gln Asn Gly Arg Asp Leu Tyr Thr Asn Glu Ala Ile Asn 
        835                 840                 845             


Ile Asp Arg Leu Ser Glu Tyr Asp Ile Asp His Ile Leu Pro Gln Ser 
    850                 855                 860                 


Leu Val Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser Ala Arg 
865                 870                 875                 880 


Ile Asn Arg Glu Lys Asn Asp Thr Phe Ala Ser Glu Lys Phe Gly Arg 
                885                 890                 895     


Lys Met Gly Ala Gln Trp Arg Glu Leu His Arg Asn Gly Leu Met Thr 
            900                 905                 910         


Gln Arg Lys Leu Lys His Leu Leu Met Arg Pro Asp Glu Ile Ser Lys 
        915                 920                 925             


His Ala Thr Asp Phe Ile Asn Arg Gln Leu Val Glu Thr Arg Gln Val 
    930                 935                 940                 


Ile Lys Leu Val Glu Glu Leu Ile Ser Ser Glu Tyr Pro Ala Ala Ser 
945                 950                 955                 960 


Ile Val Ala Val Lys Ala Asn Leu Thr His Gln Phe Arg Gln Thr Phe 
                965                 970                 975     


Asn Phe Pro Lys Leu Arg Glu Val Asn Asp Tyr His His Ala Phe Asp 
            980                 985                 990         


Ala Ser Leu Thr Ala Phe Ile Gly  Met Tyr Leu Leu Lys  Gln Tyr Pro 
        995                 1000                 1005             


Lys Leu  Glu Arg Phe Phe Val  Tyr Gly Lys Phe Ala  Lys Gln Pro 
    1010                 1015                 1020             


Ile Asn  Leu Thr Arg Phe Asn  Ile Ile Arg Lys Leu  Ala Val Ala 
    1025                 1030                 1035             


Glu Lys  Pro Ile Ala Asn Ile  Glu Thr Gly Glu Ile  Leu Trp Asp 
    1040                 1045                 1050             


Lys Thr  Ala Asp Ile Lys Tyr  Phe Glu Lys Leu Tyr  Asn Tyr Lys 
    1055                 1060                 1065             


Arg Leu  Leu Val Thr His Glu  Val Arg Glu Asn Tyr  Gly Ala Met 
    1070                 1075                 1080             


Phe Lys  Gln Thr Leu Phe Lys  Ala Ser Tyr Asn Lys  Ser Lys Thr 
    1085                 1090                 1095             


Leu Val  Pro Lys Lys Asn His  Met Glu Thr Ser Val  Tyr Gly Gly 
    1100                 1105                 1110             


Tyr Ser  Asn Gln Glu Thr Ala  Tyr Leu Ala Ile Val  Arg Ile Pro 
    1115                 1120                 1125             


Phe Lys  Ser Gly Phe Lys Phe  Ile Val Val Gly Ile  Pro Thr Arg 
    1130                 1135                 1140             


Met Val  Ala Lys Ile Lys His  Tyr Gln Ser Leu Gly  Ala Thr Leu 
    1145                 1150                 1155             


Asn Gln  Ala Thr His Lys Val  Ile Glu Pro Lys Phe  Thr Lys Ile 
    1160                 1165                 1170             


Ser Arg  Lys Thr Lys Gln Thr  Val Ile Ser Asp Tyr  Glu Val Val 
    1175                 1180                 1185             


Leu Pro  Lys Val Tyr Leu Asp  Gln Val Val Arg Asp  Gln Val Lys 
    1190                 1195                 1200             


Gly Gln  Met Tyr Arg Phe Ser  Leu Gly Ser Asp Lys  Glu Tyr His 
    1205                 1210                 1215             


Asn Val  Gln Glu Leu Tyr Leu  Pro Leu Ser Ile Gln  Gln Ala Phe 
    1220                 1225                 1230             


Val Gly  His Tyr Asp Glu Ser  Asp Asp Gln Arg Ser  Asn Asp Leu 
    1235                 1240                 1245             


Val Lys  Val Tyr Asp Ala Ala  Leu Lys Gln Leu Gln  Arg Tyr Phe 
    1250                 1255                 1260             


Pro Leu  His Leu Ser Arg Asn  Phe Asp Gln Val Ala  Ser Gln Ala 
    1265                 1270                 1275             


His Gln  Ser Phe Glu Gly Leu  Lys Asn Asn Val Gln  Thr Ser Asp 
    1280                 1285                 1290             


Lys Gln  Leu Gly Lys Lys Glu  Val Leu Asn Ser Leu  Phe Val Gly 
    1295                 1300                 1305             


Leu His  Ala Asn Ala Thr Arg  Ser Asn Leu Ser Val  Leu Gly Met 
    1310                 1315                 1320             


Ser Lys  Asp Phe Gly Arg Ile  Lys Ser Asn Gly Ile  Thr Leu Thr 
    1325                 1330                 1335             


Asp Gln  Ala Glu Ile Ile Tyr  Gln Ser Pro Thr Gly  Leu Phe Glu 
    1340                 1345                 1350             


Arg Lys  Val Ala Leu Lys Asp  Leu 
    1355                 1360     


<210> 293
<211> 1358
<212> PRT
<213> Lactobacillus pentosus


<220>
<223> Lactobacillus pentosus MP-10

<400> 293
Met Asn Glu Pro Tyr Gly Val Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Thr Val Val Asp Met Asn Gly Arg Val Arg Lys Val Lys Gly 
            20                  25                  30          


Lys Thr Ala Leu Gly Ala Arg Leu Phe Lys Glu Gly Ala Thr Ala Glu 
        35                  40                  45              


Asp Arg Arg Gly Phe Arg Thr Thr Arg Arg Arg Leu Lys Arg Val Lys 
    50                  55                  60                  


Trp Arg Leu Arg Leu Leu Arg Glu Phe Phe Asp Gln Pro Ile Ser Lys 
65                  70                  75                  80  


Ile Asp Pro Asn Phe Phe Ala Arg Arg Lys Tyr Ser Asp Ile Ser Pro 
                85                  90                  95      


Arg Asp Pro Asn Tyr Asn Gly Leu Ala Lys Thr Leu Phe Asn Asp Arg 
            100                 105                 110         


Thr Asp Gln Glu Phe Tyr His Asp Tyr Pro Thr Ile Tyr His Leu Arg 
        115                 120                 125             


Asp Lys Leu Met Thr Ser Asp Arg Lys Phe Asp Ile Arg Glu Ile Tyr 
    130                 135                 140                 


Leu Ala Ile His His Ile Val Lys Tyr Arg Gly Asn Phe Leu Arg Thr 
145                 150                 155                 160 


Gly Pro Ala Ser Gln Tyr Gly Ser Ala Ser Leu His Leu Ala Thr Ser 
                165                 170                 175     


Phe Gln Lys Leu Asn Asp Leu Phe Ala Gln Ser Glu Glu Ser Leu Asn 
            180                 185                 190         


Phe Lys Leu Val Thr Asp Glu Ala Gln Leu Gln Gln Ile Gln Gln Ile 
        195                 200                 205             


Leu Val Arg Thr Asp Leu Ser Arg Ser Glu Gln Gln Arg Gln Ile Trp 
    210                 215                 220                 


Pro Leu Met Val Val Leu Met Gly Ala Thr Ala Ala Glu Lys Lys Arg 
225                 230                 235                 240 


Gln Lys Asp Phe Ala Lys Glu Leu Ala Asn Ala Leu Val Gly Leu Lys 
                245                 250                 255     


Ala Lys Leu Asn Val Val Thr Leu Thr Asn Val Asp Thr Thr Val Val 
            260                 265                 270         


Lys Asp Trp Thr Phe Thr Leu Glu Glu Ser Gln Asp Lys Leu Pro Glu 
        275                 280                 285             


Ile Glu Glu Gln Leu Ser Glu Val Gly Gln Gln Ile Met Asp Glu Val 
    290                 295                 300                 


Ile Gln Leu Tyr Ala Ser Val Asn Leu Ala Gln Leu Ile Pro Ala Gly 
305                 310                 315                 320 


Lys Arg Phe Ser Gln His Met Val Glu Lys Tyr Asn His His Glu Lys 
                325                 330                 335     


Asn Leu Glu Leu Leu Lys Ala Tyr Ile His Ser Gln Ser Asp Ser Lys 
            340                 345                 350         


Arg Gly Arg Glu Ile Arg Ala Thr Tyr Asp Arg Tyr Ile Asp Gly Val 
        355                 360                 365             


Lys Ser Lys Pro Val Thr Gln Glu Met Phe Tyr Lys Asp Leu Met Lys 
    370                 375                 380                 


Tyr Val Glu Ala Asp Ala Thr Ser Asn His Leu Ala Ala Glu Ile Lys 
385                 390                 395                 400 


Asp Glu Ile Asp Ser Glu Gln Phe Met Pro Lys Leu Arg Thr Lys Gln 
                405                 410                 415     


Asn Gly Ser Ile Pro Tyr Gln Val Gln Gln Tyr Glu Leu Asp Gln Ile 
            420                 425                 430         


Ile Ser His Gln Lys Lys Tyr Tyr Pro Trp Leu Gly Glu Glu Asn Pro 
        435                 440                 445             


Val Ala Glu Arg Arg Gly Lys Phe Pro Tyr Lys Leu Asp Glu Leu Val 
    450                 455                 460                 


Gly Phe Arg Val Pro Tyr Tyr Val Gly Pro Leu Ile Thr Lys Glu Asp 
465                 470                 475                 480 


Gln Gln Ala Thr Ser Gly Ala Gly Phe Ala Trp Met Val Arg Lys Ala 
                485                 490                 495     


Asp Gly Pro Ile Thr Pro Trp Asn Phe Asp Gln Lys Val Asp Arg Ile 
            500                 505                 510         


Ala Ser Ala Thr Ala Phe Ile Gln Arg Met Gln Thr Thr Asp Thr Tyr 
        515                 520                 525             


Leu Ile Gly Glu Asp Val Leu Pro Ala Arg Ser Leu Ile Tyr Gln Arg 
    530                 535                 540                 


Phe Met Val Leu Asn Glu Leu Asn Asn Met Arg Val Glu Asp Gln Lys 
545                 550                 555                 560 


Leu Ala Pro Arg Gln Lys Gln Arg Leu Tyr Asn Gln Val Phe Lys Gln 
                565                 570                 575     


His Gln His Val Ser Val Lys Asn Ile Gln Gln Asn Leu Met Asp Ala 
            580                 585                 590         


Gly Glu Tyr Arg Glu Thr Pro Lys Ile Thr Gly Leu Ala Asp Pro Lys 
        595                 600                 605             


Gly Phe Asn Ser Ser Leu Ser Thr Tyr His Asp Phe Lys Lys Ile Leu 
    610                 615                 620                 


Pro Glu Ala Ile Ala Asp Glu His Lys Arg Ala Asp Ile Glu Lys Ile 
625                 630                 635                 640 


Ile Leu Trp Ser Thr Thr Phe Glu Asp Ser Ala Ile Phe Lys Gln Lys 
                645                 650                 655     


Leu Glu Glu Val Ala Trp Leu Thr Asp Ala Gln Arg Lys Gln Leu Ser 
            660                 665                 670         


Gly Leu Arg Tyr Arg Gly Trp Gly Gln Leu Ser His Lys Leu Leu Thr 
        675                 680                 685             


Ala Phe Lys Asp Asp Asn Gly Arg Ser Val Met Asp Gly Leu Trp Glu 
    690                 695                 700                 


Thr Ser Asp Asn Phe Met Gln Leu Arg Lys Gln Pro Ala Ile Glu Thr 
705                 710                 715                 720 


Gln Ile Lys Glu Ala Asn Gln Ala Asn Leu Thr Asp Ala Asp Ile Gln 
                725                 730                 735     


Asp Thr Ile Asn Glu Leu Tyr Thr Ser Pro Gln Asn Lys Lys Ala Ile 
            740                 745                 750         


Arg Glu Val Met Leu Val Leu Asp Asp Ile Lys Asn Ala Met His Gly 
        755                 760                 765             


Gln Thr Pro Ser Trp Ile Phe Ile Glu Ala Ala Arg Gly Gly Gly Val 
    770                 775                 780                 


Ala Gly Arg Arg Thr Gln Ser Arg Ser Lys Gln Ile Val Glu Ala Tyr 
785                 790                 795                 800 


Lys Ser Thr Ala Lys Glu Ile Val Ser Glu Lys Val Gln His Glu Leu 
                805                 810                 815     


Asn Glu Lys Ile Lys Ala Lys Ala Asp Phe Asn Thr Arg Leu Val Leu 
            820                 825                 830         


Tyr Phe Leu Gln Asn Gly Arg Asp Leu Tyr Thr Asn Glu Ala Ile Asn 
        835                 840                 845             


Ile Asp Arg Leu Ser Glu Tyr Asp Ile Asp His Ile Leu Pro Gln Ser 
    850                 855                 860                 


Leu Val Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser Ala Arg 
865                 870                 875                 880 


Ile Asn Arg Glu Lys Asn Asp Thr Phe Ala Ser Glu Lys Phe Gly Arg 
                885                 890                 895     


Lys Met Gly Ala Gln Trp Arg Glu Leu His Arg Asn Gly Leu Met Thr 
            900                 905                 910         


Gln Arg Lys Leu Lys His Leu Leu Met Arg Pro Asp Glu Ile Ser Lys 
        915                 920                 925             


His Ala Thr Asp Phe Ile Asn Arg Gln Leu Val Glu Thr Arg Gln Val 
    930                 935                 940                 


Ile Lys Leu Val Glu Glu Leu Ile Ser Ser Glu Tyr Pro Ser Ala Ser 
945                 950                 955                 960 


Ile Val Ala Val Lys Ala Asn Leu Thr His Gln Phe Arg Gln Thr Phe 
                965                 970                 975     


Asn Phe Pro Lys Leu Arg Glu Val Asn Asp Tyr His His Ala Phe Asp 
            980                 985                 990         


Ala Ser Leu Thr Ala Phe Ile Gly  Met Tyr Leu Leu Lys  Gln Tyr Pro 
        995                 1000                 1005             


Lys Leu  Glu Arg Phe Phe Val  Tyr Gly Lys Phe Ala  Lys Gln Pro 
    1010                 1015                 1020             


Ile Asn  Leu Thr Arg Phe Asn  Val Ile Arg Lys Leu  Ala Val Ala 
    1025                 1030                 1035             


Glu Glu  Pro Ile Ala Asn Ile  Glu Thr Gly Glu Ile  Leu Trp Asp 
    1040                 1045                 1050             


Lys Thr  Ala Asp Ile Lys Cys  Phe Glu Lys Leu Tyr  Asn Tyr Lys 
    1055                 1060                 1065             


Arg Leu  Leu Val Thr His Glu  Val Arg Glu Asn Tyr  Gly Ala Met 
    1070                 1075                 1080             


Phe Asp  Gln Thr Ile Phe Lys  Ala Thr Asp Ser Arg  Lys Arg Leu 
    1085                 1090                 1095             


Ile Gln  Lys Lys Lys Gly Phe  Ala Thr Glu Thr Tyr  Gly Gly Tyr 
    1100                 1105                 1110             


Thr Gly  Arg Thr Leu Ala Tyr  Leu Ala Ile Val Lys  Val Val Thr 
    1115                 1120                 1125             


Asn Lys  Asp Thr Gln Tyr Gln  Val Val Gly Ile Pro  Thr Thr Met 
    1130                 1135                 1140             


Val Thr  Gln Ile Gln Gln Leu  Glu Ala Ser Gly Leu  Thr Ser Lys 
    1145                 1150                 1155             


Gln Ala  Val Thr Lys Ala Ile  Gly Ala Met Ile Asn  Glu Asn Asn 
    1160                 1165                 1170             


Lys Lys  Leu Gln Ser Tyr Glu  Val Leu Leu Pro Lys  Val Arg Phe 
    1175                 1180                 1185             


Glu Gln  Val Val Arg Asp Glu  Val Lys Gly His Ile  His Arg Phe 
    1190                 1195                 1200             


Ala Leu  Gly Thr Asp Thr Tyr  Tyr His Asn Ile Gln  Glu Leu Tyr 
    1205                 1210                 1215             


Leu Pro  Leu Thr Ile Gln Arg  Ala Phe Leu Gly Lys  Arg Asn Asp 
    1220                 1225                 1230             


Thr Asp  Ala Gln Thr Glu Gln  Asn Leu Leu Thr Val  Phe Glu Thr 
    1235                 1240                 1245             


Thr Leu  Ala Gln Val Asn Arg  Tyr Phe Pro Leu Tyr  Glu Met Asn 
    1250                 1255                 1260             


Lys Phe  Lys Gln Ile Leu Asn  Ser Ala Gln Glu Lys  Phe Ala Ala 
    1265                 1270                 1275             


Leu Pro  Thr Lys Asn Lys Thr  Val Lys Asn Lys Leu  Val Thr Gly 
    1280                 1285                 1290             


Lys Asp  Gly Val Leu Asn Asn  Leu Phe Ile Gly Leu  His Ala Asn 
    1295                 1300                 1305             


Ala Ser  Leu Gly Asp Leu Lys  Ile Leu Gly Met Lys  Ile Gly Phe 
    1310                 1315                 1320             


Gly Lys  Leu Gln Val Pro Gly  Gly Leu Lys Leu Thr  Asp Gln Ala 
    1325                 1330                 1335             


Glu Ile  Ile Tyr Gln Ser Pro  Thr Gly Leu Phe Glu  Arg Lys Val 
    1340                 1345                 1350             


Ala Leu  Lys Asp Leu 
    1355             


<210> 294
<211> 1358
<212> PRT
<213> Lactobacillus plantarum

<400> 294
Met Lys Glu Pro Tyr Gly Val Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Thr Val Val Asp Ala Ser Gly His Val Arg Lys Ile Lys Gly 
            20                  25                  30          


Gln Thr Gly Ile Gly Val Arg Leu Phe Lys Glu Gly Ala Ala Ala Ala 
        35                  40                  45              


Asp Arg Arg Gly Phe Arg Thr Thr Arg Arg Arg Leu Lys Arg Val Lys 
    50                  55                  60                  


Trp Arg Leu Arg Leu Leu Arg Glu Phe Phe Asp Gln Pro Ile Ser Lys 
65                  70                  75                  80  


Val Asp Ile Asn Phe Phe Ala Arg Arg Lys Tyr Ser Asp Val Ser Pro 
                85                  90                  95      


Arg Asp Pro Asn Tyr Asn Gly Leu Glu Lys Thr Leu Phe Asn Asp Arg 
            100                 105                 110         


Ser Asp Gln Asp Phe Tyr His Asp Tyr Pro Thr Ile Tyr His Leu Arg 
        115                 120                 125             


Glu Ala Leu Met Thr Gln His Arg Lys Phe Asp Val Arg Glu Ile Tyr 
    130                 135                 140                 


Leu Ala Ile His His Ile Val Lys Tyr Arg Gly Asn Phe Leu Arg Asn 
145                 150                 155                 160 


Asp Ala Ala Thr Ala Tyr Arg Ser Gly Thr Leu Asp Leu Gln Gln His 
                165                 170                 175     


Phe Glu Thr Leu Asn His Leu Phe Ser Gln Ala Asp Leu Glu Leu Asn 
            180                 185                 190         


Leu Asn Leu Thr Thr Asp Val Ala Leu Leu Asp Ser Ile Lys Gln Thr 
        195                 200                 205             


Leu Val Arg Thr Asp Ile Ser Arg Ser Asp Arg Gln Lys Leu Ile Met 
    210                 215                 220                 


Pro Leu Leu Ala Val Leu Thr Gly Ala Thr Thr Ala Glu Lys Lys Arg 
225                 230                 235                 240 


Gln Lys Ala Val Val Thr Glu Phe Ala Lys Ala Leu Val Gly Asn Lys 
                245                 250                 255     


Thr Lys Ile Asp Val Leu Thr Leu Thr Asp Ile Asp Ala Thr Glu Ala 
            260                 265                 270         


Lys Asp Trp Ala Phe Ser Leu Glu Glu Asn Gln Asp Lys Leu Pro Gly 
        275                 280                 285             


Ile Glu Asp Arg Phe Ser Glu Val Gly Gln Gln Ile Ile Asp Glu Val 
    290                 295                 300                 


Ile Arg Leu Tyr Ala Ser Val Asn Leu Ala Gln Leu Ile Pro Glu Gly 
305                 310                 315                 320 


Lys Arg Phe Ser Gln Ser Met Val Glu Lys Tyr Lys Arg His Gly Glu 
                325                 330                 335     


Asp Leu Lys Leu Leu Lys Ala Tyr Ile Arg Ser Gln Ser Asp Ala Lys 
            340                 345                 350         


Arg Gly Arg Ala Ile Arg Ala Thr Tyr Asp Gln Tyr Ile Asp Gly Val 
        355                 360                 365             


Lys Ser Lys Gln Val Thr Gln Glu Ala Phe Gln Lys Ala Leu Gly Lys 
    370                 375                 380                 


Phe Val Asp Ala Asp Val Asp Leu Asn Ser Trp Ala Ala Gln Ile Lys 
385                 390                 395                 400 


Gln Ala Ile Asp Ser Glu Gln Phe Met Pro Lys Leu Arg Thr Lys Gln 
                405                 410                 415     


Asn Gly Ala Ile Pro Tyr Gln Val Gln Gln Asn Glu Leu Asp Gln Ile 
            420                 425                 430         


Ile Ser Asn Gln Lys Glu Tyr Tyr Pro Trp Leu Gly Glu Glu Asn Pro 
        435                 440                 445             


Val Ile Lys Arg Arg Gly Lys Phe Pro Tyr Lys Leu Asp Glu Leu Phe 
    450                 455                 460                 


Gly Phe Arg Val Pro Tyr Tyr Val Gly Pro Leu Ile Thr Lys Glu Met 
465                 470                 475                 480 


Gln Ala Ala Thr Ala Asn Ala Gly Phe Ala Trp Met Val Arg Lys Ala 
                485                 490                 495     


Asp Gly Pro Ile Thr Pro Trp Asn Phe Asp Asp Lys Val Asp Arg Val 
            500                 505                 510         


Ala Ser Ala Thr Ala Phe Ile Gln Arg Met Gln Thr Thr Asp Thr Tyr 
        515                 520                 525             


Leu Ile Gly Glu Glu Val Leu Pro Ala Arg Ser Leu Ile Tyr Gln Arg 
    530                 535                 540                 


Phe Met Val Leu Asn Glu Leu Asn Asn Ile Arg Val Asp Asp Gly Gln 
545                 550                 555                 560 


Leu Thr Pro Arg Gln Lys Gln Arg Leu Tyr Asn Gln Val Phe Lys Lys 
                565                 570                 575     


His Lys Arg Val Thr Ala Lys Asn Ile Gln Asp Asn Leu Val Ala Ala 
            580                 585                 590         


Arg Glu Phe Pro Thr Ala Pro Arg Ile Thr Gly Leu Ala Asp Pro Lys 
        595                 600                 605             


Val Phe Asn Ser Ser Leu Ser Thr Tyr His Asp Leu Lys Gln Val Leu 
    610                 615                 620                 


Pro Glu Ala Met Ser Asp Val Arg Lys Gln Ala Asp Ile Glu Lys Ile 
625                 630                 635                 640 


Ile Leu Trp Ser Thr Ile Phe Glu Asp Ser Thr Ile Phe Lys Gln Lys 
                645                 650                 655     


Leu Thr Glu Ile Ser Trp Leu Thr Ala Ala Gln Leu Lys Gln Leu Gly 
            660                 665                 670         


Gln Leu Arg Tyr Arg Gly Trp Gly Gln Leu Leu Arg Lys Leu Leu Thr 
        675                 680                 685             


Gly Leu Lys Asp Asp Asn Asn Arg Ser Ile Met Asp Gly Leu Trp Glu 
    690                 695                 700                 


Thr Asn Ala Asn Phe Met Gln Leu Arg Ser Gln Pro Ala Ile Glu Asn 
705                 710                 715                 720 


Gln Ile Lys Ser Ala Asn Gln Ala Asn Leu Thr Thr Ala Asp Leu Gln 
                725                 730                 735     


Asp Thr Ile Asn Glu Leu Tyr Thr Ser Pro Gln Asn Lys Lys Ala Ile 
            740                 745                 750         


Arg Glu Val Met Val Val Leu Ala Asp Ile Lys Asp Ala Met His Gly 
        755                 760                 765             


Gln Thr Pro Asn Trp Ile Phe Val Glu Ala Ala Arg Gly Gly Gly Val 
    770                 775                 780                 


Ala Gly Arg Arg Thr Gln Ser Arg Ser Lys Gln Ile Val Ala Ala Tyr 
785                 790                 795                 800 


Gln Gly Thr Ala Gln Ala Ile Val Arg Asp Gln Val Gln Arg Glu Leu 
                805                 810                 815     


Lys Glu Lys Ile Lys Asn Lys Ala Asn Phe Asn Thr Arg Leu Val Leu 
            820                 825                 830         


Tyr Phe Leu Gln Asn Gly Arg Asp Leu Tyr Thr Gly Asp Ala Ile Asn 
        835                 840                 845             


Ile Asp Arg Leu Ser Glu Tyr Asp Ile Asp His Ile Leu Pro Gln Ser 
    850                 855                 860                 


Leu Val Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Asn Ala Arg 
865                 870                 875                 880 


Ile Asn Arg Glu Lys Asn Asp Thr Phe Ala Ser Glu Lys Phe Gly Lys 
                885                 890                 895     


Lys Met Gly Ala Lys Trp Lys Glu Met His Arg Met Gly Leu Met Thr 
            900                 905                 910         


Lys Arg Lys Leu Asp His Leu Leu Met Arg Pro Asp Glu Ile Ser Lys 
        915                 920                 925             


Tyr Ala Thr Gly Phe Ile Asn Arg Gln Leu Val Glu Thr Arg Gln Val 
    930                 935                 940                 


Ile Lys Leu Val Glu Glu Leu Ile Asn Ala Glu Tyr Pro Ser Thr Ala 
945                 950                 955                 960 


Ile Val Ser Val Lys Ala Asn Leu Thr His Gln Phe Arg Gln Thr Phe 
                965                 970                 975     


Asp Phe Pro Lys Ile Arg Glu Val Asn Asp Tyr His His Ala Phe Asp 
            980                 985                 990         


Ala Ala Leu Thr Ala Phe Ile Gly  Thr Tyr Leu Leu Lys  Arg Tyr Pro 
        995                 1000                 1005             


Lys Leu  Glu Arg Phe Phe Val  Tyr Gly Lys Phe Ala  Lys Gln Pro 
    1010                 1015                 1020             


Val Asn  Leu Thr Arg Phe Asn  Val Ile Arg Lys Leu  Ala Lys Thr 
    1025                 1030                 1035             


Asp Thr  Pro Ile Thr Asp Ile  Asp Thr Gly Glu Val  Leu Trp Asp 
    1040                 1045                 1050             


Lys Leu  Thr Asp Ile Lys Tyr  Phe Glu Thr Leu Tyr  Asp Tyr Lys 
    1055                 1060                 1065             


Arg Leu  Leu Val Thr Arg Glu  Val Ser Glu Asn Tyr  Gly Ala Met 
    1070                 1075                 1080             


Phe Asp  Gln Thr Leu Leu Lys  Ala Ser Asp Asn Gly  Lys Arg Leu 
    1085                 1090                 1095             


Ile Arg  Lys Lys Gln Ser Phe  Asp Thr Ala Ile Tyr  Gly Gly Tyr 
    1100                 1105                 1110             


Thr Gly  Lys Thr Leu Ala Tyr  Met Ala Ile Val Lys  Val Ser Thr 
    1115                 1120                 1125             


Lys Lys  Asp Val Gln Tyr Gln  Val Val Gly Val Pro  Thr Thr Met 
    1130                 1135                 1140             


Val Thr  Gln Ile Glu Gln Leu  Glu Gln Gln Gly Met  Thr Asn Lys 
    1145                 1150                 1155             


Gln Ala  Val Thr Lys Val Ile  Glu Pro Leu Ile Ala  Ala Asn Asn 
    1160                 1165                 1170             


Lys Lys  Met Leu Thr Tyr Glu  Val Leu Leu Pro Lys  Val Arg Phe 
    1175                 1180                 1185             


Glu Gln  Val Val Arg Asp Arg  Ile Lys Gly Gln Thr  His Arg Phe 
    1190                 1195                 1200             


Ala Leu  Gly Thr Asp Thr Tyr  Tyr His Asn Ile Gln  Glu Leu Tyr 
    1205                 1210                 1215             


Leu Pro  Leu Thr Leu Gln Arg  Ala Phe Leu Gly Lys  Gln Asn Glu 
    1220                 1225                 1230             


Ser Glu  Val Gln Leu Asn Gln  Asn Leu Leu Thr Val  Phe Asp Ala 
    1235                 1240                 1245             


Thr Leu  Ala Gln Val Asn Arg  Tyr Phe Pro Leu Tyr  Glu Met Asn 
    1250                 1255                 1260             


Lys Phe  Lys Lys Ile Leu Asn  Ser Ala Arg Asp Gln  Ile Glu Leu 
    1265                 1270                 1275             


Leu Glu  Ala Lys Asn Gln Phe  Val Lys Asn Lys Leu  Val Leu Gly 
    1280                 1285                 1290             


Lys Gln  Gly Ile Leu Thr Asn  Met Phe Ile Gly Leu  His Ala Asn 
    1295                 1300                 1305             


Ala Ser  Tyr Gly Asp Leu Lys  Val Leu Gly Val Lys  Ile Asp Phe 
    1310                 1315                 1320             


Gly Lys  Leu Gln Val Pro Gly  Gly Ile Lys Leu Thr  Gly Asp Ala 
    1325                 1330                 1335             


Glu Ile  Ile Tyr Gln Ser Pro  Thr Gly Leu Phe Glu  Arg Lys Ile 
    1340                 1345                 1350             


Ala Leu  Lys Asp Leu 
    1355             


<210> 295
<211> 1363
<212> PRT
<213> Lactobacillus rhamnosus

<400> 295
Met Thr Lys Leu Asn Gln Pro Tyr Gly Ile Gly Leu Asp Ile Gly Ser 
1               5                   10                  15      


Asn Ser Ile Gly Phe Ala Val Val Asp Ala Asn Ser His Leu Leu Arg 
            20                  25                  30          


Leu Lys Gly Glu Thr Ala Ile Gly Ala Arg Leu Phe Arg Glu Gly Gln 
        35                  40                  45              


Ser Ala Ala Asp Arg Arg Gly Ser Arg Thr Thr Arg Arg Arg Leu Ser 
    50                  55                  60                  


Arg Thr Arg Trp Arg Leu Ser Phe Leu Arg Asp Phe Phe Ala Pro His 
65                  70                  75                  80  


Ile Thr Lys Ile Asp Pro Asp Phe Phe Leu Arg Gln Lys Tyr Ser Glu 
                85                  90                  95      


Ile Ser Pro Lys Asp Lys Asp Arg Phe Lys Tyr Glu Lys Arg Leu Phe 
            100                 105                 110         


Asn Asp Arg Thr Asp Ala Glu Phe Tyr Glu Asp Tyr Pro Ser Met Tyr 
        115                 120                 125             


His Leu Arg Leu His Leu Met Thr His Thr His Lys Ala Asp Pro Arg 
    130                 135                 140                 


Glu Ile Phe Leu Ala Ile His His Ile Leu Lys Ser Arg Gly His Phe 
145                 150                 155                 160 


Leu Thr Pro Gly Ala Ala Lys Asp Phe Asn Thr Asp Lys Val Asp Leu 
                165                 170                 175     


Glu Asp Ile Phe Pro Ala Leu Thr Glu Ala Tyr Ala Gln Val Tyr Pro 
            180                 185                 190         


Asp Leu Glu Leu Thr Phe Asp Leu Ala Lys Ala Asp Asp Phe Lys Ala 
        195                 200                 205             


Lys Leu Leu Asp Glu Gln Ala Thr Pro Ser Asp Thr Gln Lys Ala Leu 
    210                 215                 220                 


Val Asn Leu Leu Leu Ser Ser Asp Gly Glu Lys Glu Ile Val Lys Lys 
225                 230                 235                 240 


Arg Lys Gln Val Leu Thr Glu Phe Ala Lys Ala Ile Thr Gly Leu Lys 
                245                 250                 255     


Thr Lys Phe Asn Leu Ala Leu Gly Thr Glu Val Asp Glu Ala Asp Ala 
            260                 265                 270         


Ser Asn Trp Gln Phe Ser Met Gly Gln Leu Asp Asp Lys Trp Ser Asn 
        275                 280                 285             


Ile Glu Thr Ser Met Thr Asp Gln Gly Thr Glu Ile Phe Glu Gln Ile 
    290                 295                 300                 


Gln Glu Leu Tyr Arg Ala Arg Leu Leu Asn Gly Ile Val Pro Ala Gly 
305                 310                 315                 320 


Met Ser Leu Ser Gln Ala Lys Val Ala Asp Tyr Gly Gln His Lys Glu 
                325                 330                 335     


Asp Leu Glu Leu Phe Lys Thr Tyr Leu Lys Lys Leu Asn Asp His Glu 
            340                 345                 350         


Leu Ala Lys Thr Ile Arg Gly Leu Tyr Asp Arg Tyr Ile Asn Gly Asp 
        355                 360                 365             


Asp Ala Lys Pro Phe Leu Arg Glu Asp Phe Val Lys Ala Leu Thr Lys 
    370                 375                 380                 


Glu Val Thr Ala His Pro Asn Glu Val Ser Glu Gln Leu Leu Asn Arg 
385                 390                 395                 400 


Met Gly Gln Ala Asn Phe Met Leu Lys Gln Arg Thr Lys Ala Asn Gly 
                405                 410                 415     


Ala Ile Pro Ile Gln Leu Gln Gln Arg Glu Leu Asp Gln Ile Ile Ala 
            420                 425                 430         


Asn Gln Ser Lys Tyr Tyr Asp Trp Leu Ala Ala Pro Asn Pro Val Glu 
        435                 440                 445             


Ala His Arg Trp Lys Met Pro Tyr Gln Leu Asp Glu Leu Leu Asn Phe 
    450                 455                 460                 


His Ile Pro Tyr Tyr Val Gly Pro Leu Ile Thr Pro Lys Gln Gln Ala 
465                 470                 475                 480 


Glu Ser Gly Glu Asn Val Phe Ala Trp Met Val Arg Lys Asp Pro Ser 
                485                 490                 495     


Gly Asn Ile Thr Pro Tyr Asn Phe Asp Glu Lys Val Asp Arg Glu Ala 
            500                 505                 510         


Ser Ala Asn Thr Phe Ile Gln Arg Met Lys Thr Thr Asp Thr Tyr Leu 
        515                 520                 525             


Ile Gly Glu Asp Val Leu Pro Lys Gln Ser Leu Leu Tyr Gln Lys Tyr 
    530                 535                 540                 


Glu Val Leu Asn Glu Leu Asn Asn Val Arg Ile Asn Asn Glu Cys Leu 
545                 550                 555                 560 


Gly Thr Asp Gln Lys Gln Arg Leu Ile Arg Glu Val Phe Glu Arg His 
                565                 570                 575     


Ser Ser Val Thr Ile Lys Gln Val Ala Asp Asn Leu Val Ala His Gly 
            580                 585                 590         


Asp Phe Ala Arg Arg Pro Glu Ile Arg Gly Leu Ala Asp Glu Lys Arg 
        595                 600                 605             


Phe Leu Ser Ser Leu Ser Thr Tyr His Gln Leu Lys Glu Ile Leu His 
    610                 615                 620                 


Glu Ala Ile Asp Asp Pro Thr Lys Leu Leu Asp Ile Glu Asn Ile Ile 
625                 630                 635                 640 


Thr Trp Ser Thr Val Phe Glu Asp His Thr Ile Phe Glu Thr Lys Leu 
                645                 650                 655     


Ala Glu Ile Glu Trp Leu Asp Pro Lys Lys Ile Asn Glu Leu Ser Gly 
            660                 665                 670         


Ile Arg Tyr Arg Gly Trp Gly Gln Phe Ser Arg Lys Leu Leu Asp Gly 
        675                 680                 685             


Leu Lys Leu Gly Asn Gly His Thr Val Ile Gln Glu Leu Met Leu Ser 
    690                 695                 700                 


Asn His Asn Leu Met Gln Ile Leu Ala Asp Glu Thr Leu Lys Glu Thr 
705                 710                 715                 720 


Met Thr Glu Leu Asn Gln Asp Lys Leu Lys Thr Asp Asp Ile Glu Asp 
                725                 730                 735     


Val Ile Asn Asp Ala Tyr Thr Ser Pro Ser Asn Lys Lys Ala Leu Arg 
            740                 745                 750         


Gln Val Leu Arg Val Val Glu Asp Ile Lys His Ala Ala Asn Gly Gln 
        755                 760                 765             


Asp Pro Ser Trp Leu Phe Ile Glu Thr Ala Asp Gly Thr Gly Thr Ala 
    770                 775                 780                 


Gly Lys Arg Thr Gln Ser Arg Gln Lys Gln Ile Gln Thr Val Tyr Ala 
785                 790                 795                 800 


Asn Ala Ala Gln Glu Leu Ile Asp Ser Ala Val Arg Gly Glu Leu Glu 
                805                 810                 815     


Asp Lys Ile Ala Asp Lys Ala Ser Phe Thr Asp Arg Leu Val Leu Tyr 
            820                 825                 830         


Phe Met Gln Gly Gly Arg Asp Ile Tyr Thr Gly Ala Pro Leu Asn Ile 
        835                 840                 845             


Asp Gln Leu Ser His Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Leu 
    850                 855                 860                 


Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Val Asn Ala Thr Ile 
865                 870                 875                 880 


Asn Arg Glu Lys Asn Asn Val Phe Ala Ser Thr Leu Phe Ala Gly Lys 
                885                 890                 895     


Met Lys Ala Thr Trp Arg Lys Trp His Glu Ala Gly Leu Ile Ser Gly 
            900                 905                 910         


Arg Lys Leu Arg Asn Leu Met Leu Arg Pro Asp Glu Ile Asp Lys Phe 
        915                 920                 925             


Ala Lys Gly Phe Val Ala Arg Gln Leu Val Glu Thr Arg Gln Ile Ile 
    930                 935                 940                 


Lys Leu Thr Glu Gln Ile Ala Ala Ala Gln Tyr Pro Asn Thr Lys Ile 
945                 950                 955                 960 


Ile Ala Val Lys Ala Gly Leu Ser His Gln Leu Arg Glu Glu Leu Asp 
                965                 970                 975     


Phe Pro Lys Asn Arg Asp Val Asn His Tyr His His Ala Phe Asp Ala 
            980                 985                 990         


Phe Leu Ala Ala Arg Ile Gly Thr  Tyr Leu Leu Lys Arg  Tyr Pro Lys 
        995                 1000                 1005             


Leu Ala  Pro Phe Phe Thr Tyr  Gly Glu Phe Ala Lys  Val Asp Val 
    1010                 1015                 1020             


Lys Lys  Phe Arg Glu Phe Asn  Phe Ile Gly Ala Leu  Thr His Ala 
    1025                 1030                 1035             


Lys Lys  Asn Ile Ile Ala Lys  Asp Thr Gly Glu Ile  Val Trp Asp 
    1040                 1045                 1050             


Lys Glu  Arg Asp Ile Arg Glu  Leu Asp Arg Ile Tyr  Asn Phe Lys 
    1055                 1060                 1065             


Arg Met  Leu Ile Thr His Glu  Val Tyr Phe Glu Thr  Ala Asp Leu 
    1070                 1075                 1080             


Phe Lys  Gln Thr Ile Tyr Ala  Ala Lys Asp Ser Lys  Glu Arg Gly 
    1085                 1090                 1095             


Gly Ser  Lys Gln Leu Ile Pro  Lys Lys Gln Gly Tyr  Pro Thr Gln 
    1100                 1105                 1110             


Val Tyr  Gly Gly Tyr Thr Gln  Glu Ser Gly Ser Tyr  Asn Ala Leu 
    1115                 1120                 1125             


Val Arg  Val Ala Glu Ala Asp  Thr Thr Ala Tyr Gln  Val Ile Lys 
    1130                 1135                 1140             


Ile Ser  Ala Gln Asn Ala Ser  Lys Ile Ala Ser Ala  Asn Leu Lys 
    1145                 1150                 1155             


Ser Arg  Glu Lys Gly Lys Gln  Leu Leu Asn Glu Ile  Val Val Lys 
    1160                 1165                 1170             


Gln Leu  Ala Lys Arg Arg Lys  Asn Trp Lys Pro Ser  Ala Asn Ser 
    1175                 1180                 1185             


Phe Lys  Ile Val Ile Pro Arg  Phe Gly Met Gly Thr  Leu Phe Gln 
    1190                 1195                 1200             


Asn Ala  Lys Tyr Gly Leu Phe  Met Val Asn Ser Asp  Thr Tyr Tyr 
    1205                 1210                 1215             


Arg Asn  Tyr Gln Glu Leu Trp  Leu Ser Arg Glu Asn  Gln Lys Leu 
    1220                 1225                 1230             


Leu Lys  Lys Leu Phe Ser Ile  Lys Tyr Glu Lys Thr  Gln Met Asn 
    1235                 1240                 1245             


His Asp  Ala Leu Gln Val Tyr  Lys Ala Ile Ile Asp  Gln Val Glu 
    1250                 1255                 1260             


Lys Phe  Phe Lys Leu Tyr Asp  Ile Asn Gln Phe Arg  Ala Lys Leu 
    1265                 1270                 1275             


Ser Asp  Ala Ile Glu Arg Phe  Glu Lys Leu Pro Ile  Asn Thr Asp 
    1280                 1285                 1290             


Gly Asn  Lys Ile Gly Lys Thr  Glu Thr Leu Arg Gln  Ile Leu Ile 
    1295                 1300                 1305             


Gly Leu  Gln Ala Asn Gly Thr  Arg Ser Asn Val Lys  Asn Leu Gly 
    1310                 1315                 1320             


Ile Lys  Thr Asp Leu Gly Leu  Leu Gln Val Gly Ser  Gly Ile Lys 
    1325                 1330                 1335             


Leu Asp  Lys Asp Thr Gln Ile  Val Tyr Gln Ser Pro  Ser Gly Leu 
    1340                 1345                 1350             


Phe Lys  Arg Arg Ile Pro Leu  Ala Asp Leu 
    1355                 1360             


<210> 296
<211> 1361
<212> PRT
<213> Lactobacillus rhamnosus


<220>
<223> Lactobacillus rhamnosus HN001

<400> 296
Met Thr Lys Leu Asn Gln Pro Tyr Gly Ile Gly Leu Asp Ile Gly Ser 
1               5                   10                  15      


Asn Ser Ile Gly Phe Ala Val Val Asp Ala Asn Ser His Leu Leu Arg 
            20                  25                  30          


Leu Lys Gly Glu Thr Ala Ile Gly Ala Arg Leu Phe Arg Glu Gly Gln 
        35                  40                  45              


Ser Ala Ala Glu Arg Arg Glu Ser Arg Thr Thr Arg Arg Arg Leu Ser 
    50                  55                  60                  


Arg Thr Arg Trp Arg Leu Ser Phe Leu Arg Asp Phe Phe Ala Pro His 
65                  70                  75                  80  


Ile Thr Lys Ile Asp Pro Asp Phe Phe Leu Arg Gln Lys Tyr Ser Glu 
                85                  90                  95      


Ile Ser Pro Lys Asp Lys Asp Arg Phe Lys Tyr Glu Lys Arg Leu Phe 
            100                 105                 110         


Asn Asp Arg Thr Asp Ala Glu Phe Tyr Glu Asp Tyr Pro Ser Met Tyr 
        115                 120                 125             


His Leu Arg Leu His Leu Met Thr His Thr His Lys Ala Asp Pro Arg 
    130                 135                 140                 


Glu Ile Phe Leu Ala Ile His His Ile Leu Lys Ser Arg Gly His Phe 
145                 150                 155                 160 


Leu Thr Pro Gly Ala Ala Lys Asp Phe Asn Thr Asp Lys Val Asp Leu 
                165                 170                 175     


Glu Asp Ile Phe Pro Ala Leu Thr Glu Ala Tyr Ala Gln Val Tyr Pro 
            180                 185                 190         


Asp Leu Glu Leu Thr Phe Asp Leu Ala Lys Ala Asp Asp Phe Lys Ala 
        195                 200                 205             


Lys Leu Leu Asp Glu Gln Ala Thr Pro Ser Asp Thr Gln Lys Ala Leu 
    210                 215                 220                 


Val Asn Leu Leu Leu Ser Ser Asp Gly Glu Lys Glu Ile Val Lys Lys 
225                 230                 235                 240 


Arg Lys Gln Val Leu Thr Glu Phe Ala Lys Ala Ile Thr Gly Leu Lys 
                245                 250                 255     


Thr Lys Phe Asn Leu Ala Leu Gly Thr Glu Val Asp Glu Ala Asp Ala 
            260                 265                 270         


Ser Asn Trp Gln Phe Ser Met Gly Gln Leu Asp Asp Lys Trp Ser Asn 
        275                 280                 285             


Ile Glu Thr Ser Met Thr Asp Gln Gly Thr Glu Ile Phe Glu Gln Ile 
    290                 295                 300                 


Gln Glu His Tyr Arg Ala Arg Leu Leu Asn Gly Ile Val Pro Ala Gly 
305                 310                 315                 320 


Met Ser Leu Ser Gln Ala Lys Val Ala Asp Tyr Gly Gln His Lys Glu 
                325                 330                 335     


Asp Leu Glu Leu Phe Lys Thr Tyr Leu Lys Lys Leu Asn Asp His Glu 
            340                 345                 350         


Leu Ala Lys Thr Ile Arg Gly Leu Tyr Asp Arg Tyr Ile Asn Gly Asp 
        355                 360                 365             


Asp Ala Lys Pro Phe Leu Arg Glu Asp Phe Val Lys Ala Leu Thr Lys 
    370                 375                 380                 


Glu Val Thr Ala His Pro Asn Glu Val Ser Glu Gln Leu Leu Asn Arg 
385                 390                 395                 400 


Met Gly Gln Ala Asn Phe Met Leu Lys Gln Arg Thr Lys Ala Asn Gly 
                405                 410                 415     


Ala Ile Pro Val Gln Leu Gln Gln Arg Glu Leu Asp Gln Ile Ile Ala 
            420                 425                 430         


Asn Gln Ser Lys Tyr Tyr Asp Trp Leu Ala Lys Pro Asn Pro Val Glu 
        435                 440                 445             


Lys His Arg Ala Ser Lys Pro Tyr Gln Leu Asp Glu Leu Leu Thr Phe 
    450                 455                 460                 


Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ile Thr Pro Lys Glu Gln Ala 
465                 470                 475                 480 


Glu Ser Arg Glu Asn Val Phe Ala Trp Met Ile Arg Lys Asp Pro Ser 
                485                 490                 495     


Gly Asn Ile Thr Pro Tyr Asn Phe Asp Glu Lys Val Asp Cys Pro Ala 
            500                 505                 510         


Ser Ala Asn Met Phe Ile Gln Arg Met Lys Asn Thr Asp Thr Tyr Leu 
        515                 520                 525             


Ile Gly Glu Asp Val Leu Pro Lys Arg Ser Leu Leu Tyr Gln Lys Tyr 
    530                 535                 540                 


Glu Val Leu Asn Glu Leu Asn Asn Val Ser Ile Asp Gly Arg Arg Leu 
545                 550                 555                 560 


Gly Ala Asp Gln Lys Gln Arg Leu Ile Arg Glu Val Phe Glu Arg His 
                565                 570                 575     


Ser Ser Val Thr Ile Lys Gln Val Ala Glu Asn Leu Val Ala His Gly 
            580                 585                 590         


Asp Phe Ala Lys Arg Pro Glu Ile Arg Gly Leu Ala Asp Glu Lys Arg 
        595                 600                 605             


Phe Leu Ser Ser Leu Ser Thr Tyr His Gln Leu Lys Lys Ile Leu His 
    610                 615                 620                 


Glu Ala Ile Asp Asp Pro Thr Lys Glu His Asp Ile Glu Asn Ile Ile 
625                 630                 635                 640 


Thr Trp Ser Thr Val Phe Glu Asp Ala Ala Ile Phe Lys Thr Glu Leu 
                645                 650                 655     


Ala Lys Ile Ser Trp Leu Asp Ser Asp Thr Ile Lys Ala Leu Ser Asn 
            660                 665                 670         


Ile Arg Tyr Arg Gly Trp Gly Gln Phe Ser Arg Lys Leu Leu Asp Gly 
        675                 680                 685             


Leu Lys Leu Gly Asn Gly His Thr Val Ile Gln Glu Leu Met Leu Ser 
    690                 695                 700                 


Asn His Asn Leu Met Gln Ile Leu Thr Asp Glu Thr Leu Lys Thr Thr 
705                 710                 715                 720 


Met Ala Glu Leu Asn Gln Asp Lys Leu Lys Ala Asp Asp Ile Glu Asp 
                725                 730                 735     


Val Ile Asn Asp Ala Tyr Thr Ser Pro Ser Asn Lys Lys Ala Leu Arg 
            740                 745                 750         


Gln Val Leu Arg Val Val Glu Asp Ile Lys His Ala Ala Asn Gly Gln 
        755                 760                 765             


Asp Pro Ser Trp Leu Tyr Ile Glu Thr Ala Asp Gly Pro Gly Thr Ala 
    770                 775                 780                 


Gly Lys Arg Thr Gln Ser Arg Gln Lys Gln Ile Gln Thr Val Tyr Ala 
785                 790                 795                 800 


Asn Ala Ala Gln Glu Leu Ile Asp Ser Ala Val Arg Gly Glu Leu Glu 
                805                 810                 815     


Asp Lys Ile Ala Asp Lys Ala Ser Phe Thr Asp Arg Leu Val Leu Tyr 
            820                 825                 830         


Phe Met Gln Gly Gly Arg Asp Ile Tyr Thr Gly Ala Pro Leu Asn Ile 
        835                 840                 845             


Asp Gln Leu Ser His Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Leu 
    850                 855                 860                 


Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Val Asn Ala Thr Ile 
865                 870                 875                 880 


Asn Arg Glu Lys Asn Asn Val Phe Ala Ser Thr Leu Phe Ala Ser Lys 
                885                 890                 895     


Met Ala Ala Thr Trp Arg Lys Trp His Glu Ala Gly Leu Ile Ser Gly 
            900                 905                 910         


Arg Lys Leu Arg Asn Leu Met Leu Arg Pro Asp Glu Ile Asp Lys Phe 
        915                 920                 925             


Ala His Gly Phe Val Ala Arg Gln Leu Val Glu Thr Arg Gln Ile Ile 
    930                 935                 940                 


Lys Leu Thr Glu Gln Ile Ala Ala Ala Gln Tyr Pro Asn Thr Lys Ile 
945                 950                 955                 960 


Ile Ala Val Lys Ala Gly Leu Ser His Gln Leu Arg Glu Glu Leu Asp 
                965                 970                 975     


Phe Pro Lys Asn Arg Asp Val Asn His Tyr His His Ala Phe Asp Ala 
            980                 985                 990         


Phe Leu Ala Ala Arg Ile Gly Thr  Tyr Leu Leu Lys Arg  Tyr Pro Lys 
        995                 1000                 1005             


Leu Ala  Pro Phe Phe Thr Tyr  Gly Glu Phe Ala Lys  Val Asp Val 
    1010                 1015                 1020             


Lys Lys  Phe Arg Glu Phe Asn  Phe Ile Gly Ala Leu  Thr His Ala 
    1025                 1030                 1035             


Lys Lys  Asn Ile Val Ala Lys  Asp Thr Gly Glu Ile  Val Trp Asp 
    1040                 1045                 1050             


Lys Glu  Arg Asp Ile Gln Glu  Leu Asp Arg Ile Tyr  Asn Phe Lys 
    1055                 1060                 1065             


Arg Met  Leu Ile Thr His Glu  Val Tyr Phe Glu Thr  Ala Asp Leu 
    1070                 1075                 1080             


Phe Lys  Gln Thr Ile Tyr Ala  Ala Lys Asp Ser Lys  Glu Arg Gly 
    1085                 1090                 1095             


Gly Ser  Lys Gln Leu Ile Pro  Lys Lys Gln Gly Tyr  Pro Thr Gln 
    1100                 1105                 1110             


Val Tyr  Gly Gly Tyr Thr Arg  Glu Asn Thr Ala Tyr  Leu Ala Val 
    1115                 1120                 1125             


Val Lys  Thr Val Glu Lys Lys  Ala Asp Val Tyr Arg  Val Val Arg 
    1130                 1135                 1140             


Ile Ala  Thr Ser Gln Val Ala  Ala Leu Lys Glu Ala  Arg Ala Gln 
    1145                 1150                 1155             


Ser Thr  Val Lys Glu Arg Glu  Leu Leu Lys Lys Phe  Leu Thr Thr 
    1160                 1165                 1170             


Lys Phe  Thr Lys Ile Gly Lys  Asn Gly Lys Lys Ala  Ile Thr Pro 
    1175                 1180                 1185             


Phe Asp  Ile Val Ile Pro Arg  Val Pro Arg Glu Gln  Leu Phe His 
    1190                 1195                 1200             


Asn Lys  Arg Tyr Gly Phe Phe  Met Val Asn Ser Asp  Thr Leu Met 
    1205                 1210                 1215             


His Asn  Tyr Gln Glu Leu Trp  Met Ser Arg Ser Asp  Gln Gln Ile 
    1220                 1225                 1230             


Leu Ser  Lys Leu Val Lys Ser  Ala Lys Thr Val Glu  Asn Gly Gln 
    1235                 1240                 1245             


Val Gly  Arg Leu Phe Glu Asn  Ile Val Glu Gln Ile  Asn Lys Tyr 
    1250                 1255                 1260             


Phe Pro  Leu Tyr Asp Ile Asn  Gln Phe Arg Lys Lys  Leu Asp Gln 
    1265                 1270                 1275             


Ser Lys  Asp Ile Phe Ser Lys  Leu Pro Leu Glu Gly  Asn Gly Thr 
    1280                 1285                 1290             


Thr Ser  Gly Lys Arg Glu Thr  Ile Gln Asn Ile Leu  Thr Gly Ala 
    1295                 1300                 1305             


Gly Thr  Gly Ala Lys Asn Gly  Asp Leu Lys Asn Leu  Gly Ile Lys 
    1310                 1315                 1320             


Thr Pro  Phe Gly Phe Leu Gln  Val Pro Ser Gly Ile  Val Leu Asp 
    1325                 1330                 1335             


Asp Asp  Thr Thr Leu Ile Tyr  Gln Ser Pro Thr Gly  Met Leu Asn 
    1340                 1345                 1350             


Arg Ile  Val Arg Leu Ser Glu  Leu 
    1355                 1360     


<210> 297
<211> 1361
<212> PRT
<213> Lactobacillus rhamnosus


<220>
<223> Lactobacillus rhamnosus R0011

<400> 297
Met Thr Lys Leu Asn Gln Pro Tyr Gly Ile Gly Leu Asp Ile Gly Ser 
1               5                   10                  15      


Asn Ser Ile Gly Phe Ala Val Val Asp Ala Asn Ser His Leu Leu Arg 
            20                  25                  30          


Leu Lys Gly Glu Thr Ala Ile Gly Ala Arg Leu Phe Arg Glu Gly Gln 
        35                  40                  45              


Ser Ala Ala Glu Arg Arg Glu Ser Arg Thr Thr Arg Arg Arg Leu Ser 
    50                  55                  60                  


Arg Thr Arg Trp Arg Leu Ser Phe Leu Arg Asp Phe Phe Ala Pro His 
65                  70                  75                  80  


Ile Thr Lys Ile Asp Pro Asp Phe Phe Leu Arg Gln Lys Tyr Ser Glu 
                85                  90                  95      


Ile Ser Pro Lys Asp Lys Asp Arg Phe Lys Tyr Glu Lys Arg Leu Phe 
            100                 105                 110         


Asn Asp Arg Thr Asp Ala Glu Phe Tyr Glu Asp Tyr Pro Ser Met Tyr 
        115                 120                 125             


His Leu Arg Leu His Leu Met Thr His Thr His Lys Ala Asp Pro Arg 
    130                 135                 140                 


Glu Ile Phe Leu Ala Ile His His Ile Leu Lys Ser Arg Gly His Phe 
145                 150                 155                 160 


Leu Thr Pro Gly Ala Ala Lys Asp Phe Asn Thr Asp Lys Val Asp Leu 
                165                 170                 175     


Glu Asp Ile Phe Pro Ala Leu Thr Glu Ala Tyr Ala Gln Val Tyr Pro 
            180                 185                 190         


Asp Leu Glu Leu Thr Phe Asp Leu Ala Lys Ala Asp Asp Phe Lys Ala 
        195                 200                 205             


Lys Leu Leu Asp Glu Gln Ala Thr Pro Ser Asp Thr Gln Lys Ala Leu 
    210                 215                 220                 


Val Asn Leu Leu Leu Ser Ser Asp Gly Glu Lys Glu Ile Val Lys Lys 
225                 230                 235                 240 


Arg Lys Gln Val Leu Thr Glu Phe Ala Lys Ala Ile Thr Gly Leu Lys 
                245                 250                 255     


Thr Lys Phe Asn Leu Ala Leu Gly Thr Glu Val Asp Glu Ala Asp Ala 
            260                 265                 270         


Ser Asn Trp Gln Phe Ser Met Gly Gln Leu Asp Asp Lys Trp Ser Asn 
        275                 280                 285             


Ile Glu Thr Ser Met Thr Asp Gln Gly Thr Glu Ile Phe Glu Gln Ile 
    290                 295                 300                 


Gln Glu Leu Tyr Arg Ala Arg Leu Leu Asn Gly Ile Val Pro Ala Gly 
305                 310                 315                 320 


Met Ser Leu Ser Gln Ala Lys Val Ala Asp Tyr Gly Gln His Lys Glu 
                325                 330                 335     


Asp Leu Glu Leu Phe Lys Thr Tyr Leu Lys Lys Leu Asn Asp His Glu 
            340                 345                 350         


Leu Ala Lys Thr Ile Arg Gly Leu Tyr Asp Arg Tyr Ile Asn Gly Asp 
        355                 360                 365             


Asp Ala Lys Pro Phe Leu Arg Glu Asp Phe Val Lys Ala Leu Thr Lys 
    370                 375                 380                 


Glu Val Thr Ala His Pro Asn Glu Val Ser Glu Gln Leu Leu Asn Arg 
385                 390                 395                 400 


Met Gly Gln Ala Asn Phe Met Leu Lys Gln Arg Thr Lys Ala Asn Gly 
                405                 410                 415     


Ala Ile Pro Val Gln Leu Gln Gln Arg Glu Leu Asp Gln Ile Ile Ala 
            420                 425                 430         


Asn Gln Ser Lys Tyr Tyr Asp Trp Leu Ala Lys Pro Asn Pro Val Glu 
        435                 440                 445             


Lys His Arg Ala Ser Lys Pro Tyr Gln Leu Asp Glu Leu Leu Thr Phe 
    450                 455                 460                 


Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ile Thr Pro Lys Glu Gln Ala 
465                 470                 475                 480 


Glu Ser Arg Glu Asn Val Phe Ala Trp Met Ile Arg Lys Asp Pro Ser 
                485                 490                 495     


Gly Asn Ile Thr Pro Tyr Asn Phe Asp Glu Lys Val Asp Cys Pro Ala 
            500                 505                 510         


Ser Ala Asn Met Phe Ile Gln Arg Met Lys Asn Thr Asp Thr Tyr Leu 
        515                 520                 525             


Ile Gly Glu Asp Val Leu Pro Lys Arg Ser Leu Leu Tyr Gln Lys Tyr 
    530                 535                 540                 


Glu Val Leu Asn Glu Leu Asn Asn Val Ser Ile Asp Gly Arg Arg Leu 
545                 550                 555                 560 


Gly Ala Asp Gln Lys Gln Arg Leu Ile Arg Glu Val Phe Glu Arg His 
                565                 570                 575     


Ser Ser Val Thr Ile Lys Gln Val Ala Glu Asn Leu Val Ala His Gly 
            580                 585                 590         


Asp Phe Ala Lys Arg Pro Glu Ile Arg Gly Leu Ala Asp Glu Lys Arg 
        595                 600                 605             


Phe Leu Ser Ser Leu Ser Thr Tyr His Gln Leu Lys Lys Ile Leu His 
    610                 615                 620                 


Glu Ala Ile Asp Asp Pro Thr Lys Glu His Asp Ile Glu Asn Ile Ile 
625                 630                 635                 640 


Thr Trp Ser Thr Val Phe Glu Asp Ala Ala Ile Phe Lys Thr Glu Leu 
                645                 650                 655     


Ala Lys Ile Ser Trp Leu Asp Ser Asp Thr Ile Lys Ala Leu Ser Asn 
            660                 665                 670         


Ile Arg Tyr Arg Gly Trp Gly Gln Phe Ser Arg Lys Leu Leu Asp Gly 
        675                 680                 685             


Leu Lys Leu Gly Asn Gly His Thr Val Ile Gln Glu Leu Met Leu Ser 
    690                 695                 700                 


Asn His Asn Leu Met Gln Ile Leu Thr Asp Glu Thr Leu Lys Thr Thr 
705                 710                 715                 720 


Met Ala Glu Leu Asn Gln Asp Lys Leu Lys Ala Asp Asp Ile Glu Asp 
                725                 730                 735     


Val Ile Asn Asp Ala Tyr Thr Ser Pro Ser Asn Lys Lys Ala Leu Arg 
            740                 745                 750         


Gln Val Leu Arg Val Val Glu Asp Ile Lys His Ala Ala Asn Gly Gln 
        755                 760                 765             


Asp Pro Ser Trp Leu Tyr Ile Glu Thr Ala Asp Gly Pro Gly Thr Ala 
    770                 775                 780                 


Gly Lys Arg Thr Gln Ser Arg Gln Lys Gln Ile Gln Thr Val Tyr Ala 
785                 790                 795                 800 


Asn Ala Ala Gln Glu Leu Ile Asp Ser Ala Val Arg Gly Glu Leu Glu 
                805                 810                 815     


Asp Lys Ile Ala Asp Lys Ala Ser Phe Thr Asp Arg Leu Val Leu Tyr 
            820                 825                 830         


Phe Met Gln Gly Gly Arg Asp Ile Tyr Thr Gly Ala Pro Leu Asn Ile 
        835                 840                 845             


Asp Gln Leu Ser His Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Leu 
    850                 855                 860                 


Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Val Asn Ala Thr Ile 
865                 870                 875                 880 


Asn Arg Glu Lys Asn Asn Val Phe Ala Ser Thr Leu Phe Ala Ser Lys 
                885                 890                 895     


Met Ala Ala Thr Trp Arg Lys Trp His Glu Ala Gly Leu Ile Ser Gly 
            900                 905                 910         


Arg Lys Leu Arg Asn Leu Met Leu Arg Pro Asp Glu Ile Asp Lys Phe 
        915                 920                 925             


Ala His Gly Phe Val Ala Arg Gln Leu Val Glu Thr Arg Gln Ile Ile 
    930                 935                 940                 


Lys Leu Thr Glu Gln Ile Ala Ala Ala Gln Tyr Pro Asn Thr Lys Ile 
945                 950                 955                 960 


Ile Ala Val Lys Ala Gly Leu Ser His Gln Leu Arg Glu Glu Leu Asp 
                965                 970                 975     


Phe Pro Lys Asn Arg Asp Val Asn His Tyr His His Ala Phe Asp Ala 
            980                 985                 990         


Phe Leu Ala Ala Arg Ile Gly Thr  Tyr Leu Leu Lys Arg  Tyr Pro Lys 
        995                 1000                 1005             


Leu Ala  Pro Phe Phe Thr Tyr  Gly Glu Phe Ala Lys  Val Asp Val 
    1010                 1015                 1020             


Lys Lys  Phe Arg Glu Phe Asn  Phe Ile Gly Ala Leu  Thr His Ala 
    1025                 1030                 1035             


Lys Lys  Asn Ile Val Ala Lys  Asp Thr Gly Glu Ile  Val Trp Asp 
    1040                 1045                 1050             


Lys Glu  Arg Asp Ile Gln Glu  Leu Asp Arg Ile Tyr  Asn Phe Lys 
    1055                 1060                 1065             


Arg Met  Leu Ile Thr His Glu  Val Tyr Phe Glu Thr  Ala Asp Leu 
    1070                 1075                 1080             


Phe Lys  Gln Thr Ile Tyr Ala  Ala Lys Asp Ser Lys  Glu Arg Gly 
    1085                 1090                 1095             


Gly Ser  Lys Gln Leu Ile Pro  Lys Lys Gln Gly Tyr  Pro Thr Gln 
    1100                 1105                 1110             


Val Tyr  Gly Gly Tyr Thr Arg  Glu Asn Thr Ala Tyr  Leu Ala Val 
    1115                 1120                 1125             


Val Lys  Thr Val Glu Lys Lys  Ala Asp Val Tyr Arg  Val Val Arg 
    1130                 1135                 1140             


Ile Ala  Thr Ser Gln Val Ala  Ala Leu Lys Glu Ala  Arg Ala Gln 
    1145                 1150                 1155             


Ser Thr  Val Lys Glu Arg Glu  Leu Leu Lys Lys Phe  Leu Thr Thr 
    1160                 1165                 1170             


Lys Phe  Thr Lys Ile Gly Lys  Asn Gly Lys Lys Ala  Ile Thr Pro 
    1175                 1180                 1185             


Phe Asp  Ile Val Ile Pro Arg  Val Pro Arg Glu Gln  Leu Phe His 
    1190                 1195                 1200             


Asn Lys  Arg Tyr Gly Phe Phe  Met Val Asn Ser Asp  Thr Leu Met 
    1205                 1210                 1215             


His Asn  Tyr Gln Glu Leu Trp  Met Ser Arg Ser Asp  Gln Gln Ile 
    1220                 1225                 1230             


Leu Ser  Lys Leu Val Lys Ser  Ala Lys Thr Val Glu  Asn Gly Gln 
    1235                 1240                 1245             


Val Gly  Arg Leu Phe Glu Asn  Ile Val Glu Gln Ile  Asn Lys Tyr 
    1250                 1255                 1260             


Phe Pro  Leu Tyr Asp Ile Asn  Gln Phe Arg Lys Lys  Leu Asp Gln 
    1265                 1270                 1275             


Ser Lys  Asp Ile Phe Ser Lys  Leu Pro Leu Glu Gly  Asn Gly Thr 
    1280                 1285                 1290             


Thr Ser  Gly Lys Arg Glu Thr  Ile Gln Asn Ile Leu  Thr Gly Ala 
    1295                 1300                 1305             


Gly Thr  Gly Ala Lys Asn Gly  Asp Leu Lys Asn Leu  Gly Ile Lys 
    1310                 1315                 1320             


Thr Pro  Phe Gly Phe Leu Gln  Val Pro Ser Gly Ile  Val Leu Asp 
    1325                 1330                 1335             


Asp Asp  Thr Thr Leu Ile Tyr  Gln Ser Pro Thr Gly  Met Leu Asn 
    1340                 1345                 1350             


Arg Ile  Val Arg Leu Ser Glu  Leu 
    1355                 1360     


<210> 298
<211> 1375
<212> PRT
<213> Lactobacillus ruminis


<220>
<223> Lactobacillus ruminis ATCC 25644

<400> 298
Met Arg Lys Asn Gln Glu Pro Tyr Asn Ile Gly Leu Asp Ile Gly Thr 
1               5                   10                  15      


Ser Ser Ile Gly Trp Ser Ile Met Asn Asp Asn Phe Asp Leu Met Arg 
            20                  25                  30          


Val Lys Gly Lys Lys Gly Ile Gly Val Arg Leu Tyr Asn Glu Gly Gln 
        35                  40                  45              


Ser Ala Ala Glu Arg Arg Met His Arg Thr Ala Arg Arg Arg Tyr Gly 
    50                  55                  60                  


Arg Arg Lys Trp Arg Leu Arg Leu Leu Glu Asp Phe Phe Asp Glu His 
65                  70                  75                  80  


Met Ala Glu Val Asp Asp Thr Phe Phe Ala Arg Leu Lys Asp Ser Asn 
                85                  90                  95      


Ile Ser Pro Lys Asp Asp Lys Lys Tyr Arg Lys Ser Leu Leu Phe Pro 
            100                 105                 110         


Lys Ser Lys Gly Val Thr Tyr Gln Asp Asp Gly Glu Phe Tyr Lys Lys 
        115                 120                 125             


Tyr Pro Thr Met Tyr His Leu Arg Tyr Ala Leu Met Thr Glu His Arg 
    130                 135                 140                 


Lys Phe Asp Leu Arg Glu Ile Tyr Leu Ala Phe His His Met Val Lys 
145                 150                 155                 160 


Tyr Arg Gly Asn Phe Leu Tyr Asp Thr Ser Val Asp Ser Phe Glu Ala 
                165                 170                 175     


Lys Asn Leu Asp Ile Lys Gly Lys Phe Asp Glu Ile Asn Asp Leu Leu 
            180                 185                 190         


Ser Ser Tyr Thr Asp Phe Tyr Val Asp Asn Ser Asn Ala Ala Leu Val 
        195                 200                 205             


Glu Ser Ile Leu Leu Glu Lys Asn Thr Thr Arg Lys Asp Lys Ser Lys 
    210                 215                 220                 


Lys Ile Ala Lys Leu Leu His Val Glu Asp Lys Glu Lys Gly Lys Asn 
225                 230                 235                 240 


Lys Lys Ala Lys Asp Leu Ala Thr Gln Ile Ser Asn Ala Val Leu Gly 
                245                 250                 255     


Leu Lys Cys Asn Phe His Leu Ile Phe Glu Leu Gln Gln Lys Tyr Ser 
            260                 265                 270         


Phe Asp Leu Cys Ser Glu Lys Thr Glu Glu Asn Ile Ala Lys Leu Ser 
        275                 280                 285             


Glu Val Leu Asp Glu Asn Gln Lys Met Leu Leu Met Ile Leu Lys Glu 
    290                 295                 300                 


Val Gln Asp Gln Val Met Leu Asn Ala Phe Val Pro Ser Gly Met Ser 
305                 310                 315                 320 


Leu Ser Glu Ala Met Met Gln Lys Tyr Asp Asp Tyr Gly Glu Gln Leu 
                325                 330                 335     


Lys Ile Tyr His Glu Leu Glu His Ser Val Ser Asp Asp Ser Ala Ala 
            340                 345                 350         


Lys Leu Arg Gly Ala Tyr Arg Asp Tyr Asn Asp Asn Ile Ile Lys Arg 
        355                 360                 365             


Ile Asp Gly Asp Asn Lys Lys Asp Thr Phe Tyr Lys Arg Val Lys Asn 
    370                 375                 380                 


Ile Leu Thr Lys Ile Ser Lys Glu Tyr Val Asp Gln Asp Val Leu Glu 
385                 390                 395                 400 


Ser Cys Gly Lys Leu Lys Lys Leu Ile Asp Glu Asn Lys Leu Phe Ile 
                405                 410                 415     


Arg Gln Arg Thr Ala Ala Asn Gly Val Leu Pro His Gln Leu His Gln 
            420                 425                 430         


Ile Glu Met Arg Lys Ile Ile Asp Asn Gln Lys Glu Tyr Tyr Pro Trp 
        435                 440                 445             


Leu Ala Glu Pro Asn Pro Asn Glu Lys Arg Arg Val Tyr Ser Lys Tyr 
    450                 455                 460                 


Lys Val Glu Glu Leu Ile Ala Phe Arg Ile Pro Tyr Tyr Val Gly Pro 
465                 470                 475                 480 


Leu Val Asp Pro Asn Asn Ala Asp Lys Asn Lys Glu Ala Arg Phe Ser 
                485                 490                 495     


Trp Met Val Arg Lys Lys Asp Gly Glu Ile Thr Pro Trp Asn Phe Tyr 
            500                 505                 510         


Asp Lys Val Asp Trp Ala Glu Ser Ala Asn Asn Phe Ile Glu Arg Met 
        515                 520                 525             


Lys Ser Lys Asp Thr Tyr Leu Leu Gly Glu Asp Val Val Pro Lys Glu 
    530                 535                 540                 


Ser Met Leu Tyr Gln Lys Tyr Glu Val Leu Asn Glu Leu Asn Asn Leu 
545                 550                 555                 560 


Arg Ile Asn Asp Ser Gly Leu Ser Asp Ser Phe Glu Asp Val Lys Leu 
                565                 570                 575     


Lys Gln Ala Ile Tyr Asn Asp Leu Phe Lys Lys Gln Lys Ile Val Lys 
            580                 585                 590         


Ile Thr Asp Leu Gln Asn Tyr Leu Val Gln Asn His Lys Tyr Leu Val 
        595                 600                 605             


Lys Pro Lys Ile Ser Gly Leu Ala Asp Glu Asn Arg Phe Leu Ser Ser 
    610                 615                 620                 


Leu Ser Thr Tyr Ser Asp Leu Lys Thr Ile Phe Gly Asp Lys Val Asp 
625                 630                 635                 640 


Asp Arg Thr Tyr Phe Asn Asp Phe Glu Lys Met Val Glu Tyr Ser Thr 
                645                 650                 655     


Val Phe Glu Asp Gly His Asp Tyr Asn Gln Lys Leu Asp Glu Tyr Thr 
            660                 665                 670         


Trp Leu Thr Lys Glu Glu Lys Tyr Lys Ile Gly Lys Lys Arg Tyr Arg 
        675                 680                 685             


Gly Trp Gly Lys Leu Ser Lys Lys Leu Leu Thr Gly Leu Arg Asp Lys 
    690                 695                 700                 


Asn Asn His Thr Ile Met Asp Asn Leu Trp Glu Thr Asn Arg Asn Phe 
705                 710                 715                 720 


Met Gln Ile Gln Thr Ala Asp Glu Phe Ser Lys Gln Ile Ala Glu Glu 
                725                 730                 735     


Asn Glu Arg His Leu Lys Gly Ser Val Ser Asp Ala Ile Asn Asp Met 
            740                 745                 750         


Tyr Thr Ser Pro Ala Asn Lys Lys Ala Ile Arg Gln Val Leu Arg Val 
        755                 760                 765             


Val Asp Asp Ile Gln Lys Ala Met Gly Tyr Ala Pro Ser Ser Ile Ser 
    770                 775                 780                 


Leu Glu Phe Ala Arg Glu Asp Gly Pro Ser Val Arg Thr Val Ser Arg 
785                 790                 795                 800 


Ala Asn Arg Met Lys Ser Ile Tyr Glu Lys Tyr Ala Ser Glu Val Ser 
                805                 810                 815     


Glu Glu Val Met Lys Asp Leu Asp Gly Val Ile Lys Asp Lys Lys Gly 
            820                 825                 830         


Leu Asn Asp Arg Leu Tyr Leu Tyr Phe Glu Gln Gln Gly Lys Asp Met 
        835                 840                 845             


Tyr Ser Gly His Pro Leu Asp Phe Asp Lys Val Ile Ser Gly Gln Glu 
    850                 855                 860                 


Tyr Asp Ile Asp His Ile Leu Pro Gln Ala Val Ile Lys Asp Asp Ser 
865                 870                 875                 880 


Leu Asp Asn Arg Val Leu Thr Thr Lys Ala Leu Asn Asn Asp Val Lys 
                885                 890                 895     


Ser Lys Gly Val Pro Cys Arg Met Phe Asn Gly Met His Ser Phe Trp 
            900                 905                 910         


Lys Asn Leu Tyr Asp Lys Gly Phe Ile Ser Arg Arg Lys Phe Asn Asn 
        915                 920                 925             


Leu Thr Thr Asn Pro Glu Asn Ile Asp Lys Tyr Lys Met Lys Gly Phe 
    930                 935                 940                 


Val Asn Arg Gln Leu Val Glu Thr Arg Gln Ile Ile Lys Leu Val Ala 
945                 950                 955                 960 


Asn Val Leu Asn Asp Lys Tyr Gln Asn Asp Asp Val Asp Ile Ile Glu 
                965                 970                 975     


Val Arg Ala Glu Leu Thr His Asp Val Arg Lys His Phe Lys Phe Tyr 
            980                 985                 990         


Lys Asn Arg Asn Val Asn Asp Tyr  His His Ala Phe Asp  Ala Tyr Leu 
        995                 1000                 1005             


Thr Ser  Phe Ile Gly His Tyr  Leu Phe Lys Lys Tyr  Pro Asn Leu 
    1010                 1015                 1020             


Arg Pro  Leu Phe Asp Tyr Asn  Asp Phe Met Lys Val  Ser Asp Asn 
    1025                 1030                 1035             


Val Phe  Lys Gln Leu Arg Gly  Asn Asn Phe Leu Gly  Glu Phe Leu 
    1040                 1045                 1050             


Asn Lys  Thr Gly Asp Ile Ile  Ser Thr Asp Gly Asn  Phe Val Leu 
    1055                 1060                 1065             


Asn Lys  Glu Glu Met Ile Asn  Lys Leu Asn Lys Ala  Tyr Ala Phe 
    1070                 1075                 1080             


Lys Lys  Ile Leu Val Thr Lys  Glu Val Gly Gln Arg  Thr Gly Ala 
    1085                 1090                 1095             


Met Phe  Asn Glu Thr Arg Tyr  Pro Ala Pro Asn Ser  Arg Lys Ala 
    1100                 1105                 1110             


Ala Leu  Lys Tyr Arg Arg Met  Pro Lys Pro Asp Ser  Leu Ile Ser 
    1115                 1120                 1125             


Val Lys  Asp Tyr Lys Asn Thr  Asp Ile Tyr Gly Gly  Tyr Ser Gly 
    1130                 1135                 1140             


Lys Asn  Asp Ala Tyr Met Val  Ile Val Asp Met Gly  Lys Gln Tyr 
    1145                 1150                 1155             


Met Val  Val Gly Val Pro Val  Arg Tyr Thr Glu Lys  Leu Asp Lys 
    1160                 1165                 1170             


Leu Arg  Ile Lys His Ser Glu  Leu Tyr Arg Asp Glu  Leu Arg Lys 
    1175                 1180                 1185             


Val Leu  Ser Arg Asp Lys Thr  Leu Leu Asp Ser Lys  Gly Asn Val 
    1190                 1195                 1200             


Lys Arg  Phe Asp Ile Val Leu  Asp Arg Val Leu Tyr  Gly Gln Leu 
    1205                 1210                 1215             


Ile Glu  Asp Gly Asn Glu Leu  Phe Thr Leu Gly Ser  Ser Lys Tyr 
    1220                 1225                 1230             


Lys Arg  Asn Phe Arg Gln Leu  Phe Leu Asp Lys Gln  Cys Ile Glu 
    1235                 1240                 1245             


Ile Leu  Asp Ser Ser Ala Thr  Pro Gln Pro Thr Asp  Glu Glu Leu 
    1250                 1255                 1260             


Ile Trp  Val Tyr Asp Gln Ile  Leu Asp Lys Val Asp  Lys Tyr Phe 
    1265                 1270                 1275             


Glu Leu  Tyr Asp Ile Asn Arg  Gln Arg Glu Thr Leu  Arg Lys Gly 
    1280                 1285                 1290             


Arg Ala  Ala Phe Cys Ser Leu  Pro Asn Ile Ser Met  Lys Lys Asp 
    1295                 1300                 1305             


Asp Val  Thr Lys Lys Lys Ile  Leu Asn Glu Ile Leu  Val Ala Leu 
    1310                 1315                 1320             


His Ala  Asn Glu Ser Glu Ser  Asn Cys Glu Lys Ile  Gly Lys Lys 
    1325                 1330                 1335             


Val Phe  Gly Arg Leu Gln Val  Pro Gly Gly Ile Lys  Leu Ser Lys 
    1340                 1345                 1350             


Glu Ala  Lys Leu Ile Tyr Gln  Ser Pro Thr Gly Leu  Phe Glu Arg 
    1355                 1360                 1365             


Val Val  Tyr Leu Lys Asp Leu  
    1370                 1375 


<210> 299
<211> 1339
<212> PRT
<213> Lactobacillus salivarius


<220>
<223> Lactobacillus salivarius SMXD51

<400> 299
Met Glu Arg Tyr His Ile Gly Leu Asp Ile Gly Thr Ser Ser Ile Gly 
1               5                   10                  15      


Trp Ala Val Ile Gly Asp Asp Phe Lys Ile Lys Lys Lys Lys Gly Lys 
            20                  25                  30          


Asn Leu Ile Gly Thr Arg Leu Phe Asn Glu Gly Ala Thr Ala Ala Glu 
        35                  40                  45              


Arg Arg Gly Phe Arg Thr Gln Arg Arg Arg Leu Asn Arg Arg Lys Trp 
    50                  55                  60                  


Arg Leu Lys Leu Leu Glu Glu Ile Phe Asp Pro Tyr Met Ala Glu Val 
65                  70                  75                  80  


Asp Glu Tyr Phe Phe Ala Arg Leu Lys Ser Ser Asn Leu Ser Pro Lys 
                85                  90                  95      


Asp Ser Asn Lys Lys Tyr Leu Gly Ser Leu Leu Phe Pro Asp Lys Ser 
            100                 105                 110         


Asp Ser Asn Phe Tyr Asp Lys Tyr Pro Thr Ile Tyr His Leu Arg Arg 
        115                 120                 125             


Asp Leu Met Glu Lys Asp Glu Lys Phe Asp Leu Arg Glu Ile Tyr Leu 
    130                 135                 140                 


Ala Ile His His Ile Val Lys Tyr Arg Gly Asn Phe Leu Glu Lys Val 
145                 150                 155                 160 


Pro Ala Lys Asn Tyr Lys Asn Ser Gly Ala Ser Ile Gly Phe Leu Leu 
                165                 170                 175     


Glu Glu Val Asn Ser Leu Tyr Lys Asp Ile Ile Gly Asp Glu Ser Ile 
            180                 185                 190         


Ala Ile Leu Asn Ser Glu Lys Phe Glu Asp Val Glu Lys Ile Ile Leu 
        195                 200                 205             


Asp Glu Glu Thr Arg Asn Leu Asp Lys Gln Lys Ser Val Gly Lys Leu 
    210                 215                 220                 


Leu Val Glu Asp Lys Lys Lys Lys Asn Ile Val Thr Ala Phe Ser Lys 
225                 230                 235                 240 


Ala Ile Phe Gly Tyr Lys Phe Asn Ile Glu Asp Leu Leu Leu Ile Glu 
                245                 250                 255     


Asn Asp Glu Lys Asn Lys Leu Thr Phe Asn Asp Glu Asn Ile Asp Asp 
            260                 265                 270         


Ile Phe Asn Glu Leu Ser His Ser Leu Asp Asp Lys Gln Met Asp Leu 
        275                 280                 285             


Leu Thr Lys Thr Arg Glu Ile Tyr Phe Lys Phe Lys Leu Asn Met Ile 
    290                 295                 300                 


Val Pro Thr Gly Tyr Thr Leu Ser Glu Ser Met Ile Glu Lys Tyr Glu 
305                 310                 315                 320 


Met His Lys Ala His Leu Lys Met Tyr Lys Glu Phe Ile Asn Thr Leu 
                325                 330                 335     


Asn Thr Lys Asp Arg Lys Ile Leu Lys Asn Ala Tyr Ser Asp Tyr Ile 
            340                 345                 350         


Asn Thr Glu Lys Ala Lys Ala Ala Asn Ala Gln Glu Asn Phe Tyr Lys 
        355                 360                 365             


Thr Val Lys Lys Ile Ile Lys Asp Asn Asn Ser Asp Thr Ala Lys Lys 
    370                 375                 380                 


Ile Ile Val Leu Ile Asp Glu Gly Asn Phe Met Pro Lys Gln Arg Thr 
385                 390                 395                 400 


Gly Glu Asn Gly Val Ile Pro His Gln Leu His Gln Ile Glu Leu Asp 
                405                 410                 415     


Arg Ile Ile Glu Asn Gln Ala Lys Tyr Tyr Pro Trp Leu Ala Glu Ala 
            420                 425                 430         


Asn Pro Val Glu Lys Asn Arg Lys Phe Ala Lys Tyr Lys Leu Asp Glu 
        435                 440                 445             


Leu Val Thr Phe Arg Val Pro Tyr Tyr Val Gly Pro Leu Ile Asp Lys 
    450                 455                 460                 


Thr Glu Ser Asn Lys Asn Glu Lys Glu Thr Lys Phe Ala Trp Met Val 
465                 470                 475                 480 


Arg Lys Ala Lys Gly Thr Ile Thr Pro Trp Asn Phe Glu Asn Leu Val 
                485                 490                 495     


Asp Arg Thr Glu Ser Ala Asn Arg Phe Ile Lys Arg Met Thr Ser Lys 
            500                 505                 510         


Asp Thr Tyr Ile Ile Gly Glu Asp Val Leu Pro Ala Ser Ser Leu Leu 
        515                 520                 525             


Tyr Glu Lys Phe Lys Val Leu Asn Glu Leu Asn Asn Ile Lys Val Asn 
    530                 535                 540                 


Glu Lys Lys Leu Asp Ile Glu Gln Lys Gln Asp Ile Tyr Leu Asn Leu 
545                 550                 555                 560 


Phe Thr Thr Ala Lys Asn Val Thr Lys Lys Ser Leu Ala Thr Tyr Leu 
                565                 570                 575     


Asn Cys Ser Ala Asp Ser Ile Ser Gly Leu Ser Asp Gly Glu Lys Phe 
            580                 585                 590         


Asn Ser Ser Leu Ser Ser Tyr Ile Asp Leu Lys Ala Ile Leu Gly Asn 
        595                 600                 605             


Ile Val Asp Asp Cys Asn Lys Asn Glu Asp Leu Glu Lys Ile Ile Glu 
    610                 615                 620                 


Tyr Ser Thr Val Phe Glu Asp Gly Asn Ile Tyr Lys Glu Lys Leu Ser 
625                 630                 635                 640 


Glu Ile Ser Trp Leu Thr Asp Glu Gln Ile Glu Lys Leu Ser Asn Ile 
                645                 650                 655     


His Phe Lys Gly Trp Gly Arg Leu Ser Lys Lys Leu Leu Thr Gln Ile 
            660                 665                 670         


Thr Asn Glu Asn Gly Glu Arg Ile Ile Asp Ala Leu Trp Asn Thr Ser 
        675                 680                 685             


Asn Asn Phe Met Gln Ile Ile Asn Asp Glu Ser Ile Gln Ala Lys Leu 
    690                 695                 700                 


Ala Glu Ile Asn Gly Lys Tyr Ala Gly Lys Ser Asp Leu Glu Asp Ile 
705                 710                 715                 720 


Leu Ser Glu Ala Tyr Thr Ser Pro Gln Asn Lys Lys Ala Ile Arg Gln 
                725                 730                 735     


Val Met Lys Val Val Glu Asp Ile Glu Lys Ala Met Gln Cys Glu Pro 
            740                 745                 750         


Thr Ser Ile Ser Ile Glu Phe Thr Arg Lys Lys Gln Lys Ser Arg Leu 
        755                 760                 765             


Thr Asn Thr Arg Tyr Lys Lys Ile Ser Asp Val Tyr Glu Lys Ile Ala 
    770                 775                 780                 


Asp Glu Val Ile Ser Glu Tyr Glu Leu Arg Lys Leu Gln Ser Glu Leu 
785                 790                 795                 800 


Asp Ser Asn Ala Asn Asn Met Arg Asp Arg Tyr Tyr Leu Tyr Phe Met 
                805                 810                 815     


Gln Leu Gly Arg Asp Met Tyr Thr Gly Glu Lys Ile Asn Ile Asp Glu 
            820                 825                 830         


Leu His Gln Arg Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Phe Ile 
        835                 840                 845             


Lys Asp Asp Ser Ile Asn Asn Arg Val Leu Thr Arg Lys Asp Val Asn 
    850                 855                 860                 


Asn Lys Glu Lys Ser Asp Lys Thr Ala Ala Asp Leu Tyr Ala Val Glu 
865                 870                 875                 880 


Met Ser Asp Phe Trp Arg Lys Leu Arg Lys Gln Gly Leu Ile Thr Glu 
                885                 890                 895     


Gln Lys Tyr Lys Asn Leu Leu Thr Lys Ser Asp Ser Ile Asp Lys Tyr 
            900                 905                 910         


Ala Lys Lys Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Ser Gln Val 
        915                 920                 925             


Val Lys Leu Val Ala Asn Ile Leu Gln Asp Lys Tyr Ser Asp Thr Lys 
    930                 935                 940                 


Ile Ile Glu Val Arg Ala Lys Leu Asn Ser Asn Leu Arg Glu Glu Tyr 
945                 950                 955                 960 


Lys Leu Ile Lys Asn Arg Ala Val Asn Asp Tyr His His Ala Ile Asp 
                965                 970                 975     


Gly Tyr Leu Thr Thr Phe Ile Gly Gln Tyr Leu Tyr Lys Thr Tyr Pro 
            980                 985                 990         


Lys Leu Arg Ser Tyr Phe Val Tyr  Asn Asp Phe Lys Lys  Leu Asp Ser 
        995                 1000                 1005             


Asn Tyr  Leu Lys His Met Lys  Lys Phe Asn Phe Leu  Trp Gln Leu 
    1010                 1015                 1020             


Gln Asp  Asp Lys Thr Ile Asp  Ile Tyr Asp Asn Val  Asn Asn Lys 
    1025                 1030                 1035             


Phe Val  Leu Asn Val Pro Glu  Met Lys Lys Tyr Ile  Gln Lys Ile 
    1040                 1045                 1050             


Tyr Asn  Tyr Lys Tyr Met Leu  Val Ser Lys Glu Val  Thr Thr Lys 
    1055                 1060                 1065             


Asn Gly  Ala Phe Tyr Asp Gln  Thr Lys Tyr Asn Ala  Lys Thr Val 
    1070                 1075                 1080             


Asn Leu  Ile Pro Ile Lys Lys  Asn Lys Pro Thr Asn  Ile Tyr Gly 
    1085                 1090                 1095             


Gly Tyr  Lys Gly Lys Val Ser  Ser Tyr Met Met Leu  Val Lys Ile 
    1100                 1105                 1110             


Arg Lys  Lys Lys Glu Val Ile  Tyr Lys Phe Val Gly  Val Pro Arg 
    1115                 1120                 1125             


Leu Trp  Thr Asp Glu Leu Asp  Arg Leu Lys Asp Thr  Thr Glu Arg 
    1130                 1135                 1140             


Lys Ile  Leu Leu Asn Glu Ile  Ala Lys Asn Ser Leu  Ser Lys Thr 
    1145                 1150                 1155             


Glu Gln  Asp Phe Glu Val Ile  Leu Asp Lys Val Tyr  Tyr Gly Gln 
    1160                 1165                 1170             


Leu Ile  Ile Asp Gly Asn Gln  Lys Tyr Thr Leu Gly  Ser Ser Glu 
    1175                 1180                 1185             


Tyr Lys  Tyr Asn Ala Met Gln  Leu His Leu Ser Lys  His Ala Leu 
    1190                 1195                 1200             


Glu Val  Leu Ala Lys Glu Asn  Val Lys Asp Ala Glu  Ile Thr Asp 
    1205                 1210                 1215             


Lys Asp  Leu Val Ser Val Tyr  Glu Glu Ile Leu Ser  Val Val Asn 
    1220                 1225                 1230             


Lys Tyr  Phe Glu Leu Tyr Asp  Ile Asn Lys Phe Arg  Gln Lys Leu 
    1235                 1240                 1245             


Asn Glu  Gly Leu Glu Ile Phe  Arg Lys Leu Pro Val  Tyr Asn Val 
    1250                 1255                 1260             


Tyr Glu  Ser Asn Lys Ile Lys  Gln Val Gly Lys Phe  Glu Val Leu 
    1265                 1270                 1275             


Asn Arg  Ile Leu Met Gly Leu  His Ala Asn Ala Met  Ile Thr Asp 
    1280                 1285                 1290             


Leu Lys  Val Leu Gly Ile Lys  Thr Lys Leu Gly Gln  Met Gln Val 
    1295                 1300                 1305             


Asn Gly  Gly Ile Lys Leu Ser  Pro Asp Ala Lys Leu  Ile Tyr Gln 
    1310                 1315                 1320             


Ser Pro  Thr Gly Ile Phe Ser  Arg Ala Val Arg Val  Lys Asp Leu 
    1325                 1330                 1335             


Gly 
    


<210> 300
<211> 1331
<212> PRT
<213> Lactobacillus sanfranciscensis

<400> 300
Met Asn Lys Gln Pro Tyr Asn Ile Gly Leu Asp Ile Gly Thr Ser Ser 
1               5                   10                  15      


Val Gly Trp Ser Ala Thr Glu Leu Asp Asn Arg Leu Leu His Ile Lys 
            20                  25                  30          


Gly His Asn Gly Ile Gly Val Arg Leu Phe Lys Glu Gly Glu Ser Ala 
        35                  40                  45              


Ala Asp Arg Arg Gly Phe Arg Thr Thr Arg Arg Arg Leu Ala Arg Arg 
    50                  55                  60                  


Lys Trp Arg Leu Arg Leu Leu Asn Glu Ile Phe Ala Thr Glu Ile Ala 
65                  70                  75                  80  


Lys Val Asp Pro Ser Phe Phe Ala Arg Leu Lys Gln Ser Asn Val Ser 
                85                  90                  95      


Pro Lys Asp Pro Asn Lys Thr Met Phe Glu Asn Ile Leu Phe Asp Asp 
            100                 105                 110         


Glu Asn Leu Asp Asp Gln Lys Phe His His Asp Tyr Lys Thr Ile Tyr 
        115                 120                 125             


His Leu Arg Gln Ala Ile Ile Asn His Pro Glu Gln Lys Phe Asp Ile 
    130                 135                 140                 


Arg Leu Ile Tyr Leu Ala Met His His Ile Ile Lys Tyr Arg Gly His 
145                 150                 155                 160 


Phe Leu Asn Gln Ala Asn Val Gln Asp Phe Lys Gly Gly Lys Ile Asp 
                165                 170                 175     


Leu Glu Lys Ser Phe Lys Ala Leu Asn Asp Ile Phe Glu Asn Gln Gly 
            180                 185                 190         


Arg Asp Leu Arg Leu Val Thr Asp Lys Ala Asn Gln Tyr Val Lys Val 
        195                 200                 205             


Leu Ser Asp Asn Ala Lys Thr Arg Ser Asp Arg Lys Lys Glu Leu Ser 
    210                 215                 220                 


Lys Leu Leu Tyr Val Pro Ile Asp Lys Asp Thr Asp Lys Asn Ser Lys 
225                 230                 235                 240 


Lys Val Thr Gly Glu Ile Leu Lys Ala Ile Leu Gly Asn Lys Ala Lys 
                245                 250                 255     


Phe Asp Val Ile Phe Gly Ile Glu Val Glu Asn Pro Lys Glu Trp Val 
            260                 265                 270         


Leu Thr Phe Asn Ser Asp Asp Phe Asp Asp Lys Ile Glu Gly Leu Ser 
        275                 280                 285             


Ser Gln Met Thr Asp Glu Asp Ser Glu Ile Leu Leu Ile Leu Lys Glu 
    290                 295                 300                 


Leu Tyr Phe Ala Leu Asn Leu Ser Asp Ile Leu Asn Asn Ser Val Thr 
305                 310                 315                 320 


Asp Lys Asn Ala Lys Thr Leu Ser Glu Ala Met Ile Asn Arg Tyr Asp 
                325                 330                 335     


Asp His Lys Asn Gln Leu Ala Met Leu Lys Lys Val Ile Asp Ser Ser 
            340                 345                 350         


Asp Lys Lys His Ala Lys Glu Leu Lys Glu Ala Tyr Ser Ala Tyr Ile 
        355                 360                 365             


Asp Gly Glu Asn Asn Lys Lys Ile Ser Phe Glu Asp Leu Lys Lys Arg 
    370                 375                 380                 


Ile Gln Lys Asn Leu Val Asp Ser Glu Leu Ser Gln Lys Ile Asn Asp 
385                 390                 395                 400 


Leu Leu Asp His Asp Tyr Phe Leu Pro Lys Gln Arg Ser Lys Glu Asn 
                405                 410                 415     


Gly Ala Ile Pro His Gln Leu Gln Gln Gln Glu Leu Asp Gln Ile Ile 
            420                 425                 430         


Glu Ser Gln Lys Gln Tyr Tyr Pro Phe Leu Ala Glu Leu Asn Pro Asn 
        435                 440                 445             


Glu Lys Arg Ser Arg Gln Ala Lys Tyr Lys Leu Asp Glu Leu Val Ala 
    450                 455                 460                 


Phe Arg Val Pro Tyr Tyr Val Gly Pro Met Val Glu Val Thr Asp Ser 
465                 470                 475                 480 


Asn Gln Glu Asn Asn Gly Lys Phe Ala Trp Met Ile Arg Lys Glu Gln 
                485                 490                 495     


Gly Glu Ile Thr Pro Trp Asn Phe Asp Glu Lys Val Asp Arg Thr Glu 
            500                 505                 510         


Thr Ala Thr Lys Phe Ile Thr Arg Met Thr Thr Thr Asp Thr Tyr Leu 
        515                 520                 525             


Ile Gly Glu Pro Val Leu Pro Lys Asn Ser Leu Leu Tyr Gln Lys Phe 
    530                 535                 540                 


Val Val Leu Asn Glu Leu Asn Asn Leu Lys Ile Asn Gln Glu Ile Ile 
545                 550                 555                 560 


Thr Pro Gly Gln Lys Gln Tyr Leu Tyr Glu His Val Met Lys Lys Asn 
                565                 570                 575     


Lys Arg Val Thr Leu Lys Lys Ile Ala Asp Ala Leu Val Ile Lys Gly 
            580                 585                 590         


Asp Tyr Pro Tyr Ala Pro Glu Val Lys Gly Thr Thr Asp Gln Lys Asn 
        595                 600                 605             


Leu Asn Asn Gly Leu Thr Thr Tyr Ile Asp Leu Ala Lys Ile Phe Gly 
    610                 615                 620                 


Asn Glu Leu Asp Asp Val Asp Arg Glu Ala Asp Phe Glu Lys Ile Ile 
625                 630                 635                 640 


Glu Trp Ser Thr Ile Phe Glu Asp Gln His Ile Phe Ala Leu Lys Leu 
                645                 650                 655     


Gln Glu Leu Lys Trp Leu Thr Glu Lys Gln Arg Asn Gln Val Val Lys 
            660                 665                 670         


Leu Arg Tyr Gln Gly Trp Gly Lys Leu Ser Lys Glu Leu Leu Ala Gly 
        675                 680                 685             


Leu Val Asp Asp Asn Gly Gln Arg Ile Ile Asp Leu Leu Trp Ser Asp 
    690                 695                 700                 


Asn Gln Asn Phe Met Gln Ile Val Asn Gln Lys Ser Phe Lys Glu Ser 
705                 710                 715                 720 


Ile Ala Asp His Asn Gly Ala His Leu Glu Glu Lys Asn Leu Lys Asp 
                725                 730                 735     


Val Ile Asn Asp Leu Tyr Thr Ser Pro Gln Asn Lys Lys Ala Ile Arg 
            740                 745                 750         


Gln Val Ile Leu Val Val Asp Asp Ile Ile Asn Ala Val Gly Tyr Glu 
        755                 760                 765             


Pro Ala Asn Ile Met Met Glu Phe Ala Arg Glu Asp Ser Asn Asp His 
    770                 775                 780                 


Arg Leu Thr Asn Ser Arg Ser Arg Gln Leu Glu Asn Val Tyr Lys Asp 
785                 790                 795                 800 


Ile Thr Asn Ser Trp Phe Asp Asn Asp Ser Val Lys Asp Glu Leu Glu 
                805                 810                 815     


Asp Lys Ile Lys Asn Lys Asp Lys Phe Thr Asp Arg Leu Tyr Leu Tyr 
            820                 825                 830         


Phe Thr Gln Gly Gly Lys Asp Leu Tyr Thr Gly Glu Pro Leu Asn Ile 
        835                 840                 845             


Asp Asp Leu Ser Ser Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Phe 
    850                 855                 860                 


Ile Leu Asp Asn Ser Leu Asp Asn Arg Val Leu Thr Ser Gln Arg Asn 
865                 870                 875                 880 


Asn Arg Val Ser Lys Glu Asp Gln Leu Pro Gly Glu Leu Phe Gly Thr 
                885                 890                 895     


Lys Met His Ala Phe Trp Lys Arg Leu Lys Ala Ala His Leu Ile Ser 
            900                 905                 910         


Asn Lys Lys Tyr Tyr Asn Leu Thr Leu Thr Pro Asn Ser Ile Ser Lys 
        915                 920                 925             


Phe Asn Asn Gln Gly Arg Phe Ile Asn Arg Gln Leu Val Glu Thr Arg 
    930                 935                 940                 


Gln Val Ile Lys Leu Ala Ala Glu Ile Leu His Asn Arg Tyr Ser Glu 
945                 950                 955                 960 


Glu Lys Gly Thr Asn Ile Val Thr Ile Lys Ala Asn Leu Thr His His 
                965                 970                 975     


Met Arg Glu Lys Phe Asn Phe Tyr Lys Asn Arg Asn Val Asn Asp Tyr 
            980                 985                 990         


His His Ala Phe Asp Ala Tyr Leu  Thr Ala Phe Val Gly  Asn Trp Leu 
        995                 1000                 1005             


Leu Gln  Gln Tyr Pro Lys Leu  Lys Pro Tyr Phe Val  Tyr Gly Asp 
    1010                 1015                 1020             


Phe Ala  Lys Thr Glu Ile Asn  Asn Leu Lys Ser Phe  Asn Met Leu 
    1025                 1030                 1035             


Tyr Lys  Phe Glu Gln Ala His  Gln Leu Asn Glu Lys  Asp Gly Lys 
    1040                 1045                 1050             


Ile Ala  Lys Asp Ala Asp Ala  Leu Leu Gly Tyr Met  Lys Asn Val 
    1055                 1060                 1065             


Tyr His  Phe Lys Lys Met Leu  Val Thr Lys Lys Leu  Glu Thr Asn 
    1070                 1075                 1080             


His Gly  Ala Leu Phe Lys Gln  Thr Leu Tyr Pro Ser  Pro Ala His 
    1085                 1090                 1095             


Asp Ile  Lys Lys Arg Gln Leu  Ile Lys Pro Lys Asp  Asn Arg Pro 
    1100                 1105                 1110             


Thr Asp  Ile Tyr Gly Gly Tyr  Thr His Glu Glu Arg  Lys Tyr Met 
    1115                 1120                 1125             


Ser Leu  Val Lys Val Ile Gly  Lys Lys Asp Asn Glu  Tyr Arg Met 
    1130                 1135                 1140             


Ala Asn  Val Pro Leu Leu Lys  Ile Asn Lys Asn Asn  Asp Ile Lys 
    1145                 1150                 1155             


Glu Ile  Leu Lys Ser Gln Phe  Ser Asn Lys Lys Phe  Glu Ile Val 
    1160                 1165                 1170             


Leu Pro  Lys Val Leu Lys Asn  Gln Leu Phe Ser Glu  Asn Gly Ala 
    1175                 1180                 1185             


Leu Phe  Val Ile Gly Ser Lys  Gly Tyr Lys Tyr Asn  Ala Asn Gln 
    1190                 1195                 1200             


Leu Val  Leu Ser Asp Leu Asp  Met Lys Leu Leu Asn  Asp Leu Ser 
    1205                 1210                 1215             


Asn Asn  Lys Ser Ile Asp Glu  Val Thr Ile Asn Gln  Leu Phe Lys 
    1220                 1225                 1230             


Asn Ile  Val Asp Ser Thr Asn  Lys Tyr Met Pro Leu  Tyr Glu Ile 
    1235                 1240                 1245             


Lys Asn  Leu Asn Glu Val Val  Glu Lys Phe Asn Asn  Leu Glu Phe 
    1250                 1255                 1260             


Asn Asp  Lys Lys Lys Thr Ile  Thr Asp Phe Leu Leu  Ala Thr His 
    1265                 1270                 1275             


Ala Asn  Pro Thr Met Ser Asn  Leu Lys Asn Ile Gly  Leu Pro Ser 
    1280                 1285                 1290             


Tyr Phe  Gly Arg Phe Thr Ser  Gly Asn Ala Gly Ile  Lys Leu Ser 
    1295                 1300                 1305             


Glu Asn  Ala Asn Val Ile Tyr  Gln Ser Pro Thr Gly  Leu Phe Ser 
    1310                 1315                 1320             


Arg Lys  Val Lys Ile Ser Asp  Phe 
    1325                 1330     


<210> 301
<211> 1419
<212> PRT
<213> Lactobacillus sp.


<220>
<223> Lactobacillus sp. 66c

<400> 301
Met Ala Lys Pro Gln Asn Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn 
1               5                   10                  15      


Ser Val Gly Trp Thr Val Thr Asp Asp Gln Asn Asn Ile Leu Arg Ile 
            20                  25                  30          


Lys Ser Lys Lys Ala Ile Gly Ala Arg Leu Phe Glu Glu Gly Lys Val 
        35                  40                  45              


Ala Ala Glu Arg Arg Ser Phe Arg Thr Thr Arg Arg Arg Leu Ser Arg 
    50                  55                  60                  


Arg Lys Trp Arg Ile Lys Leu Leu Glu Glu Leu Phe Asp Glu Glu Ile 
65                  70                  75                  80  


Ser Lys Val Asp Pro Asn Phe Phe Ala Arg Ser His Glu Ser Trp Ile 
                85                  90                  95      


Ser Pro Lys Asp Lys Arg Glu Arg Tyr Ser Ala Ile Val Phe Pro Thr 
            100                 105                 110         


Pro Glu Glu Asp Lys Lys Phe His Asn Glu Tyr Pro Thr Ile Tyr His 
        115                 120                 125             


Leu Arg Asp Arg Leu Met Lys Asp Asp Gln Lys His Asp Ile Arg Glu 
    130                 135                 140                 


Ile Tyr Val Ala Ile His His Ile Met Lys Tyr Arg Gly Asn Phe Leu 
145                 150                 155                 160 


His Asp Glu Ser Ile Glu Thr Tyr Arg Ser Gly Met Ser Ser Leu Gly 
                165                 170                 175     


Gly Gly Asp Glu Arg Thr Ile Leu Asn Thr Lys Ile Leu Asp Asp Leu 
            180                 185                 190         


Asn Asp Ala Phe Ala Asp Asn Leu Ala Thr Gln Gly Ile Ser Val Asn 
        195                 200                 205             


Ser Ala Ser Ala Asp Gln Ile Asn Glu Ile Val Thr Ser Gly His Leu 
    210                 215                 220                 


Asn Val Asp Ser Gln Lys Ala Ile Ala Lys Leu Leu Leu Pro Thr Thr 
225                 230                 235                 240 


Leu Ser Ser Asp Asp Lys Lys Gln Asp Lys Lys Ile Lys Lys Leu Ala 
                245                 250                 255     


Thr Asp Ala Ala Lys Asn Val Ala Ser Ala Trp Leu Gly Tyr Lys Ala 
            260                 265                 270         


Asn Phe Ala Ala Ile Leu Asn Ile Gln Glu Val Asp Lys Asp Lys Lys 
        275                 280                 285             


Lys Ile Tyr Ser Phe Ala Leu Gln Gly Ala Asp Glu Glu Asp Lys Val 
    290                 295                 300                 


Glu Thr Leu Glu Ser Val Leu Ser Gln Asp Gln Ile Glu Ile Val Asp 
305                 310                 315                 320 


Arg Ile Ile Arg Ile Arg His Ala Ile Val Leu Gly Glu Ile Ile Pro 
                325                 330                 335     


Val Gly Met Thr Leu Ser Glu Ala Met Ile Glu Lys Tyr Asp Gln His 
            340                 345                 350         


Ala Lys Asp Leu Lys Asn Leu Lys Thr Val Ile Arg Asn Leu Lys Asp 
        355                 360                 365             


Arg Lys Asn Ala Val Lys Leu Gln Ala Ile Tyr Asp Leu Tyr Val Asn 
    370                 375                 380                 


Asn Arg His Ala Asp Thr Ala Lys Ala Met Lys Leu Ala Gly Val Lys 
385                 390                 395                 400 


Lys Arg Thr Glu Leu Leu Glu Pro Glu Glu Phe Asn Lys Ser Ile Glu 
                405                 410                 415     


Lys Leu Leu Asp Asp Ser Pro Val Ser Ala Glu Ile Lys Lys Arg Ile 
            420                 425                 430         


Ala Glu Lys Asp Phe Leu Pro Leu Gln Arg Ser Asn Ser Asn Gly Val 
        435                 440                 445             


Ile Pro Asn Gln Leu His Gln Ile Glu Leu Asp Glu Ile Ile Lys Lys 
    450                 455                 460                 


Gln Ser Lys Tyr Tyr Pro Phe Leu Gly Glu Thr Asn Glu His Ala Ser 
465                 470                 475                 480 


Ala Asp Val Ala Arg Lys Ala Pro Thr Lys Leu Asp Gln Leu Leu Thr 
                485                 490                 495     


Phe Arg Val Pro Tyr Tyr Val Gly Pro Leu Ile Thr Lys Glu Glu Gln 
            500                 505                 510         


Glu Glu Gln Asp Gly His Ser Phe Ala Trp Met Ile Arg Lys Asn Pro 
        515                 520                 525             


Lys Asp His Glu Lys Ile Thr Pro Trp Asn Phe Asp Glu Lys Val Asp 
    530                 535                 540                 


Arg Met Ala Ser Ala Thr Gln Phe Ile Lys Arg Met Thr Thr Lys Asp 
545                 550                 555                 560 


Thr Tyr Leu Leu Gly Glu Asp Val Leu Pro Ser Ser Ser Leu Lys Tyr 
                565                 570                 575     


Gln Leu Phe Thr Val Leu Asn Glu Leu Asn Asn Leu Arg Ile Asn His 
            580                 585                 590         


Lys Lys Leu Thr Arg Glu Glu Lys Glu Gln Val Ile Glu Asp Leu Phe 
        595                 600                 605             


Lys Lys Tyr Lys Thr Val Lys Ala Asp Lys Phe Lys Asn Tyr Trp Gln 
    610                 615                 620                 


Lys Gly His Ala Gly Leu Asp Val Lys Ile Gln Gly Met Ala Asp Pro 
625                 630                 635                 640 


Glu Lys Phe Asn Ser Thr Met Ser Thr Tyr Ile Asp Leu Gln Lys Ile 
                645                 650                 655     


Phe Gly Asp Gln Leu Asp Asp Ala Gln Arg Gln Asn Asp Phe Glu Lys 
            660                 665                 670         


Ile Ile Glu Tyr Ser Thr Ile Phe Glu Asp Arg Lys Ile Leu Gly Glu 
        675                 680                 685             


Lys Leu Arg Ala Asp Phe Val Trp Leu Ser Glu Asp Gln Ile Lys Arg 
    690                 695                 700                 


Leu Cys Arg Leu Arg Leu Gln Gly Trp Gly Arg Leu Ser Leu Lys Leu 
705                 710                 715                 720 


Leu Thr Arg Leu Thr Asp Ala Asp Gly Gln Asn Val Leu Glu Arg Leu 
                725                 730                 735     


Leu Asn Ser Asn Asp Asn Phe Met Gln Ile Val Lys Asp Pro Val Ile 
            740                 745                 750         


Lys Ala Lys Ile Glu Gln Lys Asn Gln Lys Leu Leu Arg Ala Asp Trp 
        755                 760                 765             


Ser Glu Asn Ala Thr Glu Ser Ile Leu Asp Glu Ala Tyr Thr Ser Pro 
    770                 775                 780                 


Gln Asn Lys Lys Ala Ile Arg Gln Val Met Arg Val Val His Asp Ile 
785                 790                 795                 800 


Val Lys Ala Cys Asp Gly Asn Leu Pro Ala Lys Phe Ala Ile Glu Phe 
                805                 810                 815     


Ala Arg Ser Gln Asp Asp Asp Pro Lys Arg Thr Val Ala Arg Ala Asp 
            820                 825                 830         


Arg Leu Gln Lys Ile Tyr Ala Gln Ile Ser Asp Glu Val Val Ser Gln 
        835                 840                 845             


Gly Val Lys Asp Gln Leu Ser Gly Met Lys Ser Leu Lys Asp Arg Tyr 
    850                 855                 860                 


Tyr Leu Tyr Phe Met Gln Gly Gly Arg Asp Ala Tyr Thr Gly Lys Pro 
865                 870                 875                 880 


Leu Asn Ile Asp Arg Leu Ser Asp Tyr Asp Ile Asp His Ile Met Pro 
                885                 890                 895     


Gln Ser Phe Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Val Thr 
            900                 905                 910         


Arg Ala Val Asn Asn Gln Lys Ser Asp Asn Val Pro Val Leu Leu Tyr 
        915                 920                 925             


Gly Asn His Leu Val Ala Asp Leu Gly Ile Thr Ile Arg Glu Met Trp 
    930                 935                 940                 


Asp Arg Trp Gln Lys Ser Gly Met Ile Ser Lys Arg Lys Leu Ala Asn 
945                 950                 955                 960 


Leu Leu Thr Asp Pro Ala Thr Leu Ser Glu Tyr Arg Ala Glu Gly Phe 
                965                 970                 975     


Ile Asn Arg Gln Leu Val Glu Thr Ser Gln Val Ile Lys Leu Thr Ala 
            980                 985                 990         


Thr Ile Leu Gln Ser Glu Phe Pro  Asp Ser Lys Ile Ile  Glu Val Pro 
        995                 1000                 1005             


Ala Lys  Tyr Asn Ser Ile Leu  Arg Lys Gln Phe Asp  Leu Tyr Lys 
    1010                 1015                 1020             


Ser Arg  Glu Val Asn Asp Tyr  His His Ala Ile Asp  Ala Tyr Leu 
    1025                 1030                 1035             


Ser Thr  Ile Val Gly Asn Tyr  Leu Tyr Gln Val Tyr  Pro Asn Leu 
    1040                 1045                 1050             


Arg Arg  Leu Phe Val Tyr Gly  Glu Phe Lys Lys Phe  Ser His Gly 
    1055                 1060                 1065             


Glu Glu  Glu Ser Ser His Gln  Ala Val Arg Arg Val  Lys Ser Met 
    1070                 1075                 1080             


Asn Phe  Leu Asp Asp Leu Leu  Arg Gly Lys His Gly  Asp Asp Ile 
    1085                 1090                 1095             


Tyr Cys  Arg Val Thr Gly Glu  Val Ile Phe Ser Arg  Lys Asp Ile 
    1100                 1105                 1110             


Ile Ser  Lys Leu Lys Gln Ala  Tyr Ser Phe Lys Gln  Met Leu Val 
    1115                 1120                 1125             


Thr Gln  Glu Val Phe Thr Lys  Lys Ser Ala Leu Phe  Asp Gln Thr 
    1130                 1135                 1140             


Val Tyr  Pro Ser Pro Ala Arg  Asp Ser Lys Thr Arg  Ser Gly Leu 
    1145                 1150                 1155             


Ile Pro  Arg Lys Gln Gly Met  Asp Thr Glu Ile Tyr  Gly Gly Tyr 
    1160                 1165                 1170             


Ser Gly  Asn Lys Asp Ala Tyr  Phe Val Leu Ala Gln  Val Val Lys 
    1175                 1180                 1185             


Ser Lys  Gly His Thr Leu Gln  Val Val Gly Val Pro  Ile Arg Ala 
    1190                 1195                 1200             


Leu Arg  Ala Leu Ala Asn Cys  Ser Asn Tyr Ser Glu  Gln Leu Leu 
    1205                 1210                 1215             


Lys Ile  Val Lys Ala Gln Val  Leu Phe Asn Lys Lys  Thr Gly Lys 
    1220                 1225                 1230             


Ala Lys  Lys Gly Ile Ser Asp  Val Arg Ile Leu Leu  Asp Lys Ile 
    1235                 1240                 1245             


Pro Tyr  Arg Gln Pro Val Leu  Asp Gly Ser Ala Phe  Tyr Met Leu 
    1250                 1255                 1260             


Gly Ser  Ser Thr Tyr Lys Tyr  Asn Leu Lys Gln Ile  Ser Leu Ser 
    1265                 1270                 1275             


Gln Gln  Ser Met Lys Tyr Ile  Leu Asp Tyr Ile Asp  Asp Pro Asn 
    1280                 1285                 1290             


Phe Asn  Lys His Glu Met Thr  Lys Ile Asp Gln Gln  Asn Glu Lys 
    1295                 1300                 1305             


Glu Cys  Leu Leu Ser Val Tyr  Asp Glu Ile Leu Asp  Lys Met Asp 
    1310                 1315                 1320             


Lys Tyr  Leu Ser Leu Tyr Asp  Ile Asn Gly Phe Arg  Lys Lys Leu 
    1325                 1330                 1335             


His Val  Gly Arg Asp Lys Phe  Ile Lys Leu Glu Val  Glu Lys Gln 
    1340                 1345                 1350             


Ala Glu  Ala Ile Lys Asn Val  Leu Arg Gly Phe His  Ala Asn Ser 
    1355                 1360                 1365             


Asp Met  Thr Lys Leu Ser Asp  Leu Gly Leu Ser Thr  Ser Leu Gly 
    1370                 1375                 1380             


Phe Met  Gln Ala Ser Asp Gly  Ile Lys Leu Ser Asp  Asn Ala Val 
    1385                 1390                 1395             


Phe Ile  Tyr Gln Ser Pro Thr  Gly Leu Phe Glu Arg  Arg Val Lys 
    1400                 1405                 1410             


Val Ser  Asp Leu Leu Lys 
    1415                 


<210> 302
<211> 1289
<212> PRT
<213> Lactobacillus versmoldensis


<220>
<223> Lactobacillus versmoldensis KCTC 3814

<400> 302
Met Arg Arg Arg Tyr Arg Arg Arg Arg Asn Arg Leu Asn Trp Leu Asp 
1               5                   10                  15      


Glu Leu Phe Ala Asp Glu Leu Ala Lys Ile Asp Pro Ser Phe Leu Leu 
            20                  25                  30          


Arg Met Lys Asn Ser Trp Val Ser Lys Lys Glu Ser Thr Arg Lys Arg 
        35                  40                  45              


Asp Pro Tyr Asn Leu Phe Ile Asp Glu Lys Tyr Asn Asp Val Asp Tyr 
    50                  55                  60                  


Phe Asn Gln Tyr Pro Thr Ile Phe His Leu Arg Lys Glu Leu Ile Thr 
65                  70                  75                  80  


Glu Asp Lys Lys Val Asp Ile Arg Leu Ile Tyr Leu Ala Ile His Asn 
                85                  90                  95      


Ile Ile Lys Tyr Arg Gly Asn Phe Thr Leu Glu Asn Gln Asn Phe Asp 
            100                 105                 110         


Ile Ser Gln Leu Ser Ser Asn Phe Ser Gln Gln Ile Ser Asp Phe Phe 
        115                 120                 125             


Ala Leu Phe Ser Asp Phe Gly Val Ile Met Pro Glu Asp Phe Asp Pro 
    130                 135                 140                 


Asp Lys Ile Ser Asp Ile Leu Leu Asn Pro Asn Leu Ser Pro Ser Gly 
145                 150                 155                 160 


Lys Val Ser Glu Ala Ile Ala Thr Ile Ser Pro Lys Thr Asn Val Lys 
                165                 170                 175     


Ala Lys Ile Lys Ile Ile Leu Leu Leu Leu Val Gly Asn Asn Gly Asp 
            180                 185                 190         


Leu Lys Lys Leu Phe Asp Leu Glu Thr Thr Glu Lys Ile Ala Val Lys 
        195                 200                 205             


Leu Ser Ser Arg His Ile Asp Ser Glu Leu Pro Ile Ile Leu Ser Glu 
    210                 215                 220                 


Leu Asn Glu Gln Gln Glu Asn Ile Ile Thr Ile Ala Asn Ser Ile Phe 
225                 230                 235                 240 


Gly Ser Ile Ile Leu Lys Asp Phe Leu Gly Asp Glu Thr Ser Ile Ser 
                245                 250                 255     


Ala Ala Lys Val Ile Ser Phe Glu Asp His Lys Gln Asp Leu Gln Lys 
            260                 265                 270         


Leu Lys Thr Met Trp Arg Glu Thr Ser Asn Lys Glu Ala Val Lys Ala 
        275                 280                 285             


Gly Lys Lys Ala Tyr Glu Asp Tyr Ile Gly His Glu Asp Ser Glu Thr 
    290                 295                 300                 


Phe Tyr Lys Lys Ile Lys Lys Phe Leu Glu Lys Ala Gln Pro Val Asp 
305                 310                 315                 320 


Leu Ala Asn Lys Ala Leu Ala Glu Ile Glu Leu Glu Asn Tyr Leu Pro 
                325                 330                 335     


Lys Gln Arg Asn Arg Asn Asn Thr Val Ile Pro Tyr Gln Leu Asn Glu 
            340                 345                 350         


Asn Glu Leu Ile Ala Ile Leu Asp His Gln Glu Lys Tyr Tyr Pro Phe 
        355                 360                 365             


Leu Lys Glu Asn Arg Asp Lys Ile Leu Ser Leu Leu Thr Phe Arg Ile 
    370                 375                 380                 


Pro Tyr Tyr Val Gly Pro Leu Gln Asp Ser Asn Asn Asn Arg Phe Ser 
385                 390                 395                 400 


Trp Met Thr Arg Lys Ala Ser Gly Ala Ile Arg Pro Trp Asn Phe Ser 
                405                 410                 415     


Glu Lys Val Asn Val Glu Gln Ser Ser Asn Asp Phe Ile Lys Arg Met 
            420                 425                 430         


Arg Ser Thr Asp Thr Tyr Leu Ile Gly Glu Pro Val Leu Pro Lys Lys 
        435                 440                 445             


Ser Leu Ile Tyr Gln Cys Tyr Glu Val Leu Ser Glu Leu Asn Asn Thr 
    450                 455                 460                 


Arg Val Lys Asp Gly Ser Ser Asn Pro Lys Arg Leu Asp Val Thr Ile 
465                 470                 475                 480 


Lys Gln Arg Ile Tyr Asn Glu Ile Phe Lys Asn Gln Lys Ser Val Ser 
                485                 490                 495     


Val Lys Val Leu Gln Asn Trp Leu Ile Lys Glu Ser Tyr Phe Lys Ser 
            500                 505                 510         


Pro Glu Ile Ser Gly Leu Ala Asp Lys Lys Lys Tyr Leu Ser Ser Leu 
        515                 520                 525             


Ser Thr Tyr Ile Asp Phe Lys Lys Ile Phe Gly Gln Arg Phe Val Asp 
    530                 535                 540                 


Asp Pro Val Asn Ser Pro Gln Leu Glu Glu Leu Ala Glu Trp Leu Thr 
545                 550                 555                 560 


Leu Phe Glu Asp Lys Lys Ile Leu Leu Ile Lys Leu Gln Asn Ser Lys 
                565                 570                 575     


Tyr Ser Tyr Asp Gln Ala Thr Ile Asn Lys Leu Ser Thr Met Arg Tyr 
            580                 585                 590         


Gln Gly Thr Gly Lys Leu Ser Lys Lys Leu Leu Val Asp Leu Lys Thr 
        595                 600                 605             


Thr Lys Lys Ser Ile Gly Lys Ser Gly Ala Glu Ser Leu Ser Ile Leu 
    610                 615                 620                 


Asp Leu Met Trp Ser Thr Lys Asp Asn Phe Met Gln Ile Ile His Asp 
625                 630                 635                 640 


Ala Asp Tyr Thr Phe Glu Gln Gln Ile Lys Glu Phe Asn Tyr Asp Thr 
                645                 650                 655     


Glu Asp Glu Leu Thr Pro Leu Glu Lys Val Ala Asn Leu His Gly Ser 
            660                 665                 670         


Pro Ala Leu Lys Arg Gly Leu Asn Gln Ser Ile Lys Val Val Ala Asp 
        675                 680                 685             


Ile Val Lys Phe Met Gly His Asp Pro Glu Lys Ile Phe Ile Glu Phe 
    690                 695                 700                 


Thr Arg Ser Asp Asp Phe Ser Lys Leu Thr Ile Ser Arg Tyr Arg Arg 
705                 710                 715                 720 


Ile Lys Lys Gln Tyr Leu Glu Ile Ala Lys Ala Ile Lys Lys Ile Pro 
                725                 730                 735     


Ala Glu Phe Lys Asp Ile Lys Glu Tyr Gln Thr Gln Leu Glu Glu Asn 
            740                 745                 750         


Lys Gly Lys Leu Ala Ser Glu Arg Leu Met Leu Tyr Phe Leu Gln Cys 
        755                 760                 765             


Gly His Ser Leu Tyr Ser Asn Lys Pro Ile Asp Leu Asn Met Ile Asn 
    770                 775                 780                 


Ser Ser Lys Tyr His Val Asp His Ile Leu Pro Gln Ser Tyr Ile Lys 
785                 790                 795                 800 


Asp Asp Ser Leu Glu Asn Lys Ala Leu Val Leu Ala Ser Glu Asn Glu 
                805                 810                 815     


Asn Lys Ile Asp Asn Met Leu Ile Ser His Asp Ile Ile Ala Thr Asn 
            820                 825                 830         


Leu Pro Arg Trp Gln Ala Leu Lys Asp Gln Asn Leu Met Gly Ser Lys 
        835                 840                 845             


Lys Phe Ala Asp Leu Thr Arg Thr Thr Val Thr Glu Asn Gln Lys Lys 
    850                 855                 860                 


Gly Phe Ile Gln Arg Gln Leu Val Gln Thr Ser Gln Ile Val Lys Asn 
865                 870                 875                 880 


Ile Thr Leu Ile Leu Asn Asp Leu Tyr Lys Asn Thr Ser Cys Ile Glu 
                885                 890                 895     


Thr Arg Ala Thr Leu Ser Ser Glu Phe Arg Lys Ala Phe Ser Asn Phe 
            900                 905                 910         


Asp Glu Thr Thr Tyr His Tyr Gln Phe Pro Glu Phe Val Lys Asn Arg 
        915                 920                 925             


Asp Val Asn Asp Phe His His Ala Gln Asp Ala Phe Leu Ala Cys Val 
    930                 935                 940                 


Ile Gly Glu Tyr Gln Leu Lys Lys Tyr Pro Lys Asp Asn Leu Arg Leu 
945                 950                 955                 960 


Val Tyr Asp Gln Tyr Ser Lys Phe Leu Asp Ser Leu Lys Lys Asp Thr 
                965                 970                 975     


Arg Lys Lys Asn Gly Arg Met Pro Arg Tyr Thr Gln Asn Gly Phe Ile 
            980                 985                 990         


Ile Gly Ser Met Phe Asn Gly Lys  Thr Tyr Val Asp Asp  Asn Gly Glu 
        995                 1000                 1005             


Ile Ile  Trp Asp Gln Lys Ile  Lys Glu Ser Ile Arg  Lys Thr Phe 
    1010                 1015                 1020             


Asn Tyr  His Gln Phe Asn Val  Val Arg Gln Thr Ile  Glu Gln His 
    1025                 1030                 1035             


Gly Lys  Leu Phe Asn Asp Thr  Ile Gln Pro His Ser  Asp Arg Tyr 
    1040                 1045                 1050             


Lys Leu  Ile Pro Leu Lys Thr  Asn Arg Asp Pro Ala  Ile Tyr Gly 
    1055                 1060                 1065             


Gly Tyr  Asn Asn Asp Asn Asn  Ala Tyr Ser Val Val  Leu Asp Val 
    1070                 1075                 1080             


Asp Gly  Lys Lys Lys Ile Asn  Gly Ile Pro Ile Arg  Ile Ala Asn 
    1085                 1090                 1095             


Gln Leu  Lys Ser Asp Glu Leu  Asp Leu Ser Ser Trp  Leu Glu Asn 
    1100                 1105                 1110             


Asn Ile  Lys His Lys Lys Pro  Met Thr Ile Leu Ile  Asp Lys Val 
    1115                 1120                 1125             


Pro Lys  Tyr Gln Arg Ile Ile  Asn Glu Glu Thr Gly  Asp Leu Leu 
    1130                 1135                 1140             


Ile Thr  Ser Ala Asn Glu Val  Ile Asn Asn Val Gln  Leu Phe Leu 
    1145                 1150                 1155             


Pro Ser  Met Tyr Thr Ala Leu  Ile Ser Leu Leu Asp  Ser Thr Lys 
    1160                 1165                 1170             


Thr Glu  Met Tyr Ser Lys Leu  Leu Ser Asn Tyr Glu  Ala Asn Ile 
    1175                 1180                 1185             


Leu Ile  Asp Ile Tyr Asp Tyr  Leu Leu Thr Lys Leu  Lys Asn Asn 
    1190                 1195                 1200             


Tyr Pro  Leu Tyr Arg Lys Glu  Trp Ala Lys Leu Ala  Glu His Arg 
    1205                 1210                 1215             


Asp Asp  Phe Ile Glu Ser Asp  Leu Val Thr Gln Ala  Ser Thr Leu 
    1220                 1225                 1230             


Gln Gln  Leu Ile Lys Phe Met  His Ala Asp Pro Ser  Asn Val Asn 
    1235                 1240                 1245             


Leu Lys  Phe Gly Asn Phe Lys  Gly Asn Arg Phe Gly  Arg Lys Asn 
    1250                 1255                 1260             


Gly Asn  Ile Lys Leu Ser Lys  Thr Asp Phe Ile Tyr  Glu Ser Pro 
    1265                 1270                 1275             


Thr Gly  Leu Phe Lys Ser Ile  Lys His Ile Asp 
    1280                 1285                 


<210> 303
<211> 1372
<212> PRT
<213> Legionella pneumophila


<220>
<223> Legionella pneumophila 130b

<400> 303
Met Glu Ser Ser Gln Ile Leu Ser Pro Ile Gly Ile Asp Leu Gly Gly 
1               5                   10                  15      


Lys Phe Thr Gly Val Cys Leu Ser His Leu Glu Ala Phe Ala Glu Leu 
            20                  25                  30          


Pro Asn His Ala Asn Thr Lys Tyr Ser Val Ile Leu Ile Asp His Asn 
        35                  40                  45              


Asn Phe Gln Leu Ser Gln Ala Gln Arg Arg Ala Thr Arg His Arg Val 
    50                  55                  60                  


Arg Asn Lys Lys Arg Asn Gln Phe Val Lys Arg Val Ala Leu Gln Leu 
65                  70                  75                  80  


Phe Gln His Ile Leu Ser Arg Asp Leu Asn Ala Lys Glu Glu Thr Ala 
                85                  90                  95      


Leu Cys His Tyr Leu Asn Asn Arg Gly Tyr Thr Tyr Val Asp Thr Asp 
            100                 105                 110         


Leu Asp Glu Tyr Ile Lys Asp Glu Thr Thr Ile Asn Leu Leu Lys Glu 
        115                 120                 125             


Leu Leu Pro Ser Glu Ser Glu His Asn Phe Ile Asp Trp Phe Leu Gln 
    130                 135                 140                 


Lys Met Gln Ser Ser Glu Phe Arg Lys Ile Leu Val Ser Lys Val Glu 
145                 150                 155                 160 


Glu Lys Lys Asp Asp Lys Glu Leu Lys Asn Ala Val Lys Asn Ile Lys 
                165                 170                 175     


Asn Phe Ile Thr Gly Phe Glu Lys Asn Ser Val Glu Gly His Arg His 
            180                 185                 190         


Arg Lys Val Tyr Phe Glu Asn Ile Lys Ser Asp Ile Thr Lys Asp Asn 
        195                 200                 205             


Gln Leu Asp Ser Ile Lys Lys Lys Ile Pro Ser Val Cys Leu Ser Asn 
    210                 215                 220                 


Leu Leu Gly His Leu Ser Asn Leu Gln Trp Lys Asn Leu His Arg Tyr 
225                 230                 235                 240 


Leu Ala Lys Asn Pro Lys Gln Phe Asp Glu Gln Thr Phe Gly Asn Glu 
                245                 250                 255     


Phe Leu Arg Met Leu Lys Asn Phe Arg His Leu Lys Gly Ser Gln Glu 
            260                 265                 270         


Ser Leu Ala Val Arg Asn Leu Ile Gln Gln Leu Glu Gln Ser Gln Asp 
        275                 280                 285             


Tyr Ile Ser Ile Leu Glu Lys Thr Pro Pro Glu Ile Thr Ile Pro Pro 
    290                 295                 300                 


Tyr Glu Ala Arg Thr Asn Thr Gly Met Glu Lys Asp Gln Ser Leu Leu 
305                 310                 315                 320 


Leu Asn Pro Glu Lys Leu Asn Asn Leu Tyr Pro Asn Trp Arg Asn Leu 
                325                 330                 335     


Ile Pro Gly Ile Ile Asp Ala His Pro Phe Leu Glu Lys Asp Leu Glu 
            340                 345                 350         


His Thr Lys Leu Arg Asp Arg Lys Arg Ile Ile Ser Pro Ser Lys Gln 
        355                 360                 365             


Asp Glu Lys Arg Asp Ser Tyr Ile Leu Gln Arg Tyr Leu Asp Leu Asn 
    370                 375                 380                 


Lys Lys Ile Asp Lys Phe Lys Ile Lys Lys Gln Leu Ser Phe Leu Gly 
385                 390                 395                 400 


Gln Gly Lys Gln Leu Pro Ala Asn Leu Ile Glu Thr Gln Lys Glu Met 
                405                 410                 415     


Glu Thr His Phe Asn Ser Ser Leu Val Ser Val Leu Ile Gln Ile Ala 
            420                 425                 430         


Ser Ala Tyr Asn Lys Glu Arg Glu Asp Ala Ala Gln Gly Ile Trp Phe 
        435                 440                 445             


Asp Asn Ala Phe Ser Leu Cys Glu Leu Ser Asn Ile Asn Pro Pro Arg 
    450                 455                 460                 


Lys Gln Lys Ile Leu Pro Leu Leu Val Gly Ala Ile Leu Ser Glu Asp 
465                 470                 475                 480 


Phe Ile Asn Asn Lys Asp Lys Trp Ala Lys Phe Lys Asn Phe Trp Asn 
                485                 490                 495     


Thr His Lys Ile Gly Arg Thr Ser Leu Lys Ser Lys Cys Lys Glu Ile 
            500                 505                 510         


Glu Glu Ala Arg Lys Asn Ser Gly Asn Ala Phe Lys Ile Asp Tyr Glu 
        515                 520                 525             


Glu Ala Leu Asn His Pro Glu His Ser Asn Asn Lys Ala Leu Ile Lys 
    530                 535                 540                 


Ile Ile Gln Thr Ile Pro Asp Ile Ile Gln Ala Ile Gln Ser His Leu 
545                 550                 555                 560 


Gly His Asn Asp Ser Gln Ala Leu Ile Tyr His Asn Pro Phe Ser Leu 
                565                 570                 575     


Ser Gln Leu Tyr Thr Ile Leu Glu Thr Lys Arg Asp Gly Phe His Lys 
            580                 585                 590         


Asn Cys Val Ala Val Thr Cys Glu Asn Tyr Trp Arg Ser Gln Lys Thr 
        595                 600                 605             


Glu Ile Asp Pro Glu Ile Ser Tyr Ala Ser Arg Leu Pro Ala Asp Ser 
    610                 615                 620                 


Val Arg Pro Phe Asp Gly Val Leu Ala Arg Met Met Gln Arg Leu Ala 
625                 630                 635                 640 


Tyr Glu Ile Ala Met Ala Lys Trp Glu Gln Ile Lys His Ile Pro Asp 
                645                 650                 655     


Asn Ser Ser Leu Leu Ile Pro Ile Tyr Leu Glu Gln Asn Arg Phe Glu 
            660                 665                 670         


Phe Glu Glu Ser Phe Lys Lys Ile Lys Gly Gly Ser Ser Asp Lys Thr 
        675                 680                 685             


Leu Glu Gln Ala Ile Glu Lys Gln Asn Ile Gln Trp Glu Glu Lys Phe 
    690                 695                 700                 


Gln Arg Ile Ile Asn Ala Ser Met Asn Ile Cys Pro Tyr Lys Gly Ala 
705                 710                 715                 720 


Ser Ile Gly Gly Gln Gly Glu Ile Asp His Ile Tyr Pro Arg Ser Leu 
                725                 730                 735     


Ser Lys Lys His Phe Gly Val Ile Phe Asn Ser Glu Ala Asn Leu Ile 
            740                 745                 750         


Tyr Cys Ser Ser Gln Gly Asn Arg Glu Lys Lys Glu Glu His Tyr Leu 
        755                 760                 765             


Leu Glu His Leu Ser Pro Leu Tyr Leu Lys His Gln Phe Gly Thr Asp 
    770                 775                 780                 


Asn Val Ser Asp Ile Lys Asn Phe Ile Ser Gln Asn Val Ala Asn Ile 
785                 790                 795                 800 


Lys Lys Tyr Ile Ser Phe His Leu Leu Thr Pro Glu Gln Gln Lys Ala 
                805                 810                 815     


Ala Arg His Ala Leu Phe Leu Asp Tyr Asp Asp Glu Ala Phe Lys Thr 
            820                 825                 830         


Ile Thr Lys Phe Leu Met Ser Gln Gln Lys Ala Arg Val Asn Gly Thr 
        835                 840                 845             


Gln Lys Phe Leu Gly Lys Gln Ile Met Glu Phe Leu Ser Thr Leu Ala 
    850                 855                 860                 


Asp Ser Lys Gln Leu Gln Leu Glu Phe Ser Ile Lys Gln Ile Thr Ala 
865                 870                 875                 880 


Glu Glu Val His Asp His Arg Glu Leu Leu Ser Lys Gln Glu Pro Lys 
                885                 890                 895     


Leu Val Lys Ser Arg Gln Gln Ser Phe Pro Ser His Ala Ile Asp Ala 
            900                 905                 910         


Thr Leu Thr Met Ser Ile Gly Leu Lys Glu Phe Pro Gln Phe Ser Gln 
        915                 920                 925             


Glu Leu Asp Asn Ser Trp Phe Ile Asn His Leu Met Pro Asp Glu Val 
    930                 935                 940                 


His Leu Asn Pro Val Arg Ser Lys Glu Lys Tyr Asn Lys Pro Asn Ile 
945                 950                 955                 960 


Ser Ser Thr Pro Leu Phe Lys Asp Ser Leu Tyr Ala Glu Arg Phe Ile 
                965                 970                 975     


Pro Val Trp Val Lys Gly Glu Thr Phe Ala Ile Gly Phe Ser Glu Lys 
            980                 985                 990         


Asp Leu Phe Glu Ile Lys Pro Ser  Asn Lys Glu Lys Leu  Phe Thr Leu 
        995                 1000                 1005             


Leu Lys  Thr Tyr Ser Thr Lys  Asn Pro Gly Glu Ser  Leu Gln Glu 
    1010                 1015                 1020             


Leu Gln  Ala Lys Ser Lys Ala  Lys Trp Leu Tyr Phe  Pro Ile Asn 
    1025                 1030                 1035             


Lys Thr  Leu Ala Leu Glu Phe  Leu His His Tyr Phe  His Lys Glu 
    1040                 1045                 1050             


Ile Val  Thr Pro Asp Asp Thr  Thr Val Cys His Phe  Ile Asn Ser 
    1055                 1060                 1065             


Leu Arg  Tyr Tyr Thr Lys Lys  Glu Ser Ile Thr Val  Lys Ile Leu 
    1070                 1075                 1080             


Lys Glu  Pro Met Pro Val Leu  Ser Val Lys Phe Glu  Ser Ser Lys 
    1085                 1090                 1095             


Lys Asn  Val Leu Gly Ser Phe  Lys His Thr Ile Ala  Leu Pro Ala 
    1100                 1105                 1110             


Thr Lys  Asp Trp Glu Arg Leu  Phe Asn His Pro Asn  Phe Leu Ala 
    1115                 1120                 1125             


Leu Lys  Ala Asn Pro Ala Pro  Asn Pro Lys Glu Phe  Asn Glu Phe 
    1130                 1135                 1140             


Ile Arg  Lys Tyr Phe Leu Ser  Asp Asn Asn Pro Asn  Ser Asp Ile 
    1145                 1150                 1155             


Pro Asn  Asn Gly His Asn Ile  Lys Pro Gln Lys His  Lys Ala Val 
    1160                 1165                 1170             


Arg Lys  Val Phe Ser Leu Pro  Val Ile Pro Gly Asn  Ala Gly Thr 
    1175                 1180                 1185             


Met Met  Arg Ile Arg Arg Lys  Asp Asn Lys Gly Gln  Pro Leu Tyr 
    1190                 1195                 1200             


Gln Leu  Gln Thr Ile Asp Asp  Thr Pro Ser Met Gly  Ile Gln Ile 
    1205                 1210                 1215             


Asn Glu  Asp Arg Leu Val Lys  Gln Glu Val Leu Met  Asp Ala Tyr 
    1220                 1225                 1230             


Lys Thr  Arg Asn Leu Ser Thr  Ile Asp Gly Ile Asn  Asn Ser Glu 
    1235                 1240                 1245             


Gly Gln  Ala Tyr Ala Thr Phe  Asp Asn Trp Leu Thr  Leu Pro Val 
    1250                 1255                 1260             


Ser Thr  Phe Lys Pro Glu Ile  Ile Lys Leu Glu Met  Lys Pro His 
    1265                 1270                 1275             


Ser Lys  Thr Arg Arg Tyr Ile  Arg Ile Thr Gln Ser  Leu Ala Asp 
    1280                 1285                 1290             


Phe Ile  Lys Thr Ile Asp Glu  Ala Leu Met Ile Lys  Pro Ser Asp 
    1295                 1300                 1305             


Ser Ile  Asp Asp Pro Leu Asn  Met Pro Asn Glu Ile  Val Cys Lys 
    1310                 1315                 1320             


Asn Lys  Leu Phe Gly Asn Glu  Leu Lys Pro Arg Asp  Gly Lys Met 
    1325                 1330                 1335             


Lys Ile  Val Ser Thr Gly Lys  Ile Val Thr Tyr Glu  Phe Glu Ser 
    1340                 1345                 1350             


Asp Ser  Thr Pro Gln Trp Ile  Gln Thr Leu Tyr Val  Thr Gln Leu 
    1355                 1360                 1365             


Lys Lys  Gln Pro 
    1370         


<210> 304
<211> 1372
<212> PRT
<213> Legionella pneumophila

<400> 304
Met Glu Ser Ser Gln Ile Leu Ser Pro Ile Gly Ile Asp Leu Gly Gly 
1               5                   10                  15      


Lys Phe Thr Gly Val Cys Leu Ser His Leu Glu Ala Phe Ala Glu Leu 
            20                  25                  30          


Pro Asn His Ala Asn Thr Lys Tyr Ser Val Ile Leu Ile Asp His Asn 
        35                  40                  45              


Asn Phe Gln Leu Ser Gln Ala Gln Arg Arg Ala Thr Arg His Arg Val 
    50                  55                  60                  


Arg Asn Lys Lys Arg Asn Gln Phe Val Lys Arg Val Ala Leu Gln Leu 
65                  70                  75                  80  


Phe Gln His Ile Leu Ser Arg Asp Leu Asn Ala Lys Glu Glu Thr Ala 
                85                  90                  95      


Leu Cys His Tyr Leu Asn Asn Arg Gly Tyr Thr Tyr Val Asp Thr Asp 
            100                 105                 110         


Leu Asp Glu Tyr Ile Lys Asp Glu Thr Thr Ile Asn Leu Leu Lys Glu 
        115                 120                 125             


Leu Leu Pro Ser Glu Ser Glu His Asn Phe Ile Asp Trp Phe Leu Gln 
    130                 135                 140                 


Lys Met Gln Ser Ser Glu Phe Arg Lys Ile Leu Val Ser Lys Val Glu 
145                 150                 155                 160 


Glu Lys Lys Asp Asp Lys Glu Leu Lys Asn Ala Val Lys Asn Ile Lys 
                165                 170                 175     


Asn Phe Ile Thr Gly Phe Glu Lys Asn Ser Val Glu Gly His Arg His 
            180                 185                 190         


Arg Lys Val Tyr Phe Glu Asn Ile Lys Ser Asp Ile Thr Lys Asp Asn 
        195                 200                 205             


Gln Leu Asp Ser Ile Lys Lys Lys Ile Pro Ser Val Cys Leu Ser Asn 
    210                 215                 220                 


Leu Leu Gly His Leu Ser Asn Leu Gln Trp Lys Asn Leu His Arg Tyr 
225                 230                 235                 240 


Leu Ala Lys Asn Pro Lys Gln Phe Asp Glu Gln Thr Phe Gly Asn Glu 
                245                 250                 255     


Phe Leu Arg Met Leu Lys Asn Phe Arg His Leu Lys Gly Ser Gln Glu 
            260                 265                 270         


Ser Leu Ala Val Arg Asn Leu Ile Gln Gln Leu Glu Gln Ser Gln Asp 
        275                 280                 285             


Tyr Ile Ser Ile Leu Glu Lys Thr Pro Pro Glu Ile Thr Ile Pro Pro 
    290                 295                 300                 


Tyr Glu Ala Arg Thr Asn Thr Gly Met Glu Lys Asp Gln Ser Leu Leu 
305                 310                 315                 320 


Leu Asn Pro Glu Lys Leu Asn Asn Leu Tyr Pro Asn Trp Arg Asn Leu 
                325                 330                 335     


Ile Pro Gly Ile Ile Asp Ala His Pro Phe Leu Glu Lys Asp Leu Glu 
            340                 345                 350         


His Thr Lys Leu Arg Asp Arg Lys Arg Ile Ile Ser Pro Ser Lys Gln 
        355                 360                 365             


Asp Glu Lys Arg Asp Ser Tyr Ile Leu Gln Arg Tyr Leu Asp Leu Asn 
    370                 375                 380                 


Lys Lys Ile Asp Lys Phe Lys Ile Lys Lys Gln Leu Ser Phe Leu Gly 
385                 390                 395                 400 


Gln Gly Lys Gln Leu Pro Ala Asn Leu Ile Glu Thr Gln Lys Glu Met 
                405                 410                 415     


Glu Thr His Phe Asn Ser Ser Leu Val Ser Val Leu Ile Gln Ile Ala 
            420                 425                 430         


Ser Ala Tyr Asn Lys Glu Arg Glu Asp Ala Ala Gln Gly Ile Trp Phe 
        435                 440                 445             


Asp Asn Ala Phe Ser Leu Cys Glu Leu Ser Asn Ile Asn Pro Pro Arg 
    450                 455                 460                 


Lys Gln Lys Ile Leu Pro Leu Leu Val Gly Ala Ile Leu Ser Glu Asp 
465                 470                 475                 480 


Phe Ile Asn Asn Lys Asp Lys Trp Ala Lys Phe Lys Ile Phe Trp Asn 
                485                 490                 495     


Thr His Lys Ile Gly Arg Thr Ser Leu Lys Ser Lys Cys Lys Glu Ile 
            500                 505                 510         


Glu Glu Ala Arg Lys Asn Ser Gly Asn Ala Phe Lys Ile Asp Tyr Glu 
        515                 520                 525             


Glu Ala Leu Asn His Pro Glu His Ser Asn Asn Lys Ala Leu Ile Lys 
    530                 535                 540                 


Ile Ile Gln Thr Ile Pro Asp Ile Ile Gln Ala Ile Gln Ser His Leu 
545                 550                 555                 560 


Gly His Asn Asp Ser Gln Ala Leu Ile Tyr His Asn Pro Phe Ser Leu 
                565                 570                 575     


Ser Gln Leu Tyr Thr Ile Leu Glu Thr Lys Arg Asp Gly Phe His Lys 
            580                 585                 590         


Asn Cys Val Ala Val Thr Cys Glu Asn Tyr Trp Arg Ser Gln Lys Thr 
        595                 600                 605             


Glu Ile Asp Pro Glu Ile Ser Tyr Ala Ser Arg Leu Pro Ala Asp Ser 
    610                 615                 620                 


Val Arg Pro Phe Asp Gly Val Leu Ala Arg Met Met Gln Arg Leu Ala 
625                 630                 635                 640 


Tyr Glu Ile Ala Met Ala Lys Trp Glu Gln Ile Lys His Ile Pro Asp 
                645                 650                 655     


Asn Ser Ser Leu Leu Ile Pro Ile Tyr Leu Glu Gln Asn Arg Phe Glu 
            660                 665                 670         


Phe Glu Glu Ser Phe Lys Lys Ile Lys Gly Ser Ser Ser Asp Lys Thr 
        675                 680                 685             


Leu Glu Gln Ala Ile Glu Lys Gln Asn Ile Gln Trp Glu Glu Lys Phe 
    690                 695                 700                 


Gln Arg Ile Ile Asn Ala Ser Met Asn Ile Cys Pro Tyr Lys Gly Ala 
705                 710                 715                 720 


Ser Ile Gly Gly Gln Gly Glu Ile Asp His Ile Tyr Pro Arg Ser Leu 
                725                 730                 735     


Ser Lys Lys His Phe Gly Val Ile Phe Asn Ser Glu Val Asn Leu Ile 
            740                 745                 750         


Tyr Cys Ser Ser Gln Gly Asn Arg Glu Lys Lys Glu Glu His Tyr Leu 
        755                 760                 765             


Leu Glu His Leu Ser Pro Leu Tyr Leu Lys His Gln Phe Gly Thr Asp 
    770                 775                 780                 


Asn Val Ser Asp Ile Lys Asn Phe Ile Ser Gln Asn Val Ala Asn Ile 
785                 790                 795                 800 


Lys Lys Tyr Ile Ser Phe His Leu Leu Thr Pro Glu Gln Gln Lys Ala 
                805                 810                 815     


Ala Arg His Ala Leu Phe Leu Asp Tyr Asp Asp Glu Ala Phe Lys Thr 
            820                 825                 830         


Ile Thr Lys Phe Leu Met Ser Gln Gln Lys Ala Arg Val Asn Gly Thr 
        835                 840                 845             


Gln Lys Phe Leu Gly Lys Gln Ile Met Glu Phe Leu Ser Thr Leu Ala 
    850                 855                 860                 


Asp Ser Lys Gln Leu Gln Leu Glu Phe Ser Ile Lys Gln Ile Thr Ala 
865                 870                 875                 880 


Glu Glu Val His Asp His Arg Glu Leu Leu Ser Lys Gln Glu Pro Lys 
                885                 890                 895     


Leu Val Lys Ser Arg Gln Gln Ser Phe Pro Ser His Ala Ile Asp Ala 
            900                 905                 910         


Thr Leu Thr Met Ser Ile Gly Leu Lys Glu Phe Pro Gln Phe Ser Gln 
        915                 920                 925             


Glu Leu Asp Asn Ser Trp Phe Ile Asn His Leu Met Pro Asp Glu Val 
    930                 935                 940                 


His Leu Asn Pro Val Arg Ser Lys Glu Lys Tyr Asn Lys Pro Asn Ile 
945                 950                 955                 960 


Ser Ser Thr Pro Leu Phe Lys Asp Ser Leu Tyr Ala Glu Arg Phe Ile 
                965                 970                 975     


Pro Val Trp Val Lys Gly Glu Thr Phe Ala Ile Gly Phe Ser Glu Lys 
            980                 985                 990         


Asp Leu Phe Glu Ile Lys Pro Ser  Asn Lys Glu Lys Leu  Phe Thr Leu 
        995                 1000                 1005             


Leu Lys  Thr Tyr Ser Thr Lys  Asn Pro Gly Glu Ser  Leu Gln Glu 
    1010                 1015                 1020             


Leu Gln  Ala Lys Ser Lys Ala  Lys Trp Leu Tyr Phe  Pro Ile Asn 
    1025                 1030                 1035             


Lys Thr  Leu Ala Leu Glu Phe  Leu His His Tyr Phe  His Lys Glu 
    1040                 1045                 1050             


Ile Val  Thr Pro Asp Asp Thr  Thr Val Cys His Phe  Ile Asn Ser 
    1055                 1060                 1065             


Leu Arg  Tyr Tyr Thr Lys Lys  Glu Ser Ile Thr Val  Lys Ile Leu 
    1070                 1075                 1080             


Lys Glu  Pro Met Pro Val Leu  Ser Val Lys Phe Glu  Ser Ser Lys 
    1085                 1090                 1095             


Lys Asn  Val Leu Gly Ser Phe  Lys His Thr Ile Ala  Leu Pro Ala 
    1100                 1105                 1110             


Thr Lys  Asp Trp Glu Arg Leu  Phe Asn His Pro Asn  Phe Leu Ala 
    1115                 1120                 1125             


Leu Lys  Ala Asn Pro Ala Pro  Asn Pro Lys Glu Phe  Asn Glu Phe 
    1130                 1135                 1140             


Ile Arg  Lys Tyr Phe Leu Ser  Asp Asn Asn Pro Asn  Ser Asp Ile 
    1145                 1150                 1155             


Pro Asn  Asn Gly His Asn Ile  Lys Pro Gln Lys His  Lys Ala Val 
    1160                 1165                 1170             


Arg Lys  Val Phe Ser Leu Pro  Val Ile Pro Gly Asn  Ala Gly Thr 
    1175                 1180                 1185             


Met Met  Arg Ile Arg Arg Lys  Asp Asn Lys Gly Gln  Pro Leu Tyr 
    1190                 1195                 1200             


Gln Leu  Gln Thr Ile Asp Asp  Thr Pro Ser Met Gly  Ile Gln Ile 
    1205                 1210                 1215             


Asn Glu  Asp Arg Leu Val Lys  Gln Glu Val Leu Met  Asp Ala Tyr 
    1220                 1225                 1230             


Lys Thr  Arg Asn Leu Ser Thr  Ile Asp Gly Ile Asn  Asn Ser Glu 
    1235                 1240                 1245             


Gly Gln  Ala Tyr Ala Thr Phe  Asp Asn Trp Leu Thr  Leu Pro Val 
    1250                 1255                 1260             


Ser Thr  Phe Lys Pro Glu Ile  Ile Lys Leu Glu Met  Lys Pro His 
    1265                 1270                 1275             


Ser Lys  Thr Arg Arg Tyr Ile  Arg Ile Thr Gln Ser  Leu Ala Asp 
    1280                 1285                 1290             


Phe Ile  Lys Thr Ile Asp Glu  Ala Leu Met Ile Lys  Pro Ser Asp 
    1295                 1300                 1305             


Ser Ile  Asp Asp Pro Leu Asn  Met Pro Asn Glu Ile  Val Cys Lys 
    1310                 1315                 1320             


Asn Lys  Leu Phe Gly Asn Glu  Leu Lys Pro Arg Asp  Gly Lys Met 
    1325                 1330                 1335             


Lys Ile  Val Ser Thr Gly Lys  Ile Val Thr Tyr Glu  Phe Glu Ser 
    1340                 1345                 1350             


Asp Ser  Thr Pro Gln Trp Ile  Gln Thr Leu Tyr Val  Thr Gln Leu 
    1355                 1360                 1365             


Lys Lys  Gln Pro 
    1370         


<210> 305
<211> 1355
<212> PRT
<213> Leuconostoc gelidum


<220>
<223> Leuconostoc gelidum KCTC 3527

<400> 305
Met Thr Tyr Ser Ile Gly Leu Asp Ile Gly Thr Gly Ser Val Gly Trp 
1               5                   10                  15      


Ala Val Ile Gly Asp Asp Tyr Arg Leu Lys Arg Ala Lys Gly Lys Asn 
            20                  25                  30          


Leu Ile Gly Val Arg Leu Phe Asp Ser Ala Thr Thr Ala Ala Glu Arg 
        35                  40                  45              


Arg Gly Tyr Arg Thr Thr Arg Arg Arg Leu Ser Arg Arg His Trp Arg 
    50                  55                  60                  


Leu Arg Leu Leu Asn Asp Ile Phe Ala Ser Asp Leu Ala Glu Gln Asp 
65                  70                  75                  80  


Glu Asn Phe Leu Pro Arg Leu Lys Tyr Ser Trp Val Asn Pro Asp Asp 
                85                  90                  95      


Glu Gln Asn Pro Gln Leu Asn Ser Asp Val Ala Asn Gly Ala Leu Phe 
            100                 105                 110         


Gly Ser Ser Glu Thr Asp Lys Ala Phe His Lys Asn Tyr Pro Thr Ile 
        115                 120                 125             


Tyr His Leu Arg His Glu Leu Met Thr Asp Thr Ala Lys His Asp Leu 
    130                 135                 140                 


Arg Glu Val Tyr Leu Ala Ile His His Ile Val Lys Tyr Arg Gly Asn 
145                 150                 155                 160 


Phe Leu Asn Thr Ala Asp Lys Ile Asn Ala Glu Asn Ser Phe Asn Val 
                165                 170                 175     


Asp Leu Phe Ile Ala Ala Leu Asp Glu Tyr Asn Glu Phe Leu Glu Thr 
            180                 185                 190         


Pro Ile Thr Ser Ile Lys Asp Ala Gln Leu Phe Ser Asp Lys Leu Thr 
        195                 200                 205             


Asp Ile Asn Ala Arg Asn Lys Ser Val Arg Val Glu Asn Ala Met Ser 
    210                 215                 220                 


Glu Thr Tyr Asp Asp Lys Ser Lys Ile Phe Lys Ala Ile Leu Thr Ala 
225                 230                 235                 240 


Leu Val Gly Asn Thr Ala Asn Phe Gln Thr Ile Phe Asp Leu Ser Asp 
                245                 250                 255     


Leu Glu Lys Asp Glu Ala Lys Asn Phe Lys Phe Lys Leu Asp Leu Glu 
            260                 265                 270         


Asp Val Glu Thr Lys Leu Asp Val Val Arg Ala Lys Leu Ser Asp Glu 
        275                 280                 285             


Gln Asn Ala Phe Leu Glu Ala Val Leu Ile Ala Tyr Asp Gly Ile Thr 
    290                 295                 300                 


Leu Lys Met Ile Leu Gly Asp Tyr Lys Ser Ile Ser Gln Ser Met Ile 
305                 310                 315                 320 


Glu Ser Tyr Lys Ser His Gln Arg Asp Trp Lys Tyr Ile Lys Asn Asn 
                325                 330                 335     


Val Arg Leu Asn Glu Gln Lys Ile Glu Pro Asp Lys Asn Ser Val Lys 
            340                 345                 350         


Phe Phe Lys Leu Asp Pro Lys Lys Leu Ile Tyr Pro Ser Asn Leu Ala 
        355                 360                 365             


Tyr Leu Gln Val Ile Ser Ser Asn Glu Asp Glu His Arg Lys Gly Leu 
    370                 375                 380                 


Asp Tyr Phe Lys Thr Ala Ile Gln Asp Ala Asp Ile Leu Gln Arg Ile 
385                 390                 395                 400 


Glu Asn Asp Thr Phe Leu Pro Arg Gln Arg Thr Lys Arg Asn Gly Val 
                405                 410                 415     


Leu Pro Tyr Gln Leu His Leu Ala Glu Leu Glu Gln Ile Ile Lys Lys 
            420                 425                 430         


Gln Ser Lys Tyr Tyr Pro Phe Leu Ala Asn Ile Tyr Thr Gln Asp Asn 
        435                 440                 445             


Lys Thr Glu Asn Lys Leu Ile Gly Leu Leu Lys Phe Arg Val Pro Tyr 
    450                 455                 460                 


Tyr Val Gly Pro Leu Val Glu Ala Glu Lys Val Thr Gly Asp Gly Lys 
465                 470                 475                 480 


Asn His Trp Leu Ile Lys Lys Glu Leu Gln Glu Asn Thr Pro Ile Thr 
                485                 490                 495     


Pro Phe Asn Phe Asp Asp Val Val Asp Lys Asp Lys Ser Gly Glu Gln 
            500                 505                 510         


Phe Ile Lys Arg Ile Thr Gly Thr Asp Ser Tyr Leu Ile Gly Glu Pro 
        515                 520                 525             


Thr Leu Pro Glu Asn Ser Leu Leu Tyr Gln Lys Tyr Asn Val Leu Gln 
    530                 535                 540                 


Glu Leu Asn Asn Val Arg Asn Glu Arg His Gln Arg Leu Pro Ile Lys 
545                 550                 555                 560 


Val Lys Gln Asp Ile Phe Glu His Val Phe Lys Ile Asp Lys Asn Val 
                565                 570                 575     


Asn Ala Lys Lys Val Met Ala Tyr Leu Lys Leu Asn Gly Tyr Gly Asp 
            580                 585                 590         


Phe Gln Ile Ala Gly Leu Ser Asp Thr Arg Thr Gly Lys Phe Asn Ser 
        595                 600                 605             


Asn Leu Ser Ser Tyr Asn Tyr Phe Val Asp Leu Leu Gly Arg Glu Lys 
    610                 615                 620                 


Thr Glu Lys Ile Arg Glu Asp Arg Leu Glu Glu Ile Ile Glu Ile Gln 
625                 630                 635                 640 


Thr Val Phe Glu Asp Lys Ile Leu Val Ala Lys Arg Leu Ser Asn Leu 
                645                 650                 655     


Asp Phe Leu Thr Pro Gln Glu Lys Ser Lys Leu Ser Ala Lys His Tyr 
            660                 665                 670         


Thr Gly Trp Gly Arg Leu Ser Gln Lys Leu Leu Thr Thr Gln Phe Ile 
        675                 680                 685             


Lys Thr Ala Leu Ser Glu Ala Gly Asp Ile Ile Pro Gln Ser His Ser 
    690                 695                 700                 


Ile Ile Asp Leu Leu Tyr Tyr Thr Asp Lys Asn Leu Met Glu Ile Leu 
705                 710                 715                 720 


Asn Asp Lys Thr Phe Asn Val Arg Asn Trp Leu Thr Glu Gln Asn Lys 
                725                 730                 735     


Gly Thr Glu Ser Gly Asn Ser Leu Tyr Asp Gln Ile Asp Ala Leu Ala 
            740                 745                 750         


Gly Pro Lys Asp Ile Lys Arg Gly Ile Thr Gln Val Phe Ser Ile Ile 
        755                 760                 765             


Asp Asp Ile Lys Lys Ala Met Gly Ser Asn Pro Glu Thr Val Tyr Leu 
    770                 775                 780                 


Glu Phe Ala Arg Glu Thr Gln Thr Ser Arg Leu Thr Asn Ser Arg Leu 
785                 790                 795                 800 


Asn Arg Val Gln Glu Ile Tyr Asn Ser Pro Glu Leu Lys Thr Glu Phe 
                805                 810                 815     


Ala Tyr Leu Ala Lys Lys Leu Glu Ala Glu Thr Lys Glu Ser Ile His 
            820                 825                 830         


Asp Asp Arg Leu Tyr Leu Tyr Tyr Leu Gln Glu Gly Arg Asp Met Tyr 
        835                 840                 845             


Thr Gly Lys Glu Ile Pro Phe Asp Gln Ile Ser Ser Asn Tyr Asp Ile 
    850                 855                 860                 


Asp His Ile Ile Pro Gln Ala Phe Thr Lys Asp Asp Ser Leu Asp Asn 
865                 870                 875                 880 


Arg Val Leu Val Asn Arg Ala Thr Asn Ala Arg Lys Ser Asn Ser Pro 
                885                 890                 895     


Thr Phe Thr Asn Asp Ile Ile Asp Asn Arg Lys Ser Trp Trp Gln Ser 
            900                 905                 910         


Leu Val Lys Arg Gly Leu Met Ser Lys Glu Lys Phe Glu Arg Leu Thr 
        915                 920                 925             


Asp Lys Arg Lys Thr Phe Ser Glu Asn Gln Thr Asn His Phe Ile Ala 
    930                 935                 940                 


Arg Gln Leu Val Glu Thr Arg Gln Ile Ile Lys Asn Val Ala Asp Leu 
945                 950                 955                 960 


Ile Lys Asn Asn Tyr Asp Gly Thr Gln Ala Val Ala Ile Arg Ala Ser 
                965                 970                 975     


Leu Thr Gly Glu Met Arg Arg Tyr Leu Asp Trp Pro Lys Asn Arg Asp 
            980                 985                 990         


Met Asn Asp Tyr His His Ala His  Asp Ala Leu Met Met  Ala Thr Val 
        995                 1000                 1005             


Gly Lys  Tyr Val Asp Arg Arg  Gly Phe Phe Asp Asn  Gly Ser Val 
    1010                 1015                 1020             


Ser Asp  Gly Ala Gly Asn Ala  Tyr Asn Leu Tyr Thr  Lys Asp Trp 
    1025                 1030                 1035             


Leu Val  Ala Ala Arg Val Gly  Thr Arg Asn Asp Ser  Gln Arg Val 
    1040                 1045                 1050             


Asn Pro  Tyr Gly Phe Ile Val  Gly Ser Met Asn Ser  Lys Ala Val 
    1055                 1060                 1065             


Arg Gln  Gln Val Asn Lys Glu  Thr Gly Glu Ile Val  Trp Gly Asn 
    1070                 1075                 1080             


Glu Asn  Leu Asp Tyr Leu Arg  His Val Leu Ser Tyr  Lys Lys Ile 
    1085                 1090                 1095             


Leu Val  Thr Arg Arg Leu Ser  Gly Ser Ser Gly Arg  Leu Tyr Ala 
    1100                 1105                 1110             


Glu Thr  Leu Phe Ser Pro Asn  Pro Lys Ala Lys Leu  Ile Ala Gln 
    1115                 1120                 1125             


Lys Ala  Asn Arg Ser Val Ala  Leu Tyr Gly Gly Phe  Thr Lys Ala 
    1130                 1135                 1140             


Glu Ser  Ala Tyr Thr Ala Leu  Val Glu Phe Asn Lys  Lys Gly Asp 
    1145                 1150                 1155             


Arg Ser  Tyr Lys Leu Ile Lys  Val Pro Met Ala Ile  Ala Asn Arg 
    1160                 1165                 1170             


Val Asn  Asp Lys Gln Ile Thr  Val Thr Ala Tyr Ile  Ala Ser Leu 
    1175                 1180                 1185             


Asn Leu  Arg Asp Phe Ser Arg  Val Val Leu Glu His  Leu Pro Leu 
    1190                 1195                 1200             


Gly Thr  Leu Ile Arg Glu Ser  Asp Gly Ser Glu Phe  Tyr Ala Ala 
    1205                 1210                 1215             


Ser Ser  Glu Tyr Lys His Asn  Ala Lys Glu Leu Trp  Ala Pro Lys 
    1220                 1225                 1230             


Glu Ile  Leu Arg Ser Ser Lys  Lys Leu Asp Lys Ala  Thr Ala Asp 
    1235                 1240                 1245             


Asn Leu  Ile Asp Ile Phe Asp  Phe Leu Thr Asn Asp  Lys Thr Ile 
    1250                 1255                 1260             


Ser Asn  Phe Lys Phe Tyr Glu  Lys Asp Leu Leu His  Leu Lys Asn 
    1265                 1270                 1275             


Val Arg  Asp Lys Phe Val Glu  Ala Ser Asp Glu Ile  Lys Ile Lys 
    1280                 1285                 1290             


Val Leu  Ser Asp Val Ile Tyr  Glu Leu His Asn Asp  Ala Gly Trp 
    1295                 1300                 1305             


Arg Asp  Pro Phe Lys His Ile  Gln Glu Lys Pro Ala  Trp Thr Met 
    1310                 1315                 1320             


Leu Gln  Val Lys Gly Gly Ile  Lys Leu Ser Glu Lys  Ala Ala Ile 
    1325                 1330                 1335             


Val Tyr  Gln Ser Pro Thr Gly  Leu Phe Glu Thr Ile  Thr Ile Val 
    1340                 1345                 1350             


Gly Glu  
    1355 


<210> 306
<211> 1337
<212> PRT
<213> Listeria innocua


<220>
<223> Listeria innocua ATCC 33091

<400> 306
Met Lys Asn Met Lys Lys Pro Tyr Thr Ile Gly Leu Asp Ile Gly Thr 
1               5                   10                  15      


Asn Ser Val Gly Trp Ala Val Leu Thr Asp Gln Tyr Asp Leu Val Lys 
            20                  25                  30          


Arg Lys Met Lys Ile Ala Gly Asp Ser Glu Lys Lys Gln Ile Lys Lys 
        35                  40                  45              


Asn Phe Trp Gly Val Arg Leu Phe Asp Glu Gly Gln Thr Ala Ala Asp 
    50                  55                  60                  


Arg Arg Met Ala Arg Thr Ala Arg Arg Arg Ile Glu Arg Arg Arg Asn 
65                  70                  75                  80  


Arg Ile Ser Tyr Leu Gln Gly Ile Phe Ala Glu Glu Met Ser Lys Thr 
                85                  90                  95      


Asp Ala Asn Phe Phe Cys Arg Leu Ser Asp Ser Phe Tyr Val Asp Asn 
            100                 105                 110         


Glu Lys Arg Asn Ser Arg His Pro Phe Phe Ala Thr Ile Glu Glu Glu 
        115                 120                 125             


Val Glu Tyr His Lys Asn Tyr Pro Thr Ile Tyr His Leu Arg Glu Glu 
    130                 135                 140                 


Leu Val Asn Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala 
145                 150                 155                 160 


Leu Ala His Ile Ile Lys Tyr Arg Gly Asn Phe Leu Ile Glu Gly Ala 
                165                 170                 175     


Leu Asp Thr Gln Asn Thr Ser Val Asp Gly Ile Tyr Lys Gln Phe Ile 
            180                 185                 190         


Gln Thr Tyr Asn Gln Val Phe Ala Ser Gly Ile Glu Asp Gly Ser Leu 
        195                 200                 205             


Lys Lys Leu Glu Asp Asn Lys Asp Val Ala Lys Ile Leu Val Glu Lys 
    210                 215                 220                 


Val Thr Arg Lys Glu Lys Leu Glu Arg Ile Leu Lys Leu Tyr Pro Gly 
225                 230                 235                 240 


Glu Lys Ser Ala Gly Met Phe Ala Gln Phe Ile Ser Leu Ile Val Gly 
                245                 250                 255     


Ser Lys Gly Asn Phe Gln Lys Pro Phe Asp Leu Ile Glu Lys Ser Asp 
            260                 265                 270         


Ile Glu Cys Ala Lys Asp Ser Tyr Glu Glu Asp Leu Glu Ser Leu Leu 
        275                 280                 285             


Ala Leu Ile Gly Asp Glu Tyr Ala Glu Leu Phe Val Ala Ala Lys Asn 
    290                 295                 300                 


Ala Tyr Ser Ala Val Val Leu Ser Ser Ile Ile Thr Val Ala Glu Thr 
305                 310                 315                 320 


Glu Thr Asn Ala Lys Leu Ser Ala Ser Met Ile Glu Arg Phe Asp Thr 
                325                 330                 335     


His Glu Glu Asp Leu Gly Glu Leu Lys Ala Phe Ile Lys Leu His Leu 
            340                 345                 350         


Pro Lys His Tyr Glu Glu Ile Phe Ser Asn Thr Glu Lys His Gly Tyr 
        355                 360                 365             


Ala Gly Tyr Ile Asp Gly Lys Thr Lys Gln Ala Asp Phe Tyr Lys Tyr 
    370                 375                 380                 


Met Lys Met Thr Leu Glu Asn Ile Glu Gly Ala Asp Tyr Phe Ile Ala 
385                 390                 395                 400 


Lys Ile Glu Lys Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn 
                405                 410                 415     


Gly Ala Ile Pro His Gln Leu His Leu Glu Glu Leu Glu Ala Ile Leu 
            420                 425                 430         


His Gln Gln Ala Lys Tyr Tyr Pro Phe Leu Lys Glu Asn Tyr Asp Lys 
        435                 440                 445             


Ile Lys Ser Leu Val Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu 
    450                 455                 460                 


Ala Asn Gly Gln Ser Glu Phe Ala Trp Leu Thr Arg Lys Ala Asp Gly 
465                 470                 475                 480 


Glu Ile Arg Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser 
                485                 490                 495     


Ala Val Asp Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro 
            500                 505                 510         


Lys Glu Asn Val Leu Pro Lys His Ser Leu Cys Tyr Gln Lys Tyr Leu 
        515                 520                 525             


Val Tyr Asn Glu Leu Thr Lys Val Arg Tyr Ile Asn Asp Gln Gly Lys 
    530                 535                 540                 


Thr Ser Tyr Phe Ser Gly Gln Glu Lys Glu Gln Ile Phe Asn Asp Leu 
545                 550                 555                 560 


Phe Lys Gln Lys Arg Lys Val Lys Lys Lys Asp Leu Glu Leu Phe Leu 
                565                 570                 575     


Arg Asn Met Ser His Val Glu Ser Pro Thr Ile Glu Gly Leu Glu Asp 
            580                 585                 590         


Ser Phe Asn Ser Ser Tyr Ser Thr Tyr His Asp Leu Leu Lys Val Gly 
        595                 600                 605             


Ile Lys Gln Glu Ile Leu Asp Asn Pro Val Asn Thr Glu Met Leu Glu 
    610                 615                 620                 


Asn Ile Val Lys Ile Leu Thr Val Phe Glu Asp Lys Arg Met Ile Lys 
625                 630                 635                 640 


Glu Gln Leu Gln Gln Phe Ser Asp Val Leu Asp Gly Val Val Leu Lys 
                645                 650                 655     


Lys Leu Glu Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys 
            660                 665                 670         


Leu Leu Met Gly Ile Arg Asp Lys Gln Ser His Leu Thr Ile Leu Asp 
        675                 680                 685             


Tyr Leu Met Asn Asp Asp Gly Leu Asn Arg Asn Leu Met Gln Leu Ile 
    690                 695                 700                 


Asn Asp Ser Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gln Val 
705                 710                 715                 720 


Thr Thr Ala Asp Lys Asp Ile Gln Ser Ile Val Ala Asp Leu Ala Gly 
                725                 730                 735     


Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp 
            740                 745                 750         


Glu Leu Val Ser Val Met Gly Tyr Pro Pro Gln Thr Ile Val Val Glu 
        755                 760                 765             


Met Ala Arg Glu Asn Gln Thr Thr Gly Lys Gly Lys Asn Asn Ser Arg 
    770                 775                 780                 


Pro Arg Tyr Lys Ser Leu Glu Lys Ala Ile Lys Glu Phe Gly Ser Gln 
785                 790                 795                 800 


Ile Leu Lys Glu His Pro Thr Asp Asn Gln Glu Leu Arg Asn Asn Arg 
                805                 810                 815     


Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Gln 
            820                 825                 830         


Asp Leu Asp Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Val 
        835                 840                 845             


Pro Gln Ser Phe Ile Thr Asp Asn Ser Ile Asp Asn Leu Val Leu Thr 
    850                 855                 860                 


Ser Ser Ala Gly Asn Arg Glu Lys Gly Asp Asp Val Pro Pro Leu Glu 
865                 870                 875                 880 


Ile Val Arg Lys Arg Lys Val Phe Trp Glu Lys Leu Tyr Gln Gly Asn 
                885                 890                 895     


Leu Met Ser Lys Arg Lys Phe Asp Tyr Leu Thr Lys Ala Glu Arg Gly 
            900                 905                 910         


Gly Leu Thr Glu Ala Asp Lys Ala Arg Phe Ile His Arg Gln Leu Val 
        915                 920                 925             


Glu Thr Arg Gln Ile Thr Lys Asn Val Ala Asn Ile Leu His Gln Arg 
    930                 935                 940                 


Phe Asn Tyr Glu Lys Asp Asp His Gly Asn Thr Met Lys Gln Val Arg 
945                 950                 955                 960 


Ile Val Thr Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Lys Gln Phe 
                965                 970                 975     


Gln Leu Tyr Lys Val Arg Asp Val Asn Asp Tyr His His Ala His Asp 
            980                 985                 990         


Ala Tyr Leu Asn Gly Val Val Ala  Asn Thr Leu Leu Lys  Val Tyr Pro 
        995                 1000                 1005             


Gln Leu  Glu Pro Glu Phe Val  Tyr Gly Asp Tyr His  Gln Phe Asp 
    1010                 1015                 1020             


Trp Phe  Lys Ala Asn Lys Ala  Thr Ala Lys Lys Gln  Phe Tyr Thr 
    1025                 1030                 1035             


Asn Ile  Met Leu Phe Phe Ala  Gln Lys Asp Arg Ile  Ile Asp Glu 
    1040                 1045                 1050             


Asn Gly  Glu Ile Leu Trp Asp  Lys Lys Tyr Leu Asp  Thr Val Lys 
    1055                 1060                 1065             


Lys Val  Met Ser Tyr Arg Gln  Met Asn Ile Val Lys  Lys Thr Glu 
    1070                 1075                 1080             


Ile Gln  Lys Gly Glu Phe Ser  Lys Ala Thr Ile Lys  Pro Lys Gly 
    1085                 1090                 1095             


Asn Ser  Ser Lys Leu Ile Ser  Arg Lys Thr Asn Trp  Asp Pro Met 
    1100                 1105                 1110             


Lys Tyr  Gly Gly Leu Asp Ser  Pro Asn Met Ala Tyr  Ala Val Val 
    1115                 1120                 1125             


Ile Glu  Tyr Ala Lys Gly Lys  Asn Lys Leu Val Phe  Glu Lys Lys 
    1130                 1135                 1140             


Ile Ile  Arg Val Thr Ile Met  Glu Arg Lys Ala Phe  Glu Lys Asp 
    1145                 1150                 1155             


Glu Lys  Ala Phe Leu Glu Glu  Gln Gly Tyr Arg Gln  Pro Lys Val 
    1160                 1165                 1170             


Leu Ala  Lys Leu Pro Lys Tyr  Thr Leu Tyr Glu Cys  Glu Glu Gly 
    1175                 1180                 1185             


Arg Arg  Arg Met Leu Ala Ser  Ala Asn Glu Ala Gln  Lys Gly Asn 
    1190                 1195                 1200             


Gln Gln  Val Leu Pro Asn His  Leu Val Thr Leu Leu  His His Val 
    1205                 1210                 1215             


Ala Asn  Cys Glu Val Ser Asp  Gly Lys Ser Leu Asp  Tyr Ile Glu 
    1220                 1225                 1230             


Ser Asn  Arg Glu Met Phe Ala  Glu Leu Leu Ala His  Val Ser Glu 
    1235                 1240                 1245             


Phe Ala  Lys Arg Tyr Thr Leu  Ala Glu Ala Asn Leu  Asn Lys Ile 
    1250                 1255                 1260             


Asn Gln  Leu Phe Glu Gln Asn  Lys Glu Gly Asp Ile  Lys Ala Ile 
    1265                 1270                 1275             


Ala Gln  Ser Phe Val Asp Leu  Met Ala Phe Asn Ala  Met Gly Ala 
    1280                 1285                 1290             


Pro Ala  Ser Phe Lys Phe Phe  Glu Thr Thr Ile Glu  Arg Lys Arg 
    1295                 1300                 1305             


Tyr Asn  Asn Leu Lys Glu Leu  Leu Asn Ser Thr Ile  Ile Tyr Gln 
    1310                 1315                 1320             


Ser Ile  Thr Gly Leu Tyr Glu  Ser Arg Lys Arg Leu  Asp Asp 
    1325                 1330                 1335         


<210> 307
<211> 1334
<212> PRT
<213> Listeria innocua

<400> 307
Met Lys Lys Pro Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Leu Thr Asp Gln Tyr Asp Leu Val Lys Arg Lys Met 
            20                  25                  30          


Lys Ile Ala Gly Asp Ser Glu Lys Lys Gln Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Glu Gly Gln Thr Ala Ala Asp Arg Arg Met 
    50                  55                  60                  


Ala Arg Thr Ala Arg Arg Arg Ile Glu Arg Arg Arg Asn Arg Ile Ser 
65                  70                  75                  80  


Tyr Leu Gln Gly Ile Phe Ala Glu Glu Met Ser Lys Thr Asp Ala Asn 
                85                  90                  95      


Phe Phe Cys Arg Leu Ser Asp Ser Phe Tyr Val Asp Asn Glu Lys Arg 
            100                 105                 110         


Asn Ser Arg His Pro Phe Phe Ala Thr Ile Glu Glu Glu Val Glu Tyr 
        115                 120                 125             


His Lys Asn Tyr Pro Thr Ile Tyr His Leu Arg Glu Glu Leu Val Asn 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Tyr Arg Gly Asn Phe Leu Ile Glu Gly Ala Leu Asp Thr 
                165                 170                 175     


Gln Asn Thr Ser Val Asp Gly Ile Tyr Lys Gln Phe Ile Gln Thr Tyr 
            180                 185                 190         


Asn Gln Val Phe Ala Ser Gly Ile Glu Asp Gly Ser Leu Lys Lys Leu 
        195                 200                 205             


Glu Asp Asn Lys Asp Val Ala Lys Ile Leu Val Glu Lys Val Thr Arg 
    210                 215                 220                 


Lys Glu Lys Leu Glu Arg Ile Leu Lys Leu Tyr Pro Gly Glu Lys Ser 
225                 230                 235                 240 


Ala Gly Met Phe Ala Gln Phe Ile Ser Leu Ile Val Gly Ser Lys Gly 
                245                 250                 255     


Asn Phe Gln Lys Pro Phe Asp Leu Ile Glu Lys Ser Asp Ile Glu Cys 
            260                 265                 270         


Ala Lys Asp Ser Tyr Glu Glu Asp Leu Glu Ser Leu Leu Ala Leu Ile 
        275                 280                 285             


Gly Asp Glu Tyr Ala Glu Leu Phe Val Ala Ala Lys Asn Ala Tyr Ser 
    290                 295                 300                 


Ala Val Val Leu Ser Ser Ile Ile Thr Val Ala Glu Thr Glu Thr Asn 
305                 310                 315                 320 


Ala Lys Leu Ser Ala Ser Met Ile Glu Arg Phe Asp Thr His Glu Glu 
                325                 330                 335     


Asp Leu Gly Glu Leu Lys Ala Phe Ile Lys Leu His Leu Pro Lys His 
            340                 345                 350         


Tyr Glu Glu Ile Phe Ser Asn Thr Glu Lys His Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Asp Gly Lys Thr Lys Gln Ala Asp Phe Tyr Lys Tyr Met Lys Met 
    370                 375                 380                 


Thr Leu Glu Asn Ile Glu Gly Ala Asp Tyr Phe Ile Ala Lys Ile Glu 
385                 390                 395                 400 


Lys Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ala Ile 
                405                 410                 415     


Pro His Gln Leu His Leu Glu Glu Leu Glu Ala Ile Leu His Gln Gln 
            420                 425                 430         


Ala Lys Tyr Tyr Pro Phe Leu Lys Glu Asn Tyr Asp Lys Ile Lys Ser 
        435                 440                 445             


Leu Val Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu Ala Asn Gly 
    450                 455                 460                 


Gln Ser Glu Phe Ala Trp Leu Thr Arg Lys Ala Asp Gly Glu Ile Arg 
465                 470                 475                 480 


Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser Ala Val Asp 
                485                 490                 495     


Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro Lys Glu Asn 
            500                 505                 510         


Val Leu Pro Lys His Ser Leu Cys Tyr Gln Lys Tyr Leu Val Tyr Asn 
        515                 520                 525             


Glu Leu Thr Lys Val Arg Tyr Ile Asn Asp Gln Gly Lys Thr Ser Tyr 
    530                 535                 540                 


Phe Ser Gly Gln Glu Lys Glu Gln Ile Phe Asn Asp Leu Phe Lys Gln 
545                 550                 555                 560 


Lys Arg Lys Val Lys Lys Lys Asp Leu Glu Leu Phe Leu Arg Asn Met 
                565                 570                 575     


Ser His Val Glu Ser Pro Thr Ile Glu Gly Leu Glu Asp Ser Phe Asn 
            580                 585                 590         


Ser Ser Tyr Ser Thr Tyr His Asp Leu Leu Lys Val Gly Ile Lys Gln 
        595                 600                 605             


Glu Ile Leu Asp Asn Pro Val Asn Thr Glu Met Leu Glu Asn Ile Val 
    610                 615                 620                 


Lys Ile Leu Thr Val Phe Glu Asp Lys Arg Met Ile Lys Glu Gln Leu 
625                 630                 635                 640 


Gln Gln Phe Ser Asp Val Leu Asp Gly Val Val Leu Lys Lys Leu Glu 
                645                 650                 655     


Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Met 
            660                 665                 670         


Gly Ile Arg Asp Lys Gln Ser His Leu Thr Ile Leu Asp Tyr Leu Met 
        675                 680                 685             


Asn Asp Asp Gly Leu Asn Arg Asn Leu Met Gln Leu Ile Asn Asp Ser 
    690                 695                 700                 


Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gln Val Thr Thr Ala 
705                 710                 715                 720 


Asp Lys Asp Ile Gln Ser Ile Val Ala Asp Leu Ala Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val 
            740                 745                 750         


Ser Val Met Gly Tyr Pro Pro Gln Thr Ile Val Val Glu Met Ala Arg 
        755                 760                 765             


Glu Asn Gln Thr Thr Gly Lys Gly Lys Asn Asn Ser Arg Pro Arg Tyr 
    770                 775                 780                 


Lys Ser Leu Glu Lys Ala Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asp Asn Gln Glu Leu Arg Asn Asn Arg Leu Tyr Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Gln Asp Leu Asp 
            820                 825                 830         


Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Val Pro Gln Ser 
        835                 840                 845             


Phe Ile Thr Asp Asn Ser Ile Asp Asn Leu Val Leu Thr Ser Ser Ala 
    850                 855                 860                 


Gly Asn Arg Glu Lys Gly Asp Asp Val Pro Pro Leu Glu Ile Val Arg 
865                 870                 875                 880 


Lys Arg Lys Val Phe Trp Glu Lys Leu Tyr Gln Gly Asn Leu Met Ser 
                885                 890                 895     


Lys Arg Lys Phe Asp Tyr Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr 
            900                 905                 910         


Glu Ala Asp Lys Ala Arg Phe Ile His Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys Asn Val Ala Asn Ile Leu His Gln Arg Phe Asn Tyr 
    930                 935                 940                 


Glu Lys Asp Asp His Gly Asn Thr Met Lys Gln Val Arg Ile Val Thr 
945                 950                 955                 960 


Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Lys Gln Phe Gln Leu Tyr 
                965                 970                 975     


Lys Val Arg Asp Val Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Gly Val Val Ala Asn Thr Leu  Leu Lys Val Tyr Pro  Gln Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Asp  Tyr His Gln Phe Asp  Trp Phe Lys 
    1010                 1015                 1020             


Ala Asn  Lys Ala Thr Ala Lys  Lys Gln Phe Tyr Thr  Asn Ile Met 
    1025                 1030                 1035             


Leu Phe  Phe Ala Gln Lys Asp  Arg Ile Ile Asp Glu  Asn Gly Glu 
    1040                 1045                 1050             


Ile Leu  Trp Asp Lys Lys Tyr  Leu Asp Thr Val Lys  Lys Val Met 
    1055                 1060                 1065             


Ser Tyr  Arg Gln Met Asn Ile  Val Lys Lys Thr Glu  Ile Gln Lys 
    1070                 1075                 1080             


Gly Glu  Phe Ser Lys Ala Thr  Ile Lys Pro Lys Gly  Asn Ser Ser 
    1085                 1090                 1095             


Lys Leu  Ile Pro Arg Lys Thr  Asn Trp Asp Pro Met  Lys Tyr Gly 
    1100                 1105                 1110             


Gly Leu  Asp Ser Pro Asn Met  Ala Tyr Ala Val Val  Ile Glu Tyr 
    1115                 1120                 1125             


Ala Lys  Gly Lys Asn Lys Leu  Val Phe Glu Lys Lys  Ile Ile Arg 
    1130                 1135                 1140             


Val Thr  Ile Met Glu Arg Lys  Ala Phe Glu Lys Asp  Glu Lys Ala 
    1145                 1150                 1155             


Phe Leu  Glu Glu Gln Gly Tyr  Arg Gln Pro Lys Val  Leu Ala Lys 
    1160                 1165                 1170             


Leu Pro  Lys Tyr Thr Leu Tyr  Glu Cys Glu Glu Gly  Arg Arg Arg 
    1175                 1180                 1185             


Met Leu  Ala Ser Ala Asn Glu  Ala Gln Lys Gly Asn  Gln Gln Val 
    1190                 1195                 1200             


Leu Pro  Asn His Leu Val Thr  Leu Leu His His Ala  Ala Asn Cys 
    1205                 1210                 1215             


Glu Val  Ser Asp Gly Lys Ser  Leu Asp Tyr Ile Glu  Ser Asn Arg 
    1220                 1225                 1230             


Glu Met  Phe Ala Glu Leu Leu  Ala His Val Ser Glu  Phe Ala Lys 
    1235                 1240                 1245             


Arg Tyr  Thr Leu Ala Glu Ala  Asn Leu Asn Lys Ile  Asn Gln Leu 
    1250                 1255                 1260             


Phe Glu  Gln Asn Lys Glu Gly  Asp Ile Lys Ala Ile  Ala Gln Ser 
    1265                 1270                 1275             


Phe Val  Asp Leu Met Ala Phe  Asn Ala Met Gly Ala  Pro Ala Ser 
    1280                 1285                 1290             


Phe Lys  Phe Phe Glu Thr Thr  Ile Glu Arg Lys Arg  Tyr Asn Asn 
    1295                 1300                 1305             


Leu Lys  Glu Leu Leu Asn Ser  Thr Ile Ile Tyr Gln  Ser Ile Thr 
    1310                 1315                 1320             


Gly Leu  Tyr Glu Ser Arg Lys  Arg Leu Asp Asp 
    1325                 1330                 


<210> 308
<211> 1334
<212> PRT
<213> Listeria monocytogenes

<400> 308
Met Lys Asn Pro Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Leu Thr Asn Gln Tyr Asp Leu Val Lys Arg Lys Met 
            20                  25                  30          


Lys Val Ala Gly Asn Ser Asp Lys Lys Gln Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Asp Gly Gln Thr Ala Val Asp Arg Arg Met 
    50                  55                  60                  


Asn Arg Thr Ala Arg Arg Arg Ile Glu Arg Arg Arg Asn Arg Ile Ser 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Val Glu Met Ala Asn Ile Asp Ala Asn 
                85                  90                  95      


Phe Phe Cys Arg Leu Asn Asp Ser Phe Tyr Val Asp Ser Glu Lys Arg 
            100                 105                 110         


Asn Ser Arg His Pro Phe Phe Ala Thr Ile Glu Glu Glu Val Ala Tyr 
        115                 120                 125             


His Lys Asn Tyr Arg Thr Ile Tyr His Leu Arg Glu Glu Leu Val Asn 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Tyr Arg Gly Asn Phe Leu Ile Glu Gly Ala Leu Asp Thr 
                165                 170                 175     


Lys Asn Thr Ser Val Asp Gly Val Tyr Glu Gln Phe Ile Gln Thr Tyr 
            180                 185                 190         


Asn Gln Val Phe Met Ser Asn Ile Glu Glu Gly Thr Leu Ala Lys Val 
        195                 200                 205             


Glu Glu Asn Ile Glu Val Ala Asn Ile Leu Ala Gly Lys Phe Thr Arg 
    210                 215                 220                 


Arg Glu Lys Phe Glu Arg Ile Leu Gln Leu Tyr Pro Gly Glu Lys Ser 
225                 230                 235                 240 


Thr Gly Met Phe Ala Gln Phe Ile Ser Leu Ile Val Gly Ser Lys Gly 
                245                 250                 255     


Asn Phe Gln Lys Val Phe Asp Leu Ile Glu Lys Thr Asp Ile Glu Cys 
            260                 265                 270         


Ala Lys Asp Ser Tyr Glu Glu Asp Leu Glu Ala Leu Leu Ala Ile Ile 
        275                 280                 285             


Gly Asp Glu Tyr Ala Glu Leu Phe Val Ala Ala Lys Asn Thr Tyr Asn 
    290                 295                 300                 


Ala Val Val Leu Ser Ser Ile Ile Thr Val Thr Ala Thr Glu Thr Asn 
305                 310                 315                 320 


Ala Lys Leu Ser Ala Ser Met Ile Glu Arg Phe Asp Ala His Glu Lys 
                325                 330                 335     


Asp Leu Gly Glu Leu Lys Ala Phe Ile Lys Leu His Leu Pro Lys Gln 
            340                 345                 350         


Tyr Gln Glu Ile Phe Asn Asn Ala Ala Ile Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Asp Gly Lys Thr Lys Gln Val Asp Phe Tyr Lys Tyr Leu Lys Thr 
    370                 375                 380                 


Ile Leu Glu Asn Ile Glu Gly Ala Asp Tyr Phe Ile Ala Lys Ile Glu 
385                 390                 395                 400 


Glu Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ala Ile 
                405                 410                 415     


Pro His Gln Leu His Leu Glu Glu Leu Glu Ala Ile Ile His Gln Gln 
            420                 425                 430         


Ala Lys Tyr Tyr Pro Phe Leu Arg Glu Asp Tyr Glu Lys Ile Lys Ser 
        435                 440                 445             


Leu Val Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu Ala Lys Gly 
    450                 455                 460                 


Gln Ser Glu Phe Ala Trp Leu Thr Arg Lys Ala Asp Gly Glu Ile Arg 
465                 470                 475                 480 


Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser Ala Val Asp 
                485                 490                 495     


Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro Lys Glu Asn 
            500                 505                 510         


Val Leu Pro Lys His Ser Leu Cys Tyr Gln Lys Tyr Met Val Tyr Asn 
        515                 520                 525             


Glu Leu Thr Lys Val Arg Tyr Ile Asp Asp Gln Gly Lys Thr Asn Tyr 
    530                 535                 540                 


Phe Ser Gly Gln Glu Lys Gln Gln Ile Phe Asn Asp Leu Phe Lys Gln 
545                 550                 555                 560 


Lys Arg Lys Val Lys Lys Lys Asp Leu Glu Leu Phe Leu Arg Asn Ile 
                565                 570                 575     


Asn His Ile Glu Ser Pro Thr Ile Glu Gly Leu Glu Asp Ser Phe Asn 
            580                 585                 590         


Ala Ser Tyr Ala Thr Tyr His Asp Leu Leu Lys Val Gly Met Lys Gln 
        595                 600                 605             


Glu Ile Leu Asp Asn Pro Leu Asn Thr Glu Met Leu Glu Asp Ile Val 
    610                 615                 620                 


Lys Ile Leu Thr Val Phe Glu Asp Lys Pro Met Ile Lys Glu Gln Leu 
625                 630                 635                 640 


Gln Gln Phe Ser Asp Val Leu Asp Gly Gly Val Leu Lys Lys Leu Glu 
                645                 650                 655     


Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Val 
            660                 665                 670         


Gly Ile Arg Glu Lys Gln Ser His Leu Thr Ile Leu Asp Tyr Leu Met 
        675                 680                 685             


Asn Asp Asp Gly Leu Asn Arg Asn Leu Met Gln Leu Ile Asn Asp Ser 
    690                 695                 700                 


Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gln Val Ser Thr Thr 
705                 710                 715                 720 


Asp Lys Asp Leu Gln Ser Ile Val Ala Asp Leu Ala Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val 
            740                 745                 750         


Ser Ile Met Gly Tyr Pro Pro Gln Thr Ile Val Val Glu Met Ala Arg 
        755                 760                 765             


Glu Asn Gln Thr Thr Gly Lys Gly Lys Asn Asn Ser Lys Pro Arg Tyr 
    770                 775                 780                 


Lys Ser Leu Glu Lys Ala Ile Lys Glu Phe Gly Ser Lys Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asp Asn Gln Glu Leu Lys Asn Asn Arg Leu Tyr Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Gln Glu Leu Asp 
            820                 825                 830         


Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Val Pro Gln Ser 
        835                 840                 845             


Phe Ile Thr Asp Asn Ser Ile Asp Asn Leu Val Leu Thr Ser Ser Ala 
    850                 855                 860                 


Gly Asn Arg Glu Lys Gly Gly Asp Val Pro Pro Leu Glu Ile Val Arg 
865                 870                 875                 880 


Lys Arg Lys Val Phe Trp Glu Lys Leu Tyr Gln Gly Asn Leu Met Ser 
                885                 890                 895     


Lys Arg Lys Phe Asp Tyr Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr 
            900                 905                 910         


Asp Ala Asp Lys Ala Arg Phe Ile His Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys Asn Val Ala Asn Ile Leu His Gln Arg Phe Asn Asn 
    930                 935                 940                 


Glu Thr Asp Asn His Gly Asn Thr Met Glu Gln Val Arg Ile Val Thr 
945                 950                 955                 960 


Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Lys Gln Phe Gln Leu Tyr 
                965                 970                 975     


Lys Val Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Gly Val Val Ala Asn Thr Leu  Leu Lys Val Tyr Pro  Gln Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Glu  Tyr His Gln Phe Asp  Trp Phe Lys 
    1010                 1015                 1020             


Ala Asn  Lys Ala Thr Ala Lys  Lys Gln Phe Tyr Thr  Asn Ile Met 
    1025                 1030                 1035             


Leu Phe  Phe Gly Gln Lys Glu  Arg Ile Ile Asp Glu  Asn Gly Glu 
    1040                 1045                 1050             


Ile Leu  Trp Asp Lys Lys Tyr  Leu Glu Thr Ile Lys  Lys Val Leu 
    1055                 1060                 1065             


Asp Tyr  Arg Gln Met Asn Ile  Val Lys Lys Thr Glu  Ile Gln Lys 
    1070                 1075                 1080             


Gly Glu  Phe Ser Lys Ala Thr  Ile Lys Pro Lys Gly  Asn Ser Ser 
    1085                 1090                 1095             


Lys Leu  Ile Pro Arg Lys Glu  Asn Trp Asp Pro Met  Lys Tyr Gly 
    1100                 1105                 1110             


Gly Leu  Asp Ser Pro Asn Met  Ala Tyr Ala Val Ile  Ile Glu His 
    1115                 1120                 1125             


Ala Lys  Gly Lys Lys Lys Leu  Ile Phe Glu Lys Lys  Ile Ile Arg 
    1130                 1135                 1140             


Ile Thr  Ile Met Glu Arg Lys  Met Phe Glu Lys Asp  Glu Glu Ala 
    1145                 1150                 1155             


Phe Leu  Glu Glu Lys Gly Tyr  Arg His Pro Lys Val  Leu Thr Lys 
    1160                 1165                 1170             


Leu Pro  Lys Tyr Thr Leu Tyr  Glu Cys Glu Lys Gly  Arg Arg Arg 
    1175                 1180                 1185             


Met Leu  Ala Ser Ala Asn Glu  Ala Gln Lys Gly Asn  Gln Leu Val 
    1190                 1195                 1200             


Leu Ser  Asn His Leu Val Ser  Leu Leu Tyr His Ala  Lys Asn Cys 
    1205                 1210                 1215             


Glu Ala  Ser Asp Gly Lys Ser  Leu Lys Tyr Ile Glu  Ala His Arg 
    1220                 1225                 1230             


Glu Thr  Phe Ser Glu Leu Leu  Ala Gln Val Ser Glu  Phe Ala Thr 
    1235                 1240                 1245             


Arg Tyr  Thr Leu Ala Asp Ala  Asn Leu Ser Lys Ile  Asn Asn Leu 
    1250                 1255                 1260             


Phe Glu  Gln Asn Lys Glu Gly  Asp Ile Gln Ala Ile  Ala Gln Ser 
    1265                 1270                 1275             


Phe Val  Asp Leu Met Ala Phe  Asn Ala Met Gly Ala  Pro Ala Ser 
    1280                 1285                 1290             


Phe Lys  Phe Phe Glu Ala Thr  Ile Asp Arg Lys Arg  Tyr Thr Asn 
    1295                 1300                 1305             


Leu Lys  Glu Leu Leu Ser Ser  Thr Ile Ile Tyr Gln  Ser Ile Thr 
    1310                 1315                 1320             


Gly Leu  Tyr Glu Ser Arg Lys  Arg Leu Asp Asp 
    1325                 1330                 


<210> 309
<211> 1334
<212> PRT
<213> Listeria monocytogenes


<220>
<223> Listeria monocytogenes FSL J1-194

<400> 309
Met Lys Asn Pro Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Leu Thr Asp Gln Tyr Asp Leu Val Lys Arg Lys Met 
            20                  25                  30          


Lys Val Ala Gly Asn Ser Asp Lys Lys Gln Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Asp Gly Gln Thr Ala Val Asp Arg Arg Met 
    50                  55                  60                  


Asn Arg Thr Ala Arg Arg Arg Ile Glu Arg Arg Arg Asn Arg Ile Ser 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Val Glu Met Ala Asn Ile Asp Ala Asn 
                85                  90                  95      


Phe Phe Cys Arg Leu Asn Asp Ser Phe Tyr Val Asp Ser Glu Lys Arg 
            100                 105                 110         


Asn Ser Arg His Pro Phe Phe Ala Thr Ile Glu Glu Glu Val Ala Tyr 
        115                 120                 125             


His Lys Asn Tyr Arg Thr Ile Tyr His Leu Arg Glu Glu Leu Val Asn 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Tyr Arg Gly Asn Phe Leu Ile Glu Gly Ala Leu Asp Thr 
                165                 170                 175     


Lys Asn Thr Ser Val Asp Glu Val Tyr Lys Gln Phe Ile Gln Thr Tyr 
            180                 185                 190         


Asn Gln Val Phe Met Ser Asn Ile Glu Glu Gly Ala Leu Ala Lys Val 
        195                 200                 205             


Glu Glu Asn Thr Glu Val Ala Ser Ile Leu Ala Gly Lys Phe Thr Arg 
    210                 215                 220                 


Arg Glu Lys Phe Glu Arg Ile Leu Arg Leu Tyr Pro Gly Glu Lys Ser 
225                 230                 235                 240 


Thr Gly Met Phe Ala Gln Phe Ile Ser Leu Ile Val Gly Asn Lys Gly 
                245                 250                 255     


Asn Phe Gln Lys Val Phe Asn Leu Val Glu Lys Thr Asp Ile Glu Cys 
            260                 265                 270         


Ala Lys Asp Ser Tyr Glu Glu Asp Leu Glu Ala Leu Leu Ala Ile Ile 
        275                 280                 285             


Gly Asp Glu Tyr Ala Glu Leu Phe Val Ala Ala Lys Asn Thr Tyr Asn 
    290                 295                 300                 


Ala Val Val Leu Ser Ser Ile Ile Thr Val Thr Ala Thr Glu Thr Asn 
305                 310                 315                 320 


Ala Lys Leu Ser Ala Ser Met Ile Glu Arg Phe Asp Ala His Glu Lys 
                325                 330                 335     


Glu Leu Gly Glu Leu Lys Ala Phe Ile Lys Leu His Leu Pro Lys Gln 
            340                 345                 350         


Tyr Gln Glu Ile Phe Asn Asn Ala Glu Ile Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Asp Gly Lys Thr Lys Gln Val Asp Phe Tyr Lys Tyr Leu Lys Thr 
    370                 375                 380                 


Thr Leu Glu Asn Val Glu Gly Ala Asp Tyr Phe Ile Thr Lys Ile Glu 
385                 390                 395                 400 


Glu Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Val Ile 
                405                 410                 415     


Pro His Gln Leu His Leu Glu Glu Leu Glu Ala Ile Leu His Gln Gln 
            420                 425                 430         


Ala Lys Tyr Tyr Pro Phe Leu Arg Glu Gly Tyr Asp Lys Ile Lys Ser 
        435                 440                 445             


Leu Val Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu Ala Asn Gly 
    450                 455                 460                 


Gln Ser Glu Phe Ala Trp Leu Thr Arg Lys Asp Asp Gly Glu Ile Arg 
465                 470                 475                 480 


Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser Ala Val Asp 
                485                 490                 495     


Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro Lys Glu Asn 
            500                 505                 510         


Val Leu Pro Lys His Ser Leu Cys Tyr Gln Lys Tyr Met Val Tyr Asn 
        515                 520                 525             


Glu Leu Thr Lys Ile Arg Tyr Ile Asp Asp Gln Gly Lys Thr Asn Tyr 
    530                 535                 540                 


Phe Ser Gly Arg Glu Lys Gln Gln Ile Phe Asn Asp Leu Phe Lys Gln 
545                 550                 555                 560 


Lys Arg Lys Val Lys Lys Lys Asp Leu Glu Leu Phe Leu Arg Asn Ile 
                565                 570                 575     


Asn His Ile Glu Ser Pro Thr Ile Glu Gly Leu Glu Asp Ser Phe Asn 
            580                 585                 590         


Ala Ser Tyr Ala Thr Tyr His Asp Leu Leu Lys Val Gly Leu Lys Gln 
        595                 600                 605             


Glu Ile Leu Asp Asn Pro Leu Asn Thr Glu Ile Leu Glu Asp Ile Val 
    610                 615                 620                 


Lys Ile Leu Thr Val Phe Glu Asp Lys Arg Met Ile Lys Glu Gln Leu 
625                 630                 635                 640 


Glu Gln Phe Ser Asp Val Leu Asp Gly Val Val Leu Lys Lys Leu Glu 
                645                 650                 655     


Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Val 
            660                 665                 670         


Gly Ile Arg Asp Lys Gln Ser His Leu Thr Ile Leu Asp Tyr Leu Met 
        675                 680                 685             


Asn Asp Asp Gly Leu Asn Arg Asn Leu Met Gln Leu Ile Asn Asp Ser 
    690                 695                 700                 


Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gln Val Ser Thr Thr 
705                 710                 715                 720 


Asp Lys Asp Leu Gln Ser Ile Val Ala Asp Leu Ala Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val 
            740                 745                 750         


Ser Ile Met Gly Tyr Pro Pro Gln Thr Ile Val Val Glu Met Ala Arg 
        755                 760                 765             


Glu Asn Gln Thr Thr Gly Lys Gly Lys Asn Asn Ser Lys Pro Arg Tyr 
    770                 775                 780                 


Lys Ser Leu Glu Lys Ala Ile Lys Asp Phe Gly Ser Gln Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asp Asn Gln Glu Leu Lys Asn Asn Arg Leu Tyr Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Ile Tyr Thr Gly Gln Glu Leu Asp 
            820                 825                 830         


Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Val Pro Gln Ser 
        835                 840                 845             


Phe Ile Thr Asp Asn Ser Ile Asp Asn Leu Val Leu Thr Ser Ser Ala 
    850                 855                 860                 


Gly Asn Arg Glu Lys Gly Gly Asp Val Pro Pro Leu Glu Ile Val Arg 
865                 870                 875                 880 


Lys Arg Lys Val Phe Trp Glu Lys Leu Tyr Gln Gly Asn Leu Met Ser 
                885                 890                 895     


Lys Arg Lys Phe Asp Tyr Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr 
            900                 905                 910         


Glu Ala Asp Lys Ala Arg Phe Ile His Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys Asn Val Ala Asn Ile Leu His Gln Arg Phe Asn Lys 
    930                 935                 940                 


Glu Thr Asp Asn His Gly Asn Thr Met Glu Gln Val Arg Ile Val Thr 
945                 950                 955                 960 


Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Lys Gln Phe Gln Leu Tyr 
                965                 970                 975     


Lys Val Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Gly Val Val Ala Asn Thr Leu  Leu Lys Val Tyr Pro  Gln Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Glu  Tyr His Gln Phe Asp  Trp Phe Lys 
    1010                 1015                 1020             


Ala Asn  Lys Ala Thr Ala Lys  Lys Gln Phe Tyr Thr  Asn Ile Met 
    1025                 1030                 1035             


Leu Phe  Phe Ala Gln Lys Glu  Arg Ile Ile Asp Glu  Asn Gly Glu 
    1040                 1045                 1050             


Ile Leu  Trp Asp Lys Lys Tyr  Leu Glu Thr Ile Lys  Lys Val Leu 
    1055                 1060                 1065             


Asp Tyr  Arg Gln Ile Asn Ile  Val Lys Lys Thr Glu  Ile Gln Lys 
    1070                 1075                 1080             


Gly Glu  Phe Ser Lys Ala Thr  Ile Lys Pro Lys Gly  Asn Ser Ser 
    1085                 1090                 1095             


Lys Leu  Ile Pro Arg Lys Glu  Asn Trp Asp Pro Met  Lys Tyr Gly 
    1100                 1105                 1110             


Gly Leu  Asp Ser Pro Asn Met  Ala Tyr Ala Val Ile  Ile Glu His 
    1115                 1120                 1125             


Ala Lys  Gly Lys Lys Lys Ile  Val Ile Glu Lys Lys  Leu Ile Gln 
    1130                 1135                 1140             


Ile Asn  Ile Met Glu Arg Lys  Met Phe Glu Lys Asp  Glu Glu Ala 
    1145                 1150                 1155             


Phe Leu  Glu Glu Lys Gly Tyr  His Gln Pro Lys Val  Leu Thr Lys 
    1160                 1165                 1170             


Leu Pro  Lys Tyr Thr Leu Tyr  Glu Cys Glu Lys Gly  Arg Arg Arg 
    1175                 1180                 1185             


Met Leu  Ser Ser Ala Asn Glu  Ala Gln Lys Gly Asn  Gln Leu Val 
    1190                 1195                 1200             


Leu Ser  Asn His Leu Val Ser  Leu Leu Tyr His Ala  Lys Asn Cys 
    1205                 1210                 1215             


Glu Ala  Ser Asp Gly Lys Ser  Leu Lys Tyr Ile Glu  Ala His Arg 
    1220                 1225                 1230             


Glu Thr  Phe Ser Glu Leu Leu  Ala Gln Val Ser Glu  Phe Ala Thr 
    1235                 1240                 1245             


Lys Tyr  Thr Leu Ala Asp Ala  Asn Leu Ser Lys Ile  Asn Asn Leu 
    1250                 1255                 1260             


Phe Glu  Gln Asn Lys Glu Gly  Asp Ile Lys Ala Ile  Ala Gln Ser 
    1265                 1270                 1275             


Phe Val  Asp Leu Met Ala Phe  Asn Ala Met Gly Ala  Pro Ala Ser 
    1280                 1285                 1290             


Phe Lys  Phe Phe Glu Ala Thr  Ile Asp Arg Lys Arg  Tyr Thr Asn 
    1295                 1300                 1305             


Leu Lys  Glu Leu Leu Ser Ser  Thr Ile Ile Tyr Gln  Ser Ile Thr 
    1310                 1315                 1320             


Gly Leu  Tyr Glu Ser Arg Lys  Arg Leu Asp Asp 
    1325                 1330                 


<210> 310
<211> 1334
<212> PRT
<213> Listeria monocytogenes


<220>
<223> Listeria monocytogenes FSL J1-208

<400> 310
Met Lys Asn Pro Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Leu Thr Asp Gln Tyr Asp Leu Val Lys Arg Lys Met 
            20                  25                  30          


Lys Val Ala Gly Asn Ser Asp Lys Lys Gln Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Glu Gly Glu Thr Ala Ala Asp Arg Arg Met 
    50                  55                  60                  


Asn Arg Thr Ala Arg Arg Arg Ile Glu Arg Arg Arg Asn Arg Ile Ser 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Leu Glu Met Ala Asn Ile Asp Ala Asn 
                85                  90                  95      


Phe Phe Cys Arg Leu Asn Asp Ser Phe Tyr Val Asp Ser Glu Lys Arg 
            100                 105                 110         


Asn Ser Arg His Pro Phe Phe Ala Thr Ile Glu Glu Glu Val Ala Tyr 
        115                 120                 125             


His Lys Asn Tyr Arg Thr Ile Tyr His Leu Arg Glu Glu Leu Val Asn 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Tyr Arg Gly Asn Phe Leu Ile Glu Gly Ala Leu Asp Thr 
                165                 170                 175     


Lys Asn Thr Ser Val Asp Gly Val Tyr Lys Gln Phe Ile Gln Thr Tyr 
            180                 185                 190         


Asn Gln Val Phe Ile Ser Asn Ile Glu Glu Gly Thr Leu Ala Lys Met 
        195                 200                 205             


Glu Glu Asn Thr Thr Val Ala Asp Ile Leu Ala Gly Lys Phe Thr Arg 
    210                 215                 220                 


Lys Glu Lys Leu Glu Arg Ile Leu Gln Leu Tyr Pro Gly Glu Lys Ser 
225                 230                 235                 240 


Thr Gly Met Phe Ala Gln Phe Ile Ser Leu Ile Val Gly Ser Lys Gly 
                245                 250                 255     


Asn Phe Gln Lys Val Phe Asp Leu Val Glu Lys Thr Asp Ile Glu Cys 
            260                 265                 270         


Ala Lys Asp Ser Tyr Glu Glu Asp Leu Glu Ala Leu Leu Ala Ile Ile 
        275                 280                 285             


Gly Asp Glu Tyr Ala Glu Leu Phe Val Ala Ala Lys Asn Thr Tyr Asn 
    290                 295                 300                 


Ala Val Val Leu Ser Ser Ile Ile Thr Val Thr Asp Thr Glu Thr Asn 
305                 310                 315                 320 


Ala Lys Leu Ser Ala Ser Met Ile Glu Arg Phe Asp Ala His Glu Lys 
                325                 330                 335     


Asp Leu Ser Glu Leu Lys Ala Phe Ile Lys Leu His Leu Pro Lys Gln 
            340                 345                 350         


Tyr Glu Glu Ile Phe Ser Asn Val Ala Ile Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Asp Gly Lys Thr Lys Gln Val Asp Phe Tyr Lys Tyr Leu Lys Thr 
    370                 375                 380                 


Leu Leu Glu Asn Ile Glu Gly Ala Asp Tyr Phe Ile Ala Lys Ile Glu 
385                 390                 395                 400 


Glu Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ala Ile 
                405                 410                 415     


Pro His Gln Leu His Leu Glu Glu Leu Glu Ala Ile Leu His Gln Gln 
            420                 425                 430         


Ala Lys Tyr Tyr Pro Phe Leu Lys Glu Ala Tyr Asp Lys Ile Lys Ser 
        435                 440                 445             


Leu Val Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu Ala Asn Gly 
    450                 455                 460                 


Gln Ser Asp Phe Ala Trp Leu Thr Arg Lys Ala Asp Gly Glu Ile Arg 
465                 470                 475                 480 


Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser Ala Val Asp 
                485                 490                 495     


Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro Lys Glu Asn 
            500                 505                 510         


Val Leu Pro Lys His Ser Leu Tyr Tyr Gln Lys Tyr Met Val Tyr Asn 
        515                 520                 525             


Glu Leu Thr Lys Val Arg Tyr Ile Asp Asp Gln Gly Lys Thr Asn Tyr 
    530                 535                 540                 


Phe Ser Gly Gln Glu Lys Gln Gln Ile Phe Asn Asp Tyr Phe Lys Gln 
545                 550                 555                 560 


Lys Arg Lys Val Ser Lys Lys Asp Leu Glu Gln Phe Leu Arg Asn Met 
                565                 570                 575     


Ser His Ile Glu Ser Pro Thr Ile Glu Gly Leu Glu Asp Ser Phe Asn 
            580                 585                 590         


Ser Ser Tyr Ala Thr Tyr His Asp Leu Leu Lys Val Gly Ile Lys Gln 
        595                 600                 605             


Glu Val Leu Glu Asn Pro Leu Asn Thr Glu Met Leu Glu Asp Ile Val 
    610                 615                 620                 


Lys Ile Leu Thr Val Phe Glu Asp Lys Arg Met Ile Lys Glu Gln Leu 
625                 630                 635                 640 


Gln Gln Phe Ser Asp Val Leu Asp Gly Ala Val Leu Lys Lys Leu Glu 
                645                 650                 655     


Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Val 
            660                 665                 670         


Gly Ile Arg Asp Lys Gln Ser His Leu Thr Ile Leu Asp Tyr Leu Met 
        675                 680                 685             


Asn Asp Asp Gly Leu Asn Arg Asn Leu Met Gln Leu Ile Asn Asp Ser 
    690                 695                 700                 


Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gln Val Ser Thr Thr 
705                 710                 715                 720 


Asp Lys Asp Leu Gln Ser Ile Val Ala Asp Leu Ala Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val 
            740                 745                 750         


Ser Ile Met Gly Tyr Pro Pro Gln Thr Ile Val Val Glu Met Ala Arg 
        755                 760                 765             


Glu Asn Gln Thr Thr Val Lys Gly Lys Asn Asn Ser Arg Pro Arg Tyr 
    770                 775                 780                 


Lys Ser Leu Glu Lys Ala Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asp Asn Gln Glu Leu Arg Asn Asn Arg Leu Tyr Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Gln Glu Leu Asp 
            820                 825                 830         


Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Val Pro Gln Ser 
        835                 840                 845             


Phe Ile Thr Asp Asn Ser Ile Asp Asn Leu Val Leu Thr Ser Ser Ala 
    850                 855                 860                 


Gly Asn Arg Glu Lys Gly Asp Asp Val Pro Pro Leu Glu Ile Val Arg 
865                 870                 875                 880 


Lys Arg Lys Val Phe Trp Glu Lys Leu Phe Gln Gly Asn Leu Met Ser 
                885                 890                 895     


Lys Arg Lys Phe Asp Tyr Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr 
            900                 905                 910         


Glu Ala Asp Lys Ala Thr Phe Ile His Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys Asn Val Ala Asn Ile Leu His Gln Arg Phe Asn Asn 
    930                 935                 940                 


Glu Thr Asp Asn His Gly Asn Asn Met Glu Gln Val Arg Ile Val Met 
945                 950                 955                 960 


Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Lys Gln Phe Gln Leu Tyr 
                965                 970                 975     


Lys Val Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Gly Val Val Ala Asn Thr Leu  Leu Lys Val Tyr Pro  Gln Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Glu  Tyr His Gln Phe Asp  Trp Phe Lys 
    1010                 1015                 1020             


Ala Asn  Lys Ala Thr Ala Lys  Lys Gln Phe Tyr Thr  Asn Ile Met 
    1025                 1030                 1035             


Leu Phe  Phe Ala Gln Lys Glu  Arg Ile Ile Asp Glu  Asn Gly Glu 
    1040                 1045                 1050             


Ile Leu  Trp Asp Lys Lys Tyr  Leu Glu Thr Ile Lys  Lys Val Leu 
    1055                 1060                 1065             


Asp Tyr  Arg Gln Met Asn Ile  Val Lys Lys Thr Glu  Ile Gln Lys 
    1070                 1075                 1080             


Gly Glu  Phe Ser Lys Ala Thr  Ile Lys Pro Lys Gly  Asn Ser Ser 
    1085                 1090                 1095             


Lys Leu  Ile Pro Arg Lys Glu  Asn Trp Asp Pro Met  Lys Tyr Gly 
    1100                 1105                 1110             


Gly Leu  Asp Ser Pro Asn Met  Ala Tyr Ala Val Ile  Ile Glu His 
    1115                 1120                 1125             


Ala Lys  Gly Lys Lys Lys Val  Val Phe Glu Lys Lys  Ile Ile Arg 
    1130                 1135                 1140             


Ile Thr  Ile Met Glu Arg Lys  Ala Phe Glu Lys Asp  Glu Lys Ser 
    1145                 1150                 1155             


Phe Leu  Glu Lys Gln Gly Tyr  Arg Gln Pro Lys Val  Leu Thr Lys 
    1160                 1165                 1170             


Leu Pro  Lys Tyr Thr Leu Tyr  Glu Cys Glu Asn Gly  Arg Arg Arg 
    1175                 1180                 1185             


Met Leu  Ala Ser Ala Asn Glu  Ala Gln Lys Gly Asn  Gln Gln Val 
    1190                 1195                 1200             


Leu Lys  Gly Gln Leu Ile Thr  Leu Leu His His Ala  Lys Asn Cys 
    1205                 1210                 1215             


Glu Ala  Ser Asp Gly Lys Ser  Leu Asp Tyr Ile Glu  Ser Asn Arg 
    1220                 1225                 1230             


Glu Met  Phe Gly Glu Leu Leu  Ala His Val Ser Glu  Phe Ala Lys 
    1235                 1240                 1245             


Arg Tyr  Thr Leu Ala Asp Ala  Asn Leu Ser Lys Ile  Asn Gln Leu 
    1250                 1255                 1260             


Phe Glu  Gln Asn Lys Asp Asn  Asp Ile Lys Val Ile  Ala Gln Ser 
    1265                 1270                 1275             


Phe Val  Asn Leu Met Ala Phe  Asn Ala Met Gly Ala  Pro Ala Ser 
    1280                 1285                 1290             


Phe Lys  Phe Phe Glu Ala Thr  Ile Glu Arg Lys Arg  Tyr Thr Asn 
    1295                 1300                 1305             


Leu Lys  Glu Leu Leu Ser Ala  Thr Ile Ile Tyr Gln  Ser Ile Thr 
    1310                 1315                 1320             


Gly Leu  Tyr Glu Ala Arg Lys  Arg Leu Asp Gly 
    1325                 1330                 


<210> 311
<211> 1334
<212> PRT
<213> Listeria monocytogenes


<220>
<223> Listeria monocytogenes FSL N3-165

<400> 311
Met Lys Lys Pro Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Leu Thr Asp Gln Tyr Asp Leu Val Lys Arg Lys Met 
            20                  25                  30          


Lys Ile Ser Gly Asp Ser Glu Lys Lys Gln Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Glu Lys Gly Glu Thr Ala Ala Lys Arg Arg Met 
    50                  55                  60                  


Ser Arg Thr Ala Arg Arg Arg Ile Glu Arg Arg Arg Asn Arg Ile Ser 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Ile Gln Met Asn Glu Val Asp Asp Asn 
                85                  90                  95      


Phe Phe Asn Arg Leu Lys Glu Ser Phe Tyr Ala Glu Ser Asp Lys Lys 
            100                 105                 110         


Tyr Asn Arg His Pro Phe Phe Gly Thr Val Glu Glu Glu Val Ala Tyr 
        115                 120                 125             


Tyr Lys Asp Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ile Asp 
    130                 135                 140                 


Ser Gln Lys Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Ala Leu Asp Thr 
                165                 170                 175     


Lys Asn Thr Ser Ile Asp Glu Met Phe Lys Gln Phe Leu Gln Ile Tyr 
            180                 185                 190         


Asn Gln Val Phe Ala Asn Asp Ile Glu Glu Ala Ser Leu Lys Lys Thr 
        195                 200                 205             


Glu Lys Asn Gln Glu Val Ala Gln Ile Leu Ala Glu Lys Phe Thr Arg 
    210                 215                 220                 


Lys Asp Lys Leu Asp Lys Ile Leu Ser Leu Tyr Pro Gly Glu Lys Thr 
225                 230                 235                 240 


Thr Gly Val Phe Ala Gln Phe Val Asn Ile Ile Val Gly Ser Thr Gly 
                245                 250                 255     


Lys Phe Lys Lys His Phe Asn Leu His Glu Lys Lys Asp Ile Asn Cys 
            260                 265                 270         


Ala Glu Asp Thr Tyr Asp Thr Asp Leu Glu Ser Leu Leu Ala Ile Ile 
        275                 280                 285             


Gly Asp Glu Phe Ala Glu Val Phe Val Ala Ala Lys Asn Ala Tyr Asn 
    290                 295                 300                 


Ala Val Val Leu Ser Asn Ile Ile Thr Val Thr Asp Ser Thr Thr Arg 
305                 310                 315                 320 


Ala Lys Leu Ser Ala Ser Leu Ile Glu Arg Phe Glu Asn His Lys Glu 
                325                 330                 335     


Asp Leu Lys Lys Met Lys Arg Phe Val Arg Thr Tyr Leu Pro Glu Lys 
            340                 345                 350         


Tyr Asp Glu Ile Phe Asp Asp Thr Glu Lys His Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Ser Gly Lys Thr Lys Gln Ala Asp Phe Tyr Lys Tyr Met Lys Ala 
    370                 375                 380                 


Thr Leu Glu Lys Ile Glu Gly Ala Asp Tyr Phe Ile Ala Lys Ile Glu 
385                 390                 395                 400 


Glu Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Val Ile 
                405                 410                 415     


Pro His Gln Leu His Leu Glu Glu Leu Glu Ala Ile Leu His Gln Gln 
            420                 425                 430         


Ala Lys Tyr Tyr Pro Phe Leu Arg Glu Asp Tyr Glu Lys Ile Lys Ser 
        435                 440                 445             


Leu Val Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu Ala Lys Gly 
    450                 455                 460                 


Gln Ser Glu Phe Ala Trp Leu Thr Arg Lys Ala Asp Gly Glu Ile Arg 
465                 470                 475                 480 


Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser Ala Val Asp 
                485                 490                 495     


Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro Lys Glu Asn 
            500                 505                 510         


Val Leu Pro Lys His Ser Leu Cys Tyr Gln Lys Tyr Met Val Tyr Asn 
        515                 520                 525             


Glu Leu Thr Lys Val Arg Tyr Ile Asp Asp Gln Gly Lys Thr Asn Tyr 
    530                 535                 540                 


Phe Ser Gly Gln Glu Lys Gln Gln Ile Phe Asn Asp Leu Phe Lys Gln 
545                 550                 555                 560 


Lys Arg Lys Val Lys Lys Lys Asp Leu Glu Leu Phe Leu Arg Asn Ile 
                565                 570                 575     


Asn Gln Ile Glu Ser Pro Thr Ile Glu Gly Leu Glu Asp Ser Phe Asn 
            580                 585                 590         


Ala Ser Tyr Ala Thr Tyr His Asp Leu Leu Lys Val Gly Met Lys Gln 
        595                 600                 605             


Glu Ile Leu Asp Asn Pro Leu Asn Thr Glu Met Leu Glu Asp Ile Val 
    610                 615                 620                 


Lys Ile Leu Thr Val Phe Glu Asp Lys Arg Met Ile Lys Glu Gln Leu 
625                 630                 635                 640 


Gln Gln Phe Ser Asp Val Leu Asp Gly Thr Val Leu Lys Lys Leu Glu 
                645                 650                 655     


Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Val 
            660                 665                 670         


Gly Ile Arg Asp Lys Gln Ser His Leu Thr Ile Leu Asp Tyr Leu Met 
        675                 680                 685             


Asn Asp Asp Gly Leu Asn Arg Asn Leu Met Gln Leu Ile Asn Asp Ser 
    690                 695                 700                 


Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gln Val Ser Thr Thr 
705                 710                 715                 720 


Asp Lys Asp Leu Gln Ser Ile Val Ala Glu Leu Ala Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val 
            740                 745                 750         


Ser Val Met Gly Tyr Pro Pro Gln Thr Ile Val Val Glu Met Ala Arg 
        755                 760                 765             


Glu Asn Gln Thr Thr Asn Lys Gly Lys Asn Asn Ser Lys Pro Arg Tyr 
    770                 775                 780                 


Lys Ser Leu Glu Lys Ala Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asp Asn Gln Glu Leu Lys Asn Asn Arg Leu Tyr Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Gln Glu Leu Asp 
            820                 825                 830         


Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Val Pro Gln Ser 
        835                 840                 845             


Phe Ile Thr Asp Asn Ser Val Asp Asn Leu Val Leu Thr Ser Ser Ala 
    850                 855                 860                 


Gly Asn Arg Glu Lys Gly Asp Asn Val Pro Pro Leu Glu Ile Val Gln 
865                 870                 875                 880 


Lys Arg Lys Ile Phe Trp Glu Lys Leu Tyr Gln Gly Asn Leu Met Ser 
                885                 890                 895     


Lys Arg Lys Phe Asp Tyr Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr 
            900                 905                 910         


Glu Ala Asp Lys Ala Arg Phe Ile His Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys Asn Val Ala Asn Ile Leu His Gln Arg Phe Asn Tyr 
    930                 935                 940                 


Lys Thr Asp Gly Asn Lys Asp Thr Met Glu Thr Val Arg Ile Val Thr 
945                 950                 955                 960 


Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Lys Gln Phe Gln Phe Tyr 
                965                 970                 975     


Lys Val Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Gly Val Val Ala Asn Thr Leu  Leu Lys Val Tyr Pro  Gln Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Glu  Tyr His Gln Phe Gly  Trp Phe Lys 
    1010                 1015                 1020             


Ala Asn  Lys Ala Thr Ala Lys  Lys Gln Phe Tyr Thr  Asn Ile Met 
    1025                 1030                 1035             


Leu Phe  Phe Ala Gln Lys Asp  Arg Ile Ile Asp Glu  Asn Gly Glu 
    1040                 1045                 1050             


Ile Leu  Trp Asp Lys Arg Tyr  Leu Glu Thr Val Lys  Lys Val Leu 
    1055                 1060                 1065             


Gly Tyr  Arg Gln Met Asn Ile  Val Lys Lys Thr Glu  Ile Gln Lys 
    1070                 1075                 1080             


Gly Glu  Phe Ser Asn Val Thr  Pro Asn Pro Lys Gly  Lys Ser Asn 
    1085                 1090                 1095             


Lys Leu  Ile Pro Arg Lys Lys  Asp Trp Asp Pro Ile  Lys Tyr Gly 
    1100                 1105                 1110             


Gly Phe  Asp Gly Ser Lys Met  Ala Tyr Ala Ile Ile  Ile Glu Tyr 
    1115                 1120                 1125             


Glu Lys  Gln Lys Arg Lys Val  Arg Ile Glu Lys Lys  Leu Ile Gln 
    1130                 1135                 1140             


Ile Asn  Ile Met Glu Arg Glu  Ala Phe Glu Lys Asp  Glu Lys Thr 
    1145                 1150                 1155             


Phe Leu  Glu Glu Lys Gly Tyr  His Gln Pro Lys Val  Leu Ile Lys 
    1160                 1165                 1170             


Val Pro  Lys Tyr Thr Leu Tyr  Glu Cys Lys Asn Gly  Arg Arg Arg 
    1175                 1180                 1185             


Met Leu  Gly Ser Ala Asn Glu  Ala His Lys Gly Asn  Gln Met Leu 
    1190                 1195                 1200             


Leu Pro  Asn His Leu Met Ala  Leu Leu Tyr His Ala  Glu Lys Tyr 
    1205                 1210                 1215             


Glu Ala  Ile Asp Gly Glu Ser  Leu Ala Tyr Ile Glu  Val His Arg 
    1220                 1225                 1230             


Ala Leu  Phe Asp Glu Leu Leu  Ala Tyr Ile Ser Glu  Phe Ala Arg 
    1235                 1240                 1245             


Lys Tyr  Thr Leu Ser Asn Asp  Arg Leu Asp Glu Ile  Asn Met Leu 
    1250                 1255                 1260             


Tyr Glu  Arg Asn Lys Asp Gly  Asp Val Lys Ser Ile  Ala Glu Ser 
    1265                 1270                 1275             


Phe Val  Ser Leu Lys Lys Phe  Asn Ala Phe Gly Val  His Gln Asp 
    1280                 1285                 1290             


Phe Ser  Phe Phe Gly Thr Lys  Ile Glu Arg Lys Arg  Asp Arg Lys 
    1295                 1300                 1305             


Leu Asn  Glu Leu Leu Asn Ser  Thr Ile Ile Tyr Gln  Ser Ile Thr 
    1310                 1315                 1320             


Gly Leu  Tyr Glu Ser Arg Lys  Arg Leu Asp Asn 
    1325                 1330                 


<210> 312
<211> 1334
<212> PRT
<213> Listeria monocytogenes


<220>
<223> Listeria monocytogenes FSL R2-503

<400> 312
Met Lys Asn Pro Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Leu Thr Asp Gln Tyr Asp Leu Val Lys Arg Lys Met 
            20                  25                  30          


Lys Val Ala Gly Asn Ser Asp Lys Lys Gln Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Asp Gly Gln Thr Ala Val Asp Arg Arg Met 
    50                  55                  60                  


Asn Arg Thr Ala Arg Arg Arg Ile Glu Arg Arg Arg Asn Arg Ile Ser 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Val Glu Met Ala Asn Ile Asp Ala Asn 
                85                  90                  95      


Phe Phe Cys Arg Leu Asn Asp Ser Phe Tyr Val Asp Ser Glu Lys Arg 
            100                 105                 110         


Asn Ser Arg His Pro Phe Phe Ala Thr Ile Glu Glu Glu Val Ala Tyr 
        115                 120                 125             


His Lys Asn Tyr Arg Thr Ile Tyr His Leu Arg Glu Glu Leu Val Asn 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Tyr Arg Gly Asn Phe Leu Ile Glu Gly Ala Leu Asp Thr 
                165                 170                 175     


Lys Asn Thr Ser Val Asp Glu Val Tyr Lys Gln Phe Ile Gln Thr Tyr 
            180                 185                 190         


Asn Gln Val Phe Met Ser Asn Ile Glu Glu Gly Ala Leu Ala Lys Val 
        195                 200                 205             


Glu Glu Asn Thr Glu Val Ala Ser Ile Leu Ala Gly Lys Phe Thr Arg 
    210                 215                 220                 


Arg Glu Lys Phe Glu Arg Ile Leu Arg Leu Tyr Pro Gly Glu Lys Ser 
225                 230                 235                 240 


Thr Gly Met Phe Ala Gln Phe Ile Ser Leu Ile Val Gly Asn Lys Gly 
                245                 250                 255     


Asn Phe Gln Lys Val Phe Asn Leu Val Glu Lys Thr Asp Ile Glu Cys 
            260                 265                 270         


Ala Lys Asp Ser Tyr Glu Glu Asp Leu Glu Ala Leu Leu Ala Ile Ile 
        275                 280                 285             


Gly Asp Glu Tyr Ala Glu Leu Phe Val Ala Ala Lys Asn Thr Tyr Asn 
    290                 295                 300                 


Ala Val Val Leu Ser Ser Ile Ile Thr Val Thr Ala Thr Glu Thr Asn 
305                 310                 315                 320 


Ala Lys Leu Ser Ala Ser Met Ile Glu Arg Phe Asp Ala His Glu Lys 
                325                 330                 335     


Glu Leu Gly Glu Leu Lys Ala Phe Ile Lys Leu His Leu Pro Lys Gln 
            340                 345                 350         


Tyr Gln Glu Ile Phe Asn Asn Ala Glu Ile Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Asp Gly Lys Thr Lys Gln Val Asp Phe Tyr Lys Tyr Leu Lys Thr 
    370                 375                 380                 


Thr Leu Glu Asn Val Glu Gly Ala Asp Tyr Phe Ile Thr Lys Ile Glu 
385                 390                 395                 400 


Glu Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Val Ile 
                405                 410                 415     


Pro His Gln Leu His Leu Glu Glu Leu Glu Ala Ile Leu His Gln Gln 
            420                 425                 430         


Ala Lys Tyr Tyr Pro Phe Leu Arg Glu Gly Tyr Asp Lys Ile Lys Ser 
        435                 440                 445             


Leu Val Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu Ala Asn Gly 
    450                 455                 460                 


Gln Ser Glu Phe Ala Trp Leu Thr Arg Lys Asp Asp Gly Glu Ile Arg 
465                 470                 475                 480 


Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser Ala Val Asp 
                485                 490                 495     


Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro Lys Glu Asn 
            500                 505                 510         


Val Leu Pro Lys His Ser Leu Cys Tyr Gln Lys Tyr Met Val Tyr Asn 
        515                 520                 525             


Glu Leu Thr Lys Ile Arg Tyr Ile Asp Asp Gln Gly Lys Thr Asn Tyr 
    530                 535                 540                 


Phe Ser Gly Arg Glu Lys Gln Gln Ile Phe Asn Asp Leu Phe Lys Gln 
545                 550                 555                 560 


Lys Arg Lys Val Lys Lys Lys Asp Leu Glu Leu Phe Leu Arg Asn Ile 
                565                 570                 575     


Asn His Ile Glu Ser Pro Thr Ile Glu Gly Leu Glu Asp Ser Phe Asn 
            580                 585                 590         


Ala Ser Tyr Ala Thr Tyr His Asp Leu Leu Lys Val Gly Leu Lys Gln 
        595                 600                 605             


Glu Ile Leu Asp Asn Pro Leu Asn Thr Glu Ile Leu Glu Asp Ile Val 
    610                 615                 620                 


Lys Ile Leu Thr Val Phe Glu Asp Lys Arg Met Ile Lys Glu Gln Leu 
625                 630                 635                 640 


Glu Gln Phe Ser Asp Val Leu Asp Gly Val Val Leu Lys Lys Leu Glu 
                645                 650                 655     


Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Val 
            660                 665                 670         


Gly Ile Arg Asp Lys Gln Ser His Leu Thr Ile Leu Asp Tyr Leu Met 
        675                 680                 685             


Asn Asp Asp Gly Leu Asn Arg Asn Leu Met Gln Leu Ile Asn Asp Ser 
    690                 695                 700                 


Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gln Val Ser Thr Thr 
705                 710                 715                 720 


Asp Lys Asp Leu Gln Ser Ile Val Ala Asp Leu Ala Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val 
            740                 745                 750         


Ser Ile Met Gly Tyr Pro Pro Gln Thr Ile Val Val Glu Met Ala Arg 
        755                 760                 765             


Glu Asn Gln Thr Thr Gly Lys Gly Lys Asn Asn Ser Lys Pro Arg Tyr 
    770                 775                 780                 


Lys Ser Leu Glu Lys Ala Ile Lys Asp Phe Gly Ser Gln Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asp Asn Gln Glu Leu Lys Asn Asn Arg Leu Tyr Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Ile Tyr Thr Gly Gln Glu Leu Asp 
            820                 825                 830         


Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Val Pro Gln Ser 
        835                 840                 845             


Phe Ile Thr Asp Asn Ser Ile Asp Asn Leu Val Leu Thr Ser Ser Ala 
    850                 855                 860                 


Gly Asn Arg Glu Lys Gly Gly Asp Val Pro Pro Leu Glu Ile Val Arg 
865                 870                 875                 880 


Lys Arg Lys Val Phe Trp Glu Lys Leu Tyr Gln Gly Asn Leu Met Ser 
                885                 890                 895     


Lys Arg Lys Phe Asp Tyr Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr 
            900                 905                 910         


Glu Ala Asp Lys Ala Arg Phe Ile His Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys Asn Val Ala Asn Ile Leu His Gln Arg Phe Asn Lys 
    930                 935                 940                 


Glu Thr Asp Asn His Gly Asn Thr Met Glu Gln Val Arg Ile Val Thr 
945                 950                 955                 960 


Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Lys Gln Phe Gln Leu Tyr 
                965                 970                 975     


Lys Val Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Gly Val Val Ala Asn Thr Leu  Leu Lys Val Tyr Pro  Gln Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Glu  Tyr His Gln Phe Asp  Trp Phe Lys 
    1010                 1015                 1020             


Ala Asn  Lys Ala Thr Ala Lys  Lys Gln Phe Tyr Thr  Asn Ile Met 
    1025                 1030                 1035             


Leu Phe  Phe Ala Gln Lys Glu  Arg Ile Ile Asp Glu  Asn Gly Glu 
    1040                 1045                 1050             


Ile Leu  Trp Asp Lys Lys Tyr  Leu Glu Thr Ile Lys  Lys Val Leu 
    1055                 1060                 1065             


Asp Tyr  Arg Gln Ile Asn Ile  Val Lys Lys Thr Glu  Ile Gln Lys 
    1070                 1075                 1080             


Gly Glu  Phe Ser Lys Ala Thr  Ile Lys Pro Lys Gly  Asn Ser Ser 
    1085                 1090                 1095             


Lys Leu  Ile Pro Arg Lys Glu  Asn Trp Asp Pro Val  Lys Tyr Gly 
    1100                 1105                 1110             


Gly Leu  Asp Ser Pro Asn Met  Ala Tyr Ala Val Ile  Ile Glu His 
    1115                 1120                 1125             


Ala Lys  Gly Lys Lys Lys Ile  Val Ile Glu Lys Lys  Leu Ile Gln 
    1130                 1135                 1140             


Ile Asn  Ile Met Glu Arg Lys  Met Phe Glu Lys Asp  Glu Glu Ala 
    1145                 1150                 1155             


Phe Leu  Glu Glu Lys Gly Tyr  His Gln Pro Lys Val  Leu Thr Lys 
    1160                 1165                 1170             


Leu Pro  Lys Tyr Thr Leu Tyr  Glu Cys Glu Lys Gly  Arg Arg Arg 
    1175                 1180                 1185             


Met Leu  Ser Ser Ala Asn Glu  Ala Gln Lys Gly Asn  Gln Leu Val 
    1190                 1195                 1200             


Leu Ser  Asn His Leu Val Ser  Leu Leu Tyr His Ala  Lys Asn Cys 
    1205                 1210                 1215             


Glu Ala  Ser Asp Gly Lys Ser  Leu Lys Tyr Ile Glu  Ala His Arg 
    1220                 1225                 1230             


Glu Thr  Phe Ser Glu Leu Leu  Ala Gln Val Ser Glu  Phe Ala Thr 
    1235                 1240                 1245             


Lys Tyr  Thr Leu Ala Asp Ala  Asn Leu Ser Lys Ile  Asn Asn Leu 
    1250                 1255                 1260             


Phe Glu  Gln Asn Lys Glu Gly  Asp Ile Lys Ala Ile  Ala Gln Ser 
    1265                 1270                 1275             


Phe Val  Asp Leu Met Ala Phe  Asn Ala Met Gly Ala  Pro Ala Ser 
    1280                 1285                 1290             


Phe Lys  Phe Phe Glu Ala Thr  Ile Asp Arg Lys Arg  Tyr Thr Asn 
    1295                 1300                 1305             


Leu Lys  Glu Leu Leu Ser Ser  Thr Ile Ile Tyr Gln  Ser Ile Thr 
    1310                 1315                 1320             


Gly Leu  Tyr Glu Ser Arg Lys  Arg Leu Asp Asp 
    1325                 1330                 


<210> 313
<211> 1334
<212> PRT
<213> Listeria monocytogenes


<220>
<223> Listeria monocytogenes serotype 1/2a str. F6854

<400> 313
Met Lys Asn Pro Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Leu Thr Asn Gln Tyr Asp Leu Val Lys Arg Lys Met 
            20                  25                  30          


Lys Val Ala Gly Asn Ser Asp Lys Lys Gln Ile Lys Lys Asn Phe Trp 
        35                  40                  45              


Gly Val Arg Leu Phe Asp Asp Gly Gln Thr Ala Val Asp Arg Arg Met 
    50                  55                  60                  


Asn Arg Thr Ala Arg Arg Arg Ile Glu Arg Arg Arg Asn Arg Ile Ser 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Val Glu Met Ala Asn Ile Asp Ala Asn 
                85                  90                  95      


Phe Phe Cys Arg Leu Asn Asp Ser Phe Tyr Val Asp Ser Glu Lys Arg 
            100                 105                 110         


Asn Ser Arg His Pro Phe Phe Ala Thr Ile Glu Glu Glu Val Ala Tyr 
        115                 120                 125             


His Asp Asn Tyr Arg Thr Ile Tyr His Leu Arg Glu Lys Leu Val Asn 
    130                 135                 140                 


Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Tyr Arg Gly Asn Phe Leu Ile Glu Gly Ala Leu Asp Thr 
                165                 170                 175     


Lys Asn Thr Ser Val Asp Glu Val Tyr Lys Gln Phe Ile Glu Thr Tyr 
            180                 185                 190         


Asn Gln Val Phe Met Ser Asn Ile Glu Glu Gly Ala Leu Ala Lys Val 
        195                 200                 205             


Glu Glu Asn Ile Glu Val Ala Asn Ile Leu Ala Gly Lys Phe Thr Arg 
    210                 215                 220                 


Arg Glu Lys Phe Glu Arg Ile Leu Gln Leu Tyr Pro Gly Glu Lys Ser 
225                 230                 235                 240 


Thr Gly Met Phe Ala Gln Phe Ile Ser Leu Ile Val Gly Ser Lys Gly 
                245                 250                 255     


Asn Phe Gln Lys Val Phe Asp Leu Ile Glu Lys Thr Asp Ile Glu Cys 
            260                 265                 270         


Ala Lys Asp Ser Tyr Glu Glu Asp Leu Glu Thr Leu Leu Ala Ile Ile 
        275                 280                 285             


Gly Asp Glu Tyr Ala Glu Leu Phe Val Ala Ala Lys Asn Thr Tyr Asn 
    290                 295                 300                 


Ala Val Val Leu Ser Ser Ile Ile Thr Val Thr Asp Thr Glu Thr Asn 
305                 310                 315                 320 


Ala Lys Leu Ser Ala Ser Met Ile Glu Arg Phe Asp Ala His Glu Lys 
                325                 330                 335     


Asp Leu Val Glu Leu Lys Ala Phe Ile Lys Leu Asn Leu Pro Lys Gln 
            340                 345                 350         


Tyr Glu Glu Ile Phe Ser Asn Ala Ala Ile Asp Gly Tyr Ala Gly Tyr 
        355                 360                 365             


Ile Asp Gly Lys Thr Lys Gln Val Asp Phe Tyr Lys Tyr Leu Lys Thr 
    370                 375                 380                 


Ile Leu Glu Asn Ile Glu Gly Ser Asp Tyr Phe Ile Ala Lys Ile Glu 
385                 390                 395                 400 


Glu Glu Asn Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ala Ile 
                405                 410                 415     


Pro His Gln Leu His Leu Glu Glu Leu Glu Ala Ile Ile His Gln Gln 
            420                 425                 430         


Ala Lys Tyr Tyr Pro Phe Leu Lys Glu Asp Tyr Asp Lys Ile Lys Ser 
        435                 440                 445             


Leu Val Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu Ala Asn Gly 
    450                 455                 460                 


Gln Ser Glu Phe Ala Trp Leu Thr Arg Lys Ala Asp Gly Glu Ile Arg 
465                 470                 475                 480 


Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser Ala Val Asp 
                485                 490                 495     


Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro Lys Glu Asn 
            500                 505                 510         


Val Leu Pro Lys His Ser Leu Cys Tyr Gln Lys Tyr Met Val Tyr Asn 
        515                 520                 525             


Glu Leu Thr Lys Ile Arg Tyr Ile Asp Asp Gln Gly Lys Thr Asn Tyr 
    530                 535                 540                 


Phe Ser Gly Arg Glu Lys Gln Gln Val Phe Asn Asp Leu Phe Lys Gln 
545                 550                 555                 560 


Lys Arg Lys Val Lys Lys Lys Asp Leu Glu Leu Phe Leu Arg Asn Ile 
                565                 570                 575     


Asn His Ile Glu Ser Pro Thr Ile Glu Gly Leu Glu Asp Ser Phe Asn 
            580                 585                 590         


Ala Ser Tyr Ala Thr Tyr His Asp Leu Leu Lys Val Gly Met Lys Gln 
        595                 600                 605             


Glu Ile Leu Asp Asn Pro Leu Asn Thr Glu Met Leu Glu Asp Ile Val 
    610                 615                 620                 


Lys Ile Leu Thr Val Phe Glu Asp Lys Pro Met Ile Lys Glu Gln Leu 
625                 630                 635                 640 


Gln Gln Phe Ser Asp Val Leu Asp Gly Gly Val Leu Lys Lys Leu Glu 
                645                 650                 655     


Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Val 
            660                 665                 670         


Gly Ile Arg Glu Lys Gln Ser His Leu Thr Ile Leu Asp Tyr Leu Met 
        675                 680                 685             


Asn Asp Asp Gly Leu Asn Arg Asn Leu Met Gln Leu Ile Asn Asp Ser 
    690                 695                 700                 


Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gln Val Ser Thr Thr 
705                 710                 715                 720 


Asp Lys Asp Leu Gln Ser Ile Val Ala Glu Leu Ala Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val 
            740                 745                 750         


Ser Ile Met Gly Tyr Pro Pro Gln Thr Ile Val Val Glu Met Ala Arg 
        755                 760                 765             


Glu Asn Gln Thr Thr Gly Lys Gly Lys Asn Asn Ser Lys Pro Arg Tyr 
    770                 775                 780                 


Lys Ser Leu Glu Lys Ala Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asp Asn Gln Glu Leu Lys Asn Asn Arg Leu Tyr Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Gln Glu Leu Asp 
            820                 825                 830         


Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Val Pro Gln Ser 
        835                 840                 845             


Phe Ile Thr Asp Asn Ser Ile Asp Asn Leu Val Leu Thr Ser Ser Ala 
    850                 855                 860                 


Gly Asn Arg Glu Lys Gly Gly Asp Val Pro Pro Leu Glu Ile Val Arg 
865                 870                 875                 880 


Lys Arg Lys Val Phe Trp Glu Lys Leu Tyr Gln Gly Asn Leu Met Ser 
                885                 890                 895     


Lys Arg Lys Phe Asp Tyr Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr 
            900                 905                 910         


Glu Ala Asp Lys Ala Arg Phe Ile His Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys Asn Val Ala Asn Ile Leu Tyr Gln Arg Phe Asn Lys 
    930                 935                 940                 


Glu Thr Asp Asn His Gly Asn Thr Met Glu Gln Val Arg Ile Val Thr 
945                 950                 955                 960 


Leu Lys Ser Ala Leu Val Ser Gln Phe Arg Lys Gln Phe Gln Leu Tyr 
                965                 970                 975     


Lys Val Arg Glu Val Asn Gly Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Gly Val Val Ala Asn Thr Leu  Leu Lys Val Tyr Pro  Gln Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Glu  Tyr His Gln Phe Asp  Trp Phe Lys 
    1010                 1015                 1020             


Ala Asn  Lys Ala Thr Ala Lys  Lys Gln Phe Tyr Thr  Asn Ile Met 
    1025                 1030                 1035             


Leu Phe  Phe Ala Gln Lys Glu  Arg Ile Ile Asp Glu  Asn Gly Glu 
    1040                 1045                 1050             


Ile Leu  Trp Asp Lys Lys Tyr  Leu Glu Thr Ile Lys  Lys Val Leu 
    1055                 1060                 1065             


Asp Tyr  Arg Gln Met Asn Ile  Val Lys Lys Thr Glu  Ile Gln Lys 
    1070                 1075                 1080             


Gly Glu  Phe Ser Lys Ala Thr  Ile Lys Pro Lys Gly  Asn Ser Ser 
    1085                 1090                 1095             


Lys Leu  Ile Pro Arg Lys Glu  Asn Trp Asp Pro Met  Lys Tyr Gly 
    1100                 1105                 1110             


Gly Leu  Asp Ser Pro Asn Met  Ala Tyr Ala Val Ile  Ile Glu His 
    1115                 1120                 1125             


Ala Lys  Gly Lys Lys Lys Ile  Val Ile Glu Lys Lys  Leu Ile Gln 
    1130                 1135                 1140             


Ile Asn  Ile Met Glu Arg Lys  Met Phe Glu Lys Asp  Glu Glu Ala 
    1145                 1150                 1155             


Phe Leu  Glu Glu Lys Gly Tyr  Arg His Pro Lys Val  Leu Thr Lys 
    1160                 1165                 1170             


Leu Pro  Lys Tyr Thr Leu Tyr  Glu Cys Glu Lys Gly  Arg Arg Arg 
    1175                 1180                 1185             


Met Leu  Ala Ser Ala Asn Glu  Ala Gln Lys Gly Asn  Gln Leu Val 
    1190                 1195                 1200             


Leu Ser  Asn His Leu Val Ser  Leu Leu Tyr His Ala  Lys Asn Cys 
    1205                 1210                 1215             


Glu Ala  Ser Asp Gly Lys Ser  Leu Lys Tyr Ile Glu  Ala His Arg 
    1220                 1225                 1230             


Glu Thr  Phe Ser Glu Leu Leu  Ala Gln Val Ser Glu  Phe Ala Thr 
    1235                 1240                 1245             


Arg Tyr  Thr Leu Ala Asp Ala  Asn Leu Ser Lys Ile  Asn Asn Leu 
    1250                 1255                 1260             


Phe Glu  Gln Asn Lys Glu Gly  Asp Ile Lys Ala Ile  Ala Gln Ser 
    1265                 1270                 1275             


Phe Val  Asp Leu Met Ala Phe  Asn Ala Met Gly Ala  Pro Ala Ser 
    1280                 1285                 1290             


Phe Lys  Phe Phe Glu Ala Thr  Ile Asp Arg Lys Arg  Tyr Thr Asn 
    1295                 1300                 1305             


Leu Lys  Glu Leu Leu Ser Ser  Thr Ile Ile Tyr Gln  Ser Ile Thr 
    1310                 1315                 1320             


Gly Leu  Tyr Glu Ser Arg Lys  Arg Leu Asp Asp 
    1325                 1330                 


<210> 314
<211> 1087
<212> PRT
<213> Listeriaceae bacterium


<220>
<223> Listeriaceae bacterium TTU M1-001

<400> 314
Met Lys Lys Leu Val Leu Gly Leu Asp Ile Gly Val Ala Ser Val Gly 
1               5                   10                  15      


Trp Gly Ile Ile Asp Ala Glu Asn Gly Asp Val Val Asp Thr Gly Val 
            20                  25                  30          


Arg Leu Phe Ser Ser Arg Asp Ala Ser Glu Asn Glu Ser Arg Arg Thr 
        35                  40                  45              


Ser Arg Gln Ser Arg Arg Leu Ser Arg Arg Lys Lys His Arg Arg Glu 
    50                  55                  60                  


Arg Ile Lys Gln Leu Leu Leu Ala His Asp Met Asp Ile Cys Asp Ile 
65                  70                  75                  80  


Val Asn Glu Asn Pro Tyr Glu Leu Arg Val Lys Gly Leu Asn Glu Lys 
                85                  90                  95      


Leu Glu Val Ser Glu Ile Tyr Val Ala Leu Thr His Leu Ala Lys Arg 
            100                 105                 110         


Arg Gly Val Ser Tyr Leu Asp Asp Val Val Glu Glu Gly Gly Thr Ile 
        115                 120                 125             


Lys Ser Glu His Leu Asn Lys Asn Met Glu Glu Ile Lys Ser Gly Lys 
    130                 135                 140                 


Met Pro Cys Glu Ile Gln Leu Glu Arg Phe Glu Lys Tyr Gly Gln Val 
145                 150                 155                 160 


Arg Gly Met Ile Glu Ile Asn Gln Asp Thr Glu Glu Ser Ser Phe Leu 
                165                 170                 175     


Val Asn Ile Phe Arg Thr Ser Asp Tyr Ile Lys Glu Ala Lys Thr Ile 
            180                 185                 190         


Leu Ala Thr Gln Gln Lys Phe His Lys Gln Ile Thr Asn Glu Phe Ile 
        195                 200                 205             


Asp Glu Tyr Ile His Ile Met Ala Ser Lys Arg Asp Tyr Phe Ile Gly 
    210                 215                 220                 


Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Val Tyr Arg Thr Asn 
225                 230                 235                 240 


Gly Asp Thr Trp Asp Asn Leu Phe Glu Ile Leu Ile Gly Lys Cys Ser 
                245                 250                 255     


Val Phe Pro Glu Glu Thr Arg Ala Ala Arg Ser Ser Tyr Val Ala Gln 
            260                 265                 270         


Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Lys Ile Ser Asn Leu 
        275                 280                 285             


Glu Ser Gly Lys Leu Ser Ala Ser Gln Lys His Asp Ile Val Glu Lys 
    290                 295                 300                 


Val Lys Asn Ser Lys Lys Phe Gly Thr Lys Asp Leu Leu Lys Tyr Ile 
305                 310                 315                 320 


Ala Ser Val Cys Glu Cys Lys Ile Glu Asp Ile Gly Gly Cys Arg Val 
                325                 330                 335     


Asp Lys Asn Arg Lys Pro Ile Met His Thr Phe Glu Asn Tyr Arg Lys 
            340                 345                 350         


Val His Asn Ala Leu Asn Glu Ala Gly Val Asp Leu Arg Leu Ser Glu 
        355                 360                 365             


Thr Asp Tyr Asp Glu Leu Met Lys Ile Met Thr Leu Asn Ser Glu Thr 
    370                 375                 380                 


Leu Glu Ile Lys Lys Gln Cys Lys Glu Lys Leu Pro Gln Leu Thr Glu 
385                 390                 395                 400 


Asp Tyr Leu Asn Val Cys Leu Val Leu Asn Lys Lys Gly Ala Phe Ser 
                405                 410                 415     


Gly Trp His Ala Leu Ser Leu Lys Ala Met Lys Leu Met Met Pro Glu 
            420                 425                 430         


Leu Tyr Gly Thr Ser Lys Asn Gln Met Gln Ile Ile His Thr Met Gln 
        435                 440                 445             


Leu Gly Lys Ala Tyr Leu Lys Pro Leu Asn Gln Gln Lys Tyr Leu Asn 
    450                 455                 460                 


Ser Glu Ala Ile Leu Glu Glu Ile Tyr Asn Pro Ile Ala Ala Arg Ser 
465                 470                 475                 480 


Ile Arg Gln Thr Ile Lys Val Thr Asn Ala Ile Leu Lys Lys Tyr Gly 
                485                 490                 495     


His Leu Asp Ser Val Ile Ile Glu Met Pro Arg Asp Tyr Gln Thr Ser 
            500                 505                 510         


Glu Asp Glu Arg Lys Met Ile Glu Lys Met Gln Lys Glu Asn Glu Lys 
        515                 520                 525             


Glu Lys Lys Ala Ala Leu Lys Arg Ala Arg Glu Glu Tyr Pro Phe Pro 
    530                 535                 540                 


Asp Glu Ala Phe Arg Asn His Lys Glu Leu Ala Thr Lys Leu Arg Leu 
545                 550                 555                 560 


Trp Tyr Gln Gln Asp Gln Phe Cys Val Tyr Ser Gly Arg Lys Ile Ser 
                565                 570                 575     


Val Val Asp Leu Val Arg Asn Pro Asn Gln Phe Glu Ile Asp His Ile 
            580                 585                 590         


Ile Pro Gln Ser Val Ser Leu Asp Asp Ser Leu Asn Asn Lys Val Leu 
        595                 600                 605             


Cys Phe Ser Glu Glu Asn Gln Lys Lys Gly Gln Gln Thr Pro Phe Tyr 
    610                 615                 620                 


Tyr His Lys Gly Lys Ser Gly Asn Trp Thr Tyr Glu Gln Tyr Lys Leu 
625                 630                 635                 640 


Phe Val Glu Lys Leu Phe Asp Lys Lys Lys Ile Ser Asn Lys Lys Arg 
                645                 650                 655     


Glu Leu Leu Leu Phe Glu Glu Asp Ile Asn Lys Trp Asp Val Arg Arg 
            660                 665                 670         


Gly Phe Ile Ala Arg Asn Leu Val Asp Thr Arg Tyr Ala Ser Arg Val 
        675                 680                 685             


Ile Leu Asn Ser Tyr Gln Gln Tyr Phe Gly Asn His Glu Met Gly Thr 
    690                 695                 700                 


Lys Val Lys Val Val Arg Gly Lys Phe Thr Ser Gln Leu Arg Lys Lys 
705                 710                 715                 720 


Trp Arg Ile Phe Lys Asp Arg Asn Glu Ser His Ser His His Ala Ile 
                725                 730                 735     


Asp Ala Leu Ile Val Ala Ala Thr Ala Asn Leu Arg Leu Trp Lys Lys 
            740                 745                 750         


Asn Thr Leu Gly Val Ser Asp Glu Gly Lys Val Tyr Asp Lys Glu Thr 
        755                 760                 765             


Gly Glu Ile Leu Pro Phe Glu Lys Leu Thr Glu Ser Glu Tyr Asn Glu 
    770                 775                 780                 


Met Met Asn Lys Glu Pro Tyr Leu Asn Phe Lys Thr Lys Leu Gln Asn 
785                 790                 795                 800 


Ile Glu Thr Lys Val Lys Tyr Ser Tyr Arg Val Ser Lys Lys Val Asn 
                805                 810                 815     


Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ser Thr Arg Glu Arg Asp Gly 
            820                 825                 830         


Ile Asp Tyr Ile Val Gly Lys Ile Lys Asn Ile Tyr Asp Val Lys Thr 
        835                 840                 845             


Tyr Lys Asp Gln Phe Leu Lys Arg Tyr Lys Lys Asn Lys Glu Gln Phe 
    850                 855                 860                 


Leu Met Tyr Gln His Asp Pro Gln Thr Phe Ala Ile Leu Glu Asn Ile 
865                 870                 875                 880 


Met Ala Thr Tyr Gln Asp Ala Glu Asn Pro Phe Leu Ala Tyr Lys Lys 
                885                 890                 895     


Glu Tyr Gly Val Ile Arg Lys Tyr Ser Lys Lys Gly Gly Gly Ser Pro 
            900                 905                 910         


Val Thr Ser Leu Lys Phe Ile Asp Lys Val Leu Gly Gln Lys Ile Asp 
        915                 920                 925             


Leu Thr Ala Lys Asn Gln Ala Ala Leu Pro Lys Asn Lys Lys Val Val 
    930                 935                 940                 


Leu Gln Ser Ile Thr Pro Tyr Arg Ala Asp Val Tyr Tyr Asp Glu Ile 
945                 950                 955                 960 


Asp Lys Arg Tyr His Leu Ile Gly Val Lys Tyr Ser Leu Phe Ser Phe 
                965                 970                 975     


Ser Lys Gln Gly Tyr Val Ile Asn Pro Ile Ala Tyr Gln Lys Leu Leu 
            980                 985                 990         


Glu Lys Glu Gln Ile His Ser Glu  Met Lys Phe Cys Phe  Ser Leu Tyr 
        995                 1000                 1005             


Arg Glu  Asp Ile Ile Glu Phe  Gly Glu Asp Pro Asp  Ser Leu Thr 
    1010                 1015                 1020             


Arg Tyr  Arg Phe Trp Ser Lys  Asn Glu Ser Gly Lys  Asn Lys Ile 
    1025                 1030                 1035             


Glu Val  Lys Pro Ile Glu Lys  Pro Asn Phe Glu Lys  Gln Thr Val 
    1040                 1045                 1050             


Leu Thr  Ile Thr Lys Lys Ile  Lys Ile Leu Asn Lys  Tyr Gln Thr 
    1055                 1060                 1065             


Asp Val  Leu Gly Asn Ser Phe  Lys Ala Gln Glu Glu  Lys Asp Pro 
    1070                 1075                 1080             


Arg Asn  Ile Glu 
    1085         


<210> 315
<211> 1345
<212> PRT
<213> Marinilabilia sp.


<220>
<223> Marinilabilia sp. AK2

<400> 315
Met Lys Lys Ile Leu Gly Leu Asp Leu Gly Thr Thr Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ile Lys Glu Pro Glu Lys Asp Val Val Gly Ser Glu Ile Val 
            20                  25                  30          


Asp Met Gly Val Arg Ile Val Ala Leu Ser Ser Asp Glu Glu Asn Asp 
        35                  40                  45              


Phe Ala Lys Gly Asn Thr Ile Ser Ile Asn Ala Asp Arg Thr Leu Lys 
    50                  55                  60                  


Arg Gly Ala Arg Arg Asn Leu Gln Arg Phe Lys Leu Arg Arg Asp Ala 
65                  70                  75                  80  


Leu Leu Glu Ile Phe Lys Glu Met Lys Leu Ile Pro Ser Asn Phe Lys 
                85                  90                  95      


Tyr Ala Glu Asp Gly Pro Ser Ser Thr Phe Ser Thr Leu Lys Leu Arg 
            100                 105                 110         


Asp Lys Ala Ala Lys Glu Lys Ile Glu Leu Asp Asp Leu Val Lys Val 
        115                 120                 125             


Leu Leu Gln Ile Asn Lys Lys Arg Gly Tyr Arg Ser Ser Arg Lys Ala 
    130                 135                 140                 


Lys Ser Glu Glu Asp Asp Gly Ser Ala Ile Asp Ser Met Gly Ile Ala 
145                 150                 155                 160 


Lys Glu Leu Tyr Glu Asn Asp Leu Thr Pro Gly Gln Trp Val Phe Glu 
                165                 170                 175     


Ala Leu Gln Lys Gly Arg Lys Asn Val Pro Asp Phe Tyr Arg Ser Asp 
            180                 185                 190         


Leu Gln Glu Glu Phe Lys Lys Ile Val Asn Tyr Gln Ser Glu Phe Tyr 
        195                 200                 205             


Pro Asp Val Leu Asn Ser Ser Phe Val Glu Asp Trp Met Gly Lys Ala 
    210                 215                 220                 


Ser Thr Pro Thr Lys Gln Tyr Phe Asn Lys Lys Gly Val His Leu Ala 
225                 230                 235                 240 


Glu Asn Lys Gly Lys Arg Glu Glu Arg Arg Leu Gln Glu Tyr Asn Trp 
                245                 250                 255     


Arg Ala Val Ala Val Asn Ser Lys Ile Asp Leu Ser Glu Ile Ala Leu 
            260                 265                 270         


Ile Leu Ser Gln Ile Asn Ser Gln Ile Ser Asn Ser Ser Gly Tyr Leu 
        275                 280                 285             


Gly Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Lys Asn Gln Thr 
    290                 295                 300                 


Val Gly Gln Tyr Leu Tyr Gln Gln Ile Lys Ile Asn Pro His Thr Arg 
305                 310                 315                 320 


Leu Lys Gly Gln Val Phe Tyr Arg Gln Asp Tyr Leu Asp Glu Phe Glu 
                325                 330                 335     


Lys Ile Trp Ser Val Gln Ser Gly Phe His Pro Gln Leu Asn Asp Ala 
            340                 345                 350         


Leu Lys Lys Glu Ile Arg Asp Ile Thr Ile Phe Phe Gln Arg Arg Leu 
        355                 360                 365             


Lys Ser Gln Lys His Leu Ile Ser Asn Cys Glu Phe Glu Asp Tyr His 
    370                 375                 380                 


Lys Val Val Pro Lys Ser His Pro Ile Phe Gln Glu Phe Arg Ile Trp 
385                 390                 395                 400 


Gln Asn Leu Asn Asn Leu Thr Leu Ile Lys Lys Asp Asn Leu Asn Glu 
                405                 410                 415     


Lys Ser Glu Leu Ala Leu Glu Asp Lys Ile Ala Leu Ala Asn Glu Leu 
            420                 425                 430         


Ala Phe Lys Arg Glu Gln Ser Val Lys Asp Ala Leu Asn Ile Leu Gly 
        435                 440                 445             


Leu Lys Ser Ser Glu Trp Glu Phe Asn Phe Thr Lys Ile Glu Gly Asn 
    450                 455                 460                 


Arg Thr Asn His Ala Phe Phe Glu Ala Phe Ala Lys Ile Ile Glu Ile 
465                 470                 475                 480 


Glu Asp Gly Glu Pro Leu Asp Leu Gly Asn Leu Lys Ala Asp Asp Ile 
                485                 490                 495     


Leu Asp Gln Phe Ser Glu Ala Phe Leu Arg Ile Gly Ile Asp Pro Gly 
            500                 505                 510         


Leu Leu Gln Val Asn Asn Asp Ile Glu Gly Pro Asn Tyr Glu Lys Gln 
        515                 520                 525             


Pro Tyr Ile Gln Phe Trp His Leu Leu Tyr Ser Ser Glu Asp Asp Gln 
    530                 535                 540                 


Lys Leu Lys Gln Asn Leu Ile Lys Lys Phe Gly Phe Lys Pro Asp His 
545                 550                 555                 560 


Ala Lys Ile Leu Ala Ser Ile Ser Leu Gln Asp Asp His Ala Ser Leu 
                565                 570                 575     


Ser Ser Arg Ala Ile Lys Lys Ile Leu Pro His Leu Gln Ser Gly Leu 
            580                 585                 590         


Ile Tyr Asp Lys Ala Cys Thr Tyr Ala Gly Tyr Asn His Ser Ser Ser 
        595                 600                 605             


Phe Thr Lys Glu Glu Asn Glu Lys Arg Glu Leu Ser Ser Glu Leu Asp 
    610                 615                 620                 


Leu Leu Lys Lys Asn Ser Leu Arg Asn Pro Val Val Glu Lys Ile Leu 
625                 630                 635                 640 


Asn Gln Met Ile Asn Val Val Asn Ala Ile Leu Lys Asp Pro Asn Leu 
                645                 650                 655     


Gly Lys Pro Asp Glu Ile Arg Val Glu Met Ala Arg Glu Leu Lys Ala 
            660                 665                 670         


Asn Ala Glu Gln Arg Lys Asn Met Thr Ser Asn Ile Ala Ser Ala Thr 
        675                 680                 685             


Arg Asp His Glu Lys Tyr Arg Glu Ile Leu Lys Lys Glu Phe Gly Leu 
    690                 695                 700                 


Lys Arg Val Thr Lys Asn Asp Leu Leu Arg Tyr Lys Leu Trp Leu Glu 
705                 710                 715                 720 


Thr Asp Gly Ile Ser Leu Tyr Thr Gly Lys Pro Ile Glu Ala Ser Lys 
                725                 730                 735     


Leu Phe Ser Lys Glu Tyr Asp Ile Glu His Ile Ile Pro Lys Thr Arg 
            740                 745                 750         


Leu Phe Asp Asp Ser Phe Ser Asn Lys Thr Ile Cys Glu Arg Gln Leu 
        755                 760                 765             


Asn Ile Asp Lys Ala Asn Val Thr Ala Phe Ser Phe Leu Gln Asn Lys 
    770                 775                 780                 


Leu Ser Gly Asp Glu Phe Glu Gln Tyr Gln Ser Arg Val Lys Ser Leu 
785                 790                 795                 800 


Phe Gly Lys Leu Ser Lys Ala Lys Ile Gln Lys Leu Leu Met Ala Asn 
                805                 810                 815     


Asp Lys Ile Pro Glu Asp Phe Ile Ala Arg Gln Leu Gln Glu Thr Arg 
            820                 825                 830         


Tyr Ile Ser Lys Lys Ala Lys Glu Ile Leu Phe Glu Ile Thr Arg Arg 
        835                 840                 845             


Val Ser Val Thr Thr Gly Thr Ile Thr Asp Lys Leu Arg Glu Asp Trp 
    850                 855                 860                 


Gly Leu Val Glu Ile Met Lys Glu Leu Asn Trp Glu Lys Tyr Asp Lys 
865                 870                 875                 880 


Leu Gly Leu Thr Tyr Thr Ile Glu Gly Lys His Gly Glu Arg Leu Asn 
                885                 890                 895     


Lys Ile Lys Asp Trp Ser Lys Arg Asn Asp His Arg His His Ala Met 
            900                 905                 910         


Asp Ala Leu Thr Val Ala Leu Thr Lys Pro Ala Tyr Ile Gln Tyr Leu 
        915                 920                 925             


Asn Asn Leu Asn Ala Lys Glu Leu Asn Gly Lys Lys Ser Thr Glu Ile 
    930                 935                 940                 


Phe Ala Ile Glu Gln Lys Tyr Leu Lys Arg Glu Asn Gly Lys Leu Cys 
945                 950                 955                 960 


Phe Ile Pro Pro Val Glu Asn Ile Arg Thr Glu Ala Lys Lys His Leu 
                965                 970                 975     


Ser Lys Val Leu Ile Ser Tyr Lys Ala Lys Asn Lys Val Val Thr Ile 
            980                 985                 990         


Asn Lys Asn Arg Thr Asn Lys Lys  Ala Gly Phe Asn Glu  Gln Ile Ala 
        995                 1000                 1005             


Leu Thr  Pro Arg Gly Gln Leu  His Lys Glu Thr Val  Tyr Gly Lys 
    1010                 1015                 1020             


Ala Phe  His Tyr Ser Thr Lys  Phe Glu Lys Ile Gly  Ala Ser Phe 
    1025                 1030                 1035             


Asp Val  Gln Lys Ile Asn Ala  Val Ala Lys Lys Glu  Glu Arg Glu 
    1040                 1045                 1050             


Ala Leu  Leu Lys Arg Leu Ala  Glu Asn Gly Asp Asp  Pro Lys Lys 
    1055                 1060                 1065             


Ala Phe  Thr Gly Lys Asn Ser  Leu Ser Lys Met Pro  Ile Tyr Leu 
    1070                 1075                 1080             


Asp Leu  Lys Arg Asn Ile Lys  Leu Pro Glu Lys Val  Lys Thr Val 
    1085                 1090                 1095             


Val Leu  Glu Gln Asn Tyr Thr  Ile Arg Lys Asn Ile  Asp Pro Asp 
    1100                 1105                 1110             


Leu Lys  Leu Asp Lys Val Ile  Asp Val Gly Val Lys  Arg Ile Leu 
    1115                 1120                 1125             


Glu Asn  Arg Leu Lys Glu Phe  Gly Gly Asn Ala Lys  Leu Ala Leu 
    1130                 1135                 1140             


Ser Asn  Leu Asp Glu Asn Pro  Ile Trp Leu Asn Lys  Glu Lys Gly 
    1145                 1150                 1155             


Ile Thr  Ile Lys Arg Val Lys  Ile Ser Gly Val Ser  Asn Val Glu 
    1160                 1165                 1170             


Ser Leu  His Val Lys Lys Asp  His Phe Gly Glu Pro  Ile Leu Asp 
    1175                 1180                 1185             


Gln Val  Gly Asn Glu Ile Pro  Val Asp Phe Val Ser  Thr Gly Asn 
    1190                 1195                 1200             


Asn His  His Val Ala Ile Tyr  Glu Asp Glu Lys Gly  Asn Leu Gln 
    1205                 1210                 1215             


Glu Glu  Val Val Ser Phe Phe  Glu Ala Val Val Arg  Gln Asn Gln 
    1220                 1225                 1230             


Gly Leu  Pro Ile Ile Asn Lys  Asn His Ser Leu Gly  Trp Lys Phe 
    1235                 1240                 1245             


Leu Phe  Thr Leu Lys Gln Asn  Glu Tyr Phe Val Phe  Pro Ser Asp 
    1250                 1255                 1260             


Asp Phe  Asp Pro Thr Asp Val  Asp Leu Met Asp Glu  Glu Asn Tyr 
    1265                 1270                 1275             


His Leu  Ile Ser Pro Asn Leu  Phe Arg Val Gln Lys  Phe Thr Thr 
    1280                 1285                 1290             


Lys Asp  Tyr Phe Phe Arg His  His Leu Glu Thr Thr  Val Glu Asp 
    1295                 1300                 1305             


Lys Ser  Glu Leu Lys Gly Val  Ser Phe Lys Arg Leu  Gly Leu Pro 
    1310                 1315                 1320             


Gly Leu  Asn Cys Ile Lys Lys  Ile Arg Ile Asn His  Leu Gly Lys 
    1325                 1330                 1335             


Ile Ile  Gln Val Gly Glu Tyr  
    1340                 1345 


<210> 316
<211> 1352
<212> PRT
<213> Megasphaera sp.


<220>
<223> Megasphaera sp. UPII 135-E

<400> 316
Met Lys Lys Arg Asn Arg Glu Glu Tyr Tyr Val Gly Leu Asp Ile Gly 
1               5                   10                  15      


Thr Ser Ser Val Gly Trp Ala Val Ala Thr Pro Asp Tyr Arg Ile Pro 
            20                  25                  30          


Lys Phe Arg Gly His Lys Met Trp Gly Ser Arg Leu Phe Ala Glu Gly 
        35                  40                  45              


Lys Arg Ala Ala Glu Arg Arg Gln Phe Arg Thr Asn Arg Arg Arg Leu 
    50                  55                  60                  


Ala Arg Arg Arg Asp Arg Leu Gln Ile Leu Glu Glu Leu Phe Ala Glu 
65                  70                  75                  80  


Glu Met Ala Lys Val Asp Asn Thr Phe Phe Met Arg Leu Lys Glu Ser 
                85                  90                  95      


Lys Phe Phe Leu Glu Asp Lys Thr Val Lys Glu Lys His Ile Leu Phe 
            100                 105                 110         


Ser Thr Asp Lys Phe Asp Ala Asp Arg Phe Tyr Lys Asp Asn Pro Thr 
        115                 120                 125             


Ile Tyr His Val Arg Lys Arg Leu Met Glu Glu Glu Pro Gln Asp Ile 
    130                 135                 140                 


Arg Glu Leu Phe Leu Ala Val His His Ile Leu Lys Tyr Arg Gly His 
145                 150                 155                 160 


Phe Leu Phe Ala Gly Ser Leu Glu Gln Asn Gly Ala Ser Ile Glu Glu 
                165                 170                 175     


Leu Val Arg Thr Leu Leu Gly Lys Gln Gly Leu Ala Ile Leu Asp Asp 
            180                 185                 190         


Thr Ile Asp Ser Asn Glu Met Val Asn Ile Leu Lys Asn Thr Gly Glu 
        195                 200                 205             


Thr Lys Ser Asp Arg Lys Lys Asp Val Gln Glu Leu Trp Asn Pro Leu 
    210                 215                 220                 


Lys Asp Lys Val Lys Lys Ala Gln Ala Ala Glu Met Ala Gly Leu Val 
225                 230                 235                 240 


Leu Gly Leu Lys Ser Asp Ile Ser Lys Leu Phe Ala Asn Ser Asp Tyr 
                245                 250                 255     


Lys Asp Leu Asp Ser Ser Ile Lys Asn Ile Asn Phe Ser Ser Gly Asp 
            260                 265                 270         


Tyr Glu Glu Lys Arg Asp Asp Tyr Ala Asn Ser Ile Gly Asp Asp Ile 
        275                 280                 285             


Val Leu Leu Asp Thr Met Lys Ala Leu Tyr Asp Thr Leu Ile Leu Ser 
    290                 295                 300                 


Gln Ile Leu Gln Gly Lys Arg Ser Ile Ser Ala Ala Lys Val Glu Asp 
305                 310                 315                 320 


Tyr Asn Thr His Lys Glu Gln Leu Arg Ala Leu Lys Ala Ile Leu Lys 
                325                 330                 335     


Pro His Lys Arg Leu Tyr Asn Glu Met Phe Arg Glu Asn Asn Lys Lys 
            340                 345                 350         


Asp Leu Ser Asn Tyr Val Ala Tyr Ile Ser Ser Tyr Ser Glu Gly Lys 
        355                 360                 365             


Arg Val Asn Arg Glu Gly Phe Tyr Lys Tyr Val Gln Ala Val Leu Lys 
    370                 375                 380                 


Gln Val Asp Asp Ser Asp Ser Lys Gln Ala Ile Leu Glu Ala Ile Arg 
385                 390                 395                 400 


Leu Glu Thr Phe Leu Pro Leu Leu Arg Val Lys Asp Asn Ala Val Ile 
                405                 410                 415     


Pro His Gln Ile His Gln Ala Glu Leu Glu Ala Ile Leu Glu Thr Ala 
            420                 425                 430         


Arg Lys Lys Tyr Asn Phe Leu Asn Asp Val Ser Asp Gly Val Ser Val 
        435                 440                 445             


Lys Asp Lys Ile Ile Gln Leu Phe Thr Phe Arg Ile Pro Tyr Tyr Val 
    450                 455                 460                 


Gly Pro Leu Asn Pro His Ser Gly Glu Thr Val Ala Asp Arg Lys Gln 
465                 470                 475                 480 


Gly Thr Gly Trp Val Val Arg Lys Gln Arg Gly Lys Val Tyr Pro Trp 
                485                 490                 495     


Asn Phe Ala Asp Met Val Asp Val Lys Ala Ser Ala Glu Ala Phe Ile 
            500                 505                 510         


Thr Asn Leu Thr Asn Lys Cys Thr Tyr Leu Ile Gly Glu Asp Val Leu 
        515                 520                 525             


Pro Lys Arg Ser Leu Leu Tyr Ser Glu Phe Met Leu Leu Asn Glu Leu 
    530                 535                 540                 


Asn Met Ile Lys Tyr Asp Gly His Glu Leu Pro Val Ala Ile Lys Gln 
545                 550                 555                 560 


Leu Tyr Ile Glu Gln Val Phe Lys Gln Glu His Lys Lys Gln Thr Lys 
                565                 570                 575     


Gly Arg Val Leu Asp Phe Leu Lys Arg Asn Gly Leu Ile Thr Gly Ser 
            580                 585                 590         


Ala Thr Ala Val Ile Thr Gly Met Asp Asp Ala Ile Lys Gly Asp Leu 
        595                 600                 605             


Gln Ser Tyr Arg Asp Met Val Arg Ile Phe Gly Ala Gly Phe Asp His 
    610                 615                 620                 


Ser Met Ala Glu Arg Ile Ile Arg Trp Val Thr Leu Phe Gly Glu Ala 
625                 630                 635                 640 


Lys Asp Ile Leu Glu Asn Lys Ile Arg Glu Val Tyr Gly Asn Ser Ile 
                645                 650                 655     


Ser Asp Ser Gln Met Arg Ala Ile Lys Lys Leu Lys Tyr Ala Asp Trp 
            660                 665                 670         


Gly Arg Leu Ser Gln Ala Phe Leu Ile Ala Val Lys Gly Cys Asp Lys 
        675                 680                 685             


Ser Gly Val Glu Arg Asn Ile Ile Thr Cys Leu Arg Ala Ser Ser Gln 
    690                 695                 700                 


Asn Leu Met Glu Ile Leu Ser Asp Gln Gly Thr Tyr Ile Lys Gln Ile 
705                 710                 715                 720 


Lys Ala Trp Asn His Gln His Thr Thr Asn Met Met Asp Thr Leu Asp 
                725                 730                 735     


Tyr Gln Leu Val Asp Asp Leu Tyr Val Ala Pro Ser Val Lys Arg Ser 
            740                 745                 750         


Ile Trp Gln Ser Leu Cys Ile Val Glu Glu Leu Val Lys Ile Met Gly 
        755                 760                 765             


Gln Ala Pro Lys Lys Ile Phe Val Glu Val Thr Arg Thr Lys Gln Ala 
    770                 775                 780                 


Glu Lys Thr Lys Lys Asp Ser Arg Lys Lys Arg Leu Val Glu Leu Tyr 
785                 790                 795                 800 


Thr Ala Ile Gly Lys Glu Gly Ala Ala Trp Lys Lys Glu Ile Glu Ala 
                805                 810                 815     


His Gln Ala Gly Asp Phe Arg Arg Lys Lys Leu Tyr Leu Tyr Tyr Thr 
            820                 825                 830         


Gln Met Gly Arg Cys Met Tyr Ser Asn Glu Pro Ile Ala Met Asp Ala 
        835                 840                 845             


Leu Phe Thr Ser Ala Tyr Asp Ile Asp His Ile Tyr Pro Gln Ser Leu 
    850                 855                 860                 


Thr Lys Asp Gly Ser Trp Asp Asn Leu Val Leu Val Lys Ser Gln Leu 
865                 870                 875                 880 


Asn Lys Glu Lys Ser Asp Gln Tyr Pro Leu Arg Pro Ala Ile Arg Glu 
                885                 890                 895     


Lys Asn Lys Ala His Trp Gln Tyr Leu Cys Arg Ala Gly Phe Ile Ser 
            900                 905                 910         


Glu Lys Lys Tyr Glu Arg Leu Met Arg Thr Thr Glu Leu Thr Ala Glu 
        915                 920                 925             


Glu Leu Ser Gly Phe Ile Ala Arg Gln Leu Val Glu Thr Ser Gln Ala 
    930                 935                 940                 


Thr Lys Ala Val Thr Gly Leu Leu Glu Arg Ile Tyr Thr Asn Thr Glu 
945                 950                 955                 960 


Ile Cys Phe Val Lys Ala Glu Thr Val Ser Gln Phe Arg His Gln His 
                965                 970                 975     


Asn Phe Ile Lys Ile Arg Glu Leu Asn Asn Tyr His His Ala Lys Asp 
            980                 985                 990         


Ala Tyr Leu Asn Ile Val Val Gly  Asn Val Tyr His Glu  Lys Phe Thr 
        995                 1000                 1005             


Lys Asn  Pro Trp Glu Phe Ile  Ala Arg Ser Thr Glu  Arg Arg Pro 
    1010                 1015                 1020             


Tyr Asn  Leu Asn Arg Met Tyr  Asp Phe Asp Leu Leu  Lys Gln Gly 
    1025                 1030                 1035             


Arg Val  Ile Trp Gln Val Pro  Lys Ser Leu Glu Thr  Val Gln Ala 
    1040                 1045                 1050             


Met Met  Lys Ser Asn Asp Val  Arg Ile Thr Lys Lys  Leu Leu Val 
    1055                 1060                 1065             


Gln Lys  Gly Glu Leu Tyr Asp  Ala Thr Ile Thr Lys  Ala His Lys 
    1070                 1075                 1080             


Ala Lys  Glu Gly Thr Tyr Phe  Pro Leu Lys Gly Ala  Asp Ala Arg 
    1085                 1090                 1095             


Leu Arg  Asp Val His Arg Tyr  Gly Gly Tyr Glu Lys  Ile Lys Ile 
    1100                 1105                 1110             


Ala Tyr  Tyr Ser Val Phe Ser  Cys Arg Glu Lys Ala  Ser Asn Thr 
    1115                 1120                 1125             


Ile His  Thr Leu Ile Ile Pro  Ile Pro Val Tyr Lys  Ala Gly Leu 
    1130                 1135                 1140             


Leu Gln  Thr Glu Ala Asp Leu  Thr Ala Tyr Ala Trp  Gln Thr Lys 
    1145                 1150                 1155             


Gln Lys  Thr Lys Pro Ile Lys  Asp Ile Tyr Ser Ala  Ile Thr Pro 
    1160                 1165                 1170             


Ile Tyr  Lys Lys Leu Cys Ile  Asn Thr Val Val Lys  Ile Asp Gly 
    1175                 1180                 1185             


Phe Lys  Tyr Phe Leu Gly Gly  Lys Thr Gly Asp Tyr  Met Trp Leu 
    1190                 1195                 1200             


Asp Pro  Ala Ile Pro Val Val  Leu Asp Glu Gln Ala  Ala Ala Tyr 
    1205                 1210                 1215             


Leu Lys  Ala Ile Ser Lys Val  Gly Arg Ala Asp Asp  Val Glu Asn 
    1220                 1225                 1230             


Thr Ala  Gln Ala Ile Asp Leu  Ile Thr Ala Glu Ala  Asn Glu Ala 
    1235                 1240                 1245             


Phe Tyr  Asp Val Leu Leu Lys  Lys Met Glu Ala Lys  Ile Phe Ala 
    1250                 1255                 1260             


Lys Ala  Tyr Gln Thr Ile Val  Glu Lys Leu Ala Ser  Glu Thr Ala 
    1265                 1270                 1275             


Arg Glu  Arg Phe Arg Glu Leu  Ser Ile Gly Ala Gln  Cys Ser Cys 
    1280                 1285                 1290             


Leu Leu  Glu Ile Leu Asn Leu  Leu Ala Asn Asn Lys  Thr Thr Phe 
    1295                 1300                 1305             


Thr Phe  Phe Lys Asp Lys Met  Gly Val Thr Met Ser  Arg Arg Lys 
    1310                 1315                 1320             


Gln Pro  Met Asp Leu Thr Lys  Leu Glu Glu Cys Ile  Val Tyr Glu 
    1325                 1330                 1335             


Thr Ser  Ile Thr Gly Leu Tyr  Glu Lys Ala Val Ser  Leu Leu 
    1340                 1345                 1350         


<210> 317
<211> 1080
<212> PRT
<213> Methylocystis sp.


<220>
<223> Methylocystis sp. ATCC 49242

<400> 317
Met Arg Val Leu Gly Leu Asp Gly Gly Ile Ala Ser Ile Gly Trp Ala 
1               5                   10                  15      


Leu Ile Glu Ile Phe Glu Asp His Glu Pro Ser Asp Gly Arg Ile Ile 
            20                  25                  30          


Asp Thr Gly Ala Trp Met Phe Asp Ala Pro Glu Glu Lys Ser Gln Thr 
        35                  40                  45              


Gly Thr Lys Leu Lys Ser Glu Leu Arg Arg Ile Phe Arg Gly Gln Arg 
    50                  55                  60                  


Arg Val Ile Arg Arg Arg Arg Gln Arg Met Asn Glu Val Arg Arg Ile 
65                  70                  75                  80  


Leu His Arg His Gly Leu Leu Ser Ser Asp Asn Arg Asp Ala Leu Lys 
                85                  90                  95      


Gln Pro Gly Leu Asp Pro Trp Lys Ile Arg Ala Glu Gly Ile Asp Arg 
            100                 105                 110         


Leu Leu Ser Pro Ile Glu Phe Ala Val Ala Leu Gly His Ile Ala Arg 
        115                 120                 125             


His Arg Gly Phe Lys Ser Asn Ser Lys Gly Ala Lys Thr Ser Asp Leu 
    130                 135                 140                 


Asp Ala Glu Ser Ser Arg Met Lys Lys Ala Val Gly Glu Thr Arg Glu 
145                 150                 155                 160 


Lys Leu Ala Arg Phe Gly Ser Pro Ala Lys Leu Leu Val Glu Asp Glu 
                165                 170                 175     


Gly Phe Val Leu Arg Gln Thr Lys Leu Lys Ser Gly Ala Leu Glu Thr 
            180                 185                 190         


Val Arg Arg Phe Arg Asn Arg Asp Gly Asp Tyr Ser Arg Ser Leu Leu 
        195                 200                 205             


Arg Asp Asp Leu Ala Ala Glu Val Arg Ala Leu Phe Arg Ala Gln Ala 
    210                 215                 220                 


Arg Leu Gln Ser Thr Phe Ala Lys Val Glu Leu Glu Ala Glu Phe Thr 
225                 230                 235                 240 


Gln Ala Ala Phe Phe Gln Arg Pro Leu Gln Asp Ser Glu Arg Leu Val 
                245                 250                 255     


Gly Pro Cys Pro Phe Glu Pro Ala Glu Lys Arg Ser Pro Lys Arg Gly 
            260                 265                 270         


Tyr Ser Phe Glu Leu Phe Arg Phe Leu Ser Arg Leu Asn His Leu Thr 
        275                 280                 285             


Leu Arg Glu Gly Ser Glu Glu Arg Thr Leu Thr Val Glu Glu Leu Arg 
    290                 295                 300                 


Thr Ala Ala Ala Asp Phe Gly Gly Val Ala Lys Phe Thr Phe Ser Thr 
305                 310                 315                 320 


Leu Arg Lys Arg Leu Ala Leu Pro Asp Ile Ala Ile Phe Val Gly Ile 
                325                 330                 335     


Lys Ala Asp Asp Glu Lys Lys Leu Asp Val Val Ala Arg Ser Gly Glu 
            340                 345                 350         


Ala Ala Thr Gly Thr Ala Arg Leu Arg Arg Val Val Ile Asp Ala Leu 
        355                 360                 365             


Gly Glu Leu Ala Trp Gly Ala Leu Ile Ser Ala Pro Glu Arg Leu Asp 
    370                 375                 380                 


Lys Ile Thr Glu Ile Ile Thr Phe Arg Ser Asp Leu Asp Arg Ile Arg 
385                 390                 395                 400 


Ala Gly Leu Ile Glu Ala Gly Phe Asp Thr Pro Leu Ile Glu Ala Ile 
                405                 410                 415     


Val Arg Ala Ala Ala Asp Gly Lys Leu Asp Ala Phe Thr Gly Val Gly 
            420                 425                 430         


His Ile Ser Ala Lys Ala Ala Arg Asn Ile Ile Pro Gly Leu Met Arg 
        435                 440                 445             


Gly Met Thr Tyr Asp Lys Ala Cys Ala Ala Ala Gly Tyr Asp His Thr 
    450                 455                 460                 


Ala Ser Arg Glu Arg Asp Ala Phe Asp Val Gly Met His Gly Lys Glu 
465                 470                 475                 480 


Ala Leu Lys Lys Ile Leu Gln Glu Glu Arg Ile Ser Arg Glu Leu Val 
                485                 490                 495     


Gly Ser Pro Ser Ala Arg Lys Ala Leu Ile Glu Ala Val Lys Gln Val 
            500                 505                 510         


Lys Ala Ile Ile Glu Lys Tyr Gly Val Pro Asp Arg Ile His Val Glu 
        515                 520                 525             


Leu Ala Arg Asp Val Gly Lys Ser Ile Glu Glu Arg Arg Asp Ile His 
    530                 535                 540                 


Phe Gly Ile Glu Lys Arg Ser Arg Gln Lys Asp Lys Leu Arg Glu Leu 
545                 550                 555                 560 


Phe Gly Lys Glu Val Gly His Leu Pro Gln Asp Gly Glu Arg Gly Lys 
                565                 570                 575     


Glu Glu Leu Leu Arg Phe Glu Leu Trp Asn Glu Gln Met Gly Arg Cys 
            580                 585                 590         


Leu Tyr Thr Asp Glu Tyr Ile Asn Pro Lys Gln Leu Val Ala Ser Asp 
        595                 600                 605             


Asn Ser Val Gln Val Asp His Ile Leu Pro Trp Ser Arg Phe Gly Asp 
    610                 615                 620                 


Asp Ser Tyr Leu Asn Lys Thr Leu Cys Thr Ala Lys Ala Asn Gln Asp 
625                 630                 635                 640 


Lys Lys Gly Arg Thr Pro Tyr Glu Trp Phe Arg Ala Asp Lys Pro Glu 
                645                 650                 655     


Ala Glu Trp Asp Ala Phe Val Ala Arg Val Glu Ser Ile Gln Phe Met 
            660                 665                 670         


Lys Gly Leu Lys Lys Arg Asn Tyr Lys Leu Lys Asn Ala Glu Glu Ala 
        675                 680                 685             


Ala Glu Lys Phe Arg Ser Arg Asn Leu Asn Asp Thr Arg Trp Thr Cys 
    690                 695                 700                 


Arg Leu Leu Ala Glu Ala Leu Lys Gln Leu Tyr Pro Lys Gly Glu Lys 
705                 710                 715                 720 


Asp Lys Asp Gly Lys Glu Arg Arg Arg Val Phe Thr Arg Pro Gly Ala 
                725                 730                 735     


Leu Thr Asn Arg Leu Arg Arg Ala Trp Ser Leu Gln Arg Arg Lys Lys 
            740                 745                 750         


Ser Glu Lys Gly Glu Arg Ile Ala Asp Asp Arg His His Ala Leu Asp 
        755                 760                 765             


Ala Ile Ile Val Ala Ala Thr Thr Glu Ser Leu Leu Ile Arg Ala Thr 
    770                 775                 780                 


Arg Glu Val Gln Asp Ile Glu Arg Lys Gly Leu His Tyr Asp Leu Thr 
785                 790                 795                 800 


Lys Asn Ile Thr Gln Pro Trp Pro Gly Phe Ala Asp Glu Ala Leu Asp 
                805                 810                 815     


Ala Val Glu Lys Val Phe Val Ala Arg Ala Glu Arg Arg Arg Ala Arg 
            820                 825                 830         


Gly Lys Ala His Asp Ala Thr Ile Arg His Ile Ala Val Arg Asp Asp 
        835                 840                 845             


Glu Ala Lys Val Tyr Glu Arg Lys Lys Val Gly Asp Ile Lys Leu Gly 
    850                 855                 860                 


Asp Leu Ile Arg Val Lys Asp Ala Glu Arg Asn Ala Pro Leu Ile Glu 
865                 870                 875                 880 


Asn Leu Arg Lys Trp Ile Glu Ala Gly Ser Pro Arg Asp Asn Pro Pro 
                885                 890                 895     


Leu Ser Pro Lys Gly Asp Pro Val Ser Lys Val Arg Leu Val Thr Lys 
            900                 905                 910         


Asn Lys Val Asn Ile Thr Leu Asp Thr Gly Asn Pro Glu Arg Leu Ala 
        915                 920                 925             


Thr Val Asp Arg Gly Glu Met Ala Arg Val Asp Val Phe Arg Lys Ala 
    930                 935                 940                 


Asn Arg Lys Gly Lys Tyr Glu Tyr Tyr Leu Val Pro Ile Tyr Pro His 
945                 950                 955                 960 


Glu Ile Ala Thr Met Glu Thr Pro Pro Met Arg Ala Val Gln Gly Gly 
                965                 970                 975     


Gly Asp Asp Asp Lys Trp Pro Glu Ile Asp Ser Thr Phe Glu Phe Leu 
            980                 985                 990         


Trp Ser Ile Asn Gln Leu Ser Leu  Leu Glu Leu Thr Lys  Pro Asp Gly 
        995                 1000                 1005             


Glu Val  Ile Arg Ser Tyr Phe  Arg Ser Leu Asp Arg  Asn Thr Gly 
    1010                 1015                 1020             


Ala Leu  Thr Val Ser Gly Ile  Ala Asn Ser Thr Ala  Thr Arg Lys 
    1025                 1030                 1035             


Gly Ile  Gly Thr Arg Thr Leu  Ile Asp Phe Lys Lys  Leu His Val 
    1040                 1045                 1050             


Asp Arg  Leu Gly Gln Ile Phe  Glu Val Glu Arg Glu  Leu Arg Thr 
    1055                 1060                 1065             


Trp Arg  Gly Glu Thr Trp Arg  Gly Lys Asp Cys Ile  
    1070                 1075                 1080 


<210> 318
<211> 1082
<212> PRT
<213> Methylosinus trichosporium


<220>
<223> Methylosinus trichosporium OB3b

<400> 318
Met Arg Val Leu Gly Leu Asp Ala Gly Ile Ala Ser Leu Gly Trp Ala 
1               5                   10                  15      


Leu Ile Glu Ile Glu Glu Ser Asn Arg Gly Glu Leu Ser Gln Gly Thr 
            20                  25                  30          


Ile Ile Gly Ala Gly Thr Trp Met Phe Asp Ala Pro Glu Glu Lys Thr 
        35                  40                  45              


Gln Ala Gly Ala Lys Leu Lys Ser Glu Gln Arg Arg Thr Phe Arg Gly 
    50                  55                  60                  


Gln Arg Arg Val Val Arg Arg Arg Arg Gln Arg Met Asn Glu Val Arg 
65                  70                  75                  80  


Arg Ile Leu His Ser His Gly Leu Leu Pro Ser Ser Asp Arg Asp Ala 
                85                  90                  95      


Leu Lys Gln Pro Gly Leu Asp Pro Trp Arg Ile Arg Ala Glu Ala Leu 
            100                 105                 110         


Asp Arg Leu Leu Gly Pro Val Glu Leu Ala Val Ala Leu Gly His Ile 
        115                 120                 125             


Ala Arg His Arg Gly Phe Lys Ser Asn Ser Lys Gly Ala Lys Thr Asn 
    130                 135                 140                 


Asp Pro Ala Asp Asp Thr Ser Lys Met Lys Arg Ala Val Asn Glu Thr 
145                 150                 155                 160 


Arg Glu Lys Leu Ala Arg Phe Gly Ser Ala Ala Lys Met Leu Val Glu 
                165                 170                 175     


Asp Glu Ser Phe Val Leu Arg Gln Thr Pro Thr Lys Asn Gly Ala Ser 
            180                 185                 190         


Glu Ile Val Arg Arg Phe Arg Asn Arg Glu Gly Asp Tyr Ser Arg Ser 
        195                 200                 205             


Leu Leu Arg Asp Asp Leu Ala Ala Glu Met Arg Ala Leu Phe Thr Ala 
    210                 215                 220                 


Gln Ala Arg Phe Gln Ser Ala Ile Ala Thr Ala Asp Leu Gln Thr Ala 
225                 230                 235                 240 


Phe Thr Lys Ala Ala Phe Phe Gln Arg Pro Leu Gln Asp Ser Glu Lys 
                245                 250                 255     


Leu Val Gly Pro Cys Pro Phe Glu Val Asp Glu Lys Arg Ala Pro Lys 
            260                 265                 270         


Arg Gly Tyr Ser Phe Glu Leu Phe Arg Phe Leu Ser Arg Leu Asn His 
        275                 280                 285             


Val Thr Leu Arg Asp Gly Lys Gln Glu Arg Thr Leu Thr Arg Asp Glu 
    290                 295                 300                 


Leu Ala Leu Ala Ala Ala Asp Phe Gly Ala Ala Ala Lys Val Ser Phe 
305                 310                 315                 320 


Thr Ala Leu Arg Lys Lys Leu Lys Leu Pro Glu Thr Thr Val Phe Val 
                325                 330                 335     


Gly Val Lys Ala Asp Glu Glu Ser Lys Leu Asp Val Val Ala Arg Ser 
            340                 345                 350         


Gly Lys Ala Ala Glu Gly Thr Ala Arg Leu Arg Ser Val Ile Val Asp 
        355                 360                 365             


Ala Leu Gly Glu Leu Ala Trp Gly Ala Leu Leu Cys Ser Pro Glu Lys 
    370                 375                 380                 


Leu Asp Lys Ile Ala Glu Val Ile Ser Phe Arg Ser Asp Ile Gly Arg 
385                 390                 395                 400 


Ile Ser Glu Gly Leu Ala Gln Ala Gly Cys Asn Ala Pro Leu Val Asp 
                405                 410                 415     


Ala Leu Thr Ala Ala Ala Ser Asp Gly Arg Phe Asp Pro Phe Thr Gly 
            420                 425                 430         


Ala Gly His Ile Ser Ser Lys Ala Ala Arg Asn Ile Leu Ser Gly Leu 
        435                 440                 445             


Arg Gln Gly Met Thr Tyr Asp Lys Ala Cys Cys Ala Ala Asp Tyr Asp 
    450                 455                 460                 


His Thr Ala Ser Arg Glu Arg Gly Ala Phe Asp Val Gly Gly His Gly 
465                 470                 475                 480 


Arg Glu Ala Leu Lys Arg Ile Leu Gln Glu Glu Arg Ile Ser Arg Glu 
                485                 490                 495     


Leu Val Gly Ser Pro Thr Ala Arg Lys Ala Leu Ile Glu Ser Ile Lys 
            500                 505                 510         


Gln Val Lys Ala Ile Val Glu Arg Tyr Gly Val Pro Asp Arg Ile His 
        515                 520                 525             


Val Glu Leu Ala Arg Asp Val Gly Lys Ser Ile Glu Glu Arg Glu Glu 
    530                 535                 540                 


Ile Thr Arg Gly Ile Glu Lys Arg Asn Arg Gln Lys Asp Lys Leu Arg 
545                 550                 555                 560 


Gly Leu Phe Glu Lys Glu Val Gly Arg Pro Pro Gln Asp Gly Ala Arg 
                565                 570                 575     


Gly Lys Glu Glu Leu Leu Arg Phe Glu Leu Trp Ser Glu Gln Met Gly 
            580                 585                 590         


Arg Cys Leu Tyr Thr Asp Asp Tyr Ile Ser Pro Ser Gln Leu Val Ala 
        595                 600                 605             


Thr Asp Asp Ala Val Gln Val Asp His Ile Leu Pro Trp Ser Arg Phe 
    610                 615                 620                 


Ala Asp Asp Ser Tyr Ala Asn Lys Thr Leu Cys Met Ala Lys Ala Asn 
625                 630                 635                 640 


Gln Asp Lys Lys Gly Arg Thr Pro Tyr Glu Trp Phe Lys Ala Glu Lys 
                645                 650                 655     


Thr Asp Thr Glu Trp Asp Ala Phe Ile Val Arg Val Glu Ala Leu Ala 
            660                 665                 670         


Asp Met Lys Gly Phe Lys Lys Arg Asn Tyr Lys Leu Arg Asn Ala Glu 
        675                 680                 685             


Glu Ala Ala Ala Lys Phe Arg Asn Arg Asn Leu Asn Asp Thr Arg Trp 
    690                 695                 700                 


Ala Cys Arg Leu Leu Ala Glu Ala Leu Lys Gln Leu Tyr Pro Lys Gly 
705                 710                 715                 720 


Glu Lys Asp Lys Asp Gly Lys Glu Arg Arg Arg Val Phe Ser Arg Pro 
                725                 730                 735     


Gly Ala Leu Thr Asp Arg Leu Arg Arg Ala Trp Gly Leu Gln Trp Met 
            740                 745                 750         


Lys Lys Ser Thr Lys Gly Asp Arg Ile Pro Asp Asp Arg His His Ala 
        755                 760                 765             


Leu Asp Ala Ile Val Ile Ala Ala Thr Thr Glu Ser Leu Leu Gln Arg 
    770                 775                 780                 


Ala Thr Arg Glu Val Gln Glu Ile Glu Asp Lys Gly Leu His Tyr Asp 
785                 790                 795                 800 


Leu Val Lys Asn Val Thr Pro Pro Trp Pro Gly Phe Arg Glu Gln Ala 
                805                 810                 815     


Val Glu Ala Val Glu Lys Val Phe Val Ala Arg Ala Glu Arg Arg Arg 
            820                 825                 830         


Ala Arg Gly Lys Ala His Asp Ala Thr Ile Arg His Ile Ala Val Arg 
        835                 840                 845             


Glu Gly Glu Gln Arg Val Tyr Glu Arg Arg Lys Val Ala Glu Leu Lys 
    850                 855                 860                 


Leu Ala Asp Leu Asp Arg Val Lys Asp Ala Glu Arg Asn Ala Arg Leu 
865                 870                 875                 880 


Ile Glu Lys Leu Arg Asn Trp Ile Glu Ala Gly Ser Pro Lys Asp Asp 
                885                 890                 895     


Pro Pro Leu Ser Pro Lys Gly Asp Pro Ile Phe Lys Val Arg Leu Val 
            900                 905                 910         


Thr Lys Ser Lys Val Asn Ile Ala Leu Asp Thr Gly Asn Pro Lys Arg 
        915                 920                 925             


Pro Gly Thr Val Asp Arg Gly Glu Met Ala Arg Val Asp Val Phe Arg 
    930                 935                 940                 


Lys Ala Ser Lys Lys Gly Lys Tyr Glu Tyr Tyr Leu Val Pro Ile Tyr 
945                 950                 955                 960 


Pro His Asp Ile Ala Thr Met Lys Thr Pro Pro Ile Arg Ala Val Gln 
                965                 970                 975     


Ala Tyr Lys Pro Glu Asp Glu Trp Pro Glu Met Asp Ser Ser Tyr Glu 
            980                 985                 990         


Phe Cys Trp Ser Leu Val Pro Met  Thr Tyr Leu Gln Val  Ile Ser Ser 
        995                 1000                 1005             


Lys Gly  Glu Ile Phe Glu Gly  Tyr Tyr Arg Gly Met  Asn Arg Ser 
    1010                 1015                 1020             


Val Gly  Ala Ile Gln Leu Ser  Ala His Ser Asn Ser  Ser Asp Val 
    1025                 1030                 1035             


Val Gln  Gly Ile Gly Ala Arg  Thr Leu Thr Glu Phe  Lys Lys Phe 
    1040                 1045                 1050             


Asn Val  Asp Arg Phe Gly Arg  Lys His Glu Val Glu  Arg Glu Leu 
    1055                 1060                 1065             


Arg Thr  Trp Arg Gly Glu Thr  Trp Arg Gly Lys Ala  Tyr Ile 
    1070                 1075                 1080         


<210> 319
<211> 1123
<212> PRT
<213> Mobiluncus curtisii


<220>
<223> Mobiluncus curtisii subsp. holmesii ATCC 35242

<400> 319
Met Phe Val Tyr Leu Asn Ser Pro Arg Gly Phe Gly Pro Ala Thr Phe 
1               5                   10                  15      


Leu Thr Asp Leu Pro His Phe Cys Ile Ile Phe Gly Asn Asn Asp Phe 
            20                  25                  30          


Met Asp Asn Arg Lys Tyr His Val Gly Ile Asp Val Gly Thr Asn Ser 
        35                  40                  45              


Val Gly Phe Ala Ala Val Glu Val Gly Asp Ser Gly Ser Pro Ile Arg 
    50                  55                  60                  


Phe Leu Asn Thr Met Val Val Ile His Asp Ser Gly Val Asp Pro Glu 
65                  70                  75                  80  


Gln Lys Lys Tyr Ala Ile Thr Arg Leu Ala Ser Ala Gly Thr Ala Arg 
                85                  90                  95      


Arg Thr Arg Arg Leu Tyr Arg Thr Arg Arg Gln Arg Leu Arg Glu Leu 
            100                 105                 110         


Asp Asp Phe Ile Ser Asn Glu Leu Gly Tyr Pro Leu Val Asn Leu Glu 
        115                 120                 125             


Asn Phe Ala Asp Pro Tyr Glu Pro Trp Lys Val Arg Ala Asp Leu Ala 
    130                 135                 140                 


Thr Ile Lys Leu Pro Ala Asp Glu Leu Pro Glu Ala Met Ser Ile Ala 
145                 150                 155                 160 


Leu Arg His Met Ala Arg His Arg Gly Trp Arg Ser Pro Tyr Gln Arg 
                165                 170                 175     


Val Glu Ala Leu His Leu His Ala Glu Ile Ser Glu Glu Phe Ser Ala 
            180                 185                 190         


Leu Lys Lys Arg Val Met Glu Lys Thr Gly Asp Val Phe Ser Asp Asp 
        195                 200                 205             


Ala Thr Pro Ala Glu Val Leu Val Asp Leu Met Gly Arg Gln Lys Ile 
    210                 215                 220                 


Arg Gly Ala Asp Gly Met Leu Ser Gly Lys Leu Arg Gln Ser Asp Asn 
225                 230                 235                 240 


Ala Asn Glu Leu Arg Lys Ile Ala Ser Val Gln Gly Ile Asp Asp Glu 
                245                 250                 255     


Thr Leu Asn Arg Ile Ile Asp Arg Val Phe Phe Ser Arg Ser Pro Lys 
            260                 265                 270         


Gly Lys Ala Ser Glu Arg Val Gly Met Asp Ala Leu Pro Gly Gln Gly 
        275                 280                 285             


Ser Lys Pro Arg Ala Leu Lys Ala Met Pro Ser Phe Gln Lys Phe Arg 
    290                 295                 300                 


Ile Val Ser Val Ile Cys Asn Leu Arg Ile Lys Asp Ser Gly Asp Asp 
305                 310                 315                 320 


Asn Arg Pro Leu Ser Met Glu Glu Lys Glu Gln Leu Ile Gly Tyr Leu 
                325                 330                 335     


Met Ser Ser Thr Thr Asp Asp His Val Thr Trp Thr Asp Val Ala Glu 
            340                 345                 350         


Leu Leu His Val Lys Arg Ser Asn Leu Gln Gly Thr Ala Lys Glu Gly 
        355                 360                 365             


Pro Asp Gly Glu Arg Pro Tyr Thr Arg Pro Pro Val Asn Ser Ala Trp 
    370                 375                 380                 


Ser Lys Ile Lys Asp Ser Lys Ile Lys Ser Leu Val Ala Leu Trp Lys 
385                 390                 395                 400 


Thr Gly Asp Val Asp Val Gln Ser Ala Ile Val Glu Ala Leu Ser Asn 
                405                 410                 415     


Ala Ser Val Leu Glu Asp Ala Arg Pro Gly Ala Asp Ile Val Val Ala 
            420                 425                 430         


Tyr Leu Glu Ser Leu Asp Asp Lys Glu Leu Glu Ser Leu Asp Lys Val 
        435                 440                 445             


Gly Leu Pro Ala Gly Arg Ala Ser Tyr Ser Glu Asp Ser Leu Glu Arg 
    450                 455                 460                 


Leu Thr Glu Arg Met Leu Gln Asp Asp Cys Asp Leu Phe Glu Ala Arg 
465                 470                 475                 480 


Lys Arg Glu Phe Gly Val Ser Asp Asp Trp Lys Pro Pro Ala Asp Pro 
                485                 490                 495     


Ile Tyr Ala Pro Val Gly Asn Pro Gly Val Asp Arg Val Leu Lys Ile 
            500                 505                 510         


Val Asn Arg Leu Leu Met Ala Ala Glu Arg Glu Trp Gly Ala Pro Thr 
        515                 520                 525             


Gln Ile Asn Ile Glu His Val Arg Ser Gly Phe Ser Ser Glu Leu Met 
    530                 535                 540                 


Gln Arg Glu Phe Glu Arg Glu Asn Glu Arg Arg Arg Ala Gln Asn Glu 
545                 550                 555                 560 


Glu Ala Val Lys Ala Ile Leu Thr Glu Lys Gly Gly Asn Ser His Val 
                565                 570                 575     


Ser Lys Tyr Asp Ile Ile Arg Tyr Tyr Ala Val Lys Arg Gln Asn Cys 
            580                 585                 590         


Gln Cys Leu Tyr Cys Gly Thr Pro Ile Thr Phe Ser Asp Cys Glu Leu 
        595                 600                 605             


Asp His Ile Val Pro Arg Lys Gly Val Gly Ser Thr Asn Ser Arg Val 
    610                 615                 620                 


Asn Leu Ala Ala Ala Cys Arg Ser Cys Asn Arg Asp Lys Ser Asn Leu 
625                 630                 635                 640 


Pro Phe Ala Val Trp Ala Gly Lys Thr Ser Asn Phe Asp Val Ser Ile 
                645                 650                 655     


Asp Gly Ala Val Ser Arg Val Lys Gln Trp Gln Arg Ser Gln Asn Glu 
            660                 665                 670         


Gly Ala Arg Glu Phe Arg Ala Phe Gln Asn Glu Val Ile Ser Arg Leu 
        675                 680                 685             


Leu Lys Thr Thr Glu Asp Pro Glu Ile Asp Ser Arg Ser Leu Glu Ser 
    690                 695                 700                 


Val Ala Trp Met Ala Arg Glu Leu His His Arg Val Glu Tyr Tyr Phe 
705                 710                 715                 720 


Gln Ser Lys Gly Ala Gln Thr Gln Val Ser Val Tyr Arg Gly Ala Val 
                725                 730                 735     


Thr Ala Gln Ala Arg Lys Ser Ser Gly Leu Glu Asp Lys Val Lys Met 
            740                 745                 750         


Ile Gly Gly Gly Gly Lys Thr Arg Leu Asp Arg Arg His His Ala Met 
        755                 760                 765             


Asp Ala Ala Thr Ile Ala Leu Met Thr Pro Gly Ile Ser Thr Thr Leu 
    770                 775                 780                 


Ser Glu Lys Asn Asn Leu Arg Asp Ala Gln Lys Phe Thr Gly Gln Ser 
785                 790                 795                 800 


Glu Thr Trp Lys Asp Tyr Cys Gly Arg Thr Glu Thr Ala Arg Glu His 
                805                 810                 815     


Phe Ala Val Trp Lys Ser Asn Met Glu Arg Leu Thr Asp Leu Phe Asn 
            820                 825                 830         


Asp Lys Leu Glu Asn Asp Ala Ile Pro Val Val Gln Pro Leu Arg Leu 
        835                 840                 845             


Arg Leu Ser Asp Ser Lys Ala His Asp Asp Gly Ile Gly Lys Leu Asp 
    850                 855                 860                 


Ser Lys Lys Leu Gly Ser Val Trp Ser Leu Ala Asp Ile Asp Arg Ala 
865                 870                 875                 880 


Ala Thr Pro Gln Ile Trp Thr Ala Leu Thr Arg Cys Asp Asp Phe Asp 
                885                 890                 895     


Pro Thr Lys Gly Leu Pro Glu Asn Ala Asn Arg Val Ile Arg Ala Gln 
            900                 905                 910         


Gly Val Lys Tyr Glu Ser Glu Asp Asn Ile Pro Val Phe Pro Ser Asn 
        915                 920                 925             


Val Ala Ala Ile Ala Val Arg Asp Gly Tyr Ala Glu Ile Gly Ser Thr 
    930                 935                 940                 


Ile His His Ala Arg Ile Tyr Arg Ile Asp Asp Gly Lys Lys Ile Phe 
945                 950                 955                 960 


Tyr Ser Met Ile Arg Val Phe Ala Val Asp Leu Leu Lys His Gln Ala 
                965                 970                 975     


Glu Asp Leu Phe Thr Val Lys Leu Pro Pro Ser Ala Ile Ser Ile Arg 
            980                 985                 990         


Thr Cys Glu Asp Ser Leu Arg Arg  Ala Leu Ser Asn Gly  Thr Ala Glu 
        995                 1000                 1005             


Tyr Leu  Gly Trp Leu Val Pro  Gly Asp Glu Ile Ile  Val Asp Thr 
    1010                 1015                 1020             


Ser Asp  Lys Ala Phe His Thr  Gly Gln Ile Gly Asp  Leu Leu Arg 
    1025                 1030                 1035             


Asn Phe  Pro Val Asn Ser Phe  Arg Leu Thr Gly Phe  Pro Ser Asn 
    1040                 1045                 1050             


Ser Arg  Leu Arg Leu Lys Pro  Val Leu Leu Ala Gly  Glu Gly Leu 
    1055                 1060                 1065             


Arg Asp  Asp Ala Glu Asp Ser  Ile Lys Lys Ile Leu  Ser Gly Gln 
    1070                 1075                 1080             


Gly Trp  Arg Pro Ala Ile Asn  Val Leu Phe Ser Lys  Gly Lys Pro 
    1085                 1090                 1095             


Arg Ile  Val Arg Arg Asn Ser  Leu Gly Ile Glu Arg  Pro Ser Ser 
    1100                 1105                 1110             


Asn Asn  Gly Leu Pro Phe Ser  Trp Glu Ala 
    1115                 1120             


<210> 320
<211> 1091
<212> PRT
<213> Mobiluncus mulieris


<220>
<223> Mobiluncus mulieris 28-1

<400> 320
Met Asp Ser Arg Lys Tyr Arg Val Gly Ile Asp Val Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Phe Ala Ala Val Glu Glu Asp Asp Ser Gly Ser Pro Thr Arg 
            20                  25                  30          


Phe Leu Asn Thr Met Val Val Ile His Asp Ser Gly Val Asp Pro Glu 
        35                  40                  45              


Gln Lys Lys Tyr Ala Ile Thr Arg Leu Ala Ser Ala Gly Thr Ala Arg 
    50                  55                  60                  


Arg Thr Arg Arg Leu Tyr Arg Thr Arg Arg Gln Arg Leu Arg Glu Leu 
65                  70                  75                  80  


Asp Asp Phe Ile Ser Asn Glu Leu Gly Tyr Pro Leu Val Asn Leu Glu 
                85                  90                  95      


Asn Phe Ala Asp Pro Tyr Glu Pro Trp Lys Val Arg Ala Asp Leu Ala 
            100                 105                 110         


Thr Thr Lys Leu Pro Asn Asp Glu Leu Pro Glu Ala Met Ser Ile Ala 
        115                 120                 125             


Leu Arg His Met Ala Arg His Arg Gly Trp Arg Ser Pro Tyr Gln Arg 
    130                 135                 140                 


Val Glu Ala Leu His Leu His Ala Glu Ile Ser Lys Glu Phe Ala Ala 
145                 150                 155                 160 


Leu Lys Glu Arg Val Val Glu Lys Thr Gly Asp Val Phe Ser Asp Asp 
                165                 170                 175     


Ala Thr Pro Ala Glu Val Leu Val Asp Leu Met Gly Arg Gln Lys Val 
            180                 185                 190         


Arg Gly Ala Asp Gly Val Leu Ser Gly Lys Leu Arg Gln Ser Asp Asn 
        195                 200                 205             


Ala Asn Glu Leu Arg Lys Ile Ala Ser Val Gln Gly Ile Asp Asp Glu 
    210                 215                 220                 


Thr Leu Asn Arg Ile Ile Asp Arg Val Phe Ser Ser Lys Ser Pro Lys 
225                 230                 235                 240 


Gly Lys Ala Ser Glu Arg Val Gly Met Asp Ala Leu Pro Gly Gln Gly 
                245                 250                 255     


Ser Lys Pro Arg Ala Leu Lys Ala Met Pro Ser Phe Gln Lys Phe Arg 
            260                 265                 270         


Val Val Ser Val Ile Cys Asn Leu Arg Ile Lys Asp Ser Gly Gly Asp 
        275                 280                 285             


Ala Arg Pro Leu Ser Met Glu Glu Lys Glu Lys Leu Ile Asp Tyr Leu 
    290                 295                 300                 


Met Ser Ser Thr Thr Asp Asp His Val Thr Trp Thr Asp Val Ala Asp 
305                 310                 315                 320 


Leu Leu His Val Lys Arg Ser Gln Leu Gln Gly Thr Ala Lys Glu Gly 
                325                 330                 335     


Phe Asp Gly Glu Arg Pro Tyr Thr Arg Pro Pro Val Asn Ser Thr Trp 
            340                 345                 350         


Ser Lys Ile Lys Asp Ser Lys Ile Lys Ser Leu Val Ala Leu Trp Lys 
        355                 360                 365             


Thr Gly Asp Val Asp Val Gln Ser Ala Ile Val Glu Ala Leu Ser Asn 
    370                 375                 380                 


Ala Ser Val Leu Glu Asp Ser Arg Pro Gly Ala Asp Ile Val Val Ala 
385                 390                 395                 400 


Tyr Leu Glu Ser Leu Asp Asp Lys Glu Leu Glu Ser Leu Asp Lys Val 
                405                 410                 415     


Gly Leu Pro Ala Gly Arg Ala Ser Tyr Ser Glu Asp Ser Leu Glu Arg 
            420                 425                 430         


Leu Thr Glu Arg Met Leu Arg Asp Asp Cys Asp Leu Phe Glu Ala Arg 
        435                 440                 445             


Lys Arg Glu Phe Asn Val Ala Asp Asp Trp Lys Pro Pro Ala Asp Pro 
    450                 455                 460                 


Ile Tyr Ala Pro Val Gly Asn Pro Gly Val Asp Arg Val Leu Lys Ile 
465                 470                 475                 480 


Val Asn Arg Leu Leu Met Ala Ala Glu Arg Glu Trp Gly Ala Pro Thr 
                485                 490                 495     


Gln Ile Asn Ile Glu His Val Arg Ser Gly Phe Ser Ser Glu Leu Met 
            500                 505                 510         


Gln Arg Glu Phe Glu Arg Glu Asn Glu Arg Arg Arg Ala Gln Asn Glu 
        515                 520                 525             


Glu Ala Val Lys Ala Ile Leu Thr Glu Lys Gly Gly Asn Ser Arg Val 
    530                 535                 540                 


Ser Lys Tyr Asp Ile Thr Arg Tyr Tyr Ala Val Lys Arg Gln His Cys 
545                 550                 555                 560 


Gln Cys Leu Tyr Cys Gly Thr Pro Ile Thr Phe Ser Asp Cys Glu Leu 
                565                 570                 575     


Asp His Ile Val Pro Arg Lys Gly Val Gly Ser Thr Asn Thr Arg Val 
            580                 585                 590         


Asn Leu Ala Ala Ala Cys Arg Ser Cys Asn Arg Asp Lys Ser Asn Leu 
        595                 600                 605             


Pro Phe Ala Val Trp Ala Gly Lys Ala Ser Asn Phe Asp Val Ser Ile 
    610                 615                 620                 


Asp Asp Ala Val Ser Arg Val Lys Gln Trp Gln Arg Ser Gln Asn Glu 
625                 630                 635                 640 


Gly Val Arg Glu Phe Arg Ala Phe Gln Asn Glu Val Ile Ser Arg Leu 
                645                 650                 655     


Leu Lys Thr Thr Glu Asp Pro Glu Ile Asp Ser Arg Ser Leu Glu Ser 
            660                 665                 670         


Val Ala Trp Met Ala Arg Glu Leu His His Arg Val Glu Tyr Tyr Phe 
        675                 680                 685             


Gln Ser Lys Gly Ala Gln Thr Gln Val Ser Val Tyr Arg Gly Ala Val 
    690                 695                 700                 


Thr Ala Gln Ala Arg Lys Ser Ser Gly Leu Glu Asp Lys Val Lys Met 
705                 710                 715                 720 


Ile Gly Gly Gly Gly Lys Thr Arg Leu Asp Arg Arg His His Ala Met 
                725                 730                 735     


Asp Ala Ala Thr Ile Ala Leu Met Thr Pro Gly Ile Ser Thr Thr Leu 
            740                 745                 750         


Ser Glu Lys Asn Asn Leu Arg Asp Ala Gln Lys Phe Thr Gly Gln Ser 
        755                 760                 765             


Glu Thr Trp Lys Asp Tyr Cys Gly Arg Thr Glu Thr Ala Arg Lys His 
    770                 775                 780                 


Phe Ala Val Trp Lys Ser Asn Met Glu Arg Leu Thr Asp Leu Phe Asn 
785                 790                 795                 800 


Asp Lys Leu Glu Asn Asp Ala Ile Pro Val Val Gln Pro Leu Arg Leu 
                805                 810                 815     


Arg Leu Ser Asn Ser Lys Ala His Asp Asp Gly Ile Gly Lys Leu Asp 
            820                 825                 830         


Ser Lys Lys Leu Gly Ser Val Trp Ser Leu Ala Asp Ile Asp Arg Ala 
        835                 840                 845             


Ala Thr Pro Gln Ile Trp Thr Ala Leu Thr Arg Cys Asp Asp Phe Asp 
    850                 855                 860                 


Pro Thr Lys Gly Leu Pro Glu Asn Ala Asn Arg Val Ile Arg Ala Gln 
865                 870                 875                 880 


Gly Val Lys Tyr Glu Ser Glu Asp Asn Ile Pro Val Phe Pro Ser Asn 
                885                 890                 895     


Val Ala Ala Ile Ala Val Arg Asp Gly Tyr Ala Glu Ile Gly Ser Thr 
            900                 905                 910         


Ile His His Ala Arg Ile Tyr Arg Ile Asp Asp Gly Lys Lys Thr Phe 
        915                 920                 925             


Tyr Ser Met Ile Arg Val Phe Ala Val Asp Leu Leu Lys His Gln Ala 
    930                 935                 940                 


Glu Asp Leu Phe Thr Val Lys Leu Pro Pro Ser Ala Ile Ser Ile Arg 
945                 950                 955                 960 


Thr Cys Glu Asp Ser Leu Arg Arg Ala Leu Ser Asn Gly Thr Ala Glu 
                965                 970                 975     


Tyr Leu Gly Trp Leu Val Pro Gly Asp Glu Ile Ile Val Asp Thr Ser 
            980                 985                 990         


Asp Lys Ala Phe His Thr Gly Gln  Ile Gly Asp Leu Leu  Arg Asn Phe 
        995                 1000                 1005             


Pro Val  Asn Ser Phe Arg Leu  Thr Gly Phe Pro Ser  Asn Ser Arg 
    1010                 1015                 1020             


Leu Arg  Leu Lys Pro Val Leu  Leu Ala Gly Glu Gly  Leu Arg Asp 
    1025                 1030                 1035             


Asp Ala  Glu Asp Ser Ile Lys  Lys Ile Leu Leu Gly  Gln Gly Trp 
    1040                 1045                 1050             


Arg Pro  Ala Ile Asn Val Leu  Phe Ser Lys Gly Lys  Pro Arg Ile 
    1055                 1060                 1065             


Val Arg  Arg Asn Ser Leu Gly  Ile Glu Arg Pro Ser  Ser Asn Asn 
    1070                 1075                 1080             


Gly Leu  Pro Phe Ser Trp Glu  Ala 
    1085                 1090     


<210> 321
<211> 1091
<212> PRT
<213> Mobiluncus mulieris


<220>
<223> Mobiluncus mulieris FB024-16

<400> 321
Met Asp Ser Arg Lys Tyr Arg Val Gly Ile Asp Val Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Phe Ala Ala Val Glu Glu Asp Asp Ser Gly Ser Pro Thr Arg 
            20                  25                  30          


Phe Leu Asn Thr Met Val Val Ile His Asp Ser Gly Val Asp Ser Glu 
        35                  40                  45              


Gln Lys Lys Tyr Ala Ile Thr Arg Leu Ala Ser Ala Gly Thr Ala Arg 
    50                  55                  60                  


Arg Thr Arg Arg Leu Tyr Arg Thr Arg Arg Gln Arg Leu Arg Glu Leu 
65                  70                  75                  80  


Asp Asp Phe Ile Ser Asn Glu Leu Gly Tyr Pro Leu Val Asn Leu Glu 
                85                  90                  95      


Asn Phe Ala Asp Pro Tyr Glu Pro Trp Lys Val Arg Ala Asp Leu Ala 
            100                 105                 110         


Thr Thr Lys Leu Pro Asn Asp Glu Leu Pro Glu Ala Met Ser Ile Ala 
        115                 120                 125             


Leu Arg His Met Ala Arg His Arg Gly Trp Arg Ser Pro Tyr Gln Arg 
    130                 135                 140                 


Val Glu Ala Leu His Leu His Ala Glu Ile Ser Lys Glu Phe Ala Ala 
145                 150                 155                 160 


Leu Lys Glu Arg Val Val Glu Lys Thr Gly Asp Val Phe Ser Asp Asp 
                165                 170                 175     


Ala Thr Pro Ala Glu Val Leu Val Asp Leu Met Gly Arg Gln Lys Val 
            180                 185                 190         


Arg Gly Ala Asp Gly Val Leu Ser Gly Lys Leu Arg Gln Ser Asp Asn 
        195                 200                 205             


Ala Asn Glu Leu Arg Lys Ile Ala Ser Val Gln Gly Ile Asp Asp Glu 
    210                 215                 220                 


Thr Leu Asn Arg Ile Ile Asp Arg Val Phe Ser Ser Lys Ser Pro Lys 
225                 230                 235                 240 


Gly Lys Ala Ser Glu Arg Val Gly Met Asp Ala Leu Pro Gly Gln Gly 
                245                 250                 255     


Ser Lys Pro Arg Ala Leu Lys Ala Met Pro Ser Phe Gln Lys Phe Arg 
            260                 265                 270         


Val Val Ser Val Ile Cys Asn Leu Arg Ile Lys Asp Ser Gly Gly Asp 
        275                 280                 285             


Ala Arg Pro Leu Ser Met Glu Glu Lys Glu Lys Leu Ile Asp Tyr Leu 
    290                 295                 300                 


Met Ser Ser Thr Thr Asp Asp His Val Thr Trp Thr Asp Val Ala Asp 
305                 310                 315                 320 


Leu Leu His Val Lys Arg Ser Gln Leu Gln Gly Thr Ala Lys Glu Gly 
                325                 330                 335     


Phe Asp Gly Glu Arg Pro Tyr Thr Arg Pro Pro Val Asn Ser Thr Trp 
            340                 345                 350         


Ser Lys Ile Lys Asp Ser Lys Ile Lys Ser Leu Val Ala Leu Trp Lys 
        355                 360                 365             


Thr Gly Asp Val Asp Val Gln Ser Ala Ile Val Glu Ala Leu Ser Asn 
    370                 375                 380                 


Ala Ser Val Leu Glu Asp Ser Arg Pro Gly Ala Asp Ile Val Val Ala 
385                 390                 395                 400 


Tyr Leu Glu Ser Leu Asp Asp Lys Glu Leu Glu Ser Leu Asp Lys Val 
                405                 410                 415     


Gly Leu Pro Ala Gly Arg Ala Ser Tyr Ser Glu Asp Ser Leu Glu Arg 
            420                 425                 430         


Leu Thr Glu Arg Met Leu Arg Asp Asp Cys Asp Leu Phe Glu Ala Arg 
        435                 440                 445             


Lys Arg Glu Phe Asn Val Ala Asp Asp Trp Lys Pro Pro Ala Asp Pro 
    450                 455                 460                 


Ile Tyr Ala Pro Val Gly Asn Pro Gly Val Asp Arg Val Leu Lys Ile 
465                 470                 475                 480 


Val Asn Arg Leu Leu Met Ala Ala Glu Arg Glu Trp Gly Ala Pro Thr 
                485                 490                 495     


Gln Ile Asn Ile Glu His Val Arg Ser Gly Phe Ser Ser Glu Leu Met 
            500                 505                 510         


Gln Arg Glu Phe Glu Arg Glu Asn Glu Arg Arg Arg Ala Gln Asn Glu 
        515                 520                 525             


Glu Ala Val Lys Ala Ile Leu Thr Glu Lys Gly Gly Asn Ser Arg Val 
    530                 535                 540                 


Ser Lys Tyr Asp Ile Thr Arg Tyr Tyr Ala Val Lys Arg Gln His Cys 
545                 550                 555                 560 


Gln Cys Leu Tyr Cys Gly Thr Pro Ile Thr Phe Ser Asp Cys Glu Leu 
                565                 570                 575     


Asp His Ile Val Pro Arg Lys Gly Val Gly Ser Thr Asn Thr Arg Val 
            580                 585                 590         


Asn Leu Ala Ala Ala Cys Arg Ser Cys Asn Arg Asp Lys Ser Asn Leu 
        595                 600                 605             


Pro Phe Ala Val Trp Ala Gly Lys Ala Ser Asn Phe Asp Val Ser Ile 
    610                 615                 620                 


Asp Asp Ala Val Ser Arg Val Lys Gln Trp Gln Arg Ser Gln Asn Glu 
625                 630                 635                 640 


Gly Val Arg Glu Phe Arg Ala Phe Gln Asn Glu Val Ile Ser Arg Leu 
                645                 650                 655     


Leu Lys Thr Thr Glu Asp Pro Glu Ile Asp Ser Arg Ser Leu Glu Ser 
            660                 665                 670         


Val Ala Trp Met Ala Arg Glu Leu His His Arg Val Glu Tyr Tyr Phe 
        675                 680                 685             


Gln Ser Lys Gly Ala Gln Thr Gln Val Ser Val Tyr Arg Gly Ala Val 
    690                 695                 700                 


Thr Ala Gln Ala Arg Lys Ser Ser Gly Leu Glu Asp Lys Val Lys Met 
705                 710                 715                 720 


Ile Gly Gly Gly Gly Lys Thr Arg Leu Asp Arg Arg His His Ala Met 
                725                 730                 735     


Asp Ala Ala Thr Ile Ala Leu Met Thr Pro Gly Ile Ser Thr Thr Leu 
            740                 745                 750         


Ser Glu Lys Asn Asn Leu Arg Asp Ala Gln Lys Phe Thr Gly Gln Ser 
        755                 760                 765             


Glu Thr Trp Lys Asp Tyr Cys Gly Arg Thr Glu Thr Ala Arg Lys His 
    770                 775                 780                 


Phe Ala Val Trp Lys Ser Asn Met Glu Arg Leu Thr Asp Leu Phe Asn 
785                 790                 795                 800 


Asp Lys Leu Glu Asn Asp Ala Ile Pro Val Val Gln Pro Leu Arg Leu 
                805                 810                 815     


Arg Leu Ser Asn Ser Lys Ala His Asp Asp Gly Ile Gly Lys Leu Asp 
            820                 825                 830         


Ser Lys Lys Leu Gly Ser Val Trp Ser Leu Ala Asp Ile Asp Arg Ala 
        835                 840                 845             


Ala Thr Pro Gln Ile Trp Thr Ala Leu Thr Arg Cys Asp Asp Phe Asp 
    850                 855                 860                 


Pro Thr Lys Gly Leu Pro Glu Asn Ala Asn Arg Val Ile Arg Ala Gln 
865                 870                 875                 880 


Gly Val Lys Tyr Glu Ser Glu Asp Asn Ile Pro Val Phe Pro Ser Asn 
                885                 890                 895     


Val Ala Ala Ile Ala Val Arg Asp Gly Tyr Ala Glu Ile Gly Ser Thr 
            900                 905                 910         


Ile His His Ala Arg Ile Tyr Arg Ile Asp Asp Gly Lys Lys Thr Phe 
        915                 920                 925             


Tyr Ser Met Ile Arg Val Phe Ala Val Asp Leu Leu Lys His Gln Ala 
    930                 935                 940                 


Glu Asp Leu Phe Thr Val Lys Leu Pro Pro Ser Ala Ile Ser Ile Arg 
945                 950                 955                 960 


Thr Cys Glu Asp Ser Leu Arg Arg Ala Leu Ser Asn Gly Thr Ala Glu 
                965                 970                 975     


Tyr Leu Gly Trp Leu Val Pro Gly Asp Glu Ile Ile Val Asp Thr Ser 
            980                 985                 990         


Asp Lys Ala Phe His Thr Gly Gln  Ile Gly Asp Leu Leu  Arg Asn Phe 
        995                 1000                 1005             


Pro Val  Asn Ser Phe Arg Leu  Thr Gly Phe Pro Ser  Asn Ser Arg 
    1010                 1015                 1020             


Leu Arg  Leu Lys Pro Val Leu  Leu Ala Gly Glu Gly  Leu Arg Asp 
    1025                 1030                 1035             


Asp Ala  Glu Asp Ser Ile Lys  Lys Ile Leu Leu Gly  Gln Gly Trp 
    1040                 1045                 1050             


Arg Pro  Ala Ile Asn Val Leu  Phe Ser Lys Gly Lys  Pro Arg Ile 
    1055                 1060                 1065             


Val Arg  Arg Asn Ser Leu Gly  Ile Glu Arg Pro Ser  Ser Asn Asn 
    1070                 1075                 1080             


Gly Leu  Pro Phe Ser Trp Glu  Ala 
    1085                 1090     


<210> 322
<211> 1473
<212> PRT
<213> Mucilaginibacter paludis


<220>
<223> Mucilaginibacter paludis DSM 18603

<400> 322
Met Lys Asn Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Ile Glu Lys Asp Thr Asp Gln Lys Asn Gly Asn Ile Leu Gly 
            20                  25                  30          


Thr Gly Ser Arg Ile Ile Pro Met Ser Gln Asp Ile Lys Asp Glu Phe 
        35                  40                  45              


Gly Lys Gly Asn Ser Ile Ser Gln Thr Ala Asp Arg Thr Lys Phe Arg 
    50                  55                  60                  


Ser Val Arg Arg Leu Arg Glu Arg His Leu Leu Arg Arg Glu Arg Leu 
65                  70                  75                  80  


His Arg Val Leu Asn Val Leu Gly Phe Leu Pro Lys His Tyr Ala Asp 
                85                  90                  95      


Gln Ile Asp Phe Lys Lys Arg Leu Gly Lys Leu Val Asn Glu Thr Glu 
            100                 105                 110         


Pro Lys Leu Val Tyr Asp Asn Lys Asn Phe Ile Phe Lys Lys Ser Phe 
        115                 120                 125             


Glu Ala Met Leu Ser Asp Phe Asn Gln His Gln Pro Leu Leu Leu Ala 
    130                 135                 140                 


Asp Gly Lys Lys Val Pro Phe Asp Trp Thr Ile Tyr Tyr Leu Arg Lys 
145                 150                 155                 160 


Lys Ala Leu Thr Glu Lys Ile Glu Lys Glu Glu Leu Ala Trp Leu Ile 
                165                 170                 175     


Leu Asn Phe Asn Gln Lys Arg Gly Tyr Tyr Gln Leu Arg Gly Glu Glu 
            180                 185                 190         


Glu Glu Glu Asn Pro Asn Lys Met Val Ala Phe His Ser Leu Lys Ile 
        195                 200                 205             


Val Glu Val Ile Ala Asp Glu Ser Gln Lys Gly Lys Ala Glu Thr Trp 
    210                 215                 220                 


Tyr Ser Leu Ile Leu Glu Asn Gly Trp Ile Tyr Arg Arg Ser Ser Lys 
225                 230                 235                 240 


Thr Pro Leu Tyr Asp Trp Lys Gly Lys Gln Arg Asp Phe Ile Val Thr 
                245                 250                 255     


Thr Asp Leu Asn Asp Asp Gly Ser Ile Lys Thr Asp Lys Glu Gly Leu 
            260                 265                 270         


Glu Lys Arg Ser Phe Arg Ala Pro Val Glu Asp Asp Trp Thr Leu Val 
        275                 280                 285             


Lys Lys Lys Thr Glu Gln Glu Ile Asn Arg Ser His Lys Thr Val Gly 
    290                 295                 300                 


Thr Tyr Ile Tyr Glu Asn Leu Leu Gln Asp Pro Lys Gln Lys Ile Lys 
305                 310                 315                 320 


Gly Lys Leu Val Arg Thr Ile Glu Arg Glu Phe Tyr Lys Asp Glu Leu 
                325                 330                 335     


Lys Met Ile Leu Lys Asn Gln Gln Lys Phe His Pro Glu Leu Asn Asp 
            340                 345                 350         


Glu His Leu Tyr Ile Asn Cys Val Arg Glu Leu Tyr Arg Asn Asn Gln 
        355                 360                 365             


Ala His Gln Thr Ile Leu Ser Lys Lys Asp Phe Val His Leu Phe Ile 
    370                 375                 380                 


Asp Asp Ile Ile Phe Tyr Gln Arg Pro Leu Arg Ser Gln Lys Ser Ser 
385                 390                 395                 400 


Ile Ser Asn Cys Thr Leu Glu Phe Arg Lys Tyr Lys Asn Glu Asn Gly 
                405                 410                 415     


Thr Asp Gln Thr Asp Tyr Leu Lys Ala Ile Pro Lys Ser His Pro Leu 
            420                 425                 430         


Phe Gln Glu Phe Arg Leu Trp Gln Trp Ile Tyr Asn Leu Gly Ile Tyr 
        435                 440                 445             


Gln Lys Glu Asp Asp Thr Asn Val Thr Asp Glu Leu Ile Lys Asn Ile 
    450                 455                 460                 


Asp Gly Tyr Gln Asp Leu Phe Asp Phe Leu Asn Asn Lys Lys Glu Ile 
465                 470                 475                 480 


Arg Gln Asp Ile Leu Ile Lys Phe Leu Val Glu Gln Thr Gly Leu Lys 
                485                 490                 495     


Gly Lys Pro Leu Ser Ser Val Val Ala Lys Tyr Arg Trp Asn Phe Val 
            500                 505                 510         


Glu Asp Lys Ile Tyr Pro Cys Asn Glu Thr Gly Thr Gln Ile Arg Thr 
        515                 520                 525             


Arg Leu Ala Lys Val Glu Asn Thr Pro Glu Asp Phe Leu Thr Ala Glu 
    530                 535                 540                 


Thr Glu Ile Lys Leu Trp His Ile Ile Tyr Ser Val Asn Asp Lys Ala 
545                 550                 555                 560 


Asp Tyr Glu Lys Ala Leu Lys Thr Phe Ala Glu Lys His Asn Leu Asp 
                565                 570                 575     


Thr His Ser Phe Val Glu Asn Phe Lys Lys Phe Pro Pro Phe Lys Ser 
            580                 585                 590         


Glu Tyr Gly Ser Phe Ser Glu Lys Ala Ile Lys Lys Leu Leu Pro Leu 
        595                 600                 605             


Ile Arg Leu Gly Lys Tyr Trp Ser Trp Glu Asn Ile Asp Lys Lys Thr 
    610                 615                 620                 


Gln Glu Arg Ile Glu Lys Ile Leu Thr Gly Glu Phe Asp Glu Ala Ile 
625                 630                 635                 640 


Lys Ser Arg Val Arg Asp Lys Ala Ile His Leu Thr Glu Glu Asp His 
                645                 650                 655     


Phe Gln Gly Leu Gln Leu Trp Leu Ala Ser Tyr Val Val Tyr Gly Arg 
            660                 665                 670         


His Ser Glu Ala Asp Asn Leu Asp Lys Trp His Thr Val Ala Asp Leu 
        675                 680                 685             


Glu Asp Tyr Leu Ala Glu Phe Arg Gln His Ser Leu Arg Asn Pro Ile 
    690                 695                 700                 


Val Glu Gln Val Ile Thr Glu Thr Leu Arg Val Val Lys Asp Ile Trp 
705                 710                 715                 720 


Leu Gln Tyr Gly Gln Gly Ala Lys Asp Phe Phe Ser Glu Ile His Ile 
                725                 730                 735     


Glu Leu Ala Arg Glu Met Lys Asn Thr Gly Asp Glu Arg Lys Arg Leu 
            740                 745                 750         


Thr Ser Leu Val Thr Asp Asn Glu Asn Thr Asn Leu Arg Ile Lys Val 
        755                 760                 765             


Leu Leu Ser Glu Leu Leu Asn Asp Gly Asn Val Glu Asn Val Arg Pro 
    770                 775                 780                 


Tyr Ser Pro Met Gln Gln Glu Ala Leu Lys Ile Phe Glu Asp Gly Val 
785                 790                 795                 800 


Leu Asn Ser Asp Ile Glu Ile Glu Asp Asp Ile Leu Lys Ile Ser Lys 
                805                 810                 815     


Met Ala Gln Pro Thr Asn Thr Glu Leu Lys Arg Tyr Lys Leu Trp Leu 
            820                 825                 830         


Glu Gln Lys Tyr Arg Ser Pro Tyr Thr Gly Gln Ile Ile Pro Leu Asn 
        835                 840                 845             


Arg Leu Phe Thr Ala Asp Tyr Glu Ile Glu His Ile Ile Pro Gln Ser 
    850                 855                 860                 


Arg Phe Phe Asp Asp Ser Phe Ser Asn Lys Ile Ile Cys Glu Ser Ala 
865                 870                 875                 880 


Val Asn Gln Leu Lys Asp Lys Gln Leu Gly Leu Glu Phe Ile Lys Asn 
                885                 890                 895     


His Ser Gly Thr Ile Val Lys Leu Gly Met Gly Lys Thr Ala Lys Ile 
            900                 905                 910         


Leu Asp Val Glu Ser Tyr Asn Glu Phe Val Lys Gly Asn Tyr Thr Lys 
        915                 920                 925             


Asn Ile Ser Lys Arg Asn Lys Leu Met Leu Glu Glu Ile Pro Asp Lys 
    930                 935                 940                 


Met Ile Glu Arg Gln Leu Asn Asp Thr Arg Tyr Ile Ser Lys Phe Ile 
945                 950                 955                 960 


Ile Ser Ala Leu Ser Asn Ile Val Arg Ser Glu Ser Asn Asp Asp Gly 
                965                 970                 975     


Phe Asn Ser Lys Asn Val Leu Pro Gly Asn Gly Lys Ile Thr Ser Arg 
            980                 985                 990         


Leu Lys Gln Asp Trp Gly Met Asn  Asp Ile Trp Asn Glu  Leu Ile Leu 
        995                 1000                 1005             


Pro Arg  Phe Glu Arg Met Asn  Lys Ile Thr Asp Ser  Ala Val Phe 
    1010                 1015                 1020             


Thr Ala  Trp Asn Glu Asn Asn  Gln Lys Phe Leu Pro  Ile Val Pro 
    1025                 1030                 1035             


Leu Glu  Phe Ser Lys Gly Phe  Gln Lys Lys Arg Ile  Asp His Arg 
    1040                 1045                 1050             


His His  Ala Leu Asp Ala Leu  Val Ile Ala Ala Ser  Thr Arg Glu 
    1055                 1060                 1065             


His Ile  Asn Leu Leu Asn Asn  Glu His Ala Lys Ser  Asp Lys Arg 
    1070                 1075                 1080             


Phe Asp  Leu Asn Arg Lys Leu  Arg Lys Phe Glu Lys  Val Ala Tyr 
    1085                 1090                 1095             


Asn Asp  Pro Lys Thr Gly Lys  Arg Ile Glu Lys Glu  Val Pro Thr 
    1100                 1105                 1110             


Ile Phe  Leu Lys Pro Trp Glu  Thr Phe Thr Val Asp  Ala Lys Asn 
    1115                 1120                 1125             


Ser Leu  Glu Ser Ile Ile Val  Ser Phe Lys Gln Asn  Leu Arg Val 
    1130                 1135                 1140             


Ile Asn  Arg Ala Thr Asn Tyr  Ser Glu Ser Tyr Asn  Asp Glu Asn 
    1145                 1150                 1155             


Gly Ala  Leu Arg Leu Gly Lys  Asp Gly Asn Pro Leu  Lys Glu Lys 
    1160                 1165                 1170             


Ile Lys  Gln Ser Lys Gly Asp  Ser Trp Ala Ile Arg  Lys Pro Met 
    1175                 1180                 1185             


His Lys  Asp Phe Val Tyr Gly  Lys Val His Leu Gln  Asn Val Lys 
    1190                 1195                 1200             


Leu Pro  Lys Asp Lys Phe Ile  Thr Ala Ile Arg Lys  Ser Leu Asp 
    1205                 1210                 1215             


Val Thr  Phe Asp Leu Lys Arg  Ile Glu Thr Ile Thr  Asp Thr Gly 
    1220                 1225                 1230             


Ile Gln  Lys Ile Leu Lys Asn  Tyr Leu His Ser Lys  Glu Asn Lys 
    1235                 1240                 1245             


Val Glu  Leu Ala Phe Ser Pro  Glu Gly Ile Glu Asp  Met Asn Gln 
    1250                 1255                 1260             


His Ile  Glu Arg Tyr Asn Asp  Gly Lys Lys His Gln  Pro Ile His 
    1265                 1270                 1275             


Lys Val  Arg Val Phe Glu Ile  Gly Ser Arg Phe Ser  Leu Gly Glu 
    1280                 1285                 1290             


Ser Gly  Asn Lys Lys Thr Lys  Phe Val Glu Ala Ala  Lys Gly Thr 
    1295                 1300                 1305             


Asn Leu  Phe Phe Ala Val Tyr  Gln Asp Asp Asn Lys  Gly Lys Arg 
    1310                 1315                 1320             


Asn Tyr  Glu Thr Ile Pro Leu  Asn Ile Val Ile Glu  Arg Gln Lys 
    1325                 1330                 1335             


Leu Gly  Leu His Ser Val Pro  Thr Glu Asp Ala Lys  Gly Gly Lys 
    1340                 1345                 1350             


Leu Leu  Phe His Leu Ser Pro  Asn Asp Met Val Tyr  Val Pro Thr 
    1355                 1360                 1365             


Ser Glu  Glu Leu Glu Asp Asn  Leu Ala Ser Val Asn  Ile Lys Arg 
    1370                 1375                 1380             


Leu Asn  Thr Ala Gln Arg Lys  Arg Ile Tyr Lys Val  Glu Lys Ala 
    1385                 1390                 1395             


Ser Gly  Val Glu Cys Tyr Phe  Ile Arg Gln Asp Ile  Ala Tyr Leu 
    1400                 1405                 1410             


Ile Lys  Asn Tyr Asp Ala Lys  Thr Lys Ile Gly Glu  Leu Glu Ser 
    1415                 1420                 1425             


Gln Asn  Lys Leu Gln Thr Thr  Met Thr Asp Asp Arg  Leu Lys Ile 
    1430                 1435                 1440             


Thr Asp  Val Cys Val Lys Leu  Asn Ile Asp Arg Leu  Gly Ser Ile 
    1445                 1450                 1455             


Ala Glu  Thr Phe Leu Gly Asn  Gln Tyr Gly Ala Ser  Lys Lys Thr 
    1460                 1465                 1470             


<210> 323
<211> 1233
<212> PRT
<213> Mycoplasma canis


<220>
<223> Mycoplasma canis PG 14

<400> 323
Met Glu Lys Lys Arg Lys Val Thr Leu Gly Phe Asp Leu Gly Ile Ala 
1               5                   10                  15      


Ser Val Gly Trp Ala Ile Val Asp Ser Glu Thr Asn Gln Val Tyr Lys 
            20                  25                  30          


Leu Gly Ser Arg Leu Phe Asp Ala Pro Asp Thr Asn Leu Glu Arg Arg 
        35                  40                  45              


Thr Gln Arg Gly Thr Arg Arg Leu Leu Arg Arg Arg Lys Tyr Arg Asn 
    50                  55                  60                  


Gln Lys Phe Tyr Asn Leu Val Lys Arg Thr Glu Val Phe Gly Leu Ser 
65                  70                  75                  80  


Ser Arg Glu Ala Ile Glu Asn Arg Phe Arg Glu Leu Ser Ile Lys Tyr 
                85                  90                  95      


Pro Asn Ile Ile Glu Leu Lys Thr Lys Ala Leu Ser Gln Glu Val Cys 
            100                 105                 110         


Pro Asp Glu Ile Ala Trp Ile Leu His Asp Tyr Leu Lys Asn Arg Gly 
        115                 120                 125             


Tyr Phe Tyr Asp Glu Lys Glu Thr Lys Glu Asp Phe Asp Gln Gln Thr 
    130                 135                 140                 


Val Glu Ser Met Pro Ser Tyr Lys Leu Asn Glu Phe Tyr Lys Lys Tyr 
145                 150                 155                 160 


Gly Tyr Phe Lys Gly Ala Leu Ser Gln Pro Thr Glu Ser Glu Met Lys 
                165                 170                 175     


Asp Asn Lys Asp Leu Lys Glu Ala Phe Phe Phe Asp Phe Ser Asn Lys 
            180                 185                 190         


Glu Trp Leu Lys Glu Ile Asn Tyr Phe Phe Asn Val Gln Lys Asn Ile 
        195                 200                 205             


Leu Ser Glu Thr Phe Ile Glu Glu Phe Lys Lys Ile Phe Ser Phe Thr 
    210                 215                 220                 


Arg Asp Ile Ser Lys Gly Pro Gly Ser Asp Asn Met Pro Ser Pro Tyr 
225                 230                 235                 240 


Gly Ile Phe Gly Glu Phe Gly Asp Asn Gly Gln Gly Gly Arg Tyr Glu 
                245                 250                 255     


His Ile Trp Asp Lys Asn Ile Gly Lys Cys Ser Ile Phe Thr Asn Glu 
            260                 265                 270         


Gln Arg Ala Pro Lys Tyr Leu Pro Ser Ala Leu Ile Phe Asn Phe Leu 
        275                 280                 285             


Asn Glu Leu Ala Asn Ile Arg Leu Tyr Ser Thr Asp Lys Lys Asn Ile 
    290                 295                 300                 


Gln Pro Leu Trp Lys Leu Ser Ser Val Asp Lys Leu Asn Ile Leu Leu 
305                 310                 315                 320 


Asn Leu Phe Asn Leu Pro Ile Ser Glu Lys Lys Lys Lys Leu Thr Ser 
                325                 330                 335     


Thr Asn Ile Asn Asp Ile Val Lys Lys Glu Ser Ile Lys Ser Ile Met 
            340                 345                 350         


Ile Ser Val Glu Asp Ile Asp Met Ile Lys Asp Glu Trp Ala Gly Lys 
        355                 360                 365             


Glu Pro Asn Val Tyr Gly Val Gly Leu Ser Gly Leu Asn Ile Glu Glu 
    370                 375                 380                 


Ser Ala Lys Glu Asn Lys Phe Lys Phe Gln Asp Leu Lys Ile Leu Asn 
385                 390                 395                 400 


Val Leu Ile Asn Leu Leu Asp Asn Val Gly Ile Lys Phe Glu Phe Lys 
                405                 410                 415     


Asp Arg Asn Asp Ile Ile Lys Asn Leu Glu Leu Leu Asp Asn Leu Tyr 
            420                 425                 430         


Leu Phe Leu Ile Tyr Gln Lys Glu Ser Asn Asn Lys Asp Ser Ser Ile 
        435                 440                 445             


Asp Leu Phe Ile Ala Lys Asn Glu Ser Leu Asn Ile Glu Asn Leu Lys 
    450                 455                 460                 


Leu Lys Leu Lys Glu Phe Leu Leu Gly Ala Gly Asn Glu Phe Glu Asn 
465                 470                 475                 480 


His Asn Ser Lys Thr His Ser Leu Ser Lys Lys Ala Ile Asp Glu Ile 
                485                 490                 495     


Leu Pro Lys Leu Leu Asp Asn Asn Glu Gly Trp Asn Leu Glu Ala Ile 
            500                 505                 510         


Lys Asn Tyr Asp Glu Glu Ile Lys Ser Gln Ile Glu Asp Asn Ser Ser 
        515                 520                 525             


Leu Met Ala Lys Gln Asp Lys Lys Tyr Leu Asn Asp Asn Phe Leu Lys 
    530                 535                 540                 


Asp Ala Ile Leu Pro Pro Asn Val Lys Val Thr Phe Gln Gln Ala Ile 
545                 550                 555                 560 


Leu Ile Phe Asn Lys Ile Ile Gln Lys Phe Ser Lys Asp Phe Glu Ile 
                565                 570                 575     


Asp Lys Val Val Ile Glu Leu Ala Arg Glu Met Thr Gln Asp Gln Glu 
            580                 585                 590         


Asn Asp Ala Leu Lys Gly Ile Ala Lys Ala Gln Lys Ser Lys Lys Ser 
        595                 600                 605             


Leu Val Glu Glu Arg Leu Glu Ala Asn Asn Ile Asp Lys Ser Val Phe 
    610                 615                 620                 


Asn Asp Lys Tyr Glu Lys Leu Ile Tyr Lys Ile Phe Leu Trp Ile Ser 
625                 630                 635                 640 


Gln Asp Phe Lys Asp Pro Tyr Thr Gly Ala Gln Ile Ser Val Asn Glu 
                645                 650                 655     


Ile Val Asn Asn Lys Val Glu Ile Asp His Ile Ile Pro Tyr Ser Leu 
            660                 665                 670         


Cys Phe Asp Asp Ser Ser Ala Asn Lys Val Leu Val His Lys Gln Ser 
        675                 680                 685             


Asn Gln Glu Lys Ser Asn Ser Leu Pro Tyr Glu Tyr Ile Lys Gln Gly 
    690                 695                 700                 


His Ser Gly Trp Asn Trp Asp Glu Phe Thr Lys Tyr Val Lys Arg Val 
705                 710                 715                 720 


Phe Val Asn Asn Val Asp Ser Ile Leu Ser Lys Lys Glu Arg Leu Lys 
                725                 730                 735     


Lys Ser Glu Asn Leu Leu Thr Ala Ser Tyr Asp Gly Tyr Asp Lys Leu 
            740                 745                 750         


Gly Phe Leu Ala Arg Asn Leu Asn Asp Thr Arg Tyr Ala Thr Ile Leu 
        755                 760                 765             


Phe Arg Asp Gln Leu Asn Asn Tyr Ala Glu His His Leu Ile Asp Asn 
    770                 775                 780                 


Lys Lys Met Phe Lys Val Ile Ala Met Asn Gly Ala Val Thr Ser Phe 
785                 790                 795                 800 


Ile Arg Lys Asn Met Ser Tyr Asp Asn Lys Leu Arg Leu Lys Asp Arg 
                805                 810                 815     


Ser Asp Phe Ser His His Ala Tyr Asp Ala Ala Ile Ile Ala Leu Phe 
            820                 825                 830         


Ser Asn Lys Thr Lys Thr Leu Tyr Asn Leu Ile Asp Pro Ser Leu Asn 
        835                 840                 845             


Gly Ile Ile Ser Lys Arg Ser Glu Gly Tyr Trp Val Ile Glu Asp Arg 
    850                 855                 860                 


Tyr Thr Gly Glu Ile Lys Glu Leu Lys Lys Glu Asp Trp Thr Ser Ile 
865                 870                 875                 880 


Lys Asn Asn Val Gln Ala Arg Lys Ile Ala Lys Glu Ile Glu Glu Tyr 
                885                 890                 895     


Leu Ile Asp Leu Asp Asp Glu Val Phe Phe Ser Arg Lys Thr Lys Arg 
            900                 905                 910         


Lys Thr Asn Arg Gln Leu Tyr Asn Glu Thr Ile Tyr Gly Ile Ala Thr 
        915                 920                 925             


Lys Thr Asp Glu Asp Gly Ile Thr Asn Tyr Tyr Lys Lys Glu Lys Phe 
    930                 935                 940                 


Ser Ile Leu Asp Asp Lys Asp Ile Tyr Leu Arg Leu Leu Arg Glu Arg 
945                 950                 955                 960 


Glu Lys Phe Val Ile Asn Gln Ser Asn Pro Glu Val Ile Asp Gln Ile 
                965                 970                 975     


Ile Glu Ile Ile Glu Ser Tyr Gly Lys Glu Asn Asn Ile Pro Ser Arg 
            980                 985                 990         


Asp Glu Ala Ile Asn Ile Lys Tyr  Thr Lys Asn Lys Ile  Asn Tyr Asn 
        995                 1000                 1005             


Leu Tyr  Leu Lys Gln Tyr Met  Arg Ser Leu Thr Lys  Ser Leu Asp 
    1010                 1015                 1020             


Gln Phe  Ser Glu Glu Phe Ile  Asn Gln Met Ile Ala  Asn Lys Thr 
    1025                 1030                 1035             


Phe Val  Leu Tyr Asn Pro Thr  Lys Asn Thr Thr Arg  Lys Ile Lys 
    1040                 1045                 1050             


Phe Leu  Arg Leu Val Asn Asp  Val Lys Ile Asn Asp  Ile Arg Lys 
    1055                 1060                 1065             


Asn Gln  Val Ile Asn Lys Phe  Asn Gly Lys Asn Asn  Glu Pro Lys 
    1070                 1075                 1080             


Ala Phe  Tyr Glu Asn Ile Asn  Ser Leu Gly Ala Ile  Val Phe Lys 
    1085                 1090                 1095             


Asn Ser  Ala Asn Asn Phe Lys  Thr Leu Ser Ile Asn  Thr Gln Ile 
    1100                 1105                 1110             


Ala Ile  Phe Gly Asp Lys Asn  Trp Asp Ile Glu Asp  Phe Lys Thr 
    1115                 1120                 1125             


Tyr Asn  Met Glu Lys Ile Glu  Lys Tyr Lys Glu Ile  Tyr Gly Ile 
    1130                 1135                 1140             


Asp Lys  Thr Tyr Asn Phe His  Ser Phe Ile Phe Pro  Gly Thr Ile 
    1145                 1150                 1155             


Leu Leu  Asp Lys Gln Asn Lys  Glu Phe Tyr Tyr Ile  Ser Ser Ile 
    1160                 1165                 1170             


Gln Thr  Val Arg Asp Ile Ile  Glu Ile Lys Phe Leu  Asn Lys Ile 
    1175                 1180                 1185             


Glu Phe  Lys Asp Glu Asn Lys  Asn Gln Asp Thr Ser  Lys Thr Pro 
    1190                 1195                 1200             


Lys Arg  Leu Met Phe Gly Ile  Lys Ser Ile Met Asn  Asn Tyr Glu 
    1205                 1210                 1215             


Gln Val  Asp Ile Ser Pro Phe  Gly Ile Asn Lys Lys  Ile Phe Glu 
    1220                 1225                 1230             


<210> 324
<211> 1233
<212> PRT
<213> Mycoplasma canis


<220>
<223> Mycoplasma canis PG 14

<400> 324
Met Glu Lys Lys Arg Lys Val Thr Leu Gly Phe Asp Leu Gly Ile Ala 
1               5                   10                  15      


Ser Val Gly Trp Ala Ile Val Asp Ser Glu Thr Asn Gln Val Tyr Lys 
            20                  25                  30          


Leu Gly Ser Arg Leu Phe Asp Ala Pro Asp Thr Asn Leu Glu Arg Arg 
        35                  40                  45              


Thr Gln Arg Gly Thr Arg Arg Leu Leu Arg Arg Arg Lys Tyr Arg Asn 
    50                  55                  60                  


Gln Lys Phe Tyr Asn Leu Val Lys Arg Thr Glu Val Phe Gly Leu Ser 
65                  70                  75                  80  


Ser Arg Glu Ala Ile Glu Asn Arg Phe Arg Glu Leu Ser Ile Lys Tyr 
                85                  90                  95      


Pro Asn Ile Ile Glu Leu Lys Thr Lys Ala Leu Ser Gln Glu Val Cys 
            100                 105                 110         


Pro Asp Glu Ile Ala Trp Ile Leu His Asp Tyr Leu Lys Asn Arg Gly 
        115                 120                 125             


Tyr Phe Tyr Asp Glu Lys Glu Thr Lys Glu Asp Phe Asp Gln Gln Thr 
    130                 135                 140                 


Val Glu Ser Met Pro Ser Tyr Lys Leu Asn Glu Phe Tyr Lys Lys Tyr 
145                 150                 155                 160 


Gly Tyr Phe Lys Gly Ala Leu Ser Gln Pro Thr Glu Ser Glu Met Lys 
                165                 170                 175     


Asp Asn Lys Asp Leu Lys Glu Ala Phe Phe Phe Asp Phe Ser Asn Lys 
            180                 185                 190         


Glu Trp Leu Lys Glu Ile Asn Tyr Phe Phe Asn Val Gln Lys Asn Ile 
        195                 200                 205             


Leu Ser Glu Thr Phe Ile Glu Glu Phe Lys Lys Ile Phe Ser Phe Thr 
    210                 215                 220                 


Arg Asp Ile Ser Lys Gly Pro Gly Ser Asp Asn Met Pro Ser Pro Tyr 
225                 230                 235                 240 


Gly Ile Phe Gly Glu Phe Gly Asp Asn Gly Gln Gly Gly Arg Tyr Glu 
                245                 250                 255     


His Ile Trp Asp Lys Asn Ile Gly Lys Cys Ser Ile Phe Thr Asn Glu 
            260                 265                 270         


Gln Arg Ala Pro Lys Tyr Leu Pro Ser Ala Leu Ile Phe Asn Phe Leu 
        275                 280                 285             


Asn Glu Leu Ala Asn Ile Arg Leu Tyr Ser Thr Asp Lys Lys Asn Ile 
    290                 295                 300                 


Gln Pro Leu Trp Lys Leu Ser Ser Val Asp Lys Leu Asn Ile Leu Leu 
305                 310                 315                 320 


Asn Leu Phe Asn Leu Pro Ile Ser Glu Lys Lys Lys Lys Leu Thr Ser 
                325                 330                 335     


Thr Asn Ile Asn Asp Ile Val Lys Lys Glu Ser Ile Lys Ser Ile Met 
            340                 345                 350         


Ile Ser Val Glu Asp Ile Asp Met Ile Lys Asp Glu Trp Ala Gly Lys 
        355                 360                 365             


Glu Pro Asn Val Tyr Gly Val Gly Leu Ser Gly Leu Asn Ile Glu Glu 
    370                 375                 380                 


Ser Ala Lys Glu Asn Lys Phe Lys Phe Gln Asp Leu Lys Ile Leu Asn 
385                 390                 395                 400 


Val Leu Ile Asn Leu Leu Asp Asn Val Gly Ile Lys Phe Glu Phe Lys 
                405                 410                 415     


Asp Arg Asn Asp Ile Ile Lys Asn Leu Glu Leu Leu Asp Asn Leu Tyr 
            420                 425                 430         


Leu Phe Leu Ile Tyr Gln Lys Glu Ser Asn Asn Lys Asp Ser Ser Ile 
        435                 440                 445             


Asp Leu Phe Ile Ala Lys Asn Glu Ser Leu Asn Ile Glu Asn Leu Lys 
    450                 455                 460                 


Leu Lys Leu Lys Glu Phe Leu Leu Gly Ala Gly Asn Glu Phe Glu Asn 
465                 470                 475                 480 


His Asn Ser Lys Thr His Ser Leu Ser Lys Lys Ala Ile Asp Glu Ile 
                485                 490                 495     


Leu Pro Lys Leu Leu Asp Asn Asn Glu Gly Trp Asn Leu Glu Ala Ile 
            500                 505                 510         


Lys Asn Tyr Asp Glu Glu Ile Lys Ser Gln Ile Glu Asp Asn Ser Ser 
        515                 520                 525             


Leu Met Ala Lys Gln Asp Lys Lys Tyr Leu Asn Asp Asn Phe Leu Lys 
    530                 535                 540                 


Asp Ala Ile Leu Pro Pro Asn Val Lys Val Thr Phe Gln Gln Ala Ile 
545                 550                 555                 560 


Leu Ile Phe Asn Lys Ile Ile Gln Lys Phe Ser Lys Asp Phe Glu Ile 
                565                 570                 575     


Asp Lys Val Val Ile Glu Leu Ala Arg Glu Met Thr Gln Asp Gln Glu 
            580                 585                 590         


Asn Asp Ala Leu Lys Gly Ile Ala Lys Ala Gln Lys Ser Lys Lys Ser 
        595                 600                 605             


Leu Val Glu Glu Arg Leu Glu Ala Asn Asn Ile Asp Lys Ser Val Phe 
    610                 615                 620                 


Asn Asp Lys Tyr Glu Lys Leu Ile Tyr Lys Ile Phe Leu Trp Ile Ser 
625                 630                 635                 640 


Gln Asp Phe Lys Asp Pro Tyr Thr Gly Ala Gln Ile Ser Val Asn Glu 
                645                 650                 655     


Ile Val Asn Asn Lys Val Glu Ile Asp His Ile Ile Pro Tyr Ser Leu 
            660                 665                 670         


Cys Phe Asp Asp Ser Ser Ala Asn Lys Val Leu Val His Lys Gln Ser 
        675                 680                 685             


Asn Gln Glu Lys Ser Asn Ser Leu Pro Tyr Glu Tyr Ile Lys Gln Gly 
    690                 695                 700                 


His Ser Gly Trp Asn Trp Asp Glu Phe Thr Lys Tyr Val Lys Arg Val 
705                 710                 715                 720 


Phe Val Asn Asn Val Asp Ser Ile Leu Ser Lys Lys Glu Arg Leu Lys 
                725                 730                 735     


Lys Ser Glu Asn Leu Leu Thr Ala Ser Tyr Asp Gly Tyr Asp Lys Leu 
            740                 745                 750         


Gly Phe Leu Ala Arg Asn Leu Asn Asp Thr Arg Tyr Ala Thr Ile Leu 
        755                 760                 765             


Phe Arg Asp Gln Leu Asn Asn Tyr Ala Glu His His Leu Ile Asp Asn 
    770                 775                 780                 


Lys Lys Met Phe Lys Val Ile Ala Met Asn Gly Ala Val Thr Ser Phe 
785                 790                 795                 800 


Ile Arg Lys Asn Met Ser Tyr Asp Asn Lys Leu Arg Leu Lys Asp Arg 
                805                 810                 815     


Ser Asp Phe Ser His His Ala Tyr Asp Ala Ala Ile Ile Ala Leu Phe 
            820                 825                 830         


Ser Asn Lys Thr Lys Thr Leu Tyr Asn Leu Ile Asp Pro Ser Leu Asn 
        835                 840                 845             


Gly Ile Ile Ser Lys Arg Ser Glu Gly Tyr Trp Val Ile Glu Asp Arg 
    850                 855                 860                 


Tyr Thr Gly Glu Ile Lys Glu Leu Lys Lys Glu Asp Trp Thr Ser Ile 
865                 870                 875                 880 


Lys Asn Asn Val Gln Ala Arg Lys Ile Ala Lys Glu Ile Glu Glu Tyr 
                885                 890                 895     


Leu Ile Asp Leu Asp Asp Glu Val Phe Phe Ser Arg Lys Thr Lys Arg 
            900                 905                 910         


Lys Thr Asn Arg Gln Leu Tyr Asn Glu Thr Ile Tyr Gly Ile Ala Thr 
        915                 920                 925             


Lys Thr Asp Glu Asp Gly Ile Thr Asn Tyr Tyr Lys Lys Glu Lys Phe 
    930                 935                 940                 


Ser Ile Leu Asp Asp Lys Asp Ile Tyr Leu Arg Leu Leu Arg Glu Arg 
945                 950                 955                 960 


Glu Lys Phe Val Ile Asn Gln Ser Asn Pro Glu Val Ile Asp Gln Ile 
                965                 970                 975     


Ile Glu Ile Ile Glu Ser Tyr Gly Lys Glu Asn Asn Ile Pro Ser Arg 
            980                 985                 990         


Asp Glu Ala Ile Asn Ile Lys Tyr  Thr Lys Asn Lys Ile  Asn Tyr Asn 
        995                 1000                 1005             


Leu Tyr  Leu Lys Gln Tyr Met  Arg Ser Leu Thr Lys  Ser Leu Asp 
    1010                 1015                 1020             


Gln Phe  Ser Glu Glu Phe Ile  Asn Gln Met Ile Ala  Asn Lys Thr 
    1025                 1030                 1035             


Phe Val  Leu Tyr Asn Pro Thr  Lys Asn Thr Thr Arg  Lys Ile Lys 
    1040                 1045                 1050             


Phe Leu  Arg Leu Val Asn Asp  Val Lys Ile Asn Asp  Ile Arg Lys 
    1055                 1060                 1065             


Asn Gln  Val Ile Asn Lys Phe  Asn Gly Lys Asn Asn  Glu Pro Lys 
    1070                 1075                 1080             


Ala Phe  Tyr Glu Asn Ile Asn  Ser Leu Gly Ala Ile  Val Phe Lys 
    1085                 1090                 1095             


Asn Ser  Ala Asn Asn Phe Lys  Thr Leu Ser Ile Asn  Thr Gln Ile 
    1100                 1105                 1110             


Ala Ile  Phe Gly Asp Lys Asn  Trp Asp Ile Glu Asp  Phe Lys Thr 
    1115                 1120                 1125             


Tyr Asn  Met Glu Lys Ile Glu  Lys Tyr Lys Glu Ile  Tyr Gly Ile 
    1130                 1135                 1140             


Asp Lys  Thr Tyr Asn Phe His  Ser Phe Ile Phe Pro  Gly Thr Ile 
    1145                 1150                 1155             


Leu Leu  Asp Lys Gln Asn Lys  Glu Phe Tyr Tyr Ile  Ser Ser Ile 
    1160                 1165                 1170             


Gln Thr  Val Arg Asp Ile Ile  Glu Ile Lys Phe Leu  Asn Lys Ile 
    1175                 1180                 1185             


Glu Phe  Lys Asp Glu Asn Lys  Asn Gln Asp Thr Ser  Lys Thr Pro 
    1190                 1195                 1200             


Lys Arg  Leu Met Phe Gly Ile  Lys Ser Ile Met Asn  Asn Tyr Glu 
    1205                 1210                 1215             


Gln Val  Asp Ile Ser Pro Phe  Gly Ile Asn Lys Lys  Ile Phe Glu 
    1220                 1225                 1230             


<210> 325
<211> 1233
<212> PRT
<213> Mycoplasma canis


<220>
<223> Mycoplasma canis UF31

<400> 325
Met Glu Lys Lys Arg Lys Val Thr Leu Gly Phe Asp Leu Gly Ile Ala 
1               5                   10                  15      


Ser Ile Gly Trp Ala Ile Val Asp Ser Glu Thr Asn Gln Val Tyr Lys 
            20                  25                  30          


Leu Gly Ser Arg Leu Phe Asp Ala Pro Asp Thr Asn Leu Glu Arg Arg 
        35                  40                  45              


Thr Gln Arg Gly Thr Arg Arg Leu Leu Arg Arg Arg Lys Tyr Arg Asn 
    50                  55                  60                  


Gln Lys Phe Tyr Asn Leu Val Lys Arg Thr Glu Val Phe Gly Leu Ser 
65                  70                  75                  80  


Ser Arg Glu Ala Ile Glu Asn Arg Phe Arg Glu Leu Ser Ile Lys Tyr 
                85                  90                  95      


Pro Asn Ile Ile Glu Leu Lys Thr Lys Ala Leu Ser Gln Glu Val Cys 
            100                 105                 110         


Pro Asp Glu Ile Ala Trp Ile Leu His Asp Tyr Leu Lys Asn Arg Gly 
        115                 120                 125             


Tyr Phe Tyr Asp Glu Lys Glu Thr Lys Glu Asp Phe Asp Gln Gln Thr 
    130                 135                 140                 


Val Glu Ser Met Pro Ser Tyr Lys Leu Asn Glu Phe Tyr Lys Lys Tyr 
145                 150                 155                 160 


Gly Tyr Phe Lys Gly Ala Leu Ser Gln Pro Thr Glu Ser Glu Met Lys 
                165                 170                 175     


Asp Asn Lys Asp Leu Lys Glu Ala Phe Phe Phe Asp Phe Ser Asn Lys 
            180                 185                 190         


Glu Trp Leu Lys Glu Ile Asn Tyr Phe Phe Asn Val Gln Lys Asn Ile 
        195                 200                 205             


Leu Ser Glu Thr Phe Ile Glu Glu Phe Lys Lys Ile Phe Ser Phe Thr 
    210                 215                 220                 


Arg Asp Ile Ser Lys Gly Pro Gly Ser Asp Asn Met Pro Ser Pro Tyr 
225                 230                 235                 240 


Gly Ile Phe Gly Glu Phe Gly Asp Asn Gly Gln Gly Gly Arg Tyr Glu 
                245                 250                 255     


His Ile Trp Asp Lys Asn Ile Gly Lys Cys Ser Ile Phe Thr Asn Glu 
            260                 265                 270         


Gln Arg Ala Pro Lys Tyr Leu Pro Ser Ala Leu Ile Phe Asn Phe Leu 
        275                 280                 285             


Asn Glu Leu Ala Asn Ile Arg Leu Tyr Ser Thr Asp Lys Lys Asn Ile 
    290                 295                 300                 


Gln Pro Leu Trp Lys Leu Ser Ser Ile Asp Lys Leu Asn Ile Leu Leu 
305                 310                 315                 320 


Asn Leu Phe Asn Leu Pro Ile Ser Glu Lys Lys Lys Lys Leu Thr Asn 
                325                 330                 335     


Ala Asn Ile Asn Asp Ile Val Lys Lys Glu Ser Thr Lys Ser Ile Met 
            340                 345                 350         


Leu Ser Val Glu Asp Ile Asp Met Ile Lys Asp Glu Trp Ala Gly Lys 
        355                 360                 365             


Glu Pro Asn Val Tyr Gly Val Gly Leu Ser Gly Leu Asn Ile Glu Glu 
    370                 375                 380                 


Ser Ala Lys Glu Asn Lys Phe Lys Phe Gln Asp Leu Lys Ile Leu Asn 
385                 390                 395                 400 


Val Leu Ile Asn Leu Leu Asp Asn Val Gly Ile Lys Phe Glu Phe Lys 
                405                 410                 415     


Asp Arg Asn Asp Ile Ile Lys Asn Leu Glu Leu Leu Asp Asn Leu Tyr 
            420                 425                 430         


Leu Phe Leu Ile Tyr Gln Lys Glu Ser Asn Asn Lys Asp Ser Ser Ile 
        435                 440                 445             


Asp Leu Phe Ile Ala Lys Asn Glu Leu Leu Asn Ile Glu Asn Leu Lys 
    450                 455                 460                 


Leu Lys Leu Lys Glu Phe Leu Leu Gly Ala Gly Asn Glu Phe Glu Asn 
465                 470                 475                 480 


His Asn Ser Lys Thr His Ser Leu Ser Lys Lys Ala Ile Asp Ala Ile 
                485                 490                 495     


Leu Pro Lys Leu Leu Asp Asn Asn Glu Gly Trp Asn Leu Glu Ala Ile 
            500                 505                 510         


Lys Asn Tyr Asp Glu Glu Ile Lys Ser Gln Ile Glu Asp Asn Ser Ser 
        515                 520                 525             


Leu Met Ala Lys Gln Asp Lys Lys Tyr Leu Asn Asp Asn Phe Leu Lys 
    530                 535                 540                 


Asp Ala Ile Leu Pro Pro Asn Val Lys Val Thr Phe Gln Gln Ala Ile 
545                 550                 555                 560 


Leu Ile Phe Asn Lys Ile Ile Gln Lys Phe Ser Lys Asp Phe Glu Ile 
                565                 570                 575     


Asp Lys Val Val Ile Glu Leu Ala Arg Glu Met Thr Gln Asp Gln Glu 
            580                 585                 590         


Asn Asp Ala Leu Lys Gly Ile Ala Lys Ala Gln Lys Ser Lys Lys Ser 
        595                 600                 605             


Leu Val Glu Glu Arg Leu Glu Ala Asn Asn Ile Asp Lys Ser Val Phe 
    610                 615                 620                 


Asn Asp Lys Tyr Glu Lys Leu Ile Tyr Lys Ile Phe Leu Trp Ile Ser 
625                 630                 635                 640 


Gln Asp Phe Lys Asp Pro Tyr Thr Gly Ala Gln Ile Ser Thr Asn Glu 
                645                 650                 655     


Ile Val Asn Asn Lys Val Glu Ile Asp His Ile Ile Pro Tyr Ser Leu 
            660                 665                 670         


Cys Phe Asp Asp Ser Ser Ala Asn Lys Val Leu Val His Lys Gln Ser 
        675                 680                 685             


Asn Gln Glu Lys Ser Asn Ser Leu Pro Tyr Glu Tyr Ile Lys Gln Gly 
    690                 695                 700                 


His Ser Gly Trp Asn Trp Asp Glu Phe Thr Lys Tyr Val Lys Arg Val 
705                 710                 715                 720 


Phe Val Asn Asn Val Asp Ser Ile Leu Ser Lys Lys Glu Arg Leu Lys 
                725                 730                 735     


Lys Ser Glu Asn Leu Leu Thr Thr Ser Tyr Asp Gly Tyr Asp Lys Leu 
            740                 745                 750         


Gly Phe Leu Ala Arg Asn Leu Asn Asp Thr Arg Tyr Ala Thr Ile Leu 
        755                 760                 765             


Phe Arg Asp Gln Leu Asn Asn Tyr Ala Glu His His Leu Ile Asp Asn 
    770                 775                 780                 


Lys Lys Met Phe Lys Val Ile Ala Met Asn Gly Ala Val Thr Ser Phe 
785                 790                 795                 800 


Ile Arg Lys Asn Met Ser Tyr Asp Asn Lys Leu Arg Leu Lys Asp Arg 
                805                 810                 815     


Ser Asp Phe Ser His His Ala Tyr Asp Ala Ala Ile Ile Ala Leu Phe 
            820                 825                 830         


Ser Asn Lys Thr Lys Thr Leu Tyr Asn Leu Ile Asp Pro Ser Leu Asn 
        835                 840                 845             


Gly Ile Ile Ser Lys Arg Ser Glu Gly Tyr Trp Val Ile Glu Asp Arg 
    850                 855                 860                 


Tyr Thr Gly Glu Ile Lys Glu Leu Lys Lys Glu Asp Trp Thr Ser Ile 
865                 870                 875                 880 


Lys Asn Asn Val Gln Ala Arg Lys Ile Ala Lys Glu Ile Glu Glu Tyr 
                885                 890                 895     


Leu Ile Asp Leu Asp Asp Glu Val Phe Phe Ser Arg Lys Thr Lys Arg 
            900                 905                 910         


Lys Thr Asn Arg Gln Leu Tyr Asn Glu Thr Ile Tyr Gly Ile Ala Ala 
        915                 920                 925             


Lys Thr Asp Glu Asp Gly Ile Thr Asn Tyr Tyr Lys Lys Glu Lys Phe 
    930                 935                 940                 


Ser Ile Leu Asp Asp Lys Asp Ile Tyr Leu Arg Leu Leu Arg Glu Arg 
945                 950                 955                 960 


Glu Lys Phe Val Ile Asn Gln Ser Asn Pro Glu Val Ile Asp Gln Ile 
                965                 970                 975     


Ile Glu Ile Ile Glu Ser Tyr Gly Lys Glu Asn Asn Ile Pro Ser Arg 
            980                 985                 990         


Asp Glu Ala Ile Asn Ile Lys Tyr  Thr Lys Asn Lys Ile  Asn Tyr Asn 
        995                 1000                 1005             


Leu Tyr  Leu Lys Gln Tyr Met  Arg Ser Leu Thr Lys  Ser Leu Asp 
    1010                 1015                 1020             


Gln Phe  Ser Glu Glu Phe Ile  Asn Gln Met Ile Ala  Asn Lys Thr 
    1025                 1030                 1035             


Phe Val  Leu Tyr Asn Pro Thr  Lys Asn Thr Thr Arg  Lys Ile Lys 
    1040                 1045                 1050             


Phe Leu  Arg Leu Val Asn Asp  Val Lys Ile Asn Asp  Ile Arg Lys 
    1055                 1060                 1065             


Asn Gln  Val Ile Asn Lys Phe  Asn Gly Lys Asn Asn  Glu Pro Lys 
    1070                 1075                 1080             


Ala Phe  Tyr Glu Asn Ile Asn  Ser Leu Gly Ala Ile  Val Phe Lys 
    1085                 1090                 1095             


Asn Ser  Ala Asn Asn Phe Lys  Thr Leu Ser Ile Asn  Thr Gln Ile 
    1100                 1105                 1110             


Ala Ile  Phe Gly Asp Lys Asn  Trp Asp Ile Glu Asp  Phe Lys Thr 
    1115                 1120                 1125             


Tyr Asn  Met Glu Lys Ile Glu  Lys Tyr Lys Glu Ile  Tyr Gly Ile 
    1130                 1135                 1140             


Asp Lys  Thr Tyr Asn Phe His  Ser Phe Ile Phe Pro  Gly Thr Ile 
    1145                 1150                 1155             


Leu Leu  Asp Lys Gln Asn Lys  Glu Phe Tyr Tyr Ile  Ser Ser Ile 
    1160                 1165                 1170             


Gln Thr  Val Arg Asp Ile Ile  Glu Ile Lys Phe Leu  Asn Lys Ile 
    1175                 1180                 1185             


Glu Phe  Lys Asp Glu Asn Lys  Asn Pro Asp Thr Ser  Lys Thr Pro 
    1190                 1195                 1200             


Lys Arg  Leu Met Phe Gly Ile  Lys Ser Ile Met Asn  Asn Tyr Glu 
    1205                 1210                 1215             


Gln Val  Asp Ile Ser Pro Phe  Gly Ile Asn Lys Lys  Ile Phe Glu 
    1220                 1225                 1230             


<210> 326
<211> 1233
<212> PRT
<213> Mycoplasma canis


<220>
<223> Mycoplasma canis UF33

<400> 326
Met Glu Lys Lys Arg Lys Val Thr Leu Gly Phe Asp Leu Gly Ile Ala 
1               5                   10                  15      


Ser Val Gly Trp Ala Ile Val Asp Ser Glu Thr Asn Gln Val Tyr Lys 
            20                  25                  30          


Leu Gly Ser Arg Leu Phe Asp Ala Pro Asp Thr Asn Leu Glu Arg Arg 
        35                  40                  45              


Thr Gln Arg Gly Thr Arg Arg Leu Leu Arg Arg Arg Lys Tyr Arg Asn 
    50                  55                  60                  


Gln Lys Phe Tyr Asn Leu Val Lys Arg Thr Glu Val Phe Gly Leu Ser 
65                  70                  75                  80  


Ser Arg Glu Ala Ile Glu Asn Arg Phe Arg Glu Leu Ser Ile Lys Tyr 
                85                  90                  95      


Pro Asn Ile Ile Glu Leu Lys Thr Lys Ala Leu Ser Gln Glu Val Cys 
            100                 105                 110         


Pro Asp Glu Ile Ala Trp Ile Leu His Asp Tyr Leu Lys Asn Arg Gly 
        115                 120                 125             


Tyr Phe Tyr Asp Glu Lys Glu Thr Lys Glu Asp Phe Asp Gln Gln Thr 
    130                 135                 140                 


Val Glu Ser Met Pro Ser Tyr Lys Leu Asn Glu Phe Tyr Lys Lys Tyr 
145                 150                 155                 160 


Gly Tyr Phe Lys Gly Ala Leu Ser Gln Pro Thr Glu Ser Glu Met Lys 
                165                 170                 175     


Asp Asn Lys Asp Leu Lys Glu Ala Phe Phe Phe Asp Phe Ser Asn Lys 
            180                 185                 190         


Glu Trp Leu Lys Glu Ile Asn Tyr Phe Phe Asn Val Gln Lys Asn Ile 
        195                 200                 205             


Leu Ser Glu Thr Phe Ile Glu Glu Phe Lys Lys Ile Phe Ser Phe Thr 
    210                 215                 220                 


Arg Asp Ile Ser Lys Gly Pro Gly Ser Asp Asn Met Pro Ser Pro Tyr 
225                 230                 235                 240 


Gly Ile Phe Gly Glu Phe Gly Asp Asn Gly Gln Gly Gly Arg Tyr Glu 
                245                 250                 255     


His Ile Trp Asp Lys Asn Ile Gly Lys Cys Ser Ile Phe Thr Asn Glu 
            260                 265                 270         


Gln Arg Ala Pro Lys Tyr Leu Pro Ser Ala Leu Ile Phe Asn Phe Leu 
        275                 280                 285             


Asn Glu Leu Ala Asn Ile Arg Leu Tyr Ser Thr Asp Lys Lys Asn Ile 
    290                 295                 300                 


Gln Pro Leu Trp Lys Leu Ser Ser Val Asp Lys Leu Asn Ile Leu Leu 
305                 310                 315                 320 


Asn Leu Phe Asn Leu Pro Ile Ser Glu Lys Lys Lys Lys Leu Thr Ser 
                325                 330                 335     


Thr Asn Ile Asn Asp Ile Val Lys Lys Glu Ser Ile Lys Ser Ile Met 
            340                 345                 350         


Ile Ser Val Glu Asp Ile Asp Met Ile Lys Asp Glu Trp Ala Gly Lys 
        355                 360                 365             


Glu Pro Asn Val Tyr Gly Val Gly Leu Ser Gly Leu Asn Ile Glu Glu 
    370                 375                 380                 


Asn Ala Lys Glu Asn Lys Phe Lys Phe Gln Asp Leu Lys Ile Leu Asn 
385                 390                 395                 400 


Val Leu Ile Asn Leu Leu Asp Asn Val Gly Ile Lys Phe Glu Phe Lys 
                405                 410                 415     


Asp Arg Asn Asp Ile Ile Lys Asn Leu Glu Leu Leu Asp Asn Leu Tyr 
            420                 425                 430         


Leu Phe Leu Ile Tyr Gln Lys Glu Ser Asn Asn Lys Asp Ser Ser Ile 
        435                 440                 445             


Asp Leu Phe Ile Ala Lys Asn Lys Ser Leu Asn Ile Glu Asn Leu Lys 
    450                 455                 460                 


Leu Lys Leu Lys Glu Phe Leu Leu Gly Ala Gly Asn Glu Phe Glu Asn 
465                 470                 475                 480 


His Asn Ser Lys Ser His Ser Leu Ser Lys Lys Ala Ile Asp Ala Ile 
                485                 490                 495     


Leu Pro Lys Leu Leu Asp Asn Asn Glu Gly Trp Asn Leu Glu Ala Ile 
            500                 505                 510         


Lys Asn Tyr Asp Glu Glu Ile Lys Ser Gln Ile Glu Asp Asn Ser Ser 
        515                 520                 525             


Leu Met Ala Lys Gln Asp Lys Lys Tyr Leu Asn Asp Asn Phe Leu Lys 
    530                 535                 540                 


Asp Ala Ile Leu Pro Pro Asn Val Lys Val Thr Phe Gln Gln Ala Ile 
545                 550                 555                 560 


Leu Ile Phe Asn Lys Ile Ile Gln Lys Phe Ser Lys Asp Phe Glu Ile 
                565                 570                 575     


Asp Lys Val Val Ile Glu Leu Ala Arg Glu Met Thr Gln Asp Gln Glu 
            580                 585                 590         


Asn Asp Ala Leu Lys Gly Met Ala Lys Ala Gln Lys Ser Lys Lys Ser 
        595                 600                 605             


Leu Val Glu Glu Arg Leu Glu Ala Asn Asn Ile Asp Lys Ser Val Phe 
    610                 615                 620                 


Asn Asp Lys Tyr Glu Lys Leu Ile Tyr Lys Ile Phe Leu Trp Ile Ser 
625                 630                 635                 640 


Gln Asp Phe Lys Asp Pro Tyr Thr Gly Ala Gln Ile Ser Val Asn Glu 
                645                 650                 655     


Ile Val Asn Asn Lys Val Glu Ile Asp His Ile Ile Pro Tyr Ser Leu 
            660                 665                 670         


Cys Phe Asp Asp Ser Ser Ala Asn Lys Val Leu Val His Lys Gln Ser 
        675                 680                 685             


Asn Gln Glu Lys Ser Asn Ser Leu Pro Tyr Glu Tyr Ile Lys Gln Gly 
    690                 695                 700                 


His Ser Gly Trp Asn Trp Asp Glu Phe Thr Lys Tyr Val Lys Arg Val 
705                 710                 715                 720 


Phe Val Asn Asn Val Asp Ser Ile Leu Ser Lys Lys Glu Arg Leu Lys 
                725                 730                 735     


Lys Ser Glu Asn Leu Leu Thr Thr Ser Tyr Asp Gly Tyr Asp Lys Leu 
            740                 745                 750         


Gly Phe Leu Ala Arg Asn Leu Asn Asp Thr Arg Tyr Ala Thr Ile Leu 
        755                 760                 765             


Phe Arg Asp Gln Leu Asn Asn Tyr Ala Glu His His Leu Ile Asp Asn 
    770                 775                 780                 


Lys Lys Met Phe Lys Val Ile Ala Met Asn Gly Ala Val Thr Ser Phe 
785                 790                 795                 800 


Ile Arg Lys Asn Met Ser Tyr Asp Asn Lys Leu Arg Leu Lys Asp Arg 
                805                 810                 815     


Ser Asp Phe Ser His His Ala Tyr Asp Ala Ala Ile Ile Ala Leu Phe 
            820                 825                 830         


Ser Asn Lys Thr Lys Thr Leu Tyr Asn Leu Ile Asp Pro Ser Leu Asn 
        835                 840                 845             


Gly Ile Ile Ser Lys Arg Ser Glu Gly Tyr Trp Val Ile Glu Asp Arg 
    850                 855                 860                 


Tyr Thr Gly Glu Ile Lys Glu Leu Lys Lys Glu Asp Trp Thr Ser Ile 
865                 870                 875                 880 


Lys Asn Asn Val Gln Ala Arg Lys Ile Ala Lys Glu Ile Glu Glu Tyr 
                885                 890                 895     


Leu Ile Asp Leu Asp Asp Glu Val Phe Phe Ser Arg Lys Thr Lys Arg 
            900                 905                 910         


Lys Thr Asn Arg Gln Leu Tyr Asn Glu Thr Ile Tyr Gly Ile Ala Ala 
        915                 920                 925             


Lys Thr Asp Glu Asp Gly Ile Thr Asn Tyr Tyr Lys Lys Glu Lys Phe 
    930                 935                 940                 


Ser Ile Leu Asp Asp Lys Asp Ile Tyr Leu Arg Leu Leu Arg Glu Arg 
945                 950                 955                 960 


Glu Lys Phe Val Ile Asn Gln Ser Asn Pro Glu Val Ile Asp Gln Ile 
                965                 970                 975     


Ile Glu Ile Ile Glu Ser Tyr Gly Lys Glu Asn Asn Ile Pro Ser Arg 
            980                 985                 990         


Asp Glu Ala Ile Asn Ile Lys Tyr  Thr Lys Asn Lys Ile  Asn Tyr Asn 
        995                 1000                 1005             


Leu Tyr  Leu Lys Gln Tyr Met  Arg Ser Leu Thr Lys  Ser Leu Asp 
    1010                 1015                 1020             


Lys Phe  Ser Glu Glu Phe Ile  Asn Gln Met Ile Ala  Asn Lys Thr 
    1025                 1030                 1035             


Phe Val  Leu Tyr Asn Pro Thr  Lys Asn Thr Thr Arg  Lys Ile Lys 
    1040                 1045                 1050             


Phe Leu  Arg Leu Val Asn Asp  Val Lys Ile Asn Asp  Ile Arg Lys 
    1055                 1060                 1065             


Asn Gln  Val Ile Asn Lys Phe  Asn Gly Lys Asn Asn  Glu Pro Lys 
    1070                 1075                 1080             


Ala Phe  Tyr Glu Asn Ile Asn  Ser Leu Gly Ala Ile  Val Phe Lys 
    1085                 1090                 1095             


Asn Ser  Ala Asn Asn Phe Lys  Thr Leu Ser Ile Asn  Thr Gln Ile 
    1100                 1105                 1110             


Ala Ile  Phe Gly Asp Lys Asn  Trp Asp Ile Glu Asp  Phe Lys Thr 
    1115                 1120                 1125             


Tyr Asn  Met Glu Lys Ile Glu  Lys Tyr Lys Glu Ile  Tyr Gly Ile 
    1130                 1135                 1140             


Asp Lys  Thr Tyr Asn Phe His  Ser Phe Ile Phe Pro  Gly Thr Ile 
    1145                 1150                 1155             


Leu Leu  Asp Lys Gln Asn Lys  Glu Phe Tyr Tyr Ile  Ser Ser Ile 
    1160                 1165                 1170             


Gln Thr  Val Arg Asp Ile Ile  Glu Ile Lys Phe Leu  Asn Lys Ile 
    1175                 1180                 1185             


Glu Phe  Lys Asp Glu Asn Lys  Asn Gln Asp Thr Ser  Lys Thr Pro 
    1190                 1195                 1200             


Lys Arg  Leu Met Phe Gly Ile  Lys Ser Ile Met Asn  Asn Tyr Glu 
    1205                 1210                 1215             


Gln Val  Asp Ile Ser Pro Phe  Gly Ile Asn Lys Lys  Ile Phe Glu 
    1220                 1225                 1230             


<210> 327
<211> 1233
<212> PRT
<213> Mycoplasma canis


<220>
<223> Mycoplasma canis UFG1

<400> 327
Met Glu Lys Lys Arg Lys Val Thr Leu Gly Phe Asp Leu Gly Ile Ala 
1               5                   10                  15      


Ser Val Gly Trp Ala Ile Val Asp Ser Glu Thr Asn Gln Val Tyr Lys 
            20                  25                  30          


Leu Gly Ser Arg Leu Phe Asp Ala Pro Asp Thr Asn Leu Glu Arg Arg 
        35                  40                  45              


Thr Gln Arg Gly Thr Arg Arg Leu Leu Arg Arg Arg Lys Tyr Arg Asn 
    50                  55                  60                  


Gln Lys Phe Tyr Asn Leu Val Lys Arg Thr Glu Val Phe Gly Leu Ser 
65                  70                  75                  80  


Ser Arg Glu Ala Ile Glu Asn Arg Phe Arg Glu Leu Ser Ile Lys Tyr 
                85                  90                  95      


Pro Asn Ile Ile Glu Leu Lys Thr Lys Ala Leu Ser Gln Glu Val Cys 
            100                 105                 110         


Pro Asp Glu Ile Ala Trp Ile Leu His Asp Tyr Leu Lys Asn Arg Gly 
        115                 120                 125             


Tyr Phe Tyr Asp Glu Lys Glu Thr Lys Glu Asp Phe Asp Gln Gln Thr 
    130                 135                 140                 


Val Glu Ser Met Pro Ser Tyr Lys Leu Asn Glu Phe Tyr Lys Lys Tyr 
145                 150                 155                 160 


Gly Tyr Phe Lys Gly Ala Leu Ser Gln Pro Thr Glu Ser Glu Met Lys 
                165                 170                 175     


Asp Asn Lys Asp Leu Lys Glu Ala Phe Phe Phe Asp Phe Ser Asn Lys 
            180                 185                 190         


Glu Trp Leu Lys Glu Ile Asn Tyr Phe Phe Asn Val Gln Lys Asn Ile 
        195                 200                 205             


Leu Ser Glu Thr Phe Ile Glu Glu Phe Lys Lys Ile Phe Ser Phe Thr 
    210                 215                 220                 


Arg Asp Ile Ser Lys Gly Pro Gly Ser Asp Asn Met Pro Ser Pro Tyr 
225                 230                 235                 240 


Gly Ile Phe Gly Glu Phe Gly Asp Asn Gly Gln Gly Gly Arg Tyr Glu 
                245                 250                 255     


His Ile Trp Asp Lys Asn Ile Gly Lys Cys Ser Ile Phe Thr Asn Glu 
            260                 265                 270         


Gln Arg Ala Pro Lys Tyr Leu Pro Ser Ala Leu Ile Phe Asn Phe Leu 
        275                 280                 285             


Asn Glu Leu Ala Asn Ile Arg Leu Tyr Ser Thr Asp Lys Lys Asn Ile 
    290                 295                 300                 


Gln Pro Leu Trp Lys Leu Ser Ser Val Asp Lys Leu Asn Ile Leu Leu 
305                 310                 315                 320 


Asn Leu Phe Asn Leu Pro Ile Ser Glu Lys Lys Lys Lys Leu Thr Ser 
                325                 330                 335     


Thr Asn Ile Asn Asp Ile Val Lys Lys Glu Ser Ile Lys Ser Ile Met 
            340                 345                 350         


Leu Ser Val Glu Asp Ile Asp Met Ile Lys Tyr Glu Trp Ala Gly Lys 
        355                 360                 365             


Glu Pro Asn Val Tyr Gly Val Gly Leu Ser Gly Leu Asn Ile Glu Glu 
    370                 375                 380                 


Ser Ala Lys Glu Asn Lys Phe Lys Phe Gln Asp Leu Lys Ile Leu Asn 
385                 390                 395                 400 


Val Leu Ile Asn Leu Leu Asp Asn Val Gly Ile Lys Phe Glu Phe Lys 
                405                 410                 415     


Asp Arg Asn Asp Ile Ile Lys Asn Leu Glu Leu Leu Asp Asn Leu Tyr 
            420                 425                 430         


Leu Phe Leu Ile Tyr Gln Lys Glu Ser Asn Asn Lys Asp Ser Ser Ile 
        435                 440                 445             


Asp Leu Phe Ile Ala Lys Asn Lys Ser Leu Asn Ile Glu Asn Leu Lys 
    450                 455                 460                 


Leu Lys Leu Lys Glu Phe Leu Leu Gly Ala Gly Asn Glu Phe Glu Asn 
465                 470                 475                 480 


His Asn Ser Lys Thr His Ser Leu Ser Lys Lys Ala Ile Asp Ala Ile 
                485                 490                 495     


Leu Pro Lys Leu Leu Asp Asn Asn Glu Gly Trp Asn Leu Glu Ala Ile 
            500                 505                 510         


Lys Asn Tyr Asp Glu Glu Ile Lys Ser Gln Ile Glu Asp Asn Ser Ser 
        515                 520                 525             


Leu Met Ala Lys Gln Asp Lys Lys Tyr Leu Asn Asp Asn Phe Leu Lys 
    530                 535                 540                 


Asp Ala Ile Leu Pro Pro Asn Val Lys Val Thr Phe Gln Gln Ala Ile 
545                 550                 555                 560 


Leu Ile Phe Asn Lys Ile Ile Gln Lys Phe Ser Lys Asp Phe Glu Ile 
                565                 570                 575     


Asp Lys Val Val Ile Glu Leu Ala Arg Glu Met Thr Gln Asp Gln Glu 
            580                 585                 590         


Asn Asp Ala Leu Lys Gly Ile Ala Lys Ala Gln Lys Ser Lys Lys Ser 
        595                 600                 605             


Leu Val Glu Glu Arg Leu Glu Ala Asn Asn Ile Asp Lys Ser Val Phe 
    610                 615                 620                 


Asp Asp Lys Tyr Glu Lys Leu Ile Tyr Lys Ile Phe Leu Trp Ile Ser 
625                 630                 635                 640 


Gln Asp Phe Lys Asp Pro Tyr Thr Gly Ala Lys Ile Ser Ala Asn Glu 
                645                 650                 655     


Ile Val Asn Asn Lys Val Glu Ile Asp His Ile Ile Pro Tyr Ser Leu 
            660                 665                 670         


Cys Phe Asp Asp Ser Ser Ala Asn Lys Val Leu Val His Lys Gln Ser 
        675                 680                 685             


Asn Gln Glu Lys Ser Asn Ser Leu Pro Tyr Glu Tyr Ile Lys Gln Gly 
    690                 695                 700                 


His Ser Gly Trp Asn Trp Asp Glu Phe Thr Lys Tyr Val Lys Arg Val 
705                 710                 715                 720 


Phe Val Asn Asn Val Asp Ser Ile Leu Ser Lys Lys Glu Arg Leu Lys 
                725                 730                 735     


Lys Ser Glu Asn Leu Leu Thr Thr Ser Tyr Asp Gly Tyr Asp Lys Leu 
            740                 745                 750         


Gly Phe Leu Ala Arg Asn Leu Asn Asp Thr Arg Tyr Ala Thr Ile Leu 
        755                 760                 765             


Phe Arg Asp Gln Leu Asn Asn Tyr Ala Glu His His Leu Ile Asp Asn 
    770                 775                 780                 


Lys Lys Met Phe Lys Val Ile Ala Met Asn Gly Ala Val Thr Ser Phe 
785                 790                 795                 800 


Ile Arg Lys Asn Met Ser Tyr Asp Asn Lys Leu Arg Leu Lys Asp Arg 
                805                 810                 815     


Ser Asp Phe Ser His His Ala Tyr Asp Ala Ala Ile Ile Ala Leu Phe 
            820                 825                 830         


Ser Asn Lys Thr Lys Thr Leu Tyr Asn Leu Ile Asp Pro Ser Leu Asn 
        835                 840                 845             


Gly Ile Ile Ser Lys Arg Ser Glu Gly Tyr Trp Val Ile Glu Asp Arg 
    850                 855                 860                 


Tyr Thr Gly Glu Ile Lys Glu Leu Lys Lys Glu Asp Trp Thr Ser Ile 
865                 870                 875                 880 


Lys Asn Asn Val Gln Ala Arg Lys Ile Ala Lys Glu Ile Glu Glu Tyr 
                885                 890                 895     


Leu Ile Asp Leu Asp Asp Glu Val Phe Phe Ser Arg Lys Thr Lys Arg 
            900                 905                 910         


Lys Thr Asn Arg Gln Leu Tyr Asn Glu Thr Ile Tyr Gly Ile Ala Ala 
        915                 920                 925             


Lys Thr Asp Glu Asp Gly Ile Thr Asn Tyr Tyr Lys Lys Glu Lys Phe 
    930                 935                 940                 


Ser Ile Leu Asp Asp Lys Asp Ile Tyr Leu Arg Leu Leu Arg Glu Arg 
945                 950                 955                 960 


Glu Lys Phe Val Ile Asn Gln Ser Asn Pro Glu Val Ile Asp Gln Ile 
                965                 970                 975     


Ile Glu Ile Ile Glu Ser Tyr Gly Lys Glu Asn Asn Ile Pro Ser Arg 
            980                 985                 990         


Asp Glu Ala Ile Asn Ile Lys Tyr  Thr Lys Asn Lys Ile  Asn Tyr Asn 
        995                 1000                 1005             


Leu Tyr  Leu Lys Gln Tyr Met  Arg Ser Leu Thr Lys  Ser Leu Asp 
    1010                 1015                 1020             


Gln Phe  Ser Glu Glu Phe Ile  Asn Gln Met Ile Ala  Asn Lys Thr 
    1025                 1030                 1035             


Phe Val  Leu Tyr Asn Pro Thr  Lys Asn Thr Thr Arg  Lys Ile Lys 
    1040                 1045                 1050             


Phe Leu  Arg Leu Val Asn Asp  Val Lys Ile Asn Asp  Ile Arg Lys 
    1055                 1060                 1065             


Asn Gln  Val Ile Asn Lys Phe  Asn Gly Lys Asn Asn  Glu Pro Lys 
    1070                 1075                 1080             


Ala Phe  Tyr Glu Asn Ile Asn  Ser Leu Gly Ala Ile  Val Phe Lys 
    1085                 1090                 1095             


Asn Ser  Ala Asn Asn Phe Lys  Thr Leu Ser Ile Asn  Thr Gln Ile 
    1100                 1105                 1110             


Ala Ile  Phe Gly Asp Lys Asn  Trp Asp Ile Glu Asp  Phe Lys Thr 
    1115                 1120                 1125             


Tyr Asn  Met Glu Lys Ile Glu  Lys Tyr Lys Glu Ile  Tyr Gly Ile 
    1130                 1135                 1140             


Asp Lys  Thr Tyr Asn Phe His  Ser Phe Ile Phe Pro  Gly Thr Ile 
    1145                 1150                 1155             


Leu Leu  Asp Lys Gln Asn Lys  Glu Phe Tyr Tyr Ile  Ser Ser Ile 
    1160                 1165                 1170             


Gln Thr  Val Arg Asp Ile Ile  Glu Ile Lys Phe Leu  Asn Lys Ile 
    1175                 1180                 1185             


Glu Phe  Lys Asp Glu Asn Lys  Asn Gln Asp Thr Ser  Lys Thr Pro 
    1190                 1195                 1200             


Lys Arg  Leu Met Phe Gly Ile  Lys Ser Ile Met Asn  Asn Tyr Glu 
    1205                 1210                 1215             


Gln Val  Asp Ile Ser Pro Phe  Gly Ile Asn Lys Lys  Ile Phe Glu 
    1220                 1225                 1230             


<210> 328
<211> 1233
<212> PRT
<213> Mycoplasma canis


<220>
<223> Mycoplasma canis UFG4

<400> 328
Met Glu Lys Lys Arg Lys Val Thr Leu Gly Phe Asp Leu Gly Ile Ala 
1               5                   10                  15      


Ser Val Gly Trp Ala Ile Val Asp Ser Glu Thr Asn Gln Val Tyr Lys 
            20                  25                  30          


Leu Gly Ser Arg Leu Phe Asp Ala Pro Asp Thr Asn Leu Glu Arg Arg 
        35                  40                  45              


Thr Gln Arg Gly Thr Arg Arg Leu Leu Arg Arg Arg Lys Tyr Arg Asn 
    50                  55                  60                  


Gln Lys Phe Tyr Asn Leu Val Lys Arg Thr Glu Val Phe Gly Leu Ser 
65                  70                  75                  80  


Ser Arg Glu Ala Ile Glu Asn Arg Phe Arg Glu Leu Ser Ile Lys Tyr 
                85                  90                  95      


Pro Asn Ile Ile Glu Leu Lys Thr Lys Ala Leu Ser Gln Glu Val Cys 
            100                 105                 110         


Pro Asp Glu Ile Ala Trp Ile Leu His Asp Tyr Leu Lys Asn Arg Gly 
        115                 120                 125             


Tyr Phe Tyr Asp Glu Lys Glu Thr Lys Glu Asp Phe Asp Gln Gln Thr 
    130                 135                 140                 


Ile Glu Ser Met Pro Ser Tyr Lys Leu Asn Glu Phe Tyr Lys Lys Tyr 
145                 150                 155                 160 


Gly Tyr Phe Lys Gly Ala Leu Ser Gln Pro Thr Glu Ser Glu Met Lys 
                165                 170                 175     


Asp Asn Lys Asp Leu Lys Glu Ala Phe Phe Phe Asp Phe Ser Asn Lys 
            180                 185                 190         


Glu Trp Leu Lys Glu Ile Asn Tyr Phe Phe Asn Val Gln Lys Asn Ile 
        195                 200                 205             


Leu Ser Glu Thr Phe Ile Glu Glu Phe Lys Lys Ile Phe Ser Phe Thr 
    210                 215                 220                 


Arg Asp Ile Ser Lys Gly Pro Gly Ser Asp Asn Met Pro Ser Pro Tyr 
225                 230                 235                 240 


Gly Ile Phe Gly Glu Phe Gly Asp Asn Gly Gln Gly Gly Arg Tyr Glu 
                245                 250                 255     


His Ile Trp Asp Lys Asn Ile Gly Lys Cys Ser Ile Phe Thr Asn Glu 
            260                 265                 270         


Gln Arg Ala Pro Lys Tyr Leu Pro Ser Ala Leu Ile Phe Asn Phe Leu 
        275                 280                 285             


Asn Glu Leu Ala Asn Ile Arg Leu Tyr Ser Thr Asp Lys Lys Asn Ile 
    290                 295                 300                 


Gln Pro Leu Trp Lys Leu Ser Ser Ile Asp Lys Leu Asn Ile Leu Leu 
305                 310                 315                 320 


Asn Leu Phe Asn Leu Pro Ile Ser Glu Lys Lys Lys Lys Leu Thr Ser 
                325                 330                 335     


Ala Asn Ile Asn Asp Ile Val Lys Lys Glu Ser Thr Lys Ser Ile Met 
            340                 345                 350         


Leu Ser Val Glu Asp Ile Asp Met Ile Lys Asp Glu Trp Ala Gly Lys 
        355                 360                 365             


Glu Pro Asn Val Tyr Gly Val Gly Leu Ser Gly Leu Asn Ile Glu Glu 
    370                 375                 380                 


Ser Ala Lys Glu Asn Lys Phe Lys Phe Gln Asp Leu Lys Ile Leu Asn 
385                 390                 395                 400 


Val Leu Ile Asn Leu Leu Asp Asn Val Gly Ile Lys Phe Glu Phe Lys 
                405                 410                 415     


Asp Arg Asn Asp Ile Ile Lys Asn Leu Glu Leu Leu Asp Asn Leu Tyr 
            420                 425                 430         


Leu Phe Leu Ile Tyr Gln Lys Glu Ser Asn Asn Lys Asp Ser Ser Ile 
        435                 440                 445             


Asp Leu Phe Ile Ala Lys Asn Glu Ser Leu Asn Ile Glu Asn Leu Lys 
    450                 455                 460                 


Leu Lys Leu Lys Glu Phe Leu Leu Gly Ala Gly Asn Glu Phe Glu Asn 
465                 470                 475                 480 


His Asn Ser Lys Thr His Ser Leu Ser Lys Lys Ala Ile Asp Ala Ile 
                485                 490                 495     


Leu Pro Lys Leu Leu Asp Asn Asn Glu Gly Trp Asn Leu Glu Ala Ile 
            500                 505                 510         


Lys Asn Tyr Asp Glu Glu Ile Lys Ser Gln Ile Glu Asp Asn Ser Phe 
        515                 520                 525             


Leu Met Ala Lys Gln Asp Lys Lys Tyr Leu Asn Asp Asn Phe Leu Lys 
    530                 535                 540                 


Asp Ala Ile Leu Pro Pro Asn Val Lys Val Thr Phe Gln Gln Ala Ile 
545                 550                 555                 560 


Leu Ile Phe Asn Lys Ile Ile Gln Lys Phe Ser Lys Asp Phe Glu Ile 
                565                 570                 575     


Asp Lys Val Val Ile Glu Leu Ala Arg Glu Met Thr Gln Asp Gln Glu 
            580                 585                 590         


Asn Asp Ala Leu Lys Gly Ile Ala Lys Ala Gln Lys Ser Lys Lys Ser 
        595                 600                 605             


Leu Val Glu Glu Arg Leu Glu Ala Asn Asn Ile Asp Lys Ser Val Phe 
    610                 615                 620                 


Asn Glu Lys Tyr Glu Lys Leu Ile Tyr Lys Ile Phe Leu Trp Ile Ser 
625                 630                 635                 640 


Gln Asp Phe Lys Asp Pro Tyr Thr Gly Ala Lys Ile Ser Ala Asn Glu 
                645                 650                 655     


Ile Val Asp Asn Lys Val Glu Ile Asp His Ile Ile Pro Tyr Ser Leu 
            660                 665                 670         


Cys Phe Asp Asp Ser Ser Ala Asn Lys Val Leu Val His Lys Gln Ser 
        675                 680                 685             


Asn Gln Glu Lys Ser Asn Ser Leu Pro Tyr Glu Tyr Ile Lys Gln Gly 
    690                 695                 700                 


His Ser Gly Trp Asn Trp Asp Glu Phe Thr Lys Tyr Val Lys Arg Val 
705                 710                 715                 720 


Phe Val Asn Asn Val Asp Ser Ile Leu Ser Lys Lys Glu Arg Leu Lys 
                725                 730                 735     


Lys Ser Glu Asn Leu Leu Thr Thr Ser Tyr Asp Gly Tyr Asp Lys Leu 
            740                 745                 750         


Gly Phe Leu Ala Arg Asn Leu Asn Asp Thr Arg Tyr Ala Thr Ile Leu 
        755                 760                 765             


Phe Arg Asp Gln Leu Asn Asn Tyr Ala Glu His His Leu Ile Asp Asp 
    770                 775                 780                 


Lys Lys Met Phe Lys Val Ile Ala Met Asn Gly Ala Val Thr Ser Phe 
785                 790                 795                 800 


Ile Arg Lys Asn Met Ser Tyr Asp Asn Lys Leu Arg Leu Lys Asn Arg 
                805                 810                 815     


Asn Asp Phe Ser His His Ala Tyr Asp Ala Ala Ile Ile Ala Leu Phe 
            820                 825                 830         


Ser Asn Lys Thr Lys Thr Leu Tyr Asn Leu Ile Asp Pro Ser Leu Asn 
        835                 840                 845             


Gly Ile Ile Ser Lys Arg Ser Glu Gly Tyr Trp Val Ile Glu Asp Arg 
    850                 855                 860                 


Tyr Thr Gly Glu Ile Lys Glu Leu Lys Lys Glu Asp Trp Thr Ser Ile 
865                 870                 875                 880 


Lys Asn Asn Val Gln Ala Arg Lys Ile Ala Lys Glu Ile Glu Glu Tyr 
                885                 890                 895     


Leu Ile Asp Leu Asp Asp Glu Val Phe Phe Ser Arg Lys Thr Lys Arg 
            900                 905                 910         


Lys Thr Asn Arg Gln Leu Tyr Asn Glu Thr Ile Tyr Gly Ile Ala Ala 
        915                 920                 925             


Lys Thr Asp Glu Asp Gly Ile Thr Asn Tyr Tyr Lys Lys Glu Lys Leu 
    930                 935                 940                 


Ser Ile Leu Asp Asp Lys Asp Ile Tyr Leu Arg Leu Leu Arg Glu Arg 
945                 950                 955                 960 


Glu Lys Phe Val Ile Asn Gln Ser Asn Pro Glu Val Ile Asp Gln Ile 
                965                 970                 975     


Ile Glu Ile Ile Glu Ser Tyr Gly Lys Glu Asn Asn Ile Pro Ser Arg 
            980                 985                 990         


Asp Glu Ala Ile Asn Ile Lys Tyr  Thr Lys Asn Lys Ile  Asn Tyr Asn 
        995                 1000                 1005             


Leu Tyr  Leu Lys Gln Tyr Met  Arg Ser Leu Thr Lys  Ser Leu Asp 
    1010                 1015                 1020             


Gln Phe  Ser Glu Glu Phe Ile  Asn Gln Met Ile Ala  Asn Lys Thr 
    1025                 1030                 1035             


Phe Val  Leu Tyr Asn Pro Thr  Lys Asn Thr Thr Arg  Lys Ile Lys 
    1040                 1045                 1050             


Phe Leu  Arg Leu Val Asn Asp  Val Lys Ile Asn Asp  Ile Arg Lys 
    1055                 1060                 1065             


Asn Gln  Val Ile Asn Lys Phe  Asn Gly Lys Asn Asn  Glu Pro Lys 
    1070                 1075                 1080             


Ala Phe  Tyr Glu Asn Ile Asn  Ser Leu Gly Ala Ile  Val Phe Lys 
    1085                 1090                 1095             


Asn Ser  Ala Asn Asn Phe Lys  Thr Leu Ser Ile Asn  Thr Gln Ile 
    1100                 1105                 1110             


Ala Ile  Phe Gly Asp Lys Asn  Trp Asp Ile Glu Asp  Phe Lys Thr 
    1115                 1120                 1125             


Tyr Asn  Met Glu Lys Ile Glu  Lys Tyr Lys Glu Ile  Tyr Gly Ile 
    1130                 1135                 1140             


Asp Lys  Thr Tyr Asn Phe His  Ser Phe Ile Phe Pro  Gly Thr Ile 
    1145                 1150                 1155             


Leu Leu  Asp Lys Gln Asn Lys  Glu Phe Tyr Tyr Ile  Ser Ser Ile 
    1160                 1165                 1170             


Gln Thr  Val Arg Asp Ile Ile  Glu Ile Lys Phe Leu  Asn Lys Ile 
    1175                 1180                 1185             


Glu Phe  Lys Asp Glu Asn Lys  Asn Gln Asp Thr Ser  Lys Thr Pro 
    1190                 1195                 1200             


Lys Arg  Leu Met Phe Gly Ile  Lys Ser Ile Met Asn  Asn Tyr Glu 
    1205                 1210                 1215             


Gln Val  Asp Ile Ser Pro Phe  Gly Ile Asn Lys Lys  Ile Phe Glu 
    1220                 1225                 1230             


<210> 329
<211> 1239
<212> PRT
<213> Mycoplasma cynos

<400> 329
Met Glu Glu Lys Arg Lys Val Thr Leu Gly Phe Asp Leu Gly Val Ala 
1               5                   10                  15      


Ser Val Gly Trp Ala Ile Val Asp Ser Glu Thr Asn Glu Val Tyr Lys 
            20                  25                  30          


Leu Gly Ser Arg Leu Phe Asp Ile Pro Asp Thr Asn Ile Asp Arg Arg 
        35                  40                  45              


Ala Lys Arg Gly Ser Arg Arg Leu Val Arg Arg Arg Ser Tyr Arg Asn 
    50                  55                  60                  


Gln Lys Phe Tyr Asn Leu Ile Lys Arg Thr Lys Thr Phe Gly Phe Leu 
65                  70                  75                  80  


Asp Lys Glu Ala Ile Glu Lys Glu Phe Val Leu Leu Ser Ile Lys Tyr 
                85                  90                  95      


Pro Asn Ile Ile Glu Leu Lys Val Lys Gly Leu Gln Glu Glu Val Ser 
            100                 105                 110         


Lys Ser Glu Ala Val Trp Ile Leu His Asp Tyr Leu Lys Asn Arg Gly 
        115                 120                 125             


Tyr Phe Tyr Asp Asp Lys Glu Glu Lys Asp Asp Leu Glu Asn Pro Ser 
    130                 135                 140                 


Ile Glu Ser Met Pro Ser Tyr Lys Leu Tyr Glu Phe Tyr Lys Glu Tyr 
145                 150                 155                 160 


Gly Tyr Phe Lys Gly Ala Leu Ser Ser Pro Thr Glu Ser Glu Lys Asn 
                165                 170                 175     


Lys Asp Ser Asp Leu Glu Lys Ala Ile Phe Phe Asn Phe Ser Asn Lys 
            180                 185                 190         


Glu Trp Thr Lys Glu Ile Asn His Phe Phe Lys Ile Gln Lys Asn Ile 
        195                 200                 205             


Phe Ser Glu Asp Phe Lys Ala Lys Phe Met Glu Phe Phe Ser Phe Ile 
    210                 215                 220                 


Arg Asp Ile Ser Lys Gly Pro Gly Ser Glu Asn Met Pro Ser Gln Tyr 
225                 230                 235                 240 


Ser Ile Phe Gly Lys Tyr Gly Asp Asp Gly Met Gly Gly Lys Tyr Gln 
                245                 250                 255     


His Ile Trp Asp Lys Asn Ile Gly Lys Cys Ser Ile Phe Lys Asp Lys 
            260                 265                 270         


Val Arg Ala Pro Lys Tyr Leu Pro Ser Ala Leu Phe Phe Asn Leu Leu 
        275                 280                 285             


Asn Glu Leu Ser Asn Ile Arg Leu Tyr Ser Val Asp Lys Arg Glu Lys 
    290                 295                 300                 


Ser Val Leu Trp Arg Leu Ser Ser Lys Asp Lys Ile Asn Ile Ile Leu 
305                 310                 315                 320 


Asn Ile Leu Gln Ile Ile Leu Phe Lys Asn Asp Gly Lys Ile Ser Asn 
                325                 330                 335     


Leu Asp Ile Asn Lys Ile Val Lys Asn Glu Ser Ile Lys Ser Ile Ile 
            340                 345                 350         


Leu Asn Glu Ile Asp Leu Asp Leu Ile Lys Asp Met Trp Phe Glu Lys 
        355                 360                 365             


Glu Pro Asn Val Tyr Gly Ile Gly Leu Ser Gly Leu Asn Ile Glu Glu 
    370                 375                 380                 


Asn Lys Lys Glu Asn Arg Phe Lys Phe Gln Asp Leu Lys Ile Phe Ser 
385                 390                 395                 400 


Val Phe Ile Asp Leu Leu Lys Lys Ser Asn Ile Asn Ile Glu Phe Asn 
                405                 410                 415     


Asn Glu Lys Asp Ile Ile His Asn Leu Lys Leu Leu Asp Glu Leu Tyr 
            420                 425                 430         


Phe Phe Leu Ile Thr Gln Lys Tyr Ser Arg Asp Lys Tyr Gly Ser Ile 
        435                 440                 445             


Lys Lys Phe Ile Leu Asn Asn Lys Ser Phe Asn Ile Asp Asn Leu Asp 
    450                 455                 460                 


Glu Lys Leu Asn Ile Phe Leu Ser Ile Ser Asp Asp Glu Phe Asp Asn 
465                 470                 475                 480 


His Asn Ser Lys Thr His Ser Leu Ser Lys Glu Ala Ile Tyr Phe Ile 
                485                 490                 495     


Phe Pro Lys Leu Leu His Asn Asn Glu Gly Trp Asn Leu Glu Ala Ile 
            500                 505                 510         


Lys Asn Tyr Asp Ile Asp Val Arg Glu Glu Ile Ser Lys His Ser Phe 
        515                 520                 525             


Gly Ile Lys Lys Gln Asp Lys Lys Tyr Leu Asp Asp Ala Phe Leu Asp 
    530                 535                 540                 


Asp Ala Ile Leu Pro Pro Ser Val Lys Val Thr Ile Lys Gln Ser Ile 
545                 550                 555                 560 


Leu Ile Phe Asn Lys Ile Ile Lys Lys Phe Ser Asn Lys Phe Gln Ile 
                565                 570                 575     


Asp Asn Val Val Ile Glu Leu Ala Arg Glu Met Thr Gln Glu Lys Glu 
            580                 585                 590         


Met Asp Ala Gln Lys Ser Leu Asn Arg Leu Lys Lys Ser Arg Lys Lys 
        595                 600                 605             


Ile Ile Glu Glu Arg Leu Asn Ala Asn Asn Ile Asp Ser Lys Met Phe 
    610                 615                 620                 


Arg Asp Lys Thr Gly Glu Ile Ser Pro Asn Tyr Ile Tyr Lys Ile Tyr 
625                 630                 635                 640 


Leu Trp Ile Ser Gln Asn Phe Lys Asp Pro Tyr Thr Gly Glu Asn Ile 
                645                 650                 655     


Ser Ala Asn Asp Ile Leu Lys Asn Asn Val Glu Ile Asp His Ile Ile 
            660                 665                 670         


Pro Tyr Ser Leu Cys Phe Asp Asp Ser Ser Ser Asn Lys Val Leu Val 
        675                 680                 685             


Phe Lys His Ser Asn Gln Ser Lys Gly Asn Phe Leu Pro Phe Asp Met 
    690                 695                 700                 


Ile Ser Thr Phe Ser Glu Asn Ser Val Trp Asn Trp Lys Glu Tyr Thr 
705                 710                 715                 720 


Gln Tyr Val Glu Lys Thr Phe Lys Thr Asn Leu Glu Ser Ile Leu Asp 
                725                 730                 735     


Lys Lys Glu Arg Val Lys Lys Ala Asp Asn Leu Leu Thr Ser Ser Tyr 
            740                 745                 750         


Asp Gly Tyr Asp Lys Leu Gly Phe Leu Ala Arg Asn Leu Asn Asp Thr 
        755                 760                 765             


Arg Tyr Ala Thr Ile Leu Phe Arg Asp Gln Leu Ile Asn Tyr Ser Glu 
    770                 775                 780                 


Asn His Leu Ile Asp Ser Lys Lys Met Phe Lys Val Ile Ala Met Asn 
785                 790                 795                 800 


Gly Gly Val Thr Ser Phe Ile Arg Lys Asn Met Ser Phe Asp Ser Gly 
                805                 810                 815     


Leu Lys Val Lys Asp Arg Ser Ile Phe Ser His His Ala Tyr Asp Ala 
            820                 825                 830         


Ala Ile Ile Ala Leu Phe Ser Asn Lys Thr Lys Ile Leu Tyr Asn Leu 
        835                 840                 845             


Ile Asn Pro Ser Leu Asp Gly Ile Ile Ser Lys Arg Ser Glu Gly Tyr 
    850                 855                 860                 


Trp Val Leu Glu Asp Arg Leu Thr Gly Glu Ile Arg Lys Leu Asn Tyr 
865                 870                 875                 880 


Asn Asp Trp Gln Ser Ile Lys Asn Asn Val Glu Val Lys Lys Ile Ala 
                885                 890                 895     


Arg Glu Ile Glu Ser His Leu Ser Asn Leu Asp Asn Val Val Met Phe 
            900                 905                 910         


Ser Arg Lys Ser Lys Arg Lys Thr Asn Lys Glu Leu Tyr Asn Glu Thr 
        915                 920                 925             


Leu Tyr Gly Ile Ala Thr Arg Ile Asp Glu Asn Gly Ile Lys Asn Tyr 
    930                 935                 940                 


Tyr Lys Lys Glu Lys Phe Asn Ile Leu Glu Asp Glu Asn Ile Tyr Leu 
945                 950                 955                 960 


Arg Leu Leu Asn Glu Arg Glu Asn Phe Ile Ile Asn Arg Ser Asn Pro 
                965                 970                 975     


Glu Val Ile Asp Ala Ile Ile Glu Ile Phe Glu Thr Ile Asp Lys Asn 
            980                 985                 990         


Lys Ile Pro Ala Arg Asp Val Ala  Lys Asn Ile Lys Tyr  Thr Asp Asn 
        995                 1000                 1005             


Lys Ile  Lys Tyr Asn Leu Tyr  Leu Lys Asp Tyr Met  Arg Lys Leu 
    1010                 1015                 1020             


Val Asp  Glu Phe Pro Asp Lys  Phe Arg Lys Asp Phe  Ile Glu Gln 
    1025                 1030                 1035             


Met Ile  Ala Lys Lys Ile Phe  Ile Leu Phe Asn Pro  Ile Lys Asn 
    1040                 1045                 1050             


Thr Thr  Arg Lys Ile Lys Ser  Leu Arg Ser Ile Asn  Asn Asn Lys 
    1055                 1060                 1065             


Ile Glu  Asp Ile Arg Lys Lys  Gln Val Leu Glu Lys  Phe Asn Thr 
    1070                 1075                 1080             


Ala Lys  Asn Glu Pro Arg Ser  Phe Tyr Glu Ser Leu  Asn Ser Leu 
    1085                 1090                 1095             


Gly Ala  Ile Ile Phe Lys Asn  Asn Leu Asn Ile Tyr  Lys Lys Met 
    1100                 1105                 1110             


Ser Ile  Ser Ser Gln Ile Ala  Thr Phe Gly Asp Lys  Asn Trp Lys 
    1115                 1120                 1125             


Ile Asp  Asp Ile Asn Thr Tyr  Asn Lys Glu Lys Leu  Asn Lys Tyr 
    1130                 1135                 1140             


Lys Glu  Ile Tyr Gly Ile Asp  Glu Thr Tyr Asp Phe  Tyr Ser Phe 
    1145                 1150                 1155             


Ile Phe  Pro Gly Thr Ile Leu  Leu Asp Glu Lys Asn  Lys Glu Phe 
    1160                 1165                 1170             


Leu Tyr  Ile Ser Ser Ile Gln  Thr Leu Lys Asp Lys  Ile Glu Leu 
    1175                 1180                 1185             


Lys Phe  Leu Asp Arg Ile Glu  Phe Glu Lys Lys Asn  Val Asn Ser 
    1190                 1195                 1200             


Asn Leu  Lys Pro Lys Ile Lys  Arg Glu Ile Ile Ser  Thr Lys Lys 
    1205                 1210                 1215             


Leu Met  Ser Asp Tyr Lys Ile  Ile Lys Ile Ser Pro  Leu Gly Ile 
    1220                 1225                 1230             


Asn Lys  Lys Ile Phe Glu 
    1235                 


<210> 330
<211> 1269
<212> PRT
<213> Mycoplasma gallisepticum

<400> 330
Met Asn Asn Ser Ile Lys Ser Lys Pro Glu Val Thr Ile Gly Leu Asp 
1               5                   10                  15      


Leu Gly Val Gly Ser Val Gly Trp Ala Ile Val Asp Asn Glu Thr Asn 
            20                  25                  30          


Ile Ile His His Leu Gly Ser Arg Leu Phe Ser Gln Ala Lys Thr Ala 
        35                  40                  45              


Glu Asp Arg Arg Ser Phe Arg Gly Ala Arg Arg Leu Ile Arg Arg Arg 
    50                  55                  60                  


Lys Tyr Lys Leu Lys Arg Phe Ile Asn Leu Ile Trp Lys Tyr Asn Ser 
65                  70                  75                  80  


Tyr Phe Gly Phe Lys Asn Lys Glu Asp Ile Leu Asn Asn Tyr Gln Glu 
                85                  90                  95      


Gln Gln Lys Leu His Asn Thr Val Leu Asn Leu Lys Leu Glu Ala Leu 
            100                 105                 110         


Asn Ala Lys Ile Asp Pro Lys Ala Leu Ser Trp Ile Leu His Asp Tyr 
        115                 120                 125             


Leu Lys Asn Arg Gly His Phe Tyr Glu Asp Asn Arg Asp Phe Asn Val 
    130                 135                 140                 


Tyr Pro Thr Glu Glu Leu Ala Asn Tyr Phe Gly Glu Tyr Gly Tyr Tyr 
145                 150                 155                 160 


Lys Gly Ile Ile Asp Ser Lys Glu Asp Asn Asp Asp Lys Leu Glu Glu 
                165                 170                 175     


Gly Leu Thr Lys Tyr Lys Phe Ser Asn Gln His Trp Leu Glu Glu Ile 
            180                 185                 190         


Lys Lys Val Leu Ser Asn Gln Thr Gly Leu Pro Glu Lys Phe Lys Glu 
        195                 200                 205             


Glu Tyr Glu Ser Leu Phe Ser Tyr Val Arg Asn Tyr Ser Glu Gly Pro 
    210                 215                 220                 


Gly Ser Ile Asn Ser Val Ser Pro Tyr Gly Ile Tyr His Leu Asp Glu 
225                 230                 235                 240 


Lys Glu Gly Lys Val Val Gln Lys Tyr Asn Asn Ile Trp Asp Lys Thr 
                245                 250                 255     


Ile Gly Lys Cys Ser Ile Phe Pro Asp Glu Tyr Arg Ala Pro Lys Asn 
            260                 265                 270         


Ser Pro Ile Ala Met Ile Phe Asn Glu Ile Asn Glu Leu Ser Thr Ile 
        275                 280                 285             


Arg Ser Tyr Ser Ile Tyr Leu Thr Gly Trp Phe Ile Asn Gln Glu Phe 
    290                 295                 300                 


Lys Lys Ala Tyr Leu Asn Lys Leu Leu Asp Leu Leu Ile Lys Thr Asn 
305                 310                 315                 320 


Ser Glu Lys Pro Ile Asp Ala Arg Gln Phe Lys Lys Leu Arg Glu Glu 
                325                 330                 335     


Thr Ile Ala Glu Ser Ile Gly Lys Glu Thr Leu Lys Asp Val Glu Arg 
            340                 345                 350         


Glu Glu Lys Leu Glu Lys Glu Asp His Lys Trp Lys Leu Lys Gly Leu 
        355                 360                 365             


Lys Leu Asn Thr Asn Gly Lys Ile Gln Tyr Asn Asp Leu Ser Ser Leu 
    370                 375                 380                 


Ala Lys Phe Val His Lys Leu Lys Gln His Leu Lys Leu Asp Phe Leu 
385                 390                 395                 400 


Leu Glu Asp Gln Tyr Thr Thr Leu Asp Lys Ile Asn Phe Leu Gln Ser 
                405                 410                 415     


Leu Phe Val Tyr Leu Gly Lys His Leu Arg Tyr Ser Asn Arg Val Asp 
            420                 425                 430         


Ser Ala Asn Leu Lys Glu Phe Ser Asp Ser Asn Lys Leu Phe Glu Arg 
        435                 440                 445             


Val Leu Gln Glu Gln Lys Asp Asp Leu Phe Lys Leu Phe Glu Gln Thr 
    450                 455                 460                 


Asp Lys Asp Asp Glu Lys Ile Leu Ala Gln Thr His Ser Leu Ser Thr 
465                 470                 475                 480 


Lys Ala Met Leu Leu Ala Ile Thr Arg Met Thr Asn Leu Asp Asn Asp 
                485                 490                 495     


Glu Asp Asn Gln Lys Asn Asn Asp Lys Gly Trp Asn Phe Glu Ala Ile 
            500                 505                 510         


Lys Asn Phe Asp Gln Lys Phe Ile Asp Ile Thr Lys Lys Asn Asn Asn 
        515                 520                 525             


Leu Ser Leu Lys Gln Asp Lys Arg Tyr Leu Asp Asp Arg Phe Ile Asn 
    530                 535                 540                 


Asp Ala Ile Leu Ser Pro Gly Val Lys Arg Ile Leu Arg Glu Ala Thr 
545                 550                 555                 560 


Lys Val Phe Asn Ala Ile Leu Lys Gln Phe Ser Glu Glu Tyr Asp Val 
                565                 570                 575     


Thr Lys Val Val Ile Glu Leu Ala Arg Glu Leu Ser Glu Glu Lys Glu 
            580                 585                 590         


Leu Glu Asn Thr Lys Asn Tyr Glu Lys Leu Ile Lys Lys Asn Ser Asp 
        595                 600                 605             


Lys Ile Ser Glu Arg Leu Glu Ala Leu Asp Ile Ala Glu Asp Lys Ile 
    610                 615                 620                 


Glu Asp Ile Leu Lys Ser Pro Thr Lys Ser Tyr Lys Val Leu Leu Trp 
625                 630                 635                 640 


Leu Gln Gln Asp His Ile Asp Pro Tyr Ser Gln Lys Glu Ile Ala Phe 
                645                 650                 655     


Glu Asp Ile Leu Thr Lys Thr Glu Lys Thr Glu Ile Asp His Ile Ile 
            660                 665                 670         


Pro Tyr Ser Ile Ser Phe Asp Asp Ser Ser Ser Asn Lys Leu Leu Val 
        675                 680                 685             


Leu Ala Glu Ser Asn Gln Ala Lys Ser Asn Gln Thr Pro Tyr Glu Phe 
    690                 695                 700                 


Ile Thr Ser Gly Asn Ala Gly Ile Lys Trp Glu Asp Tyr Glu Ala Tyr 
705                 710                 715                 720 


Cys Arg Lys Phe Lys Asp Gly Asp Thr Ser Leu Leu Asp Ser Thr Gln 
                725                 730                 735     


Arg Ser Lys Lys Phe Ala Lys Met Met Lys Thr Asp Thr Ser Ser Lys 
            740                 745                 750         


Tyr Asp Ile Gly Phe Leu Ala Arg Asn Leu Asn Asp Thr Arg Tyr Ala 
        755                 760                 765             


Thr Ile Val Phe Arg Asp Ala Leu Lys Asp Tyr Ala Asn Asn His Leu 
    770                 775                 780                 


Val Glu Asp Lys Pro Met Phe Lys Val Val Cys Ile Asn Gly Gly Val 
785                 790                 795                 800 


Thr Ser Phe Leu Arg Lys Asn Phe Asp Lys Ser Trp Tyr Ala Lys Lys 
                805                 810                 815     


Asp Arg Asp Lys Asn Ile His His Ala Val Asp Ala Ser Ile Ile Ser 
            820                 825                 830         


Ile Phe Ser Asn Glu Thr Lys Thr Leu Phe Asn Gln Leu Thr Gln Phe 
        835                 840                 845             


Ala Asp Tyr Lys Leu Phe Lys Asn Thr Asp Gly Ser Trp Lys Lys Ile 
    850                 855                 860                 


Asp Pro Lys Thr Gly Val Val Thr Glu Val Thr Asp Glu Asn Trp Lys 
865                 870                 875                 880 


Gln Ile Arg Val Arg Asn Gln Val Ser Glu Ile Ala Lys Val Ile Asn 
                885                 890                 895     


Lys Cys Ile Gln Asp Ser Asn Ile Glu Arg Lys Ala Arg Tyr Ser Arg 
            900                 905                 910         


Lys Ile Glu Asn Lys Thr Asn Ile Ser Leu Phe Asn Asp Thr Val Tyr 
        915                 920                 925             


Ser Ala Lys Lys Val Gly Tyr Glu Asp Gln Ile Lys Arg Lys Asn Leu 
    930                 935                 940                 


Lys Thr Leu Asp Ile His Glu Ser Ala Glu Glu Asn Lys Asn Ser Lys 
945                 950                 955                 960 


Val Lys Lys Gln Phe Val Tyr Arg Lys Leu Val Asn Val Ser Leu Leu 
                965                 970                 975     


Asn Asn Asp Lys Leu Ala Asp Leu Phe Ala Glu Lys Glu Asp Ile Leu 
            980                 985                 990         


Met Tyr Arg Ala Asn Pro Trp Val  Ile Asn Leu Ala Glu  Gln Ile Phe 
        995                 1000                 1005             


Asn Glu  Tyr Thr Glu Asn Lys  Lys Ile Lys Ser Gln  Asn Val Phe 
    1010                 1015                 1020             


Glu Lys  Tyr Met Leu Asp Leu  Thr Lys Glu Phe Pro  Glu Lys Phe 
    1025                 1030                 1035             


Ser Glu  Ala Phe Val Lys Ser  Met Leu Arg Asn Lys  Thr Ala Ile 
    1040                 1045                 1050             


Ile Tyr  Asn Val Glu Lys Lys  Val Val His Arg Ile  Lys Arg Leu 
    1055                 1060                 1065             


Lys Ile  Leu Ser Ser Glu Leu  Lys Glu Asn Lys Leu  Ser Asn Val 
    1070                 1075                 1080             


Ile Ile  Arg Ser Lys Asn Glu  Ser Gly Thr Lys Leu  Ser Tyr Gln 
    1085                 1090                 1095             


Asp Thr  Ile Asn Ser Ile Ala  Leu Met Ile Met Arg  Ser Ile Asp 
    1100                 1105                 1110             


Pro Thr  Ala Lys Lys Gln Tyr  Ile Arg Val Pro Leu  Asn Thr Leu 
    1115                 1120                 1125             


Asn Leu  His Leu Gly Asp Gln  Asp Phe Asp Leu His  Asn Ile Asp 
    1130                 1135                 1140             


Ala Tyr  Leu Lys Lys Pro Lys  Phe Val Lys Tyr Leu  Lys Ala Asn 
    1145                 1150                 1155             


Glu Ile  Gly Asp Glu Tyr Lys  Pro Trp Arg Val Leu  Thr Ser Gly 
    1160                 1165                 1170             


Thr Leu  Leu Ile His Lys Lys  Asp Lys Lys Leu Met  Tyr Ile Ser 
    1175                 1180                 1185             


Ser Phe  Gln Asn Leu Lys Asp  Val Ile Glu Ile Lys  Asn Leu Ile 
    1190                 1195                 1200             


Glu Thr  Glu Tyr Lys Glu Asn  Asp Asp Ser Asp Pro  Lys Lys Lys 
    1205                 1210                 1215             


Lys Lys  Ala Asn Arg Phe Leu  Met Thr Leu Ser Thr  Ile Leu Asn 
    1220                 1225                 1230             


Asp Tyr  Ile Leu Leu Asp Ala  Lys Asp Asn Phe Asp  Ile Leu Gly 
    1235                 1240                 1245             


Leu Ser  Lys Asn Arg Ile Asp  Glu Ile Leu Asn Ser  Lys Leu Gly 
    1250                 1255                 1260             


Leu Asp  Lys Ile Thr Lys 
    1265                 


<210> 331
<211> 1224
<212> PRT
<213> Mycoplasma gallisepticum

<400> 331
Met Asn Asn Ser Ile Lys Ser Lys Pro Glu Val Thr Ile Gly Leu Asp 
1               5                   10                  15      


Leu Gly Val Gly Ser Val Gly Trp Ala Ile Val Asp Asn Glu Thr Asn 
            20                  25                  30          


Ile Ile His His Leu Gly Ser Arg Leu Phe Ser Gln Ala Lys Thr Ala 
        35                  40                  45              


Glu Asp Arg Arg Ser Phe Arg Gly Ala Arg Arg Leu Ile Arg Arg Arg 
    50                  55                  60                  


Lys Tyr Lys Leu Lys Arg Phe Ile Asn Leu Ile Trp Lys Tyr Asn Ser 
65                  70                  75                  80  


Tyr Phe Gly Phe Lys Asn Lys Glu Asp Ile Leu Asn Asn Tyr Gln Glu 
                85                  90                  95      


Gln Gln Lys Leu His Asn Thr Val Leu Asn Leu Lys Leu Glu Ala Leu 
            100                 105                 110         


Asn Ala Lys Ile Asp Pro Lys Ala Leu Ser Trp Ile Leu His Asp Tyr 
        115                 120                 125             


Leu Lys Asn Arg Gly His Phe Tyr Glu Asp Asn Arg Asp Phe Asn Val 
    130                 135                 140                 


Tyr Pro Thr Glu Glu Leu Ala Asn Tyr Phe Gly Glu Tyr Gly Tyr Tyr 
145                 150                 155                 160 


Lys Gly Ile Ile Asp Ser Lys Glu Asp Asn Asp Asp Lys Leu Glu Glu 
                165                 170                 175     


Gly Leu Thr Lys Tyr Lys Phe Ser Asn Gln His Trp Leu Glu Glu Ile 
            180                 185                 190         


Lys Lys Val Leu Ser Asn Gln Thr Gly Leu Pro Glu Lys Phe Lys Glu 
        195                 200                 205             


Glu Tyr Glu Ser Leu Phe Ser Tyr Val Arg Asn Tyr Ser Glu Gly Pro 
    210                 215                 220                 


Gly Ser Ile Asn Ser Val Ser Pro Tyr Gly Ile Tyr His Leu Asp Glu 
225                 230                 235                 240 


Lys Glu Gly Lys Val Val Gln Lys Tyr Asn Asn Ile Trp Asp Lys Thr 
                245                 250                 255     


Ile Gly Lys Cys Ser Ile Phe Pro Asp Glu Tyr Arg Ala Pro Lys Asn 
            260                 265                 270         


Ser Pro Ile Ala Met Ile Phe Asn Glu Ile Asn Glu Leu Ser Thr Ile 
        275                 280                 285             


Arg Ser Tyr Ser Ile Tyr Leu Thr Gly Trp Phe Ile Asn Gln Glu Phe 
    290                 295                 300                 


Lys Lys Ala Tyr Leu Asn Lys Leu Leu Asp Leu Leu Ile Lys Thr Asn 
305                 310                 315                 320 


Ser Glu Lys Pro Ile Asp Ala Arg Gln Phe Lys Lys Leu Arg Glu Glu 
                325                 330                 335     


Thr Ile Ala Glu Ser Ile Gly Lys Glu Thr Leu Lys Asp Val Glu Arg 
            340                 345                 350         


Glu Glu Lys Leu Glu Lys Glu Asp His Lys Trp Lys Leu Lys Gly Leu 
        355                 360                 365             


Lys Leu Asn Thr Asn Gly Lys Ile Gln Tyr Asn Asp Leu Ser Ser Leu 
    370                 375                 380                 


Ala Lys Phe Val His Lys Leu Lys Gln His Leu Lys Leu Asp Phe Leu 
385                 390                 395                 400 


Leu Glu Asp Gln Tyr Thr Thr Leu Asp Lys Ile Asn Phe Leu Gln Ser 
                405                 410                 415     


Leu Phe Val Tyr Leu Gly Lys His Leu Arg Tyr Ser Asn Arg Val Asp 
            420                 425                 430         


Ser Ala Asn Leu Lys Glu Phe Ser Asp Ser Asn Lys Leu Phe Glu Arg 
        435                 440                 445             


Val Leu Gln Glu Gln Lys Asp Asp Leu Phe Lys Leu Phe Glu Gln Thr 
    450                 455                 460                 


Asp Lys Asp Asp Glu Lys Ile Leu Ala Gln Thr His Ser Leu Ser Thr 
465                 470                 475                 480 


Lys Ala Met Leu Leu Ala Ile Thr Arg Met Thr Asn Leu Asp Asn Asp 
                485                 490                 495     


Glu Asp Asn Gln Lys Asn Asn Asp Lys Gly Trp Asn Phe Glu Ala Ile 
            500                 505                 510         


Lys Asn Phe Asp Gln Lys Phe Ile Asp Ile Thr Lys Lys Asn Asn Asn 
        515                 520                 525             


Leu Ser Leu Lys Gln Asp Lys Arg Tyr Leu Asp Asp Arg Phe Ile Asn 
    530                 535                 540                 


Asp Ala Ile Leu Ser Pro Gly Val Lys Arg Ile Leu Arg Glu Ala Thr 
545                 550                 555                 560 


Lys Val Phe Asn Ala Ile Leu Lys Gln Phe Ser Glu Glu Tyr Asp Val 
                565                 570                 575     


Thr Lys Val Val Ile Glu Leu Ala Arg Glu Leu Ser Glu Glu Lys Glu 
            580                 585                 590         


Leu Glu Asn Thr Lys Asn Tyr Glu Lys Leu Ile Lys Lys Asn Ser Asp 
        595                 600                 605             


Lys Ile Ser Glu Arg Leu Glu Ala Leu Asp Ile Ala Glu Asp Lys Ile 
    610                 615                 620                 


Glu Asp Ile Leu Lys Ser Pro Thr Lys Ser Tyr Lys Val Leu Leu Trp 
625                 630                 635                 640 


Leu Gln Gln Asp His Ile Asp Pro Tyr Ser Gln Lys Glu Ile Ala Phe 
                645                 650                 655     


Glu Asp Ile Leu Thr Lys Thr Glu Lys Thr Glu Ile Asp His Ile Ile 
            660                 665                 670         


Pro Tyr Ser Ile Ser Phe Asp Asp Ser Ser Ser Asn Lys Leu Leu Val 
        675                 680                 685             


Leu Ala Glu Ser Asn Gln Ala Lys Ser Asn Gln Thr Pro Tyr Glu Phe 
    690                 695                 700                 


Ile Thr Ser Gly Asn Ala Gly Ile Lys Trp Glu Asp Tyr Glu Ala Tyr 
705                 710                 715                 720 


Cys Arg Lys Phe Lys Asp Gly Asp Thr Ser Leu Leu Asp Ser Thr Gln 
                725                 730                 735     


Arg Ser Lys Lys Phe Ala Lys Met Met Lys Thr Asp Thr Ser Ser Lys 
            740                 745                 750         


Tyr Asp Ile Gly Phe Leu Ala Arg Asn Leu Asn Asp Thr Arg Tyr Ala 
        755                 760                 765             


Thr Ile Val Phe Arg Asp Ala Leu Lys Asp Tyr Ala Asn Asn His Leu 
    770                 775                 780                 


Val Glu Asp Lys Pro Met Phe Lys Val Val Cys Ile Asn Gly Gly Val 
785                 790                 795                 800 


Thr Ser Phe Leu Arg Lys Asn Phe Asp Lys Ser Trp Tyr Ala Lys Lys 
                805                 810                 815     


Asp Arg Asp Lys Asn Ile His His Ala Val Asp Ala Ser Ile Ile Ser 
            820                 825                 830         


Ile Phe Ser Asn Glu Thr Lys Thr Leu Phe Asn Gln Leu Thr Gln Phe 
        835                 840                 845             


Ala Asp Tyr Lys Leu Phe Lys Asn Thr Asp Gly Ser Trp Lys Lys Ile 
    850                 855                 860                 


Asp Pro Lys Thr Gly Val Val Thr Glu Val Thr Asp Glu Asn Trp Lys 
865                 870                 875                 880 


Gln Ile Arg Val Arg Asn Gln Val Ser Glu Ile Ala Lys Val Ile Asn 
                885                 890                 895     


Lys Cys Ile Gln Asp Ser Asn Ile Glu Arg Lys Ala Arg Tyr Ser Arg 
            900                 905                 910         


Lys Ile Glu Asn Lys Thr Asn Ile Ser Leu Phe Asn Asp Thr Val Tyr 
        915                 920                 925             


Ser Ala Lys Lys Val Gly Tyr Glu Asp Gln Ile Lys Arg Lys Asn Leu 
    930                 935                 940                 


Lys Thr Leu Asp Ile His Glu Ser Ala Glu Glu Asn Lys Asn Ser Lys 
945                 950                 955                 960 


Val Lys Lys Gln Phe Val Tyr Arg Lys Leu Val Asn Val Ser Leu Leu 
                965                 970                 975     


Asn Asn Asp Lys Leu Ala Asp Leu Phe Ala Glu Lys Glu Asp Ile Leu 
            980                 985                 990         


Met Tyr Arg Ala Asn Pro Trp Val  Ile Asn Leu Ala Glu  Gln Ile Phe 
        995                 1000                 1005             


Asn Glu  Tyr Thr Glu Asn Lys  Lys Ile Lys Ser Gln  Asn Val Phe 
    1010                 1015                 1020             


Glu Lys  Tyr Met Leu Asp Leu  Thr Lys Glu Phe Pro  Glu Lys Phe 
    1025                 1030                 1035             


Ser Glu  Ala Phe Val Lys Ser  Met Leu Arg Asn Lys  Thr Ala Ile 
    1040                 1045                 1050             


Ile Tyr  Asn Val Glu Lys Lys  Val Val His Arg Ile  Lys Arg Leu 
    1055                 1060                 1065             


Lys Ile  Leu Ser Ser Glu Leu  Lys Glu Asn Lys Leu  Ser Asn Val 
    1070                 1075                 1080             


Ile Ile  Arg Ser Lys Asn Glu  Ser Gly Thr Lys Leu  Ser Tyr Gln 
    1085                 1090                 1095             


Asp Thr  Ile Asn Ser Ile Ala  Leu Met Ile Met Arg  Ser Ile Asp 
    1100                 1105                 1110             


Pro Thr  Ala Lys Lys Gln Tyr  Ile Arg Val Pro Leu  Asn Thr Leu 
    1115                 1120                 1125             


Asn Leu  His Leu Gly Asp Gln  Asp Phe Asp Leu His  Asn Ile Asp 
    1130                 1135                 1140             


Ala Tyr  Leu Lys Lys Pro Lys  Phe Val Lys Tyr Leu  Lys Ala Asn 
    1145                 1150                 1155             


Glu Ile  Gly Asp Glu Tyr Lys  Pro Trp Arg Val Leu  Thr Ser Gly 
    1160                 1165                 1170             


Thr Leu  Leu Ile His Lys Lys  Asp Lys Lys Leu Met  Tyr Ile Ser 
    1175                 1180                 1185             


Ser Phe  Gln Asn Leu Lys Asp  Val Ile Glu Ile Lys  Asn Leu Ile 
    1190                 1195                 1200             


Glu Thr  Glu Tyr Lys Glu Asn  Asp Asp Ser Asp Pro  Lys Lys Arg 
    1205                 1210                 1215             


Arg Lys  Gln Ile Gly Ser 
    1220                 


<210> 332
<211> 1269
<212> PRT
<213> Mycoplasma gallisepticum

<400> 332
Met Asn Asn Ser Ile Lys Ser Lys Pro Glu Val Thr Ile Gly Leu Asp 
1               5                   10                  15      


Leu Gly Val Gly Ser Val Gly Trp Ala Ile Val Asp Asn Glu Thr Asn 
            20                  25                  30          


Ile Ile His His Leu Gly Ser Arg Leu Phe Ser Gln Ala Lys Thr Ala 
        35                  40                  45              


Glu Asp Arg Arg Ser Phe Arg Gly Val Arg Arg Leu Ile Arg Arg Arg 
    50                  55                  60                  


Lys Tyr Lys Leu Lys Arg Phe Val Asn Leu Ile Trp Lys Tyr Asn Ser 
65                  70                  75                  80  


Tyr Phe Gly Phe Lys Asn Lys Glu Asp Ile Leu Asn Asn Tyr Gln Glu 
                85                  90                  95      


Gln Gln Lys Leu His Asn Thr Val Leu Asn Leu Lys Ser Glu Ala Leu 
            100                 105                 110         


Asn Ala Lys Ile Asp Pro Lys Ala Leu Ser Trp Ile Leu His Asp Tyr 
        115                 120                 125             


Leu Lys Asn Arg Gly His Phe Tyr Glu Asp Asn Arg Asp Phe Asn Val 
    130                 135                 140                 


Tyr Pro Thr Lys Glu Leu Ala Lys Tyr Phe Asp Lys Tyr Gly Tyr Tyr 
145                 150                 155                 160 


Lys Gly Ile Ile Asp Ser Lys Glu Asp Asn Asp Asn Lys Leu Glu Glu 
                165                 170                 175     


Glu Leu Thr Lys Tyr Lys Phe Ser Asn Lys His Trp Leu Glu Glu Val 
            180                 185                 190         


Lys Lys Val Leu Ser Asn Gln Thr Gly Leu Pro Glu Lys Phe Lys Glu 
        195                 200                 205             


Glu Tyr Glu Ser Leu Phe Ser Tyr Val Arg Asn Tyr Ser Glu Gly Pro 
    210                 215                 220                 


Gly Ser Ile Asn Ser Val Ser Pro Tyr Gly Ile Tyr His Leu Asp Glu 
225                 230                 235                 240 


Lys Glu Gly Lys Val Val Gln Lys Tyr Asn Asn Ile Trp Asp Lys Thr 
                245                 250                 255     


Ile Gly Lys Cys Asn Ile Phe Pro Asp Glu Tyr Arg Ala Pro Lys Asn 
            260                 265                 270         


Ser Pro Ile Ala Met Ile Phe Asn Glu Ile Asn Glu Leu Ser Thr Ile 
        275                 280                 285             


Arg Ser Tyr Ser Ile Tyr Leu Thr Gly Trp Phe Ile Asn Gln Glu Phe 
    290                 295                 300                 


Lys Lys Ala Tyr Leu Asn Lys Leu Leu Asp Leu Leu Ile Lys Thr Asn 
305                 310                 315                 320 


Gly Glu Lys Pro Ile Asp Ala Arg Gln Phe Lys Lys Leu Arg Glu Glu 
                325                 330                 335     


Thr Ile Ala Glu Ser Ile Gly Lys Glu Thr Leu Lys Asp Val Glu Asn 
            340                 345                 350         


Glu Glu Lys Leu Glu Lys Glu Asp His Lys Trp Lys Leu Lys Gly Leu 
        355                 360                 365             


Lys Leu Asn Thr Asn Gly Lys Ile Gln Tyr Asn Asp Leu Ser Ser Leu 
    370                 375                 380                 


Ala Lys Phe Val His Lys Leu Lys Gln His Leu Lys Leu Asp Phe Leu 
385                 390                 395                 400 


Leu Glu Asp Gln Tyr Ala Thr Leu Asp Lys Ile Asn Phe Leu Gln Ser 
                405                 410                 415     


Leu Phe Val Tyr Leu Gly Lys His Leu Arg Tyr Ser Asn Arg Val Asp 
            420                 425                 430         


Ser Ala Asn Leu Lys Glu Phe Ser Asp Ser Asn Lys Leu Phe Glu Arg 
        435                 440                 445             


Ile Leu Gln Lys Gln Lys Asp Gly Leu Phe Lys Leu Phe Glu Gln Thr 
    450                 455                 460                 


Asp Lys Asp Asp Glu Lys Ile Leu Ala Gln Thr His Ser Leu Ser Thr 
465                 470                 475                 480 


Lys Ala Met Leu Leu Ala Ile Thr Arg Met Thr Asn Leu Asp Asn Asp 
                485                 490                 495     


Glu Asp Asn Gln Lys Asn Asn Asp Lys Gly Trp Asn Phe Glu Ala Ile 
            500                 505                 510         


Lys Asn Phe Asp Gln Lys Phe Ile Asp Ile Thr Lys Lys Asn Asn Asn 
        515                 520                 525             


Leu Ser Leu Lys Gln Asn Lys Arg Tyr Leu Asp Asp Arg Phe Ile Asn 
    530                 535                 540                 


Asp Ala Ile Leu Ser Pro Gly Val Lys Arg Ile Leu Arg Glu Ala Thr 
545                 550                 555                 560 


Lys Val Phe Asn Ala Ile Leu Lys Gln Phe Ser Glu Glu Tyr Asp Val 
                565                 570                 575     


Thr Lys Val Val Ile Glu Leu Ala Arg Glu Leu Ser Glu Glu Lys Glu 
            580                 585                 590         


Leu Glu Asn Thr Lys Asn Tyr Lys Lys Leu Ile Lys Lys Asn Gly Asp 
        595                 600                 605             


Lys Ile Ser Glu Gly Leu Lys Ala Leu Gly Ile Ser Glu Asp Glu Ile 
    610                 615                 620                 


Lys Asp Ile Leu Lys Ser Pro Thr Lys Ser Tyr Lys Phe Leu Leu Trp 
625                 630                 635                 640 


Leu Gln Gln Asp His Ile Asp Pro Tyr Ser Leu Lys Glu Ile Ala Phe 
                645                 650                 655     


Asp Asp Ile Phe Thr Lys Thr Glu Lys Phe Glu Ile Asp His Ile Ile 
            660                 665                 670         


Pro Tyr Ser Ile Ser Phe Asp Asp Ser Ser Ser Asn Lys Leu Leu Val 
        675                 680                 685             


Leu Ala Glu Ser Asn Gln Ala Lys Ser Asn Gln Thr Pro Tyr Glu Phe 
    690                 695                 700                 


Ile Ser Ser Gly Asn Ala Gly Ile Lys Trp Glu Asp Tyr Glu Ala Tyr 
705                 710                 715                 720 


Cys Arg Lys Phe Lys Asp Gly Asp Ser Ser Leu Leu Asp Ser Thr Gln 
                725                 730                 735     


Arg Ser Lys Lys Phe Ala Lys Met Met Lys Thr Asp Thr Ser Ser Lys 
            740                 745                 750         


Tyr Asp Ile Gly Phe Leu Ala Arg Asn Leu Asn Asp Thr Arg Tyr Ala 
        755                 760                 765             


Thr Ile Val Phe Arg Asp Ala Leu Glu Asp Tyr Ala Asn Asn His Leu 
    770                 775                 780                 


Val Glu Asp Lys Pro Met Phe Lys Val Val Cys Ile Asn Gly Ser Val 
785                 790                 795                 800 


Thr Ser Phe Leu Arg Lys Asn Phe Asp Asp Ser Ser Tyr Ala Lys Lys 
                805                 810                 815     


Asp Arg Asp Lys Asn Ile His His Ala Val Asp Ala Ser Ile Ile Ser 
            820                 825                 830         


Ile Phe Ser Asn Glu Thr Lys Thr Leu Phe Asn Gln Leu Thr Gln Phe 
        835                 840                 845             


Ala Asp Tyr Lys Leu Phe Lys Asn Thr Asp Gly Ser Trp Lys Lys Ile 
    850                 855                 860                 


Asp Pro Lys Thr Gly Val Val Thr Glu Val Thr Asp Glu Asn Trp Lys 
865                 870                 875                 880 


Gln Ile Arg Val Arg Asn Gln Val Ser Glu Ile Ala Lys Val Ile Glu 
                885                 890                 895     


Lys Tyr Ile Gln Asp Ser Asn Ile Glu Arg Lys Ala Arg Tyr Ser Arg 
            900                 905                 910         


Lys Ile Glu Asn Lys Thr Asn Ile Ser Leu Phe Asn Asp Thr Val Tyr 
        915                 920                 925             


Ser Ala Lys Lys Val Gly Tyr Glu Asp Gln Ile Lys Arg Lys Asn Leu 
    930                 935                 940                 


Lys Thr Leu Asp Ile His Glu Ser Ala Lys Glu Asn Lys Asn Ser Lys 
945                 950                 955                 960 


Val Lys Arg Gln Phe Val Tyr Arg Lys Leu Val Asn Val Ser Leu Leu 
                965                 970                 975     


Asn Asn Asp Lys Leu Ala Asp Leu Phe Ala Glu Lys Glu Asp Ile Leu 
            980                 985                 990         


Met Tyr Arg Ala Asn Pro Trp Val  Ile Asn Leu Ala Glu  Gln Ile Phe 
        995                 1000                 1005             


Asn Glu  Tyr Thr Glu Asn Lys  Lys Ile Lys Ser Gln  Asn Val Phe 
    1010                 1015                 1020             


Glu Lys  Tyr Met Leu Asp Leu  Thr Lys Glu Phe Pro  Glu Lys Phe 
    1025                 1030                 1035             


Ser Glu  Phe Leu Val Lys Ser  Met Leu Arg Asn Lys  Thr Ala Ile 
    1040                 1045                 1050             


Ile Tyr  Asp Asp Lys Lys Asn  Ile Val His Arg Ile  Lys Arg Leu 
    1055                 1060                 1065             


Lys Met  Leu Ser Ser Glu Leu  Lys Glu Asn Lys Leu  Ser Asn Val 
    1070                 1075                 1080             


Ile Ile  Arg Ser Lys Asn Gln  Ser Gly Thr Lys Leu  Ser Tyr Gln 
    1085                 1090                 1095             


Asp Thr  Ile Asn Ser Leu Ala  Leu Met Ile Met Arg  Ser Ile Asp 
    1100                 1105                 1110             


Pro Thr  Ala Lys Lys Gln Tyr  Ile Arg Val Pro Leu  Asn Thr Leu 
    1115                 1120                 1125             


Asn Leu  His Leu Gly Asp His  Asp Phe Asp Leu His  Asn Met Asp 
    1130                 1135                 1140             


Ala Tyr  Leu Lys Lys Pro Lys  Phe Val Lys Tyr Leu  Lys Ala Asn 
    1145                 1150                 1155             


Glu Ile  Gly Asp Glu Tyr Lys  Pro Trp Arg Val Leu  Thr Ser Gly 
    1160                 1165                 1170             


Thr Leu  Leu Ile His Lys Lys  Asp Lys Lys Leu Met  Tyr Ile Ser 
    1175                 1180                 1185             


Ser Phe  Gln Asn Leu Asn Asp  Val Ile Glu Ile Lys  Asn Leu Ile 
    1190                 1195                 1200             


Glu Thr  Glu Tyr Lys Glu Asn  Asp Asp Ser Asp Ser  Lys Lys Lys 
    1205                 1210                 1215             


Lys Lys  Ala Asn Arg Phe Leu  Met Thr Leu Ser Thr  Ile Leu Asn 
    1220                 1225                 1230             


Asp Tyr  Ile Leu Leu Asp Ala  Lys Asp Asn Phe Asp  Ile Leu Gly 
    1235                 1240                 1245             


Leu Ser  Lys Asn Arg Ile Asp  Glu Ile Leu Asn Ser  Lys Leu Gly 
    1250                 1255                 1260             


Leu Asp  Lys Ile Val Lys 
    1265                 


<210> 333
<211> 1269
<212> PRT
<213> Mycoplasma gallisepticum


<220>
<223> Mycoplasma gallisepticum str. F

<400> 333
Met Asn Asn Ser Ile Lys Ser Lys Pro Glu Val Thr Ile Gly Leu Asp 
1               5                   10                  15      


Leu Gly Val Gly Ser Val Gly Trp Ala Ile Val Asp Asn Glu Thr Asn 
            20                  25                  30          


Ile Ile His His Leu Gly Ser Arg Leu Phe Ser Gln Ala Lys Thr Ala 
        35                  40                  45              


Glu Asp Arg Arg Ser Phe Arg Gly Val Arg Arg Leu Ile Arg Arg Arg 
    50                  55                  60                  


Lys Tyr Lys Leu Lys Arg Phe Val Asn Leu Ile Trp Lys Tyr Asn Ser 
65                  70                  75                  80  


Tyr Phe Gly Phe Lys Asn Lys Glu Asp Ile Leu Asn Asn Tyr Gln Glu 
                85                  90                  95      


Gln Gln Lys Leu His Asn Thr Val Leu Asn Leu Lys Ser Glu Ala Leu 
            100                 105                 110         


Asn Ala Lys Ile Asp Pro Lys Ala Leu Ser Trp Ile Leu His Asp Tyr 
        115                 120                 125             


Leu Lys Asn Arg Gly His Phe Tyr Glu Asp Asn Arg Asp Phe Asn Val 
    130                 135                 140                 


Tyr Pro Thr Lys Glu Leu Ala Lys Tyr Phe Asp Lys Tyr Gly Tyr Tyr 
145                 150                 155                 160 


Lys Gly Ile Ile Asp Ser Lys Glu Asp Asn Asp Asn Lys Leu Glu Glu 
                165                 170                 175     


Glu Leu Thr Lys Tyr Lys Phe Ser Asn Lys His Trp Leu Glu Glu Val 
            180                 185                 190         


Lys Lys Val Leu Ser Asn Gln Thr Gly Leu Pro Glu Lys Phe Lys Glu 
        195                 200                 205             


Glu Tyr Glu Ser Leu Phe Ser Tyr Val Arg Asn Tyr Ser Glu Gly Pro 
    210                 215                 220                 


Gly Ser Ile Asn Ser Val Ser Pro Tyr Gly Ile Tyr His Leu Asp Glu 
225                 230                 235                 240 


Lys Glu Gly Lys Val Val Gln Lys Tyr Asn Asn Ile Trp Asp Lys Thr 
                245                 250                 255     


Ile Gly Lys Cys Asn Ile Phe Pro Asp Glu Tyr Arg Ala Pro Lys Asn 
            260                 265                 270         


Ser Pro Ile Ala Met Ile Phe Asn Glu Ile Asn Glu Leu Ser Thr Ile 
        275                 280                 285             


Arg Ser Tyr Ser Ile Tyr Leu Thr Gly Trp Phe Ile Asn Gln Glu Phe 
    290                 295                 300                 


Lys Lys Ala Tyr Leu Asn Lys Leu Leu Asp Leu Leu Ile Lys Thr Asn 
305                 310                 315                 320 


Gly Glu Lys Pro Ile Asp Ala Arg Gln Phe Lys Lys Leu Arg Glu Glu 
                325                 330                 335     


Thr Ile Ala Glu Ser Ile Gly Lys Glu Thr Leu Lys Asp Val Glu Asn 
            340                 345                 350         


Glu Glu Lys Leu Glu Lys Glu Asp His Lys Trp Lys Leu Lys Gly Leu 
        355                 360                 365             


Lys Leu Asn Thr Asn Gly Lys Ile Gln Tyr Asn Asp Leu Ser Ser Leu 
    370                 375                 380                 


Ala Lys Phe Val His Lys Leu Lys Gln His Leu Lys Leu Asp Phe Leu 
385                 390                 395                 400 


Leu Glu Asp Gln Tyr Ala Thr Leu Asp Lys Ile Asn Phe Leu Gln Ser 
                405                 410                 415     


Leu Phe Val Tyr Leu Gly Lys His Leu Arg Tyr Ser Asn Arg Val Asp 
            420                 425                 430         


Ser Ala Asn Leu Lys Glu Phe Ser Asp Ser Asn Lys Leu Phe Glu Arg 
        435                 440                 445             


Ile Leu Gln Lys Gln Lys Asp Gly Leu Phe Lys Leu Phe Glu Gln Thr 
    450                 455                 460                 


Asp Lys Asp Asp Glu Lys Ile Leu Ala Gln Thr His Ser Leu Ser Thr 
465                 470                 475                 480 


Lys Ala Met Leu Leu Ala Ile Thr Arg Met Thr Asn Leu Asp Asn Asp 
                485                 490                 495     


Glu Asp Asn Gln Lys Asn Asn Asp Lys Gly Trp Asn Phe Glu Ala Ile 
            500                 505                 510         


Lys Asn Phe Asp Gln Lys Phe Ile Asp Ile Thr Lys Lys Asn Asn Asn 
        515                 520                 525             


Leu Ser Leu Lys Gln Asn Lys Arg Tyr Leu Asp Asp Arg Phe Ile Asn 
    530                 535                 540                 


Asp Ala Ile Leu Ser Pro Gly Val Lys Arg Ile Leu Arg Glu Ala Thr 
545                 550                 555                 560 


Lys Val Phe Asn Ala Ile Leu Lys Gln Phe Ser Glu Glu Tyr Asp Val 
                565                 570                 575     


Thr Lys Val Val Ile Glu Leu Ala Arg Glu Leu Ser Glu Glu Lys Glu 
            580                 585                 590         


Leu Glu Asn Thr Lys Asn Tyr Lys Lys Leu Ile Lys Lys Asn Gly Asp 
        595                 600                 605             


Lys Ile Ser Glu Gly Leu Lys Ala Leu Gly Ile Ser Glu Asp Glu Ile 
    610                 615                 620                 


Lys Asp Ile Leu Lys Ser Pro Thr Lys Ser Tyr Lys Phe Leu Leu Trp 
625                 630                 635                 640 


Leu Gln Gln Asp His Ile Asp Pro Tyr Ser Leu Lys Glu Ile Ala Phe 
                645                 650                 655     


Asp Asp Ile Phe Thr Lys Thr Glu Lys Phe Glu Ile Asp His Ile Ile 
            660                 665                 670         


Pro Tyr Ser Ile Ser Phe Asp Asp Ser Ser Ser Asn Lys Leu Leu Val 
        675                 680                 685             


Leu Ala Glu Ser Asn Gln Ala Lys Ser Asn Gln Thr Pro Tyr Glu Phe 
    690                 695                 700                 


Ile Ser Ser Gly Asn Ala Gly Ile Lys Trp Glu Asp Tyr Glu Ala Tyr 
705                 710                 715                 720 


Cys Arg Lys Phe Lys Asp Gly Asp Ser Ser Leu Leu Asp Ser Thr Gln 
                725                 730                 735     


Arg Ser Lys Lys Phe Ala Lys Met Met Lys Thr Asp Thr Ser Ser Lys 
            740                 745                 750         


Tyr Asp Ile Gly Phe Leu Ala Arg Asn Leu Asn Asp Thr Arg Tyr Ala 
        755                 760                 765             


Thr Ile Val Phe Arg Asp Ala Leu Glu Asp Tyr Ala Asn Asn His Leu 
    770                 775                 780                 


Val Glu Asp Lys Pro Met Phe Lys Val Val Cys Ile Asn Gly Ser Val 
785                 790                 795                 800 


Thr Ser Phe Leu Arg Lys Asn Phe Asp Asp Ser Ser Tyr Ala Lys Lys 
                805                 810                 815     


Asp Arg Asp Lys Asn Ile His His Ala Val Asp Ala Ser Ile Ile Ser 
            820                 825                 830         


Ile Phe Ser Asn Glu Thr Lys Thr Leu Phe Asn Gln Leu Thr Gln Phe 
        835                 840                 845             


Ala Asp Tyr Lys Leu Phe Lys Asn Thr Asp Gly Ser Trp Lys Lys Ile 
    850                 855                 860                 


Asp Pro Lys Thr Gly Val Val Thr Glu Val Thr Asp Glu Asn Trp Lys 
865                 870                 875                 880 


Gln Ile Arg Val Arg Asn Gln Val Ser Glu Ile Ala Lys Val Ile Glu 
                885                 890                 895     


Lys Tyr Ile Gln Asp Ser Asn Ile Glu Arg Lys Ala Arg Tyr Ser Arg 
            900                 905                 910         


Lys Ile Glu Asn Lys Thr Asn Ile Ser Leu Phe Asn Asp Thr Val Tyr 
        915                 920                 925             


Ser Ala Lys Lys Val Gly Tyr Glu Asp Gln Ile Lys Arg Lys Asn Leu 
    930                 935                 940                 


Lys Thr Leu Asp Ile His Glu Ser Ala Lys Glu Asn Lys Asn Ser Lys 
945                 950                 955                 960 


Val Lys Arg Gln Phe Val Tyr Arg Lys Leu Val Asn Val Ser Leu Leu 
                965                 970                 975     


Asn Asn Asp Lys Leu Ala Asp Leu Phe Ala Glu Lys Glu Asp Ile Leu 
            980                 985                 990         


Met Tyr Arg Ala Asn Pro Trp Val  Ile Asn Leu Ala Glu  Gln Ile Phe 
        995                 1000                 1005             


Asn Glu  Tyr Thr Glu Asn Lys  Lys Ile Lys Ser Gln  Asn Val Phe 
    1010                 1015                 1020             


Glu Lys  Tyr Met Leu Asp Leu  Thr Lys Glu Phe Pro  Glu Lys Phe 
    1025                 1030                 1035             


Ser Glu  Phe Leu Val Lys Ser  Met Leu Arg Asn Lys  Thr Ala Ile 
    1040                 1045                 1050             


Ile Tyr  Asp Asp Lys Lys Asn  Ile Val His Arg Ile  Lys Arg Leu 
    1055                 1060                 1065             


Lys Met  Leu Ser Ser Glu Leu  Lys Glu Asn Lys Leu  Ser Asn Val 
    1070                 1075                 1080             


Ile Ile  Arg Ser Lys Asn Gln  Ser Gly Thr Lys Leu  Ser Tyr Gln 
    1085                 1090                 1095             


Asp Thr  Ile Asn Ser Leu Ala  Leu Met Ile Met Arg  Ser Ile Asp 
    1100                 1105                 1110             


Pro Thr  Ala Lys Lys Gln Tyr  Ile Arg Val Pro Leu  Asn Thr Leu 
    1115                 1120                 1125             


Asn Leu  His Leu Gly Asp His  Asp Phe Asp Leu His  Asn Met Asp 
    1130                 1135                 1140             


Ala Tyr  Leu Lys Lys Pro Lys  Phe Val Lys Tyr Leu  Lys Ala Asn 
    1145                 1150                 1155             


Glu Ile  Gly Asp Glu Tyr Lys  Pro Trp Arg Val Leu  Thr Ser Gly 
    1160                 1165                 1170             


Thr Leu  Leu Ile His Lys Lys  Asp Lys Lys Leu Met  Tyr Ile Ser 
    1175                 1180                 1185             


Ser Phe  Gln Asn Leu Asn Asp  Val Ile Glu Ile Lys  Asn Leu Ile 
    1190                 1195                 1200             


Glu Thr  Glu Tyr Lys Glu Asn  Asp Asp Ser Asp Ser  Lys Lys Lys 
    1205                 1210                 1215             


Lys Lys  Ala Asn Arg Phe Leu  Met Thr Leu Ser Thr  Ile Leu Asn 
    1220                 1225                 1230             


Asp Tyr  Ile Leu Leu Asp Ala  Lys Asp Asn Phe Asp  Ile Leu Gly 
    1235                 1240                 1245             


Leu Ser  Lys Asn Arg Ile Asp  Glu Ile Leu Asn Ser  Lys Leu Gly 
    1250                 1255                 1260             


Leu Asp  Lys Ile Val Lys 
    1265                 


<210> 334
<211> 1270
<212> PRT
<213> Mycoplasma gallisepticum

<400> 334
Met Asn Asn Ser Ile Lys Ser Lys Pro Glu Val Thr Ile Gly Leu Asp 
1               5                   10                  15      


Leu Gly Val Gly Ser Val Gly Trp Ala Ile Val Asp Asn Glu Thr Asn 
            20                  25                  30          


Ile Ile His His Leu Gly Ser Arg Leu Phe Ser Gln Ala Lys Thr Ala 
        35                  40                  45              


Glu Asp Arg Arg Ser Phe Arg Gly Val Arg Arg Leu Ile Arg Arg Arg 
    50                  55                  60                  


Lys Tyr Lys Leu Lys Arg Phe Val Asn Leu Ile Trp Lys Tyr Asn Ser 
65                  70                  75                  80  


Tyr Phe Gly Phe Lys Asn Lys Glu Asp Ile Leu Asn Asn Tyr Gln Glu 
                85                  90                  95      


Gln Gln Lys Leu His Asn Thr Val Leu Asn Leu Lys Leu Glu Ala Leu 
            100                 105                 110         


Asn Ala Lys Ile Asp Pro Lys Ala Leu Ser Trp Ile Leu His Asp Tyr 
        115                 120                 125             


Leu Lys Asn Arg Gly His Phe Tyr Glu Asp Asn Arg Asp Phe Asn Val 
    130                 135                 140                 


Tyr Pro Thr Glu Glu Leu Ala Asn Tyr Phe Asp Glu Phe Gly Tyr Tyr 
145                 150                 155                 160 


Lys Gly Ile Ile Asp Ser Lys Asn Asp Asp Asp Asp Lys Leu Glu Glu 
                165                 170                 175     


Gly Leu Thr Lys Tyr Lys Phe Ser Asn Gln His Trp Leu Glu Glu Val 
            180                 185                 190         


Lys Lys Val Leu Ser Asn Gln Thr Gly Leu Pro Glu Lys Phe Lys Glu 
        195                 200                 205             


Glu Tyr Glu Ser Leu Phe Ser Tyr Val Arg Asn Tyr Ser Glu Gly Pro 
    210                 215                 220                 


Gly Ser Ile Asn Ser Val Ser Pro Tyr Gly Ile Tyr His Leu Asp Glu 
225                 230                 235                 240 


Lys Glu Gly Lys Val Val Gln Lys Tyr Asn Asn Ile Trp Asp Lys Thr 
                245                 250                 255     


Ile Gly Lys Cys Ser Ile Phe Pro Asp Glu Tyr Arg Ala Pro Lys Asn 
            260                 265                 270         


Ser Pro Ile Ala Met Ile Phe Asn Glu Ile Asn Glu Leu Ser Thr Ile 
        275                 280                 285             


Arg Ser Tyr Ser Ile Tyr Leu Thr Gly Trp Phe Ile Asn Gln Glu Phe 
    290                 295                 300                 


Lys Lys Ala Tyr Leu Asn Lys Leu Leu Asp Leu Leu Ile Lys Thr Asn 
305                 310                 315                 320 


Ser Glu Lys Pro Ile Asp Ala Arg Gln Phe Lys Lys Leu Arg Glu Glu 
                325                 330                 335     


Thr Ile Ala Glu Ser Ile Gly Lys Glu Thr Leu Lys Asp Val Glu Ser 
            340                 345                 350         


Glu Glu Lys Leu Glu Lys Asp Asp His Lys Trp Lys Leu Lys Gly Leu 
        355                 360                 365             


Lys Leu Asn Thr Asn Gly Lys Ile Gln Tyr Asn Asp Leu Ser Ser Leu 
    370                 375                 380                 


Ala Lys Phe Val His Lys Leu Lys Gln His Leu Lys Leu Asp Phe Leu 
385                 390                 395                 400 


Leu Glu Asp Gln Tyr Thr Pro Leu Asp Lys Ile Asn Phe Leu Gln Ser 
                405                 410                 415     


Leu Tyr Val Tyr Leu Gly Lys His Leu Arg Tyr Ser Asn Arg Val Asp 
            420                 425                 430         


Ser Ala Asn Leu Lys Glu Phe Ser Asp Ser Ser Arg Leu Phe Glu Arg 
        435                 440                 445             


Val Leu Gln Glu Gln Lys Asp Gly Leu Phe Lys Leu Phe Glu Gln Thr 
    450                 455                 460                 


Asp Lys Asp Asp Glu Lys Ile Leu Thr Gln Thr His Ser Leu Ser Thr 
465                 470                 475                 480 


Lys Ala Met Leu Leu Ala Ile Thr Arg Met Thr Asn Leu Asp Asn Asp 
                485                 490                 495     


Glu Asp Asn Gln Lys Asn Asn Asp Lys Gly Trp Asn Phe Glu Ala Ile 
            500                 505                 510         


Lys Asn Phe Asp Gln Lys Phe Ile Asp Ile Thr Lys Thr Asn Asn Asn 
        515                 520                 525             


Leu Ser Leu Lys Gln Asp Lys Arg Tyr Leu Asp Asp Gln Phe Ile Asn 
    530                 535                 540                 


Asp Ala Ile Leu Ser Pro Gly Val Lys Arg Ile Leu Arg Glu Ala Thr 
545                 550                 555                 560 


Lys Val Phe Asn Ala Ile Leu Lys Gln Phe Ser Glu Glu Tyr Asp Val 
                565                 570                 575     


Thr Lys Val Val Ile Glu Leu Ala Arg Glu Leu Ser Glu Glu Lys Glu 
            580                 585                 590         


Leu Glu Asn Thr Lys Asn Tyr Lys Lys Leu Ile Lys Lys Asn Gly Asp 
        595                 600                 605             


Lys Ile Ser Glu Gly Leu Lys Ala Leu Gly Ile Ala Glu Asp Lys Ile 
    610                 615                 620                 


Glu Glu Ile Leu Lys Ser Pro Thr Lys Ser Tyr Lys Val Leu Leu Trp 
625                 630                 635                 640 


Leu Gln Gln Asp His Ile Asp Pro Tyr Ser Gln Lys Glu Ile Ala Phe 
                645                 650                 655     


Asp Asp Ile Leu Thr Lys Thr Glu Lys Thr Glu Ile Asp His Ile Ile 
            660                 665                 670         


Pro Tyr Ser Ile Ser Phe Asp Asp Ser Ser Ser Asn Lys Leu Leu Val 
        675                 680                 685             


Leu Ala Glu Ser Asn Gln Ala Lys Ser Asn Gln Thr Pro Tyr Glu Phe 
    690                 695                 700                 


Ile Asn Ser Gly Lys Ala Glu Ile Thr Trp Glu Val Tyr Glu Ala Tyr 
705                 710                 715                 720 


Cys His Lys Phe Lys Asn Gly Asp Ser Ser Leu Leu Asp Ser Thr Gln 
                725                 730                 735     


Arg Ser Lys Lys Phe Ala Lys Met Met Lys Thr Asp Thr Ser Ser Lys 
            740                 745                 750         


Tyr Asp Ile Gly Phe Leu Ala Arg Asn Leu Asn Asp Thr Arg Tyr Ala 
        755                 760                 765             


Thr Ile Val Phe Arg Asp Ala Leu Lys Asp Tyr Ala Asn Asn His Leu 
    770                 775                 780                 


Val Glu Asp Lys Pro Met Phe Lys Val Val Cys Ile Asn Gly Gly Val 
785                 790                 795                 800 


Thr Ser Phe Leu Arg Lys Asn Phe Asp Pro Lys Ser Trp Tyr Ala Lys 
                805                 810                 815     


Lys Asp Arg Asp Lys Asn Ile His His Ala Val Asp Ala Ser Ile Ile 
            820                 825                 830         


Ser Ile Phe Ser Asn Glu Thr Lys Thr Leu Phe Asn Gln Leu Thr Lys 
        835                 840                 845             


Phe Ala Asp Tyr Lys Leu Phe Lys Asn Thr Asp Gly Ser Trp Lys Lys 
    850                 855                 860                 


Ile Asp Pro Lys Thr Gly Val Val Ser Glu Val Thr Asp Glu Asn Trp 
865                 870                 875                 880 


Lys Gln Ile Arg Val Arg Asn Gln Val Ser Glu Ile Ala Lys Val Ile 
                885                 890                 895     


Asp Lys Tyr Ile Gln Asp Ser Asn Ile Glu Arg Lys Ala Arg Tyr Ser 
            900                 905                 910         


Arg Lys Ile Glu Asn Lys Thr Asn Ile Ser Leu Phe Asn Asp Thr Val 
        915                 920                 925             


Tyr Ser Ala Lys Lys Val Gly Tyr Glu Asp Gln Ile Lys Arg Lys Asn 
    930                 935                 940                 


Leu Lys Thr Leu Asp Ile His Glu Ser Ala Glu Glu Asn Lys Asn Ser 
945                 950                 955                 960 


Lys Val Lys Lys Gln Phe Val Tyr Arg Lys Leu Val Asn Val Ser Leu 
                965                 970                 975     


Leu Asn Asn Asp Lys Leu Ala Asp Leu Phe Ala Glu Lys Glu Asp Ile 
            980                 985                 990         


Leu Met Tyr Arg Ala Asn Pro Trp  Val Ile Asn Leu Ala  Glu Gln Ile 
        995                 1000                 1005             


Phe Asn  Glu Tyr Thr Glu Asn  Lys Lys Ile Lys Ser  Gln Asn Val 
    1010                 1015                 1020             


Phe Glu  Lys Tyr Met Leu Asp  Leu Thr Lys Glu Phe  Pro Glu Lys 
    1025                 1030                 1035             


Phe Ser  Glu Ala Phe Val Lys  Ser Met Ile Arg Asn  Lys Thr Ala 
    1040                 1045                 1050             


Ile Ile  Tyr Asn Val Glu Lys  Asp Val Val His Arg  Ile Lys Arg 
    1055                 1060                 1065             


Leu Lys  Ile Leu Ser Ser Glu  Leu Lys Glu Asn Lys  Trp Ser Asn 
    1070                 1075                 1080             


Val Ile  Ile Arg Ser Lys Asn  Glu Ser Gly Thr Lys  Leu Ser Tyr 
    1085                 1090                 1095             


Gln Asp  Thr Ile Asn Ser Ile  Ala Leu Met Ile Met  Arg Ser Ile 
    1100                 1105                 1110             


Asp Pro  Thr Ala Lys Lys Gln  Tyr Ile Arg Val Pro  Leu Asn Thr 
    1115                 1120                 1125             


Leu Asn  Leu His Leu Gly Asp  Gln Asp Phe Asp Leu  His Asn Ile 
    1130                 1135                 1140             


Asp Ala  Tyr Leu Lys Lys Pro  Lys Phe Val Lys Tyr  Leu Lys Ala 
    1145                 1150                 1155             


Asn Glu  Ile Gly Asp Glu Tyr  Lys Pro Trp Arg Val  Leu Thr Ser 
    1160                 1165                 1170             


Gly Thr  Leu Leu Ile His Lys  Lys Asp Lys Lys Leu  Met Tyr Ile 
    1175                 1180                 1185             


Ser Ser  Phe Gln Asn Leu Asn  Asp Leu Ile Glu Ile  Lys Asn Leu 
    1190                 1195                 1200             


Ile Glu  Thr Glu Tyr Lys Glu  Asn Val Asp Ser Asp  Pro Lys Lys 
    1205                 1210                 1215             


Lys Lys  Lys Ala Ser Gln Ile  Leu Arg Ser Leu Ser  Val Ile Leu 
    1220                 1225                 1230             


Asn Asp  Tyr Ile Leu Leu Asp  Ala Lys Tyr Asn Phe  Asp Ile Leu 
    1235                 1240                 1245             


Gly Leu  Ser Lys Asn Lys Ile  Asp Glu Ile Leu Asn  Ser Lys Leu 
    1250                 1255                 1260             


Asp Leu  Asp Lys Ile Ala Lys  
    1265                 1270 


<210> 335
<211> 1236
<212> PRT
<213> Mycoplasma mobile

<400> 335
Met Tyr Phe Tyr Lys Asn Lys Glu Asn Lys Leu Asn Lys Lys Val Val 
1               5                   10                  15      


Leu Gly Leu Asp Leu Gly Ile Ala Ser Val Gly Trp Cys Leu Thr Asp 
            20                  25                  30          


Ile Ser Gln Lys Glu Asp Asn Lys Phe Pro Ile Ile Leu His Gly Val 
        35                  40                  45              


Arg Leu Phe Glu Thr Val Asp Asp Ser Asp Asp Lys Leu Leu Asn Glu 
    50                  55                  60                  


Thr Arg Arg Lys Lys Arg Gly Gln Arg Arg Arg Asn Arg Arg Leu Phe 
65                  70                  75                  80  


Thr Arg Lys Arg Asp Phe Ile Lys Tyr Leu Ile Asp Asn Asn Ile Ile 
                85                  90                  95      


Glu Leu Glu Phe Asp Lys Asn Pro Lys Ile Leu Val Arg Asn Phe Ile 
            100                 105                 110         


Glu Lys Tyr Ile Asn Pro Phe Ser Lys Asn Leu Glu Leu Lys Tyr Lys 
        115                 120                 125             


Ser Val Thr Asn Leu Pro Ile Gly Phe His Asn Leu Arg Lys Ala Ala 
    130                 135                 140                 


Ile Asn Glu Lys Tyr Lys Leu Asp Lys Ser Glu Leu Ile Val Leu Leu 
145                 150                 155                 160 


Tyr Phe Tyr Leu Ser Leu Arg Gly Ala Phe Phe Asp Asn Pro Glu Asp 
                165                 170                 175     


Thr Lys Ser Lys Glu Met Asn Lys Asn Glu Ile Glu Ile Phe Asp Lys 
            180                 185                 190         


Asn Glu Ser Ile Lys Asn Ala Glu Phe Pro Ile Asp Lys Ile Ile Glu 
        195                 200                 205             


Phe Tyr Lys Ile Ser Gly Lys Ile Arg Ser Thr Ile Asn Leu Lys Phe 
    210                 215                 220                 


Gly His Gln Asp Tyr Leu Lys Glu Ile Lys Gln Val Phe Glu Lys Gln 
225                 230                 235                 240 


Asn Ile Asp Phe Met Asn Tyr Glu Lys Phe Ala Met Glu Glu Lys Ser 
                245                 250                 255     


Phe Phe Ser Arg Ile Arg Asn Tyr Ser Glu Gly Pro Gly Asn Glu Lys 
            260                 265                 270         


Ser Phe Ser Lys Tyr Gly Leu Tyr Ala Asn Glu Asn Gly Asn Pro Glu 
        275                 280                 285             


Leu Ile Ile Asn Glu Lys Gly Gln Lys Ile Tyr Thr Lys Ile Phe Lys 
    290                 295                 300                 


Thr Leu Trp Glu Ser Lys Ile Gly Lys Cys Ser Tyr Asp Lys Lys Leu 
305                 310                 315                 320 


Tyr Arg Ala Pro Lys Asn Ser Phe Ser Ala Lys Val Phe Asp Ile Thr 
                325                 330                 335     


Asn Lys Leu Thr Asp Trp Lys His Lys Asn Glu Tyr Ile Ser Glu Arg 
            340                 345                 350         


Leu Lys Arg Lys Ile Leu Leu Ser Arg Phe Leu Asn Lys Asp Ser Lys 
        355                 360                 365             


Ser Ala Val Glu Lys Ile Leu Lys Glu Glu Asn Ile Lys Phe Glu Asn 
    370                 375                 380                 


Leu Ser Glu Ile Ala Tyr Asn Lys Asp Asp Asn Lys Ile Asn Leu Pro 
385                 390                 395                 400 


Ile Ile Asn Ala Tyr His Ser Leu Thr Thr Ile Phe Lys Lys His Leu 
                405                 410                 415     


Ile Asn Phe Glu Asn Tyr Leu Ile Ser Asn Glu Asn Asp Leu Ser Lys 
            420                 425                 430         


Leu Met Ser Phe Tyr Lys Gln Gln Ser Glu Lys Leu Phe Val Pro Asn 
        435                 440                 445             


Glu Lys Gly Ser Tyr Glu Ile Asn Gln Asn Asn Asn Val Leu His Ile 
    450                 455                 460                 


Phe Asp Ala Ile Ser Asn Ile Leu Asn Lys Phe Ser Thr Ile Gln Asp 
465                 470                 475                 480 


Arg Ile Arg Ile Leu Glu Gly Tyr Phe Glu Phe Ser Asn Leu Lys Lys 
                485                 490                 495     


Asp Val Lys Ser Ser Glu Ile Tyr Ser Glu Ile Ala Lys Leu Arg Glu 
            500                 505                 510         


Phe Ser Gly Thr Ser Ser Leu Ser Phe Gly Ala Tyr Tyr Lys Phe Ile 
        515                 520                 525             


Pro Asn Leu Ile Ser Glu Gly Ser Lys Asn Tyr Ser Thr Ile Ser Tyr 
    530                 535                 540                 


Glu Glu Lys Ala Leu Gln Asn Gln Lys Asn Asn Phe Ser His Ser Asn 
545                 550                 555                 560 


Leu Phe Glu Lys Thr Trp Val Glu Asp Leu Ile Ala Ser Pro Thr Val 
                565                 570                 575     


Lys Arg Ser Leu Arg Gln Thr Met Asn Leu Leu Lys Glu Ile Phe Lys 
            580                 585                 590         


Tyr Ser Glu Lys Asn Asn Leu Glu Ile Glu Lys Ile Val Val Glu Val 
        595                 600                 605             


Thr Arg Ser Ser Asn Asn Lys His Glu Arg Lys Lys Ile Glu Gly Ile 
    610                 615                 620                 


Asn Lys Tyr Arg Lys Glu Lys Tyr Glu Glu Leu Lys Lys Val Tyr Asp 
625                 630                 635                 640 


Leu Pro Asn Glu Asn Thr Thr Leu Leu Lys Lys Leu Trp Leu Leu Arg 
                645                 650                 655     


Gln Gln Gln Gly Tyr Asp Ala Tyr Ser Leu Arg Lys Ile Glu Ala Asn 
            660                 665                 670         


Asp Val Ile Asn Lys Pro Trp Asn Tyr Asp Ile Asp His Ile Val Pro 
        675                 680                 685             


Arg Ser Ile Ser Phe Asp Asp Ser Phe Ser Asn Leu Val Ile Val Asn 
    690                 695                 700                 


Lys Leu Asp Asn Ala Lys Lys Ser Asn Asp Leu Ser Ala Lys Gln Phe 
705                 710                 715                 720 


Ile Glu Lys Ile Tyr Gly Ile Glu Lys Leu Lys Glu Ala Lys Glu Asn 
                725                 730                 735     


Trp Gly Asn Trp Tyr Leu Arg Asn Ala Asn Gly Lys Ala Phe Asn Asp 
            740                 745                 750         


Lys Gly Lys Phe Ile Lys Leu Tyr Thr Ile Asp Asn Leu Asp Glu Phe 
        755                 760                 765             


Asp Asn Ser Asp Phe Ile Asn Arg Asn Leu Ser Asp Thr Ser Tyr Ile 
    770                 775                 780                 


Thr Asn Ala Leu Val Asn His Leu Thr Phe Ser Asn Ser Lys Tyr Lys 
785                 790                 795                 800 


Tyr Ser Val Val Ser Val Asn Gly Lys Gln Thr Ser Asn Leu Arg Asn 
                805                 810                 815     


Gln Ile Ala Phe Val Gly Ile Lys Asn Asn Lys Glu Thr Glu Arg Glu 
            820                 825                 830         


Trp Lys Arg Pro Glu Gly Phe Lys Ser Ile Asn Ser Asn Asp Phe Leu 
        835                 840                 845             


Ile Arg Glu Glu Gly Lys Asn Asp Val Lys Asp Asp Val Leu Ile Lys 
    850                 855                 860                 


Asp Arg Ser Phe Asn Gly His His Ala Glu Asp Ala Tyr Phe Ile Thr 
865                 870                 875                 880 


Ile Ile Ser Gln Tyr Phe Arg Ser Phe Lys Arg Ile Glu Arg Leu Asn 
                885                 890                 895     


Val Asn Tyr Arg Lys Glu Thr Arg Glu Leu Asp Asp Leu Glu Lys Asn 
            900                 905                 910         


Asn Ile Lys Phe Lys Glu Lys Ala Ser Phe Asp Asn Phe Leu Leu Ile 
        915                 920                 925             


Asn Ala Leu Asp Glu Leu Asn Glu Lys Leu Asn Gln Met Arg Phe Ser 
    930                 935                 940                 


Arg Met Val Ile Thr Lys Lys Asn Thr Gln Leu Phe Asn Glu Thr Leu 
945                 950                 955                 960 


Tyr Ser Gly Lys Tyr Asp Lys Gly Lys Asn Thr Ile Lys Lys Val Glu 
                965                 970                 975     


Lys Leu Asn Leu Leu Asp Asn Arg Thr Asp Lys Ile Lys Lys Ile Glu 
            980                 985                 990         


Glu Phe Phe Asp Glu Asp Lys Leu  Lys Glu Asn Glu Leu  Thr Lys Leu 
        995                 1000                 1005             


His Ile  Phe Asn His Asp Lys  Asn Leu Tyr Glu Thr  Leu Lys Ile 
    1010                 1015                 1020             


Ile Trp  Asn Glu Val Lys Ile  Glu Ile Lys Asn Lys  Asn Leu Asn 
    1025                 1030                 1035             


Glu Lys  Asn Tyr Phe Lys Tyr  Phe Val Asn Lys Lys  Leu Gln Glu 
    1040                 1045                 1050             


Gly Lys  Ile Ser Phe Asn Glu  Trp Val Pro Ile Leu  Asp Asn Asp 
    1055                 1060                 1065             


Phe Lys  Ile Ile Arg Lys Ile  Arg Tyr Ile Lys Phe  Ser Ser Glu 
    1070                 1075                 1080             


Glu Lys  Glu Thr Asp Glu Ile  Ile Phe Ser Gln Ser  Asn Phe Leu 
    1085                 1090                 1095             


Lys Ile  Asp Gln Arg Gln Asn  Phe Ser Phe His Asn  Thr Leu Tyr 
    1100                 1105                 1110             


Trp Val  Gln Ile Trp Val Tyr  Lys Asn Gln Lys Asp  Gln Tyr Cys 
    1115                 1120                 1125             


Phe Ile  Ser Ile Asp Ala Arg  Asn Ser Lys Phe Glu  Lys Asp Glu 
    1130                 1135                 1140             


Ile Lys  Ile Asn Tyr Glu Lys  Leu Lys Thr Gln Lys  Glu Lys Leu 
    1145                 1150                 1155             


Gln Ile  Ile Asn Glu Glu Pro  Ile Leu Lys Ile Asn  Lys Gly Asp 
    1160                 1165                 1170             


Leu Phe  Glu Asn Glu Glu Lys  Glu Leu Phe Tyr Ile  Val Gly Arg 
    1175                 1180                 1185             


Asp Glu  Lys Pro Gln Lys Leu  Glu Ile Lys Tyr Ile  Leu Gly Lys 
    1190                 1195                 1200             


Lys Ile  Lys Asp Gln Lys Gln  Ile Gln Lys Pro Val  Lys Lys Tyr 
    1205                 1210                 1215             


Phe Pro  Asn Trp Lys Lys Val  Asn Leu Thr Tyr Met  Gly Glu Ile 
    1220                 1225                 1230             


Phe Lys  Lys 
    1235     


<210> 336
<211> 1265
<212> PRT
<213> Mycoplasma ovipneumoniae


<220>
<223> Mycoplasma ovipneumoniae SC01

<400> 336
Met His Asn Lys Lys Asn Ile Thr Ile Gly Phe Asp Leu Gly Ile Ala 
1               5                   10                  15      


Ser Ile Gly Trp Ala Ile Ile Asp Ser Thr Thr Ser Lys Ile Leu Asp 
            20                  25                  30          


Trp Gly Thr Arg Thr Phe Glu Glu Arg Lys Thr Ala Asn Glu Arg Arg 
        35                  40                  45              


Ala Phe Arg Ser Thr Arg Arg Asn Ile Arg Arg Lys Ala Tyr Arg Asn 
    50                  55                  60                  


Gln Arg Phe Ile Asn Leu Ile Leu Lys Tyr Lys Asp Leu Phe Glu Leu 
65                  70                  75                  80  


Lys Asn Ile Ser Asp Ile Gln Arg Ala Asn Lys Lys Asp Thr Glu Asn 
                85                  90                  95      


Tyr Glu Lys Ile Ile Ser Phe Phe Thr Glu Ile Tyr Lys Lys Cys Ala 
            100                 105                 110         


Ala Lys His Ser Asn Ile Leu Glu Val Lys Val Lys Ala Leu Asp Ser 
        115                 120                 125             


Lys Ile Glu Lys Leu Asp Leu Ile Trp Ile Leu His Asp Tyr Leu Glu 
    130                 135                 140                 


Asn Arg Gly Phe Phe Tyr Asp Leu Glu Glu Glu Asn Val Ala Asp Lys 
145                 150                 155                 160 


Tyr Glu Gly Ile Glu His Pro Ser Ile Leu Leu Tyr Asp Phe Phe Lys 
                165                 170                 175     


Lys Asn Gly Phe Phe Lys Ser Asn Ser Ser Ile Pro Lys Asp Leu Gly 
            180                 185                 190         


Gly Tyr Ser Phe Ser Asn Leu Gln Trp Val Asn Glu Ile Lys Lys Leu 
        195                 200                 205             


Phe Glu Val Gln Glu Ile Asn Pro Glu Phe Ser Glu Lys Phe Leu Asn 
    210                 215                 220                 


Leu Phe Thr Ser Val Arg Asp Tyr Ala Lys Gly Pro Gly Ser Glu His 
225                 230                 235                 240 


Ser Ala Ser Glu Tyr Gly Ile Phe Gln Lys Asp Glu Lys Gly Lys Val 
                245                 250                 255     


Phe Lys Lys Tyr Asp Asn Ile Trp Asp Lys Thr Ile Gly Lys Cys Ser 
            260                 265                 270         


Phe Phe Val Glu Glu Asn Arg Ser Pro Val Asn Tyr Pro Ser Tyr Glu 
        275                 280                 285             


Ile Phe Asn Leu Leu Asn Gln Leu Ile Asn Leu Ser Thr Asp Leu Lys 
    290                 295                 300                 


Thr Thr Asn Lys Lys Ile Trp Gln Leu Ser Ser Asn Asp Arg Asn Glu 
305                 310                 315                 320 


Leu Leu Asp Glu Leu Leu Lys Val Lys Glu Lys Ala Lys Ile Ile Ser 
                325                 330                 335     


Ile Ser Leu Lys Lys Asn Glu Ile Lys Lys Ile Ile Leu Lys Asp Phe 
            340                 345                 350         


Gly Phe Glu Lys Ser Asp Ile Asp Asp Gln Asp Thr Ile Glu Gly Arg 
        355                 360                 365             


Lys Ile Ile Lys Glu Glu Pro Thr Thr Lys Leu Glu Val Thr Lys His 
    370                 375                 380                 


Leu Leu Ala Thr Ile Tyr Ser His Ser Ser Asp Ser Asn Trp Ile Asn 
385                 390                 395                 400 


Ile Asn Asn Ile Leu Glu Phe Leu Pro Tyr Leu Asp Ala Ile Cys Ile 
                405                 410                 415     


Ile Leu Asp Arg Glu Lys Ser Arg Gly Gln Asp Glu Val Leu Lys Lys 
            420                 425                 430         


Leu Thr Glu Lys Asn Ile Phe Glu Val Leu Lys Ile Asp Arg Glu Lys 
        435                 440                 445             


Gln Leu Asp Phe Val Lys Ser Ile Phe Ser Asn Thr Lys Phe Asn Phe 
    450                 455                 460                 


Lys Lys Ile Gly Asn Phe Ser Leu Lys Ala Ile Arg Glu Phe Leu Pro 
465                 470                 475                 480 


Lys Met Phe Glu Gln Asn Lys Asn Ser Glu Tyr Leu Lys Trp Lys Asp 
                485                 490                 495     


Glu Glu Ile Arg Arg Lys Trp Glu Glu Gln Lys Ser Lys Leu Gly Lys 
            500                 505                 510         


Thr Asp Lys Lys Thr Lys Tyr Leu Asn Pro Arg Ile Phe Gln Asp Glu 
        515                 520                 525             


Ile Ile Ser Pro Gly Thr Lys Asn Thr Phe Glu Gln Ala Val Leu Val 
    530                 535                 540                 


Leu Asn Gln Ile Ile Lys Lys Tyr Ser Lys Glu Asn Ile Ile Asp Ala 
545                 550                 555                 560 


Ile Ile Ile Glu Ser Pro Arg Glu Lys Asn Asp Lys Lys Thr Ile Glu 
                565                 570                 575     


Glu Ile Lys Lys Arg Asn Lys Lys Gly Lys Gly Lys Thr Leu Glu Lys 
            580                 585                 590         


Leu Phe Gln Ile Leu Asn Leu Glu Asn Lys Gly Tyr Lys Leu Ser Asp 
        595                 600                 605             


Leu Glu Thr Lys Pro Ala Lys Leu Leu Asp Arg Leu Arg Phe Tyr His 
    610                 615                 620                 


Gln Gln Asp Gly Ile Asp Leu Tyr Thr Leu Asp Lys Ile Asn Ile Asp 
625                 630                 635                 640 


Gln Leu Ile Asn Gly Ser Gln Lys Tyr Glu Ile Glu His Ile Ile Pro 
                645                 650                 655     


Tyr Ser Met Ser Tyr Asp Asn Ser Gln Ala Asn Lys Ile Leu Thr Glu 
            660                 665                 670         


Lys Ala Glu Asn Leu Lys Lys Gly Lys Leu Ile Ala Ser Glu Tyr Ile 
        675                 680                 685             


Lys Arg Asn Gly Asp Glu Phe Tyr Asn Lys Tyr Tyr Glu Lys Ala Lys 
    690                 695                 700                 


Glu Leu Phe Ile Asn Lys Tyr Lys Lys Asn Lys Lys Leu Asp Ser Tyr 
705                 710                 715                 720 


Val Asp Leu Asp Glu Asp Ser Ala Lys Asn Arg Phe Arg Phe Leu Thr 
                725                 730                 735     


Leu Gln Asp Tyr Asp Glu Phe Gln Val Glu Phe Leu Ala Arg Asn Leu 
            740                 745                 750         


Asn Asp Thr Arg Tyr Ser Thr Lys Leu Phe Tyr His Ala Leu Val Glu 
        755                 760                 765             


His Phe Glu Asn Asn Glu Phe Phe Thr Tyr Ile Asp Glu Asn Ser Ser 
    770                 775                 780                 


Lys His Lys Val Lys Ile Ser Thr Ile Lys Gly His Val Thr Lys Tyr 
785                 790                 795                 800 


Phe Arg Ala Lys Pro Val Gln Lys Asn Asn Gly Pro Asn Glu Asn Leu 
                805                 810                 815     


Asn Asn Asn Lys Pro Glu Lys Ile Glu Lys Asn Arg Glu Asn Asn Glu 
            820                 825                 830         


His His Ala Val Asp Ala Ala Ile Val Ala Ile Ile Gly Asn Lys Asn 
        835                 840                 845             


Pro Gln Ile Ala Asn Leu Leu Thr Leu Ala Asp Asn Lys Thr Asp Lys 
    850                 855                 860                 


Lys Phe Leu Leu His Asp Glu Asn Tyr Lys Glu Asn Ile Glu Thr Gly 
865                 870                 875                 880 


Glu Leu Val Lys Ile Pro Lys Phe Glu Val Asp Lys Leu Ala Lys Val 
                885                 890                 895     


Glu Asp Leu Lys Lys Ile Ile Gln Glu Lys Tyr Glu Glu Ala Lys Lys 
            900                 905                 910         


His Thr Ala Ile Lys Phe Ser Arg Lys Thr Arg Thr Ile Leu Asn Gly 
        915                 920                 925             


Gly Leu Ser Asp Glu Thr Leu Tyr Gly Phe Lys Tyr Asp Glu Lys Glu 
    930                 935                 940                 


Asp Lys Tyr Phe Lys Ile Ile Lys Lys Lys Leu Val Thr Ser Lys Asn 
945                 950                 955                 960 


Glu Glu Leu Lys Lys Tyr Phe Glu Asn Pro Phe Gly Lys Lys Ala Asp 
                965                 970                 975     


Gly Lys Ser Glu Tyr Thr Val Leu Met Ala Gln Ser His Leu Ser Glu 
            980                 985                 990         


Phe Asn Lys Leu Lys Glu Ile Phe  Glu Lys Tyr Asn Gly  Phe Ser Asn 
        995                 1000                 1005             


Lys Thr  Gly Asn Ala Phe Val  Glu Tyr Met Asn Asp  Leu Ala Leu 
    1010                 1015                 1020             


Lys Glu  Pro Thr Leu Lys Ala  Glu Ile Glu Ser Ala  Lys Ser Val 
    1025                 1030                 1035             


Glu Lys  Leu Leu Tyr Tyr Asn  Phe Lys Pro Ser Asp  Gln Phe Thr 
    1040                 1045                 1050             


Tyr His  Asp Asn Ile Asn Asn  Lys Ser Phe Lys Arg  Phe Tyr Lys 
    1055                 1060                 1065             


Asn Ile  Arg Ile Ile Glu Tyr  Lys Ser Ile Pro Ile  Lys Phe Lys 
    1070                 1075                 1080             


Ile Leu  Ser Lys His Asp Gly  Gly Lys Ser Phe Lys  Asp Thr Leu 
    1085                 1090                 1095             


Phe Ser  Leu Tyr Ser Leu Val  Tyr Lys Val Tyr Glu  Asn Gly Lys 
    1100                 1105                 1110             


Glu Ser  Tyr Lys Ser Ile Pro  Val Thr Ser Gln Met  Arg Asn Phe 
    1115                 1120                 1125             


Gly Ile  Asp Glu Phe Asp Phe  Leu Asp Glu Asn Leu  Tyr Asn Lys 
    1130                 1135                 1140             


Glu Lys  Leu Asp Ile Tyr Lys  Ser Asp Phe Ala Lys  Pro Ile Pro 
    1145                 1150                 1155             


Val Asn  Cys Lys Pro Val Phe  Val Leu Lys Lys Gly  Ser Ile Leu 
    1160                 1165                 1170             


Lys Lys  Lys Ser Leu Asp Ile  Asp Asp Phe Lys Glu  Thr Lys Glu 
    1175                 1180                 1185             


Thr Glu  Glu Gly Asn Tyr Tyr  Phe Ile Ser Thr Ile  Ser Lys Arg 
    1190                 1195                 1200             


Phe Asn  Arg Asp Thr Ala Tyr  Gly Leu Lys Pro Leu  Lys Leu Ser 
    1205                 1210                 1215             


Val Val  Lys Pro Val Ala Glu  Pro Ser Thr Asn Pro  Ile Phe Lys 
    1220                 1225                 1230             


Glu Tyr  Ile Pro Ile His Leu  Asp Glu Leu Gly Asn  Glu Tyr Pro 
    1235                 1240                 1245             


Val Lys  Ile Lys Glu His Thr  Asp Asp Glu Lys Leu  Met Cys Thr 
    1250                 1255                 1260             


Ile Lys  
    1265 


<210> 337
<211> 1314
<212> PRT
<213> Mycoplasma synoviae

<400> 337
Met Leu Arg Leu Tyr Cys Ala Asn Asn Leu Val Leu Asn Asn Val Gln 
1               5                   10                  15      


Asn Leu Trp Lys Tyr Leu Leu Leu Leu Ile Phe Asp Lys Lys Ile Ile 
            20                  25                  30          


Phe Leu Phe Lys Ile Lys Val Ile Leu Ile Arg Arg Tyr Met Glu Asn 
        35                  40                  45              


Asn Asn Lys Glu Lys Ile Val Ile Gly Phe Asp Leu Gly Val Ala Ser 
    50                  55                  60                  


Val Gly Trp Ser Ile Val Asn Ala Glu Thr Lys Glu Val Ile Asp Leu 
65                  70                  75                  80  


Gly Val Arg Leu Phe Ser Glu Pro Glu Lys Ala Asp Tyr Arg Arg Ala 
                85                  90                  95      


Lys Arg Thr Thr Arg Arg Leu Leu Arg Arg Lys Lys Phe Lys Arg Glu 
            100                 105                 110         


Lys Phe His Lys Leu Ile Leu Lys Asn Ala Glu Ile Phe Gly Leu Gln 
        115                 120                 125             


Ser Arg Asn Glu Ile Leu Asn Val Tyr Lys Asp Gln Ser Ser Lys Tyr 
    130                 135                 140                 


Arg Asn Ile Leu Lys Leu Lys Ile Asn Ala Leu Lys Glu Glu Ile Lys 
145                 150                 155                 160 


Pro Ser Glu Leu Val Trp Ile Leu Arg Asp Tyr Leu Gln Asn Arg Gly 
                165                 170                 175     


Tyr Phe Tyr Lys Asn Glu Lys Leu Thr Asp Glu Phe Val Ser Asn Ser 
            180                 185                 190         


Phe Pro Ser Lys Lys Leu His Glu His Tyr Glu Lys Tyr Gly Phe Phe 
        195                 200                 205             


Arg Gly Ser Val Lys Leu Asp Asn Lys Leu Asp Asn Lys Lys Asp Lys 
    210                 215                 220                 


Ala Lys Glu Lys Asp Glu Glu Glu Glu Ser Asp Ala Lys Lys Glu Ser 
225                 230                 235                 240 


Glu Glu Leu Ile Phe Ser Asn Lys Gln Trp Ile Asn Glu Ile Val Lys 
                245                 250                 255     


Val Phe Glu Asn Gln Ser Tyr Leu Thr Glu Ser Phe Lys Glu Glu Tyr 
            260                 265                 270         


Leu Lys Leu Phe Asn Tyr Val Arg Pro Phe Asn Lys Gly Pro Gly Ser 
        275                 280                 285             


Lys Asn Ser Arg Thr Ala Tyr Gly Val Phe Ser Thr Asp Ile Asp Pro 
    290                 295                 300                 


Glu Thr Asn Lys Phe Lys Asp Tyr Ser Asn Ile Trp Asp Lys Thr Ile 
305                 310                 315                 320 


Gly Lys Cys Ser Leu Phe Glu Glu Glu Ile Arg Ala Pro Lys Asn Leu 
                325                 330                 335     


Pro Ser Ala Leu Ile Phe Asn Leu Gln Asn Glu Ile Cys Thr Ile Lys 
            340                 345                 350         


Asn Glu Phe Thr Glu Phe Lys Asn Trp Trp Leu Asn Ala Glu Gln Lys 
        355                 360                 365             


Ser Glu Ile Leu Lys Phe Val Phe Thr Glu Leu Phe Asn Trp Lys Asp 
    370                 375                 380                 


Lys Lys Tyr Ser Asp Lys Lys Phe Asn Lys Asn Leu Gln Asp Lys Ile 
385                 390                 395                 400 


Lys Lys Tyr Leu Leu Asn Phe Ala Leu Glu Asn Phe Asn Leu Asn Glu 
                405                 410                 415     


Glu Ile Leu Lys Asn Arg Asp Leu Glu Asn Asp Thr Val Leu Gly Leu 
            420                 425                 430         


Lys Gly Val Lys Tyr Tyr Glu Lys Ser Asn Ala Thr Ala Asp Ala Ala 
        435                 440                 445             


Leu Glu Phe Ser Ser Leu Lys Pro Leu Tyr Val Phe Ile Lys Phe Leu 
    450                 455                 460                 


Lys Glu Lys Lys Leu Asp Leu Asn Tyr Leu Leu Gly Leu Glu Asn Thr 
465                 470                 475                 480 


Glu Ile Leu Tyr Phe Leu Asp Ser Ile Tyr Leu Ala Ile Ser Tyr Ser 
                485                 490                 495     


Ser Asp Leu Lys Glu Arg Asn Glu Trp Phe Lys Lys Leu Leu Lys Glu 
            500                 505                 510         


Leu Tyr Pro Lys Ile Lys Asn Asn Asn Leu Glu Ile Ile Glu Asn Val 
        515                 520                 525             


Glu Asp Ile Phe Glu Ile Thr Asp Gln Glu Lys Phe Glu Ser Phe Ser 
    530                 535                 540                 


Lys Thr His Ser Leu Ser Arg Glu Ala Phe Asn His Ile Ile Pro Leu 
545                 550                 555                 560 


Leu Leu Ser Asn Asn Glu Gly Lys Asn Tyr Glu Ser Leu Lys His Ser 
                565                 570                 575     


Asn Glu Glu Leu Lys Lys Arg Thr Glu Lys Ala Glu Leu Lys Ala Gln 
            580                 585                 590         


Gln Asn Gln Lys Tyr Leu Lys Asp Asn Phe Leu Lys Glu Ala Leu Val 
        595                 600                 605             


Pro Leu Ser Val Lys Thr Ser Val Leu Gln Ala Ile Lys Ile Phe Asn 
    610                 615                 620                 


Gln Ile Ile Lys Asn Phe Gly Lys Lys Tyr Glu Ile Ser Gln Val Val 
625                 630                 635                 640 


Ile Glu Met Ala Arg Glu Leu Thr Lys Pro Asn Leu Glu Lys Leu Leu 
                645                 650                 655     


Asn Asn Ala Thr Asn Ser Asn Ile Lys Ile Leu Lys Glu Lys Leu Asp 
            660                 665                 670         


Gln Thr Glu Lys Phe Asp Asp Phe Thr Lys Lys Lys Phe Ile Asp Lys 
        675                 680                 685             


Ile Glu Asn Ser Val Val Phe Arg Asn Lys Leu Phe Leu Trp Phe Glu 
    690                 695                 700                 


Gln Asp Arg Lys Asp Pro Tyr Thr Gln Leu Asp Ile Lys Ile Asn Glu 
705                 710                 715                 720 


Ile Glu Asp Glu Thr Glu Ile Asp His Val Ile Pro Tyr Ser Lys Ser 
                725                 730                 735     


Ala Asp Asp Ser Trp Phe Asn Lys Leu Leu Val Lys Lys Ser Thr Asn 
            740                 745                 750         


Gln Leu Lys Lys Asn Lys Thr Val Trp Glu Tyr Tyr Gln Asn Glu Ser 
        755                 760                 765             


Asp Pro Glu Ala Lys Trp Asn Lys Phe Val Ala Trp Ala Lys Arg Ile 
    770                 775                 780                 


Tyr Leu Val Gln Lys Ser Asp Lys Glu Ser Lys Asp Asn Ser Glu Lys 
785                 790                 795                 800 


Asn Ser Ile Phe Lys Asn Lys Lys Pro Asn Leu Lys Phe Lys Asn Ile 
                805                 810                 815     


Thr Lys Lys Leu Phe Asp Pro Tyr Lys Asp Leu Gly Phe Leu Ala Arg 
            820                 825                 830         


Asn Leu Asn Asp Thr Arg Tyr Ala Thr Lys Val Phe Arg Asp Gln Leu 
        835                 840                 845             


Asn Asn Tyr Ser Lys His His Ser Lys Asp Asp Glu Asn Lys Leu Phe 
    850                 855                 860                 


Lys Val Val Cys Met Asn Gly Ser Ile Thr Ser Phe Leu Arg Lys Ser 
865                 870                 875                 880 


Met Trp Arg Lys Asn Glu Glu Gln Val Tyr Arg Phe Asn Phe Trp Lys 
                885                 890                 895     


Lys Asp Arg Asp Gln Phe Phe His His Ala Val Asp Ala Ser Ile Ile 
            900                 905                 910         


Ala Ile Phe Ser Leu Leu Thr Lys Thr Leu Tyr Asn Lys Leu Arg Val 
        915                 920                 925             


Tyr Glu Ser Tyr Asp Val Gln Arg Arg Glu Asp Gly Val Tyr Leu Ile 
    930                 935                 940                 


Asn Lys Glu Thr Gly Glu Val Lys Lys Ala Asp Lys Asp Tyr Trp Lys 
945                 950                 955                 960 


Asp Gln His Asn Phe Leu Lys Ile Arg Glu Asn Ala Ile Glu Ile Lys 
                965                 970                 975     


Asn Val Leu Asn Asn Val Asp Phe Gln Asn Gln Val Arg Tyr Ser Arg 
            980                 985                 990         


Lys Ala Asn Thr Lys Leu Asn Thr  Gln Leu Phe Asn Glu  Thr Leu Tyr 
        995                 1000                 1005             


Gly Val  Lys Glu Phe Glu Asn  Asn Phe Tyr Lys Leu  Glu Lys Val 
    1010                 1015                 1020             


Asn Leu  Phe Ser Arg Lys Asp  Leu Arg Lys Phe Ile  Leu Glu Asp 
    1025                 1030                 1035             


Leu Asn  Glu Glu Ser Glu Lys  Asn Lys Lys Asn Glu  Asn Gly Ser 
    1040                 1045                 1050             


Arg Lys  Arg Ile Leu Thr Glu  Lys Tyr Ile Val Asp  Glu Ile Leu 
    1055                 1060                 1065             


Gln Ile  Leu Glu Asn Glu Glu  Phe Lys Asp Ser Lys  Ser Asp Ile 
    1070                 1075                 1080             


Asn Ala  Leu Asn Lys Tyr Met  Asp Ser Leu Pro Ser  Lys Phe Ser 
    1085                 1090                 1095             


Glu Phe  Phe Ser Gln Asp Phe  Ile Asn Lys Cys Lys  Lys Glu Asn 
    1100                 1105                 1110             


Ser Leu  Ile Leu Thr Phe Asp  Ala Ile Lys His Asn  Asp Pro Lys 
    1115                 1120                 1125             


Lys Val  Ile Lys Ile Lys Asn  Leu Lys Phe Phe Arg  Glu Asp Ala 
    1130                 1135                 1140             


Thr Leu  Lys Asn Lys Gln Ala  Val His Lys Asp Ser  Lys Asn Gln 
    1145                 1150                 1155             


Ile Lys  Ser Phe Tyr Glu Ser  Tyr Lys Cys Val Gly  Phe Ile Trp 
    1160                 1165                 1170             


Leu Lys  Asn Lys Asn Asp Leu  Glu Glu Ser Ile Phe  Val Pro Ile 
    1175                 1180                 1185             


Asn Ser  Arg Val Ile His Phe  Gly Asp Lys Asp Lys  Asp Ile Phe 
    1190                 1195                 1200             


Asp Phe  Asp Ser Tyr Asn Lys  Glu Lys Leu Leu Asn  Glu Ile Asn 
    1205                 1210                 1215             


Leu Lys  Arg Pro Glu Asn Lys  Lys Phe Asn Ser Ile  Asn Glu Ile 
    1220                 1225                 1230             


Glu Phe  Val Lys Phe Val Lys  Pro Gly Ala Leu Leu  Leu Asn Phe 
    1235                 1240                 1245             


Glu Asn  Gln Gln Ile Tyr Tyr  Ile Ser Thr Leu Glu  Ser Ser Ser 
    1250                 1255                 1260             


Leu Arg  Ala Lys Ile Lys Leu  Leu Asn Lys Met Asp  Lys Gly Lys 
    1265                 1270                 1275             


Ala Val  Ser Met Lys Lys Ile  Thr Asn Pro Asp Glu  Tyr Lys Ile 
    1280                 1285                 1290             


Ile Glu  His Val Asn Pro Leu  Gly Ile Asn Leu Asn  Trp Thr Lys 
    1295                 1300                 1305             


Lys Leu  Glu Asn Asn Asn 
    1310                 


<210> 338
<211> 1304
<212> PRT
<213> Mycoplasma synoviae


<220>
<223> Mycoplasma synoviae 53

<400> 338
Met Leu Asn Asn Val Gln Asn Leu Trp Lys Tyr Leu Leu Leu Leu Ile 
1               5                   10                  15      


Phe Asp Lys Lys Ile Ile Phe Leu Phe Lys Ile Lys Val Ile Leu Ile 
            20                  25                  30          


Arg Arg Tyr Met Glu Asn Asn Asn Lys Glu Lys Ile Val Ile Gly Phe 
        35                  40                  45              


Asp Leu Gly Val Ala Ser Val Gly Trp Ser Ile Val Asn Ala Glu Thr 
    50                  55                  60                  


Lys Glu Val Ile Asp Leu Gly Val Arg Leu Phe Ser Glu Pro Glu Lys 
65                  70                  75                  80  


Ala Asp Tyr Arg Arg Ala Lys Arg Thr Thr Arg Arg Leu Leu Arg Arg 
                85                  90                  95      


Lys Lys Phe Lys Arg Glu Lys Phe His Lys Leu Ile Leu Lys Asn Ala 
            100                 105                 110         


Glu Ile Phe Gly Leu Gln Ser Arg Asn Glu Ile Leu Asn Val Tyr Lys 
        115                 120                 125             


Asp Gln Ser Ser Lys Tyr Arg Asn Ile Leu Lys Leu Lys Ile Asn Ala 
    130                 135                 140                 


Leu Lys Glu Glu Ile Lys Pro Ser Glu Leu Val Trp Ile Leu Arg Asp 
145                 150                 155                 160 


Tyr Leu Gln Asn Arg Gly Tyr Phe Tyr Lys Asn Glu Lys Leu Thr Asp 
                165                 170                 175     


Glu Phe Val Ser Asn Ser Phe Pro Ser Lys Lys Leu His Glu His Tyr 
            180                 185                 190         


Glu Lys Tyr Gly Phe Phe Arg Gly Ser Val Lys Leu Asp Asn Lys Leu 
        195                 200                 205             


Asp Asn Lys Lys Asp Lys Ala Lys Glu Lys Asp Glu Glu Glu Glu Ser 
    210                 215                 220                 


Asp Ala Lys Lys Glu Ser Glu Glu Leu Ile Phe Ser Asn Lys Gln Trp 
225                 230                 235                 240 


Ile Asn Glu Ile Val Lys Val Phe Glu Asn Gln Ser Tyr Leu Thr Glu 
                245                 250                 255     


Ser Phe Lys Glu Glu Tyr Leu Lys Leu Phe Asn Tyr Val Arg Pro Phe 
            260                 265                 270         


Asn Lys Gly Pro Gly Ser Lys Asn Ser Arg Thr Ala Tyr Gly Val Phe 
        275                 280                 285             


Ser Thr Asp Ile Asp Pro Glu Thr Asn Lys Phe Lys Asp Tyr Ser Asn 
    290                 295                 300                 


Ile Trp Asp Lys Thr Ile Gly Lys Cys Ser Leu Phe Glu Glu Glu Ile 
305                 310                 315                 320 


Arg Ala Pro Lys Asn Leu Pro Ser Ala Leu Ile Phe Asn Leu Gln Asn 
                325                 330                 335     


Glu Ile Cys Thr Ile Lys Asn Glu Phe Thr Glu Phe Lys Asn Trp Trp 
            340                 345                 350         


Leu Asn Ala Glu Gln Lys Ser Glu Ile Leu Lys Phe Val Phe Thr Glu 
        355                 360                 365             


Leu Phe Asn Trp Lys Asp Lys Lys Tyr Ser Asp Lys Lys Phe Asn Lys 
    370                 375                 380                 


Asn Leu Gln Asp Lys Ile Lys Lys Tyr Leu Leu Asn Phe Ala Leu Glu 
385                 390                 395                 400 


Asn Phe Asn Leu Asn Glu Glu Ile Leu Lys Asn Arg Asp Leu Glu Asn 
                405                 410                 415     


Asp Thr Val Leu Gly Leu Lys Gly Val Lys Tyr Tyr Glu Lys Ser Asn 
            420                 425                 430         


Ala Thr Ala Asp Ala Ala Leu Glu Phe Ser Ser Leu Lys Pro Leu Tyr 
        435                 440                 445             


Val Phe Ile Lys Phe Leu Lys Glu Lys Lys Leu Asp Leu Asn Tyr Leu 
    450                 455                 460                 


Leu Gly Leu Glu Asn Thr Glu Ile Leu Tyr Phe Leu Asp Ser Ile Tyr 
465                 470                 475                 480 


Leu Ala Ile Ser Tyr Ser Ser Asp Leu Lys Glu Arg Asn Glu Trp Phe 
                485                 490                 495     


Lys Lys Leu Leu Lys Glu Leu Tyr Pro Lys Ile Lys Asn Asn Asn Leu 
            500                 505                 510         


Glu Ile Ile Glu Asn Val Glu Asp Ile Phe Glu Ile Thr Asp Gln Glu 
        515                 520                 525             


Lys Phe Glu Ser Phe Ser Lys Thr His Ser Leu Ser Arg Glu Ala Phe 
    530                 535                 540                 


Asn His Ile Ile Pro Leu Leu Leu Ser Asn Asn Glu Gly Lys Asn Tyr 
545                 550                 555                 560 


Glu Ser Leu Lys His Ser Asn Glu Glu Leu Lys Lys Arg Thr Glu Lys 
                565                 570                 575     


Ala Glu Leu Lys Ala Gln Gln Asn Gln Lys Tyr Leu Lys Asp Asn Phe 
            580                 585                 590         


Leu Lys Glu Ala Leu Val Pro Leu Ser Val Lys Thr Ser Val Leu Gln 
        595                 600                 605             


Ala Ile Lys Ile Phe Asn Gln Ile Ile Lys Asn Phe Gly Lys Lys Tyr 
    610                 615                 620                 


Glu Ile Ser Gln Val Val Ile Glu Met Ala Arg Glu Leu Thr Lys Pro 
625                 630                 635                 640 


Asn Leu Glu Lys Leu Leu Asn Asn Ala Thr Asn Ser Asn Ile Lys Ile 
                645                 650                 655     


Leu Lys Glu Lys Leu Asp Gln Thr Glu Lys Phe Asp Asp Phe Thr Lys 
            660                 665                 670         


Lys Lys Phe Ile Asp Lys Ile Glu Asn Ser Val Val Phe Arg Asn Lys 
        675                 680                 685             


Leu Phe Leu Trp Phe Glu Gln Asp Arg Lys Asp Pro Tyr Thr Gln Leu 
    690                 695                 700                 


Asp Ile Lys Ile Asn Glu Ile Glu Asp Glu Thr Glu Ile Asp His Val 
705                 710                 715                 720 


Ile Pro Tyr Ser Lys Ser Ala Asp Asp Ser Trp Phe Asn Lys Leu Leu 
                725                 730                 735     


Val Lys Lys Ser Thr Asn Gln Leu Lys Lys Asn Lys Thr Val Trp Glu 
            740                 745                 750         


Tyr Tyr Gln Asn Glu Ser Asp Pro Glu Ala Lys Trp Asn Lys Phe Val 
        755                 760                 765             


Ala Trp Ala Lys Arg Ile Tyr Leu Val Gln Lys Ser Asp Lys Glu Ser 
    770                 775                 780                 


Lys Asp Asn Ser Glu Lys Asn Ser Ile Phe Lys Asn Lys Lys Pro Asn 
785                 790                 795                 800 


Leu Lys Phe Lys Asn Ile Thr Lys Lys Leu Phe Asp Pro Tyr Lys Asp 
                805                 810                 815     


Leu Gly Phe Leu Ala Arg Asn Leu Asn Asp Thr Arg Tyr Ala Thr Lys 
            820                 825                 830         


Val Phe Arg Asp Gln Leu Asn Asn Tyr Ser Lys His His Ser Lys Asp 
        835                 840                 845             


Asp Glu Asn Lys Leu Phe Lys Val Val Cys Met Asn Gly Ser Ile Thr 
    850                 855                 860                 


Ser Phe Leu Arg Lys Ser Met Trp Arg Lys Asn Glu Glu Gln Val Tyr 
865                 870                 875                 880 


Arg Phe Asn Phe Trp Lys Lys Asp Arg Asp Gln Phe Phe His His Ala 
                885                 890                 895     


Val Asp Ala Ser Ile Ile Ala Ile Phe Ser Leu Leu Thr Lys Thr Leu 
            900                 905                 910         


Tyr Asn Lys Leu Arg Val Tyr Glu Ser Tyr Asp Val Gln Arg Arg Glu 
        915                 920                 925             


Asp Gly Val Tyr Leu Ile Asn Lys Glu Thr Gly Glu Val Lys Lys Ala 
    930                 935                 940                 


Asp Lys Asp Tyr Trp Lys Asp Gln His Asn Phe Leu Lys Ile Arg Glu 
945                 950                 955                 960 


Asn Ala Ile Glu Ile Lys Asn Val Leu Asn Asn Val Asp Phe Gln Asn 
                965                 970                 975     


Gln Val Arg Tyr Ser Arg Lys Ala Asn Thr Lys Leu Asn Thr Gln Leu 
            980                 985                 990         


Phe Asn Glu Thr Leu Tyr Gly Val  Lys Glu Phe Glu Asn  Asn Phe Tyr 
        995                 1000                 1005             


Lys Leu  Glu Lys Val Asn Leu  Phe Ser Arg Lys Asp  Leu Arg Lys 
    1010                 1015                 1020             


Phe Ile  Leu Glu Asp Leu Asn  Glu Glu Ser Glu Lys  Asn Lys Lys 
    1025                 1030                 1035             


Asn Glu  Asn Gly Ser Arg Lys  Arg Ile Leu Thr Glu  Lys Tyr Ile 
    1040                 1045                 1050             


Val Asp  Glu Ile Leu Gln Ile  Leu Glu Asn Glu Glu  Phe Lys Asp 
    1055                 1060                 1065             


Ser Lys  Ser Asp Ile Asn Ala  Leu Asn Lys Tyr Met  Asp Ser Leu 
    1070                 1075                 1080             


Pro Ser  Lys Phe Ser Glu Phe  Phe Ser Gln Asp Phe  Ile Asn Lys 
    1085                 1090                 1095             


Cys Lys  Lys Glu Asn Ser Leu  Ile Leu Thr Phe Asp  Ala Ile Lys 
    1100                 1105                 1110             


His Asn  Asp Pro Lys Lys Val  Ile Lys Ile Lys Asn  Leu Lys Phe 
    1115                 1120                 1125             


Phe Arg  Glu Asp Ala Thr Leu  Lys Asn Lys Gln Ala  Val His Lys 
    1130                 1135                 1140             


Asp Ser  Lys Asn Gln Ile Lys  Ser Phe Tyr Glu Ser  Tyr Lys Cys 
    1145                 1150                 1155             


Val Gly  Phe Ile Trp Leu Lys  Asn Lys Asn Asp Leu  Glu Glu Ser 
    1160                 1165                 1170             


Ile Phe  Val Pro Ile Asn Ser  Arg Val Ile His Phe  Gly Asp Lys 
    1175                 1180                 1185             


Asp Lys  Asp Ile Phe Asp Phe  Asp Ser Tyr Asn Lys  Glu Lys Leu 
    1190                 1195                 1200             


Leu Asn  Glu Ile Asn Leu Lys  Arg Pro Glu Asn Lys  Lys Phe Asn 
    1205                 1210                 1215             


Ser Ile  Asn Glu Ile Glu Phe  Val Lys Phe Val Lys  Pro Gly Ala 
    1220                 1225                 1230             


Leu Leu  Leu Asn Phe Glu Asn  Gln Gln Ile Tyr Tyr  Ile Ser Thr 
    1235                 1240                 1245             


Leu Glu  Ser Ser Ser Leu Arg  Ala Lys Ile Lys Leu  Leu Asn Lys 
    1250                 1255                 1260             


Met Asp  Lys Gly Lys Ala Val  Ser Met Lys Lys Ile  Thr Asn Pro 
    1265                 1270                 1275             


Asp Glu  Tyr Lys Ile Ile Glu  His Val Asn Pro Leu  Gly Ile Asn 
    1280                 1285                 1290             


Leu Asn  Trp Thr Lys Lys Leu  Glu Asn Asn Asn 
    1295                 1300                 


<210> 339
<211> 1401
<212> PRT
<213> Myroides injenensis


<220>
<223> Myroides injenensis M09-0166

<400> 339
Met Lys Arg Ile Leu Gly Leu Asp Leu Gly Thr Thr Ser Ile Gly Trp 
1               5                   10                  15      


Ala Tyr Val His Glu Ala Glu Asn Val Asn Glu Thr Ser Ser Ile Gln 
            20                  25                  30          


Lys Val Gly Val Arg Val Asn Pro Leu Thr Thr Glu Glu Gln Thr Asn 
        35                  40                  45              


Phe Glu Lys Gly Lys Pro Ile Thr Thr Asn Ala Ser Arg Thr Leu Ala 
    50                  55                  60                  


Arg Ser Ala Arg Arg Asn Leu Gln Arg Tyr Lys Leu Arg Arg Asp Asn 
65                  70                  75                  80  


Leu Ile Gln Ile Leu Lys Glu Asn Asn Trp Ile Asn Asn Thr Thr Ser 
                85                  90                  95      


Leu Thr Glu Thr Gly Asn His Ser Thr Phe Glu Thr Tyr Glu Leu Arg 
            100                 105                 110         


Asn Lys Ala Ala Ser Glu Lys Leu Thr Leu Asp Gln Leu Ser Arg Val 
        115                 120                 125             


Leu Leu Met Leu Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Val 
    130                 135                 140                 


Asn Ser Lys Glu Glu Gly Gln Leu Ile Asp Gly Met Glu Val Ala Lys 
145                 150                 155                 160 


Lys Leu Tyr His Glu Gln Leu Thr Pro Gly Gln Leu Ser Leu Gln Leu 
                165                 170                 175     


Met Asn Gln Gly Val Lys Lys Leu Pro Asp Tyr Tyr Arg Ser Asp Leu 
            180                 185                 190         


Asn Gln Glu Leu Glu Ser Ile Trp Asn Phe Gln Gln Gln Phe Tyr Pro 
        195                 200                 205             


Asn Ile Leu Thr Asp Lys Phe Lys Glu Glu Ile Asn Gly Lys Gly Leu 
    210                 215                 220                 


Thr Ser Thr Ser Ser Ala Phe Trp Asn Ile Tyr Asn Phe Asn Thr Ala 
225                 230                 235                 240 


Glu Asn Lys Gly Ser Arg Asp Glu Lys Lys Lys Gln Ala Leu Gln Trp 
                245                 250                 255     


Arg Ser Glu Ala Leu Ser Lys Gln Leu Ser Lys Glu Ile Val Ala Tyr 
            260                 265                 270         


Ile Ile Ala Asp Leu Asn Gly Gln Ile Tyr Asn Ser Ser Gly Tyr Leu 
        275                 280                 285             


Gly Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Asn Leu Thr 
    290                 295                 300                 


Val Gly Gln Tyr Leu Phe Lys Gln Leu Lys Ser Asn Pro His Thr Ser 
305                 310                 315                 320 


Leu Lys Asn Gln Val Phe Tyr Arg Gln Asp Tyr Leu Asn Glu Phe Glu 
                325                 330                 335     


Lys Ile Trp Glu Thr Gln Ser Lys Phe Tyr Pro Lys Glu Leu Thr Ala 
            340                 345                 350         


Ala Leu Lys Arg Glu Ile Arg Asp Val Ile Ile Phe Tyr Gln Arg Lys 
        355                 360                 365             


Leu Lys Ser Gln Lys Gly Leu Ile Ser Phe Cys Glu Phe Glu Gln Lys 
    370                 375                 380                 


Gln Lys Thr Ile Asn Gly Lys Thr Lys Thr Ile Gly His Arg Val Ile 
385                 390                 395                 400 


Pro Lys Ser Ser Pro Leu Phe Gln Glu Phe Lys Ile Trp Gln Gln Leu 
                405                 410                 415     


His Asn Val Val Leu Arg Asn Lys Lys Thr Asn Glu Ile Val Ser Leu 
            420                 425                 430         


Ala Asp Glu Gln Lys Val His Leu Phe Glu Glu Leu Asn Leu Lys Gly 
        435                 440                 445             


Lys Leu Lys Ser Asn Gln Val Leu Lys Leu Ile Glu Asn Lys Pro Lys 
    450                 455                 460                 


Asp Trp Glu Leu Asn Tyr Thr Glu Leu Glu Gly Asn Asn Thr Asn Lys 
465                 470                 475                 480 


Ala Leu Tyr Asn Ala Tyr Leu Asp Ile Leu Asp Ile Glu Gly Tyr Asp 
                485                 490                 495     


Val Arg Asn Glu Leu Lys Val Lys Leu Asn Lys Asp Asp Ile Glu Leu 
            500                 505                 510         


Ser Asp Leu Asp Val Asn Ala Ser Glu Ile Lys Glu Met Ile Phe Ser 
        515                 520                 525             


Val Phe Lys His Leu Gly Ile Asn Thr Glu Ile Leu Glu Phe Asp Ala 
    530                 535                 540                 


Thr Leu Glu Asp Lys Val Phe Glu Lys Gln Ala Ser Tyr Gln Leu Trp 
545                 550                 555                 560 


His Leu Leu Tyr Ser Tyr Glu Glu Asp Asn Ser Pro Thr Gly Leu Asp 
                565                 570                 575     


Arg Leu Tyr Asn Leu Leu His Lys Lys Phe Gly Phe Lys Leu Asn His 
            580                 585                 590         


Ala Lys Leu Ile Gly Asn Val Leu Phe Gln Asp Asp Tyr Gly Ser Leu 
        595                 600                 605             


Ser Ser Lys Ala Ile Lys Asn Ile Phe Pro Tyr Ile Thr Glu Asn Asn 
    610                 615                 620                 


Tyr Tyr Thr Ala Cys Glu Leu Ala Gly Tyr Lys His Ser Lys His Ser 
625                 630                 635                 640 


Leu Thr Lys Glu Glu Asn Glu Thr Arg Glu Leu Lys Asn Arg Leu Thr 
                645                 650                 655     


Ile Leu Pro Lys Asn Ser Leu Arg Asn Pro Val Val Glu Lys Ile Ile 
            660                 665                 670         


Asn Gln Met Ile Asn Val Val Asn Thr Leu Ile Asp Glu Glu Asn Asn 
        675                 680                 685             


Ile Leu Ile Ala Gln Gly Lys Glu Pro Asn Phe Gln Phe Asp Glu Ile 
    690                 695                 700                 


Arg Ile Glu Leu Ala Arg Glu Leu Lys Lys Asn Ala Lys Glu Arg Glu 
705                 710                 715                 720 


Glu Leu Thr Lys Ser Ile Asn Lys Ser Lys Thr Asp His Glu Lys Ile 
                725                 730                 735     


Ile Lys Ile Leu Gln Lys Glu Asp Gly Ile Lys Asn Pro Thr Arg Asn 
            740                 745                 750         


Asp Ile Val Arg Phe Lys Leu Tyr Ser Glu Leu Lys Asn Asn Gly Tyr 
        755                 760                 765             


Lys Asp Leu Tyr Thr Asn Glu Tyr Ile Glu Arg Lys Asp Ile Phe Thr 
    770                 775                 780                 


Lys Glu Tyr Asp Ile Glu His Ile Ile Pro Gln Ser Lys Leu Phe Asp 
785                 790                 795                 800 


Asp Ser Phe Ser Asn Lys Thr Leu Val Arg Arg Asn Val Asn Leu Lys 
                805                 810                 815     


Lys Gly Asn Gln Thr Ala Tyr Asp Phe Ile Leu Cys Glu Tyr Gly Gln 
            820                 825                 830         


Glu Lys Ala Asn Glu Phe Glu Thr Arg Ile Thr Asn Leu Tyr Asn Leu 
        835                 840                 845             


Gly Lys Asp Glu Gly Ile Ser Lys Ser Lys Phe Lys Lys Leu Leu Met 
    850                 855                 860                 


Gln Glu Ser Glu Ile Gly Asn Gly Phe Ile Glu Arg Asp Leu Arg Glu 
865                 870                 875                 880 


Thr Gln Tyr Ile Ala Lys Lys Ala Lys Ser Leu Leu Leu Glu Ile Thr 
                885                 890                 895     


Arg Asn Val Ile Ser Thr Ser Gly Ser Ile Thr Asp Arg Leu Arg Glu 
            900                 905                 910         


Asp Trp Gly Leu Ile Asn Val Met Lys Glu Leu Asn Leu Gln Lys Tyr 
        915                 920                 925             


Arg Asp Ala Gly Leu Thr Glu Phe Val Lys Met Lys Asp Gly Asn Lys 
    930                 935                 940                 


Lys Glu Val Ile Ile Asp Trp Thr Lys Arg Asn Asp His Arg His His 
945                 950                 955                 960 


Ala Met Asp Ala Leu Thr Ile Ala Phe Thr Lys His Asn His Ile Gln 
                965                 970                 975     


Tyr Leu Asn His Leu Asn Ala Arg Lys Asn Val Asn Asn Glu Leu His 
            980                 985                 990         


Asn Asn Ile Ile Ala Ile Glu Lys  Leu Glu Thr Thr Leu  Val Ser Asp 
        995                 1000                 1005             


Glu Arg  Gly Asn Lys Lys Arg  Ile Phe Lys Glu Pro  Ile Ala Asn 
    1010                 1015                 1020             


Phe Arg  Thr Ile Ala Lys Ser  His Leu Glu Ala Ile  Leu Val Ser 
    1025                 1030                 1035             


His Lys  Ala Lys Asn Lys Val  Val Thr Lys Asn Ile  Asn Lys Ile 
    1040                 1045                 1050             


Ser Gly  Lys Lys Ile Ser Gln  Gln Thr Leu Thr Pro  Arg Gly Gln 
    1055                 1060                 1065             


Leu His  Lys Glu Thr Ile Tyr  Gly Lys Ile Arg Gln  Tyr Val Ser 
    1070                 1075                 1080             


Lys Gln  Glu Lys Val Gly Pro  Lys Phe Thr Ile Glu  Val Ile Glu 
    1085                 1090                 1095             


Gln Val  Ser Asn Pro Thr Tyr  Arg Asn Leu Leu Leu  Lys Arg Leu 
    1100                 1105                 1110             


Glu Glu  Asn Asn Asn Asp Pro  Lys Lys Ala Phe Gly  Gly Lys Asn 
    1115                 1120                 1125             


Ser Leu  Asn Lys Asn Pro Ile  Tyr Ile Asn Leu Glu  Lys Asn Ile 
    1130                 1135                 1140             


Lys Val  Pro Glu Val Leu Lys  Leu Val Trp Leu Glu  Asp Asn Tyr 
    1145                 1150                 1155             


Thr Ile  Arg Lys Glu Ile Ser  Pro Asp Leu Lys Ile  Asp Lys Val 
    1160                 1165                 1170             


Ile Asp  Gln Gly Val Lys Gln  Ile Leu Gln Asn Arg  Leu Ala Gln 
    1175                 1180                 1185             


Tyr Lys  Gly Asp Ser Lys Leu  Ala Phe Ser Asn Leu  Asp Ala Asn 
    1190                 1195                 1200             


Pro Ile  Trp Leu Asn Glu Asp  Lys Gly Ile Ala Ile  Lys Arg Val 
    1205                 1210                 1215             


Thr Ile  Ser Gly Ile Ala Thr  Ala Gln Pro Leu His  Arg Lys Lys 
    1220                 1225                 1230             


Asp His  Leu Gly Gln Pro Ile  Leu Asp His Asn Gly  Gln Glu Ile 
    1235                 1240                 1245             


Pro Val  Asp Phe Ile Ser Thr  Gly Asn Asn His His  Val Ala Ile 
    1250                 1255                 1260             


Tyr Glu  Asp Glu Asn Gly Lys  Leu Gln Glu Ser Val  Val Ser His 
    1265                 1270                 1275             


Phe Glu  Ala Val Glu Arg Val  Asn Gln Lys Leu Pro  Ile Ile Asp 
    1280                 1285                 1290             


Lys Thr  Phe Asn Gln His Leu  Gly Trp Lys Phe Leu  Phe Thr Met 
    1295                 1300                 1305             


Lys Gln  Asn Glu Leu Phe Leu  Phe Pro Ser Asp Asp  Phe Asn Pro 
    1310                 1315                 1320             


Asn Glu  Ile Asp Leu Phe Asp  Lys Gln Asn Tyr Thr  Val Ile Ser 
    1325                 1330                 1335             


Lys His  Leu Phe Arg Ile Gln  Lys Leu Ser Thr Lys  Asp Tyr Ser 
    1340                 1345                 1350             


Phe Arg  His His Leu Glu Thr  Asn Val Glu Glu Ile  Lys Asp Leu 
    1355                 1360                 1365             


Lys Thr  Ile Thr Trp Arg Arg  Glu Gly Leu Asn Gly  Ile Gln Asn 
    1370                 1375                 1380             


Ile Ile  Lys Val Arg Thr Asn  His Leu Gly Glu Ile  Ile His Ile 
    1385                 1390                 1395             


Gly Glu  Tyr 
    1400     


<210> 340
<211> 1466
<212> PRT
<213> Myroides odoratus


<220>
<223> Myroides odoratus DSM 2801

<400> 340
Met Lys Asn Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Lys Glu Asp Phe Glu Asn Lys Gln Gly Glu Ile Leu Gly 
            20                  25                  30          


Leu Gly Ser Arg Ile Ile Pro Met Ser Gln Asp Ile Leu Gly Glu Phe 
        35                  40                  45              


Gly Arg Gly Asn Ser Ile Ser Gln Thr Ala Asp Arg Thr Gly Tyr Arg 
    50                  55                  60                  


Gly Val Arg Arg Leu Arg Glu Arg His Leu Leu Arg Arg Glu Arg Leu 
65                  70                  75                  80  


His Arg Val Leu Asn Ile Leu Gly Phe Leu Pro Asn His Tyr Ala Lys 
                85                  90                  95      


Glu Ile Asp Phe Thr Lys Arg Leu Gly Lys Phe Ile Asn His Ala Glu 
            100                 105                 110         


Pro Lys Leu Ser Phe Asp Lys Glu Phe Ile Phe Lys Asp Ser Phe Asn 
        115                 120                 125             


Glu Met Leu Lys Asp Phe Gln Gln Asn Gln Pro Gly Phe Ile Ile Asn 
    130                 135                 140                 


Lys His Gly Glu Glu Ala Leu Val Pro Tyr Asp Trp Thr Ile Tyr Tyr 
145                 150                 155                 160 


Leu Arg Lys Lys Ala Leu Thr Gln Lys Ile Asp Lys Glu Glu Leu Ala 
                165                 170                 175     


Trp Ile Leu Leu Asn Phe Asn Gln Lys Arg Gly Tyr Tyr Gln Leu Arg 
            180                 185                 190         


Gly Glu Glu Glu Glu Glu Asn Thr Asn Lys Leu Val Glu Phe Tyr Ser 
        195                 200                 205             


Leu Lys Ile Ile Asp Val Ile Ala Asp Asn Glu Val Asn Lys Lys Gly 
    210                 215                 220                 


Glu Val Trp Tyr Ser Leu His Leu Glu Asn Gly Trp Ile Tyr Arg Arg 
225                 230                 235                 240 


Ser Ser Lys Ile Ser Leu Val Asp Trp Lys Asp Lys Val Arg Asp Phe 
                245                 250                 255     


Ile Val Thr Thr Asp Val Asn Asp Asp Gly Ser Glu Lys Leu Asp Lys 
            260                 265                 270         


Asp Gly Val Val Lys Arg Ser Phe Arg Ala Pro Ser Ala Asp Asp Trp 
        275                 280                 285             


Thr Leu Leu Lys Lys Lys Thr Glu Gln Asp Ile Asp Asn Ser Asn Lys 
    290                 295                 300                 


Thr Val Gly Ala Tyr Ile Tyr Glu Asn Leu Leu Leu Asn Pro Lys Gln 
305                 310                 315                 320 


Lys Ile Lys Gly Lys Leu Val Arg Thr Ile Glu Arg Lys Phe Tyr Lys 
                325                 330                 335     


Asp Glu Leu Lys Gln Ile Leu Glu Lys Gln Lys Glu Phe His Gln Glu 
            340                 345                 350         


Leu Gln Asn Glu Gln Leu Leu Gln Asp Cys Val Arg Glu Leu Tyr Lys 
        355                 360                 365             


Tyr Asn Glu Gln His Gln Gln Met Leu Glu Ser Lys Asp Phe Val His 
    370                 375                 380                 


Leu Phe Leu Asn Asp Ile Ile Phe Tyr Gln Arg Pro Leu Arg Ser Gln 
385                 390                 395                 400 


Lys Ser Leu Ile Ser Asn Cys Thr Leu Glu Lys Arg Val Ser Arg Asp 
                405                 410                 415     


Gly Val Val Phe Pro Ile Lys Val Ile Ser Lys Ser Asn Pro Tyr Tyr 
            420                 425                 430         


Gln Glu Phe Arg Leu Leu Gln Trp Leu Gln Asn Leu Ala Ile Tyr Arg 
        435                 440                 445             


Lys Asp Asp Asp Val Asn Val Thr Gln Glu Phe Leu Asn Ser Ile Glu 
    450                 455                 460                 


Ser Trp Glu Asn Leu Leu Gln Phe Leu Asn Ala Lys Lys Glu Ile Lys 
465                 470                 475                 480 


Gln Glu Gln Leu Ile Lys Phe Leu Leu Glu Gln Lys Gly Leu Lys Gly 
                485                 490                 495     


Asn Ser Leu Lys Thr Ala Ile Leu Thr Tyr Arg Trp Asn Tyr Val Thr 
            500                 505                 510         


Asp Lys Val Tyr Pro Met Asn Glu Thr Arg Ser Leu Ile Gln Asp Lys 
        515                 520                 525             


Leu Lys Lys Val Glu Asn Val Ala Thr Asp Phe Leu Ser Phe Asp Asn 
    530                 535                 540                 


Glu Met Ala Leu Trp His Ile Ile Tyr Ser Val Asn Asp Lys Ile Glu 
545                 550                 555                 560 


Tyr Glu Lys Ala Leu Ala Lys Phe Ala Ser Lys His Asn Leu Asp Glu 
                565                 570                 575     


Ile Ser Phe Val Glu Ser Phe Lys Lys Phe Pro Pro Phe Lys Ser Asp 
            580                 585                 590         


Tyr Gly Ser Phe Ser Glu Lys Ala Ile Lys Lys Leu Leu Pro Leu Met 
        595                 600                 605             


Arg Phe Gly Ser Val Trp Asn Lys Asn Asn Ile Val Pro Ser Val Leu 
    610                 615                 620                 


Asp Arg Ile Asp Lys Ile Leu Thr Gly Glu Tyr Asp Glu Lys Ile Lys 
625                 630                 635                 640 


Ile Arg Val Arg Glu Lys Ala Glu Gln Phe Gln Leu Asn Gln Ile Glu 
                645                 650                 655     


Asp Phe Gln Asn Leu Pro Leu Trp Leu Ala Gln Tyr Val Val Tyr Asp 
            660                 665                 670         


Arg His Ser Glu Ala Glu Ile Ala Gly Lys Trp Asn Ser Val Lys Asp 
        675                 680                 685             


Leu Glu Asn Tyr Leu Lys Glu Phe Lys Gln His Ser Leu Arg Asn Pro 
    690                 695                 700                 


Ile Val Glu Gln Ile Ile Thr Glu Thr Leu Arg Val Val Lys Asp Ile 
705                 710                 715                 720 


Trp Gln Gln Tyr Gly Asn Gly Val Gln Asn Phe Phe Asp Glu Ile His 
                725                 730                 735     


Ile Glu Leu Gly Arg Glu Met Lys Asn Thr Ala Asp Glu Arg Lys Arg 
            740                 745                 750         


Ile Thr Asn Ser Val Thr Glu Asn Glu Asn Thr Asn Leu Arg Ile Lys 
        755                 760                 765             


Ala Leu Leu Val Glu Leu Lys Glu Asp Thr Asn Ile Glu Asn Val Arg 
    770                 775                 780                 


Pro His Ser Pro Met Gln Gln Glu Ile Leu Lys Ile Tyr Glu Glu Gly 
785                 790                 795                 800 


Val Leu Asn Ala Val Glu Asn Ile Asp Glu Asp Ile Leu Lys Ile Ser 
                805                 810                 815     


Lys Thr Ala Gln Pro Ser Lys Ser Glu Leu Ile Arg Tyr Lys Leu Trp 
            820                 825                 830         


Leu Glu Gln Lys Tyr Gln Ser Pro Tyr Thr Gly Glu Met Ile Pro Leu 
        835                 840                 845             


Ser Arg Leu Phe Thr Ser Asp Tyr Glu Ile Glu His Val Ile Pro Gln 
    850                 855                 860                 


Ser Arg Tyr Phe Asp Asp Ser Leu Ser Asn Lys Val Ile Cys Glu Ala 
865                 870                 875                 880 


Ala Val Asn Lys Arg Lys Asp Asn Gln Leu Gly Leu Glu Phe Ile Lys 
                885                 890                 895     


Asn His His Ser Glu Lys Ile Glu Leu Gly Asn Gly Arg Thr Ala Gln 
            900                 905                 910         


Val Leu Glu Val Glu Ala Tyr Glu Ser Phe Val Lys Lys Asn Tyr Asp 
        915                 920                 925             


Lys Asn Arg Gly Lys Arg Asn Lys Leu Leu Leu Glu Asp Val Pro Glu 
    930                 935                 940                 


Lys Met Ile Glu Arg Gln Leu Asn Asp Thr Arg Tyr Ile Ser Lys Phe 
945                 950                 955                 960 


Val Thr His Leu Leu Ser Asn Ile Val Arg Lys Asp Glu Val Asn Ser 
                965                 970                 975     


Lys Asp Asp Gly Ile Asn Ser Lys Asn Ile Ile Pro Gly Asn Gly Lys 
            980                 985                 990         


Ile Thr Ser Gln Leu Lys Gln Asp  Trp Gly Leu Asn Asp  Val Trp Asn 
        995                 1000                 1005             


Glu Leu  Ile Leu Pro Arg Phe  Glu Arg Met Asn Asn  Leu Thr Asn 
    1010                 1015                 1020             


Ser Thr  Asp Phe Thr Ser Thr  Asn Thr Asn Gly Lys  Ile Ile Pro 
    1025                 1030                 1035             


Thr Val  Pro Leu Glu Tyr Ser  Lys Gly Phe Ser Lys  Lys Arg Ile 
    1040                 1045                 1050             


Asp His  Arg His His Ala Leu  Asp Ala Leu Val Ile  Ala Leu Ala 
    1055                 1060                 1065             


Thr Arg  Asp His Val Asn Leu  Leu Asn Asn Glu Ser  Ala Leu Pro 
    1070                 1075                 1080             


Lys Lys  Asp Arg Thr Lys Glu  Glu Gln Lys Ser Phe  Arg Phe Asp 
    1085                 1090                 1095             


Leu Gln  Val Asn Leu Arg Asn  Lys Glu Lys Tyr Phe  Asn Val Lys 
    1100                 1105                 1110             


Glu Gly  Arg Glu Lys Glu Lys  Phe Thr Thr Phe Lys  Lys Pro Trp 
    1115                 1120                 1125             


Asn Thr  Leu Thr Gln Asp Thr  Arg Asp Ala Leu Glu  Asn Met Val 
    1130                 1135                 1140             


Val Ser  Phe Lys Gln Asn Leu  Arg Val Ile Asn Lys  Ala Thr Asn 
    1145                 1150                 1155             


Tyr Tyr  Glu Ser Tyr Thr Asp  Glu Asn Gly Asn Leu  Arg Leu Asp 
    1160                 1165                 1170             


Lys Tyr  Gly Asn Pro Lys Lys  Glu Leu Ile Ser Gln  Lys Gly Thr 
    1175                 1180                 1185             


Asn Trp  Ala Ile Arg Lys Ser  Leu His Lys Glu Thr  Val Ser Gly 
    1190                 1195                 1200             


Gln Ile  His Leu Asp Arg Val  Lys Val Thr Lys Gly  Lys Ile Val 
    1205                 1210                 1215             


Thr Ala  Thr Arg Lys Ser Leu  Asp Ser Ser Phe Asn  Glu Lys Ser 
    1220                 1225                 1230             


Ile Glu  Ser Ile Thr Asp Thr  Gly Ile Gln Lys Ile  Leu Arg Asn 
    1235                 1240                 1245             


Tyr Leu  Lys Ala Lys Asp Asn  Lys Pro Asp Val Ala  Phe Ser Pro 
    1250                 1255                 1260             


Glu Gly  Ile Glu Glu Leu Asn  Lys Ser Ile Ser Val  Tyr Asn Glu 
    1265                 1270                 1275             


Gly Lys  Asn His Gln Pro Ile  Ile Lys Val Arg Ile  Phe Glu Gln 
    1280                 1285                 1290             


Gly Ser  Lys Phe Pro Val Gly  Glu Thr Gly Asn Lys  Ile Ala Lys 
    1295                 1300                 1305             


Phe Val  Glu Ala Ala Lys Gly  Thr Asn Leu Phe Phe  Gly Ile Tyr 
    1310                 1315                 1320             


Gln Asp  Lys Thr Gly Lys Arg  Ser Tyr Asp Thr Ile  Pro Leu Asn 
    1325                 1330                 1335             


Leu Val  Ile Glu Arg Leu Lys  Gln Gly Leu Ser Pro  Val Pro Glu 
    1340                 1345                 1350             


Thr Asn  Glu Lys Gly His Gln  Leu Leu Phe His Leu  Ser Pro Asn 
    1355                 1360                 1365             


Asp Leu  Val Tyr Val Pro Thr  Ile Asp Asp Asn Glu  Gln Leu Asp 
    1370                 1375                 1380             


Ser Asn  Arg Val Tyr Lys Phe  Thr Asp Ser Ser Asp  Thr Thr Cys 
    1385                 1390                 1395             


Asn Phe  Ile Pro Ser Asn Ile  Ser Ala Ile Ile Phe  Asn Ile Asn 
    1400                 1405                 1410             


Ser Lys  Glu Gln Glu Lys Arg  Gly Ile Asn Tyr Pro  Ile Gln Asn 
    1415                 1420                 1425             


Glu Leu  Gly Val Gly Ser Pro  Gln Ser Lys Asn Gln  Lys Ser Phe 
    1430                 1435                 1440             


Asp Gly  Phe Met Ile Lys Glu  Val Cys Ile Lys Leu  Lys Val Asp 
    1445                 1450                 1455             


Arg Leu  Gly Asn Ile Ser Lys  Thr 
    1460                 1465     


<210> 341
<211> 1077
<212> PRT
<213> Neisseria bacilliformis


<220>
<223> Neisseria bacilliformis ATCC BAA-1200

<400> 341
Met Gln Gln Lys Pro Gln Arg Tyr Ile Leu Gly Leu Asp Leu Gly Ile 
1               5                   10                  15      


Ala Ser Val Gly Trp Ala Cys Val Trp Ala Asp Glu Asn Glu His Pro 
            20                  25                  30          


Thr Gly Leu Leu Asp Cys Gly Val Arg Thr Phe Glu Arg Ala Glu Val 
        35                  40                  45              


Pro Lys Thr Gly Asp Ser Leu Ala Leu Ala Arg Arg Gln Ala Arg Ser 
    50                  55                  60                  


Val Arg Arg Leu Ile Arg Arg Arg Ala His Arg Leu Leu Arg Leu Arg 
65                  70                  75                  80  


Arg Leu Leu Lys Arg Glu Gly Val Leu Leu Ser Ala Asp Phe Asn Glu 
                85                  90                  95      


Asn Gly Leu Val Arg Gly Leu Pro Ile Asp Ala Trp Ala Leu Arg Val 
            100                 105                 110         


Ala Gly Leu Asp Arg Lys Leu Ser Asn Lys Glu Trp Ala Ala Val Leu 
        115                 120                 125             


Leu His Leu Val Lys His Arg Gly Tyr Leu Ser Gln Arg Lys Asn Glu 
    130                 135                 140                 


Thr Gln Ser Lys Asp Lys Glu Leu Gly Arg Leu Leu Ala Gly Val Asn 
145                 150                 155                 160 


Gly Asn Arg Glu Ala Leu Gln Asn Arg Ser Asp Glu Tyr Arg Thr Ala 
                165                 170                 175     


Ala Glu Leu Ala Val Lys Lys Phe Ala Ala Glu Asn Asn Gly Ser Leu 
            180                 185                 190         


Arg Asn Lys Gly Gly Asp Tyr Ser His Thr Phe Asp Arg Lys Asp Leu 
        195                 200                 205             


Gln Arg Glu Leu His Leu Leu Phe Glu Arg Gln Arg Ala Leu Asp Asn 
    210                 215                 220                 


Pro Phe Thr Ser Ser Glu Met Glu Ala Ala Val Asp Glu Leu Leu Met 
225                 230                 235                 240 


Lys Gln Arg Ser Ala Leu Gln Gly Glu Ala Val Leu Lys Met Leu Gly 
                245                 250                 255     


Arg Cys Thr Phe Glu Pro Ser Glu Tyr Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Ser Ala Glu Arg Phe Val Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Gln Tyr Asn Gly Glu Glu Arg Ala Leu Ser Glu Ala Glu Arg Arg Leu 
    290                 295                 300                 


Leu Leu Asp Glu Pro Tyr Gln Lys Ala Lys Leu Thr Tyr Lys Gln Val 
305                 310                 315                 320 


Arg Thr Ile Leu Glu Leu Pro Glu Ser Ala Val Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly His Gly Glu Asp Gly Leu Lys Ala Glu Ser Gly Thr Leu Met 
            340                 345                 350         


Glu Met Lys Ala Tyr His Ala Val Arg Lys Ala Leu Lys Asp Ala Gly 
        355                 360                 365             


Leu Glu Gly Glu Trp Glu Asn Arg Ile Arg Asn Pro Glu Leu Leu Asp 
    370                 375                 380                 


Ala Ile Gly Thr Ala Phe Ser Leu Tyr Lys Thr Asp Glu Asp Ile Arg 
385                 390                 395                 400 


Ala Asn Leu Ala Ala Phe Arg Leu Ser Glu Asn Val Leu Glu Ala Leu 
                405                 410                 415     


Leu Ala Gly Leu Asn Phe Asp Lys Phe Val His Leu Ser Leu Lys Ala 
            420                 425                 430         


Leu Ala Lys Ile Leu Pro Leu Met Glu Gln Gly Met Arg Tyr Asp Glu 
        435                 440                 445             


Ala Cys Lys Glu Ala Tyr Gly Asp His Tyr Gly Ala Lys Glu Gln Glu 
    450                 455                 460                 


Asp His Arg Leu Leu Pro Pro Phe Val Ala Asp Asp Ile Arg Asn Pro 
465                 470                 475                 480 


Val Val Phe Arg Thr Leu Thr Gln Ala Arg Lys Ile Val Asn Glu Ile 
                485                 490                 495     


Val Arg Arg Tyr Gly Ser Pro Leu Arg Val His Ile Glu Thr Gly Arg 
            500                 505                 510         


Glu Val Gly Lys Ser Phe Ser Asp Arg Lys Glu Ile Glu Lys Arg Gln 
        515                 520                 525             


Glu Glu Asn Arg Lys Glu Arg Glu Arg Ala Ala Ala His Phe Lys Glu 
    530                 535                 540                 


Leu Phe Pro Asn Phe Ala Gly Glu Pro Lys Ala Gln Asp Ile Leu Lys 
545                 550                 555                 560 


Leu Arg Leu Tyr Glu Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys 
                565                 570                 575     


Glu Ile Asp Leu Arg Arg Leu Pro Glu Lys Gly Tyr Val Glu Ile Asp 
            580                 585                 590         


His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys 
        595                 600                 605             


Val Leu Val Leu Gly Lys Glu Asn Gln Asp Lys Arg Asn Arg Thr Pro 
    610                 615                 620                 


Tyr Glu Tyr Leu Asp Gly Lys Gly Asn Ser Gly Ala Trp Arg Ala Phe 
625                 630                 635                 640 


Ala Glu Arg Val Ser Gly Cys Arg Phe Pro Tyr Ala Lys Lys Gln Arg 
                645                 650                 655     


Leu Leu Thr Gln Lys Leu Asp Glu Lys Thr Glu Gln Gly Phe Leu Glu 
            660                 665                 670         


Arg Asn Leu Asn Asp Thr Arg Tyr Val Ala Arg Phe Leu Cys Gln Phe 
        675                 680                 685             


Ile Glu Glu Lys Met His Leu Glu Gly Ala Gly Lys Lys Arg Val Phe 
    690                 695                 700                 


Ala Ser Asn Gly Gln Ile Thr Ala Leu Leu Arg Gly Phe Trp Gly Leu 
705                 710                 715                 720 


Lys Lys Val Arg Glu Glu Asn Asp Arg His His Ala Leu Asp Ala Val 
                725                 730                 735     


Val Val Ala Cys Ser Ser Val Ser Met Gln Gln Lys Ile Thr Arg His 
            740                 745                 750         


Phe Arg Tyr Arg Glu Glu Leu Glu His Ile Asp Arg Glu Thr Gly Glu 
        755                 760                 765             


Val Ile His Gly Phe Pro Gln Pro Trp Glu Phe Phe Arg Gln Glu Val 
    770                 775                 780                 


Met Thr Arg Val Phe Ser Asp Asp Pro Val Ser Glu Leu Ala Glu Lys 
785                 790                 795                 800 


Leu Asp Ser Arg Pro Glu Ala Val His Glu Phe Val Thr Pro Leu Phe 
                805                 810                 815     


Val Ser Arg Ala Pro His Arg Lys Val Thr Gly Gln Gly His Leu Glu 
            820                 825                 830         


Thr Ile Arg Ser Ala Lys Arg Leu Asp Glu Lys Ile Ser Val Val Lys 
        835                 840                 845             


Leu Pro Leu Thr Gln Leu Lys Thr Lys Asp Ile Glu Arg Ile Val Gly 
    850                 855                 860                 


Tyr Pro Asn Arg Glu Pro Ala Leu Tyr Asp Ala Leu Ala Ala Arg Leu 
865                 870                 875                 880 


Ala Ala Phe Lys Asp Asp Pro Ala Lys Ala Phe Ser Glu Pro Phe Tyr 
                885                 890                 895     


Lys Thr Gly Lys Asp Gly Lys Cys Gly Val Leu Val Lys Ala Val Arg 
            900                 905                 910         


Val Glu Asn Val Gln Lys Ser Gly Leu Leu Val Arg Lys Asp Glu Ser 
        915                 920                 925             


Gly Lys Met Gln Gly Val Ala Asp Asn Ala Thr Met Val Arg Val Asp 
    930                 935                 940                 


Val Phe Gly Lys Asn Gly Lys Asn Tyr Leu Val Pro Val Tyr Ala Trp 
945                 950                 955                 960 


Gln Val Glu Lys Gly Glu Leu Pro Asn Arg Ala Val Val Ala Tyr Ala 
                965                 970                 975     


Asp Glu Glu Asp Trp Asp Glu Met Asp Asp Ser Phe Glu Phe Lys Phe 
            980                 985                 990         


Ser Leu Tyr Pro Asn Asp Leu Val  Glu Val Val Thr Lys  Lys Asp Lys 
        995                 1000                 1005             


Phe Phe  Gly Tyr Tyr Ser Gly  Phe Asn Arg Ala Thr  Gly Ala Ile 
    1010                 1015                 1020             


Asn Ile  Lys Glu His Asp Leu  Ser Lys Ser Lys Val  Lys Asn Gly 
    1025                 1030                 1035             


Val Tyr  Glu Gly Ile Gly Val  Lys Thr Ala Gln Ser  Phe Gln Lys 
    1040                 1045                 1050             


Tyr Gln  Val Asp Thr Leu Gly  Lys Thr Ile Arg Leu  Cys Lys Pro 
    1055                 1060                 1065             


Glu Lys  Arg Met Gly Phe Lys  Lys Lys 
    1070                 1075         


<210> 342
<211> 1082
<212> PRT
<213> Neisseria cinerea


<220>
<223> Neisseria cinerea ATCC 14685

<400> 342
Met Ala Ala Phe Lys Pro Asn Pro Met Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Ile Val Glu Ile Asp Glu Glu 
            20                  25                  30          


Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Ala Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asp Asn Thr His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Asn Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Asn Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Asp Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Thr Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Val Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Asp Leu Asp Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Val Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Asn Arg Tyr Asp Glu Ala Cys Thr Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ser Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Ala Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Ile Asn Arg Phe Leu Cys Gln Phe Val Ala Asp His Met Leu Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Arg Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Ile Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Ala His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Lys Tyr Val Thr Pro Leu Phe Ile Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Ile Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val His Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Ile Val Arg Val Asp Val Phe Glu Lys Gly Gly Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Gln Gly Lys Asp Glu Glu Asp Trp Thr Val Met Asp 
            980                 985                 990         


Asp Ser Phe Glu Phe Lys Phe Val  Leu Tyr Ala Asn Asp  Leu Ile Lys 
        995                 1000                 1005             


Leu Thr  Ala Lys Lys Asn Glu  Phe Leu Gly Tyr Phe  Val Ser Leu 
    1010                 1015                 1020             


Asn Arg  Ala Thr Gly Ala Ile  Asp Ile Arg Thr His  Asp Thr Asp 
    1025                 1030                 1035             


Ser Thr  Lys Gly Lys Asn Gly  Ile Phe Gln Ser Val  Gly Val Lys 
    1040                 1045                 1050             


Thr Ala  Leu Ser Phe Gln Lys  Tyr Gln Ile Asp Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210> 343
<211> 1081
<212> PRT
<213> Neisseria flavescens


<220>
<223> Neisseria flavescens SK114

<400> 343
Met Thr Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Glu 
            20                  25                  30          


Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Ala Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asp Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Val Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Val Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Ile Ser Asp Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Ala Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


Tyr Cys Thr Phe Glu Pro Thr Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Ile Asp Met Pro Tyr Lys Asn Lys Leu Thr Tyr Ala Lys Ala Arg 
305                 310                 315                 320 


Glu Leu Leu Gly Leu Asp Asp Thr Ala Phe Phe Lys Gly Leu Arg Tyr 
                325                 330                 335     


Gly Lys Asp Asn Ala Glu Ser Ala Thr Leu Met Glu Met Lys Ala Tyr 
            340                 345                 350         


His Ala Ile Arg Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys Lys 
        355                 360                 365             


Ser Pro Leu Ser Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr Ala 
    370                 375                 380                 


Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys Gly 
385                 390                 395                 400 


Cys Leu Gln Pro Glu Ile Leu Asp Ala Leu Leu Lys His Ile Asn Phe 
                405                 410                 415     


Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val Pro 
            420                 425                 430         


Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Thr Tyr 
        435                 440                 445             


Gly Asp His Tyr Gly Glu Lys Asn Ser Glu Glu Met Leu Tyr Leu Pro 
    450                 455                 460                 


Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala Leu 
465                 470                 475                 480 


Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly Ser 
                485                 490                 495     


Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser Phe 
            500                 505                 510         


Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys Asp 
        515                 520                 525             


Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe Val 
    530                 535                 540                 


Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu Gln 
545                 550                 555                 560 


Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Ala Ile Asp Ile Arg Arg 
                565                 570                 575     


Leu Asn Gly Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe Ser 
            580                 585                 590         


Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly Ser 
        595                 600                 605             


Glu Asn Gln Asn Lys Gly Asn Arg Thr Pro Tyr Glu Tyr Leu Asn Gly 
    610                 615                 620                 


Lys Asp Asn Ser Arg Glu Trp Leu Glu Phe Lys Ala Arg Val Glu Thr 
625                 630                 635                 640 


Ser Arg Phe Pro His Ser Lys Lys Gln Arg Val Leu Leu Gln Lys Phe 
                645                 650                 655     


Asp Glu Lys Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr Val 
            660                 665                 670         


Asn Arg Phe Leu Cys Gln Phe Val Ala Asp His Met Gln Leu Thr Gly 
        675                 680                 685             


Lys Gly Lys Arg Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn Leu 
    690                 695                 700                 


Leu Arg Gly Phe Trp Gly Leu His Lys Val Arg Ala Glu Asn Asp Arg 
705                 710                 715                 720 


His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala Met 
                725                 730                 735     


Gln Gln Lys Ile Thr Cys Phe Val Arg Tyr Lys Glu Met Asn Ala Phe 
            740                 745                 750         


Asp Gly Lys Thr Val Asp Lys Glu Thr Gly Glu Val Leu His Gln Lys 
        755                 760                 765             


Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met Ile 
    770                 775                 780                 


Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala Asp 
785                 790                 795                 800 


Thr Pro Glu Lys Leu Arg Ala Leu Leu Ala Glu Lys Leu Ser Ser Arg 
                805                 810                 815     


Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg Ala 
            820                 825                 830         


Pro Asn Arg Lys Met Ser Gly Ala His Lys Asp Thr Leu Arg Ser Ala 
        835                 840                 845             


Lys Arg Phe Val Lys His Asn Glu Lys Ile Ser Val Lys Arg Val Trp 
    850                 855                 860                 


Leu Thr Glu Ile Lys Leu Ala Asp Leu Glu Asn Met Val Asn Tyr Lys 
865                 870                 875                 880 


Asn Gly Arg Glu Ile Glu Leu Tyr Glu Ala Leu Lys Ala Arg Leu Gly 
                885                 890                 895     


Ala Tyr Gly Gly Asn Ala Lys Gln Ala Phe Asp Pro Lys Asp Asn Pro 
            900                 905                 910         


Phe Tyr Lys Lys Gly Gly Gln Leu Val Lys Ala Val Arg Val Glu Lys 
        915                 920                 925             


Thr Gln Glu Ser Gly Val Leu Leu Asn Lys Lys Asn Ala Tyr Thr Ile 
    930                 935                 940                 


Ala Asp Asn Gly Asp Met Val Arg Val Asp Val Phe Cys Lys Val Asp 
945                 950                 955                 960 


Lys Lys Gly Lys Asn Gln Tyr Phe Ile Val Pro Ile Tyr Ala Trp Gln 
                965                 970                 975     


Val Ala Glu Asn Ile Leu Pro Asp Ile Asp Cys Lys Gly Tyr Arg Ile 
            980                 985                 990         


Asp Asp Ser Tyr Thr Phe Cys Phe  Ser Leu His Lys Tyr  Asp Leu Ile 
        995                 1000                 1005             


Ala Phe  Gln Lys Asp Glu Lys  Ser Lys Val Glu Phe  Ala Tyr Tyr 
    1010                 1015                 1020             


Ile Asn  Cys Asp Ser Ser Asn  Gly Arg Phe Tyr Leu  Ala Trp His 
    1025                 1030                 1035             


Asp Lys  Gly Ser Lys Glu Gln  Gln Phe Arg Ile Ser  Thr Gln Asn 
    1040                 1045                 1050             


Leu Val  Leu Met Gln Lys Tyr  Gln Ile Asp Glu Leu  Gly Lys Glu 
    1055                 1060                 1065             


Ile Arg  Pro Cys Arg Leu Lys  Lys Arg Pro Pro Val  Arg 
    1070                 1075                 1080     


<210> 344
<211> 1082
<212> PRT
<213> Neisseria lactamica

<400> 344
Met Ala Ala Phe Lys Pro Asn Pro Met Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Lys Glu 
            20                  25                  30          


Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Asp Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Val Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Cys Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asp Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Asn Leu Leu Phe Glu Lys Gln Lys Glu Phe Ser Asn 
    210                 215                 220                 


Pro His Val Ser Asp Ser Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Ala Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Pro Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Thr Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Lys Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Val Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Cys Lys Lys Asn Ala Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Cys Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Val 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Glu Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp His Ile Leu Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Arg Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Ala His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Ile Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Gly Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Asp Ala Leu Lys Ala Gln Leu Glu Thr His Lys 
                885                 890                 895     


Asp Asn Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Ile Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Gly Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Ala Phe Lys Asp Glu Glu Asp Trp Thr Val Met Asp 
            980                 985                 990         


Asp Ser Phe Glu Phe Arg Phe Val  Leu Tyr Ala Asn Asp  Leu Ile Lys 
        995                 1000                 1005             


Leu Thr  Ala Lys Lys Asn Glu  Phe Leu Gly Tyr Phe  Val Ser Leu 
    1010                 1015                 1020             


Asn Arg  Ala Thr Gly Ala Ile  Asp Ile Arg Thr His  Asp Thr Asp 
    1025                 1030                 1035             


Ser Thr  Lys Gly Lys Asn Gly  Ile Phe Gln Ser Val  Gly Val Lys 
    1040                 1045                 1050             


Thr Ala  Leu Ser Phe Gln Lys  Asn Gln Ile Asp Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210> 345
<211> 1082
<212> PRT
<213> Neisseria meningitidis

<400> 345
Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Asp 
            20                  25                  30          


Glu Asn Pro Ile Cys Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asp Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Asn Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Ile Ser Asp Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Thr Thr 
    290                 295                 300                 


Leu Ile Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Glu Leu Asp Asn Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Val Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Asp Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Thr Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Glu Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp His Met Leu Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Arg Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Gln Gly Lys Asp Glu Glu Asp Trp Gln Leu Ile Asp 
            980                 985                 990         


Asp Ser Phe Asn Phe Lys Phe Ser  Leu His Pro Asn Asp  Leu Val Glu 
        995                 1000                 1005             


Val Ile  Thr Lys Lys Ala Arg  Met Phe Gly Tyr Phe  Ala Ser Cys 
    1010                 1015                 1020             


His Arg  Gly Thr Gly Asn Ile  Asn Ile Arg Ile His  Asp Leu Asp 
    1025                 1030                 1035             


His Lys  Ile Gly Lys Asn Gly  Ile Leu Glu Gly Ile  Gly Val Lys 
    1040                 1045                 1050             


Thr Ala  Leu Ser Phe Gln Lys  Tyr Gln Ile Asp Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210> 346
<211> 1082
<212> PRT
<213> Neisseria meningitidis


<220>
<223> Neisseria meningitidis 2007056

<400> 346
Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Asp 
            20                  25                  30          


Glu Asn Pro Ile Cys Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asp Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Ile Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp Arg Met Arg Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Gln Gly Lys Asp Glu Glu Asp Trp Gln Leu Ile Asp 
            980                 985                 990         


Asp Ser Phe Asn Phe Lys Phe Ser  Leu His Pro Asn Asp  Leu Val Glu 
        995                 1000                 1005             


Val Ile  Thr Lys Lys Ala Arg  Met Phe Gly Tyr Phe  Ala Ser Cys 
    1010                 1015                 1020             


His Arg  Gly Thr Gly Asn Ile  Asn Ile Arg Ile His  Asp Leu Asp 
    1025                 1030                 1035             


His Lys  Ile Gly Lys Asn Gly  Ile Leu Glu Gly Ile  Gly Val Lys 
    1040                 1045                 1050             


Thr Ala  Leu Ser Phe Gln Lys  Tyr Gln Ile Asp Glu  Leu Gly Glu 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210> 347
<211> 1082
<212> PRT
<213> Neisseria meningitidis


<220>
<223> Neisseria meningitidis 63049

<400> 347
Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Glu 
            20                  25                  30          


Glu Asn Pro Ile Arg Leu Ile Asp Leu Ser Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asp Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Val Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Arg Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Val Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Ala Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp Arg Met Arg Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Gln Gly Lys Asp Glu Glu Asp Trp Gln Leu Ile Asp 
            980                 985                 990         


Asp Ser Phe Asn Phe Lys Phe Ser  Leu His Pro Asn Asp  Leu Val Glu 
        995                 1000                 1005             


Val Ile  Thr Lys Lys Ala Arg  Met Phe Gly Tyr Phe  Ala Ser Cys 
    1010                 1015                 1020             


His Arg  Gly Thr Gly Asn Ile  Asn Ile Arg Ile His  Asp Leu Asp 
    1025                 1030                 1035             


His Lys  Ile Gly Lys Asn Gly  Ile Leu Glu Gly Ile  Gly Val Lys 
    1040                 1045                 1050             


Thr Ala  Leu Ser Phe Gln Lys  Tyr Gln Ile Asp Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210> 348
<211> 1082
<212> PRT
<213> Neisseria meningitidis

<400> 348
Met Ala Ala Phe Lys Pro Asn Ser Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Glu 
            20                  25                  30          


Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Thr Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asn 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Gly Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Ser Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Ile Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp Arg Met Arg Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Leu Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Gln Gly Lys Asp Glu Glu Asp Trp Gln Leu Ile Asp 
            980                 985                 990         


Asp Ser Phe Asn Phe Lys Phe Ser  Leu His Pro Asn Asp  Leu Val Glu 
        995                 1000                 1005             


Val Ile  Thr Lys Lys Ala Arg  Met Phe Gly Tyr Phe  Ala Ser Cys 
    1010                 1015                 1020             


His Arg  Gly Thr Gly Asn Ile  Asn Ile Arg Ile His  Asp Leu Asp 
    1025                 1030                 1035             


His Lys  Ile Gly Lys Asn Gly  Ile Leu Glu Gly Ile  Gly Val Lys 
    1040                 1045                 1050             


Thr Ala  Leu Ser Phe Gln Lys  Tyr Gln Ile Asp Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210> 349
<211> 1082
<212> PRT
<213> Neisseria meningitidis


<220>
<223> Neisseria meningitidis 92045

<400> 349
Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Glu 
            20                  25                  30          


Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asp Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Cys Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Asn Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Ile Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Val 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Glu Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp His Ile Leu Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Arg Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Gly Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Gln Gly Lys Asp Glu Glu Asp Trp Gln Leu Ile Asp 
            980                 985                 990         


Asp Ser Phe Asn Phe Lys Phe Ser  Leu His Pro Asn Asp  Leu Val Glu 
        995                 1000                 1005             


Val Ile  Thr Lys Lys Ala Arg  Met Phe Gly Tyr Phe  Ala Ser Cys 
    1010                 1015                 1020             


His Arg  Gly Thr Gly Asn Ile  Asn Ile Arg Ile His  Asp Leu Asp 
    1025                 1030                 1035             


His Lys  Ile Gly Lys Asn Gly  Ile Leu Glu Gly Ile  Gly Val Lys 
    1040                 1045                 1050             


Thr Ala  Leu Ser Phe Gln Lys  Tyr Gln Ile Asp Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210> 350
<211> 1081
<212> PRT
<213> Neisseria meningitidis


<220>
<223> Neisseria meningitidis 93003

<400> 350
Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Glu 
            20                  25                  30          


Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asp Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Val Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Glu Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Thr Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Ala Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Val 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Glu Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp Arg Met Arg Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu His Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Ile Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Ala His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Ile Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Ala Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Ala Gly Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Ala Tyr Ala Asp Glu Glu Asp Trp Thr Val Ile Asp 
            980                 985                 990         


Glu Ser Phe Arg Phe Lys Phe Val  Leu Tyr Ser Asn Asp  Leu Ile Lys 
        995                 1000                 1005             


Val Gln  Leu Lys Lys Asp Ser  Phe Leu Gly Tyr Phe  Ser Gly Leu 
    1010                 1015                 1020             


Asp Arg  Ala Thr Gly Ala Ile  Ser Leu Arg Glu His  Asp Leu Glu 
    1025                 1030                 1035             


Lys Ser  Lys Gly Lys Asp Gly  Met His Arg Ile Gly  Val Lys Thr 
    1040                 1045                 1050             


Ala Leu  Ser Phe Gln Lys Tyr  Gln Ile Asp Glu Met  Gly Lys Glu 
    1055                 1060                 1065             


Ile Arg  Pro Cys Arg Leu Lys  Lys Arg Pro Pro Val  Arg 
    1070                 1075                 1080     


<210> 351
<211> 1081
<212> PRT
<213> Neisseria meningitidis


<220>
<223> Neisseria meningitidis 93004

<400> 351
Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Asp 
            20                  25                  30          


Glu Asn Pro Ile Cys Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asp Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Lys Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Asn Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Ile Ser Asp Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Thr Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Val Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Gln Pro Leu Thr Asp Thr Gln Arg Ala Lys 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Val Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asn Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Gln Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp Arg Met Arg Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Ala Tyr Ala Asp Glu Glu Asp Trp Thr Val Ile Asp 
            980                 985                 990         


Glu Ser Phe Arg Phe Lys Phe Val  Leu Tyr Ser Asn Asp  Leu Ile Lys 
        995                 1000                 1005             


Val Gln  Leu Lys Lys Asp Ser  Phe Leu Gly Tyr Phe  Ser Gly Leu 
    1010                 1015                 1020             


Asp Arg  Ala Thr Gly Ala Ile  Ser Leu Arg Glu His  Asp Leu Glu 
    1025                 1030                 1035             


Lys Ser  Lys Gly Lys Asp Gly  Met His Arg Ile Gly  Val Lys Thr 
    1040                 1045                 1050             


Ala Leu  Ser Phe Gln Lys Tyr  Gln Ile Asp Glu Met  Gly Lys Glu 
    1055                 1060                 1065             


Ile Arg  Pro Cys Arg Leu Lys  Lys Arg Pro Pro Val  Arg 
    1070                 1075                 1080     


<210> 352
<211> 1082
<212> PRT
<213> Neisseria meningitidis


<220>
<223> Neisseria meningitidis 96023

<400> 352
Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Asp 
            20                  25                  30          


Glu Asn Pro Ile Cys Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asp Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Ser Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Ile Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Tyr Gln Phe Val Ala Asp Arg Met Arg Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Gln Gly Lys Asp Glu Glu Asp Trp Gln Leu Ile Asp 
            980                 985                 990         


Asp Ser Phe Asn Phe Lys Phe Ser  Leu His Pro Asn Asp  Leu Val Glu 
        995                 1000                 1005             


Val Ile  Thr Lys Lys Ala Arg  Met Phe Gly Tyr Phe  Ala Ser Cys 
    1010                 1015                 1020             


His Arg  Gly Thr Gly Asn Ile  Asn Ile Arg Ile His  Asp Leu Asp 
    1025                 1030                 1035             


His Lys  Ile Gly Lys Asn Gly  Ile Leu Glu Gly Ile  Gly Val Lys 
    1040                 1045                 1050             


Thr Ala  Leu Ser Phe Gln Lys  Tyr Gln Ile Asp Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210> 353
<211> 1081
<212> PRT
<213> Neisseria meningitidis


<220>
<223> Neisseria meningitidis 98008

<400> 353
Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Asp 
            20                  25                  30          


Glu Asn Pro Ile Cys Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Ala Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ser Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asn Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Ile Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp Arg Met Arg Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Ala Gly Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Ala Tyr Ala Asp Glu Glu Gly Trp Thr Val Ile Asp 
            980                 985                 990         


Glu Ser Phe Arg Phe Lys Phe Val  Leu Tyr Ser Asn Asp  Leu Ile Lys 
        995                 1000                 1005             


Val Gln  Leu Lys Lys Asp Ser  Phe Leu Gly Tyr Phe  Ser Gly Leu 
    1010                 1015                 1020             


Asp Arg  Ala Thr Gly Ala Ile  Ser Leu Arg Glu His  Asp Leu Glu 
    1025                 1030                 1035             


Lys Ser  Lys Gly Lys Asp Gly  Met His Arg Ile Gly  Val Lys Thr 
    1040                 1045                 1050             


Ala Leu  Ser Phe Gln Lys Tyr  Gln Ile Asp Glu Met  Gly Lys Glu 
    1055                 1060                 1065             


Ile Arg  Leu Cys Arg Leu Lys  Lys Arg Pro Pro Val  Arg 
    1070                 1075                 1080     


<210> 354
<211> 1082
<212> PRT
<213> Neisseria meningitidis

<400> 354
Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Glu 
            20                  25                  30          


Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Val Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asp Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Ile Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Ile Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp Arg Met Arg Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Gln Gly Lys Asp Glu Glu Asp Trp Gln Leu Ile Asp 
            980                 985                 990         


Asp Ser Phe Asn Phe Lys Phe Ser  Leu His Pro Asn Asp  Leu Val Glu 
        995                 1000                 1005             


Val Ile  Thr Lys Lys Ala Arg  Met Phe Gly Tyr Phe  Ala Ser Cys 
    1010                 1015                 1020             


His Arg  Gly Thr Gly Asn Ile  Asn Ile Arg Ile His  Asp Leu Asp 
    1025                 1030                 1035             


His Lys  Ile Gly Lys Asn Gly  Ile Leu Glu Gly Ile  Gly Val Lys 
    1040                 1045                 1050             


Thr Ala  Leu Ser Phe Gln Lys  Tyr Gln Ile Asp Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210> 355
<211> 1082
<212> PRT
<213> Neisseria meningitidis


<220>
<223> Neisseria meningitidis alpha275

<400> 355
Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Asp 
            20                  25                  30          


Glu Asn Pro Ile Cys Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Ala Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asp Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Val Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp Arg Met Arg Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Gln Gly Lys Asp Glu Glu Asp Trp Gln Leu Ile Asp 
            980                 985                 990         


Asp Ser Phe Asn Phe Lys Phe Ser  Leu His Pro Asn Asp  Leu Val Glu 
        995                 1000                 1005             


Val Ile  Thr Lys Lys Ala Arg  Met Phe Gly Tyr Phe  Ala Ser Cys 
    1010                 1015                 1020             


His Arg  Gly Thr Gly Asn Ile  Asn Ile Arg Ile His  Asp Leu Asp 
    1025                 1030                 1035             


His Lys  Ile Gly Lys Asn Gly  Ile Leu Glu Gly Ile  Gly Val Lys 
    1040                 1045                 1050             


Thr Ala  Leu Ser Phe Gln Lys  Tyr Gln Ile Asp Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210> 356
<211> 1082
<212> PRT
<213> Neisseria meningitidis


<220>
<223> Neisseria meningitidis ATCC 13091

<400> 356
Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Glu 
            20                  25                  30          


Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Thr Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asn 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Leu Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Gly Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Asn Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Ile Ser Asp Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Thr Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Thr Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Glu Leu Asp Asp Ile Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Ile Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Asn 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Asp Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile His Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp Arg Met Arg Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Thr Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Ile Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Met Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Gln Gly Lys Asp Glu Glu Asp Trp Gln Leu Ile Asp 
            980                 985                 990         


Asp Ser Phe Asn Phe Lys Phe Ser  Leu His Pro Asn Asp  Leu Val Glu 
        995                 1000                 1005             


Val Ile  Thr Lys Lys Ala Arg  Met Phe Gly Tyr Phe  Ala Ser Cys 
    1010                 1015                 1020             


His Arg  Gly Thr Gly Asn Ile  Asn Ile Arg Ile His  Asp Leu Asp 
    1025                 1030                 1035             


His Lys  Ile Gly Lys Asn Gly  Ile Leu Glu Gly Ile  Gly Val Lys 
    1040                 1045                 1050             


Thr Ala  Leu Ser Phe Gln Lys  Tyr Gln Ile Asp Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210> 357
<211> 1081
<212> PRT
<213> Neisseria meningitidis


<220>
<223> Neisseria meningitidis N1568

<400> 357
Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Glu 
            20                  25                  30          


Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asp Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Cys Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Asn Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Ser Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Thr Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Ile Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp Arg Met Arg Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Ala Tyr Ala Asp Glu Glu Asp Trp Thr Val Ile Asp 
            980                 985                 990         


Glu Ser Phe Arg Phe Lys Phe Val  Leu Tyr Ser Asn Asp  Leu Ile Lys 
        995                 1000                 1005             


Val Gln  Leu Lys Lys Asp Ser  Phe Leu Gly Tyr Phe  Ser Gly Leu 
    1010                 1015                 1020             


Asp Arg  Ala Thr Gly Ala Ile  Ser Leu Arg Glu His  Asp Leu Glu 
    1025                 1030                 1035             


Lys Ser  Lys Gly Lys Asp Gly  Met His Arg Ile Gly  Val Lys Thr 
    1040                 1045                 1050             


Ala Leu  Ser Phe Gln Lys Tyr  Gln Ile Asp Glu Met  Gly Lys Glu 
    1055                 1060                 1065             


Ile Arg  Pro Cys Arg Leu Lys  Lys Arg Pro Pro Val  Arg 
    1070                 1075                 1080     


<210> 358
<211> 1081
<212> PRT
<213> Neisseria meningitidis


<220>
<223> Neisseria meningitidis NM140

<400> 358
Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Asp 
            20                  25                  30          


Glu Asn Pro Ile Cys Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Ala Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ser Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asp Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Arg Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Asp Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Ile Ser Asp Asp Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Thr Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Val Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Glu Leu Asp Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Val Gln Pro Glu Ile Leu Glu Val Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Asp Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Ala Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Glu Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp His Met Leu Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Arg Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asn 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Ala Gly Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Ala Tyr Ala Asp Glu Glu Gly Trp Thr Val Ile Asp 
            980                 985                 990         


Glu Ser Phe Arg Phe Lys Phe Val  Leu Tyr Ser Asn Asp  Leu Ile Lys 
        995                 1000                 1005             


Val Gln  Leu Lys Lys Asp Ser  Phe Leu Gly Tyr Phe  Ser Gly Leu 
    1010                 1015                 1020             


Asp Arg  Ala Thr Gly Ala Ile  Ser Leu Arg Glu His  Asp Leu Glu 
    1025                 1030                 1035             


Lys Ser  Lys Gly Lys Asp Gly  Met His Arg Ile Gly  Val Lys Thr 
    1040                 1045                 1050             


Ala Leu  Ser Phe Gln Lys Tyr  Gln Ile Asp Glu Met  Gly Lys Glu 
    1055                 1060                 1065             


Ile Arg  Leu Cys Arg Leu Lys  Lys Arg Pro Pro Val  Arg 
    1070                 1075                 1080     


<210> 359
<211> 1082
<212> PRT
<213> Neisseria meningitidis


<220>
<223> Neisseria meningitidis NM220

<400> 359
Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Glu 
            20                  25                  30          


Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asn Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Ser Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Val Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Val 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Cys Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp His Ile Leu Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Arg Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Lys Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Ala His Lys Asp Thr Leu Arg Ser 
        835                 840                 845             


Ala Lys Arg Phe Val Lys His Asn Glu Lys Ile Ser Val Lys Arg Val 
    850                 855                 860                 


Trp Leu Thr Glu Ile Lys Leu Ala Asp Leu Glu Asn Met Val Asn Tyr 
865                 870                 875                 880 


Lys Asn Gly Arg Glu Ile Glu Leu Tyr Glu Ala Leu Lys Ala Arg Leu 
                885                 890                 895     


Glu Ala Tyr Gly Gly Asn Ala Lys Gln Ala Phe Asp Pro Lys Asp Asn 
            900                 905                 910         


Pro Phe Tyr Lys Lys Gly Gly Gln Leu Val Lys Ala Val Arg Val Glu 
        915                 920                 925             


Lys Thr Gln Glu Ser Gly Val Leu Leu Asn Lys Lys Asn Ala Tyr Thr 
    930                 935                 940                 


Ile Ala Asp Asn Gly Asp Met Val Arg Val Asp Val Phe Cys Lys Val 
945                 950                 955                 960 


Asp Lys Lys Gly Lys Asn Gln Tyr Phe Ile Val Pro Ile Tyr Ala Trp 
                965                 970                 975     


Gln Val Ala Glu Asn Ile Leu Pro Asp Ile Asp Cys Lys Gly Tyr Arg 
            980                 985                 990         


Ile Asp Asp Ser Tyr Thr Phe Cys  Phe Ser Leu His Lys  Tyr Asp Leu 
        995                 1000                 1005             


Ile Ala  Phe Gln Lys Asp Glu  Lys Ser Lys Val Glu  Phe Ala Tyr 
    1010                 1015                 1020             


Tyr Ile  Asn Cys Asp Ser Ser  Asn Gly Arg Phe Tyr  Leu Ala Trp 
    1025                 1030                 1035             


His Asp  Lys Gly Ser Lys Glu  Gln Gln Phe Arg Ile  Ser Thr Gln 
    1040                 1045                 1050             


Asn Leu  Val Leu Ile Gln Lys  Tyr Gln Val Asn Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210> 360
<211> 1082
<212> PRT
<213> Neisseria meningitidis


<220>
<223> Neisseria meningitidis NM233

<400> 360
Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Glu 
            20                  25                  30          


Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asn Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Ser Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Val Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Lys Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Val 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Cys Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp His Ile Leu Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Arg Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Lys Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Ala His Lys Asp Thr Leu Arg Ser 
        835                 840                 845             


Ala Lys Arg Phe Val Lys His Asn Glu Lys Ile Ser Val Lys Arg Val 
    850                 855                 860                 


Trp Leu Thr Glu Ile Lys Leu Ala Asp Leu Glu Asn Met Val Asn Tyr 
865                 870                 875                 880 


Lys Asn Gly Arg Glu Ile Glu Leu Tyr Glu Ala Leu Lys Ala Arg Leu 
                885                 890                 895     


Glu Ala Tyr Gly Gly Asn Ala Lys Gln Ala Phe Asp Pro Lys Asp Asn 
            900                 905                 910         


Pro Phe Tyr Lys Lys Gly Gly Gln Leu Val Lys Ala Val Arg Val Glu 
        915                 920                 925             


Lys Thr Gln Glu Ser Gly Val Leu Leu Asn Lys Lys Asn Ala Tyr Thr 
    930                 935                 940                 


Ile Ala Asp Asn Gly Asp Met Val Arg Val Asp Val Phe Cys Lys Val 
945                 950                 955                 960 


Asp Lys Lys Gly Lys Asn Gln Tyr Phe Ile Val Pro Ile Tyr Ala Trp 
                965                 970                 975     


Gln Val Ala Glu Asn Ile Leu Pro Asp Ile Asp Cys Lys Gly Tyr Arg 
            980                 985                 990         


Ile Asp Asp Ser Tyr Thr Phe Cys  Phe Ser Leu His Lys  Tyr Asp Leu 
        995                 1000                 1005             


Ile Ala  Phe Gln Lys Asp Glu  Lys Ser Lys Val Glu  Phe Ala Tyr 
    1010                 1015                 1020             


Tyr Ile  Asn Cys Asp Ser Ser  Asn Gly Arg Phe Tyr  Leu Ala Trp 
    1025                 1030                 1035             


His Asp  Lys Gly Ser Lys Glu  Gln Gln Phe Arg Ile  Ser Thr Gln 
    1040                 1045                 1050             


Asn Leu  Val Leu Ile Gln Lys  Tyr Gln Val Asn Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210> 361
<211> 1082
<212> PRT
<213> Neisseria meningitidis

<400> 361
Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Asp 
            20                  25                  30          


Glu Asn Pro Ile Cys Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asp Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Ser Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Ile Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp Arg Met Arg Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Gln Gly Lys Asp Glu Glu Asp Trp Gln Leu Ile Asp 
            980                 985                 990         


Asp Ser Phe Asn Phe Lys Phe Ser  Leu His Pro Asn Asp  Leu Val Glu 
        995                 1000                 1005             


Val Ile  Thr Lys Lys Ala Arg  Met Phe Gly Tyr Phe  Ala Ser Cys 
    1010                 1015                 1020             


His Arg  Gly Thr Gly Asn Ile  Asn Ile Arg Ile His  Asp Leu Asp 
    1025                 1030                 1035             


His Lys  Ile Gly Lys Asn Gly  Ile Leu Glu Gly Ile  Gly Val Lys 
    1040                 1045                 1050             


Thr Ala  Leu Ser Phe Gln Lys  Tyr Gln Ile Asp Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210> 362
<211> 1082
<212> PRT
<213> Neisseria meningitidis

<400> 362
Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Asp 
            20                  25                  30          


Glu Asn Pro Ile Cys Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asp Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Ile Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp Arg Met Arg Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Gln Gly Lys Asp Glu Glu Asp Trp Gln Leu Ile Asp 
            980                 985                 990         


Asp Ser Phe Asn Phe Lys Phe Ser  Leu His Pro Asn Asp  Leu Val Glu 
        995                 1000                 1005             


Val Ile  Thr Lys Lys Ala Arg  Met Phe Gly Tyr Phe  Ala Ser Cys 
    1010                 1015                 1020             


His Arg  Gly Thr Gly Asn Ile  Asn Ile Arg Ile His  Asp Leu Asp 
    1025                 1030                 1035             


His Lys  Ile Gly Lys Asn Gly  Ile Leu Glu Gly Ile  Gly Val Lys 
    1040                 1045                 1050             


Thr Ala  Leu Ser Phe Gln Lys  Tyr Gln Ile Asp Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210> 363
<211> 1089
<212> PRT
<213> Neisseria sp.


<220>
<223> Neisseria sp. oral taxon 014 str. F0314

<400> 363
Met Thr Ala Phe Lys Pro Asn Pro Leu Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Asp Lys 
            20                  25                  30          


Glu Asn Pro Val Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Met Pro Lys Thr Gly Asp Ser Leu Ala Ala Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys His Glu Gly Val Leu Lys Pro Glu Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Val Lys Pro Leu Pro Tyr Ile Pro Lys Gln 
            100                 105                 110         


Pro Arg Asn Thr Pro Trp Gln Leu Arg Ala Ala Ala Leu Asp Arg Lys 
        115                 120                 125             


Leu Thr Pro Leu Glu Trp Ala Ala Val Leu Leu His Leu Val Lys His 
    130                 135                 140                 


Arg Gly Tyr Leu Ser Gln Arg Lys Asn Glu Gly Glu Thr Asp Asp Lys 
145                 150                 155                 160 


Glu Leu Gly Ala Leu Leu Lys Gly Val Ala Asp Asn Thr His Ala Leu 
                165                 170                 175     


Gln Ala Gly Asn Phe Arg Thr Pro Ala Glu Leu Ala Leu Asn Lys Phe 
            180                 185                 190         


Glu Lys Glu Ser Gly His Ile Arg Asn Gln Arg Gly Asp Tyr Ser His 
        195                 200                 205             


Thr Phe Ser Arg Lys Asp Leu Gln Ala Glu Leu Val Leu Leu Phe Glu 
    210                 215                 220                 


Lys Gln Lys Glu Phe Gly Asn Pro Tyr Val Ser Asp Asp Leu Lys Asn 
225                 230                 235                 240 


Gly Ile Glu Asn Leu Leu Met Thr Gln Arg Pro Ala Leu Ser Gly Asp 
                245                 250                 255     


Ala Ile Gln Lys Met Leu Gly His Cys Thr Phe Glu Pro Ala Glu Pro 
            260                 265                 270         


Lys Ala Ala Lys Asn Thr Tyr Thr Ala Glu Arg Phe Ile Trp Leu Thr 
        275                 280                 285             


Lys Leu Asn Asn Leu Arg Ile Leu Asn Gln Gly Asn Glu Arg Pro Leu 
    290                 295                 300                 


Thr Asp Ala Glu Arg Thr Thr Leu Met Asp Glu Pro Tyr Lys Lys Ser 
305                 310                 315                 320 


Lys Leu Thr Tyr Ala Gln Ala Arg Lys Leu Leu Asp Leu Asp Asp Thr 
                325                 330                 335     


Ala Phe Phe Lys Gly Leu Arg Tyr Gly Lys Asp Asn Ala Glu Ser Ala 
            340                 345                 350         


Thr Leu Met Glu Met Lys Ala Tyr His Ala Ile Ser Arg Ala Leu Glu 
        355                 360                 365             


Lys Glu Gly Leu Lys Asp Lys Lys Ser Pro Leu Ser Leu Ser Pro Glu 
    370                 375                 380                 


Leu Gln Asp Glu Ile Gly Thr Ala Phe Ser Leu Phe Lys Thr Asp Glu 
385                 390                 395                 400 


Glu Ile Thr Gly Arg Leu Lys Gly Cys Leu Gln Pro Glu Ile Leu Asp 
                405                 410                 415     


Ala Leu Leu Lys His Ile Ser Phe Asp Lys Phe Val Gln Ile Ser Leu 
            420                 425                 430         


Lys Ala Leu Arg Arg Ile Val Pro Leu Met Glu Gln Gly Lys Arg Tyr 
        435                 440                 445             


Asp Glu Ala Cys Ala Glu Ile Tyr Gly Asp His His Gly Arg Arg Asn 
    450                 455                 460                 


Ser Glu Glu Thr Leu Tyr Leu Pro Pro Ile Pro Ala Asp Glu Ile Arg 
465                 470                 475                 480 


Asn Pro Val Val Leu Arg Ala Leu Ser Gln Ala Arg Lys Val Ile Asn 
                485                 490                 495     


Gly Val Gly Arg Arg Tyr Gly Ser Pro Ala Arg Ile His Ile Glu Thr 
            500                 505                 510         


Ala Arg Glu Val Gly Lys Ser Phe Lys Asp Arg Lys Glu Ile Glu Lys 
        515                 520                 525             


Arg Gln Glu Glu Asn Arg Lys Asp Arg Glu Lys Ala Ala Ala Glu Phe 
    530                 535                 540                 


Gln Glu Tyr Phe Pro Asn Phe Val Gly Glu Pro Lys Ser Lys Asp Ile 
545                 550                 555                 560 


Leu Lys Leu Arg Leu Tyr Arg Gln Gln Asn Cys Lys Cys Leu Tyr Ser 
                565                 570                 575     


Gly Lys Glu Ile Asn Leu Gly Arg Leu Asn Glu Lys Gly Tyr Val Glu 
            580                 585                 590         


Ile Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp Ser Phe Asn 
        595                 600                 605             


Asn Lys Val Leu Val Leu Gly Ser Glu Asn Gln Asn Lys Gly Asn Arg 
    610                 615                 620                 


Thr Pro Tyr Glu Tyr Leu Asn Gly Lys Asp Asn Ser Arg Glu Trp Gln 
625                 630                 635                 640 


Glu Phe Lys Ala Arg Val Glu Thr Ser Arg Phe Pro His Ser Lys Lys 
                645                 650                 655     


Gln Arg Ile Leu Leu Gln Lys Phe Asp Glu Glu Gly Phe Lys Glu Arg 
            660                 665                 670         


Asn Leu Asn Asp Thr Arg Tyr Val Asn Arg Phe Leu Cys Lys Phe Val 
        675                 680                 685             


Ala Asp His Met Gln Leu Thr Gly Lys Gly Lys Arg Arg Val Phe Ala 
    690                 695                 700                 


Ser Asn Gly Gln Ile Thr Asn Leu Leu Arg Gly Phe Trp Gly Leu Arg 
705                 710                 715                 720 


Lys Val Arg Ala Glu Asn Asp Arg His His Ala Leu Asp Ala Val Val 
                725                 730                 735     


Val Ala Cys Ser Thr Val Ala Met Gln Gln Arg Ile Thr Arg Phe Val 
            740                 745                 750         


Arg Tyr Lys Glu Met Asn Ala Phe Asp Gly Lys Thr Val Asp Lys Glu 
        755                 760                 765             


Thr Gly Glu Val Leu His Gln Lys Thr His Phe Pro Gln Pro Trp Glu 
    770                 775                 780                 


Phe Phe Ala Gln Glu Val Met Ile Arg Val Phe Gly Lys Pro Asp Gly 
785                 790                 795                 800 


Lys Pro Glu Leu Glu Glu Ala Asp Thr Pro Glu Lys Leu Arg Ala Leu 
                805                 810                 815     


Leu Ala Glu Lys Leu Ser Ser Arg Pro Glu Ala Val His Glu Tyr Val 
            820                 825                 830         


Ala Pro Leu Phe Val Ser Arg Ala Pro Asn Arg Lys Met Ser Gly Gln 
        835                 840                 845             


Gly His Met Glu Thr Ile Lys Ser Pro Lys Arg Leu Asp Glu Gly Ile 
    850                 855                 860                 


Ser Val Val Arg Val Pro Leu Thr Gln Leu Lys Leu Lys Asp Leu Glu 
865                 870                 875                 880 


Lys Met Val Asn Arg Glu Arg Glu Pro Lys Leu Tyr Glu Ala Leu Lys 
                885                 890                 895     


Ala Arg Leu Glu Ala His Lys Asp Asp Pro Ala Lys Ala Phe Ala Glu 
            900                 905                 910         


Pro Phe Tyr Lys Gln Asp Lys Ala Gly Asn Arg Thr Gln Gln Val Lys 
        915                 920                 925             


Ala Val Arg Ile Glu Gln Val Gln Lys Thr Gly Val Trp Val Arg Asn 
    930                 935                 940                 


Gln Asn Gly Ile Ala Asp Asn Ala Thr Met Val Arg Val Asp Val Phe 
945                 950                 955                 960 


Glu Lys Gly Gly Lys Tyr Tyr Leu Val Pro Ile Tyr Ser Trp Gln Val 
                965                 970                 975     


Ala Lys Gly Ile Leu Pro Asp Lys Ala Ile Ile Ala Phe Lys Asp Glu 
            980                 985                 990         


Glu Glu Trp Gln Leu Ile Asp Asp  Ser Phe Asn Phe Lys  Phe Pro Leu 
        995                 1000                 1005             


His Pro  Asn Asp Leu Val Glu  Val Ile Thr Lys Lys  Ala Arg Ile 
    1010                 1015                 1020             


Phe Gly  Tyr Phe Ala Ser Cys  His Arg Gly Thr Gly  Asn Ile Asn 
    1025                 1030                 1035             


Ile Arg  Ile His Asp Leu Asp  Asn Lys Val Gly Lys  Asn Gly Ile 
    1040                 1045                 1050             


Leu Glu  Gly Ile Gly Val Lys  Thr Ala Leu Ser Phe  Gln Lys Tyr 
    1055                 1060                 1065             


Gln Ile  Asp Glu Leu Gly Lys  Glu Ile Arg Pro Cys  Arg Leu Lys 
    1070                 1075                 1080             


Lys Arg  Pro Pro Val Arg 
    1085                 


<210> 364
<211> 1097
<212> PRT
<213> Neisseria wadsworthii


<220>
<223> Neisseria wadsworthii 9715

<400> 364
Met Lys Lys Gln Pro Gln Arg Tyr Ile Leu Gly Leu Asp Leu Gly Ile 
1               5                   10                  15      


Ala Ser Val Gly Trp Ala Leu Ile Leu Val Asp Gly Ala Glu Asn Pro 
            20                  25                  30          


Val Gly Leu Leu Asp Cys Gly Val Arg Thr Phe Glu Arg Ala Glu Val 
        35                  40                  45              


Pro Lys Thr Gly Asp Ser Leu Ala Leu Ala Arg Arg Gln Ala Arg Ser 
    50                  55                  60                  


Val Arg Arg Leu Ile Arg Arg Arg Ala His Arg Leu Leu Arg Leu Arg 
65                  70                  75                  80  


Arg Leu Leu Lys Arg Glu Gly Ile Leu Ser Ala Ala Asp Phe Asn Ser 
                85                  90                  95      


Asp Gly Leu Pro Asn Leu Pro Ile Asp Ala Trp Gln Leu Arg Val Ala 
            100                 105                 110         


Gly Leu Glu Arg Lys Leu Thr Asn Gln Glu Trp Ala Ala Val Leu Leu 
        115                 120                 125             


His Leu Val Lys His Arg Gly Tyr Leu Ser Gln Arg Lys Ser Glu Thr 
    130                 135                 140                 


Gln Thr Glu Asn Lys Glu Leu Gly Arg Leu Leu Ala Gly Val Ala Glu 
145                 150                 155                 160 


Asn Ser Lys Leu Leu Ser Glu Ser Ser Glu Gln Tyr Arg Thr Pro Ala 
                165                 170                 175     


Glu Leu Ala Val Lys Leu Phe Ala Glu Gln Ser Gly His Leu Arg Asn 
            180                 185                 190         


Lys Gly Gly Glu Tyr Thr His Thr Phe Asn Arg Leu Asp Leu Gln Lys 
        195                 200                 205             


Glu Leu His Leu Leu Phe Glu Arg Gln Tyr Ala Leu Gly Asn Pro Phe 
    210                 215                 220                 


Ala Ser Ala Glu Leu Gln Ser Lys Val Asp Glu Leu Leu Met Thr Gln 
225                 230                 235                 240 


Arg Ser Ala Leu Gln Gly Glu Ala Val Leu Lys Met Leu Gly Lys Cys 
                245                 250                 255     


Thr Phe Glu Pro Ser Glu Tyr Lys Ala Ala Lys Asn Thr Tyr Ser Ala 
            260                 265                 270         


Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile Leu Tyr 
        275                 280                 285             


Asn Gly Glu Glu Arg Ala Leu Asp Glu Gly Asp Arg Lys Lys Leu Leu 
    290                 295                 300                 


Asp Glu Pro Tyr Lys Lys Ala Lys Leu Thr Tyr Lys Gln Val Arg Ser 
305                 310                 315                 320 


Ile Leu Asn Leu Pro Glu Ser Ala Val Phe Lys Gly Leu Arg Tyr Gly 
                325                 330                 335     


Lys Asp Ser Asp Gly Leu Lys Ala Glu Asn Gly Thr Leu Met Glu Met 
            340                 345                 350         


Lys Ala Tyr His Lys Ile Arg Thr Ile Leu Asp Lys Ala Gly Leu Lys 
        355                 360                 365             


Gly Glu Trp Glu Asn Arg Ile Arg Asn Pro Glu Ile Leu Asp Lys Ile 
    370                 375                 380                 


Gly Thr Ala Phe Ser Leu Tyr Lys Thr Asp Glu Asp Ile Gln Ala Ala 
385                 390                 395                 400 


Leu Ala Asp Leu Arg Leu Pro Glu Asn Val Leu Asp Ala Leu Leu Ala 
                405                 410                 415     


Gly Leu Asn Phe Asp Lys Phe Ile Gln Leu Ser Leu Lys Ala Leu Arg 
            420                 425                 430         


Asn Ile Leu Pro Leu Met Glu Arg Gly Ile Arg Tyr Asp Glu Ala Cys 
        435                 440                 445             


Lys Glu Val Tyr Gly Asp His Arg Ala Leu Ala Glu Ser Lys Asn Gln 
    450                 455                 460                 


Val Leu Leu Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val 
465                 470                 475                 480 


Leu Arg Thr Leu Thr Gln Ala Arg Lys Val Ile Asn Ala Ile Ile Arg 
                485                 490                 495     


Arg Tyr Gly Ser Pro Gln Arg Val His Ile Glu Thr Ala Arg Glu Leu 
            500                 505                 510         


Gly Lys Ser Lys Gln Glu Arg Asp Lys Ile Asp Arg Lys Asn Lys Glu 
        515                 520                 525             


Asn Gln Asn Asp Arg Asn Arg Leu Ala Ser Asp Ile Arg Lys His Phe 
    530                 535                 540                 


Asn Phe Glu Pro Thr Pro Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Asp Leu Arg Glu Glu Lys Gly 
                565                 570                 575     


Glu Cys Leu Tyr Thr Gly Asn Val Ile Glu Leu His Arg Leu Phe Glu 
            580                 585                 590         


Asp Gly Tyr Val Glu Ile Asp His Ala Leu Pro Leu Ser Arg Thr Trp 
        595                 600                 605             


Asp Asn Ser Leu Asn Asn Lys Val Leu Val Leu Lys Ser Ser Asn Gln 
    610                 615                 620                 


Asn Lys Gly Asn Lys Thr Pro Tyr Glu Trp Leu Asp Gly Ala Asn Asn 
625                 630                 635                 640 


Ser Arg Arg Trp Arg Glu Phe Gln Ala Arg Val Gln Gly Cys His Phe 
                645                 650                 655     


Pro Tyr Val Lys Lys Gln Arg Ile Gln Thr Ala Lys Leu Asp Ser Lys 
            660                 665                 670         


Ala Glu Gln Gly Phe Leu Glu Arg Asn Leu Asn Asp Thr Arg Tyr Ile 
        675                 680                 685             


Ser Lys Phe Met Cys Gln Phe Ile Thr Ala Asn Leu Arg Leu Ala Glu 
    690                 695                 700                 


Thr Ser Asn Ala Leu Met Glu Glu Val Ala Gly Glu Asn Pro Tyr Trp 
705                 710                 715                 720 


Lys Glu Arg Lys Arg Gln Arg Val Phe Ala Pro Ser Gly Ser Ile Ile 
                725                 730                 735     


Ala Leu Leu Arg Gly Leu Trp Gly Leu Lys Lys Val Arg Glu Asp Asn 
            740                 745                 750         


Asp Arg His His Ala Leu Asp Ala Ile Val Val Ala Cys Ser Thr Val 
        755                 760                 765             


Ser Met Gln Gln Lys Ile Thr Lys Ala Met Gln Arg Arg Glu Thr Leu 
    770                 775                 780                 


Glu Thr Val Asp Ser Glu Thr Gly Glu Val Lys Thr Arg Ile Pro Gln 
785                 790                 795                 800 


Pro Trp Asp Phe Phe Arg Gln Glu Val Met Ile Arg Val Phe Ser Asp 
                805                 810                 815     


Ser Pro Arg Glu Glu Leu Ala Glu Lys Leu Asn Ser Arg Pro Glu Ala 
            820                 825                 830         


Leu His Asp Phe Val Ser Pro Leu Phe Val Ser Arg Ala Pro Asn Arg 
        835                 840                 845             


Lys Met Thr Gly Gln Gly His Leu Glu Thr Val Lys Ser Ala Lys Arg 
    850                 855                 860                 


Leu Ser Glu Asn Ile Ser Val Val Arg Lys Pro Leu Thr Ala Leu Lys 
865                 870                 875                 880 


Leu Lys Asp Ile Glu Asn Ile Val Gly Tyr Pro Asp Arg Glu Pro Ala 
                885                 890                 895     


Leu Tyr Gln Ala Leu Arg Glu Arg Leu Leu Ala His Lys Asp Asp Pro 
            900                 905                 910         


Val Lys Ala Phe Ala Asp Lys Pro Phe Tyr Lys Pro Ala Lys Asp Gly 
        915                 920                 925             


Gly Gln Gly Ser Leu Val Lys Ala Val Arg Ile Ile Glu Asn Thr Lys 
    930                 935                 940                 


His Gly Leu Lys Ile Arg Asn Gly Ile Thr Asp Thr Asn Gly Asp Met 
945                 950                 955                 960 


Val Arg Thr Asp Val Tyr Gln Lys Thr Asp Lys Lys Gly Lys Arg Gln 
                965                 970                 975     


Tyr Phe Ile Val Pro Val Tyr Ala Trp Gln Val Glu Lys Asn Glu Leu 
            980                 985                 990         


Pro Thr Val Asp Cys Lys Gly Tyr  Glu Ile Asp Asp Asn  Tyr Glu Phe 
        995                 1000                 1005             


Cys Phe  Ser Leu Tyr Lys Tyr  Asp Leu Ile Glu Ile  Gln Asn Pro 
    1010                 1015                 1020             


Asn Asp  Ile Asn Gln Glu Leu  Arg Ala Tyr Tyr Ile  Asn Cys Asp 
    1025                 1030                 1035             


Ser Ser  Asp Gly Arg Phe Trp  Leu Ala Tyr His Asp  Lys Ser Ala 
    1040                 1045                 1050             


Lys Glu  Gln Gln Phe Arg Ile  Ser Thr Gln Asn Gln  Pro Ile Ile 
    1055                 1060                 1065             


Lys Lys  Tyr Gln Val Asp Thr  Leu Gly Lys Glu Ile  Arg Leu Cys 
    1070                 1075                 1080             


Lys Ala  Glu Lys Arg Thr Ala  Leu Asn Gly Lys Lys  Lys Lys 
    1085                 1090                 1095         


<210> 365
<211> 1426
<212> PRT
<213> Niabella soli


<220>
<223> Niabella soli DSM 19437

<400> 365
Met Pro Arg Lys Asn Ile Leu Gly Leu Asp Leu Gly Thr Thr Ser Ile 
1               5                   10                  15      


Gly Phe Ala Lys Ile Ile Glu Asp Asp Asp Tyr Gln Cys Ser Ser Val 
            20                  25                  30          


Glu Leu Ile Gly Val Arg Val Asn Pro Leu Thr Thr Asp Glu Gln Thr 
        35                  40                  45              


Asn Phe Glu Lys Gly Lys Pro Val Ser Val Asn Ala Asp Arg Thr Leu 
    50                  55                  60                  


Lys Arg Gly Met Arg Arg Asn Leu Asp Arg Tyr Gln Leu Arg Arg Asp 
65                  70                  75                  80  


Tyr Leu Ile Glu Ile Leu Arg Thr His His Ile Ile Thr Ala Asp Thr 
                85                  90                  95      


Lys Leu Ala Glu Asp Gly Lys Asn Thr Thr His Thr Thr Tyr Ala Leu 
            100                 105                 110         


Arg Ala Leu Ala Ala Thr Ala Glu Ile Pro Leu Glu Ala Phe Val Arg 
        115                 120                 125             


Val Leu Leu Ala Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys 
    130                 135                 140                 


Ala Lys Asn Glu Asp Glu Gly Gln Leu Ile Asp Gly Met Ala Ile Ala 
145                 150                 155                 160 


Arg Arg Leu Tyr Glu Glu Ser Leu Thr Pro Gly Gln Phe Ser Tyr Gln 
                165                 170                 175     


Leu Leu Lys Glu Gly Lys Lys Tyr Leu Pro Asp Phe Tyr Arg Ser Asp 
            180                 185                 190         


Leu Asn Thr Glu Leu Asn Lys Val Trp Asn Phe Gln Lys Gln Phe Tyr 
        195                 200                 205             


Pro Glu Ile Leu Thr Asp Glu Phe Lys Arg His Leu Glu Gly Lys Gly 
    210                 215                 220                 


Gln Arg Ala Thr Ala Val Ala Phe Trp Gly Gln His Gly Phe Ser Met 
225                 230                 235                 240 


Ala Glu Asn Lys Gly Ser Arg Glu Glu Lys Lys Leu His Ala Tyr Lys 
                245                 250                 255     


Trp Arg Ser Glu Ala Ala His Lys Gln Leu Thr Lys Glu Glu Val Ala 
            260                 265                 270         


Phe Val Ile Thr Glu Ile Asn Asn Asp Leu Asn Lys Ser Ser Gly Tyr 
        275                 280                 285             


Leu Gly Ala Ile Ser Asp Arg Ser Lys Glu Leu Phe Phe Asn Lys Gln 
    290                 295                 300                 


Thr Val Gly Gln Tyr Leu His Gln Gln Leu Lys Glu Asn Pro His Thr 
305                 310                 315                 320 


Arg Leu Lys Gly Gln Val Phe Tyr Arg Gln Asp Tyr Leu Asp Glu Phe 
                325                 330                 335     


Glu Thr Ile Trp Glu Met Gln Ala Lys Phe Tyr Ser Ala Leu Thr Leu 
            340                 345                 350         


Glu Leu Lys Glu Glu Val Arg Asp Val Val Ile Phe Tyr Gln Arg Lys 
        355                 360                 365             


Leu Lys Ser Gln Met Gly Leu Ile Ser Leu Cys Glu Phe Glu Ser Lys 
    370                 375                 380                 


Glu Ile Glu Ile Glu Lys Asn Gly Glu Lys Ala Lys Lys Arg Ile Gly 
385                 390                 395                 400 


Leu Arg Val Ala Pro Lys Ser Ser Pro Leu Phe Gln Glu Phe Lys Ile 
                405                 410                 415     


Trp Gln Val Leu Asn Asn Leu Glu Phe Arg Asn Lys Lys Thr Lys Glu 
            420                 425                 430         


Val Phe Val Pro Glu Met Ala Ala Lys Gln Gln Leu Phe Asp Glu Leu 
        435                 440                 445             


Asn Ile Lys Gly Asn Leu Leu Ala Ser Glu Ala Ile Lys Ile Leu Gly 
    450                 455                 460                 


Tyr Lys Thr Lys Asp Trp Glu Ala Asn Tyr His Thr Leu Glu Gly Asn 
465                 470                 475                 480 


Arg Thr Asn Lys Ser Leu Tyr Asp Ala Trp Leu Lys Ile Leu Glu Leu 
                485                 490                 495     


Glu Gly Tyr Asp Glu Asn Leu Leu Lys Leu Ser Gly Ser Asp Asp Ile 
            500                 505                 510         


Asp Val Ser Lys Ile Glu Lys Pro Ala Leu Glu Ile Arg Gln Met Val 
        515                 520                 525             


Leu Ala Val Phe Glu Val Leu Gly Ile Ser Gly Ala Ile Leu Asp Phe 
    530                 535                 540                 


Asp Ala Glu Ala Asp Gly Lys Ala Phe Glu Gln Gln Pro Ala Tyr Gln 
545                 550                 555                 560 


Leu Trp His Leu Leu Tyr Ser Ala Glu Asp Asp Gly Lys Lys Tyr Ser 
                565                 570                 575     


Gln Glu Asp Ile Phe Thr Tyr Gly His Asp Asn Ile Gly Leu Lys Lys 
            580                 585                 590         


Lys Leu Cys Glu Lys Phe Gly Phe Arg Pro Glu His Thr Lys Ile Leu 
        595                 600                 605             


Val Asn Val Val Phe Ser Asp Asp Tyr Gly Asn Leu Ser Ser Lys Ala 
    610                 615                 620                 


Met Arg Arg Ile Tyr Pro Phe Ile Lys Glu Leu Thr Tyr Asp Lys Ala 
625                 630                 635                 640 


Cys Ala Glu Ala Gly Tyr Arg His Ser Ala Ala Ser Leu Thr Lys Glu 
                645                 650                 655     


Glu Ile Ala Ala Arg Pro Leu Gln Asn Arg Leu Asp Leu Leu Lys Lys 
            660                 665                 670         


Asn Glu Leu Arg Ser Pro Val Val Glu Lys Ile Leu Asn Gln Met Val 
        675                 680                 685             


Asn Val Val Asn Thr Leu Val Asp Asp Glu Asn Gln Asn Arg Lys Ala 
    690                 695                 700                 


Arg Gly Leu Ser Glu Asp Phe His Phe Asp Glu Ile Arg Ile Glu Leu 
705                 710                 715                 720 


Ala Arg Glu Leu Lys Lys Asn Ala Lys Glu Arg Ala Glu Met Thr Thr 
                725                 730                 735     


Asn Ile Asn Thr Ala Lys Gln Ser His Glu Lys Ile Ile Arg Ile Leu 
            740                 745                 750         


Gln Thr Glu Phe Gly Val Pro Asn Pro Ser Arg Asn Asp Ile Val Arg 
        755                 760                 765             


Tyr Lys Leu Tyr Glu Glu Leu Lys Asn Asn Gly Tyr Lys Asp Leu Tyr 
    770                 775                 780                 


Thr Asn Thr Tyr Ile Ser Arg Asp Ile Leu Phe Ser Lys Gln Ile Asp 
785                 790                 795                 800 


Val Asp His Ile Ile Pro Gln Met Ser Leu Phe Asp Asp Ser Phe Ser 
                805                 810                 815     


Asn Lys Thr Val Val Phe Arg Lys Asp Asn Gln Asp Lys Gly Asn Lys 
            820                 825                 830         


Thr Ala Tyr Asp Tyr Ile Leu Gly Lys Tyr Gly Glu Gln Ala Leu Glu 
        835                 840                 845             


Glu Tyr Ile Ser Arg Ile Thr Ser Leu Phe Glu Leu Gly Lys Lys Asn 
    850                 855                 860                 


Lys Glu Glu Gly Ile Gly Lys Ala Lys Phe Gln Lys Leu Gln Lys Arg 
865                 870                 875                 880 


Leu Val Asp Ile Gly Asp Gly Phe Ile Glu Arg Asp Leu Arg Glu Ser 
                885                 890                 895     


Gln Tyr Ile Ala Lys Lys Ala Asn Asn Met Leu Tyr Ala Ile Cys Arg 
            900                 905                 910         


Ser Val Val Ser Thr Ser Gly Glu Ile Thr Ala Arg Leu Arg Glu Asp 
        915                 920                 925             


Trp Asp Leu Val Asn Val Met Gln Glu Ile Asn Leu Pro Lys Phe Arg 
    930                 935                 940                 


Ala Leu Gly Leu Thr Glu Met Val Glu Lys Lys Asp Gly Ala Gln Lys 
945                 950                 955                 960 


Glu Arg Ile Thr Asp Trp Thr Lys Arg Asn Asp His Arg His His Ala 
                965                 970                 975     


Met Asp Ala Leu Ala Ile Ala Phe Thr Arg His Ser His Ile Gln Tyr 
            980                 985                 990         


Leu Asn His Leu Asn Ala Arg Lys  Asp Glu Ala Asn Lys  Trp His Pro 
        995                 1000                 1005             


Val Val  Ser Lys Ile Glu Glu  Lys Glu Thr Val Leu  Ile Tyr Asp 
    1010                 1015                 1020             


Asp Leu  Gly Asn Arg Lys Arg  Lys Phe Lys Ala Pro  Met Pro Asn 
    1025                 1030                 1035             


Phe Arg  Glu Val Val Lys Glu  His Leu Glu Asn Val  Leu Ile Ser 
    1040                 1045                 1050             


His Lys  Ala Lys Asn Lys Val  Val Thr Lys Asn Lys  Asn Lys Ile 
    1055                 1060                 1065             


Lys Thr  Val Arg Gly Glu Lys  Val Lys Thr Glu Leu  Thr Pro Arg 
    1070                 1075                 1080             


Gly Gln  Leu His Lys Glu Thr  Ile Tyr Gly Arg Tyr  Arg Tyr Tyr 
    1085                 1090                 1095             


Glu Ser  Lys Glu Glu Lys Ile  Gly Pro Lys Phe Asp  Ala Glu Met 
    1100                 1105                 1110             


Ile Gly  Met Val Thr Asn Pro  Gln Tyr Lys Lys Leu  Leu Leu Glu 
    1115                 1120                 1125             


Arg Leu  Ala Ala Asn Gly Asn  Asp Pro Lys Lys Ala  Phe Trp Gly 
    1130                 1135                 1140             


Lys Asn  Ala Leu Asn Lys Asn  Pro Leu Tyr Val Asp  Glu Ala Arg 
    1145                 1150                 1155             


Gln Glu  Leu Leu Pro Glu Lys  Ile Leu Leu Arg Trp  Leu Asn Asp 
    1160                 1165                 1170             


Asp Tyr  Ser Ile Arg Lys Asp  Val Thr Pro Glu Asn  Leu Lys Asp 
    1175                 1180                 1185             


Ile Lys  Thr Ile Glu Lys Ile  Leu Asp Lys Gly Val  Lys Lys Ile 
    1190                 1195                 1200             


Leu Leu  Lys Arg Leu Ala Asp  Phe Gly Asn Asp Pro  Lys Lys Ala 
    1205                 1210                 1215             


Phe Ser  Asp Leu Asp Lys Asn  Pro Ile Trp Gln Asn  Glu Ala Lys 
    1220                 1225                 1230             


Arg Ile  Ala Ile Lys Arg Val  Thr Ile Ser Gly Ile  Lys Asn Ala 
    1235                 1240                 1245             


Ala Pro  Leu His His Lys Lys  Asp His Leu Gly Asn  Asp Ile Leu 
    1250                 1255                 1260             


Asp Glu  Lys Gly Lys Gln Ile  Pro Ser Ser Phe Val  Ser Thr Gly 
    1265                 1270                 1275             


Asn Asn  His His Val Ala Ile  Tyr Arg Asp Ala Glu  Gly Asn Leu 
    1280                 1285                 1290             


Gln Glu  Arg Val Val Ser Leu  Phe Asp Ala Val Gln  Leu Val Asn 
    1295                 1300                 1305             


Gly Gly  Glu Pro Val Ile Asp  Lys Glu Tyr Asn Lys  Gly Ile Gly 
    1310                 1315                 1320             


Trp Gln  Phe Leu Phe Thr Met  Lys Gln Asn Glu Met  Phe Val Phe 
    1325                 1330                 1335             


Pro Asp  Glu Lys Thr Gly Phe  Asn Pro Arg Glu Val  Asp Leu Leu 
    1340                 1345                 1350             


Ser Ser  Gly Asn Arg Lys Leu  Ile Ser Pro Asn Leu  Phe Arg Val 
    1355                 1360                 1365             


Gln Lys  Leu Ala Ser Lys Asn  Tyr Phe Phe Arg His  His Leu Glu 
    1370                 1375                 1380             


Thr Ser  Val Glu Glu Lys Lys  Glu Leu Lys Asn Ile  Ala Tyr Lys 
    1385                 1390                 1395             


Pro Gln  Leu Gly Leu Asn Ala  Leu Ser Asn Ile Val  Lys Val Arg 
    1400                 1405                 1410             


Ile Asn  His Ile Gly Glu Ile  Val Ser Val Gly Glu  Tyr 
    1415                 1420                 1425     


<210> 366
<211> 1132
<212> PRT
<213> Nitratifractor salsuginis

<400> 366
Met Lys Lys Ile Leu Gly Val Asp Leu Gly Ile Thr Ser Phe Gly Tyr 
1               5                   10                  15      


Ala Ile Leu Gln Glu Thr Gly Lys Asp Leu Tyr Arg Cys Leu Asp Asn 
            20                  25                  30          


Ser Val Val Met Arg Asn Asn Pro Tyr Asp Glu Lys Ser Gly Glu Ser 
        35                  40                  45              


Ser Gln Ser Ile Arg Ser Thr Gln Lys Ser Met Arg Arg Leu Ile Glu 
    50                  55                  60                  


Lys Arg Lys Lys Arg Ile Arg Cys Val Ala Gln Thr Met Glu Arg Tyr 
65                  70                  75                  80  


Gly Ile Leu Asp Tyr Ser Glu Thr Met Lys Ile Asn Asp Pro Lys Asn 
                85                  90                  95      


Asn Pro Ile Lys Asn Arg Trp Gln Leu Arg Ala Val Asp Ala Trp Lys 
            100                 105                 110         


Arg Pro Leu Ser Pro Gln Glu Leu Phe Ala Ile Phe Ala His Met Ala 
        115                 120                 125             


Lys His Arg Gly Tyr Lys Ser Ile Ala Thr Glu Asp Leu Ile Tyr Glu 
    130                 135                 140                 


Leu Glu Leu Glu Leu Gly Leu Asn Asp Pro Glu Lys Glu Ser Glu Lys 
145                 150                 155                 160 


Lys Ala Asp Glu Arg Arg Gln Val Tyr Asn Ala Leu Arg His Leu Glu 
                165                 170                 175     


Glu Leu Arg Lys Lys Tyr Gly Gly Glu Thr Ile Ala Gln Thr Ile His 
            180                 185                 190         


Arg Ala Val Glu Ala Gly Asp Leu Arg Ser Tyr Arg Asn His Asp Asp 
        195                 200                 205             


Tyr Glu Lys Met Ile Arg Arg Glu Asp Ile Glu Glu Glu Ile Glu Lys 
    210                 215                 220                 


Val Leu Leu Arg Gln Ala Glu Leu Gly Ala Leu Gly Leu Pro Glu Glu 
225                 230                 235                 240 


Gln Val Ser Glu Leu Ile Asp Glu Leu Lys Ala Cys Ile Thr Asp Gln 
                245                 250                 255     


Glu Met Pro Thr Ile Asp Glu Ser Leu Phe Gly Lys Cys Thr Phe Tyr 
            260                 265                 270         


Lys Asp Glu Leu Ala Ala Pro Ala Tyr Ser Tyr Leu Tyr Asp Leu Tyr 
        275                 280                 285             


Arg Leu Tyr Lys Lys Leu Ala Asp Leu Asn Ile Asp Gly Tyr Glu Val 
    290                 295                 300                 


Thr Gln Glu Asp Arg Glu Lys Val Ile Glu Trp Val Glu Lys Lys Ile 
305                 310                 315                 320 


Ala Gln Gly Lys Asn Leu Lys Lys Ile Thr His Lys Asp Leu Arg Lys 
                325                 330                 335     


Ile Leu Gly Leu Ala Pro Glu Gln Lys Ile Phe Gly Val Glu Asp Glu 
            340                 345                 350         


Arg Ile Val Lys Gly Lys Lys Glu Pro Arg Thr Phe Val Pro Phe Phe 
        355                 360                 365             


Phe Leu Ala Asp Ile Ala Lys Phe Lys Glu Leu Phe Ala Ser Ile Gln 
    370                 375                 380                 


Lys His Pro Asp Ala Leu Gln Ile Phe Arg Glu Leu Ala Glu Ile Leu 
385                 390                 395                 400 


Gln Arg Ser Lys Thr Pro Gln Glu Ala Leu Asp Arg Leu Arg Ala Leu 
                405                 410                 415     


Met Ala Gly Lys Gly Ile Asp Thr Asp Asp Arg Glu Leu Leu Glu Leu 
            420                 425                 430         


Phe Lys Asn Lys Arg Ser Gly Thr Arg Glu Leu Ser His Arg Tyr Ile 
        435                 440                 445             


Leu Glu Ala Leu Pro Leu Phe Leu Glu Gly Tyr Asp Glu Lys Glu Val 
    450                 455                 460                 


Gln Arg Ile Leu Gly Phe Asp Asp Arg Glu Asp Tyr Ser Arg Tyr Pro 
465                 470                 475                 480 


Lys Ser Leu Arg His Leu His Leu Arg Glu Gly Asn Leu Phe Glu Lys 
                485                 490                 495     


Glu Glu Asn Pro Ile Asn Asn His Ala Val Lys Ser Leu Ala Ser Trp 
            500                 505                 510         


Ala Leu Gly Leu Ile Ala Asp Leu Ser Trp Arg Tyr Gly Pro Phe Asp 
        515                 520                 525             


Glu Ile Ile Leu Glu Thr Thr Arg Asp Ala Leu Pro Glu Lys Ile Arg 
    530                 535                 540                 


Lys Glu Ile Asp Lys Ala Met Arg Glu Arg Glu Lys Ala Leu Asp Lys 
545                 550                 555                 560 


Ile Ile Gly Lys Tyr Lys Lys Glu Phe Pro Ser Ile Asp Lys Arg Leu 
                565                 570                 575     


Ala Arg Lys Ile Gln Leu Trp Glu Arg Gln Lys Gly Leu Asp Leu Tyr 
            580                 585                 590         


Ser Gly Lys Val Ile Asn Leu Ser Gln Leu Leu Asp Gly Ser Ala Asp 
        595                 600                 605             


Ile Glu His Ile Val Pro Gln Ser Leu Gly Gly Leu Ser Thr Asp Tyr 
    610                 615                 620                 


Asn Thr Ile Val Thr Leu Lys Ser Val Asn Ala Ala Lys Gly Asn Arg 
625                 630                 635                 640 


Leu Pro Gly Asp Trp Leu Ala Gly Asn Pro Asp Tyr Arg Glu Arg Ile 
                645                 650                 655     


Gly Met Leu Ser Glu Lys Gly Leu Ile Asp Trp Lys Lys Arg Lys Asn 
            660                 665                 670         


Leu Leu Ala Gln Ser Leu Asp Glu Ile Tyr Thr Glu Asn Thr His Ser 
        675                 680                 685             


Lys Gly Ile Arg Ala Thr Ser Tyr Leu Glu Ala Leu Val Ala Gln Val 
    690                 695                 700                 


Leu Lys Arg Tyr Tyr Pro Phe Pro Asp Pro Glu Leu Arg Lys Asn Gly 
705                 710                 715                 720 


Ile Gly Val Arg Met Ile Pro Gly Lys Val Thr Ser Lys Thr Arg Ser 
                725                 730                 735     


Leu Leu Gly Ile Lys Ser Lys Ser Arg Glu Thr Asn Phe His His Ala 
            740                 745                 750         


Glu Asp Ala Leu Ile Leu Ser Thr Leu Thr Arg Gly Trp Gln Asn Arg 
        755                 760                 765             


Leu His Arg Met Leu Arg Asp Asn Tyr Gly Lys Ser Glu Ala Glu Leu 
    770                 775                 780                 


Lys Glu Leu Trp Lys Lys Tyr Met Pro His Ile Glu Gly Leu Thr Leu 
785                 790                 795                 800 


Ala Asp Tyr Ile Asp Glu Ala Phe Arg Arg Phe Met Ser Lys Gly Glu 
                805                 810                 815     


Glu Ser Leu Phe Tyr Arg Asp Met Phe Asp Thr Ile Arg Ser Ile Ser 
            820                 825                 830         


Tyr Trp Val Asp Lys Lys Pro Leu Ser Ala Ser Ser His Lys Glu Thr 
        835                 840                 845             


Val Tyr Ser Ser Arg His Glu Val Pro Thr Leu Arg Lys Asn Ile Leu 
    850                 855                 860                 


Glu Ala Phe Asp Ser Leu Asn Val Ile Lys Asp Arg His Lys Leu Thr 
865                 870                 875                 880 


Thr Glu Glu Phe Met Lys Arg Tyr Asp Lys Glu Ile Arg Gln Lys Leu 
                885                 890                 895     


Trp Leu His Arg Ile Gly Asn Thr Asn Asp Glu Ser Tyr Arg Ala Val 
            900                 905                 910         


Glu Glu Arg Ala Thr Gln Ile Ala Gln Ile Leu Thr Arg Tyr Gln Leu 
        915                 920                 925             


Met Asp Ala Gln Asn Asp Lys Glu Ile Asp Glu Lys Phe Gln Gln Ala 
    930                 935                 940                 


Leu Lys Glu Leu Ile Thr Ser Pro Ile Glu Val Thr Gly Lys Leu Leu 
945                 950                 955                 960 


Arg Lys Met Arg Phe Val Tyr Asp Lys Leu Asn Ala Met Gln Ile Asp 
                965                 970                 975     


Arg Gly Leu Val Glu Thr Asp Lys Asn Met Leu Gly Ile His Ile Ser 
            980                 985                 990         


Lys Gly Pro Asn Glu Lys Leu Ile  Phe Arg Arg Met Asp  Val Asn Asn 
        995                 1000                 1005             


Ala His  Glu Leu Gln Lys Glu  Arg Ser Gly Ile Leu  Cys Tyr Leu 
    1010                 1015                 1020             


Asn Glu  Met Leu Phe Ile Phe  Asn Lys Lys Gly Leu  Ile His Tyr 
    1025                 1030                 1035             


Gly Cys  Leu Arg Ser Tyr Leu  Glu Lys Gly Gln Gly  Ser Lys Tyr 
    1040                 1045                 1050             


Ile Ala  Leu Phe Asn Pro Arg  Phe Pro Ala Asn Pro  Lys Ala Gln 
    1055                 1060                 1065             


Pro Ser  Lys Phe Thr Ser Asp  Ser Lys Ile Lys Gln  Val Gly Ile 
    1070                 1075                 1080             


Gly Ser  Ala Thr Gly Ile Ile  Lys Ala His Leu Asp  Leu Asp Gly 
    1085                 1090                 1095             


His Val  Arg Ser Tyr Glu Val  Phe Gly Thr Leu Pro  Glu Gly Ser 
    1100                 1105                 1110             


Ile Glu  Trp Phe Lys Glu Glu  Ser Gly Tyr Gly Arg  Val Glu Asp 
    1115                 1120                 1125             


Asp Pro  His His 
    1130         


<210> 367
<211> 1166
<212> PRT
<213> Nitrobacter hamburgensis

<400> 367
Met His Val Glu Ile Asp Phe Pro His Phe Ser Arg Gly Asp Ser His 
1               5                   10                  15      


Leu Ala Met Asn Lys Asn Glu Ile Leu Arg Gly Ser Ser Val Leu Tyr 
            20                  25                  30          


Arg Leu Gly Leu Asp Leu Gly Ser Asn Ser Leu Gly Trp Phe Val Thr 
        35                  40                  45              


His Leu Glu Lys Arg Gly Asp Arg His Glu Pro Val Ala Leu Gly Pro 
    50                  55                  60                  


Gly Gly Val Arg Ile Phe Pro Asp Gly Arg Asp Pro Gln Ser Gly Thr 
65                  70                  75                  80  


Ser Asn Ala Val Asp Arg Arg Met Ala Arg Gly Ala Arg Lys Arg Arg 
                85                  90                  95      


Asp Arg Phe Val Glu Arg Arg Lys Glu Leu Ile Ala Ala Leu Ile Lys 
            100                 105                 110         


Tyr Asn Leu Leu Pro Asp Asp Ala Arg Glu Arg Arg Ala Leu Glu Val 
        115                 120                 125             


Leu Asp Pro Tyr Ala Leu Arg Lys Thr Ala Leu Thr Asp Thr Leu Pro 
    130                 135                 140                 


Ala His His Val Gly Arg Ala Leu Phe His Leu Asn Gln Arg Arg Gly 
145                 150                 155                 160 


Phe Gln Ser Asn Arg Lys Thr Asp Ser Lys Gln Ser Glu Asp Gly Ala 
                165                 170                 175     


Ile Lys Gln Ala Ala Ser Arg Leu Ala Thr Asp Lys Gly Asn Glu Thr 
            180                 185                 190         


Leu Gly Val Phe Phe Ala Asp Met His Leu Arg Lys Ser Tyr Glu Asp 
        195                 200                 205             


Arg Gln Thr Ala Ile Arg Ala Glu Leu Val Arg Leu Gly Lys Asp His 
    210                 215                 220                 


Leu Thr Gly Asn Ala Arg Lys Lys Ile Trp Ala Lys Val Arg Lys Arg 
225                 230                 235                 240 


Leu Phe Gly Asp Glu Val Leu Pro Arg Ala Asp Ala Pro His Gly Val 
                245                 250                 255     


Arg Ala Arg Ala Thr Ile Thr Gly Thr Lys Ala Ser Tyr Asp Tyr Tyr 
            260                 265                 270         


Pro Thr Arg Asp Met Leu Arg Asp Glu Phe Asn Ala Ile Trp Ala Gly 
        275                 280                 285             


Gln Ser Ala His His Ala Thr Ile Thr Asp Glu Ala Arg Thr Glu Ile 
    290                 295                 300                 


Glu His Ile Ile Phe Tyr Gln Arg Pro Leu Lys Pro Ala Ile Val Gly 
305                 310                 315                 320 


Lys Cys Thr Leu Asp Pro Ala Thr Arg Pro Phe Lys Glu Asp Pro Glu 
                325                 330                 335     


Gly Tyr Arg Ala Pro Trp Ser His Pro Leu Ala Gln Arg Phe Arg Ile 
            340                 345                 350         


Leu Ser Glu Ala Arg Asn Leu Glu Ile Arg Asp Thr Gly Lys Gly Ser 
        355                 360                 365             


Arg Arg Leu Thr Lys Glu Gln Ser Asp Leu Val Val Ala Ala Leu Leu 
    370                 375                 380                 


Ala Asn Arg Glu Val Lys Phe Asp Lys Leu Arg Thr Leu Leu Lys Leu 
385                 390                 395                 400 


Pro Ala Glu Ala Arg Phe Asn Leu Glu Ser Asp Arg Arg Ala Ala Leu 
                405                 410                 415     


Asp Gly Asp Gln Thr Ala Ala Arg Leu Ser Asp Lys Lys Gly Phe Asn 
            420                 425                 430         


Lys Ala Trp Arg Gly Phe Pro Pro Glu Arg Gln Ile Ala Ile Val Ala 
        435                 440                 445             


Arg Leu Glu Glu Thr Glu Asp Glu Asn Glu Leu Ile Ala Trp Leu Glu 
    450                 455                 460                 


Lys Glu Cys Ala Leu Asp Gly Ala Ala Ala Ala Arg Val Ala Asn Thr 
465                 470                 475                 480 


Thr Leu Pro Asp Gly His Cys Arg Leu Gly Leu Arg Ala Ile Lys Lys 
                485                 490                 495     


Ile Val Pro Ile Met Gln Asp Gly Leu Asp Glu Asp Gly Val Ala Gly 
            500                 505                 510         


Ala Gly Tyr His Ile Ala Ala Lys Arg Ala Gly Tyr Asp His Ala Lys 
        515                 520                 525             


Leu Pro Thr Gly Glu Gln Leu Gly Arg Leu Pro Tyr Tyr Gly Gln Trp 
    530                 535                 540                 


Leu Gln Asp Ala Val Val Gly Ser Gly Asp Ala Arg Asp Gln Lys Glu 
545                 550                 555                 560 


Lys Gln Tyr Gly Gln Phe Pro Asn Pro Thr Val His Ile Gly Leu Gly 
                565                 570                 575     


Gln Leu Arg Arg Val Val Asn Asp Leu Ile Asp Lys Tyr Gly Pro Pro 
            580                 585                 590         


Thr Glu Ile Ser Ile Glu Phe Thr Arg Ala Leu Lys Leu Ser Glu Gln 
        595                 600                 605             


Gln Lys Ala Glu Arg Gln Arg Glu Gln Arg Arg Asn Gln Asp Lys Asn 
    610                 615                 620                 


Lys Ala Arg Ala Glu Glu Leu Ala Lys Phe Gly Arg Pro Ala Asn Pro 
625                 630                 635                 640 


Arg Asn Leu Leu Lys Met Arg Leu Trp Glu Glu Leu Ala His Asp Pro 
                645                 650                 655     


Leu Asp Arg Lys Cys Val Tyr Thr Gly Glu Gln Ile Ser Ile Glu Arg 
            660                 665                 670         


Leu Leu Ser Asp Glu Val Asp Ile Asp His Ile Leu Pro Val Ala Met 
        675                 680                 685             


Thr Leu Asp Asp Ser Pro Ala Asn Lys Ile Ile Cys Met Arg Tyr Ala 
    690                 695                 700                 


Asn Arg His Lys Arg Lys Gln Thr Pro Ser Glu Ala Phe Gly Ser Ser 
705                 710                 715                 720 


Pro Thr Leu Gln Gly His Arg Tyr Asn Trp Asp Asp Ile Ala Ala Arg 
                725                 730                 735     


Ala Thr Gly Leu Pro Arg Asn Lys Arg Trp Arg Phe Asp Ala Asn Ala 
            740                 745                 750         


Arg Glu Glu Phe Asp Lys Arg Gly Gly Phe Leu Ala Arg Gln Leu Asn 
        755                 760                 765             


Glu Thr Gly Trp Leu Ala Arg Leu Ala Lys Gln Tyr Leu Gly Ala Val 
    770                 775                 780                 


Thr Asp Pro Asn Gln Ile Trp Val Val Pro Gly Arg Leu Thr Ser Met 
785                 790                 795                 800 


Leu Arg Gly Lys Trp Gly Leu Asn Gly Leu Leu Pro Ser Asp Asn Tyr 
                805                 810                 815     


Ala Gly Val Gln Asp Lys Ala Glu Glu Phe Leu Ala Ser Thr Asp Asp 
            820                 825                 830         


Met Glu Phe Ser Gly Val Lys Asn Arg Ala Asp His Arg His His Ala 
        835                 840                 845             


Ile Asp Gly Leu Val Thr Ala Leu Thr Asp Arg Ser Leu Leu Trp Lys 
    850                 855                 860                 


Met Ala Asn Ala Tyr Asp Glu Glu His Glu Lys Phe Val Ile Glu Pro 
865                 870                 875                 880 


Pro Trp Pro Thr Met Arg Asp Asp Leu Lys Ala Ala Leu Glu Lys Met 
                885                 890                 895     


Val Val Ser His Lys Pro Asp His Gly Ile Glu Gly Lys Leu His Glu 
            900                 905                 910         


Asp Ser Ala Tyr Gly Phe Val Lys Pro Leu Asp Ala Thr Gly Leu Lys 
        915                 920                 925             


Glu Glu Glu Ala Gly Asn Leu Val Tyr Arg Lys Ala Ile Glu Ser Leu 
    930                 935                 940                 


Asn Glu Asn Glu Val Asp Arg Ile Arg Asp Ile Gln Leu Arg Thr Ile 
945                 950                 955                 960 


Val Arg Asp His Val Asn Val Glu Lys Thr Lys Gly Val Ala Leu Ala 
                965                 970                 975     


Asp Ala Leu Arg Gln Leu Gln Ala Pro Ser Asp Asp Tyr Pro Gln Phe 
            980                 985                 990         


Lys His Gly Leu Arg His Val Arg  Ile Leu Lys Lys Glu  Lys Gly Asp 
        995                 1000                 1005             


Tyr Leu  Val Pro Ile Ala Asn  Arg Ala Ser Gly Val  Ala Tyr Lys 
    1010                 1015                 1020             


Ala Tyr  Ser Ala Gly Glu Asn  Phe Cys Val Glu Val  Phe Glu Thr 
    1025                 1030                 1035             


Ala Gly  Gly Lys Trp Asp Gly  Glu Ala Val Arg Arg  Phe Asp Ala 
    1040                 1045                 1050             


Asn Lys  Lys Asn Ala Gly Pro  Lys Ile Ala His Ala  Pro Gln Trp 
    1055                 1060                 1065             


Arg Asp  Ala Asn Glu Gly Ala  Lys Leu Val Met Arg  Ile His Lys 
    1070                 1075                 1080             


Gly Asp  Leu Ile Arg Leu Asp  His Glu Gly Arg Ala  Arg Ile Met 
    1085                 1090                 1095             


Val Val  His Arg Leu Asp Ala  Ala Ala Gly Arg Phe  Lys Leu Ala 
    1100                 1105                 1110             


Asp His  Asn Glu Thr Gly Asn  Leu Asp Lys Arg His  Ala Thr Asn 
    1115                 1120                 1125             


Asn Asp  Ile Asp Pro Phe Arg  Trp Leu Met Ala Ser  Tyr Asn Thr 
    1130                 1135                 1140             


Leu Lys  Lys Leu Ala Ala Val  Pro Val Arg Val Asp  Glu Leu Gly 
    1145                 1150                 1155             


Arg Val  Trp Arg Val Met Pro  Asn 
    1160                 1165     


<210> 368
<211> 1044
<212> PRT
<213> Nitrosomonas sp.


<220>
<223> Nitrosomonas sp. AL212

<400> 368
Met Leu His Lys Met Arg Tyr Arg Leu Ala Leu Asp Leu Gly Ser Thr 
1               5                   10                  15      


Ser Leu Gly Trp Ala Met Val Arg Leu Asn Ala Asn Gln Gln Pro Cys 
            20                  25                  30          


Ala Val Ile Lys Ala Gly Val Arg Ile Phe Ser Asn Gly Arg Asn Pro 
        35                  40                  45              


Lys Asp Gly Ser Ser Leu Ala Val Thr Arg Arg Glu Ala Arg Ser Met 
    50                  55                  60                  


Arg Arg Arg Arg Asp Arg Leu Leu Lys Arg Lys Ala Arg Met Met Arg 
65                  70                  75                  80  


Thr Leu Ile Glu Tyr Gly Phe Phe Pro Ala Asn Glu Thr Gln Arg Lys 
                85                  90                  95      


Ala Leu Glu Asn Leu Asn Pro Tyr Ala Leu Arg Ala Lys Gly Leu Asp 
            100                 105                 110         


Glu Ala Leu Thr Pro Ser Glu Phe Ala Arg Ala Leu Phe His Ile Asn 
        115                 120                 125             


Gln Arg Arg Gly Phe Lys Ser Asn Arg Lys Thr Asp Lys Lys Asp Ser 
    130                 135                 140                 


Asp Ser Gly Ala Leu Lys Thr Ala Ile Lys Gln Leu His Ser Val Leu 
145                 150                 155                 160 


Asp Pro Gln Gly Asn Asp Gly Lys Pro Arg Thr Val Gly Glu Leu Leu 
                165                 170                 175     


Tyr Lys Arg Phe Thr Asp Leu Ser Lys Leu Pro Lys Asp Arg Thr Val 
            180                 185                 190         


Arg Ala Arg Tyr Arg Gln Asp Lys Ile Val Lys Asp Asp Gly Lys Thr 
        195                 200                 205             


Lys Ile Asp Lys Tyr Tyr Asp Leu Tyr Ile Asp Arg Ala Met Ile Glu 
    210                 215                 220                 


Gln Glu Phe Asp Ala Leu Trp Lys Lys Gln Ser Glu Leu Asn Pro Ile 
225                 230                 235                 240 


Leu Phe Thr Glu Asn Ala Arg Ala Asp Leu Lys Asp Val Leu Leu Tyr 
                245                 250                 255     


Gln Arg Ser Leu Lys Pro Val Lys Pro Gly Arg Cys Thr Phe Met Ser 
            260                 265                 270         


Glu Glu Glu Arg Ala Pro Leu Ala Leu Pro Ser Thr Gln Arg Phe Arg 
        275                 280                 285             


Met Tyr Gln Glu Val Asn Asn Leu Arg Ile Leu Arg Glu Gly Leu Lys 
    290                 295                 300                 


Glu Glu Ser Leu Thr Leu Gln Gln Arg Asp Asp Leu Ile Asn Ala Leu 
305                 310                 315                 320 


Glu Lys Asn Asn Arg Arg Thr Phe Thr Gln Ile Lys Lys Leu Leu Gly 
                325                 330                 335     


Val Gly Gly Ser Val Gln Phe Asn Phe Glu Asp Pro Lys Arg Glu Glu 
            340                 345                 350         


Leu Lys Gly Asn Thr Thr Ser Ala Ile Leu Gly Lys Ser Glu His Phe 
        355                 360                 365             


Gly Glu Ala Trp Phe Ala Phe Asn Glu Ala Lys Gln Asp Ala Ile Val 
    370                 375                 380                 


Leu Gln Leu Ile Lys Glu Glu Asn Glu Ala Lys Leu Val Arg Trp Leu 
385                 390                 395                 400 


Gln Asp Glu Thr Gly Ile Asp Glu Lys Arg Ala Glu Val Ile Ala Asn 
                405                 410                 415     


Ala Gly Leu Pro Glu Gly Tyr Gly Ser Leu Cys Ile Glu Ala Leu Ala 
            420                 425                 430         


Arg Ile Leu Pro Glu Leu Arg Arg Asp Val Val Thr Tyr Asp Lys Ala 
        435                 440                 445             


Val Gln Ala Ala Gly Phe Glu His His Ser Lys Leu Asn Arg Asn Glu 
    450                 455                 460                 


Glu Ile Pro Asp Ile Thr Phe Lys Ile Glu Ser Ile Asp Arg Asn Ser 
465                 470                 475                 480 


Gly Glu Ile Lys Gln Phe His Leu His Lys Glu Leu Pro Tyr Tyr Gly 
                485                 490                 495     


Glu Tyr Leu Gln Arg His Val Gly Phe Gly Ser Gly Lys Pro Glu Asp 
            500                 505                 510         


Ser Ile Glu Lys Arg Tyr Gly Lys Ile Ala Asn Pro Thr Val His Ile 
        515                 520                 525             


Gly Leu Asn Gln Val Arg Val Val Val Asn Ala Leu Ile Lys Arg Tyr 
    530                 535                 540                 


Gly His Pro Ser Glu Ile Ile Val Glu Val Ala Arg Asp Leu Lys Gln 
545                 550                 555                 560 


Ser Lys Asp Arg Arg Asp Glu Glu Asn Lys Arg Gln Ala Glu Asn Gln 
                565                 570                 575     


Lys Arg Asn Glu Arg Leu Arg Lys Asp Ile Ala Asp Ile Leu Gly Ile 
            580                 585                 590         


Ser Glu Glu Arg Val Arg Arg Asp Asp Ile Glu Lys Met Ile Leu Trp 
        595                 600                 605             


Glu Glu Leu Ser Phe Asp Pro Ala Asp Arg Arg Cys Pro Tyr Ser Gly 
    610                 615                 620                 


Val Gln Val Ser Thr Val Met Leu Leu Ser Asp Glu Val Glu Val Glu 
625                 630                 635                 640 


His Ile Leu Pro Phe Ser Gln Thr Leu Asp Asp Ser Leu Asn Asn Lys 
                645                 650                 655     


Thr Val Ala Leu Arg Gln Ala Asn Arg Ile Lys Gly Asn Arg Thr Pro 
            660                 665                 670         


Trp Glu Ala Phe Gly Thr Ser Asn Ile Ser Gly Phe Asp Tyr Ser Gly 
        675                 680                 685             


Ile Leu Thr Arg Ala Glu Leu Met Pro Lys Ala Lys Arg Tyr Arg Phe 
    690                 695                 700                 


Ala Glu Asp Gly Tyr Gln Arg Trp Leu Lys Asp Asp Ala Gly Phe Leu 
705                 710                 715                 720 


Ala Arg Ala Leu Asn Asp Thr Arg His Leu Ser Lys Ile Ala Arg Glu 
                725                 730                 735     


Tyr Met Ser Leu Ile Cys Pro Asn Thr Arg Val Ile Pro Gly Gln Met 
            740                 745                 750         


Thr Ala Met Leu Arg Arg Asn Phe Gly Leu Asn Asp Val Leu Gly Leu 
        755                 760                 765             


Asn Gly Glu Lys Asn Arg Asn Asp His Arg His His Ala Val Asp Ala 
    770                 775                 780                 


Cys Val Ile Ala Val Thr Asp Gln Gly Leu Leu Gln Arg Phe Ala Ala 
785                 790                 795                 800 


Ala Ser Ala Ser Ala Arg Glu Arg Gln Leu Asn Arg Leu Val Glu Asn 
                805                 810                 815     


Met Pro Leu Pro Trp Glu Ser Tyr Arg Glu His Val Arg Arg Ala Ile 
            820                 825                 830         


Asp Gly Ile Trp Val Ser His Arg Pro Asp His Ser His Glu Gly Ala 
        835                 840                 845             


Met His Asn Asp Thr Ala Tyr Gly Leu Arg Gly Asn Gly Arg Val Ser 
    850                 855                 860                 


Phe His Lys Met Val Glu Gly Lys Arg Glu Tyr Ile Glu Asp Asn Leu 
865                 870                 875                 880 


Lys Val Ile Glu Ile Thr Asp Thr Lys Ala Ile Asp Arg His Gly Leu 
                885                 890                 895     


Leu Pro Thr Gly Lys Pro Arg Pro Tyr Lys Gly Tyr Lys Gly Asp Ser 
            900                 905                 910         


Asn Tyr Cys Ile Glu Ile Val Arg Asn Glu Lys Gly Arg Trp Glu Gly 
        915                 920                 925             


Glu Ile Ile Ser Thr Phe Asp Ala Tyr Gln Leu Val Arg Lys Tyr Gly 
    930                 935                 940                 


Ile Val Gln Leu Arg Tyr Pro Val Leu Ser Val Ser Gly Lys Pro Leu 
945                 950                 955                 960 


Val Met Arg Leu Ile Arg Asn Asp Phe Val Arg Leu Glu His Glu Gly 
                965                 970                 975     


Ile Thr Arg Thr Leu Arg Val Cys Lys Met Arg Glu Asp Gly Gln Val 
            980                 985                 990         


Ala Leu Ala Asp Val Thr Glu Ala  Asn Val Asp Ala Arg  Thr Arg Thr 
        995                 1000                 1005             


Lys Glu  Ile Cys Tyr Val Phe  Lys Thr Gly Gly Ser  Leu Gln Lys 
    1010                 1015                 1020             


Ala Lys  Ala Arg Arg Ile Thr  Ile Ser Pro Ile Gly  Glu Leu Arg 
    1025                 1030                 1035             


Asp Pro  Gly Phe Lys Glu 
    1040                 


<210> 369
<211> 1498
<212> PRT
<213> Odoribacter laneus


<220>
<223> Odoribacter laneus YIT 12061

<400> 369
Met Glu Thr Thr Leu Gly Ile Asp Leu Gly Thr Asn Ser Ile Gly Leu 
1               5                   10                  15      


Ala Leu Val Asp Gln Glu Glu His Gln Ile Leu Tyr Ser Gly Val Arg 
            20                  25                  30          


Ile Phe Pro Glu Gly Ile Asn Lys Asp Thr Ile Gly Leu Gly Glu Lys 
        35                  40                  45              


Glu Glu Ser Arg Asn Ala Thr Arg Arg Ala Lys Arg Gln Met Arg Arg 
    50                  55                  60                  


Gln Tyr Phe Arg Lys Lys Leu Arg Lys Ala Lys Leu Leu Glu Leu Leu 
65                  70                  75                  80  


Ile Ala Tyr Asp Met Cys Pro Leu Lys Pro Glu Asp Val Arg Arg Trp 
                85                  90                  95      


Lys Asn Trp Asp Lys Gln Gln Lys Ser Thr Val Arg Gln Phe Pro Asp 
            100                 105                 110         


Thr Pro Ala Phe Arg Glu Trp Leu Lys Gln Asn Pro Tyr Glu Leu Arg 
        115                 120                 125             


Lys Gln Ala Val Thr Glu Asp Val Thr Arg Pro Glu Leu Gly Arg Ile 
    130                 135                 140                 


Leu Tyr Gln Met Ile Gln Arg Arg Gly Phe Leu Ser Ser Arg Lys Gly 
145                 150                 155                 160 


Lys Glu Glu Gly Lys Ile Phe Thr Gly Lys Asp Arg Met Val Gly Ile 
                165                 170                 175     


Asp Glu Thr Arg Lys Asn Leu Gln Lys Gln Thr Leu Gly Ala Tyr Leu 
            180                 185                 190         


Tyr Asp Ile Ala Pro Lys Asn Gly Glu Lys Tyr Arg Phe Arg Thr Glu 
        195                 200                 205             


Arg Val Arg Ala Arg Tyr Thr Leu Arg Asp Met Tyr Ile Arg Glu Phe 
    210                 215                 220                 


Glu Ile Ile Trp Gln Arg Gln Ala Gly His Leu Gly Leu Ala His Glu 
225                 230                 235                 240 


Gln Ala Thr Arg Lys Lys Asn Ile Phe Leu Glu Gly Ser Ala Thr Asn 
                245                 250                 255     


Val Arg Asn Ser Lys Leu Ile Thr His Leu Gln Ala Lys Tyr Gly Arg 
            260                 265                 270         


Gly His Val Leu Ile Glu Asp Thr Arg Ile Thr Val Thr Phe Gln Leu 
        275                 280                 285             


Pro Leu Lys Glu Val Leu Gly Gly Lys Ile Glu Ile Glu Glu Glu Gln 
    290                 295                 300                 


Leu Lys Phe Lys Ser Asn Glu Ser Val Leu Phe Trp Gln Arg Pro Leu 
305                 310                 315                 320 


Arg Ser Gln Lys Ser Leu Leu Ser Lys Cys Val Phe Glu Gly Arg Asn 
                325                 330                 335     


Phe Tyr Asp Pro Val His Gln Lys Trp Ile Ile Ala Gly Pro Thr Pro 
            340                 345                 350         


Ala Pro Leu Ser His Pro Glu Phe Glu Glu Phe Arg Ala Tyr Gln Phe 
        355                 360                 365             


Ile Asn Asn Ile Ile Tyr Gly Lys Asn Glu His Leu Thr Ala Ile Gln 
    370                 375                 380                 


Arg Glu Ala Val Phe Glu Leu Met Cys Thr Glu Ser Lys Asp Phe Asn 
385                 390                 395                 400 


Phe Glu Lys Ile Pro Lys His Leu Lys Leu Phe Glu Lys Phe Asn Phe 
                405                 410                 415     


Asp Asp Thr Thr Lys Val Pro Ala Cys Thr Thr Ile Ser Gln Leu Arg 
            420                 425                 430         


Lys Leu Phe Pro His Pro Val Trp Glu Glu Lys Arg Glu Glu Ile Trp 
        435                 440                 445             


His Cys Phe Tyr Phe Tyr Asp Asp Asn Thr Leu Leu Phe Glu Lys Leu 
    450                 455                 460                 


Gln Lys Asp Tyr Ala Leu Gln Thr Asn Asp Leu Glu Lys Ile Lys Lys 
465                 470                 475                 480 


Ile Arg Leu Ser Glu Ser Tyr Gly Asn Val Ser Leu Lys Ala Ile Arg 
                485                 490                 495     


Arg Ile Asn Pro Tyr Leu Lys Lys Gly Tyr Ala Tyr Ser Thr Ala Val 
            500                 505                 510         


Leu Leu Gly Gly Ile Arg Asn Ser Phe Gly Lys Arg Phe Glu Tyr Phe 
        515                 520                 525             


Lys Glu Tyr Glu Pro Glu Ile Glu Lys Ala Val Cys Arg Ile Leu Lys 
    530                 535                 540                 


Glu Lys Asn Ala Glu Gly Glu Val Ile Arg Lys Ile Lys Asp Tyr Leu 
545                 550                 555                 560 


Val His Asn Arg Phe Gly Phe Ala Lys Asn Asp Arg Ala Phe Gln Lys 
                565                 570                 575     


Leu Tyr His His Ser Gln Ala Ile Thr Thr Gln Ala Gln Lys Glu Arg 
            580                 585                 590         


Leu Pro Glu Thr Gly Asn Leu Arg Asn Pro Ile Val Gln Gln Gly Leu 
        595                 600                 605             


Asn Glu Leu Arg Arg Thr Val Asn Lys Leu Leu Ala Thr Cys Arg Glu 
    610                 615                 620                 


Lys Tyr Gly Pro Ser Phe Lys Phe Asp His Ile His Val Glu Met Gly 
625                 630                 635                 640 


Arg Glu Leu Arg Ser Ser Lys Thr Glu Arg Glu Lys Gln Ser Arg Gln 
                645                 650                 655     


Ile Arg Glu Asn Glu Lys Lys Asn Glu Ala Ala Lys Val Lys Leu Ala 
            660                 665                 670         


Glu Tyr Gly Leu Lys Ala Tyr Arg Asp Asn Ile Gln Lys Tyr Leu Leu 
        675                 680                 685             


Tyr Lys Glu Ile Glu Glu Lys Gly Gly Thr Val Cys Cys Pro Tyr Thr 
    690                 695                 700                 


Gly Lys Thr Leu Asn Ile Ser His Thr Leu Gly Ser Asp Asn Ser Val 
705                 710                 715                 720 


Gln Ile Glu His Ile Ile Pro Tyr Ser Ile Ser Leu Asp Asp Ser Leu 
                725                 730                 735     


Ala Asn Lys Thr Leu Cys Asp Ala Thr Phe Asn Arg Glu Lys Gly Glu 
            740                 745                 750         


Leu Thr Pro Tyr Asp Phe Tyr Gln Lys Asp Pro Ser Pro Glu Lys Trp 
        755                 760                 765             


Gly Ala Ser Ser Trp Glu Glu Ile Glu Asp Arg Ala Phe Arg Leu Leu 
    770                 775                 780                 


Pro Tyr Ala Lys Ala Gln Arg Phe Ile Arg Arg Lys Pro Gln Glu Ser 
785                 790                 795                 800 


Asn Glu Phe Ile Ser Arg Gln Leu Asn Asp Thr Arg Tyr Ile Ser Lys 
                805                 810                 815     


Lys Ala Val Glu Tyr Leu Ser Ala Ile Cys Ser Asp Val Lys Ala Phe 
            820                 825                 830         


Pro Gly Gln Leu Thr Ala Glu Leu Arg His Leu Trp Gly Leu Asn Asn 
        835                 840                 845             


Ile Leu Gln Ser Ala Pro Asp Ile Thr Phe Pro Leu Pro Val Ser Ala 
    850                 855                 860                 


Thr Glu Asn His Arg Glu Tyr Tyr Val Ile Thr Asn Glu Gln Asn Glu 
865                 870                 875                 880 


Val Ile Arg Leu Phe Pro Lys Gln Gly Glu Thr Pro Arg Thr Glu Lys 
                885                 890                 895     


Gly Glu Leu Leu Leu Thr Gly Glu Val Glu Arg Lys Val Phe Arg Cys 
            900                 905                 910         


Lys Gly Met Gln Glu Phe Gln Thr Asp Val Ser Asp Gly Lys Tyr Trp 
        915                 920                 925             


Arg Arg Ile Lys Leu Ser Ser Ser Val Thr Trp Ser Pro Leu Phe Ala 
    930                 935                 940                 


Pro Lys Pro Ile Ser Ala Asp Gly Gln Ile Val Leu Lys Gly Arg Ile 
945                 950                 955                 960 


Glu Lys Gly Val Phe Val Cys Asn Gln Leu Lys Gln Lys Leu Lys Thr 
                965                 970                 975     


Gly Leu Pro Asp Gly Ser Tyr Trp Ile Ser Leu Pro Val Ile Ser Gln 
            980                 985                 990         


Thr Phe Lys Glu Gly Glu Ser Val  Asn Asn Ser Lys Leu  Thr Ser Gln 
        995                 1000                 1005             


Gln Val  Gln Leu Phe Gly Arg  Val Arg Glu Gly Ile  Phe Arg Cys 
    1010                 1015                 1020             


His Asn  Tyr Gln Cys Pro Ala  Ser Gly Ala Asp Gly  Asn Phe Trp 
    1025                 1030                 1035             


Cys Thr  Leu Asp Thr Asp Thr  Ala Gln Pro Ala Phe  Thr Pro Ile 
    1040                 1045                 1050             


Lys Asn  Ala Pro Pro Gly Val  Gly Gly Gly Gln Ile  Ile Leu Thr 
    1055                 1060                 1065             


Gly Asp  Val Asp Asp Lys Gly  Ile Phe His Ala Asp  Asp Asp Leu 
    1070                 1075                 1080             


His Tyr  Glu Leu Pro Ala Ser  Leu Pro Lys Gly Lys  Tyr Tyr Gly 
    1085                 1090                 1095             


Ile Phe  Thr Val Glu Ser Cys  Asp Pro Thr Leu Ile  Pro Ile Glu 
    1100                 1105                 1110             


Leu Ser  Ala Pro Lys Thr Ser  Lys Gly Glu Asn Leu  Ile Glu Gly 
    1115                 1120                 1125             


Asn Ile  Trp Val Asp Glu His  Thr Gly Glu Val Arg  Phe Asp Pro 
    1130                 1135                 1140             


Lys Lys  Asn Arg Glu Asp Gln  Arg His His Ala Ile  Asp Ala Ile 
    1145                 1150                 1155             


Val Ile  Ala Leu Ser Ser Gln  Ser Leu Phe Gln Arg  Leu Ser Thr 
    1160                 1165                 1170             


Tyr Asn  Ala Arg Arg Glu Asn  Lys Lys Arg Gly Leu  Asp Ser Thr 
    1175                 1180                 1185             


Glu His  Phe Pro Ser Pro Trp  Pro Gly Phe Ala Gln  Asp Val Arg 
    1190                 1195                 1200             


Gln Ser  Val Val Pro Leu Leu  Val Ser Tyr Lys Gln  Asn Pro Lys 
    1205                 1210                 1215             


Thr Leu  Cys Lys Ile Ser Lys  Thr Leu Tyr Lys Asp  Gly Lys Lys 
    1220                 1225                 1230             


Ile His  Ser Cys Gly Asn Ala  Val Arg Gly Gln Leu  His Lys Glu 
    1235                 1240                 1245             


Thr Val  Tyr Gly Gln Arg Thr  Ala Pro Gly Ala Thr  Glu Lys Ser 
    1250                 1255                 1260             


Tyr His  Ile Arg Lys Asp Ile  Arg Glu Leu Lys Thr  Ser Lys His 
    1265                 1270                 1275             


Ile Gly  Lys Val Val Asp Ile  Thr Ile Arg Gln Met  Leu Leu Lys 
    1280                 1285                 1290             


His Leu  Gln Glu Asn Tyr His  Ile Asp Ile Thr Gln  Glu Phe Asn 
    1295                 1300                 1305             


Ile Pro  Ser Asn Ala Phe Phe  Lys Glu Gly Val Tyr  Arg Ile Phe 
    1310                 1315                 1320             


Leu Pro  Asn Lys His Gly Glu  Pro Val Pro Ile Lys  Lys Ile Arg 
    1325                 1330                 1335             


Met Lys  Glu Glu Leu Gly Asn  Ala Glu Arg Leu Lys  Asp Asn Ile 
    1340                 1345                 1350             


Asn Gln  Tyr Val Asn Pro Arg  Asn Asn His His Val  Met Ile Tyr 
    1355                 1360                 1365             


Gln Asp  Ala Asp Gly Asn Leu  Lys Glu Glu Ile Val  Ser Phe Trp 
    1370                 1375                 1380             


Ser Val  Ile Glu Arg Gln Asn  Gln Gly Gln Pro Ile  Tyr Gln Leu 
    1385                 1390                 1395             


Pro Arg  Glu Gly Arg Asn Ile  Val Ser Ile Leu Gln  Ile Asn Asp 
    1400                 1405                 1410             


Thr Phe  Leu Ile Gly Leu Lys  Glu Glu Glu Pro Glu  Val Tyr Arg 
    1415                 1420                 1425             


Asn Asp  Leu Ser Thr Leu Ser  Lys His Leu Tyr Arg  Val Gln Lys 
    1430                 1435                 1440             


Leu Ser  Gly Met Tyr Tyr Thr  Phe Arg His His Leu  Ala Ser Thr 
    1445                 1450                 1455             


Leu Asn  Asn Glu Arg Glu Glu  Phe Arg Ile Gln Ser  Leu Glu Ala 
    1460                 1465                 1470             


Trp Lys  Arg Ala Asn Pro Val  Lys Val Gln Ile Asp  Glu Ile Gly 
    1475                 1480                 1485             


Arg Ile  Thr Phe Leu Asn Gly  Pro Leu Cys 
    1490                 1495             


<210> 370
<211> 1389
<212> PRT
<213> Oenococcus kitaharae


<220>
<223> Oenococcus kitaharae DSM 17330

<400> 370
Met Ala Arg Asp Tyr Ser Val Gly Leu Asp Ile Gly Thr Ser Ser Val 
1               5                   10                  15      


Gly Trp Ala Ala Ile Asp Asn Lys Tyr His Leu Ile Arg Ala Lys Ser 
            20                  25                  30          


Lys Asn Leu Ile Gly Val Arg Leu Phe Asp Ser Ala Val Thr Ala Glu 
        35                  40                  45              


Lys Arg Arg Gly Tyr Arg Thr Thr Arg Arg Arg Leu Ser Arg Arg His 
    50                  55                  60                  


Trp Arg Leu Arg Leu Leu Asn Asp Ile Phe Ala Gly Pro Leu Thr Asp 
65                  70                  75                  80  


Phe Gly Asp Glu Asn Phe Leu Ala Arg Leu Lys Tyr Ser Trp Val His 
                85                  90                  95      


Pro Gln Asp Gln Ser Asn Gln Ala His Phe Ala Ala Gly Leu Leu Phe 
            100                 105                 110         


Asp Ser Lys Glu Gln Asp Lys Asp Phe Tyr Arg Lys Tyr Pro Thr Ile 
        115                 120                 125             


Tyr His Leu Arg Leu Ala Leu Met Asn Asp Asp Gln Lys His Asp Leu 
    130                 135                 140                 


Arg Glu Val Tyr Leu Ala Ile His His Leu Val Lys Tyr Arg Gly His 
145                 150                 155                 160 


Phe Leu Ile Glu Gly Asp Val Lys Ala Asp Ser Ala Phe Asp Val His 
                165                 170                 175     


Thr Phe Ala Asp Ala Ile Gln Arg Tyr Ala Glu Ser Asn Asn Ser Asp 
            180                 185                 190         


Glu Asn Leu Leu Gly Lys Ile Asp Glu Lys Lys Leu Ser Ala Ala Leu 
        195                 200                 205             


Thr Asp Lys His Gly Ser Lys Ser Gln Arg Ala Glu Thr Ala Glu Thr 
    210                 215                 220                 


Ala Phe Asp Ile Leu Asp Leu Gln Ser Lys Lys Gln Ile Gln Ala Ile 
225                 230                 235                 240 


Leu Lys Ser Val Val Gly Asn Gln Ala Asn Leu Met Ala Ile Phe Gly 
                245                 250                 255     


Leu Asp Ser Ser Ala Ile Ser Lys Asp Glu Gln Lys Asn Tyr Lys Phe 
            260                 265                 270         


Ser Phe Asp Asp Ala Asp Ile Asp Glu Lys Ile Ala Asp Ser Glu Ala 
        275                 280                 285             


Leu Leu Ser Asp Thr Glu Phe Glu Phe Leu Cys Asp Leu Lys Ala Ala 
    290                 295                 300                 


Phe Asp Gly Leu Thr Leu Lys Met Leu Leu Gly Asp Asp Lys Thr Val 
305                 310                 315                 320 


Ser Ala Ala Met Val Arg Arg Phe Asn Glu His Gln Lys Asp Trp Glu 
                325                 330                 335     


Tyr Ile Lys Ser His Ile Arg Asn Ala Lys Asn Ala Gly Asn Gly Leu 
            340                 345                 350         


Tyr Glu Lys Ser Lys Lys Phe Asp Gly Ile Asn Ala Ala Tyr Leu Ala 
        355                 360                 365             


Leu Gln Ser Asp Asn Glu Asp Asp Arg Lys Lys Ala Lys Lys Ile Phe 
    370                 375                 380                 


Gln Asp Glu Ile Ser Ser Ala Asp Ile Pro Asp Asp Val Lys Ala Asp 
385                 390                 395                 400 


Phe Leu Lys Lys Ile Asp Asp Asp Gln Phe Leu Pro Ile Gln Arg Thr 
                405                 410                 415     


Lys Asn Asn Gly Thr Ile Pro His Gln Leu His Arg Asn Glu Leu Glu 
            420                 425                 430         


Gln Ile Ile Glu Lys Gln Gly Ile Tyr Tyr Pro Phe Leu Lys Asp Thr 
        435                 440                 445             


Tyr Gln Glu Asn Ser His Glu Leu Asn Lys Ile Thr Ala Leu Ile Asn 
    450                 455                 460                 


Phe Arg Val Pro Tyr Tyr Val Gly Pro Leu Val Glu Glu Glu Gln Lys 
465                 470                 475                 480 


Ile Ala Asp Asp Gly Lys Asn Ile Pro Asp Pro Thr Asn His Trp Met 
                485                 490                 495     


Val Arg Lys Ser Asn Asp Thr Ile Thr Pro Trp Asn Leu Ser Gln Val 
            500                 505                 510         


Val Asp Leu Asp Lys Ser Gly Arg Arg Phe Ile Glu Arg Leu Thr Gly 
        515                 520                 525             


Thr Asp Thr Tyr Leu Ile Gly Glu Pro Thr Leu Pro Lys Asn Ser Leu 
    530                 535                 540                 


Leu Tyr Gln Lys Phe Asp Val Leu Gln Glu Leu Asn Asn Ile Arg Val 
545                 550                 555                 560 


Ser Gly Arg Arg Leu Asp Ile Arg Ala Lys Gln Asp Ala Phe Glu His 
                565                 570                 575     


Leu Phe Lys Val Gln Lys Thr Val Ser Ala Thr Asn Leu Lys Asp Phe 
            580                 585                 590         


Leu Val Gln Ala Gly Tyr Ile Ser Glu Asp Thr Gln Ile Glu Gly Leu 
        595                 600                 605             


Ala Asp Val Asn Gly Lys Asn Phe Asn Asn Ala Leu Thr Thr Tyr Asn 
    610                 615                 620                 


Tyr Leu Val Ser Val Leu Gly Arg Glu Phe Val Glu Asn Pro Ser Asn 
625                 630                 635                 640 


Glu Glu Leu Leu Glu Glu Ile Thr Glu Leu Gln Thr Val Phe Glu Asp 
                645                 650                 655     


Lys Lys Val Leu Arg Arg Gln Leu Asp Gln Leu Asp Gly Leu Ser Asp 
            660                 665                 670         


His Asn Arg Glu Lys Leu Ser Arg Lys His Tyr Thr Gly Trp Gly Arg 
        675                 680                 685             


Ile Ser Lys Lys Leu Leu Thr Thr Lys Ile Val Gln Asn Ala Asp Lys 
    690                 695                 700                 


Ile Asp Asn Gln Thr Phe Asp Val Pro Arg Met Asn Gln Ser Ile Ile 
705                 710                 715                 720 


Asp Thr Leu Tyr Asn Thr Lys Met Asn Leu Met Glu Ile Ile Asn Asn 
                725                 730                 735     


Ala Glu Asp Asp Phe Gly Val Arg Ala Trp Ile Asp Lys Gln Asn Thr 
            740                 745                 750         


Thr Asp Gly Asp Glu Gln Asp Val Tyr Ser Leu Ile Asp Glu Leu Ala 
        755                 760                 765             


Gly Pro Lys Glu Ile Lys Arg Gly Ile Val Gln Ser Phe Arg Ile Leu 
    770                 775                 780                 


Asp Asp Ile Thr Lys Ala Val Gly Tyr Ala Pro Lys Arg Val Tyr Leu 
785                 790                 795                 800 


Glu Phe Ala Arg Lys Thr Gln Glu Ser His Leu Thr Asn Ser Arg Lys 
                805                 810                 815     


Asn Gln Leu Ser Thr Leu Leu Lys Asn Ala Gly Leu Ser Glu Leu Val 
            820                 825                 830         


Thr Gln Val Ser Gln Tyr Asp Ala Ala Ala Leu Gln Asn Asp Arg Leu 
        835                 840                 845             


Tyr Leu Tyr Phe Leu Gln Gln Gly Lys Asp Met Tyr Ser Gly Glu Lys 
    850                 855                 860                 


Leu Asn Leu Asp Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Ile Pro 
865                 870                 875                 880 


Gln Ala Tyr Thr Lys Asp Asn Ser Leu Asp Asn Arg Val Leu Val Ser 
                885                 890                 895     


Asn Ile Thr Asn Arg Arg Lys Ser Asp Ser Ser Asn Tyr Leu Pro Ala 
            900                 905                 910         


Leu Ile Asp Lys Met Arg Pro Phe Trp Ser Val Leu Ser Lys Gln Gly 
        915                 920                 925             


Leu Leu Ser Lys His Lys Phe Ala Asn Leu Thr Arg Thr Arg Asp Phe 
    930                 935                 940                 


Asp Asp Met Glu Lys Glu Arg Phe Ile Ala Arg Ser Leu Val Glu Thr 
945                 950                 955                 960 


Arg Gln Ile Ile Lys Asn Val Ala Ser Leu Ile Asp Ser His Phe Gly 
                965                 970                 975     


Gly Glu Thr Lys Ala Val Ala Ile Arg Ser Ser Leu Thr Ala Asp Met 
            980                 985                 990         


Arg Arg Tyr Val Asp Ile Pro Lys  Asn Arg Asp Ile Asn  Asp Tyr His 
        995                 1000                 1005             


His Ala  Phe Asp Ala Leu Leu  Phe Ser Thr Val Gly  Gln Tyr Thr 
    1010                 1015                 1020             


Glu Asn  Ser Gly Leu Met Lys  Lys Gly Gln Leu Ser  Asp Ser Ala 
    1025                 1030                 1035             


Gly Asn  Gln Tyr Asn Arg Tyr  Ile Lys Glu Trp Ile  His Ala Ala 
    1040                 1045                 1050             


Arg Leu  Asn Ala Gln Ser Gln  Arg Val Asn Pro Phe  Gly Phe Val 
    1055                 1060                 1065             


Val Gly  Ser Met Arg Asn Ala  Ala Pro Gly Lys Leu  Asn Pro Glu 
    1070                 1075                 1080             


Thr Gly  Glu Ile Thr Pro Glu  Glu Asn Ala Asp Trp  Ser Ile Ala 
    1085                 1090                 1095             


Asp Leu  Asp Tyr Leu His Lys  Val Met Asn Phe Arg  Lys Ile Thr 
    1100                 1105                 1110             


Val Thr  Arg Arg Leu Lys Asp  Gln Lys Gly Gln Leu  Tyr Asp Glu 
    1115                 1120                 1125             


Ser Arg  Tyr Pro Ser Val Leu  His Asp Ala Lys Ser  Lys Ala Ser 
    1130                 1135                 1140             


Ile Asn  Phe Asp Lys His Lys  Pro Val Asp Leu Tyr  Gly Gly Phe 
    1145                 1150                 1155             


Ser Ser  Ala Lys Pro Ala Tyr  Ala Ala Leu Ile Lys  Phe Lys Asn 
    1160                 1165                 1170             


Lys Phe  Arg Leu Val Asn Val  Leu Arg Gln Trp Thr  Tyr Ser Asp 
    1175                 1180                 1185             


Lys Asn  Ser Glu Asp Tyr Ile  Leu Glu Gln Ile Arg  Gly Lys Tyr 
    1190                 1195                 1200             


Pro Lys  Ala Glu Met Val Leu  Ser His Ile Pro Tyr  Gly Gln Leu 
    1205                 1210                 1215             


Val Lys  Lys Asp Gly Ala Leu  Val Thr Ile Ser Ser  Ala Thr Glu 
    1220                 1225                 1230             


Leu His  Asn Phe Glu Gln Leu  Trp Leu Pro Leu Ala  Asp Tyr Lys 
    1235                 1240                 1245             


Leu Ile  Asn Thr Leu Leu Lys  Thr Lys Glu Asp Asn  Leu Val Asp 
    1250                 1255                 1260             


Ile Leu  His Asn Arg Leu Asp  Leu Pro Glu Met Thr  Ile Glu Ser 
    1265                 1270                 1275             


Ala Phe  Tyr Lys Ala Phe Asp  Ser Ile Leu Ser Phe  Ala Phe Asn 
    1280                 1285                 1290             


Arg Tyr  Ala Leu His Gln Asn  Ala Leu Val Lys Leu  Gln Ala His 
    1295                 1300                 1305             


Arg Asp  Asp Phe Asn Ala Leu  Asn Tyr Glu Asp Lys  Gln Gln Thr 
    1310                 1315                 1320             


Leu Glu  Arg Ile Leu Asp Ala  Leu His Ala Ser Pro  Ala Ser Ser 
    1325                 1330                 1335             


Asp Leu  Lys Lys Ile Asn Leu  Ser Ser Gly Phe Gly  Arg Leu Phe 
    1340                 1345                 1350             


Ser Pro  Ser His Phe Thr Leu  Ala Asp Thr Asp Glu  Phe Ile Phe 
    1355                 1360                 1365             


Gln Ser  Val Thr Gly Leu Phe  Ser Thr Gln Lys Thr  Val Ala Gln 
    1370                 1375                 1380             


Leu Tyr  Gln Glu Thr Lys 
    1385                 


<210> 371
<211> 1389
<212> PRT
<213> Oenococcus kitaharae


<220>
<223> Oenococcus kitaharae DSM 17330

<400> 371
Met Ala Arg Asp Tyr Ser Val Gly Leu Asp Ile Gly Thr Ser Ser Val 
1               5                   10                  15      


Gly Trp Ala Ala Ile Asp Asn Lys Tyr His Leu Ile Arg Ala Lys Ser 
            20                  25                  30          


Lys Asn Leu Ile Gly Val Arg Leu Phe Asp Ser Ala Val Thr Ala Glu 
        35                  40                  45              


Lys Arg Arg Gly Tyr Arg Thr Thr Arg Arg Arg Leu Ser Arg Arg His 
    50                  55                  60                  


Trp Arg Leu Arg Leu Leu Asn Asp Ile Phe Ala Gly Pro Leu Thr Asp 
65                  70                  75                  80  


Phe Gly Asp Glu Asn Phe Leu Ala Arg Leu Lys Tyr Ser Trp Val His 
                85                  90                  95      


Pro Gln Asp Gln Ser Asn Gln Ala His Phe Ala Ala Gly Leu Leu Phe 
            100                 105                 110         


Asp Ser Lys Glu Gln Asp Lys Asp Phe Tyr Arg Lys Tyr Pro Thr Ile 
        115                 120                 125             


Tyr His Leu Arg Leu Ala Leu Met Asn Asp Asp Gln Lys His Asp Leu 
    130                 135                 140                 


Arg Glu Val Tyr Leu Ala Ile His His Leu Val Lys Tyr Arg Gly His 
145                 150                 155                 160 


Phe Leu Ile Glu Gly Asp Val Lys Ala Asp Ser Ala Phe Asp Val His 
                165                 170                 175     


Thr Phe Ala Asp Ala Ile Gln Arg Tyr Ala Glu Ser Asn Asn Ser Asp 
            180                 185                 190         


Glu Asn Leu Leu Gly Lys Ile Asp Glu Lys Lys Leu Ser Ala Ala Leu 
        195                 200                 205             


Thr Asp Lys His Gly Ser Lys Ser Gln Arg Ala Glu Thr Ala Glu Thr 
    210                 215                 220                 


Ala Phe Asp Ile Leu Asp Leu Gln Ser Lys Lys Gln Ile Gln Ala Ile 
225                 230                 235                 240 


Leu Lys Ser Val Val Gly Asn Gln Ala Asn Leu Met Ala Ile Phe Gly 
                245                 250                 255     


Leu Asp Ser Ser Ala Ile Ser Lys Asp Glu Gln Lys Asn Tyr Lys Phe 
            260                 265                 270         


Ser Phe Asp Asp Ala Asp Ile Asp Glu Lys Ile Ala Asp Ser Glu Ala 
        275                 280                 285             


Leu Leu Ser Asp Thr Glu Phe Glu Phe Leu Cys Asp Leu Lys Ala Ala 
    290                 295                 300                 


Phe Asp Gly Leu Thr Leu Lys Met Leu Leu Gly Asp Asp Lys Thr Val 
305                 310                 315                 320 


Ser Ala Ala Met Val Arg Arg Phe Asn Glu His Gln Lys Asp Trp Glu 
                325                 330                 335     


Tyr Ile Lys Ser His Ile Arg Asn Ala Lys Asn Ala Gly Asn Gly Leu 
            340                 345                 350         


Tyr Glu Lys Ser Lys Lys Phe Asp Gly Ile Asn Ala Ala Tyr Leu Ala 
        355                 360                 365             


Leu Gln Ser Asp Asn Glu Asp Asp Arg Lys Lys Ala Lys Lys Ile Phe 
    370                 375                 380                 


Gln Asp Glu Ile Ser Ser Ala Asp Ile Pro Asp Asp Val Lys Ala Asp 
385                 390                 395                 400 


Phe Leu Lys Lys Ile Asp Asp Asp Gln Phe Leu Pro Ile Gln Arg Thr 
                405                 410                 415     


Lys Asn Asn Gly Thr Ile Pro His Gln Leu His Arg Asn Glu Leu Glu 
            420                 425                 430         


Gln Ile Ile Glu Lys Gln Gly Ile Tyr Tyr Pro Phe Leu Lys Asp Thr 
        435                 440                 445             


Tyr Gln Glu Asn Ser His Glu Leu Asn Lys Ile Thr Ala Leu Ile Asn 
    450                 455                 460                 


Phe Arg Val Pro Tyr Tyr Val Gly Pro Leu Val Glu Glu Glu Gln Lys 
465                 470                 475                 480 


Ile Ala Asp Asp Gly Lys Asn Ile Pro Asp Pro Thr Asn His Trp Met 
                485                 490                 495     


Val Arg Lys Ser Asn Asp Thr Ile Thr Pro Trp Asn Leu Ser Gln Val 
            500                 505                 510         


Val Asp Leu Asp Lys Ser Gly Arg Arg Phe Ile Glu Arg Leu Thr Gly 
        515                 520                 525             


Thr Asp Thr Tyr Leu Ile Gly Glu Pro Thr Leu Pro Lys Asn Ser Leu 
    530                 535                 540                 


Leu Tyr Gln Lys Phe Asp Val Leu Gln Glu Leu Asn Asn Ile Arg Val 
545                 550                 555                 560 


Ser Gly Arg Arg Leu Asp Ile Arg Ala Lys Gln Asp Ala Phe Glu His 
                565                 570                 575     


Leu Phe Lys Val Gln Lys Thr Val Ser Ala Thr Asn Leu Lys Asp Phe 
            580                 585                 590         


Leu Val Gln Ala Gly Tyr Ile Ser Glu Asp Thr Gln Ile Glu Gly Leu 
        595                 600                 605             


Ala Asp Val Asn Gly Lys Asn Phe Asn Asn Ala Leu Thr Thr Tyr Asn 
    610                 615                 620                 


Tyr Leu Val Ser Val Leu Gly Arg Glu Phe Val Glu Asn Pro Ser Asn 
625                 630                 635                 640 


Glu Glu Leu Leu Glu Glu Ile Thr Glu Leu Gln Thr Val Phe Glu Asp 
                645                 650                 655     


Lys Lys Val Leu Arg Arg Gln Leu Asp Gln Leu Asp Gly Leu Ser Asp 
            660                 665                 670         


His Asn Arg Glu Lys Leu Ser Arg Lys His Tyr Thr Gly Trp Gly Arg 
        675                 680                 685             


Ile Ser Lys Lys Leu Leu Thr Thr Lys Ile Val Gln Asn Ala Asp Lys 
    690                 695                 700                 


Ile Asp Asn Gln Thr Phe Asp Val Pro Arg Met Asn Gln Ser Ile Ile 
705                 710                 715                 720 


Asp Thr Leu Tyr Asn Thr Lys Met Asn Leu Met Glu Ile Ile Asn Asn 
                725                 730                 735     


Ala Glu Asp Asp Phe Gly Val Arg Ala Trp Ile Asp Lys Gln Asn Thr 
            740                 745                 750         


Thr Asp Gly Asp Glu Gln Asp Val Tyr Ser Leu Ile Asp Glu Leu Ala 
        755                 760                 765             


Gly Pro Lys Glu Ile Lys Arg Gly Ile Val Gln Ser Phe Arg Ile Leu 
    770                 775                 780                 


Asp Asp Ile Thr Lys Ala Val Gly Tyr Ala Pro Lys Arg Val Tyr Leu 
785                 790                 795                 800 


Glu Phe Ala Arg Lys Thr Gln Glu Ser His Leu Thr Asn Ser Arg Lys 
                805                 810                 815     


Asn Gln Leu Ser Thr Leu Leu Lys Asn Ala Gly Leu Ser Glu Leu Val 
            820                 825                 830         


Thr Gln Val Ser Gln Tyr Asp Ala Ala Ala Leu Gln Asn Asp Arg Leu 
        835                 840                 845             


Tyr Leu Tyr Phe Leu Gln Gln Gly Lys Asp Met Tyr Ser Gly Glu Lys 
    850                 855                 860                 


Leu Asn Leu Asp Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Ile Pro 
865                 870                 875                 880 


Gln Ala Tyr Thr Lys Asp Asn Ser Leu Asp Asn Arg Val Leu Val Ser 
                885                 890                 895     


Asn Ile Thr Asn Arg Arg Lys Ser Asp Ser Ser Asn Tyr Leu Pro Ala 
            900                 905                 910         


Leu Ile Asp Lys Met Arg Pro Phe Trp Ser Val Leu Ser Lys Gln Gly 
        915                 920                 925             


Leu Leu Ser Lys His Lys Phe Ala Asn Leu Thr Arg Thr Arg Asp Phe 
    930                 935                 940                 


Asp Asp Met Glu Lys Glu Arg Phe Ile Ala Arg Ser Leu Val Glu Thr 
945                 950                 955                 960 


Arg Gln Ile Ile Lys Asn Val Ala Ser Leu Ile Asp Ser His Phe Gly 
                965                 970                 975     


Gly Glu Thr Lys Ala Val Ala Ile Arg Ser Ser Leu Thr Ala Asp Met 
            980                 985                 990         


Arg Arg Tyr Val Asp Ile Pro Lys  Asn Arg Asp Ile Asn  Asp Tyr His 
        995                 1000                 1005             


His Ala  Phe Asp Ala Leu Leu  Phe Ser Thr Val Gly  Gln Tyr Thr 
    1010                 1015                 1020             


Glu Asn  Ser Gly Leu Met Lys  Lys Gly Gln Leu Ser  Asp Ser Ala 
    1025                 1030                 1035             


Gly Asn  Gln Tyr Asn Arg Tyr  Ile Lys Glu Trp Ile  His Ala Ala 
    1040                 1045                 1050             


Arg Leu  Asn Ala Gln Ser Gln  Arg Val Asn Pro Phe  Gly Phe Val 
    1055                 1060                 1065             


Val Gly  Ser Met Arg Asn Ala  Ala Pro Gly Lys Leu  Asn Pro Glu 
    1070                 1075                 1080             


Thr Gly  Glu Ile Thr Pro Glu  Glu Asn Ala Asp Trp  Ser Ile Ala 
    1085                 1090                 1095             


Asp Leu  Asp Tyr Leu His Lys  Val Met Asn Phe Arg  Lys Ile Thr 
    1100                 1105                 1110             


Val Thr  Arg Arg Leu Lys Asp  Gln Lys Gly Gln Leu  Tyr Asp Glu 
    1115                 1120                 1125             


Ser Arg  Tyr Pro Ser Val Leu  His Asp Ala Lys Ser  Lys Ala Ser 
    1130                 1135                 1140             


Ile Asn  Phe Asp Lys His Lys  Pro Val Asp Leu Tyr  Gly Gly Phe 
    1145                 1150                 1155             


Ser Ser  Ala Lys Pro Ala Tyr  Ala Ala Leu Ile Lys  Phe Lys Asn 
    1160                 1165                 1170             


Lys Phe  Arg Leu Val Asn Val  Leu Arg Gln Trp Thr  Tyr Ser Asp 
    1175                 1180                 1185             


Lys Asn  Ser Glu Asp Tyr Ile  Leu Glu Gln Ile Arg  Gly Lys Tyr 
    1190                 1195                 1200             


Pro Lys  Ala Glu Met Val Leu  Ser His Ile Pro Tyr  Gly Gln Leu 
    1205                 1210                 1215             


Val Lys  Lys Asp Gly Ala Leu  Val Thr Ile Ser Ser  Ala Thr Glu 
    1220                 1225                 1230             


Leu His  Asn Phe Glu Gln Leu  Trp Leu Pro Leu Ala  Asp Tyr Lys 
    1235                 1240                 1245             


Leu Ile  Asn Thr Leu Leu Lys  Thr Lys Glu Asp Asn  Leu Val Asp 
    1250                 1255                 1260             


Ile Leu  His Asn Arg Leu Asp  Leu Pro Glu Met Thr  Ile Glu Ser 
    1265                 1270                 1275             


Ala Phe  Tyr Lys Ala Phe Asp  Ser Ile Leu Ser Phe  Ala Phe Asn 
    1280                 1285                 1290             


Arg Tyr  Ala Leu His Gln Asn  Ala Leu Val Lys Leu  Gln Ala His 
    1295                 1300                 1305             


Arg Asp  Asp Phe Asn Ala Leu  Asn Tyr Glu Asp Lys  Gln Gln Thr 
    1310                 1315                 1320             


Leu Glu  Arg Ile Leu Asp Ala  Leu His Ala Ser Pro  Ala Ser Ser 
    1325                 1330                 1335             


Asp Leu  Lys Lys Ile Asn Leu  Ser Ser Gly Phe Gly  Arg Leu Phe 
    1340                 1345                 1350             


Ser Pro  Ser His Phe Thr Leu  Ala Asp Thr Asp Glu  Phe Ile Phe 
    1355                 1360                 1365             


Gln Ser  Val Thr Gly Leu Phe  Ser Thr Gln Lys Thr  Val Ala Gln 
    1370                 1375                 1380             


Leu Tyr  Gln Glu Thr Lys 
    1385                 


<210> 372
<211> 1399
<212> PRT
<213> Olsenella uli

<400> 372
Met Asn Leu Arg Asn Thr Thr Asp Glu Tyr Asn Ile Gly Leu Asp Met 
1               5                   10                  15      


Gly Thr Asn Ser Val Gly Trp Ala Val Thr Asp Lys Ala Gly Ala Ile 
            20                  25                  30          


Ala His Phe Lys Gly Lys Pro Thr Leu Gly Ser Arg Leu Phe Asp Ala 
        35                  40                  45              


Ala Gln Thr Ala Ala Gly Ala Arg Ile His Arg Ser Gln Arg Arg Arg 
    50                  55                  60                  


Tyr Val Arg Arg Arg Trp Arg Leu Asp Leu Leu Gln Ser Leu Phe Gln 
65                  70                  75                  80  


Asp Glu Val Ser Lys Val Asp Ser Glu Phe Phe Cys Arg Leu Arg Gln 
                85                  90                  95      


Ser Arg Leu Tyr Val Gly Asp Arg Glu Lys Gly His Ala Asp Tyr Thr 
            100                 105                 110         


Trp Pro Ile Phe Asn Asp Ser Asp Phe Asn Glu Val Asp Tyr Tyr Lys 
        115                 120                 125             


Arg Phe Pro Thr Ile Tyr His Leu Arg Lys Trp Leu Met Glu Thr Asp 
    130                 135                 140                 


Glu Lys Ala Asp Ile Arg Leu Ile Tyr Leu Ala Thr His Asn Ile Val 
145                 150                 155                 160 


Lys His Arg Gly Asn Phe Leu Arg Glu Asn Asn Lys Ser Leu Ser Ser 
                165                 170                 175     


Arg Asp Ala Asn Pro Ala Gln Ala Val Lys Ser Leu Arg Leu Ala Leu 
            180                 185                 190         


Asn Asp Trp Cys Ser Glu Arg Asp Tyr Glu Cys Ala Trp Lys Gly Glu 
        195                 200                 205             


Glu Asp Asp Gly Ala Ile Asp Glu Ala Ile Leu Asn Val Leu Ala Asp 
    210                 215                 220                 


Gly Glu Lys Gly Arg Ser Asp Gln Ala Lys Glu Ile Ala Lys Leu Thr 
225                 230                 235                 240 


Gly Val Asp Cys Gly Asp Ala Lys Gln Ser Lys Gln Cys Asn Glu Ala 
                245                 250                 255     


Ile Ala Lys Ala Ile Val Gly Leu Lys Val Glu Met Lys Asn Ile Phe 
            260                 265                 270         


Gly Glu Phe Pro Ala Glu Lys Thr Ser Tyr Ile Tyr Leu Ser Ser Asp 
        275                 280                 285             


Glu Asp Val Glu Ala Val Arg Glu Ser Cys Pro Asp Asp Ser Gly Glu 
    290                 295                 300                 


Leu Phe Gln Ala Leu Cys Lys Leu Tyr Ser Ala Tyr Ile Leu Gln Glu 
305                 310                 315                 320 


Leu Leu Ser Tyr Ala Asp Pro Ser Gly Gln Thr Ile Ser Ala Asn Met 
                325                 330                 335     


Val Ala Lys Tyr Lys Gln Tyr Gly Arg Asp Leu Arg Leu Leu Lys Glu 
            340                 345                 350         


Leu Thr Arg Thr Tyr Ala Pro Gln Lys Tyr Asp Leu Phe Phe Arg Gly 
        355                 360                 365             


Glu Thr Tyr Ala Gly Ser Ser Asp Tyr Val Val Asp Glu Ala Arg Gly 
    370                 375                 380                 


Tyr Thr Arg Tyr Asn Leu Gly Thr Thr Lys Ala Asn Tyr Asp Asp Phe 
385                 390                 395                 400 


Gln Lys Ser Val Lys Glu Leu Phe Lys Gly Thr Asp Ala Leu Gln Asp 
                405                 410                 415     


Glu Arg Tyr Gln Glu Met Met Val Ala Phe Gly Glu Gln Lys Phe Leu 
            420                 425                 430         


Arg Arg Leu Lys Thr Ser Asp Asn Gly Ser Ile Tyr Tyr Gln Leu His 
        435                 440                 445             


Leu Glu Glu Leu His Thr Ile Leu Glu Asn Gln Gly Lys His Tyr Pro 
    450                 455                 460                 


Phe Leu Leu Ser Glu Glu Asp Lys Ile Glu Ser Leu Val Ser Phe Arg 
465                 470                 475                 480 


Ile Pro Tyr Tyr Val Gly Pro Leu Thr Arg Lys Asn Ala Ala Ile Gly 
                485                 490                 495     


His Asp Gly Lys Glu Arg Phe Ala Trp Ser Ser Arg Lys Asp Gly Met 
            500                 505                 510         


Glu His Ala Val Ile Thr Pro Trp Asn Trp Glu Glu Ile Ile Asp Arg 
        515                 520                 525             


Asp Lys Ser Ala Glu Asp Phe Ile Met Arg Met Thr Gly Asp Cys Thr 
    530                 535                 540                 


Tyr Leu Gln Gly Glu Pro Val Leu Pro Lys Cys Ser Leu Leu Tyr Glu 
545                 550                 555                 560 


Glu Phe Cys Ala Leu Asn Glu Phe Asn Gly Ala His Trp Thr Val Asp 
                565                 570                 575     


Gly Asp Asp Glu Arg Arg Phe Asp Ala Ala Gln Arg Glu Arg Ile Met 
            580                 585                 590         


Cys Asp Leu Phe Arg Arg Thr Arg Ser Val Thr Tyr Asn Lys Val Ser 
        595                 600                 605             


Asp Trp Leu Glu Arg Lys Tyr Asn Phe Thr Gly Ala Arg Val Arg Gly 
    610                 615                 620                 


Gly Gln Gly Glu His Gly Phe Glu Ser Lys Leu Gly Ser Tyr Ile Phe 
625                 630                 635                 640 


Phe Cys Lys Asp Val Phe Lys Thr Asp Gly Leu Asp Glu Ala Asp Tyr 
                645                 650                 655     


Thr Met Ile Glu Gln Ile Ile Leu Trp Ser Thr Leu Phe Glu Asp Arg 
            660                 665                 670         


Asp Ile Leu Lys Arg Lys Ile Glu Glu Ala Tyr Gly Gly Asp Arg Leu 
        675                 680                 685             


Thr Ser Glu Gln Ile Lys Val Ile Cys Lys Lys Arg Phe Thr Gly Trp 
    690                 695                 700                 


Gly Arg Leu Ser Lys Arg Leu Leu Thr Asp Ile Lys Val Asn Thr Asp 
705                 710                 715                 720 


Thr Gly Arg Lys Ser Ile Met Asp Val Leu Arg Glu Gly Asn Pro Asn 
                725                 730                 735     


Asn Gly Gln Arg Ser Arg Thr Met Val Phe Met Glu Val Leu Arg Asp 
            740                 745                 750         


Glu Asp Leu Gly Phe Gln Lys Ala Ile Asp Gly Leu Asn Arg Asp Tyr 
        755                 760                 765             


Phe Arg Glu His Asn Asn Gly Leu Met Asp Val Asn Asp Leu Pro Gly 
    770                 775                 780                 


Ser Pro Ala Ile Arg Arg Ser Ile Asn Gln Ala Val Arg Ile Val Asp 
785                 790                 795                 800 


Glu Ile Ala Ser Ile Ala Arg Lys Glu Pro Thr Asn Ile Phe Ile Glu 
                805                 810                 815     


Val Thr Arg Glu Glu Asp Asp Pro Arg Lys Lys Gly Lys Arg Thr Lys 
            820                 825                 830         


Arg Arg Tyr Asp Ala Ile Lys Ser Ala Leu Glu Lys Phe Lys Lys Asp 
        835                 840                 845             


Asp Pro Ser Leu Trp Lys Glu Leu Cys Glu Lys Ala Pro Gly Asp Met 
    850                 855                 860                 


Asp Glu Arg Leu Ser Leu Tyr Phe Met Gln Arg Gly Lys Cys Met Tyr 
865                 870                 875                 880 


Ser Gly Arg Pro Ile Lys Ile Glu Glu Leu His Thr Gly Lys Tyr Glu 
                885                 890                 895     


Val Asp His Ile Ile Pro Arg Ser Tyr Ile Lys Asp Asp Ser Phe Glu 
            900                 905                 910         


Asn Lys Val Leu Val Tyr Arg Glu Glu Asn Gln His Lys Thr Asp Ala 
        915                 920                 925             


Leu Leu Ile Asp Ser Ser Ile Arg Gln Lys Met Gly Gly Tyr Trp Arg 
    930                 935                 940                 


Met Leu His Asp Ala Lys Leu Val Gly Asp Lys Lys Phe Arg Asn Leu 
945                 950                 955                 960 


Phe Arg Asn His Ile Asp Asp Lys Ala Met Lys Gly Phe Val Ala Arg 
                965                 970                 975     


Gln Ile Val Glu Thr Ser Gln Met Val Lys Leu Val Gln Thr Leu Phe 
            980                 985                 990         


Glu Ala Arg Tyr Pro Asn Thr Arg  Ile Val Pro Val Lys  Ala Gly Ile 
        995                 1000                 1005             


Ser His  Asp Leu Arg Glu Ala  Ala Gly Leu Val Lys  Cys Arg Glu 
    1010                 1015                 1020             


Ala Asn  Asp Phe His His Ala  His Asp Ala Phe Leu  Ala Cys Arg 
    1025                 1030                 1035             


Ile Gly  Leu Phe Ile Gln Lys  Arg His Pro Ser Val  Tyr Asp Asn 
    1040                 1045                 1050             


Pro Ile  Gly Leu Ala Arg Ile  Met Arg Asp Tyr Ala  Arg Met Gln 
    1055                 1060                 1065             


Ala Arg  Glu Tyr Lys Lys Ser  His Cys Leu Ala His  Thr Gln Gly 
    1070                 1075                 1080             


Phe Ile  Val Asn Ser Phe Leu  Ser Ser Gly Phe Asp  Glu Glu Thr 
    1085                 1090                 1095             


Gly Glu  Ile Phe Lys Asp Asp  Trp Asp Ala Lys Ala  Glu Val Glu 
    1100                 1105                 1110             


Gly Ile  Arg Arg Val Leu Asn  Cys Arg Gln Cys Phe  Ile Ser Arg 
    1115                 1120                 1125             


Met Pro  Val Glu Gly Asp Thr  Arg Tyr Gly Gly Arg  Tyr Trp Gly 
    1130                 1135                 1140             


Glu Thr  Ile Tyr Ser Pro Lys  Gly Lys His Lys His  Glu Ile Pro 
    1145                 1150                 1155             


Leu Lys  Gln Gly Leu Asp Pro  Asn Leu Tyr Gly Gly  Tyr Ser Asp 
    1160                 1165                 1170             


Leu Leu  Tyr Ser Tyr Phe Leu  Ile Tyr Glu Ala Ser  Asp Val Ser 
    1175                 1180                 1185             


Ser Gly  Glu Arg Val Leu Arg  Phe Ile Gly Ile Pro  Thr Ser Ile 
    1190                 1195                 1200             


Ala Ala  Arg Met Ala Asn Gln  Lys Arg Leu Glu Glu  Tyr Val Ser 
    1205                 1210                 1215             


Arg Leu  Ala Leu Gln Glu Asn  Leu Glu His Val Arg  Met Val Arg 
    1220                 1225                 1230             


Lys Ile  Met Lys Lys Gln Leu  Ile Glu Val Asp Asn  Cys Arg Leu 
    1235                 1240                 1245             


Leu Val  Thr Ala Ala Asp Ala  Val Thr Asn Ala Thr  Glu Leu Ala 
    1250                 1255                 1260             


Phe Ser  Leu Asp Glu Met Lys  Ile Ile Ser Thr Cys  Ala Lys Cys 
    1265                 1270                 1275             


Ile Asn  Gly Ala Asp Pro Ser  Ala Ile Asp Lys Ile  Gly Asn Ala 
    1280                 1285                 1290             


Gln Asp  Ser Phe Phe Asp Asn  Leu Lys Arg Arg Gly  Ser Asp Arg 
    1295                 1300                 1305             


Cys Ala  Leu Leu Phe Ser Gln  Leu Lys Leu Asp Lys  Leu Ser Gln 
    1310                 1315                 1320             


Asn Phe  Tyr Met Ile Ser Ser  Asp Asp Lys Ser Lys  Ile Leu Ile 
    1325                 1330                 1335             


Ser Ile  Leu Asp Arg Ile Arg  Ala Lys Ser Asn Ser  Val Asp Leu 
    1340                 1345                 1350             


Ser Leu  Val Gly Gly Ala Lys  His Ala Ala Gln Met  Lys Phe Asp 
    1355                 1360                 1365             


Phe Asn  Ala Lys Leu Asn Asn  Pro Ala Ser Ser Phe  Val Leu Ile 
    1370                 1375                 1380             


Asp Gln  Ser Val Thr Gly Met  Phe Glu Arg Arg Thr  Arg Ile Gly 
    1385                 1390                 1395             


Leu 
    


<210> 373
<211> 1535
<212> PRT
<213> Ornithobacterium rhinotracheale

<400> 373
Met Asn Thr Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Ile Lys Val Leu Asn Asp Lys Thr Arg Leu Pro Leu Glu Ile 
            20                  25                  30          


Ile Asp Leu Gly Val Val Val Ile Pro Thr Asp Gln Arg Thr Leu Asp 
        35                  40                  45              


Lys Phe Ser Lys Gly Glu Ser Ile Ser Lys Thr Ala Glu Arg Thr Lys 
    50                  55                  60                  


Gln Lys Gly Val Arg Lys Leu Tyr Glu Arg Lys Lys Leu Arg Arg Glu 
65                  70                  75                  80  


Arg Leu His Arg Val Leu Asn Ile Leu Gly Phe Leu Pro Glu His Tyr 
                85                  90                  95      


Ser Lys Lys Ile Asp Phe Lys Lys His Leu Gly Gln Phe Phe Gly Asn 
            100                 105                 110         


Ser Gln Pro Lys Ile Ser Tyr Val Glu Asn Asp His Gly Lys His Glu 
        115                 120                 125             


Phe Ile Phe Met Asp Ser Tyr Arg Glu Met Leu Lys Glu Phe Ser Lys 
    130                 135                 140                 


His Asn Ile Lys Asn Val Pro Tyr Asp Trp Thr Ile Tyr Tyr Leu Arg 
145                 150                 155                 160 


Lys Lys Ala Leu Ser Gln Lys Ile Ser Lys Glu Glu Leu Ala Trp Val 
                165                 170                 175     


Ile Leu Asn Phe Asn Lys Lys Arg Gly Tyr Tyr Gln Phe Arg Asp Asp 
            180                 185                 190         


Asn Ala Asp Glu Asn Lys Glu Asn Lys Ile Glu Lys Tyr Tyr Ala Leu 
        195                 200                 205             


Lys Val Thr Asn Val Lys Lys Glu Asp Ala Gln Asn Tyr Thr Ile Thr 
    210                 215                 220                 


Leu Glu Asn Gly Trp Ile Tyr Lys Asn Lys Ser Lys Ile Ser Leu Leu 
225                 230                 235                 240 


Asp Trp Val Gly Ser Thr Lys Glu Phe Ile Ser Thr Glu Lys Phe Asp 
                245                 250                 255     


Asn Lys Gly Asn Ile Ile Lys Lys Lys Asn Gly Glu Asp Asp Arg Thr 
            260                 265                 270         


Leu Lys Leu Val Asp Ser Glu Lys Asp Trp Ile Ala Ile Lys Lys Ser 
        275                 280                 285             


Thr Glu Asp Arg Ile Glu Asn Tyr Gly Lys Thr Val Gly Thr Tyr Leu 
    290                 295                 300                 


Tyr Glu His Leu Leu Lys Asp Pro Asn Gln Lys Leu Asn Gly Glu Leu 
305                 310                 315                 320 


Ile Asn Ile Ile Asp Arg Lys Phe Tyr Lys Asn Glu Leu Lys Gln Ile 
                325                 330                 335     


Leu Glu Lys Gln Lys Glu Phe His Pro Glu Leu Leu Asn Glu Asp Leu 
            340                 345                 350         


Phe Gln Lys Ser Ile Ile Glu Leu Tyr Pro Lys Asn Ser Thr Arg Gln 
        355                 360                 365             


Lys Glu Leu Lys Asn Lys Asp Leu Cys Tyr Leu Leu Ile Asp Asp Val 
    370                 375                 380                 


Ile Tyr Tyr Gln Arg Asp Leu Lys Lys Lys Asn Ser Thr Ile Asn Lys 
385                 390                 395                 400 


Cys Ser Phe Glu Ser Arg Glu Tyr Tyr Leu Asn Gly Glu Lys Gln Ile 
                405                 410                 415     


Gln Lys Ile Asn Cys Ile Ala Lys Ser Lys Pro Leu Tyr Gln Glu Phe 
            420                 425                 430         


Arg Thr Leu Gln Phe Ile Lys Asn Leu Lys Val Tyr Glu Ile Ile Asp 
        435                 440                 445             


Gly Leu Glu Lys Asp Ile Thr Ser Lys Leu Leu Pro Asp Phe Glu Thr 
    450                 455                 460                 


Lys Glu His Phe Phe Glu Trp Leu Asn Asp Lys Glu Lys Ile Asp Gln 
465                 470                 475                 480 


Leu Gln Leu Leu Ser Tyr Lys Cys Phe Asp Leu His Asp Asn Val Lys 
                485                 490                 495     


Asn Asp Leu Ile Ala Lys Gly Ile Lys Arg Pro Thr Glu Lys Ala Ile 
            500                 505                 510         


Arg Thr Glu Leu Leu Glu Lys Tyr Arg Trp Asn Tyr Ser Lys Asp Asn 
        515                 520                 525             


Asp Arg Asn Phe Leu Leu Asn Glu Thr Arg Phe Lys Ile Leu Lys Tyr 
    530                 535                 540                 


Leu Lys Lys Val Asp Lys Lys Leu Thr Leu Thr Asn Glu Gln Ile Glu 
545                 550                 555                 560 


Ser Leu Trp Leu Leu Leu Tyr Ser Ala Lys Asp Glu Arg Glu Leu Lys 
                565                 570                 575     


Asn Gly Leu Gln Lys Phe Ser Glu Lys Asn Lys Leu Pro Lys Lys Phe 
            580                 585                 590         


Ser Asp Ile Phe Ile Ser Phe Pro Pro Phe Lys Lys Glu Tyr Gly Ala 
        595                 600                 605             


Tyr Ser Glu Lys Ala Leu Lys Lys Leu Leu Ser Leu Val Arg Phe Gly 
    610                 615                 620                 


Lys Tyr Trp Ser Phe Asn Lys Ile Asp Asn Asn Ile Gln Asn Lys Ile 
625                 630                 635                 640 


Met Asn Ile Leu Asn Gly Glu Val Asp Asp Ser Ile Ser Asp Arg Val 
                645                 650                 655     


Arg Glu Lys Thr Ile Leu Leu Gln Asp Lys Asn Asp Phe Gln Asp Leu 
            660                 665                 670         


Pro Leu Trp Leu Ala Ser Tyr Val Ala Tyr Asn Arg Phe Ser Glu Val 
        675                 680                 685             


Ser Glu Ile Lys Tyr Trp Asp Ser Pro Asp Lys Ile Glu Phe Leu Lys 
    690                 695                 700                 


Gln His Ser Ile Gly Asn Pro Ile Val Glu Lys Ile Ile Asn Glu Thr 
705                 710                 715                 720 


Leu Lys Leu Ile Lys Asp Ile Trp Val Ile His Gly Lys Ser Cys Lys 
                725                 730                 735     


Asn Phe Phe Ser Glu Ile His Ile Glu Leu Ser Arg Glu Ile Lys Ser 
            740                 745                 750         


Ser Ser Lys Lys Arg Ala Gln Ile Thr Asn Asn Asn Thr Lys Asn Gln 
        755                 760                 765             


Lys Leu Asn Asn Leu Ile Lys Ser Leu Leu Ile Glu Met Ala Ser Asp 
    770                 775                 780                 


Thr Lys Tyr Glu Asn Val Thr Pro Tyr Ser Pro Ser Gln Gln Glu Ile 
785                 790                 795                 800 


Leu Lys Ile Tyr Asp Glu Gly Ile Tyr Ser Lys Glu Glu Asn Ser Glu 
                805                 810                 815     


Lys Ile Lys Glu Ile Asn Lys Ile Arg Asn Asn Asn Lys Ile Ser Lys 
            820                 825                 830         


Ser Asp Ile Thr Lys Tyr Lys Leu Trp Leu Glu Gln Gly Tyr Ile Ser 
        835                 840                 845             


Pro Tyr Thr Gly Lys Ile Ile Pro Leu Thr Lys Leu Phe Thr Ala Lys 
    850                 855                 860                 


Tyr Gln Lys Glu His Ile Ile Pro Gln Thr Lys Phe Phe Asp Asp Ser 
865                 870                 875                 880 


Phe Asn Asn Lys Val Ile Cys Glu Ala Glu Val Asn Lys Leu Lys Asp 
                885                 890                 895     


Asn Ser Leu Ala Met Asn Phe Ile Lys Ala Lys Gly Gly Lys Ala Val 
            900                 905                 910         


Lys Leu Ser Asp Gly Glu Thr Val Thr Ile Leu Asn Gln Glu Glu Tyr 
        915                 920                 925             


Lys Gln Leu Val Arg Thr Ser Phe Lys Lys Asn Ser Ile Lys Leu Arg 
    930                 935                 940                 


Asn Leu Leu Leu Glu Glu Ile Pro Asp Thr Phe Thr Lys Arg Gln Leu 
945                 950                 955                 960 


Asn Asp Thr Lys Tyr Ile Ser Lys Leu Val Leu Ser Leu Leu Ser Asn 
                965                 970                 975     


Ile Val Arg Glu Lys Gly Glu Leu Glu Ser Thr Ala Lys Arg Ile Val 
            980                 985                 990         


Ser Thr Asn Gly Gln Ile Thr Ser  Ile Leu Arg Asn Asp  Trp Gly Leu 
        995                 1000                 1005             


Asn Asn  Ile Trp Asn Lys Leu  Ile Thr Pro Arg Phe  Glu Arg Leu 
    1010                 1015                 1020             


Asn Asn  Ile Asn Lys Asn Lys  Ile Tyr Gly Asn Trp  Glu Asn Lys 
    1025                 1030                 1035             


Lys Gly  Lys Asn Val Phe Gln  Ile Asn Tyr Leu Asn  Asp Asn Leu 
    1040                 1045                 1050             


Ser Thr  Leu Asn Thr Lys Arg  Ile Asp His Arg His  His Ala Leu 
    1055                 1060                 1065             


Asp Ala  Leu Ile Val Ala Cys  Thr Thr Arg Asn His  Ile Asn Phe 
    1070                 1075                 1080             


Leu Asn  Asn Gln Tyr Ala Lys  Ser Arg Asn Gln Arg  His Asp Leu 
    1085                 1090                 1095             


Arg Ala  Lys Leu Lys Arg Arg  Glu Thr Ile Thr Thr  Glu Gly Ser 
    1100                 1105                 1110             


Lys Lys  Gln Val Phe Lys Asp  Phe Ile Lys Pro Trp  Glu Ser Phe 
    1115                 1120                 1125             


Thr Gln  Asp Ala Leu Lys Lys  Leu Glu Thr Thr Ile  Val Asn Phe 
    1130                 1135                 1140             


Lys Val  Asn Lys Arg Ile Ile  Asn Lys Thr Ile Asn  Trp Tyr Lys 
    1145                 1150                 1155             


Lys Trp  Glu Lys Gln Lys Asp  Gly Thr Tyr Lys Lys  Ile Gln Lys 
    1160                 1165                 1170             


Lys Gln  Thr Lys Gly Asp Ala  Trp Ala Ile Arg Lys  Pro Leu His 
    1175                 1180                 1185             


Ile Asp  Thr Ile Tyr Gly Ile  Val Cys Lys Lys Leu  Pro Leu Lys 
    1190                 1195                 1200             


Ser Ala  Leu Glu Asn Tyr Lys  Asn Ile Ile Asp Glu  Asn Leu Lys 
    1205                 1210                 1215             


His Lys  Ile Lys Glu Leu Lys  Glu Val Asn Lys Phe  Asp Asn Asn 
    1220                 1225                 1230             


Gln Ile  Ile Asn Phe Phe Lys  Glu Cys Asn Phe Ile  Phe Glu Asp 
    1235                 1240                 1245             


Asn Asn  Ile Gln Lys Val Glu  Val Tyr Asp Phe Lys  Asp Asn Arg 
    1250                 1255                 1260             


Asp Lys  Thr Ile Leu Ser Ser  Ser Arg Gln Leu Ile  Asp Glu Ser 
    1265                 1270                 1275             


Phe Thr  Pro Lys Lys Ile Gly  Lys Val Leu Asp Pro  Thr Ile Arg 
    1280                 1285                 1290             


Asn Ile  Leu Leu Lys His Leu  Asn Ser Thr Lys Tyr  Asn Asn Lys 
    1295                 1300                 1305             


Phe Asp  Ser Asp Gly Asn Pro  Ile Lys Pro Glu Lys  Leu Ala Phe 
    1310                 1315                 1320             


Ser Pro  Glu Gly Leu Lys Asp  Leu Asn Lys Asn Ile  Lys His Leu 
    1325                 1330                 1335             


Asn Asn  Asn Lys Glu His Gln  Pro Ile Lys Arg Val  Lys Leu Phe 
    1340                 1345                 1350             


Glu Thr  Leu Gly Asn Lys Ile  Lys Val Gly Tyr Thr  Gln Gln Lys 
    1355                 1360                 1365             


Asn Lys  Lys Phe Ala Glu Thr  Ala Thr Gly Thr Asn  Leu Phe Leu 
    1370                 1375                 1380             


Gly Ile  Tyr Ser Asp Asn Asn  Lys Arg Asp Phe Lys  Thr Ile Pro 
    1385                 1390                 1395             


Leu Ile  Leu Ala Ile Gln Arg  Glu Lys Glu Gly Leu  Asn Pro Cys 
    1400                 1405                 1410             


Pro Asp  Thr Asp Glu Lys Gly  Asn Gln Leu Leu Phe  Ser Leu Ser 
    1415                 1420                 1425             


Pro Asn  Glu Leu Val Phe Val  Pro Asn Asn Glu Glu  Arg Lys Asn 
    1430                 1435                 1440             


Pro Asn  Leu Val Asp Phe Glu  Asn Leu Ser Lys Asp  Gln Ile Asp 
    1445                 1450                 1455             


Arg Ile  Tyr Lys Phe Val Ser  Cys Thr Gly Ser Glu  Ala Tyr Phe 
    1460                 1465                 1470             


Val Pro  Ser Arg Thr Ala Lys  Pro Ile Ile Glu Asn  Glu Asn Gly 
    1475                 1480                 1485             


Thr Asn  Asn Lys Ser Gln Arg  Ile Ile Glu Phe Asn  Glu Lys Thr 
    1490                 1495                 1500             


Ser Ile  Lys Asn Glu Lys Asn  Glu Pro Val Leu Ile  Lys Thr Ile 
    1505                 1510                 1515             


Cys Trp  Lys Ile Glu Val Asn  Arg Leu Gly Lys Ile  Ile Lys Val 
    1520                 1525                 1530             


Ile Lys  
    1535 


<210> 374
<211> 1443
<212> PRT
<213> Parabacteroides johnsonii


<220>
<223> Parabacteroides johnsonii DSM 18315

<400> 374
Met Ile Lys Leu Leu Tyr Leu Glu Lys Leu Lys Gln Tyr Thr Met Lys 
1               5                   10                  15      


Lys Ile Leu Gly Leu Asp Leu Gly Thr Ser Ser Ile Gly Trp Ala Leu 
            20                  25                  30          


Val Asn Glu Ala Glu Asn Ser Asp Glu Val Ser Ser Ile Ile Lys Leu 
        35                  40                  45              


Gly Val Arg Val Asn Pro Leu Thr Val Asp Glu Met Gln Asn Phe Glu 
    50                  55                  60                  


Lys Gly Lys Ser Ile Thr Thr Asn Ala Asp Arg Thr Leu Lys Arg Ser 
65                  70                  75                  80  


Met Arg Arg Asn Leu Gln Arg Tyr Lys Leu Arg Arg Asp Ala Leu Ile 
                85                  90                  95      


Glu Leu Leu Lys Lys Val Gly Phe Ile Thr Asp Lys Thr Ile Leu Ser 
            100                 105                 110         


Glu Gln Gly Asn Arg Thr Thr Phe Glu Thr Tyr Arg Leu Arg Ala Lys 
        115                 120                 125             


Ala Ala Glu Glu Glu Ile Ser Leu Lys Glu Leu Ala Arg Val Leu Leu 
    130                 135                 140                 


Met Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala Lys Gly 
145                 150                 155                 160 


Glu Glu Glu Gly Ala Leu Ile Asp Gly Met Glu Ile Ala Lys Lys Leu 
                165                 170                 175     


Tyr Asp Glu Asp Leu Thr Pro Gly Gln Leu Cys Leu Gln Leu Leu Glu 
            180                 185                 190         


Ser Gly Lys Lys Phe Phe Pro Asp Phe Tyr Arg Ser Asp Leu Gln Glu 
        195                 200                 205             


Glu Phe Asn Lys Ile Trp Asp Phe Gln Lys Gln Phe Asn Leu Phe Ser 
    210                 215                 220                 


Phe Cys Asp Val Ala Lys Glu Glu Val Lys Gly Lys Asn Lys Ser Gln 
225                 230                 235                 240 


Thr Trp Ala Ile Leu Ala Lys Tyr Phe Val Glu Thr Lys Lys Val Asn 
                245                 250                 255     


Val Trp Asn Glu His Glu Ala Gln Thr Glu Asn Arg Glu Glu Val Tyr 
            260                 265                 270         


Lys Leu Val Gly Leu Lys Arg Thr Val Lys Gly Glu Glu Leu Lys Lys 
        275                 280                 285             


Glu Asn Tyr Arg Trp Arg Val Gln Ala Leu Thr Glu Gln Leu Asp Leu 
    290                 295                 300                 


Glu Lys Ile Ala Val Val Leu Gln Glu Ile Asn Gly Gln Ile Ser Ala 
305                 310                 315                 320 


Ser Ser Gly Tyr Leu Gly Ala Ile Ser Asp Arg Ser Lys Val Leu Tyr 
                325                 330                 335     


Phe Asn Arg Gln Thr Val Gly Gln Tyr Gln Met Ala Glu Leu Asn Lys 
            340                 345                 350         


Asn Pro Asn Met Ser Leu Arg Asn Met Val Phe Tyr Arg Gln Asp Tyr 
        355                 360                 365             


Leu Asp Glu Phe Asn Val Ile Trp Glu Lys Gln Ala Glu Phe His Lys 
    370                 375                 380                 


Glu Leu Thr Pro Glu Leu Lys Lys Glu Ile Arg Asp Ile Ile Ile Phe 
385                 390                 395                 400 


Tyr Gln Arg Arg Leu Lys Ser Gln Lys Gly Leu Ile Ser Phe Cys Glu 
                405                 410                 415     


Phe Glu Asn Arg Glu Val Val Val Glu Lys Glu Gly Lys Lys Gln Thr 
            420                 425                 430         


Lys Ile Ile Gly Cys Lys Val Ile Pro Arg Ser His Pro Leu Phe Gln 
        435                 440                 445             


Glu Phe Lys Ile Trp Gln Thr Leu Asn Asn Ile Glu Val Phe Val Gly 
    450                 455                 460                 


Glu Lys Lys Gly Lys Arg Lys Lys Ser Asn Val Ser Ser Asp Leu Phe 
465                 470                 475                 480 


Gly Asp Thr Glu Asp Ala Leu Ile Thr Glu Gly Arg Arg Phe Leu Tyr 
                485                 490                 495     


Gln Glu Glu Lys Lys Ile Leu Ala Lys Glu Leu Ser Ile Lys Lys Gly 
            500                 505                 510         


Leu Thr Lys Ala Glu Ile Leu Arg Leu Leu Phe Glu Asn Pro Gln Glu 
        515                 520                 525             


Leu Asp Ile Asn Phe Lys Gln Ile Asp Gly Asn Gln Thr Gly Phe Ala 
    530                 535                 540                 


Leu Phe Ser Ala Tyr Ser Asn Met Ile Glu Lys Tyr Gly Tyr Glu Pro 
545                 550                 555                 560 


Leu Asp Phe Lys Lys Pro Ala Glu Asp Leu Ile Ser Gln Leu Lys Thr 
                565                 570                 575     


Val Phe Thr Asp Leu Gly Trp Asn Thr Asp Leu Leu Phe Ile Asp Leu 
            580                 585                 590         


Asp Lys Glu Asn Lys Glu Trp Glu Lys Gln Pro Tyr Phe Arg Leu Trp 
        595                 600                 605             


His Leu Leu Tyr Ser Phe Glu Gly Asp Asn Thr Pro Thr Gly Asn Gly 
    610                 615                 620                 


Lys Leu Ile Glu Lys Ile Met Gln Leu Cys Gly Ile Glu Lys Glu Tyr 
625                 630                 635                 640 


Ala Ile Glu Leu Ala Asn Val Ser Leu Gln Asp Asp Tyr Gly Ser Leu 
                645                 650                 655     


Ser Ala Lys Ala Ile Lys Lys Ile Leu Leu Tyr Leu Lys Glu Gly Asn 
            660                 665                 670         


Gln Tyr Asp Met Ala Cys Glu Tyr Ala Gly Tyr Arg His Ser Lys Ser 
        675                 680                 685             


Ser Leu Thr Lys Glu Glu Ile Glu Asn Lys Val Leu Lys Asp Lys Leu 
    690                 695                 700                 


Glu Ile Leu Pro Lys Asn Ser Leu Arg Asn Pro Val Val Glu Lys Ile 
705                 710                 715                 720 


Leu Asn Gln Met Val Asn Val Ile Asn Thr Val Met Glu Val Tyr Gly 
                725                 730                 735     


Arg Pro Asp Glu Ile Arg Val Glu Leu Ala Arg Glu Leu Lys Lys Ser 
            740                 745                 750         


Ala Lys Glu Arg Glu Glu Leu Thr Lys Ala Val Ala Lys Asn Thr Arg 
        755                 760                 765             


Glu His Glu Glu Ile Arg Lys Val Leu Gln Ser Glu Phe Gly Met Ile 
    770                 775                 780                 


Asn Val Ser Arg Asn Asp Ile Ile Arg Tyr Lys Leu Tyr Glu Glu Leu 
785                 790                 795                 800 


Lys Asp Asn Gly Tyr Lys Thr Leu Tyr Ser Asn Gln Tyr Ile Pro Arg 
                805                 810                 815     


Glu Lys Leu Phe Ser Lys Glu Ile Asp Ile Glu His Ile Ile Pro Gln 
            820                 825                 830         


Ser Arg Leu Phe Asp Asp Ser Leu Ser Asn Lys Thr Leu Glu Tyr Lys 
        835                 840                 845             


Ser Ile Asn Ile Glu Lys Gly Asn Lys Thr Ala Tyr Asp Phe Val Lys 
    850                 855                 860                 


Glu Lys Tyr Gly Glu Glu Gly Leu Gln Gln Tyr Leu Asn Arg Cys Glu 
865                 870                 875                 880 


Asn Leu Cys Lys Asp Lys Lys Ala Lys Leu Arg Lys Leu Lys Met Glu 
                885                 890                 895     


Leu Asn Glu Ile Pro Asp Gly Phe Ile Asp Arg Asp Leu Arg Asn Thr 
            900                 905                 910         


Gln Tyr Ile Ala Lys Lys Ala Leu Ser Met Leu Thr Glu Ile Cys Arg 
        915                 920                 925             


Arg Val Val Ala Thr Thr Gly Ser Ile Thr Asp Lys Leu Arg Glu Asp 
    930                 935                 940                 


Trp Gln Leu Val Asp Val Met Lys Glu Leu Asn Leu Pro Lys Tyr Glu 
945                 950                 955                 960 


Ala Leu Gly Leu Val Glu Val Tyr Glu Asp Lys Asp Gly Arg Lys Ile 
                965                 970                 975     


Lys Arg Ile Lys Asp Trp Thr Lys Arg Asn Asp His Arg His His Ala 
            980                 985                 990         


Met Asp Ala Leu Thr Val Ala Phe  Thr Lys Asp Val Phe  Ile Gln Tyr 
        995                 1000                 1005             


Phe Asn  Asn Lys Asn Ala Ala  Trp Glu Ser Asp Ser  Lys Glu His 
    1010                 1015                 1020             


Thr Asn  Ile Val Gly Ile Lys  Thr Arg Tyr Phe Glu  Ser Gly Lys 
    1025                 1030                 1035             


Ala Val  Pro Pro Ile Pro Leu  Gly Gln Phe Arg Val  Glu Ala Lys 
    1040                 1045                 1050             


Cys His  Leu Glu Asn Leu Leu  Val Ser Ile Lys Ala  Lys Asn Lys 
    1055                 1060                 1065             


Val Val  Thr Thr Asn Val Asn  Cys Ile Lys Lys Lys  Gly Gly Thr 
    1070                 1075                 1080             


Tyr Lys  Asn Thr Gln Gln Thr  Pro Arg Gly Gln Leu  His Leu Glu 
    1085                 1090                 1095             


Thr Ile  Tyr Gly Ser His Asn  Gln Tyr Val Thr Lys  Ile Glu Lys 
    1100                 1105                 1110             


Val Asn  Ala Ser Phe Asp Ala  Val Lys Ile Ala Thr  Val Ser Lys 
    1115                 1120                 1125             


Gln Asp  Tyr Arg Asn Ala Leu  Leu Lys Arg Leu Glu  Val Phe Gly 
    1130                 1135                 1140             


Asn Asp  Pro Lys Lys Ala Phe  Thr Gly Lys Asn Ser  Leu Glu Lys 
    1145                 1150                 1155             


Asn Pro  Ile Tyr Leu Asp Arg  Ala Gln Thr Ile Gln  Val Pro Asp 
    1160                 1165                 1170             


Lys Val  Gln Thr Val Glu Leu  Glu Thr Ala Tyr Thr  Ile Arg Lys 
    1175                 1180                 1185             


Pro Val  Asp Pro Thr Leu Asn  Val Asp Lys Val Val  Asp Lys Lys 
    1190                 1195                 1200             


Ile Arg  Leu Ile Leu Glu Gln  Arg Leu Lys Glu Tyr  Gly Gly Asp 
    1205                 1210                 1215             


Ala Lys  Lys Ala Phe Val Asn  Leu Asp Glu Asn Pro  Ile Trp Leu 
    1220                 1225                 1230             


Asn Glu  Glu Lys Gly Ile Ser  Ile Lys Arg Val Thr  Ile Arg Gly 
    1235                 1240                 1245             


Ile Ser  Lys Ala Gln Ala Leu  His Asp Lys Lys Asp  Lys Asp Gly 
    1250                 1255                 1260             


Asn Phe  Ile Leu Asp Glu Thr  Gly Lys Arg Ile Pro  Val Asp Phe 
    1265                 1270                 1275             


Val Asn  Thr Gly Asn Asn His  His Val Ala Ile Tyr  Arg Lys Pro 
    1280                 1285                 1290             


Val Leu  Asp Lys Lys Gly Gln  Val Ile Phe Asp Asp  Glu Gly Asn 
    1295                 1300                 1305             


Pro Met  Tyr Glu Leu Asp Glu  Asp Val Val Pro Phe  Phe Glu Ala 
    1310                 1315                 1320             


Val Thr  Arg Ala Asn Leu Gly  Ile Pro Ile Ile Asp  Lys Asp Tyr 
    1325                 1330                 1335             


Lys Lys  Ser Glu Gly Trp Gln  Phe Leu Phe Ser Met  Lys Gln Asn 
    1340                 1345                 1350             


Glu Tyr  Phe Val Phe Pro Asn  Glu Lys Thr Gly Phe  Asn Pro Lys 
    1355                 1360                 1365             


Glu Val  Asp Leu Leu Asp Pro  Asp Asn Tyr Ala Met  Ile Ser Pro 
    1370                 1375                 1380             


Asn Leu  Phe Arg Val Gln Lys  Ile Gly Leu Asn Asp  Tyr Thr Phe 
    1385                 1390                 1395             


Arg His  His Leu Glu Thr Thr  Ile Gln Asn Asp Leu  Lys Phe Ile 
    1400                 1405                 1410             


Thr Trp  Ile Arg Cys Gly Lys  Ser Gly Ile Lys Asp  Ile Val Lys 
    1415                 1420                 1425             


Val Arg  Ile Asn His Ile Gly  Gln Ile Val Ser Val  Gly Glu Tyr 
    1430                 1435                 1440             


<210> 375
<211> 1424
<212> PRT
<213> Parabacteroides sp.


<220>
<223> Parabacteroides sp. D13

<400> 375
Met Lys Arg Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Asn Glu Ala Glu Thr Asp Glu Glu Val Ser Ser Ile Ile 
            20                  25                  30          


Arg Leu Gly Val Arg Val Asn Pro Leu Thr Val Asp Glu Thr Gln Asn 
        35                  40                  45              


Phe Glu Lys Gly Lys Ser Ile Thr Thr Asn Ala Glu Arg Thr Leu Lys 
    50                  55                  60                  


Arg Ser Met Arg Arg Asn Leu Gln Arg Tyr Lys Leu Arg Arg Asp Ala 
65                  70                  75                  80  


Leu Val Glu Phe Leu Lys Glu Leu Gly Phe Ile Thr Asp Glu Thr Ile 
                85                  90                  95      


Leu Ser Glu Gln Gly Asn Arg Thr Thr Phe Glu Thr Cys Arg Leu Arg 
            100                 105                 110         


Ala Lys Ala Ala Glu Glu Glu Ile Ser Leu Glu Glu Leu Ser Arg Val 
        115                 120                 125             


Leu Leu Met Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Val 
    130                 135                 140                 


Lys Lys Glu Glu Asp Gly Val Leu Ile Asp Gly Met Glu Ile Ala Lys 
145                 150                 155                 160 


Lys Leu Tyr Glu Glu Asp Leu Thr Pro Gly Gln Leu Cys Ser Gln Leu 
                165                 170                 175     


Leu Glu Ser Gly Lys Lys Val Leu Pro Asp Phe Tyr Arg Ser Asp Leu 
            180                 185                 190         


Gln Glu Glu Leu Asp Arg Ile Trp Ser Val Gln Lys Gln Phe His Pro 
        195                 200                 205             


Asp Val Phe Cys Asp Ala Ala Lys Glu Glu Ile Lys Gly Lys Asn Arg 
    210                 215                 220                 


Ser Gln Thr Trp Ala Ile Leu Ala Asn Tyr Phe Val Trp Lys Glu Glu 
225                 230                 235                 240 


Val Val Gly Trp Asn Asp Arg Glu Ala Lys Asn Glu Thr Ile Glu Lys 
                245                 250                 255     


Glu Cys Lys Leu Val Gly Leu Lys Arg Thr Thr Lys Gly Tyr Glu Leu 
            260                 265                 270         


Lys Lys Glu Asn Tyr Arg Trp Arg Ala Gln Ala Leu Thr Glu Gln Leu 
        275                 280                 285             


Gly Leu Glu Glu Ile Ala Val Val Leu Gln Glu Ile Asn Gly Gln Ile 
    290                 295                 300                 


Asn Ala Ser Ser Gly Tyr Leu Gly Ala Ile Ser Asp Arg Ser Lys Val 
305                 310                 315                 320 


Leu Tyr Phe Asn His Gln Thr Val Gly Gln Tyr Gln Met Ala Glu Leu 
                325                 330                 335     


Asp Lys Asn Pro His Ala Ser Leu Arg Asn Met Val Phe Tyr Arg Gln 
            340                 345                 350         


Asp Tyr Leu Asp Glu Phe Asp Arg Ile Trp Glu Lys Gln Ala Glu Phe 
        355                 360                 365             


His Lys Glu Leu Thr Ala Glu Leu Lys Lys Glu Ile Arg Asp Met Ile 
    370                 375                 380                 


Ile Phe Tyr Gln Arg Arg Leu Lys Ser Gln Lys Gly Leu Ile Ser Phe 
385                 390                 395                 400 


Cys Glu Phe Glu Arg Leu Glu Ile Val Val Glu Lys Asp Gly Lys Lys 
                405                 410                 415     


Gln Thr Lys Val Ile Gly Cys Lys Val Ile Pro Arg Ser His Pro Leu 
            420                 425                 430         


Phe Gln Glu Phe Lys Val Trp Gln Thr Leu Asn Asp Ile Lys Val Leu 
        435                 440                 445             


Gly Arg Glu Lys Lys Arg Asn Ala Leu Ser Ala Ser Glu Ser Arg Ala 
    450                 455                 460                 


Leu Tyr Pro Glu Glu Lys Glu Ile Leu Ala Arg Glu Leu Ala Ile Lys 
465                 470                 475                 480 


Glu Asn Met Lys Lys Ala Asp Val Leu Lys Leu Leu Phe Glu Asn Pro 
                485                 490                 495     


Gln Glu Leu Asp Leu Asn Phe Lys Gln Ile Asp Gly Asn Arg Thr Gly 
            500                 505                 510         


Phe Ser Leu Phe Ser Ala Tyr Ser Lys Met Ile Glu Lys Tyr Gly Tyr 
        515                 520                 525             


Glu Pro Leu Asp Phe Lys Lys Pro Ala Asp Glu Ile Ile Gly Gln Leu 
    530                 535                 540                 


Arg Thr Ile Phe Thr Asp Leu Gly Trp Asn Thr Asn Leu Phe Thr Ile 
545                 550                 555                 560 


Asp Leu Thr Lys Glu Gly Lys Glu Leu Glu Met Gln Pro Tyr Phe Arg 
                565                 570                 575     


Leu Trp His Leu Leu Tyr Ser Phe Glu Gly Asp Asn Thr Ser Thr Gly 
            580                 585                 590         


Asn Gly Lys Leu Ile Glu Lys Ile Met Gln Leu Cys Gly Val Glu Lys 
        595                 600                 605             


Glu Tyr Ala Val Glu Leu Ala Ser Leu Ser Phe Gln Asp Asp Tyr Gly 
    610                 615                 620                 


Ser Leu Ser Ala Lys Ala Ile Lys Arg Ile Leu Pro Tyr Leu Lys Glu 
625                 630                 635                 640 


Gly Asn Leu Tyr Asp Val Ala Cys Glu Tyr Ala Gly Tyr Arg His Ser 
                645                 650                 655     


Lys Ser Ser Leu Thr Lys Glu Glu Ile Glu Asn Lys Val Leu Lys Gly 
            660                 665                 670         


Lys Leu Glu Val Leu Pro Lys Asn Ser Leu Arg Asn Pro Val Val Glu 
        675                 680                 685             


Lys Ile Leu Ser Gln Met Val Asn Val Ile Asn Thr Ile Ile Asp Thr 
    690                 695                 700                 


Tyr Gly Lys Pro Asp Glu Ile Arg Val Glu Leu Ala Arg Glu Leu Lys 
705                 710                 715                 720 


Lys Ser Ala Lys Glu Arg Glu Glu Leu Thr Lys Ala Ile Ala Lys Ser 
                725                 730                 735     


Thr Arg Glu His Glu Glu Ile Arg Lys Leu Leu Gln Asp Glu Phe Gly 
            740                 745                 750         


Met Met Asn Val Ser Arg Asn Asp Ile Ile Arg Tyr Lys Leu Tyr Glu 
        755                 760                 765             


Glu Leu Lys Asp Asn Gly Tyr Lys Thr Leu Tyr Ser Asn Gln Tyr Ile 
    770                 775                 780                 


Pro Lys Glu Lys Ile Phe Ser Lys Glu Ile Asp Ile Glu His Ile Ile 
785                 790                 795                 800 


Pro Gln Ser Arg Leu Phe Asp Asp Ser Leu Ser Asn Lys Thr Leu Glu 
                805                 810                 815     


Tyr Lys Ala Ile Asn Ile Glu Lys Gly Asn Lys Thr Ala Tyr Asp Phe 
            820                 825                 830         


Val Lys Glu Lys Tyr Gly Glu Glu Gly Leu Gln Gln Tyr Ile Asn Arg 
        835                 840                 845             


Cys Glu Ser Leu Phe Asn Asp Lys Lys Ala Lys Leu Arg Lys Leu Lys 
    850                 855                 860                 


Met Glu Gln Lys Asp Ile Pro Asp Gly Phe Ile Asp Arg Asp Leu Arg 
865                 870                 875                 880 


Asn Thr Gln Tyr Ile Ala Lys Lys Ala Leu Ala Met Leu Asn Glu Ile 
                885                 890                 895     


Cys Arg Arg Val Val Ala Thr Thr Gly Ser Ile Thr Asp Gln Leu Arg 
            900                 905                 910         


Glu Asp Trp Gln Leu Val Asp Val Met Lys Glu Leu Asn Leu Pro Lys 
        915                 920                 925             


Tyr Glu Ala Leu Gly Phe Val Glu Thr Tyr Glu Asp Lys Asp Gly Arg 
    930                 935                 940                 


Lys Ile Lys Arg Ile Lys Asp Trp Thr Lys Arg Asn Asp His Arg His 
945                 950                 955                 960 


His Ala Met Asp Ala Leu Thr Val Ala Phe Thr Lys Asp Ala Phe Ile 
                965                 970                 975     


Gln Tyr Phe Asn Asn Lys Asn Ala Ala Gln Asp Ser Gly Asn Arg Asn 
            980                 985                 990         


His Thr Asn Ile Ile Gly Ile Lys  Thr Arg Tyr Phe Asp  Lys Gly Arg 
        995                 1000                 1005             


Ala Leu  Pro Pro Ile Pro Leu  Glu Gln Phe Arg Ile  Glu Ala Lys 
    1010                 1015                 1020             


Gln His  Leu Glu Lys Leu Leu  Val Ser Ile Lys Ala  Lys Asn Lys 
    1025                 1030                 1035             


Val Val  Thr Val Asn Val Asn  Arg Thr Lys Lys Arg  Lys Gly Glu 
    1040                 1045                 1050             


Asn Thr  Lys Ile Gln Gln Thr  Pro Arg Gly Gln Leu  His Leu Glu 
    1055                 1060                 1065             


Thr Val  Tyr Gly Ser His Lys  Gln Tyr Val Thr Lys  Ile Glu Lys 
    1070                 1075                 1080             


Val Asn  Ala Ser Phe Asp Ala  Ala Lys Ile Ala Thr  Val Ser Lys 
    1085                 1090                 1095             


Arg Ala  Tyr Arg Asn Ala Leu  Leu Lys Arg Leu Glu  Thr Phe Gly 
    1100                 1105                 1110             


Asn Asp  Pro Lys Lys Ala Phe  Thr Gly Lys Asn Ala  Leu Glu Lys 
    1115                 1120                 1125             


Asn Pro  Leu Tyr Ala Asp Lys  Tyr Gln Thr Ile Arg  Val Pro Glu 
    1130                 1135                 1140             


Lys Val  Gln Thr Val Glu Phe  Glu Thr Ile Tyr Thr  Ile Arg Lys 
    1145                 1150                 1155             


Pro Val  Asp Pro Ala Leu Asn  Val Asp Lys Val Val  Asp Val Lys 
    1160                 1165                 1170             


Val Arg  Ala Ile Leu Glu Arg  Arg Leu Lys Glu Tyr  Gly Gly Asp 
    1175                 1180                 1185             


Pro Lys  Lys Ala Phe Val Asn  Phe Trp Glu Asn Pro  Ile Trp Leu 
    1190                 1195                 1200             


Asn Lys  Glu Lys Gly Ile Ser  Ile Lys Arg Val Ser  Ile Arg Gly 
    1205                 1210                 1215             


Ile Asn  Asn Ala Gln Ser Ile  His Val Lys Lys Asp  Lys Asn Gly 
    1220                 1225                 1230             


Asn Pro  Ile Trp Asp Glu Asn  Gly Lys Gln Ile Pro  Val Asp Phe 
    1235                 1240                 1245             


Val Asn  Thr Gly Asn Asn His  His Val Ala Ile Tyr  Arg Lys Pro 
    1250                 1255                 1260             


Val Leu  Asp Lys Lys Gly Gln  Val Thr Phe Asp Glu  Asp Gly Asn 
    1265                 1270                 1275             


Leu Met  Tyr Glu Leu Asp Glu  Val Val Val Pro Phe  Phe Glu Ala 
    1280                 1285                 1290             


Val Thr  Arg Ala Asn Leu Gly  Leu Pro Ile Ile Asp  Lys Asp Tyr 
    1295                 1300                 1305             


Arg Lys  Ser Glu Gly Trp Gln  Phe Leu Phe Ser Met  Lys Gln Asn 
    1310                 1315                 1320             


Glu Tyr  Phe Val Phe Pro Asn  Glu Lys Thr Gly Phe  Asn Pro Lys 
    1325                 1330                 1335             


Glu Val  Asp Leu Leu Asn Pro  Asp Asn Tyr Ala Met  Ile Ser Pro 
    1340                 1345                 1350             


Asn Leu  Phe Arg Val Gln Thr  Met Ser Lys Val Met  Tyr Gly Asn 
    1355                 1360                 1365             


Asn Val  Val Arg Asp Tyr Lys  Phe Arg His His Leu  Glu Thr Thr 
    1370                 1375                 1380             


Val Lys  Asp Met Lys Glu Leu  Lys Asp Ile Ala Tyr  Lys Gln Tyr 
    1385                 1390                 1395             


Lys Thr  Leu Ser Phe Gly Asn  Ser Val Val Lys Ile  Arg Ile Asn 
    1400                 1405                 1410             


His Ile  Gly Gln Ile Val Ser  Val Gly Glu Tyr 
    1415                 1420                 


<210> 376
<211> 1428
<212> PRT
<213> Parasutterella excrementihominis


<220>
<223> Parasutterella excrementihominis YIT 11859

<400> 376
Met Gly Lys Thr His Ile Ile Gly Val Gly Leu Asp Leu Gly Gly Thr 
1               5                   10                  15      


Tyr Thr Gly Thr Phe Ile Thr Ser His Pro Ser Asp Glu Ala Glu His 
            20                  25                  30          


Arg Asp His Ser Ser Ala Phe Thr Val Val Asn Ser Glu Lys Leu Ser 
        35                  40                  45              


Phe Ser Ser Lys Ser Arg Thr Ala Val Arg His Arg Val Arg Ser Tyr 
    50                  55                  60                  


Lys Gly Phe Asp Leu Arg Arg Arg Leu Leu Leu Leu Val Ala Glu Tyr 
65                  70                  75                  80  


Gln Leu Leu Gln Lys Lys Gln Thr Leu Ala Pro Glu Glu Arg Glu Asn 
                85                  90                  95      


Leu Arg Ile Ala Leu Ser Gly Tyr Leu Lys Arg Arg Gly Tyr Ala Arg 
            100                 105                 110         


Thr Glu Ala Glu Thr Asp Thr Ser Val Leu Glu Ser Leu Asp Pro Ser 
        115                 120                 125             


Val Phe Ser Ser Ala Pro Ser Phe Thr Asn Phe Phe Asn Asp Ser Glu 
    130                 135                 140                 


Pro Leu Asn Ile Gln Trp Glu Ala Ile Ala Asn Ser Pro Glu Thr Thr 
145                 150                 155                 160 


Lys Ala Leu Asn Lys Glu Leu Ser Gly Gln Lys Glu Ala Asp Phe Lys 
                165                 170                 175     


Lys Tyr Ile Lys Thr Ser Phe Pro Glu Tyr Ser Ala Lys Glu Ile Leu 
            180                 185                 190         


Ala Asn Tyr Val Glu Gly Arg Arg Ala Ile Leu Asp Ala Ser Lys Tyr 
        195                 200                 205             


Ile Ala Asn Leu Gln Ser Leu Gly His Lys His Arg Ser Lys Tyr Leu 
    210                 215                 220                 


Ser Asp Ile Leu Gln Asp Met Lys Arg Asp Ser Arg Ile Thr Arg Leu 
225                 230                 235                 240 


Ser Glu Ala Phe Gly Ser Thr Asp Asn Leu Trp Arg Ile Ile Gly Asn 
                245                 250                 255     


Ile Ser Asn Leu Gln Glu Arg Ala Val Arg Trp Tyr Phe Asn Asp Ala 
            260                 265                 270         


Lys Phe Glu Gln Gly Gln Glu Gln Leu Asp Ala Val Lys Leu Lys Asn 
        275                 280                 285             


Val Leu Val Arg Ala Leu Lys Tyr Leu Arg Ser Asp Asp Lys Glu Trp 
    290                 295                 300                 


Ser Ala Ser Gln Lys Gln Ile Ile Gln Ser Leu Glu Gln Ser Gly Asp 
305                 310                 315                 320 


Val Leu Asp Val Leu Ala Gly Leu Asp Pro Asp Arg Thr Ile Pro Pro 
                325                 330                 335     


Tyr Glu Asp Gln Asn Asn Arg Arg Pro Pro Glu Asp Gln Thr Leu Tyr 
            340                 345                 350         


Leu Asn Pro Lys Ala Leu Ser Ser Glu Tyr Gly Glu Lys Trp Lys Ser 
        355                 360                 365             


Trp Ala Asn Lys Phe Ala Gly Ala Tyr Pro Leu Leu Thr Glu Asp Leu 
    370                 375                 380                 


Thr Glu Ile Leu Lys Asn Thr Asp Arg Lys Ser Arg Ile Lys Ile Arg 
385                 390                 395                 400 


Ser Asp Val Leu Pro Asp Ser Asp Tyr Arg Leu Ala Tyr Ile Leu Gln 
                405                 410                 415     


Arg Ala Phe Asp Arg Ser Ile Ala Leu Asp Glu Cys Ser Ile Arg Arg 
            420                 425                 430         


Thr Ala Glu Asp Phe Glu Asn Gly Val Val Ile Lys Asn Glu Lys Leu 
        435                 440                 445             


Glu Asp Val Leu Ser Gly His Gln Leu Glu Glu Phe Leu Glu Phe Ala 
    450                 455                 460                 


Asn Arg Tyr Tyr Gln Glu Thr Ala Lys Ala Lys Asn Gly Leu Trp Phe 
465                 470                 475                 480 


Pro Glu Asn Ala Leu Leu Glu Arg Ala Asp Leu His Pro Pro Met Lys 
                485                 490                 495     


Asn Lys Ile Leu Asn Val Ile Val Gly Gln Ala Leu Gly Val Ser Pro 
            500                 505                 510         


Ala Glu Gly Thr Asp Phe Ile Glu Glu Ile Trp Asn Ser Lys Val Lys 
        515                 520                 525             


Gly Arg Ser Thr Val Arg Ser Ile Cys Asn Ala Ile Glu Asn Glu Arg 
    530                 535                 540                 


Lys Thr Tyr Gly Pro Tyr Phe Ser Glu Asp Tyr Lys Phe Val Lys Thr 
545                 550                 555                 560 


Ala Leu Lys Glu Gly Lys Thr Glu Lys Glu Leu Ser Lys Lys Phe Ala 
                565                 570                 575     


Ala Val Ile Lys Val Leu Lys Met Val Ser Glu Val Val Pro Phe Ile 
            580                 585                 590         


Gly Lys Glu Leu Arg Leu Ser Asp Glu Ala Gln Ser Lys Phe Asp Asn 
        595                 600                 605             


Leu Tyr Ser Leu Ala Gln Leu Tyr Asn Leu Ile Glu Thr Glu Arg Asn 
    610                 615                 620                 


Gly Phe Ser Lys Val Ser Leu Ala Ala His Leu Glu Asn Ala Trp Arg 
625                 630                 635                 640 


Met Thr Met Thr Asp Gly Ser Ala Gln Cys Cys Arg Leu Pro Ala Asp 
                645                 650                 655     


Cys Val Arg Pro Phe Asp Gly Phe Ile Arg Lys Ala Ile Asp Arg Asn 
            660                 665                 670         


Ser Trp Glu Val Ala Lys Arg Ile Ala Glu Glu Val Lys Lys Ser Val 
        675                 680                 685             


Asp Phe Thr Asn Gly Thr Val Lys Ile Pro Val Ala Ile Glu Ala Asn 
    690                 695                 700                 


Ser Phe Asn Phe Thr Ala Ser Leu Thr Asp Leu Lys Tyr Ile Gln Leu 
705                 710                 715                 720 


Lys Glu Gln Lys Leu Lys Lys Lys Leu Glu Asp Ile Gln Arg Asn Glu 
                725                 730                 735     


Glu Asn Gln Glu Lys Arg Trp Leu Ser Lys Glu Glu Arg Ile Arg Ala 
            740                 745                 750         


Asp Ser His Gly Ile Cys Ala Tyr Thr Gly Arg Pro Leu Asp Asp Val 
        755                 760                 765             


Gly Glu Ile Asp His Ile Ile Pro Arg Ser Leu Thr Leu Lys Lys Ser 
    770                 775                 780                 


Glu Ser Ile Tyr Asn Ser Glu Val Asn Leu Ile Phe Val Ser Ala Gln 
785                 790                 795                 800 


Gly Asn Gln Glu Lys Lys Asn Asn Ile Tyr Leu Leu Ser Asn Leu Ala 
                805                 810                 815     


Lys Asn Tyr Leu Ala Ala Val Phe Gly Thr Ser Asp Leu Ser Gln Ile 
            820                 825                 830         


Thr Asn Glu Ile Glu Ser Thr Val Leu Gln Leu Lys Ala Ala Gly Arg 
        835                 840                 845             


Leu Gly Tyr Phe Asp Leu Leu Ser Glu Lys Glu Arg Ala Cys Ala Arg 
    850                 855                 860                 


His Ala Leu Phe Leu Asn Ser Asp Ser Glu Ala Arg Arg Ala Val Ile 
865                 870                 875                 880 


Asp Val Leu Gly Ser Arg Arg Lys Ala Ser Val Asn Gly Thr Gln Ala 
                885                 890                 895     


Trp Phe Val Arg Ser Ile Phe Ser Lys Val Arg Gln Ala Leu Ala Ala 
            900                 905                 910         


Trp Thr Gln Glu Thr Gly Asn Glu Leu Ile Phe Asp Ala Ile Ser Val 
        915                 920                 925             


Pro Ala Ala Asp Ser Ser Glu Met Arg Lys Arg Phe Ala Glu Tyr Arg 
    930                 935                 940                 


Pro Glu Phe Arg Lys Pro Lys Val Gln Pro Val Ala Ser His Ser Ile 
945                 950                 955                 960 


Asp Ala Met Cys Ile Tyr Leu Ala Ala Cys Ser Asp Pro Phe Lys Thr 
                965                 970                 975     


Lys Arg Met Gly Ser Gln Leu Ala Ile Tyr Glu Pro Ile Asn Phe Asp 
            980                 985                 990         


Asn Leu Phe Thr Gly Ser Cys Gln  Val Ile Gln Asn Thr  Pro Arg Asn 
        995                 1000                 1005             


Phe Ser  Asp Lys Thr Asn Ile  Ala Asn Ser Pro Ile  Phe Lys Glu 
    1010                 1015                 1020             


Thr Ile  Tyr Ala Glu Arg Phe  Leu Asp Ile Ile Val  Ser Arg Gly 
    1025                 1030                 1035             


Glu Ile  Phe Ile Gly Tyr Pro  Ser Asn Met Pro Phe  Glu Glu Lys 
    1040                 1045                 1050             


Pro Asn  Arg Ile Ser Ile Gly  Gly Lys Asp Pro Phe  Ser Ile Leu 
    1055                 1060                 1065             


Ser Val  Leu Gly Ala Tyr Leu  Asp Lys Ala Pro Ser  Ser Glu Lys 
    1070                 1075                 1080             


Glu Lys  Leu Thr Ile Tyr Arg  Val Val Lys Asn Lys  Ala Phe Glu 
    1085                 1090                 1095             


Leu Phe  Ser Lys Val Ala Gly  Ser Lys Phe Thr Ala  Glu Glu Asp 
    1100                 1105                 1110             


Lys Ala  Ala Lys Ile Leu Glu  Ala Leu His Phe Val  Thr Val Lys 
    1115                 1120                 1125             


Gln Asp  Val Ala Ala Thr Val  Ser Asp Leu Ile Lys  Ser Lys Lys 
    1130                 1135                 1140             


Glu Leu  Ser Lys Asp Ser Ile  Glu Asn Leu Ala Lys  Gln Lys Gly 
    1145                 1150                 1155             


Cys Leu  Lys Lys Val Glu Tyr  Ser Ser Lys Glu Phe  Lys Phe Lys 
    1160                 1165                 1170             


Gly Ser  Leu Ile Ile Pro Ala  Ala Val Glu Trp Gly  Lys Val Leu 
    1175                 1180                 1185             


Trp Asn  Val Phe Lys Glu Asn  Thr Ala Glu Glu Leu  Lys Asp Glu 
    1190                 1195                 1200             


Asn Ala  Leu Arg Lys Ala Leu  Glu Ala Ala Trp Pro  Ser Ser Phe 
    1205                 1210                 1215             


Gly Thr  Arg Asn Leu His Ser  Lys Ala Lys Arg Val  Phe Ser Leu 
    1220                 1225                 1230             


Pro Val  Val Ala Thr Gln Ser  Gly Ala Val Arg Ile  Arg Arg Lys 
    1235                 1240                 1245             


Thr Ala  Phe Gly Asp Phe Val  Tyr Gln Ser Gln Asp  Thr Asn Asn 
    1250                 1255                 1260             


Leu Tyr  Ser Ser Phe Pro Val  Lys Asn Gly Lys Leu  Asp Trp Ser 
    1265                 1270                 1275             


Ser Pro  Ile Ile His Pro Ala  Leu Gln Asn Arg Asn  Leu Thr Ala 
    1280                 1285                 1290             


Tyr Gly  Tyr Arg Phe Val Asp  His Asp Arg Ser Ile  Ser Met Ser 
    1295                 1300                 1305             


Glu Phe  Arg Glu Val Tyr Asn  Lys Asp Asp Leu Met  Arg Ile Glu 
    1310                 1315                 1320             


Leu Ala  Gln Gly Thr Ser Ser  Arg Arg Tyr Leu Arg  Val Glu Met 
    1325                 1330                 1335             


Pro Gly  Glu Lys Phe Leu Ala  Trp Phe Gly Glu Asn  Ser Ile Ser 
    1340                 1345                 1350             


Leu Gly  Ser Ser Phe Lys Phe  Ser Val Ser Glu Val  Phe Asp Asn 
    1355                 1360                 1365             


Lys Ile  Tyr Thr Glu Asn Ala  Glu Phe Thr Lys Phe  Leu Pro Lys 
    1370                 1375                 1380             


Pro Arg  Glu Asp Asn Lys His  Asn Gly Thr Ile Phe  Phe Glu Leu 
    1385                 1390                 1395             


Val Gly  Pro Arg Val Ile Phe  Asn Tyr Ile Val Gly  Gly Ala Ala 
    1400                 1405                 1410             


Ser Ser  Leu Lys Glu Ile Phe  Ser Glu Ala Gly Lys  Glu Arg Ser 
    1415                 1420                 1425             


<210> 377
<211> 1037
<212> PRT
<213> Parvibaculum lavamentivorans

<400> 377
Met Glu Arg Ile Phe Gly Phe Asp Ile Gly Thr Thr Ser Ile Gly Phe 
1               5                   10                  15      


Ser Val Ile Asp Tyr Ser Ser Thr Gln Ser Ala Gly Asn Ile Gln Arg 
            20                  25                  30          


Leu Gly Val Arg Ile Phe Pro Glu Ala Arg Asp Pro Asp Gly Thr Pro 
        35                  40                  45              


Leu Asn Gln Gln Arg Arg Gln Lys Arg Met Met Arg Arg Gln Leu Arg 
    50                  55                  60                  


Arg Arg Arg Ile Arg Arg Lys Ala Leu Asn Glu Thr Leu His Glu Ala 
65                  70                  75                  80  


Gly Phe Leu Pro Ala Tyr Gly Ser Ala Asp Trp Pro Val Val Met Ala 
                85                  90                  95      


Asp Glu Pro Tyr Glu Leu Arg Arg Arg Gly Leu Glu Glu Gly Leu Ser 
            100                 105                 110         


Ala Tyr Glu Phe Gly Arg Ala Ile Tyr His Leu Ala Gln His Arg His 
        115                 120                 125             


Phe Lys Gly Arg Glu Leu Glu Glu Ser Asp Thr Pro Asp Pro Asp Val 
    130                 135                 140                 


Asp Asp Glu Lys Glu Ala Ala Asn Glu Arg Ala Ala Thr Leu Lys Ala 
145                 150                 155                 160 


Leu Lys Asn Glu Gln Thr Thr Leu Gly Ala Trp Leu Ala Arg Arg Pro 
                165                 170                 175     


Pro Ser Asp Arg Lys Arg Gly Ile His Ala His Arg Asn Val Val Ala 
            180                 185                 190         


Glu Glu Phe Glu Arg Leu Trp Glu Val Gln Ser Lys Phe His Pro Ala 
        195                 200                 205             


Leu Lys Ser Glu Glu Met Arg Ala Arg Ile Ser Asp Thr Ile Phe Ala 
    210                 215                 220                 


Gln Arg Pro Val Phe Trp Arg Lys Asn Thr Leu Gly Glu Cys Arg Phe 
225                 230                 235                 240 


Met Pro Gly Glu Pro Leu Cys Pro Lys Gly Ser Trp Leu Ser Gln Gln 
                245                 250                 255     


Arg Arg Met Leu Glu Lys Leu Asn Asn Leu Ala Ile Ala Gly Gly Asn 
            260                 265                 270         


Ala Arg Pro Leu Asp Ala Glu Glu Arg Asp Ala Ile Leu Ser Lys Leu 
        275                 280                 285             


Gln Gln Gln Ala Ser Met Ser Trp Pro Gly Val Arg Ser Ala Leu Lys 
    290                 295                 300                 


Ala Leu Tyr Lys Gln Arg Gly Glu Pro Gly Ala Glu Lys Ser Leu Lys 
305                 310                 315                 320 


Phe Asn Leu Glu Leu Gly Gly Glu Ser Lys Leu Leu Gly Asn Ala Leu 
                325                 330                 335     


Glu Ala Lys Leu Ala Asp Met Phe Gly Pro Asp Trp Pro Ala His Pro 
            340                 345                 350         


Arg Lys Gln Glu Ile Arg His Ala Val His Glu Arg Leu Trp Ala Ala 
        355                 360                 365             


Asp Tyr Gly Glu Thr Pro Asp Lys Lys Arg Val Ile Ile Leu Ser Glu 
    370                 375                 380                 


Lys Asp Arg Lys Ala His Arg Glu Ala Ala Ala Asn Ser Phe Val Ala 
385                 390                 395                 400 


Asp Phe Gly Ile Thr Gly Glu Gln Ala Ala Gln Leu Gln Ala Leu Lys 
                405                 410                 415     


Leu Pro Thr Gly Trp Glu Pro Tyr Ser Ile Pro Ala Leu Asn Leu Phe 
            420                 425                 430         


Leu Ala Glu Leu Glu Lys Gly Glu Arg Phe Gly Ala Leu Val Asn Gly 
        435                 440                 445             


Pro Asp Trp Glu Gly Trp Arg Arg Thr Asn Phe Pro His Arg Asn Gln 
    450                 455                 460                 


Pro Thr Gly Glu Ile Leu Asp Lys Leu Pro Ser Pro Ala Ser Lys Glu 
465                 470                 475                 480 


Glu Arg Glu Arg Ile Ser Gln Leu Arg Asn Pro Thr Val Val Arg Thr 
                485                 490                 495     


Gln Asn Glu Leu Arg Lys Val Val Asn Asn Leu Ile Gly Leu Tyr Gly 
            500                 505                 510         


Lys Pro Asp Arg Ile Arg Ile Glu Val Gly Arg Asp Val Gly Lys Ser 
        515                 520                 525             


Lys Arg Glu Arg Glu Glu Ile Gln Ser Gly Ile Arg Arg Asn Glu Lys 
    530                 535                 540                 


Gln Arg Lys Lys Ala Thr Glu Asp Leu Ile Lys Asn Gly Ile Ala Asn 
545                 550                 555                 560 


Pro Ser Arg Asp Asp Val Glu Lys Trp Ile Leu Trp Lys Glu Gly Gln 
                565                 570                 575     


Glu Arg Cys Pro Tyr Thr Gly Asp Gln Ile Gly Phe Asn Ala Leu Phe 
            580                 585                 590         


Arg Glu Gly Arg Tyr Glu Val Glu His Ile Trp Pro Arg Ser Arg Ser 
        595                 600                 605             


Phe Asp Asn Ser Pro Arg Asn Lys Thr Leu Cys Arg Lys Asp Val Asn 
    610                 615                 620                 


Ile Glu Lys Gly Asn Arg Met Pro Phe Glu Ala Phe Gly His Asp Glu 
625                 630                 635                 640 


Asp Arg Trp Ser Ala Ile Gln Ile Arg Leu Gln Gly Met Val Ser Ala 
                645                 650                 655     


Lys Gly Gly Thr Gly Met Ser Pro Gly Lys Val Lys Arg Phe Leu Ala 
            660                 665                 670         


Lys Thr Met Pro Glu Asp Phe Ala Ala Arg Gln Leu Asn Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ala Lys Gln Ile Leu Ala Gln Leu Lys Arg Leu Trp Pro Asp 
    690                 695                 700                 


Met Gly Pro Glu Ala Pro Val Lys Val Glu Ala Val Thr Gly Gln Val 
705                 710                 715                 720 


Thr Ala Gln Leu Arg Lys Leu Trp Thr Leu Asn Asn Ile Leu Ala Asp 
                725                 730                 735     


Asp Gly Glu Lys Thr Arg Ala Asp His Arg His His Ala Ile Asp Ala 
            740                 745                 750         


Leu Thr Val Ala Cys Thr His Pro Gly Met Thr Asn Lys Leu Ser Arg 
        755                 760                 765             


Tyr Trp Gln Leu Arg Asp Asp Pro Arg Ala Glu Lys Pro Ala Leu Thr 
    770                 775                 780                 


Pro Pro Trp Asp Thr Ile Arg Ala Asp Ala Glu Lys Ala Val Ser Glu 
785                 790                 795                 800 


Ile Val Val Ser His Arg Val Arg Lys Lys Val Ser Gly Pro Leu His 
                805                 810                 815     


Lys Glu Thr Thr Tyr Gly Asp Thr Gly Thr Asp Ile Lys Thr Lys Ser 
            820                 825                 830         


Gly Thr Tyr Arg Gln Phe Val Thr Arg Lys Lys Ile Glu Ser Leu Ser 
        835                 840                 845             


Lys Gly Glu Leu Asp Glu Ile Arg Asp Pro Arg Ile Lys Glu Ile Val 
    850                 855                 860                 


Ala Ala His Val Ala Gly Arg Gly Gly Asp Pro Lys Lys Ala Phe Pro 
865                 870                 875                 880 


Pro Tyr Pro Cys Val Ser Pro Gly Gly Pro Glu Ile Arg Lys Val Arg 
                885                 890                 895     


Leu Thr Ser Lys Gln Gln Leu Asn Leu Met Ala Gln Thr Gly Asn Gly 
            900                 905                 910         


Tyr Ala Asp Leu Gly Ser Asn His His Ile Ala Ile Tyr Arg Leu Pro 
        915                 920                 925             


Asp Gly Lys Ala Asp Phe Glu Ile Val Ser Leu Phe Asp Ala Ser Arg 
    930                 935                 940                 


Arg Leu Ala Gln Arg Asn Pro Ile Val Gln Arg Thr Arg Ala Asp Gly 
945                 950                 955                 960 


Ala Ser Phe Val Met Ser Leu Ala Ala Gly Glu Ala Ile Met Ile Pro 
                965                 970                 975     


Glu Gly Ser Lys Lys Gly Ile Trp Ile Val Gln Gly Val Trp Ala Ser 
            980                 985                 990         


Gly Gln Val Val Leu Glu Arg Asp  Thr Asp Ala Asp His  Ser Thr Thr 
        995                 1000                 1005             


Thr Arg  Pro Met Pro Asn Pro  Ile Leu Lys Asp Asp  Ala Lys Lys 
    1010                 1015                 1020             


Val Ser  Ile Asp Pro Ile Gly  Arg Val Arg Pro Ser  Asn Asp 
    1025                 1030                 1035         


<210> 378
<211> 1058
<212> PRT
<213> Pasteurella multocida


<220>
<223> Pasteurella multocida subsp. gallicida X73

<400> 378
Met Gln Thr Thr Asn Leu Ser Tyr Ile Leu Gly Leu Asp Leu Gly Ile 
1               5                   10                  15      


Ala Ser Val Gly Trp Ala Val Val Glu Ile Asn Glu Asn Glu Asp Pro 
            20                  25                  30          


Ile Gly Leu Ile Asp Val Gly Val Arg Ile Phe Glu Arg Ala Glu Val 
        35                  40                  45              


Pro Lys Thr Gly Glu Ser Leu Ala Leu Ser Arg Arg Leu Ala Arg Ser 
    50                  55                  60                  


Thr Arg Arg Leu Ile Arg Arg Arg Ala His Arg Leu Leu Leu Ala Lys 
65                  70                  75                  80  


Arg Phe Leu Lys Arg Glu Gly Ile Leu Ser Thr Thr Asp Leu Glu Lys 
                85                  90                  95      


Gly Leu Pro Asn Gln Ala Trp Glu Leu Arg Val Ala Gly Leu Glu Arg 
            100                 105                 110         


Arg Leu Ser Ala Ile Glu Trp Gly Ala Val Leu Leu His Leu Ile Lys 
        115                 120                 125             


His Arg Gly Tyr Leu Ser Lys Arg Lys Asn Glu Ser Gln Thr Asn Asn 
    130                 135                 140                 


Lys Glu Leu Gly Ala Leu Leu Ser Gly Val Ala Gln Asn His Gln Leu 
145                 150                 155                 160 


Leu Gln Ser Asp Asp Tyr Arg Thr Pro Ala Glu Leu Ala Leu Lys Lys 
                165                 170                 175     


Phe Ala Lys Glu Glu Gly His Ile Arg Asn Gln Arg Gly Ala Tyr Thr 
            180                 185                 190         


His Thr Phe Asn Arg Leu Asp Leu Leu Ala Glu Leu Asn Leu Leu Phe 
        195                 200                 205             


Ala Gln Gln His Gln Phe Gly Asn Pro His Cys Lys Glu His Ile Gln 
    210                 215                 220                 


Gln Tyr Met Thr Glu Leu Leu Met Trp Gln Lys Pro Ala Leu Ser Gly 
225                 230                 235                 240 


Glu Ala Ile Leu Lys Met Leu Gly Lys Cys Thr His Glu Lys Asn Glu 
                245                 250                 255     


Phe Lys Ala Ala Lys His Thr Tyr Ser Ala Glu Arg Phe Val Trp Leu 
            260                 265                 270         


Thr Lys Leu Asn Asn Leu Arg Ile Leu Glu Asp Gly Ala Glu Arg Ala 
        275                 280                 285             


Leu Asn Glu Glu Glu Arg Gln Leu Leu Ile Asn His Pro Tyr Glu Lys 
    290                 295                 300                 


Ser Lys Leu Thr Tyr Ala Gln Val Arg Lys Leu Leu Gly Leu Ser Glu 
305                 310                 315                 320 


Gln Ala Ile Phe Lys His Leu Arg Tyr Ser Lys Glu Ser Ala Glu Ser 
                325                 330                 335     


Ala Thr Phe Met Glu Leu Lys Ala Trp His Ala Ile Arg Lys Ala Leu 
            340                 345                 350         


Glu Asn Gln Gly Leu Lys Asp Thr Trp Gln Asp Leu Ala Lys Lys Pro 
        355                 360                 365             


Asp Leu Leu Asp Glu Ile Gly Thr Ala Phe Ser Leu Tyr Lys Thr Asp 
    370                 375                 380                 


Glu Asp Ile Gln Gln Tyr Leu Glu Gly Lys Leu Pro Asp Ser Val Ile 
385                 390                 395                 400 


Asn Ala Leu Leu Val Ser Leu Asn Phe Asp Lys Phe Ile Glu Leu Ser 
                405                 410                 415     


Leu Lys Ser Leu Arg Lys Ile Leu Pro Leu Met Glu Gln Gly Lys Arg 
            420                 425                 430         


Tyr Asp Gln Ala Cys His Glu Ile Tyr Gly His His Tyr Gly Glu Lys 
        435                 440                 445             


Asn Gln Gln Ile Ser Gln Leu Leu Pro Val Ile Pro Thr Gln Glu Ile 
    450                 455                 460                 


Arg Asn Pro Val Val Leu Arg Thr Leu Ser Gln Ala Arg Lys Val Ile 
465                 470                 475                 480 


Asn Ala Ile Ile Arg Gln Tyr Gly Ser Pro Ala Arg Val His Ile Glu 
                485                 490                 495     


Thr Gly Arg Glu Leu Gly Lys Ser Phe Lys Glu Arg Arg Glu Ile Gln 
            500                 505                 510         


Lys Gln Gln Glu Asp Asn Arg Thr Lys Arg Glu Ser Ala Val Gln Lys 
        515                 520                 525             


Phe Lys Glu Leu Phe Ser Asp Phe Ser Ser Glu Pro Lys Ser Lys Asp 
    530                 535                 540                 


Ile Leu Lys Phe Arg Leu Tyr Glu Gln Gln His Gly Lys Cys Leu Tyr 
545                 550                 555                 560 


Ser Gly Lys Glu Ile Asn Ile His Arg Leu Asn Glu Lys Gly Tyr Val 
                565                 570                 575     


Glu Ile Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp Ser Phe 
            580                 585                 590         


Asn Asn Lys Val Leu Val Leu Ala Ser Glu Asn Gln Asn Lys Gly Asn 
        595                 600                 605             


Gln Thr Pro Tyr Glu Trp Leu Gln Gly Lys Ile Asn Ser Glu Arg Trp 
    610                 615                 620                 


Lys Asn Phe Val Ala Leu Val Leu Gly Ser Gln Cys Ser Ala Ala Lys 
625                 630                 635                 640 


Lys Gln Arg Leu Leu Thr Gln Val Ile Asp Asp Asn Lys Phe Ile Asp 
                645                 650                 655     


Arg Asn Leu Asn Asp Thr Arg Tyr Ile Ala Arg Phe Leu Ser Asn Tyr 
            660                 665                 670         


Ile Gln Glu Asn Leu Leu Leu Val Gly Lys Asn Lys Lys Asn Val Phe 
        675                 680                 685             


Thr Pro Asn Gly Gln Ile Thr Ala Leu Leu Arg Ser Arg Trp Gly Leu 
    690                 695                 700                 


Ile Lys Val Arg Glu Asn Asn Asp Arg His His Ala Leu Asp Ala Ile 
705                 710                 715                 720 


Val Val Ala Cys Ala Thr Pro Ser Met Gln Gln Lys Ile Thr Arg Phe 
                725                 730                 735     


Ile Arg Phe Lys Glu Val His Pro Tyr Lys Ile Glu Asn Arg Tyr Glu 
            740                 745                 750         


Met Val Asp Gln Glu Ser Gly Glu Ile Ile Ser Pro His Phe Pro Glu 
        755                 760                 765             


Pro Trp Ala Tyr Phe Arg Gln Glu Val Asn Ile Arg Val Phe Asp Asn 
    770                 775                 780                 


His Pro Asp Thr Val Leu Lys Glu Met Leu Pro Asp Arg Pro Gln Ala 
785                 790                 795                 800 


Asn His Gln Phe Val Gln Pro Leu Phe Val Ser Arg Ala Pro Thr Arg 
                805                 810                 815     


Lys Met Ser Gly Gln Gly His Met Glu Thr Ile Lys Ser Ala Lys Arg 
            820                 825                 830         


Leu Ala Glu Gly Ile Ser Val Leu Arg Ile Pro Leu Thr Gln Leu Lys 
        835                 840                 845             


Pro Asn Leu Leu Glu Asn Met Val Asn Lys Glu Arg Glu Pro Ala Leu 
    850                 855                 860                 


Tyr Val Gly Leu Lys Ala Arg Leu Ala Glu Phe Asn Gln Asp Pro Ala 
865                 870                 875                 880 


Lys Ala Phe Ala Thr Pro Phe Tyr Lys Gln Gly Gly Gln Gln Val Lys 
                885                 890                 895     


Ala Ile Arg Val Glu Leu Val Gln Lys Ser Gly Val Leu Val Arg Gln 
            900                 905                 910         


Gly Asn Gly Val Ala Asp Asn Ala Pro Gly Ser Ile Val Arg Thr Asp 
        915                 920                 925             


Val Phe Ile Lys Asn Asn Lys Phe Phe Leu Val Pro Ile Tyr Thr Trp 
    930                 935                 940                 


Gln Val Ala Lys Gly Ile Leu Pro Asn Lys Ala Ile Val Ala His Lys 
945                 950                 955                 960 


Asn Glu Asp Glu Trp Glu Glu Met Asp Glu Gly Ala Lys Phe Lys Phe 
                965                 970                 975     


Ser Ile Phe Pro Asn Asp Leu Ile Glu Leu Arg Thr Lys Thr Glu Cys 
            980                 985                 990         


Phe Leu Gly Tyr Tyr Ile Gly Pro  Asp Arg His Asn Gly  Ser Ile Ser 
        995                 1000                 1005             


Leu Arg  Glu His Asp Ser Glu  Ile Ser Lys Gly Asn  Ala Gly Val 
    1010                 1015                 1020             


Tyr Arg  Val Gly Val Lys Leu  Ala Leu Ser Leu Glu  Lys Tyr His 
    1025                 1030                 1035             


Ile Asp  Glu Leu Gly Lys Asn  Arg Arg Ile Cys Arg  Pro His Gln 
    1040                 1045                 1050             


Arg Arg  Pro Val Arg 
    1055             


<210> 379
<211> 1056
<212> PRT
<213> Pasteurella multocida


<220>
<223> Pasteurella multocida subsp. multocida str. P52VAC

<400> 379
Met Gln Thr Thr Asn Leu Ser Tyr Ile Leu Gly Leu Asp Leu Gly Ile 
1               5                   10                  15      


Ala Ser Val Gly Trp Ala Val Val Glu Ile Asn Glu Asn Glu Asp Pro 
            20                  25                  30          


Ile Gly Leu Ile Asp Val Gly Val Arg Ile Phe Glu Arg Ala Glu Val 
        35                  40                  45              


Pro Lys Thr Gly Glu Ser Leu Ala Leu Ser Arg Arg Leu Ala Arg Ser 
    50                  55                  60                  


Thr Arg Arg Leu Ile Arg Arg Arg Ala Arg Arg Leu Leu Leu Ala Lys 
65                  70                  75                  80  


Arg Phe Leu Lys Arg Glu Gly Ile Leu Ser Thr Thr Asp Leu Glu Lys 
                85                  90                  95      


Gly Leu Pro Asn Gln Ala Trp Glu Leu Arg Val Ala Gly Leu Glu Arg 
            100                 105                 110         


Arg Leu Ser Ala Ile Glu Trp Gly Ala Val Leu Leu His Leu Ile Lys 
        115                 120                 125             


His Arg Gly Tyr Leu Ser Lys Arg Lys Asn Glu Ser Gln Thr Asn Asn 
    130                 135                 140                 


Lys Glu Leu Gly Ala Leu Leu Ser Gly Val Ala Gln Asn His Gln Leu 
145                 150                 155                 160 


Leu Gln Ser Asp Asp Tyr Arg Thr Pro Ala Glu Leu Ala Leu Lys Lys 
                165                 170                 175     


Phe Ala Lys Glu Glu Gly His Ile Arg Asn Gln Arg Gly Ala Tyr Thr 
            180                 185                 190         


His Thr Phe Asn Arg Leu Asp Leu Leu Ala Glu Leu Asn Leu Leu Phe 
        195                 200                 205             


Ala Gln Gln His Gln Phe Gly Asn Pro His Cys Lys Glu His Ile Gln 
    210                 215                 220                 


Gln Tyr Met Thr Glu Leu Leu Met Trp Gln Lys Pro Ala Leu Ser Gly 
225                 230                 235                 240 


Glu Ala Ile Leu Lys Met Leu Gly Lys Cys Thr His Glu Lys Asn Glu 
                245                 250                 255     


Phe Lys Ala Ala Lys His Thr Tyr Ser Ala Glu Arg Phe Val Trp Leu 
            260                 265                 270         


Thr Lys Leu Asn Asn Leu Arg Ile Leu Glu Asp Gly Ala Glu Arg Ala 
        275                 280                 285             


Leu Asn Glu Glu Glu Arg Gln Leu Leu Ile Asn His Pro Tyr Glu Lys 
    290                 295                 300                 


Ser Lys Leu Thr Tyr Ala Gln Val Arg Lys Leu Leu Gly Leu Ser Glu 
305                 310                 315                 320 


Gln Ala Ile Phe Lys His Leu Arg Tyr Ser Lys Glu Asn Ala Glu Ser 
                325                 330                 335     


Ala Thr Phe Met Glu Leu Lys Ala Trp His Ala Ile Arg Lys Ala Leu 
            340                 345                 350         


Glu Asn Gln Gly Leu Lys Asp Thr Trp Gln Asp Leu Ala Lys Lys Pro 
        355                 360                 365             


Asp Leu Leu Asp Glu Ile Gly Thr Ala Phe Ser Leu Tyr Lys Thr Asp 
    370                 375                 380                 


Glu Asp Ile Gln Gln Tyr Leu Thr Asn Lys Val Pro Asn Ser Val Ile 
385                 390                 395                 400 


Asn Ala Leu Leu Val Phe Leu Asn Phe Asp Lys Phe Ile Glu Leu Ala 
                405                 410                 415     


Leu Lys Ser Leu Arg Lys Ile Leu Pro Leu Met Glu Gln Gly Lys Arg 
            420                 425                 430         


Tyr Asp Gln Ala Cys Arg Glu Ile Tyr Gly His His Tyr Gly Glu Ala 
        435                 440                 445             


Asn Gln Lys Thr Ser Gln Leu Leu Pro Ala Ile Pro Ala Gln Glu Ile 
    450                 455                 460                 


Arg Asn Pro Val Val Leu Arg Thr Leu Ser Gln Ala Arg Lys Val Ile 
465                 470                 475                 480 


Asn Ala Ile Ile Arg Gln Tyr Gly Ser Pro Ala Arg Val His Ile Glu 
                485                 490                 495     


Thr Gly Arg Glu Leu Gly Lys Ser Phe Lys Glu Arg Arg Glu Ile Gln 
            500                 505                 510         


Lys Gln Gln Glu Asp Asn Arg Thr Lys Arg Glu Ser Ala Val Gln Lys 
        515                 520                 525             


Phe Lys Glu Leu Phe Ser Asp Phe Ser Ser Glu Pro Lys Ser Lys Asp 
    530                 535                 540                 


Ile Leu Lys Phe Arg Leu Tyr Glu Gln Gln His Gly Lys Cys Leu Tyr 
545                 550                 555                 560 


Ser Gly Lys Glu Ile Asn Ile His Arg Leu Asn Glu Lys Gly Tyr Val 
                565                 570                 575     


Glu Ile Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp Ser Phe 
            580                 585                 590         


Asn Asn Lys Val Leu Val Leu Ala Ser Glu Asn Gln Asn Lys Gly Asn 
        595                 600                 605             


Gln Thr Pro Tyr Glu Trp Leu Gln Gly Lys Ile Asn Ser Glu Arg Trp 
    610                 615                 620                 


Lys Asn Phe Val Ala Leu Val Leu Gly Ser Gln Cys Ser Ala Ala Lys 
625                 630                 635                 640 


Lys Gln Arg Leu Leu Thr Gln Val Ile Asp Asp Asn Lys Phe Ile Asp 
                645                 650                 655     


Arg Asn Leu Asn Asp Thr Arg Tyr Ile Ala Arg Phe Leu Ser Asn Tyr 
            660                 665                 670         


Ile Gln Glu Asn Leu Leu Leu Val Gly Lys Asn Lys Lys Asn Val Phe 
        675                 680                 685             


Thr Pro Asn Gly Gln Ile Thr Ala Leu Leu Arg Ser Arg Trp Gly Leu 
    690                 695                 700                 


Ile Lys Ile Arg Glu Asn Asn Asp Arg His His Ala Leu Asp Ala Ile 
705                 710                 715                 720 


Val Val Ala Cys Ala Thr Pro Ser Met Gln Gln Lys Ile Thr Arg Phe 
                725                 730                 735     


Ile Arg Phe Lys Glu Val His Pro Tyr Lys Ile Glu Asn Arg Tyr Glu 
            740                 745                 750         


Met Val Asp Gln Glu Ser Gly Glu Ile Ile Ser Pro His Phe Pro Glu 
        755                 760                 765             


Pro Trp Ala Tyr Phe Arg Gln Glu Val Asn Ile Arg Val Phe Asp Asn 
    770                 775                 780                 


His Pro Asp Thr Val Leu Lys Glu Met Leu Pro Asp Arg Pro Gln Ala 
785                 790                 795                 800 


Asn His Gln Phe Val Gln Pro Leu Phe Val Ser Arg Ala Pro Thr Arg 
                805                 810                 815     


Lys Met Ser Gly Gln Gly His Met Glu Thr Ile Lys Ser Ala Lys Arg 
            820                 825                 830         


Leu Ala Glu Gly Ile Ser Val Leu Arg Ile Pro Leu Thr Gln Leu Lys 
        835                 840                 845             


Pro Asn Leu Leu Glu Asn Met Val Asn Lys Glu Arg Glu Pro Ala Leu 
    850                 855                 860                 


Tyr Ala Gly Leu Lys Ala Arg Leu Ala Glu Phe Asn Gln Asp Pro Ala 
865                 870                 875                 880 


Lys Ala Phe Thr Thr Pro Phe Tyr Lys Gln Gly Gly Gln Gln Val Lys 
                885                 890                 895     


Ala Ile Arg Val Glu Gln Val Gln Lys Ser Gly Val Leu Val Arg Glu 
            900                 905                 910         


Asn Asn Gly Val Ala Asp Asn Ala Ser Ile Val Arg Thr Asp Val Phe 
        915                 920                 925             


Ile Lys Asn Asn Lys Phe Phe Leu Val Pro Ile Tyr Thr Trp Gln Val 
    930                 935                 940                 


Ala Lys Gly Ile Leu Pro Asn Lys Ala Ile Val Ala His Lys Asn Glu 
945                 950                 955                 960 


Asp Glu Trp Glu Glu Met Asp Glu Gly Ala Lys Phe Lys Phe Ser Leu 
                965                 970                 975     


Phe Pro Asn Asp Leu Val Glu Leu Lys Thr Lys Lys Glu Tyr Phe Phe 
            980                 985                 990         


Gly Tyr Tyr Ile Gly Leu Asp Arg  Ala Thr Gly Asn Ile  Ser Leu Lys 
        995                 1000                 1005             


Glu His  Asp Gly Glu Ile Ser  Lys Gly Lys Asp Gly  Val Tyr Arg 
    1010                 1015                 1020             


Val Gly  Val Lys Leu Ala Leu  Ser Phe Glu Lys Tyr  Gln Val Asp 
    1025                 1030                 1035             


Glu Leu  Gly Lys Asn Arg Gln  Ile Cys Arg Pro Gln  Gln Arg Gln 
    1040                 1045                 1050             


Pro Val  Arg 
    1055     


<210> 380
<211> 1056
<212> PRT
<213> Pasteurella multocida

<400> 380
Met Gln Thr Thr Asn Leu Ser Tyr Ile Leu Gly Leu Asp Leu Gly Ile 
1               5                   10                  15      


Ala Ser Val Gly Trp Ala Val Val Glu Ile Asn Glu Asn Glu Asp Pro 
            20                  25                  30          


Ile Gly Leu Ile Asp Val Gly Val Arg Ile Phe Glu Arg Ala Glu Val 
        35                  40                  45              


Pro Lys Thr Gly Glu Ser Leu Ala Leu Ser Arg Arg Leu Ala Arg Ser 
    50                  55                  60                  


Thr Arg Arg Leu Ile Arg Arg Arg Ala His Arg Leu Leu Leu Ala Lys 
65                  70                  75                  80  


Arg Phe Leu Lys Arg Glu Gly Ile Leu Ser Thr Ile Asp Leu Glu Lys 
                85                  90                  95      


Gly Leu Pro Asn Gln Ala Trp Glu Leu Arg Val Ala Gly Leu Glu Arg 
            100                 105                 110         


Arg Leu Ser Ala Ile Glu Trp Gly Ala Val Leu Leu His Leu Ile Lys 
        115                 120                 125             


His Arg Gly Tyr Leu Ser Lys Arg Lys Asn Glu Ser Gln Thr Asn Asn 
    130                 135                 140                 


Lys Glu Leu Gly Ala Leu Leu Ser Gly Val Ala Gln Asn His Gln Leu 
145                 150                 155                 160 


Leu Gln Ser Asp Asp Tyr Arg Thr Pro Ala Glu Leu Ala Leu Lys Lys 
                165                 170                 175     


Phe Ala Lys Glu Glu Gly His Ile Arg Asn Gln Arg Gly Ala Tyr Thr 
            180                 185                 190         


His Thr Phe Asn Arg Leu Asp Leu Leu Ala Glu Leu Asn Leu Leu Phe 
        195                 200                 205             


Ala Gln Gln His Gln Phe Gly Asn Pro His Cys Lys Glu His Ile Gln 
    210                 215                 220                 


Gln Tyr Met Thr Glu Leu Leu Met Trp Gln Lys Pro Ala Leu Ser Gly 
225                 230                 235                 240 


Glu Ala Ile Leu Lys Met Leu Gly Lys Cys Thr His Glu Lys Asn Glu 
                245                 250                 255     


Phe Lys Ala Ala Lys His Thr Tyr Ser Ala Glu Arg Phe Val Trp Leu 
            260                 265                 270         


Thr Lys Leu Asn Asn Leu Arg Ile Leu Glu Asp Gly Ala Glu Arg Ala 
        275                 280                 285             


Leu Asn Glu Glu Glu Arg Gln Leu Leu Ile Asn His Pro Tyr Glu Lys 
    290                 295                 300                 


Ser Lys Leu Thr Tyr Ala Gln Val Arg Lys Leu Leu Gly Leu Ser Glu 
305                 310                 315                 320 


Gln Ala Ile Phe Lys His Leu Arg Tyr Ser Lys Glu Asn Ala Glu Ser 
                325                 330                 335     


Ala Thr Phe Met Glu Leu Lys Ala Trp His Ala Ile Arg Lys Ala Leu 
            340                 345                 350         


Glu Asn Gln Gly Leu Lys Asp Thr Trp Gln Asp Leu Ala Lys Lys Pro 
        355                 360                 365             


Asp Leu Leu Asp Glu Ile Gly Thr Ala Phe Ser Leu Tyr Lys Thr Asp 
    370                 375                 380                 


Glu Asp Ile Gln Gln Tyr Leu Thr Asn Lys Val Pro Asn Ser Val Ile 
385                 390                 395                 400 


Asn Ala Leu Leu Val Ser Leu Asn Phe Asp Lys Phe Ile Glu Leu Ser 
                405                 410                 415     


Leu Lys Ser Leu Arg Lys Ile Leu Pro Leu Met Glu Gln Gly Lys Arg 
            420                 425                 430         


Tyr Asp Gln Ala Cys Arg Glu Ile Tyr Gly His His Tyr Gly Glu Ala 
        435                 440                 445             


Asn Gln Lys Thr Ser Gln Leu Leu Pro Ala Ile Pro Ala Gln Glu Ile 
    450                 455                 460                 


Arg Asn Pro Val Val Leu Arg Thr Leu Ser Gln Ala Arg Lys Val Ile 
465                 470                 475                 480 


Asn Ala Ile Ile Arg Gln Tyr Gly Ser Pro Ala Arg Val His Ile Glu 
                485                 490                 495     


Thr Gly Arg Glu Leu Gly Lys Ser Phe Lys Glu Arg Arg Glu Ile Gln 
            500                 505                 510         


Lys Gln Gln Glu Asp Asn Arg Thr Lys Arg Glu Ser Ala Val Gln Lys 
        515                 520                 525             


Phe Lys Glu Leu Phe Ser Asp Phe Ser Ser Glu Pro Lys Ser Lys Asp 
    530                 535                 540                 


Ile Leu Lys Phe Arg Leu Tyr Glu Gln Gln His Gly Lys Cys Leu Tyr 
545                 550                 555                 560 


Ser Gly Lys Glu Ile Asn Ile His Arg Leu Asn Glu Lys Gly Tyr Val 
                565                 570                 575     


Glu Ile Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp Ser Phe 
            580                 585                 590         


Asn Asn Lys Val Leu Val Leu Ala Ser Glu Asn Gln Asn Lys Gly Asn 
        595                 600                 605             


Gln Thr Pro Tyr Glu Trp Leu Gln Gly Lys Ile Asn Ser Glu Arg Trp 
    610                 615                 620                 


Lys Asn Phe Val Ala Leu Val Leu Gly Ser Gln Cys Ser Ala Ala Lys 
625                 630                 635                 640 


Lys Gln Arg Leu Leu Thr Gln Val Ile Asp Asp Asn Lys Phe Ile Asp 
                645                 650                 655     


Arg Asn Leu Asn Asp Thr Arg Tyr Ile Ala Arg Phe Leu Ser Asn Tyr 
            660                 665                 670         


Ile Gln Glu Asn Leu Leu Leu Val Gly Lys Asn Lys Lys Asn Val Phe 
        675                 680                 685             


Thr Pro Asn Gly Gln Ile Thr Ala Leu Leu Arg Ser Arg Trp Gly Leu 
    690                 695                 700                 


Ile Lys Ala Arg Glu Asn Asn Asn Arg His His Ala Leu Asp Ala Ile 
705                 710                 715                 720 


Val Val Ala Cys Ala Thr Pro Ser Met Gln Gln Lys Ile Thr Arg Phe 
                725                 730                 735     


Ile Arg Phe Lys Glu Val His Pro Tyr Lys Ile Glu Asn Arg Tyr Glu 
            740                 745                 750         


Met Val Asp Gln Glu Ser Gly Glu Ile Ile Ser Pro His Phe Pro Glu 
        755                 760                 765             


Pro Trp Ala Tyr Phe Arg Gln Glu Val Asn Ile Arg Val Phe Asp Asn 
    770                 775                 780                 


His Pro Asp Thr Val Leu Lys Glu Met Leu Pro Asp Arg Pro Gln Ala 
785                 790                 795                 800 


Asn His Gln Phe Val Gln Pro Leu Phe Val Ser Arg Ala Pro Thr Arg 
                805                 810                 815     


Lys Met Ser Gly Gln Gly His Met Glu Thr Ile Lys Ser Ala Lys Arg 
            820                 825                 830         


Leu Ala Glu Gly Ile Ser Val Leu Arg Ile Pro Leu Thr Gln Leu Lys 
        835                 840                 845             


Pro Asn Leu Leu Glu Asn Met Val Asn Lys Glu Arg Glu Pro Ala Leu 
    850                 855                 860                 


Tyr Ala Gly Leu Lys Ala Arg Leu Ala Glu Phe Asn Gln Asp Pro Ala 
865                 870                 875                 880 


Lys Ala Phe Ala Thr Pro Phe Tyr Lys Gln Gly Gly Gln Gln Val Lys 
                885                 890                 895     


Ala Ile Arg Val Glu Gln Val Gln Lys Ser Gly Val Leu Val Arg Glu 
            900                 905                 910         


Asn Asn Gly Val Ala Asp Asn Ala Ser Ile Val Arg Thr Asp Val Phe 
        915                 920                 925             


Ile Lys Asn Asn Lys Phe Phe Leu Val Pro Ile Tyr Thr Trp Gln Val 
    930                 935                 940                 


Ala Lys Gly Ile Leu Pro Asn Lys Ala Ile Val Ala His Lys Asn Glu 
945                 950                 955                 960 


Asp Glu Trp Glu Glu Met Asp Glu Gly Ala Lys Phe Lys Phe Ser Leu 
                965                 970                 975     


Phe Pro Asn Asp Leu Val Glu Leu Lys Thr Lys Lys Glu Tyr Phe Phe 
            980                 985                 990         


Gly Tyr Tyr Ile Gly Leu Asp Arg  Ala Thr Gly Asn Ile  Ser Leu Lys 
        995                 1000                 1005             


Glu His  Asp Gly Glu Ile Ser  Lys Gly Lys Asp Gly  Val Tyr Arg 
    1010                 1015                 1020             


Val Gly  Val Lys Leu Ala Leu  Ser Phe Glu Lys Tyr  Gln Val Asp 
    1025                 1030                 1035             


Glu Leu  Gly Lys Asn Arg Gln  Ile Cys Arg Pro Gln  Gln Arg Gln 
    1040                 1045                 1050             


Pro Val  Arg 
    1055     


<210> 381
<211> 1364
<212> PRT
<213> Pediococcus acidilactici


<220>
<223> Pediococcus acidilactici DSM 20284

<400> 381
Met Gly Asp Arg Lys Tyr Asn Leu Gly Leu Asp Ile Gly Thr Ser Ser 
1               5                   10                  15      


Ile Gly Phe Ala Ala Val Asp Glu Asn Asn Gln Pro Ile Arg Val Lys 
            20                  25                  30          


Gly Lys Thr Ala Ile Gly Val Arg Leu Phe Glu Glu Gly Lys Thr Ala 
        35                  40                  45              


Ala Asp Arg Arg Gly Phe Arg Thr Thr Arg Arg Arg Leu Ser Arg Arg 
    50                  55                  60                  


Arg Trp Arg Ile Asn Leu Leu Asn Glu Ile Phe Asp Ala His Leu Ala 
65                  70                  75                  80  


Glu Val Asp Pro Thr Phe Leu Ala Arg Leu Lys Glu Ser Asn Arg Ser 
                85                  90                  95      


Asn Leu Asp Pro Lys Lys Ser Phe Gln Gly Ser Leu Leu Phe Pro Glu 
            100                 105                 110         


Arg Lys Asp Tyr Gln Phe Tyr Glu Glu Tyr Pro Thr Ile Tyr His Leu 
        115                 120                 125             


Arg Lys Ala Leu Met Glu Lys Asp Arg Lys Phe Asp Phe Arg Glu Ile 
    130                 135                 140                 


Tyr Leu Ala Val His His Ile Ile Lys Tyr Arg Gly Asn Phe Leu Asn 
145                 150                 155                 160 


Gly Thr Pro Met Arg Ser Phe Lys Val Glu Asn Ile Glu Leu Asp Thr 
                165                 170                 175     


Leu Phe Asp Gln Leu Asn Gln Leu Tyr Ala Glu Ile Val Pro Asp Asn 
            180                 185                 190         


Glu Leu Ala Phe Asp Leu Ala Gln Val Ala Asp Val Lys Asp Val Leu 
        195                 200                 205             


Ser Ser Thr Thr Ile Tyr Lys Met Asp Lys Lys Lys Gln Leu Val Lys 
    210                 215                 220                 


Met Met Leu Leu Pro Ala Ser Asn Lys Ala Leu Gln Ser Glu Asn Lys 
225                 230                 235                 240 


Lys Ile Val Thr Gln Phe Val Asn Ala Ile Leu Asn Tyr Lys Phe Lys 
                245                 250                 255     


Leu Asp Val Leu Leu Gln Val Glu Thr Asp Ala Asp Trp Ser Leu Lys 
            260                 265                 270         


Leu Asn Asp Glu Gly Ala Asp Asp Lys Leu Glu Glu Phe Thr Gly Asp 
        275                 280                 285             


Leu Asp Glu Asn Arg Leu Glu Ile Ile Asp Leu Leu Gln Arg Leu His 
    290                 295                 300                 


Asn Trp Phe Ser Leu Asn Glu Ile Thr Lys Asp Gly Asn Ser Leu Ser 
305                 310                 315                 320 


Ala Ala Met Val Glu Lys Tyr Glu Asn His His His His Leu Gly Leu 
                325                 330                 335     


Leu Lys Lys Val Ile Glu Asn His Pro Asp Ala Lys Lys Ala Lys Ala 
            340                 345                 350         


Leu Lys Glu Thr Tyr Thr Ala Tyr Val Gly Lys Thr Asp Asp Lys Thr 
        355                 360                 365             


Gln Asn Gln Asp Asp Phe Tyr Lys Ala Val Glu Lys Asn Leu Asp Asp 
    370                 375                 380                 


Ser Pro Asp Ala Lys Glu Ile Lys Arg Leu Ile Gln Leu Asp Gln Phe 
385                 390                 395                 400 


Met Pro Lys Gln Arg Thr Gly Gln Asn Gly Ala Ile Pro His Gln Leu 
                405                 410                 415     


His Gln Gln Glu Leu Asp Gln Ile Ile Glu Lys Gln Ser Lys Tyr Tyr 
            420                 425                 430         


Pro Phe Leu Ala Glu Pro Asn Pro Asn Val Lys Arg Arg Lys Asp Ala 
        435                 440                 445             


Pro Tyr Lys Leu Asp Glu Leu Ile Ala Phe Lys Ile Pro Tyr Tyr Val 
    450                 455                 460                 


Gly Pro Leu Val Thr Pro Glu Glu Gln Ala Gln Asn Gly Glu Asn Val 
465                 470                 475                 480 


Phe Ala Trp Met Lys Arg Lys Ala Ala Gly Pro Ile Thr Pro Trp Asn 
                485                 490                 495     


Phe Asp Glu Lys Val Asp Arg Met Glu Ser Ala Asn Arg Phe Ile Arg 
            500                 505                 510         


Arg Met Thr Thr Lys Asp Thr Tyr Leu Phe Gly Glu Asp Val Leu Pro 
        515                 520                 525             


Ala Glu Ser Met Ile Tyr Gln Lys Phe Val Val Leu Asn Glu Leu Asn 
    530                 535                 540                 


Asn Leu Lys Ile Asn Gly Arg His Leu Ser Leu Lys Asp Lys Gln Asp 
545                 550                 555                 560 


Val Tyr Asn Asp Leu Phe Lys Gln Gln Lys Thr Val Ser Ile Lys Ala 
                565                 570                 575     


Leu Gln Asn Tyr Tyr Val Thr Lys Lys Lys Ala Ala Thr Ala Pro Thr 
            580                 585                 590         


Val Gly Gly Leu Ala Asp Pro Lys Lys Phe Leu Ser Ser Leu Ser Thr 
        595                 600                 605             


Tyr Ile Asp Phe Lys Asn Met Phe Gly Glu Arg Val Asn Asp Pro Gln 
    610                 615                 620                 


Phe Gln Glu Asp Leu Glu Gln Ile Val Glu Trp Ser Thr Ile Phe Glu 
625                 630                 635                 640 


Asp Arg Gly Ile Phe Lys Ala Lys Leu Gln Ala Leu Gly Trp Leu Ser 
                645                 650                 655     


Glu Lys Gln Ile Gln Gln Leu Val Ala Lys Arg Tyr Lys Gly Trp Gly 
            660                 665                 670         


Arg Leu Ser Lys Lys Leu Leu Thr Gly Leu Lys Asn Ala Glu Gly Tyr 
        675                 680                 685             


Ser Ile Leu Asp Glu Met Trp Arg Ser Thr Gly Asn Phe Met Gln Ile 
    690                 695                 700                 


Gln Ser Arg Pro Glu Phe Ala Ala Leu Ile Gln Gln Ala Asn Glu Lys 
705                 710                 715                 720 


Gln Phe Glu Gly Asn Asp Pro Asp Asn Val Trp Glu Asn Ile Glu Asn 
                725                 730                 735     


Ile Leu Gly Asp Ala Tyr Thr Ser Pro Gln Asn Lys Lys Ala Ile Arg 
            740                 745                 750         


Gln Val Val Lys Val Val Gln Asp Ile Glu Lys Ala Val Gly Asn Pro 
        755                 760                 765             


Pro Glu Lys Ile Ala Ile Glu Phe Thr Arg Glu Ala Ala Ala Asn Pro 
    770                 775                 780                 


Gln Arg Thr Gln Ser Arg Leu Arg Thr Leu Glu Lys Leu Tyr Glu Ser 
785                 790                 795                 800 


Ala Glu Glu Val Val Asp Ala Gly Leu Thr Ala Glu Leu Ala Glu Phe 
                805                 810                 815     


Lys Glu Asn Lys His Val Leu Ser Asp Lys Tyr Tyr Leu Tyr Phe Thr 
            820                 825                 830         


Gln Leu Gly Arg Asp Val Tyr Thr Gly Asp Thr Ile Ser Leu Asp Lys 
        835                 840                 845             


Leu Asn Asp Tyr Asp Val Asp His Ile Leu Pro Gln Ser Phe Ile Lys 
    850                 855                 860                 


Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ile Arg Ala Val Asn Asn 
865                 870                 875                 880 


Gly Lys Ser Asp Asn Val Pro Ala Lys Met Phe Gly Lys Lys Met Gly 
                885                 890                 895     


Ser Phe Trp Arg Tyr Leu Leu Asp Asn Gly Met Ile Ser Lys Arg Lys 
            900                 905                 910         


Tyr Asn Asn Leu Ile Thr Asp Pro Asp Asn Ile Ser Lys Tyr Ala Gln 
        915                 920                 925             


Lys Gly Phe Ile Asn Arg Gln Leu Val Glu Thr Ser Gln Val Ile Lys 
    930                 935                 940                 


Leu Thr Ala Asn Ile Leu Asn Gly Ile Tyr Asp Lys Asp Thr Glu Ile 
945                 950                 955                 960 


Ile Glu Val Pro Ala Lys Met Asn Ser Gln Met Arg Lys Met Phe Asp 
                965                 970                 975     


Leu Val Lys Val Arg Glu Val Asn Asp Tyr His His Ala Phe Asp Ala 
            980                 985                 990         


Tyr Leu Thr Ile Phe Ile Gly Asn  Tyr Leu Tyr Lys Cys  Tyr Pro Lys 
        995                 1000                 1005             


Leu Gln  Pro Tyr Phe Val Tyr  Asp Asn Phe Lys Lys  Phe Gly Asn 
    1010                 1015                 1020             


Lys Glu  Asp Ile Gly His Lys  Arg Phe Asn Phe Leu  Gly Lys Ile 
    1025                 1030                 1035             


Glu Arg  Glu Lys Lys Val Val  Ala Pro Glu Thr Gly  Glu Ile Leu 
    1040                 1045                 1050             


Trp Ser  Asn Val Ala Pro Asn  Glu Thr Ile Lys Gln  Ile Lys Lys 
    1055                 1060                 1065             


Val Tyr  Asp Tyr Lys Phe Met  Ile Val Ser Arg Glu  Ile Thr Thr 
    1070                 1075                 1080             


Arg Arg  Ala Glu Leu Phe Asn  Gln Thr Val Tyr Pro  Lys Asn Tyr 
    1085                 1090                 1095             


His Gly  Lys Leu Ile Pro Ile  Lys Glu Asp Arg Pro  Thr Asp Leu 
    1100                 1105                 1110             


Tyr Gly  Gly Tyr Ser Gly Asn  Thr Asp Ala Tyr Leu  Ala Ile Val 
    1115                 1120                 1125             


Ala Leu  Glu Asp Lys Lys Lys  Gly Lys Tyr Phe Lys  Val Val Gly 
    1130                 1135                 1140             


Ile Pro  Thr Arg Val Ala Ala  Lys Leu Glu Lys Leu  Lys Gln Gln 
    1145                 1150                 1155             


Asp Ser  Gln Gln Tyr Leu Gln  Ala Leu His Lys Val  Ile Ala Pro 
    1160                 1165                 1170             


Gln Phe  Thr Lys Ser Thr Lys  Lys Gly Ile Lys Lys  Thr Glu Phe 
    1175                 1180                 1185             


Glu Ile  Val Leu Asp Lys Val  His Tyr Arg Gln Leu  Val Gln Asp 
    1190                 1195                 1200             


Gly Pro  Val Lys Met Met Leu  Gly Ser Ser Thr Tyr  Lys Tyr Asn 
    1205                 1210                 1215             


Ala Lys  Gln Leu Val Leu Ser  Glu Lys Ala Leu Gln  Val Ile Ala 
    1220                 1225                 1230             


Asp Asp  Arg Lys Phe Asp Glu  Thr Gln Lys Asp Asp  Asn Leu Ile 
    1235                 1240                 1245             


Ala Val  Tyr Asp Glu Ile Leu  Ser Ile Val Asn Gln  Ser Phe Asp 
    1250                 1255                 1260             


Leu Tyr  Asp Ile Asn Gly Phe  Arg Lys Lys Leu Asn  Asp Asn Arg 
    1265                 1270                 1275             


Asp Gln  Phe Ile Asp Leu Pro  Ala Glu Thr Lys Tyr  Glu Gly Arg 
    1280                 1285                 1290             


Lys Val  Val Ala His Gly Lys  Arg Glu Met Ile Leu  Glu Ile Leu 
    1295                 1300                 1305             


Lys Gly  Leu His Ala Asn Ala  Ala Phe Gly Asn Leu  Lys Pro Ile 
    1310                 1315                 1320             


Gly Phe  Ser Thr Ala Phe Gly  Gln Leu Gln Val Pro  Asn Gly Ile 
    1325                 1330                 1335             


Ile Leu  Ser Lys Asn Ala Ile  Leu Ile His Gln Ser  Pro Ser Gly 
    1340                 1345                 1350             


Leu Phe  Glu Arg Lys Ile Lys  Leu Ser Asp Leu 
    1355                 1360                 


<210> 382
<211> 1366
<212> PRT
<213> Pediococcus acidilactici


<220>
<223> Pediococcus acidilactici MA18/5M

<400> 382
Met Gly Asp Arg Lys Tyr Asn Leu Gly Leu Asp Ile Gly Thr Ser Ser 
1               5                   10                  15      


Ile Gly Phe Ala Ala Val Asp Glu Asn Asn Gln Pro Ile Arg Val Lys 
            20                  25                  30          


Gly Lys Thr Ala Ile Gly Val Arg Leu Phe Glu Glu Gly Lys Thr Ala 
        35                  40                  45              


Ala Asp Arg Arg Gly Phe Arg Thr Thr Arg Arg Arg Leu Ser Arg Arg 
    50                  55                  60                  


Arg Trp Arg Ile Asn Leu Leu Asn Glu Ile Phe Asp Ala His Leu Ala 
65                  70                  75                  80  


Glu Val Asp Pro Thr Phe Leu Ala Arg Leu Lys Glu Ser Asn Arg Ser 
                85                  90                  95      


Asn Leu Asp Pro Lys Lys Ser Phe Gln Gly Ser Leu Leu Phe Pro Glu 
            100                 105                 110         


Arg Lys Asp Tyr Gln Phe Tyr Glu Glu Tyr Pro Thr Ile Tyr His Leu 
        115                 120                 125             


Arg Lys Ala Leu Met Glu Glu Asp Arg Lys Phe Asp Ile Arg Glu Ile 
    130                 135                 140                 


Tyr Leu Ala Val His His Ile Ile Lys Tyr Arg Gly Asn Phe Leu Asn 
145                 150                 155                 160 


Gly Thr Pro Met Arg Ser Phe Lys Val Glu Asn Ile Glu Leu Asp Thr 
                165                 170                 175     


Leu Phe Asp Gln Leu Asn Gln Leu Tyr Ala Glu Ile Val Pro Asp Asn 
            180                 185                 190         


Glu Leu Ala Phe Asp Leu Ala Gln Val Ala Asp Val Lys Asp Val Leu 
        195                 200                 205             


Ser Ser Thr Thr Ile Tyr Lys Met Asp Lys Lys Lys Gln Leu Val Lys 
    210                 215                 220                 


Met Met Leu Leu Pro Ala Ser Asn Lys Ala Leu Gln Ser Glu Asn Lys 
225                 230                 235                 240 


Lys Ile Val Thr Gln Phe Val Asn Ala Ile Leu Asn Tyr Lys Phe Lys 
                245                 250                 255     


Leu Asp Val Leu Leu Gln Val Glu Thr Asp Ala Asp Trp Ser Leu Lys 
            260                 265                 270         


Leu Asn Asp Glu Gly Ala Asp Asp Lys Leu Glu Glu Phe Thr Gly Asp 
        275                 280                 285             


Leu Asp Glu Asn Arg Leu Glu Ile Ile Asp Leu Leu Gln Arg Leu His 
    290                 295                 300                 


Asn Trp Phe Ser Leu Asn Glu Ile Thr Lys Asp Gly Asn Ser Leu Ser 
305                 310                 315                 320 


Ala Ala Met Val Glu Lys Tyr Glu Asn His His His His Leu Gly Leu 
                325                 330                 335     


Leu Lys Lys Val Ile Glu Asn His Pro Asp Ala Lys Lys Ala Lys Ala 
            340                 345                 350         


Leu Lys Glu Thr Tyr Thr Ala Tyr Val Gly Lys Thr Asp Asp Lys Thr 
        355                 360                 365             


Gln Asn Gln Asp Asp Phe Tyr Lys Ala Val Glu Lys Asn Leu Asp Asp 
    370                 375                 380                 


Ser Pro Asp Ala Lys Glu Ile Lys Arg Leu Ile Gln Leu Asp Gln Phe 
385                 390                 395                 400 


Met Pro Lys Gln Arg Thr Gly Gln Asn Gly Ala Ile Pro His Gln Leu 
                405                 410                 415     


His Gln Gln Glu Leu Asp Gln Ile Ile Glu Lys Gln Ser Lys Tyr Tyr 
            420                 425                 430         


Pro Phe Leu Ala Glu Pro Asn Pro Asn Val Lys Arg Arg Lys Asp Ala 
        435                 440                 445             


Pro Tyr Lys Leu Asp Glu Leu Ile Ala Phe Lys Ile Pro Tyr Tyr Val 
    450                 455                 460                 


Gly Pro Leu Val Thr Pro Glu Glu Gln Ala Gln Asn Lys Glu Asn Val 
465                 470                 475                 480 


Phe Ala Trp Met Lys Arg Lys Ala Ala Gly Pro Ile Thr Pro Trp Asn 
                485                 490                 495     


Phe Asp Glu Lys Val Asp Arg Met Glu Ser Ala Asn Arg Phe Ile Arg 
            500                 505                 510         


Arg Met Thr Thr Lys Asp Thr Tyr Leu Phe Gly Glu Asp Val Leu Pro 
        515                 520                 525             


Ala Glu Ser Met Ile Tyr Gln Lys Phe Val Val Leu Asn Glu Leu Asn 
    530                 535                 540                 


Asn Leu Lys Ile Asn Gly Arg His Leu Ser Leu Lys Asp Lys Gln Asp 
545                 550                 555                 560 


Val Tyr Asn Asp Leu Phe Lys Gln Gln Lys Thr Val Ser Ile Lys Ala 
                565                 570                 575     


Leu Gln Asn Tyr Tyr Val Thr Lys Lys Lys Ala Ala Thr Ala Pro Thr 
            580                 585                 590         


Val Gly Gly Leu Ala Asp Pro Lys Lys Phe Leu Ser Ser Leu Ser Thr 
        595                 600                 605             


Tyr Ile Asp Phe Lys Asn Met Phe Gly Glu Arg Val Asn Asp Pro Gln 
    610                 615                 620                 


Phe Gln Glu Asp Leu Glu Gln Ile Val Glu Trp Ser Thr Ile Phe Glu 
625                 630                 635                 640 


Asp Arg Gly Ile Phe Lys Ala Lys Leu Gln Ala Leu Gly Trp Leu Ser 
                645                 650                 655     


Glu Lys Gln Ile Gln Gln Leu Val Ala Lys Arg Tyr Lys Gly Trp Gly 
            660                 665                 670         


Arg Leu Ser Lys Lys Leu Leu Thr Gly Leu Lys Asn Ala Glu Gly Tyr 
        675                 680                 685             


Ser Ile Leu Asp Glu Met Trp Arg Ser Thr Glu Asn Phe Met Gln Ile 
    690                 695                 700                 


Gln Thr Arg Pro Glu Phe Ala Ala Leu Ile Gln Gln Ala Asn Glu Lys 
705                 710                 715                 720 


Gln Phe Glu Gly Asn Asp Pro Asn Asn Val Trp Glu Asn Ile Glu Ser 
                725                 730                 735     


Ile Leu Gly Asp Ala Tyr Thr Ser Pro Gln Asn Lys Lys Ala Ile Arg 
            740                 745                 750         


Gln Val Val Lys Val Val Gln Asp Ile Glu Lys Ala Val Gly Asn Pro 
        755                 760                 765             


Pro Glu Lys Ile Ala Ile Glu Phe Thr Arg Glu Ala Ala Ala Asn Pro 
    770                 775                 780                 


Gln Arg Thr Gln Ser Arg Leu Arg Thr Leu Glu Lys Leu Tyr Glu Ser 
785                 790                 795                 800 


Ala Glu Glu Val Val Asp Ala Gly Leu Thr Ala Glu Leu Ala Glu Phe 
                805                 810                 815     


Lys Glu Asn Lys His Val Leu Ser Asp Lys Tyr Tyr Leu Tyr Phe Thr 
            820                 825                 830         


Gln Leu Gly Arg Asp Val Tyr Thr Gly Asp Thr Ile Ser Leu Asp Lys 
        835                 840                 845             


Leu Asn Asp Tyr Asp Val Asp His Ile Leu Pro Gln Ser Phe Ile Lys 
    850                 855                 860                 


Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ile Arg Ala Val Asn Asn 
865                 870                 875                 880 


Gly Lys Ser Asp Asn Val Pro Ala Lys Met Phe Gly Lys Lys Met Gly 
                885                 890                 895     


Ser Phe Trp Arg Tyr Leu Leu Asp Asn Gly Met Ile Ser Lys Arg Lys 
            900                 905                 910         


Tyr Asn Asn Leu Ile Thr Asp Pro Asp Asn Ile Ser Lys Tyr Ala Gln 
        915                 920                 925             


Lys Gly Phe Ile Asn Arg Gln Leu Val Glu Thr Ser Gln Val Ile Lys 
    930                 935                 940                 


Leu Thr Ala Asn Ile Leu Asn Gly Ile Tyr Asp Lys Asp Thr Glu Ile 
945                 950                 955                 960 


Ile Glu Val Pro Ala Lys Met Asn Ser Gln Met Arg Lys Met Phe Asp 
                965                 970                 975     


Leu Val Lys Val Arg Glu Val Asn Asp Tyr His His Ala Phe Asp Ala 
            980                 985                 990         


Tyr Leu Thr Ile Phe Ile Gly Lys  Tyr Leu Tyr Lys Cys  Tyr Pro Lys 
        995                 1000                 1005             


Leu Arg  Pro Tyr Phe Val Tyr  Gly Lys Phe Lys Lys  Phe Gly Asp 
    1010                 1015                 1020             


Asn Glu  Asp Ile Glu Val Gly  Asp Gly Arg Phe Asn  Phe Leu Asn 
    1025                 1030                 1035             


Arg Ile  Glu Arg Leu Lys Asn  Val Thr Asp Pro Glu  Thr Gly Glu 
    1040                 1045                 1050             


Ile Leu  Trp Ser Asn Val Ala  Pro Asn Glu Thr Ile  Lys Gln Ile 
    1055                 1060                 1065             


Lys Lys  Val Tyr Asn Tyr Lys  Phe Met Leu Val Ser  Arg Glu Thr 
    1070                 1075                 1080             


Thr Thr  Arg Arg Ala Glu Leu  Phe Asn Gln Thr Val  Tyr Pro Lys 
    1085                 1090                 1095             


Asn Tyr  Arg Gly Lys Leu Ile  Pro Ile Lys Glu Asp  Arg Pro Thr 
    1100                 1105                 1110             


Asp Leu  Tyr Gly Gly Tyr Ser  Gly Asn Thr Asp Ala  Tyr Leu Ala 
    1115                 1120                 1125             


Ile Val  Ala Leu Glu Asp Lys  Lys Lys Gly Lys Tyr  Phe Lys Val 
    1130                 1135                 1140             


Val Gly  Ile Pro Thr Arg Ala  Ala Ala Lys Leu Glu  Lys Leu Lys 
    1145                 1150                 1155             


Gln Gln  Asp Ser Gln Gln Tyr  Leu Gln Ala Leu His  Lys Val Ile 
    1160                 1165                 1170             


Ala Pro  Gln Phe Thr Lys Ser  Thr Lys Lys Gly Ile  Lys Lys Thr 
    1175                 1180                 1185             


Glu Phe  Glu Ile Val Leu Asp  Lys Val His Tyr Arg  Gln Leu Val 
    1190                 1195                 1200             


Gln Asp  Gly Pro Val Lys Met  Met Leu Gly Ser Ser  Thr Tyr Lys 
    1205                 1210                 1215             


Tyr Asn  Ala Lys Gln Leu Val  Leu Ser Glu Lys Ala  Leu Gln Val 
    1220                 1225                 1230             


Ile Ala  Asp Asp Arg Lys Phe  Asp Glu Thr Gln Lys  Asp Asp Asn 
    1235                 1240                 1245             


Leu Ile  Ala Val Tyr Asp Glu  Ile Leu Ser Ile Val  Asn Gln Ser 
    1250                 1255                 1260             


Phe Asp  Leu Tyr Asp Ile Asn  Gly Phe Arg Lys Lys  Leu Asn Asp 
    1265                 1270                 1275             


Asn Arg  Asp Gln Phe Ile Asp  Leu Pro Ala Glu Thr  Lys Tyr Glu 
    1280                 1285                 1290             


Gly Arg  Lys Val Val Ala His  Gly Lys Arg Glu Met  Ile Leu Glu 
    1295                 1300                 1305             


Ile Leu  Lys Gly Leu His Ala  Asn Ala Ala Phe Gly  Asn Leu Lys 
    1310                 1315                 1320             


Pro Ile  Gly Phe Ser Thr Ala  Phe Gly Gln Leu Gln  Val Pro Asn 
    1325                 1330                 1335             


Gly Ile  Ile Leu Ser Lys Asn  Ala Ile Leu Ile His  Gln Ser Pro 
    1340                 1345                 1350             


Ser Gly  Leu Phe Glu Arg Lys  Ile Lys Leu Ser Asp  Leu 
    1355                 1360                 1365     


<210> 383
<211> 1364
<212> PRT
<213> Peptoniphilus duerdenii


<220>
<223> Peptoniphilus duerdenii ATCC BAA-1640

<400> 383
Met Lys Asn Leu Lys Glu Tyr Tyr Ile Gly Leu Asp Ile Gly Thr Ala 
1               5                   10                  15      


Ser Val Gly Trp Ala Val Thr Asp Glu Ser Tyr Asn Ile Pro Lys Phe 
            20                  25                  30          


Asn Gly Lys Lys Met Trp Gly Val Arg Leu Phe Asp Asp Ala Lys Thr 
        35                  40                  45              


Ala Glu Glu Arg Arg Thr Gln Arg Gly Ser Arg Arg Arg Leu Asn Arg 
    50                  55                  60                  


Arg Lys Glu Arg Ile Asn Leu Leu Gln Asp Leu Phe Ala Thr Glu Ile 
65                  70                  75                  80  


Ser Lys Val Asp Pro Asn Phe Phe Leu Arg Leu Asp Asn Ser Asp Leu 
                85                  90                  95      


Tyr Arg Glu Asp Lys Asp Glu Lys Leu Lys Ser Lys Tyr Thr Leu Phe 
            100                 105                 110         


Asn Asp Lys Asp Phe Lys Asp Arg Asp Tyr His Lys Lys Tyr Pro Thr 
        115                 120                 125             


Ile His His Leu Ile Met Asp Leu Ile Glu Asp Glu Gly Lys Lys Asp 
    130                 135                 140                 


Ile Arg Leu Leu Tyr Leu Ala Cys His Tyr Leu Leu Lys Asn Arg Gly 
145                 150                 155                 160 


His Phe Ile Phe Glu Gly Gln Lys Phe Asp Thr Lys Asn Ser Phe Asp 
                165                 170                 175     


Lys Ser Ile Asn Asp Leu Lys Ile His Leu Arg Asp Glu Tyr Asn Ile 
            180                 185                 190         


Asp Leu Glu Phe Asn Asn Glu Asp Leu Ile Glu Ile Ile Thr Asp Thr 
        195                 200                 205             


Thr Leu Asn Lys Thr Asn Lys Lys Lys Glu Leu Lys Asn Ile Val Gly 
    210                 215                 220                 


Asp Thr Lys Phe Leu Lys Ala Ile Ser Ala Ile Met Ile Gly Ser Ser 
225                 230                 235                 240 


Gln Lys Leu Val Asp Leu Phe Glu Asp Gly Glu Phe Glu Glu Thr Thr 
                245                 250                 255     


Val Lys Ser Val Asp Phe Ser Thr Thr Ala Phe Asp Asp Lys Tyr Ser 
            260                 265                 270         


Glu Tyr Glu Glu Ala Leu Gly Asp Thr Ile Ser Leu Leu Asn Ile Leu 
        275                 280                 285             


Lys Ser Ile Tyr Asp Ser Ser Ile Leu Glu Asn Leu Leu Lys Asp Ala 
    290                 295                 300                 


Asp Lys Ser Lys Asp Gly Asn Lys Tyr Ile Ser Lys Ala Phe Val Lys 
305                 310                 315                 320 


Lys Phe Asn Lys His Gly Lys Asp Leu Lys Thr Leu Lys Arg Ile Ile 
                325                 330                 335     


Lys Lys Tyr Leu Pro Ser Glu Tyr Ala Asn Ile Phe Arg Asn Lys Ser 
            340                 345                 350         


Ile Asn Asp Asn Tyr Val Ala Tyr Thr Lys Ser Asn Ile Thr Ser Asn 
        355                 360                 365             


Lys Arg Thr Lys Ala Ser Lys Phe Thr Lys Gln Glu Asp Phe Tyr Lys 
    370                 375                 380                 


Phe Ile Lys Lys His Leu Asp Thr Ile Lys Glu Thr Lys Leu Asn Ser 
385                 390                 395                 400 


Ser Glu Asn Glu Asp Leu Lys Leu Ile Asp Glu Met Leu Thr Asp Ile 
                405                 410                 415     


Glu Phe Lys Thr Phe Ile Pro Lys Leu Lys Ser Ser Asp Asn Gly Val 
            420                 425                 430         


Ile Pro Tyr Gln Leu Lys Leu Met Glu Leu Lys Lys Ile Leu Asp Asn 
        435                 440                 445             


Gln Ser Lys Tyr Tyr Asp Phe Leu Asn Glu Ser Asp Glu Tyr Gly Thr 
    450                 455                 460                 


Val Lys Asp Lys Val Glu Ser Ile Met Glu Phe Arg Ile Pro Tyr Tyr 
465                 470                 475                 480 


Val Gly Pro Leu Asn Pro Asp Ser Lys Tyr Ala Trp Ile Lys Arg Glu 
                485                 490                 495     


Asn Thr Lys Ile Thr Pro Trp Asn Phe Lys Asp Ile Val Asp Leu Asp 
            500                 505                 510         


Ser Ser Arg Glu Glu Phe Ile Asp Arg Leu Ile Gly Arg Cys Thr Tyr 
        515                 520                 525             


Leu Lys Glu Glu Lys Val Leu Pro Lys Ala Ser Leu Ile Tyr Asn Glu 
    530                 535                 540                 


Phe Met Val Leu Asn Glu Leu Asn Asn Leu Lys Leu Asn Glu Phe Leu 
545                 550                 555                 560 


Ile Thr Glu Glu Met Lys Lys Ala Ile Phe Glu Glu Leu Phe Lys Thr 
                565                 570                 575     


Lys Lys Lys Val Thr Leu Lys Ala Val Ser Asn Leu Leu Lys Lys Glu 
            580                 585                 590         


Phe Asn Leu Thr Gly Asp Ile Leu Leu Ser Gly Thr Asp Gly Asp Phe 
        595                 600                 605             


Lys Gln Gly Leu Asn Ser Tyr Ile Asp Phe Lys Asn Ile Ile Gly Asp 
    610                 615                 620                 


Lys Val Asp Arg Asp Asp Tyr Arg Ile Lys Ile Glu Glu Ile Ile Lys 
625                 630                 635                 640 


Leu Ile Val Leu Tyr Glu Asp Asp Lys Thr Tyr Leu Lys Lys Lys Ile 
                645                 650                 655     


Lys Ser Ala Tyr Lys Asn Asp Phe Thr Asp Asp Glu Ile Lys Lys Ile 
            660                 665                 670         


Ala Ala Leu Asn Tyr Lys Asp Trp Gly Arg Leu Ser Lys Arg Phe Leu 
        675                 680                 685             


Thr Gly Ile Glu Gly Val Asp Lys Thr Thr Gly Glu Lys Gly Ser Ile 
    690                 695                 700                 


Ile Tyr Phe Met Arg Glu Tyr Asn Leu Asn Leu Met Glu Leu Met Ser 
705                 710                 715                 720 


Gly His Tyr Thr Phe Thr Glu Glu Val Glu Lys Leu Asn Pro Val Glu 
                725                 730                 735     


Asn Arg Glu Leu Cys Tyr Glu Met Val Asp Glu Leu Tyr Leu Ser Pro 
            740                 745                 750         


Ser Val Lys Arg Met Leu Trp Gln Ser Leu Arg Val Val Asp Glu Ile 
        755                 760                 765             


Lys Arg Ile Ile Gly Lys Asp Pro Lys Lys Ile Phe Ile Glu Met Ala 
    770                 775                 780                 


Arg Ala Lys Glu Ala Lys Asn Ser Arg Lys Glu Ser Arg Lys Asn Lys 
785                 790                 795                 800 


Leu Leu Glu Phe Tyr Lys Phe Gly Lys Lys Ala Phe Ile Asn Glu Ile 
                805                 810                 815     


Gly Glu Glu Arg Tyr Asn Tyr Leu Leu Asn Glu Ile Asn Ser Glu Glu 
            820                 825                 830         


Glu Ser Lys Phe Arg Trp Asp Asn Leu Tyr Leu Tyr Tyr Thr Gln Leu 
        835                 840                 845             


Gly Arg Cys Met Tyr Ser Leu Glu Pro Ile Asp Leu Ala Asp Leu Lys 
    850                 855                 860                 


Ser Asn Asn Ile Tyr Asp Gln Asp His Ile Tyr Pro Lys Ser Lys Ile 
865                 870                 875                 880 


Tyr Asp Asp Ser Leu Glu Asn Arg Val Leu Val Lys Lys Asn Leu Asn 
                885                 890                 895     


His Glu Lys Gly Asn Gln Tyr Pro Ile Pro Glu Lys Val Leu Asn Lys 
            900                 905                 910         


Asn Ala Tyr Gly Phe Trp Lys Ile Leu Phe Asp Lys Gly Leu Ile Gly 
        915                 920                 925             


Gln Lys Lys Tyr Thr Arg Leu Thr Arg Arg Thr Pro Phe Glu Glu Arg 
    930                 935                 940                 


Glu Leu Ala Glu Phe Ile Glu Arg Gln Ile Val Glu Thr Arg Gln Ala 
945                 950                 955                 960 


Thr Lys Glu Thr Ala Asn Leu Leu Lys Asn Ile Cys Gln Asp Ser Glu 
                965                 970                 975     


Ile Val Tyr Ser Lys Ala Glu Asn Ala Ser Arg Phe Arg Gln Glu Phe 
            980                 985                 990         


Asp Ile Ile Lys Cys Arg Thr Val  Asn Asp Leu His His  Met His Asp 
        995                 1000                 1005             


Ala Tyr  Leu Asn Ile Val Val  Gly Asn Val Tyr Asn  Thr Lys Phe 
    1010                 1015                 1020             


Thr Lys  Asn Pro Leu Asn Phe  Ile Lys Asp Lys Asp  Asn Val Arg 
    1025                 1030                 1035             


Ser Tyr  Asn Leu Glu Asn Met  Phe Lys Tyr Asp Val  Val Arg Gly 
    1040                 1045                 1050             


Ser Tyr  Thr Ala Trp Ile Ala  Asp Asp Ser Glu Gly  Asn Val Lys 
    1055                 1060                 1065             


Ala Ala  Thr Ile Lys Lys Val  Lys Arg Glu Leu Glu  Gly Lys Asn 
    1070                 1075                 1080             


Tyr Arg  Phe Thr Arg Met Ser  Tyr Ile Gly Thr Gly  Gly Leu Tyr 
    1085                 1090                 1095             


Asp Gln  Asn Leu Met Arg Lys  Gly Lys Gly Gln Ile  Pro Gln Lys 
    1100                 1105                 1110             


Glu Asn  Thr Asn Lys Ser Asn  Ile Glu Lys Tyr Gly  Gly Tyr Asn 
    1115                 1120                 1125             


Lys Ala  Ser Ser Ala Tyr Phe  Ala Leu Ile Glu Ser  Asp Gly Lys 
    1130                 1135                 1140             


Ala Gly  Arg Glu Arg Thr Leu  Glu Thr Ile Pro Ile  Met Val Tyr 
    1145                 1150                 1155             


Asn Gln  Glu Lys Tyr Gly Asn  Thr Glu Ala Val Asp  Lys Tyr Leu 
    1160                 1165                 1170             


Lys Asp  Asn Leu Glu Leu Gln  Asp Pro Lys Ile Leu  Lys Asp Lys 
    1175                 1180                 1185             


Ile Lys  Ile Asn Ser Leu Ile  Lys Leu Asp Gly Phe  Leu Tyr Asn 
    1190                 1195                 1200             


Ile Lys  Gly Lys Thr Gly Asp  Ser Leu Ser Ile Ala  Gly Ser Val 
    1205                 1210                 1215             


Gln Leu  Ile Val Asn Lys Glu  Glu Gln Lys Leu Ile  Lys Lys Met 
    1220                 1225                 1230             


Asp Lys  Phe Leu Val Lys Lys  Lys Asp Asn Lys Asp  Ile Lys Val 
    1235                 1240                 1245             


Thr Ser  Phe Asp Asn Ile Lys  Glu Glu Glu Leu Ile  Lys Leu Tyr 
    1250                 1255                 1260             


Lys Thr  Leu Ser Asp Lys Leu  Asn Asn Gly Ile Tyr  Ser Asn Lys 
    1265                 1270                 1275             


Arg Asn  Asn Gln Ala Lys Asn  Ile Ser Glu Ala Leu  Asp Lys Phe 
    1280                 1285                 1290             


Lys Glu  Ile Ser Ile Glu Glu  Lys Ile Asp Val Leu  Asn Gln Ile 
    1295                 1300                 1305             


Ile Leu  Leu Phe Gln Ser Tyr  Asn Asn Gly Cys Asn  Leu Lys Ser 
    1310                 1315                 1320             


Ile Gly  Leu Ser Ala Lys Thr  Gly Val Val Phe Ile  Pro Lys Lys 
    1325                 1330                 1335             


Leu Asn  Tyr Lys Glu Cys Lys  Leu Ile Asn Gln Ser  Ile Thr Gly 
    1340                 1345                 1350             


Leu Phe  Glu Asn Glu Val Asp  Leu Leu Asn Leu 
    1355                 1360                 


<210> 384
<211> 1087
<212> PRT
<213> Phascolarctobacterium succinatutens


<220>
<223> Phascolarctobacterium succinatutens YIT 12067

<400> 384
Met Leu Arg Met Lys Tyr Ala Ile Gly Leu Asp Ile Gly Ile Ala Ser 
1               5                   10                  15      


Val Gly Tyr Ala Val Leu Ala Leu Asp His Glu Glu Asn Pro Trp Gly 
            20                  25                  30          


Ile Ile Arg Leu Gly Ser Arg Ile Phe Asp Val Ala Glu Asn Pro Lys 
        35                  40                  45              


Asp Gly Ala Ser Leu Ala Leu Pro Arg Arg Glu Ala Arg Ser Val Arg 
    50                  55                  60                  


Arg Arg Leu Arg Arg His His His Arg Leu Glu Arg Ile Lys Asn Leu 
65                  70                  75                  80  


Leu Ile Asn Thr Glu Phe Ile Thr Lys Asp Glu Leu Leu His Leu Tyr 
                85                  90                  95      


Asp Gly Asn Leu Ser Asp Val Tyr Glu Leu Arg Val Lys Ala Leu Asp 
            100                 105                 110         


Tyr Ser Val Thr Asn Ala Glu Leu Thr Arg Ile Leu Leu His Leu Ala 
        115                 120                 125             


Gln Arg Arg Gly Phe Lys Ser Asn Arg Lys Ser Asp Ala Asn Asp Lys 
    130                 135                 140                 


Glu Ala Gly Gln Leu Leu Glu Ala Val Ser Ala Asn Ala Lys Arg Met 
145                 150                 155                 160 


Gln Glu Asn His Tyr Arg Thr Val Gly Glu Met Phe Tyr Lys Asp Asp 
                165                 170                 175     


Leu Phe Ser Lys Tyr Lys Arg Asn Lys Gly Gly Thr Tyr Leu Thr Thr 
            180                 185                 190         


Val His Arg Asp Met Ile Ala Ala Glu Ala Arg Thr Ile Leu Glu Lys 
        195                 200                 205             


Gln Phe Ala Leu Gly Asn Asn Ile Cys Thr Gln Asp Phe Ile Asp Lys 
    210                 215                 220                 


Tyr Leu Ser Ile Leu Leu Ser Gln Arg Gln Phe Asp Glu Gly Pro Gly 
225                 230                 235                 240 


Glu Pro Ser Pro Tyr Ala Gly Asn Gln Ile Ala Asn Met Ile Gly Lys 
                245                 250                 255     


Cys Thr Phe Glu Pro Asn Glu Tyr Arg Ala Ala Lys Ala Ser Tyr Ser 
            260                 265                 270         


Phe Glu Arg Phe Asn Leu Leu Gln Lys Val Asn His Leu Arg Leu Leu 
        275                 280                 285             


Leu Glu Gly Lys Ser Ile Ala Leu Asp Asn Glu Gln Arg Lys Lys Ile 
    290                 295                 300                 


Ile Ala Leu Ala His Asp Lys Ala Asp Leu Arg Tyr Ser His Ile Arg 
305                 310                 315                 320 


Lys Ala Leu Gly Leu Asp Glu Lys Val Leu Phe Asn Thr Ile Thr Tyr 
                325                 330                 335     


Asn Asp Asp Val Ser Val Ile Glu Lys Lys Thr Lys Phe Asn Phe Leu 
            340                 345                 350         


Gln Ala Tyr His Gln Ile Lys Lys Val Leu Ala Glu Asp Met Gln Lys 
        355                 360                 365             


Leu Thr Thr Glu Gln Leu Asp Asn Ile Gly Gln Ile Leu Ser Thr Tyr 
    370                 375                 380                 


Lys Ser Asp Asn Lys Arg Thr Glu Glu Leu Ser Ala Leu Gly Leu Glu 
385                 390                 395                 400 


Lys Lys Ile Ile Asp Ala Leu Leu Gly Ile Asn Gly Leu Ser Lys Phe 
                405                 410                 415     


Ala His Leu Ser Leu Lys Ala Leu Arg Lys Ile Asn Pro Tyr Leu Glu 
            420                 425                 430         


Glu Gly Lys Ile Tyr Asn Glu Ala Cys Thr Ala Ala Gly Tyr Asp Phe 
        435                 440                 445             


Lys Ala His Ala Asn Thr Gln Lys Thr Glu Leu Leu Pro Ala Tyr Lys 
    450                 455                 460                 


Glu Glu Met Asp Asp Ile Thr Ser Pro Val Ala Arg Arg Ala Ile Ala 
465                 470                 475                 480 


Gln Ser Ile Lys Val Ile Asn Ala Ile Ile Arg Glu Gln Lys Gly Ser 
                485                 490                 495     


Pro Leu Tyr Ile Asn Ile Glu Leu Ala Arg Glu Met Ala Lys Gly Phe 
            500                 505                 510         


Asp Glu Arg Thr Gln Ile Asp Lys Ala Asn Lys Glu Asn Gln Ala Lys 
        515                 520                 525             


Asn Glu Arg Ile Met Glu Arg Ile Arg Thr Glu Phe His Lys Ala Asn 
    530                 535                 540                 


Pro Thr Gly Met Asp Leu Ile Lys Leu Lys Leu Trp Glu Glu Gln Asp 
545                 550                 555                 560 


Gly Arg Ser Pro Tyr Ser Gln Lys Ala Ile Ser Ile Asn Arg Leu Phe 
                565                 570                 575     


Glu Pro Gly Tyr Val Asp Ile Asp His Ile Val Pro Tyr Ser Ile Ser 
            580                 585                 590         


Phe Asp Asp Ser Phe Lys Asn Lys Val Leu Val Phe Ser Asp Glu Asn 
        595                 600                 605             


Arg Asp Lys Gly Asn Arg Leu Pro Ile Ala Tyr Leu Gln Ser Lys Phe 
    610                 615                 620                 


Gly Ala Lys Ala Ala Glu Asn Phe Met Ile Trp Val Gln Ser Asn Ile 
625                 630                 635                 640 


Lys Asp Tyr Lys Lys Arg Gln Lys Leu Leu Lys Arg Glu Ile Thr Glu 
                645                 650                 655     


Glu Asp Ile Asn Lys Phe Lys Glu Arg Asn Leu Gln Asp Thr Lys Thr 
            660                 665                 670         


Ile Ser Arg Phe Leu Tyr Asn Tyr Ile Asn Asp Tyr Leu Leu Phe Ala 
        675                 680                 685             


Pro Ser Asp Thr Gly Lys Lys Lys Arg Val Thr Ala Val Asn Gly Thr 
    690                 695                 700                 


Ile Thr Ala Tyr Leu Arg Lys Arg Trp Gly Ile Asn Lys Ile Arg Ala 
705                 710                 715                 720 


Asn Gly Asp Lys His His Ala Val Asp Ala Val Val Ile Ala Cys Thr 
                725                 730                 735     


Thr Asp Lys Met Ile Lys Asp Leu Ser Ser Phe Ser Arg Tyr His Glu 
            740                 745                 750         


Leu Glu Tyr Thr His Thr Asp Thr Glu Ser Phe Leu Val Asn Ser Leu 
        755                 760                 765             


Thr Gly Glu Ile Leu Lys Arg Phe Pro Tyr Pro Trp Glu Asp Phe Arg 
    770                 775                 780                 


Pro Glu Leu Met Ala Arg Leu Ser Asp Asn Pro Ala Asp Ala Leu Arg 
785                 790                 795                 800 


Lys Leu Asn Leu Ile Phe Tyr His Gly Ile Asp Leu Ser Thr Ile Lys 
                805                 810                 815     


Pro Ile Phe Val Ser Arg Met Pro Arg His Lys Val Thr Gly Ala Ala 
            820                 825                 830         


His Lys Ala Thr Ile Lys Ser Ala Arg Cys Leu Asp Asn Gly Ile Val 
        835                 840                 845             


Ile Cys Lys Thr Ser Leu Gln Asn Leu Lys Leu Asp Lys Glu Gly Glu 
    850                 855                 860                 


Ile Ala Asn Tyr Tyr Ala Pro Glu Ser Asp Thr Ile Leu Tyr Asn Ala 
865                 870                 875                 880 


Leu Lys Glu Arg Leu Arg Ser Tyr Asp Asn Lys Pro Ala Lys Ala Phe 
                885                 890                 895     


Ala Glu Pro Phe Tyr Lys Pro Lys Ala Asp Gly Thr Pro Gly Pro Leu 
            900                 905                 910         


Val Lys Lys Val Lys Val Tyr Glu Lys Ser Thr Leu Asn Val Ala Val 
        915                 920                 925             


Gln Gln Asn Thr Ala Val Ala Asp Asn Asp Ser Met Val Arg Val Asp 
    930                 935                 940                 


Val Phe His Val Lys Gly Asn Gly Tyr Tyr Leu Val Pro Ile Tyr Ile 
945                 950                 955                 960 


Ala Asp Thr Leu Lys Lys Glu Leu Pro Asn Lys Ala Ile Val Ala Tyr 
                965                 970                 975     


Lys Pro Tyr Ala Asp Trp Pro Val Met Asp Asp Ser Asn Phe Ile Phe 
            980                 985                 990         


Ser Leu Tyr Pro Asn Asp Leu Ile  Lys Phe Glu His Lys  Asn Ser Val 
        995                 1000                 1005             


Lys Phe  Ala Lys Val Asn Lys  Glu Ser Thr Leu Asn  Asp Phe Tyr 
    1010                 1015                 1020             


Ser Thr  Lys Ser Glu Ile Val  Tyr Phe Lys Gly Cys  Asn Ile Asn 
    1025                 1030                 1035             


Thr Gly  Ala Ile Thr Ile Ile  Asn His Glu Asn Thr  Tyr Val Val 
    1040                 1045                 1050             


Ser Ser  Leu Gly Val Lys Thr  Leu Pro Ser Leu Glu  Lys Tyr Gln 
    1055                 1060                 1065             


Ala Asp  Val Leu Gly Asn Tyr  Thr Lys Val Lys Lys  Glu Val Arg 
    1070                 1075                 1080             


Lys Pro  Phe Arg 
    1085         


<210> 385
<211> 1333
<212> PRT
<213> Planococcus antarcticus


<220>
<223> Planococcus antarcticus DSM 14505

<400> 385
Met Lys Asn Tyr Thr Ile Gly Leu Asp Ile Gly Val Ala Ser Val Gly 
1               5                   10                  15      


Trp Val Cys Ile Asp Glu Asn Tyr Lys Ile Leu Asn Tyr Asn Asn Arg 
            20                  25                  30          


His Ala Phe Gly Val His Glu Phe Glu Ser Ala Glu Ser Ala Ala Gly 
        35                  40                  45              


Arg Arg Leu Lys Arg Gly Met Arg Arg Arg Tyr Asn Arg Arg Lys Lys 
    50                  55                  60                  


Arg Leu Gln Leu Leu Gln Ser Leu Phe Asp Ser Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gly Phe Phe Ser Lys Thr Asp Ser Gln His Phe Trp Lys Asn Asn Asn 
                85                  90                  95      


Glu Phe Glu Asn Arg Ser Leu Thr Glu Val Leu Ser Ser Leu Arg Ile 
            100                 105                 110         


Ser Ser Arg Lys Tyr Pro Thr Ile Tyr His Leu Arg Ser Asp Leu Ile 
        115                 120                 125             


Glu Ser Asn Lys Lys Met Asp Leu Arg Leu Val Tyr Leu Ala Leu His 
    130                 135                 140                 


Asn Leu Val Lys Tyr Arg Gly His Phe Leu Gln Glu Gly Asn Trp Ser 
145                 150                 155                 160 


Glu Ala Ala Ser Ala Glu Gly Met Asp Asp Gln Leu Leu Glu Leu Val 
                165                 170                 175     


Thr Arg Tyr Ala Glu Leu Glu Asn Leu Ser Pro Leu Asp Leu Ser Glu 
            180                 185                 190         


Ser Gln Trp Lys Ala Ala Glu Thr Leu Leu Leu Asn Arg Asn Leu Thr 
        195                 200                 205             


Lys Thr Asp Gln Ser Lys Glu Leu Thr Ala Met Phe Gly Lys Glu Tyr 
    210                 215                 220                 


Glu Pro Phe Cys Lys Leu Val Ala Gly Leu Gly Val Ser Leu His Gln 
225                 230                 235                 240 


Leu Phe Pro Ser Ser Glu Gln Ala Leu Ala Tyr Lys Glu Thr Lys Thr 
                245                 250                 255     


Lys Val Gln Leu Ser Asn Glu Asn Val Glu Glu Val Met Glu Leu Leu 
            260                 265                 270         


Leu Glu Glu Glu Ser Ala Leu Leu Glu Ala Val Gln Pro Phe Tyr Gln 
        275                 280                 285             


Gln Val Val Leu Tyr Glu Leu Leu Lys Gly Glu Thr Tyr Val Ala Lys 
    290                 295                 300                 


Ala Lys Val Ser Ala Phe Lys Gln Tyr Gln Lys Asp Met Ala Ser Leu 
305                 310                 315                 320 


Lys Asn Leu Leu Asp Lys Thr Phe Gly Glu Lys Val Tyr Arg Ser Tyr 
                325                 330                 335     


Phe Ile Ser Asp Lys Asn Ser Gln Arg Glu Tyr Gln Lys Ser His Lys 
            340                 345                 350         


Val Glu Val Leu Cys Lys Leu Asp Gln Phe Asn Lys Glu Ala Lys Phe 
        355                 360                 365             


Ala Glu Thr Phe Tyr Lys Asp Leu Lys Lys Leu Leu Glu Asp Lys Ser 
    370                 375                 380                 


Lys Thr Ser Ile Gly Thr Thr Glu Lys Asp Glu Met Leu Arg Ile Ile 
385                 390                 395                 400 


Lys Ala Ile Asp Ser Asn Gln Phe Leu Gln Lys Gln Lys Gly Ile Gln 
                405                 410                 415     


Asn Ala Ala Ile Pro His Gln Asn Ser Leu Tyr Glu Ala Glu Lys Ile 
            420                 425                 430         


Leu Arg Asn Gln Gln Ala His Tyr Pro Phe Ile Thr Thr Glu Trp Ile 
        435                 440                 445             


Glu Lys Val Lys Gln Ile Leu Ala Phe Arg Ile Pro Tyr Tyr Ile Gly 
    450                 455                 460                 


Pro Leu Val Lys Asp Thr Thr Gln Ser Pro Phe Ser Trp Val Glu Arg 
465                 470                 475                 480 


Lys Gly Asp Ala Pro Ile Thr Pro Trp Asn Phe Asp Glu Gln Ile Asp 
                485                 490                 495     


Lys Ala Ala Ser Ala Glu Ala Phe Ile Ser Arg Met Arg Lys Thr Cys 
            500                 505                 510         


Thr Tyr Leu Lys Gly Gln Glu Val Leu Pro Lys Ser Ser Leu Thr Tyr 
        515                 520                 525             


Glu Arg Phe Glu Val Leu Asn Glu Leu Asn Gly Ile Gln Leu Arg Thr 
    530                 535                 540                 


Thr Gly Ala Glu Ser Asp Phe Arg His Arg Leu Ser Tyr Glu Met Lys 
545                 550                 555                 560 


Cys Trp Ile Ile Asp Asn Val Phe Lys Gln Tyr Lys Thr Val Ser Thr 
                565                 570                 575     


Lys Arg Leu Leu Gln Glu Leu Lys Lys Ser Pro Tyr Ala Asp Glu Leu 
            580                 585                 590         


Tyr Asp Glu His Thr Gly Glu Ile Lys Glu Val Phe Gly Thr Gln Lys 
        595                 600                 605             


Glu Asn Ala Phe Ala Thr Ser Leu Ser Gly Tyr Ile Ser Met Lys Ser 
    610                 615                 620                 


Ile Leu Gly Ala Val Val Asp Asp Asn Pro Ala Met Thr Glu Glu Leu 
625                 630                 635                 640 


Ile Tyr Trp Ile Ala Val Phe Glu Asp Arg Glu Ile Leu His Leu Lys 
                645                 650                 655     


Ile Gln Glu Lys Tyr Pro Ser Ile Thr Asp Val Gln Arg Gln Lys Leu 
            660                 665                 670         


Ala Leu Val Lys Leu Pro Gly Trp Gly Arg Phe Ser Arg Leu Leu Ile 
        675                 680                 685             


Asp Gly Leu Pro Leu Asp Glu Gln Gly Gln Ser Val Leu Asp His Met 
    690                 695                 700                 


Glu Gln Tyr Ser Ser Val Phe Met Glu Val Leu Lys Asn Lys Gly Phe 
705                 710                 715                 720 


Gly Leu Glu Lys Lys Ile Gln Lys Met Asn Gln His Gln Val Asp Gly 
                725                 730                 735     


Thr Lys Lys Ile Arg Tyr Glu Asp Ile Glu Glu Leu Ala Gly Ser Pro 
            740                 745                 750         


Ala Leu Lys Arg Gly Ile Trp Arg Ser Val Lys Ile Val Glu Glu Leu 
        755                 760                 765             


Val Ser Ile Phe Gly Glu Pro Ala Asn Ile Val Leu Glu Val Ala Arg 
    770                 775                 780                 


Glu Asp Gly Glu Lys Lys Arg Thr Lys Ser Arg Lys Asp Gln Trp Glu 
785                 790                 795                 800 


Glu Leu Thr Lys Thr Thr Leu Lys Asn Asp Pro Asp Leu Lys Ser Phe 
                805                 810                 815     


Ile Gly Glu Ile Lys Ser Gln Gly Asp Gln Arg Phe Asn Glu Gln Arg 
            820                 825                 830         


Phe Trp Leu Tyr Val Thr Gln Gln Gly Lys Cys Leu Tyr Thr Gly Lys 
        835                 840                 845             


Ala Leu Asp Ile Gln Asn Leu Ser Met Tyr Glu Val Asp His Ile Leu 
    850                 855                 860                 


Pro Gln Asn Phe Val Lys Asp Asp Ser Leu Asp Asn Leu Ala Leu Val 
865                 870                 875                 880 


Met Pro Glu Ala Asn Gln Arg Lys Asn Gln Val Gly Gln Asn Lys Met 
                885                 890                 895     


Pro Leu Glu Ile Ile Glu Ala Asn Gln Gln Tyr Ala Met Arg Thr Leu 
            900                 905                 910         


Trp Glu Arg Leu His Glu Leu Lys Leu Ile Ser Ser Gly Lys Leu Gly 
        915                 920                 925             


Arg Leu Lys Lys Pro Ser Phe Asp Glu Val Asp Lys Asp Lys Phe Ile 
    930                 935                 940                 


Ala Arg Gln Leu Val Glu Thr Arg Gln Ile Ile Lys His Val Arg Asp 
945                 950                 955                 960 


Leu Leu Asp Glu Arg Phe Ser Lys Ser Asp Ile His Leu Val Lys Ala 
                965                 970                 975     


Gly Ile Val Ser Lys Phe Arg Arg Phe Ser Glu Ile Pro Lys Ile Arg 
            980                 985                 990         


Asp Tyr Asn Asn Lys His His Ala  Met Asp Ala Leu Phe  Ala Ala Ala 
        995                 1000                 1005             


Leu Ile  Gln Ser Ile Leu Gly  Lys Tyr Gly Lys Asn  Phe Leu Ala 
    1010                 1015                 1020             


Phe Asp  Leu Ser Lys Lys Asp  Arg Gln Lys Gln Trp  Arg Ser Val 
    1025                 1030                 1035             


Lys Gly  Ser Asn Lys Glu Phe  Phe Leu Phe Lys Asn  Phe Gly Asn 
    1040                 1045                 1050             


Leu Arg  Leu Gln Ser Pro Val  Thr Gly Glu Glu Val  Ser Gly Val 
    1055                 1060                 1065             


Glu Tyr  Met Lys His Val Tyr  Phe Glu Leu Pro Trp  Gln Thr Thr 
    1070                 1075                 1080             


Lys Met  Thr Gln Thr Gly Asp  Gly Met Phe Tyr Lys  Glu Ser Ile 
    1085                 1090                 1095             


Phe Ser  Pro Lys Val Lys Gln  Ala Lys Tyr Val Ser  Pro Lys Thr 
    1100                 1105                 1110             


Glu Lys  Phe Val His Asp Glu  Val Lys Asn His Ser  Ile Cys Leu 
    1115                 1120                 1125             


Val Glu  Phe Thr Phe Met Lys  Lys Glu Lys Glu Val  Gln Glu Thr 
    1130                 1135                 1140             


Lys Phe  Ile Asp Leu Lys Val  Ile Glu His His Gln  Phe Leu Lys 
    1145                 1150                 1155             


Glu Pro  Glu Ser Gln Leu Ala  Lys Phe Leu Ala Glu  Lys Glu Thr 
    1160                 1165                 1170             


Asn Ser  Pro Ile Ile His Ala  Arg Ile Ile Arg Thr  Ile Pro Lys 
    1175                 1180                 1185             


Tyr Gln  Lys Ile Trp Ile Glu  His Phe Pro Tyr Tyr  Phe Ile Ser 
    1190                 1195                 1200             


Thr Arg  Glu Leu His Asn Ala  Arg Gln Phe Glu Ile  Ser Tyr Glu 
    1205                 1210                 1215             


Leu Met  Glu Lys Val Lys Gln  Leu Ser Glu Arg Ser  Ser Val Glu 
    1220                 1225                 1230             


Glu Leu  Lys Ile Val Phe Gly  Leu Leu Ile Asp Gln  Met Asn Asp 
    1235                 1240                 1245             


Asn Tyr  Pro Ile Tyr Thr Lys  Ser Ser Ile Gln Asp  Arg Val Gln 
    1250                 1255                 1260             


Lys Phe  Val Asp Thr Gln Leu  Tyr Asp Phe Lys Ser  Phe Glu Ile 
    1265                 1270                 1275             


Gly Phe  Glu Glu Leu Lys Lys  Ala Val Ala Ala Asn  Ala Gln Arg 
    1280                 1285                 1290             


Ser Asp  Thr Phe Gly Ser Arg  Ile Ser Lys Lys Pro  Lys Pro Glu 
    1295                 1300                 1305             


Glu Val  Ala Ile Gly Tyr Glu  Ser Ile Thr Gly Leu  Lys Tyr Arg 
    1310                 1315                 1320             


Lys Pro  Arg Ser Val Val Gly  Thr Lys Arg 
    1325                 1330             


<210> 386
<211> 1197
<212> PRT
<213> Porphyromonas sp.


<220>
<223> Porphyromonas sp. oral taxon 279 str. F0450

<400> 386
Met Leu Met Ser Lys His Val Leu Gly Leu Asp Leu Gly Val Gly Ser 
1               5                   10                  15      


Ile Gly Trp Cys Leu Ile Ala Leu Asp Ala Gln Gly Asp Pro Ala Glu 
            20                  25                  30          


Ile Leu Gly Met Gly Ser Arg Val Val Pro Leu Asn Asn Ala Thr Lys 
        35                  40                  45              


Ala Ile Glu Ala Phe Asn Ala Gly Ala Ala Phe Thr Ala Ser Gln Glu 
    50                  55                  60                  


Arg Thr Ala Arg Arg Thr Met Arg Arg Gly Phe Ala Arg Tyr Gln Leu 
65                  70                  75                  80  


Arg Arg Tyr Arg Leu Arg Arg Glu Leu Glu Lys Val Gly Met Leu Pro 
                85                  90                  95      


Asp Ala Ala Leu Ile Gln Leu Pro Leu Leu Glu Leu Trp Glu Leu Arg 
            100                 105                 110         


Glu Arg Ala Ala Thr Ala Gly Arg Arg Leu Thr Leu Pro Glu Leu Gly 
        115                 120                 125             


Arg Val Leu Cys His Ile Asn Gln Lys Arg Gly Tyr Arg His Val Lys 
    130                 135                 140                 


Ser Asp Ala Ala Ala Ile Val Gly Asp Glu Gly Glu Lys Lys Lys Asp 
145                 150                 155                 160 


Ser Asn Ser Ala Tyr Leu Ala Gly Ile Arg Ala Asn Asp Glu Lys Leu 
                165                 170                 175     


Gln Ala Glu His Lys Thr Val Gly Gln Tyr Phe Ala Glu Gln Leu Arg 
            180                 185                 190         


Gln Asn Gln Ser Glu Ser Pro Thr Gly Gly Ile Ser Tyr Arg Ile Lys 
        195                 200                 205             


Asp Gln Ile Phe Ser Arg Gln Cys Tyr Ile Asp Glu Tyr Asp Gln Ile 
    210                 215                 220                 


Met Ala Val Gln Arg Val His Tyr Pro Asp Ile Leu Thr Asp Glu Phe 
225                 230                 235                 240 


Ile Arg Met Leu Arg Asp Glu Val Ile Phe Met Gln Arg Pro Leu Lys 
                245                 250                 255     


Ser Cys Lys His Leu Val Ser Leu Cys Glu Phe Glu Lys Gln Glu Arg 
            260                 265                 270         


Val Met Arg Val Gln Gln Asp Asp Gly Lys Gly Gly Trp Gln Leu Val 
        275                 280                 285             


Glu Arg Arg Val Lys Phe Gly Pro Lys Val Ala Pro Lys Ser Ser Pro 
    290                 295                 300                 


Leu Phe Gln Leu Cys Cys Ile Tyr Glu Ala Val Asn Asn Ile Arg Leu 
305                 310                 315                 320 


Thr Arg Pro Asn Gly Ser Pro Cys Asp Ile Thr Pro Glu Glu Arg Ala 
                325                 330                 335     


Lys Ile Val Ala His Leu Gln Ser Ser Ala Ser Leu Ser Phe Ala Ala 
            340                 345                 350         


Leu Lys Lys Leu Leu Lys Glu Lys Ala Leu Ile Ala Asp Gln Leu Thr 
        355                 360                 365             


Ser Lys Ser Gly Leu Lys Gly Asn Ser Thr Arg Val Ala Leu Ala Ser 
    370                 375                 380                 


Ala Leu Gln Pro Tyr Pro Gln Tyr His His Leu Leu Asp Met Glu Leu 
385                 390                 395                 400 


Glu Thr Arg Met Met Thr Val Gln Leu Thr Asp Glu Glu Thr Gly Glu 
                405                 410                 415     


Val Thr Glu Arg Glu Val Ala Val Val Thr Asp Ser Tyr Val Arg Lys 
            420                 425                 430         


Pro Leu Tyr Arg Leu Trp His Ile Leu Tyr Ser Ile Glu Glu Arg Glu 
        435                 440                 445             


Ala Met Arg Arg Ala Leu Ile Thr Gln Leu Gly Met Lys Glu Glu Asp 
    450                 455                 460                 


Leu Asp Gly Gly Leu Leu Asp Gln Leu Tyr Arg Leu Asp Phe Val Lys 
465                 470                 475                 480 


Pro Gly Tyr Gly Asn Lys Ser Ala Lys Phe Ile Cys Lys Leu Leu Pro 
                485                 490                 495     


Gln Leu Gln Gln Gly Leu Gly Tyr Ser Glu Ala Cys Ala Ala Val Gly 
            500                 505                 510         


Tyr Arg His Ser Asn Ser Pro Thr Ser Glu Glu Ile Thr Glu Arg Thr 
        515                 520                 525             


Leu Leu Glu Lys Ile Pro Leu Leu Gln Arg Asn Glu Leu Arg Gln Pro 
    530                 535                 540                 


Leu Val Glu Lys Ile Leu Asn Gln Met Ile Asn Leu Val Asn Ala Leu 
545                 550                 555                 560 


Lys Ala Glu Tyr Gly Ile Asp Glu Val Arg Val Glu Leu Ala Arg Glu 
                565                 570                 575     


Leu Lys Met Ser Arg Glu Glu Arg Glu Arg Met Ala Arg Asn Asn Lys 
            580                 585                 590         


Asp Arg Glu Glu Arg Asn Lys Gly Val Ala Ala Lys Ile Arg Glu Cys 
        595                 600                 605             


Gly Leu Tyr Pro Thr Lys Pro Arg Ile Gln Lys Tyr Met Leu Trp Lys 
    610                 615                 620                 


Glu Ala Gly Arg Gln Cys Leu Tyr Cys Gly Arg Ser Ile Glu Glu Glu 
625                 630                 635                 640 


Gln Cys Leu Arg Glu Gly Gly Met Glu Val Glu His Ile Ile Pro Lys 
                645                 650                 655     


Ser Val Leu Tyr Asp Asp Ser Tyr Gly Asn Lys Thr Cys Ala Cys Arg 
            660                 665                 670         


Arg Cys Asn Lys Glu Lys Gly Asn Arg Thr Ala Leu Glu Tyr Ile Arg 
        675                 680                 685             


Ala Lys Gly Arg Glu Ala Glu Tyr Met Lys Arg Ile Asn Asp Leu Leu 
    690                 695                 700                 


Lys Glu Lys Lys Ile Ser Tyr Ser Lys His Gln Arg Leu Arg Trp Leu 
705                 710                 715                 720 


Lys Glu Asp Ile Pro Ser Asp Phe Leu Glu Arg Gln Leu Arg Leu Thr 
                725                 730                 735     


Gln Tyr Ile Ser Arg Gln Ala Met Ala Ile Leu Gln Gln Gly Ile Arg 
            740                 745                 750         


Arg Val Ser Ala Ser Glu Gly Gly Val Thr Ala Arg Leu Arg Ser Leu 
        755                 760                 765             


Trp Gly Tyr Gly Lys Ile Leu His Thr Leu Asn Leu Asp Arg Tyr Asp 
    770                 775                 780                 


Ser Met Gly Glu Thr Glu Arg Val Ser Arg Glu Gly Glu Ala Thr Glu 
785                 790                 795                 800 


Glu Leu His Ile Thr Asn Trp Ser Lys Arg Met Asp His Arg His His 
                805                 810                 815     


Ala Ile Asp Ala Leu Val Val Ala Cys Thr Arg Gln Ser Tyr Ile Gln 
            820                 825                 830         


Arg Leu Asn Arg Leu Ser Ser Glu Phe Gly Arg Glu Asp Lys Lys Lys 
        835                 840                 845             


Glu Asp Gln Glu Ala Gln Glu Gln Gln Ala Thr Glu Thr Gly Arg Leu 
    850                 855                 860                 


Ser Asn Leu Glu Arg Trp Leu Thr Gln Arg Pro His Phe Ser Val Arg 
865                 870                 875                 880 


Thr Val Ser Asp Lys Val Ala Glu Ile Leu Ile Ser Tyr Arg Pro Gly 
                885                 890                 895     


Gln Arg Val Val Thr Arg Gly Arg Asn Ile Tyr Arg Lys Lys Met Ala 
            900                 905                 910         


Asp Gly Arg Glu Val Ser Cys Val Gln Arg Gly Val Leu Val Pro Arg 
        915                 920                 925             


Gly Glu Leu Met Glu Ala Ser Phe Tyr Gly Lys Ile Leu Ser Gln Gly 
    930                 935                 940                 


Arg Val Arg Ile Val Lys Arg Tyr Pro Leu His Asp Leu Lys Gly Glu 
945                 950                 955                 960 


Val Val Asp Pro His Leu Arg Glu Leu Ile Thr Thr Tyr Asn Gln Glu 
                965                 970                 975     


Leu Lys Ser Arg Glu Lys Gly Ala Pro Ile Pro Pro Leu Cys Leu Asp 
            980                 985                 990         


Lys Asp Lys Lys Gln Glu Val Arg  Ser Val Arg Cys Tyr  Ala Lys Thr 
        995                 1000                 1005             


Leu Ser  Leu Asp Lys Ala Ile  Pro Met Cys Phe Asp  Glu Lys Gly 
    1010                 1015                 1020             


Glu Pro  Thr Ala Phe Val Lys  Ser Ala Ser Asn His  His Leu Ala 
    1025                 1030                 1035             


Leu Tyr  Arg Thr Pro Lys Gly  Lys Leu Val Glu Ser  Ile Val Thr 
    1040                 1045                 1050             


Phe Trp  Asp Ala Val Asp Arg  Ala Arg Tyr Gly Ile  Pro Leu Val 
    1055                 1060                 1065             


Ile Thr  His Pro Arg Glu Val  Met Glu Gln Val Leu  Gln Arg Gly 
    1070                 1075                 1080             


Asp Ile  Pro Glu Gln Val Leu  Ser Leu Leu Pro Pro  Ser Asp Trp 
    1085                 1090                 1095             


Val Phe  Val Asp Ser Leu Gln  Gln Asp Glu Met Val  Val Ile Gly 
    1100                 1105                 1110             


Leu Ser  Asp Glu Glu Leu Gln  Arg Ala Leu Glu Ala  Gln Asn Tyr 
    1115                 1120                 1125             


Arg Lys  Ile Ser Glu His Leu  Tyr Arg Val Gln Lys  Met Ser Ser 
    1130                 1135                 1140             


Ser Tyr  Tyr Val Phe Arg Tyr  His Leu Glu Thr Ser  Val Ala Asp 
    1145                 1150                 1155             


Asp Lys  Asn Thr Ser Gly Arg  Ile Pro Lys Phe His  Arg Val Gln 
    1160                 1165                 1170             


Ser Leu  Lys Ala Tyr Glu Glu  Arg Asn Ile Arg Lys  Val Arg Val 
    1175                 1180                 1185             


Asp Leu  Leu Gly Arg Ile Ser  Leu Leu 
    1190                 1195         


<210> 387
<211> 1485
<212> PRT
<213> Prevotella bivia


<220>
<223> Prevotella bivia JCVIHMP010

<400> 387
Met Lys Asn Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Lys Ile Ser Ile Asp Asp Asn Gly Lys Tyr Ile Lys Asp Ser Ile 
            20                  25                  30          


Lys Leu Gly Ser Arg Ile Ile Pro Met Ser Gln Asp Val Leu Ser Asn 
        35                  40                  45              


Phe Ser Lys Gly Val Thr Leu Ser Gln Thr Ser Glu Arg Thr Ser Phe 
    50                  55                  60                  


Arg Gly Ala Arg Arg Leu Arg Glu Arg Thr Leu Leu Arg Arg Glu Arg 
65                  70                  75                  80  


Leu His Arg Ile Leu His Leu Leu Gly Phe Leu Pro Lys His Tyr Glu 
                85                  90                  95      


Lys Ala Ile Gly Trp Asp Arg Asn Asp Asn Lys Thr Tyr Gly Lys Phe 
            100                 105                 110         


Ile Asn His Ala Glu Pro Lys Leu Ala Trp Cys Lys Asp Asn Asn Gly 
        115                 120                 125             


Lys Met Arg Phe Leu Phe Met Asp Ser Phe His Asp Met Leu Ser Glu 
    130                 135                 140                 


Phe Ser Glu Lys His Pro Glu Leu Leu Ala Asn Gly Lys Lys Ile Pro 
145                 150                 155                 160 


Leu Asp Trp Thr Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Tyr Lys Ala 
                165                 170                 175     


Ile Thr Lys Glu Glu Leu Ala Trp Ile Leu Leu Asn Phe Asn Gln Lys 
            180                 185                 190         


Arg Gly Tyr Tyr Gln Leu Arg Gly Glu Glu Asp Arg Asp Ser Glu Ala 
        195                 200                 205             


Asn Lys Lys Glu Tyr Leu Glu Leu Lys Val Ile Gly Val Glu Ala Thr 
    210                 215                 220                 


Gly Glu Lys Lys Gly Asn Asp Ile Trp Tyr Asn Ile His Leu Glu Asn 
225                 230                 235                 240 


Gly Trp Ile Tyr Arg Arg Ser Ser Lys Asn Pro Leu Asn Asp Trp Leu 
                245                 250                 255     


Gly Lys Val Lys Ser Phe Ile Val Thr Thr Asp Leu Asp Ala Asp Gly 
            260                 265                 270         


Asn Pro Lys Lys Asp Lys Asp Gly Asn Ile Lys Arg Ser Phe Arg Ala 
        275                 280                 285             


Pro Ser Glu Gly Asp Trp Thr Leu Ile Lys Lys Arg Thr Glu Ser Leu 
    290                 295                 300                 


Leu Glu Asn Ser Gly Gln Thr Val Gly Gln Phe Ile Tyr Asn His Ile 
305                 310                 315                 320 


Leu Glu Glu Pro Ser Ala Lys Ile Arg Gly Asn Phe Ile Arg Thr Ile 
                325                 330                 335     


Glu Arg Lys Tyr Tyr Lys Asp Glu Leu Lys Ala Ile Leu Glu Lys Gln 
            340                 345                 350         


Lys Glu Phe His His Glu Leu Ser Ser Glu Ser Leu Leu Thr Glu Cys 
        355                 360                 365             


Ala Lys Glu Leu Tyr Lys Arg Asn Ile Ala His Gln Glu Val Leu Leu 
    370                 375                 380                 


Lys Lys Gly Ile Ile His Leu Leu Leu Asn Asp Ile Leu Phe Tyr Gln 
385                 390                 395                 400 


Arg Pro Leu Lys Ile Lys Lys Ser Leu Ile Asp Asn Cys Pro Tyr Glu 
                405                 410                 415     


Asn Tyr Lys Tyr Val Asp Lys Lys Ser Gly Asp Ile Lys Val Lys Ser 
            420                 425                 430         


Ile Lys Cys Ile Ala Lys Ser Asn Pro Phe Phe Gln Glu Phe Arg Leu 
        435                 440                 445             


Trp Gln Phe Val Ser Asn Leu Arg Leu Tyr Arg Lys Ser Asp Asp Lys 
    450                 455                 460                 


Asp Val Thr Ser Glu His Leu Val Thr Thr Asp Asp Tyr Ala Asn Leu 
465                 470                 475                 480 


Phe Thr Tyr Leu Asn Asn Arg Lys Asp Ile Lys Gln Ser Val Leu Leu 
                485                 490                 495     


Lys Glu Tyr Phe Lys Ile Lys Lys Val Lys Thr Ile Asn Gly Ala Glu 
            500                 505                 510         


Tyr Pro Val Arg Trp Asn Tyr Ile Asp Asp Asp Asn Lys Thr Tyr Pro 
        515                 520                 525             


Cys Asn Glu Thr Arg Tyr Asp Ile Leu His Ala Leu Ser Lys Thr Glu 
    530                 535                 540                 


Leu Lys Ser Glu Trp Leu Thr Pro Glu Arg Thr Tyr Arg Leu Trp His 
545                 550                 555                 560 


Leu Leu Tyr Ser Ile Glu Ser Lys Glu Glu Thr Lys Lys Ala Leu Asn 
                565                 570                 575     


Lys Leu Asn Leu Ser Asp Asp Phe Thr Glu Ala Phe Leu Thr Ile Lys 
            580                 585                 590         


Pro Phe Lys Lys Glu Tyr Gly Ser Tyr Ser Glu Lys Ala Ile Lys Lys 
        595                 600                 605             


Leu Leu Ser Leu Met Arg Met Gly Tyr Leu Trp Ser Glu Asp Glu Ala 
    610                 615                 620                 


Ile Lys Gln Val Gly Ala Glu Ile Glu Lys Thr Ile Glu Gly Glu Leu 
625                 630                 635                 640 


Pro Asp Tyr Val Leu Gln Arg Leu Glu Lys Ser Gln His Asn Tyr Asn 
                645                 650                 655     


Lys Ile Ser Asp Phe Ser Gly Leu Pro Leu Trp Leu Ala Ser Tyr Ile 
            660                 665                 670         


Ile Tyr Gly Arg His Ser Glu Ala Lys Glu Ile Ile His Trp Asp Asn 
        675                 680                 685             


Pro Glu Ser Met Met Ala Tyr Ile Lys Asp Phe Arg Gln His Ser Met 
    690                 695                 700                 


Arg Asn Pro Ile Val Glu Gln Cys Val Leu Glu Thr Leu Arg Thr Val 
705                 710                 715                 720 


His Asp Ile Trp Lys Glu Ile Gly His Ile Asp Glu Ile His Ile Glu 
                725                 730                 735     


Leu Gly Arg Glu Met Lys Ser Thr Ser Glu Gln Arg Lys Ala Ile Thr 
            740                 745                 750         


Gln Asn Val Leu His Asn Gln Asn Thr Asn Ile Arg Ile Lys Leu Leu 
        755                 760                 765             


Leu Gln Glu Leu Lys Asn Asp Asn Asn Ile Thr Gly Val Arg Pro Tyr 
    770                 775                 780                 


Ser Pro Met Gln Gln Glu Ile Leu Arg Ile Tyr Glu Glu Gly Ala Leu 
785                 790                 795                 800 


Gln Gly Leu Thr Lys Glu Asp Lys Asp Tyr Asn Asp Ile Leu Lys Ile 
                805                 810                 815     


Ser Gln Thr Ala Gln Pro Thr Ser Asn Glu Leu Thr Arg Tyr Lys Leu 
            820                 825                 830         


Trp Leu Glu Gln Lys Tyr Arg Ser Pro Tyr Thr Gly Lys Ala Ile Ser 
        835                 840                 845             


Leu Ser Lys Leu Phe Thr Ser Ala Tyr Gln Ile Glu His Val Ile Pro 
    850                 855                 860                 


Gln Ser Arg Tyr Phe Asp Asp Ser Leu Ser Asn Lys Val Ile Cys Glu 
865                 870                 875                 880 


Ser Glu Val Asn Thr Leu Lys Lys Ala Met Leu Gly Met Glu Phe Ile 
                885                 890                 895     


Lys Thr Cys Gly Gly Gln Lys Val His Cys Thr Leu Leu Gly Asp Val 
            900                 905                 910         


Glu Ile Tyr Asn Glu Glu Asp Tyr Lys Ala Phe Val Asn Glu His Tyr 
        915                 920                 925             


Ser Asn Asn Arg Thr Lys Arg Asn Lys Leu Leu Met Glu Asp Ile Pro 
    930                 935                 940                 


Gln Glu Phe Ile Asn Arg Gln Leu Asn Asp Ser Arg Tyr Ile Ser Lys 
945                 950                 955                 960 


Met Val Lys Gln Leu Leu Ser Ala Ile Val Arg Gly Gln Glu Glu Val 
                965                 970                 975     


Glu Ala Thr Ser Lys Phe Val Ile Pro Cys Thr Gly Gly Ile Thr Asp 
            980                 985                 990         


Arg Leu Lys Lys Asp Trp Gly Leu  Asn Asp Ile Trp Asn  Asn Leu Val 
        995                 1000                 1005             


Ser Pro  Arg Phe Gln Arg Met  Asn Ala Leu Thr Gly  Ser Glu Tyr 
    1010                 1015                 1020             


Phe Gly  His Trp Glu Asn Lys  Glu Gly Lys Arg Val  Phe Gln Thr 
    1025                 1030                 1035             


Thr Met  Pro Ile Gln Leu Gln  Gln Gly Phe Ser Lys  Lys Arg Ile 
    1040                 1045                 1050             


Asp His  Arg His His Ala Met  Asp Ala Leu Val Ile  Ala Cys Ala 
    1055                 1060                 1065             


Ser Arg  Asn Ile Ile Ser Tyr  Leu Asn Asn Glu Thr  Ala Gln Asp 
    1070                 1075                 1080             


Thr Glu  Arg Arg Arg Asp Leu  Arg Gln Lys Leu Cys  Asp Lys Gly 
    1085                 1090                 1095             


Gly Ser  Val Arg Lys Pro Trp  Asp Ser Phe Thr Gln  Asp Thr Gln 
    1100                 1105                 1110             


Tyr Ala  Leu Lys Asp Ile Ile  Val Thr Phe Lys Asn  Tyr Val Arg 
    1115                 1120                 1125             


Ile Ile  Asn Lys Ala Thr Asn  Tyr Tyr Glu His Tyr  Lys Thr Asp 
    1130                 1135                 1140             


Gly Lys  Lys Gly Met Ile Ser  Gln Lys Gly Asp Glu  Leu Trp Ala 
    1145                 1150                 1155             


Ile Arg  Lys Pro Met His Lys  Glu Thr Val Phe Gly  Lys Val Asn 
    1160                 1165                 1170             


Leu Arg  Arg Pro Lys Arg Val  Ser Leu Ser Lys Ala  Ile Asp Ser 
    1175                 1180                 1185             


Val Asp  Ile Ile Cys Asn Arg  Lys Leu Lys Lys Tyr  Ile Lys Ala 
    1190                 1195                 1200             


Arg Leu  Asn Glu Gly Leu Gln  Lys Lys Gln Ile Leu  Asn Ile Phe 
    1205                 1210                 1215             


Lys Glu  Leu Asn Asn Val Trp  Glu Gly Ile Asp Val  Asn Lys Ile 
    1220                 1225                 1230             


Asp Ile  Trp Glu Met Ser Asn  Asp Lys Glu Pro Met  Val Ala Thr 
    1235                 1240                 1245             


Arg Lys  Gln Leu Asp Thr Ser  Phe Asp Glu Lys Lys  Ile Arg Ser 
    1250                 1255                 1260             


Ile Ser  Asp Thr Gly Ile Gln  Lys Ile Leu Leu Asn  Tyr Leu Ile 
    1265                 1270                 1275             


Thr Lys  Asn Asn Asn Pro Glu  Leu Ala Phe Thr Pro  Glu Gly Ile 
    1280                 1285                 1290             


Gln Glu  Met Asn Ser Asn Ile  Ser Glu Tyr Asn Asp  His Lys Lys 
    1295                 1300                 1305             


His Gln  Pro Ile Tyr Lys Val  Arg Val Thr Glu Pro  Leu Gly Ala 
    1310                 1315                 1320             


Lys Tyr  Pro Ile Gly Thr Met  Gly Asn Asn Pro Lys  Lys Phe Val 
    1325                 1330                 1335             


Glu Ala  Gln Ala Gly Thr Asn  Leu Tyr Phe Ala Ile  Tyr Glu Asp 
    1340                 1345                 1350             


Lys Glu  Gly Lys Arg Asn Tyr  Asp Thr Ile Pro Leu  Asn Ile Ala 
    1355                 1360                 1365             


Ala Glu  Arg Leu Asn Gln Gln  Leu Ser Pro Val Pro  Glu Thr Asn 
    1370                 1375                 1380             


Glu Asn  Asn Thr Pro Leu Lys  Phe Tyr Leu Ser Pro  Asn Asp Leu 
    1385                 1390                 1395             


Val Tyr  Val Pro Ser Glu Glu  Glu Arg His Ser Gly  Asn Asn Ile 
    1400                 1405                 1410             


Gln Leu  Asp Lys Asn Arg Ile  Tyr Lys Met Val Ser  Ser Thr Ser 
    1415                 1420                 1425             


Lys Arg  Cys Phe Phe Ile His  His Arg Val Ala Ile  Ser Leu Val 
    1430                 1435                 1440             


Asp Lys  Lys Glu Phe Ser Ala  Gln Asn Lys Met Glu  Arg Ser Ile 
    1445                 1450                 1455             


Asp Asn  Glu Gln Val Met Ile  Lys Ser Val Cys Trp  Lys Leu Ile 
    1460                 1465                 1470             


Thr Asp  Arg Leu Gly Asn Ile  Ile Lys Val Ile Lys  
    1475                 1480                 1485 


<210> 388
<211> 1457
<212> PRT
<213> Prevotella buccae


<220>
<223> Prevotella buccae ATCC 33574

<400> 388
Met Lys Thr Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Lys Val Ser Val Asp Asp Tyr Gly Asn Tyr Leu His Asp Ile Lys 
            20                  25                  30          


Leu Gly Ser Arg Ile Ile Pro Met Ser Gln Asp Val Leu Gly Asn Phe 
        35                  40                  45              


Asp Ser Gly Val Thr Val Ser Gln Thr Ala Gln Arg Thr Glu Phe Arg 
    50                  55                  60                  


Ser Lys Arg Arg Leu Val Gln Arg Asn Leu Gln Arg Arg Glu Arg Leu 
65                  70                  75                  80  


His Arg Val Leu His Val Leu Asp Phe Leu Pro Ala His Tyr Asp Ala 
                85                  90                  95      


Ala Ile Gly Trp Asp Arg Thr Glu Ala Val Thr Tyr Gly Lys Phe Leu 
            100                 105                 110         


Asn His Ala Glu Pro Lys Leu Ala Trp Glu Glu Leu Gly Asn Gly Lys 
        115                 120                 125             


Arg Arg Phe Leu Phe Met Asp Ser Phe His Glu Met Val Ala Asp Phe 
    130                 135                 140                 


Ala Arg Cys Gln Pro Ala Leu Val Ala Asp Gly Lys Lys Ile Pro Leu 
145                 150                 155                 160 


Asp Trp Thr Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Thr Gln Ala Ile 
                165                 170                 175     


Thr Lys Glu Glu Leu Ala Trp Ile Leu Leu Asn Phe Asn Gln Lys Arg 
            180                 185                 190         


Gly Tyr Tyr Gln Leu Arg Gly Glu Glu Glu Glu Glu Asn Pro Thr Lys 
        195                 200                 205             


Gln Glu Glu Tyr Tyr Glu Leu Lys Val Val Ser Val Glu Ala Thr Asp 
    210                 215                 220                 


Ser Arg Lys Gly Asn Asp Thr Trp Tyr Asn Val His Leu Glu Asn Gly 
225                 230                 235                 240 


Trp Ile Tyr Arg Arg Ser Ser Lys Ile Ser Leu Asp Asp Trp Val Gly 
                245                 250                 255     


Lys Val Lys Gln Phe Ile Val Thr Thr Glu Tyr Glu Lys Asp Gly Ala 
            260                 265                 270         


Thr Leu Lys Thr Asp Lys Glu Gly Tyr Val Lys Arg Ser Phe Arg Ala 
        275                 280                 285             


Pro Asn Glu Asn Asp Trp Gly Leu Arg Lys Lys Arg Thr Glu Thr Leu 
    290                 295                 300                 


Leu Glu Met Ser Gly Lys Thr Val Gly Ala Phe Ile Tyr Asp His Leu 
305                 310                 315                 320 


Leu Gln Glu Pro Ala Asp Lys Ile Arg Gly Asn Phe Ile Arg Thr Ile 
                325                 330                 335     


Glu Arg His Tyr Tyr Lys Ala Glu Leu Glu Ala Ile Leu Ala Glu Gln 
            340                 345                 350         


Cys Lys Tyr His Ile Glu Leu Arg Asp Lys Glu Met Leu Glu Ala Cys 
        355                 360                 365             


Ala Arg Glu Leu Tyr Leu Asn Asn Leu Pro His Gln Arg Ser Leu Met 
    370                 375                 380                 


Lys Lys Asp Met Thr Tyr Leu Leu Leu Tyr Asp Leu Ile Phe Tyr Gln 
385                 390                 395                 400 


Arg Pro Leu Lys Ser Lys Lys Ala Leu Ile Ala Asn Cys Pro Tyr Glu 
                405                 410                 415     


Tyr Tyr Glu Tyr Val Asp Lys Glu Thr Gly Glu Ile Lys Arg Gln Asn 
            420                 425                 430         


Ile Lys Cys Ile Ala Lys Ser Asn Pro Tyr Phe Gln Glu Phe Arg Leu 
        435                 440                 445             


Trp Gln Phe Val Leu Asn Leu Arg Leu Phe Asp Arg Val Glu Asp Lys 
    450                 455                 460                 


Glu Val Thr Ala Asn Tyr Leu Pro Thr Ala Asp Asp His Ala Arg Leu 
465                 470                 475                 480 


Phe Thr Tyr Leu Asn Asp Arg Lys Glu Ile Asn Gln Glu Thr Leu Leu 
                485                 490                 495     


Lys Asp Tyr Phe Lys Leu Lys Lys Val Lys Ile Gly Asn Glu Lys Glu 
            500                 505                 510         


Tyr Pro Ile Arg Trp Asn Tyr Ile Glu Asp Lys Glu Lys Lys Tyr Pro 
        515                 520                 525             


Cys Asn Glu Thr Arg Tyr Glu Leu Leu Met Ala Leu Asp Arg Ala Gly 
    530                 535                 540                 


Ile Glu His Lys Trp Leu Asp Asp Asn Asn Leu Glu Tyr Arg Leu Trp 
545                 550                 555                 560 


His Leu Leu Tyr Ser Val Glu Val Lys Ser Glu Ser Glu Thr Ala Leu 
                565                 570                 575     


Arg Lys Leu Lys Asn Asp Asp Ala Phe Val Asn Ser Phe Leu Lys Val 
            580                 585                 590         


Lys Pro Phe Lys Lys Glu Tyr Gly Ala Tyr Ser Glu Lys Ala Ile Lys 
        595                 600                 605             


Arg Leu Leu Ala Val Met Arg Lys Gly Phe Leu Trp Asn Glu Gln Asp 
    610                 615                 620                 


Ile Cys Asp Glu Thr Arg Lys Arg Ile Glu Ile Ile Ile Lys Gly Asp 
625                 630                 635                 640 


Val Asp Glu Lys Val Lys Glu Arg Met Gly His Ala Ala Tyr Ser Phe 
                645                 650                 655     


Asp Arg Val Ser Asp Phe Gln Gly Leu Pro Glu Trp Leu Ala Cys Tyr 
            660                 665                 670         


Val Val Tyr Gly Arg His Ser Glu Ala Met Asp Ile Gln His Trp Asp 
        675                 680                 685             


Ser Pro Glu Arg Leu Met Ala Tyr Ile Asn Asn Phe Lys Gln Tyr Ser 
    690                 695                 700                 


Leu Arg Asn Pro Ile Val Glu Gln Cys Ile Leu Glu Thr Leu Arg Thr 
705                 710                 715                 720 


Val His Asp Ile Trp Lys Glu Thr Gly Gln Ile Asp Glu Ile His Val 
                725                 730                 735     


Glu Leu Gly Arg Glu Met Lys Ser Thr Ser Glu Glu Arg Ala Arg Arg 
            740                 745                 750         


Thr Gln Asn Val Leu Arg Asn Glu Asn Thr Asn Leu Arg Ile Lys Ser 
        755                 760                 765             


Leu Leu Ile Glu Leu Lys Asn Asp Thr Asp Ile Cys Asn Val His Pro 
    770                 775                 780                 


Tyr Ser Pro Met Gln Gln Glu Ile Leu Arg Ile Tyr Glu Glu Gly Ala 
785                 790                 795                 800 


Leu Gln Glu Leu Asn Arg Glu Asp Glu Asp Phe Glu Glu Ile Ser Lys 
                805                 810                 815     


Ile Ser Gln Met Ser Gln Pro Ser Gly Lys Glu Leu Asn Arg Tyr Lys 
            820                 825                 830         


Leu Trp Leu Glu Gln Lys Tyr Arg Ser Pro Tyr Thr Gly Lys Ala Ile 
        835                 840                 845             


Ser Leu Ala Lys Leu Phe Thr Pro Ala Tyr Gln Ile Glu His Val Ile 
    850                 855                 860                 


Pro Gln Ser Arg Tyr Phe Asp Asp Ser Phe Thr Asn Lys Val Ile Cys 
865                 870                 875                 880 


Glu Ala Glu Val Asn Thr Leu Lys Ser Asn Leu Leu Gly Tyr Glu Phe 
                885                 890                 895     


Ile Lys Lys His Gly Gly Glu Ile Ile His Cys Thr Thr Leu Gly Asp 
            900                 905                 910         


Val Arg Ile Phe Ser Glu Ser Glu Tyr Lys Ala Phe Val Met Asp His 
        915                 920                 925             


Tyr Ala Asn Asn Lys Ser Lys Lys Asp Lys Leu Leu Met Glu Asp Ile 
    930                 935                 940                 


Pro Gln Glu Phe Leu Ser Arg Gln Met Asn Asp Ser Arg Tyr Ile Ser 
945                 950                 955                 960 


Lys Val Val Lys Thr Leu Leu Ser Asn Ile Val Arg Met Ala Asp Glu 
                965                 970                 975     


Ser Glu Ala Thr Ser Lys Ser Val Ile Val Cys Thr Gly Gly Val Thr 
            980                 985                 990         


Asp Arg Leu Lys Lys Asp Trp Gly  Leu Asn Asp Val Trp  Asn Ser Ile 
        995                 1000                 1005             


Val Tyr  Ser Arg Phe Glu Arg  Leu Asn Arg Leu Thr  Gly Thr Glu 
    1010                 1015                 1020             


Ala Phe  Gly His Trp Glu Asn  Lys Asp Gly Lys Arg  Val Phe Gln 
    1025                 1030                 1035             


Thr Ser  Met Pro Leu Glu Leu  Gln Arg Gly Phe Arg  Lys Lys Arg 
    1040                 1045                 1050             


Ile Asp  His Arg His His Ala  Met Asp Ala Leu Val  Ile Ala Cys 
    1055                 1060                 1065             


Ala Ser  Arg Asn Ile Val Asn  Tyr Leu Asn Asn Glu  Ser Ala Asn 
    1070                 1075                 1080             


Asn Pro  Lys Lys Arg Glu Asp  Leu Arg Arg Gln Leu  Cys Asp Lys 
    1085                 1090                 1095             


Asn Arg  Val Ile Arg Lys Pro  Trp Glu Thr Phe Thr  Gln Asp Ala 
    1100                 1105                 1110             


Tyr Asn  Ala Leu Glu Asn Val  Val Val Ser Phe Lys  Asn Tyr Val 
    1115                 1120                 1125             


Arg Val  Ile Asn Lys Ala Thr  Asn Arg Tyr Glu His  Tyr Asp Glu 
    1130                 1135                 1140             


Asn Gly  Lys Lys Arg Phe Val  Gln Gln Lys Gly Ser  Glu Leu Trp 
    1145                 1150                 1155             


Ala Ile  Arg Lys Pro Met His  Lys Glu Thr Tyr Tyr  Gly His Val 
    1160                 1165                 1170             


Asn Leu  Arg Arg Lys Glu Leu  Val Thr Leu Gln Lys  Ala Leu Asp 
    1175                 1180                 1185             


Asp Ile  Pro Ser Ile Cys Asp  Lys Lys Leu Arg Asp  Tyr Ile Ser 
    1190                 1195                 1200             


Ala Leu  Val Glu Lys His Phe  Asn Lys Arg Gln Leu  Leu Ala His 
    1205                 1210                 1215             


Phe Lys  Ser Thr Asp Tyr Tyr  Trp Gln Lys Gln Tyr  Val Asn Lys 
    1220                 1225                 1230             


Val Tyr  Val Trp Thr Phe Ser  Asp Asp Ile Lys Pro  Leu Val Ala 
    1235                 1240                 1245             


Thr Arg  Lys Leu Leu Asp Thr  Ser Phe Asp Ala Lys  Arg Ile Gly 
    1250                 1255                 1260             


Thr Ile  Thr Asp Thr Gly Ile  Gln Lys Ile Leu Arg  Asn Tyr Leu 
    1265                 1270                 1275             


Glu Ala  Lys Gly Gly Asn Ala  Thr Leu Ala Phe Thr  Pro Glu Gly 
    1280                 1285                 1290             


Ile Ala  Glu Met Asn Gln Asn  Ile Ser Lys Tyr Asn  Asp Gly Lys 
    1295                 1300                 1305             


Pro His  Gln Pro Ile Leu Lys  Val Arg Ile Thr Glu  Pro Met Gly 
    1310                 1315                 1320             


Ala Lys  Tyr Arg Val Gly Gln  Thr Gly Asn Lys Met  Ala Lys Tyr 
    1325                 1330                 1335             


Val Glu  Ala Gln Ser Gly Thr  Asn Leu Tyr Phe Ala  Ile Tyr Glu 
    1340                 1345                 1350             


Asp Ser  Glu Gly Lys Arg Ser  Tyr Thr Thr Val Pro  Leu Asp Glu 
    1355                 1360                 1365             


Val Ala  Glu Arg Leu Lys Gln  Arg Leu Ser Pro Val  Pro Glu Lys 
    1370                 1375                 1380             


Asp Glu  Asn Asp Val Pro Leu  Lys Phe Tyr Leu Ser  Pro Asn Asp 
    1385                 1390                 1395             


Leu Val  Tyr Val Pro Thr Glu  Glu Glu Leu Gln Leu  Arg Glu Cys 
    1400                 1405                 1410             


Lys Leu  Asn Lys Asp Arg Ile  Tyr Lys Met Val Ser  Ser Thr Gly 
    1415                 1420                 1425             


Asn Glu  Cys His Phe Ile Pro  Tyr Tyr Val Ala Asn  Val Ile Tyr 
    1430                 1435                 1440             


Asn Lys  Gly Gly Phe Asn Met  Gln Met His Arg Pro  Gln Ser 
    1445                 1450                 1455         


<210> 389
<211> 1218
<212> PRT
<213> Prevotella buccalis


<220>
<223> Prevotella buccalis ATCC 35310

<400> 389
Met Asn Lys Arg Ile Leu Gly Leu Asp Thr Gly Thr Asn Ser Leu Gly 
1               5                   10                  15      


Trp Ala Val Val Asp Trp Asp Glu His Ala Gln Ser Tyr Glu Leu Ile 
            20                  25                  30          


Lys Tyr Gly Asp Val Ile Phe Gln Glu Gly Val Lys Ile Glu Lys Gly 
        35                  40                  45              


Ile Glu Ser Ser Lys Ala Ala Glu Arg Ser Gly Tyr Lys Ala Ile Arg 
    50                  55                  60                  


Lys Gln Tyr Phe Arg Arg Arg Leu Arg Lys Ile Gln Val Leu Lys Val 
65                  70                  75                  80  


Leu Val Lys Tyr His Leu Cys Pro Tyr Leu Ser Asp Asp Asp Leu Arg 
                85                  90                  95      


Gln Trp His Leu Gln Lys Gln Tyr Pro Lys Ser Asp Glu Leu Met Leu 
            100                 105                 110         


Trp Gln Arg Thr Ser Asp Glu Glu Gly Lys Asn Pro Tyr Tyr Asp Arg 
        115                 120                 125             


His Arg Cys Leu His Glu Lys Leu Asp Leu Thr Val Glu Ala Asp Arg 
    130                 135                 140                 


Tyr Thr Leu Gly Arg Ala Leu Tyr His Leu Thr Gln Arg Arg Gly Phe 
145                 150                 155                 160 


Leu Ser Asn Arg Leu Asp Thr Ser Ala Asp Asn Lys Glu Asp Gly Val 
                165                 170                 175     


Val Lys Ser Gly Ile Ser Gln Leu Ser Thr Glu Met Glu Glu Ala Gly 
            180                 185                 190         


Cys Glu Tyr Leu Gly Asp Tyr Phe Tyr Lys Leu Tyr His Glu Gln Gly 
        195                 200                 205             


Asn Lys Val Arg Ile Arg Gln Arg Tyr Thr Asp Arg Lys Lys His Tyr 
    210                 215                 220                 


Gln His Glu Phe Asp Ala Ile Cys Glu Lys Gln Glu Leu Ser Ser Glu 
225                 230                 235                 240 


Leu Ile Glu Asp Leu Gln Arg Ala Ile Phe Phe Gln Leu Pro Leu Lys 
                245                 250                 255     


Ser Gln Arg His Gly Val Gly Arg Cys Thr Phe Glu Arg Gly Lys Pro 
            260                 265                 270         


Arg Cys Ala Asp Ser His Pro Asp Tyr Glu Glu Phe Arg Met Leu Cys 
        275                 280                 285             


Phe Val Asn Asn Ile Gln Val Lys Gly Pro His Asp Leu Glu Leu Arg 
    290                 295                 300                 


Pro Leu Thr Tyr Glu Glu Arg Glu Lys Ile Glu His Leu Phe Phe Arg 
305                 310                 315                 320 


Lys Ser Lys Pro Asn Phe Asp Phe Glu Asp Ile Ala Lys Glu Leu Ala 
                325                 330                 335     


Gly Lys Lys Asn Tyr Ala Trp Ile His Asp Lys Glu Glu Arg Ala Tyr 
            340                 345                 350         


Lys Phe Asn Tyr Arg Met Thr Gln Gly Val Pro Gly Cys Pro Thr Thr 
        355                 360                 365             


Ala Gln Leu Lys Ser Ile Phe Gly Asp Asp Trp Lys Thr Gly Ile Ala 
    370                 375                 380                 


Glu Thr Tyr Thr Leu Ile Gln Lys Lys Asn Gly Ser Lys Ser Leu Gln 
385                 390                 395                 400 


Glu Met Val Asp Asp Val Trp Asn Val Leu Tyr Ser Phe Ser Ser Val 
                405                 410                 415     


Glu Lys Leu Lys Glu Phe Ala His His Lys Leu Gln Leu Asp Glu Glu 
            420                 425                 430         


Asn Ala Glu Lys Phe Ala Lys Ile Lys Leu Ser His Ser Phe Ala Ala 
        435                 440                 445             


Leu Ser Leu Lys Ala Ile Arg Lys Phe Leu Pro Phe Leu Arg Lys Gly 
    450                 455                 460                 


Met Tyr Tyr Thr His Ala Ser Phe Phe Ala Asn Ile Pro Thr Ile Val 
465                 470                 475                 480 


Gly Lys Glu Ile Trp Asn Asn Glu Gln Ser Arg Lys Tyr Ile Met Glu 
                485                 490                 495     


Asn Val Gly Glu Leu Val Phe Asn Tyr Gln Pro Lys His Arg Asp Val 
            500                 505                 510         


Gln Gly Thr Ile Glu Met Leu Ile Lys Asp Phe Leu Ala Asn Asn Phe 
        515                 520                 525             


Glu Leu Pro Ala Gly Ala Thr Asp Lys Leu Tyr His Pro Ser Met Ile 
    530                 535                 540                 


Glu Thr Tyr Pro His Ala Leu Arg Asn Glu Phe Gly Ile Leu Gln Leu 
545                 550                 555                 560 


Gly Ser Pro Arg Thr Asn Ala Ile Arg Asn Pro Met Ala Met Arg Ser 
                565                 570                 575     


Leu His Val Leu Arg Arg Val Val Asn Gln Leu Leu Lys Glu Ser Ile 
            580                 585                 590         


Ile Asp Glu Asn Thr Glu Val His Val Glu Tyr Ala Arg Glu Leu Asn 
        595                 600                 605             


Asp Ala Asn Lys Arg Arg Ala Ile Ala Asp Arg Gln Lys Glu Gln Asp 
    610                 615                 620                 


Lys Gln His Lys Lys Tyr Gly Asp Glu Ile Arg Lys Leu Tyr Lys Glu 
625                 630                 635                 640 


Glu Thr Gly Lys Asp Ile Glu Pro Thr Gln Thr Asp Val Leu Lys Phe 
                645                 650                 655     


Gln Leu Trp Glu Glu Gln Asn His Tyr Cys Leu Tyr Thr Gly Glu Gln 
            660                 665                 670         


Ile Gly Ile Thr Asp Phe Ile Gly Ser Asn Pro Lys Phe Asp Ile Glu 
        675                 680                 685             


His Thr Ile Pro Gln Ser Val Gly Gly Asp Ser Thr Gln Met Asn Leu 
    690                 695                 700                 


Thr Leu Cys Asp Asn Arg Phe Asn Arg Glu Val Lys Lys Ala Lys Leu 
705                 710                 715                 720 


Pro Thr Glu Leu Ala Asn His Glu Glu Ile Leu Thr Arg Ile Glu Pro 
                725                 730                 735     


Trp Lys Asn Lys Tyr Glu Gln Leu Val Lys Glu Arg Asp Lys Gln Arg 
            740                 745                 750         


Thr Phe Ala Gly Met Asp Lys Ala Val Lys Asp Ile Arg Ile Gln Lys 
        755                 760                 765             


Arg His Lys Leu Gln Met Glu Ile Asp Tyr Trp Arg Gly Lys Tyr Glu 
    770                 775                 780                 


Arg Phe Thr Met Thr Glu Val Pro Glu Gly Phe Ser Arg Arg Gln Gly 
785                 790                 795                 800 


Thr Gly Ile Gly Leu Ile Ser Arg Tyr Ala Gly Leu Tyr Leu Lys Ser 
                805                 810                 815     


Leu Phe His Gln Ala Asp Ser Arg Asn Lys Ser Asn Val Tyr Val Val 
            820                 825                 830         


Lys Gly Val Ala Thr Ala Glu Phe Arg Lys Met Trp Gly Leu Gln Ser 
        835                 840                 845             


Glu Tyr Glu Lys Lys Cys Arg Asp Asn His Ser His His Cys Met Asp 
    850                 855                 860                 


Ala Ile Thr Ile Ala Cys Ile Gly Lys Arg Glu Tyr Asp Leu Met Ala 
865                 870                 875                 880 


Glu Tyr Tyr His Met Glu Glu Thr Phe Arg Gln Gly Arg Gly Ser Lys 
                885                 890                 895     


Pro Lys Phe Ser Lys Pro Trp Ala Thr Phe Thr Glu Asp Val Leu Asn 
            900                 905                 910         


Ile Tyr Lys Asn Leu Leu Val Val His Asp Thr Pro Asn Asn Met Pro 
        915                 920                 925             


Lys His Thr Lys Lys Tyr Val Gln Thr Ser Lys Gly Lys Val Leu Ala 
    930                 935                 940                 


Gln Gly Asp Thr Ala Arg Gly Ser Leu His Leu Asp Thr Tyr Tyr Gly 
945                 950                 955                 960 


Ala Ile Glu Arg Asp Gly Glu Ile Arg Tyr Val Val Arg Arg Pro Leu 
                965                 970                 975     


Ser Ser Phe Thr Asn Pro Lys Glu Leu Glu Asn Ile Val Asp Glu Thr 
            980                 985                 990         


Val Lys Arg Thr Ile Lys Glu Ala  Ile Ala Asp Lys Asn  Phe Lys Gln 
        995                 1000                 1005             


Ala Ile  Ala Glu Pro Ile Tyr  Met Asn Glu Asp Lys  Gly Ile Leu 
    1010                 1015                 1020             


Ile Lys  Lys Val Arg Cys Phe  Ala Asn Ser Val Lys  Gln Pro Ile 
    1025                 1030                 1035             


Asn Ile  Arg Gln His Arg Asp  Leu Ser Lys Lys Glu  Tyr Lys Gln 
    1040                 1045                 1050             


Gln Tyr  His Val Met Asn Glu  Asn Asn Tyr Leu Leu  Ala Ile Tyr 
    1055                 1060                 1065             


Glu Gly  Leu Val Lys Asn Lys  Val Val Arg Glu Phe  Glu Ile Val 
    1070                 1075                 1080             


Ser Tyr  Ile Glu Ala Ala Lys  Tyr Tyr Lys Arg Ser  Gln Asp Arg 
    1085                 1090                 1095             


Asn Ile  Phe Ser Ser Ile Val  Pro Thr His Ser Thr  Lys Tyr Gly 
    1100                 1105                 1110             


Leu Pro  Leu Lys Thr Lys Leu  Leu Met Gly Gln Gln  Val Leu Met 
    1115                 1120                 1125             


Phe Glu  Glu Asn Pro Asp Glu  Ile Gln Val Asp Asn  Thr Lys Asp 
    1130                 1135                 1140             


Leu Val  Lys Arg Leu Tyr Lys  Val Val Gly Ile Glu  Lys Asp Gly 
    1145                 1150                 1155             


Arg Ile  Lys Phe Lys His His  Gln Glu Ala Arg Lys  Glu Gly Leu 
    1160                 1165                 1170             


Thr Ile  Tyr Ser Thr Pro Tyr  Lys Asn Asn Asp Asp  Tyr Val Pro 
    1175                 1180                 1185             


Ile Phe  Arg Gln Ser Ile Lys  Asn Ile Asn Ile Leu  Val Asp Gly 
    1190                 1195                 1200             


Ile Asp  Phe Asn Ile Asp Ile  Leu Gly Lys Val Thr  Leu Lys Glu 
    1205                 1210                 1215             


<210> 390
<211> 1422
<212> PRT
<213> Prevotella denticola


<220>
<223> Prevotella denticola CRIS 18C-A

<400> 390
Met Thr Gln Lys Val Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly 
1               5                   10                  15      


Ser Ser Val Arg Asn Leu Asp Leu Ser Asp Asp Leu Lys Gly Gln Leu 
            20                  25                  30          


Glu Phe Phe Ser Ser Asp Ile Phe Arg Ser Ser Val Asn Lys Glu Ser 
        35                  40                  45              


Asn Gly Arg Glu Tyr Ser Leu Ala Ala Gln Arg Ser Ala His Ser Arg 
    50                  55                  60                  


Ser Arg Gly Leu Asn Glu Ala Arg Arg Arg Lys Leu Trp Ala Thr Leu 
65                  70                  75                  80  


Asp Leu Leu Ile Lys Tyr Gly Phe Cys Pro Met Ser Pro Glu Ser Leu 
                85                  90                  95      


Met Arg Trp Arg Thr Tyr Asp Lys Gln Arg Gly Leu Phe Arg Glu Tyr 
            100                 105                 110         


Pro Ile Asp Asp Lys Asn Phe Asn Ala Trp Ile Leu Leu Asp Phe Asp 
        115                 120                 125             


Gly Asp Gly Lys Pro Asp Tyr Ser Ser Pro Tyr Gln Leu Arg Arg Glu 
    130                 135                 140                 


Leu Val Ile Arg Gln Phe Asp Phe Asp Gln Pro Ile Glu Arg Tyr Lys 
145                 150                 155                 160 


Leu Gly Arg Ala Leu Tyr His Ile Ala Gln His Arg Gly Phe Lys Ser 
                165                 170                 175     


Ser Lys Gly Glu Thr Leu Ser Gln Gln Glu Thr Asn Ser Lys Gln Ser 
            180                 185                 190         


Leu Thr Asp Asp Thr Ala Asp Val Ala Gly Glu Met Lys Ala Ser Glu 
        195                 200                 205             


Glu Lys Leu Ser Lys Gly Leu Ser Thr Tyr Met Lys Glu Asn Asn Leu 
    210                 215                 220                 


Leu Thr Val Gly Ala Ala Phe Ala Gln Leu Glu Asp Glu Gly Val Arg 
225                 230                 235                 240 


Val Arg Asn Asn Asn Asp Tyr Arg Ala Ile Arg Ser Gln Phe Gln Arg 
                245                 250                 255     


Glu Ile Glu Thr Ile Phe Lys Phe Gln Gln Gly Leu Ser Val Glu Asn 
            260                 265                 270         


Glu Leu Tyr Glu Arg Leu Val Ser Glu Lys Lys Asn Ile Gly Thr Ile 
        275                 280                 285             


Phe Tyr Lys Arg Pro Leu Arg Ser Gln Arg Gly Asn Val Gly Lys Cys 
    290                 295                 300                 


Thr Leu Glu Arg Thr Lys Pro Arg Cys Ala Ile Gly His Pro Leu Phe 
305                 310                 315                 320 


Glu Lys Phe Arg Ala Trp Thr Leu Ile Asn Asn Ile Lys Val Arg Met 
                325                 330                 335     


Ser Glu Glu Glu Gln Ala Glu Gln Leu Pro Met Lys Leu Arg Phe Glu 
            340                 345                 350         


Leu Tyr Asn Asp Cys Phe Leu Ala Phe Val Arg Ala Glu Phe Lys Phe 
        355                 360                 365             


Glu Asp Ile Arg Lys Tyr Leu Glu Lys Arg Leu Gly Val His Phe Ser 
    370                 375                 380                 


Tyr Asn Asp Lys Thr Ile Asn Tyr Lys Asp Ser Thr Ser Val Ala Gly 
385                 390                 395                 400 


Cys Pro Ile Thr Ala Arg Phe Arg Lys Leu Leu Gly Glu Asp Trp Glu 
                405                 410                 415     


Ser Phe His Val Asp Gly Gln Lys Gln Arg Gln Ala His Gly Lys Asn 
            420                 425                 430         


Asn Ala Ser Phe His Thr Val Ser Tyr Ser Thr Asn Asp Ile Trp His 
        435                 440                 445             


Phe Cys Tyr Asp Ala Glu Glu Pro Glu Ala Val Leu Ser Phe Ala Gln 
    450                 455                 460                 


Asp Asn Leu Lys Trp Glu Lys Lys Lys Ala Glu Glu Leu Val Arg Ile 
465                 470                 475                 480 


Trp Ser Ala Ile Pro Gln Gly Tyr Ala Met Leu Ser Gln Lys Ala Ile 
                485                 490                 495     


Arg Asn Ile Asn Lys Met Leu Ile Leu Gly Leu Lys Tyr Ser Asp Ala 
            500                 505                 510         


Val Leu Leu Ala Lys Val Pro Glu Ile Val Glu Ile Thr Asp Gly Glu 
        515                 520                 525             


Ile Leu Ser Val Thr Glu Asp Tyr His Arg Val Glu Ala Gln Val Gly 
    530                 535                 540                 


Tyr Glu Lys Gln Ile Asn Asn Ile Val Asn Ala Leu Ile Ala Lys Tyr 
545                 550                 555                 560 


Lys Ser Ala Ser Glu Glu Tyr Arg Phe Ala Asp His Asn Tyr Glu Tyr 
                565                 570                 575     


Gln Leu Asp Lys Ser Asp Glu Lys Asp Ile Ile Lys Gln Ile Glu Ser 
            580                 585                 590         


Asn Ile Gly Thr Arg Lys Trp Ser Leu Leu Asp Ala Asp Glu Gln Thr 
        595                 600                 605             


Asp Ile Leu Gln Lys Val Arg Asp Lys Tyr Gln Asn Phe Phe Arg Ser 
    610                 615                 620                 


His Glu Arg Lys Phe Val Glu Ser Pro Lys Leu Gly Glu Cys Phe Glu 
625                 630                 635                 640 


Glu Tyr Leu Met Lys Lys Phe Pro Met Val Glu Gly Glu Arg Trp Lys 
                645                 650                 655     


Lys Leu Tyr His Pro Ser Gln Ile Ala Ile Tyr Arg Pro Val Pro Ala 
            660                 665                 670         


Asn Lys Asp Arg Ser Ala Leu Arg Leu Gly Asn Pro Asp Ile Gly Ala 
        675                 680                 685             


Ile Lys Asn Pro Thr Val Leu Arg Val Leu Asn Thr Leu Arg Lys Arg 
    690                 695                 700                 


Val Asn Gln Leu Leu Asp Asp Gly Ile Ile Ser Pro Asp Glu Thr Arg 
705                 710                 715                 720 


Val Val Val Glu Thr Ala Arg Glu Leu Asn Asp Ala Asn Arg Lys Trp 
                725                 730                 735     


Ala Leu Asp Thr Tyr Asn Arg Ile Arg His Asp Glu Asn Glu Lys Ile 
            740                 745                 750         


Lys Lys Ile Leu Ala Glu Phe Tyr Pro Lys Arg Asp Asn Ile Ser Thr 
        755                 760                 765             


Val Asp Ile Asp Lys Ala Arg Tyr Val Ile Asp Gln Arg Glu Met Asp 
    770                 775                 780                 


Tyr Phe Thr Glu Ala Lys Thr Tyr His Lys Asp Ile Lys Lys Tyr Lys 
785                 790                 795                 800 


Leu Trp Leu Glu Gln Gly Gly Gln Cys Met Tyr Thr Gly Arg Thr Ile 
                805                 810                 815     


Asn Leu Ser Asn Leu Phe Asp Pro Asn Ser Phe Asp Val Glu His Thr 
            820                 825                 830         


Ile Pro Glu Ser Ile Ser Phe Asp Ser Ser Asp Met Asn Leu Thr Leu 
        835                 840                 845             


Cys Asp Ala His Tyr Asn Arg Phe Ile Lys Lys Asn His Ile Pro Ala 
    850                 855                 860                 


Asp Leu Pro Asn Tyr Asp Lys Ser Val Val Ile Asp Gly Lys Glu Tyr 
865                 870                 875                 880 


Ser Pro Ile Lys Pro Arg Leu Gln Arg Trp Ala Asp Arg Val Glu Arg 
                885                 890                 895     


Leu Asn Arg Asn Val Glu Tyr Trp Arg Gly Gln Ala Arg Arg Ala Gln 
            900                 905                 910         


Asn Lys Asp Arg Lys Asp Gln Cys Met Arg Glu Met His Leu Trp Lys 
        915                 920                 925             


Met Glu Leu Glu Tyr Trp Thr Lys Lys Leu Glu Arg Phe Thr Ile Thr 
    930                 935                 940                 


Glu Val Thr Asp Glu Phe Lys Asn Ser Gln Leu Val Asp Thr Arg Val 
945                 950                 955                 960 


Ile Thr Arg His Ala Val Leu Tyr Leu Lys Ser Ile Phe Pro His Val 
                965                 970                 975     


Asp Val Gln Arg Gly Asp Val Thr Ala Lys Phe Arg Lys Ile Leu Gly 
            980                 985                 990         


Ile Gln Ser Val Asp Glu Lys Lys  Asp Arg Ser Leu His  Ser His His 
        995                 1000                 1005             


Ala Ile  Asp Ala Thr Thr Leu  Thr Ile Ile Pro Gly  Ala Ala Lys 
    1010                 1015                 1020             


Arg Glu  Arg Met Leu Glu Leu  Phe Ala Lys Ile Glu  Glu Val Asn 
    1025                 1030                 1035             


Lys Met  Leu Ser Phe Ser Gly  Asn Glu Asp Arg Thr  Gly Leu Lys 
    1040                 1045                 1050             


Gln Glu  Leu Asp Gly Leu Lys  Asn Gln Leu Asn Lys  Glu Val Lys 
    1055                 1060                 1065             


Ala Cys  Arg Ile Gly His Asn  Val Ser Glu Ile Gly  Thr Phe Ile 
    1070                 1075                 1080             


Asn Asp  Asn Ile Ile Ile Asn  His His Val Lys Asn  Gln Ala Leu 
    1085                 1090                 1095             


Thr Pro  Val Arg Arg Arg Leu  Arg Lys Arg Gly His  Ile Val Gly 
    1100                 1105                 1110             


Gly Met  Asp Asn Pro Arg Trp  Gln Thr Gly Asp Ala  Leu Arg Gly 
    1115                 1120                 1125             


Glu Ile  His Lys Ala Ser Tyr  Tyr Gly Ala Ile Thr  Gln Tyr Ala 
    1130                 1135                 1140             


Lys Asp  Lys Glu Gly Lys Val  Leu Met Lys Glu Gly  Arg Pro Gln 
    1145                 1150                 1155             


Ile Asn  Pro Thr Ile Lys Phe  Val Ile Arg Arg Glu  Leu Lys Tyr 
    1160                 1165                 1170             


Lys Lys  Ser Ser Thr Asp Ser  Gly Phe Ala Ser Trp  Asp Asp Leu 
    1175                 1180                 1185             


Gly Lys  Ala Ile Val Asp Lys  Glu Leu Phe Ala Leu  Met Lys Gly 
    1190                 1195                 1200             


Gln Phe  Pro Glu Gly Thr Ser  Phe Lys Asp Ala Cys  Glu Gln Gly 
    1205                 1210                 1215             


Ile Tyr  Met Ile Lys Lys Gly  Lys Asn Gly Glu Val  Asp Thr Lys 
    1220                 1225                 1230             


Leu Tyr  Arg Ile Arg His Ile  Arg Cys Lys Thr Lys  Gln Lys Asn 
    1235                 1240                 1245             


Ala Leu  Lys Ile Lys Glu Gln  Ala Tyr Lys Ser Glu  Lys Glu Tyr 
    1250                 1255                 1260             


Lys Arg  Tyr Phe Tyr Ala Ala  Val Gly Asp Leu Tyr  Ala Met Cys 
    1265                 1270                 1275             


Cys Tyr  Thr Asn Gly Lys Thr  Arg Glu Phe Lys Ile  Tyr Ser Leu 
    1280                 1285                 1290             


Tyr Asp  Ile Ser Cys His Arg  Lys Val Gly Val Glu  Asp Ile Pro 
    1295                 1300                 1305             


Glu Phe  Ile Thr Asp Lys Lys  Gly Asn Arg Leu Met  Leu Asp Tyr 
    1310                 1315                 1320             


Lys Leu  His Thr Gly Asp Met  Ile Leu Leu Tyr Lys  Glu Asn Pro 
    1325                 1330                 1335             


Glu Glu  Leu Tyr Asp Leu Asp  Asn Val Ser Leu Ser  Lys Leu Leu 
    1340                 1345                 1350             


Tyr Lys  Ile Asn Gly Phe Glu  Asn Asp Gly Leu Arg  Ile Arg Met 
    1355                 1360                 1365             


Val Asn  His Leu Val Ala Lys  Glu Ala Met Gly Glu  Ser Val Lys 
    1370                 1375                 1380             


Asp Tyr  Ala Lys Leu Pro Asp  Ile Ile Arg Cys Gly  Val Lys Thr 
    1385                 1390                 1395             


Ile Lys  Phe Leu Val Met Gly  Glu Asn Arg Asp Phe  Val Ile Lys 
    1400                 1405                 1410             


Asn Gly  Lys Ile Ser Phe Asn  His Arg 
    1415                 1420         


<210> 391
<211> 1375
<212> PRT
<213> Prevotella histicola


<220>
<223> Prevotella histicola F0411

<400> 391
Met Lys Lys Ile Leu Gly Leu Asp Leu Gly Thr Thr Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Tyr Glu Ser Glu Asn Thr Asp Glu Lys Ser Ser Ile Val 
            20                  25                  30          


Arg Leu Gly Val Arg Val Asn Pro Leu Ser Val Asp Glu Lys Gly Asn 
        35                  40                  45              


Phe Glu Lys Gly Lys Ala Ile Thr Thr Asn Ala Asp Arg Gln Gln Thr 
    50                  55                  60                  


His Gly Ala Arg Ile Asn Leu Gln Arg Tyr Lys Leu Arg Arg Glu Asn 
65                  70                  75                  80  


Leu Lys Asp Cys Leu Gln Lys Gln Gly Trp Ile Gly Thr Glu Ala Leu 
                85                  90                  95      


Cys Glu Glu Gly Lys Thr Ser Thr Phe Glu Thr Tyr Met Leu Arg Ala 
            100                 105                 110         


Lys Ala Ala Glu Glu Glu Ile Ser Leu His Glu Leu Cys Arg Val Leu 
        115                 120                 125             


Phe Met Met Asn Lys Lys Arg Gly Tyr Lys Ser Asn Arg Lys Ala Asn 
    130                 135                 140                 


Asn Lys Glu Asp Gly Lys Leu Phe Asp Gly Met Thr Val Ala Lys Lys 
145                 150                 155                 160 


Leu Tyr Glu Glu His Leu Thr Pro Ala Glu Tyr Ser Phe Gln Leu Leu 
                165                 170                 175     


Ser Ser Gly Lys Lys Phe Lys Gln Glu Tyr Tyr Arg Ser Asp Leu Lys 
            180                 185                 190         


Glu Glu Phe Asp Arg Ile Trp Asn Glu Gln Gln Lys Tyr Tyr Pro Glu 
        195                 200                 205             


Ile Leu Thr Asp Asp Phe Lys Gln Gln Leu Gln Gly Lys Ser Lys Gly 
    210                 215                 220                 


Asn Thr Ser Lys Ile Phe Leu Gly Lys Tyr Gly Ile Tyr Ser Ala Asp 
225                 230                 235                 240 


Leu Lys Gly Leu Asp Arg Lys Leu Gln Pro Leu Lys Trp Arg Val Glu 
                245                 250                 255     


Ala Leu Lys Gln Gln Val Asp Lys Glu Val Leu Ala Phe Val Ile Ser 
            260                 265                 270         


Asp Leu Asn Gly Gln Ile Ala Ser Thr Ser Gly Leu Leu Gly Ala Ile 
        275                 280                 285             


Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Lys Gln Thr Val Gly Gln 
    290                 295                 300                 


Tyr Leu Trp Thr Ser Leu Lys Glu Thr Pro His Val Ser Ile Lys Asn 
305                 310                 315                 320 


Lys Pro Phe Tyr Arg Gln Asp Tyr Leu Asp Glu Phe Glu Lys Ile Trp 
                325                 330                 335     


Glu Thr Gln Ala Thr Tyr His Lys Glu Leu Thr Pro Glu Leu Lys Gln 
            340                 345                 350         


Glu Ile Arg Asp Ile Ile Ile Phe Tyr Gln Arg Pro Leu Lys Ser Lys 
        355                 360                 365             


Lys Gly Leu Ile Ser Val Cys Glu Leu Glu Gln Arg Lys Val Lys Val 
    370                 375                 380                 


Thr Ile Asp Gly Lys Glu Lys Glu Ile Ser Ile Gly Pro Lys Val Ala 
385                 390                 395                 400 


Pro Lys Ser Ser Pro Met Phe Gln Glu Phe Arg Ile Trp Gln Asn Leu 
                405                 410                 415     


Asn Asn Ile Leu Leu Ile Asp Lys Gly Asn Asn Ser Ile His Pro Leu 
            420                 425                 430         


Tyr Glu Glu Glu Lys Asn Leu Leu Tyr Glu Glu Leu Ser Val Lys Glu 
        435                 440                 445             


Lys Leu Ser Lys Ala Glu Ala Leu Lys Val Leu Asn Lys Asn Ser Lys 
    450                 455                 460                 


Gln Trp Asp Leu Asn Tyr Lys Glu Ile Glu Gly Asn Arg Thr Gln Ala 
465                 470                 475                 480 


Val Leu Tyr Asp Cys Tyr Asn Arg Ile Ile Val Met Thr Gly His Glu 
                485                 490                 495     


Glu Tyr Asn Phe Lys Lys Leu Lys Ala Ser Glu Ile Arg Ser Tyr Val 
            500                 505                 510         


Lys Thr Thr Phe Thr Gly Leu Gly Phe Asn Thr Asp Ile Leu Glu Phe 
        515                 520                 525             


Asp Ser Ser Leu Thr Gly His Glu Leu Glu Lys Gln Pro Met Tyr Gln 
    530                 535                 540                 


Leu Trp His Leu Leu Tyr Ser Tyr Glu Ser Asp Asn Ser Arg Thr Gly 
545                 550                 555                 560 


Asn Asp Ala Leu Leu Arg Lys Leu Glu Thr Ala Phe Gly Phe Pro Lys 
                565                 570                 575     


Glu Tyr Ala Ala Val Leu Ser Asp Val Val Phe Glu Asp Ser Tyr Gly 
            580                 585                 590         


Asn Leu Ser Val Lys Ala Met Arg Lys Ile Leu Pro His Leu Gln Ala 
        595                 600                 605             


Gly Leu Asn Tyr Ser Gln Ala Cys Glu Glu Ala Gly Tyr Lys His Ser 
    610                 615                 620                 


Arg Arg Ser Leu Thr Lys Asn Glu Leu Asp Gln Lys Glu Tyr Lys Glu 
625                 630                 635                 640 


Lys Leu Glu Leu Leu Pro Lys Asn Ser Leu His Asn Pro Val Val Glu 
                645                 650                 655     


Lys Ile Leu Asn Gln Met Ile Asn Val Ile Asn Ala Val Ile Asp Glu 
            660                 665                 670         


Tyr Gly Lys Pro Asp Glu Ile Arg Ile Glu Leu Ala Arg Glu Leu Lys 
        675                 680                 685             


Ile Gly Ala Ala Glu Arg Glu Asn Met Thr Arg Ser Ile Asn Gln Gly 
    690                 695                 700                 


Asn Ala Glu Asn Lys Arg Ile Arg Glu Ile Leu Glu Lys Glu Phe Ala 
705                 710                 715                 720 


Leu Ser Tyr Ile Ser Arg Asn Asp Ile Ile Lys Tyr Lys Leu Tyr Glu 
                725                 730                 735     


Glu Leu Lys Ser Asn Gly Phe Lys Thr Leu Tyr Ser Asp Thr Tyr Ile 
            740                 745                 750         


Ser Lys Asp Lys Leu Phe Ser Lys Asp Phe Asp Ile Glu His Ile Ile 
        755                 760                 765             


Pro Lys Ala Arg Leu Phe Asp Asp Ser Leu Ser Asn Lys Thr Ile Glu 
    770                 775                 780                 


Ala Arg Asp Val Asn Ile Ala Lys Ser Asn Lys Thr Ala Phe Asp Phe 
785                 790                 795                 800 


Ile Ser Glu Lys Tyr Asp Gln Gln Gly Ile Glu Ala Tyr Lys Lys Lys 
                805                 810                 815     


Leu Asp Ile Leu Leu Gln Asp Gly Ser Ile Ser Lys Ala Lys Tyr Asn 
            820                 825                 830         


Arg Leu Leu Met Lys Glu Ala Asp Ile Pro Ser Gly Phe Ile Asp Arg 
        835                 840                 845             


Asp Leu Arg Asp Thr Gln Tyr Ile Ala Lys Lys Ala Tyr Glu Ile Leu 
    850                 855                 860                 


Ser Asp Leu Val Arg Asn Val Thr Pro Thr Thr Gly Ala Val Thr Ser 
865                 870                 875                 880 


Arg Leu Arg Glu Asp Trp Gln Leu Val Asp Val Met Lys Glu Leu Asn 
                885                 890                 895     


Phe Glu Lys Tyr Gln Lys Leu Gly Leu Val Glu Val Ile Glu Asp Arg 
            900                 905                 910         


Asp Gly Arg Lys Ile Lys Arg Ile Lys Asp Trp Thr Lys Arg Asn Asp 
        915                 920                 925             


His Arg His His Ala Met Asp Ala Leu Thr Ile Ala Phe Thr Lys Pro 
    930                 935                 940                 


Ser Tyr Ile Gln Tyr Leu Asn Asn Leu Asn Ala Arg Ser Asp Lys Asn 
945                 950                 955                 960 


Ser Ser Ile Tyr Gly Ile Glu Asn Lys Glu Leu His Arg Glu Asp Asn 
                965                 970                 975     


Lys Leu Arg Phe Asn Ala Pro Leu Pro Ile Asn Glu Phe Arg Ala Glu 
            980                 985                 990         


Ala Arg Arg His Leu Lys Ser Ile  Leu Val Ser Val Lys  Ala Lys Asn 
        995                 1000                 1005             


Lys Val  Met Thr Gln Asn Val  Asn Val Ile Lys Thr  Lys His Gly 
    1010                 1015                 1020             


Val Ile  Lys Lys Val Gln Leu  Thr Pro Arg Gly Glu  Leu His Asn 
    1025                 1030                 1035             


Ala Thr  Phe Tyr Gly Thr Lys  Lys Arg Pro Ile Ile  Lys Met Val 
    1040                 1045                 1050             


Lys Val  Gly Ala Ala Leu Asp  Glu Val Thr Ile Lys  Lys Val Ser 
    1055                 1060                 1065             


Ser Ser  Phe Ile Arg Glu Ala  Leu Leu Asp Arg Leu  His Glu Tyr 
    1070                 1075                 1080             


Asn Gly  Asp Ala Lys Lys Ala  Phe Thr Gly Arg Asn  Ser Ile Asp 
    1085                 1090                 1095             


Lys Asn  Pro Ile Tyr Ile Asp  Glu Glu His Lys Lys  Thr Val Pro 
    1100                 1105                 1110             


Ala Leu  Val Lys Thr Ile Glu  Trp Glu Met Tyr His  Pro Thr Arg 
    1115                 1120                 1125             


Lys Leu  Ile Ser Pro Asp Leu  Lys Ile Asp Lys Val  Ile Asp Lys 
    1130                 1135                 1140             


Gly Ile  Arg Glu Ile Leu Lys  Thr Arg Leu Ala Lys  Phe Asn Gly 
    1145                 1150                 1155             


Asp Ala  Gln Lys Ala Phe Ser  Asn Leu Asp Glu Asn  Pro Ile Tyr 
    1160                 1165                 1170             


Lys Asp  Glu Ala Lys Lys Ile  Thr Leu Lys Arg Val  Ser Leu Glu 
    1175                 1180                 1185             


Gly Val  Ser Ser Val Ile Pro  Leu His Thr Leu Lys  Asp Arg Glu 
    1190                 1195                 1200             


Gly Lys  Leu Val Val Gly Lys  Asp Gly Lys Pro Val  Leu Gly Asp 
    1205                 1210                 1215             


Tyr Val  Gln Thr Ser Asn Asn  His His Ile Ala Phe  Tyr Met Asp 
    1220                 1225                 1230             


Glu Asn  Gly Asn Leu Gln Asp  Asn Val Val Ser Phe  Phe Glu Ala 
    1235                 1240                 1245             


Ala Glu  Arg Lys Ser Gln Gly  Val Pro Val Ile Asp  Lys Asn Tyr 
    1250                 1255                 1260             


Asn His  Asp Lys Gly Trp Asn  Phe Leu Phe Thr Met  Lys Gln Asn 
    1265                 1270                 1275             


Glu Tyr  Phe Val Phe Pro Asn  Glu Val Thr Gly Phe  Asn Pro Ser 
    1280                 1285                 1290             


Glu Val  Asp Leu Met Asp Glu  Ala Asn Tyr Ser Ile  Ile Ser Pro 
    1295                 1300                 1305             


Asn Leu  Tyr Arg Val Gln Lys  Met Ser Lys Ala Ser  Gly Arg Asp 
    1310                 1315                 1320             


Tyr Trp  Phe Arg His His Leu  Glu Ala Met Leu Asn  Asp Asp Pro 
    1325                 1330                 1335             


Lys Leu  Arg Asn Ser Met Phe  Lys Arg Ile Thr Ser  Leu Lys Ala 
    1340                 1345                 1350             


Leu Glu  Gly Ile Val Lys Val  Arg Ile Asn Cys Ile  Gly Lys Ile 
    1355                 1360                 1365             


Val Ala  Val Gly Glu Tyr Asp  
    1370                 1375 


<210> 392
<211> 1380
<212> PRT
<213> Prevotella intermedia

<400> 392
Met Lys Arg Ile Leu Gly Leu Asp Leu Gly Thr Thr Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Asn Glu Ala Glu Asn Asn Asn Glu Ala Ser Ser Ile Val 
            20                  25                  30          


Arg Leu Gly Val Arg Val Asn Pro Leu Thr Val Asp Glu Lys Ser Asn 
        35                  40                  45              


Phe Glu Lys Gly Lys Ala Ile Thr Thr Asn Ala Asp Arg Gln Leu Arg 
    50                  55                  60                  


His Gly Ala Arg Ile Asn Leu Gln Arg Tyr Lys Leu Arg Arg Gln Asn 
65                  70                  75                  80  


Leu His Asp Cys Leu Gln Lys Gln Gly Trp Leu Gly Thr Glu Ala Met 
                85                  90                  95      


Tyr Glu Glu Gly Lys Ala Ser Thr Phe Glu Thr Tyr Lys Leu Arg Ala 
            100                 105                 110         


Lys Ala Ala Glu Glu Glu Ile Ser Leu His Glu Phe Ala Arg Val Leu 
        115                 120                 125             


Phe Met Leu Asn Lys Lys Arg Gly Tyr Lys Ser Asn Arg Lys Ala Asn 
    130                 135                 140                 


Asn Lys Glu Asp Gly Gln Leu Phe Asp Gly Met Thr Ile Ala Lys Lys 
145                 150                 155                 160 


Leu Tyr Glu Glu His Leu Thr Pro Ala Glu Tyr Ser Leu Gln Leu Leu 
                165                 170                 175     


Asn Lys Gly Lys Lys Phe Thr Gln Gly Tyr Tyr Arg Ser Asp Leu Asn 
            180                 185                 190         


Ala Glu Leu Glu Arg Ile Trp Asp Glu Gln Lys Lys Tyr Tyr Pro Glu 
        195                 200                 205             


Ile Leu Thr Asp Glu Phe Lys Gln Gln Leu Glu Gly Lys Thr Lys Thr 
    210                 215                 220                 


Asn Thr Ser Lys Ile Phe Leu Ala Lys Tyr Gly Ile Tyr Ser Ala Asp 
225                 230                 235                 240 


Leu Lys Gly Leu Asp Arg Lys Phe Gln Pro Leu Lys Trp Arg Val Glu 
                245                 250                 255     


Ala Leu Gln Gln Gln Val Asp Lys Glu Val Leu Ala Phe Val Ile Ser 
            260                 265                 270         


Asp Leu Lys Gly Gln Ile Ala Asn Thr Ser Gly Leu Leu Gly Ala Ile 
        275                 280                 285             


Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Lys Gln Thr Val Gly Gln 
    290                 295                 300                 


Tyr Leu Trp Ala Ser Leu Glu Glu Asn Pro His Ile Ser Ile Lys Asn 
305                 310                 315                 320 


Lys Pro Phe Tyr Arg Gln Asp Tyr Leu Asp Glu Phe Glu Lys Ile Trp 
                325                 330                 335     


Glu Thr Gln Ala Ala Phe His Lys Gln Leu Thr Pro Glu Leu Lys Gln 
            340                 345                 350         


Glu Ile Arg Asp Ile Ile Ile Phe Tyr Gln Arg Pro Leu Lys Ser Lys 
        355                 360                 365             


Lys Ser Leu Ile Ser Val Cys Glu Leu Glu Gln Arg Lys Val Lys Ala 
    370                 375                 380                 


Thr Ile Asp Gly Lys Glu Lys Glu Ile Thr Ile Gly Pro Lys Val Ala 
385                 390                 395                 400 


Pro Lys Ser Ser Pro Val Phe Gln Glu Phe Arg Ile Trp Gln Asn Leu 
                405                 410                 415     


Asn Asn Val Leu Leu Ile Asp Asn Asp Thr Asn Glu Lys Arg Pro Leu 
            420                 425                 430         


Asp Glu Val Glu Arg Asn Leu Leu Tyr Lys Glu Leu Ser Ile Lys Ala 
        435                 440                 445             


Lys Leu Ser Lys Thr Glu Ala Leu Lys Ile Leu Asn Lys Lys Gly Lys 
    450                 455                 460                 


Gln Trp Asp Leu Asn Tyr Arg Glu Leu Glu Gly Asn Arg Thr Gln Ala 
465                 470                 475                 480 


Ile Leu Phe Asp Cys Tyr Asn Arg Ile Ile Thr Leu Thr Gly His Glu 
                485                 490                 495     


Glu Cys Asp Phe Lys Lys Ile Lys Ala Ser Glu Ile Arg His Tyr Val 
            500                 505                 510         


Ser Thr Ile Phe Lys Asn Leu Gly Phe Ser Thr Glu Ile Leu Asp Phe 
        515                 520                 525             


Asp Pro Ser Leu Lys Lys His Glu Leu Glu Lys Gln Pro Met Tyr Gln 
    530                 535                 540                 


Leu Trp His Leu Leu Tyr Ser Tyr Glu Ser Asp Asn Ser Arg Thr Gly 
545                 550                 555                 560 


Asn Glu Ser Leu Leu Arg Lys Leu Glu Thr Thr Phe Gly Phe Pro Glu 
                565                 570                 575     


Glu Tyr Ala Thr Val Leu Cys Asp Val Val Phe Glu Glu Asp Tyr Gly 
            580                 585                 590         


Asn Leu Ser Val Lys Ala Met Arg Glu Ile Leu Pro Tyr Leu Gln Ala 
        595                 600                 605             


Gly Asn Asp Tyr Ser Gln Ala Cys Ala Tyr Ala Gly Tyr Asn His Ser 
    610                 615                 620                 


Arg His Ser Leu Thr Lys Glu Glu Leu Asp Gln Lys Val Tyr Lys Glu 
625                 630                 635                 640 


Arg Leu Glu Leu Leu Pro Lys Asn Ser Leu Arg Asn Pro Val Val Glu 
                645                 650                 655     


Lys Ile Leu Asn Gln Met Ile Asn Val Ile Asn Ala Ile Ile Asp Glu 
            660                 665                 670         


Tyr Gly Lys Pro Asp Glu Ile Arg Ile Glu Met Ala Arg Glu Leu Lys 
        675                 680                 685             


Ser Ser Ala Ala Asp Arg Lys Lys Thr Thr His Ala Ile Ser Gln Gly 
    690                 695                 700                 


Asn Ala Glu Asn Gln Arg Ile Arg Glu Ile Leu Glu Lys Glu Phe Ser 
705                 710                 715                 720 


Leu Ser Tyr Ile Ser Arg Asn Asp Ile Ile Lys Tyr Lys Leu Tyr Glu 
                725                 730                 735     


Glu Leu Glu Pro Asn Tyr Tyr Lys Thr Leu Tyr Ser Asp Thr Tyr Ile 
            740                 745                 750         


Thr Lys Asp Lys Leu Phe Ser Lys Asp Phe Asp Ile Glu His Ile Ile 
        755                 760                 765             


Pro Lys Ala Arg Leu Phe Asp Asp Ser Phe Ser Asn Lys Thr Leu Glu 
    770                 775                 780                 


Ala Arg Asn Ile Asn Leu Glu Lys Ser Asn Lys Thr Ala Phe Asp Phe 
785                 790                 795                 800 


Ile Lys Glu Lys Tyr Gly Glu Asp Gly Ala Glu Ala Tyr Lys Lys Lys 
                805                 810                 815     


Leu Asp Met Leu Leu Glu Asn Asp Ala Ile Ser Arg Pro Lys Tyr Asn 
            820                 825                 830         


Asn Leu Leu Arg Ala Glu Ala Asp Ile Pro Ser Asp Phe Ile Asn Arg 
        835                 840                 845             


Asp Leu Arg Asn Thr Gln Tyr Ile Ala Lys Lys Ala Cys Glu Ile Leu 
    850                 855                 860                 


Gly Glu Leu Val Lys Thr Val Thr Pro Thr Thr Gly Lys Ile Thr Asn 
865                 870                 875                 880 


Arg Leu Arg Glu Asp Trp Gln Leu Val Asp Val Met Lys Glu Leu Asn 
                885                 890                 895     


Phe Glu Lys Tyr Glu Lys Leu Gly Leu Thr Glu Ile Val Glu Asp Arg 
            900                 905                 910         


Asp Gly Arg Lys Ile Lys Arg Ile Lys Asp Trp Thr Lys Arg Asn Asp 
        915                 920                 925             


His Arg His His Ala Met Asp Ala Leu Ala Ile Ala Phe Thr Lys Pro 
    930                 935                 940                 


Ser Phe Ile Gln Tyr Leu Asn Asn Leu Asn Ala Arg Ser Asn Lys Gly 
945                 950                 955                 960 


Asp Ser Ile Tyr Ala Ile Glu Asn Lys Glu Leu His Tyr Glu Glu Gly 
                965                 970                 975     


Lys Leu Arg Phe Asn Ala Pro Ile Pro Val Asn Glu Phe Arg Ala Glu 
            980                 985                 990         


Ala Lys Arg His Leu Ser Ala Ile  Leu Val Ser Ile Lys  Ala Lys Asn 
        995                 1000                 1005             


Lys Val  Met Thr Gln Asn Val  Asn Lys Ile Lys Thr  Lys His Gly 
    1010                 1015                 1020             


Ile Ile  Lys Lys Ile Gln Leu  Thr Pro Arg Gly Pro  Leu His Asn 
    1025                 1030                 1035             


Glu Thr  Ile Tyr Gly Thr Lys  Met Arg Pro Ile Ile  Lys Met Val 
    1040                 1045                 1050             


Lys Val  Gly Ala Ala Leu Asp  Glu Ala Thr Ile Asn  Lys Val Ser 
    1055                 1060                 1065             


Ser Pro  Ala Ile Arg Glu Ala  Leu Leu Lys Arg Leu  Asn Glu Tyr 
    1070                 1075                 1080             


Ser Gly  Asn Ala Lys Lys Ala  Phe Thr Gly Lys Asn  Thr Leu Glu 
    1085                 1090                 1095             


Lys Asn  Pro Ile Tyr Leu Asn  Ala Gly Arg Thr Lys  Thr Val Pro 
    1100                 1105                 1110             


Ser Leu  Val Lys Thr Val Glu  Trp Glu Ser Phe His  Pro Thr Arg 
    1115                 1120                 1125             


Lys Leu  Ile Asp Lys Asp Leu  Asn Val Asp Lys Val  Val Asp Lys 
    1130                 1135                 1140             


Gly Ile  Arg Glu Ile Leu Lys  Ala Arg Leu Glu Glu  Phe Asn Gly 
    1145                 1150                 1155             


Asp Ala  Lys Lys Ala Phe Ser  Asn Leu Glu Glu Asn  Pro Ile Tyr 
    1160                 1165                 1170             


Leu Asp  Glu Ala Lys Lys Ile  Ala Leu Lys Arg Val  Ser Ile Glu 
    1175                 1180                 1185             


Gly Val  Leu Ser Ala Ile Pro  Leu His Thr Leu Lys  Asn Gln Ala 
    1190                 1195                 1200             


Gly Lys  Pro Ile Thr Gly Lys  Asp Gly Lys Pro Val  Leu Gly Asn 
    1205                 1210                 1215             


Tyr Val  Gln Thr Ser Asn Asn  His His Ile Ala Phe  Tyr Tyr Asp 
    1220                 1225                 1230             


Glu Asp  Gly Asn Leu Gln Asp  Asn Ala Val Ser Phe  Phe Glu Ala 
    1235                 1240                 1245             


Ala Glu  Arg Lys Ser Gln Gly  Ile Pro Val Ile Asp  Lys Asp Tyr 
    1250                 1255                 1260             


Asn Arg  Asp Lys Gly Trp Arg  Phe Leu Phe Thr Met  Lys Gln Asn 
    1265                 1270                 1275             


Glu Tyr  Phe Val Phe Pro Asn  Glu Ala Thr Gly Phe  Ile Pro Ser 
    1280                 1285                 1290             


Glu Val  Asp Leu Thr Asp Glu  Ala Asn Tyr Gly Ile  Ile Ser Pro 
    1295                 1300                 1305             


Asn Leu  Tyr Arg Val Gln Lys  Val Ser Arg Ile Asp  Lys Gly Thr 
    1310                 1315                 1320             


Ser Ala  Ser Arg Asp Tyr Trp  Phe Arg His His Leu  Glu Thr Ile 
    1325                 1330                 1335             


Leu Asn  Asp Asp Ala Lys Leu  Lys Asn Leu Ala Phe  Lys Arg Ile 
    1340                 1345                 1350             


Arg Gly  Leu Leu Glu Leu Lys  Asp Ile Ile Lys Val  Arg Ile Asn 
    1355                 1360                 1365             


Ser Thr  Gly Lys Ile Val Ala  Val Gly Glu Tyr Asp  
    1370                 1375                 1380 


<210> 393
<211> 1425
<212> PRT
<213> Prevotella micans


<220>
<223> Prevotella micans F0438

<400> 393
Met Ile Gln Lys Ile Phe Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly 
1               5                   10                  15      


Ser Ser Val Arg Asn Leu Glu Leu Gly Glu Asn Leu Thr Glu Gln Leu 
            20                  25                  30          


Glu Phe Phe Ser Ser Asp Ile Phe Gly Ser Ser Val Ser Lys Asn Ser 
        35                  40                  45              


Asn Gly Arg Glu Tyr Ser Leu Ala Gly Asn Arg Ser Ala His Arg Arg 
    50                  55                  60                  


Ser Arg Gly Leu Asn Glu Ala Arg Arg Arg Lys Leu Trp Ala Thr Leu 
65                  70                  75                  80  


Asp Leu Leu Ile Glu His Gly Leu Cys Pro Met Ser Pro Asp Ser Leu 
                85                  90                  95      


Met Gln Trp Arg Thr Tyr Asp Lys Gln Lys Gly Leu Tyr Arg Gln Tyr 
            100                 105                 110         


Pro Ile Glu Asp Lys Asp Phe Asn Ala Trp Ile Met Leu Asp Phe Asn 
        115                 120                 125             


Gly Asp Gly Lys Pro Asp Tyr Ser Ser Pro Tyr Gln Leu Arg Arg Glu 
    130                 135                 140                 


Leu Val Val Arg Gln Phe Asp Phe Asp Gln Pro Ile Glu Arg Tyr Lys 
145                 150                 155                 160 


Leu Gly Arg Ala Leu Tyr His Ile Ala Gln His Arg Gly Phe Lys Ser 
                165                 170                 175     


Ser Lys Gly Glu Thr Ile Ala Asp Gln Glu Lys Asn Glu Lys Lys Pro 
            180                 185                 190         


Ile Ala Glu Glu Gly Ala Asp Ile Ala Asn Glu Met Lys Ala Ser Glu 
        195                 200                 205             


Thr Lys Leu Ser Lys Gly Leu Val Ala Tyr Met Gln Glu Asn His Leu 
    210                 215                 220                 


Lys Thr Val Gly Glu Ala Phe Ala Lys Leu Glu Asp Glu Arg Val Arg 
225                 230                 235                 240 


Ile Arg Asn Asn Glu Ser Tyr Arg Ala Ile Arg Ser Gln Tyr Gln Asp 
                245                 250                 255     


Glu Ile Lys Glu Ile Phe Thr Tyr Gln Lys Lys Leu Ser Val Glu Ser 
            260                 265                 270         


Glu Leu Tyr Glu Arg Leu Thr Ser Glu Lys Lys Gly Val Gly Thr Ile 
        275                 280                 285             


Phe Tyr Lys Arg Pro Leu Arg Ser Gln Arg Gly Asn Val Gly Lys Cys 
    290                 295                 300                 


Thr Leu Glu Arg Asn Lys Pro Arg Cys Pro Ile Gly Arg Pro Glu Phe 
305                 310                 315                 320 


Glu Glu Phe Arg Ala Trp Thr Leu Ile Asn Asn Ile Lys Ile Arg Glu 
                325                 330                 335     


Thr Ala Gly Glu Pro Tyr Lys Gln Leu Pro Ile Lys Leu Arg Gln Glu 
            340                 345                 350         


Leu Leu Lys Asp Cys Phe Leu Ser Lys Val Lys Ala Asp Phe Lys Phe 
        355                 360                 365             


Glu Asp Ile Arg Lys Tyr Ile Glu Lys Arg Leu Gly Leu Ser Phe Ser 
    370                 375                 380                 


Asn Asp Asp Lys Thr Ile Asn Tyr Lys Asp Ser Val Ser Ile Ala Ala 
385                 390                 395                 400 


Cys Pro Val Thr Val Arg Met Lys Lys Leu Leu Gly Glu Asn Trp Ala 
                405                 410                 415     


Asn Cys Arg Ile Asp Gly Glu Lys Arg Arg Gln Ala His Gly Lys Asn 
            420                 425                 430         


Asn Asn Asn Glu His Ile Val Ser Tyr Thr Glu Glu Asp Ile Trp His 
        435                 440                 445             


Val Cys Tyr Asn Ala Glu Asp Pro Glu Glu Val Ser Asn Phe Ala Arg 
    450                 455                 460                 


Lys Ala Leu His Trp Asp Glu Asn Lys Ile Lys Glu Leu Val Arg Leu 
465                 470                 475                 480 


Trp Thr Ser Ile Pro Gln Gly Tyr Ala Met Leu Ser Leu Lys Ala Ile 
                485                 490                 495     


Arg Asn Ile Asn Arg Met Leu Leu Leu Gly Leu Lys Tyr Ser Asp Ala 
            500                 505                 510         


Val Leu Leu Ala Lys Leu Pro Asp Ile Val Pro Val Ser Asp Glu Asp 
        515                 520                 525             


Ile Leu Ala Ile Thr Lys Glu Phe Leu Gln Leu Glu Asp Lys Leu Asn 
    530                 535                 540                 


Gln Glu Lys Gln Ile Asn Asn Ile Val Asn Ser Leu Ile Ala Asn Tyr 
545                 550                 555                 560 


Lys Ser Lys Leu Glu Glu Asn Arg Phe Ala Asp His Asn Tyr Gln Tyr 
                565                 570                 575     


Gln Leu Gly Glu Gly Asp Asp Glu Asp Ile Asn Thr Gln Ile Lys Ser 
            580                 585                 590         


His Ile Gly Ala Lys Leu Trp Val Gln Ile Gly Ala Asp Glu Gln Thr 
        595                 600                 605             


Lys Ile Phe Gln Ala Val Arg Ser Lys Tyr Gln Asp Phe Phe Lys Ser 
    610                 615                 620                 


Tyr Lys Arg Lys Phe Val Glu Ser Pro Lys Leu Gly Glu Leu Leu Val 
625                 630                 635                 640 


Ala Phe Leu Thr Glu Lys Phe Pro Asn Val Lys Ser Lys Gln Trp Glu 
                645                 650                 655     


Arg Leu Tyr His Pro Ser Gln Ile Ala Ile Tyr Arg Pro Ile Pro Val 
            660                 665                 670         


Asp Asn Asp Arg Ser Lys Leu Arg Leu Gly Asn Pro Asn Ile Gly Ala 
        675                 680                 685             


Ile Lys Asn Pro Thr Val Met Arg Val Leu Asn Thr Leu Arg Arg Arg 
    690                 695                 700                 


Val Asn Gln Leu Leu Asp Asp Gly Val Ile Ser Pro Asp Glu Thr Arg 
705                 710                 715                 720 


Val Val Val Glu Thr Ala Arg Glu Leu Asn Asp Ala Asn Thr Lys Trp 
                725                 730                 735     


Ala Leu Asp Arg Tyr Asn Arg Ile Arg Arg Asp Glu Asn Glu Lys Ile 
            740                 745                 750         


Arg Lys Ile Leu Lys Glu Leu Asn Pro Thr Thr Asn Ser Ile Ser Glu 
        755                 760                 765             


Gln Asp Ile Asp Lys Ala Arg Tyr Ile Phe Glu Gln Cys Glu Thr Asp 
    770                 775                 780                 


Phe Tyr Thr Asp Gly Lys Val Pro Tyr Tyr Asn Lys Asp Ile Lys Lys 
785                 790                 795                 800 


Tyr Lys Leu Trp Leu Glu Gln Gly Gly Gln Cys Leu Tyr Thr Gly Gln 
                805                 810                 815     


Thr Ile Asn Leu Thr Asn Leu Phe Asn Pro Asn Ala Phe Asp Met Glu 
            820                 825                 830         


His Thr Ile Pro Lys Ser Ile Ser Phe Asp Asn Ser Asp Gln Asn Leu 
        835                 840                 845             


Thr Leu Cys Glu Ser Tyr Tyr Asn Arg Phe Ile Lys Lys Asn Asn Ile 
    850                 855                 860                 


Pro Thr Asp Met Pro Asn Tyr Asp Lys Asp Val Thr Ile Asn Gly Lys 
865                 870                 875                 880 


Glu Tyr Thr Ala Ile Lys Pro Arg Leu Gln Arg Trp Lys Glu Arg Val 
                885                 890                 895     


Asp Arg Leu Ser Arg Asn Val Asp Phe Trp Lys Gly Gln Ala Arg Arg 
            900                 905                 910         


Ala Gln Asp Lys Asp Arg Lys Asp Glu Cys Ile Arg Glu Lys His Leu 
        915                 920                 925             


Trp Asp Met Glu Leu Ala Tyr Trp Lys Gly Lys Leu Glu Arg Phe Thr 
    930                 935                 940                 


Met Thr Asp Val Thr Asp Gly Phe Lys Asn Ser Gln Leu Val Asp Thr 
945                 950                 955                 960 


Arg Val Ile Thr Arg His Ala Val Leu Tyr Leu Lys Ser Ile Phe Asn 
                965                 970                 975     


His Val Glu Val Gln Arg Gly Glu Thr Thr Ala Glu Phe Arg Lys Ile 
            980                 985                 990         


Leu Gly Leu Gln Ser Ile Asp Glu  Lys Lys Asp Arg Ser  Leu His Ser 
        995                 1000                 1005             


His His  Ala Ile Asp Ala Thr  Met Leu Thr Val Ile  Pro Ser Ala 
    1010                 1015                 1020             


Ala Lys  Arg Asp Arg Met Leu  Glu Leu Phe Tyr Lys  Ile Glu Glu 
    1025                 1030                 1035             


Thr Lys  Lys Ala Leu Lys Asn  Tyr Asn Asp Asn Asn  Lys Thr Gly 
    1040                 1045                 1050             


Leu Asn  Leu Glu Leu Lys Gly  Leu Glu Glu Lys Leu  Asp Lys Glu 
    1055                 1060                 1065             


Lys Lys  Asp Cys Arg Val Gly  Arg Arg Val Asn Asp  Leu Asp Arg 
    1070                 1075                 1080             


Phe Ile  Asn Glu Asn Ile Ile  Val Ser His His Thr  Lys Asp Gln 
    1085                 1090                 1095             


Ala Leu  Thr Pro Ala His Arg  Arg Leu Arg Lys Arg  Gly Lys Ile 
    1100                 1105                 1110             


Val Gly  Gly Lys Glu His Pro  Arg Trp Gln Thr Gly  Asp Ser Leu 
    1115                 1120                 1125             


Arg Gly  Glu Ile His Lys Ala  Ser Tyr Tyr Gly Ala  Ile Thr Gln 
    1130                 1135                 1140             


Phe Ala  Lys Asp Ala Asn Gly  Lys Val Leu Met Lys  Asp Gly Gln 
    1145                 1150                 1155             


Ala Gln  Ile Asp Pro Thr Ile  Tyr Tyr Val Ile Arg  Arg Glu Leu 
    1160                 1165                 1170             


Lys Tyr  Lys Arg Ser Thr Gln  Asp Ser Gly Phe Thr  Asn Trp Glu 
    1175                 1180                 1185             


Asp Leu  Glu Lys Val Ile Val  Asp Thr Asp Leu Phe  Gly Leu Met 
    1190                 1195                 1200             


Lys Gly  Gln Phe Pro Glu Gly  Thr Ser Phe Lys Asp  Ala Cys Glu 
    1205                 1210                 1215             


Gln Gly  Phe Tyr Met Ile Lys  Lys Gly Lys Asn Gly  Glu Gly Asp 
    1220                 1225                 1230             


Val Lys  Thr His Arg Ile Arg  His Val Arg Cys Lys  Ala Val Lys 
    1235                 1240                 1245             


Thr Ala  Leu Arg Ile Lys Glu  Gln Thr Tyr Lys Ser  Ser Lys Asp 
    1250                 1255                 1260             


Tyr Lys  Gln Phe Phe Tyr Ala  Ala Val Gly Asp Leu  Tyr Val Met 
    1265                 1270                 1275             


Cys Tyr  Tyr Thr Asp Gly Lys  Lys Arg Asp Phe Lys  Ile Tyr Ser 
    1280                 1285                 1290             


Leu Tyr  Asp Ile Ser Asn His  Arg Lys Ser Gly Thr  Glu Asp Ile 
    1295                 1300                 1305             


Pro Lys  Phe Ile Thr Asp Lys  Lys Gly Asn His Leu  Pro Leu Asp 
    1310                 1315                 1320             


Tyr Lys  Leu Arg Thr Gly Asp  Met Val Leu Leu Tyr  Lys Asp Asn 
    1325                 1330                 1335             


Pro Glu  Glu Leu Lys Asp Leu  Asp Gln Val Asn Leu  Lys Arg Arg 
    1340                 1345                 1350             


Leu Tyr  Lys Val Asn Arg Phe  Glu Ser Glu Gly Leu  Ile Ile Leu 
    1355                 1360                 1365             


Leu Thr  His His Leu Ser Thr  Thr Thr Glu Arg Gly  Cys Ser Ile 
    1370                 1375                 1380             


Gly Lys  Ile Glu Asn Tyr Gln  Asn Leu Pro Thr Ala  Ile Arg Cys 
    1385                 1390                 1395             


Gly Ile  Lys Thr Ile Lys Phe  Leu Ile Met Gly Lys  His Arg Asp 
    1400                 1405                 1410             


Phe Val  Ile Arg Asn Gly Asn  Ile Glu Phe Lys His  
    1415                 1420                 1425 


<210> 394
<211> 1506
<212> PRT
<213> Prevotella nigrescens


<220>
<223> Prevotella nigrescens ATCC 33563

<400> 394
Met Lys Thr Ile Leu Gly Leu Asp Leu Gly Pro Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Lys Val Glu Val Asp Asp Glu Gly Asn Tyr Leu Arg Asn Ile Lys 
            20                  25                  30          


Leu Gly Ser Arg Ile Ile Pro Met Thr Gln Asp Met Leu Gly Asp Phe 
        35                  40                  45              


Asp Lys Gly Val Lys Val Ser Gln Thr Ala Ile Arg Thr Asp Phe Arg 
    50                  55                  60                  


Gly Asn Arg Arg Leu Ile Glu Arg His Leu Leu Arg Arg Glu Arg Leu 
65                  70                  75                  80  


His Arg Val Leu His Ala Leu Lys Phe Leu Pro Lys His Tyr Glu Asp 
                85                  90                  95      


Ala Ile Gly Trp Asp Arg Asn Glu Pro Ala Thr Tyr Gly Lys Phe Val 
            100                 105                 110         


Asn Asn Ser Glu Pro Lys Leu Ala Trp Glu Arg Gln Glu Asp Gly Ser 
        115                 120                 125             


Met Arg Phe Leu Phe Met Glu Ser Phe Asn Glu Met Val Ala Asp Phe 
    130                 135                 140                 


Ala Gln Asn Gln Pro Ser Leu Val Ser Asp Gly Lys Lys Ile Pro Leu 
145                 150                 155                 160 


Asp Trp Thr Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Thr Arg Pro Ile 
                165                 170                 175     


Lys Lys Glu Glu Leu Ala Trp Ile Leu Leu Asn Phe Asn Gln Lys Arg 
            180                 185                 190         


Gly Tyr Tyr Gln Leu Arg Gly Glu Glu Glu Glu Asp Asn Leu Thr Lys 
        195                 200                 205             


Arg Lys Glu Tyr Tyr Lys Leu Lys Val Val Gly Val Glu Ala Asp Gly 
    210                 215                 220                 


Ala Pro Lys Gly Gly Lys Thr Trp Tyr Asn Ile His Leu Glu Asn Gly 
225                 230                 235                 240 


Trp Thr Ala Arg Cys Gln Ser Lys Ile Pro Leu Asp Asp Trp Val Gly 
                245                 250                 255     


Lys Val Lys Glu Tyr Ile Val Thr Thr Glu Tyr Glu Asp Asp Gly Lys 
            260                 265                 270         


Thr Pro Lys Cys Asp Lys Glu Gly Lys Val Lys Arg Ser Phe Lys Ser 
        275                 280                 285             


Pro Glu Lys Asp Asp Trp Gln Leu Ile Lys Thr Arg Thr Glu Lys Phe 
    290                 295                 300                 


Ile Asp Asp Ser Asn Lys Thr Val Gly Ala Phe Ile Tyr Asp Tyr Leu 
305                 310                 315                 320 


Leu Glu Lys Pro Phe Asp Lys Ile Arg Gly Lys Tyr Ile Arg Thr Ile 
                325                 330                 335     


Glu Arg Lys Tyr Tyr Lys Asn Glu Leu Arg Glu Ile Leu Arg Glu Gln 
            340                 345                 350         


Thr Lys Tyr His Glu Gly Leu His Ser Leu Glu Ala Leu Lys Ile Cys 
        355                 360                 365             


Ala Glu Glu Leu Tyr Lys Asn Asn Gln Gln His Gln Glu Tyr Leu Leu 
    370                 375                 380                 


Lys Lys Asp Met Thr Phe Leu Leu Leu Asn Asp Leu Ile Phe Tyr Gln 
385                 390                 395                 400 


Arg Pro Leu Lys Ser Lys Lys Ser Leu Ile Ala Asp Cys Pro Tyr Glu 
                405                 410                 415     


Val Tyr Lys Tyr Asp Asp Lys Leu Thr Gly Lys Lys Gly Gln Lys Lys 
            420                 425                 430         


Ile Lys Cys Ile Ala Lys Ser Asn Pro Tyr Tyr Gln Glu Phe Arg Leu 
        435                 440                 445             


Trp Gln Phe Ile Ala Asn Leu Arg Leu Phe Ser Val Thr Asp Gly Lys 
    450                 455                 460                 


Glu Val Thr Ala Glu Tyr Leu Lys Thr Glu Glu Asp Tyr Val Arg Leu 
465                 470                 475                 480 


Phe Ser Phe Leu Asn Asp Arg Lys Asp Ile Lys Gln Glu Thr Phe Leu 
                485                 490                 495     


Arg Ser Phe Leu Lys Leu Lys Lys Glu Ser Ile Gly Ser Glu Lys Ile 
            500                 505                 510         


Tyr Pro Ile Arg Trp Asn Tyr Ile Glu Asp Ala Asn Lys Ser Tyr Pro 
        515                 520                 525             


Cys Asn Ala Thr Arg His Glu Leu Leu Leu Ala Phe Asp Arg Ala Asp 
    530                 535                 540                 


Ile Pro Arg Glu Leu Leu Asp Val Glu Glu Arg Glu Tyr Arg Leu Trp 
545                 550                 555                 560 


His Leu Leu Tyr Ser Ile Glu Ala Lys Glu Glu Thr Glu Ser Ala Leu 
                565                 570                 575     


Arg Lys Leu Lys Ala Asn Lys Ala Phe Gly Asp Leu Asn Ile Asp Asp 
            580                 585                 590         


Ala Phe Val Asn Ser Phe Leu Lys Ile Lys Pro Phe Glu Lys Glu Tyr 
        595                 600                 605             


Gly Ala Tyr Ser Glu Lys Ala Ile Lys Lys Leu Leu Ala Val Met Arg 
    610                 615                 620                 


Arg Gly Ser Leu Trp Lys Glu Ala Asp Ile Cys Glu Ala Thr Lys Gln 
625                 630                 635                 640 


Asn Ile Ala Lys Ile Leu Gln Asn Asp Ile Asp Glu Lys Leu Lys Lys 
                645                 650                 655     


Lys Ile Glu Ala Ala Val Ser Ser Phe Asn Lys Leu Ser Asp Phe Gln 
            660                 665                 670         


Gly Leu Pro Thr Trp Leu Ala Cys Tyr Val Val Tyr Gly Arg His Ser 
        675                 680                 685             


Glu Ala Ala Gln Ile Gln Cys Trp Gln Ser Pro Glu Asp Leu Lys Thr 
    690                 695                 700                 


Tyr Ile Asn Lys Phe Lys Gln His Ser Leu Arg Asn Pro Ile Val Glu 
705                 710                 715                 720 


Gln Cys Leu Leu Glu Thr Leu Arg Thr Val Tyr Asp Ile Trp Lys Asp 
                725                 730                 735     


Ala Gly Gln Ile Asp Glu Ile His Ile Glu Leu Gly Arg Asn Met Lys 
            740                 745                 750         


Ser Thr Ala Glu Gln Arg Ala Arg Lys Thr Lys Asp Ile Leu Arg Asn 
        755                 760                 765             


Glu Asn Thr Asn Leu Arg Ile Lys Asn Leu Leu Val Glu Leu Lys Asn 
    770                 775                 780                 


Asp Asp Lys Ile Glu Asn Val Arg Pro Tyr Ser Pro Ser Gln Gln Glu 
785                 790                 795                 800 


Ile Leu Arg Ile Tyr Glu Glu Gly Ala Leu Gln Glu Leu Ser Lys Glu 
                805                 810                 815     


Asp Glu Met Phe Glu Asp Ile Ser Lys Ile Ser Lys Met Ala Gln Pro 
            820                 825                 830         


Ser Pro Thr Glu Leu Ser Arg Tyr Lys Leu Trp Leu Glu Gln Lys Tyr 
        835                 840                 845             


Arg Ser Pro Tyr Thr Gly Arg Val Ile Pro Leu Ser Lys Leu Phe Thr 
    850                 855                 860                 


Thr Ala Tyr Gln Ile Glu His Ile Ile Pro Gln Ser Arg Tyr Phe Asp 
865                 870                 875                 880 


Asp Ser Phe Asn Asn Lys Val Ile Cys Glu Ser Glu Val Asn Ser Leu 
                885                 890                 895     


Lys Asp Asn Met Leu Gly Tyr Glu Phe Ile Lys Glu Cys Gly Gly Arg 
            900                 905                 910         


Ile Val His Cys Thr Leu Leu Gly Asp Val Lys Ile Phe Thr Lys Glu 
        915                 920                 925             


Glu Tyr Lys Asp Phe Val Thr Lys His Tyr Ile Asp Asn Thr Tyr Lys 
    930                 935                 940                 


Arg Asp Lys Leu Leu Leu Glu Asp Ile Pro Gln Glu Phe Ser Ala Arg 
945                 950                 955                 960 


Gln Leu Asn Asp Ser Arg Tyr Ile Ser Lys Met Val Gln Thr Val Leu 
                965                 970                 975     


Ser Asn Ile Val Arg Ala Glu Asn Glu Gln Glu Ala Thr Ser Lys Phe 
            980                 985                 990         


Val Val Ser Cys Asn Gly Ala Ile  Thr Asn Arg Leu Lys  Lys Asp Trp 
        995                 1000                 1005             


Gly Leu  Asn Asp Val Trp Ser  Ser Ile Val Cys Pro  Arg Phe Lys 
    1010                 1015                 1020             


Arg Leu  Asn Glu Ile Thr Lys  Thr Asn Ala Phe Gly  His Trp Glu 
    1025                 1030                 1035             


Asp Lys  Ala Gly Lys His Val  Phe Gln Thr Thr Val  Pro Leu Glu 
    1040                 1045                 1050             


Leu Gln  Arg Gly Phe Ser Lys  Lys Arg Ile Asp His  Arg His His 
    1055                 1060                 1065             


Ala Met  Asp Ala Leu Val Ile  Ala Cys Ala Ser Arg  Asn Ile Val 
    1070                 1075                 1080             


Asn Tyr  Leu Asn Asn Glu Ser  Ala Asn Ser Pro Glu  Lys Arg Glu 
    1085                 1090                 1095             


Asp Leu  Arg Lys Lys Leu Cys  Asp Glu Lys Arg Lys  Ile Arg Lys 
    1100                 1105                 1110             


Pro Trp  Lys Thr Phe Thr Gln  Asp Ala Arg Glu Ala  Leu Ser Asp 
    1115                 1120                 1125             


Val Val  Val Ser Phe Lys Asn  Tyr Val Arg Val Ile  Asn Lys Ala 
    1130                 1135                 1140             


Thr Asn  Tyr Tyr Glu His Tyr  Ser Ser Ser Gly Asn  Lys Val Met 
    1145                 1150                 1155             


Ile Ser  Gln Lys Gly Asn Asp  Met Trp Ala Ile Arg  Lys Pro Leu 
    1160                 1165                 1170             


His Lys  Glu Ser Val Phe Gly  Arg Val Asn Leu Cys  Arg Lys Val 
    1175                 1180                 1185             


Ile Val  Ser Leu Lys Lys Ala  Leu Glu Asn Ile Pro  Ala Ile Cys 
    1190                 1195                 1200             


Asp Lys  Thr Leu Arg Asp Tyr  Ile Asn Ala Leu Val  Glu Lys His 
    1205                 1210                 1215             


Phe Asn  Thr Arg Gln Leu Leu  Ala His Phe Lys Ser  Ile Asn Tyr 
    1220                 1225                 1230             


Arg Leu  Asn Arg Gln Cys Val  Glu Lys Val Glu Val  Trp Gln Phe 
    1235                 1240                 1245             


Ser Asp  Glu Lys Ile Glu Met  Val Ala Arg Arg Lys  Ser Leu Asp 
    1250                 1255                 1260             


Thr Ser  Phe Asp Asp Lys Gln  Ile Ser Ser Ile Thr  Asp Thr Gly 
    1265                 1270                 1275             


Ile Gln  Lys Ile Leu Leu Asn  Tyr Leu Gln Thr Lys  Asp Gly Asn 
    1280                 1285                 1290             


Ala Glu  Ile Ala Phe Thr Pro  Glu Gly Ile Glu Glu  Met Asn Lys 
    1295                 1300                 1305             


Asn Ile  Ser Leu Tyr Asn Asp  Gly Lys Ala His Gln  Pro Ile Leu 
    1310                 1315                 1320             


Lys Val  Arg Val Ala Thr Pro  Lys Gly Met Lys Tyr  Pro Val Gly 
    1325                 1330                 1335             


Gln Thr  Gly Asn Lys Ala Thr  Lys Phe Val Val Ala  Glu Lys Gly 
    1340                 1345                 1350             


Thr Asn  Leu Tyr Phe Ala Ile  Tyr Glu Asn Glu Leu  Gly Val Arg 
    1355                 1360                 1365             


Ser Tyr  Asp Thr Ile Pro Leu  Asn Ile Val Val Glu  Arg Leu Lys 
    1370                 1375                 1380             


Glu Gly  Leu Ser Pro Val Pro  Gln Ala Asn Glu Ala  Asp Ile Pro 
    1385                 1390                 1395             


Leu Lys  Phe Tyr Leu Ser Pro  Asn Asp Leu Val Tyr  Val Pro Thr 
    1400                 1405                 1410             


Lys Glu  Asn Glu Asp Glu Leu  Cys Arg Asp Arg Ile  Tyr Lys Phe 
    1415                 1420                 1425             


Val Asp  Ser Ser Gly Thr Thr  Ala Asn Phe Val Pro  His Thr Ser 
    1430                 1435                 1440             


Ala Asn  Thr Ile Tyr Asn Val  Asp Lys Glu Tyr Ala  Glu Lys Cys 
    1445                 1450                 1455             


Cys Asn  Gly Ala Val Phe Leu  Asn Glu Tyr Gly Leu  Gly Ser Pro 
    1460                 1465                 1470             


Gln Ser  Lys Asn Gln Arg Ala  Leu Thr Gly Glu Met  Ile Lys Glu 
    1475                 1480                 1485             


Ile Cys  Trp Lys Leu Lys Val  Asp Arg Leu Gly Asn  Ile Ile Lys 
    1490                 1495                 1500             


Val Ile  Lys 
    1505     


<210> 395
<211> 1380
<212> PRT
<213> Prevotella nigrescens


<220>
<223> Prevotella nigrescens F0103

<400> 395
Met Lys Arg Ile Leu Gly Leu Asp Leu Gly Thr Thr Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Asn Glu Ala Glu Ser Asn Asn Glu Ala Ser Ser Ile Val 
            20                  25                  30          


Arg Leu Gly Val Arg Val Asn Pro Leu Thr Val Asp Glu Lys Ser Asn 
        35                  40                  45              


Phe Glu Lys Gly Lys Ala Ile Thr Thr Asn Ala Asp Arg Gln Leu Arg 
    50                  55                  60                  


His Gly Ala Arg Ile Asn Leu Gln Arg Tyr Lys Leu Arg Arg Gln Asn 
65                  70                  75                  80  


Leu His Asp Cys Leu Gln Lys Gln Gly Trp Leu Gly Thr Glu Ala Met 
                85                  90                  95      


Tyr Glu Glu Gly Lys Ala Ser Thr Phe Glu Thr Tyr Lys Leu Arg Ala 
            100                 105                 110         


Lys Ala Ala Glu Glu Glu Ile Ser Leu His Glu Phe Ala Arg Val Leu 
        115                 120                 125             


Phe Met Leu Asn Lys Lys Arg Gly Tyr Lys Ser Asn Arg Lys Ala Asn 
    130                 135                 140                 


Asn Lys Glu Asp Gly Gln Leu Phe Asp Gly Met Thr Ile Ala Lys Lys 
145                 150                 155                 160 


Leu Tyr Glu Glu His Leu Thr Pro Ala Glu Tyr Ser Leu Gln Leu Leu 
                165                 170                 175     


Asn Lys Gly Lys Lys Phe Thr Gln Gly Tyr Tyr Arg Ser Asp Leu Asn 
            180                 185                 190         


Ala Glu Leu Glu Arg Ile Trp Asp Glu Gln Lys Lys Tyr Tyr Pro Glu 
        195                 200                 205             


Ile Leu Thr Asp Glu Phe Lys Gln Gln Leu Glu Gly Lys Thr Lys Thr 
    210                 215                 220                 


Asn Thr Ser Lys Ile Phe Leu Ala Lys Tyr Gly Ile Tyr Ser Ala Asp 
225                 230                 235                 240 


Leu Lys Gly Leu Asp Arg Lys Leu Gln Pro Leu Lys Trp Arg Val Glu 
                245                 250                 255     


Ala Leu Lys Gln Gln Val Asp Lys Glu Val Leu Ala Phe Val Ile Ser 
            260                 265                 270         


Asp Leu Lys Gly Gln Ile Ala Asn Thr Ser Gly Leu Leu Gly Ala Ile 
        275                 280                 285             


Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Lys Gln Thr Val Gly Gln 
    290                 295                 300                 


Tyr Leu Trp Ala Ser Leu Glu Glu Asn Pro His Ile Ser Ile Lys Asn 
305                 310                 315                 320 


Lys Pro Phe Tyr Arg Gln Asp Tyr Leu Asp Glu Phe Glu Lys Ile Trp 
                325                 330                 335     


Glu Thr Gln Ala Thr Phe His Lys Gln Leu Thr Pro Glu Leu Lys Gln 
            340                 345                 350         


Glu Ile Arg Asp Ile Ile Ile Phe Tyr Gln Arg Pro Leu Lys Ser Lys 
        355                 360                 365             


Lys Ser Leu Ile Ser Val Cys Glu Leu Glu Gln Arg Lys Val Lys Ala 
    370                 375                 380                 


Thr Ile Asp Gly Lys Glu Lys Glu Ile Thr Ile Gly Pro Lys Val Ala 
385                 390                 395                 400 


Pro Lys Ser Ser Pro Val Phe Gln Glu Phe Arg Ile Trp Gln Asn Leu 
                405                 410                 415     


Asn Asn Val Leu Leu Ile Asp Asn Asp Thr Asn Glu Lys Arg Pro Leu 
            420                 425                 430         


Asp Glu Asp Glu Arg Tyr Leu Leu Tyr Lys Glu Leu Ser Ile Lys Ala 
        435                 440                 445             


Lys Leu Ser Lys Thr Glu Ala Leu Lys Ile Leu Asn Lys Lys Gly Lys 
    450                 455                 460                 


Gln Trp Asp Leu Asn Tyr Lys Glu Leu Glu Gly Asn Arg Thr Gln Ala 
465                 470                 475                 480 


Ile Leu Phe Asp Cys Tyr Asn Arg Ile Ile Thr Leu Thr Gly His Glu 
                485                 490                 495     


Glu Cys Asp Phe Lys Lys Ile Lys Ala Ser Glu Ile Arg His Tyr Val 
            500                 505                 510         


Ser Thr Ile Phe Lys Asn Leu Gly Phe Ser Thr Glu Ile Leu Asp Phe 
        515                 520                 525             


Asp Pro Ser Leu Glu Lys His Glu Leu Glu Lys Gln Pro Met Tyr Gln 
    530                 535                 540                 


Leu Trp His Leu Leu Tyr Ser Tyr Glu Ser Asp Asn Ser Arg Thr Gly 
545                 550                 555                 560 


Asn Glu Ser Leu Leu Arg Lys Leu Glu Thr Thr Phe Gly Phe Pro Glu 
                565                 570                 575     


Glu Tyr Ala Thr Val Leu Cys Asp Val Val Phe Glu Glu Asp Tyr Gly 
            580                 585                 590         


Asn Leu Ser Val Lys Ala Met Arg Lys Ile Leu Pro Tyr Leu Gln Ala 
        595                 600                 605             


Gly Asn Asp Tyr Ser Gln Ala Cys Ala Tyr Ala Gly Tyr Asn His Ser 
    610                 615                 620                 


Arg His Ser Leu Thr Lys Glu Glu Leu Asp Gln Lys Val Tyr Lys Glu 
625                 630                 635                 640 


Arg Leu Glu Leu Leu Pro Lys Asn Ser Leu Arg Asn Pro Val Val Glu 
                645                 650                 655     


Lys Ile Leu Asn Gln Met Ile Asn Val Ile Asn Ala Ile Ile Asp Glu 
            660                 665                 670         


Tyr Gly Lys Pro Asp Glu Ile Arg Ile Glu Met Ala Arg Glu Leu Lys 
        675                 680                 685             


Ser Ser Ala Ala Asp Arg Lys Lys Thr Thr His Ala Ile Asn Gln Gly 
    690                 695                 700                 


Asn Asp Glu Asn Gln Cys Ile Arg Glu Ile Leu Glu Lys Glu Phe Ala 
705                 710                 715                 720 


Leu Ser Tyr Ile Ser Arg Asn Asp Ile Ile Lys Tyr Lys Leu Tyr Glu 
                725                 730                 735     


Glu Leu Lys Pro Asn Gly Phe Lys Thr Leu Tyr Ser Asp Thr Tyr Ile 
            740                 745                 750         


Pro Lys Asp Lys Leu Phe Ser Lys Asp Phe Asp Ile Glu His Ile Ile 
        755                 760                 765             


Pro Lys Ala Arg Leu Phe Asp Asp Ser Tyr Ser Asn Lys Thr Leu Glu 
    770                 775                 780                 


Ala Arg Asp Ile Asn Leu Ala Lys Ser Asn Lys Thr Ala Phe Asp Phe 
785                 790                 795                 800 


Val Lys Glu Lys Tyr Gly Glu Gln Gly Ala Glu Ala Tyr Lys Lys Lys 
                805                 810                 815     


Leu Asp Met Leu Leu Gly Asn Asn Val Ile Ser Lys Pro Lys Tyr Asn 
            820                 825                 830         


Lys Leu Leu Met Thr Glu Ala Asp Ile Pro Ser Asp Phe Ile Asn Arg 
        835                 840                 845             


Asp Leu Arg Asn Thr Gln Tyr Ile Ala Arg Lys Ala Cys Glu Ile Leu 
    850                 855                 860                 


Gly Glu Leu Val Arg Thr Val Thr Pro Thr Thr Gly Lys Ile Thr Asn 
865                 870                 875                 880 


Arg Leu Arg Glu Asp Trp Gln Leu Val Asp Val Met Lys Glu Leu Asn 
                885                 890                 895     


Phe Glu Lys Tyr Glu Lys Leu Gly Leu Thr Glu Ile Val Glu Asp Arg 
            900                 905                 910         


Asp Gly Arg Lys Ile Lys Arg Ile Lys Asp Trp Thr Lys Arg Asn Asp 
        915                 920                 925             


His Arg His His Ala Met Asp Ala Leu Ala Ile Ala Phe Thr Lys Pro 
    930                 935                 940                 


Ser Tyr Ile Gln Tyr Leu Asn Asn Leu Asn Ala Arg Ser Asn Lys Gly 
945                 950                 955                 960 


Asp Ser Ile Tyr Ala Ile Glu Asn Lys Glu Leu His Tyr Glu Glu Gly 
                965                 970                 975     


Lys Leu Arg Phe Asn Ala Pro Ile Pro Val Asn Val Phe Arg Ala Glu 
            980                 985                 990         


Ala Lys Arg His Leu Ser Ala Ile  Leu Val Ser Ile Lys  Ala Lys Asn 
        995                 1000                 1005             


Lys Val  Met Thr Gln Asn Val  Asn Lys Ile Lys Thr  Lys His Gly 
    1010                 1015                 1020             


Ile Ile  Lys Lys Ile Gln Leu  Thr Pro Arg Gly Pro  Leu His Asn 
    1025                 1030                 1035             


Glu Thr  Ile Tyr Gly Thr Lys  Met Arg Pro Ile Ile  Lys Lys Val 
    1040                 1045                 1050             


Lys Val  Gly Ala Ala Leu Asp  Glu Ala Thr Ile Asn  Lys Val Ser 
    1055                 1060                 1065             


Ser Pro  Ala Ile Arg Glu Val  Leu Leu Lys Arg Leu  Asn Glu Tyr 
    1070                 1075                 1080             


Ser Gly  Asn Ala Lys Lys Ala  Phe Thr Gly Lys Asn  Thr Leu Asp 
    1085                 1090                 1095             


Lys Asn  Pro Ile Tyr Leu Asn  Ala Glu Arg Thr Lys  Thr Val Pro 
    1100                 1105                 1110             


Ala Ser  Val Lys Thr Val Glu  Trp Glu Asn Tyr His  Pro Ile Arg 
    1115                 1120                 1125             


Lys Pro  Ile Thr Pro Asp Leu  Lys Val Asp Lys Val  Ile Asp Lys 
    1130                 1135                 1140             


Gly Ile  Gly Glu Ile Leu Lys  Ala Arg Leu Glu Glu  Phe Asn Gly 
    1145                 1150                 1155             


Asp Ala  Lys Lys Ala Phe Ser  Asn Leu Glu Glu Asn  Pro Ile Tyr 
    1160                 1165                 1170             


Leu Asp  Gln Thr Lys Lys Ile  Ala Leu Lys Arg Val  Ser Ile Glu 
    1175                 1180                 1185             


Gly Val  Leu Ser Thr Ile Pro  Leu His Thr Leu Lys  Asn Gln Ala 
    1190                 1195                 1200             


Gly Lys  Pro Ile Met Gly Lys  Asp Gly Lys Pro Val  Leu Gly Asn 
    1205                 1210                 1215             


Tyr Val  Gln Thr Ser Asn Asn  His His Ile Ala Phe  Tyr Tyr Asp 
    1220                 1225                 1230             


Glu Asp  Gly Asn Leu Gln Asp  Asn Ala Val Ser Phe  Phe Glu Ala 
    1235                 1240                 1245             


Ala Glu  Arg Lys Ser Gln Gly  Ile Ser Val Ile Asp  Lys Asp Tyr 
    1250                 1255                 1260             


Asn Arg  Asp Lys Gly Trp Arg  Phe Leu Phe Thr Met  Lys Gln Asn 
    1265                 1270                 1275             


Glu Tyr  Phe Val Phe Pro Asn  Glu Ala Thr Gly Phe  Ile Pro Ser 
    1280                 1285                 1290             


Glu Val  Asp Leu Thr Asp Glu  Ala Asn Tyr Gly Ile  Ile Ser Pro 
    1295                 1300                 1305             


Asn Leu  Tyr Arg Val Gln Lys  Met Ser Arg Ile Glu  Lys Gly Thr 
    1310                 1315                 1320             


Ser Val  Ser Arg Asp Tyr Trp  Phe Arg His His Leu  Glu Thr Ile 
    1325                 1330                 1335             


Leu Asn  Asp Asp Ser Arg Leu  Lys Asn Ser Ala Phe  Lys Arg Ile 
    1340                 1345                 1350             


Asn Ser  Leu Lys Pro Leu Glu  Gly Ile Ile Lys Val  Arg Ile Asn 
    1355                 1360                 1365             


Ser Ile  Gly Lys Ile Val Ala  Val Gly Glu Tyr Asp  
    1370                 1375                 1380 


<210> 396
<211> 1391
<212> PRT
<213> Prevotella oralis


<220>
<223> Prevotella oralis ATCC 33269

<400> 396
Met Lys Lys Ile Leu Gly Leu Asp Leu Gly Thr Thr Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Asn Glu Lys Glu Asn Asn Glu Glu Leu Ser Ser Ile Ile 
            20                  25                  30          


Arg Leu Gly Val Arg Val Asn Pro Leu Thr Val Asp Glu Lys Ser Asn 
        35                  40                  45              


Phe Glu Lys Gly Lys Asp Ile Thr Thr Asn Ala Asp Arg Thr Lys Cys 
    50                  55                  60                  


Arg Ser Ala Arg Arg Asn Leu Gln Arg Phe Lys Leu Arg Arg Glu Ala 
65                  70                  75                  80  


Leu Ala Asp Cys Leu Lys Arg His Gly Leu Met Thr Asp Glu Thr Pro 
                85                  90                  95      


Leu Cys Glu Thr Asn Asn Ser Ile Ile Phe Lys Thr Tyr Ser Asn Arg 
            100                 105                 110         


Ala Lys Ala Val Cys Glu Lys Ile Ala Leu Asp Asp Phe Val Arg Val 
        115                 120                 125             


Leu Phe Met Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Leu 
    130                 135                 140                 


Asn Thr Asp Asp Glu Gly Thr Leu Val Asp Gly Met Asp Val Ala Lys 
145                 150                 155                 160 


Leu Leu Tyr Asn Glu Gln Ile Thr Pro Gly Glu Tyr Leu Leu Arg Leu 
                165                 170                 175     


Phe Lys Lys Gly Lys Lys Thr Arg Pro Asp Phe Tyr Leu Ser Asp Leu 
            180                 185                 190         


Lys Ala Glu Leu Glu Arg Ile Trp Asp Phe Gln Arg Thr Phe Tyr Pro 
        195                 200                 205             


Glu Ile Leu Cys Asn Ala Leu Lys Glu Asp Leu Lys Gly Lys Ser Arg 
    210                 215                 220                 


Thr Gln Ser Ser Ala Ile Phe Tyr Ala Lys Tyr Lys Val Ser Thr Ala 
225                 230                 235                 240 


Lys Ile Ala Gly Lys Asp Lys Arg Leu Gln Glu Leu Thr Trp Arg Thr 
                245                 250                 255     


Asp Ala Leu Arg Lys Gln Leu Thr Ile Asp Glu Val Ala Tyr Val Ile 
            260                 265                 270         


Cys Ser Ile Asn Gly Glu Val Asn Gly Ser Ser Gln Arg Leu Ser Met 
        275                 280                 285             


Ile Ser Asp Arg Ser Lys Leu Leu Tyr Phe Asn His Gln Thr Ile Gly 
    290                 295                 300                 


Gln Tyr Leu Met Gln Arg Leu Glu Glu Asn Pro Asn Ala Gly Leu Lys 
305                 310                 315                 320 


Asn Ile Ile Phe Tyr Arg Gln Asp Tyr Glu Asp Glu Phe Asn Asp Ile 
                325                 330                 335     


Trp Asn Ser Gln Ala Thr Tyr His Lys Glu Leu Thr Pro Glu Leu Lys 
            340                 345                 350         


Lys Glu Val Lys Asp Ile Ile Phe Tyr Gln Arg Gly Leu Lys Ser Cys 
        355                 360                 365             


Lys Trp Leu Ile Asn Tyr Cys Glu Leu Glu His Glu Glu Ile Glu Val 
    370                 375                 380                 


Lys Thr Pro Glu Gly Lys Leu Arg Lys Ile Thr Ile Gly Ser Lys Thr 
385                 390                 395                 400 


Cys Pro Lys Ser Ser Pro Leu Phe Gln Glu Phe Lys Ile Trp Gln Val 
                405                 410                 415     


Leu Asn Asn Leu Gln Val Ser Pro Leu Asn Ser Arg Arg Lys Ala Lys 
            420                 425                 430         


Arg Lys Lys Asp Glu Glu Pro Ser Leu Phe Ser Asp Glu Asp Met Asn 
        435                 440                 445             


Thr Ala Cys Arg Tyr Leu Asn Glu Glu Glu Lys Leu Thr Leu Phe Lys 
    450                 455                 460                 


Glu Leu Ser Ile Lys Lys Glu Leu Lys Lys Lys Asp Ala Leu Lys Leu 
465                 470                 475                 480 


Leu Phe Glu Asn Tyr Lys Glu Leu Asp Leu Asn Tyr Lys Val Ile Ser 
                485                 490                 495     


Gly Asn Val Thr Met Ala Asn Leu Tyr Arg Ala Phe Gln Asp Ile Ile 
            500                 505                 510         


Ser Leu Thr Gly Asn Gly Glu Phe Asp Phe Gln Ala Met Pro Ala Glu 
        515                 520                 525             


Glu Ala Glu Lys Thr Val Glu Glu Ile Phe Gly Gly Leu Gly Tyr Lys 
    530                 535                 540                 


Thr Ala Phe Leu His Phe Asp Ala Ser Leu His Asp Lys Glu Phe Glu 
545                 550                 555                 560 


Arg Gln Pro Ala Tyr Arg Leu Trp His Leu Leu Tyr Ser Tyr Ala Gly 
                565                 570                 575     


Asp Gln Ser Lys Thr Gly Ile Glu Ala Leu Val Lys Arg Ile Gln Glu 
            580                 585                 590         


Leu Cys Gly Phe Glu Pro Glu Tyr Ala Arg Ile Leu Ala Asn Ile Ser 
        595                 600                 605             


Phe Ile Pro Asp Tyr Gly Asn Leu Ser Ser Lys Ala Met Arg Lys Ile 
    610                 615                 620                 


Leu Pro Tyr Met Gln Asp Gly Tyr Glu Tyr Ser Glu Ala Cys Ser Lys 
625                 630                 635                 640 


Ala Gly Tyr Arg His Ser Ala Ser Ser Leu Thr Lys Glu Glu Ile Asn 
                645                 650                 655     


Lys Lys Asn Tyr Lys Thr His Leu Asp Glu Ile Lys Arg Asn Ser Leu 
            660                 665                 670         


Arg Asn Pro Ile Val Glu Lys Ile Leu Asn Gln Met Val Asn Val Val 
        675                 680                 685             


Asn Ser Val Ile Asp Thr Tyr Ser Asn Ile Asp Glu Ile Arg Ile Glu 
    690                 695                 700                 


Met Ala Arg Glu Leu Lys Lys Ser Lys Pro Glu Arg Glu Asp Met Ser 
705                 710                 715                 720 


Phe Ala Ile Ser Lys Ala Thr Lys Glu Thr Glu Arg Ile Lys Gly Ile 
                725                 730                 735     


Leu Glu Gln Glu Phe Lys Ile Gln His Val Thr Arg Asn Asp Ile Ile 
            740                 745                 750         


Arg Tyr Arg Leu Tyr Glu Glu Leu Lys Pro Asn Gly Tyr Lys Thr Leu 
        755                 760                 765             


Tyr Ser Asn Thr Tyr Ile Pro Arg Glu Asp Leu Phe Ser Lys Lys Phe 
    770                 775                 780                 


Asp Ile Glu His Ile Ile Pro Lys Ala Arg Leu Phe Asp Asp Ser Tyr 
785                 790                 795                 800 


Ser Asn Lys Thr Leu Glu Leu Arg Asp Ile Asn Ile Glu Lys Gly Asn 
                805                 810                 815     


Gln Thr Ala Tyr Asp Phe Val Leu Ser Lys Tyr Gly Glu Glu Gly Leu 
            820                 825                 830         


Tyr Lys Tyr Glu Gln Arg Val Glu Glu Phe Lys Lys Asn Asn Glu Gln 
        835                 840                 845             


Ala Gly Thr Lys Cys Arg Lys Leu Leu Met Arg Glu Ala Asp Ile Pro 
    850                 855                 860                 


Ser Asp Phe Leu Asn Arg Asp Leu Asn Asp Ser Gln Tyr Ile Ala Lys 
865                 870                 875                 880 


Lys Ala His Glu Leu Leu Arg Glu Ile Val Pro Thr Val Thr Ala Thr 
                885                 890                 895     


Thr Gly Ser Ile Thr Asn Arg Leu Arg Glu Asp Trp Lys Leu Val Asn 
            900                 905                 910         


Val Met Lys Glu Leu Asn Trp Glu Lys Tyr Asp Lys Leu Gly Leu Thr 
        915                 920                 925             


Glu Glu Tyr Lys Asp Lys Asp Gly Asn Thr Val Arg His Ile Lys Asp 
    930                 935                 940                 


Trp Thr Lys Arg Asn Asp His Arg His His Ala Met Asp Ala Leu Thr 
945                 950                 955                 960 


Ile Ala Phe Thr Lys Pro Ser Phe Ile Gln Tyr Leu Asn Asn Leu Asn 
                965                 970                 975     


Ala Arg Ser Asn Arg Gly Gly Ser Ile Tyr Gly Ile Glu Gln Lys Glu 
            980                 985                 990         


Leu Glu Arg Glu Asn Asn Lys Leu  Val Phe Ile Pro Pro  Ile Asp Pro 
        995                 1000                 1005             


Lys Ile  Phe Arg Lys Gln Ala  Lys Glu His Leu Ser  Asn Ile Leu 
    1010                 1015                 1020             


Ile Ser  Ile Lys Ala Lys Asn  Lys Val Val Thr Lys  Asn Val Asn 
    1025                 1030                 1035             


Lys Thr  Lys Ser Lys Ser Gly  Thr Asn Arg Lys Val  Gln Leu Thr 
    1040                 1045                 1050             


Pro Arg  Gly Gln Leu His Leu  Glu Thr Val Tyr Gly  Lys Ile Arg 
    1055                 1060                 1065             


Thr Tyr  Lys Thr Glu Glu Ile  Lys Val Gly Thr Lys  Leu Thr Glu 
    1070                 1075                 1080             


Glu Leu  Ile Ala Lys Val Ala  Asp Lys Lys Ile Arg  Glu Ala Leu 
    1085                 1090                 1095             


Met Gln  Arg Leu Ser Glu Tyr  Gly Gly Asn Ile Lys  Lys Ala Phe 
    1100                 1105                 1110             


Gln Asn  Ile Ser Lys His Pro  Ile Trp Leu Asn Gly  Ser His Thr 
    1115                 1120                 1125             


Lys His  Val Pro Glu Lys Val  Lys Ile Val Phe Phe  Glu Asp Val 
    1130                 1135                 1140             


Phe Thr  Ile Arg Lys Ala Ile  Thr Pro Asp Ile Lys  Ile Asp Lys 
    1145                 1150                 1155             


Val Ile  Asp Ser Lys Ile Arg  Arg Ile Leu Gln Glu  Arg Leu Asn 
    1160                 1165                 1170             


Glu Phe  Gly Gly Glu Ala Ser  Lys Ala Phe Ser Asn  Leu Asp Glu 
    1175                 1180                 1185             


Asn Pro  Ile Trp Phe Asn Arg  Asp Lys Gly Ile Ala  Ile Lys Ser 
    1190                 1195                 1200             


Val Lys  Ile Arg Gly Ile Ala  Lys Gly Thr Ala Ile  Arg Val Lys 
    1205                 1210                 1215             


Lys Asp  Ile His Gly Lys Thr  Ile Ile Gly Asn Asn  Gly Tyr Pro 
    1220                 1225                 1230             


Val Ala  Asn Asp Tyr Val Asn  Thr Gly Asn Asn His  His Val Ala 
    1235                 1240                 1245             


Ile Phe  Arg Asp Lys Asp Gly  Asn Leu Gln Glu His  Ile Val Ser 
    1250                 1255                 1260             


Phe Tyr  Glu Ala Thr Ala Arg  Ala Ile Gln Asn Leu  Pro Ile Val 
    1265                 1270                 1275             


Asp Arg  Asn Tyr Asn Ser Glu  Lys Asp Trp Lys Phe  Leu Phe Ser 
    1280                 1285                 1290             


Met Lys  Gln Asn Glu Tyr Phe  Val Phe Pro Asn Pro  Asn Thr Gly 
    1295                 1300                 1305             


Phe Asn  Pro Ser Glu Ile Ser  Leu Lys Asp Glu Lys  Asn Tyr Ala 
    1310                 1315                 1320             


Leu Ile  Ser Pro Asn Leu Phe  Arg Val Gln Lys Leu  Ser His Tyr 
    1325                 1330                 1335             


Tyr Tyr  Val Phe Arg His His  Leu Glu Thr Asn Val  Asp Thr Asn 
    1340                 1345                 1350             


Leu Gln  Leu Lys Asp Ile Thr  Trp Lys Arg Ile Thr  Ala Val Asn 
    1355                 1360                 1365             


Asn Leu  Thr Gly Ala Val Lys  Val Arg Ile Asp His  Leu Gly Arg 
    1370                 1375                 1380             


Ile Val  Asp Val Gly Glu Tyr  Lys 
    1385                 1390     


<210> 397
<211> 1204
<212> PRT
<213> Prevotella ruminicola

<400> 397
Met Glu Arg Ile Leu Gly Ile Asp Thr Gly Thr Asn Ser Leu Gly Trp 
1               5                   10                  15      


Ala Ile Val Asp Lys Asp Glu Asn Gln Tyr His Leu Val Ala Lys Gly 
            20                  25                  30          


Thr Asn Ile Phe Ser Glu Gly Val Lys Ile Glu Lys Gly Ile Glu Ser 
        35                  40                  45              


Ser Lys Ala Ala Glu Arg Thr Glu His Arg Ser Val Arg Lys His Tyr 
    50                  55                  60                  


Trp Arg Arg Lys Ile Arg Lys Ile Arg Leu Leu Thr Ile Leu Ser Asp 
65                  70                  75                  80  


Asn Asp Leu Cys Pro Arg Leu Lys His Glu Gln Leu Arg Gln Trp Arg 
                85                  90                  95      


Leu Lys Lys Val Tyr Pro Thr Asp Asp Thr Phe Met Glu Trp Gln Arg 
            100                 105                 110         


Thr Glu Asp Lys Ala Gln Val Asn Pro Tyr Lys Phe Arg Tyr Ile Cys 
        115                 120                 125             


Leu Thr Gln Lys Leu Asp Leu Ser Asp Ile Thr Gln Arg Phe Ile Leu 
    130                 135                 140                 


Gly Arg Ala Leu Tyr His Leu Asn Gln Arg Arg Gly Phe Leu Ser Asn 
145                 150                 155                 160 


Arg Lys Glu Ala Thr Lys Glu Ser Glu Gly Thr Val Lys Glu Gly Ile 
                165                 170                 175     


Ser Ser Leu Ser Lys Asp Met Lys Asp Ser Gly Cys Glu Tyr Leu Gly 
            180                 185                 190         


Glu Tyr Phe Tyr Gln Leu Tyr Gln Gln Gly Lys Lys Ile Arg Asn His 
        195                 200                 205             


Tyr Thr Ala Arg Lys Glu His Tyr Leu Lys Glu Phe Lys Ala Ile Cys 
    210                 215                 220                 


Ser Lys Gln Glu Leu Asp Asp Ala Leu Ile Glu Lys Leu Glu Lys Ala 
225                 230                 235                 240 


Ile Phe Asp Gln Arg Pro Leu Lys Ser Gln Lys Gly Gln Val Gly Thr 
                245                 250                 255     


Cys Thr Phe Glu Lys Gly Lys Ser Arg Cys Pro Ser Ser His Pro Leu 
            260                 265                 270         


Tyr Glu Asp Phe Arg Met Tyr Ser Phe Ile Asn Asn Ile Lys Val Gln 
        275                 280                 285             


Val Asp Thr Leu Tyr Asp Lys Gly Glu Arg Ser Leu Thr Asp Glu Glu 
    290                 295                 300                 


Lys Gln Leu Ile Ile Pro Leu Phe Lys Arg Lys Ser Lys Arg Thr Phe 
305                 310                 315                 320 


Pro Phe Glu Asp Ile Ala Lys Lys Ile Ala Gly Lys Asn Asn Tyr Cys 
                325                 330                 335     


Tyr Ile Lys Ser Asn Glu Glu Lys Ala Tyr Lys Phe Asn Tyr Gln Met 
            340                 345                 350         


Asp Thr Gln Val Ser Gly Ser Pro Val Asn Ala Gln Leu Glu Glu Ile 
        355                 360                 365             


Phe Gly Glu Asp Trp Leu Ser Ser Val Cys Glu Val Tyr Thr Leu Ala 
    370                 375                 380                 


Asn Asn Lys Ser Arg Phe Gln Ile Met Asn Asp Val Trp His Val Leu 
385                 390                 395                 400 


Phe Phe Tyr Asp Asp Glu Asp Lys Leu Lys Glu Phe Ala Lys Asp Arg 
                405                 410                 415     


Leu Gln Leu Asp Asp Glu Leu Ala Glu Lys Phe Ser Lys Ile Ser Ile 
            420                 425                 430         


Pro Asn Asp Tyr Ala Ala Leu Ser Leu Lys Ala Ile Arg Lys Ile Met 
        435                 440                 445             


Pro Tyr Leu Arg Asp Tyr Gly Leu Ile Tyr Ser Glu Ala Val Phe Leu 
    450                 455                 460                 


Ala Asn Leu Val Asp Val Leu Pro Gln His Val Trp Gly Ile Lys Glu 
465                 470                 475                 480 


Met Arg Glu Ala Ala Ile Glu Asn Val Ile Asp Val Met His Ser Tyr 
                485                 490                 495     


Asp Lys Asn Asn Ile Asp Gly Ile Thr Leu Glu Gly Cys Val Lys Thr 
            500                 505                 510         


Phe Leu Lys Glu Arg Tyr Gln Val Ser Asp Asp Asn Leu Lys Lys Leu 
        515                 520                 525             


Tyr His Pro Ser Met Leu Asp Pro Tyr Pro Arg Gln Arg Pro Asn Asp 
    530                 535                 540                 


Glu Gly Val Phe Gln Leu Gly Ser Pro Arg Ile Ser Ser Val Lys Asn 
545                 550                 555                 560 


Pro Met Ala Met His Ser Leu Phe Arg Leu Arg Lys Val Val Asn Leu 
                565                 570                 575     


Met Leu Lys Lys Gly Tyr Ile Thr Pro Asp Thr Lys Val His Ile Glu 
            580                 585                 590         


Phe Ser Arg Asp Leu Asn Asp Ala Asn Lys Arg Trp Ala Ile Gln Thr 
        595                 600                 605             


Trp Gln Arg Glu Asn Glu Lys Glu Arg Glu Arg Cys Arg Lys Glu Ile 
    610                 615                 620                 


Glu Lys Tyr Ile Ala Ser Pro Ser Asp Thr Asp Ile Leu Lys Tyr Gln 
625                 630                 635                 640 


Leu Trp Glu Glu Gln Asn His Lys Cys Leu Tyr Thr Gly Asp Glu Ile 
                645                 650                 655     


Arg Ile Thr Asp Phe Leu Gly Asp Asn Pro Lys Tyr Asp Ile Glu His 
            660                 665                 670         


Thr Ile Pro Arg Ser Ala Gly Gly Asp Ser Thr Lys Met Asn Leu Thr 
        675                 680                 685             


Leu Cys Ser Ser Arg Phe Asn Arg Asp Glu Lys Lys Thr Lys Leu Pro 
    690                 695                 700                 


Ala Glu Leu Val Asn His Asp Glu Ile Leu Glu Arg Ile Ser Asn Trp 
705                 710                 715                 720 


Lys Glu Lys Tyr Glu Asp Ile Asp Lys Gln Ile Arg Lys Ile Ser Thr 
                725                 730                 735     


Lys Gly Ala Thr Ser Lys Glu Asp Lys Asp Ser Lys Ile Arg Arg Arg 
            740                 745                 750         


His Tyr Leu Ile Leu Gln Arg Asp Tyr Trp Arg Gly Lys Tyr Gln Arg 
        755                 760                 765             


Phe Thr Met Thr Glu Val Pro Glu Gly Phe Ser Arg Arg Gln Gly Thr 
    770                 775                 780                 


Asp Ile Ser Val Ile Ser Arg Tyr Ala Arg Met Tyr Leu Lys Ser Val 
785                 790                 795                 800 


Phe Lys Gln Val Tyr Ile Val Lys Gly Ile Ala Thr Ser Asp Phe Arg 
                805                 810                 815     


Lys Met Trp Gly Ile Gln Asp Glu Tyr Ala Lys Lys Glu Arg Val Asn 
            820                 825                 830         


His Val His His Cys Ile Asp Ala Ile Thr Ile Ala Cys Ile Gly Lys 
        835                 840                 845             


Ala Glu Tyr Asp Lys Leu Ala Asp Tyr Arg His Gln Tyr Asp Asp Tyr 
    850                 855                 860                 


Leu Phe Gln Gly Lys Thr Lys Pro Thr Phe Asp Lys Pro Trp Pro Ser 
865                 870                 875                 880 


Phe Val Ile Asp Ile Lys His Ile Gln Asp Glu Leu Leu Ile Ala His 
                885                 890                 895     


Tyr Ala Lys Asp Asn Leu Glu Lys Phe Thr Lys Lys Asn Leu Arg Gly 
            900                 905                 910         


Lys Asp Gly Arg Ile Ile Arg Asp Lys Phe Gly Asn Lys Leu Gln Met 
        915                 920                 925             


Lys Gly Asp Thr Ser Arg Asn Ser Leu His Asn Asp Lys Phe Tyr Gly 
    930                 935                 940                 


Ala Ile Asn His Glu Gly Glu Ile Lys Tyr Val Tyr Arg Thr Asn Ile 
945                 950                 955                 960 


Glu Ala Leu Asp Ala Lys Ser Ile Gly Asn Ile Val Asp Pro Thr Val 
                965                 970                 975     


Arg Ser Ile Ile Glu Ser Ala Ile Ala Ile His Gly Ser Leu Lys Ala 
            980                 985                 990         


Ala Ile Asn Lys Gly Ile Trp Met  Asn Glu Glu Lys His  Ile Pro Ile 
        995                 1000                 1005             


Lys Lys  Val Arg Val Phe Arg  Asn Asp Val Lys Lys  Pro Ile Glu 
    1010                 1015                 1020             


Leu Lys  Asp Gln Arg Asp Leu  Ser Asp Lys Asp Tyr  Lys Gln His 
    1025                 1030                 1035             


Tyr Tyr  Val Thr Asn Asp Gly  Asn Tyr Met Met Leu  Ile Phe Ser 
    1040                 1045                 1050             


Lys Leu  Asn Asn Lys Gly Arg  Glu Ile Arg Gln His  Val Val Ile 
    1055                 1060                 1065             


Asn Ser  Leu Glu Ala Thr Glu  Val Ile Lys Ser His  Lys Arg Ser 
    1070                 1075                 1080             


Gln Val  Gly Lys Val Val Trp  Glu Ser Tyr Tyr Ser  Lys Glu Gly 
    1085                 1090                 1095             


Phe Asp  Leu Ile Tyr Lys Leu  Lys Ser Gly Thr Met  Ile Leu Leu 
    1100                 1105                 1110             


Tyr Glu  Asn Asn Arg Asp Glu  Val Trp Asp Leu Asp  Ile Arg Asn 
    1115                 1120                 1125             


Leu Gln  Lys Arg Leu Tyr Ile  Ile Thr Lys Met Lys  Tyr Asp Gly 
    1130                 1135                 1140             


Arg Ile  Tyr Met Met His His  Gln Glu Ala Arg Glu  Lys Lys Asp 
    1145                 1150                 1155             


Leu Glu  Glu Lys Ser Gly Ser  Phe Lys Ile Asn Glu  Asp Tyr Arg 
    1160                 1165                 1170             


Pro Leu  Ile Val Asn Ser Tyr  Asn Gln Phe Asn Ala  Leu Val Gln 
    1175                 1180                 1185             


Asp Leu  Asp Phe Glu Ile Asn  Asp Leu Gly Glu Ile  Arg Arg Leu 
    1190                 1195                 1200             


Ile 
    


<210> 398
<211> 1424
<212> PRT
<213> Prevotella sp.


<220>
<223> Prevotella sp. C561

<400> 398
Met Thr Gln Lys Val Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly 
1               5                   10                  15      


Ser Ala Val Arg Asn Leu Asp Leu Ser Asp Asp Leu Gln Trp Gln Leu 
            20                  25                  30          


Glu Phe Phe Ser Ser Asp Ile Phe Arg Ser Ser Val Asn Lys Glu Ser 
        35                  40                  45              


Asn Gly Arg Glu Tyr Ser Leu Ala Ala Gln Arg Ser Ala His Arg Arg 
    50                  55                  60                  


Ser Arg Gly Leu Asn Glu Val Arg Arg Arg Arg Leu Trp Ala Thr Leu 
65                  70                  75                  80  


Asn Leu Leu Ile Lys His Gly Phe Cys Pro Met Ser Ser Glu Ser Leu 
                85                  90                  95      


Met Arg Trp Cys Thr Tyr Asp Lys Arg Lys Gly Leu Phe Arg Glu Tyr 
            100                 105                 110         


Pro Ile Asp Asp Lys Asp Phe Asn Ala Trp Ile Leu Leu Asp Phe Asn 
        115                 120                 125             


Gly Asp Gly Arg Pro Asp Tyr Ser Ser Pro Tyr Gln Leu Arg Arg Glu 
    130                 135                 140                 


Leu Val Thr Arg Gln Phe Asp Phe Glu Gln Pro Ile Glu Arg Tyr Lys 
145                 150                 155                 160 


Leu Gly Arg Ala Leu Tyr His Ile Ala Gln His Arg Gly Phe Lys Ser 
                165                 170                 175     


Ser Lys Gly Glu Thr Leu Ser Gln Gln Glu Thr Asn Ser Lys Pro Ser 
            180                 185                 190         


Ser Thr Asp Glu Ile Pro Asp Val Ala Gly Ala Met Lys Ala Ser Glu 
        195                 200                 205             


Glu Lys Leu Ser Lys Gly Leu Ser Thr Tyr Met Lys Glu His Asn Leu 
    210                 215                 220                 


Leu Thr Val Gly Ala Ala Phe Ala Gln Leu Glu Asp Glu Gly Val Arg 
225                 230                 235                 240 


Val Arg Asn Asn Asn Asp Tyr Arg Ala Ile Arg Ser Gln Phe Gln His 
                245                 250                 255     


Glu Ile Glu Thr Ile Phe Lys Phe Gln Gln Gly Leu Ser Val Glu Ser 
            260                 265                 270         


Glu Leu Tyr Glu Arg Leu Ile Ser Glu Lys Lys Asn Val Gly Thr Ile 
        275                 280                 285             


Phe Tyr Lys Arg Pro Leu Arg Ser Gln Arg Gly Asn Val Gly Lys Cys 
    290                 295                 300                 


Thr Leu Glu Arg Ser Lys Pro Arg Cys Ala Ile Gly His Pro Leu Phe 
305                 310                 315                 320 


Glu Lys Phe Arg Ala Trp Thr Leu Ile Asn Asn Ile Lys Val Arg Met 
                325                 330                 335     


Ser Val Asp Thr Leu Asp Glu Gln Leu Pro Met Lys Leu Arg Leu Asp 
            340                 345                 350         


Leu Tyr Asn Glu Cys Phe Leu Ala Phe Val Arg Thr Glu Phe Lys Phe 
        355                 360                 365             


Glu Asp Ile Arg Lys Tyr Leu Glu Lys Arg Leu Gly Ile His Phe Ser 
    370                 375                 380                 


Tyr Asn Asp Lys Thr Ile Asn Tyr Lys Asp Ser Thr Ser Val Ala Gly 
385                 390                 395                 400 


Cys Pro Ile Thr Ala Arg Phe Arg Lys Met Leu Gly Glu Glu Trp Glu 
                405                 410                 415     


Ser Phe Arg Val Glu Gly Gln Lys Glu Arg Gln Ala His Ser Lys Asn 
            420                 425                 430         


Asn Ile Ser Phe His Arg Val Ser Tyr Ser Ile Glu Asp Ile Trp His 
        435                 440                 445             


Phe Cys Tyr Asp Ala Glu Glu Pro Glu Ala Val Leu Ala Phe Ala Gln 
    450                 455                 460                 


Glu Thr Leu Arg Leu Glu Arg Lys Lys Ala Glu Glu Leu Val Arg Ile 
465                 470                 475                 480 


Trp Ser Ala Met Pro Gln Gly Tyr Ala Met Leu Ser Gln Lys Ala Ile 
                485                 490                 495     


Arg Asn Ile Asn Lys Ile Leu Met Leu Gly Leu Lys Tyr Ser Asp Ala 
            500                 505                 510         


Val Ile Leu Ala Lys Val Pro Glu Leu Val Asp Val Ser Asp Glu Glu 
        515                 520                 525             


Leu Leu Ser Ile Ala Lys Asp Tyr Tyr Leu Val Glu Ala Gln Val Asn 
    530                 535                 540                 


Tyr Asp Lys Arg Ile Asn Ser Ile Val Asn Gly Leu Ile Ala Lys Tyr 
545                 550                 555                 560 


Lys Ser Val Ser Glu Glu Tyr Arg Phe Ala Asp His Asn Tyr Glu Tyr 
                565                 570                 575     


Leu Leu Asp Glu Ser Asp Glu Lys Asp Ile Ile Arg Gln Ile Glu Asn 
            580                 585                 590         


Ser Leu Gly Ala Arg Arg Trp Ser Leu Met Asp Ala Asn Glu Gln Thr 
        595                 600                 605             


Asp Ile Leu Gln Lys Val Arg Asp Arg Tyr Gln Asp Phe Phe Arg Ser 
    610                 615                 620                 


His Glu Arg Lys Phe Val Glu Ser Pro Lys Leu Gly Glu Ser Phe Glu 
625                 630                 635                 640 


Asn Tyr Leu Thr Lys Lys Phe Pro Met Val Glu Arg Glu Gln Trp Lys 
                645                 650                 655     


Lys Leu Tyr His Pro Ser Gln Ile Thr Ile Tyr Arg Pro Val Ser Val 
            660                 665                 670         


Gly Lys Asp Arg Ser Val Leu Arg Leu Gly Asn Pro Asp Ile Gly Ala 
        675                 680                 685             


Ile Lys Asn Pro Thr Val Leu Arg Val Leu Asn Thr Leu Arg Arg Arg 
    690                 695                 700                 


Val Asn Gln Leu Leu Asp Asp Gly Val Ile Ser Pro Asp Glu Thr Arg 
705                 710                 715                 720 


Val Val Val Glu Thr Ala Arg Glu Leu Asn Asp Ala Asn Arg Lys Trp 
                725                 730                 735     


Ala Leu Asp Thr Tyr Asn Arg Ile Arg His Asp Glu Asn Glu Lys Ile 
            740                 745                 750         


Lys Lys Ile Leu Glu Glu Phe Tyr Pro Lys Arg Asp Gly Ile Ser Thr 
        755                 760                 765             


Asp Asp Ile Asp Lys Ala Arg Tyr Val Ile Asp Gln Arg Glu Val Asp 
    770                 775                 780                 


Tyr Phe Thr Gly Ser Lys Thr Tyr Asn Lys Asp Ile Lys Lys Tyr Lys 
785                 790                 795                 800 


Phe Trp Leu Glu Gln Gly Gly Gln Cys Met Tyr Thr Gly Arg Thr Ile 
                805                 810                 815     


Asn Leu Ser Asn Leu Phe Asp Pro Asn Ala Phe Asp Ile Glu His Thr 
            820                 825                 830         


Ile Pro Glu Ser Leu Ser Phe Asp Ser Ser Asp Met Asn Leu Thr Leu 
        835                 840                 845             


Cys Asp Ala His Tyr Asn Arg Phe Ile Lys Lys Asn His Ile Pro Thr 
    850                 855                 860                 


Asp Met Pro Asn Tyr Asp Lys Ala Ile Thr Ile Asp Gly Lys Glu Tyr 
865                 870                 875                 880 


Pro Ala Ile Thr Ser Gln Leu Gln Arg Trp Val Glu Arg Val Glu Arg 
                885                 890                 895     


Leu Asn Arg Asn Val Glu Tyr Trp Lys Gly Gln Ala Arg Arg Ala Gln 
            900                 905                 910         


Asn Lys Asp Arg Lys Asp Gln Cys Met Arg Glu Met His Leu Trp Lys 
        915                 920                 925             


Met Glu Leu Glu Tyr Trp Lys Lys Lys Leu Glu Arg Phe Thr Val Thr 
    930                 935                 940                 


Glu Val Thr Asp Gly Phe Lys Asn Ser Gln Leu Val Asp Thr Arg Val 
945                 950                 955                 960 


Ile Thr Arg His Ala Val Leu Tyr Leu Lys Ser Ile Phe Pro His Val 
                965                 970                 975     


Asp Val Gln Arg Gly Asp Val Thr Ala Lys Phe Arg Lys Ile Leu Gly 
            980                 985                 990         


Ile Gln Ser Val Asp Glu Lys Lys  Asp Arg Ser Leu His  Ser His His 
        995                 1000                 1005             


Ala Ile  Asp Ala Thr Thr Leu  Thr Ile Ile Pro Val  Ser Ala Lys 
    1010                 1015                 1020             


Arg Asp  Arg Met Leu Glu Leu  Phe Ala Lys Ile Glu  Glu Ile Asn 
    1025                 1030                 1035             


Lys Met  Leu Ser Phe Ser Gly  Ser Glu Asp Arg Thr  Gly Leu Ile 
    1040                 1045                 1050             


Gln Glu  Leu Glu Gly Leu Lys  Asn Lys Leu Gln Met  Glu Val Lys 
    1055                 1060                 1065             


Val Cys  Arg Ile Gly His Asn  Val Ser Glu Ile Gly  Thr Phe Ile 
    1070                 1075                 1080             


Asn Asp  Asn Ile Ile Val Asn  His His Ile Lys Asn  Gln Ala Leu 
    1085                 1090                 1095             


Thr Pro  Val Arg Arg Arg Leu  Arg Lys Lys Gly Tyr  Ile Val Gly 
    1100                 1105                 1110             


Gly Val  Asp Asn Pro Arg Trp  Gln Thr Gly Asp Ala  Leu Arg Gly 
    1115                 1120                 1125             


Glu Ile  His Lys Ala Ser Tyr  Tyr Gly Ala Ile Thr  Gln Phe Ala 
    1130                 1135                 1140             


Lys Asp  Asp Glu Gly Lys Val  Leu Met Lys Glu Gly  Arg Pro Gln 
    1145                 1150                 1155             


Val Asn  Pro Thr Ile Lys Phe  Val Ile Arg Arg Glu  Leu Lys Tyr 
    1160                 1165                 1170             


Lys Lys  Ser Ala Ala Asp Ser  Gly Phe Ala Ser Trp  Asp Asp Leu 
    1175                 1180                 1185             


Gly Lys  Ala Ile Val Asp Lys  Glu Leu Phe Ala Leu  Met Lys Gly 
    1190                 1195                 1200             


Gln Phe  Pro Ala Glu Thr Ser  Phe Lys Asp Ala Cys  Glu Gln Gly 
    1205                 1210                 1215             


Ile Tyr  Met Ile Lys Lys Gly  Lys Asn Gly Met Pro  Asp Ile Lys 
    1220                 1225                 1230             


Leu His  His Ile Arg His Val  Arg Cys Glu Ala Pro  Gln Ser Gly 
    1235                 1240                 1245             


Leu Lys  Ile Lys Glu Gln Thr  Tyr Lys Ser Glu Lys  Glu Tyr Lys 
    1250                 1255                 1260             


Arg Tyr  Phe Tyr Ala Ala Val  Gly Asp Leu Tyr Ala  Met Cys Cys 
    1265                 1270                 1275             


Tyr Thr  Asn Gly Lys Ile Arg  Glu Phe Arg Ile Tyr  Ser Leu Tyr 
    1280                 1285                 1290             


Asp Val  Ser Cys His Arg Lys  Ser Asp Ile Glu Asp  Ile Pro Glu 
    1295                 1300                 1305             


Phe Ile  Thr Asp Lys Lys Gly  Asn Arg Leu Met Leu  Asp Tyr Lys 
    1310                 1315                 1320             


Leu Arg  Thr Gly Asp Met Ile  Leu Leu Tyr Lys Asp  Asn Pro Ala 
    1325                 1330                 1335             


Glu Leu  Tyr Asp Leu Asp Asn  Val Asn Leu Ser Arg  Arg Leu Tyr 
    1340                 1345                 1350             


Lys Ile  Asn Arg Phe Glu Ser  Gln Ser Asn Leu Val  Leu Met Thr 
    1355                 1360                 1365             


His His  Leu Ser Thr Ser Lys  Glu Arg Gly Arg Ser  Leu Gly Lys 
    1370                 1375                 1380             


Thr Val  Asp Tyr Gln Asn Leu  Pro Glu Ser Ile Arg  Ser Ser Val 
    1385                 1390                 1395             


Lys Ser  Leu Asn Phe Leu Ile  Met Gly Glu Asn Arg  Asp Phe Val 
    1400                 1405                 1410             


Ile Lys  Asn Gly Lys Ile Ile  Phe Asn His Arg 
    1415                 1420                 


<210> 399
<211> 1483
<212> PRT
<213> Prevotella sp.


<220>
<223> Prevotella sp. MSX73

<400> 399
Met Lys Thr Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Lys Val Ser Val Asp Asp Tyr Gly Asn Tyr Leu His Asp Ile Lys 
            20                  25                  30          


Leu Gly Ser Arg Ile Ile Pro Met Ser Gln Asp Val Leu Gly Asn Phe 
        35                  40                  45              


Asp Ser Gly Val Thr Val Ser Gln Thr Ala Gln Arg Thr Glu Phe Arg 
    50                  55                  60                  


Ser Lys Arg Arg Leu Val Gln Arg Asn Leu Gln Arg Arg Glu Arg Leu 
65                  70                  75                  80  


His Arg Val Leu His Val Leu Asp Phe Leu Pro Ala His Tyr Asp Ala 
                85                  90                  95      


Ala Ile Gly Trp Asp Arg Thr Glu Ala Val Thr Tyr Gly Lys Phe Leu 
            100                 105                 110         


Asn His Ala Glu Pro Lys Leu Ala Trp Glu Glu Leu Gly Asn Gly Lys 
        115                 120                 125             


Arg Arg Phe Leu Phe Met Asp Ser Phe His Glu Met Val Ala Asp Phe 
    130                 135                 140                 


Ala Arg Cys Gln Pro Ala Leu Val Ala Asp Gly Lys Lys Ile Pro Leu 
145                 150                 155                 160 


Asp Trp Thr Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Thr Gln Ala Ile 
                165                 170                 175     


Thr Lys Glu Glu Leu Ala Trp Ile Leu Leu Asn Phe Asn Gln Lys Arg 
            180                 185                 190         


Gly Tyr Tyr Gln Leu Arg Gly Glu Glu Glu Glu Glu Asn Pro Thr Lys 
        195                 200                 205             


Gln Glu Glu Tyr Tyr Glu Leu Lys Val Val Ser Val Glu Ala Thr Asp 
    210                 215                 220                 


Ser Arg Lys Gly Asn Asp Thr Trp Tyr Asn Val His Leu Glu Asn Gly 
225                 230                 235                 240 


Trp Ile Tyr Arg Arg Ser Ser Lys Ile Ser Leu Asp Asp Trp Val Gly 
                245                 250                 255     


Lys Val Lys Gln Phe Ile Val Thr Thr Glu Tyr Glu Lys Asp Gly Thr 
            260                 265                 270         


Thr Leu Lys Thr Asp Lys Glu Gly Asn Val Lys Arg Ser Phe Arg Ala 
        275                 280                 285             


Pro Asn Glu Asn Asp Trp Gly Leu Arg Lys Lys Arg Thr Glu Thr Leu 
    290                 295                 300                 


Leu Glu Met Ser Gly Lys Thr Val Gly Ala Phe Ile Tyr Asp His Leu 
305                 310                 315                 320 


Leu Gln Glu Pro Ala Asp Lys Ile Arg Gly Asn Phe Ile Arg Thr Ile 
                325                 330                 335     


Glu Arg His Tyr Tyr Lys Ala Glu Leu Glu Ala Ile Leu Ala Glu Gln 
            340                 345                 350         


Cys Lys Tyr His Ile Glu Leu Arg Asp Lys Glu Met Leu Glu Ala Cys 
        355                 360                 365             


Ala Arg Glu Leu Tyr Leu Asn Asn Leu Pro His Gln Arg Ser Leu Met 
    370                 375                 380                 


Lys Lys Asp Met Thr Tyr Leu Leu Leu Tyr Asp Leu Ile Phe Tyr Gln 
385                 390                 395                 400 


Arg Pro Leu Lys Ser Lys Lys Ala Leu Ile Ala Asn Cys Pro Tyr Glu 
                405                 410                 415     


Tyr Tyr Glu Tyr Val Asp Lys Glu Thr Gly Glu Ile Lys Arg Gln Asn 
            420                 425                 430         


Ile Lys Cys Ile Ala Lys Ser Asn Pro Tyr Phe Gln Glu Phe Arg Leu 
        435                 440                 445             


Trp Gln Phe Val Leu Asn Leu Arg Leu Phe Asp Arg Val Glu Asp Lys 
    450                 455                 460                 


Glu Val Thr Ala Asn Tyr Leu Pro Thr Ala Asp Asp His Ala Arg Leu 
465                 470                 475                 480 


Phe Thr Tyr Leu Asn Asp Arg Lys Glu Ile Asn Gln Glu Thr Leu Leu 
                485                 490                 495     


Lys Asp Tyr Phe Lys Leu Lys Lys Val Lys Ile Gly Asn Glu Lys Glu 
            500                 505                 510         


Tyr Pro Ile Arg Trp Asn Tyr Ile Glu Asp Lys Glu Lys Lys Tyr Pro 
        515                 520                 525             


Cys Asn Glu Thr Arg Tyr Glu Leu Leu Met Ala Leu Asp Arg Ala Gly 
    530                 535                 540                 


Ile Glu His Lys Trp Leu Asp Asp Asn Asn Leu Glu Tyr Arg Leu Trp 
545                 550                 555                 560 


His Leu Leu Tyr Ser Val Glu Val Lys Ser Glu Ser Glu Thr Ala Leu 
                565                 570                 575     


Arg Lys Leu Lys Asn Asp Asp Ala Phe Val Asn Ser Phe Leu Lys Val 
            580                 585                 590         


Lys Pro Phe Lys Lys Glu Tyr Gly Ala Tyr Ser Glu Lys Ala Ile Lys 
        595                 600                 605             


Arg Leu Leu Ala Val Met Arg Lys Gly Phe Leu Trp Asn Glu Gln Asp 
    610                 615                 620                 


Ile Cys Asp Glu Thr Arg Lys Arg Ile Glu Ile Ile Ile Lys Gly Asp 
625                 630                 635                 640 


Val Asp Glu Lys Val Lys Glu Arg Met Gly His Ala Ala Tyr Ser Phe 
                645                 650                 655     


Asp Arg Val Ser Asp Phe Gln Gly Leu Pro Glu Trp Leu Ala Cys Tyr 
            660                 665                 670         


Val Val Tyr Gly Arg His Ser Glu Ala Met Asp Ile Gln Arg Trp Asp 
        675                 680                 685             


Ser Pro Glu Arg Leu Met Ala Tyr Ile Asn Asn Phe Lys Gln Tyr Ser 
    690                 695                 700                 


Leu Arg Asn Pro Ile Val Glu Gln Cys Ile Leu Glu Thr Leu Arg Thr 
705                 710                 715                 720 


Val His Asp Ile Trp Lys Glu Thr Gly Gln Ile Asp Glu Ile His Val 
                725                 730                 735     


Glu Leu Gly Arg Glu Met Lys Ser Thr Ser Glu Glu Arg Ala Arg Arg 
            740                 745                 750         


Thr Gln Asn Val Leu Arg Asn Glu Asn Thr Asn Leu Arg Ile Lys Ser 
        755                 760                 765             


Leu Leu Ile Glu Leu Lys Asn Asp Thr Asp Ile Cys Asn Val His Pro 
    770                 775                 780                 


Tyr Ser Pro Met Gln Gln Glu Ile Leu Arg Ile Tyr Glu Glu Gly Ala 
785                 790                 795                 800 


Leu Gln Glu Leu Asn Arg Glu Asp Glu Asp Phe Glu Glu Ile Ser Lys 
                805                 810                 815     


Ile Ser Gln Met Ser Gln Pro Ser Gly Lys Glu Leu Asn Arg Tyr Lys 
            820                 825                 830         


Leu Trp Leu Glu Gln Lys Tyr Arg Ser Pro Tyr Thr Gly Lys Ala Ile 
        835                 840                 845             


Ser Leu Ala Lys Leu Phe Thr Pro Ala Tyr Gln Ile Glu His Val Ile 
    850                 855                 860                 


Pro Gln Ser Arg Tyr Phe Asp Asp Ser Phe Thr Asn Lys Val Ile Cys 
865                 870                 875                 880 


Glu Ala Glu Val Asn Thr Leu Lys Ser Asn Leu Leu Gly Tyr Glu Phe 
                885                 890                 895     


Ile Lys Lys His Gly Gly Glu Ile Ile His Cys Thr Thr Leu Gly Asp 
            900                 905                 910         


Val Arg Ile Phe Ser Glu Ser Glu Tyr Lys Ala Phe Val Met Asp His 
        915                 920                 925             


Tyr Ala Asn Asn Lys Ser Lys Lys Asp Lys Leu Leu Met Glu Asp Ile 
    930                 935                 940                 


Pro Gln Glu Phe Leu Ser Arg Gln Met Asn Asp Ser Arg Tyr Ile Ser 
945                 950                 955                 960 


Lys Val Val Lys Thr Leu Leu Ser Asn Ile Val Arg Met Ala Asp Glu 
                965                 970                 975     


Ser Glu Ala Thr Ser Lys Ser Val Ile Val Cys Thr Gly Gly Val Thr 
            980                 985                 990         


Asp Arg Leu Lys Lys Asp Trp Gly  Leu Asn Asp Val Trp  Asn Ser Ile 
        995                 1000                 1005             


Val Tyr  Ser Arg Phe Glu Arg  Leu Asn Arg Leu Thr  Gly Thr Glu 
    1010                 1015                 1020             


Ala Phe  Gly His Trp Glu Asn  Lys Asp Gly Lys Arg  Val Phe Gln 
    1025                 1030                 1035             


Thr Ser  Met Pro Leu Glu Leu  Gln Arg Gly Phe Arg  Lys Lys Arg 
    1040                 1045                 1050             


Ile Asp  His Arg His His Ala  Met Asp Ala Leu Val  Ile Ala Cys 
    1055                 1060                 1065             


Ala Ser  Arg Asn Ile Val Asn  Tyr Leu Asn Asn Glu  Ser Ala Asn 
    1070                 1075                 1080             


Asn Pro  Lys Lys Arg Glu Asp  Leu Arg Arg Gln Leu  Cys Asp Lys 
    1085                 1090                 1095             


Asn Arg  Val Ile Arg Lys Pro  Trp Glu Thr Phe Thr  Gln Asp Ala 
    1100                 1105                 1110             


Tyr Asn  Ala Leu Glu Asn Val  Val Val Ser Phe Lys  Asn Tyr Val 
    1115                 1120                 1125             


Arg Val  Ile Asn Lys Ala Thr  Asn Arg Tyr Glu His  Tyr Asp Glu 
    1130                 1135                 1140             


Asn Gly  Lys Lys Arg Phe Val  Gln Gln Lys Gly Ser  Glu Leu Trp 
    1145                 1150                 1155             


Ala Ile  Arg Lys Pro Met His  Lys Glu Thr Tyr Tyr  Gly His Val 
    1160                 1165                 1170             


Asn Leu  Arg Arg Lys Glu Leu  Val Thr Leu Gln Lys  Ala Leu Asp 
    1175                 1180                 1185             


Asp Ile  Pro Ser Ile Cys Asp  Lys Lys Leu Arg Asp  Tyr Ile Ser 
    1190                 1195                 1200             


Ala Leu  Val Glu Lys His Phe  Asn Lys Arg Gln Leu  Leu Ala His 
    1205                 1210                 1215             


Phe Lys  Ser Thr Asp Tyr Tyr  Trp Gln Lys Gln Tyr  Val Asn Lys 
    1220                 1225                 1230             


Val Tyr  Val Trp Thr Phe Ser  Asp Asp Ile Lys Pro  Leu Val Ala 
    1235                 1240                 1245             


Thr Arg  Lys Leu Leu Asp Thr  Ser Phe Asp Ala Lys  Arg Ile Gly 
    1250                 1255                 1260             


Thr Ile  Thr Asp Thr Gly Ile  Gln Lys Ile Leu Arg  Asn Tyr Leu 
    1265                 1270                 1275             


Glu Ala  Lys Gly Gly Asn Ala  Thr Leu Ala Phe Thr  Pro Glu Gly 
    1280                 1285                 1290             


Ile Val  Glu Met Asn Gln Asn  Ile Ser Lys Tyr Asn  Asp Gly Lys 
    1295                 1300                 1305             


Pro His  Gln Pro Ile Leu Lys  Val Arg Ile Thr Glu  Pro Met Gly 
    1310                 1315                 1320             


Ala Lys  Tyr Arg Val Gly Gln  Thr Glu Asn Lys Met  Ala Lys Tyr 
    1325                 1330                 1335             


Val Glu  Ala Gln Ser Gly Thr  Asn Leu Tyr Phe Ala  Ile Tyr Glu 
    1340                 1345                 1350             


Asp Ser  Glu Gly Lys Arg Ser  Tyr Thr Thr Val Pro  Leu Asp Glu 
    1355                 1360                 1365             


Val Ala  Glu Arg Leu Lys Gln  Arg Leu Ser Pro Val  Pro Glu Lys 
    1370                 1375                 1380             


Asp Glu  Asn Asp Val Pro Leu  Lys Phe Tyr Leu Ser  Pro Asn Asp 
    1385                 1390                 1395             


Leu Val  Tyr Val Pro Thr Glu  Glu Glu Leu Gln Leu  Arg Glu Cys 
    1400                 1405                 1410             


Lys Leu  Asn Lys Asp Arg Ile  Tyr Lys Met Val Ser  Ser Thr Gly 
    1415                 1420                 1425             


Ser Glu  Cys His Phe Ile Pro  Tyr Tyr Val Ala Asn  Val Ile Tyr 
    1430                 1435                 1440             


Asn Lys  Val Glu Phe Glu Ala  Lys Asn Lys Ile Gly  Arg Ala Leu 
    1445                 1450                 1455             


Thr Gly  Glu Met Ile Lys Ala  Val Cys Trp Lys Leu  Glu Ile Asp 
    1460                 1465                 1470             


Arg Leu  Gly Asn Ile Leu Lys  Val Ile Lys 
    1475                 1480             


<210> 400
<211> 1375
<212> PRT
<213> Prevotella sp.


<220>
<223> Prevotella sp. oral taxon 306 str. F0472

<400> 400
Met Lys Lys Ile Leu Gly Leu Asp Leu Gly Thr Thr Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Asn Glu Ser Glu Asn Lys Asp Glu Gln Ser Ser Ile Val 
            20                  25                  30          


Arg Leu Gly Val Arg Val Ile Pro Leu Thr Val Asp Glu Lys Gly Asn 
        35                  40                  45              


Phe Glu Lys Gly Lys Ala Ile Thr Thr Asn Ala Asp Arg Gln Gln Val 
    50                  55                  60                  


His Ala Ala Arg Ile Asn Leu Gln Arg Tyr Lys Leu Arg Arg Glu Asn 
65                  70                  75                  80  


Leu Arg Asp Cys Leu Gln Lys Gln Gly Trp Ile Gly Ser Glu Pro Met 
                85                  90                  95      


Cys Glu Asp Gly Lys Ser Ser Thr Phe Glu Thr Tyr Lys Leu Arg Ala 
            100                 105                 110         


Lys Ala Ala Val Glu Glu Val Ser Leu His Glu Phe Ala Arg Val Leu 
        115                 120                 125             


Phe Met Leu Asn Lys Lys Arg Gly Tyr Lys Ser Asn Arg Lys Ala Asn 
    130                 135                 140                 


Asp Lys Glu Glu Gly Lys Leu Phe Asp Gly Met Thr Ile Ala Lys Lys 
145                 150                 155                 160 


Leu Tyr Glu Glu His Leu Thr Pro Ala Glu Tyr Ser Leu Gln Leu Leu 
                165                 170                 175     


Asn Thr Gly Arg Lys Phe Thr Pro Glu Tyr Tyr Arg Ser Asp Leu Ile 
            180                 185                 190         


Glu Glu Phe Glu Lys Ile Trp Asn Glu Gln Gln Lys Tyr Tyr Pro Glu 
        195                 200                 205             


Ile Leu Thr Asp Glu Phe Lys Gln Gln Leu Glu Gly Lys Ala Lys Ser 
    210                 215                 220                 


Asn Thr Ser Lys Leu Phe Leu Gly Lys Tyr Gly Ile Tyr Ser Ala Asp 
225                 230                 235                 240 


Thr Lys Gly Leu Asp Arg Arg Leu Gln Pro Leu Lys Trp Arg Val Glu 
                245                 250                 255     


Ala Met Lys Gln Gln Val Asp Lys Asp Val Leu Ala Phe Val Ile Ser 
            260                 265                 270         


Asp Leu Lys Gly Gln Ile Ala Asn Thr Ser Gly Leu Leu Gly Ala Ile 
        275                 280                 285             


Ser Asp Arg Ser Lys Glu Leu Tyr Phe Ser Lys Gln Thr Ile Gly Gln 
    290                 295                 300                 


Tyr Leu Trp Ala Ser Leu Gln Glu Asn Pro His Ile Ser Ile Lys Asn 
305                 310                 315                 320 


Gln Pro Phe Tyr Arg Gln Asp Tyr Leu Asp Glu Phe Glu Lys Ile Trp 
                325                 330                 335     


Glu Thr Gln Ala Thr Tyr His Lys Glu Leu Thr Ser Glu Leu Lys Gln 
            340                 345                 350         


Glu Ile Arg Asp Ile Ile Ile Phe Tyr Gln Arg Pro Leu Lys Ser Lys 
        355                 360                 365             


Lys Asn Leu Ile Ala Val Cys Glu Leu Glu Gln Arg Lys Val Lys Val 
    370                 375                 380                 


Thr Val Asp Gly Lys Glu Lys Glu Ile Thr Ile Gly Pro Lys Ile Ala 
385                 390                 395                 400 


Pro Lys Ser Ser Pro Met Phe Gln Glu Phe Arg Ile Trp Gln Asn Leu 
                405                 410                 415     


Asn Asn Ile Leu Leu Leu Asp His Glu Thr Asn Ser Lys Arg Pro Leu 
            420                 425                 430         


Tyr Glu Glu Glu Arg Asn Leu Leu Tyr Glu Glu Leu Ser Val Lys Glu 
        435                 440                 445             


Lys Leu Ser Lys Thr Glu Ala Leu Lys Val Leu Gly Lys Lys Ser Lys 
    450                 455                 460                 


Gln Trp Asp Leu Asn Tyr Lys Glu Leu Glu Gly Asn Arg Thr Gln Ala 
465                 470                 475                 480 


Val Leu Tyr Asp Cys Tyr Asn Arg Ile Ile Val Met Ser Gly His Glu 
                485                 490                 495     


Glu Cys Asn Phe Lys Lys Leu Lys Ala Ser Asp Ile Arg His Tyr Val 
            500                 505                 510         


Lys Met Ile Phe Lys Asn Leu Ala Phe Asn Thr Asp Ile Leu Cys Phe 
        515                 520                 525             


Asp Ser Ser Leu Lys Gly His Glu Leu Glu Arg Gln Pro Met Cys Gln 
    530                 535                 540                 


Leu Trp His Leu Leu Tyr Ser Tyr Glu Gly Asp Asn Ser Arg Thr Gly 
545                 550                 555                 560 


Asn Asp Ala Leu Leu Arg Lys Leu Glu Thr Ser Phe Gly Phe Pro Lys 
                565                 570                 575     


Glu Tyr Ala Ala Val Leu Ala Asp Val Ile Phe Glu Asp Ser Tyr Gly 
            580                 585                 590         


Asn Leu Ser Val Lys Ala Met Arg Asn Ile Leu Pro His Leu Gln Ala 
        595                 600                 605             


Gly Lys Asp Tyr Ser Gln Ala Cys Glu Glu Ala Gly Tyr Lys His Ser 
    610                 615                 620                 


Arg Arg Ser Leu Thr Lys Glu Glu Leu Asn Gln Lys Val Tyr Lys Glu 
625                 630                 635                 640 


Lys Leu Glu Leu Leu Pro Lys Asn Ser Leu His Asn Pro Val Val Glu 
                645                 650                 655     


Lys Ile Leu Asn Gln Met Val Asn Val Ile Asn Ala Val Ile Glu Glu 
            660                 665                 670         


Tyr Gly Lys Pro Asp Glu Ile Arg Ile Glu Leu Ala Arg Asp Leu Lys 
        675                 680                 685             


Ile Gly Ala Ala Glu Arg Glu Asn Met Thr Arg Ser Ile Asn Gln Gly 
    690                 695                 700                 


Asn Ala Glu Asn Lys Arg Ile Arg Glu Ile Leu Glu Lys Glu Phe Ala 
705                 710                 715                 720 


Leu Ser Tyr Leu Ser Arg Asn Asp Ile Ile Lys Tyr Lys Leu Tyr Glu 
                725                 730                 735     


Glu Leu Lys Ser Asn Gly Phe Lys Thr Leu Tyr Ser Asp Thr Tyr Ile 
            740                 745                 750         


Ser Lys Asp Lys Leu Phe Ser Lys Asp Phe Asp Ile Glu His Ile Ile 
        755                 760                 765             


Pro Lys Ala Arg Leu Phe Asp Asp Ser Leu Ser Asn Lys Thr Ile Glu 
    770                 775                 780                 


Ala Arg Asp Val Asn Ile Ala Lys Ser Asn Lys Thr Ala Phe Asp Phe 
785                 790                 795                 800 


Ile Leu Glu Arg Tyr Gly Glu Gln Gly Val Lys Thr Tyr Lys Thr Lys 
                805                 810                 815     


Leu Leu Arg Leu Leu Glu Asp Gly Ala Ile Ser Asn Lys Lys Tyr Asn 
            820                 825                 830         


Asn Leu Leu Lys Thr Glu Ala Asp Ile Pro Ser Gly Phe Ile Asp Arg 
        835                 840                 845             


Asp Leu Arg Asn Thr Gln Tyr Ile Ala Lys Lys Ala Tyr Glu Ile Leu 
    850                 855                 860                 


Ser Glu Leu Val Lys Ile Val Thr Pro Thr Thr Gly Ser Val Thr Asn 
865                 870                 875                 880 


Arg Leu Arg Glu Asp Trp Gln Leu Val Asp Val Met Lys Glu Leu Asn 
                885                 890                 895     


Phe Glu Lys Tyr Gln Lys Leu Gly Leu Ala Asp Val Ile Glu Asp Arg 
            900                 905                 910         


Asp Gly Arg Lys Val Lys Arg Ile Lys Asp Trp Thr Lys Arg Asn Asp 
        915                 920                 925             


His Arg His His Ala Met Asp Ala Leu Thr Ile Ala Phe Thr Lys Pro 
    930                 935                 940                 


Ser Tyr Ile Gln Tyr Leu Asn Asn Leu Asn Ala Arg Ser Asp Lys Ser 
945                 950                 955                 960 


Ser Ser Ile Tyr Gly Ile Glu Val Lys Glu Leu His Arg Glu Glu Gly 
                965                 970                 975     


Lys Phe Arg Phe Asn Ala Pro Leu Pro Ile Asn Glu Phe Arg Ala Glu 
            980                 985                 990         


Ala Lys Arg His Leu Lys Ser Val  Leu Val Ser Ile Lys  Ala Lys Lys 
        995                 1000                 1005             


Lys Val  Met Thr Gln Asn Val  Asn Lys Ile Lys Thr  Lys His Gly 
    1010                 1015                 1020             


Ile Ile  Lys Lys Val Gln Leu  Thr Pro Arg Gly Glu  Leu His Asn 
    1025                 1030                 1035             


Ala Thr  Tyr Tyr Gly Thr Lys  Lys Arg Pro Leu Val  Arg Met Val 
    1040                 1045                 1050             


Lys Val  Gly Ala Ala Leu Asp  Glu Ala Thr Ile Lys  Arg Val Cys 
    1055                 1060                 1065             


Ser Pro  Ala Ile Arg Ala Ala  Leu Leu Lys Arg Leu  Asn Ala Tyr 
    1070                 1075                 1080             


Asn Gly  Asp Ala Lys Glu Ala  Phe Thr Gly Arg Asn  Ser Ile Asp 
    1085                 1090                 1095             


Lys Asn  Pro Ile Tyr Leu Asp  Ile Glu Gln Thr Lys  Leu Val Pro 
    1100                 1105                 1110             


Val Leu  Val Lys Thr Ile Glu  Trp Gly Met Tyr His  Pro Ile Arg 
    1115                 1120                 1125             


Lys Arg  Ile Thr Pro Asp Leu  Lys Ile Asp Lys Val  Ile Asp Lys 
    1130                 1135                 1140             


Gly Ile  Arg Glu Lys Leu Lys  Ala Arg Leu Ala Glu  Phe Asn Gly 
    1145                 1150                 1155             


Asp Ala  Gln Lys Ala Phe Ser  Asn Leu Asp Glu Asn  Pro Ile Tyr 
    1160                 1165                 1170             


Met Asp  Glu Ala Lys Arg Ile  Thr Leu Lys Arg Val  Ser Ile Glu 
    1175                 1180                 1185             


Gly Val  Leu Ser Ala Ile Pro  Leu His Thr Leu Lys  Asp Lys Ala 
    1190                 1195                 1200             


Gly Lys  Pro Val Ile Gly Ser  Asp Gly Lys Pro Val  Phe Gly Asp 
    1205                 1210                 1215             


Tyr Val  Gln Thr Ser Asn Asn  His His Ile Ala Phe  Tyr Ile Asp 
    1220                 1225                 1230             


Asp Lys  Gly Asn Leu Gln Asp  Asn Pro Val Ser Phe  Phe Glu Ala 
    1235                 1240                 1245             


Ala Glu  Arg Lys Ser Gln Gly  Val Pro Val Ile Asp  Arg Arg Tyr 
    1250                 1255                 1260             


Asn Cys  Asp Lys Gly Trp His  Phe Val Phe Thr Met  Lys Gln Asn 
    1265                 1270                 1275             


Glu Tyr  Phe Val Phe Pro Asn  Glu Ala Thr Gly Phe  Ile Pro Ser 
    1280                 1285                 1290             


Glu Val  Asp Leu Leu Asp Glu  Ala Asn Tyr Cys Ile  Ile Ser Pro 
    1295                 1300                 1305             


Asn Leu  Tyr Arg Val Gln Lys  Leu Ser Lys Ala Ser  Gly Arg Asp 
    1310                 1315                 1320             


Tyr Trp  Phe Arg His His Leu  Glu Thr Met Leu Asn  Asp Asp Leu 
    1325                 1330                 1335             


Arg Leu  Lys Asn Ser Thr Phe  Lys Arg Ile Gln Ser  Leu Lys Gly 
    1340                 1345                 1350             


Leu Glu  Asp Ile Val Lys Val  Arg Ile Asn Ser Ile  Gly Lys Ile 
    1355                 1360                 1365             


Val Ala  Val Gly Lys Tyr Asp  
    1370                 1375 


<210> 401
<211> 1216
<212> PRT
<213> Prevotella stercorea


<220>
<223> Prevotella stercorea DSM 18206

<400> 401
Met Thr Lys Ile Leu Gly Ile Asp Thr Gly Thr Asn Ser Leu Gly Trp 
1               5                   10                  15      


Ala Ile Val Asp Lys Thr Ala Asp Asn Tyr Asn Leu Leu Asp Lys Gly 
            20                  25                  30          


Val Asn Ile Phe Gln Glu Gly Val Lys Ile Glu Lys Gly Ile Glu Ser 
        35                  40                  45              


Ser Lys Ala Ala Glu Arg Thr Glu His Arg Ala Thr Arg Val Arg Tyr 
    50                  55                  60                  


Tyr Arg Ile Lys Leu Arg Lys Ile Arg Leu Leu Arg Ile Leu Ser Asp 
65                  70                  75                  80  


Asn His Leu Cys Pro Pro Leu Ser Gln Glu Glu Leu Ser Thr Trp Arg 
                85                  90                  95      


Leu Lys Lys Val Tyr Pro Lys Asn Glu Leu Phe Met Gln Trp Gln Arg 
            100                 105                 110         


Thr Asp Asp Asp Thr Glu Lys Thr Pro Tyr Ala Tyr Arg His Lys Cys 
        115                 120                 125             


Ile His Glu Lys Leu Asp Leu Ser Asp Val Thr Asp Arg Tyr Ile Leu 
    130                 135                 140                 


Gly Arg Ala Phe Tyr His Ile Ile Gln Arg Arg Gly Phe Leu Ser Asn 
145                 150                 155                 160 


Arg Lys Glu Gln Gly Gly Glu Asp Ser Gly Lys Val Lys Glu Gly Ile 
                165                 170                 175     


Ser Thr Leu Thr His Glu Met Asn Glu Ala Gly Tyr Glu Tyr Leu Gly 
            180                 185                 190         


Asp Tyr Phe Tyr Ala Leu Tyr Asn Lys Gly Glu Lys Ile Arg Lys His 
        195                 200                 205             


Tyr Thr Ala Arg Asn Glu His Phe Leu Ser Glu Phe Lys Ala Ile Cys 
    210                 215                 220                 


Glu Lys Gln Asp Leu Glu Lys Glu Leu Gly Ser Glu Val Val Arg Asn 
225                 230                 235                 240 


Ile Glu Lys Ala Ile Phe Asp Gln Arg Pro Leu Lys Ser Gln Lys Gly 
                245                 250                 255     


Gln Val Gly Lys Cys Val Phe Glu Lys Asn Lys Thr Lys Cys Pro Ser 
            260                 265                 270         


Ser His Pro Met Tyr Glu Glu Phe Arg Met Leu Thr Phe Ile Asn Asn 
        275                 280                 285             


Ile Lys Ile Lys Thr Pro Asn Asp Asp Val Leu Arg Pro Leu Asn Thr 
    290                 295                 300                 


Gly Glu Arg Glu Lys Ile Met Pro Leu Phe Phe Arg Lys Ser Lys Lys 
305                 310                 315                 320 


Gln Phe Asp Phe Glu Asp Ile Thr Lys Lys Leu Ala Pro Lys Lys Met 
                325                 330                 335     


Tyr Gly Phe Tyr Lys Lys Glu Glu Asp Ala Glu Met Pro Phe Leu Phe 
            340                 345                 350         


Asn Tyr Pro Met Asp Thr Ser Val Ser Gly Cys Pro Val Thr Ala Ala 
        355                 360                 365             


Leu Lys Asp Val Phe Gly Asp Asp Trp Ile Thr Ala Ile Cys Glu Thr 
    370                 375                 380                 


Tyr Thr Leu Gly Glu Gly Lys Ser Arg Phe Asp Ile Val Asn Asp Ile 
385                 390                 395                 400 


Trp His Ala Leu Tyr Phe Tyr Ser Asp Lys Asp Lys Leu Ala Glu Phe 
                405                 410                 415     


Ala Ile Asn Arg Leu Gln Leu Ser Glu Asp Glu Ala Lys Ile Phe Ser 
            420                 425                 430         


Glu Ile Ser Leu Pro Ala Asp Tyr Ala Ser Leu Ser Leu Lys Ala Ile 
        435                 440                 445             


Cys Lys Ile Leu Pro Tyr Leu Arg Arg Gly Leu Ile Tyr Ser His Ala 
    450                 455                 460                 


Val Phe Leu Gly Asn Leu Cys Glu Val Met Pro Lys Tyr Glu Trp Ser 
465                 470                 475                 480 


Ile Lys Glu Met Arg Glu Thr Ile Ile Asp Asn Ile Ile Met Glu Met 
                485                 490                 495     


Asp Lys Cys Asp Thr Lys Asp Lys Arg Thr Phe Glu Val Cys Ile Lys 
            500                 505                 510         


Asp Tyr Leu Lys Gly Gln Tyr Asn Val Ser Asp Asn Ser Leu Lys Lys 
        515                 520                 525             


Leu Tyr His Pro Ser Met Ile Glu Thr Tyr Pro Arg Val Gln Tyr Thr 
    530                 535                 540                 


Asn Glu His Gly Val Tyr Gln Leu Gly Ser Pro Arg Ile Asp Ser Val 
545                 550                 555                 560 


Arg Asn Pro Met Ala Met Arg Ser Met Phe Arg Leu Arg Lys Leu Val 
                565                 570                 575     


Asn Arg Leu Leu Val Glu Gly Lys Ile Asp Gln Asn Thr Glu Val His 
            580                 585                 590         


Ile Glu Phe Ala Arg Glu Leu Asn Asp Ala Asn Lys Arg Asn Ala Ile 
        595                 600                 605             


Ala Leu Phe Val Lys Glu Asn Gln Ser Ala Asn Asp Glu Ala Arg Lys 
    610                 615                 620                 


Gln Ile Ile Thr Leu Phe Lys Lys Glu Thr Gly Thr Asp Ile Glu Pro 
625                 630                 635                 640 


Thr Asp Lys Asp Ile Leu Lys Tyr Val Leu Trp Glu Glu Gln Asn His 
                645                 650                 655     


Ile Cys Leu Tyr Thr Gly Lys Gln Ile Arg Ile Ser Asp Phe Ile Gly 
            660                 665                 670         


Ala Asn Pro Lys Phe Asp Ile Glu His Thr Ile Pro Arg Ser Val Gly 
        675                 680                 685             


Gly Asp Ser Thr Lys Met Asn Leu Thr Leu Cys Asp Ser Arg Phe Asn 
    690                 695                 700                 


Arg Glu Val Lys Lys Thr Lys Leu Pro Val Glu Leu Pro Asn His Asp 
705                 710                 715                 720 


Glu Ile Met Glu Arg Ile Lys Glu Trp Lys Lys Asn Tyr Glu Leu Leu 
                725                 730                 735     


Asp Ile Gln Ile Arg Lys Asn Lys Lys Leu Ser Lys Gly Ala Thr Thr 
            740                 745                 750         


Lys Glu Gln Lys Asp Thr Ile Ile Arg Lys Arg His Leu Leu Glu Leu 
        755                 760                 765             


Arg Arg Asp Tyr Trp Arg Gly Lys Tyr Glu Arg Phe Thr Met Glu Ser 
    770                 775                 780                 


Val Pro Glu Gly Phe Ser Arg Arg Gln Gly Thr Asp Ile Ser Val Ile 
785                 790                 795                 800 


Ser Lys Tyr Ala Arg Leu Tyr Leu Lys Ser Leu Phe Asn Arg Val Tyr 
                805                 810                 815     


Thr Val Lys Gly Ile Ala Thr Ser Asp Phe Arg Lys Ile Trp Gly Ile 
            820                 825                 830         


Gln Asp Ile Tyr Ser Lys Lys Glu Arg Ile Asn His Val His His Cys 
        835                 840                 845             


Ile Asp Ala Ile Val Ile Ala Cys Ile Gly Leu Asp Glu Tyr Asn Lys 
    850                 855                 860                 


Leu Gly Ala Tyr Tyr His Asp Glu Glu Asn Asn Lys Trp Tyr Gly Met 
865                 870                 875                 880 


Ser Lys Ala Ser Phe Lys Lys Pro Trp Ala Thr Phe Val Glu Asp Ile 
                885                 890                 895     


Lys Lys Ile Gln Asp Glu Ile Leu Val Tyr His Tyr Thr Pro Asp Asn 
            900                 905                 910         


Met Pro Lys Gln Gly Arg Arg Arg Ile Lys Ile Asp Gly Lys Lys Ile 
        915                 920                 925             


Leu Cys Lys Gly Asp Ala Ala Arg Gly Ser Leu His Asn Asp Thr Tyr 
    930                 935                 940                 


Tyr Gly Ala Ile Glu Asn Asp Gly Ala Val Lys Tyr Val Lys Arg Ile 
945                 950                 955                 960 


Asp Leu Ala Ser Leu Glu Glu Lys Asp Val Lys Asn Ile Val Asp Asp 
                965                 970                 975     


Thr Val Arg Ser Ile Ile Glu Ala Ala Ile Lys Glu Lys Gly Phe Lys 
            980                 985                 990         


Asp Ala Met Ala Ser Thr Ile Trp  Met Asn Glu Glu Lys  Arg Val Pro 
        995                 1000                 1005             


Ile Lys  Lys Val Arg Cys Phe  Thr Pro Ser Ile Thr  Lys Pro Leu 
    1010                 1015                 1020             


Asn Ile  Arg Lys Gln Arg Asp  Val Ser Ile Lys Glu  Tyr Lys Gln 
    1025                 1030                 1035             


Gln Tyr  His Val Ala Asn Asp  Ser Asn Tyr Leu Leu  Ala Leu Tyr 
    1040                 1045                 1050             


Ile Gly  Thr Asp Asn Lys Gly  Lys Glu Lys Arg Glu  Phe Glu Ile 
    1055                 1060                 1065             


Val Asn  Ile Leu Gln Ala Ala  Gln Tyr Tyr Arg Thr  Ser Asn Asp 
    1070                 1075                 1080             


Lys Glu  Val Val Asp Arg His  Ile Val Pro Ile Lys  Ser Glu His 
    1085                 1090                 1095             


Asp Tyr  Pro Phe Ala Tyr Thr  Leu Lys Ile Gly Thr  Met Val Leu 
    1100                 1105                 1110             


Leu Tyr  Glu Lys Ser Pro Asn  Glu Val Trp Asp Ala  Thr Ile Lys 
    1115                 1120                 1125             


Glu Arg  Asn Arg Arg Leu Tyr  Lys Val Thr Gly Leu  Ser Thr Met 
    1130                 1135                 1140             


Arg Met  Lys Gly Arg Asn Gly  Glu Tyr Ala Tyr Ala  Thr Val Lys 
    1145                 1150                 1155             


Leu Ile  His Asn Glu Glu Ala  Arg Pro Ser Lys Asp  Ile Lys Ala 
    1160                 1165                 1170             


Lys Asn  Gly Glu Tyr Glu Gln  Gly Glu Glu Phe Arg  Pro Ala Ile 
    1175                 1180                 1185             


Ile Met  Leu His Thr Gln Leu  Asn Ala Leu Val Gln  Gly Tyr Asp 
    1190                 1195                 1200             


Phe Glu  Ile Asn Glu Leu Gly  Glu Ile Arg Arg Leu  Arg 
    1205                 1210                 1215     


<210> 402
<211> 1234
<212> PRT
<213> Prevotella tannerae


<220>
<223> Prevotella tannerae ATCC 51259

<400> 402
Met Pro Asn Phe Trp Ser Ile Phe Thr Glu Asn Leu Gln Thr Tyr Leu 
1               5                   10                  15      


Met Lys Thr Arg Ile Leu Gly Leu Asp Thr Gly Thr Asn Ser Leu Gly 
            20                  25                  30          


Trp Ala Val Val Asp Arg Asp Glu Asn Asn Gln Tyr Thr Pro Ile Cys 
        35                  40                  45              


Arg Gly Asp Leu Ile Phe Thr Glu Gly Val Lys Gln Glu Lys Gly Ile 
    50                  55                  60                  


Glu Phe Ser Leu Ala Ala Glu Arg Thr Ser Tyr Arg Ala Ser Arg Arg 
65                  70                  75                  80  


His Tyr Phe Arg Arg Arg Leu Arg Lys Val Glu Val Leu Lys Val Leu 
                85                  90                  95      


Val Lys His Lys Leu Cys Pro Pro Leu Ser Asp Glu Ala Leu Asn Arg 
            100                 105                 110         


Trp His Thr Lys Lys Glu Tyr Pro Leu Asp Glu Asp Phe Ile Leu Trp 
        115                 120                 125             


Gln Arg Thr Asn Glu Ala Asp Asn Lys Asn Pro Tyr His Asp Arg His 
    130                 135                 140                 


Ile Cys Leu His Arg Lys Leu Asn Leu Lys Asp Ser Gln Thr Asp Arg 
145                 150                 155                 160 


Tyr Thr Leu Gly Arg Ala Leu Tyr His Leu Thr Gln Arg Arg Gly Phe 
                165                 170                 175     


Leu Ser Asn Arg Leu Asp Gln Asn Glu Glu Ala Glu Glu Thr Gly Lys 
            180                 185                 190         


Val Lys Ser Ala Ile Ser Glu Leu Ser Lys Glu Met Lys Glu Ala Gly 
        195                 200                 205             


Cys Glu Phe Leu Gly Asp Tyr Phe Tyr Leu Leu Tyr Arg Thr Glu Gly 
    210                 215                 220                 


Asn Arg Val Arg Ile Arg Ser Arg Tyr Thr Asp Arg Glu Lys His Tyr 
225                 230                 235                 240 


Leu Gln Glu Phe Lys Glu Ile Cys Arg Val Gln Glu Leu Asp Glu Asp 
                245                 250                 255     


Leu Ala Lys Ala Leu Glu Lys Thr Ile Phe Phe Gln Arg Pro Leu Lys 
            260                 265                 270         


Ser Gln Arg Gln Gly Val Gly Lys Cys Thr Met Glu Lys Gly His Ser 
        275                 280                 285             


Arg Cys Ala Val Ser His Pro Leu Tyr Glu Glu Tyr Arg Leu Leu Cys 
    290                 295                 300                 


Tyr Leu Asn Asn Ile Arg Ile Lys Thr Pro Ser Asp Asp Arg Leu Arg 
305                 310                 315                 320 


Pro Leu Asn Ala Glu Glu Arg Glu Lys Ile Thr Pro Leu Phe Tyr Lys 
                325                 330                 335     


Glu Lys Asn Phe Asp Phe Glu Lys Ile Ala Lys Lys Leu Ala Gly Lys 
            340                 345                 350         


Thr Pro Phe Gly Trp Ile Arg Asp Ala Glu Asp Trp Pro Tyr Gln Phe 
        355                 360                 365             


Asn Tyr Arg Met Thr Gln Glu Ala Pro Ala Cys Pro Thr Thr Ala Gln 
    370                 375                 380                 


Leu Ile Lys Val Phe Gly Glu Asp Trp Lys Ala Ala Leu Ala Glu Thr 
385                 390                 395                 400 


Tyr Thr Met Ser Ala Lys Gln Asp Gly Thr Leu Lys Thr Glu Asp Glu 
                405                 410                 415     


Ile Cys Thr Asp Ile Trp Asn Val Leu Tyr Ser Phe Ser Ser Lys Glu 
            420                 425                 430         


Lys Leu Lys Glu Phe Gly Leu Lys Lys Leu Gln Leu Asp Glu Val Gln 
        435                 440                 445             


Ala Lys Ala Phe Ser Glu Ile Arg Leu Thr Arg Asp Phe Ala Ser Leu 
    450                 455                 460                 


Ser Leu Lys Ala Ile Arg Lys Ile Leu Phe Phe Leu Arg Thr Gly Glu 
465                 470                 475                 480 


Asp Tyr Ser Lys Ala Ile Phe Leu Ala Asn Ile Pro Thr Ile Val Gly 
                485                 490                 495     


Glu Glu Ile Trp Asn Asp Ile Glu Arg Arg Ser Arg Leu Leu Tyr Lys 
            500                 505                 510         


Val Asp Leu Ala Leu Arg Pro Gln Glu Glu Arg Asp Ala Glu Glu His 
        515                 520                 525             


Arg Thr Ile Ala Glu Arg Ile Lys Ala Ala Val Ala Ala Glu Val Pro 
    530                 535                 540                 


Asp Ala Pro Ile Asp Leu Leu Tyr His Pro Ser Met Ile Glu Ala Tyr 
545                 550                 555                 560 


Pro Asp Ala Lys Arg Asn Glu Arg Phe Asp Cys Tyr Gln Leu Gly Ser 
                565                 570                 575     


Pro Lys Thr Asn Ala Val Arg Asn Pro Met Ala Met Arg Ser Leu His 
            580                 585                 590         


Met Val Arg Lys Val Ile Asn His Leu Leu Arg Lys His Ile Ile Asp 
        595                 600                 605             


Glu Lys Thr Glu Ile His Ile Glu Tyr Ala Arg Glu Leu Asn Asp Ala 
    610                 615                 620                 


Asn Lys Arg Gln Ala Ile Ala Asp Trp Gln Arg Glu Leu Ser Lys Arg 
625                 630                 635                 640 


His Thr Ala Tyr Ala Gln Asn Ile Arg Gln Leu Tyr Lys Ala Glu Thr 
                645                 650                 655     


Gly Leu Val Ile Glu Pro Thr Lys Ala Asp Ile Leu Lys Tyr Gln Leu 
            660                 665                 670         


Trp Glu Glu Gln Gln His Val Cys Leu Tyr Thr Gly Lys Lys Ile Gly 
        675                 680                 685             


Ile Ala Asp Phe Leu Gly Ala Asn Pro Lys Phe Asp Ile Glu His Thr 
    690                 695                 700                 


Ile Pro Arg Ser Arg Gly Gly Asp Ser Thr Gln Glu Asn Leu Thr Leu 
705                 710                 715                 720 


Cys Glu Ser Lys Phe Asn Arg Asp Ile Lys Arg Asp Lys Leu Pro Thr 
                725                 730                 735     


Glu Leu Ala Asn Tyr Glu Glu Ile Leu Ala Arg Ile Glu His Trp Lys 
            740                 745                 750         


Lys Gln Cys Tyr Ala Leu Lys Leu Lys Arg Asp Gly Ile Arg Thr His 
        755                 760                 765             


Ser Gly Leu Glu Lys Ser Ile Lys Asp Ser Arg Ile Arg Arg Arg His 
    770                 775                 780                 


Leu Val Gly Leu Glu Tyr Gly Tyr Leu Lys Gly Lys Tyr Asp Arg Phe 
785                 790                 795                 800 


Thr Met Lys Glu Val Pro Glu Gly Phe Ser Arg Arg Gln Gly Ala Gly 
                805                 810                 815     


Ile Gly Leu Ile Ser Lys Tyr Ala Gly Leu Phe Leu Lys Ser Leu Phe 
            820                 825                 830         


Lys Asp Pro Lys Asn Pro Asn Arg Ser Asn Val Tyr Val Val Lys Gly 
        835                 840                 845             


Ala Ile Thr Ala Glu Phe Arg Lys Leu Trp Gly Leu Gln Gln Ala Asp 
    850                 855                 860                 


Glu Ala Lys Ser Arg Glu Asn His Thr His His Cys Ile Asp Ala Tyr 
865                 870                 875                 880 


Thr Ile Ala Cys Ile Gly Pro Cys Glu Tyr Ala Ala Leu Ala Ala Tyr 
                885                 890                 895     


Tyr Arg Ser Asp Glu Glu Phe Lys Tyr Gly Arg Arg Arg Glu Lys Pro 
            900                 905                 910         


Gln Phe Glu Lys Pro Trp Pro Thr Phe Thr Glu Asp Leu Leu Lys Leu 
        915                 920                 925             


Gln Glu Glu Leu Leu Ile Val His Gln Thr Thr Asp Lys Leu Gly Lys 
    930                 935                 940                 


Arg Asp Arg Arg Lys Val Lys Thr Pro Arg Gly Lys Phe Leu Thr Gly 
945                 950                 955                 960 


Gly Asp Ser Ala Arg Gly Arg Leu His Gln Glu Thr Tyr Tyr Gly Ala 
                965                 970                 975     


Ile Asn Tyr Asp Gly Asn Ile Lys Tyr Val Val Arg Lys Pro Leu Asp 
            980                 985                 990         


Ser Leu Thr Glu Lys Asp Leu Asp  Lys Ile Val Asp Glu  Thr Val Met 
        995                 1000                 1005             


Gly Ile  Val Lys Gly Ala Val  Glu Ala Lys Gly Ser  Leu Lys Glu 
    1010                 1015                 1020             


Ala Leu  Ala Asp Gly Ile Tyr  Met Asn Lys Glu Lys  Gly Ile Leu 
    1025                 1030                 1035             


Ile Lys  Arg Val Arg Ile Phe  Ser Asp Val Ser Glu  Pro Ile Asn 
    1040                 1045                 1050             


Leu Lys  Gln Leu Arg Asp Val  Ser Thr Lys Glu Tyr  Lys Arg His 
    1055                 1060                 1065             


Ile His  Leu Arg Lys Asp Glu  Asn Tyr Leu Phe Ala  Ile Tyr Glu 
    1070                 1075                 1080             


Gly Ile  Asp Lys Lys Lys Asn  Lys Lys Gln Thr Glu  Thr Ala Thr 
    1085                 1090                 1095             


Val Asp  Tyr Leu Asp Ala Ala  Lys Phe Tyr Lys Asp  Ser Lys Arg 
    1100                 1105                 1110             


Arg Asp  Lys Ala Asn Ser Leu  Val Gly Asp Tyr Ser  Lys Lys Asn 
    1115                 1120                 1125             


Lys Leu  Pro Leu Lys Cys Ile  Leu Lys Lys Arg Gln  Met Val Leu 
    1130                 1135                 1140             


Phe Tyr  Glu His Ser Pro Glu  Glu Ile Arg Phe Lys  Asp Lys Lys 
    1145                 1150                 1155             


Asp Leu  Ser Arg Arg Leu Tyr  Ile Val Thr Ser Ile  Ala Lys Asp 
    1160                 1165                 1170             


Gly Arg  Val Lys Phe Leu His  His Gln Ala Ala Thr  Ala Thr Gly 
    1175                 1180                 1185             


Ile Gln  Ser Ser Pro Ser Pro  Phe Thr Asn Asp Gly  Glu His Gln 
    1190                 1195                 1200             


Pro Tyr  Tyr Arg Leu Ser Ala  Ser Asn Ile Lys Val  Leu Val Ala 
    1205                 1210                 1215             


Gly Ile  Asp Phe Asp Ile Asn  Ile Leu Gly Glu Ile  Thr Pro Lys 
    1220                 1225                 1230             


Leu 
    


<210> 403
<211> 1487
<212> PRT
<213> Prevotella timonensis


<220>
<223> Prevotella timonensis CRIS 5C-B1

<400> 403
Met Lys Asn Ile Leu Gly Leu Asp Leu Gly Ser Asn Ser Val Gly Trp 
1               5                   10                  15      


Ala Leu Val Lys Val Glu Glu Asn Gly Asn Pro Ile Gly Ser Ile Lys 
            20                  25                  30          


Met Gly Ser Arg Ile Ile Pro Met Ser Gln Asp Ile Leu Gly Ser Phe 
        35                  40                  45              


Glu Lys Gly Asp Thr Val Ser Gln Thr Ala Gln Arg Thr Leu Tyr Arg 
    50                  55                  60                  


Gly Lys Arg Arg Leu Ile Glu Arg His Val Leu Arg Arg Glu Arg Leu 
65                  70                  75                  80  


Cys Arg Val Leu His Ile Met Asn Phe Leu Pro Ala His Phe Asp Arg 
                85                  90                  95      


Leu Leu Gly Trp Asp Lys Thr Asp Asn Lys Thr Tyr Gly Lys Phe Ile 
            100                 105                 110         


Asp Asp Ser Glu Pro Lys Leu Ala Trp Arg Gln Asn Lys Asn Glu Met 
        115                 120                 125             


Gly Lys Met Glu Phe Val Phe Met Asp Ser Phe His Glu Met Leu Ser 
    130                 135                 140                 


Asp Phe Ala Lys His Gln Pro Gln Leu Ile Ala Asn Gly Lys Lys Val 
145                 150                 155                 160 


Pro Leu Asp Trp Thr Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Thr Gln 
                165                 170                 175     


Leu Ile Ser Lys Glu Glu Leu Ala Trp Ile Leu Leu Asn Phe Asn Lys 
            180                 185                 190         


Lys Arg Gly Tyr Tyr Gln Leu Arg Gly Glu Glu Glu Glu Glu Gln Pro 
        195                 200                 205             


Thr Lys Lys Glu Glu Tyr Lys Val Leu Lys Val Ile Ser Val Asp Ala 
    210                 215                 220                 


Asp Glu Gly Gln Lys Gly Asn Gly Ile Trp Tyr Asn Ile His Leu Glu 
225                 230                 235                 240 


Asp Gly Gly Ile Tyr Lys Lys Lys Ser Asp Ile Pro Leu Tyr Asp Trp 
                245                 250                 255     


Val Gly Lys Thr Leu Gln Leu Ile Val Val Thr Thr Tyr Glu Lys Asp 
            260                 265                 270         


Gly Lys Thr Pro Lys Ile Phe Asp Ser Gly Lys Gln Asn Pro Ser Tyr 
        275                 280                 285             


Arg Leu Pro Lys Glu Asp Asp Trp Gly Leu Val Lys Lys Arg Thr Glu 
    290                 295                 300                 


Ser Gln Leu Gln Ser Ser Gly Lys Thr Val Gly Ala Phe Ile Tyr Asp 
305                 310                 315                 320 


Asn Ile Leu Ser Lys Pro Asp Asp Lys Ile Arg Gly Asn Leu Val Arg 
                325                 330                 335     


Thr Ile Glu Arg Lys Tyr Tyr Lys Lys Glu Leu Ile Glu Ile Leu Gln 
            340                 345                 350         


Gln Gln Ala Lys Tyr His Asp Glu Leu His Asn Gln Asn Leu Leu Glu 
        355                 360                 365             


Ser Cys Ala Lys Glu Leu Tyr Ala His Asn Asp Val His Tyr Asn Glu 
    370                 375                 380                 


Val Ile Lys Ser Asn Met Ile Asn Leu Leu Val Asn Asp Ile Ile Phe 
385                 390                 395                 400 


Tyr Gln Arg Pro Leu Lys Ser Lys Lys Ser Leu Ile Ala Asn Cys Lys 
                405                 410                 415     


Tyr Glu Ser Tyr Glu Tyr Val Asp Lys Glu Thr Gly Glu Ile Lys Glu 
            420                 425                 430         


Met Pro Ile Lys Cys Ile Ala Lys Ser Asn Pro Tyr Tyr Gln Glu Phe 
        435                 440                 445             


Arg Leu Trp Gln Phe Ile His Asn Leu Arg Leu Ser Asp Val Val Thr 
    450                 455                 460                 


Arg Glu Asp Val Thr Ala Gln Tyr Leu Ser Thr Pro Gln Asp Tyr Cys 
465                 470                 475                 480 


Asn Leu Phe Thr Tyr Leu Asn Asp Arg Lys Glu Ile Lys Gln Asp Ile 
                485                 490                 495     


Leu Leu Lys Asp Phe Phe Lys Ile Lys Lys Val Gln Ile Asp Lys Glu 
            500                 505                 510         


Lys Val Phe Pro Ile Glu Trp Asn Tyr Ile Lys Asp Ala Thr Lys Ser 
        515                 520                 525             


Tyr Pro Cys Asn Glu Thr Arg Tyr Glu Leu Leu Ser Ala Leu Lys Arg 
    530                 535                 540                 


Ala Gly Met Asp Lys Gln Trp Leu Asp Asp Thr Pro Asn Met Gln Tyr 
545                 550                 555                 560 


Arg Leu Trp His Leu Leu Tyr Ser Val Glu Glu Lys Glu Glu Ser Ala 
                565                 570                 575     


Lys Ala Leu Arg Lys Leu Tyr Asp Asp Asp Lys Phe Val Thr Ser Phe 
            580                 585                 590         


Leu Lys Ile Lys Pro Phe Asn Lys Cys Tyr Gly Ala Tyr Ser Glu Lys 
        595                 600                 605             


Ala Ile Lys Arg Leu Leu Thr Leu Met Arg Met Gly Lys Ala Trp Asn 
    610                 615                 620                 


Glu Gln Ala Ile Asp Ala Lys Thr Leu Lys Cys Ile Gln Gln Ile Ile 
625                 630                 635                 640 


Thr Asp Asn Val Asp Ser Lys Leu Lys Glu Lys Ile Asp Asp Ser Arg 
                645                 650                 655     


Tyr Val Leu His His Val Ser Asp Phe Gln Gly Leu Pro Thr Tyr Leu 
            660                 665                 670         


Ala Ser Tyr Val Ile Tyr Gly Arg His Ser Glu Val Thr Asp Ile Gln 
        675                 680                 685             


Cys Trp Asp Ser Pro Glu Asp Leu Leu Lys Phe Ile Arg Asp Phe Lys 
    690                 695                 700                 


Gln His Ser Leu Arg Asn Pro Ile Val Glu Gln Val Ile Leu Glu Thr 
705                 710                 715                 720 


Leu Arg Val Val Tyr Asp Ile Trp Lys Ala Glu Lys His Ile Asp Glu 
                725                 730                 735     


Ile His Val Glu Val Ala Arg Glu Met Lys Leu Thr Ala Gln Gln Arg 
            740                 745                 750         


Asn Glu Ala Asn Leu Arg Asn Leu Asn Asn Glu Ala Thr Asn Leu Arg 
        755                 760                 765             


Ile Lys Tyr Leu Leu Glu Glu Leu Lys Asn Asp Thr Phe Ile Lys Asp 
    770                 775                 780                 


Val Arg Pro Leu Ser Pro Ile His Gln Glu Lys Met Arg Ile Tyr Glu 
785                 790                 795                 800 


Gln Ala Val Leu Gly Asn Leu Asn Lys Gln Asp Lys Asp Tyr Asp Asp 
                805                 810                 815     


Ile Ile Lys Ile Ser Lys Lys Glu His Pro Thr Asn Ala Glu Leu Ile 
            820                 825                 830         


Arg Tyr Lys Leu Trp Leu Glu Gln Arg Tyr Cys Ser Pro Tyr Thr Gly 
        835                 840                 845             


Lys Ala Ile Ser Leu Ser Lys Leu Phe Thr Thr Ala Tyr Glu Ile Glu 
    850                 855                 860                 


His Ile Ile Pro Gln Ser Arg Tyr Phe Asp Asn Ser Phe Asn Asn Lys 
865                 870                 875                 880 


Val Ile Cys Glu Ala Glu Val Asn Lys Ala Lys Gly Asn Met Leu Gly 
                885                 890                 895     


Tyr Glu Phe Ile Lys Lys Gln Gly Gly Gln Lys Ile Tyr Cys Thr Gln 
            900                 905                 910         


Leu Gly Lys Ala Val Thr Ile Leu Lys Glu Glu Ala Tyr Lys Gln Phe 
        915                 920                 925             


Val Asn Glu His Tyr Ala His Asn Lys Arg Lys Arg Asp Asn Leu Leu 
    930                 935                 940                 


Ala Glu Asn Ile Pro Glu Ser Phe Ser Ser Arg Gln Leu Asn Asp Thr 
945                 950                 955                 960 


Arg Tyr Ile Thr Lys Thr Ile Met Ser Leu Leu Ser Asn Val Val Arg 
                965                 970                 975     


Gln Gln Ser Glu Glu Glu Ala Thr Ala Lys Asn Leu Leu Pro Ser Ser 
            980                 985                 990         


Gly Ser Val Thr Asp Arg Leu Lys  Asn Asp Trp Gly Leu  Lys Asp Val 
        995                 1000                 1005             


Trp Asn  Thr Ile Val Thr Pro  Arg Phe Glu Arg Leu  Asn Lys Leu 
    1010                 1015                 1020             


Ser Gly  Thr Asn Asp Phe Gly  Glu Met Lys Glu Glu  Asn Gly Asn 
    1025                 1030                 1035             


Arg Tyr  Phe Gln Thr Asn Val  Pro Leu Glu Tyr Glu  Lys Gly Phe 
    1040                 1045                 1050             


Lys Lys  Lys Arg Ile Asp His  Arg His His Ala Met  Asp Ala Leu 
    1055                 1060                 1065             


Val Ile  Ala Cys Thr Thr Arg  Asn Met Val Asn Tyr  Ile Ser Asn 
    1070                 1075                 1080             


Ala Asn  Ala Asn Ser Pro Lys  Gln Arg Glu Asp Leu  Arg Gln Leu 
    1085                 1090                 1095             


Leu Cys  Asp Lys Asn Arg Ile  Ile Asn Lys Pro Trp  Asp Thr Phe 
    1100                 1105                 1110             


Thr Gln  Asp Ala Leu Lys Ala  Leu Asn Asp Ile Val  Val Ser Phe 
    1115                 1120                 1125             


Lys Asn  Asn Val Arg Ile Ile  Asn Arg Ala Thr Asn  Arg Tyr Gln 
    1130                 1135                 1140             


Arg Tyr  Asp Lys Asn Gly Lys  Lys Ile Ile Phe Ser  Gln Lys Gly 
    1145                 1150                 1155             


Asp Asp  Met Trp Ala Ile Arg  Lys Ser Met His Lys  Glu Thr Val 
    1160                 1165                 1170             


Phe Gly  Arg Val Asn Leu Ile  Arg Lys Glu Val Leu  Pro Ile Ala 
    1175                 1180                 1185             


Lys Ala  Leu Asp Asn Ile Ser  Ala Ile Cys Asn Ala  Gln Leu Arg 
    1190                 1195                 1200             


Ala Tyr  Val Asn Asp Leu Val  Asp Lys His Phe Asn  Lys Lys Gln 
    1205                 1210                 1215             


Leu Val  Ala His Phe Lys Ser  Leu Asn Tyr Lys Trp  Asn Arg Gln 
    1220                 1225                 1230             


Asp Val  Ser Lys Val Glu Val  Trp Ile Ser Ser Asp  Asn Lys Thr 
    1235                 1240                 1245             


Pro Met  Val Ala Val Arg Lys  Pro Leu Asp Thr Ser  Phe Asp Lys 
    1250                 1255                 1260             


Lys Lys  Ile Ala Ser Ile Thr  Asp Thr Gly Ile Gln  Thr Ile Leu 
    1265                 1270                 1275             


Leu Asn  Tyr Leu Glu Ser Lys  Gly Gly Asp Ala Ser  Val Ala Phe 
    1280                 1285                 1290             


Ala Pro  Glu Gly Ile Gln Glu  Met Asn Ser Asn Ile  Glu Leu Tyr 
    1295                 1300                 1305             


Asn Asn  Gly Lys Ala His Lys  Pro Ile Lys Asn Val  Arg Leu Ser 
    1310                 1315                 1320             


Glu Pro  Leu Gly Ala Lys Tyr  Gln Val Gly Glu Arg  Gly Ala Lys 
    1325                 1330                 1335             


Thr Lys  Lys Tyr Val Glu Ala  Asp Lys Gly Thr Asn  Leu Phe Phe 
    1340                 1345                 1350             


Ala Ile  Tyr Glu Asp Glu Glu  Gly Lys Arg Tyr Tyr  Tyr Ser Val 
    1355                 1360                 1365             


Pro Leu  Arg Glu Ala Ile Glu  Arg Gln Lys Gln Lys  Leu Ser Pro 
    1370                 1375                 1380             


Val Pro  Glu Tyr Asn Glu Lys  Gly Val Ala Leu Lys  Phe Tyr Leu 
    1385                 1390                 1395             


Ser Pro  Asn Asp Leu Val Tyr  Val Pro Thr Glu Glu  Glu Arg Thr 
    1400                 1405                 1410             


Met Gly  Thr Cys His Ile Asp  Lys Ala Arg Ile Tyr  Lys Met Val 
    1415                 1420                 1425             


Ser Ser  Thr Gly Cys Ser Cys  Tyr Phe Val Pro Ser  Thr Phe Ala 
    1430                 1435                 1440             


Lys Val  Ile Val Asp Lys Val  Glu Leu Gln Ser Leu  Asn Lys Met 
    1445                 1450                 1455             


Glu Lys  Ala Ile Thr Asp Glu  Cys Ile Lys Glu Val  Cys Trp Lys 
    1460                 1465                 1470             


Leu Lys  Val Asp Arg Leu Gly  Asn Ile Ile Asn Val  Ile Lys 
    1475                 1480                 1485         


<210> 404
<211> 1218
<212> PRT
<213> Prevotella timonensis


<220>
<223> Prevotella timonensis CRIS 5C-B1

<400> 404
Met Asn Lys Arg Ile Leu Gly Leu Asp Thr Gly Thr Asn Ser Leu Gly 
1               5                   10                  15      


Trp Ala Val Val Asp Trp Asp Glu His Ala Gln Ser Tyr Glu Leu Ile 
            20                  25                  30          


Lys Tyr Gly Asp Val Ile Phe Gln Glu Gly Val Lys Ile Glu Lys Gly 
        35                  40                  45              


Ile Glu Ser Ser Lys Ala Ala Glu Arg Ser Gly Tyr Lys Ala Ile Arg 
    50                  55                  60                  


Lys Gln Tyr Phe Arg Arg Arg Leu Arg Lys Ile Gln Val Leu Lys Val 
65                  70                  75                  80  


Leu Val Lys Tyr His Leu Cys Pro Tyr Leu Ser Asp Asp Asp Leu Arg 
                85                  90                  95      


Gln Trp His Leu Gln Lys Gln Tyr Pro Lys Ser Asp Glu Leu Met Leu 
            100                 105                 110         


Trp Gln Arg Thr Ser Asp Glu Glu Gly Lys Asn Pro Tyr Tyr Asp Arg 
        115                 120                 125             


His Arg Cys Leu His Glu Lys Leu Asp Leu Thr Val Glu Ala Asp Arg 
    130                 135                 140                 


Tyr Thr Leu Gly Arg Ala Leu Tyr His Leu Thr Gln Arg Arg Gly Phe 
145                 150                 155                 160 


Leu Ser Asn Arg Leu Asp Thr Ser Ala Asp Asn Lys Glu Asp Gly Val 
                165                 170                 175     


Val Lys Ser Gly Ile Ser Gln Leu Ser Thr Glu Met Glu Glu Ala Gly 
            180                 185                 190         


Cys Glu Tyr Leu Gly Asp Tyr Phe Tyr Lys Leu Tyr Asp Ala Gln Gly 
        195                 200                 205             


Asn Lys Val Arg Ile Arg Gln Arg Tyr Thr Asp Arg Asn Lys His Tyr 
    210                 215                 220                 


Gln His Glu Phe Asp Ala Ile Cys Glu Lys Gln Glu Leu Ser Ser Glu 
225                 230                 235                 240 


Leu Ile Glu Asp Leu Gln Arg Ala Ile Phe Phe Gln Leu Pro Leu Lys 
                245                 250                 255     


Ser Gln Arg His Gly Val Gly Arg Cys Thr Phe Glu Arg Gly Lys Pro 
            260                 265                 270         


Arg Cys Ala Asp Ser His Pro Asp Tyr Glu Glu Phe Arg Met Leu Cys 
        275                 280                 285             


Phe Val Asn Asn Ile Gln Val Lys Gly Pro His Asp Leu Glu Leu Arg 
    290                 295                 300                 


Pro Leu Thr Tyr Glu Glu Arg Glu Lys Ile Glu Pro Leu Phe Phe Arg 
305                 310                 315                 320 


Lys Ser Lys Pro Asn Phe Asp Phe Glu Asp Ile Ala Lys Ala Leu Ala 
                325                 330                 335     


Gly Lys Lys Asn Tyr Ala Trp Ile His Asp Lys Glu Glu Arg Ala Tyr 
            340                 345                 350         


Lys Phe Asn Tyr Arg Met Thr Gln Gly Val Pro Gly Cys Pro Thr Ile 
        355                 360                 365             


Ala Gln Leu Lys Ser Ile Phe Gly Asp Asp Trp Lys Thr Gly Ile Ala 
    370                 375                 380                 


Glu Thr Tyr Thr Leu Ile Gln Lys Lys Asn Gly Ser Lys Ser Leu Gln 
385                 390                 395                 400 


Glu Met Val Asp Asp Val Trp Asn Val Leu Tyr Ser Phe Ser Ser Val 
                405                 410                 415     


Glu Lys Leu Lys Glu Phe Ala His His Lys Leu Gln Leu Asp Glu Glu 
            420                 425                 430         


Ser Ala Glu Lys Phe Ala Lys Ile Lys Leu Ser His Ser Phe Ala Ala 
        435                 440                 445             


Leu Ser Leu Lys Ala Ile Arg Lys Phe Leu Pro Phe Leu Arg Lys Gly 
    450                 455                 460                 


Met Tyr Tyr Thr His Ala Ser Phe Phe Ala Asn Ile Pro Thr Ile Val 
465                 470                 475                 480 


Gly Lys Glu Ile Trp Asn Lys Glu Gln Asn Arg Lys Tyr Ile Met Glu 
                485                 490                 495     


Asn Val Gly Glu Leu Val Phe Asn Tyr Gln Pro Lys His Arg Glu Val 
            500                 505                 510         


Gln Gly Thr Ile Glu Met Leu Ile Lys Asp Phe Leu Ala Asn Asn Phe 
        515                 520                 525             


Glu Leu Pro Ala Gly Ala Thr Asp Lys Leu Tyr His Pro Ser Met Ile 
    530                 535                 540                 


Glu Thr Tyr Pro Asn Ala Gln Arg Asn Glu Phe Gly Ile Leu Gln Leu 
545                 550                 555                 560 


Gly Ser Pro Arg Thr Asn Ala Ile Arg Asn Pro Met Ala Met Arg Ser 
                565                 570                 575     


Leu His Ile Leu Arg Arg Val Val Asn Gln Leu Leu Lys Glu Ser Ile 
            580                 585                 590         


Ile Asp Glu Asn Thr Glu Val His Val Glu Tyr Ala Arg Glu Leu Asn 
        595                 600                 605             


Asp Ala Asn Lys Arg Arg Ala Ile Ala Asp Arg Gln Lys Glu Gln Asp 
    610                 615                 620                 


Lys Gln His Lys Lys Tyr Gly Asp Glu Ile Arg Lys Leu Tyr Lys Glu 
625                 630                 635                 640 


Glu Thr Gly Lys Asp Ile Glu Pro Thr Gln Thr Asp Val Leu Lys Phe 
                645                 650                 655     


Gln Leu Trp Glu Glu Gln Asn His His Cys Leu Tyr Thr Gly Glu Gln 
            660                 665                 670         


Ile Gly Ile Thr Asp Phe Ile Gly Ser Asn Pro Lys Phe Asp Ile Glu 
        675                 680                 685             


His Thr Ile Pro Gln Ser Val Gly Gly Asp Ser Thr Gln Met Asn Leu 
    690                 695                 700                 


Thr Leu Cys Asp Asn Arg Phe Asn Arg Glu Val Lys Lys Ala Lys Leu 
705                 710                 715                 720 


Pro Thr Glu Leu Ala Asn His Glu Glu Ile Leu Thr Arg Ile Glu Pro 
                725                 730                 735     


Trp Lys Asn Lys Tyr Glu Gln Leu Val Lys Glu Arg Asp Lys Gln Arg 
            740                 745                 750         


Thr Phe Ala Gly Met Asp Lys Ala Val Lys Asp Ile Arg Ile Gln Lys 
        755                 760                 765             


Arg His Lys Leu Gln Met Glu Ile Asp Tyr Trp Arg Gly Lys Tyr Glu 
    770                 775                 780                 


Arg Phe Thr Met Thr Glu Val Pro Glu Gly Phe Ser Arg Arg Gln Gly 
785                 790                 795                 800 


Thr Gly Ile Gly Leu Ile Ser Arg Tyr Ala Gly Leu Tyr Leu Lys Ser 
                805                 810                 815     


Leu Phe His Gln Ala Asp Ser Arg Asn Lys Ser Asn Val Tyr Val Val 
            820                 825                 830         


Lys Gly Val Ala Thr Ala Glu Phe Arg Lys Met Trp Gly Leu Gln Ser 
        835                 840                 845             


Glu Tyr Glu Lys Lys Cys Arg Asp Asn His Ser His His Cys Met Asp 
    850                 855                 860                 


Ala Ile Thr Ile Ala Cys Ile Gly Lys Arg Glu Tyr Asp Leu Met Ala 
865                 870                 875                 880 


Glu Tyr Tyr Arg Met Glu Glu Thr Phe Lys Gln Gly Arg Gly Ser Lys 
                885                 890                 895     


Pro Lys Phe Ser Lys Pro Trp Ala Thr Phe Thr Glu Asp Val Leu Asn 
            900                 905                 910         


Ile Tyr Lys Asn Leu Leu Val Val His Asp Thr Pro Asn Asn Met Pro 
        915                 920                 925             


Lys His Thr Lys Lys Tyr Val Gln Thr Ser Ile Gly Lys Val Leu Ala 
    930                 935                 940                 


Gln Gly Asp Thr Ala Arg Gly Ser Leu His Leu Asp Thr Tyr Tyr Gly 
945                 950                 955                 960 


Ala Ile Glu Arg Asp Gly Glu Ile Arg Tyr Val Val Arg Arg Pro Leu 
                965                 970                 975     


Ser Ser Phe Thr Lys Pro Glu Glu Leu Glu Asn Ile Val Asp Glu Thr 
            980                 985                 990         


Val Lys Arg Thr Ile Lys Glu Ala  Ile Ala Asp Lys Asn  Phe Lys Gln 
        995                 1000                 1005             


Ala Ile  Ala Glu Pro Ile Tyr  Met Asn Glu Glu Lys  Gly Ile Leu 
    1010                 1015                 1020             


Ile Lys  Lys Val Arg Cys Phe  Ala Lys Ser Val Lys  Gln Pro Ile 
    1025                 1030                 1035             


Asn Ile  Arg Gln His Arg Asp  Leu Ser Lys Lys Glu  Tyr Lys Gln 
    1040                 1045                 1050             


Gln Tyr  His Val Met Asn Glu  Asn Asn Tyr Leu Leu  Ala Ile Tyr 
    1055                 1060                 1065             


Glu Gly  Leu Val Lys Asn Lys  Val Val Arg Glu Phe  Glu Ile Val 
    1070                 1075                 1080             


Ser Tyr  Ile Glu Ala Ala Lys  Tyr Tyr Lys Arg Ser  Gln Asp Arg 
    1085                 1090                 1095             


Asn Ile  Phe Ser Ser Ile Val  Pro Thr His Ser Thr  Lys Tyr Gly 
    1100                 1105                 1110             


Leu Pro  Leu Lys Thr Lys Leu  Leu Met Gly Gln Leu  Val Leu Met 
    1115                 1120                 1125             


Phe Glu  Glu Asn Pro Asp Glu  Ile Gln Val Asp Asn  Thr Lys Asp 
    1130                 1135                 1140             


Leu Val  Lys Arg Leu Tyr Lys  Val Val Gly Ile Glu  Lys Asp Gly 
    1145                 1150                 1155             


Arg Ile  Lys Phe Lys Tyr His  Gln Glu Ala Arg Lys  Glu Gly Leu 
    1160                 1165                 1170             


Pro Ile  Phe Ser Thr Pro Tyr  Lys Asn Asn Asp Asp  Tyr Ala Pro 
    1175                 1180                 1185             


Ile Phe  Arg Gln Ser Ile Asn  Asn Ile Asn Ile Leu  Val Asp Gly 
    1190                 1195                 1200             


Ile Asp  Phe Thr Ile Asp Ile  Leu Gly Lys Val Thr  Leu Lys Glu 
    1205                 1210                 1215             


<210> 405
<211> 1496
<212> PRT
<213> Prevotella veroralis


<220>
<223> Prevotella veroralis F0319

<400> 405
Met Lys Thr Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Lys Val Cys Val Asp Asp Asn Gly Asn Tyr Leu Arg Asp Ile Lys 
            20                  25                  30          


Leu Gly Ser Arg Ile Ile Pro Met Ser Gln Asp Val Leu Gly Asn Phe 
        35                  40                  45              


Asp Lys Gly Val Thr Glu Ser Gln Thr Ser Val Arg Thr Gly Phe Arg 
    50                  55                  60                  


Gly Val Arg Arg Ile Arg Glu Arg Ser Leu Leu Arg Arg Glu Arg Leu 
65                  70                  75                  80  


His Arg Val Leu His Val Leu Gly Tyr Leu Pro Pro His Tyr Asp Ser 
                85                  90                  95      


Ala Ile Gly Trp Asn Lys Asn Glu Pro Ser Thr Tyr Gly Lys Phe Leu 
            100                 105                 110         


Asn His Gly Glu Pro Lys Leu Ala Trp Glu His Lys Glu Asp Gly Ser 
        115                 120                 125             


Met Arg Phe Leu Phe Met Glu Ser Phe His Glu Met Met Ala Asp Phe 
    130                 135                 140                 


Ala Lys Ser Gln Pro Ser Leu Val Ser Asp Gly Lys Lys Ile Pro Leu 
145                 150                 155                 160 


Asp Trp Thr Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Ser Gln Pro Ile 
                165                 170                 175     


Arg Lys Glu Glu Leu Ala Trp Leu Leu Leu Asn Phe Asn Gln Lys Arg 
            180                 185                 190         


Gly Tyr Tyr Gln Leu Arg Gly Glu Glu Asp Asp Asp Asn Pro Thr Lys 
        195                 200                 205             


Cys Glu Glu Tyr Tyr Glu Leu Lys Val Val Gly Ile Glu Ala Asp Glu 
    210                 215                 220                 


Glu Gly Lys Asn Gly Asn Thr Trp Tyr Asn Val Lys Leu Glu Asn Gly 
225                 230                 235                 240 


Trp Ile Tyr Arg Arg Gln Ser Lys Ile Pro Leu Asp Asp Trp Ile Gly 
                245                 250                 255     


Lys Val Arg Glu Phe Ile Val Thr Thr Glu Tyr Glu Lys Asp Gly Ile 
            260                 265                 270         


Thr Leu Lys Lys Asp Lys Asn Gly Asp Val Lys Arg Ser Phe Arg Ser 
        275                 280                 285             


Pro Ser Glu Asp Asp Trp Gly Leu Arg Lys Lys Arg Thr Glu Lys Leu 
    290                 295                 300                 


Leu Asp Ser Ser Lys Met Thr Val Gly Ala Phe Val Tyr Asp His Leu 
305                 310                 315                 320 


Leu Ala Glu Pro Ser Asp Lys Ile Arg Gly Lys Phe Ile Arg Thr Ile 
                325                 330                 335     


Glu Arg Lys Tyr Tyr Lys Lys Glu Leu Tyr Ala Ile Leu Cys Glu Gln 
            340                 345                 350         


Ser Lys Tyr His Glu Glu Leu Arg Ser Gly Asp Tyr Leu Asn Lys Cys 
        355                 360                 365             


Ala Glu Glu Leu Tyr Lys Asn Asn Gln Pro His Arg Asn Ser Leu Leu 
    370                 375                 380                 


Thr Lys Asp Leu Ala Tyr Leu Leu Leu Glu Asp Leu Ile Phe Tyr Gln 
385                 390                 395                 400 


Arg Pro Leu Lys Thr Lys Lys Ser Leu Ile Ala Glu Cys Pro Tyr Glu 
                405                 410                 415     


Ala Tyr Lys Tyr Val Asp Lys Glu Thr Gly Glu Ile Lys Arg Gln Gly 
            420                 425                 430         


Ile Lys Cys Ile Ala Lys Ser Asn Pro Tyr Tyr Gln Glu Phe Arg Leu 
        435                 440                 445             


Trp Gln Phe Ile Ser Asn Leu Arg Leu Phe Asn Lys Ala Asp Asp Lys 
    450                 455                 460                 


Glu Val Thr Ala Asp Tyr Leu Pro Thr Gln Asp Asp Tyr Val Arg Leu 
465                 470                 475                 480 


Phe Ala Tyr Leu Asn Asp Arg Lys Glu Ile Asn Gln Glu Thr Leu Leu 
                485                 490                 495     


Lys Glu Phe Phe Lys Leu Lys Lys Ile Thr Val Asn Ser Glu Lys Val 
            500                 505                 510         


Phe Pro Ile Arg Trp Asn Tyr Ile Glu Asp Lys Glu Lys Lys Tyr Pro 
        515                 520                 525             


Cys Asn Glu Thr Arg His Glu Leu Leu Leu Ala Leu Asp Arg Ala Arg 
    530                 535                 540                 


Ile Asp His Ser Trp Leu Glu Lys Pro Gly Gln Glu Tyr Arg Leu Trp 
545                 550                 555                 560 


His Leu Leu Tyr Ser Val Glu Ser Lys Glu Glu Thr Lys Glu Ala Leu 
                565                 570                 575     


Arg Lys Leu Lys Asp Asp Asp Ala Phe Val Glu Ser Phe Leu Lys Val 
            580                 585                 590         


Lys Pro Phe Lys Arg Glu Tyr Gly Ala Tyr Ser Glu Lys Ala Ile Lys 
        595                 600                 605             


Lys Leu Leu Ala Val Met Arg Met Gly Ser Leu Trp Arg Glu Thr Asp 
    610                 615                 620                 


Ile Cys Asp Thr Thr Lys Gly Asn Ile Thr Lys Ile Leu Gln Gly Glu 
625                 630                 635                 640 


Ile Asp Glu Lys Leu Lys Glu Lys Ile Ser Ala Ser Val Ser Ser Tyr 
                645                 650                 655     


Asn Gln Leu Ser Asp Phe Gln Gly Leu Pro Val Trp Leu Ala Cys Tyr 
            660                 665                 670         


Val Val Tyr Gly Arg His Ser Glu Ala Ala Glu Ile Gln His Trp Lys 
        675                 680                 685             


Thr Pro Glu Ser Leu Leu Ala Tyr Ile Asn Gly Phe Lys Gln His Ser 
    690                 695                 700                 


Leu Arg Asn Pro Ile Val Glu Gln Cys Ile Leu Glu Thr Leu Arg Thr 
705                 710                 715                 720 


Val His Asp Ile Trp Lys Glu Val Gly His Ile Asp Glu Ile His Val 
                725                 730                 735     


Glu Leu Gly Arg Asn Met Lys Ser Thr Ala Asp Gln Arg Ala Arg Ile 
            740                 745                 750         


Ser Glu Asn Val Leu Arg Asn Glu Asn Thr Asn Leu Arg Ile Lys Ser 
        755                 760                 765             


Leu Leu Leu Glu Leu Lys Asn Asp Pro Asn Ile Lys Asp Val Arg Pro 
    770                 775                 780                 


Tyr Ser Pro Met Gln Gln Glu Lys Leu Arg Ile Tyr Glu Glu Gly Val 
785                 790                 795                 800 


Leu Gln Glu Leu Thr Lys Asp Asp Lys Asp Phe Thr Glu Ile Thr Lys 
                805                 810                 815     


Ile Ser Thr Met Ala Gln Pro Ser Ala Lys Glu Leu Gln Arg Tyr Lys 
            820                 825                 830         


Leu Trp Leu Glu Gln Lys Tyr Arg Ser Pro Tyr Thr Gly Lys Ser Ile 
        835                 840                 845             


Ser Leu Thr Lys Leu Phe Thr Ser Ala Tyr Gln Ile Glu His Val Ile 
    850                 855                 860                 


Pro Gln Ser Arg Tyr Phe Asp Asp Ser Phe Ser Asn Lys Val Ile Cys 
865                 870                 875                 880 


Glu Ser Glu Val Asn Ser Leu Lys Asp Asn Met Leu Gly Tyr Glu Phe 
                885                 890                 895     


Ile Lys Asn His Gly Gly Glu Ile Ile His Cys Thr Met Leu Gly Asp 
            900                 905                 910         


Val Lys Val Leu Ser Glu Ser Glu Tyr Lys Ala Phe Val Asn Asp His 
        915                 920                 925             


Tyr Ala His Asn Lys Arg Lys Arg Glu Asn Leu Leu Leu Glu Asp Ile 
    930                 935                 940                 


Pro Gln Glu Phe Leu Asn Arg Gln Met Asn Asp Ser Arg Tyr Ile Ser 
945                 950                 955                 960 


Lys Val Val Lys Ala Leu Leu Ser Asn Ile Val Arg Ala Glu Gly Glu 
                965                 970                 975     


Glu Glu Ala Thr Ser Lys Phe Val Val Ser Cys Ser Gly Gly Ile Thr 
            980                 985                 990         


Asp Arg Leu Lys Lys Asp Trp Gly  Leu Asn Asp Val Trp  Asn Lys Ile 
        995                 1000                 1005             


Val Tyr  Pro Arg Phe Glu Arg  Leu Asn Arg Leu Thr  Gly Thr Glu 
    1010                 1015                 1020             


Ala Phe  Gly Gln Trp Glu Asn  Lys Asp Gly Lys Arg  Val Phe Gln 
    1025                 1030                 1035             


Thr Ala  Val Pro Leu Glu Leu  Gln Arg Gly Phe Asn  Lys Lys Arg 
    1040                 1045                 1050             


Ile Asp  His Arg His His Ala  Met Asp Ala Leu Val  Ile Ala Cys 
    1055                 1060                 1065             


Thr Ser  Arg Asn Ile Ile Asn  Tyr Leu Asn Asn Glu  Ser Ala Asn 
    1070                 1075                 1080             


Asn Pro  Lys Lys Arg Glu Asp  Leu Arg Gln Lys Leu  Cys Asp Lys 
    1085                 1090                 1095             


Asn Arg  Thr Ile Arg Lys Pro  Trp Glu Thr Phe Thr  Gln Asp Ala 
    1100                 1105                 1110             


Thr Ala  Ala Leu Glu Asp Val  Ile Val Ser Phe Lys  Asn Tyr Val 
    1115                 1120                 1125             


Arg Ile  Ile Asn Lys Ala Thr  Asn Tyr Tyr Glu Arg  Tyr Asp Val 
    1130                 1135                 1140             


Glu Gly  Lys Lys Val Ile Ala  Glu Gln Arg Gly Asp  Asp Met Trp 
    1145                 1150                 1155             


Ala Ile  Arg Lys Pro Met His  Glu Ala Thr Tyr Tyr  Gly Arg Val 
    1160                 1165                 1170             


Asn Leu  Arg Arg Lys Lys Lys  Val Asn Leu Arg Val  Ala Leu Glu 
    1175                 1180                 1185             


Asn Ile  Ser Ser Ile Cys Asp  Asn Lys Leu Arg Ile  Tyr Ile Asn 
    1190                 1195                 1200             


Gly Leu  Val Glu Lys Gly Phe  Asn Thr Lys Gln Ile  Leu Asp Lys 
    1205                 1210                 1215             


Phe Lys  Asn Thr Asn Asp His  Phe Ser Met Gln Lys  Ile Asp Lys 
    1220                 1225                 1230             


Val Glu  Ile Trp Gln Phe Thr  Asn Glu Glu Glu Lys  Leu Val Ala 
    1235                 1240                 1245             


Thr Arg  Lys Pro Leu Asp Thr  Ser Phe Asp Thr Lys  Lys Ile Ala 
    1250                 1255                 1260             


Ser Ile  Thr Asp Thr Gly Ile  Gln Thr Ile Leu Leu  Asn Tyr Leu 
    1265                 1270                 1275             


Glu Thr  Lys Gly Gly Asp Ser  Thr Ile Ala Phe Thr  Pro Glu Gly 
    1280                 1285                 1290             


Ile Val  Glu Met Asn Gln Asn  Ile Ser Lys Tyr Asn  Asn Gly Lys 
    1295                 1300                 1305             


Glu His  Met Pro Ile Leu Lys  Val Arg Leu Tyr Thr  Lys Leu Gly 
    1310                 1315                 1320             


Lys Lys  Ile Pro Val Gly Gln  Thr Gly Cys Lys Ala  Lys Gln Phe 
    1325                 1330                 1335             


Val Ile  Ala Glu Ala Gly Thr  Asn Leu Tyr Phe Ala  Ile Tyr Glu 
    1340                 1345                 1350             


Asp Glu  Glu Gly Lys Arg Ser  Tyr Arg Thr Ile Pro  Leu Asn Glu 
    1355                 1360                 1365             


Val Val  Glu Arg Leu Lys Gln  Gly Leu Ser Pro Val  Pro Glu Lys 
    1370                 1375                 1380             


Asn Asp  Lys Asp Val His Leu  Lys Phe Tyr Leu Ser  Pro Asn Asp 
    1385                 1390                 1395             


Leu Val  Tyr Val Pro Ile Glu  Asp Glu His Glu Ser  Leu Ala Lys 
    1400                 1405                 1410             


Asp His  Ile Tyr Lys Phe Val  Asp Ser Ser Gly Thr  Thr Ala Asn 
    1415                 1420                 1425             


Phe Ile  Pro His Arg Ser Ala  Asn Val Ile Phe Glu  Leu Asn Lys 
    1430                 1435                 1440             


Lys Asp  Ala Glu Lys Phe Cys  Ser Gly Ser Ile Ile  Gln Asn Glu 
    1445                 1450                 1455             


Tyr Gly  Val Gly Ser Ser Gln  Ser Lys Asn Gln Lys  Ala Ile Thr 
    1460                 1465                 1470             


Gly Glu  Met Ile Lys Ala Val  Cys Arg Lys Leu Glu  Val Asp Arg 
    1475                 1480                 1485             


Leu Gly  Asn Val Ile Lys Val  Ile 
    1490                 1495     


<210> 406
<211> 1062
<212> PRT
<213> Ralstonia syzygii


<220>
<223> Ralstonia syzygii R24

<400> 406
Met Ala Glu Lys Gln His Arg Trp Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Ile Gly Trp Ala Val Ile Ala Leu Ile Glu Gly Arg Pro Ala Gly Leu 
            20                  25                  30          


Val Ala Thr Gly Ser Arg Ile Phe Ser Asp Gly Arg Asn Pro Lys Asp 
        35                  40                  45              


Gly Ser Ser Leu Ala Val Glu Arg Arg Gly Pro Arg Gln Met Arg Arg 
    50                  55                  60                  


Arg Arg Asp Arg Tyr Leu Arg Arg Arg Asp Arg Phe Met Gln Ala Leu 
65                  70                  75                  80  


Ile Asn Val Gly Leu Met Pro Gly Asp Ala Ala Ala Arg Lys Ala Leu 
                85                  90                  95      


Val Thr Glu Asn Pro Tyr Val Leu Arg Gln Arg Gly Leu Asp Gln Ala 
            100                 105                 110         


Leu Thr Leu Pro Glu Phe Gly Arg Ala Leu Phe His Leu Asn Gln Arg 
        115                 120                 125             


Arg Gly Phe Gln Ser Asn Arg Lys Thr Asp Arg Ala Thr Ala Lys Glu 
    130                 135                 140                 


Ser Gly Lys Val Lys Asn Ala Ile Ala Ala Phe Arg Ala Gly Met Gly 
145                 150                 155                 160 


Asn Ala Arg Thr Val Gly Glu Ala Leu Ala Arg Arg Leu Glu Asp Gly 
                165                 170                 175     


Arg Pro Val Arg Ala Arg Met Val Gly Gln Gly Lys Asp Glu His Tyr 
            180                 185                 190         


Glu Leu Tyr Ile Ala Arg Glu Trp Ile Ala Gln Glu Phe Asp Ala Leu 
        195                 200                 205             


Trp Ala Ser Gln Gln Arg Phe His Ala Glu Val Leu Ala Asp Ala Ala 
    210                 215                 220                 


Arg Asp Arg Leu Arg Ala Ile Leu Leu Phe Gln Arg Lys Leu Leu Pro 
225                 230                 235                 240 


Val Pro Val Gly Lys Cys Phe Leu Glu Pro Asn Gln Pro Arg Val Ala 
                245                 250                 255     


Ala Ala Leu Pro Ser Ala Gln Arg Phe Arg Leu Met Gln Glu Leu Asn 
            260                 265                 270         


His Leu Arg Val Met Thr Leu Ala Asp Lys Arg Glu Arg Pro Leu Ser 
        275                 280                 285             


Phe Gln Glu Arg Asn Asp Leu Leu Ala Gln Leu Val Ala Arg Pro Lys 
    290                 295                 300                 


Cys Gly Phe Asp Met Leu Arg Lys Ile Val Phe Gly Ala Asn Lys Glu 
305                 310                 315                 320 


Ala Tyr Arg Phe Thr Ile Glu Ser Glu Arg Arg Lys Glu Leu Lys Gly 
                325                 330                 335     


Cys Asp Thr Ala Ala Lys Leu Ala Lys Val Asn Ala Leu Gly Thr Arg 
            340                 345                 350         


Trp Gln Ala Leu Ser Leu Asp Glu Gln Asp Arg Leu Val Cys Leu Leu 
        355                 360                 365             


Leu Asp Gly Glu Asn Asp Ala Val Leu Ala Asp Ala Leu Arg Glu His 
    370                 375                 380                 


Tyr Gly Leu Thr Asp Ala Gln Ile Asp Thr Leu Leu Gly Leu Ser Phe 
385                 390                 395                 400 


Glu Asp Gly His Met Arg Leu Gly Arg Ser Ala Leu Leu Arg Val Leu 
                405                 410                 415     


Asp Ala Leu Glu Ser Gly Arg Asp Glu Gln Gly Leu Pro Leu Ser Tyr 
            420                 425                 430         


Asp Lys Ala Val Val Ala Ala Gly Tyr Pro Ala His Thr Ala Asp Leu 
        435                 440                 445             


Glu Asn Gly Glu Arg Asp Ala Leu Pro Tyr Tyr Gly Glu Leu Leu Trp 
    450                 455                 460                 


Arg Tyr Thr Gln Asp Ala Pro Thr Ala Lys Asn Asp Ala Glu Arg Lys 
465                 470                 475                 480 


Phe Gly Lys Ile Ala Asn Pro Thr Val His Ile Gly Leu Asn Gln Leu 
                485                 490                 495     


Arg Lys Leu Val Asn Ala Leu Ile Gln Arg Tyr Gly Lys Pro Ala Gln 
            500                 505                 510         


Ile Val Val Glu Leu Ala Arg Asn Leu Lys Ala Gly Leu Glu Glu Lys 
        515                 520                 525             


Glu Arg Ile Lys Lys Gln Gln Thr Ala Asn Leu Glu Arg Asn Glu Arg 
    530                 535                 540                 


Ile Arg Gln Lys Leu Gln Asp Ala Gly Val Pro Asp Asn Arg Glu Asn 
545                 550                 555                 560 


Arg Leu Arg Met Arg Leu Phe Glu Glu Leu Gly Gln Gly Asn Gly Leu 
                565                 570                 575     


Gly Thr Pro Cys Ile Tyr Ser Gly Arg Gln Ile Ser Leu Gln Arg Leu 
            580                 585                 590         


Phe Ser Asn Asp Val Gln Val Asp His Ile Leu Pro Phe Ser Lys Thr 
        595                 600                 605             


Leu Asp Asp Ser Phe Ala Asn Lys Val Leu Ala Gln His Asp Ala Asn 
    610                 615                 620                 


Arg Tyr Lys Gly Asn Arg Gly Pro Phe Glu Ala Phe Gly Ala Asn Arg 
625                 630                 635                 640 


Asp Gly Tyr Ala Trp Asp Asp Ile Arg Ala Arg Ala Ala Val Leu Pro 
                645                 650                 655     


Arg Asn Lys Arg Asn Arg Phe Ala Glu Thr Ala Met Gln Asp Trp Leu 
            660                 665                 670         


His Asn Glu Thr Asp Phe Leu Ala Arg Gln Leu Thr Asp Thr Ala Tyr 
        675                 680                 685             


Leu Ser Arg Val Ala Arg Gln Tyr Leu Thr Ala Ile Cys Ser Lys Asp 
    690                 695                 700                 


Asp Val Tyr Val Ser Pro Gly Arg Leu Thr Ala Met Leu Arg Ala Lys 
705                 710                 715                 720 


Trp Gly Leu Asn Arg Val Leu Asp Gly Val Met Glu Glu Gln Gly Arg 
                725                 730                 735     


Pro Ala Val Lys Asn Arg Asp Asp His Arg His His Ala Ile Asp Ala 
            740                 745                 750         


Val Val Ile Gly Ala Thr Asp Arg Ala Met Leu Gln Gln Val Ala Thr 
        755                 760                 765             


Leu Ala Ala Arg Ala Arg Glu Gln Asp Ala Glu Arg Leu Ile Gly Asp 
    770                 775                 780                 


Met Pro Thr Pro Trp Pro Asn Phe Leu Glu Asp Val Arg Ala Ala Val 
785                 790                 795                 800 


Ala Arg Cys Val Val Ser His Lys Pro Asp His Gly Pro Glu Gly Gly 
                805                 810                 815     


Leu His Asn Asp Thr Ala Tyr Gly Ile Val Ala Gly Pro Phe Glu Asp 
            820                 825                 830         


Gly Arg Tyr Arg Val Arg His Arg Val Ser Leu Phe Asp Leu Lys Pro 
        835                 840                 845             


Gly Asp Leu Ser Asn Val Arg Cys Asp Ala Pro Leu Gln Ala Glu Leu 
    850                 855                 860                 


Glu Pro Ile Phe Glu Gln Asp Asp Ala Arg Ala Arg Glu Val Ala Leu 
865                 870                 875                 880 


Thr Ala Leu Ala Glu Arg Tyr Arg Gln Arg Lys Val Trp Leu Glu Glu 
                885                 890                 895     


Leu Met Ser Val Leu Pro Ile Arg Pro Arg Gly Glu Asp Gly Lys Thr 
            900                 905                 910         


Leu Pro Asp Ser Ala Pro Tyr Lys Ala Tyr Lys Gly Asp Ser Asn Tyr 
        915                 920                 925             


Cys Tyr Glu Leu Phe Ile Asn Glu Arg Gly Arg Trp Asp Gly Glu Leu 
    930                 935                 940                 


Ile Ser Thr Phe Arg Ala Asn Gln Ala Ala Tyr Arg Arg Phe Arg Asn 
945                 950                 955                 960 


Asp Pro Ala Arg Phe Arg Arg Tyr Thr Ala Gly Gly Arg Pro Leu Leu 
                965                 970                 975     


Met Arg Leu Cys Ile Asn Asp Tyr Ile Ala Val Gly Thr Ala Ala Glu 
            980                 985                 990         


Arg Thr Ile Phe Arg Val Val Lys  Met Ser Glu Asn Lys  Ile Thr Leu 
        995                 1000                 1005             


Ala Glu  His Phe Glu Gly Gly  Thr Leu Lys Gln Arg  Asp Ala Asp 
    1010                 1015                 1020             


Lys Asp  Asp Pro Phe Lys Tyr  Leu Thr Lys Ser Pro  Gly Ala Leu 
    1025                 1030                 1035             


Arg Asp  Leu Gly Ala Arg Arg  Ile Phe Val Asp Leu  Ile Gly Arg 
    1040                 1045                 1050             


Val Leu  Asp Pro Gly Ile Lys  Gly Asp 
    1055                 1060         


<210> 407
<211> 1066
<212> PRT
<213> Rhodopseudomonas palustris

<400> 407
Met Ser Glu Arg Val Val Arg Arg Ile Leu Gly Ile Asp Leu Gly Ile 
1               5                   10                  15      


Ala Ser Cys Gly Trp Gly Val Val Asp Ile Ser Gly Ala Gly Gly Gly 
            20                  25                  30          


Ile Ile Ala Thr Gly Val Arg Cys Phe Asp Ala Pro Leu Ile Asp Lys 
        35                  40                  45              


Thr Gly Glu Pro Lys Ser Ala Thr Arg Arg Thr Ala Arg Gly Gln Arg 
    50                  55                  60                  


Arg Ile Val Arg Arg Arg Arg Gln Arg Met Asn Gly Val Arg Arg Leu 
65                  70                  75                  80  


Leu Cys Glu Phe Gly Leu Leu Pro Asp Pro Arg Pro Asp Ala Leu Asn 
                85                  90                  95      


Gln Ala Met Arg Arg Ile Ser Thr Ala Ser Ala Ala Ala Gln Val Thr 
            100                 105                 110         


Pro Trp Thr Leu Arg Ala Ala Ala His Gln Arg Leu Leu Ser Asn Glu 
        115                 120                 125             


Glu Leu Ala Val Val Leu Gly His Ile Ala Arg His Arg Gly Phe Arg 
    130                 135                 140                 


Ser Asn Ala Lys Asn Glu Ala Gly Ala Asn Ala Ala Asp Glu Thr Ser 
145                 150                 155                 160 


Lys Met Lys Lys Ala Met Glu Ala Thr Arg Glu Gly Leu Ala Lys Tyr 
                165                 170                 175     


His Ala Phe Gly Asp Met Ile Ala Asn Asp Pro Lys Phe Ala Asn Arg 
            180                 185                 190         


Lys Arg Asn Arg Asp Lys Asp Tyr Ser His Thr Ala Lys Arg Ser Asp 
        195                 200                 205             


Leu Glu Asp Glu Val Arg Ala Ile Leu Arg Ala Gln Leu Arg Phe Gly 
    210                 215                 220                 


Ser Ala Ala Ala Thr Glu Thr Leu Ala Gln Thr Phe Ala Asp Val Ala 
225                 230                 235                 240 


Phe Phe Gln Arg Pro Leu Gln Asp Ser Glu Asp Arg Val Gly Asp Cys 
                245                 250                 255     


Pro Phe Glu Pro Gly Gln Lys Arg Ala Ala Arg Arg Ala Pro Ser Phe 
            260                 265                 270         


Glu Leu Phe Arg Phe Leu Ser Arg Leu Ala Asn Leu Lys Leu Ala Val 
        275                 280                 285             


Gly Arg Ser Pro Glu Arg Arg Leu Thr Ala Glu Glu Ile Ala Leu Ala 
    290                 295                 300                 


Ala Lys Gly Phe Gly Glu Thr Lys Lys Thr Ile Thr Phe Lys Ser Leu 
305                 310                 315                 320 


Arg Glu Ala Leu Asp Leu Asp Pro Asn Ala Arg Phe Ser Gly Ile Gly 
                325                 330                 335     


Lys Asp Lys Glu Ala Ser Leu Asp Val Val Ala Arg Thr Gly Gly Ala 
            340                 345                 350         


Ala Tyr Gly Thr Lys Thr Leu Lys Asp Ala Leu Gly Asp Ala Pro Trp 
        355                 360                 365             


Arg Ser Leu Ser Arg Thr Pro Glu Thr Leu Asp Arg Ile Ala Glu Ile 
    370                 375                 380                 


Leu Ser Phe Arg Glu Asp Ile Thr Ser Ile Arg Asn Gly Leu Glu Asp 
385                 390                 395                 400 


Leu Gly Leu Asp Ser Leu Val Val Glu Ala Leu Met Gln Ala Ala Ala 
                405                 410                 415     


Asn Gly Asp Phe Lys Glu Phe Thr Arg Ala Gly His Ile Ser Ala Arg 
            420                 425                 430         


Ala Ala Arg Asn Ile Ile Pro Gly Leu Arg Glu Gly Leu Val Tyr Ser 
        435                 440                 445             


Glu Ala Cys Ala Arg Val Gly Tyr Asp His Ala Ala Arg Leu Ser Val 
    450                 455                 460                 


Pro Leu Asp Gln Val Gly Ser Pro Val Thr Arg Lys Ala Leu Ser Glu 
465                 470                 475                 480 


Ala Leu Lys Gln Val Arg Ala Val Ala Arg Glu Tyr Gly Pro Ile Asp 
                485                 490                 495     


Tyr Phe His Ile Glu Leu Ala Arg Ser Val Gly Lys Ser Ala Glu Glu 
            500                 505                 510         


Arg Lys Gln Leu Thr Asp Gly Ile Glu Ala Arg Asn Val Glu Lys Ala 
        515                 520                 525             


Lys Arg Arg Lys Gln Ala Glu Glu His Leu Gly Arg Ala Pro Ser Asp 
    530                 535                 540                 


Asp Glu Leu Leu Arg Tyr Glu Leu Ala Lys Glu Gln Asn Phe Lys Cys 
545                 550                 555                 560 


Ile Tyr Ser Gly Asp Ala Ile Asp Pro Ala Gly Val Ala Ala Asn Asp 
                565                 570                 575     


Thr Arg Tyr Gln Val Asp His Ile Leu Pro Trp Ser Arg Phe Gly Asp 
            580                 585                 590         


Asp Ser Tyr Leu Asn Lys Thr Leu Cys Thr Ala Arg Ser Asn Gln Asn 
        595                 600                 605             


Lys Arg Gly Arg Thr Pro Phe Glu Trp Phe Glu Ala Asp Lys Thr Asp 
    610                 615                 620                 


Val Glu Trp Met Glu Tyr Val Ala Arg Val Glu Asn Leu Gln Glu Val 
625                 630                 635                 640 


Lys Gly Arg Lys Lys Arg Asn Tyr Ser Ile Lys Asp Ala Ala Ala Ile 
                645                 650                 655     


Glu Asp Lys Phe Lys Ala Arg Asn Leu Thr Asp Thr Gln Trp Ala Thr 
            660                 665                 670         


Arg Leu Leu Ala Asp Glu Leu Ser Arg Met Phe Pro Pro Arg Glu Cys 
        675                 680                 685             


Glu Arg Ala Ile Cys Gly Arg Ala Asp Gly Gly Asn Asp Gly Leu Thr 
    690                 695                 700                 


Ile Val Glu Glu Arg Arg Val Phe Thr Arg Pro Gly Ala Ile Thr Ser 
705                 710                 715                 720 


Lys Leu Arg Arg Ala Trp Gly Leu Glu Gly Leu Lys Lys Gln Asp Gly 
                725                 730                 735     


Lys Arg Val Glu Asp Asp Arg His His Ala Val Asp Ala Leu Val Leu 
            740                 745                 750         


Ala Ala Thr Thr Glu Ser Leu Leu Gln Arg Leu Thr Val Glu Val Gln 
        755                 760                 765             


Arg Arg Glu Arg Glu Gly Arg Pro Asp Asp Ile Phe His Cys Ala Glu 
    770                 775                 780                 


Pro Trp Arg Gly Phe Arg Ala Asp Val Arg Arg Thr Val Tyr Gly Ser 
785                 790                 795                 800 


Glu Thr Met Pro Gly Ile Phe Val Ser Arg Ala Glu Arg Arg Arg Ala 
                805                 810                 815     


Arg Gly Lys Ala His Asp Ala Thr Ile Lys Gln Ile Arg Glu Ile Glu 
            820                 825                 830         


Gly Glu Arg Leu Val Phe Glu Arg Lys Pro Val Glu Lys Leu Thr Asp 
        835                 840                 845             


Lys Asp Leu Glu Lys Ile Pro Ile Pro Lys Pro Tyr Gly Gln Val Ser 
    850                 855                 860                 


Asp Pro Lys Arg Leu Arg Asp Glu Leu Val Glu Ser Leu Arg Ala Trp 
865                 870                 875                 880 


Ile Ala Ala Gly Lys Pro Lys Asp Arg Pro Pro Leu Ser Pro Lys Gly 
                885                 890                 895     


Asp Val Ile Arg Lys Val Arg Ile Gln Thr Asn Asp Lys Val Ser Val 
            900                 905                 910         


Glu Ile Asn Gly Gly Thr Val Asp Arg Gly Asp Met Ala Arg Val Asp 
        915                 920                 925             


Val Phe Arg Lys Lys Asn Lys Lys Ala Val Trp Glu Tyr Tyr Val Val 
    930                 935                 940                 


Pro Ile Tyr Pro His Gln Ile Val Ala Leu Asn Asp Pro Pro Asp Arg 
945                 950                 955                 960 


Ala Val Ile Ala Tyr Ala Glu Asp Lys Asp Trp Lys Glu Ile Asp Ser 
                965                 970                 975     


Ser Tyr Glu Phe Leu Trp Ser Leu Phe Gly Leu Ser Tyr Val Glu Ile 
            980                 985                 990         


Ser Lys Ala Asn Gly Glu Cys Ile  Asp Gly Tyr Phe Arg  Gly Leu His 
        995                 1000                 1005             


Arg Gly  Thr Gly Ala Ala Ser  Val Cys Lys His Ile  Ser Leu Gly 
    1010                 1015                 1020             


Lys Asp  Ala Thr Val Ser Gly  Ile Gly Leu Lys Thr  Leu Ala Ser 
    1025                 1030                 1035             


Phe Lys  Lys Phe Thr Ile Asp  Arg Leu Gly Arg Lys  Phe Glu Ile 
    1040                 1045                 1050             


Pro Arg  Glu Val Arg Thr Trp  Arg Gly Glu Ala Cys  Thr 
    1055                 1060                 1065     


<210> 408
<211> 1064
<212> PRT
<213> Rhodopseudomonas palustris

<400> 408
Met Ser Glu Cys Val Thr Arg Arg Ile Leu Gly Ile Asp Leu Gly Ile 
1               5                   10                  15      


Ala Ser Cys Gly Trp Gly Val Ile Glu Val Gly Glu Ala Ser Gly Ser 
            20                  25                  30          


Ile Ile Ala Ser Gly Val Arg Cys Phe Asp Ala Pro Leu Ile Asp Lys 
        35                  40                  45              


Thr Gly Glu Pro Lys Ser Ala Thr Arg Arg Thr Ala Arg Gly Gln Arg 
    50                  55                  60                  


Arg Ile Ile Arg Arg Arg Arg Gln Arg Met Asn Ala Val Arg Arg Leu 
65                  70                  75                  80  


Leu Ala Glu Phe Gly Val Leu Thr Gly Arg Ser Pro Asp Ala Leu His 
                85                  90                  95      


Gln Ala Leu Leu Arg Leu Ser Gln Ser Val Ala Gly Ser Gln Val Thr 
            100                 105                 110         


Pro Trp Thr Leu Arg Ala Ala Ala His Glu Arg Lys Leu Thr Asn Asp 
        115                 120                 125             


Glu Leu Ala Val Val Leu Gly His Ile Ala Arg His Arg Gly Phe Arg 
    130                 135                 140                 


Ser Asn Ser Lys Asn Asp Gly Gly Ala Asn Ala Ala Asp Glu Thr Ser 
145                 150                 155                 160 


Lys Met Lys Lys Ala Met Glu Thr Thr Arg Glu Gly Leu Ala Arg Tyr 
                165                 170                 175     


His Ser Phe Gly Ala Met Ile Ala Ser Asp Pro Lys Phe Ala Asp Arg 
            180                 185                 190         


Lys Arg Asn Arg Asp Lys Asp Tyr Ser His Thr Ala Lys Arg Ser Asp 
        195                 200                 205             


Leu Glu Asp Glu Val Arg Thr Ile Phe Arg Ser Gln Thr Arg Phe Gly 
    210                 215                 220                 


Ser Leu Val Ala Ser Glu Lys Leu Ser Gln Ala Phe Ala Asp Ala Ala 
225                 230                 235                 240 


Phe Phe Gln Arg Pro Leu Gln Asp Ser Glu Asp Met Val Gly Ser Cys 
                245                 250                 255     


Pro Phe Glu Pro Gly Gln Lys Arg Thr Ala Arg Arg Ala Pro Ser Phe 
            260                 265                 270         


Glu Leu Phe Arg Phe Leu Ser Arg Leu Ala Asn Leu Lys Leu Thr Val 
        275                 280                 285             


Gly Arg Ala Pro Glu Arg Arg Leu Thr Pro Asp Glu Ile Ala Leu Ala 
    290                 295                 300                 


Ala Lys Gly Phe Gly Glu Thr Lys Lys Ser Ile Thr Phe Lys Ser Leu 
305                 310                 315                 320 


Arg Glu Ala Leu Asp Leu Asp Pro Asn Ala Arg Phe Ser Gly Val Ala 
                325                 330                 335     


Lys Glu Lys Glu Ser Thr Leu Asp Val Ala Ala Arg Thr Gly Gly Ala 
            340                 345                 350         


Ala Tyr Gly Thr Lys Thr Leu Lys Asp Ala Leu Gly Asp Ala Pro Trp 
        355                 360                 365             


Arg Ser Leu Ser Arg Met Pro Glu Lys Leu Asp Arg Ile Ala Glu Ile 
    370                 375                 380                 


Leu Ser Phe Arg Glu Asp Met Lys Ala Ile Arg Asn Gly Leu Glu Glu 
385                 390                 395                 400 


Val Gly Leu Asp Gly Leu Val Val Asp Ala Leu Met Gln Ala Thr Ala 
                405                 410                 415     


Asn Gly Asp Phe Lys Asp Phe Thr Arg Ala Ala His Ile Ser Ala Leu 
            420                 425                 430         


Ala Ala Arg Asn Ile Ile Pro Gly Leu Arg Glu Gly Leu Val Tyr Ser 
        435                 440                 445             


Asp Ala Cys Thr Arg Val Gly Tyr Asp His Ala Ala Arg Pro Ala Val 
    450                 455                 460                 


Pro Leu Ser Gln Ile Gly Ser Pro Val Thr Arg Lys Ala Leu Ser Glu 
465                 470                 475                 480 


Ala Leu Lys Gln Val Arg Ala Val Ala Arg Glu Tyr Gly Pro Ile Asp 
                485                 490                 495     


Tyr Phe His Ile Glu Leu Ala Arg Ser Ile Gly Lys Ser Ala Glu Glu 
            500                 505                 510         


Arg Lys Lys Leu Thr Asp Gly Ile Glu Ala Arg Asn Val Glu Lys Glu 
        515                 520                 525             


Lys Arg Arg Lys Glu Ala Ala Glu His Leu Gly Arg Ala Pro Ser Asp 
    530                 535                 540                 


Asp Glu Leu Leu Arg Tyr Glu Leu Ala Lys Glu Gln Asn Phe Lys Cys 
545                 550                 555                 560 


Ile Tyr Ser Gly Asp Pro Ile Asp Pro Ala Gly Ile Ser Ala Asn Asp 
                565                 570                 575     


Thr Arg Tyr Gln Val Asp His Ile Leu Pro Trp Ser Arg Phe Gly Asp 
            580                 585                 590         


Asp Ser Tyr Val Asn Lys Thr Leu Cys Thr Ala Arg Ser Asn Gln Asn 
        595                 600                 605             


Lys Arg Gly Arg Thr Pro Phe Glu Trp Phe Asp Ala Asp Lys Thr Glu 
    610                 615                 620                 


Ala Glu Trp Met Glu Tyr Ser Ala Arg Val Glu Asp Leu Lys Glu Val 
625                 630                 635                 640 


Lys Gly Arg Lys Lys Arg Asn Tyr Ser Ile Lys Asp Ala Ala Ser Val 
                645                 650                 655     


Glu Asp Lys Phe Lys Ala Arg Asn Leu Thr Asp Thr Gln Trp Ala Thr 
            660                 665                 670         


Arg Leu Leu Ala Asp Glu Leu Lys Arg Met Phe Pro Pro Arg Glu Cys 
        675                 680                 685             


Glu Arg Val Val Thr Val Arg Ala Asp Gly Gly Asn Asp Gly Leu Ser 
    690                 695                 700                 


Ile Val Glu Glu Arg Arg Val Phe Thr Arg Pro Gly Ala Ile Thr Ser 
705                 710                 715                 720 


Lys Leu Arg Arg Ala Trp Gly Leu Glu Gly Leu Lys Lys Gln Asp Gly 
                725                 730                 735     


Lys Arg Val Glu Asp Asp Arg His His Ala Val Asp Ala Leu Val Leu 
            740                 745                 750         


Ala Ala Thr Thr Glu Ser Leu Leu Asn Arg Leu Thr Val Glu Val Gln 
        755                 760                 765             


Gln Arg Glu Arg Glu Gly Arg Gln Asp Asp Ile Phe His Cys Ser Gln 
    770                 775                 780                 


Pro Trp Pro Gly Phe Arg Val Asp Val Gln Arg Thr Val Tyr Gly Ser 
785                 790                 795                 800 


Glu Thr Met Pro Gly Ile Phe Val Ser Arg Ala Glu Arg Arg Arg Ala 
                805                 810                 815     


Arg Gly Lys Ala His Asp Ala Thr Val Lys Gln Ile Arg Asp Ile Asp 
            820                 825                 830         


Gly Glu Arg Ile Val Phe Glu Arg Lys Pro Ile Glu Lys Leu Thr Asp 
        835                 840                 845             


Lys Asp Leu Glu Arg Ile Pro Val Pro Glu Pro Tyr Gly Lys Ala Ala 
    850                 855                 860                 


Asp Pro Lys Lys Leu Arg Asp Glu Leu Val Glu Asn Leu Arg Ala Trp 
865                 870                 875                 880 


Ile Ala Ala Gly Lys Pro Lys Asp Lys Pro Pro Arg Ser Pro Lys Gly 
                885                 890                 895     


Asp Ile Ile Arg Lys Val Arg Ile Glu Thr Lys Asp Lys Val Ala Val 
            900                 905                 910         


Glu Ile Asn Gly Gly Thr Val Asp Arg Gly Asp Met Ala Arg Val Asp 
        915                 920                 925             


Val Phe Arg Lys Lys Asn Lys Lys Gly Val Trp Glu Phe Tyr Val Ile 
    930                 935                 940                 


Pro Ile Tyr Pro His Gln Ile Val Ala Ser Ala Leu Pro Pro Asn Arg 
945                 950                 955                 960 


Ala Val Ile Ala Tyr Lys Ala Glu Ser Glu Trp Thr Ala Ile Asp Gly 
                965                 970                 975     


Cys Phe Glu Phe Ala Trp Ser Leu Asn Pro Met Ser Tyr Leu Glu Leu 
            980                 985                 990         


Val Lys Ser Asn Gly Glu Leu Ile  Glu Gly Tyr Phe Arg  Ser Met Asp 
        995                 1000                 1005             


Arg Thr  Thr Gly Ala Ile Asn  Leu Ser Pro Met Ser  Thr Asn Ser 
    1010                 1015                 1020             


Glu Thr  Ile Arg Ser Ile Gly  Val Lys Thr Leu Ser  Ser Phe Arg 
    1025                 1030                 1035             


Lys Phe  Thr Val Asp Arg Leu  Gly Arg Lys Phe Glu  Ile Pro Arg 
    1040                 1045                 1050             


Glu Val  Arg Thr Trp Arg Gly  Glu Ala Cys Thr 
    1055                 1060                 


<210> 409
<211> 1173
<212> PRT
<213> Rhodospirillum rubrum


<220>
<223> Rhodospirillum rubrum ATCC 11170

<400> 409
Met Arg Pro Ile Glu Pro Trp Ile Leu Gly Leu Asp Ile Gly Thr Asp 
1               5                   10                  15      


Ser Leu Gly Trp Ala Val Phe Ser Cys Glu Glu Lys Gly Pro Pro Thr 
            20                  25                  30          


Ala Lys Glu Leu Leu Gly Gly Gly Val Arg Leu Phe Asp Ser Gly Arg 
        35                  40                  45              


Asp Ala Lys Asp His Thr Ser Arg Gln Ala Glu Arg Gly Ala Phe Arg 
    50                  55                  60                  


Arg Ala Arg Arg Gln Thr Arg Thr Trp Pro Trp Arg Arg Asp Arg Leu 
65                  70                  75                  80  


Ile Ala Leu Phe Gln Ala Ala Gly Leu Thr Pro Pro Ala Ala Glu Thr 
                85                  90                  95      


Arg Gln Ile Ala Leu Ala Leu Arg Arg Glu Ala Val Ser Arg Pro Leu 
            100                 105                 110         


Ala Pro Asp Ala Leu Trp Ala Ala Leu Leu His Leu Ala His His Arg 
        115                 120                 125             


Gly Phe Arg Ser Asn Arg Ile Asp Lys Arg Glu Arg Ala Ala Ala Lys 
    130                 135                 140                 


Ala Leu Ala Lys Ala Lys Pro Ala Lys Ala Thr Ala Lys Ala Thr Ala 
145                 150                 155                 160 


Pro Ala Lys Glu Ala Asp Asp Glu Ala Gly Phe Trp Glu Gly Ala Glu 
                165                 170                 175     


Ala Ala Leu Arg Gln Arg Met Ala Ala Ser Gly Ala Pro Thr Val Gly 
            180                 185                 190         


Ala Leu Leu Ala Asp Asp Leu Asp Arg Gly Gln Pro Val Arg Met Arg 
        195                 200                 205             


Tyr Asn Gln Ser Asp Arg Asp Gly Val Val Ala Pro Thr Arg Ala Leu 
    210                 215                 220                 


Ile Ala Glu Glu Leu Ala Glu Ile Val Ala Arg Gln Ser Ser Ala Tyr 
225                 230                 235                 240 


Pro Gly Leu Asp Trp Pro Ala Val Thr Arg Leu Val Leu Asp Gln Arg 
                245                 250                 255     


Pro Leu Arg Ser Lys Gly Ala Gly Pro Cys Ala Phe Leu Pro Gly Glu 
            260                 265                 270         


Asp Arg Ala Leu Arg Ala Leu Pro Thr Val Gln Asp Phe Ile Ile Arg 
        275                 280                 285             


Gln Thr Leu Ala Asn Leu Arg Leu Pro Ser Thr Ser Ala Asp Glu Pro 
    290                 295                 300                 


Arg Pro Leu Thr Asp Glu Glu His Ala Lys Ala Leu Ala Leu Leu Ser 
305                 310                 315                 320 


Thr Ala Arg Phe Val Glu Trp Pro Ala Leu Arg Arg Ala Leu Gly Leu 
                325                 330                 335     


Lys Arg Gly Val Lys Phe Thr Ala Glu Thr Glu Arg Asn Gly Ala Lys 
            340                 345                 350         


Gln Ala Ala Arg Gly Thr Ala Gly Asn Leu Thr Glu Ala Ile Leu Ala 
        355                 360                 365             


Pro Leu Ile Pro Gly Trp Ser Gly Trp Asp Leu Asp Arg Lys Asp Arg 
    370                 375                 380                 


Val Phe Ser Asp Leu Trp Ala Ala Arg Gln Asp Arg Ser Ala Leu Leu 
385                 390                 395                 400 


Ala Leu Ile Gly Asp Pro Arg Gly Pro Thr Arg Val Thr Glu Asp Glu 
                405                 410                 415     


Thr Ala Glu Ala Val Ala Asp Ala Ile Gln Ile Val Leu Pro Thr Gly 
            420                 425                 430         


Arg Ala Ser Leu Ser Ala Lys Ala Ala Arg Ala Ile Ala Gln Ala Met 
        435                 440                 445             


Ala Pro Gly Ile Gly Tyr Asp Glu Ala Val Thr Leu Ala Leu Gly Leu 
    450                 455                 460                 


His His Ser His Arg Pro Arg Gln Glu Arg Leu Ala Arg Leu Pro Tyr 
465                 470                 475                 480 


Tyr Ala Ala Ala Leu Pro Asp Val Gly Leu Asp Gly Asp Pro Val Gly 
                485                 490                 495     


Pro Pro Pro Ala Glu Asp Asp Gly Ala Ala Ala Glu Ala Tyr Tyr Gly 
            500                 505                 510         


Arg Ile Gly Asn Ile Ser Val His Ile Ala Leu Asn Glu Thr Arg Lys 
        515                 520                 525             


Ile Val Asn Ala Leu Leu His Arg His Gly Pro Ile Leu Arg Leu Val 
    530                 535                 540                 


Met Val Glu Thr Thr Arg Glu Leu Lys Ala Gly Ala Asp Glu Arg Lys 
545                 550                 555                 560 


Arg Met Ile Ala Glu Gln Ala Glu Arg Glu Arg Glu Asn Ala Glu Ile 
                565                 570                 575     


Asp Val Glu Leu Arg Lys Ser Asp Arg Trp Met Ala Asn Ala Arg Glu 
            580                 585                 590         


Arg Arg Gln Arg Val Arg Leu Ala Arg Arg Gln Asn Asn Leu Cys Pro 
        595                 600                 605             


Tyr Thr Ser Thr Pro Ile Gly His Ala Asp Leu Leu Gly Asp Ala Tyr 
    610                 615                 620                 


Asp Ile Asp His Val Ile Pro Leu Ala Arg Gly Gly Arg Asp Ser Leu 
625                 630                 635                 640 


Asp Asn Met Val Leu Cys Gln Ser Asp Ala Asn Lys Thr Lys Gly Asp 
                645                 650                 655     


Lys Thr Pro Trp Glu Ala Phe His Asp Lys Pro Gly Trp Ile Ala Gln 
            660                 665                 670         


Arg Asp Asp Phe Leu Ala Arg Leu Asp Pro Gln Thr Ala Lys Ala Leu 
        675                 680                 685             


Ala Trp Arg Phe Ala Asp Asp Ala Gly Glu Arg Val Ala Arg Lys Ser 
    690                 695                 700                 


Ala Glu Asp Glu Asp Gln Gly Phe Leu Pro Arg Gln Leu Thr Asp Thr 
705                 710                 715                 720 


Gly Tyr Ile Ala Arg Val Ala Leu Arg Tyr Leu Ser Leu Val Thr Asn 
                725                 730                 735     


Glu Pro Asn Ala Val Val Ala Thr Asn Gly Arg Leu Thr Gly Leu Leu 
            740                 745                 750         


Arg Leu Ala Trp Asp Ile Thr Pro Gly Pro Ala Pro Arg Asp Leu Leu 
        755                 760                 765             


Pro Thr Pro Arg Asp Ala Leu Arg Asp Asp Thr Ala Ala Arg Arg Phe 
    770                 775                 780                 


Leu Asp Gly Leu Thr Pro Pro Pro Leu Ala Lys Ala Val Glu Gly Ala 
785                 790                 795                 800 


Val Gln Ala Arg Leu Ala Ala Leu Gly Arg Ser Arg Val Ala Asp Ala 
                805                 810                 815     


Gly Leu Ala Asp Ala Leu Gly Leu Thr Leu Ala Ser Leu Gly Gly Gly 
            820                 825                 830         


Gly Lys Asn Arg Ala Asp His Arg His His Phe Ile Asp Ala Ala Met 
        835                 840                 845             


Ile Ala Val Thr Thr Arg Gly Leu Ile Asn Gln Ile Asn Gln Ala Ser 
    850                 855                 860                 


Gly Ala Gly Arg Ile Leu Asp Leu Arg Lys Trp Pro Arg Thr Asn Phe 
865                 870                 875                 880 


Glu Pro Pro Tyr Pro Thr Phe Arg Ala Glu Val Met Lys Gln Trp Asp 
                885                 890                 895     


His Ile His Pro Ser Ile Arg Pro Ala His Arg Asp Gly Gly Ser Leu 
            900                 905                 910         


His Ala Ala Thr Val Phe Gly Val Arg Asn Arg Pro Asp Ala Arg Val 
        915                 920                 925             


Leu Val Gln Arg Lys Pro Val Glu Lys Leu Phe Leu Asp Ala Asn Ala 
    930                 935                 940                 


Lys Pro Leu Pro Ala Asp Lys Ile Ala Glu Ile Ile Asp Gly Phe Ala 
945                 950                 955                 960 


Ser Pro Arg Met Ala Lys Arg Phe Lys Ala Leu Leu Ala Arg Tyr Gln 
                965                 970                 975     


Ala Ala His Pro Glu Val Pro Pro Ala Leu Ala Ala Leu Ala Val Ala 
            980                 985                 990         


Arg Asp Pro Ala Phe Gly Pro Arg  Gly Met Thr Ala Asn  Thr Val Ile 
        995                 1000                 1005             


Ala Gly  Arg Ser Asp Gly Asp  Gly Glu Asp Ala Gly  Leu Ile Thr 
    1010                 1015                 1020             


Pro Phe  Arg Ala Asn Pro Lys  Ala Ala Val Arg Thr  Met Gly Asn 
    1025                 1030                 1035             


Ala Val  Tyr Glu Val Trp Glu  Ile Gln Val Lys Gly  Arg Pro Arg 
    1040                 1045                 1050             


Trp Thr  His Arg Val Leu Thr  Arg Phe Asp Arg Thr  Gln Pro Ala 
    1055                 1060                 1065             


Pro Pro  Pro Pro Pro Glu Asn  Ala Arg Leu Val Met  Arg Leu Arg 
    1070                 1075                 1080             


Arg Gly  Asp Leu Val Tyr Trp  Pro Leu Glu Ser Gly  Asp Arg Leu 
    1085                 1090                 1095             


Phe Leu  Val Lys Lys Met Ala  Val Asp Gly Arg Leu  Ala Leu Trp 
    1100                 1105                 1110             


Pro Ala  Arg Leu Ala Thr Gly  Lys Ala Thr Ala Leu  Tyr Ala Gln 
    1115                 1120                 1125             


Leu Ser  Cys Pro Asn Ile Asn  Leu Asn Gly Asp Gln  Gly Tyr Cys 
    1130                 1135                 1140             


Val Gln  Ser Ala Glu Gly Ile  Arg Lys Glu Lys Ile  Arg Thr Thr 
    1145                 1150                 1155             


Ser Cys  Thr Ala Leu Gly Arg  Leu Arg Leu Ser Lys  Lys Ala Thr 
    1160                 1165                 1170             


<210> 410
<211> 1059
<212> PRT
<213> Rhodovulum sp.


<220>
<223> Rhodovulum sp. PH10

<400> 410
Met Gly Ile Arg Phe Ala Phe Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Val Trp Arg Thr Gly Pro Gly Val Phe Gly Glu Asp Thr Ala Ala 
            20                  25                  30          


Ser Leu Asp Gly Ser Gly Val Leu Ile Phe Lys Asp Gly Arg Asn Pro 
        35                  40                  45              


Lys Asp Gly Gln Ser Leu Ala Thr Met Arg Arg Val Pro Arg Gln Ser 
    50                  55                  60                  


Arg Lys Arg Arg Asp Arg Phe Val Leu Arg Arg Arg Asp Leu Leu Ala 
65                  70                  75                  80  


Ala Leu Arg Lys Ala Gly Leu Phe Pro Val Asp Val Glu Glu Gly Arg 
                85                  90                  95      


Arg Leu Ala Ala Thr Asp Pro Tyr His Leu Arg Ala Lys Ala Leu Asp 
            100                 105                 110         


Glu Ser Leu Thr Pro His Glu Met Gly Arg Val Ile Phe His Leu Asn 
        115                 120                 125             


Gln Arg Arg Gly Phe Arg Ser Asn Arg Lys Ala Asp Arg Gln Asp Arg 
    130                 135                 140                 


Glu Lys Gly Lys Ile Ala Glu Gly Ser Lys Arg Leu Ala Glu Thr Leu 
145                 150                 155                 160 


Ala Ala Thr Asn Cys Arg Thr Leu Gly Glu Phe Leu Trp Ser Arg His 
                165                 170                 175     


Arg Gly Thr Pro Arg Thr Arg Ser Pro Thr Arg Ile Arg Met Glu Gly 
            180                 185                 190         


Glu Gly Ala Lys Ala Leu Tyr Ala Phe Tyr Pro Thr Arg Glu Met Val 
        195                 200                 205             


Arg Ala Glu Phe Glu Arg Leu Trp Thr Ala Gln Ser Arg Phe Ala Pro 
    210                 215                 220                 


Asp Leu Leu Thr Pro Glu Arg His Glu Glu Ile Ala Gly Ile Leu Phe 
225                 230                 235                 240 


Arg Gln Arg Asp Leu Ala Pro Pro Lys Ile Gly Cys Cys Thr Phe Glu 
                245                 250                 255     


Pro Ser Glu Arg Arg Leu Pro Arg Ala Leu Pro Ser Val Glu Ala Arg 
            260                 265                 270         


Gly Ile Tyr Glu Arg Leu Ala His Leu Arg Ile Thr Thr Gly Pro Val 
        275                 280                 285             


Ser Asp Arg Gly Leu Thr Arg Pro Glu Arg Asp Val Leu Ala Ser Ala 
    290                 295                 300                 


Leu Leu Ala Gly Lys Ser Leu Thr Phe Lys Ala Val Arg Lys Thr Leu 
305                 310                 315                 320 


Lys Ile Leu Pro His Ala Leu Val Asn Phe Glu Glu Ala Gly Glu Lys 
                325                 330                 335     


Gly Leu Asp Gly Ala Leu Thr Ala Lys Leu Leu Ser Lys Pro Asp His 
            340                 345                 350         


Tyr Gly Ala Ala Trp His Gly Leu Ser Phe Ala Glu Lys Asp Thr Phe 
        355                 360                 365             


Val Gly Lys Leu Leu Asp Glu Ala Asp Glu Glu Arg Leu Ile Arg Arg 
    370                 375                 380                 


Leu Val Thr Glu Asn Arg Leu Ser Glu Asp Ala Ala Arg Arg Cys Ala 
385                 390                 395                 400 


Ser Ile Pro Leu Ala Asp Gly Tyr Gly Arg Leu Gly Arg Thr Ala Asn 
                405                 410                 415     


Thr Glu Ile Leu Ala Ala Leu Val Glu Glu Thr Asp Glu Thr Gly Thr 
            420                 425                 430         


Val Val Thr Tyr Ala Glu Ala Val Arg Arg Ala Gly Glu Arg Thr Gly 
        435                 440                 445             


Arg Asn Trp His His Ser Asp Glu Arg Asp Gly Val Ile Leu Asp Arg 
    450                 455                 460                 


Leu Pro Tyr Tyr Gly Glu Ile Leu Gln Arg His Val Val Pro Gly Ser 
465                 470                 475                 480 


Gly Glu Pro Glu Glu Lys Asn Glu Ala Ala Arg Trp Gly Arg Leu Ala 
                485                 490                 495     


Asn Pro Thr Val His Ile Gly Leu Asn Gln Leu Arg Lys Val Val Asn 
            500                 505                 510         


Arg Leu Ile Ala Ala His Gly Arg Pro Asp Gln Ile Val Val Glu Leu 
        515                 520                 525             


Ala Arg Glu Leu Lys Leu Asn Arg Glu Gln Lys Glu Arg Leu Asp Arg 
    530                 535                 540                 


Glu Asn Arg Lys Asn Arg Glu Glu Asn Glu Arg Arg Thr Ala Ile Leu 
545                 550                 555                 560 


Ala Glu His Gly Gln Arg Asp Thr Ala Glu Asn Lys Ile Arg Leu Arg 
                565                 570                 575     


Leu Phe Glu Glu Gln Ala Arg Ala Asn Ala Gly Ile Ala Leu Cys Pro 
            580                 585                 590         


Tyr Thr Gly Arg Ala Ile Gly Ile Ala Glu Leu Phe Thr Ser Glu Val 
        595                 600                 605             


Glu Ile Asp His Ile Leu Pro Val Ser Leu Thr Leu Asp Asp Ser Leu 
    610                 615                 620                 


Ala Asn Arg Val Leu Cys Arg Arg Glu Ala Asn Arg Glu Lys Arg Arg 
625                 630                 635                 640 


Gln Thr Pro Phe Gln Ala Phe Gly Ala Thr Pro Ala Trp Asn Asp Ile 
                645                 650                 655     


Val Ala Arg Ala Ala Lys Leu Pro Pro Asn Lys Arg Trp Arg Phe Asp 
            660                 665                 670         


Pro Ala Ala Leu Glu Arg Phe Glu Arg Glu Gly Gly Phe Leu Gly Arg 
        675                 680                 685             


Gln Leu Asn Glu Thr Lys Tyr Leu Ser Arg Leu Ala Lys Ile Tyr Leu 
    690                 695                 700                 


Gly Lys Ile Cys Asp Pro Asp Arg Val Tyr Val Thr Pro Gly Thr Leu 
705                 710                 715                 720 


Thr Gly Leu Leu Arg Ala Arg Trp Gly Leu Asn Ser Ile Leu Ser Asp 
                725                 730                 735     


Ser Asn Phe Lys Asn Arg Ser Asp His Arg His His Ala Val Asp Ala 
            740                 745                 750         


Val Val Ile Gly Val Leu Thr Arg Gly Met Ile Gln Arg Ile Ala His 
        755                 760                 765             


Asp Ala Ala Arg Ala Glu Asp Gln Asp Leu Asp Arg Val Phe Arg Asp 
    770                 775                 780                 


Val Pro Val Pro Phe Glu Asp Phe Arg Asp His Val Arg Glu Arg Val 
785                 790                 795                 800 


Ser Thr Ile Thr Val Ala Val Lys Pro Glu His Gly Lys Gly Gly Ala 
                805                 810                 815     


Leu His Glu Asp Thr Ser Tyr Gly Leu Val Pro Asp Thr Asp Pro Asn 
            820                 825                 830         


Ala Ala Leu Gly Asn Leu Val Val Arg Lys Pro Ile Arg Ser Leu Thr 
        835                 840                 845             


Ala Gly Glu Val Asp Arg Val Arg Asp Arg Ala Leu Arg Ala Arg Leu 
    850                 855                 860                 


Gly Ala Leu Ala Ala Pro Phe Arg Asp Glu Ser Gly Arg Val Arg Asp 
865                 870                 875                 880 


Ala Lys Gly Leu Ala Gln Ala Leu Glu Ala Phe Gly Ala Glu Asn Gly 
                885                 890                 895     


Ile Arg Arg Val Arg Ile Leu Lys Pro Asp Ala Ser Val Val Thr Ile 
            900                 905                 910         


Ala Asp Arg Arg Thr Gly Val Pro Tyr Arg Ala Val Ala Pro Gly Glu 
        915                 920                 925             


Asn His His Val Asp Ile Val Gln Met Arg Asp Gly Ser Trp Arg Gly 
    930                 935                 940                 


Phe Ala Ala Ser Val Phe Glu Val Asn Arg Pro Gly Trp Arg Pro Glu 
945                 950                 955                 960 


Trp Glu Val Lys Lys Leu Gly Gly Lys Leu Val Met Arg Leu His Lys 
                965                 970                 975     


Gly Asp Met Val Glu Leu Ser Asp Lys Asp Gly Gln Arg Arg Val Lys 
            980                 985                 990         


Val Val Gln Gln Ile Glu Ile Ser  Ala Asn Arg Val Arg  Leu Ser Pro 
        995                 1000                 1005             


His Asn  Asp Gly Gly Lys Leu  Gln Asp Arg His Ala  Asp Ala Asp 
    1010                 1015                 1020             


Asp Pro  Phe Arg Trp Asp Leu  Ala Thr Ile Pro Leu  Leu Lys Asp 
    1025                 1030                 1035             


Arg Gly  Cys Val Ala Val Arg  Val Asp Pro Ile Gly  Val Val Thr 
    1040                 1045                 1050             


Leu Arg  Arg Ser Asn Val 
    1055                 


<210> 411
<211> 1405
<212> PRT
<213> Riemerella anatipestifer

<400> 411
Met Lys Thr Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Lys Glu Ala Glu Asn Ser Asn Glu Lys Ser Glu Ile Ile 
            20                  25                  30          


Lys Leu Gly Val Arg Val Asn Pro Leu Thr Val Asp Glu Lys Thr Asn 
        35                  40                  45              


Phe Glu Ala Gly Arg Pro Leu Ser Thr Asn Ala Asp Arg Thr Ala Lys 
    50                  55                  60                  


Arg Ser Ala Arg Arg Asn Leu Gln Arg Tyr Lys Leu Arg Arg Lys Asn 
65                  70                  75                  80  


Leu Ile Asp Leu Leu Ile Lys Asn Gln Leu Ile Asp Lys Asp Thr Pro 
                85                  90                  95      


Leu Thr Glu Ile Gly Lys Asn Thr Thr His Gln Thr Leu Glu Leu Arg 
            100                 105                 110         


Ala Lys Ala Ala Arg Glu Arg Ile Glu Leu Glu Asp Leu Ala Arg Val 
        115                 120                 125             


Phe Leu Ala Ile Asn Lys Lys Arg Gly Tyr Arg Ser Ser Arg Lys Val 
    130                 135                 140                 


Asn Asn Glu Glu Glu Gly Gln Ala Val Asp Gly Met Ala Val Ala Lys 
145                 150                 155                 160 


Lys Leu Tyr Asp Glu Asn Leu Thr Pro Gly Gln Tyr Ala Tyr Glu Leu 
                165                 170                 175     


Leu Ser Lys Gly Lys Lys Tyr Val Pro Asp Phe Tyr Arg Ser Asp Leu 
            180                 185                 190         


Gln Ala Glu Phe Asn Ala Ile Trp Glu Tyr Gln Lys Gln Phe Tyr Ala 
        195                 200                 205             


Asp Ile Leu Asp Asp Glu Leu Tyr Asn Ala Leu Lys Gly Gln Gly Gln 
    210                 215                 220                 


Gln Asn Ser Arg Lys Arg Phe Leu Ala Ile Lys Gly Val Tyr Thr Ala 
225                 230                 235                 240 


Glu Asn Lys Gly Lys Arg Asp Asp Val Lys Leu Arg His Tyr Lys Trp 
                245                 250                 255     


Arg Ser Glu Ala Ile Ser Lys Lys Ile Asn Ile Glu Glu Val Ala Tyr 
            260                 265                 270         


Val Leu Val Glu Ile Asn Asn Asp Leu Asn Lys Ser Ser Gly Tyr Leu 
        275                 280                 285             


Gly Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Lys Glu Thr 
    290                 295                 300                 


Val Gly Glu Asn Leu Trp Lys Gln Ile Gln Lys Asn Pro His Thr Ser 
305                 310                 315                 320 


Leu Lys Asn Gln Val Phe Tyr Arg Gln Asp Tyr Leu Asp Glu Phe Glu 
                325                 330                 335     


Gln Ile Trp Glu Thr Gln Ala Gln Phe His Pro Gln Leu Thr Leu Ala 
            340                 345                 350         


Leu Lys Glu Gln Ile Arg Asp Val Ile Ile Phe Tyr Gln Arg Lys Leu 
        355                 360                 365             


Lys Ser Gln Lys Gly Leu Leu Ser Phe Cys Gln Phe Glu Ser Trp Glu 
    370                 375                 380                 


Ile Glu Arg Lys Asp Glu Asn Gly Asn Val Ile Leu Asn Lys Thr Thr 
385                 390                 395                 400 


Gln Leu Pro Lys Arg Gln Thr Val Gly Arg Arg Val Ala Pro Lys Ser 
                405                 410                 415     


Ser Pro Leu Phe Gln Glu Phe Lys Ile Trp Gln Asn Ile Asn Asn Leu 
            420                 425                 430         


Glu Val Thr Lys Ile Ser Glu Gly Ala Ser Lys Asn Lys Lys Glu Thr 
        435                 440                 445             


Glu Thr Leu Ser Asp Asp Glu Arg Lys Leu Leu Phe Glu Glu Leu Asn 
    450                 455                 460                 


Leu Arg Gly Asn Leu Ser Gln Lys Glu Val Leu Gln Ile Leu Gly Leu 
465                 470                 475                 480 


Lys Asp Lys Glu Tyr Lys Thr Asn Phe Ser Glu Gly Leu Glu Gly Asn 
                485                 490                 495     


Arg Thr Asn Ala Ala Leu Phe Asn Ile Tyr Gln Gln Ile Ala Glu Asn 
            500                 505                 510         


Glu Gly Tyr Gly Phe Asp Trp Ser Lys Lys Ser Ala Gln Glu Ile Lys 
        515                 520                 525             


Glu Glu Leu Lys Ala Val Phe Pro Gln Ile Gly Ile Gln Ala Asp Ile 
    530                 535                 540                 


Leu Asp Phe Asn Ala Asn Leu Asp Gly Lys Glu Phe Glu Asn Gln Ala 
545                 550                 555                 560 


Ser Tyr Gln Leu Trp His Leu Leu Tyr Ser Ala Glu Glu Asp Asp Lys 
                565                 570                 575     


Ile Asn Glu Glu Asp Gln Ile Ile Tyr Gly Asn Ser Ala Val Ser Leu 
            580                 585                 590         


Lys Lys Lys Leu Cys Glu Lys Phe Gly Phe Thr Pro Glu Tyr Ala Lys 
        595                 600                 605             


Trp Ile Ala Asn Val Ser Leu Gln Asp Asp Tyr Gly Asn Leu Ser Thr 
    610                 615                 620                 


Lys Ala Met Arg Lys Ile Ile Pro Tyr Leu Ile Asp Gly Asn Asp Tyr 
625                 630                 635                 640 


Ser Glu Ala Cys Ala Leu Ala Gly Tyr Asn His Ser Asn Ser Leu Thr 
                645                 650                 655     


Lys Glu Glu Asn Asp Asn Arg Glu Leu Leu Asp Lys Leu Glu Leu Leu 
            660                 665                 670         


Pro Lys Asn Ser Leu Arg Asn Pro Val Val Glu Lys Ile Leu Asn Gln 
        675                 680                 685             


Met Val Asn Val Val Asn Gln Val Ile Glu Thr Tyr Gly Lys Pro Asp 
    690                 695                 700                 


Glu Val Arg Ile Glu Leu Ala Arg Glu Leu Lys Lys Ser Ala Glu Lys 
705                 710                 715                 720 


Arg Ala Glu Met Thr Lys Ser Ile Asn Glu Ala Thr Arg Arg Asn Glu 
                725                 730                 735     


Asp Ile Lys Lys Leu Ile Thr Lys Asp Phe Gly Ile Pro Asn Pro Thr 
            740                 745                 750         


Lys Ser Asp Val Val Arg Tyr Arg Leu Trp Glu Glu Leu Ala Pro Leu 
        755                 760                 765             


Ala Tyr Lys Asp Val Phe Thr Gly Lys Gln Ile Lys Lys Glu Asp Leu 
    770                 775                 780                 


Phe Ser Ser Lys Ile Asp Ile Glu His Ile Ile Pro Lys Ala Leu Leu 
785                 790                 795                 800 


Phe Asp Asp Ser Phe Ser Asn Lys Thr Leu Val Phe Arg Glu Thr Asn 
                805                 810                 815     


Leu Lys Lys Ala Asp Arg Thr Ala Tyr Asp Phe Ile Glu Ser Asp Tyr 
            820                 825                 830         


Asn Ala Thr Leu Asp Asp Tyr Ile Gln Arg Val Glu Thr Leu Tyr Asn 
        835                 840                 845             


Asn Thr Lys Gly Thr Ile Ser Lys Gly Lys Arg Asn Lys Leu Leu Met 
    850                 855                 860                 


Ala Gln Lys Asn Leu Pro Asp Gly Phe Ile Glu Arg Asp Leu Arg Asn 
865                 870                 875                 880 


Ser Gln Tyr Ile Ala Lys Lys Ala Lys Ala Met Leu Tyr Gln Val Phe 
                885                 890                 895     


Lys Asp Val Asn Val Thr Ser Gly Ser Ile Thr Asp Arg Leu Arg Glu 
            900                 905                 910         


Asp Trp Asp Leu Ile Asn Val Met Lys Glu Leu Asn Phe Pro Lys Tyr 
        915                 920                 925             


Lys Ala Leu Gly Leu Thr Glu Ile Glu Glu Arg Tyr Asp Ile Gly Gln 
    930                 935                 940                 


Glu Lys Thr Lys Arg Val Glu Val Ile Thr Asp Trp Thr Lys Arg Asn 
945                 950                 955                 960 


Asp His Arg His His Ala Met Asn Ala Leu Thr Val Ala Phe Thr Thr 
                965                 970                 975     


Ser Ser His Ile Gln Tyr Leu Asn Tyr Leu Asn Ala Arg Lys Asn Glu 
            980                 985                 990         


Ser His Lys Glu His Lys Asn Ile  Lys Gly Ile Glu Asn  Lys Ile Thr 
        995                 1000                 1005             


His Lys  Gln Lys Asp Lys Arg  Lys Phe Ile Pro Pro  Met Pro Asn 
    1010                 1015                 1020             


Phe Arg  Glu Glu Ala Lys Lys  His Ile Glu Thr Ile  Leu Val Ser 
    1025                 1030                 1035             


Ile Lys  Asn Lys Asn Lys Val  Tyr Thr Lys Asn Ile  Asn Lys Thr 
    1040                 1045                 1050             


Lys Lys  Lys Ser Gly His Asn  Thr Lys Glu Gln Leu  Thr Pro Arg 
    1055                 1060                 1065             


Gly Gln  Leu His Lys Glu Thr  Val Tyr Gly Lys Ser  Lys Arg Pro 
    1070                 1075                 1080             


Met Ser  Lys Pro Thr Lys Ile  Asn Lys Asn Phe Ser  Leu Glu Gln 
    1085                 1090                 1095             


Ala Gln  Leu Ile Ile Asn Val  Gln Glu Lys Glu Leu  Val Leu Arg 
    1100                 1105                 1110             


His Leu  Ala Gln Phe Asp Asn  Asn Pro Ala Val Ala  Phe Asp Thr 
    1115                 1120                 1125             


Lys Thr  Leu Lys Lys Met Pro  Leu Leu Lys Asn Gly  Glu Pro Leu 
    1130                 1135                 1140             


Lys Glu  Val Leu Cys Phe Glu  Glu Ile Phe Thr Ile  Arg Lys Asp 
    1145                 1150                 1155             


Ile Thr  Pro Asp Leu Lys Ile  Glu Lys Val Val Asp  Glu Lys Ile 
    1160                 1165                 1170             


Lys Ala  Ile Leu Glu Gln Arg  Lys Lys Asp Phe Gly  Gly Asn Ala 
    1175                 1180                 1185             


Lys Glu  Ala Phe Ser Asp Leu  Asp Lys Asn Pro Ile  Trp Leu Asn 
    1190                 1195                 1200             


Lys Lys  Lys Gly Ile Cys Ile  Lys Arg Val Thr Ile  Thr Gly Val 
    1205                 1210                 1215             


Ser Asn  Ala Glu Ala Leu His  His Gln Lys Asp His  Leu Gly Arg 
    1220                 1225                 1230             


Glu Ile  Leu Asp Asp Asn Gly  Asn Pro Ile Pro Ala  Asp Phe Val 
    1235                 1240                 1245             


Ser Thr  Gly Asn Asn His His  Leu Ala Val Tyr Leu  Asp Ser Glu 
    1250                 1255                 1260             


Gly Lys  Leu Gln Asp Asn Ile  Val Ser Phe Tyr Glu  Ala Val Val 
    1265                 1270                 1275             


Arg Thr  Ser Gln Gly Leu Pro  Val Val Asp Lys Gly  Leu Asn Lys 
    1280                 1285                 1290             


Asp Leu  Gly Trp Lys Phe Leu  Phe Ser Leu Lys Gln  Asn Glu Met 
    1295                 1300                 1305             


Phe Val  Phe Pro Asn Asp Asp  Phe Asp Ile Asn Asp  Phe Asp Leu 
    1310                 1315                 1320             


Leu Asp  Asp Lys Lys Ala Glu  Leu Ile Ser Lys His  Leu Tyr Arg 
    1325                 1330                 1335             


Val Gln  Lys Ile Ser Lys Val  Ser Ala Gly Asn Ser  Phe Val Arg 
    1340                 1345                 1350             


Asp Ile  Val Phe Arg His His  Leu Glu Thr Thr Val  Lys Glu Val 
    1355                 1360                 1365             


Lys Glu  Leu Lys Asp Ile Ser  Tyr Ile Gln Leu Lys  Ser Leu Glu 
    1370                 1375                 1380             


Gly Leu  Arg Asn Ile Lys Lys  Val Arg Ile Asn His  Ile Gly Lys 
    1385                 1390                 1395             


Ile Val  Gln Val Gly Glu Tyr  
    1400                 1405 


<210> 412
<211> 1400
<212> PRT
<213> Riemerella anatipestifer

<400> 412
Met Lys Thr Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Lys Glu Thr Glu Asn Ser Asn Glu Lys Ser Glu Ile Ile 
            20                  25                  30          


Lys Leu Gly Val Arg Val Asn Pro Leu Thr Val Asp Glu Lys Thr Asn 
        35                  40                  45              


Phe Glu Ala Gly Arg Pro Leu Ser Thr Asn Ala Asp Arg Thr Ala Lys 
    50                  55                  60                  


Arg Ser Ala Arg Arg Asn Leu Gln Arg Tyr Lys Leu Arg Arg Lys Asn 
65                  70                  75                  80  


Leu Ile Asp Leu Leu Ile Lys His Arg Leu Ile Asp Lys Asp Thr Pro 
                85                  90                  95      


Leu Thr Glu Ile Gly Lys Asn Thr Thr His Gln Thr Leu Glu Leu Arg 
            100                 105                 110         


Ala Lys Ala Ala Arg Glu Arg Ile Glu Leu Glu Asp Leu Ala Arg Val 
        115                 120                 125             


Phe Leu Ala Ile Asn Lys Lys Arg Gly Tyr Arg Ser Ser Arg Lys Val 
    130                 135                 140                 


Asn Asn Glu Glu Glu Gly Gln Val Val Asp Gly Met Ala Val Ala Lys 
145                 150                 155                 160 


Lys Leu Tyr Asp Glu Asn Leu Thr Pro Gly Gln Tyr Ala Tyr Glu Leu 
                165                 170                 175     


Leu Ser Lys Gly Lys Lys Tyr Val Pro Asp Phe Tyr Arg Ser Asp Leu 
            180                 185                 190         


Gln Ala Glu Phe Asp Ser Ile Trp Glu Tyr Gln Lys Gln Phe Tyr Ala 
        195                 200                 205             


Asp Ile Leu Asp Asp Glu Leu Tyr Asn Ala Leu Lys Gly Gln Gly Gln 
    210                 215                 220                 


Gln Asn Ser Arg Lys Arg Phe Leu Ala Ile Lys Gly Val Tyr Thr Ala 
225                 230                 235                 240 


Glu Asn Lys Gly Lys Arg Asp Glu Val Lys Leu Gln His Tyr Lys Trp 
                245                 250                 255     


Arg Ser Glu Ala Ile Thr Gln Lys Leu Ser Ile Glu Glu Val Ala Tyr 
            260                 265                 270         


Val Leu Val Glu Ile Asn Asn Asp Leu Asn Lys Ser Ser Gly Tyr Leu 
        275                 280                 285             


Gly Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Lys Glu Thr 
    290                 295                 300                 


Val Gly Glu Asn Leu Trp Lys Gln Ile Gln Lys Asn Pro His Thr Ser 
305                 310                 315                 320 


Leu Lys Asn Gln Val Phe Tyr Arg Gln Asp Tyr Leu Asp Glu Phe Glu 
                325                 330                 335     


Gln Ile Trp Glu Thr Gln Ala Gln Phe His Pro Gln Leu Thr Leu Ala 
            340                 345                 350         


Leu Lys Glu Gln Ile Arg Asp Val Val Ile Phe Tyr Gln Arg Lys Leu 
        355                 360                 365             


Lys Ser Gln Lys Gly Leu Leu Ser Phe Cys Gln Phe Glu Ser Trp Glu 
    370                 375                 380                 


Ile Glu Arg Lys Asp Glu Asn Gly Asn Val Ile Leu Asn Lys Thr Thr 
385                 390                 395                 400 


Gln Leu Pro Lys Arg Gln Thr Val Gly Arg Arg Val Ala Pro Lys Ser 
                405                 410                 415     


Ser Pro Leu Phe Gln Glu Phe Lys Ile Trp Gln Asn Ile Asn Asn Leu 
            420                 425                 430         


Glu Ile Ala Lys Ile Ser Asp Gly Asn Ser Lys Asn Lys Lys Glu Thr 
        435                 440                 445             


Glu Ala Leu Ser Asp Asp Glu Arg Lys Leu Leu Phe Glu Glu Leu Asn 
    450                 455                 460                 


Leu Arg Gly Asn Leu Ser Gln Lys Glu Val Leu Gln Ile Leu Gly Leu 
465                 470                 475                 480 


Lys Asp Lys Glu Tyr Lys Thr Asn Phe Pro Glu Gly Leu Glu Gly Asn 
                485                 490                 495     


Arg Thr Asn Ala Ala Leu Phe Asn Ile Tyr Gln Gln Ile Ala Glu Asn 
            500                 505                 510         


Glu Gly Tyr Gly Asp Trp Thr Lys Lys Ser Ala Gln Glu Ile Lys Glu 
        515                 520                 525             


Glu Leu Lys Ala Val Phe Pro Gln Ile Gly Ile Gln Ala Asp Ile Leu 
    530                 535                 540                 


Asp Phe Asn Ala Glu Leu Asp Gly Lys Glu Phe Glu Asn Gln Ala Ser 
545                 550                 555                 560 


Tyr Gln Leu Trp His Leu Leu Tyr Ser Ala Glu Glu Asp Asp Lys Ile 
                565                 570                 575     


Asn Glu Glu Asp Gln Ile Ile Tyr Gly Asn Ser Ala Val Ser Leu Lys 
            580                 585                 590         


Lys Lys Leu Cys Glu Lys Phe Gly Phe Thr Pro Glu Tyr Ala Lys Trp 
        595                 600                 605             


Ile Ala Asn Val Ser Leu Gln Asp Asp Tyr Gly Asn Leu Ser Thr Lys 
    610                 615                 620                 


Ala Met Arg Lys Ile Ile Pro Tyr Leu Ile Asp Gly Asn Asp Tyr Ser 
625                 630                 635                 640 


Glu Ala Cys Ala Leu Ala Gly Tyr Asn His Ser Asn Ser Leu Thr Lys 
                645                 650                 655     


Glu Glu Asn Asp Asn Arg Glu Arg Leu Asn Lys Leu Glu Leu Leu Pro 
            660                 665                 670         


Lys Asn Ser Leu Arg Asn Pro Val Val Glu Lys Ile Leu Asn Gln Met 
        675                 680                 685             


Val Asn Val Val Asn Gln Val Ile Glu Thr Tyr Gly Lys Pro Asp Glu 
    690                 695                 700                 


Val Arg Ile Glu Leu Ala Arg Glu Leu Lys Lys Ser Ala Glu Glu Arg 
705                 710                 715                 720 


Ala Glu Met Thr Lys Gly Ile Asn Glu Ala Thr Arg Arg Asn Glu Asp 
                725                 730                 735     


Ile Lys Lys Leu Ile Thr Lys Asn Phe Gly Ile Pro Asn Pro Thr Lys 
            740                 745                 750         


Asn Asp Val Val Arg Tyr Arg Leu Trp Glu Glu Leu Ala Pro Leu Ala 
        755                 760                 765             


Tyr Lys Asp Val Phe Thr Gly Arg Gln Ile Lys Lys Glu Asp Leu Phe 
    770                 775                 780                 


Ser Ser Lys Ile Asp Ile Glu His Ile Ile Pro Lys Ala Leu Leu Phe 
785                 790                 795                 800 


Asp Asp Ser Phe Ser Asn Lys Thr Leu Ala Phe Arg Glu Thr Asn Leu 
                805                 810                 815     


Lys Lys Ala Asp Arg Thr Ala Tyr Gly Phe Ile Glu Ser Asp Tyr Asn 
            820                 825                 830         


Ala Thr Leu Asp Asp Tyr Ile Gln Arg Val Glu Thr Leu Tyr Asn Asn 
        835                 840                 845             


Ala Lys Gly Thr Ile Ser Lys Gly Lys Arg Asn Lys Leu Leu Met Ala 
    850                 855                 860                 


Gln Lys Asn Leu Pro Asp Gly Phe Ile Glu Arg Asp Leu Arg Asn Ser 
865                 870                 875                 880 


Gln Tyr Ile Ala Lys Lys Ala Lys Ser Met Ile Glu Lys Val Phe Asn 
                885                 890                 895     


Asp Val Asn Val Thr Ser Gly Ser Ile Thr Asp Arg Leu Arg Glu Asp 
            900                 905                 910         


Trp Asp Leu Ile Asn Val Met Lys Glu Leu Asn Phe Pro Lys Tyr Lys 
        915                 920                 925             


Ala Leu Gly Leu Thr Glu Ile Glu Glu Arg Tyr Asp Ile Gly Gln Glu 
    930                 935                 940                 


Lys Thr Lys Lys Val Glu Val Ile Thr Asp Trp Thr Lys Arg Asn Asp 
945                 950                 955                 960 


His Arg His His Ala Met Asp Ala Leu Thr Val Ala Phe Thr Thr Lys 
                965                 970                 975     


Ser His Val Gln Tyr Leu Asn Asn Leu Asn Thr Ile His Ser Leu Lys 
            980                 985                 990         


Gly Asp Glu Val Asp Leu Glu Leu  Ser Lys Leu Tyr Gly  Leu Lys Asn 
        995                 1000                 1005             


Thr Ile  Thr Glu Val Val Asn  Lys Lys Arg Lys Phe  Ile Pro Pro 
    1010                 1015                 1020             


Met Pro  Asn Phe Arg Glu Glu  Ala Lys Lys His Ile  Glu Thr Ile 
    1025                 1030                 1035             


Leu Val  Ser Ile Lys Asn Lys  Asn Lys Val Tyr Thr  Lys Asn Ile 
    1040                 1045                 1050             


Asn Lys  Thr Lys Lys Glu Ser  Gly Tyr His Thr Lys  Glu Gln Leu 
    1055                 1060                 1065             


Thr Pro  Arg Gly Gln Leu His  Lys Glu Thr Val Tyr  Gly Lys Ser 
    1070                 1075                 1080             


Lys Arg  Pro Met Asn Lys Pro  Thr Lys Ile Asn Lys  Asn Phe Ser 
    1085                 1090                 1095             


Leu Glu  Gln Ala Gln Leu Ile  Ile Asn Val Gln Glu  Lys Glu Leu 
    1100                 1105                 1110             


Val Leu  Arg His Leu Ala Gln  Phe Asp Asn Asn Pro  Ala Val Ala 
    1115                 1120                 1125             


Phe Asp  Thr Lys Thr Leu Lys  Lys Met Pro Leu Leu  Lys Asn Gly 
    1130                 1135                 1140             


Glu Pro  Leu Lys Glu Val Leu  Cys Phe Glu Glu Ile  Phe Thr Ile 
    1145                 1150                 1155             


Arg Lys  Asp Ile Thr Pro Asp  Leu Lys Ile Glu Lys  Val Val Asp 
    1160                 1165                 1170             


Glu Lys  Ile Lys Ala Ile Leu  Glu Gln Arg Lys Lys  Asp Phe Gly 
    1175                 1180                 1185             


Gly Asn  Ala Lys Glu Ala Phe  Ser Asp Leu Asp Lys  Asn Pro Ile 
    1190                 1195                 1200             


Trp Leu  Asn Lys Glu Lys Gly  Ile Cys Ile Lys Arg  Val Thr Ile 
    1205                 1210                 1215             


Thr Gly  Val Ser Asn Ala Glu  Ala Leu His His Gln  Lys Asp His 
    1220                 1225                 1230             


Leu Gly  Arg Glu Ile Leu Asp  Asp Asn Gly Asn Pro  Ile Pro Ala 
    1235                 1240                 1245             


Asp Phe  Val Ser Thr Gly Asn  Asn His His Val Ala  Ile Tyr Glu 
    1250                 1255                 1260             


Asp Glu  Lys Gly Lys Leu Gln  Glu Lys Val Val Ser  Leu Tyr Glu 
    1265                 1270                 1275             


Ala Val  Ala Arg Ala Asn Gln  Gly Leu Pro Val Val  Asp Lys Gly 
    1280                 1285                 1290             


Leu Asn  Glu Asp Leu Gly Trp  Lys Phe Leu Phe Thr  Met Lys Gln 
    1295                 1300                 1305             


Asn Glu  Met Phe Val Phe Pro  Asn Asp Asp Phe Asp  Val Asn Asp 
    1310                 1315                 1320             


Ile Asp  Leu Leu Asp Glu Asn  Asn Ala Lys Ile Ile  Ser Gln His 
    1325                 1330                 1335             


Leu Phe  Arg Val Gln Lys Leu  Ala Thr Lys Asn Tyr  Met Phe Arg 
    1340                 1345                 1350             


His His  Leu Glu Thr Asn Val  Gln Glu Val Lys Glu  Leu Asn Asp 
    1355                 1360                 1365             


Ile Ala  Tyr Lys Ser Ile Arg  Ser Thr Glu Pro Leu  Lys Asn Ile 
    1370                 1375                 1380             


Lys Lys  Val Arg Ile Asn His  Ile Gly Lys Ile Val  Gln Val Gly 
    1385                 1390                 1395             


Glu Tyr  
    1400 


<210> 413
<211> 1140
<212> PRT
<213> Roseburia intestinalis


<220>
<223> Roseburia intestinalis L1-82

<400> 413
Met Arg Glu Asn Gly Ser Asp Glu Arg Arg Arg Asn Met Asp Glu Lys 
1               5                   10                  15      


Met Asp Tyr Arg Ile Gly Leu Asp Ile Gly Ile Ala Ser Val Gly Trp 
            20                  25                  30          


Ala Val Leu Gln Asn Asn Ser Asp Asp Glu Pro Val Arg Ile Val Asp 
        35                  40                  45              


Leu Gly Val Arg Ile Phe Asp Thr Ala Glu Ile Pro Lys Thr Gly Glu 
    50                  55                  60                  


Ser Leu Ala Gly Pro Arg Arg Ala Ala Arg Thr Thr Arg Arg Arg Leu 
65                  70                  75                  80  


Arg Arg Arg Lys His Arg Leu Asp Arg Ile Lys Trp Leu Phe Glu Asn 
                85                  90                  95      


Gln Gly Leu Ile Asn Ile Asp Asp Phe Leu Lys Arg Tyr Asn Met Ala 
            100                 105                 110         


Gly Leu Pro Asp Val Tyr Gln Leu Arg Tyr Glu Ala Leu Asp Arg Lys 
        115                 120                 125             


Leu Thr Asp Glu Glu Leu Ala Gln Val Leu Leu His Ile Ala Lys His 
    130                 135                 140                 


Arg Gly Phe Arg Ser Thr Arg Lys Ala Glu Thr Ala Ala Lys Glu Asn 
145                 150                 155                 160 


Gly Ala Val Leu Lys Ala Thr Asp Glu Asn Gln Lys Arg Met Gln Glu 
                165                 170                 175     


Lys Gly Tyr Arg Thr Val Gly Glu Met Ile Tyr Leu Asp Glu Ala Phe 
            180                 185                 190         


Arg Thr Gly Cys Ser Trp Ser Glu Lys Gly Tyr Ile Leu Thr Pro Arg 
        195                 200                 205             


Asn Lys Ala Glu Asn Tyr Gln His Thr Met Leu Arg Ala Met Leu Val 
    210                 215                 220                 


Glu Glu Val Lys Glu Ile Phe Ser Ser Gln Arg Arg Leu Gly Asn Glu 
225                 230                 235                 240 


Lys Ala Thr Glu Glu Leu Glu Glu Lys Tyr Leu Glu Ile Met Thr Ser 
                245                 250                 255     


Gln Arg Ser Phe Asp Leu Gly Pro Gly Met Gln Pro Asp Gly Lys Pro 
            260                 265                 270         


Ser Pro Tyr Ala Met Glu Gly Phe Ser Asp Arg Val Gly Lys Cys Thr 
        275                 280                 285             


Phe Leu Gly Asp Gln Gly Glu Leu Arg Gly Ala Lys Gly Thr Tyr Thr 
    290                 295                 300                 


Ala Glu Tyr Phe Val Ala Leu Gln Lys Ile Asn His Thr Lys Leu Val 
305                 310                 315                 320 


Asn Gln Asp Gly Glu Thr Arg Asn Phe Thr Glu Glu Glu Arg Arg Ala 
                325                 330                 335     


Leu Thr Leu Leu Leu Phe Thr Gln Lys Glu Val Lys Tyr Ala Ala Val 
            340                 345                 350         


Arg Lys Lys Leu Gly Leu Pro Glu Asp Ile Leu Phe Tyr Asn Leu Asn 
        355                 360                 365             


Tyr Lys Lys Ala Ala Thr Lys Glu Glu Gln Gln Lys Glu Asn Gln Asn 
    370                 375                 380                 


Thr Glu Lys Ala Lys Phe Ile Gly Met Pro Tyr Tyr His Asp Tyr Lys 
385                 390                 395                 400 


Lys Cys Leu Glu Glu Arg Val Lys Tyr Leu Thr Glu Asn Glu Val Arg 
                405                 410                 415     


Asp Leu Phe Asp Glu Ile Gly Met Ile Leu Thr Cys Tyr Lys Asn Asp 
            420                 425                 430         


Asp Ser Arg Thr Glu Arg Leu Ala Lys Leu Gly Leu Val Pro Ile Glu 
        435                 440                 445             


Met Glu Gly Leu Leu Ala Tyr Thr Pro Thr Lys Phe Gln His Leu Ser 
    450                 455                 460                 


Met Lys Ala Met Arg Asn Ile Ile Pro Phe Leu Glu Lys Gly Met Thr 
465                 470                 475                 480 


Tyr Asp Lys Ala Cys Glu Glu Ala Gly Tyr Asp Phe Lys Ala Asp Ser 
                485                 490                 495     


Lys Gly Thr Lys Gln Lys Leu Leu Thr Gly Glu Asn Val Asn Gln Thr 
            500                 505                 510         


Ile Asn Glu Ile Thr Asn Pro Val Val Lys Arg Ser Val Ser Gln Thr 
        515                 520                 525             


Val Lys Val Ile Asn Ala Ile Ile Arg Thr Tyr Gly Ser Pro Gln Ala 
    530                 535                 540                 


Ile Asn Ile Glu Leu Ala Arg Glu Met Ser Lys Thr Phe Glu Glu Arg 
545                 550                 555                 560 


Arg Lys Ile Lys Gly Asp Met Glu Lys Arg Gln Lys Asn Asn Glu Asp 
                565                 570                 575     


Val Lys Lys Gln Ile Gln Glu Leu Gly Lys Leu Ser Pro Thr Gly Gln 
            580                 585                 590         


Asp Ile Leu Lys Tyr Arg Leu Trp Gln Glu Gln Gln Gly Ile Cys Met 
        595                 600                 605             


Tyr Ser Gly Lys Thr Ile Pro Leu Glu Glu Leu Phe Lys Pro Gly Tyr 
    610                 615                 620                 


Asp Ile Asp His Ile Leu Pro Tyr Ser Ile Thr Phe Asp Asp Ser Phe 
625                 630                 635                 640 


Arg Asn Lys Val Leu Val Thr Ser Gln Glu Asn Arg Gln Lys Gly Asn 
                645                 650                 655     


Arg Thr Pro Tyr Glu Tyr Met Gly Asn Asp Glu Gln Arg Trp Asn Glu 
            660                 665                 670         


Phe Glu Thr Arg Val Lys Thr Thr Ile Arg Asp Tyr Lys Lys Gln Gln 
        675                 680                 685             


Lys Leu Leu Lys Lys His Phe Ser Glu Glu Glu Arg Ser Glu Phe Lys 
    690                 695                 700                 


Glu Arg Asn Leu Thr Asp Thr Lys Tyr Ile Thr Thr Val Ile Tyr Asn 
705                 710                 715                 720 


Met Ile Arg Gln Asn Leu Glu Met Ala Pro Leu Asn Arg Pro Glu Lys 
                725                 730                 735     


Lys Lys Gln Val Arg Ala Val Asn Gly Ala Ile Thr Ala Tyr Leu Arg 
            740                 745                 750         


Lys Arg Trp Gly Leu Pro Gln Lys Asn Arg Glu Thr Asp Thr His His 
        755                 760                 765             


Ala Met Asp Ala Val Val Ile Ala Cys Cys Thr Asp Gly Met Ile Gln 
    770                 775                 780                 


Lys Ile Ser Arg Tyr Thr Lys Val Arg Glu Arg Cys Tyr Ser Lys Gly 
785                 790                 795                 800 


Thr Glu Phe Val Asp Ala Glu Thr Gly Glu Ile Phe Arg Pro Glu Asp 
                805                 810                 815     


Tyr Ser Arg Ala Glu Trp Asp Glu Ile Phe Gly Val His Ile Pro Lys 
            820                 825                 830         


Pro Trp Glu Thr Phe Arg Ala Glu Leu Asp Val Arg Met Gly Asp Asp 
        835                 840                 845             


Pro Lys Gly Phe Leu Asp Thr His Ser Asp Val Ala Leu Glu Leu Asp 
    850                 855                 860                 


Tyr Pro Glu Tyr Ile Tyr Glu Asn Leu Arg Pro Ile Phe Val Ser Arg 
865                 870                 875                 880 


Met Pro Asn His Lys Val Thr Gly Ala Ala His Ala Asp Thr Ile Arg 
                885                 890                 895     


Ser Pro Arg His Phe Lys Asp Glu Gly Ile Val Leu Thr Lys Thr Ala 
            900                 905                 910         


Leu Thr Asp Leu Lys Leu Asp Lys Asp Gly Glu Ile Asp Gly Tyr Tyr 
        915                 920                 925             


Asn Pro Gln Ser Asp Leu Leu Leu Tyr Glu Ala Leu Lys Lys Gln Leu 
    930                 935                 940                 


Leu Leu Tyr Gly Asn Asp Ala Lys Lys Ala Phe Ala Gln Asp Phe His 
945                 950                 955                 960 


Lys Pro Lys Ala Asp Gly Thr Glu Gly Pro Val Val Arg Lys Val Lys 
                965                 970                 975     


Ile Gln Lys Lys Gln Thr Met Gly Val Phe Val Asp Ser Gly Asn Gly 
            980                 985                 990         


Ile Ala Glu Asn Gly Gly Met Val  Arg Ile Asp Val Phe  Arg Val Asn 
        995                 1000                 1005             


Gly Lys  Tyr Tyr Phe Val Pro  Val Tyr Thr Ala Asp  Val Val Lys 
    1010                 1015                 1020             


Lys Val  Leu Pro Asn Arg Ala  Ser Thr Ala His Lys  Pro Tyr Gly 
    1025                 1030                 1035             


Glu Trp  Lys Val Met Glu Asp  Lys Asp Phe Leu Phe  Ser Leu Tyr 
    1040                 1045                 1050             


Ser Arg  Asp Leu Ile His Ile  Lys Ser Lys Lys Asp  Ile Pro Ile 
    1055                 1060                 1065             


Lys Met  Val Asn Gly Gly Met  Glu Gly Ile Lys Glu  Thr Tyr Ala 
    1070                 1075                 1080             


Tyr Tyr  Ile Gly Ala Asp Ile  Ser Ala Ala Asn Ile  Gln Gly Ile 
    1085                 1090                 1095             


Ala His  Asp Ser Arg Tyr Lys  Phe Arg Gly Leu Gly  Ile Gln Ser 
    1100                 1105                 1110             


Leu Asp  Val Leu Glu Lys Cys  Gln Ile Asp Val Leu  Gly His Val 
    1115                 1120                 1125             


Ser Val  Val Arg Ser Glu Lys  Arg Met Gly Phe Ser  
    1130                 1135                 1140 


<210> 414
<211> 1128
<212> PRT
<213> Roseburia intestinalis


<220>
<223> Roseburia intestinalis M50/1

<400> 414
Met Asp Glu Lys Met Asp Tyr Arg Ile Gly Leu Asp Ile Gly Ile Ala 
1               5                   10                  15      


Ser Val Gly Trp Ala Val Leu Gln Asn Asn Ser Asp Asp Glu Pro Val 
            20                  25                  30          


Arg Ile Val Asp Leu Gly Val Arg Ile Phe Asp Thr Ala Glu Ile Pro 
        35                  40                  45              


Lys Thr Gly Glu Ser Leu Ala Gly Pro Arg Arg Ala Ala Arg Thr Thr 
    50                  55                  60                  


Arg Arg Arg Leu Arg Arg Arg Lys His Arg Leu Asp Arg Ile Lys Trp 
65                  70                  75                  80  


Leu Phe Glu Asn Gln Gly Leu Ile Asn Ile Asp Asp Phe Leu Lys Arg 
                85                  90                  95      


Tyr Asn Met Ala Gly Leu Pro Asp Val Tyr Gln Leu Arg Tyr Glu Ala 
            100                 105                 110         


Leu Asp Arg Lys Leu Thr Asp Glu Glu Leu Ala Gln Val Leu Leu His 
        115                 120                 125             


Ile Ala Lys His Arg Gly Phe Arg Ser Thr Arg Lys Ala Glu Thr Ala 
    130                 135                 140                 


Ala Lys Glu Asn Gly Ala Val Leu Lys Ala Thr Asp Glu Asn Gln Lys 
145                 150                 155                 160 


Arg Met Gln Glu Lys Gly Tyr Arg Thr Val Gly Glu Met Ile Tyr Leu 
                165                 170                 175     


Asp Glu Ala Phe Arg Ile Gly Cys Ser Trp Ser Glu Lys Gly Tyr Ile 
            180                 185                 190         


Leu Thr Pro Arg Asn Lys Ala Glu Asn Tyr Gln His Thr Met Leu Arg 
        195                 200                 205             


Ala Met Leu Val Glu Glu Val Lys Glu Ile Phe Ser Ser Gln Arg Arg 
    210                 215                 220                 


Leu Gly Asn Lys Lys Ala Thr Glu Glu Leu Glu Glu Lys Tyr Leu Glu 
225                 230                 235                 240 


Ile Met Thr Ser Gln Arg Ser Phe Asp Leu Gly Pro Gly Met Gln Pro 
                245                 250                 255     


Asp Gly Lys Pro Ser Pro Tyr Ala Met Glu Gly Phe Ser Asp Arg Val 
            260                 265                 270         


Gly Lys Cys Thr Phe Leu Gly Asp Gln Gly Glu Leu Arg Gly Ala Lys 
        275                 280                 285             


Gly Thr Tyr Thr Ala Glu Tyr Phe Val Ala Leu Gln Lys Ile Asn His 
    290                 295                 300                 


Thr Lys Leu Val Asn Gln Asp Gly Glu Thr Arg Asn Phe Thr Glu Glu 
305                 310                 315                 320 


Glu Arg Arg Ala Leu Thr Leu Leu Leu Phe Thr Gln Lys Glu Val Lys 
                325                 330                 335     


Tyr Ala Ala Val Arg Lys Lys Leu Gly Leu Pro Glu Asp Ile Leu Phe 
            340                 345                 350         


Tyr Asn Leu Asn Tyr Lys Lys Ala Ala Thr Lys Glu Glu Gln Gln Lys 
        355                 360                 365             


Glu Asn Gln Asn Thr Glu Lys Ala Lys Phe Ile Gly Met Pro Tyr Tyr 
    370                 375                 380                 


His Asp Tyr Lys Lys Cys Leu Glu Glu Arg Val Lys Tyr Leu Thr Glu 
385                 390                 395                 400 


Asn Glu Val Arg Asp Leu Phe Asp Glu Ile Gly Met Ile Leu Thr Cys 
                405                 410                 415     


Tyr Lys Asn Asp Asp Ser Arg Thr Glu Arg Leu Ala Lys Leu Gly Leu 
            420                 425                 430         


Val Pro Ile Glu Met Glu Gly Leu Leu Ala Tyr Thr Pro Thr Lys Phe 
        435                 440                 445             


Gln His Leu Ser Met Lys Ala Met Arg Asn Ile Ile Pro Phe Leu Glu 
    450                 455                 460                 


Lys Gly Met Thr Tyr Asp Lys Ala Cys Glu Glu Ala Gly Tyr Asp Phe 
465                 470                 475                 480 


Lys Ala Asp Ser Lys Gly Thr Lys Gln Lys Leu Leu Thr Gly Glu Asn 
                485                 490                 495     


Val Asn Gln Thr Ile Asn Glu Ile Thr Asn Pro Val Val Lys Arg Ser 
            500                 505                 510         


Val Ser Gln Thr Val Lys Val Ile Asn Ala Ile Ile Arg Thr Tyr Gly 
        515                 520                 525             


Ser Pro Gln Ala Ile Asn Ile Glu Leu Ala Arg Glu Met Ser Lys Thr 
    530                 535                 540                 


Phe Glu Glu Arg Arg Lys Ile Lys Gly Asp Met Glu Lys Arg Gln Lys 
545                 550                 555                 560 


Asn Asn Glu Asp Val Lys Lys Gln Ile Gln Glu Leu Gly Lys Leu Ser 
                565                 570                 575     


Pro Thr Gly Gln Asp Ile Leu Lys Tyr Arg Leu Trp Gln Glu Gln Gln 
            580                 585                 590         


Gly Ile Cys Met Tyr Ser Gly Lys Thr Ile Pro Leu Glu Glu Leu Phe 
        595                 600                 605             


Lys Pro Gly Tyr Asp Ile Asp His Ile Leu Pro Tyr Ser Ile Thr Phe 
    610                 615                 620                 


Asp Asp Ser Phe Arg Asn Lys Val Leu Val Thr Ser Gln Glu Asn Arg 
625                 630                 635                 640 


Gln Lys Gly Asn Arg Thr Pro Tyr Glu Tyr Met Gly Asn Asp Glu Gln 
                645                 650                 655     


Arg Trp Asn Glu Phe Glu Thr Arg Val Lys Thr Thr Ile Arg Asp Tyr 
            660                 665                 670         


Lys Lys Gln Gln Lys Leu Leu Lys Lys His Phe Ser Glu Glu Glu Arg 
        675                 680                 685             


Ser Glu Phe Lys Glu Arg Asn Leu Thr Asp Thr Lys Tyr Ile Thr Thr 
    690                 695                 700                 


Val Ile Tyr Asn Met Ile Arg Gln Asn Leu Glu Met Ala Pro Leu Asn 
705                 710                 715                 720 


Arg Pro Glu Lys Lys Lys Gln Val Arg Ala Val Asn Gly Ala Ile Thr 
                725                 730                 735     


Ala Tyr Leu Arg Lys Arg Trp Gly Leu Pro Gln Lys Asn Arg Glu Thr 
            740                 745                 750         


Asp Thr His His Ala Met Asp Ala Val Val Ile Ala Cys Cys Thr Asp 
        755                 760                 765             


Gly Met Ile Gln Lys Ile Ser Arg Tyr Thr Lys Val Arg Glu Arg Cys 
    770                 775                 780                 


Tyr Ser Lys Gly Thr Glu Phe Val Asp Ala Glu Thr Gly Glu Ile Phe 
785                 790                 795                 800 


Arg Pro Glu Asp Tyr Ser Arg Ala Glu Trp Asp Glu Ile Phe Gly Val 
                805                 810                 815     


His Ile Pro Lys Pro Trp Glu Thr Phe Arg Ala Glu Leu Asp Val Arg 
            820                 825                 830         


Met Gly Asp Asp Pro Lys Gly Phe Leu Asp Thr His Ser Asp Val Ala 
        835                 840                 845             


Leu Glu Leu Asp Tyr Pro Glu Tyr Ile Tyr Glu Asn Leu Arg Pro Ile 
    850                 855                 860                 


Phe Val Ser Arg Met Pro Asn His Lys Val Thr Gly Ala Ala His Ala 
865                 870                 875                 880 


Asp Thr Ile Arg Ser Pro Arg His Phe Lys Asp Glu Gly Ile Val Leu 
                885                 890                 895     


Thr Lys Thr Ala Leu Thr Asp Leu Lys Leu Asp Lys Asp Gly Glu Ile 
            900                 905                 910         


Asp Gly Tyr Tyr Asn Pro Gln Ser Asp Leu Leu Leu Tyr Glu Ala Leu 
        915                 920                 925             


Lys Lys Gln Leu Leu Leu Tyr Gly Asn Asp Ala Lys Lys Ala Phe Ala 
    930                 935                 940                 


Gln Asp Phe His Lys Pro Lys Ala Asp Gly Thr Glu Gly Pro Val Val 
945                 950                 955                 960 


Arg Lys Val Lys Ile Gln Lys Lys Gln Thr Met Gly Val Phe Val Asp 
                965                 970                 975     


Ser Gly Asn Gly Ile Ala Glu Asn Gly Gly Met Val Arg Ile Asp Val 
            980                 985                 990         


Phe Arg Val Asn Gly Lys Tyr Tyr  Phe Val Pro Val Tyr  Thr Ala Asp 
        995                 1000                 1005             


Val Val  Lys Lys Val Leu Pro  Asn Arg Ala Ser Thr  Ala Asn Lys 
    1010                 1015                 1020             


Pro Tyr  Ser Glu Trp Arg Thr  Met Glu Asp Lys Asp  Phe Leu Phe 
    1025                 1030                 1035             


Ser Leu  Tyr Ser Arg Asp Leu  Val His Ile Lys Ser  Lys Lys Gly 
    1040                 1045                 1050             


Ile Pro  Ile Lys Asn Val Asp  Gly Ser Leu Gly Glu  Ser Lys Glu 
    1055                 1060                 1065             


Val Tyr  Ala Tyr Tyr Ile Gly  Ala Asp Ile Ser Gly  Ala Lys Ile 
    1070                 1075                 1080             


Glu Gly  Lys Ala His Asp Ser  Arg Tyr Thr Phe Arg  Gly Ile Gly 
    1085                 1090                 1095             


Val Gln  Lys Leu Glu Leu Ile  Glu Lys Cys Gln Val  Asp Ile Leu 
    1100                 1105                 1110             


Gly His  Ile Ser Thr Val Lys  Asn Glu Lys Arg Met  Gly Phe Ser 
    1115                 1120                 1125             


<210> 415
<211> 1152
<212> PRT
<213> Roseburia inulinivorans


<220>
<223> Roseburia inulinivorans DSM 16841

<400> 415
Met Asn Ala Glu His Gly Lys Glu Gly Leu Leu Ile Met Glu Glu Asn 
1               5                   10                  15      


Phe Gln Tyr Arg Ile Gly Leu Asp Ile Gly Ile Thr Ser Val Gly Trp 
            20                  25                  30          


Ala Val Leu Gln Asn Asn Ser Gln Asp Glu Pro Val Arg Ile Thr Asp 
        35                  40                  45              


Leu Gly Val Arg Ile Phe Asp Val Ala Glu Asn Pro Lys Asn Gly Asp 
    50                  55                  60                  


Ala Leu Ala Ala Pro Arg Arg Asp Ala Arg Thr Thr Arg Arg Arg Leu 
65                  70                  75                  80  


Arg Arg Arg Arg His Arg Leu Glu Arg Ile Lys Phe Leu Leu Gln Glu 
                85                  90                  95      


Asn Gly Leu Ile Glu Met Asp Ser Phe Met Glu Arg Tyr Tyr Lys Gly 
            100                 105                 110         


Asn Leu Pro Asp Val Tyr Gln Leu Arg Tyr Glu Gly Leu Asp Arg Lys 
        115                 120                 125             


Leu Lys Asp Glu Glu Leu Ala Gln Val Leu Ile His Ile Ala Lys His 
    130                 135                 140                 


Arg Gly Phe Arg Ser Thr Arg Lys Ala Glu Thr Lys Glu Lys Glu Gly 
145                 150                 155                 160 


Gly Ala Val Leu Lys Ala Thr Thr Glu Asn Gln Lys Ile Met Gln Glu 
                165                 170                 175     


Lys Gly Tyr Arg Thr Val Gly Glu Met Leu Tyr Leu Asp Glu Ala Phe 
            180                 185                 190         


His Thr Glu Cys Leu Trp Asn Glu Lys Gly Tyr Val Leu Thr Pro Arg 
        195                 200                 205             


Asn Arg Pro Asp Asp Tyr Lys His Thr Ile Leu Arg Ser Met Leu Val 
    210                 215                 220                 


Glu Glu Val His Ala Ile Phe Ala Ala Gln Arg Ala His Gly Asn Gln 
225                 230                 235                 240 


Lys Ala Thr Glu Gly Leu Glu Glu Ala Tyr Val Glu Ile Met Thr Ser 
                245                 250                 255     


Gln Arg Ser Phe Asp Met Gly Pro Gly Leu Gln Pro Asp Gly Lys Pro 
            260                 265                 270         


Ser Pro Tyr Ala Met Glu Gly Phe Gly Asp Arg Val Gly Lys Cys Thr 
        275                 280                 285             


Phe Glu Lys Asp Glu Tyr Arg Ala Pro Lys Ala Thr Tyr Thr Ala Glu 
    290                 295                 300                 


Leu Phe Val Ala Leu Gln Lys Ile Asn His Thr Lys Leu Ile Asp Glu 
305                 310                 315                 320 


Phe Gly Thr Gly Arg Phe Phe Ser Glu Glu Glu Arg Lys Thr Ile Ile 
                325                 330                 335     


Gly Leu Leu Leu Ser Ser Lys Glu Leu Lys Tyr Gly Thr Ile Arg Lys 
            340                 345                 350         


Lys Leu Asn Ile Asp Pro Ser Leu Lys Phe Asn Ser Leu Asn Tyr Ser 
        355                 360                 365             


Ala Lys Lys Glu Gly Glu Thr Glu Glu Glu Arg Val Leu Asp Thr Glu 
    370                 375                 380                 


Lys Ala Lys Phe Ala Ser Met Phe Trp Thr Tyr Glu Tyr Ser Lys Cys 
385                 390                 395                 400 


Leu Lys Asp Arg Thr Glu Glu Met Pro Val Gly Glu Lys Ala Asp Leu 
                405                 410                 415     


Phe Asp Arg Ile Gly Glu Ile Leu Thr Ala Tyr Lys Asn Asp Asp Ser 
            420                 425                 430         


Arg Ser Ser Arg Leu Lys Glu Leu Gly Leu Ser Gly Glu Glu Ile Asp 
        435                 440                 445             


Gly Leu Leu Asp Leu Ser Pro Ala Lys Tyr Gln Arg Val Ser Leu Lys 
    450                 455                 460                 


Ala Met Arg Lys Met Gln Pro Tyr Leu Glu Asp Gly Leu Ile Tyr Asp 
465                 470                 475                 480 


Lys Ala Cys Glu Ala Ala Gly Tyr Asp Phe Arg Ala Leu Asn Asp Gly 
                485                 490                 495     


Asn Lys Lys His Leu Leu Lys Gly Glu Glu Ile Asn Ala Ile Val Asn 
            500                 505                 510         


Asp Ile Thr Asn Pro Val Val Lys Arg Ser Val Ser Gln Thr Ile Lys 
        515                 520                 525             


Val Ile Asn Ala Ile Ile Gln Lys Tyr Gly Ser Pro Gln Ala Val Asn 
    530                 535                 540                 


Ile Glu Leu Ala Arg Glu Met Ser Lys Asn Phe Gln Asp Arg Thr Asn 
545                 550                 555                 560 


Leu Glu Lys Glu Met Lys Lys Arg Gln Gln Glu Asn Glu Arg Ala Lys 
                565                 570                 575     


Gln Gln Ile Ile Glu Leu Gly Lys Gln Asn Pro Thr Gly Gln Asp Ile 
            580                 585                 590         


Leu Lys Tyr Arg Leu Trp Asn Asp Gln Gly Gly Tyr Cys Leu Tyr Ser 
        595                 600                 605             


Gly Lys Lys Ile Pro Leu Glu Glu Leu Phe Asp Gly Gly Tyr Asp Ile 
    610                 615                 620                 


Asp His Ile Leu Pro Tyr Ser Ile Thr Phe Asp Asp Ser Tyr Arg Asn 
625                 630                 635                 640 


Lys Val Leu Val Thr Ala Gln Glu Asn Arg Gln Lys Gly Asn Arg Thr 
                645                 650                 655     


Pro Tyr Glu Tyr Phe Gly Ala Asp Glu Lys Arg Trp Glu Asp Tyr Glu 
            660                 665                 670         


Ala Ser Val Arg Leu Leu Val Arg Asp Tyr Lys Lys Gln Gln Lys Leu 
        675                 680                 685             


Leu Lys Lys Asn Phe Thr Glu Glu Glu Arg Lys Glu Phe Lys Glu Arg 
    690                 695                 700                 


Asn Leu Asn Asp Thr Lys Tyr Ile Thr Arg Val Val Tyr Asn Met Ile 
705                 710                 715                 720 


Arg Gln Asn Leu Glu Leu Glu Pro Phe Asn His Pro Glu Lys Lys Lys 
                725                 730                 735     


Gln Val Trp Ala Val Asn Gly Ala Val Thr Ser Tyr Leu Arg Lys Arg 
            740                 745                 750         


Trp Gly Leu Met Gln Lys Asp Arg Ser Thr Asp Arg His His Ala Met 
        755                 760                 765             


Asp Ala Val Val Ile Ala Cys Cys Thr Asp Gly Met Ile His Lys Ile 
    770                 775                 780                 


Ser Arg Tyr Met Gln Gly Arg Glu Leu Ala Tyr Ser Arg Asn Phe Lys 
785                 790                 795                 800 


Phe Pro Asp Glu Glu Thr Gly Glu Ile Leu Asn Arg Asp Asn Phe Thr 
                805                 810                 815     


Arg Glu Gln Trp Asp Glu Lys Phe Gly Val Lys Val Pro Leu Pro Trp 
            820                 825                 830         


Asn Ser Phe Arg Asp Glu Leu Asp Ile Arg Leu Leu Asn Glu Asp Pro 
        835                 840                 845             


Lys Asn Phe Leu Leu Thr His Ala Asp Val Gln Arg Glu Leu Asp Tyr 
    850                 855                 860                 


Pro Gly Trp Met Tyr Gly Glu Glu Glu Ser Pro Ile Glu Glu Gly Arg 
865                 870                 875                 880 


Tyr Ile Asn Tyr Ile Arg Pro Leu Phe Val Ser Arg Met Pro Asn His 
                885                 890                 895     


Lys Val Thr Gly Ser Ala His Asp Ala Thr Ile Arg Ser Ala Arg Asp 
            900                 905                 910         


Tyr Glu Thr Arg Gly Val Val Ile Thr Lys Val Pro Leu Thr Asp Leu 
        915                 920                 925             


Lys Leu Asn Lys Asp Asn Glu Ile Glu Gly Tyr Tyr Asp Lys Asp Ser 
    930                 935                 940                 


Asp Arg Leu Leu Tyr Gln Ala Leu Val Arg Gln Leu Leu Leu His Gly 
945                 950                 955                 960 


Asn Asp Gly Lys Lys Ala Phe Ala Glu Asp Phe His Lys Pro Lys Ala 
                965                 970                 975     


Asp Gly Thr Glu Gly Pro Val Val Arg Lys Val Lys Ile Glu Lys Lys 
            980                 985                 990         


Gln Thr Ser Gly Val Met Val Arg  Gly Gly Thr Gly Ile  Ala Ala Asn 
        995                 1000                 1005             


Gly Glu  Met Val Arg Ile Asp  Val Phe Arg Glu Asn  Gly Lys Tyr 
    1010                 1015                 1020             


Tyr Phe  Val Pro Val Tyr Thr  Ala Asp Val Val Arg  Lys Val Leu 
    1025                 1030                 1035             


Pro Asn  Arg Ala Ala Thr His  Thr Lys Pro Tyr Ser  Glu Trp Arg 
    1040                 1045                 1050             


Val Met  Asp Asp Ala Asn Phe  Val Phe Ser Leu Tyr  Ser Arg Asp 
    1055                 1060                 1065             


Leu Ile  His Val Lys Ser Lys  Lys Asp Ile Lys Thr  Asn Leu Val 
    1070                 1075                 1080             


Asn Gly  Gly Leu Leu Leu Gln  Lys Glu Ile Phe Ala  Tyr Tyr Thr 
    1085                 1090                 1095             


Gly Ala  Asp Ile Ala Thr Ala  Ser Ile Ala Gly Phe  Ala Asn Asp 
    1100                 1105                 1110             


Ser Asn  Phe Lys Phe Arg Gly  Leu Gly Ile Gln Ser  Leu Glu Ile 
    1115                 1120                 1125             


Phe Glu  Lys Cys Gln Val Asp  Ile Leu Gly Asn Ile  Ser Val Val 
    1130                 1135                 1140             


Arg His  Glu Asn Arg Gln Glu  Phe His 
    1145                 1150         


<210> 416
<211> 1156
<212> PRT
<213> Ruminococcus albus


<220>
<223> Ruminococcus albus 8

<400> 416
Met Gly Asn Tyr Tyr Leu Gly Leu Asp Val Gly Ile Gly Ser Ile Gly 
1               5                   10                  15      


Trp Ala Val Ile Asn Ile Glu Lys Lys Arg Ile Glu Asp Phe Asn Val 
            20                  25                  30          


Arg Ile Phe Lys Ser Gly Glu Ile Gln Glu Lys Asn Arg Asn Ser Arg 
        35                  40                  45              


Ala Ser Gln Gln Cys Arg Arg Ser Arg Gly Leu Arg Arg Leu Tyr Arg 
    50                  55                  60                  


Arg Lys Ser His Arg Lys Leu Arg Leu Lys Asn Tyr Leu Ser Ile Ile 
65                  70                  75                  80  


Gly Leu Thr Thr Ser Glu Lys Ile Asp Tyr Tyr Tyr Glu Thr Ala Asp 
                85                  90                  95      


Asn Asn Val Ile Gln Leu Arg Asn Lys Gly Leu Ser Glu Lys Leu Thr 
            100                 105                 110         


Pro Glu Glu Ile Ala Ala Cys Leu Ile His Ile Cys Asn Asn Arg Gly 
        115                 120                 125             


Tyr Lys Asp Phe Tyr Glu Val Asn Val Glu Asp Ile Glu Asp Pro Asp 
    130                 135                 140                 


Glu Arg Asn Glu Tyr Lys Glu Glu His Asp Ser Ile Val Leu Ile Ser 
145                 150                 155                 160 


Asn Leu Met Asn Glu Gly Gly Tyr Cys Thr Pro Ala Glu Met Ile Cys 
                165                 170                 175     


Asn Cys Arg Glu Phe Asp Glu Pro Asn Ser Val Tyr Arg Lys Phe His 
            180                 185                 190         


Asn Ser Ala Ala Ser Lys Asn His Tyr Leu Ile Thr Arg His Met Leu 
        195                 200                 205             


Val Lys Glu Val Asp Leu Ile Leu Glu Asn Gln Ser Lys Tyr Tyr Gly 
    210                 215                 220                 


Ile Leu Asp Asp Lys Thr Ile Ala Lys Ile Lys Asp Ile Ile Phe Ala 
225                 230                 235                 240 


Gln Arg Asp Phe Glu Ile Gly Pro Gly Lys Asn Glu Arg Phe Arg Arg 
                245                 250                 255     


Phe Thr Gly Tyr Leu Asp Ser Ile Gly Lys Cys Gln Phe Phe Lys Asp 
            260                 265                 270         


Gln Glu Arg Gly Ser Arg Phe Thr Val Ile Ala Asp Ile Tyr Ala Phe 
        275                 280                 285             


Val Asn Val Leu Ser Gln Tyr Thr Tyr Thr Asn Asn Arg Gly Glu Ser 
    290                 295                 300                 


Val Phe Asp Thr Ser Phe Ala Asn Asp Leu Ile Asn Ser Ala Leu Lys 
305                 310                 315                 320 


Asn Gly Ser Met Asp Lys Arg Glu Leu Lys Ala Ile Ala Lys Ser Tyr 
                325                 330                 335     


His Ile Asp Ile Ser Asp Lys Asn Ser Asp Thr Ser Leu Thr Lys Cys 
            340                 345                 350         


Phe Lys Tyr Ile Lys Val Val Lys Pro Leu Phe Glu Lys Tyr Gly Tyr 
        355                 360                 365             


Asp Trp Asp Lys Leu Ile Glu Asn Tyr Thr Asp Thr Asp Asn Asn Val 
    370                 375                 380                 


Leu Asn Arg Ile Gly Ile Val Leu Ser Gln Ala Gln Thr Pro Lys Arg 
385                 390                 395                 400 


Arg Arg Glu Lys Leu Lys Ala Leu Asn Ile Gly Leu Asp Asp Gly Leu 
                405                 410                 415     


Ile Asn Glu Leu Thr Lys Leu Lys Leu Ser Gly Thr Ala Asn Val Ser 
            420                 425                 430         


Tyr Lys Tyr Met Gln Gly Ser Ile Glu Ala Phe Cys Glu Gly Asp Leu 
        435                 440                 445             


Tyr Gly Lys Tyr Gln Ala Lys Phe Asn Lys Glu Ile Pro Asp Ile Asp 
    450                 455                 460                 


Glu Asn Ala Lys Pro Gln Lys Leu Pro Pro Phe Lys Asn Glu Asp Asp 
465                 470                 475                 480 


Cys Glu Phe Phe Lys Asn Pro Val Val Phe Arg Ser Ile Asn Glu Thr 
                485                 490                 495     


Arg Lys Leu Ile Asn Ala Ile Ile Asp Lys Tyr Gly Tyr Pro Ala Ala 
            500                 505                 510         


Val Asn Ile Glu Thr Ala Asp Glu Leu Asn Lys Thr Phe Glu Asp Arg 
        515                 520                 525             


Ala Ile Asp Thr Lys Arg Asn Asn Asp Asn Gln Lys Glu Asn Asp Arg 
    530                 535                 540                 


Ile Val Lys Glu Ile Ile Glu Cys Ile Lys Cys Asp Glu Val His Ala 
545                 550                 555                 560 


Arg His Leu Ile Glu Lys Tyr Lys Leu Trp Glu Ala Gln Glu Gly Lys 
                565                 570                 575     


Cys Leu Tyr Ser Gly Glu Thr Ile Thr Lys Glu Asp Met Leu Arg Asp 
            580                 585                 590         


Lys Asp Lys Leu Phe Glu Val Asp His Ile Val Pro Tyr Ser Leu Ile 
        595                 600                 605             


Leu Asp Asn Thr Ile Asn Asn Lys Ala Leu Val Tyr Ala Glu Glu Asn 
    610                 615                 620                 


Gln Lys Lys Gly Gln Arg Thr Pro Leu Met Tyr Met Asn Glu Ala Gln 
625                 630                 635                 640 


Ala Ala Asp Tyr Arg Val Arg Val Asn Thr Met Phe Lys Ser Lys Lys 
                645                 650                 655     


Cys Ser Lys Lys Lys Tyr Gln Tyr Leu Met Leu Pro Asp Leu Asn Asp 
            660                 665                 670         


Gln Glu Leu Leu Gly Gly Trp Arg Ser Arg Asn Leu Asn Asp Thr Arg 
        675                 680                 685             


Tyr Ile Cys Lys Tyr Leu Val Asn Tyr Leu Arg Lys Asn Leu Arg Phe 
    690                 695                 700                 


Asp Arg Ser Tyr Glu Ser Ser Asp Glu Asp Asp Leu Lys Ile Arg Asp 
705                 710                 715                 720 


His Tyr Arg Val Phe Pro Val Lys Ser Arg Phe Thr Ser Met Phe Arg 
                725                 730                 735     


Arg Trp Trp Leu Asn Glu Lys Thr Trp Gly Arg Tyr Asp Lys Ala Glu 
            740                 745                 750         


Leu Lys Lys Leu Thr Tyr Leu Asp His Ala Ala Asp Ala Ile Ile Ile 
        755                 760                 765             


Ala Asn Cys Arg Pro Glu Tyr Val Val Leu Ala Gly Glu Lys Leu Lys 
    770                 775                 780                 


Leu Asn Lys Met Tyr His Gln Ala Gly Lys Arg Ile Thr Pro Glu Tyr 
785                 790                 795                 800 


Glu Gln Ser Lys Lys Ala Cys Ile Asp Asn Leu Tyr Lys Leu Phe Arg 
                805                 810                 815     


Met Asp Arg Arg Thr Ala Glu Lys Leu Leu Ser Gly His Gly Arg Leu 
            820                 825                 830         


Thr Pro Ile Ile Pro Asn Leu Ser Glu Glu Val Asp Lys Arg Leu Trp 
        835                 840                 845             


Asp Lys Asn Ile Tyr Glu Gln Phe Trp Lys Asp Asp Lys Asp Lys Lys 
    850                 855                 860                 


Ser Cys Glu Glu Leu Tyr Arg Glu Asn Val Ala Ser Leu Tyr Lys Gly 
865                 870                 875                 880 


Asp Pro Lys Phe Ala Ser Ser Leu Ser Met Pro Val Ile Ser Leu Lys 
                885                 890                 895     


Pro Asp His Lys Tyr Arg Gly Thr Ile Thr Gly Glu Glu Ala Ile Arg 
            900                 905                 910         


Val Lys Glu Ile Asp Gly Lys Leu Ile Lys Leu Lys Arg Lys Ser Ile 
        915                 920                 925             


Ser Glu Ile Thr Ala Glu Ser Ile Asn Ser Ile Tyr Thr Asp Asp Lys 
    930                 935                 940                 


Ile Leu Ile Asp Ser Leu Lys Thr Ile Phe Glu Gln Ala Asp Tyr Lys 
945                 950                 955                 960 


Asp Val Gly Asp Tyr Leu Lys Lys Thr Asn Gln His Phe Phe Thr Thr 
                965                 970                 975     


Ser Ser Gly Lys Arg Val Asn Lys Val Thr Val Ile Glu Lys Val Pro 
            980                 985                 990         


Ser Arg Trp Leu Arg Lys Glu Ile  Asp Asp Asn Asn Phe  Ser Leu Leu 
        995                 1000                 1005             


Asn Asp  Ser Ser Tyr Tyr Cys  Ile Glu Leu Tyr Lys  Asp Ser Lys 
    1010                 1015                 1020             


Gly Asp  Asn Asn Leu Gln Gly  Ile Ala Met Ser Asp  Ile Val His 
    1025                 1030                 1035             


Asp Arg  Lys Thr Lys Lys Leu  Tyr Leu Lys Pro Asp  Phe Asn Tyr 
    1040                 1045                 1050             


Pro Asp  Asp Tyr Tyr Thr His  Val Met Tyr Ile Phe  Pro Gly Asp 
    1055                 1060                 1065             


Tyr Leu  Arg Ile Lys Ser Thr  Ser Lys Lys Ser Gly  Glu Gln Leu 
    1070                 1075                 1080             


Lys Phe  Glu Gly Tyr Phe Ile  Ser Val Lys Asn Val  Asn Glu Asn 
    1085                 1090                 1095             


Ser Phe  Arg Phe Ile Ser Asp  Asn Lys Pro Cys Ala  Lys Asp Lys 
    1100                 1105                 1110             


Arg Val  Ser Ile Thr Lys Lys  Asp Ile Val Ile Lys  Leu Ala Val 
    1115                 1120                 1125             


Asp Leu  Met Gly Lys Val Gln  Gly Glu Asn Asn Gly  Lys Gly Ile 
    1130                 1135                 1140             


Ser Cys  Gly Glu Pro Leu Ser  Leu Leu Lys Glu Lys  Asn 
    1145                 1150                 1155     


<210> 417
<211> 1341
<212> PRT
<213> Ruminococcus lactaris


<220>
<223> Ruminococcus lactaris ATCC 29176

<400> 417
Met Gly Lys Gly Tyr Tyr Val Gly Leu Asp Met Gly Thr Gly Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Thr Asp Glu Ser Tyr Gln Ile Leu Arg Arg His Gly 
            20                  25                  30          


Lys Ala Met Trp Gly Val Arg Leu Phe Glu Ser Ala Lys Thr Ala Glu 
        35                  40                  45              


Glu Arg Arg Met Phe Arg Thr Gly Arg Arg Arg Leu Asp Arg Arg Gly 
    50                  55                  60                  


Trp Arg Ile Glu Ile Leu Gln Glu Ile Phe Ala Glu Glu Ile Ser Arg 
65                  70                  75                  80  


Val Asp Pro Gly Phe Phe Leu Arg Met Lys Glu Ser Lys Tyr Tyr Pro 
                85                  90                  95      


Glu Asp Lys Arg Asp Ile Gln Gly Asn Cys Pro Glu Leu Pro Tyr Thr 
            100                 105                 110         


Leu Phe Val Asp Lys Thr Phe Thr Asp Lys Asp Phe His Lys Lys Tyr 
        115                 120                 125             


Pro Thr Ile Tyr His Leu Arg Lys Met Leu Met Glu Thr Glu Asp Thr 
    130                 135                 140                 


Pro Asp Met Arg Leu Val Tyr Leu Ala Leu His His Met Met Lys His 
145                 150                 155                 160 


Arg Gly His Phe Leu Leu Ser Gly Asp Ile Ser Gln Val Thr Glu Phe 
                165                 170                 175     


Lys Asn Thr Phe Asn Gln Phe Ile Glu Asn Ile Arg Asn Glu Glu Met 
            180                 185                 190         


Asp Phe Glu Ile Glu Leu Asp Glu Ser Ala Val Gln Met Ile Glu Glu 
        195                 200                 205             


Thr Leu Lys Asp Lys Asn Leu Thr Arg Ser Ala Lys Lys Ser Lys Leu 
    210                 215                 220                 


Val Lys Gly Leu Asn Ala Lys Asn Val Arg Asp Lys Ala Phe Leu Thr 
225                 230                 235                 240 


Leu Leu Ser Gly Gly Thr Val Lys Leu Ser Asp Leu Phe Gly Met Glu 
                245                 250                 255     


Glu Leu Asn Glu Gly Glu Arg Pro Lys Ile Ser Phe Ala Asp Asn Gly 
            260                 265                 270         


Tyr Glu Glu Tyr Ala Ala Val Val Glu Met Glu Leu Gly Glu Leu Tyr 
        275                 280                 285             


Tyr Ile Val Glu Ser Ala Lys Ala Val Tyr Asp Trp Ala Ile Leu Ser 
    290                 295                 300                 


Asp Ile Leu Gly Gly Ser Thr Ser Val Ser Asp Ala Lys Val Arg Ala 
305                 310                 315                 320 


Tyr Glu Lys His Lys Ala Asp Leu Lys Tyr Leu Lys Ala Val Val Lys 
                325                 330                 335     


Glu Tyr Phe Pro Lys Glu Val Tyr Asn Ala Val Phe Val Glu Ser Ser 
            340                 345                 350         


Asp Lys Leu Asn Asn Tyr Pro Ala Tyr Ile Gly Met Thr Lys Lys Asn 
        355                 360                 365             


Gly Lys Lys Val Ser Leu Glu Gly Lys Arg Cys Ser Arg Glu Glu Phe 
    370                 375                 380                 


Met Asp Phe Leu Lys Lys Asn Ile Val Val Lys Leu Pro Asp Glu Glu 
385                 390                 395                 400 


Ala Lys Met Tyr Leu Gln Ser Glu Leu Glu Lys Asp Ser Phe Leu Pro 
                405                 410                 415     


Lys Gln Val Asn Lys Asp Asn Gly Val Ile Pro Tyr Gln Val His Lys 
            420                 425                 430         


Tyr Glu Leu Lys Lys Ile Leu Asp Asn Leu Gly Asp Lys Ile Pro Phe 
        435                 440                 445             


Leu Lys Glu Asn Ala Glu Lys Ile Glu Lys Leu Phe Ser Phe Arg Ile 
    450                 455                 460                 


Pro Tyr Tyr Val Gly Pro Leu Arg Thr Gly Asn Gly Glu Asn Ser Lys 
465                 470                 475                 480 


Phe Ala Trp Ala Glu Arg Lys Ser Thr Glu Lys Ile Tyr Pro Trp Asn 
                485                 490                 495     


Phe Glu Asn Val Ile Asp Val Glu Gln Ser Ala Glu Asn Phe Ile Arg 
            500                 505                 510         


Arg Met Thr Asn Lys Cys Thr Tyr Leu Ile Gly Glu Asp Val Leu Pro 
        515                 520                 525             


Lys Asp Ser Leu Leu Tyr Ser Lys Phe Met Val Leu Asn Glu Leu Asn 
    530                 535                 540                 


Asn Leu Arg Leu Asp Gly Gln Lys Ile Ser Val Glu Leu Lys Gln Lys 
545                 550                 555                 560 


Ile Tyr Arg Asp Val Phe Cys Arg Ser Arg Lys Val Thr Gln Lys Lys 
                565                 570                 575     


Leu Lys Ser Tyr Leu Ile Arg Glu Gly Ile Ala Gly Lys Asn Val Glu 
            580                 585                 590         


Leu Thr Gly Ile Asp Gly Asp Phe Lys Gly Ser Leu Thr Ala Tyr His 
        595                 600                 605             


Asp Phe Lys Glu Lys Leu Ile Asp Val Glu Leu Thr Gln Lys Glu Lys 
    610                 615                 620                 


Glu Glu Ile Ile Leu Asn Ile Val Leu Phe Gly Asp Asp Lys Lys Leu 
625                 630                 635                 640 


Leu Lys Gln Arg Leu Lys Lys Lys Phe Pro Gln Leu Thr Glu Lys Gln 
                645                 650                 655     


Ile Asn Thr Val Thr Ala Leu Ser Tyr Lys Gly Trp Gly Arg Leu Ser 
            660                 665                 670         


Lys Lys Leu Leu Glu Glu Val Thr Val Pro Ala Pro Glu Thr Gly Glu 
        675                 680                 685             


Val Trp Asn Ile Ile Thr Ala Leu Trp Glu Thr Asn Asp Asn Phe Met 
    690                 695                 700                 


Gln Leu Leu Ser Lys Glu Tyr Gln Phe Ser Asp Arg Ile Glu Glu Phe 
705                 710                 715                 720 


Asn Glu Glu Lys Ala Asp Pro Glu Val Ser Tyr Gln Thr Ile Glu Asp 
                725                 730                 735     


Leu Tyr Val Ser Pro Ala Val Lys Arg Gln Ile Trp Gln Thr Leu Gln 
            740                 745                 750         


Ile Ile Gln Glu Ile Glu Lys Val Met Gly Glu Lys Pro Lys Arg Val 
        755                 760                 765             


Phe Val Glu Met Ala Arg Glu Lys Gln Glu Asn Lys Arg Thr Glu Ser 
    770                 775                 780                 


Arg Lys Lys Thr Leu Ser Asp Leu Tyr Thr Lys Cys Lys Lys Glu Glu 
785                 790                 795                 800 


Pro Glu Trp Ile Glu Ala Leu Cys Thr Ser Leu Glu Lys His Glu Glu 
                805                 810                 815     


His Gln Leu Arg Ser Asp Lys Leu Tyr Leu Tyr Tyr Thr Gln Lys Gly 
            820                 825                 830         


Arg Cys Met Tyr Ser Gly Glu Pro Ile Asp Leu Glu Asp Leu Trp Asp 
        835                 840                 845             


Asn Thr Lys Tyr Asp Ile Asp His Ile Tyr Pro Gln Ser Lys Thr Met 
    850                 855                 860                 


Asp Asp Ser Leu Lys Asn Arg Val Leu Val Lys Lys Glu Tyr Asn Ala 
865                 870                 875                 880 


Lys Lys Ser Asp Thr Tyr Pro Ile Ala Ala Asp Ile Gln Lys Lys Met 
                885                 890                 895     


Met Pro Phe Trp Lys Ser Leu Leu Thr Gly Gly Phe Ile Pro Lys Glu 
            900                 905                 910         


Lys Tyr Asp Arg Leu Val Arg Asn Asn Pro Leu Asp Ala Asn Glu Leu 
        915                 920                 925             


Ala Gly Phe Ile Glu Arg Gln Ile Val Glu Thr Arg Gln Ser Thr Lys 
    930                 935                 940                 


Ala Val Ala Glu Ile Leu Lys Lys Ile Leu Pro Asp Thr Glu Ile Val 
945                 950                 955                 960 


Tyr Val Lys Ala Lys Thr Val Ser Lys Phe Arg Gln Asp Phe Asp Phe 
                965                 970                 975     


Ile Lys Val Arg Asp Met Asn Asp Leu His His Ala Lys Asp Ala Tyr 
            980                 985                 990         


Leu Asn Ile Val Val Gly Asn Val  Tyr Phe Val Lys Phe  Thr Lys Asn 
        995                 1000                 1005             


Ala Ala  Trp Phe Val Lys Glu  Asn Pro Gly Arg Thr  Tyr Asn Leu 
    1010                 1015                 1020             


Glu Lys  Met Phe Ile Trp Asp  Val Ala Arg Asp Gly  Glu Ile Ala 
    1025                 1030                 1035             


Trp Lys  Ala Gly Lys Ser Gly  Ser Ile Val Gln Val  Arg Ala Met 
    1040                 1045                 1050             


Met Glu  Lys Asn His Ile Leu  Val Thr Arg Arg Ser  Tyr Glu Val 
    1055                 1060                 1065             


Lys Gly  Gly Leu Phe Asp Gln  Gln Ile Leu Lys Lys  Gly Lys Gly 
    1070                 1075                 1080             


Gln Val  Pro Val Lys Glu Ser  Asp Glu Arg Leu Arg  Asp Ile Gly 
    1085                 1090                 1095             


Lys Tyr  Gly Gly Tyr Asn Lys  Ala Ala Gly Val Tyr  Phe Met Leu 
    1100                 1105                 1110             


Val Ser  Ser Lys Asp Lys Lys  Gly Lys Glu Gln Arg  Thr Ile Glu 
    1115                 1120                 1125             


Phe Val  Pro Ile Tyr Leu Lys  Asp Arg Val Glu Lys  Asp Met Glu 
    1130                 1135                 1140             


Ser Ala  Arg Asn Tyr Leu Met  Glu Glu Arg Gly Leu  Arg Glu Pro 
    1145                 1150                 1155             


Lys Ile  Leu Ile Lys Lys Ile  Lys Ile Asp Thr Leu  Phe Lys Val 
    1160                 1165                 1170             


Asp Gly  Phe Tyr Met Trp Leu  Ser Gly Arg Thr Ser  Asn Gln Leu 
    1175                 1180                 1185             


Ile Phe  Lys Gly Ala Asn Gln  Leu Ile Leu Ser Lys  Glu Asp Met 
    1190                 1195                 1200             


Lys Thr  Leu Lys Lys Val Val  Lys Tyr Ile Gln Arg  Gln Lys Glu 
    1205                 1210                 1215             


Asp Lys  Asn Val Lys Ile Ser  Met Arg Asp Gly Ile  Thr Glu Glu 
    1220                 1225                 1230             


Glu Leu  Leu Lys Leu Tyr Glu  Thr Phe Leu Asp Lys  Ile Arg His 
    1235                 1240                 1245             


Ser Ile  Tyr Gly Ala Arg Leu  Ser Ser Gln Glu Lys  Thr Leu Val 
    1250                 1255                 1260             


Asn Gly  Lys Glu Lys Phe Ile  Asp Leu Ser Val Glu  Ala Lys Cys 
    1265                 1270                 1275             


Gln Val  Leu Tyr Glu Ile Leu  His Leu Phe Gln Cys  Gln Ser Gly 
    1280                 1285                 1290             


Ala Ala  Asn Leu Lys Met Ile  Gly Gly Pro Ala Ser  Ala Gly Ile 
    1295                 1300                 1305             


Leu Val  Met Asn Asn Asn Ile  Ser Lys Cys Lys Asn  Ile Ser Ile 
    1310                 1315                 1320             


Val Asn  Gln Ser Pro Thr Gly  Ile Tyr Glu Lys Glu  Ile Asp Leu 
    1325                 1330                 1335             


Leu Arg  Val 
    1340     


<210> 418
<211> 1471
<212> PRT
<213> Scardovia wiggsiae


<220>
<223> Scardovia wiggsiae F0424

<400> 418
Met Gly Tyr Lys Ala Pro Arg Asn Asp Lys Gly Glu Ile Asp Tyr Gly 
1               5                   10                  15      


Val Gly Leu Asp Leu Gly Asn Gly Ser Val Gly Trp Val Ala Met Asp 
            20                  25                  30          


Lys Asp Tyr His Leu Ile Arg Ala Arg Gly His Glu Leu Ile Gly Ala 
        35                  40                  45              


Arg Leu Phe Asp Pro Ala Asn Ser Ala Glu Asn Arg Arg Glu Ser Arg 
    50                  55                  60                  


Thr Thr Arg Arg Arg Leu Ser Arg Arg Arg Trp Arg Leu Arg Met Leu 
65                  70                  75                  80  


Asp Ser Leu Phe Ala Ser Glu Leu Ala Lys Ile Asp Pro Asn Phe Leu 
                85                  90                  95      


Ala Arg Arg Lys Tyr Ser Trp Val His Pro Lys Asp Glu Gln Asn His 
            100                 105                 110         


Glu Asn Trp Tyr Gly Ser Ile Ile Phe Gly Ser Lys Glu Gln Asp Lys 
        115                 120                 125             


Gln Phe Tyr Lys Asp Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu 
    130                 135                 140                 


Thr Glu Asp Thr Glu Arg His Asp Ile Arg Glu Ile Tyr Val Ala Ile 
145                 150                 155                 160 


His His Ile Val Lys Tyr Arg Gly His Phe Leu Arg Glu Gly Glu Ile 
                165                 170                 175     


Asn Ser Glu Asn Leu Phe Asp Pro Glu Gly Phe Val Glu Leu Ile Lys 
            180                 185                 190         


Asp Val Ile Lys Leu Asn Asn Ser Tyr Asp Glu Ser Thr Pro Ile Phe 
        195                 200                 205             


Glu Ala Ser Pro Ala Asp Val Ser Glu Ala Leu Leu Asn Glu His Thr 
    210                 215                 220                 


Ser Arg Ser Gly Arg Ile Glu Asp Thr Leu Asp Lys Leu Asp Phe Ser 
225                 230                 235                 240 


Val Ser Arg Val Asp Lys His Glu Leu Lys Gly Met Arg Asp Ala Ala 
                245                 250                 255     


Lys Ala Val Ile Gly Ala Ile Val Gly Asn Thr Ala Asp Phe Ser Lys 
            260                 265                 270         


Ile Phe Asn Leu Asp Asn Leu Asp Lys Asp Ser Lys Asp Asn Leu Lys 
        275                 280                 285             


Leu Lys Phe Ala Asp Ser Asn Phe Asp Glu Lys Tyr Gly Gly Val Val 
    290                 295                 300                 


Gly Ser Gly Leu Leu Asp Glu Thr Gln Ile Glu Leu Val Asp Arg Ile 
305                 310                 315                 320 


His Ala Val Tyr Asp Ala Val Ala Leu Lys Gly Ile Leu Gly Asp Ala 
                325                 330                 335     


His Thr Ile Ser Glu Ala Lys Val Glu Ser Tyr Glu Lys His Arg Lys 
            340                 345                 350         


Asn Trp Lys Leu Ile Lys Glu Glu Leu Arg Thr Lys Glu Asn Lys Asp 
        355                 360                 365             


Glu Val Asp Leu Trp Tyr Gly Asp Leu Ser Gly Arg Gln Tyr Lys Asn 
    370                 375                 380                 


Pro Pro Asp Pro Glu Lys Gly Pro Asp Glu Gly Ser Lys Lys Asp Ser 
385                 390                 395                 400 


Pro Ile Arg Asp Ser Asp Gln Lys Gln Asn Leu Ile Lys Lys Ala Asn 
                405                 410                 415     


Asp Tyr Phe Thr Glu Leu Ile Asp Asp Ser Gln Leu Ser Glu Glu Gln 
            420                 425                 430         


Lys Asn Cys Leu Lys Asn Asp Ile Asn Asn Gly Gln Leu Phe Pro Val 
        435                 440                 445             


Gln Arg Ser Ser Asp Asn Gly Val Ile Pro Tyr Gln Ile His Leu Asn 
    450                 455                 460                 


Glu Leu Arg Arg Ile Ile Glu Asn Gln Lys Gln Tyr Tyr Pro Phe Leu 
465                 470                 475                 480 


Ala Glu Thr Phe Ile Arg Lys Thr Ala Glu Gly Lys Ser Tyr Glu Glu 
                485                 490                 495     


Asn Lys Ile Val Ala Leu Leu Lys Phe Arg Val Pro Tyr Tyr Val Gly 
            500                 505                 510         


Pro Leu Val Ser Lys Glu Asp Met Glu Glu His Ser Ser Gly Asn Ser 
        515                 520                 525             


Ala Tyr His Trp Met Ala Arg Asn Pro Gly Arg Gly Glu Ala Ile Thr 
    530                 535                 540                 


Pro Trp Asn Phe Asp Glu Val Val Asp Lys Asp Glu Ser Gly Ala Arg 
545                 550                 555                 560 


Phe Ile Ser Arg Leu Thr Gly Thr Asp Thr Tyr Leu Leu Gly Glu Pro 
                565                 570                 575     


Thr Leu Pro Gln His Ser Leu Leu Tyr Glu Glu Tyr Met Val Leu Ser 
            580                 585                 590         


Glu Leu Asn Asn Val Arg Leu Asn Val Arg Gln Gly Asn His Trp Ser 
        595                 600                 605             


Asp Lys Asn Arg Gln Arg Leu Ser Tyr Lys Gln Lys Glu Phe Leu Ile 
    610                 615                 620                 


Glu Asn Leu Phe Lys Glu His Lys Thr Val Thr Arg Lys Arg Ala Glu 
625                 630                 635                 640 


Asp Cys Leu Ser Ser Met Gly Cys Gly Glu Val Gln Leu Phe Gly Leu 
                645                 650                 655     


Ser Asp Glu Lys Lys Phe Ala Ser Ser Leu Ser Ser Tyr Ile Thr Leu 
            660                 665                 670         


Lys Lys Ile Leu Gly Lys Ala Phe Val Asp Asp Ser Gly Asn Ser Ala 
        675                 680                 685             


Ile Leu Glu Arg Ile Ile Glu Val Gln Thr Val Phe Glu Asp Arg Glu 
    690                 695                 700                 


Pro Leu Thr His Gln Leu Ser Leu Ile Asp Ser Leu Thr Val Glu Gln 
705                 710                 715                 720 


Arg Lys Gln Leu Ala Lys Ile His Tyr Thr Gly Trp Gly Lys Leu Ser 
                725                 730                 735     


Arg Lys Leu Leu Thr Ser Lys Lys Gly Ser Tyr Lys Ile His Ser Gln 
            740                 745                 750         


Asn Glu Ile Met Arg Thr Gln His Ser Ile Ile Asp Ile Met Arg Gly 
        755                 760                 765             


Asp Ser Leu Asn Leu Ile Glu Ile Ile Arg Asp Lys Lys Ile Gly Ile 
    770                 775                 780                 


Gly Glu Trp Ile Asp Asn Glu Asn Leu Asp Arg Glu Thr Gly Glu Ser 
785                 790                 795                 800 


Asp Val Ser Arg Leu Glu Ser Val Phe Glu Gly Ile Val Met Ser Pro 
                805                 810                 815     


Arg Val Lys Arg Gly Val Val Gln Ala Val Arg Val Ile Asp Asp Leu 
            820                 825                 830         


Ala Lys Ala Ile Gly Asn Pro Pro Gln Arg Ile Phe Ile Glu Met Ala 
        835                 840                 845             


Asp Glu Val Gln Ala Ser Gln Arg Thr Val Ser Arg Leu Ser Arg Leu 
    850                 855                 860                 


Lys Ala Leu Tyr Gly Ser Pro Ser Leu Gln Lys Glu Phe Asn Asp Leu 
865                 870                 875                 880 


Lys Asp Leu Arg Lys Ser Leu Asn Glu Thr Lys Asp Ala Asp Leu Gln 
                885                 890                 895     


Glu Asp Arg Leu Tyr Leu Tyr Tyr Ile Gln Leu Gly Lys Asp Leu Tyr 
            900                 905                 910         


Thr Gly Lys Glu Ile Ser Ile Asp Ser Leu Ser Ser Ala Tyr Asp Ile 
        915                 920                 925             


Asp His Ile Val Pro Gln Ala Leu Thr Gln Asp Asp Ser Ile Asp Asn 
    930                 935                 940                 


Arg Val Leu Val Ser Arg Lys Glu Asn Ala Arg Lys Thr Asp Ser Tyr 
945                 950                 955                 960 


Leu Tyr Thr Pro Asp Leu Ile Lys Asn Met Arg Pro Leu Trp Gly Lys 
                965                 970                 975     


Leu Leu Ala Ala Gly Leu Met Ser Gln Lys Lys Tyr Asp Ala Leu Thr 
            980                 985                 990         


Arg Val Asp Asp Phe Lys Asp Arg  Glu Lys Gln Arg Phe  Val Gln Arg 
        995                 1000                 1005             


Ser Leu  Val Glu Thr Arg Gln  Ile Met Lys Asn Val  Ser Thr Ile 
    1010                 1015                 1020             


Leu Arg  Thr Tyr Tyr Gly Glu  Asp Thr Asn Val Val  Thr Leu Lys 
    1025                 1030                 1035             


Ser Ser  Ile Thr His Asp Met  Arg Lys Tyr Leu Gly  Phe Pro Tyr 
    1040                 1045                 1050             


Lys Asn  Arg Asp Ile Asn Asp  Tyr His His Ala Gln  Asp Ala Leu 
    1055                 1060                 1065             


Cys Ile  Ser Ala Ala Gly Gln  Phe Met Leu Asn Arg  His Phe Val 
    1070                 1075                 1080             


Ser Gly  Gly Glu Val Thr Asp  Gly Ala Ser Asn Ala  Tyr Asn Met 
    1085                 1090                 1095             


Tyr Leu  Ala Glu Tyr Leu Gln  Glu Phe Arg Asp Ala  Lys Ala Arg 
    1100                 1105                 1110             


Gly Glu  Arg Lys Arg Ser Thr  Ala Phe Gly Phe Val  Val Gly Ser 
    1115                 1120                 1125             


Met Ser  Ser Lys Asp Asp Glu  Lys Arg Thr Asp His  Arg Thr Gly 
    1130                 1135                 1140             


Glu Ile  Val Trp Ser Glu Thr  Asn Ala Glu Tyr Leu  Arg Lys Val 
    1145                 1150                 1155             


Met Asn  Tyr Lys Lys Met Leu  Ile Thr Gln Lys Val  Gly Asp Val 
    1160                 1165                 1170             


Lys Thr  Arg Ala Leu Tyr Asp  Glu Thr Arg Tyr Gly  His Lys Glu 
    1175                 1180                 1185             


Ser Ser  Ala Lys Ser Ile Lys  Phe Asp Asn Leu Arg  Arg Asp Thr 
    1190                 1195                 1200             


Ser Leu  Tyr Gly Gly Phe Ser  Gly Ala Ser Thr Ala  Tyr Met Met 
    1205                 1210                 1215             


Leu Val  Glu Tyr Lys Lys Lys  Asn Lys Leu Val Ser  Ile Thr Ala 
    1220                 1225                 1230             


Gln Glu  Ala Ser Leu Leu Ala  Val Ala Asp Gln Lys  Asn Asp Thr 
    1235                 1240                 1245             


Val Ser  Val Met Asp Gly Ile  Leu Ala Ser His Gly  Leu Ser Gly 
    1250                 1255                 1260             


Ala Lys  Ile Leu Leu Pro Lys  Ile Val Thr Gly Gln  Leu Leu Asp 
    1265                 1270                 1275             


Tyr Ser  Asp Ala Leu Val Thr  Leu Gln Ser Ala Ser  Glu Leu Asn 
    1280                 1285                 1290             


Thr Ala  Arg Gln Met Trp Leu  Pro Arg Asn Asp Tyr  Asn Asp Ile 
    1295                 1300                 1305             


Asp Ile  Ile Leu Lys Ser Lys  Asp Ile Glu Asp Ala  Ala His Lys 
    1310                 1315                 1320             


Leu Gly  Tyr Asp Ser Asp Thr  Val His Val Leu Arg  Arg Ile Gln 
    1325                 1330                 1335             


Lys Leu  Phe Glu Ala Val Phe  Arg Val Ala Glu Ser  Gln Phe Pro 
    1340                 1345                 1350             


Leu His  Gln Leu Ser Lys Asp  Gln Gln Glu Glu Ile  Leu Arg Asp 
    1355                 1360                 1365             


Pro Gln  Asn Tyr Gly Phe Gly  Ser Ala Val Lys Leu  Leu Gly Gly 
    1370                 1375                 1380             


Leu Leu  Lys Ala Leu His Ala  Asn Ala Glu Asn Thr  Asn Leu Ala 
    1385                 1390                 1395             


Gly Leu  Val Lys Val Leu His  Gly Asp Lys Glu Tyr  Ser Asp Asp 
    1400                 1405                 1410             


Gly Lys  Ala Lys Glu Phe Lys  Lys Phe Gly Phe Ser  Pro Arg Trp 
    1415                 1420                 1425             


Arg Arg  Ile Ser Asn Pro Thr  Gly Phe Thr Leu Ser  Asp Ser Asp 
    1430                 1435                 1440             


Thr Phe  Ile Tyr Gln Ser Pro  Ser Gly Ile Phe Glu  Gln Arg Val 
    1445                 1450                 1455             


Thr Val  Lys Glu Leu Lys Glu  Lys Ala Asp Lys Gln  Lys 
    1460                 1465                 1470     


<210> 419
<211> 1178
<212> PRT
<213> Scardovia inopinata


<220>
<223> Scardovia inopinata F0304

<400> 419
Met Gly Lys Arg His Asn Ser Asn Met Ala Lys Lys Lys Ile Ser Tyr 
1               5                   10                  15      


Arg Ile Gly Ile Asp Val Gly Leu Asn Ser Thr Gly Leu Ala Ala Ile 
            20                  25                  30          


Glu Val Asp Asp Asp Gly Ala Pro Ile Arg Ile Leu Asn Thr Met Ser 
        35                  40                  45              


Val Ile His Asp Gly Gly Val Asp Pro Asp Ala Ala Lys Val Arg Gly 
    50                  55                  60                  


Thr Arg Leu Ala Ile Ser Gly Ile Ala Arg Arg Thr Arg Arg Met Arg 
65                  70                  75                  80  


Arg Arg Arg Ala Lys Arg Leu Asp Arg Leu Glu Gln Ile Leu Glu Lys 
                85                  90                  95      


Tyr Gly Tyr Thr Asp Thr Glu Pro Val Leu Glu Glu Pro Tyr Gly Pro 
            100                 105                 110         


Trp Ile Cys Arg Ala Glu Leu Ala Asp Gly Phe Ile Asn Asp Asp Glu 
        115                 120                 125             


Gln Arg Arg Met Met Ile Gly Ile Ala Ile Arg His Ile Ala Arg His 
    130                 135                 140                 


Arg Gly Trp Arg Asn Pro Tyr Gln Asn Val Arg Ala Leu Leu Asn Ile 
145                 150                 155                 160 


Asp Asp Ser Asp Leu Ser Glu Glu Tyr Lys Asn Leu Lys Glu Lys Val 
                165                 170                 175     


Gln Asp Gln Ile Asn Asp Gly Lys Asp Leu Pro Asn Phe Thr Pro Ser 
            180                 185                 190         


Gln Leu Val Arg Asp Tyr Leu Asp Asn Phe Ser Gly Gln Pro Ala Ala 
        195                 200                 205             


Arg Ile Arg Thr Gly Lys Ala Gly Pro Arg Gly Asn Arg Arg Asp Ala 
    210                 215                 220                 


Val Gly Ile Leu Pro Gln Arg Met Arg Gln Ser Asp Tyr Ala Tyr Glu 
225                 230                 235                 240 


Leu Gln Arg Ile Phe Asp Met Gln Lys Ile Gly Arg Asp Glu Ala Gln 
                245                 250                 255     


Glu Leu Leu Met Ala Val Phe Glu Ala Lys Ser Pro Lys Gly Ser Ala 
            260                 265                 270         


Glu Lys Arg Ile Gly Lys Asp Pro Leu Thr Gly Lys Lys Arg Ala Leu 
        275                 280                 285             


Lys Ala Ser Leu Ala Phe Gln Lys Tyr Arg Ile Val Ala Thr Ile Thr 
    290                 295                 300                 


Asn Leu Arg Ile Lys Thr Gly Thr Gly Ser Glu Arg Met Leu Ser Pro 
305                 310                 315                 320 


Thr Glu Leu Asn Asp Ile Tyr Thr Tyr Leu Leu Arg Val Gln Asp Asp 
                325                 330                 335     


Asn His Leu Pro Thr Trp Glu Asp Ile Cys Glu Glu Val Leu His Ile 
            340                 345                 350         


Gly Arg Tyr Gln Leu Ala Gly Ile Gly Lys Thr Phe Glu Gly Gly Glu 
        355                 360                 365             


Arg Ile Ser Asn Met Pro Pro Val Ile Gln Thr Ser Leu Ala Ile His 
    370                 375                 380                 


Gly Leu Ser Glu Gly Thr Leu Ala Glu Lys Leu Thr Lys Trp Trp Asp 
385                 390                 395                 400 


Lys Ala Asp Asp Asp Ser Arg Glu Ser Met Ile Lys Leu Leu Ser Asn 
                405                 410                 415     


Thr Val Asp Ile Asp Arg Val Asn Glu Val Asp Glu Asn Phe Ala Ser 
            420                 425                 430         


Ala Leu Asp Phe Ile Asp Ser Leu Asp Asp Glu Glu Leu Thr Lys Leu 
        435                 440                 445             


Asp Lys Ile Ala Leu Pro Arg Gly Arg Ala Ala Tyr Ser Glu Glu Ala 
    450                 455                 460                 


Leu Asn Lys Leu Thr Ala Asp Met Leu Asn Thr Gly Asp Asp Leu Phe 
465                 470                 475                 480 


Ser Ala Arg Gln Arg Ile Tyr His Val Asn Asn Ser Trp Arg Pro Pro 
                485                 490                 495     


Gln Pro Pro Ile Gly Glu Pro Leu Gly Asn Pro Ala Val Asp Arg Val 
            500                 505                 510         


Leu Lys Ile Thr Asn Arg Tyr Leu Met Asn Cys Leu Asn Arg Trp Gly 
        515                 520                 525             


Gln Pro Arg Arg Val Thr Ile Glu His Thr Arg Ser Gly Phe Thr Ser 
    530                 535                 540                 


Val Lys Gln Ala Thr Glu His Gln Lys Ile Ser Asp Lys Arg Ala Glu 
545                 550                 555                 560 


Tyr Arg Arg Asp Ile Val Lys Gln Leu Glu Glu Ala Gly Val Glu Ser 
                565                 570                 575     


Val His Glu Tyr Asp Ile Arg Arg Trp Glu Ala Val Gln Arg Gln Asn 
            580                 585                 590         


Gly Gln Cys Leu Tyr Cys Gly Arg Asp Ile Thr Phe Lys Thr Cys Glu 
        595                 600                 605             


Met Asp His Ile Val Pro Arg Lys Gly Pro Gly Ser Thr Asn Thr Arg 
    610                 615                 620                 


Thr Asn Phe Ala Ala Val Cys Pro Glu Cys Asn Arg Met Lys Ser Asn 
625                 630                 635                 640 


Ile Pro Phe Ala Ser Trp Ala Glu Thr Lys Glu Ala Lys Asp Arg Gly 
                645                 650                 655     


Val Ser Leu Asp Lys Ala Ile Lys Gln Val Arg Phe Phe Asn Phe Thr 
            660                 665                 670         


Lys Asn Glu Tyr Ser Pro Gln Ala Gln Arg Asn Phe Lys Lys Ser Met 
        675                 680                 685             


Ile Glu Arg Leu Lys Gln Lys Thr Ser Asp Glu Pro Leu Asp Asn Arg 
    690                 695                 700                 


Ser Ile Glu Ser Val Ser Trp Met Ala Asp Glu Leu Tyr Lys Arg Ile 
705                 710                 715                 720 


Asp Trp Tyr Phe Asn His Glu Gln Tyr Glu Thr Ser Lys Lys Ala Ile 
                725                 730                 735     


Asn Asp Asp Lys Asp Asn Leu Ser Gly Thr Gln Val Val Val Tyr Pro 
            740                 745                 750         


Gly Ser Ile Thr Ala Glu Ala Arg Asn Ala Ala Gly Leu Gly Gly Asn 
        755                 760                 765             


Ile His Phe Ile Gly Gly Arg Tyr Lys Thr Arg Leu Asp Arg Arg His 
    770                 775                 780                 


His Ala Val Asp Ala Cys Val Ile Ala Met Met Glu Pro Gly Ile Ala 
785                 790                 795                 800 


Arg Ile Leu Thr Glu Arg Asn Gln Leu Arg Gln Ala Gln Arg Leu Thr 
                805                 810                 815     


Ala Arg Ile Glu Asp Asp Glu Val Asn Trp Lys Asp Tyr Pro Thr Glu 
            820                 825                 830         


Asn Thr Ala Gly Tyr Asn Lys Tyr Gln Ala Trp Ser Asp Arg Met His 
        835                 840                 845             


Ala Leu Leu Glu Tyr Met Asn Asn Ala Leu Asp Tyr Asp Lys Ile Pro 
    850                 855                 860                 


Val Val Arg Trp Glu Arg Leu Gln Leu Gly Asn Arg Ser Ala His Glu 
865                 870                 875                 880 


Asp Thr Ile His Pro Leu Lys Lys Leu Pro Leu Ser His Glu Ile Ser 
                885                 890                 895     


Ala Ile Asp Ile Asn His Ala Ser Thr Pro Ala Leu Tyr Glu Ala Leu 
            900                 905                 910         


Val Ser Leu Pro Asp Phe Ser Glu Gln Asp Gly Leu Pro Ala Asp Pro 
        915                 920                 925             


Ser Arg Gln Ile Asn Val Asn Gly Glu Arg Tyr Ser Gly Asp Asp Leu 
    930                 935                 940                 


Val Ser Phe Phe Asn Ser Asn Ala Ala Gln Ile Ala Ile Gln Gly Gly 
945                 950                 955                 960 


Ser Ala Glu Leu Gly Thr Ala Phe His His Ala Arg Ile Tyr Arg Cys 
                965                 970                 975     


Trp Thr Val Gly Lys Asn Gly Lys Lys Lys Ile Phe Phe Gly Met Ile 
            980                 985                 990         


Arg Val Tyr Gln His Asp Leu Leu  His Ala Lys Asn Glu  Asp Leu Phe 
        995                 1000                 1005             


Thr Tyr  Pro Leu Lys Arg Ser  Ser Val Ser Met Arg  Tyr Ala Lys 
    1010                 1015                 1020             


Lys Glu  Val Val His Ala Ile  Leu Ser Gly Asn Ala  Glu Tyr Val 
    1025                 1030                 1035             


Gly Tyr  Leu Cys Val Gly Asp  Glu Leu Val Leu Asp  Leu Lys Gly 
    1040                 1045                 1050             


Asp Lys  Ser Asn Asp Glu Gly  Gly Ser Arg Leu Ser  Gly Gln Val 
    1055                 1060                 1065             


Gly Glu  Phe Val Gln Lys Phe  Glu Glu Asp Ser Lys  Val Asn Ser 
    1070                 1075                 1080             


Gln Ile  Val Asn Arg Trp Thr  Val Asp Gly Phe Pro  Asp Glu Ala 
    1085                 1090                 1095             


Lys Leu  Arg Leu Arg Pro Ser  Met Phe Ala Gly Glu  Gly Leu Lys 
    1100                 1105                 1110             


Asn Met  Lys Ser Glu Leu Val  Glu Asn Ala Ala Ile  Lys Asn Ile 
    1115                 1120                 1125             


Leu Ser  Lys Thr Gly Trp Arg  Val Ser Val Asp Val  Ile Ser Lys 
    1130                 1135                 1140             


Lys Ser  Pro Val Val Leu Arg  Arg Asn Ala Phe Gly  Glu Pro Arg 
    1145                 1150                 1155             


Trp Lys  Thr Asn Ala Gly Leu  Pro Val Ser Tyr Arg  Trp Gln Asp 
    1160                 1165                 1170             


Thr Glu  Thr Lys Glu 
    1175             


<210> 420
<211> 1063
<212> PRT
<213> Simonsiella muelleri


<220>
<223> Simonsiella muelleri ATCC 29453

<400> 420
Met Glu Lys Phe His Tyr Val Leu Gly Leu Asp Leu Gly Ile Ala Ser 
1               5                   10                  15      


Val Gly Trp Ala Ala Ile Glu Ile Asp Lys Glu Thr Glu Thr Ser Ile 
            20                  25                  30          


Gly Leu Leu Asp Cys Gly Val Arg Thr Phe Glu Arg Ala Glu Val Pro 
        35                  40                  45              


Lys Thr Gly Asp Ser Leu Ala Lys Ala Arg Arg Glu Ala Arg Ser Thr 
    50                  55                  60                  


Arg Arg Leu Ile Arg Arg Arg Ser His Arg Leu Leu Arg Leu Lys Arg 
65                  70                  75                  80  


Leu Leu Lys Arg Glu Ile Phe Arg Gln Pro Glu Thr Phe Lys Asp Leu 
                85                  90                  95      


Pro Ile Asn Ala Trp Gln Leu Arg Val Lys Gly Leu Asp Ser Arg Leu 
            100                 105                 110         


Asn Glu Tyr Glu Trp Ala Ala Val Leu Leu His Leu Val Lys His Arg 
        115                 120                 125             


Gly Tyr Leu Ser Gln Arg Lys Ser Glu Met Ser Glu Thr Asp Ser Lys 
    130                 135                 140                 


Ser Glu Met Gly Arg Leu Leu Ala Gly Val Ala Glu Asn His Gln Leu 
145                 150                 155                 160 


Leu Gln Gln Glu Gln Tyr Arg Thr Pro Ala Glu Leu Ala Leu Lys Lys 
                165                 170                 175     


Phe Val Lys His Phe Arg Asn Lys Gly Gly Asp Tyr Ala His Thr Phe 
            180                 185                 190         


Asn Arg Leu Asp Leu Gln Ala Glu Leu His Leu Leu Phe Gln Lys Gln 
        195                 200                 205             


Arg Glu Leu Gly Asn Pro Phe Thr Ser Pro Glu Leu Glu Arg Gln Val 
    210                 215                 220                 


Asp Asp Leu Leu Met Thr Gln Arg Ser Ala Leu Gln Gly Asp Ala Ile 
225                 230                 235                 240 


Leu Lys Met Leu Gly His Cys Gly Phe Glu Pro Glu Gln Phe Lys Ala 
                245                 250                 255     


Ala Lys Asn Thr Phe Ser Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu 
            260                 265                 270         


Asn Asn Leu Arg Ile Gln Asp Gln Gly Lys Glu Arg Ala Leu Thr Ala 
        275                 280                 285             


Asp Glu Arg Thr Lys Leu Leu Asp Glu Pro Tyr Lys Lys Ser Lys Leu 
    290                 295                 300                 


Thr Tyr Ala Gln Val Arg Lys Leu Leu Ser Leu Pro Gln Thr Ala Ile 
305                 310                 315                 320 


Phe Lys Gly Leu Arg Tyr Asp Leu Glu His Asp Lys Lys Ala Glu Asn 
                325                 330                 335     


Ser Thr Leu Met Glu Met Lys Ser Tyr His Asn Ile Arg Gln Thr Leu 
            340                 345                 350         


Glu Lys Ser Gly Leu Lys Thr Glu Trp Gln Ser Ile Ala Thr Gln Pro 
        355                 360                 365             


Glu Ile Leu Asp Ala Ile Gly Thr Ala Phe Ser Ile Tyr Lys Thr Asp 
    370                 375                 380                 


Glu Asp Ile Ser His Glu Leu Lys Thr Cys Arg Leu Pro Glu Asn Val 
385                 390                 395                 400 


Leu Asn Glu Leu Leu Lys Asn Ile Asn Phe Asp Gly Phe Ile Gln Leu 
                405                 410                 415     


Ser Leu Thr Ala Leu Arg Lys Ile Leu Pro Leu Met Glu Gln Gly Tyr 
            420                 425                 430         


Arg Tyr Asp Glu Ala Cys Thr Gln Ile Tyr Gly Asn His His Ser Gly 
        435                 440                 445             


Ser Leu Gln Gln Glu Ser Lys Gln Phe Leu Pro His Ile Pro Ile Asp 
    450                 455                 460                 


Asp Val Arg Asn Pro Val Val Phe Arg Thr Leu Thr Gln Ala Arg Lys 
465                 470                 475                 480 


Val Val Asn Ala Ile Ile Arg Arg Tyr Gly Ser Pro Ala Arg Val His 
                485                 490                 495     


Ile Glu Met Ala Arg Glu Leu Gly Lys Ser Lys Ser Asp Arg Asp Arg 
            500                 505                 510         


Ile Glu Lys Gln Gln Gln Lys Asn Lys Lys Glu Arg Glu Asn Ala Val 
        515                 520                 525             


Ala Lys Phe Lys Glu Asp Phe Pro Asp Phe Val Gly Glu Pro Arg Gly 
    530                 535                 540                 


Lys Asp Ile Leu Lys Met Arg Leu Tyr Glu Gln Gln His Gly Lys Cys 
545                 550                 555                 560 


Leu Tyr Ser Gly His Asp Ile Asp Ile Asn Arg Leu Asn Glu Lys Gly 
                565                 570                 575     


Tyr Val Glu Ile Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp 
            580                 585                 590         


Ser Gln Asn Asn Lys Val Leu Val Leu Gly Ser Glu Asn Gln Asn Lys 
        595                 600                 605             


Arg Asn Gln Thr Pro Asp Glu Tyr Leu Asp Gly Ala Asn Asn Ser Gln 
    610                 615                 620                 


Arg Trp Leu Glu Phe Gln Ala Arg Val Gln Thr Cys His Phe Ser Tyr 
625                 630                 635                 640 


Gly Lys Lys Gln Arg Ile Gln Leu Ala Lys Leu Asp Asp Glu Thr Glu 
                645                 650                 655     


Lys Gly Phe Leu Glu Arg Asn Leu Asn Asp Thr Arg Tyr Ile Ala Arg 
            660                 665                 670         


Phe Met Cys Gln Phe Val Gln Glu Asn Leu Tyr Leu Thr Gly Lys Gly 
        675                 680                 685             


Lys Arg Leu Val Phe Ala Ser Asn Gly Gly Met Thr Ala Thr Leu Arg 
    690                 695                 700                 


Asn Leu Trp Gly Leu Arg Lys Val Arg Glu Asp Asn Asp Arg His His 
705                 710                 715                 720 


Ala Leu Asp Ala Ile Val Val Ala Cys Ser Thr Ala Ser Met Gln Gln 
                725                 730                 735     


Lys Ile Thr Lys Ala Phe Gln Arg His Glu Ser Ile Glu Tyr Val Asp 
            740                 745                 750         


Thr Glu Thr Gly Glu Val Lys Phe Arg Ile Pro Gln Pro Trp Asp Phe 
        755                 760                 765             


Phe Arg Gln Glu Val Met Ile Arg Val Phe Ser Asp Gln Pro Cys Glu 
    770                 775                 780                 


Asp Leu Val Glu Lys Leu Ser Ala Arg Pro Glu Ala Leu His Asp Asn 
785                 790                 795                 800 


Val Thr Pro Leu Phe Val Ser Arg Ala Pro Asn Arg Lys Met Ser Gly 
                805                 810                 815     


Gln Gly His Leu Glu Thr Ile Lys Ser Ala Lys Arg Leu Ser Glu Glu 
            820                 825                 830         


Asn Ser Met Val Lys Lys Pro Leu Thr Thr Leu Lys Leu Lys Asp Ile 
        835                 840                 845             


Pro Glu Ile Val Gly Tyr Pro Ser Arg Glu Pro Gln Leu Tyr Ala Ala 
    850                 855                 860                 


Leu Lys Thr Arg Leu Glu Thr His Asp Asp Asp Pro Ile Lys Ala Phe 
865                 870                 875                 880 


Ala Lys Pro Phe Tyr Lys Pro Asn Lys Asn Gly Glu Leu Gly Ala Leu 
                885                 890                 895     


Val Arg Ser Val Arg Val Lys Gly Val Gln Asn Thr Gly Val Met Val 
            900                 905                 910         


His Asp Gly Lys Gly Ile Ala Asp Asn Ala Thr Met Val Arg Val Asp 
        915                 920                 925             


Val Tyr Thr Lys Ala Gly Lys Asn Tyr Leu Val Pro Val Tyr Val Trp 
    930                 935                 940                 


Gln Val Ala Gln Gly Ile Leu Pro Asn Arg Ala Val Thr Ser Gly Lys 
945                 950                 955                 960 


Ser Glu Ala Asp Trp Asp Leu Ile Asp Glu Ser Phe Glu Phe Lys Phe 
                965                 970                 975     


Ser Leu Ser Arg Gly Asp Leu Val Glu Met Ile Ser Asn Lys Gly Arg 
            980                 985                 990         


Ile Phe Gly Tyr Tyr Asn Gly Leu  Asp Arg Ala Asn Gly  Ser Ile Gly 
        995                 1000                 1005             


Ile Arg  Glu His Asp Leu Glu  Lys Ser Lys Gly Lys  Asp Gly Val 
    1010                 1015                 1020             


His Arg  Val Gly Val Lys Thr  Ala Thr Ala Phe Asn  Lys Tyr His 
    1025                 1030                 1035             


Val Asp  Pro Leu Gly Lys Glu  Ile His Arg Cys Ser  Ser Glu Pro 
    1040                 1045                 1050             


Arg Pro  Thr Leu Lys Ile Lys  Ser Lys Lys 
    1055                 1060             


<210> 421
<211> 1327
<212> PRT
<213> Solobacterium moorei


<220>
<223> Solobacterium moorei F0204

<400> 421
Met Glu Gly Gln Met Lys Asn Asn Gly Asn Asn Leu Gln Gln Gly Asn 
1               5                   10                  15      


Tyr Tyr Leu Gly Leu Asp Val Gly Thr Ser Ser Val Gly Trp Ala Val 
            20                  25                  30          


Thr Asp Thr Asp Tyr Asn Val Leu Lys Phe Arg Gly Lys Ser Met Trp 
        35                  40                  45              


Gly Ala Arg Leu Phe Asp Glu Ala Ser Thr Ala Glu Glu Arg Arg Thr 
    50                  55                  60                  


His Arg Gly Asn Arg Arg Arg Leu Ala Arg Arg Lys Tyr Arg Leu Leu 
65                  70                  75                  80  


Leu Leu Glu Gln Leu Phe Glu Lys Glu Ile Arg Lys Ile Asp Asp Asn 
                85                  90                  95      


Phe Phe Val Arg Leu His Glu Ser Asn Leu Trp Ala Asp Asp Lys Ser 
            100                 105                 110         


Lys Pro Ser Lys Phe Leu Leu Phe Asn Asp Thr Asn Phe Thr Asp Lys 
        115                 120                 125             


Asp Tyr Leu Lys Lys Tyr Pro Thr Ile Tyr His Leu Arg Ser Asp Leu 
    130                 135                 140                 


Ile His Asn Ser Thr Glu His Asp Ile Arg Leu Val Phe Leu Ala Leu 
145                 150                 155                 160 


His His Leu Ile Lys Tyr Arg Gly His Phe Ile Tyr Asp Asn Ser Ala 
                165                 170                 175     


Asn Gly Asp Val Lys Thr Leu Asp Glu Ala Val Ser Asp Phe Glu Glu 
            180                 185                 190         


Tyr Leu Asn Glu Asn Asp Ile Glu Phe Asn Ile Glu Asn Lys Lys Glu 
        195                 200                 205             


Phe Ile Asn Val Leu Ser Asp Lys His Leu Thr Lys Lys Glu Lys Lys 
    210                 215                 220                 


Ile Ser Leu Lys Lys Leu Tyr Gly Asp Ile Thr Asp Ser Glu Asn Ile 
225                 230                 235                 240 


Asn Ile Ser Val Leu Ile Glu Met Leu Ser Gly Ser Ser Ile Ser Leu 
                245                 250                 255     


Ser Asn Leu Phe Lys Asp Ile Glu Phe Asp Gly Lys Gln Asn Leu Ser 
            260                 265                 270         


Leu Asp Ser Asp Ile Glu Glu Thr Leu Asn Asp Val Val Asp Ile Leu 
        275                 280                 285             


Gly Asp Asn Ile Asp Leu Leu Ile His Ala Lys Glu Val Tyr Asp Ile 
    290                 295                 300                 


Ala Val Leu Thr Ser Ser Leu Gly Lys His Lys Tyr Leu Cys Asp Ala 
305                 310                 315                 320 


Lys Val Glu Leu Phe Glu Lys Asn Lys Lys Asp Leu Met Ile Leu Lys 
                325                 330                 335     


Lys Tyr Ile Lys Lys Asn His Pro Glu Asp Tyr Lys Lys Ile Phe Ser 
            340                 345                 350         


Ser Pro Thr Glu Lys Lys Asn Tyr Ala Ala Tyr Ser Gln Thr Asn Ser 
        355                 360                 365             


Lys Asn Val Cys Ser Gln Glu Glu Phe Cys Leu Phe Ile Lys Pro Tyr 
    370                 375                 380                 


Ile Arg Asp Met Val Lys Ser Glu Asn Glu Asp Glu Val Arg Ile Ala 
385                 390                 395                 400 


Lys Glu Val Glu Asp Lys Ser Phe Leu Thr Lys Leu Lys Gly Thr Asn 
                405                 410                 415     


Asn Ser Val Val Pro Tyr Gln Ile His Glu Arg Glu Leu Asn Gln Ile 
            420                 425                 430         


Leu Lys Asn Ile Val Ala Tyr Leu Pro Phe Met Asn Asp Glu Gln Glu 
        435                 440                 445             


Asp Ile Ser Val Val Asp Lys Ile Lys Leu Ile Phe Lys Phe Lys Ile 
    450                 455                 460                 


Pro Tyr Tyr Val Gly Pro Leu Asn Thr Lys Ser Thr Arg Ser Trp Val 
465                 470                 475                 480 


Tyr Arg Ser Asp Glu Lys Ile Tyr Pro Trp Asn Phe Ser Asn Val Ile 
                485                 490                 495     


Asp Leu Asp Lys Thr Ala His Glu Phe Met Asn Arg Leu Ile Gly Arg 
            500                 505                 510         


Cys Thr Tyr Thr Asn Asp Pro Val Leu Pro Met Asp Ser Leu Leu Tyr 
        515                 520                 525             


Ser Lys Tyr Asn Val Leu Asn Glu Ile Asn Pro Ile Lys Val Asn Gly 
    530                 535                 540                 


Lys Ala Ile Pro Val Glu Val Lys Gln Ala Ile Tyr Thr Asp Leu Phe 
545                 550                 555                 560 


Glu Asn Ser Lys Lys Lys Val Thr Arg Lys Ser Ile Tyr Ile Tyr Leu 
                565                 570                 575     


Leu Lys Asn Gly Tyr Ile Glu Lys Glu Asp Ile Val Ser Gly Ile Asp 
            580                 585                 590         


Ile Glu Ile Lys Ser Lys Leu Lys Ser His His Asp Phe Thr Gln Ile 
        595                 600                 605             


Val Gln Glu Asn Lys Cys Thr Pro Glu Glu Ile Glu Arg Ile Ile Lys 
    610                 615                 620                 


Gly Ile Leu Val Tyr Ser Asp Asp Lys Ser Met Leu Arg Arg Trp Leu 
625                 630                 635                 640 


Lys Asn Asn Ile Lys Gly Leu Ser Glu Asn Asp Val Lys Tyr Leu Ala 
                645                 650                 655     


Lys Leu Asn Tyr Lys Glu Trp Gly Arg Leu Ser Lys Thr Leu Leu Thr 
            660                 665                 670         


Asp Ile Tyr Thr Ile Asn Pro Glu Asp Gly Glu Ala Cys Ser Ile Leu 
        675                 680                 685             


Asp Ile Met Trp Asn Thr Asn Ala Thr Leu Met Glu Ile Leu Ser Asn 
    690                 695                 700                 


Glu Lys Tyr Gln Phe Lys Gln Asn Ile Glu Asn Tyr Lys Ala Glu Asn 
705                 710                 715                 720 


Tyr Asp Glu Lys Gln Asn Leu His Glu Glu Leu Asp Asp Met Tyr Ile 
                725                 730                 735     


Ser Pro Ala Ala Arg Arg Ser Ile Trp Gln Ala Leu Arg Ile Val Asp 
            740                 745                 750         


Glu Ile Val Asp Ile Lys Lys Ser Ala Pro Lys Lys Ile Phe Ile Glu 
        755                 760                 765             


Met Ala Arg Glu Lys Lys Ser Ala Met Lys Lys Lys Arg Thr Glu Ser 
    770                 775                 780                 


Arg Lys Asp Thr Leu Leu Glu Leu Tyr Lys Ser Cys Lys Ser Gln Ala 
785                 790                 795                 800 


Asp Gly Phe Tyr Asp Glu Glu Leu Phe Glu Lys Leu Ser Asn Glu Ser 
                805                 810                 815     


Asn Ser Arg Leu Arg Arg Asp Gln Leu Tyr Leu Tyr Tyr Thr Gln Met 
            820                 825                 830         


Gly Arg Ser Met Tyr Thr Gly Lys Arg Ile Asp Phe Asp Lys Leu Ile 
        835                 840                 845             


Asn Asp Lys Asn Thr Tyr Asp Ile Asp His Ile Tyr Pro Arg Ser Lys 
    850                 855                 860                 


Ile Lys Asp Asp Ser Ile Thr Asn Arg Val Leu Val Glu Lys Asp Ile 
865                 870                 875                 880 


Asn Gly Glu Lys Thr Asp Ile Tyr Pro Ile Ser Glu Asp Ile Arg Gln 
                885                 890                 895     


Lys Met Gln Pro Phe Trp Lys Ile Leu Lys Glu Lys Gly Leu Ile Asn 
            900                 905                 910         


Glu Glu Lys Tyr Lys Arg Leu Thr Arg Asn Tyr Glu Leu Thr Asp Glu 
        915                 920                 925             


Glu Leu Ser Ser Phe Val Ala Arg Gln Leu Val Glu Thr Gln Gln Ser 
    930                 935                 940                 


Thr Lys Ala Leu Ala Thr Leu Leu Lys Lys Glu Tyr Pro Ser Ala Lys 
945                 950                 955                 960 


Ile Val Tyr Ser Lys Ala Gly Asn Val Ser Glu Phe Arg Asn Arg Lys 
                965                 970                 975     


Asp Lys Glu Leu Pro Lys Phe Arg Glu Ile Asn Asp Leu His His Ala 
            980                 985                 990         


Lys Asp Ala Tyr Leu Asn Ile Val  Val Gly Asn Val Tyr  Asp Thr Lys 
        995                 1000                 1005             


Phe Thr  Glu Lys Phe Phe Asn  Asn Ile Arg Asn Glu  Asn Tyr Ser 
    1010                 1015                 1020             


Leu Lys  Arg Val Phe Asp Phe  Ser Val Pro Gly Ala  Trp Asp Ala 
    1025                 1030                 1035             


Lys Gly  Ser Thr Phe Asn Thr  Ile Lys Lys Tyr Met  Ala Lys Asn 
    1040                 1045                 1050             


Asn Pro  Ile Ile Ala Phe Ala  Pro Tyr Glu Val Lys  Gly Glu Leu 
    1055                 1060                 1065             


Phe Asp  Gln Gln Ile Val Pro  Lys Gly Lys Gly Gln  Phe Pro Ile 
    1070                 1075                 1080             


Lys Gln  Gly Lys Asp Ile Glu  Lys Tyr Gly Gly Tyr  Asn Lys Leu 
    1085                 1090                 1095             


Ser Ser  Ala Phe Leu Phe Ala  Val Glu Tyr Lys Gly  Lys Lys Ala 
    1100                 1105                 1110             


Arg Glu  Arg Ser Leu Glu Thr  Val Tyr Ile Lys Asp  Val Glu Leu 
    1115                 1120                 1125             


Tyr Leu  Gln Asp Pro Ile Lys  Tyr Cys Glu Ser Val  Leu Gly Leu 
    1130                 1135                 1140             


Lys Glu  Pro Gln Ile Ile Lys  Pro Lys Ile Leu Met  Gly Ser Leu 
    1145                 1150                 1155             


Phe Ser  Ile Asn Asn Lys Lys  Leu Val Val Thr Gly  Arg Ser Gly 
    1160                 1165                 1170             


Lys Gln  Tyr Val Cys His His  Ile Tyr Gln Leu Ser  Ile Asn Asp 
    1175                 1180                 1185             


Glu Asp  Ser Gln Tyr Leu Lys  Asn Ile Ala Lys Tyr  Leu Gln Glu 
    1190                 1195                 1200             


Glu Pro  Asp Gly Asn Ile Glu  Arg Gln Asn Ile Leu  Asn Ile Thr 
    1205                 1210                 1215             


Ser Val  Asn Asn Ile Lys Leu  Phe Asp Val Leu Cys  Thr Lys Phe 
    1220                 1225                 1230             


Asn Ser  Asn Thr Tyr Glu Ile  Ile Leu Asn Ser Leu  Lys Asn Asp 
    1235                 1240                 1245             


Val Asn  Glu Gly Arg Glu Lys  Phe Ser Glu Leu Asp  Ile Leu Glu 
    1250                 1255                 1260             


Gln Cys  Asn Ile Leu Leu Gln  Leu Leu Lys Ala Phe  Lys Cys Asn 
    1265                 1270                 1275             


Arg Glu  Ser Ser Asn Leu Glu  Lys Leu Asn Asn Lys  Lys Gln Ala 
    1280                 1285                 1290             


Gly Val  Ile Val Ile Pro His  Leu Phe Thr Lys Cys  Ser Val Phe 
    1295                 1300                 1305             


Lys Val  Ile His Gln Ser Ile  Thr Gly Leu Phe Glu  Lys Glu Met 
    1310                 1315                 1320             


Asp Leu  Leu Lys 
    1325         


<210> 422
<211> 1179
<212> PRT
<213> Sphaerochaeta globosa

<400> 422
Met Ser Lys Lys Val Ser Arg Arg Tyr Glu Glu Gln Ala Gln Glu Ile 
1               5                   10                  15      


Cys Gln Arg Leu Gly Ser Arg Pro Tyr Ser Ile Gly Leu Asp Leu Gly 
            20                  25                  30          


Val Gly Ser Ile Gly Val Ala Val Ala Ala Tyr Asp Pro Ile Lys Lys 
        35                  40                  45              


Gln Pro Ser Asp Leu Val Phe Val Ser Ser Arg Ile Phe Ile Pro Ser 
    50                  55                  60                  


Thr Gly Ala Ala Glu Arg Arg Gln Lys Arg Gly Gln Arg Asn Ser Leu 
65                  70                  75                  80  


Arg His Arg Ala Asn Arg Leu Lys Phe Leu Trp Lys Leu Leu Ala Glu 
                85                  90                  95      


Arg Asn Leu Met Leu Ser Tyr Ser Glu Gln Asp Val Pro Asp Pro Ala 
            100                 105                 110         


Arg Leu Arg Phe Glu Asp Ala Val Val Arg Ala Asn Pro Tyr Glu Leu 
        115                 120                 125             


Arg Leu Lys Gly Leu Asn Glu Gln Leu Thr Leu Ser Glu Leu Gly Tyr 
    130                 135                 140                 


Ala Leu Tyr His Ile Ala Asn His Arg Gly Ser Ser Ser Val Arg Thr 
145                 150                 155                 160 


Phe Leu Asp Glu Glu Lys Ser Ser Asp Asp Lys Lys Leu Glu Glu Gln 
                165                 170                 175     


Gln Ala Met Thr Glu Gln Leu Ala Lys Glu Lys Gly Ile Ser Thr Phe 
            180                 185                 190         


Ile Glu Val Leu Thr Ala Phe Asn Thr Asn Gly Leu Ile Gly Tyr Arg 
        195                 200                 205             


Asn Ser Glu Ser Val Lys Ser Lys Gly Val Pro Val Pro Thr Arg Asp 
    210                 215                 220                 


Ile Ile Ser Asn Glu Ile Asp Val Leu Leu Gln Thr Gln Lys Gln Phe 
225                 230                 235                 240 


Tyr Gln Glu Ile Leu Ser Asp Glu Tyr Cys Asp Arg Ile Val Ser Ala 
                245                 250                 255     


Ile Leu Phe Glu Asn Glu Lys Ile Val Pro Glu Ala Gly Cys Cys Pro 
            260                 265                 270         


Tyr Phe Pro Asp Glu Lys Lys Leu Pro Arg Cys His Phe Leu Asn Glu 
        275                 280                 285             


Glu Arg Arg Leu Trp Glu Ala Ile Asn Asn Ala Arg Ile Lys Met Pro 
    290                 295                 300                 


Met Gln Glu Gly Ala Ala Lys Arg Tyr Gln Ser Ala Ser Phe Ser Asp 
305                 310                 315                 320 


Glu Gln Arg His Ile Leu Phe His Ile Ala Arg Ser Gly Thr Asp Ile 
                325                 330                 335     


Thr Pro Lys Leu Val Gln Lys Glu Phe Pro Ala Leu Lys Thr Ser Ile 
            340                 345                 350         


Ile Val Leu Gln Gly Lys Glu Lys Ala Ile Gln Lys Ile Ala Gly Phe 
        355                 360                 365             


Arg Phe Arg Arg Leu Glu Glu Lys Ser Phe Trp Lys Arg Leu Ser Glu 
    370                 375                 380                 


Glu Gln Lys Asp Asp Phe Phe Ser Ala Trp Thr Asn Thr Pro Asp Asp 
385                 390                 395                 400 


Lys Arg Leu Ser Lys Tyr Leu Met Lys His Leu Leu Leu Thr Glu Asn 
                405                 410                 415     


Glu Val Val Asp Ala Leu Lys Thr Val Ser Leu Ile Gly Asp Tyr Gly 
            420                 425                 430         


Pro Ile Gly Lys Thr Ala Thr Gln Leu Leu Met Lys His Leu Glu Asp 
        435                 440                 445             


Gly Leu Thr Tyr Thr Glu Ala Leu Glu Arg Gly Met Glu Thr Gly Glu 
    450                 455                 460                 


Phe Gln Glu Leu Ser Val Trp Glu Gln Gln Ser Leu Leu Pro Tyr Tyr 
465                 470                 475                 480 


Gly Gln Ile Leu Thr Gly Ser Thr Gln Ala Leu Met Gly Lys Tyr Trp 
                485                 490                 495     


His Ser Ala Phe Lys Glu Lys Arg Asp Ser Glu Gly Phe Phe Lys Pro 
            500                 505                 510         


Asn Thr Asn Ser Asp Glu Glu Lys Tyr Gly Arg Ile Ala Asn Pro Val 
        515                 520                 525             


Val His Gln Thr Leu Asn Glu Leu Arg Lys Leu Met Asn Glu Leu Ile 
    530                 535                 540                 


Thr Ile Leu Gly Ala Lys Pro Gln Glu Ile Thr Val Glu Leu Ala Arg 
545                 550                 555                 560 


Glu Leu Lys Val Gly Ala Glu Lys Arg Glu Asp Ile Ile Lys Gln Gln 
                565                 570                 575     


Thr Lys Gln Glu Lys Glu Ala Val Leu Ala Tyr Ser Lys Tyr Cys Glu 
            580                 585                 590         


Pro Asn Asn Leu Asp Lys Arg Tyr Ile Glu Arg Phe Arg Leu Leu Glu 
        595                 600                 605             


Asp Gln Ala Phe Val Cys Pro Tyr Cys Leu Glu His Ile Ser Val Ala 
    610                 615                 620                 


Asp Ile Ala Ala Gly Arg Ala Asp Val Asp His Ile Phe Pro Arg Asp 
625                 630                 635                 640 


Asp Thr Ala Asp Asn Ser Tyr Gly Asn Lys Val Val Ala His Arg Gln 
                645                 650                 655     


Cys Asn Asp Ile Lys Gly Lys Arg Thr Pro Tyr Ala Ala Phe Ser Asn 
            660                 665                 670         


Thr Ser Ala Trp Gly Pro Ile Met His Tyr Leu Asp Glu Thr Pro Gly 
        675                 680                 685             


Met Trp Arg Lys Arg Arg Lys Phe Glu Thr Asn Glu Glu Glu Tyr Ala 
    690                 695                 700                 


Lys Tyr Leu Gln Ser Lys Gly Phe Val Ser Arg Phe Glu Ser Asp Asn 
705                 710                 715                 720 


Ser Tyr Ile Ala Lys Ala Ala Lys Glu Tyr Leu Arg Cys Leu Phe Asn 
                725                 730                 735     


Pro Asn Asn Val Thr Ala Val Gly Ser Leu Lys Gly Met Glu Thr Ser 
            740                 745                 750         


Ile Leu Arg Lys Ala Trp Asn Leu Gln Gly Ile Asp Asp Leu Leu Gly 
        755                 760                 765             


Ser Arg His Trp Ser Lys Asp Ala Asp Thr Ser Pro Thr Met Arg Lys 
    770                 775                 780                 


Asn Arg Asp Asp Asn Arg His His Gly Leu Asp Ala Ile Val Ala Leu 
785                 790                 795                 800 


Tyr Cys Ser Arg Ser Leu Val Gln Met Ile Asn Thr Met Ser Glu Gln 
                805                 810                 815     


Gly Lys Arg Ala Val Glu Ile Glu Ala Met Ile Pro Ile Pro Gly Tyr 
            820                 825                 830         


Ala Ser Glu Pro Asn Leu Ser Phe Glu Ala Gln Arg Glu Leu Phe Arg 
        835                 840                 845             


Lys Lys Ile Leu Glu Phe Met Asp Leu His Ala Phe Val Ser Met Lys 
    850                 855                 860                 


Thr Asp Asn Asp Ala Asn Gly Ala Leu Leu Lys Asp Thr Val Tyr Ser 
865                 870                 875                 880 


Ile Leu Gly Ala Asp Thr Gln Gly Glu Asp Leu Val Phe Val Val Lys 
                885                 890                 895     


Lys Lys Ile Lys Asp Ile Gly Val Lys Ile Gly Asp Tyr Glu Glu Val 
            900                 905                 910         


Ala Ser Ala Ile Arg Gly Arg Ile Thr Asp Lys Gln Pro Lys Trp Tyr 
        915                 920                 925             


Pro Met Glu Met Lys Asp Lys Ile Glu Gln Leu Gln Ser Lys Asn Glu 
    930                 935                 940                 


Ala Ala Leu Gln Lys Tyr Lys Glu Ser Leu Val Gln Ala Ala Ala Val 
945                 950                 955                 960 


Leu Glu Glu Ser Asn Arg Lys Leu Ile Glu Ser Gly Lys Lys Pro Ile 
                965                 970                 975     


Gln Leu Ser Glu Lys Thr Ile Ser Lys Lys Ala Leu Glu Leu Val Gly 
            980                 985                 990         


Gly Tyr Tyr Tyr Leu Ile Ser Asn  Asn Lys Arg Thr Lys  Thr Phe Val 
        995                 1000                 1005             


Val Lys  Glu Pro Ser Asn Glu  Val Lys Gly Phe Ala  Phe Asp Thr 
    1010                 1015                 1020             


Gly Ser  Asn Leu Cys Leu Asp  Phe Tyr His Asp Ala  Gln Gly Lys 
    1025                 1030                 1035             


Leu Cys  Gly Glu Ile Ile Arg  Lys Ile Gln Ala Met  Asn Pro Ser 
    1040                 1045                 1050             


Tyr Lys  Pro Ala Tyr Met Lys  Gln Gly Tyr Ser Leu  Tyr Val Arg 
    1055                 1060                 1065             


Leu Tyr  Gln Gly Asp Val Cys  Glu Leu Arg Ala Ser  Asp Leu Thr 
    1070                 1075                 1080             


Glu Ala  Glu Ser Asn Leu Ala  Lys Thr Thr His Val  Arg Leu Pro 
    1085                 1090                 1095             


Asn Ala  Lys Pro Gly Arg Thr  Phe Val Ile Ile Ile  Thr Phe Thr 
    1100                 1105                 1110             


Glu Met  Gly Ser Gly Tyr Gln  Ile Tyr Phe Ser Asn  Leu Ala Lys 
    1115                 1120                 1125             


Ser Lys  Lys Gly Gln Asp Thr  Ser Phe Thr Leu Thr  Thr Ile Lys 
    1130                 1135                 1140             


Asn Tyr  Asp Val Arg Lys Val  Gln Leu Ser Ser Ala  Gly Leu Val 
    1145                 1150                 1155             


Arg Tyr  Val Ser Pro Leu Leu  Val Asp Lys Ile Glu  Lys Asp Glu 
    1160                 1165                 1170             


Val Ala  Leu Cys Gly Glu 
    1175                 


<210> 423
<211> 1426
<212> PRT
<213> Sphingobacterium spiritivorum


<220>
<223> Sphingobacterium spiritivorum ATCC 33861

<400> 423
Met Lys His Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Ile Lys Gln Asp Phe Glu Asn Lys Gln Gly Glu Ile Leu Gly 
            20                  25                  30          


Met Gly Ser Arg Ile Ile Pro Met Ser Gln Asp Ile Leu Gly Asp Phe 
        35                  40                  45              


Gly Lys Gly Asn Ser Val Ser Gln Thr Ala Glu Arg Thr Lys Tyr Arg 
    50                  55                  60                  


Ser Val Arg Arg Leu Arg Glu Arg Phe Leu Leu Arg Arg Glu Arg Leu 
65                  70                  75                  80  


His Arg Ile Leu Asn Val Leu Gly Phe Leu Pro Glu His Tyr Ala Ser 
                85                  90                  95      


Gln Ile Asp Phe Thr Lys Arg Phe Gly Lys Phe Lys Glu Glu Thr Glu 
            100                 105                 110         


Pro Lys Leu Val Tyr Ser Asn Glu Gly Phe Ile Phe Lys Lys Ser Phe 
        115                 120                 125             


Glu Glu Met Leu Ser Asp Phe Lys Thr His Gln Pro Gln Leu Leu Glu 
    130                 135                 140                 


Asp Asn Lys Lys Ile Pro Tyr Asp Trp Thr Ile Tyr Tyr Leu Arg Lys 
145                 150                 155                 160 


Lys Ala Leu Ser Arg Lys Ile Glu Lys Glu Glu Leu Ala Trp Ile Leu 
                165                 170                 175     


Leu Asn Phe Asn Gln Lys Arg Gly Tyr Tyr Gln Leu Arg Gly Glu Glu 
            180                 185                 190         


Glu Glu Glu Asn Pro Asn Lys Leu Ile Glu Phe Tyr Ser Leu Lys Ile 
        195                 200                 205             


Val Asp Val Leu Ala Asp Glu Pro Gln Lys Gly Lys Ser Asp Ile Trp 
    210                 215                 220                 


Tyr Ser Leu Ile Leu Glu Asn Gly Trp Ile Tyr Arg Arg Ser Ser Lys 
225                 230                 235                 240 


Thr Pro Leu Phe Asp Trp Lys Glu Lys Thr Arg Asp Phe Ile Val Thr 
                245                 250                 255     


Ile Asp Leu Asn Asp Asp Gly Ser Val Lys Thr Asp Lys Glu Gly Asn 
            260                 265                 270         


Glu Lys Arg Ser Phe Arg Ala Pro Gly Glu Asn Asp Trp Thr Leu Val 
        275                 280                 285             


Lys Lys Lys Thr Glu Gln Glu Ile Asp Ser Ser Arg Lys Thr Val Gly 
    290                 295                 300                 


Thr Tyr Ile Tyr Glu Thr Leu Leu Lys Asn Pro Lys Gln Lys Ile Lys 
305                 310                 315                 320 


Gly Lys Leu Val Arg Thr Ile Glu Arg Lys Phe Tyr Lys Thr Glu Leu 
                325                 330                 335     


Lys Gln Ile Leu Glu Lys Gln Lys Glu Phe His Pro Glu Leu Arg Gln 
            340                 345                 350         


Asp Asp Leu Tyr Ser Asp Cys Val Arg Glu Leu Tyr Lys Asn Asn Glu 
        355                 360                 365             


Ala His Gln Leu Thr Leu Ser Lys Lys Asp Phe Val His Leu Phe Met 
    370                 375                 380                 


Glu Asp Ile Ile Phe Tyr Gln Arg Pro Leu Gly Ser Gln Lys Ser Ser 
385                 390                 395                 400 


Ile Ser Asn Cys Thr Leu Glu Phe Arg Lys Tyr Lys Asp Glu Asn Gly 
                405                 410                 415     


Thr Glu His Thr Gln Tyr Leu Lys Ala Ile Pro Lys Ser Asn Pro Tyr 
            420                 425                 430         


Tyr Gln Glu Phe Arg Ile Trp Gln Trp Met Tyr Asn Leu Asn Ile Tyr 
        435                 440                 445             


Lys Lys Glu Asp Asp Thr Asn Val Thr Lys Asp Phe Leu Asn Thr Lys 
    450                 455                 460                 


Ala Asp Phe Glu Ser Leu Phe Glu Phe Leu Asn Asn Arg Lys Glu Val 
465                 470                 475                 480 


Asp Gln Lys Ala Leu Leu Lys His Phe Lys Leu Asn Asp Lys Thr His 
                485                 490                 495     


Arg Trp Asn Tyr Val Glu Asp Lys Lys Tyr Pro Cys Asn Glu Thr Lys 
            500                 505                 510         


Thr Met Ile Leu Ser Arg Leu Asp Lys Val Glu Asn Ile Ser Asp Asp 
        515                 520                 525             


Phe Leu Thr Arg Glu Met Glu Gln Lys Ile Trp His Ile Ile Tyr Ser 
    530                 535                 540                 


Val Asn Asp Lys Val Glu Tyr Glu Lys Ala Leu Lys Ser Phe Ala Gly 
545                 550                 555                 560 


Lys Asn Asn Leu Glu Asp Asn Ser Phe Phe Glu Ala Phe Lys Lys Phe 
                565                 570                 575     


Pro Pro Phe Lys Ser Glu Tyr Gly Ala Phe Ser Glu Lys Ala Ile Lys 
            580                 585                 590         


Lys Leu Leu Pro Leu Met Arg Met Gly Lys Phe Trp Asn Tyr Asn Asn 
        595                 600                 605             


Ile Ser Glu Gln Ser Lys Ser Arg Ile Gln Lys Ile Ile Thr Gly Glu 
    610                 615                 620                 


Tyr Asp Glu Asn Ile Lys Asp Lys Val Arg Glu Lys Ala Ile His Leu 
625                 630                 635                 640 


Thr Thr Glu Thr Asp Phe Gln Gly Leu Gln Leu Trp Leu Val Gln Tyr 
                645                 650                 655     


Ile Val Tyr Gly Arg His Ser Glu Ala Ala Met Leu Gly Lys Trp Asn 
            660                 665                 670         


Ser Ala Asp Asp Leu Glu Glu Phe Leu Lys Glu Phe Lys Gln His Ser 
        675                 680                 685             


Leu Arg Asn Pro Ile Val Glu Gln Val Ile Thr Glu Thr Leu Arg Val 
    690                 695                 700                 


Val Lys Asp Ile Trp Gln Lys Tyr Gly Asn Gly Ala Lys Asp Phe Phe 
705                 710                 715                 720 


Arg Glu Ile His Ile Glu Leu Gly Arg Glu Met Lys Leu Pro Ala Glu 
                725                 730                 735     


Glu Arg Glu Arg Leu Thr Arg Gln Ile Ser Glu Asn Glu Asn Thr Asn 
            740                 745                 750         


Phe Arg Ile Lys Ala Leu Leu Ala Glu Met Met Asp Asp Asn Ser Val 
        755                 760                 765             


Glu Asn Val Arg Pro Phe Ser Pro Met Gln Gln Glu Ile Leu Lys Ile 
    770                 775                 780                 


Tyr Glu Glu Gly Val Leu Asn Ser Asp Ile Glu Ile Glu Asp Asp Ile 
785                 790                 795                 800 


Leu Lys Ile Ser Lys Thr Ala Gln Pro Ser Ser Ser Asp Leu Lys Arg 
                805                 810                 815     


Tyr Lys Leu Trp Leu Glu Gln Lys Tyr Lys Ser Pro Tyr Thr Gly Gln 
            820                 825                 830         


Ile Ile Pro Leu Asn Lys Leu Phe Thr Pro Glu Tyr Glu Ile Glu His 
        835                 840                 845             


Ile Ile Pro Gln Ser Arg Tyr Phe Asp Asp Ser Phe Thr Asn Lys Ile 
    850                 855                 860                 


Ile Cys Glu Ser Ala Val Asn Lys Leu Lys Asp Asn Tyr Ile Gly Leu 
865                 870                 875                 880 


Glu Phe Ile Lys Lys Leu Gly Gly Ser Ile Val Glu Cys Gly Asn Gly 
                885                 890                 895     


Lys Ser Val Ala Ile Leu Lys His Asp Ala Tyr Glu Asp Phe Ile Lys 
            900                 905                 910         


Lys His Tyr Ala Asn Asn Arg Ser Lys Arg Asn Lys Leu Leu Leu Glu 
        915                 920                 925             


Asp Ile Pro Glu Lys Met Ile Glu Arg Gln Met Asn Asp Thr Arg Tyr 
    930                 935                 940                 


Ile Ser Lys Tyr Ile Ser Gly Val Leu Ser Asn Ile Val Arg Val Glu 
945                 950                 955                 960 


Asp Gly Thr Asp Glu Gly Val Asn Ser Lys Asn Ile Val Pro Gly Asn 
                965                 970                 975     


Gly Lys Ile Thr Thr Gln Leu Lys Gln Asp Trp Gly Leu Asn Asp Val 
            980                 985                 990         


Trp Asn Asp Leu Ile Leu Pro Arg  Phe Glu Arg Met Asn  His Leu Thr 
        995                 1000                 1005             


Asn Ser  Thr Asp Phe Thr Ala  Trp Asn Glu Asn His  Gln Lys Phe 
    1010                 1015                 1020             


Leu Pro  Thr Val Pro Val Glu  Phe Ser Lys Gly Phe  Ser Lys Lys 
    1025                 1030                 1035             


Arg Ile  Asp His Arg His His  Ala Leu Asp Ala Leu  Val Ile Ala 
    1040                 1045                 1050             


Cys Ala  Thr Lys Asp His Val  Asn Leu Leu Asn Asn  Gln Ser Ala 
    1055                 1060                 1065             


Lys Ser  Asp Thr Lys Arg Tyr  Asp Leu Lys Lys Lys  Leu Met Lys 
    1070                 1075                 1080             


Phe Glu  Lys Val Ala Tyr Asn  His Pro Gln Thr Gly  Glu Arg Ile 
    1085                 1090                 1095             


Glu Arg  Glu Ala Pro Lys Gln  Phe Leu Lys Pro Trp  Glu Thr Phe 
    1100                 1105                 1110             


Thr Ile  Asp Ala Lys Asn His  Leu Glu Thr Ile Ile  Val Ser Phe 
    1115                 1120                 1125             


Lys Gln  Asn Leu Arg Val Ile  Asn Lys Ala Thr Asn  Tyr Tyr Glu 
    1130                 1135                 1140             


Lys Tyr  Val Glu Lys Glu Gly  Thr Lys Val Lys Glu  Arg Val Glu 
    1145                 1150                 1155             


Gln Lys  Gly Thr Asn Trp Ala  Ile Arg Lys Pro Met  His Lys Glu 
    1160                 1165                 1170             


Thr Val  Ser Gly Lys Ile Asp  Leu Pro Arg Ile Lys  Val Pro Lys 
    1175                 1180                 1185             


Gly Lys  Ile Leu Thr Ala Thr  Arg Lys Ser Leu Asp  Thr Ser Phe 
    1190                 1195                 1200             


Asn Leu  Lys Thr Ile Gly Ser  Ile Thr Asp Thr Gly  Ile Gln Lys 
    1205                 1210                 1215             


Ile Leu  Lys Asn Tyr Leu Gln  Tyr Lys Asp Asn Asn  Pro Glu Leu 
    1220                 1225                 1230             


Ala Phe  Ser Pro Glu Gly Ile  Glu Asp Met Asn Lys  Asn Ile Glu 
    1235                 1240                 1245             


Lys Phe  Asn Asn Gly Lys Ala  His Gln Ser Ile Ser  Lys Val Arg 
    1250                 1255                 1260             


Val Phe  Glu Leu Gly Ser Lys  Phe Pro Leu Gly Gln  Ser Gly Asn 
    1265                 1270                 1275             


Lys Lys  Glu Lys Tyr Val Glu  Ala Ala Lys Gly Thr  Asn Leu Phe 
    1280                 1285                 1290             


Phe Ala  Ile Tyr Gln Asp Lys  Asn Gly Lys Arg Ser  Tyr Glu Thr 
    1295                 1300                 1305             


Ile Pro  Leu Asn Glu Val Ile  Glu Arg Gln Lys Gln  Gly Leu Ser 
    1310                 1315                 1320             


Val Val  Asp Leu Lys Gly Val  Asp Asp Phe Tyr Leu  Ser Pro Asn 
    1325                 1330                 1335             


Asp Leu  Val Tyr Val Pro Ser  Glu Asp Glu Leu Glu  Asn Ile Ser 
    1340                 1345                 1350             


Met Ile  Asp Phe Asn Lys Met  Ser Ser Glu Arg Ile  Tyr Lys Val 
    1355                 1360                 1365             


Val Ser  Phe Thr Gly Asn Gln  Ile Phe Phe Val Arg  Gln Asp Ile 
    1370                 1375                 1380             


Ala Thr  Ser Val Val Asn Lys  Ala Glu Phe Ser Thr  Leu Asn Lys 
    1385                 1390                 1395             


Met Glu  Arg Ala Ile Asp Gly  Thr Met Ile Lys Glu  Thr Cys Val 
    1400                 1405                 1410             


Lys Leu  Gln Ile Asp Arg Leu  Gly Asn Ile Ser Lys  Ile 
    1415                 1420                 1425     


<210> 424
<211> 1110
<212> PRT
<213> Sphingobium sp.


<220>
<223> Sphingobium sp. AP49

<400> 424
Met Ala Glu Gly Lys Lys Arg Ile Trp Arg Leu Gly Ala Asp Leu Gly 
1               5                   10                  15      


Ala Asn Ser Leu Gly Trp Ala Ala Ile Glu Leu Ser Ala Pro Val Asn 
            20                  25                  30          


Gly Lys Pro Ile Ala Ile Leu Ala Ala Gly Ser Arg Ile Phe Ser Asp 
        35                  40                  45              


Gly Arg Asp Pro Lys Ser Gly Ala Ser Leu Ala Val Asp Arg Arg Asp 
    50                  55                  60                  


Ala Arg Ala Met Arg Arg Arg Arg Asp Arg Phe Lys Gln Arg Gln Lys 
65                  70                  75                  80  


Ala Leu Ile Lys Tyr Leu Ile Ala Asp Gly Leu Phe Pro Ala Asp Glu 
                85                  90                  95      


Ala Ala Arg Asn Ala Met Ala Ala Ile Asp Pro Tyr Ala Val Arg Ala 
            100                 105                 110         


Arg Ala Leu Asp Glu Ala Leu Ser Leu Pro Glu Leu Gly Arg Ala Leu 
        115                 120                 125             


Phe His Leu Asn Gln Arg Arg Gly Phe Lys Ser Asn Arg Lys Ala Asp 
    130                 135                 140                 


Arg Lys Ala Asp Asp Asp Ala Gly Lys Ile Ala Ile Gly Ile Asp Arg 
145                 150                 155                 160 


Thr Arg Asp Ala Ile Ala Glu Asp Glu Ala Asp Ala Gly Ala Glu Pro 
                165                 170                 175     


Gly Ser Trp Thr Phe Gly Lys Trp Leu His Glu Arg Arg Leu Lys Gly 
            180                 185                 190         


Gln Ser Val Arg Thr Arg Leu Arg Pro Glu Ser Gly Glu Asp Ala Lys 
        195                 200                 205             


Gly Asp Gly Tyr Asp Phe Tyr Pro Asp Arg Ala Leu Met Glu Glu Glu 
    210                 215                 220                 


Phe Asp Ala Ile Trp Ala Ala Gln Ala Pro His His Pro Asp Val Leu 
225                 230                 235                 240 


Thr Asn Asp Val His Asp Arg Leu His Glu Ile Ile Phe Tyr Gln Arg 
                245                 250                 255     


Pro Leu Lys Ala Pro Gln Val Gly Met Cys Ser Leu Ile Pro Gly Asp 
            260                 265                 270         


Arg Arg Leu Pro Lys Ala His Pro Leu Phe Gln Arg Arg Arg Leu Leu 
        275                 280                 285             


Glu Glu Leu Asn Ala Leu Met Ile Val Arg Pro Gly Glu Val Ala Gln 
    290                 295                 300                 


Arg Leu Thr Arg Glu Glu Arg Asp Ile Leu Leu Leu Lys Leu Lys Asp 
305                 310                 315                 320 


Lys Asn Lys Val Ser Phe Ala Thr Leu Arg Lys Ala Leu Lys Leu Asp 
                325                 330                 335     


Pro Asp Ala Arg Phe Asn Lys Glu Ser Glu Asp Arg Thr Asp Leu Lys 
            340                 345                 350         


Gly Asp Glu Val Ala Ala Val Met Gly Ser Lys Thr Arg Phe Gly Asn 
        355                 360                 365             


Leu Trp Val His Leu Ser Ile Glu Ala Gln Trp Asp Val Leu Ala Arg 
    370                 375                 380                 


Leu Asp Ala Val Glu Ser Asp Ala Glu Asp Ala Ala Phe Cys Ala Trp 
385                 390                 395                 400 


Leu Val Glu Thr Tyr Ala Leu Thr Pro Glu Gln Ala Arg Ala Val Ala 
                405                 410                 415     


Asn Ala Pro Leu Pro Pro Gly Tyr Gly Arg Phe Gly Glu Thr Ala Thr 
            420                 425                 430         


Arg Lys Leu Ile Glu Ala Leu Arg Asp Gly Lys Lys Asp Asp Arg Val 
        435                 440                 445             


Leu Val Tyr Ser Glu Ala Val Thr Glu Ala Gly Leu Gly His His Ser 
    450                 455                 460                 


Asp Arg Arg Thr Gly Glu Val Phe Glu Asp Ala Lys Gly Arg Pro Gln 
465                 470                 475                 480 


Leu Pro Tyr Tyr Gly Val Ala Leu Glu Arg His Ile Met Pro Gly Thr 
                485                 490                 495     


Gly Asp Pro Ser Asp Pro Glu Glu Met Arg Val Gly Arg Leu Thr Asn 
            500                 505                 510         


Pro Thr Val His Ile Gly Leu Asn Gln Leu Arg Arg Ile Leu Asn Val 
        515                 520                 525             


Leu Ile Arg Ala Tyr Gly Pro Pro Ala Glu Ile Ala Ile Glu Leu Ala 
    530                 535                 540                 


Arg Glu Leu Lys Leu Thr Asp Glu Asp Lys Lys Arg Ile Asn Arg Glu 
545                 550                 555                 560 


Asn Asn Asp Asn Arg Ile Ala Ala Glu Arg Arg Ser Glu Lys Leu Leu 
                565                 570                 575     


Ala Ile Gly Gln Ala Asp Ser Gly Ala Asn Arg Ala Leu Leu Lys Leu 
            580                 585                 590         


Trp Glu Glu Leu Asn Pro Ala Asn Val Leu Asp Arg Arg Cys Ile Tyr 
        595                 600                 605             


Ser Gly Arg Gln Ile Ser Ile Asp Met Leu Phe Ser Ala Ala Val Glu 
    610                 615                 620                 


Val Asp His Ile Leu Pro Phe Ala Ala Thr Leu Asp Asp Ser Asn Gly 
625                 630                 635                 640 


Asn Lys Ile Val Cys Leu Arg Glu Ala Asn Arg Glu Lys Arg Lys Arg 
                645                 650                 655     


Ser Pro His Asp Ala Trp Gly His Ser Ala Arg Trp Asp Glu Ile Ala 
            660                 665                 670         


Ala Arg Ala Ala Gln Leu Pro Arg Asn Lys Arg Trp Arg Phe Glu Pro 
        675                 680                 685             


Asp Ala Met Asp Lys Phe Arg Asp Glu Gly Gly Phe Gln Ala Arg His 
    690                 695                 700                 


Leu Val Asp Thr Gln Tyr Leu Ala Arg Leu Ser Arg Glu Tyr Leu Ala 
705                 710                 715                 720 


Thr Leu Tyr Pro Glu Lys Gly Glu Gly Ser Gly His Ile Trp Val Ser 
                725                 730                 735     


Pro Gly Arg Leu Thr Glu Met Val Arg Arg Lys Leu Gly Leu Asn Asp 
            740                 745                 750         


Leu Leu Pro Asp His Asn Phe Gly Gly Gly Ala Asp Gln Ala Lys Asn 
        755                 760                 765             


Arg Leu Asp His Arg His His Ala Ile Asp Ala Val Val Val Ala Ile 
    770                 775                 780                 


Val Asp Arg Gly Met Leu Asn Ala Ile Ala Arg Ala Ser Gly Gln Glu 
785                 790                 795                 800 


Gly Ala Glu Gly Arg Glu Arg Ile Ile Ile Pro Glu Pro Trp Asp Gly 
                805                 810                 815     


Phe Arg Asp Ala Leu Arg Glu Thr Val Asn Arg Ile Thr Val Ser His 
            820                 825                 830         


Arg Thr Asp His Gly Thr Ala Ser Lys Ala Gly Leu Pro Lys Gly Lys 
        835                 840                 845             


Asp Ala Thr Ala Gly Arg Leu His Asn Asp Thr Ala Tyr Gly Phe Thr 
    850                 855                 860                 


Gly Asp Thr Asp Ala Lys Gly Asn Ser Ile Val Val Arg Arg Val Pro 
865                 870                 875                 880 


Leu Ser Ser Phe Lys Lys Leu Ala Asp Leu Asp Arg Ile Arg Asp Ala 
                885                 890                 895     


Asp Leu Lys Ala Ala Leu Tyr Gln His Leu Asn Gly Leu Glu Gly Lys 
            900                 905                 910         


Ala Phe Glu Lys Ala Leu Ala Glu Phe His Lys Leu Glu Trp His Asn 
        915                 920                 925             


Phe Gly Gly Val Arg Arg Val Arg Val Thr Glu Pro Leu Thr Val Ile 
    930                 935                 940                 


Pro Ile Lys Asp Arg Asn Gly Arg Ile Tyr Lys Gly Tyr Lys Gly Asp 
945                 950                 955                 960 


Ser Asn Tyr Arg Tyr Asp Val Trp Glu Leu Pro Asp Gly Lys Trp Val 
                965                 970                 975     


Thr Asn Trp Lys Asn Glu Ala Gly Glu Ala Met Ser Ser Val Ile Ser 
            980                 985                 990         


Met Phe Asp Ala His Gln Ser Ser  Glu Pro Pro Arg Pro  His Pro Ala 
        995                 1000                 1005             


Ala Arg  Lys Ile Leu Ser Leu  His Gln Asn Asp Leu  Leu Ala Ile 
    1010                 1015                 1020             


Glu Arg  Glu Gly Glu Asp Arg  Lys Leu Met Arg Val  Val Lys Phe 
    1025                 1030                 1035             


Gly Gln  Ser Gly Gln Ile Thr  Leu Ala Glu His Gln  Gln Ala Gly 
    1040                 1045                 1050             


Asp Leu  Lys Lys Arg Asp Ala  Val Ser Asn Asp Asp  Asp Pro Phe 
    1055                 1060                 1065             


Lys Tyr  Phe Ala Pro Thr Ser  Gly Gly Leu Lys Lys  Val Lys Ala 
    1070                 1075                 1080             


Arg Gln  Val Arg Ile Asp Glu  Ile Gly Arg Val Leu  Asp Pro Gly 
    1085                 1090                 1095             


Phe Pro  Ala Arg Thr Ala Arg  Arg Lys Thr Arg Gly  
    1100                 1105                 1110 


<210> 425
<211> 1090
<212> PRT
<213> Sphingomonas sp.


<220>
<223> Sphingomonas sp. S17

<400> 425
Met Asp Trp Arg Leu Gly Leu Asp Leu Gly Ala Asn Ser Leu Gly Trp 
1               5                   10                  15      


Ala Ala Leu Arg Leu Asp Arg Ala Gly Asp Pro Ile Gly Ile Leu Ala 
            20                  25                  30          


Met Gly Ser Arg Ile Phe Ser Asp Gly Arg Asp Pro Lys Ser Gly Ala 
        35                  40                  45              


Ser Leu Ala Val Asp Arg Arg Ala Ala Arg Ala Met Arg Arg Arg Arg 
    50                  55                  60                  


Asp Arg Phe Lys Gln Arg Gln Ala Ala Leu Leu Lys Tyr Leu Ile Arg 
65                  70                  75                  80  


Asp Gly Leu Phe Pro Ala Asp Gln Ala Asp Arg Gln Arg Leu Ala Asp 
                85                  90                  95      


Glu Asp Pro Tyr Ala Leu Arg Ala Arg Ala Leu Asp Glu Glu Leu Ser 
            100                 105                 110         


Leu Phe Glu Ile Gly Arg Ala Leu Phe His Leu Asn Gln Arg Arg Gly 
        115                 120                 125             


Phe Gln Ser Asn Arg Lys Ala Asp Arg Gly Gln Asp Asp Glu Ala Gly 
    130                 135                 140                 


Lys Ile Ala Val Gly Val Asp Arg Leu Asn Gln Gln Met Glu Glu Gln 
145                 150                 155                 160 


Gly Ala Arg Thr Leu Gly Glu Phe Leu His Gln Arg Arg Arg Ala Ala 
                165                 170                 175     


Thr Asp Ala Asn His Ile Pro Ser Val Arg Thr Arg Leu Arg Pro Glu 
            180                 185                 190         


Thr Gly Glu Gly Ala Lys Gly Asp Gly Tyr Asp Phe Tyr Pro Ser Arg 
        195                 200                 205             


Ala Leu Ile Ala Glu Glu Phe Glu Glu Ile Trp Ala Ala Gln Ala Pro 
    210                 215                 220                 


His Tyr Pro Asp Thr Leu Thr Gln Gln Val His Asp Arg Leu Tyr Glu 
225                 230                 235                 240 


Ile Ile Phe His Gln Arg Pro Leu Arg Ala Pro Gln Val Gly Gln Cys 
                245                 250                 255     


Thr Leu Val Ala Gly Glu Thr Arg Leu Pro Lys Ala His Pro Leu Phe 
            260                 265                 270         


Gln Lys Arg Arg Leu Leu Glu Glu Ile Asn Ala Leu Met Ile Val Arg 
        275                 280                 285             


Pro Gly Glu Ile Ala Gln Arg Leu Thr Pro Glu Glu Arg Asp Thr Leu 
    290                 295                 300                 


Tyr Leu Lys Leu Lys Asp Lys Arg Thr Val Ser Phe Ala Thr Leu Arg 
305                 310                 315                 320 


Lys Thr Leu Lys Leu Asp Ser Ala Ala Arg Phe Asn Lys Glu Ser Glu 
                325                 330                 335     


Asn Arg Thr Glu Leu Lys Gly Asp Glu Val Ala Ala Glu Leu Gly Ala 
            340                 345                 350         


Lys Thr Arg Leu Gly Thr Arg Trp Gln His Leu Ser Gly Asp Gln Gln 
        355                 360                 365             


Trp Glu Val Val His Arg Leu Met Ala Leu Glu Ser Gln Ala Asp Glu 
    370                 375                 380                 


Ala Ala Phe Arg Asp Trp Ile Ser Gln Thr Tyr Asp Leu Leu Pro Glu 
385                 390                 395                 400 


Gln Ala Ala Ala Val Leu Gly Ala Arg Leu Pro Gln Gly His Gly Arg 
                405                 410                 415     


Phe Gly Pro Thr Ala Thr Thr Thr Leu Ile Asp Ser Leu Leu His Asp 
            420                 425                 430         


Arg Thr Glu Asp Gly Arg Val Val Val Tyr Ser Glu Ala Val Gln Arg 
        435                 440                 445             


Ser Gly Leu Gly His His Ser Asp Leu Arg His Asp Arg Asp Asp Glu 
    450                 455                 460                 


Asp Val Thr Glu Leu Pro Tyr Tyr Gly Val Ala Leu Glu Arg His Ile 
465                 470                 475                 480 


Met Pro Gly Thr Ala Glu Pro Thr Asp Pro Glu Glu Met Arg Ile Gly 
                485                 490                 495     


Arg Leu Thr Asn Pro Thr Val His Ile Gly Leu Asn Gln Leu Arg His 
            500                 505                 510         


Val Val Asn Arg Leu Ile Arg Ala Tyr Gly Pro Pro Lys Glu Ile Ala 
        515                 520                 525             


Ile Glu Leu Ala Arg Glu Leu Lys Leu Ser Glu Asp Glu Lys Lys Lys 
    530                 535                 540                 


Arg Asn Ser Glu Asn Arg Asp Asn Arg Leu Ala Ala Glu Gly Arg Ser 
545                 550                 555                 560 


Lys Lys Leu Glu Glu Ile Arg Gln Arg Asp Thr Gly Ala Asn Arg Ala 
                565                 570                 575     


Leu Leu Lys Leu Trp Glu Glu Leu Asn Pro Gly Asn Val Leu Asp Arg 
            580                 585                 590         


Arg Cys Ile Tyr Thr Gly Glu Gln Ile Ser Ile Asp Met Leu Phe Ser 
        595                 600                 605             


Asp Arg Val Glu Val Asp His Ile Leu Pro Phe Ala Gln Thr Leu Asp 
    610                 615                 620                 


Asp Ser Asn Gly Asn Lys Leu Leu Cys Leu Arg Glu Ala Asn Arg Glu 
625                 630                 635                 640 


Lys Arg Arg Arg Ser Pro Tyr Glu Ala Trp Gly His Thr Asp Arg Trp 
                645                 650                 655     


Pro Asp Ile Ala Glu Arg Ala Ser Arg Leu Pro Lys Pro Lys Arg Trp 
            660                 665                 670         


Arg Phe Glu Pro Asp Ala Met Gln Arg Phe Ala Thr Glu Asp Gly Phe 
        675                 680                 685             


Leu Ala Arg His Leu Val Asp Thr Gln Tyr Leu Gly Arg Leu Ala Arg 
    690                 695                 700                 


Glu Tyr Leu Ser Trp Leu Tyr Pro Gly Arg Gly Glu Gly Ser Gly His 
705                 710                 715                 720 


Val Trp Val Ser Pro Gly Arg Leu Thr Glu Met Val Arg Arg Lys Leu 
                725                 730                 735     


Gly Leu Asn Asp Leu Leu Pro Asp His Asn Phe Gly Gly Gly Ala Asp 
            740                 745                 750         


Gln Pro Lys Asn Arg Leu Asp His Arg His His Ala Ile Asp Ala Leu 
        755                 760                 765             


Val Val Ala Ile Val Asp Arg Gly Met Leu Gln Ala Ile Ala Arg Ala 
    770                 775                 780                 


Ser Gly Gln Asp Gly Ser Glu Gly Arg Glu Arg Ile His Ile Pro Ala 
785                 790                 795                 800 


Pro Trp Asp Gly Phe Arg Asp Asp Leu Arg Val Ala Val Asn Gly Ile 
                805                 810                 815     


Ile Val Ser His Arg Pro Asp His Gly Thr Val Ala Lys Ala Gly Leu 
            820                 825                 830         


Ala Arg Gly Arg Asp Gln Thr Ala Gly Arg Leu His Asn Asp Thr Ala 
        835                 840                 845             


Tyr Gly Leu Thr Gly Glu Thr Asp Ala Lys Gly Asn Ser Ile Val Val 
    850                 855                 860                 


Arg Arg Ile Pro Leu Ser Ala Ile Lys Lys Pro Ala Asp Ile Ala Arg 
865                 870                 875                 880 


Val Arg Asp Pro Leu Leu Arg Asn Ala Leu Ala Glu Phe Thr Lys Gly 
                885                 890                 895     


Leu Asp Gly Lys Ala Phe Glu Ala Arg Ile Gly Arg Phe His Glu Leu 
            900                 905                 910         


Gly Pro Leu Leu Tyr Arg Gly Ile Arg Arg Val Arg Val Val Glu Thr 
        915                 920                 925             


Leu Thr Val Ile Pro Ile Arg Asp Ala Glu Gly Arg Ala Tyr Lys Gly 
    930                 935                 940                 


Tyr Lys Gly Asp Ser Asn Tyr Arg Tyr Asp Val Trp Glu Met Pro Asp 
945                 950                 955                 960 


Gly Lys Trp Arg Cys Gln Val Val Ser Met Phe Asp Ala His Gln Ser 
                965                 970                 975     


Thr Glu Gln Ala Arg Pro His Pro Ala Ala Arg Lys Ile Leu Ser Leu 
            980                 985                 990         


Gln Arg Asn Asp Ile Leu Ala Ile  Glu Arg Thr Glu Gly  Asp Arg Glu 
        995                 1000                 1005             


Leu Val  Arg Val Val Lys Phe  Ser Glu Lys Gln Phe  Ala Val Ala 
    1010                 1015                 1020             


Pro Pro  His Glu Gly Gly Ser  Leu Lys Thr Arg Asp  Gly Asn Ala 
    1025                 1030                 1035             


Asp Asp  Pro Phe Arg Tyr Leu  Tyr Pro Ser Pro Asn  Thr Leu Lys 
    1040                 1045                 1050             


Gly Trp  Arg Ala Arg Gln Val  Arg Ile Asp Glu Leu  Gly Arg Val 
    1055                 1060                 1065             


Leu Asp  Pro Gly Phe Pro Ala  Arg Lys Ser Val Arg  Arg Thr Arg 
    1070                 1075                 1080             


Pro Arg  Ala Ala Pro Val Asp  
    1085                 1090 


<210> 426
<211> 1084
<212> PRT
<213> Sporolactobacillus vineae


<220>
<223> Sporolactobacillus vineae DSM 21990 = SL153

<400> 426
Met Lys Tyr Ser Ile Gly Leu Asp Ile Gly Ile Ser Ser Val Gly Trp 
1               5                   10                  15      


Ser Val Ile Asn Leu Asp Arg Glu Arg Ile Glu Leu Met Gly Ala Arg 
            20                  25                  30          


Leu Phe Asp Ala Ala Glu Asn Pro Lys Asn Gly Ser Ser Leu Ala Ala 
        35                  40                  45              


Pro Arg Arg Asp Ala Arg Ser Ala Arg Arg Arg Leu Arg Arg Arg Arg 
    50                  55                  60                  


Tyr Arg Val Gly Arg Val Arg His Phe Ile Ile Asp Arg Gly Leu Val 
65                  70                  75                  80  


Thr Arg Gly Gln Ala Asp Gln Leu Phe Asp Trp Lys Asp Gly Asp Leu 
                85                  90                  95      


Asp Ile Trp Leu Val Arg Val Asn Ala Leu Glu Arg Leu Leu Thr Asp 
            100                 105                 110         


Arg Glu Phe Ala Arg Val Leu Ile His Ile Ala Lys Asn Arg Gly Tyr 
        115                 120                 125             


Arg Ser Asn Arg Lys Ser Glu Ala Lys Ser Gly Glu Asn Gly Gln Val 
    130                 135                 140                 


Leu Ser Ala Ile Lys Ala Asn Lys Glu Leu Met Glu Glu Lys Gly Tyr 
145                 150                 155                 160 


Gln Thr Val Ala Glu Met Leu Val Asn Glu Pro Glu Thr Phe Ala Gly 
                165                 170                 175     


Arg Lys Arg Asn Arg Gly Gly Glu Tyr Thr His Val Ile Ala Arg Ser 
            180                 185                 190         


Glu Leu Glu His Glu Ile Arg Leu Ile Phe Thr Lys Gln Arg Ala Phe 
        195                 200                 205             


Gly Asn Arg Phe Ala Thr Glu Glu Asn Glu Asn Thr Tyr Val Lys Ile 
    210                 215                 220                 


Trp Ala Ala Gln Arg Pro Val Ala Thr Lys Asp Asp Ile Leu Lys Lys 
225                 230                 235                 240 


Ile Gly Asp Cys Thr Phe Glu Lys Gly Glu Lys Arg Ala Pro Lys Ala 
                245                 250                 255     


Ser Tyr Ala Phe Gln Tyr Phe Arg Ala Leu Asp Lys Leu Asn Arg Leu 
            260                 265                 270         


Arg Ile Leu Ser Val Arg Glu Pro Ser Arg Asn Leu Thr Asp Asp Glu 
        275                 280                 285             


Arg Asn Leu Ile Val Pro Ala Leu Phe Asn His Asp Lys Gln Lys Tyr 
    290                 295                 300                 


Ser Asp Leu Arg Lys Ile Leu Gln Leu Arg Asp Asp Gln Lys Phe Asn 
305                 310                 315                 320 


Glu Leu Phe Tyr Asp Pro Gly Lys Ser Leu Lys Glu Asn Glu Asn Lys 
                325                 330                 335     


Thr Phe Leu Ser Leu Ala Glu Gln Tyr Lys Ile Arg Lys Val Ile Arg 
            340                 345                 350         


Asp Val Gln Gly Lys Asp Gly Leu Leu Gln Tyr Arg Pro Leu Asp Ile 
        355                 360                 365             


Asp Thr Ile Ala Tyr Ala Leu Thr Val Phe Lys Asp Asp Gln Asp Thr 
    370                 375                 380                 


Arg Asp Tyr Leu Ser Asn Thr Phe Val Asn Gly Asn Gly Lys Gln Val 
385                 390                 395                 400 


Leu Asn Leu Ala Asn Arg Ala Phe Asp Ala Glu Leu Ile Asp Gly Leu 
                405                 410                 415     


Leu Ser Leu Ser Phe Ala Lys Phe Gly His Leu Ser Leu Lys Ala Leu 
            420                 425                 430         


His Lys Leu Ile Pro His Met Glu Gln Gly Leu Ser Tyr Tyr Asp Ala 
        435                 440                 445             


Cys Lys Lys Val Gly Tyr His Asp Asn Glu Gln Val Gly Lys Ser Lys 
    450                 455                 460                 


Gln His Leu Leu Pro Val Ile Pro Ala Asp Glu Ile Arg Asn Pro Val 
465                 470                 475                 480 


Val Val Arg Ser Leu Ser Gln Thr Arg Lys Val Ile Asn Ala Ile Ile 
                485                 490                 495     


Lys Arg Tyr Gly Ser Pro Thr Phe Met Tyr Ile Glu Leu Ala Arg Glu 
            500                 505                 510         


Met Gly Arg Pro Tyr Asn Glu Arg Arg Asp Leu Glu Lys Gln Tyr Asn 
        515                 520                 525             


Lys Asn Arg Thr Val Asn Asp Ser Ala Ile Glu Gln Ile His Glu Leu 
    530                 535                 540                 


Tyr Pro Glu Ile Gly Ala Pro Arg Gly His Asp Ile Leu Lys Tyr Lys 
545                 550                 555                 560 


Leu Trp Gln Gln Gln Asp Cys Lys Cys Ala Tyr Ser Leu Glu Lys Ile 
                565                 570                 575     


Pro Ala Glu Lys Ile Phe Glu Pro Gly Tyr Ala Glu Val Asp His Ile 
            580                 585                 590         


Ile Pro Tyr Ser Arg Ser Phe Asp Asp Ser Asn Ser Asn Lys Val Leu 
        595                 600                 605             


Val Leu Ser Arg Met Asn Gln Glu Lys Lys Asn Arg Thr Pro Tyr Glu 
    610                 615                 620                 


Trp Phe Gly Gly Asp Glu His Arg Trp Asn Lys Phe Glu Ser Tyr Val 
625                 630                 635                 640 


Asn Ala Leu Lys Val Asn Arg Lys Lys Lys Ser Leu Leu Thr Lys Lys 
                645                 650                 655     


Asn Met Asp Thr Glu Glu Glu Asp Thr Phe Lys Ser Arg His Leu Asn 
            660                 665                 670         


Asp Thr Arg Tyr Ile Thr Arg Phe Ile Lys Ser Phe Val Glu Asp Asn 
        675                 680                 685             


Leu Leu Phe Arg Glu Ile Glu Gly Ala Lys Gln His Val Phe Thr Val 
    690                 695                 700                 


Asn Gly Ala Tyr Thr Ser Leu Met Arg Lys Arg Trp Gly Phe Asn Lys 
705                 710                 715                 720 


Asn Arg Glu Glu Ser Asp Leu His His Ser Val Asp Ala Val Ile Ile 
                725                 730                 735     


Ala Val Ser Gln Pro Phe Arg Asn Glu Val Ser Arg Tyr Phe Lys His 
            740                 745                 750         


Arg Glu Ile Ser Leu Pro Gln Leu Leu Lys Arg Thr Trp Asp Tyr Phe 
        755                 760                 765             


Pro Glu Pro Trp Glu Gly Phe Val Lys Glu Leu Arg Ala Arg Thr Leu 
    770                 775                 780                 


Gln Asp Pro Glu Lys Leu Lys Leu Ala Leu Glu Ser Leu Asp Leu Asp 
785                 790                 795                 800 


Ser Tyr Asp Pro Glu Phe Ile Asp Glu Val Lys Pro Ile Phe Ile Ser 
                805                 810                 815     


Arg Met Pro Lys Arg Ser Ile Lys Gly Gln Ile His Asp Glu Thr Leu 
            820                 825                 830         


Arg Arg Asn Arg Gly Lys Thr Lys Asp Gly Phe Val Lys Ile Val Thr 
        835                 840                 845             


Arg Thr Arg Leu Glu Asn Ile Lys Phe Asp Lys Asn Gly Asp Phe Pro 
    850                 855                 860                 


Met Tyr Gly Arg Glu Ser Asp Pro Lys Thr Tyr Gln Ala Ile Lys Gln 
865                 870                 875                 880 


Arg Tyr Leu Glu Asn Asn Lys Asp Lys Lys Lys Ala Phe Ile Glu Pro 
                885                 890                 895     


Leu Tyr Lys Pro Ala Lys Asn Pro Asn Asn Ala Ser Leu Ile Arg Ser 
            900                 905                 910         


Val Lys Ile Glu Asp Lys Ala Asn Gln Ile Val Pro Leu Arg Asp Glu 
        915                 920                 925             


Ala Val Ala Tyr Asn Ala Ser Ile Val Arg Thr Glu Val Tyr Arg Asn 
    930                 935                 940                 


Lys Glu Thr Gly Lys Phe Tyr Leu Ala Pro Val Tyr Val Ser Asp Val 
945                 950                 955                 960 


Phe Ala Gly Arg Glu Pro Arg Arg Phe Ile Arg Ala Asn Val Pro Tyr 
                965                 970                 975     


Glu Gln Trp Val Asn Ile Thr Asp Lys Phe Thr Phe Leu Phe Asn Leu 
            980                 985                 990         


Tyr Pro Asn Asp Val Ile Tyr Ile  Lys Met Lys Lys Val  Lys Thr Thr 
        995                 1000                 1005             


Lys Ser  Asn Ile Asn Lys Thr  Ile Ser Trp Gln Glu  Ser Tyr Phe 
    1010                 1015                 1020             


Tyr Phe  Lys Gly Thr Asp Ile  His Thr Gly Ala Ile  Thr Ile Ile 
    1025                 1030                 1035             


Asp His  Met Asn Ser Phe Thr  Asp Arg Val Gly Thr  Gln Gly Leu 
    1040                 1045                 1050             


Gln Leu  Phe Glu Lys Tyr Gln  Val Asp Pro Leu Gly  Asn Leu Ser 
    1055                 1060                 1065             


Arg Val  His Gly Glu Thr Gln  Tyr Gly Val Pro Ala  Leu Ser His 
    1070                 1075                 1080             


Ser 
    


<210> 427
<211> 1053
<212> PRT
<213> Staphylococcus aureus


<220>
<223> Staphylococcus aureus subsp. aureus

<400> 427
Met Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 
    50                  55                  60                  


Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 
65                  70                  75                  80  


Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 
            100                 105                 110         


Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 
        115                 120                 125             


Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala 
    130                 135                 140                 


Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 
145                 150                 155                 160 


Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 
                165                 170                 175     


Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln 
            180                 185                 190         


Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 
        195                 200                 205             


Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 
    210                 215                 220                 


Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 
225                 230                 235                 240 


Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 
                245                 250                 255     


Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 
            260                 265                 270         


Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 
        275                 280                 285             


Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu 
    290                 295                 300                 


Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 
305                 310                 315                 320 


Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 
                325                 330                 335     


Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala 
            340                 345                 350         


Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu 
        355                 360                 365             


Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 
    370                 375                 380                 


Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 
385                 390                 395                 400 


Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 
                405                 410                 415     


Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln 
            420                 425                 430         


Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 
        435                 440                 445             


Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile 
    450                 455                 460                 


Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 
465                 470                 475                 480 


Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys 
                485                 490                 495     


Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 
            500                 505                 510         


Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 
        515                 520                 525             


Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 
    530                 535                 540                 


Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro 
545                 550                 555                 560 


Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys 
                565                 570                 575     


Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu 
            580                 585                 590         


Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile 
        595                 600                 605             


Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 
    610                 615                 620                 


Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 
625                 630                 635                 640 


Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 
                645                 650                 655     


Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys 
            660                 665                 670         


Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp 
        675                 680                 685             


Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp 
    690                 695                 700                 


Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys 
705                 710                 715                 720 


Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys 
                725                 730                 735     


Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu 
            740                 745                 750         


Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp 
        755                 760                 765             


Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu 
785                 790                 795                 800 


Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu 
                805                 810                 815     


Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His 
            820                 825                 830         


Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly 
        835                 840                 845             


Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr 
    850                 855                 860                 


Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile 
865                 870                 875                 880 


Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp 
                885                 890                 895     


Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr 
            900                 905                 910         


Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val 
        915                 920                 925             


Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser 
    930                 935                 940                 


Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala 
945                 950                 955                 960 


Glu Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn Gly 
                965                 970                 975     


Glu Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg Ile 
            980                 985                 990         


Glu Val Asn Met Ile Asp Ile Thr  Tyr Arg Glu Tyr Leu  Glu Asn Met 
        995                 1000                 1005             


Asn Asp  Lys Arg Pro Pro Arg  Ile Ile Lys Thr Ile  Ala Ser Lys 
    1010                 1015                 1020             


Thr Gln  Ser Ile Lys Lys Tyr  Ser Thr Asp Ile Leu  Gly Asn Leu 
    1025                 1030                 1035             


Tyr Glu  Val Lys Ser Lys Lys  His Pro Gln Ile Ile  Lys Lys Gly 
    1040                 1045                 1050             


<210> 428
<211> 1054
<212> PRT
<213> Staphylococcus lugdunensis


<220>
<223> Staphylococcus lugdunensis M23590

<400> 428
Met Asn Gln Lys Phe Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Leu Ile Asp Tyr Glu Thr Lys Asn Ile Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Pro Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ser Arg Arg Leu Lys Arg Arg Arg Ile His Arg Leu 
    50                  55                  60                  


Glu Arg Val Lys Lys Leu Leu Glu Asp Tyr Asn Leu Leu Asp Gln Ser 
65                  70                  75                  80  


Gln Ile Pro Gln Ser Thr Asn Pro Tyr Ala Ile Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Glu Ala Leu Ser Lys Asp Glu Leu Val Ile Ala Leu Leu His Ile 
            100                 105                 110         


Ala Lys Arg Arg Gly Ile His Lys Ile Asp Val Ile Asp Ser Asn Asp 
        115                 120                 125             


Asp Val Gly Asn Glu Leu Ser Thr Lys Glu Gln Leu Asn Lys Asn Ser 
    130                 135                 140                 


Lys Leu Leu Lys Asp Lys Phe Val Cys Gln Ile Gln Leu Glu Arg Met 
145                 150                 155                 160 


Asn Glu Gly Gln Val Arg Gly Glu Lys Asn Arg Phe Lys Thr Ala Asp 
                165                 170                 175     


Ile Ile Lys Glu Ile Ile Gln Leu Leu Asn Val Gln Lys Asn Phe His 
            180                 185                 190         


Gln Leu Asp Glu Asn Phe Ile Asn Lys Tyr Ile Glu Leu Val Glu Met 
        195                 200                 205             


Arg Arg Glu Tyr Phe Glu Gly Pro Gly Lys Gly Ser Pro Tyr Gly Trp 
    210                 215                 220                 


Glu Gly Asp Pro Lys Ala Trp Tyr Glu Thr Leu Met Gly His Cys Thr 
225                 230                 235                 240 


Tyr Phe Pro Asp Glu Leu Arg Ser Val Lys Tyr Ala Tyr Ser Ala Asp 
                245                 250                 255     


Leu Phe Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Gln Arg Asp 
            260                 265                 270         


Gly Leu Ser Lys Leu Glu Tyr His Glu Lys Tyr His Ile Ile Glu Asn 
        275                 280                 285             


Val Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Asn Glu 
    290                 295                 300                 


Ile Asn Val Asn Pro Glu Asp Ile Lys Gly Tyr Arg Ile Thr Lys Ser 
305                 310                 315                 320 


Gly Lys Pro Gln Phe Thr Glu Phe Lys Leu Tyr His Asp Leu Lys Ser 
                325                 330                 335     


Val Leu Phe Asp Gln Ser Ile Leu Glu Asn Glu Asp Val Leu Asp Gln 
            340                 345                 350         


Ile Ala Glu Ile Leu Thr Ile Tyr Gln Asp Lys Asp Ser Ile Lys Ser 
        355                 360                 365             


Lys Leu Thr Glu Leu Asp Ile Leu Leu Asn Glu Glu Asp Lys Glu Asn 
    370                 375                 380                 


Ile Ala Gln Leu Thr Gly Tyr Thr Gly Thr His Arg Leu Ser Leu Lys 
385                 390                 395                 400 


Cys Ile Arg Leu Val Leu Glu Glu Gln Trp Tyr Ser Ser Arg Asn Gln 
                405                 410                 415     


Met Glu Ile Phe Thr His Leu Asn Ile Lys Pro Lys Lys Ile Asn Leu 
            420                 425                 430         


Thr Ala Ala Asn Lys Ile Pro Lys Ala Met Ile Asp Glu Phe Ile Leu 
        435                 440                 445             


Ser Pro Val Val Lys Arg Thr Phe Gly Gln Ala Ile Asn Leu Ile Asn 
    450                 455                 460                 


Lys Ile Ile Glu Lys Tyr Gly Val Pro Glu Asp Ile Ile Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Asn Asn Ser Lys Asp Lys Gln Lys Phe Ile Asn Glu Met 
                485                 490                 495     


Gln Lys Lys Asn Glu Asn Thr Arg Lys Arg Ile Asn Glu Ile Ile Gly 
            500                 505                 510         


Lys Tyr Gly Asn Gln Asn Ala Lys Arg Leu Val Glu Lys Ile Arg Leu 
        515                 520                 525             


His Asp Glu Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ser Ile Pro 
    530                 535                 540                 


Leu Glu Asp Leu Leu Asn Asn Pro Asn His Tyr Glu Val Asp His Ile 
545                 550                 555                 560 


Ile Pro Arg Ser Val Ser Phe Asp Asn Ser Tyr His Asn Lys Val Leu 
                565                 570                 575     


Val Lys Gln Ser Glu Asn Ser Lys Lys Ser Asn Leu Thr Pro Tyr Gln 
            580                 585                 590         


Tyr Phe Asn Ser Gly Lys Ser Lys Leu Ser Tyr Asn Gln Phe Lys Gln 
        595                 600                 605             


His Ile Leu Asn Leu Ser Lys Ser Gln Asp Arg Ile Ser Lys Lys Lys 
    610                 615                 620                 


Lys Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Lys Phe Glu Val Gln 
625                 630                 635                 640 


Lys Glu Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg 
                645                 650                 655     


Glu Leu Thr Asn Tyr Leu Lys Ala Tyr Phe Ser Ala Asn Asn Met Asn 
            660                 665                 670         


Val Lys Val Lys Thr Ile Asn Gly Ser Phe Thr Asp Tyr Leu Arg Lys 
        675                 680                 685             


Val Trp Lys Phe Lys Lys Glu Arg Asn His Gly Tyr Lys His His Ala 
    690                 695                 700                 


Glu Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Leu Phe Lys Glu Asn 
705                 710                 715                 720 


Lys Lys Leu Lys Ala Val Asn Ser Val Leu Glu Lys Pro Glu Ile Glu 
                725                 730                 735     


Ser Lys Gln Leu Asp Ile Gln Val Asp Ser Glu Asp Asn Tyr Ser Glu 
            740                 745                 750         


Met Phe Ile Ile Pro Lys Gln Val Gln Asp Ile Lys Asp Phe Arg Asn 
        755                 760                 765             


Phe Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Gln Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Lys Asp Asn Ser Thr Tyr Ile 
785                 790                 795                 800 


Val Gln Thr Ile Lys Asp Ile Tyr Ala Lys Asp Asn Thr Thr Leu Lys 
                805                 810                 815     


Lys Gln Phe Asp Lys Ser Pro Glu Lys Phe Leu Met Tyr Gln His Asp 
            820                 825                 830         


Pro Arg Thr Phe Glu Lys Leu Glu Val Ile Met Lys Gln Tyr Ala Asn 
        835                 840                 845             


Glu Lys Asn Pro Leu Ala Lys Tyr His Glu Glu Thr Gly Glu Tyr Leu 
    850                 855                 860                 


Thr Lys Tyr Ser Lys Lys Asn Asn Gly Pro Ile Val Lys Ser Leu Lys 
865                 870                 875                 880 


Tyr Ile Gly Asn Lys Leu Gly Ser His Leu Asp Val Thr His Gln Phe 
                885                 890                 895     


Lys Ser Ser Thr Lys Lys Leu Val Lys Leu Ser Ile Lys Pro Tyr Arg 
            900                 905                 910         


Phe Asp Val Tyr Leu Thr Asp Lys Gly Tyr Lys Phe Ile Thr Ile Ser 
        915                 920                 925             


Tyr Leu Asp Val Leu Lys Lys Asp Asn Tyr Tyr Tyr Ile Pro Glu Gln 
    930                 935                 940                 


Lys Tyr Asp Lys Leu Lys Leu Gly Lys Ala Ile Asp Lys Asn Ala Lys 
945                 950                 955                 960 


Phe Ile Ala Ser Phe Tyr Lys Asn Asp Leu Ile Lys Leu Asp Gly Glu 
                965                 970                 975     


Ile Tyr Lys Ile Ile Gly Val Asn Ser Asp Thr Arg Asn Met Ile Glu 
            980                 985                 990         


Leu Asp Leu Pro Asp Ile Arg Tyr  Lys Glu Tyr Cys Glu  Leu Asn Asn 
        995                 1000                 1005             


Ile Lys  Gly Glu Pro Arg Ile  Lys Lys Thr Ile Gly  Lys Lys Val 
    1010                 1015                 1020             


Asn Ser  Ile Glu Lys Leu Thr  Thr Asp Val Leu Gly  Asn Val Phe 
    1025                 1030                 1035             


Thr Asn  Thr Gln Tyr Thr Lys  Pro Gln Leu Leu Phe  Lys Arg Gly 
    1040                 1045                 1050             


Asn 
    


<210> 429
<211> 1334
<212> PRT
<213> Staphylococcus pseudintermedius

<400> 429
Met Gly Arg Lys Pro Tyr Ile Leu Ser Leu Asp Ile Gly Thr Gly Ser 
1               5                   10                  15      


Val Gly Tyr Ala Cys Met Asp Lys Gly Phe Asn Val Leu Lys Tyr His 
            20                  25                  30          


Asp Lys Asp Ala Leu Gly Val Tyr Leu Phe Asp Gly Ala Leu Thr Ala 
        35                  40                  45              


Gln Glu Arg Arg Gln Phe Arg Thr Ser Arg Arg Arg Lys Asn Arg Arg 
    50                  55                  60                  


Ile Lys Arg Leu Gly Leu Leu Gln Glu Leu Leu Ala Pro Leu Val Gln 
65                  70                  75                  80  


Asn Pro Asn Phe Tyr Gln Phe Gln Arg Gln Phe Ala Trp Lys Asn Asp 
                85                  90                  95      


Asn Met Asp Phe Lys Asn Lys Ser Leu Ser Glu Val Leu Ser Phe Leu 
            100                 105                 110         


Gly Tyr Glu Ser Lys Lys Tyr Pro Thr Ile Tyr His Leu Gln Glu Ala 
        115                 120                 125             


Leu Leu Leu Lys Asp Glu Lys Phe Asp Pro Glu Leu Ile Tyr Met Ala 
    130                 135                 140                 


Leu Tyr His Leu Val Lys Tyr Arg Gly His Phe Leu Phe Asp His Leu 
145                 150                 155                 160 


Lys Ile Glu Asn Leu Thr Asn Asn Asp Asn Met His Asp Phe Val Glu 
                165                 170                 175     


Leu Ile Glu Thr Tyr Glu Asn Leu Asn Asn Ile Lys Leu Asn Leu Asp 
            180                 185                 190         


Tyr Glu Lys Thr Lys Val Ile Tyr Glu Ile Leu Lys Asp Asn Glu Met 
        195                 200                 205             


Thr Lys Asn Asp Arg Ala Lys Arg Val Lys Asn Met Glu Lys Lys Leu 
    210                 215                 220                 


Glu Gln Phe Ser Ile Met Leu Leu Gly Leu Lys Phe Asn Glu Gly Lys 
225                 230                 235                 240 


Leu Phe Asn His Ala Asp Asn Ala Glu Glu Leu Lys Gly Ala Asn Gln 
                245                 250                 255     


Ser His Thr Phe Ala Asp Asn Tyr Glu Glu Asn Leu Thr Pro Phe Leu 
            260                 265                 270         


Thr Val Glu Gln Ser Glu Phe Ile Glu Arg Ala Asn Lys Ile Tyr Leu 
        275                 280                 285             


Ser Leu Thr Leu Gln Asp Ile Leu Lys Gly Lys Lys Ser Met Ala Met 
    290                 295                 300                 


Ser Lys Val Ala Ala Tyr Asp Lys Phe Arg Asn Glu Leu Lys Gln Val 
305                 310                 315                 320 


Lys Asp Ile Val Tyr Lys Ala Asp Ser Thr Arg Thr Gln Phe Lys Lys 
                325                 330                 335     


Ile Phe Val Ser Ser Lys Lys Ser Leu Lys Gln Tyr Asp Ala Thr Pro 
            340                 345                 350         


Asn Asp Gln Thr Phe Ser Ser Leu Cys Leu Phe Asp Gln Tyr Leu Ile 
        355                 360                 365             


Arg Pro Lys Lys Gln Tyr Ser Leu Leu Ile Lys Glu Leu Lys Lys Ile 
    370                 375                 380                 


Ile Pro Gln Asp Ser Glu Leu Tyr Phe Glu Ala Glu Asn Asp Thr Leu 
385                 390                 395                 400 


Leu Lys Val Leu Asn Thr Thr Asp Asn Ala Ser Ile Pro Met Gln Ile 
                405                 410                 415     


Asn Leu Tyr Glu Ala Glu Thr Ile Leu Arg Asn Gln Gln Lys Tyr His 
            420                 425                 430         


Ala Glu Ile Thr Asp Glu Met Ile Glu Lys Val Leu Ser Leu Ile Gln 
        435                 440                 445             


Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Val Asn Asp His Thr Ala 
    450                 455                 460                 


Ser Lys Phe Gly Trp Met Glu Arg Lys Ser Asn Glu Ser Ile Lys Pro 
465                 470                 475                 480 


Trp Asn Phe Asp Glu Val Val Asp Arg Ser Lys Ser Ala Thr Gln Phe 
                485                 490                 495     


Ile Arg Arg Met Thr Asn Lys Cys Ser Tyr Leu Ile Asn Glu Asp Val 
            500                 505                 510         


Leu Pro Lys Asn Ser Leu Leu Tyr Gln Glu Met Glu Val Leu Asn Glu 
        515                 520                 525             


Leu Asn Ala Thr Gln Ile Arg Leu Gln Thr Asp Pro Lys Asn Arg Lys 
    530                 535                 540                 


Tyr Arg Met Met Pro Gln Ile Lys Leu Phe Ala Val Glu His Ile Phe 
545                 550                 555                 560 


Lys Lys Tyr Lys Thr Val Ser His Ser Lys Phe Leu Glu Ile Met Leu 
                565                 570                 575     


Asn Ser Asn His Arg Glu Asn Phe Met Asn His Gly Glu Lys Leu Ser 
            580                 585                 590         


Ile Phe Gly Thr Gln Asp Asp Lys Lys Phe Ala Ser Lys Leu Ser Ser 
        595                 600                 605             


Tyr Gln Asp Met Thr Lys Ile Phe Gly Asp Ile Glu Gly Lys Arg Ala 
    610                 615                 620                 


Gln Ile Glu Glu Ile Ile Gln Trp Ile Thr Ile Phe Glu Asp Lys Lys 
625                 630                 635                 640 


Ile Leu Val Gln Lys Leu Lys Glu Cys Tyr Pro Glu Leu Thr Ser Lys 
                645                 650                 655     


Gln Ile Asn Gln Leu Lys Lys Leu Asn Tyr Ser Gly Trp Gly Arg Leu 
            660                 665                 670         


Ser Glu Lys Leu Leu Thr His Ala Tyr Gln Gly His Ser Ile Ile Glu 
        675                 680                 685             


Leu Leu Arg His Ser Asp Glu Asn Phe Met Glu Ile Leu Thr Asn Asp 
    690                 695                 700                 


Val Tyr Gly Phe Gln Asn Phe Ile Lys Glu Glu Asn Gln Val Gln Ser 
705                 710                 715                 720 


Asn Lys Ile Gln His Gln Asp Ile Ala Asn Leu Thr Thr Ser Pro Ala 
                725                 730                 735     


Leu Lys Lys Gly Ile Trp Ser Thr Ile Lys Leu Val Arg Glu Leu Thr 
            740                 745                 750         


Ser Ile Phe Gly Glu Pro Glu Lys Ile Ile Met Glu Phe Ala Thr Glu 
        755                 760                 765             


Asp Gln Gln Lys Gly Lys Lys Gln Lys Ser Arg Lys Gln Leu Trp Asp 
    770                 775                 780                 


Asp Asn Ile Lys Lys Asn Lys Leu Lys Ser Val Asp Glu Tyr Lys Tyr 
785                 790                 795                 800 


Ile Ile Asp Val Ala Asn Lys Leu Asn Asn Glu Gln Leu Gln Gln Glu 
                805                 810                 815     


Lys Leu Trp Leu Tyr Leu Ser Gln Asn Gly Lys Cys Met Tyr Ser Gly 
            820                 825                 830         


Gln Ser Ile Asp Leu Asp Ala Leu Leu Ser Pro Asn Ala Thr Lys His 
        835                 840                 845             


Tyr Glu Val Asp His Ile Phe Pro Arg Ser Phe Ile Lys Asp Asp Ser 
    850                 855                 860                 


Ile Asp Asn Lys Val Leu Val Ile Lys Lys Met Asn Gln Thr Lys Gly 
865                 870                 875                 880 


Asp Gln Val Pro Leu Gln Phe Ile Gln Gln Pro Tyr Glu Arg Ile Ala 
                885                 890                 895     


Tyr Trp Lys Ser Leu Asn Lys Ala Gly Leu Ile Ser Asp Ser Lys Leu 
            900                 905                 910         


His Lys Leu Met Lys Pro Glu Phe Thr Ala Met Asp Lys Glu Gly Phe 
        915                 920                 925             


Ile Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Ser Val His Val Arg 
    930                 935                 940                 


Asp Phe Leu Lys Glu Glu Tyr Pro Asn Thr Lys Val Ile Pro Met Lys 
945                 950                 955                 960 


Ala Lys Met Val Ser Glu Phe Arg Lys Lys Phe Asp Ile Pro Lys Ile 
                965                 970                 975     


Arg Gln Met Asn Asp Ala His His Ala Ile Asp Ala Tyr Leu Asn Gly 
            980                 985                 990         


Val Val Tyr His Gly Ala Gln Leu  Ala Tyr Pro Asn Val  Asp Leu Phe 
        995                 1000                 1005             


Asp Phe  Asn Phe Lys Trp Glu  Lys Val Arg Glu Lys  Trp Lys Ala 
    1010                 1015                 1020             


Leu Gly  Glu Phe Asn Thr Lys  Gln Lys Ser Arg Glu  Leu Phe Phe 
    1025                 1030                 1035             


Phe Lys  Lys Leu Glu Lys Met  Glu Val Ser Gln Gly  Glu Arg Leu 
    1040                 1045                 1050             


Ile Ser  Lys Ile Lys Leu Asp  Met Asn His Phe Lys  Ile Asn Tyr 
    1055                 1060                 1065             


Ser Arg  Lys Leu Ala Asn Ile  Pro Gln Gln Phe Tyr  Asn Gln Thr 
    1070                 1075                 1080             


Ala Val  Ser Pro Lys Thr Ala  Glu Leu Lys Tyr Glu  Ser Asn Lys 
    1085                 1090                 1095             


Ser Asn  Glu Val Val Tyr Lys  Gly Leu Thr Pro Tyr  Gln Thr Tyr 
    1100                 1105                 1110             


Val Val  Ala Ile Lys Ser Val  Asn Lys Lys Gly Lys  Glu Lys Met 
    1115                 1120                 1125             


Glu Tyr  Gln Met Ile Asp His  Tyr Val Phe Asp Phe  Tyr Lys Phe 
    1130                 1135                 1140             


Gln Asn  Gly Asn Glu Lys Glu  Leu Ala Leu Tyr Leu  Ala Gln Arg 
    1145                 1150                 1155             


Glu Asn  Lys Asp Glu Val Leu  Asp Ala Gln Ile Val  Tyr Ser Leu 
    1160                 1165                 1170             


Asn Lys  Gly Asp Leu Leu Tyr  Ile Asn Asn His Pro  Cys Tyr Phe 
    1175                 1180                 1185             


Val Ser  Arg Lys Glu Val Ile  Asn Ala Lys Gln Phe  Glu Leu Thr 
    1190                 1195                 1200             


Val Glu  Gln Gln Leu Ser Leu  Tyr Asn Val Met Asn  Asn Lys Glu 
    1205                 1210                 1215             


Thr Asn  Val Glu Lys Leu Leu  Ile Glu Tyr Asp Phe  Ile Ala Glu 
    1220                 1225                 1230             


Lys Val  Ile Asn Glu Tyr His  His Tyr Leu Asn Ser  Lys Leu Lys 
    1235                 1240                 1245             


Glu Lys  Arg Val Arg Thr Phe  Phe Ser Glu Ser Asn  Gln Thr His 
    1250                 1255                 1260             


Glu Asp  Phe Ile Lys Ala Leu  Asp Glu Leu Phe Lys  Val Val Thr 
    1265                 1270                 1275             


Ala Ser  Ala Thr Arg Ser Asp  Lys Ile Gly Ser Arg  Lys Asn Ser 
    1280                 1285                 1290             


Met Thr  His Arg Ala Phe Leu  Gly Lys Gly Lys Asp  Val Lys Ile 
    1295                 1300                 1305             


Ala Tyr  Thr Ser Ile Ser Gly  Leu Lys Thr Thr Lys  Pro Lys Ser 
    1310                 1315                 1320             


Leu Phe  Lys Leu Ala Glu Ser  Arg Asn Glu Leu 
    1325                 1330                 


<210> 430
<211> 1334
<212> PRT
<213> Staphylococcus pseudintermedius


<220>
<223> Staphylococcus pseudintermedius ED99

<400> 430
Met Gly Arg Lys Pro Tyr Ile Leu Ser Leu Asp Ile Gly Thr Gly Ser 
1               5                   10                  15      


Val Gly Tyr Ala Cys Met Asp Lys Gly Phe Asn Val Leu Lys Tyr His 
            20                  25                  30          


Asp Lys Asp Ala Leu Gly Val Tyr Leu Phe Asp Gly Ala Leu Thr Ala 
        35                  40                  45              


Gln Glu Arg Arg Gln Phe Arg Thr Ser Arg Arg Arg Lys Asn Arg Arg 
    50                  55                  60                  


Ile Lys Arg Leu Gly Leu Leu Gln Glu Leu Leu Ala Pro Leu Val Gln 
65                  70                  75                  80  


Asn Pro Asn Phe Tyr Gln Phe Gln Arg Gln Phe Ala Trp Lys Asn Asp 
                85                  90                  95      


Asn Met Asp Phe Lys Asn Lys Ser Leu Ser Glu Val Leu Ser Phe Leu 
            100                 105                 110         


Gly Tyr Glu Ser Lys Lys Tyr Pro Thr Ile Tyr His Leu Gln Glu Ala 
        115                 120                 125             


Leu Leu Leu Lys Asp Glu Lys Phe Asp Pro Glu Leu Ile Tyr Met Ala 
    130                 135                 140                 


Leu Tyr His Leu Val Lys Tyr Arg Gly His Phe Leu Phe Asp His Leu 
145                 150                 155                 160 


Lys Ile Glu Asn Leu Thr Asn Asn Asp Asn Met His Asp Phe Val Glu 
                165                 170                 175     


Leu Ile Glu Thr Tyr Glu Asn Leu Asn Asn Ile Lys Leu Asn Leu Asp 
            180                 185                 190         


Tyr Glu Lys Thr Lys Val Ile Tyr Glu Ile Leu Lys Asp Asn Glu Met 
        195                 200                 205             


Thr Lys Asn Asp Arg Ala Lys Arg Val Lys Asn Met Glu Lys Lys Leu 
    210                 215                 220                 


Glu Gln Phe Ser Ile Met Leu Leu Gly Leu Lys Phe Asn Glu Gly Lys 
225                 230                 235                 240 


Leu Phe Asn His Ala Asp Asn Ala Glu Glu Leu Lys Gly Ala Asn Gln 
                245                 250                 255     


Ser His Thr Phe Ala Asp Asn Tyr Glu Glu Asn Leu Thr Pro Phe Leu 
            260                 265                 270         


Thr Val Glu Gln Ser Glu Phe Ile Glu Arg Ala Asn Lys Ile Tyr Leu 
        275                 280                 285             


Ser Leu Thr Leu Gln Asp Ile Leu Lys Gly Lys Lys Ser Met Ala Met 
    290                 295                 300                 


Ser Lys Val Ala Ala Tyr Asp Lys Phe Arg Asn Glu Leu Lys Gln Val 
305                 310                 315                 320 


Lys Asp Ile Val Tyr Lys Ala Asp Ser Thr Arg Thr Gln Phe Lys Lys 
                325                 330                 335     


Ile Phe Val Ser Ser Lys Lys Ser Leu Lys Gln Tyr Asp Ala Thr Pro 
            340                 345                 350         


Asn Asp Gln Thr Phe Ser Ser Leu Cys Leu Phe Asp Gln Tyr Leu Ile 
        355                 360                 365             


Arg Pro Lys Lys Gln Tyr Ser Leu Leu Ile Lys Glu Leu Lys Lys Ile 
    370                 375                 380                 


Ile Pro Gln Asp Ser Glu Leu Tyr Phe Glu Ala Glu Asn Asp Thr Leu 
385                 390                 395                 400 


Leu Lys Val Leu Asn Thr Thr Asp Asn Ala Ser Ile Pro Met Gln Ile 
                405                 410                 415     


Asn Leu Tyr Glu Ala Glu Thr Ile Leu Arg Asn Gln Gln Lys Tyr His 
            420                 425                 430         


Ala Glu Ile Thr Asp Glu Met Ile Glu Lys Val Leu Ser Leu Ile Gln 
        435                 440                 445             


Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Val Asn Asp His Thr Ala 
    450                 455                 460                 


Ser Lys Phe Gly Trp Met Glu Arg Lys Ser Asn Glu Ser Ile Lys Pro 
465                 470                 475                 480 


Trp Asn Phe Asp Glu Val Val Asp Arg Ser Lys Ser Ala Thr Gln Phe 
                485                 490                 495     


Ile Arg Arg Met Thr Asn Lys Cys Ser Tyr Leu Ile Asn Glu Asp Val 
            500                 505                 510         


Leu Pro Lys Asn Ser Leu Leu Tyr Gln Glu Met Glu Val Leu Asn Glu 
        515                 520                 525             


Leu Asn Ala Thr Gln Ile Arg Leu Gln Thr Asp Pro Lys Asn Arg Lys 
    530                 535                 540                 


Tyr Arg Met Met Pro Gln Ile Lys Leu Phe Ala Val Glu His Ile Phe 
545                 550                 555                 560 


Lys Lys Tyr Lys Thr Val Ser His Ser Lys Phe Leu Glu Ile Met Leu 
                565                 570                 575     


Asn Ser Asn His Arg Glu Asn Phe Met Asn His Gly Glu Lys Leu Ser 
            580                 585                 590         


Ile Phe Gly Thr Gln Asp Asp Lys Lys Phe Ala Ser Lys Leu Ser Ser 
        595                 600                 605             


Tyr Gln Asp Met Thr Lys Ile Phe Gly Asp Ile Glu Gly Lys Arg Ala 
    610                 615                 620                 


Gln Ile Glu Glu Ile Ile Gln Trp Ile Thr Ile Phe Glu Asp Lys Lys 
625                 630                 635                 640 


Ile Leu Val Gln Lys Leu Lys Glu Cys Tyr Pro Glu Leu Thr Ser Lys 
                645                 650                 655     


Gln Ile Asn Gln Leu Lys Lys Leu Asn Tyr Ser Gly Trp Gly Arg Leu 
            660                 665                 670         


Ser Glu Lys Leu Leu Thr His Ala Tyr Gln Gly His Ser Ile Ile Glu 
        675                 680                 685             


Leu Leu Arg His Ser Asp Glu Asn Phe Met Glu Ile Leu Thr Asn Asp 
    690                 695                 700                 


Val Tyr Gly Phe Gln Asn Phe Ile Lys Glu Glu Asn Gln Val Gln Ser 
705                 710                 715                 720 


Asn Lys Ile Gln His Gln Asp Ile Ala Asn Leu Thr Thr Ser Pro Ala 
                725                 730                 735     


Leu Lys Lys Gly Ile Trp Ser Thr Ile Lys Leu Val Arg Glu Leu Thr 
            740                 745                 750         


Ser Ile Phe Gly Glu Pro Glu Lys Ile Ile Met Glu Phe Ala Thr Glu 
        755                 760                 765             


Asp Gln Gln Lys Gly Lys Lys Gln Lys Ser Arg Lys Gln Leu Trp Asp 
    770                 775                 780                 


Asp Asn Ile Lys Lys Asn Lys Leu Lys Ser Val Asp Glu Tyr Lys Tyr 
785                 790                 795                 800 


Ile Ile Asp Val Ala Asn Lys Leu Asn Asn Glu Gln Leu Gln Gln Glu 
                805                 810                 815     


Lys Leu Trp Leu Tyr Leu Ser Gln Asn Gly Lys Cys Met Tyr Ser Gly 
            820                 825                 830         


Gln Ser Ile Asp Leu Asp Ala Leu Leu Ser Pro Asn Ala Thr Lys His 
        835                 840                 845             


Tyr Glu Val Asp His Ile Phe Pro Arg Ser Phe Ile Lys Asp Asp Ser 
    850                 855                 860                 


Ile Asp Asn Lys Val Leu Val Ile Lys Lys Met Asn Gln Thr Lys Gly 
865                 870                 875                 880 


Asp Gln Val Pro Leu Gln Phe Ile Gln Gln Pro Tyr Glu Arg Ile Ala 
                885                 890                 895     


Tyr Trp Lys Ser Leu Asn Lys Ala Gly Leu Ile Ser Asp Ser Lys Leu 
            900                 905                 910         


His Lys Leu Met Lys Pro Glu Phe Thr Ala Met Asp Lys Glu Gly Phe 
        915                 920                 925             


Ile Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Ser Val His Val Arg 
    930                 935                 940                 


Asp Phe Leu Lys Glu Glu Tyr Pro Asn Thr Lys Val Ile Pro Met Lys 
945                 950                 955                 960 


Ala Lys Met Val Ser Glu Phe Arg Lys Lys Phe Asp Ile Pro Lys Ile 
                965                 970                 975     


Arg Gln Met Asn Asp Ala His His Ala Ile Asp Ala Tyr Leu Asn Gly 
            980                 985                 990         


Val Val Tyr His Gly Ala Gln Leu  Ala Tyr Pro Asn Val  Asp Leu Phe 
        995                 1000                 1005             


Asp Phe  Asn Phe Lys Trp Glu  Lys Val Arg Glu Lys  Trp Lys Ala 
    1010                 1015                 1020             


Leu Gly  Glu Phe Asn Thr Lys  Gln Lys Ser Arg Glu  Leu Phe Phe 
    1025                 1030                 1035             


Phe Lys  Lys Leu Glu Lys Met  Glu Val Ser Gln Gly  Glu Arg Leu 
    1040                 1045                 1050             


Ile Ser  Lys Ile Lys Leu Asp  Met Asn His Phe Lys  Ile Asn Tyr 
    1055                 1060                 1065             


Ser Arg  Lys Leu Ala Asn Ile  Pro Gln Gln Phe Tyr  Asn Gln Thr 
    1070                 1075                 1080             


Ala Val  Ser Pro Lys Thr Ala  Glu Leu Lys Tyr Glu  Ser Asn Lys 
    1085                 1090                 1095             


Ser Asn  Glu Val Val Tyr Lys  Gly Leu Thr Pro Tyr  Gln Thr Tyr 
    1100                 1105                 1110             


Val Val  Ala Ile Lys Ser Val  Asn Lys Lys Gly Lys  Glu Lys Met 
    1115                 1120                 1125             


Glu Tyr  Gln Met Ile Asp His  Tyr Val Phe Asp Phe  Tyr Lys Phe 
    1130                 1135                 1140             


Gln Asn  Gly Asn Glu Lys Glu  Leu Ala Leu Tyr Leu  Ala Gln Arg 
    1145                 1150                 1155             


Glu Asn  Lys Asp Glu Val Leu  Asp Ala Gln Ile Val  Tyr Ser Leu 
    1160                 1165                 1170             


Asn Lys  Gly Asp Leu Leu Tyr  Ile Asn Asn His Pro  Cys Tyr Phe 
    1175                 1180                 1185             


Val Ser  Arg Lys Glu Val Ile  Asn Ala Lys Gln Phe  Glu Leu Thr 
    1190                 1195                 1200             


Val Glu  Gln Gln Leu Ser Leu  Tyr Asn Val Met Asn  Asn Lys Glu 
    1205                 1210                 1215             


Thr Asn  Val Glu Lys Leu Leu  Ile Glu Tyr Asp Phe  Ile Ala Glu 
    1220                 1225                 1230             


Lys Val  Ile Asn Glu Tyr His  His Tyr Leu Asn Ser  Lys Leu Lys 
    1235                 1240                 1245             


Glu Lys  Arg Val Arg Thr Phe  Phe Ser Glu Ser Asn  Gln Thr His 
    1250                 1255                 1260             


Glu Asp  Phe Ile Lys Ala Leu  Asp Glu Leu Phe Lys  Val Val Thr 
    1265                 1270                 1275             


Ala Ser  Ala Thr Arg Ser Asp  Lys Ile Gly Ser Arg  Lys Asn Ser 
    1280                 1285                 1290             


Met Thr  His Arg Ala Phe Leu  Gly Lys Gly Lys Asp  Val Lys Ile 
    1295                 1300                 1305             


Ala Tyr  Thr Ser Ile Ser Gly  Leu Lys Thr Thr Lys  Pro Lys Ser 
    1310                 1315                 1320             


Leu Phe  Lys Leu Ala Glu Ser  Arg Asn Glu Leu 
    1325                 1330                 


<210> 431
<211> 1112
<212> PRT
<213> Staphylococcus simulans


<220>
<223> Staphylococcus simulans ACS-120-V-Sch1

<400> 431
Met Leu Val Gly Leu Lys Phe Lys Gln Ser Ile Leu Phe Glu Asn Met 
1               5                   10                  15      


Glu Asn Ala Glu Asp Ile Lys Glu Ser Ala Thr Gly Ser Asp Ala Ile 
            20                  25                  30          


Ser Leu Ser Asp Asp Tyr Tyr Glu Asn Leu Ser Glu Phe Leu Thr Asp 
        35                  40                  45              


Glu Gln Leu Asn Phe Ile Glu Ser Ala Asn Thr Phe Phe Met Gly Ile 
    50                  55                  60                  


Met Leu Asp Arg Ile Leu Lys Gly Ala Thr Ser Ile Ser Ala Ala Lys 
65                  70                  75                  80  


Val Arg Asp Tyr Lys Ile Phe Lys Ser Gln Leu Lys Leu Ile Lys Asp 
                85                  90                  95      


Ile Val Tyr Gln Asn Lys Tyr Asp Lys Tyr His Glu Phe Phe Val Thr 
            100                 105                 110         


Ser Lys Glu Asp Met Arg Ala Tyr Gln Glu Asn Pro Asp Ala Lys Asn 
        115                 120                 125             


Phe Gly Lys Leu Ser Lys Phe Asp Gln Tyr Leu Ile His Ser Lys Asp 
    130                 135                 140                 


Gln Tyr Ala Lys Leu Met Lys Asp Leu Lys Gly Leu Val Pro Lys Glu 
145                 150                 155                 160 


Tyr Thr Glu Val Leu Asn Leu Ile Asp Glu Gln Lys Phe Leu Val Val 
                165                 170                 175     


Gln Asn Thr Thr Asp Asn Ala Ser Ile Pro Tyr Gln Asn Asn Val Phe 
            180                 185                 190         


Glu Ala Glu Asn Ile Leu Arg Asn Gln Gln Lys Tyr Tyr Pro Glu Ile 
        195                 200                 205             


Thr Glu Glu Met Ile Gly Lys Val Ile Asn Leu Ile Ser Phe Arg Ile 
    210                 215                 220                 


Pro Tyr Tyr Val Gly Pro Leu Thr Asn Lys Asn Gly Gln Ser Asp Phe 
225                 230                 235                 240 


Ala Trp Met Ile Arg Lys Ser Asp Glu Gln Thr Leu Pro Trp Asn Phe 
                245                 250                 255     


Asp Lys Val Ile Asp Lys Ser Lys Ser Ala Glu Lys Phe Ile Arg Arg 
            260                 265                 270         


Met Thr Ser Lys Cys Thr Tyr Leu Leu Glu Glu Asp Val Leu Pro Lys 
        275                 280                 285             


His Ser Leu Leu Tyr Gln Glu Met Glu Val Leu Asn Glu Leu Asn Asn 
    290                 295                 300                 


Val Gln Leu Arg Gly Glu Asn Glu Pro Lys His Arg Ile His Arg Leu 
305                 310                 315                 320 


Asp Pro Lys Val Lys Gln Phe Ile Tyr His Asn Leu Phe Gln Lys Lys 
                325                 330                 335     


Lys Asn Val Thr His Lys Asp Leu Ile Thr Leu Leu Gln Asn Ser Glu 
            340                 345                 350         


His Arg Asn Thr Leu Asn Lys Thr Ser Gly Gln Lys Leu Lys Val Phe 
        355                 360                 365             


Gly Thr Gln Asn Asp Ser Lys Phe Ala Ser Lys Leu Ser Thr Tyr Asn 
    370                 375                 380                 


Asp Met Lys Ala Ile Leu Gly Ser Val Glu Asn Lys Arg Gln Met Ile 
385                 390                 395                 400 


Glu Glu Leu Val Leu Trp Ile Thr Ile Phe Glu Asp Lys Ala Ile Leu 
                405                 410                 415     


Lys Gln Lys Ile Gly Glu Lys Tyr Pro Asn Ile Thr Glu Lys Gln Leu 
            420                 425                 430         


Asn Gln Ile Val Lys Leu Asn Tyr Ser Gly Trp Gly Arg Leu Ser Glu 
        435                 440                 445             


Lys Leu Leu Thr Lys Glu Val Asn Gly Arg Ser Leu Ile Asp Leu Met 
    450                 455                 460                 


Tyr Ser Thr Glu Asn Asn Phe Met Glu Ile Ile Thr Asp Lys Thr Leu 
465                 470                 475                 480 


Gly Phe Asp Cys Phe Ile Lys Asn Ser Asn Lys Val Lys Asn Ala Lys 
                485                 490                 495     


Ile Ser Tyr Lys Asp Val Ala Glu Leu Arg Thr Ser Pro Ala Leu Lys 
            500                 505                 510         


Lys Gly Ile Trp Asn Ala Ile Lys Met Val Arg Glu Ile Ser Asn Leu 
        515                 520                 525             


Phe Gly Ala Pro Glu Lys Ile Ile Ile Glu Phe Ala Thr Glu Asp Gln 
    530                 535                 540                 


Ala Lys Gly Lys Arg Gln Lys Ser Arg Ser Glu Leu Trp Asp Asp Leu 
545                 550                 555                 560 


Val Lys Lys Asn Asn Leu Lys Arg Asn Lys Glu Phe Glu Gly Leu Phe 
                565                 570                 575     


Glu Glu Leu Lys Ala Tyr Pro Asp Leu Asp Phe Ser Asn Pro Lys Leu 
            580                 585                 590         


Trp Leu Tyr Ile His Gln Asn Gly Lys Cys Met Tyr Thr Lys Lys Pro 
        595                 600                 605             


Ile Asp Leu Glu Arg Leu Met Ser Asp Thr Asn Asn Gln Leu Tyr Glu 
    610                 615                 620                 


Ile Asp His Ile Leu Pro Arg Thr Phe Val Lys Asp Asp Ser Ile Asn 
625                 630                 635                 640 


Asn Lys Val Leu Val Ile Gln Ser Ala Asn Gln Lys Lys Ser Gly Asp 
                645                 650                 655     


Lys Met Pro Leu Glu Ile Phe Asp Asn His Val Leu Val Pro Phe Trp 
            660                 665                 670         


Lys Met Leu Tyr Glu Asn Asp Leu Ile Ser Ser Ser Lys Leu Ser Lys 
        675                 680                 685             


Leu Met Lys Lys Glu Phe Asn Asp Leu Asp Lys Glu Gly Phe Ile Gln 
    690                 695                 700                 


Arg Gln Leu Val Glu Thr Arg Gln Ile Ile Ser His Val Ser Asp Phe 
705                 710                 715                 720 


Leu Thr Glu Glu Tyr Pro Ser Thr Thr Val Val Pro Met Lys Ala Asn 
                725                 730                 735     


Val Val Ser Glu Leu Arg Arg Lys Phe Asp Ile Pro Lys Ile Arg Gln 
            740                 745                 750         


Leu Asn Asp Trp His His Ala Val Asp Ala Tyr Leu Asn Gly Phe Val 
        755                 760                 765             


Tyr Gln Ala Ala Arg Val Phe Tyr Pro Lys Val Asn Leu Phe Glu Phe 
    770                 775                 780                 


Asn Phe Lys Trp Glu Lys Val Arg Glu Lys Trp Arg Gln Leu Gly Glu 
785                 790                 795                 800 


Phe Thr Glu Asn Asn Lys Lys Arg Glu Phe Phe Leu Phe Lys Arg Met 
                805                 810                 815     


Glu Asn Tyr Val Asn Glu Tyr Gly Glu Gly Met Ile Ser Lys Leu Ile 
            820                 825                 830         


Phe Asp Leu Asp Asn Phe Lys Phe Asn Tyr Ser Arg Lys Val Glu Ser 
        835                 840                 845             


Thr Glu Ser Ala Phe Tyr Lys Gln Ser Ala Phe Ser Pro Lys Asn Thr 
    850                 855                 860                 


Thr Ala Gln Tyr Asp Ser Asp Lys Asn Lys Thr Ala Ile Tyr Lys Glu 
865                 870                 875                 880 


Met Lys Asn Lys Arg Gly Ile Val Val Ser Tyr Thr Tyr Val Lys Lys 
                885                 890                 895     


Asp Gln Glu Leu Ile Gly Tyr Gly Val Phe Asn Glu Thr Val Phe Glu 
            900                 905                 910         


Tyr Val Asn Asn Ala Asp Val Asp Met Asn Thr Arg Ala Leu Lys Ile 
        915                 920                 925             


Val Arg Lys Ala Phe Pro Lys Leu Asp Ile Lys Lys Ala Gln Tyr Leu 
    930                 935                 940                 


Phe Ser Ile Asn Lys Gly Asp Ala Leu Leu Val Asn Gly His Pro Phe 
945                 950                 955                 960 


Leu Phe Val Ser Ala Tyr Glu Arg Ile Asn Gly Lys Gln Leu Glu Phe 
                965                 970                 975     


Asp Ile Ala Met Gln Arg Lys Ile Lys Gln Ala Leu Ser Pro Tyr Asn 
            980                 985                 990         


Asn Met Thr Glu Gln Glu Lys Val  Glu Phe Tyr Asn Gln  Phe Ala Glu 
        995                 1000                 1005             


Lys Val  Ile Glu Glu Phe Arg  Asn Ser Ile Gly Leu  Gln Ser Arg 
    1010                 1015                 1020             


Asp Arg  Lys Val Asn Leu Ile  Lys Asn Leu Phe Asn  Asn Thr Glu 
    1025                 1030                 1035             


Lys Ser  Asn Asp Ser Met Thr  Gln Ser Ile Leu Glu  Val Leu Lys 
    1040                 1045                 1050             


Met Thr  Lys Val Ser Ala Glu  Arg Ser Lys Glu Leu  Lys Ile Arg 
    1055                 1060                 1065             


Trp Asn  Gly Gln Thr Pro Asn  Thr Phe Ile Asp Thr  Lys Asn Asn 
    1070                 1075                 1080             


Ala Glu  Ile Gln Tyr Lys Ser  Ile Thr Gly Leu Lys  Thr Thr Lys 
    1085                 1090                 1095             


Pro Lys  Ser Ile Phe Lys Leu  Ala Glu Ser Lys Asn  Glu Leu 
    1100                 1105                 1110         


<210> 432
<211> 1370
<212> PRT
<213> Streptococcus agalactiae


<220>
<223> Streptococcus agalactiae 2603V/R

<400> 432
Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Ser Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Ser Lys Gln Tyr Gln Asp Phe Leu Glu Ile 
            180                 185                 190         


Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys Tyr 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Asn  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Ala Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210> 433
<211> 1377
<212> PRT
<213> Streptococcus agalactiae


<220>
<223> Streptococcus agalactiae 515

<400> 433
Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Tyr Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Arg Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Lys Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Thr Phe Glu Asn Asn His Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Val Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His His Glu Asp Leu Lys His Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Asn Tyr Arg Glu Val Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Leu Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Gly Ser Glu Tyr Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Arg Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Phe Leu Ala Glu Gly Phe Lys Asp Phe Gln Phe Leu Asn Arg Lys 
    530                 535                 540                 


Gln Lys Glu Thr Ile Phe Asn Ser Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile Ser Phe Leu Asn Lys Val Asp Gly Tyr Glu 
                565                 570                 575     


Gly Ile Ala Ile Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Lys Lys Ile Leu Gly Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Thr Asp Asn Glu Leu Ile Leu Glu Asp Ile Val Gln Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Lys Lys Cys Leu Asp Ile Tyr Lys Asp 
625                 630                 635                 640 


Phe Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asn Lys 
            660                 665                 670         


Glu Asn Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ser Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Asp Leu Ser Phe Lys 
    690                 695                 700                 


Pro Ile Ile Asp Lys Ala Arg Thr Gly Ser His Ser Asp Asn Leu Lys 
705                 710                 715                 720 


Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val Met Gly Tyr 
            740                 745                 750         


Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr 
        755                 760                 765             


Ala Lys Gly Leu Ser Arg Ser Arg Gln Arg Leu Thr Thr Leu Arg Glu 
    770                 775                 780                 


Ser Leu Ala Asn Leu Lys Ser Asn Ile Leu Glu Glu Lys Lys Pro Lys 
785                 790                 795                 800 


Tyr Val Lys Asp Gln Val Glu Asn His His Leu Ser Asp Asp Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Lys Lys Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Ile Glu Ile 
865                 870                 875                 880 


Val Lys Ala Arg Lys Met Phe Trp Lys Asn Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Val Asp Asn Gly Lys Lys Ile Cys Lys Val Lys Ile Val 
945                 950                 955                 960 


Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly Phe 
                965                 970                 975     


Tyr Lys Ile Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala Tyr 
            980                 985                 990         


Leu Asn Ala Val Val Ala Lys Ala  Ile Leu Thr Lys Tyr  Pro Gln Leu 
        995                 1000                 1005             


Glu Pro  Glu Phe Val Tyr Gly  Met Tyr Arg Gln Lys  Lys Leu Ser 
    1010                 1015                 1020             


Lys Ile  Val His Glu Asp Lys  Glu Glu Lys Tyr Ser  Glu Ala Thr 
    1025                 1030                 1035             


Arg Lys  Met Phe Phe Tyr Ser  Asn Leu Met Asn Met  Phe Lys Arg 
    1040                 1045                 1050             


Val Val  Arg Leu Ala Asp Gly  Ser Ile Val Val Arg  Pro Val Ile 
    1055                 1060                 1065             


Glu Thr  Gly Arg Tyr Met Gly  Lys Thr Ala Trp Asp  Lys Lys Lys 
    1070                 1075                 1080             


His Phe  Ala Thr Val Arg Lys  Val Leu Ser Tyr Pro  Gln Asn Asn 
    1085                 1090                 1095             


Ile Val  Lys Lys Thr Glu Ile  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1100                 1105                 1110             


Ser Ile  Leu Ala His Gly Asn  Ser Asp Lys Leu Ile  Pro Arg Lys 
    1115                 1120                 1125             


Thr Lys  Asp Ile Tyr Leu Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1130                 1135                 1140             


Ser Pro  Ile Val Ala Tyr Ser  Val Leu Val Val Ala  Asp Ile Lys 
    1145                 1150                 1155             


Lys Gly  Lys Ala Gln Lys Leu  Lys Thr Val Thr Glu  Leu Leu Gly 
    1160                 1165                 1170             


Ile Thr  Ile Met Glu Arg Ser  Arg Phe Glu Lys Asn  Pro Ser Ala 
    1175                 1180                 1185             


Phe Leu  Glu Ser Lys Gly Tyr  Leu Asn Ile Arg Asp  Asp Lys Leu 
    1190                 1195                 1200             


Met Ile  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1205                 1210                 1215             


Arg Arg  Leu Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1220                 1225                 1230             


Leu Ala  Leu Pro Thr Gln Phe  Met Lys Phe Leu Tyr  Leu Ala Ser 
    1235                 1240                 1245             


Arg Tyr  Asn Glu Ser Lys Gly  Lys Pro Glu Glu Ile  Glu Lys Lys 
    1250                 1255                 1260             


Gln Glu  Phe Val Asn Gln His  Val Ser Tyr Phe Asp  Asp Ile Leu 
    1265                 1270                 1275             


Gln Leu  Ile Asn Asp Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1280                 1285                 1290             


Asn Leu  Glu Lys Ile Asn Lys  Leu Tyr Gln Asp Asn  Lys Glu Asn 
    1295                 1300                 1305             


Ile Pro  Val Asp Glu Leu Ala  Asn Asn Ile Ile Asn  Leu Phe Thr 
    1310                 1315                 1320             


Phe Thr  Ser Leu Gly Ala Pro  Ala Ala Phe Lys Phe  Phe Asp Lys 
    1325                 1330                 1335             


Ile Val  Asp Arg Lys Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asn 
    1340                 1345                 1350             


Ser Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1355                 1360                 1365             


Ile Asp  Leu Gly Lys Leu Gly  Glu Asp 
    1370                 1375         


<210> 434
<211> 1370
<212> PRT
<213> Streptococcus agalactiae

<400> 434
Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Ser Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Ser Lys Gln Tyr Gln Asp Phe Leu Glu Ile 
            180                 185                 190         


Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys Tyr 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Asn  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Ala Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210> 435
<211> 1378
<212> PRT
<213> Streptococcus agalactiae


<220>
<223> Streptococcus agalactiae ATCC 13813

<400> 435
Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Tyr Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Arg Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Lys Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Arg Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His His Glu Asp Leu Lys His Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Asn Tyr Arg Glu Val Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Ser Gln Glu Ala Phe Tyr Lys Tyr Leu Leu Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Gly Ser Glu Tyr Leu Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Arg Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Leu Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Phe Leu Ala Glu Gly Phe Lys Asp Phe Gln Phe Leu Asn Arg Lys 
    530                 535                 540                 


Gln Lys Glu Thr Ile Phe Asn Ser Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile Ser Phe Leu Asn Lys Val Asp Gly Tyr Glu 
                565                 570                 575     


Gly Ile Ala Ile Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Lys Lys Ile Leu Gly Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Thr Asp Asn Glu Leu Ile Leu Glu Asp Ile Ile Gln Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Asp Ile Tyr Lys Asp 
625                 630                 635                 640 


Phe Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asn Lys 
            660                 665                 670         


Glu Asn Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ser Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile Lys Asp Ala Gly Leu Ser Phe Lys 
    690                 695                 700                 


Pro Ile Ile Asp Lys Ala Arg Thr Gly Ser His Ser Asp Asn Leu Lys 
705                 710                 715                 720 


Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val Met Gly Tyr 
            740                 745                 750         


Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr 
        755                 760                 765             


Ala Lys Gly Leu Ser Arg Ser Arg Gln Arg Leu Thr Thr Leu Arg Glu 
    770                 775                 780                 


Ser Leu Gly Asn Leu Lys Ser Asn Ile Leu Glu Glu Lys Lys Pro Lys 
785                 790                 795                 800 


Tyr Val Lys Asp Gln Val Glu Asn His His Leu Ser Asp Asp Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Asp Asp Glu 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Ile Glu Ile 
865                 870                 875                 880 


Val Lys Ala Arg Lys Met Phe Trp Lys Asn Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Leu Tyr Arg Arg  Lys Lys Leu 
    1010                 1015                 1020             


Ser Lys  Ile Val Arg Glu Asp  Lys Glu Glu Lys Tyr  Ser Glu Ala 
    1025                 1030                 1035             


Thr Arg  Lys Met Phe Phe Tyr  Ser Asn Leu Met Asn  Met Phe Lys 
    1040                 1045                 1050             


Arg Val  Val Arg Leu Ala Asp  Gly Ser Ile Val Val  Arg Pro Val 
    1055                 1060                 1065             


Ile Glu  Thr Gly Arg Tyr Met  Gly Lys Thr Ala Trp  Asp Lys Lys 
    1070                 1075                 1080             


Lys His  Phe Ala Thr Val Arg  Lys Val Leu Ser Tyr  Pro Gln Asn 
    1085                 1090                 1095             


Asn Ile  Val Lys Lys Thr Glu  Ile Gln Thr Gly Gly  Phe Ser Lys 
    1100                 1105                 1110             


Glu Ser  Ile Leu Ala His Gly  Asn Ser Asp Lys Leu  Ile Pro Arg 
    1115                 1120                 1125             


Lys Thr  Lys Asp Ile Tyr Leu  Asp Pro Lys Lys Tyr  Gly Gly Phe 
    1130                 1135                 1140             


Asp Ser  Pro Ile Val Ala Tyr  Ser Val Leu Val Val  Ala Asp Ile 
    1145                 1150                 1155             


Lys Lys  Gly Lys Ala Gln Lys  Leu Lys Thr Val Thr  Glu Leu Leu 
    1160                 1165                 1170             


Gly Ile  Thr Ile Met Glu Arg  Ser Arg Phe Glu Lys  Asn Thr Ser 
    1175                 1180                 1185             


Ala Phe  Leu Glu Ser Lys Gly  Tyr Leu Asn Ile Arg  Asp Asp Lys 
    1190                 1195                 1200             


Leu Met  Ile Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly 
    1205                 1210                 1215             


Arg Arg  Arg Leu Leu Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn 
    1220                 1225                 1230             


Glu Leu  Ala Leu Pro Thr Gln  Phe Met Lys Phe Leu  Tyr Leu Ala 
    1235                 1240                 1245             


Ser Arg  Tyr Asn Glu Ser Lys  Gly Lys Pro Glu Glu  Ile Glu Lys 
    1250                 1255                 1260             


Lys Gln  Glu Phe Val Asn Gln  His Val Ser Tyr Phe  Asp Asp Ile 
    1265                 1270                 1275             


Leu Gln  Leu Ile Asn Asp Phe  Ser Asn Arg Val Ile  Leu Ala Asp 
    1280                 1285                 1290             


Ala Asn  Leu Glu Lys Ile Asn  Lys Leu Tyr Gln Asp  Asn Lys Glu 
    1295                 1300                 1305             


Asn Ile  Pro Val Asp Glu Leu  Ala Asn Asn Ile Ile  Asn Leu Phe 
    1310                 1315                 1320             


Thr Phe  Thr Ser Leu Gly Ala  Pro Ala Ala Phe Lys  Phe Phe Asp 
    1325                 1330                 1335             


Lys Ile  Val Asp Arg Lys Arg  Tyr Thr Ser Thr Lys  Glu Val Leu 
    1340                 1345                 1350             


Asn Ser  Thr Leu Ile His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr 
    1355                 1360                 1365             


Arg Ile  Asp Leu Gly Lys Leu  Gly Glu Gly 
    1370                 1375             


<210> 436
<211> 1370
<212> PRT
<213> Streptococcus agalactiae


<220>
<223> Streptococcus agalactiae CJB111


<220>
<221> MOD_RES
<222> (117)..(117)
<223> Any amino acid

<400> 436
Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Xaa Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Ser Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Ser Lys Gln Tyr Gln Asp Phe Leu Glu Ile 
            180                 185                 190         


Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys Tyr 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Asn  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Ala Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210> 437
<211> 1370
<212> PRT
<213> Streptococcus agalactiae


<220>
<223> Streptococcus agalactiae COH1

<400> 437
Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Tyr Ser Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ser Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Asp Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asn Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Arg Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Thr Phe Glu Asn Asn His Leu Leu Ser Gln Asn Ile Asp 
        195                 200                 205             


Val Glu Gly Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Val Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Thr Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Gly Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Gly Ser Glu Tyr Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Leu Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Leu Val Asp Lys Glu Ala Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Ser Asp 
        675                 680                 685             


Gly Arg Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Pro Ile Ile Asp Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Val Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Thr Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Glu Glu Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Val Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Ile Asp Ile 
865                 870                 875                 880 


Val Lys Ala Arg Lys Ala Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Phe 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Asp Asp Lys  Leu Met Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Tyr 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Leu Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Gln  Lys Gln Glu Phe Val  Val Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Ile Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Asn Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210> 438
<211> 1370
<212> PRT
<213> Streptococcus agalactiae


<220>
<223> Streptococcus agalactiae FSL S3-026

<400> 438
Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Tyr Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Arg Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Lys Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Arg Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Gly Ser Glu Tyr Leu Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Arg Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Leu Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Phe Leu Ala Glu Gly Phe Lys Asp Phe Gln Phe Leu Asn Arg Lys 
    530                 535                 540                 


Gln Lys Glu Thr Ile Phe Asn Ser Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile Ser Phe Leu Asn Lys Val Asp Gly Tyr Glu 
                565                 570                 575     


Gly Ile Ala Ile Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Lys Lys Ile Leu Gly Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Thr Asp Asn Glu Leu Ile Leu Glu Asp Ile Val Gln Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Asp Ile Tyr Lys Asp 
625                 630                 635                 640 


Phe Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asn Lys 
            660                 665                 670         


Glu Asn Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ser Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile Lys Asp Ala Gly Leu Ser Phe Lys 
    690                 695                 700                 


Pro Ile Ile Asp Lys Ala Arg Thr Gly Ser His Ser Asp Asn Leu Lys 
705                 710                 715                 720 


Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val Met Gly Tyr 
            740                 745                 750         


Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr 
        755                 760                 765             


Ala Lys Gly Leu Ser Arg Leu Arg Gln Arg Leu Thr Thr Leu Arg Glu 
    770                 775                 780                 


Ser Leu Ala Asn Leu Lys Ser Asn Ile Leu Glu Glu Lys Lys Pro Lys 
785                 790                 795                 800 


Tyr Val Lys Asp Gln Val Glu Asn His His Leu Ser Asp Asp Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Asp Asp Glu 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Val Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Asp Asp Lys  Leu Met Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Asp Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Leu Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Gln  Lys Gln Glu Phe Val  Val Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Ile Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Asn Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Pro Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210> 439
<211> 1370
<212> PRT
<213> Streptococcus agalactiae


<220>
<223> Streptococcus agalactiae GB00112

<400> 439
Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Tyr Ser Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ser Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Asp Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Arg Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Thr Phe Glu Asn Asn His Leu Leu Ser Gln Asn Ile Asp 
        195                 200                 205             


Val Glu Gly Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Val Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Thr Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Gly Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Gly Ser Glu Tyr Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Leu Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Leu Val Asp Lys Glu Ala Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Ser Asp 
        675                 680                 685             


Gly Arg Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Pro Ile Ile Asp Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Val Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Thr Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Glu Glu Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Val Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Ile Asp Ile 
865                 870                 875                 880 


Val Lys Ala Arg Lys Ala Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Phe 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Asp Asp Lys  Leu Met Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Tyr 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Leu Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Gln  Lys Gln Glu Phe Val  Val Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Ile Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Asn Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210> 440
<211> 1370
<212> PRT
<213> Streptococcus agalactiae


<220>
<223> Streptococcus agalactiae H36B


<220>
<221> MOD_RES
<222> (9)..(9)
<223> Any amino acid

<400> 440
Met Asn Lys Pro Tyr Ser Ile Gly Xaa Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Ser Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Ser Lys Gln Tyr Gln Asp Phe Leu Glu Ile 
            180                 185                 190         


Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys Tyr 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Arg Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ala Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Ile 
865                 870                 875                 880 


Val Lys Asp Cys Lys Val Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Leu Asp Ser Lys Gly Arg Arg Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Gly 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Asp Thr Gly 
    1055                 1060                 1065             


Glu Ile  Val Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Asn  Asn Ile Val Lys Lys  Thr Glu Ile 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Gly Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Val Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Thr Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Ala Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Phe 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Gln Asp Asn Lys Glu  Asn Ile Ser Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Asn Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ile Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asn Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210> 441
<211> 1377
<212> PRT
<213> Streptococcus agalactiae

<400> 441
Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Tyr Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Arg Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Lys Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Thr Phe Glu Asn Asn His Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Val Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His His Glu Asp Leu Lys His Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Asn Tyr Arg Glu Val Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Leu Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Gly Ser Glu Tyr Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Arg Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Phe Leu Ala Glu Gly Phe Lys Asp Phe Gln Phe Leu Asn Arg Lys 
    530                 535                 540                 


Gln Lys Glu Thr Ile Phe Asn Ser Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile Ser Phe Leu Asn Lys Val Asp Gly Tyr Glu 
                565                 570                 575     


Gly Ile Ala Ile Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Lys Lys Ile Leu Gly Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Thr Asp Asn Glu Leu Ile Leu Glu Asp Ile Val Gln Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Lys Lys Cys Leu Asp Ile Tyr Lys Asp 
625                 630                 635                 640 


Phe Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asn Lys 
            660                 665                 670         


Glu Asn Gln Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ser Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Asp Leu Ser Phe Lys 
    690                 695                 700                 


Pro Ile Ile Asp Lys Ala Arg Thr Gly Ser His Ser Asp Asn Leu Lys 
705                 710                 715                 720 


Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val Met Gly Tyr 
            740                 745                 750         


Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn Gln Thr Thr 
        755                 760                 765             


Ala Lys Gly Leu Ser Arg Ser Arg Gln Arg Leu Thr Thr Leu Arg Glu 
    770                 775                 780                 


Ser Leu Ala Asn Leu Lys Ser Asn Ile Leu Glu Glu Lys Lys Pro Lys 
785                 790                 795                 800 


Tyr Val Lys Asp Gln Val Glu Asn His His Leu Ser Asp Asp Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Lys Lys Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Ile Glu Ile 
865                 870                 875                 880 


Val Lys Ala Arg Lys Met Phe Trp Lys Asn Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Met Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Ser Asp Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Glu Val Asp Asn Gly Lys Lys Ile Cys Lys Val Lys Ile Val 
945                 950                 955                 960 


Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly Phe 
                965                 970                 975     


Tyr Lys Ile Arg Glu Val Asn Asp Tyr His His Ala His Asp Ala Tyr 
            980                 985                 990         


Leu Asn Ala Val Val Ala Lys Ala  Ile Leu Thr Lys Tyr  Pro Gln Leu 
        995                 1000                 1005             


Glu Pro  Glu Phe Val Tyr Gly  Met Tyr Arg Gln Lys  Lys Leu Ser 
    1010                 1015                 1020             


Lys Ile  Val His Glu Asp Lys  Glu Glu Lys Tyr Ser  Glu Ala Thr 
    1025                 1030                 1035             


Arg Lys  Met Phe Phe Tyr Ser  Asn Leu Met Asn Met  Phe Lys Arg 
    1040                 1045                 1050             


Val Val  Arg Leu Ala Asp Gly  Ser Ile Val Val Arg  Pro Val Ile 
    1055                 1060                 1065             


Glu Thr  Gly Arg Tyr Met Arg  Lys Thr Ala Trp Asp  Lys Lys Lys 
    1070                 1075                 1080             


His Phe  Ala Thr Val Arg Lys  Val Leu Ser Tyr Pro  Gln Asn Asn 
    1085                 1090                 1095             


Ile Val  Lys Lys Thr Glu Ile  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1100                 1105                 1110             


Ser Ile  Leu Ala His Gly Asn  Ser Asp Lys Leu Ile  Pro Arg Lys 
    1115                 1120                 1125             


Thr Lys  Asp Ile Tyr Leu Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1130                 1135                 1140             


Ser Pro  Ile Val Ala Tyr Ser  Val Leu Val Val Ala  Asp Ile Lys 
    1145                 1150                 1155             


Lys Gly  Lys Ala Gln Lys Leu  Lys Thr Val Thr Glu  Leu Leu Gly 
    1160                 1165                 1170             


Ile Thr  Ile Met Glu Arg Ser  Arg Phe Glu Lys Asn  Pro Ser Ala 
    1175                 1180                 1185             


Phe Leu  Glu Ser Lys Gly Tyr  Leu Asn Ile Arg Asp  Asp Lys Leu 
    1190                 1195                 1200             


Met Ile  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1205                 1210                 1215             


Arg Arg  Leu Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1220                 1225                 1230             


Leu Ala  Leu Pro Thr Gln Phe  Met Lys Phe Leu Tyr  Leu Ala Ser 
    1235                 1240                 1245             


Arg Tyr  Asn Glu Ser Lys Gly  Lys Pro Glu Glu Ile  Glu Lys Lys 
    1250                 1255                 1260             


Gln Glu  Phe Val Asn Gln His  Val Ser Tyr Phe Asp  Asp Ile Leu 
    1265                 1270                 1275             


Gln Leu  Ile Asn Asp Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1280                 1285                 1290             


Asn Leu  Glu Lys Ile Asn Lys  Leu Tyr Gln Asp Asn  Lys Glu Asn 
    1295                 1300                 1305             


Ile Pro  Val Asp Glu Leu Ala  Asn Asn Ile Ile Asn  Leu Phe Thr 
    1310                 1315                 1320             


Phe Thr  Ser Leu Gly Ala Pro  Ala Ala Phe Lys Phe  Phe Asp Lys 
    1325                 1330                 1335             


Ile Val  Asp Arg Lys Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asn 
    1340                 1345                 1350             


Ser Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1355                 1360                 1365             


Ile Asp  Leu Gly Lys Leu Gly  Glu Asp 
    1370                 1375         


<210> 442
<211> 1370
<212> PRT
<213> Streptococcus agalactiae

<400> 442
Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Arg Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Lys Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Ser Phe Glu Asn Asn His Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Tyr Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Val 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Gln Leu Leu Asp Phe Leu Ala Lys Glu Phe Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Ile Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Arg Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Ser Asp 
        675                 680                 685             


Gly Arg Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ser Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Glu Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asp Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Val Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Ile Asp Ile 
865                 870                 875                 880 


Val Lys Ala Arg Lys Ala Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Ile Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Pro Asp Asp Lys Ala Gly Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Lys Val Asp Asp Asn Asn Lys Pro Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Glu 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Glu Thr Gly 
    1055                 1060                 1065             


Glu Ile  Ala Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Val 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Ser Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Leu Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Lys Glu Leu Ile  Gly Ile Thr Ile Met  Glu Arg Glu 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Thr Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Tyr 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Val Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Ser Asp Asn Lys Asp  Asn Thr Pro Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Lys Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ser Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asp Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210> 443
<211> 1370
<212> PRT
<213> Streptococcus agalactiae


<220>
<223> Streptococcus agalactiae STIR-CD-17

<400> 443
Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gln Glu Glu Lys Asp Tyr 
        115                 120                 125             


His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 
    130                 135                 140                 


Lys Lys Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Arg Phe Asp 
                165                 170                 175     


Val Arg Asn Thr Asp Ile Gln Lys Gln Tyr Gln Ala Phe Leu Glu Ile 
            180                 185                 190         


Phe Asp Thr Ser Phe Glu Asn Asn His Leu Leu Ser Gln Asn Val Asp 
        195                 200                 205             


Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 
    210                 215                 220                 


Arg Ile Leu Ala Gln Tyr Pro Asn Gln Lys Ser Thr Gly Ile Phe Ala 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asn Leu Glu Asp Lys Thr Pro Leu Gln Phe Ala Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Phe Ala 
        275                 280                 285             


Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Tyr Met Ile Gln Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gln Leu 
                325                 330                 335     


Lys Gln Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gln Glu Ile Phe 
            340                 345                 350         


Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Asn Gln Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gln 
    370                 375                 380                 


Glu Asp Ser Glu Tyr Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val His 
                405                 410                 415     


Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gln Ser Glu Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Asp Phe Ala 
    450                 455                 460                 


Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 
                485                 490                 495     


Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Arg Tyr Lys Asn Glu Gln Gly Glu Thr Tyr Phe Phe Asp Ser Asn Val 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 
545                 550                 555                 560 


Lys Lys Gln Leu Leu Asp Phe Leu Ala Lys Glu Phe Glu Glu Phe Arg 
                565                 570                 575     


Ile Val Asp Val Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Asp Phe 
        595                 600                 605             


Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gln Thr 
    610                 615                 620                 


Ile Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 
625                 630                 635                 640 


Tyr Lys Asp Leu Phe Thr Glu Ser Gln Leu Lys Lys Leu Tyr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Arg Glu Ser Gln Lys Thr Ile Leu Asp Tyr Leu Ile Ser Asp 
        675                 680                 685             


Gly Arg Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Ser Ile Ile Ser Lys Ala Gln Ser Gly Ser His Ser Asp 
705                 710                 715                 720 


Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Gln Gly Arg Arg Asn Ser Arg Gln Arg Tyr Lys Leu 
    770                 775                 780                 


Leu Glu Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asp Ile 
785                 790                 795                 800 


Leu Lys Glu Tyr Pro Thr Asp Asn Gln Ala Leu Gln Asn Glu Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 
            820                 825                 830         


Leu Asp Ile Asp Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Val Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Ile Asp Ile 
865                 870                 875                 880 


Val Lys Ala Arg Lys Ala Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 
                885                 890                 895     


Ile Ser Gln Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Pro Asp Asp Lys Ala Gly Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe 
    930                 935                 940                 


Asn Asn Lys Val Asp Asp Asn Asn Lys Pro Ile Arg Lys Val Lys Ile 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Phe Tyr Lys Ile Arg Glu Val Asn Asn Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Thr Lys  Tyr Pro Gln 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Lys  Thr Arg Lys Ser Ala  Thr Glu Lys Leu Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Phe Phe Lys  Thr Lys Val Thr Leu  Ala Asp Glu 
    1040                 1045                 1050             


Thr Val  Val Val Lys Asp Asp  Ile Glu Val Asn Asn  Glu Thr Gly 
    1055                 1060                 1065             


Glu Ile  Ala Trp Asp Lys Lys  Lys His Phe Ala Thr  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Val 
    1085                 1090                 1095             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Ala  His Ser Asn 
    1100                 1105                 1110             


Ser Asp  Lys Leu Ile Pro Arg  Lys Thr Lys Asp Ile  Tyr Leu Asp 
    1115                 1120                 1125             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser 
    1130                 1135                 1140             


Val Leu  Val Leu Ala Asp Ile  Lys Lys Gly Lys Ala  Gln Lys Leu 
    1145                 1150                 1155             


Lys Thr  Val Lys Glu Leu Ile  Gly Ile Thr Ile Met  Glu Arg Glu 
    1160                 1165                 1170             


Arg Phe  Glu Lys Asn Pro Ser  Ala Phe Leu Glu Ser  Lys Gly Tyr 
    1175                 1180                 1185             


Leu Asn  Ile Arg Thr Asp Lys  Leu Ile Ile Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg Leu Leu  Ala Ser Ala 
    1205                 1210                 1215             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Thr Gln Tyr 
    1220                 1225                 1230             


Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr Asn Glu  Ser Lys Gly 
    1235                 1240                 1245             


Lys Pro  Glu Glu Ile Glu Lys  Lys Gln Glu Phe Val  Asn Gln His 
    1250                 1255                 1260             


Ile Ser  Tyr Phe Asp Asp Ile  Leu Gln Leu Ile Asn  Asp Phe Ser 
    1265                 1270                 1275             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Glu Lys  Ile Asn Lys 
    1280                 1285                 1290             


Leu Tyr  Ser Asp Asn Lys Asp  Asn Thr Pro Val Asp  Glu Leu Ala 
    1295                 1300                 1305             


Lys Asn  Ile Ile Asn Leu Phe  Thr Phe Thr Ser Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Asp  Lys Ser Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Val Leu  Asp Ser Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210> 444
<211> 1125
<212> PRT
<213> Streptococcus anginosus


<220>
<223> Streptococcus anginosus 1_2_62CV

<400> 444
Met Asn Gly Leu Val Leu Gly Leu Asp Ile Gly Ile Ala Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Asn Lys Glu Thr Gly Glu Ile Ile His Ala Asn Ser 
            20                  25                  30          


Arg Ile Phe Pro Ala Ala Thr Ala Asp Ser Asn Val Glu Arg Arg Gly 
        35                  40                  45              


Phe Arg Gln Gly Arg Arg Leu Gly Arg Arg Lys Lys His Arg Ser Ala 
    50                  55                  60                  


Arg Leu Asn Asn Leu Phe Glu Glu Phe Gly Phe Ile Thr Asp Phe Ser 
65                  70                  75                  80  


Ala Ile Pro Leu Asn Leu Asn Pro Tyr Ala Leu Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Glu Glu Leu Thr Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Ile 
            100                 105                 110         


Ile Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Glu Asp Gly 
        115                 120                 125             


Glu Thr Ala Ser Asn Glu Tyr Gly Lys Ala Val Glu Glu Asn Arg Lys 
    130                 135                 140                 


Leu Leu Ala Asp Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Phe Glu 
145                 150                 155                 160 


Lys Tyr Gly Gln Val Arg Gly Asp Phe Thr Val Val Glu Asn Gly Glu 
                165                 170                 175     


Asn His Arg Leu Ile Asn Val Phe Ser Thr Ser Ala Tyr Lys Lys Glu 
            180                 185                 190         


Ala Glu Arg Ile Leu Arg Arg Gln Gln Glu Phe Asn Val Arg Ile Ser 
        195                 200                 205             


Asp Glu Phe Ile Glu Ala Tyr Leu Thr Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Phe Arg Thr Asp Gly Thr Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Asp Glu Tyr Arg Ala Ala Lys Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Pro Glu Gln Lys Arg Gln Ile 
    290                 295                 300                 


Val Glu Tyr Ala Arg Thr Ala Lys Thr Leu Gly Thr Pro Thr Leu Leu 
305                 310                 315                 320 


Lys Tyr Ile Ala Lys Leu Val Asp Gly Ser Ile Asp Asp Ile Lys Gly 
                325                 330                 335     


Tyr Arg Ile Asp Lys Ser Asp Lys Pro Glu Met His Thr Phe Asp Ala 
            340                 345                 350         


Tyr Arg Lys Met Arg Thr Leu Asp Leu Val Asn Ile Asp Ala Leu Ser 
        355                 360                 365             


Arg Glu Thr Leu Asp Asp Leu Ala His Ile Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Ser Glu Gly Ile Leu Glu Ala Leu Asn Ser Lys Met Pro Ser Thr Phe 
385                 390                 395                 400 


Thr Lys Glu Gln Ile Asp Glu Leu Ile Gln Phe Arg Lys Lys Asn Ser 
                405                 410                 415     


Ala Val Phe Gly Lys Gly Trp His Asn Phe Ser Leu Lys Leu Met Asn 
            420                 425                 430         


Glu Leu Ile Ser Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr Ile 
        435                 440                 445             


Leu Thr Arg Leu Gly Lys Gln Arg Ser Arg Glu Ile Ser Lys Arg Thr 
    450                 455                 460                 


Lys Tyr Ile Asp Glu Lys Glu Leu Thr Glu Glu Ile Tyr Asn Pro Val 
465                 470                 475                 480 


Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Ile Asn Glu Ala Thr 
                485                 490                 495     


Lys Arg Tyr Gly Ile Phe Asp Asn Ile Val Ile Glu Met Ala Arg Glu 
            500                 505                 510         


Asn Asn Glu Glu Asp Ala Lys Lys Asp Tyr Ile Lys Arg Gln Lys Ala 
        515                 520                 525             


Asn Gln Asp Glu Lys Asn Ala Ser Met Glu Lys Ala Ala Phe Gln Tyr 
    530                 535                 540                 


Asn Gly Lys Lys Glu Leu Pro Asp Ser Ile Phe His Gly His Lys Glu 
545                 550                 555                 560 


Leu Ala Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Arg Cys Leu 
                565                 570                 575     


Tyr Thr Gly Lys Asn Ile Ser Ile Arg Asp Leu Ile His Asn Pro His 
            580                 585                 590         


Gln Tyr Glu Ile Asp His Ile Leu Pro Leu Ser Leu Ser Phe Asp Asp 
        595                 600                 605             


Gly Leu Ala Asn Lys Val Leu Val Leu Ala Thr Ala Asn Gln Glu Lys 
    610                 615                 620                 


Gly Gln Arg Thr Pro Phe Gln Ala Ile Asp Ser Met Asp Asp Ala Trp 
625                 630                 635                 640 


Ser Tyr Arg Glu Phe Lys Gln Tyr Val Arg Asn Ser Lys Ser Leu Ser 
                645                 650                 655     


Asn Lys Lys Lys Asp Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys Ile 
            660                 665                 670         


Glu Val Lys Gln Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg Tyr 
        675                 680                 685             


Ser Ser Arg Val Val Leu Asn Thr Leu Gln Glu Phe Tyr Lys Thr Asn 
    690                 695                 700                 


Asp Phe Asp Thr Lys Ile Ser Val Val Arg Gly Gln Phe Thr Ser Gln 
705                 710                 715                 720 


Leu Arg Arg Lys Trp Lys Ile Glu Lys Ser Arg Asp Thr Tyr His His 
                725                 730                 735     


His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Arg Leu 
            740                 745                 750         


Trp Lys Lys Gln Asn Asn Pro Leu Ile Ser Tyr Lys Glu Gly Gln Phe 
        755                 760                 765             


Val Asp Pro Glu Thr Gly Glu Ile Leu Ser Leu Thr Asp Asp Glu Tyr 
    770                 775                 780                 


Lys Glu Leu Val Phe Arg Pro Pro Tyr Asp Tyr Phe Val Asp Thr Leu 
785                 790                 795                 800 


Lys Ser Lys Ser Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln Val Asp 
                805                 810                 815     


Ser Lys Tyr Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Gly Thr Arg 
            820                 825                 830         


Lys Ala Gln Leu Gly Lys Asp Lys Gln Glu Glu Thr Tyr Val Leu Gly 
        835                 840                 845             


Lys Ile Lys Asp Ile Tyr Ser Gln Lys Gly Tyr Glu Asp Phe Ile Lys 
    850                 855                 860                 


Arg Tyr Asn Lys Asp Glu Thr Gln Phe Leu Ile Tyr His Lys Asp Pro 
865                 870                 875                 880 


Gln Thr Phe Glu Lys Val Ile Glu Glu Ile Leu Lys Thr Tyr Pro Asp 
                885                 890                 895     


Lys Glu Leu Asn Glu Lys Gly Lys Glu Ile Pro Cys Asn Pro Phe Glu 
            900                 905                 910         


Lys Tyr Arg Gln Glu Asn Gly Pro Ile Arg Lys Tyr Ser Lys Lys Gly 
        915                 920                 925             


Lys Gly Pro Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Asn Lys Leu Gly 
    930                 935                 940                 


Asn His Ile Asp Ile Thr Pro Val Asn Ser Gln Asn Gln Val Val Leu 
945                 950                 955                 960 


Gln Ser Leu Lys Pro Trp Arg Thr Asp Val Tyr Phe Asn Pro Arg Thr 
                965                 970                 975     


Ser Lys Tyr Glu Leu Met Gly Leu Lys Tyr Ser Asp Leu Arg Phe Glu 
            980                 985                 990         


Lys Gly Ser Gly Ser Tyr Gly Ile  Ser Pro Glu Lys Tyr  Asn Lys Val 
        995                 1000                 1005             


Lys Ala  Lys Glu Gly Val Asn  Glu Asp Ser Glu Phe  Lys Phe Thr 
    1010                 1015                 1020             


Leu Tyr  Lys Asn Asp Leu Ile  Leu Ile Lys Asp Thr  Glu Thr Gly 
    1025                 1030                 1035             


Glu Gln  Gln Leu Phe Arg Tyr  Gly Ser Arg Asn Asp  Thr Ser Lys 
    1040                 1045                 1050             


His Tyr  Val Glu Leu Lys Pro  Tyr Glu Lys Ala Lys  Phe Glu Gly 
    1055                 1060                 1065             


Asn Gln  Gln Leu Met Asn Leu  Leu Gly Thr Val Ala  Lys Gly Gly 
    1070                 1075                 1080             


Gln Cys  Leu Lys Gly Ile Asn  Lys Pro Asn Leu Ser  Ile Tyr Lys 
    1085                 1090                 1095             


Val Lys  Thr Asp Val Leu Gly  Asn Lys Tyr Phe Ile  Lys Lys Glu 
    1100                 1105                 1110             


Gly Asp  Gln Pro Gln Leu Asn  Phe Lys Lys Lys Phe  
    1115                 1120                 1125 


<210> 445
<211> 1345
<212> PRT
<213> Streptococcus anginosus


<220>
<223> Streptococcus anginosus F0211

<400> 445
Met Asp Gln Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Gln Ser Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Asn Lys Val Asp Glu Asn 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Asp Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Ile Ala Ala Glu Val Lys Tyr 
        115                 120                 125             


His Asp Asp Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ile Ser Gln Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Gln Leu Lys Ala 
                165                 170                 175     


Glu Asn Thr Asn Val Gln Ala Leu Phe Lys Asp Phe Val Glu Val Tyr 
            180                 185                 190         


Asp Lys Thr Val Glu Glu Ser His Leu Ser Glu Met Thr Val Asp Ala 
        195                 200                 205             


Leu Ser Ile Leu Thr Glu Lys Val Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala His Tyr Pro Ala Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Gln Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Gly Leu Leu Gly Glu Ile Gly Asp Glu Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ala Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Asp Asp Asn Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Glu Glu His Gln Lys Asp Leu Lys Lys Leu Lys 
                325                 330                 335     


Asp Phe Ile Lys Val Asn Ala Pro Asp Gln Tyr Asn Ala Ile Phe Lys 
            340                 345                 350         


Asp Lys Asn Lys Lys Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val Lys 
        355                 360                 365             


Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Gly Ile Leu Leu Gln Ile Asn 
    370                 375                 380                 


Gly Ser Gly Asp Phe Leu Asp Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ala Ile Leu Arg Arg Gln Glu Glu His Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Gly Ser Arg Phe Ala Trp 
    450                 455                 460                 


Ala Glu Tyr Lys Ala Asp Glu Lys Ile Thr Pro Trp Asn Phe Asp Asp 
465                 470                 475                 480 


Ile Leu Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met Thr 
                485                 490                 495     


Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Asn Glu Gln Gly Glu Ala Lys Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Leu Asn Tyr Leu Asn Lys Glu Phe Glu Glu Phe Arg Ile 
                565                 570                 575     


Val Asn Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ser Ser 
            580                 585                 590         


Leu Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Ser Phe Leu 
        595                 600                 605             


Asp Asp Lys Ala Asn Glu Lys Thr Ile Glu Asp Ile Ile Gln Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Gln Arg Leu Gln Lys Tyr 
625                 630                 635                 640 


Ser Asp Ile Phe Thr Lys Ala Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Asn Lys Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Tyr Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Arg Ala Gln Ile Ile Gly Asp Val Asp Asp 
705                 710                 715                 720 


Ile Ala Asn Val Val His Asp Leu Pro Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly His Asn Pro Ala Asn Ile Ile Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Met Thr Asp Lys Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Leu Leu 
    770                 775                 780                 


Gln Asp Ser Leu Lys Asn Leu Asp Asn Pro Val Asn Ile Lys Asn Val 
785                 790                 795                 800 


Glu Asn Gln Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Ile Gln 
                805                 810                 815     


Asn Gly Lys Asp Met Tyr Thr Gly Glu Thr Leu Asp Ile Asn Asn Leu 
            820                 825                 830         


Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys Asp 
        835                 840                 845             


Asn Ser Leu Asp Asn Arg Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asp Val Pro Ser Ile Glu Val Val His Glu Met Lys Ser 
865                 870                 875                 880 


Phe Trp Ser Lys Leu Leu Ser Val Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Glu Glu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Glu Arg Phe Asn Thr Glu Phe Asp Gly 
    930                 935                 940                 


Asn Lys Arg Arg Ile Arg Asn Val Lys Ile Ile Thr Leu Lys Ser Asn 
945                 950                 955                 960 


Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Asn Ala Leu Leu Leu Lys Tyr  Pro Gln Leu Glu Pro  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Glu Tyr Pro Lys Tyr  Asn Ser Tyr Arg Ser  Arg Lys Ser 
    1010                 1015                 1020             


Ala Thr  Glu Lys Phe Leu Phe  Tyr Ser Asn Ile Leu  Arg Phe Phe 
    1025                 1030                 1035             


Lys Lys  Glu Asp Ile Gln Thr  Asn Glu Asp Gly Glu  Ile Ala Trp 
    1040                 1045                 1050             


Asn Lys  Glu Lys His Ile Lys  Ile Leu Arg Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Glu Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Asn  Ser Tyr Trp Asn Pro  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Val  Val Ala Tyr Ser Ile  Leu Val Phe 
    1115                 1120                 1125             


Ala Asp  Val Glu Lys Gly Lys  Ser Lys Lys Leu Arg  Lys Val Gln 
    1130                 1135                 1140             


Asp Met  Val Gly Ile Thr Ile  Met Glu Lys Lys Arg  Phe Glu Lys 
    1145                 1150                 1155             


His Pro  Val Asp Phe Leu Glu  Gln Arg Gly Tyr Arg  Asn Val Arg 
    1160                 1165                 1170             


Leu Glu  Lys Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu 
    1175                 1180                 1185             


Glu Asn  Lys Arg Arg Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Leu Val Ile  Pro Gln Arg Phe Thr  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ser Tyr Gln Ile Glu  Lys Asn Tyr Glu Pro  Glu His Arg 
    1220                 1225                 1230             


Glu Tyr  Val Glu Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Glu 
    1235                 1240                 1245             


Tyr Ile  Ser Val Phe Ser Arg  Lys Tyr Val Leu Ala  Asp Asn Asn 
    1250                 1255                 1260             


Leu Thr  Lys Ile Glu Met Leu  Phe Ser Lys Asn Lys  Asp Ala Glu 
    1265                 1270                 1275             


Val Ser  Ser Leu Ala Lys Ser  Phe Ile Ser Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Phe  Gly Ala Pro Ala Ala  Phe Asn Phe Phe Gly  Glu Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Val Thr Glu Cys Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Glu Asp  
    1340                 1345 


<210> 446
<211> 1386
<212> PRT
<213> Streptococcus anginosus


<220>
<223> Streptococcus anginosus SK1138

<400> 446
Met Asn Gln Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Gln Ser Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Met Gln Val Asp Glu Ser 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Asp Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Ile Ala Ala Glu Val Lys Tyr 
        115                 120                 125             


His Asp Glu Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ile Ser Gln Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Gln Leu Lys Ala 
                165                 170                 175     


Glu Asn Thr Asn Val Gln Ala Leu Phe Lys Asp Phe Val Glu Val Tyr 
            180                 185                 190         


Asp Lys Thr Val Glu Glu Ser His Leu Ser Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Leu Ser Ile Leu Thr Glu Lys Val Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala His Tyr Pro Ala Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Phe Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Gln Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Gly Leu Leu Gly Glu Val Gly Asp Glu Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ala Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Asp Asp Asn Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Glu Glu His Gln Lys Asp Leu Lys Lys Phe Glu 
                325                 330                 335     


Asp Phe Ile Lys Val Asn Ala Leu Asp Gln Tyr Asn Ala Ile Phe Lys 
            340                 345                 350         


Asp Lys Asn Lys Lys Gly Tyr Ala Gly Tyr Ile Glu Ser Gly Val Lys 
        355                 360                 365             


Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Gly Ile Leu Leu Gln Ile Asn 
    370                 375                 380                 


Gly Ser Gly Asp Phe Leu Asp Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Gly Ser Arg Phe Ala Trp 
    450                 455                 460                 


Ala Glu Tyr Lys Ala Asp Glu Lys Ile Thr Pro Trp Asn Phe Asp Asp 
465                 470                 475                 480 


Ile Leu Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met Thr 
                485                 490                 495     


Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Asn Glu Gln Gly Glu Ala Lys Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Leu Asn Tyr Leu Asn Lys Glu Phe Glu Glu Phe Arg Ile 
                565                 570                 575     


Val Asn Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ser Ser 
            580                 585                 590         


Leu Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asn Lys Ser Phe Leu 
        595                 600                 605             


Asp Asn Lys Glu Asn Ala Gln Ile Ile Glu Asp Ile Ile Gln Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Gln Arg Leu Gln Lys Tyr 
625                 630                 635                 640 


Ser Asp Ile Phe Thr Lys Ala Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Asn Lys Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Tyr Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Ile Ile Gly Asp Val Asp Asp 
705                 710                 715                 720 


Ile Ala Asn Val Val His Asp Leu Pro Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly His Asn Pro Ala Asn Ile Ile Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Asp Arg Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Leu Leu 
    770                 775                 780                 


Gln Asp Ser Leu Lys Asn Leu Asp Asn Pro Val Asn Ile Lys Asn Val 
785                 790                 795                 800 


Glu Asn Gln Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Ile Gln 
                805                 810                 815     


Asn Gly Lys Asp Met Tyr Thr Gly Glu Thr Leu Asp Ile Asn Asn Leu 
            820                 825                 830         


Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Tyr Ile Lys Asp 
        835                 840                 845             


Asp Ser Phe Asp Asn Arg Val Leu Thr Ser Ser Ser Glu Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Ile Glu Val Val Cys Ala Arg Lys Ala 
865                 870                 875                 880 


Asp Trp Met Arg Leu Arg Lys Ala Gly Leu Ile Ser Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Glu Asn Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Val Leu Asp Ala Arg Phe Asn Ala Lys His Asp Glu 
    930                 935                 940                 


Asn Lys Lys Val Ile Arg Asp Val Lys Ile Ile Thr Leu Lys Ser Asn 
945                 950                 955                 960 


Leu Val Ser Gln Phe Arg Lys Asp Phe Lys Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Ile 
            980                 985                 990         


Gly Thr Ala Leu Leu Lys Lys Tyr  Pro Lys Leu Ala Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Glu Phe Lys Lys Tyr  Asp Val Arg Lys Phe  Ile Ala Lys 
    1010                 1015                 1020             


Ser Asp  Lys Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Leu Met Asn Phe Phe  Lys Lys Glu Val Lys  Phe Ala Asp 
    1040                 1045                 1050             


Gly Thr  Val Val Glu Arg Pro  Asp Ile Glu Thr Ser  Glu Asp Gly 
    1055                 1060                 1065             


Glu Ile  Ala Trp Asn Lys Gln  Thr Asp Phe Lys Ile  Val Arg Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Val 
    1085                 1090                 1095             


Gln Thr  His Gly Leu Asp Arg  Gly Lys Pro Arg Gly  Leu Phe Asn 
    1100                 1105                 1110             


Ala Asn  Pro Ser Pro Lys Pro  Lys Pro Asp Ser Ser  Glu Asn Leu 
    1115                 1120                 1125             


Val Gly  Val Lys Arg Asn Leu  Asp Pro Lys Lys Tyr  Gly Gly Tyr 
    1130                 1135                 1140             


Ala Gly  Ile Ser Asn Ser Tyr  Ala Val Leu Val Lys  Ala Ile Ile 
    1145                 1150                 1155             


Glu Lys  Gly Val Lys Lys Lys  Glu Thr Met Val Leu  Glu Phe Gln 
    1160                 1165                 1170             


Gly Ile  Ser Ile Leu Asp Arg  Ile Thr Phe Glu Lys  Asp Lys Arg 
    1175                 1180                 1185             


Ala Phe  Leu Leu Gly Lys Gly  Tyr Lys Asp Ile Lys  Lys Ile Ile 
    1190                 1195                 1200             


Glu Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Lys Asp  Gly Ser Arg 
    1205                 1210                 1215             


Arg Met  Leu Ala Ser Ile Leu  Ser Thr Asn Asn Lys  Arg Gly Glu 
    1220                 1225                 1230             


Ile His  Lys Gly Asn Glu Leu  Phe Val Pro Gln Lys  Phe Thr Thr 
    1235                 1240                 1245             


Leu Leu  Tyr His Ala Lys Arg  Ile Asn Asn Pro Ile  Asn Lys Asp 
    1250                 1255                 1260             


His Ile  Glu Tyr Val Lys Lys  His Arg Asp Asp Phe  Lys Glu Leu 
    1265                 1270                 1275             


Leu Asn  Tyr Val Leu Glu Phe  Asn Glu Lys Tyr Val  Gly Ala Thr 
    1280                 1285                 1290             


Lys Asn  Gly Glu Arg Leu Lys  Glu Ala Val Ala Asp  Phe Asp Ser 
    1295                 1300                 1305             


Lys Ser  Asn Glu Glu Ile Cys  Thr Ser Phe Leu Gly  Ala Val Asn 
    1310                 1315                 1320             


Ser Lys  Asn Ala Gly Leu Phe  Glu Leu Thr Ser Leu  Gly Ser Ala 
    1325                 1330                 1335             


Ser Asp  Phe Glu Phe Leu Gly  Val Lys Ile Pro Arg  Tyr Arg Asp 
    1340                 1345                 1350             


Tyr Thr  Pro Ser Ser Leu Leu  Lys Asp Ser Thr Leu  Ile His Gln 
    1355                 1360                 1365             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Lys Leu 
    1370                 1375                 1380             


Gly Glu  Asp 
    1385     


<210> 447
<211> 1396
<212> PRT
<213> Streptococcus anginosus


<220>
<223> Streptococcus anginosus SK52 = DSM 20563

<400> 447
Met Thr Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asn Arg Asp Tyr Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Gly Gly Glu Thr Ala Glu Gly Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Met Gln Val Asp Glu Ser 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Glu Glu Asp Lys Gln 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Gly Thr Leu Lys Glu Glu Lys Glu Tyr 
        115                 120                 125             


His Lys Lys Phe Lys Thr Ile Tyr His Leu Arg Glu Glu Leu Ala Asn 
    130                 135                 140                 


Ser Lys Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Tyr Glu Gly Asp Leu Lys Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Ala Leu Phe Lys Asp Phe Val Glu Glu Tyr 
            180                 185                 190         


Asp Lys Thr Ile Glu Glu Ser His Leu Ser Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Leu Ser Ile Leu Thr Glu Lys Val Ser Lys Ser Ser Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala His Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Gln Ala Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Gln Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Gly Leu Leu Gly Glu Val Gly Asp Glu Tyr Ala Asp 
        275                 280                 285             


Leu Phe Val Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Asp Asp Asn Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Lys Glu His Lys Glu Glu Leu Ala Ala Phe Lys 
                325                 330                 335     


Arg Phe Ile Lys Glu Lys Leu Pro Lys Lys Tyr Glu Glu Ile Phe Lys 
            340                 345                 350         


Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Val Gly Ala Asp Lys Lys 
        355                 360                 365             


Leu Arg Lys Arg Ser Gly Lys Leu Ala Thr Glu Glu Glu Phe Tyr Lys 
    370                 375                 380                 


Tyr Val Lys Gly Ile Leu Asn Lys Val Glu Gly Ala Asp Tyr Phe Leu 
385                 390                 395                 400 


Asp Lys Ile Asp Arg Glu Asp Phe Leu Arg Lys Gln Arg Thr Phe Asp 
                405                 410                 415     


Asn Gly Ser Ile Pro His Gln Ile His Leu Gln Glu Met His Ala Ile 
            420                 425                 430         


Leu Arg Arg Gln Gly Glu His Tyr Pro Phe Leu Lys Glu Asn Gln Asp 
        435                 440                 445             


Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro 
    450                 455                 460                 


Leu Ala Arg Lys Gly Ser Arg Phe Ala Trp Ala Glu Tyr Lys Ala Asp 
465                 470                 475                 480 


Glu Lys Ile Thr Pro Trp Asn Phe Asp Asp Ile Leu Asp Lys Glu Lys 
                485                 490                 495     


Ser Ala Glu Lys Phe Ile Thr Arg Met Thr Leu Asn Asp Leu Tyr Leu 
            500                 505                 510         


Pro Glu Glu Lys Val Leu Pro Lys His Ser Pro Leu Tyr Glu Thr Phe 
        515                 520                 525             


Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Asn Glu Gln Gly 
    530                 535                 540                 


Glu Ala Lys Phe Phe Asp Thr Asn Met Lys Gln Glu Ile Phe Asp His 
545                 550                 555                 560 


Val Phe Lys Glu Asn Arg Lys Val Thr Lys Asp Lys Leu Leu Asn Tyr 
                565                 570                 575     


Leu Asn Lys Glu Phe Glu Glu Phe Arg Ile Val Asn Leu Thr Gly Leu 
            580                 585                 590         


Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
        595                 600                 605             


Leu Arg Lys Ile Leu Asp Lys Ser Phe Leu Asp Asp Lys Val Asn Glu 
    610                 615                 620                 


Lys Ile Ile Glu Asp Ile Ile Gln Thr Leu Thr Leu Phe Glu Asp Arg 
625                 630                 635                 640 


Glu Met Ile Arg Gln Arg Leu Gln Lys Tyr Ser Asp Ile Phe Thr Thr 
                645                 650                 655     


Gln Gln Leu Lys Glu Leu Glu Arg Arg His Tyr Thr Gly Trp Gly Arg 
            660                 665                 670         


Leu Ser Tyr Lys Leu Ile Asn Gly Ile Arg Asn Lys Glu Asn Lys Lys 
        675                 680                 685             


Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Tyr Ala Asn Arg Asn Phe 
    690                 695                 700                 


Met Gln Leu Ile Asn Asp Asp Ala Leu Ser Phe Lys Glu Glu Ile Ala 
705                 710                 715                 720 


Arg Ala Gln Ile Ile Gly Asp Val Asp Asp Ile Ala Asn Val Val His 
                725                 730                 735     


Asp Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Ser Val 
            740                 745                 750         


Lys Ile Val Asp Glu Leu Val Lys Val Met Gly His Asn Pro Thr Asn 
        755                 760                 765             


Ile Ile Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Asp Lys Gly Arg 
    770                 775                 780                 


Arg Asn Ser Gln Gln Arg Leu Lys Leu Leu Gln Asp Ser Leu Lys Asn 
785                 790                 795                 800 


Leu Asp Asn Pro Val Asn Ile Lys Asn Val Glu Asn Gln Gln Leu Gln 
                805                 810                 815     


Asn Asp Arg Leu Phe Leu Tyr Tyr Ile Gln Asn Gly Lys Asp Met Tyr 
            820                 825                 830         


Thr Gly Glu Thr Leu Asp Ile Asn Asn Leu Ser Gln Tyr Asp Ile Asp 
        835                 840                 845             


His Ile Ile Pro Gln Ala Phe Ile Lys Asp Asn Ser Leu Asp Asn Arg 
    850                 855                 860                 


Val Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asp Val Pro 
865                 870                 875                 880 


Ser Ile Glu Val Val His Glu Met Lys Ser Phe Trp Ser Lys Leu Leu 
                885                 890                 895     


Ser Val Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala 
            900                 905                 910         


Glu Arg Gly Gly Leu Thr Glu Asn Asp Lys Ala Gly Phe Ile Lys Arg 
        915                 920                 925             


Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Val Leu 
    930                 935                 940                 


Asp Ala Arg Phe Asn Ala Lys His Asp Glu Asn Lys Lys Val Ile Arg 
945                 950                 955                 960 


Asp Val Lys Ile Ile Thr Leu Lys Ser Asn Leu Val Ser Gln Phe Arg 
                965                 970                 975     


Lys Asp Phe Lys Phe Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His 
            980                 985                 990         


Ala His Asp Ala Tyr Leu Asn Ala  Val Ile Gly Thr Ala  Leu Leu Lys 
        995                 1000                 1005             


Lys Tyr  Pro Lys Leu Ala Ser  Glu Phe Val Tyr Gly  Glu Phe Lys 
    1010                 1015                 1020             


Lys Tyr  Asp Val Arg Lys Phe  Ile Ala Lys Ser Asp  Lys Glu Ile 
    1025                 1030                 1035             


Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr Ser Asn  Leu Met Asn 
    1040                 1045                 1050             


Phe Phe  Lys Lys Glu Val Lys  Phe Ala Asp Gly Thr  Val Val Glu 
    1055                 1060                 1065             


Arg Pro  Asp Ile Glu Thr Ser  Glu Asp Gly Glu Ile  Ala Trp Asn 
    1070                 1075                 1080             


Lys Gln  Thr Asp Phe Lys Ile  Val Arg Lys Val Leu  Ser Tyr Pro 
    1085                 1090                 1095             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  His Gly Leu 
    1100                 1105                 1110             


Asp Arg  Gly Lys Pro Arg Gly  Leu Phe Asn Ala Asn  Pro Ser Pro 
    1115                 1120                 1125             


Lys Pro  Lys Pro Asp Ser Ser  Glu Asn Leu Val Gly  Ile Lys Arg 
    1130                 1135                 1140             


Asn Leu  Asp Pro Lys Lys Tyr  Gly Gly Tyr Ala Gly  Ile Ser Asn 
    1145                 1150                 1155             


Ser Tyr  Ala Val Leu Val Lys  Ala Ile Ile Glu Lys  Gly Val Lys 
    1160                 1165                 1170             


Lys Lys  Glu Thr Met Val Leu  Glu Phe Gln Gly Ile  Ser Ile Leu 
    1175                 1180                 1185             


Asp Arg  Ile Thr Phe Glu Lys  Asp Lys Arg Ala Phe  Leu Leu Gly 
    1190                 1195                 1200             


Lys Gly  Tyr Lys Asp Ile Lys  Lys Ile Ile Glu Leu  Pro Lys Tyr 
    1205                 1210                 1215             


Ser Leu  Phe Glu Leu Lys Asp  Gly Ser Arg Arg Met  Leu Ala Ser 
    1220                 1225                 1230             


Ile Leu  Ser Thr Asn Asn Lys  Arg Gly Glu Ile His  Lys Gly Asn 
    1235                 1240                 1245             


Glu Leu  Phe Val Pro Gln Lys  Phe Thr Thr Leu Leu  Tyr His Ala 
    1250                 1255                 1260             


Lys Arg  Ile Asn Asn Pro Ile  Asn Lys Asp His Ile  Glu Tyr Val 
    1265                 1270                 1275             


Lys Lys  His Arg Asp Asp Phe  Lys Glu Leu Leu Asn  Tyr Val Leu 
    1280                 1285                 1290             


Glu Phe  Asn Glu Lys Tyr Val  Gly Ala Thr Lys Asn  Gly Glu Arg 
    1295                 1300                 1305             


Leu Lys  Glu Ala Val Ala Asp  Phe Asp Ser Lys Ser  Asn Glu Glu 
    1310                 1315                 1320             


Ile Cys  Thr Ser Phe Leu Gly  Ala Val Asn Ser Lys  Asn Ala Gly 
    1325                 1330                 1335             


Leu Phe  Glu Leu Thr Ser Leu  Gly Ser Ala Ser Asp  Phe Glu Phe 
    1340                 1345                 1350             


Leu Gly  Val Lys Ile Pro Arg  Tyr Arg Asp Tyr Thr  Pro Ser Ser 
    1355                 1360                 1365             


Leu Leu  Lys Asp Ser Ile Leu  Ile His Gln Ser Ile  Thr Gly Leu 
    1370                 1375                 1380             


Tyr Glu  Thr Arg Ile Asp Leu  Ser Lys Leu Gly Glu  Asp 
    1385                 1390                 1395     


<210> 448
<211> 1373
<212> PRT
<213> Streptococcus bovis


<220>
<223> Streptococcus bovis ATCC 700338

<400> 448
Met Thr Lys Lys Asn Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys Lys Tyr Ile Lys Lys Asn Leu 
        35                  40                  45              


Leu Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Thr Lys Val Asp Glu 
                85                  90                  95      


Ser Phe Phe Gln Arg Leu Asp Glu Ser Phe Leu Arg Trp Asp Asp Asp 
            100                 105                 110         


Asn Lys Lys Leu Gly Arg Tyr Pro Ile Phe Gly Asn Lys Ala Asp Val 
        115                 120                 125             


Val Lys Tyr His Gln Glu Phe Pro Thr Ile Tyr His Leu Arg Lys His 
    130                 135                 140                 


Leu Ala Asp Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala 
145                 150                 155                 160 


Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Glu 
                165                 170                 175     


Leu Asn Ala Glu Asn Thr Asp Val Gln Lys Ile Phe Ala Asp Phe Val 
            180                 185                 190         


Gly Val Tyr Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr 
        195                 200                 205             


Val Asp Ala Ala Ser Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg 
    210                 215                 220                 


Leu Glu Asn Leu Ile Lys Tyr Tyr Pro Thr Glu Lys Lys Asn Thr Leu 
225                 230                 235                 240 


Phe Gly Asn Leu Ile Ala Leu Ala Leu Gly Leu Gln Pro Asn Phe Lys 
                245                 250                 255     


Met Asn Phe Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp 
            260                 265                 270         


Ser Tyr Glu Glu Asp Leu Gly Glu Leu Leu Gly Lys Ile Gly Asp Asp 
        275                 280                 285             


Tyr Ala Asp Leu Phe Thr Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu 
    290                 295                 300                 


Leu Ser Gly Ile Leu Ile Val Asp Asp Asn Ser Thr Lys Ala Pro Leu 
305                 310                 315                 320 


Ser Ala Ser Met Ile Lys Arg Tyr Val Glu His Gln Glu Asp Leu Glu 
                325                 330                 335     


Lys Leu Lys Glu Phe Ile Lys Ala Asn Lys Ser Glu Leu Tyr His Asp 
            340                 345                 350         


Ile Phe Lys Asp Lys Asn Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn 
        355                 360                 365             


Gly Val Lys Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Asn Thr Leu Ser 
    370                 375                 380                 


Lys Ile Ala Gly Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp 
385                 390                 395                 400 


Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln 
                405                 410                 415     


Ile His Leu Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Asp Tyr 
            420                 425                 430         


Tyr Pro Phe Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr 
        435                 440                 445             


Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Asp Ser Arg 
    450                 455                 460                 


Phe Ser Trp Ala Glu Tyr His Ser Asp Glu Lys Ile Thr Pro Trp Asn 
465                 470                 475                 480 


Phe Asp Lys Val Ile Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr 
                485                 490                 495     


Arg Met Thr Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro 
            500                 505                 510         


Lys His Ser His Val Tyr Glu Thr Tyr Ala Val Tyr Asn Glu Leu Thr 
        515                 520                 525             


Lys Ile Lys Tyr Val Asn Glu Gln Gly Lys Asp Ser Phe Phe Asp Ser 
    530                 535                 540                 


Asn Met Lys Gln Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys 
545                 550                 555                 560 


Val Thr Lys Glu Lys Leu Leu Asn Tyr Leu Asn Lys Glu Phe Pro Glu 
                565                 570                 575     


Tyr Arg Ile Lys Asp Leu Ile Gly Leu Asp Lys Glu Asn Lys Ser Phe 
            580                 585                 590         


Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys 
        595                 600                 605             


Ala Phe Leu Asp Asp Lys Val Asn Glu Glu Val Ile Glu Asp Ile Ile 
    610                 615                 620                 


Lys Thr Leu Thr Leu Phe Glu Asp Lys Asp Met Ile His Glu Arg Leu 
625                 630                 635                 640 


Gln Lys Tyr Ser Asp Ile Phe Thr Ala Asp Gln Leu Lys Lys Leu Glu 
                645                 650                 655     


Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn 
            660                 665                 670         


Gly Ile Arg Asn Lys Glu Asn Asn Lys Thr Ile Leu Asp Tyr Leu Ile 
        675                 680                 685             


Asp Asp Gly Ser Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp 
    690                 695                 700                 


Thr Leu Pro Phe Lys Gln Ile Ile Gln Lys Ser Gln Val Val Gly Asp 
705                 710                 715                 720 


Val Asp Asp Ile Glu Ala Val Val His Asp Leu Pro Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu Val 
            740                 745                 750         


Lys Val Met Gly Asp Asn Pro Asp Asn Ile Val Ile Glu Met Ala Arg 
        755                 760                 765             


Glu Asn Gln Thr Thr Asn Arg Gly Arg Ser Gln Ser Gln Gln Arg Leu 
    770                 775                 780                 


Lys Lys Leu Gln Asn Ser Leu Lys Glu Leu Gly Ser Asn Ile Leu Asn 
785                 790                 795                 800 


Glu Glu Lys Pro Ser Tyr Ile Glu Asp Lys Val Glu Asn Ser His Leu 
                805                 810                 815     


Gln Asn Asp Gln Leu Phe Leu Tyr Tyr Ile Gln Asn Gly Lys Asp Met 
            820                 825                 830         


Tyr Thr Gly Asp Glu Leu Asp Ile Asp His Leu Ser Asp Tyr Asp Ile 
        835                 840                 845             


Asp His Ile Ile Pro Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn 
    850                 855                 860                 


Arg Val Leu Thr Ser Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val 
865                 870                 875                 880 


Pro Ser Leu Asp Ile Val Arg Ala Arg Lys Ala Glu Trp Val Arg Leu 
                885                 890                 895     


Tyr Lys Ser Gly Leu Ile Ser Lys Arg Lys Phe Asp Asn Leu Thr Lys 
            900                 905                 910         


Ala Glu Arg Gly Gly Leu Thr Glu Ala Asp Lys Ala Gly Phe Ile Lys 
        915                 920                 925             


Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile 
    930                 935                 940                 


Leu Asp Ala Arg Phe Asn Thr Glu Ser Asp Glu Asn Asp Lys Val Ile 
945                 950                 955                 960 


Arg Asp Val Lys Val Ile Thr Leu Lys Ser Asn Leu Val Ser Gln Phe 
                965                 970                 975     


Arg Lys Asp Phe Glu Phe Tyr Lys Val Arg Glu Ile Asn Asp Tyr His 
            980                 985                 990         


His Ala His Asp Ala Tyr Leu Asn  Ala Val Val Gly Thr  Ala Leu Leu 
        995                 1000                 1005             


Lys Lys  Tyr Pro Lys Leu Ala  Ser Glu Phe Val Tyr  Gly Glu Tyr 
    1010                 1015                 1020             


Lys Lys  Tyr Asp Ile Arg Lys  Phe Ile Thr Asn Ser  Ser Asp Lys 
    1025                 1030                 1035             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Leu Met  Asn Phe Phe 
    1040                 1045                 1050             


Lys Arg  Val Ile Arg Tyr Ser  Asn Gly Lys Val Ile  Val Arg Pro 
    1055                 1060                 1065             


Val Val  Glu Tyr Ser Lys Asp  Thr Glu Asp Ile Ala  Trp Asp Lys 
    1070                 1075                 1080             


Lys Ser  Asn Phe Arg Thr Ile  Cys Lys Val Leu Ser  Tyr Pro Gln 
    1085                 1090                 1095             


Val Asn  Ile Val Lys Lys Val  Glu Thr Gln Thr Gly  Gly Phe Ser 
    1100                 1105                 1110             


Lys Glu  Ser Ile Leu Pro Lys  Gly Asp Ser Asp Lys  Leu Ile Pro 
    1115                 1120                 1125             


Arg Lys  Thr Lys Lys Ala Tyr  Trp Asp Thr Lys Lys  Tyr Gly Gly 
    1130                 1135                 1140             


Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val Phe Val  Val Ala Asp 
    1145                 1150                 1155             


Val Glu  Lys Gly Lys Ala Lys  Lys Leu Lys Thr Val  Lys Glu Leu 
    1160                 1165                 1170             


Val Gly  Ile Ser Ile Met Glu  Arg Ser Phe Phe Glu  Glu Asn Pro 
    1175                 1180                 1185             


Val Glu  Phe Leu Glu Asn Lys  Gly Tyr His Asn Ile  Arg Glu Asp 
    1190                 1195                 1200             


Lys Leu  Ile Lys Leu Pro Lys  Tyr Ser Leu Phe Glu  Phe Glu Gly 
    1205                 1210                 1215             


Gly Lys  Arg Arg Leu Leu Ala  Ser Ala Ser Glu Leu  Gln Lys Gly 
    1220                 1225                 1230             


Asn Glu  Met Val Ile Pro Gly  His Leu Val Lys Leu  Leu Tyr His 
    1235                 1240                 1245             


Ala Gln  Arg Ile Asn Ser Phe  Asn Ser Thr Lys Tyr  Leu Asp Tyr 
    1250                 1255                 1260             


Val Ser  Ala His Lys Lys Glu  Phe Glu Lys Val Leu  Ser Cys Val 
    1265                 1270                 1275             


Glu Asp  Phe Ala Asn Leu Tyr  Val Asp Val Glu Lys  Asn Leu Ser 
    1280                 1285                 1290             


Lys Ile  Arg Ala Val Ala Asp  Ser Met Asp Asn Phe  Ser Ile Glu 
    1295                 1300                 1305             


Glu Ile  Ser Asn Ser Phe Ile  Asn Leu Leu Thr Leu  Thr Ala Leu 
    1310                 1315                 1320             


Gly Ala  Pro Ala Asp Phe Asn  Phe Leu Gly Glu Lys  Ile Pro Arg 
    1325                 1330                 1335             


Lys Arg  Tyr Thr Ser Thr Lys  Glu Cys Leu Asn Ala  Thr Leu Ile 
    1340                 1345                 1350             


His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser 
    1355                 1360                 1365             


Lys Ile  Gly Glu Glu 
    1370             


<210> 449
<211> 1375
<212> PRT
<213> Streptococcus canis


<220>
<223> Streptococcus canis FSL Z3-227

<400> 449
Met Glu Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asn Arg Lys Ser Ile Lys Lys Asn Leu Met 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Asn Glu Met Ala Lys Leu Asp Asp Ser 
                85                  90                  95      


Phe Phe Gln Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


Asn Glu Arg His Pro Ile Phe Gly Asn Leu Ala Asp Glu Val Ala Tyr 
        115                 120                 125             


His Arg Asn Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Pro Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Leu Asn Ala 
                165                 170                 175     


Glu Asn Ser Asp Val Ala Lys Leu Phe Tyr Gln Leu Ile Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Ser Pro Leu Asp Glu Ile Glu Val Asp Ala 
        195                 200                 205             


Lys Gly Ile Leu Ser Ala Arg Leu Ser Lys Ser Lys Arg Leu Glu Lys 
    210                 215                 220                 


Leu Ile Ala Val Phe Pro Asn Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Ile Ile Ala Leu Ala Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Thr Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Glu Leu Leu Gly Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ser Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Ser Asn Ser Glu Val Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Asp Glu His His Gln Asp Leu Ala Leu Leu Lys 
                325                 330                 335     


Thr Leu Val Arg Gln Gln Phe Pro Glu Lys Tyr Ala Glu Ile Phe Lys 
            340                 345                 350         


Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Val Gly Ile Gly Ile Lys 
        355                 360                 365             


His Arg Lys Arg Thr Thr Lys Leu Ala Thr Gln Glu Glu Phe Tyr Lys 
    370                 375                 380                 


Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Ala Glu Glu Leu Leu 
385                 390                 395                 400 


Ala Lys Leu Asn Arg Asp Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp 
                405                 410                 415     


Asn Gly Ser Ile Pro His Gln Ile His Leu Lys Glu Leu His Ala Ile 
            420                 425                 430         


Leu Arg Arg Gln Glu Glu Phe Tyr Pro Phe Leu Lys Glu Asn Arg Glu 
        435                 440                 445             


Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro 
    450                 455                 460                 


Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Leu Thr Arg Lys Ser Glu 
465                 470                 475                 480 


Glu Ala Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala 
                485                 490                 495     


Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Glu Gln Leu 
            500                 505                 510         


Pro Asn Lys Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe 
        515                 520                 525             


Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Arg Met 
    530                 535                 540                 


Arg Lys Pro Glu Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp 
545                 550                 555                 560 


Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu 
                565                 570                 575     


Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ile Gly 
            580                 585                 590         


Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu 
        595                 600                 605             


Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp 
    610                 615                 620                 


Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu 
625                 630                 635                 640 


Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys 
                645                 650                 655     


Val Met Lys Gln Leu Lys Arg Arg His Tyr Thr Gly Trp Gly Arg Leu 
            660                 665                 670         


Ser Arg Lys Met Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr 
        675                 680                 685             


Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ser Asn Arg Asn Phe Met 
    690                 695                 700                 


Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu Glu Ile Glu Lys 
705                 710                 715                 720 


Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu Gln Ile Ala Asp 
                725                 730                 735     


Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys 
            740                 745                 750         


Ile Val Asp Glu Leu Val Lys Val Met Gly His Lys Pro Glu Asn Ile 
        755                 760                 765             


Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Thr Lys Gly Leu Gln 
    770                 775                 780                 


Gln Ser Arg Glu Arg Lys Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu 
785                 790                 795                 800 


Glu Ser Gln Ile Leu Lys Glu Asn Pro Val Glu Asn Thr Gln Leu Gln 
                805                 810                 815     


Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr 
            820                 825                 830         


Val Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp 
        835                 840                 845             


His Ile Val Pro Gln Ser Phe Ile Lys Asp Asp Ser Ile Asp Asn Lys 
    850                 855                 860                 


Val Leu Thr Arg Ser Val Glu Asn Arg Gly Lys Ser Asp Asn Val Pro 
865                 870                 875                 880 


Ser Glu Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu 
                885                 890                 895     


Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala 
            900                 905                 910         


Glu Arg Gly Gly Leu Ser Glu Ala Asp Lys Ala Gly Phe Ile Lys Arg 
        915                 920                 925             


Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu 
    930                 935                 940                 


Asp Ser Arg Met Asn Thr Lys Arg Asp Lys Asn Asp Lys Pro Ile Arg 
945                 950                 955                 960 


Glu Val Lys Val Ile Thr Leu Lys Ser Lys Leu Val Ser Asp Phe Arg 
                965                 970                 975     


Lys Asp Phe Gln Leu Tyr Lys Val Arg Asp Ile Asn Asn Tyr His His 
            980                 985                 990         


Ala His Asp Ala Tyr Leu Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys 
        995                 1000                 1005             


Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys 
    1010                 1015                 1020             


Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile 
    1025                 1030                 1035             


Gly Lys  Ala Thr Ala Lys Arg  Phe Phe Tyr Ser Asn  Ile Met Asn 
    1040                 1045                 1050             


Phe Phe  Lys Thr Glu Val Lys  Leu Ala Asn Gly Glu  Ile Arg Lys 
    1055                 1060                 1065             


Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr Gly Glu  Val Val Trp 
    1070                 1075                 1080             


Asn Lys  Glu Lys Asp Phe Ala  Thr Val Arg Lys Val  Leu Ala Met 
    1085                 1090                 1095             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly 
    1100                 1105                 1110             


Phe Ser  Lys Glu Ser Ile Leu  Ser Lys Arg Glu Ser  Ala Lys Leu 
    1115                 1120                 1125             


Ile Pro  Arg Lys Lys Gly Trp  Asp Thr Arg Lys Tyr  Gly Gly Phe 
    1130                 1135                 1140             


Gly Ser  Pro Thr Val Ala Tyr  Ser Ile Leu Val Val  Ala Lys Val 
    1145                 1150                 1155             


Glu Lys  Gly Lys Ala Lys Lys  Leu Lys Ser Val Lys  Val Leu Val 
    1160                 1165                 1170             


Gly Ile  Thr Ile Met Glu Lys  Gly Ser Tyr Glu Lys  Asp Pro Ile 
    1175                 1180                 1185             


Gly Phe  Leu Glu Ala Lys Gly  Tyr Lys Asp Ile Lys  Lys Glu Leu 
    1190                 1195                 1200             


Ile Phe  Lys Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly 
    1205                 1210                 1215             


Arg Arg  Arg Met Leu Ala Ser  Ala Thr Glu Leu Gln  Lys Ala Asn 
    1220                 1225                 1230             


Glu Leu  Val Leu Pro Gln His  Leu Val Arg Leu Leu  Tyr Tyr Thr 
    1235                 1240                 1245             


Gln Asn  Ile Ser Ala Thr Thr  Gly Ser Asn Asn Leu  Gly Tyr Ile 
    1250                 1255                 1260             


Glu Gln  His Arg Glu Glu Phe  Lys Glu Ile Phe Glu  Lys Ile Ile 
    1265                 1270                 1275             


Asp Phe  Ser Glu Lys Tyr Ile  Leu Lys Asn Lys Val  Asn Ser Asn 
    1280                 1285                 1290             


Leu Lys  Ser Ser Phe Asp Glu  Gln Phe Ala Val Ser  Asp Ser Ile 
    1295                 1300                 1305             


Leu Leu  Ser Asn Ser Phe Val  Ser Leu Leu Lys Tyr  Thr Ser Phe 
    1310                 1315                 1320             


Gly Ala  Ser Gly Gly Phe Thr  Phe Leu Asp Leu Asp  Val Lys Gln 
    1325                 1330                 1335             


Gly Arg  Leu Arg Tyr Gln Thr  Val Thr Glu Val Leu  Asp Ala Thr 
    1340                 1345                 1350             


Leu Ile  Tyr Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Thr Asp 
    1355                 1360                 1365             


Leu Ser  Gln Leu Gly Gly Asp  
    1370                 1375 


<210> 450
<211> 1345
<212> PRT
<213> Streptococcus constellatus


<220>
<223> Streptococcus constellatus subsp. constellatus SK53

<400> 450
Met Gly Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Gln Ser Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Thr Gly Glu Met Asn Lys Val Asp Glu Asn 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Asp Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu His His Pro Ile Phe Gly Asn Ile Ala Ala Glu Val Lys Tyr 
        115                 120                 125             


His Asp Asp Phe Pro Thr Ile Tyr His Leu Arg Arg His Leu Ala Asp 
    130                 135                 140                 


Thr Ser Lys Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Tyr Glu Gly Asp Leu Lys Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Ala Leu Phe Lys Asp Phe Val Glu Glu Tyr 
            180                 185                 190         


Asp Lys Thr Ile Glu Glu Ser His Leu Ser Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Leu Ser Ile Leu Thr Glu Lys Val Ser Lys Ser Ser Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala His Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Asp Leu His Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Gln Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Gly Phe Leu Gly Glu Val Gly Asp Glu Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ala Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Asp Asp Asn Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Glu Glu His Gln Lys Asp Leu Lys Lys Leu Lys 
                325                 330                 335     


Asp Phe Ile Lys Val Asn Ala Pro Asp Gln Tyr Asn Ala Ile Phe Lys 
            340                 345                 350         


Asp Lys Asn Lys Lys Gly Tyr Ala Ser Tyr Ile Glu Ser Gly Val Lys 
        355                 360                 365             


Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Gly Ile Leu Leu Lys Ile Asn 
    370                 375                 380                 


Gly Ser Gly Asp Phe Leu Asp Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Gly Ser Arg Phe Ala Trp 
    450                 455                 460                 


Ala Glu Tyr Lys Ala Asp Glu Lys Ile Thr Pro Trp Asn Phe Asp Asp 
465                 470                 475                 480 


Ile Leu Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met Thr 
                485                 490                 495     


Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Pro Leu Tyr Glu Ala Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Asn Glu Gln Gly Glu Ala Lys Phe Phe Asp Thr Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Leu Asn Tyr Leu Asn Lys Glu Phe Glu Glu Phe Arg Ile 
                565                 570                 575     


Val Asn Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ser Ser 
            580                 585                 590         


Leu Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Ser Phe Leu 
        595                 600                 605             


Asp Asp Lys Ala Asn Glu Lys Thr Ile Glu Asp Ile Ile Gln Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Gln Arg Leu Gln Lys Tyr 
625                 630                 635                 640 


Ser Asp Ile Phe Thr Lys Ala Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Asn Lys Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Tyr Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Arg Ala Gln Ile Ile Asp Asp Val Asp Asp 
705                 710                 715                 720 


Ile Ala Asn Val Val His Asp Leu Pro Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly His Asn Pro Ala Asn Ile Ile Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Asp Lys Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Leu Leu 
    770                 775                 780                 


Gln Asp Ser Leu Lys Asn Leu Asp Asn Pro Val Asn Ile Lys Asn Val 
785                 790                 795                 800 


Glu Asn Gln Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Ile Gln 
                805                 810                 815     


Asn Gly Lys Asp Met Tyr Thr Gly Glu Thr Leu Asp Ile Asn Asn Leu 
            820                 825                 830         


Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys Asp 
        835                 840                 845             


Asn Ser Leu Asp Asn Arg Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asp Val Pro Ser Ile Glu Val Val His Glu Met Lys Ser 
865                 870                 875                 880 


Phe Trp Ser Lys Leu Leu Ser Val Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Glu Glu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Glu Arg Phe Asn Thr Glu Phe Asp Gly 
    930                 935                 940                 


Asn Lys Arg Arg Ile Arg Asn Val Lys Ile Ile Thr Leu Lys Ser Asn 
945                 950                 955                 960 


Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Asn Ala Leu Leu Leu Lys Tyr  Pro Gln Leu Glu Pro  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Glu Tyr Pro Lys Tyr  Asn Ser Tyr Arg Ser  Arg Lys Ser 
    1010                 1015                 1020             


Ala Thr  Glu Lys Phe Leu Phe  Tyr Ser Asn Ile Leu  Arg Phe Phe 
    1025                 1030                 1035             


Lys Lys  Glu Asp Ile Gln Thr  Asn Glu Asp Gly Glu  Ile Ala Trp 
    1040                 1045                 1050             


Asn Lys  Glu Lys His Ile Lys  Ile Leu Arg Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Glu Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Asn  Ser Tyr Trp Asp Pro  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Val  Val Ala Tyr Ser Ile  Leu Val Phe 
    1115                 1120                 1125             


Ala Asp  Val Glu Lys Gly Lys  Ser Lys Lys Leu Arg  Lys Val Gln 
    1130                 1135                 1140             


Asp Met  Val Gly Ile Thr Ile  Met Glu Lys Lys Arg  Phe Glu Lys 
    1145                 1150                 1155             


Asn Pro  Val Asp Phe Leu Glu  Gln Arg Gly Tyr Arg  Asn Val Arg 
    1160                 1165                 1170             


Leu Glu  Lys Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu 
    1175                 1180                 1185             


Glu Asn  Lys Arg Arg Arg Leu  Leu Ala Ser Ala Lys  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Leu Val Ile  Pro Gln Arg Phe Thr  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ser Tyr Arg Ile Glu  Lys Asp Tyr Glu Pro  Glu His Arg 
    1220                 1225                 1230             


Glu Tyr  Val Glu Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Glu 
    1235                 1240                 1245             


Tyr Ile  Ser Val Phe Ser Arg  Lys Tyr Val Leu Ala  Asp Asn Asn 
    1250                 1255                 1260             


Leu Thr  Lys Ile Glu Met Leu  Phe Ser Lys Asn Lys  Asp Ala Glu 
    1265                 1270                 1275             


Val Ser  Ser Leu Ala Lys Ser  Phe Ile Ser Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Phe  Gly Ala Pro Ala Ala  Phe Asn Phe Phe Gly  Glu Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Val Thr Glu Cys Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Glu Asp  
    1340                 1345 


<210> 451
<211> 1371
<212> PRT
<213> Streptococcus dysgalactiae

<400> 451
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Ser Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Met Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Arg Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Glu Phe Leu Ser Gly Lys Gln 
    530                 535                 540                 


Lys Glu Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Lys Glu Met Ile Glu Glu Arg Leu Lys Lys Tyr Ala 
625                 630                 635                 640 


Asn Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Ala Ile Gln Lys Ala Gln Val Ser Gly Gln Gly His Ser Leu 
705                 710                 715                 720 


His Glu Gln Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Arg  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Glu Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Ala Leu Thr  Asn Glu Ser Ile Tyr  Ala Arg Gly 
    1100                 1105                 1110             


Ser Phe  Asp Lys Leu Ile Ser  Arg Lys His Arg Phe  Glu Ser Ser 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Gly Ser  Pro Thr Val Thr Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Ser Lys Val  Gln Asp Gly Lys Val  Lys Lys Ile 
    1145                 1150                 1155             


Lys Thr  Gly Lys Glu Leu Ile  Gly Ile Thr Leu Leu  Asp Lys Leu 
    1160                 1165                 1170             


Val Phe  Glu Lys Asn Pro Leu  Lys Phe Ile Glu Asp  Lys Gly Tyr 
    1175                 1180                 1185             


Gly Asn  Val Gln Ile Asp Lys  Cys Ile Lys Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Phe Glu Asn Gly  Thr Arg Arg Met Leu  Ala Ser Val 
    1205                 1210                 1215             


Met Ala  Asn Asn Asn Ser Arg  Gly Asp Leu Gln Lys  Ala Asn Glu 
    1220                 1225                 1230             


Met Phe  Leu Pro Ala Lys Leu  Val Thr Leu Leu Tyr  His Ala His 
    1235                 1240                 1245             


Lys Ile  Glu Ser Ser Lys Glu  Leu Glu His Glu Ala  Tyr Ile Leu 
    1250                 1255                 1260             


Asp His  Tyr Asn Asp Leu Tyr  Gln Leu Leu Ser Tyr  Ile Glu Arg 
    1265                 1270                 1275             


Phe Ala  Ser Leu Tyr Val Asp  Val Glu Lys Asn Ile  Ser Lys Val 
    1280                 1285                 1290             


Lys Glu  Leu Phe Ser Asn Ile  Glu Ser Tyr Ser Ile  Ser Glu Ile 
    1295                 1300                 1305             


Cys Ser  Ser Val Ile Asn Leu  Leu Thr Leu Thr Ala  Ser Gly Ala 
    1310                 1315                 1320             


Pro Ala  Asp Phe Lys Phe Leu  Gly Thr Thr Ile Pro  Arg Lys Arg 
    1325                 1330                 1335             


Tyr Gly  Ser Pro Gln Ser Ile  Leu Ser Ser Thr Leu  Ile His Gln 
    1340                 1345                 1350             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu 
    1355                 1360                 1365             


Gly Gly  Asp 
    1370     


<210> 452
<211> 1371
<212> PRT
<213> Streptococcus dysgalactiae

<400> 452
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Ser Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Lys Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Lys Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asn Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Glu Phe Leu Ser Gly Lys Gln 
    530                 535                 540                 


Lys Glu Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Lys Glu Met Ile Glu Glu Arg Leu Lys Lys Tyr Ala 
625                 630                 635                 640 


Asn Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Ala Ile Gln Lys Ala Gln Val Ser Gly Gln Gly His Ser Leu 
705                 710                 715                 720 


His Glu Gln Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Arg  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Glu Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Ala Leu Thr  Asn Glu Ser Ile Tyr  Ala Arg Gly 
    1100                 1105                 1110             


Ser Phe  Asp Lys Leu Ile Ser  Arg Lys His Arg Phe  Glu Ser Ser 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Gly Ser  Pro Thr Val Thr Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Ser Lys Val  Gln Asp Gly Lys Val  Lys Lys Ile 
    1145                 1150                 1155             


Lys Thr  Gly Lys Glu Leu Ile  Gly Ile Thr Leu Leu  Asp Lys Leu 
    1160                 1165                 1170             


Val Phe  Glu Lys Asn Pro Leu  Lys Phe Ile Glu Asp  Lys Gly Tyr 
    1175                 1180                 1185             


Gly Asn  Val Gln Ile Asp Lys  Cys Ile Lys Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Phe Glu Asn Gly  Thr Arg Arg Met Leu  Ala Ser Val 
    1205                 1210                 1215             


Met Ala  Asn Asn Asn Ser Arg  Gly Asp Leu Gln Lys  Ala Asn Glu 
    1220                 1225                 1230             


Met Phe  Leu Pro Ala Lys Leu  Val Thr Leu Leu Tyr  His Ala His 
    1235                 1240                 1245             


Lys Ile  Glu Ser Ser Lys Glu  Leu Glu His Glu Ala  Tyr Ile Leu 
    1250                 1255                 1260             


Asp His  Tyr Asn Asp Leu Tyr  Gln Leu Leu Ser Tyr  Ile Glu Arg 
    1265                 1270                 1275             


Phe Ala  Ser Leu Tyr Val Asp  Val Glu Lys Asn Ile  Ser Lys Val 
    1280                 1285                 1290             


Lys Glu  Leu Phe Ser Asn Ile  Glu Ser Tyr Ser Ile  Ser Glu Ile 
    1295                 1300                 1305             


Cys Ser  Ser Val Ile Asn Leu  Leu Thr Leu Thr Ala  Ser Gly Ala 
    1310                 1315                 1320             


Pro Ala  Asp Phe Lys Phe Leu  Gly Thr Thr Ile Pro  Arg Lys Arg 
    1325                 1330                 1335             


Tyr Gly  Ser Pro Gln Ser Ile  Leu Ser Ser Thr Leu  Ile His Gln 
    1340                 1345                 1350             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu 
    1355                 1360                 1365             


Gly Gly  Asp 
    1370     


<210> 453
<211> 1371
<212> PRT
<213> Streptococcus dysgalactiae

<400> 453
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Ser Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Met Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Arg Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Glu Phe Leu Ser Gly Lys Gln 
    530                 535                 540                 


Lys Glu Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Lys Glu Met Ile Glu Glu Arg Leu Lys Lys Tyr Ala 
625                 630                 635                 640 


Asn Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Ala Ile Gln Lys Ala Gln Val Ser Gly Gln Gly His Ser Leu 
705                 710                 715                 720 


His Glu Gln Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Ile Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Thr Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Arg  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Glu Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Ala Leu Thr  Asn Glu Ser Ile Tyr  Ala Arg Gly 
    1100                 1105                 1110             


Ser Phe  Asp Lys Leu Ile Ser  Arg Lys His Arg Phe  Glu Ser Ser 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Gly Ser  Pro Thr Val Thr Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Ser Lys Val  Gln Asp Gly Lys Val  Lys Lys Ile 
    1145                 1150                 1155             


Lys Thr  Gly Lys Glu Leu Ile  Gly Met Thr Leu Leu  Asp Lys Leu 
    1160                 1165                 1170             


Val Phe  Glu Lys Asn Pro Leu  Lys Phe Ile Glu Asp  Lys Gly Tyr 
    1175                 1180                 1185             


Gly Asn  Val Gln Ile Asp Lys  Cys Ile Lys Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Phe Glu Asn Gly  Thr Arg Arg Met Leu  Ala Ser Val 
    1205                 1210                 1215             


Met Ala  Asn Asn Asn Ser Arg  Gly Asp Leu Gln Lys  Ala Asn Glu 
    1220                 1225                 1230             


Met Phe  Leu Pro Ala Lys Leu  Val Thr Leu Leu Tyr  His Ala His 
    1235                 1240                 1245             


Lys Ile  Glu Ser Ser Lys Glu  Leu Glu His Glu Ala  Tyr Ile Leu 
    1250                 1255                 1260             


Asp His  Tyr Asn Asp Leu Tyr  Gln Leu Leu Ser Tyr  Ile Glu Arg 
    1265                 1270                 1275             


Phe Ala  Ser Leu Tyr Val Asp  Val Glu Lys Asn Ile  Ser Lys Val 
    1280                 1285                 1290             


Lys Glu  Leu Phe Ser Asn Ile  Glu Ser Tyr Ser Ile  Ser Glu Ile 
    1295                 1300                 1305             


Cys Ser  Ser Val Ile Asn Leu  Leu Thr Leu Thr Ala  Ser Gly Ala 
    1310                 1315                 1320             


Pro Ala  Asp Phe Lys Phe Leu  Gly Thr Thr Ile Pro  Arg Lys Arg 
    1325                 1330                 1335             


Tyr Gly  Ser Pro Gln Ser Ile  Leu Ser Ser Thr Leu  Ile His Gln 
    1340                 1345                 1350             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu 
    1355                 1360                 1365             


Gly Gly  Asp 
    1370     


<210> 454
<211> 1371
<212> PRT
<213> Streptococcus dysgalactiae

<400> 454
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Ser Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Met Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Arg Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Glu Phe Leu Ser Gly Lys Gln 
    530                 535                 540                 


Lys Glu Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Lys Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Ile Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Ala Ile Gln Lys Ala Gln Val Ser Gly Gln Gly His Ser Leu 
705                 710                 715                 720 


His Glu Gln Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asp Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Arg  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Glu Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asn Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Ala Leu Thr  Asn Glu Ser Ile Tyr  Ala Arg Gly 
    1100                 1105                 1110             


Ser Phe  Asp Lys Leu Ile Ser  Arg Lys His Arg Phe  Glu Ser Ser 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Gly Ser  Pro Thr Val Thr Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Ser Lys Val  Gln Asp Gly Lys Val  Lys Lys Ile 
    1145                 1150                 1155             


Lys Thr  Gly Lys Glu Leu Ile  Gly Ile Thr Leu Leu  Asp Lys Leu 
    1160                 1165                 1170             


Val Phe  Glu Lys Asn Pro Leu  Lys Phe Ile Glu Asp  Lys Gly Tyr 
    1175                 1180                 1185             


Gly Asn  Val Gln Ile Asp Lys  Cys Ile Lys Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Phe Glu Asn Gly  Thr Arg Arg Met Leu  Ala Ser Val 
    1205                 1210                 1215             


Met Ala  Asn Asn Asn Ser Arg  Gly Asp Leu Gln Lys  Ala Asn Glu 
    1220                 1225                 1230             


Met Phe  Leu Pro Ala Lys Leu  Val Thr Leu Leu Tyr  His Ala His 
    1235                 1240                 1245             


Lys Ile  Glu Ser Ser Lys Glu  Leu Glu His Glu Ala  Tyr Ile Leu 
    1250                 1255                 1260             


Asp His  Tyr Asn Asp Leu Tyr  Gln Leu Leu Ser Tyr  Ile Glu Arg 
    1265                 1270                 1275             


Phe Ala  Ser Leu Tyr Val Asp  Val Glu Lys Asn Ile  Ser Lys Val 
    1280                 1285                 1290             


Lys Glu  Leu Phe Ser Asn Ile  Glu Ser Tyr Ser Ile  Ser Glu Ile 
    1295                 1300                 1305             


Cys Ser  Ser Val Ile Asn Leu  Leu Thr Leu Thr Ala  Ser Gly Ala 
    1310                 1315                 1320             


Pro Ala  Asp Phe Lys Phe Leu  Gly Thr Thr Ile Pro  Arg Lys Arg 
    1325                 1330                 1335             


Tyr Gly  Ser Pro Gln Ser Ile  Leu Ser Ser Thr Leu  Ile His Gln 
    1340                 1345                 1350             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu 
    1355                 1360                 1365             


Gly Gly  Asp 
    1370     


<210> 455
<211> 1348
<212> PRT
<213> Streptococcus equi

<400> 455
Met Lys Lys Pro Tyr Thr Ile Ala Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Val Val Val Thr Asp Asp Tyr Arg Val Pro Thr Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Glu Arg Lys Thr Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asp Thr Ala Glu Gly Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Lys Glu Ile Phe Thr Glu Glu Met Ala Lys Val Asp Asp Gly 
                85                  90                  95      


Phe Phe Gln Arg Leu Glu Asp Ser Phe Tyr Val Leu Glu Asp Lys Glu 
            100                 105                 110         


Gly Asn Lys His Pro Ile Phe Ala Asn Leu Ala Asp Glu Val Ala Tyr 
        115                 120                 125             


His Lys Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Val Asp 
    130                 135                 140                 


Asn Pro Gln Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Val Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Thr Leu Ser Ser 
                165                 170                 175     


Lys Asn Asn Asn Leu Gln Lys Ser Phe Asp His Leu Val Asp Thr Tyr 
            180                 185                 190         


Asn Leu Leu Phe Glu Glu Gln Arg Leu Leu Thr Glu Gly Ile Asn Ala 
        195                 200                 205             


Lys Glu Leu Leu Ser Ala Ala Leu Ser Lys Ser Lys Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ser Leu Ile Pro Gly Gln Lys Lys Thr Gly Ile Phe Gly Asn 
225                 230                 235                 240 


Ile Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ala Asn Phe 
                245                 250                 255     


Gly Leu Ser Lys Asp Val Lys Leu Gln Leu Ala Lys Asp Thr Tyr Ala 
            260                 265                 270         


Asp Asp Leu Asp Ser Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Thr Glu Ser Asp Glu Ile Thr Arg Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Arg Glu His His Lys Asp Leu Val Thr Leu Lys 
                325                 330                 335     


Thr Leu Ile Lys Asp Gln Leu Pro Glu Lys Tyr Gln Glu Ile Phe Leu 
            340                 345                 350         


Asp Lys Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Gly Gln Val Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Tyr Leu Lys Pro Ile Leu Ala Arg Leu Asp 
    370                 375                 380                 


Gly Ser Glu Pro Leu Leu Leu Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Glu Glu Leu His Ala Ile Leu Arg Arg Gln Glu Val Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Lys Lys Ile Glu Ser Leu Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly His Ser Arg Phe Ala Trp 
    450                 455                 460                 


Val Lys Arg Lys Phe Asp Gly Ala Ile Arg Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Ile Val Asp Glu Glu Ala Ser Ala Gln Ile Phe Ile Glu Lys Met Thr 
                485                 490                 495     


Lys Asn Asp Leu Tyr Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Ala Thr Glu Gly Met Thr Arg Pro Gln Phe Leu Ser Ala Asp Gln 
    530                 535                 540                 


Lys Gln Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asn Tyr Phe Lys Lys Ile Glu Cys Trp Asp 
                565                 570                 575     


Ser Val Glu Ile Thr Gly Val Glu Asp Ser Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Gln Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Pro Asp Asn Gln Lys Ile Ile Glu Asp Ile Ile Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Lys Lys Met Ile Ser Lys Arg Leu Asp Gln Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Lys Val Val Leu Asn Lys Leu Glu Arg His His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Gly Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ala Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Ser Glu Leu Ser Phe 
    690                 695                 700                 


Ile Asp Glu Ile Ala Lys Ala Gln Val Ile Gly Lys Thr Glu Tyr Ser 
705                 710                 715                 720 


Lys Asp Leu Val Gly Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Ser Gln Thr Ile Lys Ile Val Asp Glu Leu Val Lys Ile Met Gly 
            740                 745                 750         


Tyr Leu Pro Gln Gln Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Ala Gln Gly Ile Lys Asn Ala Arg Gln Arg Met Arg Lys Leu Glu 
    770                 775                 780                 


Glu Thr Ala Lys Lys Leu Gly Ser Asn Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Asp Asn Ser Gln Leu Gln Asn Asp Lys Arg Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Lys Asp Met Tyr Thr Gly Asp Asp Leu Asp Ile Asp Tyr Leu 
            820                 825                 830         


Ser Ser Tyr Asp Ile Asp His Ile Ile Pro Gln Ser Phe Ile Lys Asn 
        835                 840                 845             


Asn Ser Ile Asp Asn Lys Val Leu Thr Ser Gln Gly Ala Asn Arg Gly 
    850                 855                 860                 


Lys Leu Asp Asn Val Pro Ser Glu Ala Ile Val Arg Lys Met Lys Gly 
865                 870                 875                 880 


Tyr Trp Gln Ser Leu Leu Arg Ala Gly Ala Ile Ser Lys Gln Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Gln Val Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Gln Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Phe Asn Thr Glu Phe Asp Asp 
    930                 935                 940                 


His Asn Lys Arg Ile Arg Lys Val His Ile Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Glu Phe Gly Leu Tyr Lys Ile Arg Asp 
                965                 970                 975     


Ile Asn His Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Ala Lys Ala Ile Leu Gly Lys Tyr  Pro Gln Leu Ala Pro  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Pro Lys Tyr  Asn Ser Phe Lys Glu  Arg Gln Lys 
    1010                 1015                 1020             


Ala Thr  Gln Lys Met Leu Phe  Tyr Ser Asn Ile Leu  Lys Phe Phe 
    1025                 1030                 1035             


Lys Asp  Gln Glu Ser Leu His  Val Asn Ser Asp Gly  Glu Glu Ile 
    1040                 1045                 1050             


Trp Asn  Ala Asn Lys His Leu  Pro Ile Ile Lys Asn  Val Leu Ser 
    1055                 1060                 1065             


Ile Pro  Gln Val Asn Ile Val  Lys Lys Thr Glu Val  Gln Thr Gly 
    1070                 1075                 1080             


Gly Phe  Tyr Lys Glu Ser Ile  Leu Ser Lys Gly Asn  Ser Asp Lys 
    1085                 1090                 1095             


Leu Ile  Pro Arg Lys Asn Asn  Trp Asp Thr Arg Lys  Tyr Gly Gly 
    1100                 1105                 1110             


Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val Leu Val  Ile Ala Lys 
    1115                 1120                 1125             


Met Glu  Lys Gly Lys Ala Lys  Val Leu Lys Pro Val  Lys Glu Met 
    1130                 1135                 1140             


Val Gly  Ile Thr Ile Met Glu  Arg Thr Ala Phe Glu  Glu Asn Pro 
    1145                 1150                 1155             


Val Val  Phe Leu Glu Ala Arg  Gly Tyr Arg Glu Ile  Gln Glu His 
    1160                 1165                 1170             


Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn 
    1175                 1180                 1185             


Gly Arg  Arg Arg Leu Leu Ala  Ser Ala Ser Glu Leu  Gln Lys Gly 
    1190                 1195                 1200             


Asn Glu  Leu Phe Leu Pro Val  Asp Tyr Met Thr Phe  Leu Tyr Leu 
    1205                 1210                 1215             


Ala Ala  His Tyr His Glu Leu  Thr Gly Ser Ser Glu  Asp Val Leu 
    1220                 1225                 1230             


Arg Lys  Lys Tyr Phe Val Asp  Arg His Leu His Tyr  Phe Asp Asp 
    1235                 1240                 1245             


Ile Ile  Gln Met Ile Asn Asp  Phe Ala Glu Arg His  Ile Leu Ala 
    1250                 1255                 1260             


Ser Ser  Asn Leu Glu Lys Ile  Asn His Thr Tyr His  Asn Asn Ser 
    1265                 1270                 1275             


Asp Leu  Pro Val Asn Glu Arg  Ala Glu Asn Ile Ile  Asn Val Phe 
    1280                 1285                 1290             


Thr Phe  Val Ala Leu Gly Ala  Pro Ala Ala Phe Lys  Phe Phe Asp 
    1295                 1300                 1305             


Ala Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser Thr Lys  Glu Val Leu 
    1310                 1315                 1320             


Asn Ala  Thr Leu Ile His Gln  Ser Val Thr Gly Leu  Tyr Glu Thr 
    1325                 1330                 1335             


Arg Ile  Asp Leu Ser Gln Leu  Gly Glu Asn 
    1340                 1345             


<210> 456
<211> 1377
<212> PRT
<213> Streptococcus equinus


<220>
<223> Streptococcus equinus ATCC 9812

<400> 456
Met Glu Lys Thr Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Lys Tyr Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Ala Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Lys Glu Met Ala Lys Val Asp Glu Ser 
                85                  90                  95      


Phe Phe Gln Arg Leu Glu Glu Ser Phe Leu Thr Asp Asp Asp Lys Thr 
            100                 105                 110         


Phe Asp Ser His Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Thr Tyr 
        115                 120                 125             


His Gln Glu Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ser Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Gln Leu Asn Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Lys Ile Phe Ala Asp Phe Val Gly Val Tyr 
            180                 185                 190         


Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Ala Ser Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Lys Gln Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Val Ala Leu Ala Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Thr Ala Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Asp Asp Asn Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Glu Glu His His Glu Asp Leu Glu Lys Leu Lys 
                325                 330                 335     


Thr Phe Ile Lys Val Asn Asn Phe Asp Lys Tyr His Glu Ile Phe Lys 
            340                 345                 350         


Asp Lys Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val Lys 
        355                 360                 365             


Gln Asp Ile Phe Tyr Lys His Leu Lys Ser Ile Ile Ser Glu Lys Asn 
    370                 375                 380                 


Gly Gly Gln Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Thr Ile Leu Arg Arg Gln Gly Glu Tyr Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Ala Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Ala Lys Tyr His Ser Asp Glu Pro Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Val Val Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met Thr 
                485                 490                 495     


Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Tyr Val Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Ile Lys 
        515                 520                 525             


Tyr Val Asn Glu Gln Gly Lys Ser Phe Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys Val Thr Lys 
545                 550                 555                 560 


Ala Lys Leu Leu Ser Tyr Leu Asn Asn Glu Phe Glu Glu Phe Arg Ile 
                565                 570                 575     


Asn Asp Leu Ile Gly Leu Asp Lys Asp Ser Lys Ser Phe Asn Ala Ser 
            580                 585                 590         


Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Ser Phe Leu 
        595                 600                 605             


Asp Asp Lys Thr Asn Glu Gln Ile Ile Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Asp Met Ile His Glu Arg Leu Gln Lys Tyr 
625                 630                 635                 640 


Ser Asp Ile Phe Thr Ser Gln Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Asn Asn Lys Thr Ile Leu Asp Phe Leu Ile Asp Asp Gly 
        675                 680                 685             


Asp Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ser Leu Ser 
    690                 695                 700                 


Phe Lys Thr Thr Ile Gln Glu Ala Gln Val Val Gly Asp Val Asp Asp 
705                 710                 715                 720 


Ile Glu Ala Val Val His Asp Leu Pro Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly His Asn Pro Gln Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Ile Thr Gly Tyr Gly Arg Asn Arg Ser Asn Gln Arg Leu Lys Arg Leu 
    770                 775                 780                 


Gln Asp Ser Leu Lys Glu Phe Gly Ser Asp Ile Leu Ser Lys Lys Lys 
785                 790                 795                 800 


Pro Ser Tyr Val Asp Ser Lys Val Glu Asn Ser His Leu Gln Asn Asp 
                805                 810                 815     


Arg Leu Phe Leu Tyr Tyr Ile Gln Asn Gly Lys Asp Met Tyr Thr Gly 
            820                 825                 830         


Glu Glu Leu Asp Ile Asp His Leu Ser Asp Tyr Asp Ile Asp His Ile 
        835                 840                 845             


Ile Pro Gln Ala Phe Ile Lys Asp Asn Ser Ile Asp Asn Arg Val Leu 
    850                 855                 860                 


Thr Ser Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Ile 
865                 870                 875                 880 


Glu Ile Val Arg Asn Arg Lys Ser Tyr Trp Tyr Lys Leu Tyr Lys Ser 
                885                 890                 895     


Gly Leu Ile Ser Lys Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 
            900                 905                 910         


Gly Gly Leu Thr Glu Thr Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu 
        915                 920                 925             


Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ala 
    930                 935                 940                 


Arg Phe Asn Thr Lys Cys Asp Glu Asn Asp Lys Val Ile Arg Asp Val 
945                 950                 955                 960 


Lys Val Ile Thr Leu Lys Ser Ser Leu Val Ser Gln Phe Arg Lys Glu 
                965                 970                 975     


Phe Lys Phe Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His 
            980                 985                 990         


Asp Ala Tyr Leu Asn Ala Val Val  Gly Thr Ala Leu Leu  Lys Lys Tyr 
        995                 1000                 1005             


Pro Lys  Leu Ala Pro Glu Phe  Val Tyr Gly Glu Tyr  Lys Lys Tyr 
    1010                 1015                 1020             


Asp Val  Arg Lys Leu Val Ala  Lys Ser Ser Asp Asn  His Ser Glu 
    1025                 1030                 1035             


Leu Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe Tyr Ser  Asn Leu Met 
    1040                 1045                 1050             


Asn Phe  Phe Lys Thr Glu Val  Lys Tyr Ala Asp Gly  Arg Val Phe 
    1055                 1060                 1065             


Glu Arg  Pro Asp Ile Glu Thr  Asn Ala Asp Gly Glu  Val Val Trp 
    1070                 1075                 1080             


Asn Lys  Gln Arg Asp Phe Asn  Ile Val Arg Lys Val  Leu Ser Tyr 
    1085                 1090                 1095             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Val Gln  Thr Gly Gly 
    1100                 1105                 1110             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asp Ser  Asp Lys Leu 
    1115                 1120                 1125             


Ile Pro  Arg Lys Thr Lys Lys  Leu Gln Trp Glu Thr  Gln Lys Tyr 
    1130                 1135                 1140             


Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr Ser Val  Leu Val Val 
    1145                 1150                 1155             


Ala Asp  Val Glu Lys Gly Lys  Thr Arg Lys Leu Lys  Thr Val Lys 
    1160                 1165                 1170             


Glu Leu  Val Gly Ile Ser Ile  Met Glu Arg Ser Ser  Phe Glu Glu 
    1175                 1180                 1185             


Asn Pro  Val Ser Phe Leu Glu  Lys Lys Gly Tyr His  Asn Val Gln 
    1190                 1195                 1200             


Glu Asp  Lys Leu Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Phe 
    1205                 1210                 1215             


Glu Gly  Gly Arg Arg Arg Leu  Leu Ala Ser Ala Thr  Glu Leu Gln 
    1220                 1225                 1230             


Lys Gly  Asn Glu Val Val Leu  Pro Gln Tyr Met Val  Asn Leu Leu 
    1235                 1240                 1245             


Tyr His  Ser Gln His Val Asn  Asn Ser His Lys Pro  Glu His Leu 
    1250                 1255                 1260             


Asn Tyr  Val Lys Gln His Lys  Asp Glu Phe Lys Asp  Ile Phe Asn 
    1265                 1270                 1275             


Leu Ile  Ile Ser Ile Ala Arg  Ile Asn Ile Leu Lys  Pro Lys Val 
    1280                 1285                 1290             


Val Asp  Asn Leu Ile Asn Glu  Phe Thr Glu Tyr Gly  Gln Glu Asp 
    1295                 1300                 1305             


Ile Ser  Ser Leu Ser Glu Ser  Phe Ile Asn Leu Leu  Lys Phe Ile 
    1310                 1315                 1320             


Ser Phe  Gly Ala Pro Gly Ala  Phe Lys Phe Leu Lys  Leu Asp Val 
    1325                 1330                 1335             


Lys Gln  Ser Asn Leu Arg Tyr  Lys Ser Thr Thr Glu  Ala Leu Ser 
    1340                 1345                 1350             


Ala Thr  Leu Ile His Gln Ser  Val Thr Gly Leu Tyr  Glu Thr Arg 
    1355                 1360                 1365             


Ile Asp  Leu Ser Lys Leu Gly  Glu Glu 
    1370                 1375         


<210> 457
<211> 1370
<212> PRT
<213> Streptococcus gallolyticus

<400> 457
Met Thr Lys Lys Asn Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys Lys Tyr Ile Lys Lys Asn Leu 
        35                  40                  45              


Leu Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Thr Lys Val Asp Glu 
                85                  90                  95      


Ser Phe Phe Tyr Arg Leu Asp Glu Ser Phe Leu Thr Thr Asp Glu Lys 
            100                 105                 110         


Asp Phe Glu Arg His Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala 
        115                 120                 125             


Tyr His Gln Lys Phe Pro Thr Ile Tyr His Leu Arg Asn Tyr Leu Ala 
    130                 135                 140                 


Asp Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Asn 
                165                 170                 175     


Ala Glu Asn Thr Asp Val Gln Lys Leu Phe Thr Asp Phe Val Gly Val 
            180                 185                 190         


Tyr Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp 
        195                 200                 205             


Val Ala Ser Thr Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu 
    210                 215                 220                 


Asn Leu Ile Lys Tyr Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly 
225                 230                 235                 240 


Asn Leu Ile Ala Leu Ala Leu Gly Leu Gln Pro Asn Phe Lys Met Asn 
                245                 250                 255     


Phe Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr 
            260                 265                 270         


Glu Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala 
        275                 280                 285             


Asp Leu Phe Thr Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Asp Asp Asn Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Lys Arg Tyr Val Glu His His Glu Asp Leu Glu Lys Leu 
                325                 330                 335     


Lys Glu Phe Ile Lys Ala Asn Lys Ser Glu Leu Tyr His Asp Ile Phe 
            340                 345                 350         


Lys Asp Lys Asn Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val 
        355                 360                 365             


Lys Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Asn Thr Leu Ser Lys Ile 
    370                 375                 380                 


Asp Gly Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Asp Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Lys Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Val Arg Lys Asp Ser Arg Phe Ala 
    450                 455                 460                 


Trp Ala Glu Tyr Arg Ser Asp Glu Lys Ile Thr Pro Trp Asn Phe Asp 
465                 470                 475                 480 


Lys Val Ile Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met 
                485                 490                 495     


Thr Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser His Val Tyr Glu Thr Tyr Ala Val Tyr Asn Glu Leu Thr Lys Ile 
        515                 520                 525             


Lys Tyr Val Asn Glu Gln Gly Lys Glu Ser Phe Phe Asp Ser Asn Met 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys Val Thr 
545                 550                 555                 560 


Lys Glu Lys Leu Leu Asn Tyr Leu Asn Lys Glu Phe Pro Glu Tyr Arg 
                565                 570                 575     


Ile Lys Asp Leu Ile Gly Leu Asp Lys Glu Asn Lys Ser Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Ala Phe 
        595                 600                 605             


Leu Asp Asp Lys Val Asn Glu Glu Val Ile Glu Asp Ile Ile Lys Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Lys Asp Met Ile His Glu Arg Leu Gln Lys 
625                 630                 635                 640 


Tyr Ser Asp Ile Phe Thr Ala Asn Gln Leu Lys Lys Leu Glu Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asn Lys Glu Asn Asn Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Ser Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Thr Leu 
    690                 695                 700                 


Pro Phe Lys Gln Ile Ile Gln Lys Ser Gln Val Val Gly Asp Val Asp 
705                 710                 715                 720 


Asp Ile Glu Ala Val Val His Asp Leu Pro Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Asp Asn Pro Asp Asn Ile Val Ile Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Arg Gly Arg Ser Gln Ser Gln Gln Arg Leu Lys Lys 
    770                 775                 780                 


Leu Gln Ser Ser Leu Lys Glu Leu Gly Ser Asn Ile Leu Asn Glu Glu 
785                 790                 795                 800 


Lys Pro Ser Tyr Ile Glu Asp Lys Val Glu Asn Ser His Leu Gln Asn 
                805                 810                 815     


Asp Gln Leu Phe Leu Tyr Tyr Ile Gln Asn Gly Lys Asp Met Tyr Thr 
            820                 825                 830         


Gly Asp Glu Leu Asp Ile Asp His Leu Ser Asp Tyr Asp Ile Asp His 
        835                 840                 845             


Ile Ile Pro Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val 
    850                 855                 860                 


Leu Thr Ser Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser 
865                 870                 875                 880 


Leu Asp Ile Val Arg Ala Arg Lys Ala Glu Trp Val Arg Leu Tyr Lys 
                885                 890                 895     


Ser Gly Leu Ile Ser Lys Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu 
            900                 905                 910         


Arg Gly Gly Leu Thr Glu Ala Asp Lys Ala Gly Phe Ile Lys Arg Gln 
        915                 920                 925             


Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp 
    930                 935                 940                 


Ala Arg Phe Asn Thr Glu His Asp Glu Asn Asp Lys Val Ile Arg Asp 
945                 950                 955                 960 


Val Lys Val Ile Thr Leu Lys Ser Asn Leu Val Ser Gln Phe Arg Lys 
                965                 970                 975     


Asp Phe Glu Phe Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His Ala 
            980                 985                 990         


His Asp Ala Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Leu Lys Lys 
        995                 1000                 1005             


Tyr Pro  Lys Leu Ala Ser Glu  Phe Val Tyr Gly Glu  Tyr Lys Lys 
    1010                 1015                 1020             


Tyr Asp  Ile Arg Lys Phe Ile  Thr Asn Ser Ser Asp  Lys Ala Thr 
    1025                 1030                 1035             


Ala Lys  Tyr Phe Phe Tyr Ser  Asn Leu Met Asn Phe  Phe Lys Thr 
    1040                 1045                 1050             


Lys Val  Lys Tyr Ala Asp Gly  Thr Val Phe Glu Arg  Pro Ile Ile 
    1055                 1060                 1065             


Glu Thr  Asn Ala Asp Gly Glu  Ile Ala Trp Asn Lys  Gln Ile Asp 
    1070                 1075                 1080             


Phe Glu  Lys Val Arg Lys Val  Leu Ser Tyr Pro Gln  Val Asn Ile 
    1085                 1090                 1095             


Val Lys  Lys Val Glu Thr Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1100                 1105                 1110             


Ile Leu  Pro Lys Gly Asp Ser  Asp Lys Leu Ile Pro  Arg Lys Thr 
    1115                 1120                 1125             


Lys Lys  Val Tyr Trp Asp Thr  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    1130                 1135                 1140             


Pro Thr  Val Ala Tyr Ser Val  Phe Val Val Ala Asp  Val Glu Lys 
    1145                 1150                 1155             


Gly Lys  Ala Lys Lys Leu Lys  Thr Val Lys Glu Leu  Val Gly Ile 
    1160                 1165                 1170             


Ser Ile  Met Glu Arg Ser Phe  Phe Glu Glu Asn Pro  Val Glu Phe 
    1175                 1180                 1185             


Leu Glu  Asn Lys Gly Tyr His  Asn Ile Arg Glu Asp  Lys Leu Ile 
    1190                 1195                 1200             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Phe Glu Gly  Gly Arg Arg 
    1205                 1210                 1215             


Arg Leu  Leu Ala Ser Ala Ser  Glu Leu Gln Lys Gly  Asn Glu Met 
    1220                 1225                 1230             


Val Leu  Pro Gly Tyr Leu Val  Glu Leu Leu Tyr His  Ala His Arg 
    1235                 1240                 1245             


Ala Asp  Asn Phe Asn Ser Thr  Glu Tyr Leu Asn Tyr  Val Ser Glu 
    1250                 1255                 1260             


His Lys  Lys Glu Phe Glu Lys  Val Leu Ser Cys Val  Glu Asp Phe 
    1265                 1270                 1275             


Ala Asn  Leu Tyr Val Asp Val  Glu Lys Asn Leu Ser  Lys Ile Arg 
    1280                 1285                 1290             


Ala Val  Ala Asp Ser Met Asp  Asn Phe Ser Ile Glu  Glu Ile Ser 
    1295                 1300                 1305             


Asn Ser  Phe Ile Asn Leu Leu  Thr Leu Thr Ala Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Asp  Phe Asn Phe Leu Gly  Glu Lys Ile Pro Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Cys Leu  Thr Ala Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Lys Leu Gly 
    1355                 1360                 1365             


Glu Glu  
    1370 


<210> 458
<211> 1370
<212> PRT
<213> Streptococcus gallolyticus


<220>
<223> Streptococcus gallolyticus subsp. gallolyticus TX20005

<400> 458
Met Thr Lys Lys Asn Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys Lys Tyr Ile Lys Lys Asn Leu 
        35                  40                  45              


Leu Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Thr Lys Val Asp Glu 
                85                  90                  95      


Ser Phe Phe Tyr Arg Leu Asp Glu Ser Phe Leu Thr Thr Asp Glu Lys 
            100                 105                 110         


Asp Phe Glu Arg His Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala 
        115                 120                 125             


Tyr His Gln Lys Phe Pro Thr Ile Tyr His Leu Arg Asn Tyr Leu Ala 
    130                 135                 140                 


Asp Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Asn 
                165                 170                 175     


Ala Glu Asn Thr Asp Val Gln Lys Leu Phe Thr Asp Phe Val Gly Val 
            180                 185                 190         


Tyr Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp 
        195                 200                 205             


Val Ala Ser Thr Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu 
    210                 215                 220                 


Asn Leu Ile Lys Tyr Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly 
225                 230                 235                 240 


Asn Leu Ile Ala Leu Ala Leu Gly Leu Gln Pro Asn Phe Lys Met Asn 
                245                 250                 255     


Phe Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr 
            260                 265                 270         


Glu Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala 
        275                 280                 285             


Asp Leu Phe Thr Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Asp Asp Asn Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Lys Arg Tyr Val Glu His His Glu Asp Leu Glu Lys Leu 
                325                 330                 335     


Lys Glu Phe Ile Lys Ala Asn Lys Ser Glu Leu Tyr His Asp Ile Phe 
            340                 345                 350         


Lys Asp Lys Asn Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val 
        355                 360                 365             


Lys Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Asn Thr Leu Ser Lys Ile 
    370                 375                 380                 


Asp Gly Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Asp Tyr Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Lys Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Val Arg Lys Asp Ser Arg Phe Ala 
    450                 455                 460                 


Trp Ala Glu Tyr Arg Ser Asp Glu Lys Ile Thr Pro Trp Asn Phe Asp 
465                 470                 475                 480 


Lys Val Ile Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met 
                485                 490                 495     


Thr Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser His Val Tyr Glu Thr Tyr Ala Val Tyr Asn Glu Leu Thr Lys Ile 
        515                 520                 525             


Lys Tyr Val Asn Glu Gln Gly Lys Glu Ser Phe Phe Asp Ser Asn Met 
    530                 535                 540                 


Lys Gln Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys Val Thr 
545                 550                 555                 560 


Lys Glu Lys Leu Leu Asn Tyr Leu Asn Lys Glu Phe Pro Glu Tyr Arg 
                565                 570                 575     


Ile Lys Asp Leu Ile Gly Leu Asp Lys Glu Asn Lys Ser Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Ala Phe 
        595                 600                 605             


Leu Asp Asp Lys Val Asn Glu Glu Val Ile Glu Asp Ile Ile Lys Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Lys Asp Met Ile His Glu Arg Leu Gln Lys 
625                 630                 635                 640 


Tyr Ser Asp Ile Phe Thr Ala Asn Gln Leu Lys Lys Leu Glu Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asn Lys Glu Asn Asn Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Ser Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Thr Leu 
    690                 695                 700                 


Pro Phe Lys Gln Ile Ile Gln Lys Ser Gln Val Val Gly Asp Val Asp 
705                 710                 715                 720 


Asp Ile Glu Ala Val Val His Asp Leu Pro Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Asp Asn Pro Asp Asn Ile Val Ile Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Arg Gly Arg Ser Gln Ser Gln Gln Arg Leu Lys Lys 
    770                 775                 780                 


Leu Gln Ser Ser Leu Lys Glu Leu Gly Ser Asn Ile Leu Asn Glu Glu 
785                 790                 795                 800 


Lys Pro Ser Tyr Ile Glu Asp Lys Val Glu Asn Ser His Leu Gln Asn 
                805                 810                 815     


Asp Gln Leu Phe Leu Tyr Tyr Ile Gln Asn Gly Lys Asp Met Tyr Thr 
            820                 825                 830         


Gly Asp Glu Leu Asp Ile Asp His Leu Ser Asp Tyr Asp Ile Asp His 
        835                 840                 845             


Ile Ile Pro Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val 
    850                 855                 860                 


Leu Thr Ser Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser 
865                 870                 875                 880 


Leu Asp Ile Val Arg Ala Arg Lys Ala Glu Trp Val Arg Leu Tyr Lys 
                885                 890                 895     


Ser Gly Leu Ile Ser Lys Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu 
            900                 905                 910         


Arg Gly Gly Leu Thr Glu Ala Asp Lys Ala Gly Phe Ile Lys Arg Gln 
        915                 920                 925             


Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp 
    930                 935                 940                 


Ala Arg Phe Asn Thr Glu His Asp Glu Asn Asp Lys Val Ile Arg Asp 
945                 950                 955                 960 


Val Lys Val Ile Thr Leu Lys Ser Asn Leu Val Ser Gln Phe Arg Lys 
                965                 970                 975     


Asp Phe Glu Phe Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His Ala 
            980                 985                 990         


His Asp Ala Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Leu Lys Lys 
        995                 1000                 1005             


Tyr Pro  Lys Leu Ala Ser Glu  Phe Val Tyr Gly Glu  Tyr Lys Lys 
    1010                 1015                 1020             


Tyr Asp  Ile Arg Lys Phe Ile  Thr Asn Ser Ser Asp  Lys Ala Thr 
    1025                 1030                 1035             


Ala Lys  Tyr Phe Phe Tyr Ser  Asn Leu Met Asn Phe  Phe Lys Thr 
    1040                 1045                 1050             


Lys Val  Lys Tyr Ala Asp Gly  Thr Val Phe Glu Arg  Pro Ile Ile 
    1055                 1060                 1065             


Glu Thr  Asn Ala Asp Gly Glu  Ile Ala Trp Asn Lys  Gln Ile Asp 
    1070                 1075                 1080             


Phe Glu  Lys Val Arg Lys Val  Leu Ser Tyr Pro Gln  Val Asn Ile 
    1085                 1090                 1095             


Val Lys  Lys Val Glu Thr Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1100                 1105                 1110             


Ile Leu  Pro Lys Gly Asp Ser  Asp Lys Leu Ile Pro  Arg Lys Thr 
    1115                 1120                 1125             


Lys Lys  Val Tyr Trp Asp Thr  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    1130                 1135                 1140             


Pro Thr  Val Ala Tyr Ser Val  Phe Val Val Ala Asp  Val Glu Lys 
    1145                 1150                 1155             


Gly Lys  Ala Lys Lys Leu Lys  Thr Val Lys Glu Leu  Val Gly Ile 
    1160                 1165                 1170             


Ser Ile  Met Glu Arg Ser Phe  Phe Glu Glu Asn Pro  Val Glu Phe 
    1175                 1180                 1185             


Leu Glu  Asn Lys Gly Tyr His  Asn Ile Arg Glu Asp  Lys Leu Ile 
    1190                 1195                 1200             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Phe Glu Gly  Gly Arg Arg 
    1205                 1210                 1215             


Arg Leu  Leu Ala Ser Ala Ser  Glu Leu Gln Lys Gly  Asn Glu Met 
    1220                 1225                 1230             


Val Leu  Pro Gly Tyr Leu Val  Glu Leu Leu Tyr His  Ala His Arg 
    1235                 1240                 1245             


Ala Asp  Asn Phe Asn Ser Thr  Glu Tyr Leu Asn Tyr  Val Ser Glu 
    1250                 1255                 1260             


His Lys  Lys Glu Phe Glu Lys  Val Leu Ser Cys Val  Glu Asp Phe 
    1265                 1270                 1275             


Ala Asn  Leu Tyr Val Asp Val  Glu Lys Asn Leu Ser  Lys Ile Arg 
    1280                 1285                 1290             


Ala Val  Ala Asp Ser Met Asp  Asn Phe Ser Ile Glu  Glu Ile Ser 
    1295                 1300                 1305             


Asn Ser  Phe Ile Asn Leu Leu  Thr Leu Thr Ala Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Asp  Phe Asn Phe Leu Gly  Glu Lys Ile Pro Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Ser  Thr Lys Glu Cys Leu  Thr Ala Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Lys Leu Gly 
    1355                 1360                 1365             


Glu Glu  
    1370 


<210> 459
<211> 1371
<212> PRT
<213> Streptococcus gallolyticus

<400> 459
Met Thr Glu Lys Asn Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys Lys Tyr Ile Lys Lys Asn Leu 
        35                  40                  45              


Leu Gly Ala Leu Leu Phe Asp Asn Gly Glu Thr Ala Glu Ala Thr Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ala Lys Val Asp Glu 
                85                  90                  95      


Ser Phe Phe Tyr Arg Leu Asp Glu Ser Phe Leu Thr Thr Asp Asp Lys 
            100                 105                 110         


Asp Phe Glu Arg His Pro Ile Phe Gly Asn Lys Ala Asp Glu Ile Lys 
        115                 120                 125             


Tyr His Gln Glu Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala 
    130                 135                 140                 


Asp Ser His Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn 
                165                 170                 175     


Ala Glu Asn Thr Asp Val Gln Lys Leu Phe Glu Ala Phe Val Glu Val 
            180                 185                 190         


Tyr Asp Arg Thr Phe Asp Asp Ser Asn Leu Ser Glu Ile Thr Val Asp 
        195                 200                 205             


Ala Ser Ser Ile Leu Thr Glu Lys Phe Ser Lys Ser Arg Arg Leu Glu 
    210                 215                 220                 


Asn Leu Ile Lys His Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly 
225                 230                 235                 240 


Asn Leu Val Ala Leu Ala Leu Gly Leu Gln Pro Asn Phe Lys Thr Ser 
                245                 250                 255     


Phe Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr 
            260                 265                 270         


Glu Glu Asp Leu Glu Glu Leu Ile Gly Lys Ile Gly Asp Glu Tyr Ala 
        275                 280                 285             


Asp Leu Phe Thr Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Ala Asp Asn Thr Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Lys Arg Tyr Asn Glu His Gln Val Asp Leu Lys Lys Leu 
                325                 330                 335     


Lys Glu Phe Ile Lys Asn Asn Ala Ser Asp Lys Tyr Asp Glu Ile Phe 
            340                 345                 350         


Asn Asp Lys Asp Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val 
        355                 360                 365             


Lys Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Thr Thr Leu Ser Lys Ile 
    370                 375                 380                 


Asp Gly Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Ala 
            420                 425                 430         


Phe Leu Lys Glu Asn Gln Ala Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Asn Ser Arg Phe Ala 
    450                 455                 460                 


Trp Ala Glu Tyr His Ser Asp Glu Lys Ile Thr Pro Trp Asn Phe Asp 
465                 470                 475                 480 


Glu Ile Ile Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met 
                485                 490                 495     


Thr Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Val Tyr Glu Thr Tyr Thr Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Tyr Val Asn Glu Gln Gly Lys Ser Asn Phe Phe Asp Ala Asn Met 
    530                 535                 540                 


Lys Gln Glu Ile Phe Glu His Val Phe Lys Glu Asn Arg Lys Val Thr 
545                 550                 555                 560 


Lys Asp Lys Phe Leu Asn Tyr Leu Asn Lys Glu Phe Pro Glu Tyr Arg 
                565                 570                 575     


Ile Gln Asp Leu Ile Gly Leu Asp Lys Glu Asn Lys Ser Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Ser Phe 
        595                 600                 605             


Leu Asp Asp Lys Thr Asn Glu Thr Ile Ile Glu Asp Ile Ile Gln Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Asp Met Ile Arg Gln Arg Leu Gln Lys 
625                 630                 635                 640 


Tyr Ser Asp Ile Phe Thr Pro Gln Gln Leu Lys Lys Leu Glu Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asn Lys Glu Asn Gly Lys Ser Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Tyr Ala Asn Arg Asn Phe Met Gln Leu Ile Ser Asp Asp Thr Leu 
    690                 695                 700                 


Pro Phe Lys Gln Ile Ile Lys Asp Ala Gln Ile Ile Gly Asp Ile Asp 
705                 710                 715                 720 


Asp Val Thr Ser Val Val Arg Glu Leu Pro Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly His Asn Pro Asp Asn Ile Val Ile Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Asn Arg Gly Arg Asn Gln Ser Gln Gln Arg Leu Lys Lys 
    770                 775                 780                 


Leu Gln Asp Ser Leu Lys Glu Leu Gly Ser Asn Ile Leu Asn Glu Glu 
785                 790                 795                 800 


Lys Pro Ser Tyr Ile Glu Gly Lys Val Glu Asn Asn His Leu Gln Asp 
                805                 810                 815     


Asp Arg Leu Phe Leu Tyr Tyr Ile Gln Asn Gly Lys Asp Met Tyr Thr 
            820                 825                 830         


Gly Asp Glu Leu Asp Ile Asp His Leu Ser Asp Tyr Asp Ile Asp His 
        835                 840                 845             


Ile Ile Pro Gln Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val 
    850                 855                 860                 


Leu Thr Ser Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser 
865                 870                 875                 880 


Leu Asp Ile Val His Asp Arg Lys Ala Asp Trp Ile Arg Leu Tyr Lys 
                885                 890                 895     


Ser Gly Leu Ile Ser Lys Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu 
            900                 905                 910         


Arg Gly Gly Leu Thr Glu Asn Asp Lys Ala Gly Phe Ile Lys Arg Gln 
        915                 920                 925             


Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp 
    930                 935                 940                 


Ser Arg Phe Asn Thr Glu Arg Asp Glu Asn Asp Lys Val Ile Arg Asn 
945                 950                 955                 960 


Val Lys Val Ile Thr Leu Lys Ser Asn Leu Val Ser Gln Phe Arg Lys 
                965                 970                 975     


Asp Phe Lys Phe Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His Ala 
            980                 985                 990         


His Asp Ala Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Leu Lys Lys 
        995                 1000                 1005             


Tyr Pro  Lys Leu Ala Pro Glu  Phe Val Tyr Gly Glu  Tyr Lys Lys 
    1010                 1015                 1020             


Tyr Asp  Ile Arg Lys Phe Ile  Thr Ser Ser Gly Asp  Lys Ala Thr 
    1025                 1030                 1035             


Ala Lys  Tyr Phe Phe Tyr Ser  Asn Leu Met Asn Phe  Phe Lys Arg 
    1040                 1045                 1050             


Val Ile  Arg Tyr Ser Asn Gly  Lys Val Val Val Arg  Pro Val Ile 
    1055                 1060                 1065             


Glu Cys  Ser Lys Asp Thr Gly  Glu Ile Ala Trp Asn  Lys Gln Thr 
    1070                 1075                 1080             


Asp Phe  Glu Lys Val Arg Arg  Val Leu Ser Tyr Pro  Gln Val Asn 
    1085                 1090                 1095             


Ile Val  Lys Lys Val Glu Thr  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1100                 1105                 1110             


Ser Ile  Leu Pro Lys Gly Asn  Ser Asp Lys Leu Ile  Pro Arg Lys 
    1115                 1120                 1125             


Thr Lys  Lys Phe Arg Trp Asp  Thr Pro Lys Tyr Gly  Gly Phe Asp 
    1130                 1135                 1140             


Ser Pro  Asn Ile Ala Tyr Ser  Val Phe Val Ile Ala  Asp Val Glu 
    1145                 1150                 1155             


Lys Gly  Lys Ala Lys Lys Leu  Lys Thr Val Lys Glu  Leu Val Gly 
    1160                 1165                 1170             


Ile Ser  Ile Met Glu Arg Ser  Ser Phe Glu Glu Asn  Pro Val Val 
    1175                 1180                 1185             


Phe Leu  Glu Lys Lys Gly Tyr  Gln Asn Val Gln Glu  Asp Asn Leu 
    1190                 1195                 1200             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Phe Glu  Gly Gly Arg 
    1205                 1210                 1215             


Arg Arg  Leu Leu Ala Ser Ala  Ser Glu Leu Gln Lys  Gly Asn Glu 
    1220                 1225                 1230             


Val Val  Leu Ser Arg His Leu  Val Glu Leu Leu Tyr  His Ala His 
    1235                 1240                 1245             


Arg Val  Asn Ser Phe Asn Asn  Ser Glu His Leu Lys  Tyr Val Ser 
    1250                 1255                 1260             


Glu His  Lys Lys Glu Phe Gly  Glu Val Leu Ser Cys  Val Glu Asn 
    1265                 1270                 1275             


Phe Ala  Lys Ser Tyr Val Asp  Val Glu Lys Asn Leu  Gly Lys Ile 
    1280                 1285                 1290             


Arg Ala  Val Ala Asp Lys Ile  Asp Thr Phe Ser Ile  Glu Asp Ile 
    1295                 1300                 1305             


Ser Ile  Ser Phe Val Asn Leu  Leu Thr Leu Thr Ala  Leu Gly Ala 
    1310                 1315                 1320             


Pro Ala  Asp Phe Asn Phe Leu  Gly Glu Lys Ile Pro  Arg Lys Arg 
    1325                 1330                 1335             


Tyr Thr  Ser Thr Lys Glu Cys  Leu Asn Ala Thr Leu  Ile His Gln 
    1340                 1345                 1350             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Lys Leu 
    1355                 1360                 1365             


Gly Glu  Glu 
    1370     


<210> 460
<211> 1130
<212> PRT
<213> Streptococcus gallolyticus

<400> 460
Met Thr Asn Gly Lys Ile Leu Gly Leu Asp Ile Gly Ile Ala Ser Val 
1               5                   10                  15      


Gly Val Gly Ile Ile Glu Ala Lys Thr Gly Lys Val Val His Ala Asn 
            20                  25                  30          


Ser Arg Leu Phe Ser Ala Ala Asn Ala Glu Asn Asn Ala Glu Arg Arg 
        35                  40                  45              


Gly Phe Arg Gly Ser Arg Arg Leu Asn Arg Arg Lys Lys His Arg Val 
    50                  55                  60                  


Lys Arg Val Arg Asp Leu Phe Glu Lys Tyr Glu Ile Val Thr Asp Phe 
65                  70                  75                  80  


Arg Asn Leu Asn Leu Asn Pro Tyr Glu Leu Arg Val Lys Gly Leu Thr 
                85                  90                  95      


Glu Gln Leu Thr Asn Glu Glu Leu Phe Ala Ala Leu Arg Thr Ile Ser 
            100                 105                 110         


Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Glu Asp Asp Ser Thr 
        115                 120                 125             


Gly Ser Thr Asp Tyr Ala Lys Ser Ile Asp Glu Asn Arg Arg Leu Leu 
    130                 135                 140                 


Lys Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Leu Glu Lys Tyr 
145                 150                 155                 160 


Gly Gln Leu Arg Gly Asn Phe Thr Val Tyr Asp Glu Asn Gly Glu Ala 
                165                 170                 175     


His Arg Leu Ile Asn Val Phe Ser Thr Ser Asp Tyr Glu Lys Glu Ala 
            180                 185                 190         


Arg Lys Ile Leu Glu Thr Gln Ala Asp Tyr Asn Lys Lys Ile Thr Ala 
        195                 200                 205             


Glu Phe Ile Asp Asp Tyr Val Glu Ile Leu Thr Gln Lys Arg Lys Tyr 
    210                 215                 220                 


Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg Phe 
225                 230                 235                 240 


Arg Thr Asp Gly Thr Thr Leu Glu Asn Ile Phe Gly Ile Leu Ile Gly 
                245                 250                 255     


Lys Cys Ser Phe Tyr Pro Asp Glu Tyr Arg Ala Ser Lys Ala Ser Tyr 
            260                 265                 270         


Thr Ala Gln Glu Tyr Asn Phe Leu Asn Asp Leu Asn Asn Leu Lys Val 
        275                 280                 285             


Pro Thr Glu Thr Gly Lys Leu Ser Thr Glu Gln Lys Glu Ala Leu Val 
    290                 295                 300                 


Glu Phe Ala Lys Ser Thr Ala Thr Leu Gly Pro Ala Lys Leu Leu Lys 
305                 310                 315                 320 


Glu Ile Ala Lys Ile Leu Asp Cys Lys Val Asp Glu Ile Lys Gly Tyr 
                325                 330                 335     


Arg Glu Asp Asp Lys Gly Lys Pro Asp Leu His Thr Phe Glu Pro Tyr 
            340                 345                 350         


Arg Lys Leu Lys Phe Asn Leu Asp Ser Val Asn Ile Asp Asp Leu Ser 
        355                 360                 365             


Arg Glu Val Leu Asp Lys Leu Ala Asp Ile Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Glu Asp Ala Ile Arg His Asn Leu Pro Asn Gln Phe 
385                 390                 395                 400 


Thr Glu Gly Gln Ile Ser Glu Ile Ile Lys Val Arg Lys Ser Gln Ser 
                405                 410                 415     


Thr Ala Phe Asn Lys Gly Trp His Ser Phe Ser Ala Lys Leu Met Asn 
            420                 425                 430         


Glu Leu Ile Pro Glu Leu Tyr Ala Thr Ser Asp Glu Gln Met Thr Ile 
        435                 440                 445             


Leu Thr Arg Leu Glu Lys Phe Lys Val Asn Lys Lys Ser Ser Lys Asn 
    450                 455                 460                 


Thr Lys Thr Ile Asp Glu Lys Glu Val Thr Asp Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ala Lys Ser Val Arg Gln Thr Ile Lys Ile Ile Asn Ala Ala 
                485                 490                 495     


Val Lys Lys Tyr Gly Asp Phe Asp Lys Ile Val Ile Glu Met Pro Arg 
            500                 505                 510         


Asp Lys Asn Ala Asp Asp Glu Lys Lys Phe Ile Asp Lys Arg Asn Lys 
        515                 520                 525             


Glu Asn Lys Lys Glu Lys Asp Asp Ala Leu Lys Arg Ala Ala Tyr Leu 
    530                 535                 540                 


Tyr Asn Gly Thr Asp Lys Leu Pro Asp Glu Val Phe His Gly Asn Lys 
545                 550                 555                 560 


Gln Leu Glu Thr Lys Ile Arg Leu Trp Tyr Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Leu Tyr Ser Gly Lys Pro Ile Pro Ile Gln Glu Leu Val His Asn Ser 
            580                 585                 590         


Asn Asn Phe Glu Ile Asp His Ile Leu Pro Leu Ser Leu Ser Phe Asp 
        595                 600                 605             


Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ala Trp Thr Asn Gln Glu 
    610                 615                 620                 


Lys Gly Gln Lys Thr Pro Tyr Gln Val Ile Asp Ser Met Asp Ala Ala 
625                 630                 635                 640 


Trp Ser Phe Arg Glu Met Lys Asp Tyr Val Leu Lys Gln Lys Gly Leu 
                645                 650                 655     


Gly Lys Lys Lys Arg Asp Tyr Leu Leu Thr Thr Glu Asn Ile Asp Lys 
            660                 665                 670         


Ile Glu Val Lys Lys Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ser Arg Val Val Leu Asn Ser Leu Gln Ser Ala Leu Arg Glu 
    690                 695                 700                 


Leu Gly Lys Asp Thr Lys Ile Ser Val Ile Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg Arg Lys Trp Lys Ile Asp Lys Ser Arg Glu Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Lys 
            740                 745                 750         


Leu Trp Glu Lys Gln Asp Asn Pro Met Phe Val Asp Tyr Gly Asn Asn 
        755                 760                 765             


Gln Val Val Asp Lys Gln Thr Gly Glu Ile Leu Ser Val Ser Asp Asp 
    770                 775                 780                 


Glu Tyr Lys Glu Leu Val Phe Gln Pro Pro Tyr Gln Gly Phe Val Asn 
785                 790                 795                 800 


Met Ile Ser Ser Lys Gly Phe Glu Asp Glu Ile Leu Phe Ser Tyr Gln 
                805                 810                 815     


Val Asp Ser Lys Tyr Asn Arg Lys Val Ser Asp Ala Thr Ile Tyr Ser 
            820                 825                 830         


Thr Arg Lys Ala Lys Ile Gly Lys Asp Lys Lys Glu Glu Thr Tyr Val 
        835                 840                 845             


Leu Gly Lys Ile Lys Asp Ile Tyr Ser Gln Asn Gly Phe Asp Thr Phe 
    850                 855                 860                 


Ile Lys Lys Tyr Asn Lys Asp Lys Thr Gln Phe Leu Met Tyr Gln Lys 
865                 870                 875                 880 


Asp Pro Leu Thr Trp Glu Asn Val Ile Glu Val Ile Leu Arg Asp Tyr 
                885                 890                 895     


Pro Thr Thr Lys Lys Ser Glu Asp Gly Lys Asn Asp Val Lys Cys Asn 
            900                 905                 910         


Pro Phe Glu Glu Tyr Arg Arg Glu Asn Gly Leu Val Cys Lys Tyr Ser 
        915                 920                 925             


Lys Lys Gly Lys Gly Thr Pro Ile Lys Ser Leu Lys Tyr Tyr Asp Lys 
    930                 935                 940                 


Lys Leu Gly Asn Cys Ile Asp Ile Thr Pro Glu Gly Ser Lys Asn Glu 
945                 950                 955                 960 


Val Val Leu Gln Ser Leu Asn Pro Trp Arg Ala Asp Val Tyr Phe Asn 
                965                 970                 975     


Pro Glu Thr Leu Lys Tyr Glu Leu Leu Gly Leu Lys Tyr Ser Asp Leu 
            980                 985                 990         


Ser Phe Glu Lys Gly Thr Gly Lys  Tyr His Ile Ser Gln  Glu Lys Tyr 
        995                 1000                 1005             


Asp Val  Ile Lys Glu Lys Glu  Gly Ile Gly Lys Lys  Ser Glu Phe 
    1010                 1015                 1020             


Lys Phe  Thr Leu Tyr Arg Asn  Asp Leu Ile Leu Ile  Lys Asp Thr 
    1025                 1030                 1035             


Ala Ser  Gly Glu Gln Glu Ile  Tyr Arg Phe Leu Ser  Arg Thr Met 
    1040                 1045                 1050             


Pro Asn  Val Lys His Tyr Ala  Glu Leu Lys Pro Tyr  Asp Lys Glu 
    1055                 1060                 1065             


Lys Phe  Asp Asn Val Gln Glu  Leu Val Glu Ala Leu  Gly Glu Ala 
    1070                 1075                 1080             


Asp Lys  Val Gly Arg Cys Ile  Lys Gly Leu Asn Lys  Ser Asn Leu 
    1085                 1090                 1095             


Ser Ile  Tyr Lys Val Arg Thr  Asp Val Leu Gly Asn  Lys Tyr Phe 
    1100                 1105                 1110             


Val Lys  Lys Glu Gly Asp Lys  Pro Lys Leu Asp Phe  Lys Asn Asn 
    1115                 1120                 1125             


Lys Lys  
    1130 


<210> 461
<211> 1136
<212> PRT
<213> Streptococcus gordonii

<400> 461
Met Asn Gly Leu Val Leu Gly Leu Asp Ile Gly Ile Ala Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Glu Lys Asp Thr Gly Lys Ile Ile His Ala Ser Ser 
            20                  25                  30          


Arg Leu Phe Pro Ala Ala Thr Ala Asp Asn Asn Val Glu Arg Arg Ser 
        35                  40                  45              


Asn Arg Gln Gly Arg Arg Leu Asn Arg Arg Lys Lys His Arg Ser Val 
    50                  55                  60                  


Arg Leu Gln Asp Leu Phe Glu Gly Tyr Gly Leu Leu Thr Asp Phe Ser 
65                  70                  75                  80  


Lys Val Ser Met Asn Leu Asn Pro Tyr Gln Leu Arg Val Gln Gly Met 
                85                  90                  95      


Glu Asn Gln Leu Thr Asn Glu Glu Leu Phe Val Ala Leu Lys Asn Ile 
            100                 105                 110         


Val Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Glu Asp Gly 
        115                 120                 125             


Gly Thr Val Ser Ser Asp Tyr Gly Lys Ala Val Glu Glu Asn Arg Lys 
    130                 135                 140                 


Leu Leu Ala Glu Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Phe Glu 
145                 150                 155                 160 


Lys Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Glu Glu Asn Gly Glu 
                165                 170                 175     


Lys His Arg Leu Ile Asn Val Phe Ser Thr Ser Ala Tyr Arg Lys Glu 
            180                 185                 190         


Ala Glu Arg Ile Leu Arg Lys Gln Gln Glu Phe Asn Ser Lys Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Glu Asp Tyr Leu Ile Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Phe Arg Thr Asp Gly Thr Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Thr Glu Glu Tyr Arg Ala Ser Lys Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Glu Glu Gln Lys Lys Leu Ile 
    290                 295                 300                 


Ile Glu Tyr Ala Lys Ser Ala Lys Thr Leu Gly Ala Ser Thr Leu Leu 
305                 310                 315                 320 


Lys Tyr Ile Ala Lys Met Ile Asp Ala Ser Val Asp Gln Ile Arg Gly 
                325                 330                 335     


Tyr Arg Val Asp Val Asn Asn Lys Pro Glu Met His Thr Phe Glu Val 
            340                 345                 350         


Tyr Arg Lys Met Gln Ser Leu Glu Thr Ile Lys Val Glu Glu Leu Pro 
        355                 360                 365             


Arg Lys Val Leu Asp Glu Leu Ala His Ile Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Glu Glu Ala Ile Asn Ser Lys Leu Lys Asp Ile Phe 
385                 390                 395                 400 


Asn Arg Asp Gln Val Leu Glu Leu Val Gln Phe Arg Lys Asn Asn Ser 
                405                 410                 415     


Ser Leu Phe Ser Lys Gly Trp His Asn Phe Ser Ile Lys Leu Met Met 
            420                 425                 430         


Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr Ile 
        435                 440                 445             


Leu Thr Arg Leu Gly Lys Gln Arg Ser Lys Glu Thr Ser Lys Arg Thr 
    450                 455                 460                 


Lys Tyr Ile Asp Glu Lys Glu Leu Thr Glu Glu Ile Tyr Asn Pro Val 
465                 470                 475                 480 


Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Ile Asn Glu Ala Thr 
                485                 490                 495     


Lys Lys Tyr Gly Ile Phe Asp Asn Ile Val Ile Glu Met Ala Arg Glu 
            500                 505                 510         


Asn Asn Glu Glu Asp Ala Lys Lys Asp Tyr Ile Lys Arg Gln Lys Ala 
        515                 520                 525             


Asn Gln Asp Glu Lys Asn Ala Ala Met Glu Lys Ala Ala Phe Gln Tyr 
    530                 535                 540                 


Asn Gly Lys Lys Glu Leu Pro Asp Asn Ile Phe His Gly His Lys Glu 
545                 550                 555                 560 


Leu Thr Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Lys Cys Leu 
                565                 570                 575     


Tyr Thr Gly Lys Asn Ile Pro Ile Ser Asp Leu Ile His Asn Gln Tyr 
            580                 585                 590         


Lys Tyr Glu Ile Asp His Ile Leu Pro Leu Ser Leu Ser Phe Asp Asp 
        595                 600                 605             


Ser Leu Ser Asn Lys Val Leu Val Leu Ala Thr Ala Asn Gln Glu Lys 
    610                 615                 620                 


Gly Gln Arg Thr Pro Phe Gln Ala Leu Asp Ser Met Asp Asp Ala Trp 
625                 630                 635                 640 


Ser Tyr Arg Glu Phe Lys Ser Tyr Val Lys Asp Ser Lys Leu Leu Ser 
                645                 650                 655     


Asn Lys Lys Lys Asp Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys Ile 
            660                 665                 670         


Glu Val Lys Gln Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg Tyr 
        675                 680                 685             


Ser Ser Arg Val Val Leu Asn Ala Leu Gln Asp Phe Tyr Lys Ser His 
    690                 695                 700                 


Gln Leu Asp Thr Thr Ile Ser Val Val Arg Gly Gln Phe Thr Ser Gln 
705                 710                 715                 720 


Leu Arg Arg Lys Trp Gly Ile Glu Lys Ser Arg Glu Thr Tyr His His 
                725                 730                 735     


His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Arg Leu 
            740                 745                 750         


Trp Lys Lys His Ser Asn Pro Leu Ile Ala Tyr Lys Glu Gly Gln Phe 
        755                 760                 765             


Val Asp Ser Glu Thr Gly Glu Ile Val Ser Leu Ser Asp Glu Glu Tyr 
    770                 775                 780                 


Lys Glu Leu Val Phe Lys Ala Pro Tyr Asp His Phe Val Asp Thr Leu 
785                 790                 795                 800 


Arg Ser Lys Lys Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln Val Asp 
                805                 810                 815     


Ser Lys Tyr Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg 
            820                 825                 830         


Lys Ala Lys Leu Asp Lys Glu Lys Lys Glu Tyr Thr Tyr Thr Leu Gly 
        835                 840                 845             


Lys Ile Lys Asp Ile Tyr Ala Leu Gly Thr Lys Thr Pro Ser Lys Thr 
    850                 855                 860                 


Gly Phe Tyr Lys Phe Leu Asp Leu Tyr Lys Thr Asp Lys Ser Gln Phe 
865                 870                 875                 880 


Leu Met Tyr Gln Lys Asp Arg Lys Thr Trp Asp Glu Val Ile Glu Lys 
                885                 890                 895     


Ile Ile Glu Gln Tyr Arg Pro Phe Lys Glu Tyr Asp Lys Asn Gly Lys 
            900                 905                 910         


Glu Val Asp Phe Asn Pro Phe Glu Lys Tyr Arg Ile Gly Asn Gly Pro 
        915                 920                 925             


Ile Arg Lys Tyr Ser Lys Lys Gly Asn Gly Pro Glu Ile Lys Ser Leu 
    930                 935                 940                 


Lys Tyr Tyr Asp Ile Leu Leu Gly Lys His Lys Asn Ile Thr Pro Asp 
945                 950                 955                 960 


Gly Ser Arg Asn Thr Val Ala Leu Leu Ser Leu Asn Pro Trp Arg Thr 
                965                 970                 975     


Asp Val Tyr Tyr Asn Ser Glu Thr Lys Lys Tyr Glu Phe Leu Gly Leu 
            980                 985                 990         


Lys Tyr Ala Asp Leu Cys Phe Glu  Glu Gly Gly Ala Tyr  Gly Ile Ser 
        995                 1000                 1005             


Glu Val  Lys Tyr Lys Lys Ile  Arg Glu Lys Glu Gly  Ile Gly Lys 
    1010                 1015                 1020             


Asn Ser  Glu Phe Lys Phe Thr  Leu Tyr Lys Asn Asp  Leu Ile Leu 
    1025                 1030                 1035             


Ile Lys  Asp Thr Glu Thr Asn  Cys Gln Gln Phe Phe  Arg Phe Trp 
    1040                 1045                 1050             


Ser Arg  Thr Gly Lys Asp Asn  Pro Lys Ser Phe Glu  Lys His Lys 
    1055                 1060                 1065             


Ile Glu  Leu Lys Pro Tyr Glu  Lys Ala Lys Phe Glu  Lys Gly Glu 
    1070                 1075                 1080             


Glu Leu  Lys Val Leu Gly Lys  Val Pro Pro Ser Ser  Asn Gln Phe 
    1085                 1090                 1095             


Gln Lys  Asn Met Gln Ile Glu  Asn Leu Ser Ile Tyr  Lys Val Lys 
    1100                 1105                 1110             


Thr Asp  Ile Leu Gly Asn Lys  His Phe Ile Lys Lys  Glu Gly Asp 
    1115                 1120                 1125             


Glu Pro  Lys Leu Lys Phe Lys  Lys 
    1130                 1135     


<210> 462
<211> 1129
<212> PRT
<213> Streptococcus infantarius


<220>
<223> Streptococcus infantarius subsp. infantarius ATCC BAA-102

<400> 462
Met Ser Asn Gly Lys Ile Leu Gly Leu Asp Ile Gly Val Ala Ser Val 
1               5                   10                  15      


Gly Val Gly Ile Ile Asp Ser Lys Thr Gly Asn Val Ile His Ala Asn 
            20                  25                  30          


Ser Arg Leu Phe Ser Ala Ala Asn Ala Glu Asn Asn Ala Glu Arg Arg 
        35                  40                  45              


Gly Phe Arg Gly Ala Arg Arg Leu Thr Arg Arg Lys Lys His Arg Val 
    50                  55                  60                  


Lys Arg Val Arg Asp Leu Phe Glu Lys Tyr Asp Ile Ser Thr Asp Phe 
65                  70                  75                  80  


Arg Asn Leu Asn Leu Asn Pro Tyr Glu Leu Arg Val Lys Gly Leu Thr 
                85                  90                  95      


Glu Gln Leu Thr Asn Glu Glu Leu Phe Ala Ala Leu Arg Thr Ile Ala 
            100                 105                 110         


Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Glu Asp Asp Ser Thr 
        115                 120                 125             


Gly Ser Ser Asp Tyr Ala Lys Ser Ile Asp Glu Asn Arg Arg Leu Leu 
    130                 135                 140                 


Lys Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Leu Glu Lys Tyr 
145                 150                 155                 160 


Gly Gln Leu Arg Gly Asn Phe Thr Val Tyr Asp Glu Asn Gly Glu Ala 
                165                 170                 175     


His Arg Leu Ile Asn Val Phe Ser Thr Ser Asp Tyr Lys Asn Glu Ala 
            180                 185                 190         


Arg Lys Ile Leu Glu Thr Gln Ser Asn Tyr Asn Lys Gln Ile Thr Asp 
        195                 200                 205             


Glu Phe Ile Glu Asp Tyr Ile Glu Ile Leu Thr Gln Lys Arg Lys Tyr 
    210                 215                 220                 


Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg Phe 
225                 230                 235                 240 


Arg Thr Asp Gly Thr Thr Leu Glu Asn Ile Phe Gly Ile Leu Ile Gly 
                245                 250                 255     


Lys Cys Ser Phe Tyr Pro Glu Glu Tyr Arg Ala Ser Lys Ala Ser Tyr 
            260                 265                 270         


Thr Ala Gln Glu Phe Asn Phe Leu Asn Asp Leu Asn Asn Leu Lys Val 
        275                 280                 285             


Pro Thr Glu Thr Gly Lys Leu Ser Thr Glu Gln Lys Glu Tyr Leu Val 
    290                 295                 300                 


Asp Phe Ala Lys Lys Ser Lys Ala Leu Gly Ala Ser Lys Leu Leu Lys 
305                 310                 315                 320 


Glu Ile Ala Lys Ile Val Asp Cys Ser Val Asp Asp Ile Lys Gly Tyr 
                325                 330                 335     


Arg Val Asp Asn Lys Asp Lys Pro Asp Leu His Thr Phe Glu Pro Tyr 
            340                 345                 350         


Arg Lys Leu Lys Phe Asn Leu Ser Ser Ile Asp Ile Asp Glu Leu Ser 
        355                 360                 365             


Arg Glu Thr Leu Asp Lys Leu Ala Asp Ile Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Glu Asp Ala Ile Lys Arg Asn Leu Pro Ser Gln Phe 
385                 390                 395                 400 


Thr Glu Glu Gln Ile Ser Glu Ile Val Gln Ile Arg Lys Asn Gln Ser 
                405                 410                 415     


Ser Ala Phe Asn Lys Gly Trp His Ser Phe Ser Ala Lys Leu Met Asn 
            420                 425                 430         


Glu Leu Ile Pro Glu Leu Tyr Val Thr Ser Glu Glu Gln Met Thr Ile 
        435                 440                 445             


Leu Thr Arg Leu Glu Lys Phe Lys Val Asn Lys Lys Ser Ser Lys Asn 
    450                 455                 460                 


Thr Lys Thr Ile Asp Glu Lys Glu Ile Thr Asp Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ala Lys Ser Val Arg Gln Thr Ile Lys Ile Ile Asn Ala Ala 
                485                 490                 495     


Val Lys Lys Tyr Gly Asp Phe Asp Lys Ile Val Ile Glu Met Pro Arg 
            500                 505                 510         


Asp Lys Asn Ala Glu Asp Glu Lys Lys Phe Ile Asp Lys Lys Gln Lys 
        515                 520                 525             


Glu Asn Lys Lys Glu Lys Asp Asp Ser Leu Lys Arg Ala Ala Phe Leu 
    530                 535                 540                 


Tyr Asn Gly Thr Asp Asn Leu Pro Asp Gly Val Phe His Gly Asn Lys 
545                 550                 555                 560 


Glu Leu Lys Thr Lys Ile Arg Leu Trp Tyr Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Leu Tyr Ser Gly Lys Leu Ile Ser Ile His Asp Leu Val His Asn Ser 
            580                 585                 590         


Asn Lys Phe Glu Ile Asp His Ile Leu Pro Leu Ser Leu Ser Phe Asp 
        595                 600                 605             


Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ala Trp Thr Asn Gln Glu 
    610                 615                 620                 


Lys Gly Gln Lys Thr Pro Tyr Gln Val Ile Asp Ser Met Asp Thr Ala 
625                 630                 635                 640 


Trp Ser Phe Arg Glu Met Lys Asp Tyr Val Leu Lys Gln Lys Gly Leu 
                645                 650                 655     


Gly Lys Lys Lys Cys Glu Tyr Leu Leu Thr Thr Glu Asn Ile Asp Lys 
            660                 665                 670         


Ile Glu Val Lys Lys Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ser Arg Val Val Leu Asn Ser Leu Gln Thr Ala Leu Lys Glu 
    690                 695                 700                 


Leu Gly Lys Asp Thr Lys Val Ser Val Val Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg Arg Lys Trp Asn Ile Asp Lys Ser Arg Glu Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Lys 
            740                 745                 750         


Leu Trp Gln Lys Gln Glu Asn Pro Met Phe Glu Ser Tyr Gly Glu Asn 
        755                 760                 765             


Gln Val Val Asn Lys Glu Thr Gly Glu Ile Leu Ser Ile Ser Asp Asp 
    770                 775                 780                 


Lys Tyr Lys Glu Leu Val Phe Gln Pro Pro Tyr Gln Gly Phe Val Asn 
785                 790                 795                 800 


Thr Ile Ser Ser Lys Gly Phe Glu Asp Glu Ile Leu Phe Ser Tyr Gln 
                805                 810                 815     


Val Asp Ser Lys Phe Asn Arg Lys Val Ser Asp Ala Thr Ile Tyr Ser 
            820                 825                 830         


Thr Arg Lys Ala Lys Leu Gly Lys Asp Lys Lys Asp Glu Thr Tyr Val 
        835                 840                 845             


Leu Gly Lys Ile Lys Asp Ile Tyr Ser Gln Asp Gly Phe Asp Thr Phe 
    850                 855                 860                 


Ile Lys Arg Tyr Lys Lys Asp Lys Thr Gln Phe Leu Met Tyr Gln Lys 
865                 870                 875                 880 


Asp Pro Leu Thr Trp Glu Asn Val Ile Glu Val Ile Leu Arg Asp Tyr 
                885                 890                 895     


Pro Ser Glu Lys Leu Ser Glu Asp Gly Lys Lys Thr Val Lys Cys Asn 
            900                 905                 910         


Pro Phe Glu Glu Tyr Arg Arg Glu Asn Gly Leu Ile Cys Lys Tyr Ser 
        915                 920                 925             


Lys Lys Gly Asn Gly Thr Pro Ile Lys Ser Leu Lys Tyr Tyr Asp Lys 
    930                 935                 940                 


Lys Leu Gly Asn Cys Ile Asp Ile Thr Pro Glu Lys Ser Lys Asn Arg 
945                 950                 955                 960 


Val Val Leu Arg Gln Ile Ser Pro Trp Arg Ala Asp Ile Tyr Phe Asn 
                965                 970                 975     


Leu Glu Thr Leu Lys Tyr Glu Leu Met Gly Leu Lys Tyr Ser Asp Leu 
            980                 985                 990         


Ser Phe Glu Lys Gly Thr Gly Lys  Tyr His Ile Ser Gln  Glu Lys Tyr 
        995                 1000                 1005             


Asp Ala  Ile Arg Glu Lys Glu  Gly Ile Gly Lys Lys  Ser Glu Phe 
    1010                 1015                 1020             


Lys Phe  Thr Leu Tyr Arg Asn  Asp Leu Ile Leu Ile  Lys Asp Thr 
    1025                 1030                 1035             


Leu Asn  Asn Cys Glu Arg Met  Leu Arg Phe Gly Ser  Lys Asn Asp 
    1040                 1045                 1050             


Thr Ser  Lys His Tyr Val Glu  Leu Lys Pro Leu Glu  Lys Gly Thr 
    1055                 1060                 1065             


Phe Asp  Ser Glu Glu Glu Ile  Leu Pro Val Leu Gly  Lys Val Ala 
    1070                 1075                 1080             


Lys Ser  Gly Gln Phe Ile Lys  Gly Leu Asn Lys Pro  Asn Ile Ser 
    1085                 1090                 1095             


Ile Tyr  Lys Val Arg Thr Asp  Val Leu Gly Asn Lys  Phe Phe Ile 
    1100                 1105                 1110             


Lys Lys  Glu Gly Asp Lys Pro  Lys Leu Asp Phe Lys  Asn Asn Asn 
    1115                 1120                 1125             


Lys 
    


<210> 463
<211> 1375
<212> PRT
<213> Streptococcus infantarius

<400> 463
Met Glu Lys Ser Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Lys Tyr Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Val Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Lys Glu Met Thr Lys Val Asp Glu Ser 
                85                  90                  95      


Phe Phe Gln Arg Leu Glu Glu Ser Phe Leu Thr Asp Asp Asp Lys Thr 
            100                 105                 110         


Phe Asp Ser His Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala Tyr 
        115                 120                 125             


His Gln Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Tyr Leu Ala Asp 
    130                 135                 140                 


Ser Gln Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Lys Leu Phe Asn Val Phe Val Glu Thr Tyr 
            180                 185                 190         


Asp Lys Ile Val Asp Glu Ser His Leu Ser Glu Ile Glu Val Asp Ala 
        195                 200                 205             


Ser Ser Ile Leu Thr Glu Lys Val Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Lys Gln Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ala Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Val Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ile Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Asp Asp Asn Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Val Glu His His Glu Asp Leu Glu Lys Leu Lys 
                325                 330                 335     


Glu Phe Ile Lys Ile Asn Lys Leu Lys Leu Tyr His Asp Ile Phe Lys 
            340                 345                 350         


Asp Lys Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Asn Gly Val Lys 
        355                 360                 365             


Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Thr Ile Leu Thr Lys Ile Asp 
    370                 375                 380                 


Asp Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Asp Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ser Ile Leu Arg Arg Gln Gly Asp Tyr Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Ala Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Asp Ser Arg Phe Ala Trp 
    450                 455                 460                 


Ala Asn Tyr His Ser Asp Glu Pro Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Val Val Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met Thr 
                485                 490                 495     


Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


His Val Tyr Glu Thr Phe Thr Val Tyr Asn Glu Leu Thr Lys Ile Lys 
        515                 520                 525             


Tyr Val Asn Glu Gln Gly Glu Ser Phe Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys Val Thr Lys 
545                 550                 555                 560 


Ala Lys Leu Leu Ser Tyr Leu Asn Asn Glu Phe Glu Glu Phe Arg Ile 
                565                 570                 575     


Asn Asp Leu Ile Gly Leu Asp Lys Asp Ser Lys Ser Phe Asn Ala Ser 
            580                 585                 590         


Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Ser Phe Leu 
        595                 600                 605             


Asp Asp Lys Thr Asn Gly Gln Ile Ile Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Asp Met Ile His Glu Arg Leu Gln Lys Tyr 
625                 630                 635                 640 


Ser Asp Phe Phe Thr Ser Gln Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Asn Asn Lys Thr Ile Leu Asp Phe Leu Ile Asp Asp Gly 
        675                 680                 685             


His Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Glu Ser Leu Ser 
    690                 695                 700                 


Phe Lys Thr Ile Ile Gln Glu Ala Gln Val Val Gly Asp Val Asp Asp 
705                 710                 715                 720 


Ile Glu Ala Val Val His Asp Leu Pro Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly Asp Asn Pro Asp Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gly Tyr Gly Arg Asn Lys Ser Asn Gln Arg Leu Lys Arg Leu 
    770                 775                 780                 


Gln Asp Ser Leu Lys Glu Phe Gly Ser Asp Ile Leu Ser Lys Lys Lys 
785                 790                 795                 800 


Pro Ser Tyr Val Asp Ser Lys Val Glu Asn Ser His Leu Gln Asn Asp 
                805                 810                 815     


Arg Leu Phe Leu Tyr Tyr Ile Gln Asn Gly Lys Asp Met Tyr Thr Gly 
            820                 825                 830         


Glu Glu Leu Asp Ile Asp Arg Leu Ser Asp Tyr Asp Ile Asp His Ile 
        835                 840                 845             


Ile Pro Gln Ala Phe Ile Lys Asp Asn Ser Ile Asp Asn Lys Val Leu 
    850                 855                 860                 


Thr Ser Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Ile 
865                 870                 875                 880 


Glu Ile Val Arg Asn Arg Arg Ser Tyr Trp Tyr Lys Leu Tyr Lys Ser 
                885                 890                 895     


Gly Leu Ile Ser Lys Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 
            900                 905                 910         


Gly Gly Leu Thr Glu Ala Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu 
        915                 920                 925             


Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ala 
    930                 935                 940                 


Arg Phe Asn Thr Lys Arg Asp Glu Asn Asp Lys Val Ile Arg Asp Val 
945                 950                 955                 960 


Lys Val Ile Thr Leu Lys Ser Asn Leu Val Ser Gln Phe Arg Lys Glu 
                965                 970                 975     


Phe Lys Phe Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His 
            980                 985                 990         


Asp Ala Tyr Leu Asn Ala Val Val  Gly Thr Ala Leu Leu  Lys Lys Tyr 
        995                 1000                 1005             


Pro Lys  Leu Thr Pro Glu Phe  Val Tyr Gly Glu Tyr  Lys Lys Tyr 
    1010                 1015                 1020             


Asp Val  Arg Lys Leu Ile Ala  Lys Ser Ser Asp Asp  Tyr Ser Glu 
    1025                 1030                 1035             


Met Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe Tyr Ser  Asn Leu Met 
    1040                 1045                 1050             


Asn Phe  Phe Lys Thr Glu Val  Lys Tyr Ala Asp Gly  Arg Val Phe 
    1055                 1060                 1065             


Glu Arg  Pro Asp Ile Glu Thr  Asn Ala Asp Gly Glu  Val Val Trp 
    1070                 1075                 1080             


Asn Lys  Gln Lys Asp Phe Asp  Ile Val Arg Lys Val  Leu Ser Tyr 
    1085                 1090                 1095             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Ala Gln  Thr Gly Gly 
    1100                 1105                 1110             


Phe Ser  Lys Glu Ser Ile Leu  Ser Lys Gly Asp Ser  Asp Lys Leu 
    1115                 1120                 1125             


Ile Pro  Arg Lys Thr Lys Lys  Val Tyr Trp Asn Thr  Lys Lys Tyr 
    1130                 1135                 1140             


Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr Ser Val  Leu Val Val 
    1145                 1150                 1155             


Ala Asp  Ile Glu Lys Gly Lys  Ala Lys Lys Leu Lys  Thr Val Lys 
    1160                 1165                 1170             


Glu Leu  Val Gly Ile Ser Ile  Met Glu Arg Ser Phe  Phe Glu Glu 
    1175                 1180                 1185             


Asn Pro  Val Ser Phe Leu Glu  Lys Lys Gly Tyr His  Asn Val Gln 
    1190                 1195                 1200             


Glu Asp  Lys Leu Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Phe 
    1205                 1210                 1215             


Glu Gly  Gly Arg Arg Arg Leu  Leu Ala Ser Ala Thr  Glu Leu Gln 
    1220                 1225                 1230             


Lys Gly  Asn Glu Val Met Leu  Pro Ala His Leu Val  Glu Leu Leu 
    1235                 1240                 1245             


Tyr His  Ala His Arg Ile Asp  Ser Phe Asn Ser Thr  Glu His Leu 
    1250                 1255                 1260             


Lys Tyr  Val Ser Glu His Lys  Lys Glu Phe Glu Lys  Val Leu Ser 
    1265                 1270                 1275             


Cys Val  Glu Asn Phe Ser Asn  Leu Tyr Val Asp Val  Glu Lys Asn 
    1280                 1285                 1290             


Leu Ser  Lys Val Arg Ala Ala  Ala Glu Ser Met Thr  Asn Phe Ser 
    1295                 1300                 1305             


Leu Glu  Glu Ile Ser Ala Ser  Phe Ile Asn Leu Leu  Thr Leu Thr 
    1310                 1315                 1320             


Ala Leu  Gly Ala Pro Ala Asp  Phe Asn Phe Leu Gly  Glu Lys Ile 
    1325                 1330                 1335             


Pro Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Cys Leu  Ser Ala Thr 
    1340                 1345                 1350             


Leu Ile  His Gln Ser Val Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1355                 1360                 1365             


Leu Ser  Lys Leu Gly Glu Glu  
    1370                 1375 


<210> 464
<211> 1368
<212> PRT
<213> Streptococcus iniae


<220>
<223> Streptococcus iniae 9117

<400> 464
Met Arg Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Met 
            20                  25                  30          


Arg Ile Gln Gly Thr Thr Asp Arg Thr Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Asn Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Thr Arg Arg Arg Tyr Thr Arg Arg Lys Tyr Arg Ile Lys 
65                  70                  75                  80  


Glu Leu Gln Lys Ile Phe Ser Ser Glu Met Asn Glu Leu Asp Ile Ala 
                85                  90                  95      


Phe Phe Pro Arg Leu Ser Glu Ser Phe Leu Val Ser Asp Asp Lys Glu 
            100                 105                 110         


Phe Glu Asn His Pro Ile Phe Gly Asn Leu Lys Asp Glu Ile Thr Tyr 
        115                 120                 125             


His Asn Asp Tyr Pro Thr Ile Tyr His Leu Arg Gln Thr Leu Ala Asp 
    130                 135                 140                 


Ser Asp Gln Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asn Leu Asp Ser 
                165                 170                 175     


Glu Asn Thr Asp Val His Val Leu Phe Leu Asn Leu Val Asn Ile Tyr 
            180                 185                 190         


Asn Asn Leu Phe Glu Glu Asp Ile Val Glu Thr Ala Ser Ile Asp Ala 
        195                 200                 205             


Glu Lys Ile Leu Thr Ser Lys Thr Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Glu Ile Pro Asn Gln Lys Arg Asn Met Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Val Ser Leu Ala Leu Gly Leu Thr Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Glu Leu Leu Glu Asp Ala Lys Leu Gln Ile Ser Lys Asp Ser Tyr Glu 
            260                 265                 270         


Glu Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ile Ala Ala Lys Lys Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Ile Thr Val Lys Gly Ala Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Gln Arg Tyr Glu Glu His Gln Gln Asp Leu Ala Leu Leu Lys 
                325                 330                 335     


Asn Leu Val Lys Lys Gln Ile Pro Glu Lys Tyr Lys Glu Ile Phe Asp 
            340                 345                 350         


Asn Lys Glu Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Tyr Ile Lys Pro Ile Leu Leu Lys Leu Asp 
    370                 375                 380                 


Gly Thr Glu Lys Leu Ile Ser Lys Leu Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Asn Glu Leu Lys Ala Ile Ile Arg Arg Gln Glu Lys Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Lys Lys Ile Glu Lys Leu Phe Thr Phe Lys Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Asn Gly Gln Ser Ser Phe Ala Trp 
    450                 455                 460                 


Leu Lys Arg Gln Ser Asn Glu Ser Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Gln Glu Ala Ser Ala Arg Ala Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Thr Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Pro Leu Tyr Glu Met Phe Met Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Gln Thr Glu Gly Met Lys Arg Pro Val Phe Leu Ser Ser Glu Asp 
    530                 535                 540                 


Lys Glu Glu Ile Val Asn Leu Leu Phe Lys Lys Glu Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Glu Tyr Phe Ser Lys Met Lys Cys Phe His 
                565                 570                 575     


Thr Val Thr Ile Leu Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Phe Lys Asp Lys Ala Phe Leu Asp 
        595                 600                 605             


Asp Glu Ala Asn Gln Asp Ile Leu Glu Glu Ile Val Trp Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Gln Ala Met Ile Glu Arg Arg Leu Val Lys Tyr Ala 
625                 630                 635                 640 


Asp Val Phe Glu Lys Ser Val Leu Lys Lys Leu Lys Lys Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Gln Lys Leu Ile Asn Gly Ile Lys Asp 
            660                 665                 670         


Lys Gln Thr Gly Lys Thr Ile Leu Gly Phe Leu Lys Asp Asp Gly Val 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Ser Ser Leu Asp Phe 
    690                 695                 700                 


Ala Lys Ile Ile Lys Asn Glu Gln Glu Lys Thr Ile Lys Asn Glu Ser 
705                 710                 715                 720 


Leu Glu Glu Thr Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Ile Val Lys Ile Met 
            740                 745                 750         


Gly Gln Asn Pro Asp Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Ser Thr Met Gln Gly Ile Lys Asn Ser Arg Gln Arg Leu Arg Lys Leu 
    770                 775                 780                 


Glu Glu Val His Lys Asn Thr Gly Ser Lys Ile Leu Lys Glu Tyr Asn 
785                 790                 795                 800 


Val Ser Asn Thr Gln Leu Gln Ser Asp Arg Leu Tyr Leu Tyr Leu Leu 
                805                 810                 815     


Gln Asp Gly Lys Asp Met Tyr Thr Gly Lys Glu Leu Asp Tyr Asp Asn 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ser Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Thr Val Leu Thr Thr Gln Ala Ser Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Asn Ile Glu Thr Val Asn Lys Met Lys 
865                 870                 875                 880 


Ser Phe Trp Tyr Lys Gln Leu Lys Ser Gly Ala Ile Ser Gln Arg Lys 
                885                 890                 895     


Phe Asp His Leu Thr Lys Ala Glu Arg Gly Ala Leu Ser Asp Phe Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Phe Asn Ser Asn Leu Thr 
    930                 935                 940                 


Glu Asp Ser Lys Ser Asn Arg Asn Val Lys Ile Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Met Val Ser Asp Phe Arg Lys Asp Phe Gly Phe Tyr Lys Leu Arg 
                965                 970                 975     


Glu Val Asn Asp Tyr His His Ala Gln Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Leu Lys Lys  Tyr Pro Lys Leu Glu  Ala Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys His  Tyr Asp Leu Ala Lys  Leu Met Ile 
    1010                 1015                 1020             


Gln Pro  Asp Ser Ser Leu Gly  Lys Ala Thr Thr Arg  Met Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Leu Met Asn Phe  Phe Lys Lys Glu Ile  Lys Leu Ala 
    1040                 1045                 1050             


Asp Asp  Thr Ile Phe Thr Arg  Pro Gln Ile Glu Val  Asn Thr Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Val Lys Asp Met  Gln Thr Ile 
    1070                 1075                 1080             


Arg Lys  Val Met Ser Tyr Pro  Gln Val Asn Ile Val  Met Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Trp Pro Lys 
    1100                 1105                 1110             


Gly Asp  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Ser  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Ile Ile Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Ile Ala  Lys Gly Lys Thr Gln  Lys Leu Lys 
    1145                 1150                 1155             


Thr Ile  Lys Glu Leu Val Gly  Ile Lys Ile Met Glu  Gln Asp Glu 
    1160                 1165                 1170             


Phe Glu  Lys Asp Pro Ile Ala  Phe Leu Glu Lys Lys  Gly Tyr Gln 
    1175                 1180                 1185             


Asp Ile  Gln Thr Ser Ser Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Leu Leu Ala  Ser Ala Lys 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Asn  Lys Tyr Val 
    1220                 1225                 1230             


Lys Phe  Leu Tyr Leu Ala Ser  His Tyr Thr Lys Phe  Thr Gly Lys 
    1235                 1240                 1245             


Glu Glu  Asp Arg Glu Lys Lys  Arg Ser Tyr Val Glu  Ser His Leu 
    1250                 1255                 1260             


Tyr Tyr  Phe Asp Glu Ile Met  Gln Ile Ile Val Glu  Tyr Ser Asn 
    1265                 1270                 1275             


Arg Tyr  Ile Leu Ala Asp Ser  Asn Leu Ile Lys Ile  Gln Asn Leu 
    1280                 1285                 1290             


Tyr Lys  Glu Lys Asp Asn Phe  Ser Ile Glu Glu Gln  Ala Ile Asn 
    1295                 1300                 1305             


Met Leu  Asn Leu Phe Thr Phe  Thr Asp Leu Gly Ala  Pro Ser Ala 
    1310                 1315                 1320             


Phe Lys  Phe Phe Asn Gly Asp  Ile Asp Arg Lys Arg  Tyr Ser Ser 
    1325                 1330                 1335             


Thr Asn  Glu Ile Ile Asn Ser  Thr Leu Ile Tyr Gln  Ser Pro Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Lys Leu  Gly Gly Lys 
    1355                 1360                 1365             


<210> 465
<211> 1338
<212> PRT
<213> Streptococcus macacae


<220>
<223> Streptococcus macacae NCTC 11558

<400> 465
Met Thr Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Gly Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Lys Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ala Lys Ala Asp Glu Ser 
                85                  90                  95      


Phe Phe Gln Arg Leu Asn Glu Ser Phe Leu Thr Asn Asp Asp Lys Glu 
            100                 105                 110         


Phe Asp Ser His Pro Ile Phe Gly Asn Lys Ala Glu Glu Glu Ala His 
        115                 120                 125             


His His Lys Phe Pro Thr Ile Phe His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ser Thr Glu Lys Ser Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Gln Leu Lys Ala 
                165                 170                 175     


Glu Asn Thr Asn Val Gln Thr Leu Phe Asp Asp Phe Val Glu Val Tyr 
            180                 185                 190         


Asp Lys Thr Val Glu Glu Ser His Leu Ser Glu Ile Ser Val Ser Ser 
        195                 200                 205             


Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile 
    210                 215                 220                 


Lys Tyr Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly Asn Leu Ile 
225                 230                 235                 240 


Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe Lys Leu 
                245                 250                 255     


Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu Glu Asp 
            260                 265                 270         


Leu Gly Glu Leu Leu Gly Lys Ile Gly Asp Asn Tyr Ala Asp Leu Phe 
        275                 280                 285             


Ile Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly Ile Leu 
    290                 295                 300                 


Thr Ile Asp Asp Asn Thr Thr Lys Ala Pro Leu Ser Ala Ser Met Ile 
305                 310                 315                 320 


Lys Arg Tyr Glu Glu His Gln Glu Asp Leu Ala Gln Leu Lys Lys Phe 
                325                 330                 335     


Ile Arg Gln Asn Leu Pro Asp Gln Tyr Ser Glu Val Phe Ser Asp Lys 
            340                 345                 350         


Thr Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn Gln Glu 
        355                 360                 365             


Ala Phe Tyr Lys Tyr Ile Lys Asn Met Leu Ser Lys Thr Glu Gly Ala 
    370                 375                 380                 


Asp Tyr Phe Leu Asp Lys Ile Asp Arg Glu Asp Phe Leu Arg Lys Gln 
385                 390                 395                 400 


Arg Thr Phe Asp Asn Gly Ser Val Pro His Gln Ile His Leu Gln Glu 
                405                 410                 415     


Met His Ala Ile Leu Arg Arg Gln Gly Glu Tyr Tyr Pro Phe Leu Lys 
            420                 425                 430         


Glu Asn Gln Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr 
        435                 440                 445             


Tyr Val Gly Pro Leu Ala Arg Lys Gly Ser Arg Phe Ala Trp Ala Glu 
    450                 455                 460                 


Tyr Lys Ala Asp Lys Lys Val Thr Pro Trp Asn Phe Asp Asp Ile Leu 
465                 470                 475                 480 


Asp Lys Glu Lys Ser Ala Glu Glu Phe Ile Thr Arg Met Thr Leu Asn 
                485                 490                 495     


Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser Leu Val 
            500                 505                 510         


Tyr Glu Thr Phe Asn Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val 
        515                 520                 525             


Asn Glu Gln Gly Lys Ala Ile Phe Phe Asp Ala Asn Met Lys Gln Glu 
    530                 535                 540                 


Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys Val Thr Lys Asp Lys 
545                 550                 555                 560 


Leu Leu Asn Tyr Leu Asn Lys Glu Phe Glu Glu Phe Arg Ile Val Asn 
                565                 570                 575     


Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ser Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Ser Phe Leu Asp Asp 
        595                 600                 605             


Lys Val Asn Glu Lys Ile Ile Glu Asp Ile Ile Gln Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Arg Gln Arg Leu Gln Lys Tyr Ser Asp 
625                 630                 635                 640 


Ile Phe Thr Thr Gln Gln Leu Lys Lys Leu Glu Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asp Lys 
            660                 665                 670         


Gln Ser Asn Lys Thr Ile Leu Gly Tyr Leu Ile Asp Asp Gly Tyr Ser 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ser Leu Pro Phe Lys 
    690                 695                 700                 


Glu Glu Ile Ala Arg Ala Gln Val Ile Gly Glu Thr Asp Asp Leu Asn 
705                 710                 715                 720 


Gln Leu Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val Met Gly His 
            740                 745                 750         


Asn Pro Ala Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr 
        755                 760                 765             


Ala Lys Gly Arg Arg Ser Ser Gln Gln Arg Tyr Lys Arg Leu Glu Glu 
    770                 775                 780                 


Ala Ile Lys Asn Leu Asp His Asp Leu Asn His Lys Ile Leu Lys Glu 
785                 790                 795                 800 


His Pro Thr Asp Asn Gln Ala Leu Gln Asn Asp Arg Leu Phe Leu Tyr 
                805                 810                 815     


Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Glu Asp Pro Leu Asp Ile 
            820                 825                 830         


Asn Arg Leu Ser Asp Tyr Asp Ile Asp His Ile Ile Pro Gln Ser Phe 
        835                 840                 845             


Ile Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Val Ser Ser Ala Lys 
    850                 855                 860                 


Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Asp Val Val Asn Arg 
865                 870                 875                 880 


Met Arg Pro Phe Trp Asn Lys Leu Leu Ser Cys Gly Leu Ile Ser Gln 
                885                 890                 895     


Arg Lys Tyr Ser Asn Leu Thr Lys Lys Glu Leu Lys Pro Asp Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ala Arg Phe Asn Thr Lys Arg Asp Glu 
    930                 935                 940                 


Asn Lys Lys Val Ile Arg Asp Val Lys Ile Ile Thr Leu Lys Ser Asn 
945                 950                 955                 960 


Leu Val Ser Gln Phe Arg Lys Asp Phe Lys Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Ile 
            980                 985                 990         


Gly Lys Ala Leu Leu Asp Val Tyr  Pro Gln Leu Glu Pro  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Glu Tyr Pro His Phe  His Gly Tyr Lys Glu  Asn Lys Ala 
    1010                 1015                 1020             


Thr Ala  Lys Lys Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1025                 1030                 1035             


Lys Asp  Asp Ile Arg Thr Asp  Glu Asn Gly Glu Ile  Val Trp Lys 
    1040                 1045                 1050             


Lys Asp  Glu His Ile Ser Asn  Ile Lys Arg Val Leu  Ser Tyr Pro 
    1055                 1060                 1065             


Gln Val  Asn Ile Val Lys Lys  Val Glu Ile Gln Thr  Val Gly Gln 
    1070                 1075                 1080             


Asn Gly  Gly Leu Phe Asp Asp  Asn Pro Lys Ser Pro  Leu Glu Val 
    1085                 1090                 1095             


Thr Pro  Ser Lys Leu Val Pro  Leu Lys Lys Glu Leu  Asn Pro Lys 
    1100                 1105                 1110             


Lys Tyr  Gly Gly Tyr Gln Lys  Pro Thr Thr Ala Tyr  Pro Val Leu 
    1115                 1120                 1125             


Leu Ile  Thr Asp Thr Lys Gln  Leu Ile Pro Ile Ser  Val Met Asn 
    1130                 1135                 1140             


Lys Lys  Gln Phe Glu Gln Asn  Pro Val Lys Phe Leu  Arg Asp Arg 
    1145                 1150                 1155             


Gly Tyr  Gln Gln Val Gly Lys  Asn Asp Phe Ile Lys  Leu Pro Lys 
    1160                 1165                 1170             


Tyr Thr  Leu Val Asp Ile Gly  Asp Gly Ile Lys Arg  Leu Trp Ala 
    1175                 1180                 1185             


Ser Ser  Lys Glu Ile His Lys  Gly Asn Gln Leu Val  Val Ser Lys 
    1190                 1195                 1200             


Lys Ser  Gln Ile Leu Leu Tyr  His Ala His His Leu  Asp Ser Asp 
    1205                 1210                 1215             


Leu Ser  Asn Asp Tyr Leu Gln  Asn His Asn Gln Gln  Phe Asp Val 
    1220                 1225                 1230             


Leu Phe  Asn Glu Ile Ile Ser  Phe Ser Lys Lys Cys  Lys Leu Gly 
    1235                 1240                 1245             


Lys Glu  His Ile Gln Lys Ile  Glu Asn Val Tyr Ser  Asn Lys Lys 
    1250                 1255                 1260             


Asn Ser  Ala Ser Ile Glu Glu  Leu Ala Glu Ser Phe  Ile Lys Leu 
    1265                 1270                 1275             


Leu Gly  Phe Thr Gln Leu Gly  Ala Thr Ser Pro Phe  Asn Phe Leu 
    1280                 1285                 1290             


Gly Val  Lys Leu Asn Gln Lys  Gln Tyr Lys Gly Lys  Lys Asp Tyr 
    1295                 1300                 1305             


Ile Leu  Pro Cys Thr Glu Gly  Thr Leu Ile Arg Gln  Ser Ile Thr 
    1310                 1315                 1320             


Gly Leu  Tyr Glu Thr Arg Val  Asp Leu Ser Lys Ile  Gly Glu Asp 
    1325                 1330                 1335             


<210> 466
<211> 1130
<212> PRT
<213> Streptococcus macedonicus

<400> 466
Met Thr Asn Gly Lys Ile Leu Gly Leu Asp Ile Gly Ile Ala Ser Val 
1               5                   10                  15      


Gly Val Gly Ile Ile Glu Ala Lys Thr Gly Lys Val Val His Ala Asn 
            20                  25                  30          


Ser Arg Leu Phe Ser Ala Ala Asn Ala Glu Asn Asn Ala Glu Arg Arg 
        35                  40                  45              


Gly Phe Arg Gly Ser Arg Arg Leu Asn Arg Arg Lys Lys His Arg Val 
    50                  55                  60                  


Lys Arg Val Arg Asp Leu Phe Glu Lys Tyr Gly Ile Val Thr Asp Phe 
65                  70                  75                  80  


Arg Asn Leu Asn Leu Asn Pro Tyr Glu Leu Arg Val Lys Gly Leu Thr 
                85                  90                  95      


Glu Gln Leu Thr Asn Glu Glu Leu Phe Ala Ala Leu Arg Thr Ile Ser 
            100                 105                 110         


Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Glu Asp Asp Ser Thr 
        115                 120                 125             


Gly Ser Thr Asp Tyr Ala Lys Ser Ile Asp Glu Asn Arg Arg Leu Leu 
    130                 135                 140                 


Lys Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Leu Glu Lys Tyr 
145                 150                 155                 160 


Gly Gln Leu Arg Gly Asn Phe Thr Val Tyr Asp Glu Asn Gly Glu Ala 
                165                 170                 175     


His Arg Leu Ile Asn Val Phe Ser Thr Ser Asp Tyr Glu Lys Glu Ala 
            180                 185                 190         


Arg Lys Ile Leu Glu Thr Gln Ala Asp Tyr Asn Lys Lys Ile Thr Ala 
        195                 200                 205             


Glu Phe Ile Asp Asp Tyr Val Glu Ile Leu Thr Gln Lys Arg Lys Tyr 
    210                 215                 220                 


Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg Phe 
225                 230                 235                 240 


Arg Thr Asp Gly Thr Thr Leu Glu Asn Ile Phe Gly Ile Leu Ile Gly 
                245                 250                 255     


Lys Cys Asn Phe Tyr Pro Asp Glu Tyr Arg Ala Ser Lys Ala Ser Tyr 
            260                 265                 270         


Thr Ala Gln Glu Tyr Asn Phe Leu Asn Asp Leu Asn Asn Leu Lys Val 
        275                 280                 285             


Pro Thr Glu Thr Gly Lys Leu Ser Thr Glu Gln Lys Glu Ser Leu Val 
    290                 295                 300                 


Glu Phe Ala Lys Asn Thr Ala Ile Leu Gly Pro Ala Lys Leu Leu Lys 
305                 310                 315                 320 


Glu Ile Ala Lys Ile Leu Asp Cys Lys Val Asp Glu Ile Lys Gly Tyr 
                325                 330                 335     


Arg Glu Asp Asp Lys Gly Lys Pro Asp Leu His Thr Phe Glu Pro Tyr 
            340                 345                 350         


Arg Lys Leu Lys Phe Asn Leu Asp Ser Val Asn Ile Asp Tyr Leu Ser 
        355                 360                 365             


Arg Glu Val Leu Asp Lys Leu Ala Asp Ile Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Glu Asp Ala Ile Lys Arg Asn Leu Pro Asn Gln Phe 
385                 390                 395                 400 


Thr Glu Glu Gln Ile Ser Glu Ile Ile Asn Val Arg Lys Ser Gln Ser 
                405                 410                 415     


Thr Ala Phe Asn Lys Gly Trp His Ser Phe Ser Ala Lys Leu Met Asn 
            420                 425                 430         


Glu Leu Ile Pro Glu Leu Tyr Ala Thr Ser Asp Glu Gln Met Thr Ile 
        435                 440                 445             


Leu Thr Arg Leu Glu Lys Phe Lys Val Lys Lys Lys Ser Ser Lys Asn 
    450                 455                 460                 


Ile Lys Thr Ile Asp Glu Lys Glu Ile Thr Asp Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ala Lys Ser Val Arg Gln Thr Ile Lys Ile Ile Asn Ala Ala 
                485                 490                 495     


Val Lys Lys Tyr Gly Asp Phe Asp Lys Ile Val Ile Glu Met Pro Arg 
            500                 505                 510         


Asp Lys Asn Ala Asp Asp Glu Lys Lys Phe Ile Asn Lys Arg Asn Lys 
        515                 520                 525             


Glu Asn Lys Lys Glu Lys Asp Asp Ala Leu Lys Arg Ala Ala Tyr Leu 
    530                 535                 540                 


Tyr Asn Gly Thr Asp Lys Leu Pro Asp Glu Val Phe His Gly Asn Lys 
545                 550                 555                 560 


Gln Leu Glu Thr Lys Ile Arg Leu Trp Tyr Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Leu Tyr Ser Gly Lys Pro Ile Pro Ile Gln Glu Leu Val His Asn Ser 
            580                 585                 590         


Asn Asn Phe Glu Ile Asp His Ile Leu Pro Leu Ser Leu Ser Phe Asp 
        595                 600                 605             


Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ser Trp Thr Asn Gln Glu 
    610                 615                 620                 


Lys Gly Gln Lys Thr Pro Tyr Gln Val Ile Asp Ser Met Asp Ala Ala 
625                 630                 635                 640 


Trp Ser Phe Arg Glu Met Lys Glu Tyr Val Leu Lys Gln Lys Gly Leu 
                645                 650                 655     


Gly Lys Lys Lys Arg Asp Tyr Leu Leu Thr Thr Glu Asn Ile Asp Lys 
            660                 665                 670         


Ile Glu Val Lys Lys Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ser Arg Val Val Leu Asn Ser Leu Gln Ser Ala Leu Arg Glu 
    690                 695                 700                 


Leu Gly Lys Asp Thr Lys Val Ser Val Val Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg Arg Lys Trp Lys Ile Asp Lys Ser Arg Glu Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Lys 
            740                 745                 750         


Leu Trp Glu Lys Gln Asp Asn Pro Met Phe Val Asp Tyr Gly Asn Asn 
        755                 760                 765             


Gln Val Val Asp Lys Gln Thr Gly Glu Ile Leu Ser Val Ser Asp Asn 
    770                 775                 780                 


Glu Tyr Lys Glu Leu Val Phe Gln Pro Pro Tyr Gln Gly Phe Val Asn 
785                 790                 795                 800 


Thr Ile Ser Ser Lys Gly Phe Glu Asp Glu Ile Leu Phe Ser Tyr Gln 
                805                 810                 815     


Val Asp Ser Lys Tyr Asn Arg Lys Val Ser Asp Ala Thr Ile Tyr Ser 
            820                 825                 830         


Thr Arg Lys Ala Lys Ile Gly Lys Asp Lys Lys Glu Glu Thr Tyr Val 
        835                 840                 845             


Leu Gly Lys Ile Lys Asp Ile Tyr Ser Gln Asn Gly Phe Asp Thr Phe 
    850                 855                 860                 


Val Lys Lys Tyr Asn Lys Asp Lys Thr Gln Phe Leu Met Tyr Gln Lys 
865                 870                 875                 880 


Asp Pro Leu Thr Trp Glu Asn Val Ile Glu Val Ile Leu Gly Asp Tyr 
                885                 890                 895     


Pro Thr Thr Lys Lys Ser Glu Asp Gly Lys Asn Asp Val Lys Cys Asn 
            900                 905                 910         


Pro Phe Glu Glu Tyr Arg Arg Glu Asn Gly Leu Ile Cys Lys Tyr Ser 
        915                 920                 925             


Lys Lys Gly Lys Gly Thr Pro Ile Lys Ser Leu Lys Tyr Tyr Asp Lys 
    930                 935                 940                 


Lys Leu Gly Asn Cys Ile Asp Ile Thr Pro Glu Glu Ser Arg Asn Lys 
945                 950                 955                 960 


Val Ile Leu Gln Ser Ile Asn Pro Trp Arg Ala Asp Val Tyr Phe Asn 
                965                 970                 975     


Pro Glu Thr Leu Lys Tyr Glu Leu Met Gly Leu Lys Tyr Ser Asp Leu 
            980                 985                 990         


Ser Phe Glu Lys Gly Thr Gly Asn  Tyr His Ile Ser Gln  Glu Lys Tyr 
        995                 1000                 1005             


Asp Ala  Ile Lys Glu Lys Glu  Gly Ile Gly Lys Lys  Ser Glu Phe 
    1010                 1015                 1020             


Lys Phe  Thr Leu Tyr Arg Asn  Asp Leu Ile Leu Ile  Lys Asp Ile 
    1025                 1030                 1035             


Ala Ser  Gly Glu Gln Glu Ile  Tyr Arg Phe Leu Ser  Arg Thr Met 
    1040                 1045                 1050             


Pro Asn  Val Asn His Tyr Val  Glu Leu Lys Pro Tyr  Asp Lys Glu 
    1055                 1060                 1065             


Lys Phe  Asp Asn Val Gln Glu  Leu Val Glu Ala Leu  Gly Glu Ala 
    1070                 1075                 1080             


Asp Lys  Val Gly Arg Cys Ile  Lys Ser Leu Asn Lys  Pro Asn Ile 
    1085                 1090                 1095             


Ser Ile  Tyr Lys Val Arg Thr  Asp Val Leu Gly Asn  Lys Tyr Phe 
    1100                 1105                 1110             


Val Lys  Lys Glu Gly Asp Lys  Pro Lys Leu Asp Phe  Lys Asn Asn 
    1115                 1120                 1125             


Lys Lys  
    1130 


<210> 467
<211> 1134
<212> PRT
<213> Streptococcus mitis


<220>
<223> Streptococcus mitis ATCC 6249

<400> 467
Met Asn Gly Leu Val Leu Gly Leu Asp Ile Gly Ile Ala Ser Glu Gly 
1               5                   10                  15      


Val Gly Ile Leu Glu Lys Asn Ser Gly Lys Ile Ile His Ala Asn Ser 
            20                  25                  30          


Arg Leu Phe Pro Ala Ala Thr Ala Asp Asn Asn Val Glu Arg Arg Lys 
        35                  40                  45              


Asn Arg Gln Ala Arg Arg Leu Asn Arg Arg Lys Lys His Arg Gly Val 
    50                  55                  60                  


Arg Phe Gln Asp Leu Phe Glu Asp Tyr Gly Leu Leu Thr Asp Phe Ser 
65                  70                  75                  80  


Lys Val Ser Ile Asn Leu Asn Pro Tyr Arg Leu Arg Val Asp Gly Leu 
                85                  90                  95      


Asn Gln Gln Leu Thr Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Ile 
            100                 105                 110         


Val Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Glu Asp Gly 
        115                 120                 125             


Gly Ala Val Ser Ser Asp Tyr Gly Lys Ala Val Glu Glu Asn Arg Lys 
    130                 135                 140                 


Leu Leu Ala Glu Gln Thr Pro Gly Gln Ile Gln Leu Glu Arg Phe Glu 
145                 150                 155                 160 


Lys Tyr Gly Gln Val Arg Gly Asp Phe Thr Val Val Glu Asn Gly Glu 
                165                 170                 175     


Lys Leu Arg Leu Ile Asn Val Phe Ser Thr Ser Ala Tyr Lys Lys Glu 
            180                 185                 190         


Ala Glu Arg Ile Leu Arg Lys Gln Gln Glu Phe Asn Asn Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Glu Asp Tyr Leu Lys Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Phe Arg Thr Asp Gly Thr Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Glu Glu Tyr Arg Ala Ser Lys Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Glu Glu Gln Lys Lys Val Ile 
    290                 295                 300                 


Val Glu Tyr Ala Lys Glu Ala Lys Thr Leu Gly Ala Ser Thr Leu Leu 
305                 310                 315                 320 


Lys Tyr Ile Ala Lys Met Ile Asp Ala Ser Val Asp Gln Ile Arg Gly 
                325                 330                 335     


Tyr Arg Val Asp Val Asn Asn Lys Pro Glu Met His Thr Phe Glu Val 
            340                 345                 350         


Tyr Arg Lys Met Gln Ser Leu Glu Thr Ile Ser Val Gly Glu Leu Ser 
        355                 360                 365             


Arg Asn Val Leu Asp Glu Leu Ala His Ile Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Met Glu Glu Ala Ile Asn Thr Lys Leu Lys Asp Ser Phe 
385                 390                 395                 400 


Ser Gln Asp Gln Val Leu Glu Leu Val Gln Phe Arg Lys Asn Asn Ser 
                405                 410                 415     


Ser Leu Phe Ser Lys Gly Trp His Asn Phe Ser Leu Lys Leu Met Met 
            420                 425                 430         


Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr Ile 
        435                 440                 445             


Leu Thr Arg Leu Gly Lys Gln Lys Ser Lys Glu Thr Ser Lys Arg Thr 
    450                 455                 460                 


Lys Tyr Ile Asp Glu Lys Glu Leu Thr Glu Glu Ile Tyr Asn Pro Val 
465                 470                 475                 480 


Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Ile Asn Glu Ala Thr 
                485                 490                 495     


Lys Lys His Gly Ile Phe Asp Asn Ile Val Ile Glu Met Ala Arg Glu 
            500                 505                 510         


Asn Asn Glu Glu Asp Ala Lys Lys Asp Tyr Ile Lys Arg Gln Lys Ala 
        515                 520                 525             


Asn Gln Asp Glu Lys Asn Ala Ala Met Glu Lys Ala Ala Phe Gln Tyr 
    530                 535                 540                 


Asn Gly Lys Lys Glu Leu Pro Asp Asn Ile Phe His Gly His Lys Glu 
545                 550                 555                 560 


Leu Ala Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Lys Cys Leu 
                565                 570                 575     


Tyr Thr Gly Lys Thr Ile Pro Ile Ser Asp Leu Ile Tyr Asn Gln Tyr 
            580                 585                 590         


Lys Tyr Glu Ile Asp His Ile Leu Pro Leu Ser Leu Ser Phe Asp Asp 
        595                 600                 605             


Ser Leu Ser Asn Lys Val Leu Ala Leu Ala Thr Ala Asn Gln Glu Lys 
    610                 615                 620                 


Gly Gln Arg Thr Pro Phe Gln Ala Leu Asp Ser Met Asp Asp Ala Trp 
625                 630                 635                 640 


Ser Tyr Arg Glu Phe Lys Ser Tyr Val Lys Asp Leu Lys Ser Leu Ser 
                645                 650                 655     


Asn Lys Lys Lys Asp Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys Ile 
            660                 665                 670         


Glu Val Lys Gln Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg Tyr 
        675                 680                 685             


Ser Ser Arg Val Val Leu Asn Ala Leu Gln Asp Phe Tyr Lys Ser His 
    690                 695                 700                 


Gln Phe Asp Thr Thr Ile Ser Val Val Arg Gly Gln Phe Thr Ser Gln 
705                 710                 715                 720 


Leu Arg Arg Lys Trp Gly Leu Glu Lys Ser Arg Glu Thr Tyr His His 
                725                 730                 735     


His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Arg Leu 
            740                 745                 750         


Trp Lys Lys Gln Asn Asn Pro Leu Ile Thr Tyr Lys Glu Gly Gln Phe 
        755                 760                 765             


Val Asp Ser Gln Thr Gly Glu Ile Ile Ser Leu Thr Asp Asp Glu Tyr 
    770                 775                 780                 


Lys Glu Leu Val Phe Lys Ala Pro Tyr Asp His Phe Val Asp Thr Leu 
785                 790                 795                 800 


Ser Ser Lys Thr Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln Val Asp 
                805                 810                 815     


Ser Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg 
            820                 825                 830         


Lys Ala Lys Leu Asp Lys Glu Lys Lys Glu Tyr Thr Tyr Thr Leu Gly 
        835                 840                 845             


Lys Ile Lys Asp Ile Tyr Ser Leu Gly Thr Lys Thr Pro Ser Lys Thr 
    850                 855                 860                 


Gly Phe Tyr Lys Phe Leu Asp Leu Tyr Asn Lys Asp Lys Ser Gln Phe 
865                 870                 875                 880 


Leu Met Phe Gln Lys Asp Arg Lys Thr Trp Asp Glu Val Ile Glu Lys 
                885                 890                 895     


Ile Met Glu Gln Tyr Arg Pro Phe Lys Glu Tyr Asp Lys Thr Gly Lys 
            900                 905                 910         


Leu Val Asp Phe Asn Pro Phe Glu Lys Tyr Arg Gln Glu Asn Glu Pro 
        915                 920                 925             


Ile Arg Lys Tyr Ser Lys Lys Gly Asn Gly Pro Glu Ile Lys Ser Leu 
    930                 935                 940                 


Lys Tyr Tyr Asp Ile Leu Leu Gly Lys His Lys Asn Ile Thr Pro Glu 
945                 950                 955                 960 


Gly Ser Arg Asn Thr Val Ala Leu Leu Ser Leu Asn Pro Trp Arg Thr 
                965                 970                 975     


Asp Val Tyr Tyr Asn Met Glu Thr Lys Lys Tyr Glu Phe Leu Gly Leu 
            980                 985                 990         


Lys Tyr Ala Asp Leu Pro Phe Glu  Glu Gly Gly Ala Tyr  Gly Ile Ser 
        995                 1000                 1005             


Thr Glu  Thr Tyr Asn Glu Leu  Arg Glu Lys Glu Gly  Ile Gly Lys 
    1010                 1015                 1020             


Asn Ser  Glu Phe Lys Phe Thr  Leu Tyr Lys Asn Asp  Leu Ile Leu 
    1025                 1030                 1035             


Ile Lys  Asp Thr Glu Thr Asn  Cys Gln Gln Ile Phe  Arg Phe Trp 
    1040                 1045                 1050             


Ser Arg  Thr Gly Lys Asp Asn  Pro Lys Ser Phe Glu  Lys His Lys 
    1055                 1060                 1065             


Ile Glu  Leu Lys Pro Tyr Glu  Lys Ala Arg Phe Glu  Lys Gly Glu 
    1070                 1075                 1080             


Glu Leu  Glu Val Leu Gly Lys  Val Pro Pro Ser Ser  Asn Gln Leu 
    1085                 1090                 1095             


Gln Lys  Asn Met Gln Ile Glu  Asn Leu Ser Ile Tyr  Lys Val Lys 
    1100                 1105                 1110             


Thr Asp  Val Leu Gly Asn Lys  His Phe Ile Lys Lys  Glu Gly Asp 
    1115                 1120                 1125             


Lys Pro  Lys Leu Lys Phe 
    1130                 


<210> 468
<211> 1392
<212> PRT
<213> Streptococcus mitis


<220>
<223> Streptococcus mitis SK321

<400> 468
Met Asn Asn Asn Asn Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys His Phe Ile Lys Lys Asn Leu 
        35                  40                  45              


Ile Gly Ala Leu Leu Phe Asp Glu Gly Ala Thr Ala Glu Asp Arg Arg 
    50                  55                  60                  


Phe Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Ser Lys Val Asp Ser 
                85                  90                  95      


Ser Phe Phe His Arg Leu Asp Asp Ser Phe Leu Val Pro Glu Asp Lys 
            100                 105                 110         


Arg Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Ala Glu Glu Lys Glu 
        115                 120                 125             


Tyr His Lys Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala 
    130                 135                 140                 


Asp Ser Lys Glu Lys Thr Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Glu Ser Phe Asp 
                165                 170                 175     


Ile Lys Asn Asn Asp Ile Gln Lys Ile Phe Ser Glu Phe Ile Ser Ile 
            180                 185                 190         


Tyr Asp Asn Thr Phe Glu Gly Ser Ser Leu Ser Gly Gln Asn Ala Gln 
        195                 200                 205             


Val Glu Ala Ile Phe Thr Asp Lys Ile Ser Lys Ser Ala Lys Arg Glu 
    210                 215                 220                 


Arg Ile Leu Lys Leu Phe Ala Tyr Glu Lys Ser Thr Asp Leu Phe Ser 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asp Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Asp Phe Ala 
        275                 280                 285             


Asp Leu Phe Leu Val Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Glu Arg Tyr Glu Asn His Gln Lys Asp Leu Ala Ala Leu 
                325                 330                 335     


Lys Gln Phe Ile Gln Asn Asn Leu Gln Glu Lys Tyr Asp Glu Val Phe 
            340                 345                 350         


Ser Asp Gln Ser Lys Asp Gly Tyr Ala Arg Tyr Ile Asn Gly Lys Thr 
        355                 360                 365             


Thr Gln Glu Ala Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe 
    370                 375                 380                 


Glu Gly Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met Asn Ala Ile Ile Arg Arg Gln Gly Glu His Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Tyr Lys Glu Lys Ile Glu Thr Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Arg Asn Phe Ala 
    450                 455                 460                 


Trp Leu Thr Arg Asn Ser Asp Gln Ala Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Ile Val Asp Gln Ala Ser Ser Ala Glu Glu Phe Ile Asn Lys Met 
                485                 490                 495     


Thr Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Phe Ile Ser Glu Gly Leu Arg Asp Tyr Gln Phe Leu Asp Ser Gly 
    530                 535                 540                 


Gln Lys Lys Gln Ile Val Asn Gln Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile Gln Tyr Leu His Asn Val Asp Gly Tyr Asp 
                565                 570                 575     


Gly Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Glu Phe Met Asp 
        595                 600                 605             


Asp Pro Lys Asn Glu Glu Ile Leu Glu Asn Ile Val His Thr Leu Thr 
    610                 615                 620                 


Ile Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Gln Tyr Ala 
625                 630                 635                 640 


Ser Ile Phe Asp Lys Lys Val Ile Lys Ala Leu Thr Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Cys Asp 
            660                 665                 670         


Lys Lys Thr Gly Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Tyr 
        675                 680                 685             


Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu Ser Phe 
    690                 695                 700                 


Lys Asp Ile Ile Gln Lys Ala Gln Val Val Gly Lys Thr Asn Asp Val 
705                 710                 715                 720 


Lys Gln Val Val Gln Glu Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Ile Lys Leu Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Ala Pro Glu Ser Ile Val Ile Glu Ile Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Ala Arg Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg Ile Glu 
    770                 775                 780                 


Asp Ala Leu Lys Asn Leu Ala Pro Gly Leu Asp Ser Asn Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asp Asn Ile Gln Leu Gln Asn Asp Arg Leu Phe Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Glu Ala Leu Asp 
            820                 825                 830         


Ile Asn Gln Leu Ser Ser Tyr Asp Ile Asp His Ile Val Pro Gln Ala 
        835                 840                 845             


Phe Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser Ser Lys 
    850                 855                 860                 


Asp Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Leu Glu Val Val Gln 
865                 870                 875                 880 


Lys Arg Lys Ala Phe Trp Gln Gln Leu Leu Asp Ser Lys Leu Ile Ser 
                885                 890                 895     


Glu His Lys Phe Asn Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Asp 
            900                 905                 910         


Glu Arg Asp Lys Val Gly Phe Ile Arg Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ala Arg Phe Asn Thr 
    930                 935                 940                 


Glu Val Asn Glu Lys Asp Lys Lys Asn Arg Thr Val Lys Ile Ile Thr 
945                 950                 955                 960 


Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Lys Leu Tyr 
                965                 970                 975     


Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Ala Val Val Ala Lys Ala Ile  Leu Lys Lys Tyr Pro  Lys Leu Glu 
        995                 1000                 1005             


Pro Gly  Phe Val Tyr Gly Asp  Tyr Gln Lys Tyr Asp  Ile Lys Arg 
    1010                 1015                 1020             


Tyr Ile  Ser Arg Ser Lys Asp  Pro Lys Glu Val Glu  Lys Ala Thr 
    1025                 1030                 1035             


Glu Lys  Tyr Phe Phe Tyr Ser  Asn Leu Leu Asn Phe  Phe Lys Glu 
    1040                 1045                 1050             


Glu Val  His Tyr Ala Asp Gly  Thr Ile Val Lys Arg  Glu Asn Ile 
    1055                 1060                 1065             


Glu Tyr  Ser Lys Asp Thr Gly  Glu Ile Ala Trp Asn  Lys Glu Lys 
    1070                 1075                 1080             


Asp Phe  Ala Thr Ile Lys Lys  Val Leu Ser Leu Pro  Gln Val Asn 
    1085                 1090                 1095             


Ile Val  Lys Lys Thr Glu Ile  Gln Thr His Gly Leu  Asp Arg Gly 
    1100                 1105                 1110             


Lys Pro  Arg Gly Leu Phe Asn  Ser Asn Pro Ser Pro  Lys Pro Ser 
    1115                 1120                 1125             


Glu Asp  Arg Lys Glu Asn Leu  Val Pro Ile Lys Gln  Gly Leu Asp 
    1130                 1135                 1140             


Pro Arg  Lys Tyr Gly Gly Tyr  Ala Gly Ile Ser Asn  Ser Tyr Ala 
    1145                 1150                 1155             


Val Leu  Val Lys Ala Ile Ile  Glu Lys Gly Ala Lys  Lys Gln Gln 
    1160                 1165                 1170             


Lys Thr  Val Leu Glu Phe Gln  Gly Ile Ser Ile Leu  Asp Lys Ile 
    1175                 1180                 1185             


Asn Phe  Glu Lys Asn Lys Glu  Asn Tyr Leu Leu Glu  Lys Gly Tyr 
    1190                 1195                 1200             


Ile Lys  Ile Leu Ser Thr Ile  Thr Leu Pro Lys Tyr  Ser Leu Phe 
    1205                 1210                 1215             


Glu Phe  Pro Asp Gly Thr Arg  Arg Arg Leu Ala Ser  Ile Leu Ser 
    1220                 1225                 1230             


Thr Asn  Asn Lys Arg Gly Glu  Ile His Lys Gly Asn  Glu Leu Val 
    1235                 1240                 1245             


Ile Pro  Glu Lys Tyr Thr Thr  Leu Leu Tyr His Ala  Lys Asn Ile 
    1250                 1255                 1260             


Asn Lys  Thr Leu Glu Pro Glu  His Leu Glu Tyr Val  Glu Lys His 
    1265                 1270                 1275             


Arg Asn  Asp Phe Ala Lys Leu  Leu Glu Tyr Val Leu  Asn Phe Asn 
    1280                 1285                 1290             


Asp Lys  Tyr Val Gly Ala Leu  Lys Asn Gly Glu Arg  Ile Arg Gln 
    1295                 1300                 1305             


Ala Phe  Ile Asp Trp Glu Thr  Val Asp Ile Glu Lys  Leu Cys Phe 
    1310                 1315                 1320             


Ser Phe  Ile Gly Pro Arg Asn  Ser Lys Asn Ala Gly  Leu Phe Glu 
    1325                 1330                 1335             


Leu Thr  Ser Gln Gly Ser Ala  Ser Asp Phe Glu Phe  Leu Gly Val 
    1340                 1345                 1350             


Lys Ile  Pro Arg Tyr Arg Asp  Tyr Thr Pro Ser Ser  Leu Leu Asn 
    1355                 1360                 1365             


Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1370                 1375                 1380             


Ile Asp  Leu Ser Lys Leu Gly  Glu Asp 
    1385                 1390         


<210> 469
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 11SSST2

<400> 469
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Thr Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Leu Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Pro Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Glu  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ser Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Ala  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 470
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 11SSST2

<400> 470
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Thr Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Leu Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Pro Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Glu  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ser Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Ala  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 471
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 11VS1

<400> 471
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Lys Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 472
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 14D

<400> 472
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu His Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 473
<211> 1355
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 15VF2

<400> 473
Met Lys Lys Ser Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Asp Glu Ser Phe Leu Thr Asp Asp Asp Lys Asn 
            100                 105                 110         


Phe Asp Ser His Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala Tyr 
        115                 120                 125             


His Gln Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ser Thr Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Lys Leu Phe Ala Asp Phe Val Gly Val Tyr 
            180                 185                 190         


Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Ser Ser Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu Lys 
    210                 215                 220                 


Leu Ile Asn Asn Tyr Pro Lys Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Thr Leu Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Ala Glu His His Glu Asp Leu Glu Lys Leu Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Asn Lys Pro Glu Leu Tyr His Asp Ile Phe Lys 
            340                 345                 350         


Asp Glu Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val Lys 
        355                 360                 365             


Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Asn Thr Leu Ser Lys Ile Ala 
    370                 375                 380                 


Gly Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Asp Tyr Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Ala Glu Tyr His Ser Asp Glu Ala Val Met Pro Trp Asn Phe Asp Gln 
465                 470                 475                 480 


Val Ile Asp Lys Glu Ser Ser Ala Gln Ala Phe Ile Glu His Met Thr 
                485                 490                 495     


Asn Asn Asp Leu Tyr Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Pro Leu Tyr Glu Lys Tyr Thr Val Tyr Asn Glu Leu Thr Lys Ile Lys 
        515                 520                 525             


Tyr Val Thr Glu Ile Gly Glu Ala Lys Phe Phe Asp Ala Asn Leu Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Leu Phe Lys His Glu Arg Lys Val Thr Lys 
545                 550                 555                 560 


Lys Lys Leu Arg Thr Phe Leu Asp Lys Asn Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Ile Gln Gly Leu Asp Lys Glu Thr Glu Thr Phe Asn Ala Ser 
            580                 585                 590         


Tyr Ala Thr Tyr Gln Asp Leu Leu Lys Val Ile Lys Asp Lys Val Phe 
        595                 600                 605             


Met Asp Asn Pro Glu Asn Ala Glu Ile Leu Glu Asn Ile Val Leu Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Lys 
625                 630                 635                 640 


Tyr Ala Asp Val Phe Asp Lys Lys Val Ile Asp Gln Leu Ala Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Gln Ser Cys Lys Thr Ile Met Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Ala Gln Ser Asn Arg Asn Leu Met Gln Leu Ile Thr Asp Asp Asn Leu 
    690                 695                 700                 


Thr Phe Lys Asp Asp Ile Val Lys Ala Gln Tyr Val Asp Asn Ser Asp 
705                 710                 715                 720 


Asp Leu His Gln Val Val Gln Ser Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Lys Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Ala Lys Gly Arg Arg Asn Ser Gln Gln Arg Tyr Lys Arg 
    770                 775                 780                 


Leu Lys Glu Ala Ile Lys Ser Leu Asp Arg Asp Leu Asn His Lys Ile 
785                 790                 795                 800 


Leu Lys Glu His Pro Thr Asp Asn Gln Ala Leu Gln Asn Asn Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ser 
            820                 825                 830         


Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Ile Asp His Val Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser 
    850                 855                 860                 


Ser Lys Ala Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Glu Asp Val 
865                 870                 875                 880 


Val Asn Arg Met Arg Pro Phe Trp Asn Lys Leu Leu Ser Ser Gly Leu 
                885                 890                 895     


Ile Ser Gln Arg Lys Tyr Asn Asn Leu Thr Lys Lys Glu Leu Thr Pro 
            900                 905                 910         


Asp Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln 
        915                 920                 925             


Ile Thr Lys His Val Ala Arg Met Leu Asp Glu Arg Phe Asn Lys Glu 
    930                 935                 940                 


Phe Asp Asp Asn Asn Lys Arg Ile Arg Arg Val Lys Ile Val Thr Leu 
945                 950                 955                 960 


Lys Ser Asn Leu Val Ser Ser Phe Arg Lys Glu Phe Glu Leu Tyr Lys 
                965                 970                 975     


Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn 
            980                 985                 990         


Ala Val Val Val Lys Ala Leu Leu  Val Lys Tyr Pro Lys  Leu Glu Pro 
        995                 1000                 1005             


Glu Phe  Val Tyr Gly Glu Tyr  Pro Lys Tyr Asn Ser  Tyr Arg Glu 
    1010                 1015                 1020             


Arg Lys  Thr Ala Thr Gln Lys  Met Phe Phe Tyr Ser  Asn Ile Met 
    1025                 1030                 1035             


Asn Met  Phe Lys Ser Lys Val  Lys Leu Ala Asp Asp  Gln Ile Val 
    1040                 1045                 1050             


Glu Arg  Pro Met Ile Glu Val  Asn Asp Glu Thr Gly  Glu Ile Ala 
    1055                 1060                 1065             


Trp Asp  Lys Thr Lys His Ile  Thr Thr Val Lys Lys  Val Leu Ser 
    1070                 1075                 1080             


Tyr Pro  Gln Val Asn Ile Val  Lys Lys Val Glu Glu  Gln Thr Ile 
    1085                 1090                 1095             


Gly Gln  Asn Gly Gly Leu Phe  Asp Asp Asn Pro Lys  Ser Pro Leu 
    1100                 1105                 1110             


Glu Val  Ile Pro Ser Lys Leu  Val Pro Leu Lys Lys  Ala Leu Asn 
    1115                 1120                 1125             


Pro Glu  Lys Tyr Gly Gly Tyr  Gln Lys Pro Thr Thr  Ala Tyr Pro 
    1130                 1135                 1140             


Ile Leu  Leu Ile Val Asp Thr  Lys Gln Leu Ile Pro  Ile Ser Val 
    1145                 1150                 1155             


Met Asp  Lys Lys Arg Phe Glu  Gln Asn Pro Val Lys  Phe Leu Lys 
    1160                 1165                 1170             


Asp Lys  Gly Tyr Gln Gln Ile  Glu Lys Asn Asn Phe  Val Lys Leu 
    1175                 1180                 1185             


Pro Lys  Tyr Thr Leu Val Asp  Ile Gly Asn Gly Ile  Lys Arg Leu 
    1190                 1195                 1200             


Trp Ala  Ser Ser Lys Glu Val  His Lys Gly Asn Gln  Leu Val Val 
    1205                 1210                 1215             


Ser Lys  Lys Ser Gln Asp Leu  Leu Tyr His Ala His  His Leu Asp 
    1220                 1225                 1230             


Asn Asp  Tyr Ser Asn Glu Tyr  Val Lys Asn His Tyr  Gln Gln Phe 
    1235                 1240                 1245             


Asp Ile  Leu Phe Asn Glu Ile  Thr Ser Phe Ser Lys  Lys Cys Lys 
    1250                 1255                 1260             


Leu Gly  Lys Glu His Ile Gln  Lys Ile Glu Glu Ala  Tyr Ser Lys 
    1265                 1270                 1275             


Glu Arg  Asp Ser Ala Ser Ile  Glu Glu Leu Ala Asp  Gly Phe Ile 
    1280                 1285                 1290             


Lys Leu  Leu Gly Phe Thr Gln  Leu Gly Ala Thr Ser  Pro Phe Ser 
    1295                 1300                 1305             


Phe Leu  Gly Ile Lys Leu Asn  Gln Lys Gln Tyr Thr  Gly Lys Lys 
    1310                 1315                 1320             


Asp Tyr  Leu Leu Pro Cys Met  Glu Ala Thr Leu Ile  His Gln Ser 
    1325                 1330                 1335             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Asn  Lys Leu Gly 
    1340                 1345                 1350             


Gly Asp  
    1355 


<210> 474
<211> 1355
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 15VF2

<400> 474
Met Lys Lys Ser Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Asp Glu Ser Phe Leu Thr Asp Asp Asp Lys Asn 
            100                 105                 110         


Phe Asp Ser His Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala Tyr 
        115                 120                 125             


His Gln Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ser Thr Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Lys Leu Phe Ala Asp Phe Val Gly Val Tyr 
            180                 185                 190         


Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Ser Ser Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu Lys 
    210                 215                 220                 


Leu Ile Asn Asn Tyr Pro Lys Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Thr Leu Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Ala Glu His His Glu Asp Leu Glu Lys Leu Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Asn Lys Pro Glu Leu Tyr His Asp Ile Phe Lys 
            340                 345                 350         


Asp Glu Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val Lys 
        355                 360                 365             


Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Asn Thr Leu Ser Lys Ile Ala 
    370                 375                 380                 


Gly Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Asp Tyr Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Ala Glu Tyr His Ser Asp Glu Ala Val Met Pro Trp Asn Phe Asp Gln 
465                 470                 475                 480 


Val Ile Asp Lys Glu Ser Ser Ala Gln Ala Phe Ile Glu His Met Thr 
                485                 490                 495     


Asn Asn Asp Leu Tyr Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Pro Leu Tyr Glu Lys Tyr Thr Val Tyr Asn Glu Leu Thr Lys Ile Lys 
        515                 520                 525             


Tyr Val Thr Glu Ile Gly Glu Ala Lys Phe Phe Asp Ala Asn Leu Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Leu Phe Lys His Glu Arg Lys Val Thr Lys 
545                 550                 555                 560 


Lys Lys Leu Arg Thr Phe Leu Asp Lys Asn Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Ile Gln Gly Leu Asp Lys Glu Thr Glu Thr Phe Asn Ala Ser 
            580                 585                 590         


Tyr Ala Thr Tyr Gln Asp Leu Leu Lys Val Ile Lys Asp Lys Val Phe 
        595                 600                 605             


Met Asp Asn Pro Glu Asn Ala Glu Ile Leu Glu Asn Ile Val Leu Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Lys 
625                 630                 635                 640 


Tyr Ala Asp Val Phe Asp Lys Lys Val Ile Asp Gln Leu Ala Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Gln Ser Cys Lys Thr Ile Met Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Ala Gln Ser Asn Arg Asn Leu Met Gln Leu Ile Thr Asp Asp Asn Leu 
    690                 695                 700                 


Thr Phe Lys Asp Asp Ile Val Lys Ala Gln Tyr Val Asp Asn Ser Asp 
705                 710                 715                 720 


Asp Leu His Gln Val Val Gln Ser Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Lys Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Ala Lys Gly Arg Arg Asn Ser Gln Gln Arg Tyr Lys Arg 
    770                 775                 780                 


Leu Lys Glu Ala Ile Lys Ser Leu Asp Arg Asp Leu Asn His Lys Ile 
785                 790                 795                 800 


Leu Lys Glu His Pro Thr Asp Asn Gln Ala Leu Gln Asn Asn Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ser 
            820                 825                 830         


Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Ile Asp His Val Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser 
    850                 855                 860                 


Ser Lys Ala Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Glu Asp Val 
865                 870                 875                 880 


Val Asn Arg Met Arg Pro Phe Trp Asn Lys Leu Leu Ser Ser Gly Leu 
                885                 890                 895     


Ile Ser Gln Arg Lys Tyr Asn Asn Leu Thr Lys Lys Glu Leu Thr Pro 
            900                 905                 910         


Asp Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln 
        915                 920                 925             


Ile Thr Lys His Val Ala Arg Met Leu Asp Glu Arg Phe Asn Lys Glu 
    930                 935                 940                 


Phe Asp Asp Asn Asn Lys Arg Ile Arg Arg Val Lys Ile Val Thr Leu 
945                 950                 955                 960 


Lys Ser Asn Leu Val Ser Ser Phe Arg Lys Glu Phe Glu Leu Tyr Lys 
                965                 970                 975     


Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn 
            980                 985                 990         


Ala Val Val Val Lys Ala Leu Leu  Val Lys Tyr Pro Lys  Leu Glu Pro 
        995                 1000                 1005             


Glu Phe  Val Tyr Gly Glu Tyr  Pro Lys Tyr Asn Ser  Tyr Arg Glu 
    1010                 1015                 1020             


Arg Lys  Thr Ala Thr Gln Lys  Met Phe Phe Tyr Ser  Asn Ile Met 
    1025                 1030                 1035             


Asn Met  Phe Lys Ser Lys Val  Lys Leu Ala Asp Asp  Gln Ile Val 
    1040                 1045                 1050             


Glu Arg  Pro Met Ile Glu Val  Asn Asp Glu Thr Gly  Glu Ile Ala 
    1055                 1060                 1065             


Trp Asp  Lys Thr Lys His Ile  Thr Thr Val Lys Lys  Val Leu Ser 
    1070                 1075                 1080             


Tyr Pro  Gln Val Asn Ile Val  Lys Lys Val Glu Glu  Gln Thr Ile 
    1085                 1090                 1095             


Gly Gln  Asn Gly Gly Leu Phe  Asp Asp Asn Pro Lys  Ser Pro Leu 
    1100                 1105                 1110             


Glu Val  Ile Pro Ser Lys Leu  Val Pro Leu Lys Lys  Ala Leu Asn 
    1115                 1120                 1125             


Pro Glu  Lys Tyr Gly Gly Tyr  Gln Lys Pro Thr Thr  Ala Tyr Pro 
    1130                 1135                 1140             


Ile Leu  Leu Ile Val Asp Thr  Lys Gln Leu Ile Pro  Ile Ser Val 
    1145                 1150                 1155             


Met Asp  Lys Lys Arg Phe Glu  Gln Asn Pro Val Lys  Phe Leu Lys 
    1160                 1165                 1170             


Asp Lys  Gly Tyr Gln Gln Ile  Glu Lys Asn Asn Phe  Val Lys Leu 
    1175                 1180                 1185             


Pro Lys  Tyr Thr Leu Val Asp  Ile Gly Asn Gly Ile  Lys Arg Leu 
    1190                 1195                 1200             


Trp Ala  Ser Ser Lys Glu Val  His Lys Gly Asn Gln  Leu Val Val 
    1205                 1210                 1215             


Ser Lys  Lys Ser Gln Asp Leu  Leu Tyr His Ala His  His Leu Asp 
    1220                 1225                 1230             


Asn Asp  Tyr Ser Asn Glu Tyr  Val Lys Asn His Tyr  Gln Gln Phe 
    1235                 1240                 1245             


Asp Ile  Leu Phe Asn Glu Ile  Thr Ser Phe Ser Lys  Lys Cys Lys 
    1250                 1255                 1260             


Leu Gly  Lys Glu His Ile Gln  Lys Ile Glu Glu Ala  Tyr Ser Lys 
    1265                 1270                 1275             


Glu Arg  Asp Ser Ala Ser Ile  Glu Glu Leu Ala Asp  Gly Phe Ile 
    1280                 1285                 1290             


Lys Leu  Leu Gly Phe Thr Gln  Leu Gly Ala Thr Ser  Pro Phe Ser 
    1295                 1300                 1305             


Phe Leu  Gly Ile Lys Leu Asn  Gln Lys Gln Tyr Thr  Gly Lys Lys 
    1310                 1315                 1320             


Asp Tyr  Leu Leu Pro Cys Met  Glu Ala Thr Leu Ile  His Gln Ser 
    1325                 1330                 1335             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Asn  Lys Leu Gly 
    1340                 1345                 1350             


Gly Asp  
    1355 


<210> 475
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 1SM1

<400> 475
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Thr Leu Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 476
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 1SM1

<400> 476
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Thr Leu Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 477
<211> 1350
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 24

<400> 477
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Thr Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Gln Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Glu Asp Val Val Asn Arg Met Arg 
865                 870                 875                 880 


Pro Phe Trp Asn Lys Leu Leu Ser Ser Gly Leu Ile Ser Gln Arg Lys 
                885                 890                 895     


Tyr Asn Asn Leu Thr Lys Lys Glu Leu Thr Leu Asp Asp Lys Ala Gly 
            900                 905                 910         


Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val 
        915                 920                 925             


Ala Arg Met Leu Asp Glu Arg Phe Asn Lys Glu Phe Asp Asp Asn Asn 
    930                 935                 940                 


Lys Arg Ile Cys Lys Val Lys Ile Val Thr Leu Lys Ser Asn Leu Val 
945                 950                 955                 960 


Ser Ser Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg Glu Ile Asn 
                965                 970                 975     


Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val Val Lys 
            980                 985                 990         


Ala Leu Leu Val Lys Tyr Ser Lys  Leu Glu Pro Glu Phe  Val Tyr Gly 
        995                 1000                 1005             


Glu Tyr  Pro Lys Tyr Asn Ser  Tyr Arg Glu Arg Lys  Thr Ala Thr 
    1010                 1015                 1020             


Gln Lys  Met Phe Phe Tyr Ser  Asn Ile Met Asn Met  Phe Lys Ser 
    1025                 1030                 1035             


Lys Val  Lys Leu Ala Asp Asp  Gln Ile Val Glu Arg  Pro Met Ile 
    1040                 1045                 1050             


Glu Val  Asn Asp Glu Thr Gly  Glu Ile Ala Trp Asp  Lys Thr Lys 
    1055                 1060                 1065             


His Ile  Thr Thr Val Lys Lys  Val Leu Ser Tyr Pro  Gln Val Asn 
    1070                 1075                 1080             


Ile Val  Lys Lys Val Glu Glu  Gln Thr Ile Gly Gln  Asn Gly Gly 
    1085                 1090                 1095             


Leu Phe  Asp Asp Asn Pro Lys  Ser Pro Leu Glu Val  Ile Pro Ser 
    1100                 1105                 1110             


Lys Leu  Val Pro Leu Lys Lys  Ala Leu Asn Pro Glu  Lys Tyr Gly 
    1115                 1120                 1125             


Gly Tyr  Gln Lys Pro Thr Thr  Ala Tyr Pro Ile Leu  Leu Ile Val 
    1130                 1135                 1140             


Asp Thr  Lys Gln Leu Ile Pro  Ile Ser Val Met Asp  Lys Lys Arg 
    1145                 1150                 1155             


Phe Glu  Gln Asn Pro Val Lys  Phe Leu Lys Asp Lys  Gly Tyr Gln 
    1160                 1165                 1170             


Gln Ile  Glu Lys Asn Asn Phe  Val Lys Leu Pro Lys  Tyr Thr Leu 
    1175                 1180                 1185             


Val Asp  Ile Gly Asn Gly Ile  Lys Arg Leu Trp Ala  Ser Ser Lys 
    1190                 1195                 1200             


Glu Val  His Lys Gly Asn Gln  Leu Val Val Ser Lys  Lys Ser Gln 
    1205                 1210                 1215             


Asp Leu  Leu Tyr His Ala His  His Leu Asp Asn Asp  Tyr Ser Asn 
    1220                 1225                 1230             


Glu Tyr  Val Lys Asn His Tyr  Gln Gln Phe Asp Ile  Leu Phe Asn 
    1235                 1240                 1245             


Glu Ile  Thr Ser Phe Ser Lys  Lys Cys Lys Leu Gly  Lys Glu His 
    1250                 1255                 1260             


Ile Gln  Lys Ile Glu Glu Ala  Tyr Ser Lys Glu Arg  Asp Ser Ala 
    1265                 1270                 1275             


Ser Ile  Glu Glu Leu Ala Asp  Gly Phe Ile Lys Leu  Leu Gly Phe 
    1280                 1285                 1290             


Thr Gln  Leu Gly Ala Thr Ser  Pro Phe Ser Phe Leu  Gly Ile Lys 
    1295                 1300                 1305             


Leu Asn  Gln Lys Gln Tyr Thr  Gly Lys Lys Asp Tyr  Leu Leu Pro 
    1310                 1315                 1320             


Cys Met  Glu Ala Thr Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr 
    1325                 1330                 1335             


Glu Thr  Arg Ile Asp Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345                 1350 


<210> 478
<211> 1350
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 24

<400> 478
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Thr Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Gln Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Glu Asp Val Val Asn Arg Met Arg 
865                 870                 875                 880 


Pro Phe Trp Asn Lys Leu Leu Ser Ser Gly Leu Ile Ser Gln Arg Lys 
                885                 890                 895     


Tyr Asn Asn Leu Thr Lys Lys Glu Leu Thr Leu Asp Asp Lys Ala Gly 
            900                 905                 910         


Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val 
        915                 920                 925             


Ala Arg Met Leu Asp Glu Arg Phe Asn Lys Glu Phe Asp Asp Asn Asn 
    930                 935                 940                 


Lys Arg Ile Cys Lys Val Lys Ile Val Thr Leu Lys Ser Asn Leu Val 
945                 950                 955                 960 


Ser Ser Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg Glu Ile Asn 
                965                 970                 975     


Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val Val Lys 
            980                 985                 990         


Ala Leu Leu Val Lys Tyr Ser Lys  Leu Glu Pro Glu Phe  Val Tyr Gly 
        995                 1000                 1005             


Glu Tyr  Pro Lys Tyr Asn Ser  Tyr Arg Glu Arg Lys  Thr Ala Thr 
    1010                 1015                 1020             


Gln Lys  Met Phe Phe Tyr Ser  Asn Ile Met Asn Met  Phe Lys Ser 
    1025                 1030                 1035             


Lys Val  Lys Leu Ala Asp Asp  Gln Ile Val Glu Arg  Pro Met Ile 
    1040                 1045                 1050             


Glu Val  Asn Asp Glu Thr Gly  Glu Ile Ala Trp Asp  Lys Thr Lys 
    1055                 1060                 1065             


His Ile  Thr Thr Val Lys Lys  Val Leu Ser Tyr Pro  Gln Val Asn 
    1070                 1075                 1080             


Ile Val  Lys Lys Val Glu Glu  Gln Thr Ile Gly Gln  Asn Gly Gly 
    1085                 1090                 1095             


Leu Phe  Asp Asp Asn Pro Lys  Ser Pro Leu Glu Val  Ile Pro Ser 
    1100                 1105                 1110             


Lys Leu  Val Pro Leu Lys Lys  Ala Leu Asn Pro Glu  Lys Tyr Gly 
    1115                 1120                 1125             


Gly Tyr  Gln Lys Pro Thr Thr  Ala Tyr Pro Ile Leu  Leu Ile Val 
    1130                 1135                 1140             


Asp Thr  Lys Gln Leu Ile Pro  Ile Ser Val Met Asp  Lys Lys Arg 
    1145                 1150                 1155             


Phe Glu  Gln Asn Pro Val Lys  Phe Leu Lys Asp Lys  Gly Tyr Gln 
    1160                 1165                 1170             


Gln Ile  Glu Lys Asn Asn Phe  Val Lys Leu Pro Lys  Tyr Thr Leu 
    1175                 1180                 1185             


Val Asp  Ile Gly Asn Gly Ile  Lys Arg Leu Trp Ala  Ser Ser Lys 
    1190                 1195                 1200             


Glu Val  His Lys Gly Asn Gln  Leu Val Val Ser Lys  Lys Ser Gln 
    1205                 1210                 1215             


Asp Leu  Leu Tyr His Ala His  His Leu Asp Asn Asp  Tyr Ser Asn 
    1220                 1225                 1230             


Glu Tyr  Val Lys Asn His Tyr  Gln Gln Phe Asp Ile  Leu Phe Asn 
    1235                 1240                 1245             


Glu Ile  Thr Ser Phe Ser Lys  Lys Cys Lys Leu Gly  Lys Glu His 
    1250                 1255                 1260             


Ile Gln  Lys Ile Glu Glu Ala  Tyr Ser Lys Glu Arg  Asp Ser Ala 
    1265                 1270                 1275             


Ser Ile  Glu Glu Leu Ala Asp  Gly Phe Ile Lys Leu  Leu Gly Phe 
    1280                 1285                 1290             


Thr Gln  Leu Gly Ala Thr Ser  Pro Phe Ser Phe Leu  Gly Ile Lys 
    1295                 1300                 1305             


Leu Asn  Gln Lys Gln Tyr Thr  Gly Lys Lys Asp Tyr  Leu Leu Pro 
    1310                 1315                 1320             


Cys Met  Glu Ala Thr Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr 
    1325                 1330                 1335             


Glu Thr  Arg Ile Asp Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345                 1350 


<210> 479
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 2VS1

<400> 479
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu His Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 480
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 2VS1

<400> 480
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu His Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 481
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 3SN1

<400> 481
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Lys Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 482
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 3SN1

<400> 482
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Lys Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 483
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 4SM1

<400> 483
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Thr Leu Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Pro Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Glu  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 484
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 4SM1

<400> 484
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Thr Leu Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Pro Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Glu  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 485
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 4VF1

<400> 485
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Lys Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Arg Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 486
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 4VF1

<400> 486
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Lys Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Arg Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 487
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 5SM3

<400> 487
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Phe Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ser Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Glu Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Pro Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Glu  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 488
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 5SM3

<400> 488
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Phe Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ser Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Glu Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Pro Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Glu  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 489
<211> 1359
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 66-2A

<400> 489
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Met Gln Val Asp Glu Ser 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Arg Tyr Pro Ile Phe Gly Thr Leu Lys Glu Glu Lys Lys Tyr 
        115                 120                 125             


His Lys Glu Phe Lys Thr Ile Tyr His Leu Arg Glu Lys Leu Ala Asn 
    130                 135                 140                 


Ser Thr Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ser Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Gln Leu Lys Ala 
                165                 170                 175     


Glu Asn Thr Asn Val Gln Ala Leu Phe Lys Asp Phe Val Glu Val Tyr 
            180                 185                 190         


Asp Lys Thr Val Glu Glu Ser His Leu Ser Glu Met Thr Val Asp Ala 
        195                 200                 205             


Leu Ser Ile Leu Thr Glu Lys Val Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Val Glu Cys Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Gln Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Gly Leu Leu Gly Glu Ile Gly Asp Glu Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ala Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Ala Val Asp Asp Asn Thr Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Lys Glu His Lys Glu Glu Leu Ala Ala Phe Lys 
                325                 330                 335     


Arg Phe Ile Lys Glu Lys Leu Pro Lys Lys Tyr Glu Glu Ile Phe Lys 
            340                 345                 350         


Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Val Gly Ala Asp Lys Lys 
        355                 360                 365             


Leu Arg Lys Arg Ser Gly Lys Leu Ala Thr Glu Glu Glu Phe Tyr Lys 
    370                 375                 380                 


Tyr Val Lys Gly Ile Leu Asn Lys Val Glu Gly Ala Asp Val Trp Leu 
385                 390                 395                 400 


Asp Lys Ile Asp Arg Glu Asp Phe Leu Arg Lys Gln Arg Thr Phe Asp 
                405                 410                 415     


Asn Gly Ser Ile Pro His Gln Ile His Leu Gln Glu Met His Ala Ile 
            420                 425                 430         


Leu Arg Arg Gln Gly Glu His Tyr Pro Phe Leu Lys Glu Asn Gln Asp 
        435                 440                 445             


Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro 
    450                 455                 460                 


Leu Val Arg Lys Gly Ser Arg Phe Ala Trp Ala Glu Tyr Lys Ala Asp 
465                 470                 475                 480 


Glu Lys Ile Thr Pro Trp Asn Phe Asp Asp Ile Leu Asp Lys Glu Lys 
                485                 490                 495     


Ser Ala Glu Lys Phe Ile Thr Arg Met Thr Leu Asn Asp Leu Tyr Leu 
            500                 505                 510         


Pro Glu Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Thr Phe 
        515                 520                 525             


Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Asn Glu Gln Gly 
    530                 535                 540                 


Glu Ala Lys Phe Phe Asp Ala Asn Met Lys Gln Glu Ile Phe Asp His 
545                 550                 555                 560 


Val Phe Lys Glu Asn Arg Lys Val Thr Lys Asp Lys Leu Leu Asn Tyr 
                565                 570                 575     


Leu Asn Lys Glu Phe Glu Glu Phe Arg Ile Val Asn Leu Thr Gly Leu 
            580                 585                 590         


Asp Lys Glu Asn Lys Val Phe Asn Ser Ser Leu Gly Thr Tyr His Asp 
        595                 600                 605             


Leu Arg Lys Ile Leu Asn Lys Ser Phe Leu Asp Asn Lys Glu Asn Glu 
    610                 615                 620                 


Gln Ile Ile Glu Asp Ile Ile Gln Thr Leu Thr Leu Phe Glu Asp Arg 
625                 630                 635                 640 


Glu Met Ile Arg Gln Arg Leu Gln Lys Tyr Ser Asp Ile Phe Thr Lys 
                645                 650                 655     


Ala Gln Leu Lys Lys Leu Glu Arg Arg His Tyr Thr Gly Trp Gly Arg 
            660                 665                 670         


Leu Ser Tyr Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Asn Lys 
        675                 680                 685             


Thr Ile Leu Gly Tyr Leu Ile Asp Asp Gly Tyr Ser Asn Arg Asn Phe 
    690                 695                 700                 


Met Gln Leu Ile Asn Asp Asp Ala Leu Ser Phe Lys Glu Glu Ile Ala 
705                 710                 715                 720 


Lys Ala Gln Val Ile Gly Glu Met Asp Gly Leu Asn Gln Val Val Ser 
                725                 730                 735     


Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Ser Leu 
            740                 745                 750         


Lys Ile Val Asp Glu Leu Val Lys Val Met Gly His Asn Pro Ala Asn 
        755                 760                 765             


Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Ala Lys Gly Arg 
    770                 775                 780                 


Arg Ser Ser Gln Lys Arg Tyr Lys Arg Leu Glu Glu Ala Ile Lys Asn 
785                 790                 795                 800 


Leu Asp His Asp Leu Asn His Lys Ile Leu Lys Glu His Pro Thr Asp 
                805                 810                 815     


Asn Gln Ala Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu Gln Asn 
            820                 825                 830         


Gly Arg Asp Met Tyr Thr Glu Asp Pro Leu Asp Ile Asn Arg Leu Ser 
        835                 840                 845             


Asp Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys Asp Asn 
    850                 855                 860                 


Ser Ile Asp Asn Arg Val Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys 
865                 870                 875                 880 


Ser Asp Asp Val Pro Ser Glu Glu Val Val His Lys Met Lys Pro Phe 
                885                 890                 895     


Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp 
            900                 905                 910         


Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp Lys Ala 
        915                 920                 925             


Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His 
    930                 935                 940                 


Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp Glu Asn 
945                 950                 955                 960 


Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser Asn Leu 
                965                 970                 975     


Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg Glu Ile 
            980                 985                 990         


Asn Asp Tyr His His Ala His Asp  Ala Tyr Leu Asn Ala  Val Ile Gly 
        995                 1000                 1005             


Lys Ala  Leu Leu Gly Val Tyr  Pro Gln Leu Glu Pro  Glu Phe Val 
    1010                 1015                 1020             


Tyr Gly  Asp Tyr Pro His Phe  His Gly His Lys Glu  Asn Lys Ala 
    1025                 1030                 1035             


Thr Ala  Lys Lys Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1040                 1045                 1050             


Lys Gly  Asp Val Arg Thr Asp  Lys Asn Gly Glu Ile  Ile Trp Lys 
    1055                 1060                 1065             


Lys Asp  Glu His Ile Ser Asn  Ile Lys Lys Val Leu  Ser Tyr Pro 
    1070                 1075                 1080             


Gln Val  Asn Ile Val Lys Lys  Val Glu Glu Gln Thr  Gly Gly Phe 
    1085                 1090                 1095             


Ser Lys  Glu Ser Ile Leu Pro  Lys Gly Asn Ser Asp  Lys Leu Ile 
    1100                 1105                 1110             


Pro Arg  Lys Thr Lys Lys Phe  Tyr Trp Asp Thr Lys  Lys Tyr Gly 
    1115                 1120                 1125             


Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser Ile Leu  Val Ile Ala 
    1130                 1135                 1140             


Asp Ile  Glu Lys Gly Lys Ser  Lys Lys Leu Lys Thr  Val Lys Ala 
    1145                 1150                 1155             


Leu Val  Gly Val Thr Ile Met  Glu Lys Met Thr Phe  Glu Arg Asp 
    1160                 1165                 1170             


Pro Val  Ala Phe Leu Glu Arg  Lys Gly Tyr Arg Asn  Val Gln Glu 
    1175                 1180                 1185             


Glu Asn  Ile Ile Lys Leu Pro  Lys Tyr Ser Leu Phe  Lys Leu Glu 
    1190                 1195                 1200             


Asn Gly  Arg Lys Arg Leu Leu  Ala Ser Ala Arg Glu  Leu Gln Lys 
    1205                 1210                 1215             


Gly Asn  Glu Ile Val Leu Pro  Asn His Leu Glu Thr  Leu Leu Tyr 
    1220                 1225                 1230             


His Ala  Lys Asn Ile His Lys  Val Asp Glu Pro Lys  His Leu Asp 
    1235                 1240                 1245             


Tyr Val  Asp Lys His Lys Asp  Glu Phe Lys Glu Leu  Leu Asp Val 
    1250                 1255                 1260             


Val Ser  Asn Phe Ser Lys Lys  Tyr Thr Leu Ala Glu  Gly Asn Leu 
    1265                 1270                 1275             


Glu Lys  Ile Lys Glu Leu Tyr  Ala Gln Asn Asn Gly  Glu Asp Leu 
    1280                 1285                 1290             


Lys Glu  Leu Ala Ser Ser Phe  Ile Asn Leu Leu Thr  Phe Thr Ala 
    1295                 1300                 1305             


Ile Gly  Ala Pro Ala Ala Phe  Lys Phe Phe Asp Lys  Asn Ile Asp 
    1310                 1315                 1320             


Arg Lys  Arg Tyr Thr Ser Thr  Thr Glu Ile Leu Asn  Ala Thr Leu 
    1325                 1330                 1335             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1340                 1345                 1350             


Asn Lys  Leu Gly Gly Asp 
    1355                 


<210> 490
<211> 1359
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 66-2A

<400> 490
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Met Gln Val Asp Glu Ser 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Arg Tyr Pro Ile Phe Gly Thr Leu Lys Glu Glu Lys Lys Tyr 
        115                 120                 125             


His Lys Glu Phe Lys Thr Ile Tyr His Leu Arg Glu Lys Leu Ala Asn 
    130                 135                 140                 


Ser Thr Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ser Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Gln Leu Lys Ala 
                165                 170                 175     


Glu Asn Thr Asn Val Gln Ala Leu Phe Lys Asp Phe Val Glu Val Tyr 
            180                 185                 190         


Asp Lys Thr Val Glu Glu Ser His Leu Ser Glu Met Thr Val Asp Ala 
        195                 200                 205             


Leu Ser Ile Leu Thr Glu Lys Val Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Val Glu Cys Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Gln Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Gly Leu Leu Gly Glu Ile Gly Asp Glu Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ala Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Ala Val Asp Asp Asn Thr Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Lys Arg Tyr Lys Glu His Lys Glu Glu Leu Ala Ala Phe Lys 
                325                 330                 335     


Arg Phe Ile Lys Glu Lys Leu Pro Lys Lys Tyr Glu Glu Ile Phe Lys 
            340                 345                 350         


Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Val Gly Ala Asp Lys Lys 
        355                 360                 365             


Leu Arg Lys Arg Ser Gly Lys Leu Ala Thr Glu Glu Glu Phe Tyr Lys 
    370                 375                 380                 


Tyr Val Lys Gly Ile Leu Asn Lys Val Glu Gly Ala Asp Val Trp Leu 
385                 390                 395                 400 


Asp Lys Ile Asp Arg Glu Asp Phe Leu Arg Lys Gln Arg Thr Phe Asp 
                405                 410                 415     


Asn Gly Ser Ile Pro His Gln Ile His Leu Gln Glu Met His Ala Ile 
            420                 425                 430         


Leu Arg Arg Gln Gly Glu His Tyr Pro Phe Leu Lys Glu Asn Gln Asp 
        435                 440                 445             


Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro 
    450                 455                 460                 


Leu Val Arg Lys Gly Ser Arg Phe Ala Trp Ala Glu Tyr Lys Ala Asp 
465                 470                 475                 480 


Glu Lys Ile Thr Pro Trp Asn Phe Asp Asp Ile Leu Asp Lys Glu Lys 
                485                 490                 495     


Ser Ala Glu Lys Phe Ile Thr Arg Met Thr Leu Asn Asp Leu Tyr Leu 
            500                 505                 510         


Pro Glu Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Thr Phe 
        515                 520                 525             


Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Asn Glu Gln Gly 
    530                 535                 540                 


Glu Ala Lys Phe Phe Asp Ala Asn Met Lys Gln Glu Ile Phe Asp His 
545                 550                 555                 560 


Val Phe Lys Glu Asn Arg Lys Val Thr Lys Asp Lys Leu Leu Asn Tyr 
                565                 570                 575     


Leu Asn Lys Glu Phe Glu Glu Phe Arg Ile Val Asn Leu Thr Gly Leu 
            580                 585                 590         


Asp Lys Glu Asn Lys Val Phe Asn Ser Ser Leu Gly Thr Tyr His Asp 
        595                 600                 605             


Leu Arg Lys Ile Leu Asn Lys Ser Phe Leu Asp Asn Lys Glu Asn Glu 
    610                 615                 620                 


Gln Ile Ile Glu Asp Ile Ile Gln Thr Leu Thr Leu Phe Glu Asp Arg 
625                 630                 635                 640 


Glu Met Ile Arg Gln Arg Leu Gln Lys Tyr Ser Asp Ile Phe Thr Lys 
                645                 650                 655     


Ala Gln Leu Lys Lys Leu Glu Arg Arg His Tyr Thr Gly Trp Gly Arg 
            660                 665                 670         


Leu Ser Tyr Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Asn Lys 
        675                 680                 685             


Thr Ile Leu Gly Tyr Leu Ile Asp Asp Gly Tyr Ser Asn Arg Asn Phe 
    690                 695                 700                 


Met Gln Leu Ile Asn Asp Asp Ala Leu Ser Phe Lys Glu Glu Ile Ala 
705                 710                 715                 720 


Lys Ala Gln Val Ile Gly Glu Met Asp Gly Leu Asn Gln Val Val Ser 
                725                 730                 735     


Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Ser Leu 
            740                 745                 750         


Lys Ile Val Asp Glu Leu Val Lys Val Met Gly His Asn Pro Ala Asn 
        755                 760                 765             


Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Ala Lys Gly Arg 
    770                 775                 780                 


Arg Ser Ser Gln Lys Arg Tyr Lys Arg Leu Glu Glu Ala Ile Lys Asn 
785                 790                 795                 800 


Leu Asp His Asp Leu Asn His Lys Ile Leu Lys Glu His Pro Thr Asp 
                805                 810                 815     


Asn Gln Ala Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu Gln Asn 
            820                 825                 830         


Gly Arg Asp Met Tyr Thr Glu Asp Pro Leu Asp Ile Asn Arg Leu Ser 
        835                 840                 845             


Asp Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys Asp Asn 
    850                 855                 860                 


Ser Ile Asp Asn Arg Val Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys 
865                 870                 875                 880 


Ser Asp Asp Val Pro Ser Glu Glu Val Val His Lys Met Lys Pro Phe 
                885                 890                 895     


Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp 
            900                 905                 910         


Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp Lys Ala 
        915                 920                 925             


Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His 
    930                 935                 940                 


Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp Glu Asn 
945                 950                 955                 960 


Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser Asn Leu 
                965                 970                 975     


Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg Glu Ile 
            980                 985                 990         


Asn Asp Tyr His His Ala His Asp  Ala Tyr Leu Asn Ala  Val Ile Gly 
        995                 1000                 1005             


Lys Ala  Leu Leu Gly Val Tyr  Pro Gln Leu Glu Pro  Glu Phe Val 
    1010                 1015                 1020             


Tyr Gly  Asp Tyr Pro His Phe  His Gly His Lys Glu  Asn Lys Ala 
    1025                 1030                 1035             


Thr Ala  Lys Lys Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1040                 1045                 1050             


Lys Gly  Asp Val Arg Thr Asp  Lys Asn Gly Glu Ile  Ile Trp Lys 
    1055                 1060                 1065             


Lys Asp  Glu His Ile Ser Asn  Ile Lys Lys Val Leu  Ser Tyr Pro 
    1070                 1075                 1080             


Gln Val  Asn Ile Val Lys Lys  Val Glu Glu Gln Thr  Gly Gly Phe 
    1085                 1090                 1095             


Ser Lys  Glu Ser Ile Leu Pro  Lys Gly Asn Ser Asp  Lys Leu Ile 
    1100                 1105                 1110             


Pro Arg  Lys Thr Lys Lys Phe  Tyr Trp Asp Thr Lys  Lys Tyr Gly 
    1115                 1120                 1125             


Gly Phe  Asp Ser Pro Ile Val  Ala Tyr Ser Ile Leu  Val Ile Ala 
    1130                 1135                 1140             


Asp Ile  Glu Lys Gly Lys Ser  Lys Lys Leu Lys Thr  Val Lys Ala 
    1145                 1150                 1155             


Leu Val  Gly Val Thr Ile Met  Glu Lys Met Thr Phe  Glu Arg Asp 
    1160                 1165                 1170             


Pro Val  Ala Phe Leu Glu Arg  Lys Gly Tyr Arg Asn  Val Gln Glu 
    1175                 1180                 1185             


Glu Asn  Ile Ile Lys Leu Pro  Lys Tyr Ser Leu Phe  Lys Leu Glu 
    1190                 1195                 1200             


Asn Gly  Arg Lys Arg Leu Leu  Ala Ser Ala Arg Glu  Leu Gln Lys 
    1205                 1210                 1215             


Gly Asn  Glu Ile Val Leu Pro  Asn His Leu Glu Thr  Leu Leu Tyr 
    1220                 1225                 1230             


His Ala  Lys Asn Ile His Lys  Val Asp Glu Pro Lys  His Leu Asp 
    1235                 1240                 1245             


Tyr Val  Asp Lys His Lys Asp  Glu Phe Lys Glu Leu  Leu Asp Val 
    1250                 1255                 1260             


Val Ser  Asn Phe Ser Lys Lys  Tyr Thr Leu Ala Glu  Gly Asn Leu 
    1265                 1270                 1275             


Glu Lys  Ile Lys Glu Leu Tyr  Ala Gln Asn Asn Gly  Glu Asp Leu 
    1280                 1285                 1290             


Lys Glu  Leu Ala Ser Ser Phe  Ile Asn Leu Leu Thr  Phe Thr Ala 
    1295                 1300                 1305             


Ile Gly  Ala Pro Ala Ala Phe  Lys Phe Phe Asp Lys  Asn Ile Asp 
    1310                 1315                 1320             


Arg Lys  Arg Tyr Thr Ser Thr  Thr Glu Ile Leu Asn  Ala Thr Leu 
    1325                 1330                 1335             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1340                 1345                 1350             


Asn Lys  Leu Gly Gly Asp 
    1355                 


<210> 491
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 8ID3

<400> 491
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Gly Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Leu Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Ile Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Asn  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 492
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans 8ID3

<400> 492
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Gly Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Leu Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Ile Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Asn  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 493
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans A19

<400> 493
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Gly Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Leu Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Ile  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 494
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans A19

<400> 494
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ser Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Gly Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Leu Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Ile  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 495
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans B

<400> 495
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu His Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 496
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans G123

<400> 496
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu His Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 497
<211> 1345
<212> PRT
<213> Streptococcus mutans

<400> 497
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Asp Glu Ser Phe Leu Thr Asp Asp Asp Lys Asn 
            100                 105                 110         


Phe Asp Ser His Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala Tyr 
        115                 120                 125             


His Gln Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ser Thr Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Lys Leu Phe Ala Asp Phe Val Gly Val Tyr 
            180                 185                 190         


Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Ser Ser Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu Lys 
    210                 215                 220                 


Leu Ile Asn Asn Tyr Pro Lys Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Gly Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu Tyr Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asp Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 498
<211> 1345
<212> PRT
<213> Streptococcus mutans

<400> 498
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Asp Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Ile Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 499
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans M21

<400> 499
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Ile Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 500
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans M21

<400> 500
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Ile Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 501
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans M230

<400> 501
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Gln Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Glu Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 502
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans M230

<400> 502
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Gln Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Glu Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 503
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans M2A

<400> 503
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Ile Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Tyr Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Ala  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 504
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans M2A

<400> 504
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Ile Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Tyr Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Ala  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 505
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans N29

<400> 505
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ser Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Ala  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 506
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans N29

<400> 506
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ser Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Ala  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 507
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans N3209

<400> 507
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Thr Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Cys Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Thr Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Leu Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Ser Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 508
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans N3209

<400> 508
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Thr Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Cys Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Thr Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Leu Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Ser Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 509
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans N66

<400> 509
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Ile Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Leu Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Gly Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu Tyr Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Phe  Lys Glu Ser Ile Leu  Pro Lys Gly Asp Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 510
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans N66

<400> 510
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Ile Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Leu Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Gly Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu Tyr Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Phe  Lys Glu Ser Ile Leu  Pro Lys Gly Asp Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 511
<211> 1350
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans NFSM1

<400> 511
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Thr Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Thr Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Glu Asp Val Val Asn Arg Met Arg 
865                 870                 875                 880 


Pro Phe Trp Asn Lys Leu Leu Ser Ser Gly Leu Ile Ser Gln Arg Lys 
                885                 890                 895     


Tyr Asn Asn Leu Thr Lys Lys Glu Leu Thr Pro Asp Asp Lys Ala Gly 
            900                 905                 910         


Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val 
        915                 920                 925             


Ala Arg Met Leu Asp Glu Arg Phe Asn Lys Glu Phe Asp Asp Asn Asn 
    930                 935                 940                 


Lys Arg Ile Arg Arg Val Lys Ile Val Thr Leu Lys Ser Asn Leu Val 
945                 950                 955                 960 


Ser Ser Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg Glu Ile Asn 
                965                 970                 975     


Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val Val Lys 
            980                 985                 990         


Ala Leu Leu Val Lys Tyr Pro Lys  Leu Glu Pro Glu Phe  Val Tyr Gly 
        995                 1000                 1005             


Glu Tyr  Pro Lys Tyr Asn Ser  Tyr Arg Glu Arg Lys  Thr Ala Thr 
    1010                 1015                 1020             


Gln Lys  Met Phe Phe Tyr Ser  Asn Ile Met Asn Met  Phe Lys Ser 
    1025                 1030                 1035             


Lys Val  Lys Leu Ala Asp Asp  Gln Ile Val Glu Arg  Pro Met Ile 
    1040                 1045                 1050             


Glu Val  Asn Asp Glu Thr Gly  Glu Ile Ala Trp Asp  Lys Thr Lys 
    1055                 1060                 1065             


His Ile  Thr Thr Val Lys Lys  Val Leu Ser Tyr Pro  Gln Val Asn 
    1070                 1075                 1080             


Ile Val  Lys Lys Val Glu Glu  Gln Thr Ile Gly Gln  Asn Gly Gly 
    1085                 1090                 1095             


Leu Phe  Asp Asp Asn Pro Lys  Ser Pro Leu Glu Val  Ile Pro Ser 
    1100                 1105                 1110             


Lys Leu  Val Pro Leu Lys Lys  Ala Leu Asn Pro Glu  Lys Tyr Gly 
    1115                 1120                 1125             


Gly Tyr  Gln Lys Pro Thr Thr  Ala Tyr Pro Ile Leu  Leu Ile Val 
    1130                 1135                 1140             


Asp Thr  Lys Gln Leu Ile Pro  Ile Ser Val Met Asp  Lys Lys Arg 
    1145                 1150                 1155             


Phe Glu  Gln Asn Pro Val Lys  Phe Leu Lys Asp Lys  Gly Tyr Gln 
    1160                 1165                 1170             


Gln Ile  Glu Lys Asn Asn Phe  Val Lys Leu Pro Lys  Tyr Thr Leu 
    1175                 1180                 1185             


Val Asp  Ile Gly Asn Gly Ile  Lys Arg Leu Trp Ala  Ser Ser Lys 
    1190                 1195                 1200             


Glu Val  His Lys Gly Asn Gln  Leu Val Val Ser Lys  Lys Ser Gln 
    1205                 1210                 1215             


Asp Leu  Leu Tyr His Ala His  His Leu Asp Asn Asp  Tyr Ser Asn 
    1220                 1225                 1230             


Glu Tyr  Val Lys Asn His Tyr  Gln Gln Phe Asp Ile  Leu Phe Asn 
    1235                 1240                 1245             


Glu Ile  Thr Ser Phe Ser Lys  Lys Cys Lys Leu Gly  Lys Glu His 
    1250                 1255                 1260             


Ile Gln  Lys Ile Glu Glu Ala  Tyr Ser Lys Glu Arg  Asp Ser Ala 
    1265                 1270                 1275             


Ser Ile  Glu Glu Leu Ala Asp  Gly Phe Ile Lys Leu  Leu Gly Phe 
    1280                 1285                 1290             


Thr Gln  Leu Gly Ala Thr Ser  Pro Phe Ser Phe Leu  Gly Ile Lys 
    1295                 1300                 1305             


Leu Asn  Gln Lys Gln Tyr Thr  Gly Lys Lys Asp Tyr  Leu Leu Pro 
    1310                 1315                 1320             


Cys Met  Glu Ala Thr Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr 
    1325                 1330                 1335             


Glu Thr  Arg Ile Asp Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345                 1350 


<210> 512
<211> 1350
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans NFSM1

<400> 512
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Thr Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Thr Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Glu Asp Val Val Asn Arg Met Arg 
865                 870                 875                 880 


Pro Phe Trp Asn Lys Leu Leu Ser Ser Gly Leu Ile Ser Gln Arg Lys 
                885                 890                 895     


Tyr Asn Asn Leu Thr Lys Lys Glu Leu Thr Pro Asp Asp Lys Ala Gly 
            900                 905                 910         


Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val 
        915                 920                 925             


Ala Arg Met Leu Asp Glu Arg Phe Asn Lys Glu Phe Asp Asp Asn Asn 
    930                 935                 940                 


Lys Arg Ile Arg Arg Val Lys Ile Val Thr Leu Lys Ser Asn Leu Val 
945                 950                 955                 960 


Ser Ser Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg Glu Ile Asn 
                965                 970                 975     


Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val Val Lys 
            980                 985                 990         


Ala Leu Leu Val Lys Tyr Pro Lys  Leu Glu Pro Glu Phe  Val Tyr Gly 
        995                 1000                 1005             


Glu Tyr  Pro Lys Tyr Asn Ser  Tyr Arg Glu Arg Lys  Thr Ala Thr 
    1010                 1015                 1020             


Gln Lys  Met Phe Phe Tyr Ser  Asn Ile Met Asn Met  Phe Lys Ser 
    1025                 1030                 1035             


Lys Val  Lys Leu Ala Asp Asp  Gln Ile Val Glu Arg  Pro Met Ile 
    1040                 1045                 1050             


Glu Val  Asn Asp Glu Thr Gly  Glu Ile Ala Trp Asp  Lys Thr Lys 
    1055                 1060                 1065             


His Ile  Thr Thr Val Lys Lys  Val Leu Ser Tyr Pro  Gln Val Asn 
    1070                 1075                 1080             


Ile Val  Lys Lys Val Glu Glu  Gln Thr Ile Gly Gln  Asn Gly Gly 
    1085                 1090                 1095             


Leu Phe  Asp Asp Asn Pro Lys  Ser Pro Leu Glu Val  Ile Pro Ser 
    1100                 1105                 1110             


Lys Leu  Val Pro Leu Lys Lys  Ala Leu Asn Pro Glu  Lys Tyr Gly 
    1115                 1120                 1125             


Gly Tyr  Gln Lys Pro Thr Thr  Ala Tyr Pro Ile Leu  Leu Ile Val 
    1130                 1135                 1140             


Asp Thr  Lys Gln Leu Ile Pro  Ile Ser Val Met Asp  Lys Lys Arg 
    1145                 1150                 1155             


Phe Glu  Gln Asn Pro Val Lys  Phe Leu Lys Asp Lys  Gly Tyr Gln 
    1160                 1165                 1170             


Gln Ile  Glu Lys Asn Asn Phe  Val Lys Leu Pro Lys  Tyr Thr Leu 
    1175                 1180                 1185             


Val Asp  Ile Gly Asn Gly Ile  Lys Arg Leu Trp Ala  Ser Ser Lys 
    1190                 1195                 1200             


Glu Val  His Lys Gly Asn Gln  Leu Val Val Ser Lys  Lys Ser Gln 
    1205                 1210                 1215             


Asp Leu  Leu Tyr His Ala His  His Leu Asp Asn Asp  Tyr Ser Asn 
    1220                 1225                 1230             


Glu Tyr  Val Lys Asn His Tyr  Gln Gln Phe Asp Ile  Leu Phe Asn 
    1235                 1240                 1245             


Glu Ile  Thr Ser Phe Ser Lys  Lys Cys Lys Leu Gly  Lys Glu His 
    1250                 1255                 1260             


Ile Gln  Lys Ile Glu Glu Ala  Tyr Ser Lys Glu Arg  Asp Ser Ala 
    1265                 1270                 1275             


Ser Ile  Glu Glu Leu Ala Asp  Gly Phe Ile Lys Leu  Leu Gly Phe 
    1280                 1285                 1290             


Thr Gln  Leu Gly Ala Thr Ser  Pro Phe Ser Phe Leu  Gly Ile Lys 
    1295                 1300                 1305             


Leu Asn  Gln Lys Gln Tyr Thr  Gly Lys Lys Asp Tyr  Leu Leu Pro 
    1310                 1315                 1320             


Cys Met  Glu Ala Thr Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr 
    1325                 1330                 1335             


Glu Thr  Arg Ile Asp Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345                 1350 


<210> 513
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans NLML1

<400> 513
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Lys Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Arg Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 514
<211> 1338
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans NLML4

<400> 514
Met Asp Leu Ile Gly Thr Asn Ser Val Gly Trp Ala Val Val Thr Asp 
1               5                   10                  15      


Asp Tyr Lys Val Pro Ala Lys Lys Met Lys Val Leu Gly Asn Thr Asp 
            20                  25                  30          


Lys Ser His Ile Lys Lys Asn Leu Leu Gly Ala Leu Leu Phe Asp Ser 
        35                  40                  45              


Gly Asn Thr Ala Ala Asp Arg Arg Leu Lys Arg Thr Ala Arg Arg Arg 
    50                  55                  60                  


Tyr Thr Arg Arg Arg Asn Arg Ile Leu Tyr Leu Gln Glu Ile Phe Ala 
65                  70                  75                  80  


Glu Glu Met Ser Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Asp 
                85                  90                  95      


Ser Phe Leu Val Thr Glu Asp Lys Arg Gly Glu Arg His Pro Ile Phe 
            100                 105                 110         


Gly Asn Leu Glu Glu Glu Val Lys Tyr His Glu Asn Phe Pro Thr Ile 
        115                 120                 125             


Tyr His Leu Arg Gln Tyr Leu Ala Asp Asn Pro Glu Lys Val Asp Leu 
    130                 135                 140                 


Arg Leu Val Tyr Leu Ala Leu Ala His Ile Ile Lys Phe Arg Gly His 
145                 150                 155                 160 


Phe Leu Ile Glu Gly Lys Phe Asp Thr Arg Asn Asn Asp Val Gln Arg 
                165                 170                 175     


Leu Phe Gln Glu Phe Leu Ala Val Tyr Asp Asn Thr Phe Glu Asn Ser 
            180                 185                 190         


Ser Leu Gln Glu Gln Asn Val Gln Val Glu Glu Ile Leu Thr Asp Lys 
        195                 200                 205             


Ile Ser Lys Ser Ala Lys Lys Asp Arg Val Leu Lys Leu Phe Pro Asn 
    210                 215                 220                 


Glu Lys Ser Asn Gly Arg Phe Ala Glu Phe Leu Lys Leu Ile Val Gly 
225                 230                 235                 240 


Asn Gln Ala Asp Phe Lys Lys His Phe Glu Leu Glu Glu Lys Ala Pro 
                245                 250                 255     


Leu Gln Phe Ser Lys Asp Thr Tyr Glu Glu Glu Leu Glu Val Leu Leu 
            260                 265                 270         


Ala Gln Ile Gly Asp Asn Tyr Ala Glu Leu Phe Leu Ser Ala Lys Lys 
        275                 280                 285             


Leu Tyr Asp Ser Ile Leu Leu Ser Gly Ile Leu Thr Val Thr Asp Val 
    290                 295                 300                 


Ser Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Gln Arg Tyr Asn Glu 
305                 310                 315                 320 


His Gln Met Asp Leu Ala Gln Leu Lys Gln Phe Ile Arg Gln Lys Leu 
                325                 330                 335     


Ser Asp Lys Tyr Asn Glu Val Phe Ser Asp Val Ser Lys Asp Gly Tyr 
            340                 345                 350         


Ala Gly Tyr Ile Asp Gly Lys Thr Asn Gln Glu Ala Phe Tyr Lys Tyr 
        355                 360                 365             


Leu Lys Gly Leu Leu Asn Lys Ile Glu Gly Ser Gly Tyr Phe Leu Asp 
    370                 375                 380                 


Lys Ile Glu Arg Glu Asp Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn 
385                 390                 395                 400 


Gly Ser Ile Pro His Gln Ile His Leu Gln Glu Met Arg Ala Ile Ile 
                405                 410                 415     


Arg Arg Gln Ala Glu Phe Tyr Pro Phe Leu Ala Asp Asn Gln Asp Arg 
            420                 425                 430         


Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu 
        435                 440                 445             


Ala Arg Gly Lys Ser Asp Phe Ala Trp Leu Ser Arg Lys Ser Ala Asp 
    450                 455                 460                 


Lys Ile Thr Pro Trp Asn Phe Asp Glu Ile Val Asp Lys Glu Ser Ser 
465                 470                 475                 480 


Ala Glu Ala Phe Ile Asn Arg Met Thr Asn Tyr Asp Leu Tyr Leu Pro 
                485                 490                 495     


Asn Gln Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys Phe Thr 
            500                 505                 510         


Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Lys Thr Glu Gln Gly Lys 
        515                 520                 525             


Thr Ala Phe Phe Asp Ala Asn Met Lys Gln Glu Ile Phe Asp Gly Val 
    530                 535                 540                 


Phe Lys Val Tyr Arg Lys Val Thr Lys Asp Lys Leu Met Asp Phe Leu 
545                 550                 555                 560 


Glu Lys Glu Phe Asp Glu Phe Arg Ile Val Asp Leu Thr Gly Leu Asp 
                565                 570                 575     


Lys Glu Asn Lys Ala Phe Asn Ala Ser Tyr Gly Thr Tyr His Asp Leu 
            580                 585                 590         


Arg Lys Ile Leu Asp Lys Asp Phe Leu Asp Asn Ser Lys Asn Glu Lys 
        595                 600                 605             


Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu 
    610                 615                 620                 


Met Ile Arg Lys Arg Leu Glu Asn Tyr Ser Asp Leu Leu Thr Lys Glu 
625                 630                 635                 640 


Gln Val Lys Lys Leu Glu Arg Arg His Tyr Thr Gly Trp Gly Arg Leu 
                645                 650                 655     


Ser Ala Glu Leu Ile His Gly Ile Arg Asn Lys Glu Ser Arg Lys Thr 
            660                 665                 670         


Ile Leu Asp Tyr Leu Ile Asp Asp Gly Asn Ser Asn Arg Asn Phe Met 
        675                 680                 685             


Gln Leu Ile Asn Asp Asp Ala Leu Ser Phe Lys Glu Glu Ile Ala Lys 
    690                 695                 700                 


Ala Gln Val Ile Gly Glu Thr Asp Asn Leu Asn Gln Val Val Ser Asp 
705                 710                 715                 720 


Ile Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys 
                725                 730                 735     


Ile Val Asp Glu Leu Val Lys Ile Met Gly His Gln Pro Glu Asn Ile 
            740                 745                 750         


Val Val Glu Met Ala Arg Glu Asn Gln Phe Thr Asn Gln Gly Arg Arg 
        755                 760                 765             


Asn Ser Gln Gln Arg Leu Lys Gly Leu Thr Asp Ser Ile Lys Glu Phe 
    770                 775                 780                 


Gly Ser Gln Ile Leu Lys Glu His Pro Val Glu His Ser Gln Leu Gln 
785                 790                 795                 800 


Asn Asp Arg Leu Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr 
                805                 810                 815     


Thr Gly Glu Glu Leu Asp Ile Asp Tyr Leu Ser Gln Tyr Asp Ile Asp 
            820                 825                 830         


His Ile Ile Pro Gln Ala Phe Ile Lys Asp Asn Ser Ile Asp Asn Arg 
        835                 840                 845             


Val Leu Thr Ser Ser Lys Glu Asn Arg Gly Lys Ser Asp Asp Val Pro 
    850                 855                 860                 


Ser Lys Asn Val Val Arg Lys Met Lys Ser Tyr Trp Ser Lys Leu Leu 
865                 870                 875                 880 


Ser Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala 
                885                 890                 895     


Glu Arg Gly Gly Leu Thr Asp Asp Asp Lys Ala Gly Phe Ile Lys Arg 
            900                 905                 910         


Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu 
        915                 920                 925             


Asp Glu Arg Phe His Thr Glu Thr Asp Glu Asn Asn Lys Lys Ile Arg 
    930                 935                 940                 


Gln Val Lys Ile Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg 
945                 950                 955                 960 


Lys Glu Phe Glu Leu Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His 
                965                 970                 975     


Ala His Asp Ala Tyr Leu Asn Ala Val Ile Gly Lys Ala Leu Leu Gly 
            980                 985                 990         


Val Tyr Pro Gln Leu Glu Pro Glu  Phe Val Tyr Gly Asp  Tyr Pro His 
        995                 1000                 1005             


Phe His  Gly His Lys Glu Asn  Lys Ala Thr Ala Lys  Lys Phe Phe 
    1010                 1015                 1020             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Lys Asp Asp  Val Arg Thr 
    1025                 1030                 1035             


Asp Lys  Asn Gly Glu Ile Ile  Trp Lys Lys Asp Glu  His Ile Ser 
    1040                 1045                 1050             


Asn Ile  Lys Lys Val Leu Ser  Tyr Pro Gln Val Asn  Ile Val Lys 
    1055                 1060                 1065             


Lys Val  Glu Glu Gln Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu 
    1070                 1075                 1080             


Pro Lys  Gly Asn Ser Asp Lys  Leu Ile Pro Arg Lys  Thr Lys Lys 
    1085                 1090                 1095             


Phe Tyr  Trp Asp Thr Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Ile 
    1100                 1105                 1110             


Val Ala  Tyr Ser Ile Leu Val  Ile Ala Asp Ile Glu  Lys Gly Lys 
    1115                 1120                 1125             


Ser Lys  Lys Leu Lys Thr Val  Lys Ala Leu Val Gly  Val Thr Ile 
    1130                 1135                 1140             


Met Glu  Lys Met Thr Phe Glu  Arg Asp Pro Val Ala  Phe Leu Glu 
    1145                 1150                 1155             


Arg Lys  Gly Tyr Arg Asn Val  Gln Glu Glu Asn Ile  Ile Lys Leu 
    1160                 1165                 1170             


Pro Lys  Tyr Ser Leu Phe Lys  Leu Glu Asn Gly Arg  Lys Arg Leu 
    1175                 1180                 1185             


Leu Ala  Ser Ala Arg Glu Leu  Gln Lys Gly Asn Glu  Ile Val Leu 
    1190                 1195                 1200             


Pro Asn  His Leu Gly Thr Leu  Leu Tyr His Ala Lys  Asn Ile His 
    1205                 1210                 1215             


Lys Val  Asp Glu Pro Lys His  Leu Asp Tyr Val Asp  Lys His Lys 
    1220                 1225                 1230             


Asp Glu  Phe Lys Glu Leu Leu  Asp Val Val Ser Asn  Phe Ser Lys 
    1235                 1240                 1245             


Lys Tyr  Thr Leu Ala Glu Gly  Asn Leu Glu Lys Ile  Lys Glu Leu 
    1250                 1255                 1260             


Tyr Ala  Gln Asn Asn Gly Glu  Asp Leu Lys Glu Leu  Ala Ser Ser 
    1265                 1270                 1275             


Phe Ile  Asn Leu Leu Thr Phe  Thr Ala Ile Gly Ala  Pro Ala Thr 
    1280                 1285                 1290             


Phe Lys  Phe Phe Asp Lys Asn  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1295                 1300                 1305             


Thr Thr  Glu Ile Leu Asn Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1310                 1315                 1320             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Lys Leu  Gly Gly Asp 
    1325                 1330                 1335             


<210> 515
<211> 1338
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans NLML4

<400> 515
Met Asp Leu Ile Gly Thr Asn Ser Val Gly Trp Ala Val Val Thr Asp 
1               5                   10                  15      


Asp Tyr Lys Val Pro Ala Lys Lys Met Lys Val Leu Gly Asn Thr Asp 
            20                  25                  30          


Lys Ser His Ile Lys Lys Asn Leu Leu Gly Ala Leu Leu Phe Asp Ser 
        35                  40                  45              


Gly Asn Thr Ala Ala Asp Arg Arg Leu Lys Arg Thr Ala Arg Arg Arg 
    50                  55                  60                  


Tyr Thr Arg Arg Arg Asn Arg Ile Leu Tyr Leu Gln Glu Ile Phe Ala 
65                  70                  75                  80  


Glu Glu Met Ser Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Asp 
                85                  90                  95      


Ser Phe Leu Val Thr Glu Asp Lys Arg Gly Glu Arg His Pro Ile Phe 
            100                 105                 110         


Gly Asn Leu Glu Glu Glu Val Lys Tyr His Glu Asn Phe Pro Thr Ile 
        115                 120                 125             


Tyr His Leu Arg Gln Tyr Leu Ala Asp Asn Pro Glu Lys Val Asp Leu 
    130                 135                 140                 


Arg Leu Val Tyr Leu Ala Leu Ala His Ile Ile Lys Phe Arg Gly His 
145                 150                 155                 160 


Phe Leu Ile Glu Gly Lys Phe Asp Thr Arg Asn Asn Asp Val Gln Arg 
                165                 170                 175     


Leu Phe Gln Glu Phe Leu Ala Val Tyr Asp Asn Thr Phe Glu Asn Ser 
            180                 185                 190         


Ser Leu Gln Glu Gln Asn Val Gln Val Glu Glu Ile Leu Thr Asp Lys 
        195                 200                 205             


Ile Ser Lys Ser Ala Lys Lys Asp Arg Val Leu Lys Leu Phe Pro Asn 
    210                 215                 220                 


Glu Lys Ser Asn Gly Arg Phe Ala Glu Phe Leu Lys Leu Ile Val Gly 
225                 230                 235                 240 


Asn Gln Ala Asp Phe Lys Lys His Phe Glu Leu Glu Glu Lys Ala Pro 
                245                 250                 255     


Leu Gln Phe Ser Lys Asp Thr Tyr Glu Glu Glu Leu Glu Val Leu Leu 
            260                 265                 270         


Ala Gln Ile Gly Asp Asn Tyr Ala Glu Leu Phe Leu Ser Ala Lys Lys 
        275                 280                 285             


Leu Tyr Asp Ser Ile Leu Leu Ser Gly Ile Leu Thr Val Thr Asp Val 
    290                 295                 300                 


Ser Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Gln Arg Tyr Asn Glu 
305                 310                 315                 320 


His Gln Met Asp Leu Ala Gln Leu Lys Gln Phe Ile Arg Gln Lys Leu 
                325                 330                 335     


Ser Asp Lys Tyr Asn Glu Val Phe Ser Asp Val Ser Lys Asp Gly Tyr 
            340                 345                 350         


Ala Gly Tyr Ile Asp Gly Lys Thr Asn Gln Glu Ala Phe Tyr Lys Tyr 
        355                 360                 365             


Leu Lys Gly Leu Leu Asn Lys Ile Glu Gly Ser Gly Tyr Phe Leu Asp 
    370                 375                 380                 


Lys Ile Glu Arg Glu Asp Phe Leu Arg Lys Gln Arg Thr Phe Asp Asn 
385                 390                 395                 400 


Gly Ser Ile Pro His Gln Ile His Leu Gln Glu Met Arg Ala Ile Ile 
                405                 410                 415     


Arg Arg Gln Ala Glu Phe Tyr Pro Phe Leu Ala Asp Asn Gln Asp Arg 
            420                 425                 430         


Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu 
        435                 440                 445             


Ala Arg Gly Lys Ser Asp Phe Ala Trp Leu Ser Arg Lys Ser Ala Asp 
    450                 455                 460                 


Lys Ile Thr Pro Trp Asn Phe Asp Glu Ile Val Asp Lys Glu Ser Ser 
465                 470                 475                 480 


Ala Glu Ala Phe Ile Asn Arg Met Thr Asn Tyr Asp Leu Tyr Leu Pro 
                485                 490                 495     


Asn Gln Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys Phe Thr 
            500                 505                 510         


Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Lys Thr Glu Gln Gly Lys 
        515                 520                 525             


Thr Ala Phe Phe Asp Ala Asn Met Lys Gln Glu Ile Phe Asp Gly Val 
    530                 535                 540                 


Phe Lys Val Tyr Arg Lys Val Thr Lys Asp Lys Leu Met Asp Phe Leu 
545                 550                 555                 560 


Glu Lys Glu Phe Asp Glu Phe Arg Ile Val Asp Leu Thr Gly Leu Asp 
                565                 570                 575     


Lys Glu Asn Lys Ala Phe Asn Ala Ser Tyr Gly Thr Tyr His Asp Leu 
            580                 585                 590         


Arg Lys Ile Leu Asp Lys Asp Phe Leu Asp Asn Ser Lys Asn Glu Lys 
        595                 600                 605             


Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu 
    610                 615                 620                 


Met Ile Arg Lys Arg Leu Glu Asn Tyr Ser Asp Leu Leu Thr Lys Glu 
625                 630                 635                 640 


Gln Val Lys Lys Leu Glu Arg Arg His Tyr Thr Gly Trp Gly Arg Leu 
                645                 650                 655     


Ser Ala Glu Leu Ile His Gly Ile Arg Asn Lys Glu Ser Arg Lys Thr 
            660                 665                 670         


Ile Leu Asp Tyr Leu Ile Asp Asp Gly Asn Ser Asn Arg Asn Phe Met 
        675                 680                 685             


Gln Leu Ile Asn Asp Asp Ala Leu Ser Phe Lys Glu Glu Ile Ala Lys 
    690                 695                 700                 


Ala Gln Val Ile Gly Glu Thr Asp Asn Leu Asn Gln Val Val Ser Asp 
705                 710                 715                 720 


Ile Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys 
                725                 730                 735     


Ile Val Asp Glu Leu Val Lys Ile Met Gly His Gln Pro Glu Asn Ile 
            740                 745                 750         


Val Val Glu Met Ala Arg Glu Asn Gln Phe Thr Asn Gln Gly Arg Arg 
        755                 760                 765             


Asn Ser Gln Gln Arg Leu Lys Gly Leu Thr Asp Ser Ile Lys Glu Phe 
    770                 775                 780                 


Gly Ser Gln Ile Leu Lys Glu His Pro Val Glu His Ser Gln Leu Gln 
785                 790                 795                 800 


Asn Asp Arg Leu Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr 
                805                 810                 815     


Thr Gly Glu Glu Leu Asp Ile Asp Tyr Leu Ser Gln Tyr Asp Ile Asp 
            820                 825                 830         


His Ile Ile Pro Gln Ala Phe Ile Lys Asp Asn Ser Ile Asp Asn Arg 
        835                 840                 845             


Val Leu Thr Ser Ser Lys Glu Asn Arg Gly Lys Ser Asp Asp Val Pro 
    850                 855                 860                 


Ser Lys Asn Val Val Arg Lys Met Lys Ser Tyr Trp Ser Lys Leu Leu 
865                 870                 875                 880 


Ser Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala 
                885                 890                 895     


Glu Arg Gly Gly Leu Thr Asp Asp Asp Lys Ala Gly Phe Ile Lys Arg 
            900                 905                 910         


Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu 
        915                 920                 925             


Asp Glu Arg Phe His Thr Glu Thr Asp Glu Asn Asn Lys Lys Ile Arg 
    930                 935                 940                 


Gln Val Lys Ile Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg 
945                 950                 955                 960 


Lys Glu Phe Glu Leu Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His 
                965                 970                 975     


Ala His Asp Ala Tyr Leu Asn Ala Val Ile Gly Lys Ala Leu Leu Gly 
            980                 985                 990         


Val Tyr Pro Gln Leu Glu Pro Glu  Phe Val Tyr Gly Asp  Tyr Pro His 
        995                 1000                 1005             


Phe His  Gly His Lys Glu Asn  Lys Ala Thr Ala Lys  Lys Phe Phe 
    1010                 1015                 1020             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Lys Asp Asp  Val Arg Thr 
    1025                 1030                 1035             


Asp Lys  Asn Gly Glu Ile Ile  Trp Lys Lys Asp Glu  His Ile Ser 
    1040                 1045                 1050             


Asn Ile  Lys Lys Val Leu Ser  Tyr Pro Gln Val Asn  Ile Val Lys 
    1055                 1060                 1065             


Lys Val  Glu Glu Gln Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu 
    1070                 1075                 1080             


Pro Lys  Gly Asn Ser Asp Lys  Leu Ile Pro Arg Lys  Thr Lys Lys 
    1085                 1090                 1095             


Phe Tyr  Trp Asp Thr Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Ile 
    1100                 1105                 1110             


Val Ala  Tyr Ser Ile Leu Val  Ile Ala Asp Ile Glu  Lys Gly Lys 
    1115                 1120                 1125             


Ser Lys  Lys Leu Lys Thr Val  Lys Ala Leu Val Gly  Val Thr Ile 
    1130                 1135                 1140             


Met Glu  Lys Met Thr Phe Glu  Arg Asp Pro Val Ala  Phe Leu Glu 
    1145                 1150                 1155             


Arg Lys  Gly Tyr Arg Asn Val  Gln Glu Glu Asn Ile  Ile Lys Leu 
    1160                 1165                 1170             


Pro Lys  Tyr Ser Leu Phe Lys  Leu Glu Asn Gly Arg  Lys Arg Leu 
    1175                 1180                 1185             


Leu Ala  Ser Ala Arg Glu Leu  Gln Lys Gly Asn Glu  Ile Val Leu 
    1190                 1195                 1200             


Pro Asn  His Leu Gly Thr Leu  Leu Tyr His Ala Lys  Asn Ile His 
    1205                 1210                 1215             


Lys Val  Asp Glu Pro Lys His  Leu Asp Tyr Val Asp  Lys His Lys 
    1220                 1225                 1230             


Asp Glu  Phe Lys Glu Leu Leu  Asp Val Val Ser Asn  Phe Ser Lys 
    1235                 1240                 1245             


Lys Tyr  Thr Leu Ala Glu Gly  Asn Leu Glu Lys Ile  Lys Glu Leu 
    1250                 1255                 1260             


Tyr Ala  Gln Asn Asn Gly Glu  Asp Leu Lys Glu Leu  Ala Ser Ser 
    1265                 1270                 1275             


Phe Ile  Asn Leu Leu Thr Phe  Thr Ala Ile Gly Ala  Pro Ala Thr 
    1280                 1285                 1290             


Phe Lys  Phe Phe Asp Lys Asn  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1295                 1300                 1305             


Thr Thr  Glu Ile Leu Asn Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1310                 1315                 1320             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Lys Leu  Gly Gly Asp 
    1325                 1330                 1335             


<210> 516
<211> 1128
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans NLML5

<400> 516
Met Ala Asn Ser Lys Ile Leu Gly Leu Asp Ile Gly Ile Ala Ser Val 
1               5                   10                  15      


Gly Val Gly Ile Ile Asp Lys Glu Thr Gly Lys Ile Ile His Val Asn 
            20                  25                  30          


Ser Arg Ile Phe Pro Ala Ala Thr Ala Asp Ser Asn Val Glu Arg Arg 
        35                  40                  45              


Gly Phe Arg Gln Gly Arg Arg Leu Val Arg Arg Lys Lys His Arg Lys 
    50                  55                  60                  


Val Arg Leu Ala Asp Leu Phe Leu Asp Ser Asn Leu Leu Thr Asp Phe 
65                  70                  75                  80  


Ser Lys Val Ser Leu Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly 
                85                  90                  95      


Leu Asn Glu Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Ser 
            100                 105                 110         


Ile Val Ser Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Glu Asp 
        115                 120                 125             


Ser Gly Ala Asn Ser Ser Glu Tyr Gly Lys Ala Val Glu Glu Asn Arg 
    130                 135                 140                 


Lys Leu Leu Glu Asp Arg Thr Pro Gly Gln Ile Gln Leu Glu Arg Phe 
145                 150                 155                 160 


Glu Lys Tyr Gly Lys Val Arg Gly Asp Phe Thr Val Val Glu Asn Gly 
                165                 170                 175     


Glu Asn His Arg Leu Ile Asn Val Phe Ser Thr Ser Ala Tyr Lys Lys 
            180                 185                 190         


Glu Ala Glu Arg Ile Leu Arg Arg Gln Gln Glu Phe Asn Ile Arg Ile 
        195                 200                 205             


Ala Asp Glu Phe Ile Glu Ala Tyr Leu Thr Ile Leu Thr Gly Lys Arg 
    210                 215                 220                 


Lys Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly 
225                 230                 235                 240 


Arg Phe Arg Thr Asp Gly Thr Thr Leu Asp Asn Ile Phe Gly Ile Leu 
                245                 250                 255     


Ile Gly Lys Cys Thr Phe Tyr Pro Asp Glu Tyr Arg Ala Ala Lys Ala 
            260                 265                 270         


Ser Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu 
        275                 280                 285             


Thr Val Pro Thr Glu Thr Lys Lys Leu Ser Glu Glu Gln Lys Arg Gln 
    290                 295                 300                 


Ile Ile Glu His Ala Lys Thr Val Lys Thr Leu Gly Ala Pro Thr Leu 
305                 310                 315                 320 


Leu Lys Tyr Ile Ala Lys Leu Val Gly Cys Ser Ala Asp Asp Ile Lys 
                325                 330                 335     


Gly Tyr Arg Ile Asp Lys Ser Asp Lys Pro Glu Ile His Thr Phe Glu 
            340                 345                 350         


Ala Tyr Arg Lys Met Arg Thr Met Glu Leu Ile Lys Val Ala Asp Leu 
        355                 360                 365             


Ser Arg Glu Ser Leu Asp Ala Leu Ala His Ile Leu Thr Leu Asn Thr 
    370                 375                 380                 


Glu Arg Glu Gly Ile Glu Glu Ala Ile Arg Asp Arg Phe Thr Asn Lys 
385                 390                 395                 400 


Glu Phe Asn Gln Glu Gln Ile Asn Glu Leu Val Leu Phe Arg Lys Asn 
                405                 410                 415     


Asn Ser Ser Leu Phe Gly Lys Gly Trp His Asn Phe Ser Leu Lys Leu 
            420                 425                 430         


Met Lys Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met 
        435                 440                 445             


Thr Ile Leu Thr Arg Leu Gly Lys Gln Arg Val Lys Lys Ser Ser Asn 
    450                 455                 460                 


Arg Thr Asn Tyr Ile Asp Glu Lys Glu Leu Thr Glu Glu Ile Tyr Asn 
465                 470                 475                 480 


Pro Val Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Ile Asn Leu 
                485                 490                 495     


Ala Thr Lys Lys Tyr Gly Val Phe Asp Asn Ile Val Ile Glu Met Ala 
            500                 505                 510         


Arg Glu Ser Asn Glu Asp Asp Glu Lys Lys Ala Ile Gln Asn Ala Gln 
        515                 520                 525             


Lys Ala Asn Glu Asp Glu Lys Glu Ala Ala Leu Leu Lys Ala Ala His 
    530                 535                 540                 


Gln Phe Asn Gly Lys Glu Glu Leu Pro Asp Ser Ile Phe His Gly His 
545                 550                 555                 560 


Lys Glu Leu Leu Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Lys 
                565                 570                 575     


Cys Leu Tyr Thr Gly Lys Thr Ile Phe Ile Asn Asp Leu Ile His Asn 
            580                 585                 590         


Pro Tyr Lys Tyr Glu Ile Asp His Ile Leu Pro Leu Ser Leu Ser Phe 
        595                 600                 605             


Asp Asp Ser Leu Ala Asn Lys Val Leu Val Leu Ser Thr Ala Asn Gln 
    610                 615                 620                 


Glu Lys Gly Gln Arg Thr Pro Phe Gln Ser Leu Asp Ser Met Asp Gly 
625                 630                 635                 640 


Ala Trp Thr Tyr Arg Glu Phe Lys Ala Tyr Val Lys Gly Leu Lys Thr 
                645                 650                 655     


Leu Ser Asn Lys Lys Lys Asp Tyr Leu Leu Asn Glu Glu Asp Ile Asn 
            660                 665                 670         


Lys Asn Glu Val Lys Gln Lys Phe Ile Glu Arg Asn Leu Val Asp Thr 
        675                 680                 685             


Arg Tyr Ser Ser Arg Val Val Leu Asn Thr Leu Gln Asp Phe Tyr Lys 
    690                 695                 700                 


Lys Arg Glu Phe Asp Thr Lys Ile Ser Val Val Arg Gly Gln Phe Thr 
705                 710                 715                 720 


Ser Gln Ile Arg Arg Lys Trp Arg Ile Glu Lys Thr Arg Glu Thr Tyr 
                725                 730                 735     


His His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu 
            740                 745                 750         


Asn Leu Trp Lys Lys Gln Asn Asn Pro Leu Ile Ser Tyr Lys Glu Asp 
        755                 760                 765             


Gln Phe Val Asp Pro Glu Thr Gly Glu Ile Leu Ser Leu Ser Asp Asp 
    770                 775                 780                 


Glu Tyr Lys Glu Leu Val Phe Lys Ala Pro Tyr Asp His Phe Val Asp 
785                 790                 795                 800 


Thr Leu Lys Ser Lys Lys Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln 
                805                 810                 815     


Val Asp Ser Lys Tyr Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Gly 
            820                 825                 830         


Thr Arg Lys Ala Arg Leu Gly Lys Asp Ser Gln Glu Glu Thr Tyr Val 
        835                 840                 845             


Leu Gly Lys Ile Lys Asp Ile Tyr Ser Gln Lys Gly Tyr Glu Asp Phe 
    850                 855                 860                 


Ile Lys Lys Tyr Lys Lys Asp Lys Thr Gln Phe Leu Met Tyr His Lys 
865                 870                 875                 880 


Asp Pro Gln Thr Phe Glu Lys Val Ile Glu Glu Ile Leu Lys Thr Tyr 
                885                 890                 895     


Ser Asp Lys Glu Leu Asn Glu Lys Gly Lys Glu Val Pro Cys Asn Pro 
            900                 905                 910         


Phe Glu Lys Tyr Arg Gln Glu Asn Gly Pro Val Arg Lys Tyr Ser Lys 
        915                 920                 925             


Lys Gly Asn Gly Pro Glu Ile Lys Ser Ile Lys Tyr Tyr Asp Asn Lys 
    930                 935                 940                 


Leu Gly Asn His Ile Asp Ile Thr Pro Asn Asn Ser His His Gln Val 
945                 950                 955                 960 


Val Leu Gln Ser Leu Lys Pro Trp Arg Thr Asp Val Tyr Phe Asn Pro 
                965                 970                 975     


Lys Ser Gly Lys Tyr Glu Leu Met Gly Leu Lys Tyr Ser Asp Leu Arg 
            980                 985                 990         


Phe Glu Lys Val Ser Gly Asp Tyr  Gly Ile Ser Val Lys  Lys Tyr Asn 
        995                 1000                 1005             


Glu Ile  Lys Ser Lys Glu Gly  Val Asp Glu Asn Ser  Glu Phe Lys 
    1010                 1015                 1020             


Phe Thr  Leu Tyr Lys Asn Asp  Leu Ile Leu Ile Lys  Asp Thr Glu 
    1025                 1030                 1035             


Ser Gly  Glu Gln Glu Leu Phe  Arg Phe Leu Ser Arg  Thr Met Pro 
    1040                 1045                 1050             


Asn Gln  Lys His Tyr Val Glu  Leu Lys Pro Tyr Asp  Lys Ser Lys 
    1055                 1060                 1065             


Phe Glu  Gly His Gln Lys Leu  Met Asp Ile Phe Gly  Glu Val Ala 
    1070                 1075                 1080             


Lys Gly  Gly Gln Cys Leu Lys  Gly Leu Asn Lys Ser  Asn Ile Ser 
    1085                 1090                 1095             


Ile Tyr  Lys Val Lys Thr Asp  Val Leu Gly Asn Lys  Tyr Phe Ile 
    1100                 1105                 1110             


Lys Lys  Glu Gly Asp Gln Pro  Gln Leu Asn Phe Lys  Lys Lys Ile 
    1115                 1120                 1125             


<210> 517
<211> 1128
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans NLML5

<400> 517
Met Ala Asn Ser Lys Ile Leu Gly Leu Asp Ile Gly Ile Ala Ser Val 
1               5                   10                  15      


Gly Val Gly Ile Ile Asp Lys Glu Thr Gly Lys Ile Ile His Val Asn 
            20                  25                  30          


Ser Arg Ile Phe Pro Ala Ala Thr Ala Asp Ser Asn Val Glu Arg Arg 
        35                  40                  45              


Gly Phe Arg Gln Gly Arg Arg Leu Val Arg Arg Lys Lys His Arg Lys 
    50                  55                  60                  


Val Arg Leu Ala Asp Leu Phe Leu Asp Ser Asn Leu Leu Thr Asp Phe 
65                  70                  75                  80  


Ser Lys Val Ser Leu Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly 
                85                  90                  95      


Leu Asn Glu Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Ser 
            100                 105                 110         


Ile Val Ser Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Glu Asp 
        115                 120                 125             


Ser Gly Ala Asn Ser Ser Glu Tyr Gly Lys Ala Val Glu Glu Asn Arg 
    130                 135                 140                 


Lys Leu Leu Glu Asp Arg Thr Pro Gly Gln Ile Gln Leu Glu Arg Phe 
145                 150                 155                 160 


Glu Lys Tyr Gly Lys Val Arg Gly Asp Phe Thr Val Val Glu Asn Gly 
                165                 170                 175     


Glu Asn His Arg Leu Ile Asn Val Phe Ser Thr Ser Ala Tyr Lys Lys 
            180                 185                 190         


Glu Ala Glu Arg Ile Leu Arg Arg Gln Gln Glu Phe Asn Ile Arg Ile 
        195                 200                 205             


Ala Asp Glu Phe Ile Glu Ala Tyr Leu Thr Ile Leu Thr Gly Lys Arg 
    210                 215                 220                 


Lys Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly 
225                 230                 235                 240 


Arg Phe Arg Thr Asp Gly Thr Thr Leu Asp Asn Ile Phe Gly Ile Leu 
                245                 250                 255     


Ile Gly Lys Cys Thr Phe Tyr Pro Asp Glu Tyr Arg Ala Ala Lys Ala 
            260                 265                 270         


Ser Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu 
        275                 280                 285             


Thr Val Pro Thr Glu Thr Lys Lys Leu Ser Glu Glu Gln Lys Arg Gln 
    290                 295                 300                 


Ile Ile Glu His Ala Lys Thr Val Lys Thr Leu Gly Ala Pro Thr Leu 
305                 310                 315                 320 


Leu Lys Tyr Ile Ala Lys Leu Val Gly Cys Ser Ala Asp Asp Ile Lys 
                325                 330                 335     


Gly Tyr Arg Ile Asp Lys Ser Asp Lys Pro Glu Ile His Thr Phe Glu 
            340                 345                 350         


Ala Tyr Arg Lys Met Arg Thr Met Glu Leu Ile Lys Val Ala Asp Leu 
        355                 360                 365             


Ser Arg Glu Ser Leu Asp Ala Leu Ala His Ile Leu Thr Leu Asn Thr 
    370                 375                 380                 


Glu Arg Glu Gly Ile Glu Glu Ala Ile Arg Asp Arg Phe Thr Asn Lys 
385                 390                 395                 400 


Glu Phe Asn Gln Glu Gln Ile Asn Glu Leu Val Leu Phe Arg Lys Asn 
                405                 410                 415     


Asn Ser Ser Leu Phe Gly Lys Gly Trp His Asn Phe Ser Leu Lys Leu 
            420                 425                 430         


Met Lys Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met 
        435                 440                 445             


Thr Ile Leu Thr Arg Leu Gly Lys Gln Arg Val Lys Lys Ser Ser Asn 
    450                 455                 460                 


Arg Thr Asn Tyr Ile Asp Glu Lys Glu Leu Thr Glu Glu Ile Tyr Asn 
465                 470                 475                 480 


Pro Val Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Ile Asn Leu 
                485                 490                 495     


Ala Thr Lys Lys Tyr Gly Val Phe Asp Asn Ile Val Ile Glu Met Ala 
            500                 505                 510         


Arg Glu Ser Asn Glu Asp Asp Glu Lys Lys Ala Ile Gln Asn Ala Gln 
        515                 520                 525             


Lys Ala Asn Glu Asp Glu Lys Glu Ala Ala Leu Leu Lys Ala Ala His 
    530                 535                 540                 


Gln Phe Asn Gly Lys Glu Glu Leu Pro Asp Ser Ile Phe His Gly His 
545                 550                 555                 560 


Lys Glu Leu Leu Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Lys 
                565                 570                 575     


Cys Leu Tyr Thr Gly Lys Thr Ile Phe Ile Asn Asp Leu Ile His Asn 
            580                 585                 590         


Pro Tyr Lys Tyr Glu Ile Asp His Ile Leu Pro Leu Ser Leu Ser Phe 
        595                 600                 605             


Asp Asp Ser Leu Ala Asn Lys Val Leu Val Leu Ser Thr Ala Asn Gln 
    610                 615                 620                 


Glu Lys Gly Gln Arg Thr Pro Phe Gln Ser Leu Asp Ser Met Asp Gly 
625                 630                 635                 640 


Ala Trp Thr Tyr Arg Glu Phe Lys Ala Tyr Val Lys Gly Leu Lys Thr 
                645                 650                 655     


Leu Ser Asn Lys Lys Lys Asp Tyr Leu Leu Asn Glu Glu Asp Ile Asn 
            660                 665                 670         


Lys Asn Glu Val Lys Gln Lys Phe Ile Glu Arg Asn Leu Val Asp Thr 
        675                 680                 685             


Arg Tyr Ser Ser Arg Val Val Leu Asn Thr Leu Gln Asp Phe Tyr Lys 
    690                 695                 700                 


Lys Arg Glu Phe Asp Thr Lys Ile Ser Val Val Arg Gly Gln Phe Thr 
705                 710                 715                 720 


Ser Gln Ile Arg Arg Lys Trp Arg Ile Glu Lys Thr Arg Glu Thr Tyr 
                725                 730                 735     


His His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu 
            740                 745                 750         


Asn Leu Trp Lys Lys Gln Asn Asn Pro Leu Ile Ser Tyr Lys Glu Asp 
        755                 760                 765             


Gln Phe Val Asp Pro Glu Thr Gly Glu Ile Leu Ser Leu Ser Asp Asp 
    770                 775                 780                 


Glu Tyr Lys Glu Leu Val Phe Lys Ala Pro Tyr Asp His Phe Val Asp 
785                 790                 795                 800 


Thr Leu Lys Ser Lys Lys Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln 
                805                 810                 815     


Val Asp Ser Lys Tyr Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Gly 
            820                 825                 830         


Thr Arg Lys Ala Arg Leu Gly Lys Asp Ser Gln Glu Glu Thr Tyr Val 
        835                 840                 845             


Leu Gly Lys Ile Lys Asp Ile Tyr Ser Gln Lys Gly Tyr Glu Asp Phe 
    850                 855                 860                 


Ile Lys Lys Tyr Lys Lys Asp Lys Thr Gln Phe Leu Met Tyr His Lys 
865                 870                 875                 880 


Asp Pro Gln Thr Phe Glu Lys Val Ile Glu Glu Ile Leu Lys Thr Tyr 
                885                 890                 895     


Ser Asp Lys Glu Leu Asn Glu Lys Gly Lys Glu Val Pro Cys Asn Pro 
            900                 905                 910         


Phe Glu Lys Tyr Arg Gln Glu Asn Gly Pro Val Arg Lys Tyr Ser Lys 
        915                 920                 925             


Lys Gly Asn Gly Pro Glu Ile Lys Ser Ile Lys Tyr Tyr Asp Asn Lys 
    930                 935                 940                 


Leu Gly Asn His Ile Asp Ile Thr Pro Asn Asn Ser His His Gln Val 
945                 950                 955                 960 


Val Leu Gln Ser Leu Lys Pro Trp Arg Thr Asp Val Tyr Phe Asn Pro 
                965                 970                 975     


Lys Ser Gly Lys Tyr Glu Leu Met Gly Leu Lys Tyr Ser Asp Leu Arg 
            980                 985                 990         


Phe Glu Lys Val Ser Gly Asp Tyr  Gly Ile Ser Val Lys  Lys Tyr Asn 
        995                 1000                 1005             


Glu Ile  Lys Ser Lys Glu Gly  Val Asp Glu Asn Ser  Glu Phe Lys 
    1010                 1015                 1020             


Phe Thr  Leu Tyr Lys Asn Asp  Leu Ile Leu Ile Lys  Asp Thr Glu 
    1025                 1030                 1035             


Ser Gly  Glu Gln Glu Leu Phe  Arg Phe Leu Ser Arg  Thr Met Pro 
    1040                 1045                 1050             


Asn Gln  Lys His Tyr Val Glu  Leu Lys Pro Tyr Asp  Lys Ser Lys 
    1055                 1060                 1065             


Phe Glu  Gly His Gln Lys Leu  Met Asp Ile Phe Gly  Glu Val Ala 
    1070                 1075                 1080             


Lys Gly  Gly Gln Cys Leu Lys  Gly Leu Asn Lys Ser  Asn Ile Ser 
    1085                 1090                 1095             


Ile Tyr  Lys Val Lys Thr Asp  Val Leu Gly Asn Lys  Tyr Phe Ile 
    1100                 1105                 1110             


Lys Lys  Glu Gly Asp Gln Pro  Gln Leu Asn Phe Lys  Lys Lys Ile 
    1115                 1120                 1125             


<210> 518
<211> 1125
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans NLML8

<400> 518
Met Thr Asn Gly Lys Ile Leu Gly Leu Asp Ile Gly Ile Ala Ser Val 
1               5                   10                  15      


Gly Val Gly Ile Ile Asn Ala Lys Thr Gly Asn Val Glu His Ala Ser 
            20                  25                  30          


Ser Arg Ile Phe Pro Ala Ala Asn Ala Asp Asn Asn Val Glu Arg Arg 
        35                  40                  45              


Ser Ala Arg Gly Gly Arg Arg Leu Ile Arg Arg Lys Lys His Arg Leu 
    50                  55                  60                  


Lys Arg Val Glu Asp Leu Phe Glu Lys Tyr Asn Ile Asp Thr Asp Phe 
65                  70                  75                  80  


Ser Asn Leu Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu Asn 
                85                  90                  95      


Glu Gln Leu Ser Asn Glu Glu Leu Phe Ala Ile Leu Lys Asn Ile Ala 
            100                 105                 110         


Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Glu Asp Asp Ser Val 
        115                 120                 125             


Gly Ser Ser Asp Tyr Ala Lys Ala Ile Asp Glu Asn Arg Lys Leu Leu 
    130                 135                 140                 


Lys Lys Gln Thr Pro Gly Glu Ile Gln Leu Lys Arg Leu Glu Lys Tyr 
145                 150                 155                 160 


Gly Gln Leu Arg Gly Asn Phe Thr Ile Gln Asp Glu Asn Gly Glu Tyr 
                165                 170                 175     


His Arg Leu Ile Asn Val Phe Ser Thr Ser Asp Tyr Val Lys Glu Ala 
            180                 185                 190         


Arg Arg Ile Leu Glu Thr Gln Ser Tyr Tyr Asn Lys Phe Ile Thr Glu 
        195                 200                 205             


Ser Phe Val Glu Asp Tyr Ile Lys Ile Leu Gln Gly Lys Arg Lys Tyr 
    210                 215                 220                 


Tyr Val Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Ile Tyr 
225                 230                 235                 240 


Arg Thr Asp Gly Glu Thr Leu Asp Asn Leu Phe Gly Ile Leu Ile Gly 
                245                 250                 255     


Lys Cys Gly Phe Tyr Pro Glu Glu Tyr Arg Ala Ala Lys Ala Ser Tyr 
            260                 265                 270         


Thr Ala Gln Glu Tyr Asn Phe Leu Asn Asp Leu Asn Asn Leu Thr Val 
        275                 280                 285             


Pro Thr Glu Thr Lys Lys Leu Ser Thr Glu Gln Lys Tyr Gln Leu Val 
    290                 295                 300                 


Asp Phe Ala Lys Thr Ala Ser Thr Leu Glu Ala Ala Lys Leu Leu Lys 
305                 310                 315                 320 


Glu Ile Ala Lys Leu Val Gly Cys Gln Val Glu Glu Ile Lys Gly Tyr 
                325                 330                 335     


Arg Leu Asp Asn Lys Asp Lys Pro Asp Leu His Thr Phe Glu Pro Phe 
            340                 345                 350         


Arg Lys Leu Lys Ser Asn Leu Thr Thr Ile Ala Val Glu Asn Leu Ser 
        355                 360                 365             


Ile Thr Thr Leu Asp Thr Leu Ala His Ile Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Glu Glu Ala Ile Gln Lys Glu Leu Pro Asn Ile Phe 
385                 390                 395                 400 


Ser Asp Glu Gln Ile Thr Gly Ile Ile Ala Val Arg Lys Lys Asn Ser 
                405                 410                 415     


Gln Ile Phe Gly Lys Gly Trp His Ser Phe Ser Ile Lys Leu Met Lys 
            420                 425                 430         


Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr Ile 
        435                 440                 445             


Leu Ile Arg Leu Lys Lys Val Lys Thr Asn Ser Lys Ile Thr Asn Arg 
    450                 455                 460                 


Thr Lys Tyr Ile Asn Glu Gln Glu Val Thr Asp Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ser Lys Ser Ile Arg Gln Thr Val Lys Ile Ile Asn Ala Ala 
                485                 490                 495     


Ile Lys Lys Tyr Gly Ala Phe Asp Gln Ile Val Ile Glu Met Pro Arg 
            500                 505                 510         


Glu Ser Asn Glu Glu Asp Glu Arg Lys Phe Ile Ala Asp Leu Gln Lys 
        515                 520                 525             


Ser Asn Ala Lys Glu Lys Asp Asp Ala Met Lys Gln Ala Ala Leu Leu 
    530                 535                 540                 


Tyr Asn Gly Lys Ala Glu Leu Pro His Gly Val Phe His Gly His Lys 
545                 550                 555                 560 


Glu Leu Ala Thr Lys Ile Arg Leu Trp Tyr Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Leu Tyr Ser Gly Lys His Ile Asp Ile His Asp Leu Ile His Asn Gln 
            580                 585                 590         


His Met Phe Glu Ile Asp His Val Leu Pro Leu Ser Leu Ser Phe Asp 
        595                 600                 605             


Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ser Trp Ala Asn Gln Glu 
    610                 615                 620                 


Lys Gly Gln Arg Thr Pro Phe Gln Ala Leu Pro Gln Met Ala Ser Ala 
625                 630                 635                 640 


Trp Ser Phe Arg Glu Leu Arg Asp Tyr Ile Ser Lys Gln Lys Gly Ile 
                645                 650                 655     


Ser Lys Lys Lys Arg Asp Tyr Leu Leu Thr Glu Gln Asp Ile Asn Lys 
            660                 665                 670         


Val Glu Val Lys Gln Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Val Ser Arg Val Val Leu Asn Thr Leu Gln Asp Ala Leu Lys Val 
    690                 695                 700                 


Met Asn Lys Glu Thr Lys Ile Ser Val Ile Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg Arg Gln Trp Arg Ile Asp Lys Ser Arg Glu Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Arg 
            740                 745                 750         


Leu Trp Lys Lys Gln Asn Asn Pro Met Phe Ala Glu Asp Lys His Gly 
        755                 760                 765             


Gln Lys Ile Asn Leu Asp Thr Gly Glu Val Leu Ser Asp Asp Ala Tyr 
    770                 775                 780                 


Lys Glu Leu Val Tyr Gln Ala Pro Tyr Gln Gly Phe Val Asn Thr Ile 
785                 790                 795                 800 


Ser Ser Lys Ser Phe Glu Asp Glu Ile Leu Phe Ser Tyr Gln Val Asp 
                805                 810                 815     


Ser Lys Val Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg 
            820                 825                 830         


Gln Ala Gln Leu Gly Lys Asp Lys Lys Glu Glu Thr Tyr Val Leu Gly 
        835                 840                 845             


Lys Ile Lys Asp Ile Tyr Ser Gln Ala Gly Tyr Asp Ala Phe Arg Lys 
    850                 855                 860                 


Lys Tyr Asp Lys Asp Lys Ala Val Phe Leu Met Tyr Gln Lys Asp Pro 
865                 870                 875                 880 


Glu Thr Trp Glu Lys Val Ile Glu Val Ile Leu Arg Asp Tyr Lys Glu 
                885                 890                 895     


Leu Asp Asp Lys Gly Lys Glu Ile Gly Asn Pro Phe Glu Arg Tyr Lys 
            900                 905                 910         


Val Lys His Gly Phe Val Arg Lys Tyr Ser Arg Lys Asn Lys Gly Thr 
        915                 920                 925             


Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Asn Lys Leu Gly Asn His Ile 
    930                 935                 940                 


Asp Ile Thr Pro Asn Asn Ser Lys His Ser Val Val Leu Gln Ser Ile 
945                 950                 955                 960 


Asn Pro Trp Arg Ala Asp Leu Tyr Phe Asn Pro Glu Thr Thr Lys Tyr 
                965                 970                 975     


Glu Leu Met Gly Leu Lys Tyr Ala Asp Leu Ser Phe Glu Lys Gly Thr 
            980                 985                 990         


Gly Lys Tyr Ser Ile Ser Arg Glu  Lys Tyr Asp Glu Ile  Lys Glu Arg 
        995                 1000                 1005             


Glu Gly  Ile Ser Ser Lys Ser  Glu Phe Lys Phe Thr  Leu Tyr Lys 
    1010                 1015                 1020             


Asn Asp  Leu Ile Leu Val Lys  Asp Ile Gly Asn His  Lys Glu Leu 
    1025                 1030                 1035             


Ile Ala  Arg Phe Asn Ser Lys  Asn Asp Thr Ser Lys  His Tyr Val 
    1040                 1045                 1050             


Glu Leu  Lys Pro Trp Asn Lys  Ala Lys Phe Asp Ser  Glu Glu Glu 
    1055                 1060                 1065             


Leu Ile  Pro Ala Phe Gly Lys  Val Ala Lys Ser Gly  Gln Phe Ile 
    1070                 1075                 1080             


Lys Gly  Leu Asn Lys Pro Asp  Leu Ser Ile Tyr Lys  Val Lys Thr 
    1085                 1090                 1095             


Asp Ile  Leu Gly His Lys Tyr  Tyr Ile Lys Lys Glu  Gly Asp Lys 
    1100                 1105                 1110             


Pro Lys  Leu Asn Phe Glu Asn  Lys Ile Lys Asn Lys  
    1115                 1120                 1125 


<210> 519
<211> 1125
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans NLML8

<400> 519
Met Thr Asn Gly Lys Ile Leu Gly Leu Asp Ile Gly Ile Ala Ser Val 
1               5                   10                  15      


Gly Val Gly Ile Ile Asn Ala Lys Thr Gly Asn Val Glu His Ala Ser 
            20                  25                  30          


Ser Arg Ile Phe Pro Ala Ala Asn Ala Asp Asn Asn Val Glu Arg Arg 
        35                  40                  45              


Ser Ala Arg Gly Gly Arg Arg Leu Ile Arg Arg Lys Lys His Arg Leu 
    50                  55                  60                  


Lys Arg Val Glu Asp Leu Phe Glu Lys Tyr Asn Ile Asp Thr Asp Phe 
65                  70                  75                  80  


Ser Asn Leu Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu Asn 
                85                  90                  95      


Glu Gln Leu Ser Asn Glu Glu Leu Phe Ala Ile Leu Lys Asn Ile Ala 
            100                 105                 110         


Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Glu Asp Asp Ser Val 
        115                 120                 125             


Gly Ser Ser Asp Tyr Ala Lys Ala Ile Asp Glu Asn Arg Lys Leu Leu 
    130                 135                 140                 


Lys Lys Gln Thr Pro Gly Glu Ile Gln Leu Lys Arg Leu Glu Lys Tyr 
145                 150                 155                 160 


Gly Gln Leu Arg Gly Asn Phe Thr Ile Gln Asp Glu Asn Gly Glu Tyr 
                165                 170                 175     


His Arg Leu Ile Asn Val Phe Ser Thr Ser Asp Tyr Val Lys Glu Ala 
            180                 185                 190         


Arg Arg Ile Leu Glu Thr Gln Ser Tyr Tyr Asn Lys Phe Ile Thr Glu 
        195                 200                 205             


Ser Phe Val Glu Asp Tyr Ile Lys Ile Leu Gln Gly Lys Arg Lys Tyr 
    210                 215                 220                 


Tyr Val Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Ile Tyr 
225                 230                 235                 240 


Arg Thr Asp Gly Glu Thr Leu Asp Asn Leu Phe Gly Ile Leu Ile Gly 
                245                 250                 255     


Lys Cys Gly Phe Tyr Pro Glu Glu Tyr Arg Ala Ala Lys Ala Ser Tyr 
            260                 265                 270         


Thr Ala Gln Glu Tyr Asn Phe Leu Asn Asp Leu Asn Asn Leu Thr Val 
        275                 280                 285             


Pro Thr Glu Thr Lys Lys Leu Ser Thr Glu Gln Lys Tyr Gln Leu Val 
    290                 295                 300                 


Asp Phe Ala Lys Thr Ala Ser Thr Leu Glu Ala Ala Lys Leu Leu Lys 
305                 310                 315                 320 


Glu Ile Ala Lys Leu Val Gly Cys Gln Val Glu Glu Ile Lys Gly Tyr 
                325                 330                 335     


Arg Leu Asp Asn Lys Asp Lys Pro Asp Leu His Thr Phe Glu Pro Phe 
            340                 345                 350         


Arg Lys Leu Lys Ser Asn Leu Thr Thr Ile Ala Val Glu Asn Leu Ser 
        355                 360                 365             


Ile Thr Thr Leu Asp Thr Leu Ala His Ile Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Glu Glu Ala Ile Gln Lys Glu Leu Pro Asn Ile Phe 
385                 390                 395                 400 


Ser Asp Glu Gln Ile Thr Gly Ile Ile Ala Val Arg Lys Lys Asn Ser 
                405                 410                 415     


Gln Ile Phe Gly Lys Gly Trp His Ser Phe Ser Ile Lys Leu Met Lys 
            420                 425                 430         


Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr Ile 
        435                 440                 445             


Leu Ile Arg Leu Lys Lys Val Lys Thr Asn Ser Lys Ile Thr Asn Arg 
    450                 455                 460                 


Thr Lys Tyr Ile Asn Glu Gln Glu Val Thr Asp Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ser Lys Ser Ile Arg Gln Thr Val Lys Ile Ile Asn Ala Ala 
                485                 490                 495     


Ile Lys Lys Tyr Gly Ala Phe Asp Gln Ile Val Ile Glu Met Pro Arg 
            500                 505                 510         


Glu Ser Asn Glu Glu Asp Glu Arg Lys Phe Ile Ala Asp Leu Gln Lys 
        515                 520                 525             


Ser Asn Ala Lys Glu Lys Asp Asp Ala Met Lys Gln Ala Ala Leu Leu 
    530                 535                 540                 


Tyr Asn Gly Lys Ala Glu Leu Pro His Gly Val Phe His Gly His Lys 
545                 550                 555                 560 


Glu Leu Ala Thr Lys Ile Arg Leu Trp Tyr Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Leu Tyr Ser Gly Lys His Ile Asp Ile His Asp Leu Ile His Asn Gln 
            580                 585                 590         


His Met Phe Glu Ile Asp His Val Leu Pro Leu Ser Leu Ser Phe Asp 
        595                 600                 605             


Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ser Trp Ala Asn Gln Glu 
    610                 615                 620                 


Lys Gly Gln Arg Thr Pro Phe Gln Ala Leu Pro Gln Met Ala Ser Ala 
625                 630                 635                 640 


Trp Ser Phe Arg Glu Leu Arg Asp Tyr Ile Ser Lys Gln Lys Gly Ile 
                645                 650                 655     


Ser Lys Lys Lys Arg Asp Tyr Leu Leu Thr Glu Gln Asp Ile Asn Lys 
            660                 665                 670         


Val Glu Val Lys Gln Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Val Ser Arg Val Val Leu Asn Thr Leu Gln Asp Ala Leu Lys Val 
    690                 695                 700                 


Met Asn Lys Glu Thr Lys Ile Ser Val Ile Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg Arg Gln Trp Arg Ile Asp Lys Ser Arg Glu Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Arg 
            740                 745                 750         


Leu Trp Lys Lys Gln Asn Asn Pro Met Phe Ala Glu Asp Lys His Gly 
        755                 760                 765             


Gln Lys Ile Asn Leu Asp Thr Gly Glu Val Leu Ser Asp Asp Ala Tyr 
    770                 775                 780                 


Lys Glu Leu Val Tyr Gln Ala Pro Tyr Gln Gly Phe Val Asn Thr Ile 
785                 790                 795                 800 


Ser Ser Lys Ser Phe Glu Asp Glu Ile Leu Phe Ser Tyr Gln Val Asp 
                805                 810                 815     


Ser Lys Val Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg 
            820                 825                 830         


Gln Ala Gln Leu Gly Lys Asp Lys Lys Glu Glu Thr Tyr Val Leu Gly 
        835                 840                 845             


Lys Ile Lys Asp Ile Tyr Ser Gln Ala Gly Tyr Asp Ala Phe Arg Lys 
    850                 855                 860                 


Lys Tyr Asp Lys Asp Lys Ala Val Phe Leu Met Tyr Gln Lys Asp Pro 
865                 870                 875                 880 


Glu Thr Trp Glu Lys Val Ile Glu Val Ile Leu Arg Asp Tyr Lys Glu 
                885                 890                 895     


Leu Asp Asp Lys Gly Lys Glu Ile Gly Asn Pro Phe Glu Arg Tyr Lys 
            900                 905                 910         


Val Lys His Gly Phe Val Arg Lys Tyr Ser Arg Lys Asn Lys Gly Thr 
        915                 920                 925             


Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Asn Lys Leu Gly Asn His Ile 
    930                 935                 940                 


Asp Ile Thr Pro Asn Asn Ser Lys His Ser Val Val Leu Gln Ser Ile 
945                 950                 955                 960 


Asn Pro Trp Arg Ala Asp Leu Tyr Phe Asn Pro Glu Thr Thr Lys Tyr 
                965                 970                 975     


Glu Leu Met Gly Leu Lys Tyr Ala Asp Leu Ser Phe Glu Lys Gly Thr 
            980                 985                 990         


Gly Lys Tyr Ser Ile Ser Arg Glu  Lys Tyr Asp Glu Ile  Lys Glu Arg 
        995                 1000                 1005             


Glu Gly  Ile Ser Ser Lys Ser  Glu Phe Lys Phe Thr  Leu Tyr Lys 
    1010                 1015                 1020             


Asn Asp  Leu Ile Leu Val Lys  Asp Ile Gly Asn His  Lys Glu Leu 
    1025                 1030                 1035             


Ile Ala  Arg Phe Asn Ser Lys  Asn Asp Thr Ser Lys  His Tyr Val 
    1040                 1045                 1050             


Glu Leu  Lys Pro Trp Asn Lys  Ala Lys Phe Asp Ser  Glu Glu Glu 
    1055                 1060                 1065             


Leu Ile  Pro Ala Phe Gly Lys  Val Ala Lys Ser Gly  Gln Phe Ile 
    1070                 1075                 1080             


Lys Gly  Leu Asn Lys Pro Asp  Leu Ser Ile Tyr Lys  Val Lys Thr 
    1085                 1090                 1095             


Asp Ile  Leu Gly His Lys Tyr  Tyr Ile Lys Lys Glu  Gly Asp Lys 
    1100                 1105                 1110             


Pro Lys  Leu Asn Phe Glu Asn  Lys Ile Lys Asn Lys  
    1115                 1120                 1125 


<210> 520
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans NLML9

<400> 520
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Ser Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu His Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Thr His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 521
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans NLML9

<400> 521
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Ser Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu His Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Thr His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 522
<211> 1355
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans NMT4863

<400> 522
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Asp Glu Ser Phe Leu Thr Asp Asp Asp Lys Asn 
            100                 105                 110         


Phe Asp Ser His Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala Tyr 
        115                 120                 125             


His Gln Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ser Thr Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Lys Leu Phe Ala Asp Phe Val Gly Val Tyr 
            180                 185                 190         


Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Ser Ser Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu Lys 
    210                 215                 220                 


Leu Ile Asn Asn Tyr Pro Lys Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Thr Leu Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Ala Glu His His Glu Asp Leu Glu Lys Leu Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Asn Lys Pro Glu Leu Tyr His Asp Ile Phe Lys 
            340                 345                 350         


Asp Glu Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val Lys 
        355                 360                 365             


Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Asn Thr Leu Ser Lys Ile Thr 
    370                 375                 380                 


Gly Ser Asp Tyr Phe Leu Asp Gln Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Asp Tyr Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Ala Glu Tyr His Ser Asp Glu Ala Val Thr Pro Trp Asn Phe Asp Gln 
465                 470                 475                 480 


Val Ile Asp Lys Glu Ser Ser Ala Gln Ala Phe Ile Glu His Met Thr 
                485                 490                 495     


Asn Asn Asp Leu Tyr Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Pro Leu Tyr Glu Lys Tyr Thr Val Tyr Asn Glu Leu Thr Lys Ile Lys 
        515                 520                 525             


Tyr Val Thr Glu Ile Gly Glu Ala Lys Phe Phe Asp Ala Asn Leu Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Leu Phe Lys His Glu Arg Lys Val Thr Lys 
545                 550                 555                 560 


Lys Lys Leu Arg Thr Phe Leu Asp Lys Asn Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Ile Gln Gly Leu Asp Lys Glu Thr Glu Thr Phe Asn Ala Ser 
            580                 585                 590         


Tyr Ala Thr Tyr Gln Asp Leu Leu Lys Val Ile Lys Asp Lys Val Phe 
        595                 600                 605             


Met Asp Asn Pro Glu Asn Ala Glu Ile Leu Glu Asn Ile Val Leu Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Lys 
625                 630                 635                 640 


Tyr Ala Asp Val Phe Asp Lys Lys Val Ile Asp Gln Leu Ala Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Gln Ser Cys Lys Thr Ile Met Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Ala Gln Ser Asn Arg Asn Leu Met Gln Leu Ile Thr Asp Asp Asn Leu 
    690                 695                 700                 


Thr Phe Lys Asp Asp Ile Val Lys Ala Gln Tyr Val Asp Asn Ser Asp 
705                 710                 715                 720 


Asp Leu His Gln Val Val Gln Ser Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Lys Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Ala Lys Gly Arg Arg Asn Ser Gln Gln Arg Tyr Lys Arg 
    770                 775                 780                 


Leu Lys Glu Ala Ile Lys Ser Leu Asp Arg Asp Leu Asn His Lys Ile 
785                 790                 795                 800 


Leu Lys Glu His Pro Thr Asp Asn Gln Ala Leu Gln Asn Asn Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ser 
            820                 825                 830         


Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Ile Asp His Val Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser 
    850                 855                 860                 


Ser Lys Ala Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Glu Asp Val 
865                 870                 875                 880 


Val Asn Arg Met Arg Pro Phe Trp Asn Lys Leu Leu Ser Ser Gly Leu 
                885                 890                 895     


Ile Ser Gln Arg Lys Tyr Asn Asn Leu Thr Lys Lys Glu Leu Thr Leu 
            900                 905                 910         


Asp Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln 
        915                 920                 925             


Ile Thr Lys His Val Ala Arg Met Leu Asp Glu Arg Phe Asn Lys Glu 
    930                 935                 940                 


Phe Asp Asp Asn Asn Lys Arg Ile Arg Arg Val Lys Ile Val Thr Leu 
945                 950                 955                 960 


Lys Ser Asn Leu Val Ser Ser Phe Arg Lys Glu Phe Glu Leu Tyr Lys 
                965                 970                 975     


Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn 
            980                 985                 990         


Ala Val Val Val Lys Ala Leu Leu  Val Lys Tyr Pro Lys  Leu Glu Pro 
        995                 1000                 1005             


Glu Phe  Val Tyr Gly Glu Tyr  Pro Lys Tyr Asn Ser  Tyr Arg Glu 
    1010                 1015                 1020             


Arg Lys  Thr Ala Thr Gln Lys  Met Phe Phe Tyr Ser  Asn Ile Met 
    1025                 1030                 1035             


Asn Met  Phe Lys Ser Lys Val  Lys Leu Ala Asp Asp  Gln Ile Val 
    1040                 1045                 1050             


Glu Arg  Pro Met Ile Glu Val  Asn Asp Glu Thr Gly  Glu Ile Ala 
    1055                 1060                 1065             


Trp Asp  Lys Thr Lys His Ile  Thr Thr Val Lys Lys  Val Leu Ser 
    1070                 1075                 1080             


Tyr Pro  Gln Val Asn Ile Val  Lys Lys Val Glu Glu  Gln Thr Ile 
    1085                 1090                 1095             


Gly Gln  Asn Gly Gly Leu Phe  Asp Asp Asn Pro Lys  Ser Pro Leu 
    1100                 1105                 1110             


Glu Val  Ile Pro Ser Lys Leu  Val Pro Leu Lys Lys  Ala Leu Asn 
    1115                 1120                 1125             


Pro Glu  Lys Tyr Gly Gly Tyr  Gln Lys Pro Thr Thr  Ala Tyr Pro 
    1130                 1135                 1140             


Ile Leu  Leu Ile Val Asp Thr  Lys Gln Leu Ile Pro  Ile Ser Val 
    1145                 1150                 1155             


Met Asp  Lys Lys Arg Phe Glu  Gln Asn Pro Val Lys  Phe Leu Lys 
    1160                 1165                 1170             


Asp Lys  Gly Tyr Gln Gln Ile  Glu Lys Asn Asn Phe  Val Lys Leu 
    1175                 1180                 1185             


Pro Lys  Tyr Thr Leu Val Asp  Ile Gly Asn Gly Ile  Lys Arg Leu 
    1190                 1195                 1200             


Trp Ala  Ser Ser Lys Glu Val  His Lys Gly Asn Gln  Leu Val Val 
    1205                 1210                 1215             


Ser Lys  Lys Ser Gln Asp Leu  Leu Tyr His Ala His  His Leu Asp 
    1220                 1225                 1230             


Asn Asp  Tyr Ser Asn Glu Tyr  Val Lys Asn His Tyr  Gln Gln Phe 
    1235                 1240                 1245             


Asp Ile  Leu Phe Asn Glu Ile  Thr Ser Phe Ser Lys  Lys Cys Lys 
    1250                 1255                 1260             


Leu Gly  Lys Glu His Ile Gln  Lys Ile Glu Glu Ala  Tyr Ser Lys 
    1265                 1270                 1275             


Glu Arg  Asp Phe Ala Ser Ile  Glu Glu Leu Ala Asp  Gly Phe Ile 
    1280                 1285                 1290             


Lys Leu  Leu Gly Phe Thr Gln  Leu Gly Ala Thr Ser  Pro Phe Ser 
    1295                 1300                 1305             


Phe Leu  Gly Ile Lys Leu Asn  Gln Lys Gln Tyr Thr  Gly Lys Lys 
    1310                 1315                 1320             


Asp Tyr  Leu Leu Pro Cys Met  Glu Ala Thr Leu Ile  His Gln Ser 
    1325                 1330                 1335             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Lys Leu Gly 
    1340                 1345                 1350             


Gly Asp  
    1355 


<210> 523
<211> 1355
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans NMT4863

<400> 523
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Asp Glu Ser Phe Leu Thr Asp Asp Asp Lys Asn 
            100                 105                 110         


Phe Asp Ser His Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala Tyr 
        115                 120                 125             


His Gln Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ser Thr Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Lys Leu Phe Ala Asp Phe Val Gly Val Tyr 
            180                 185                 190         


Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Ser Ser Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu Lys 
    210                 215                 220                 


Leu Ile Asn Asn Tyr Pro Lys Glu Lys Lys Asn Thr Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Thr Leu Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Ala Glu His His Glu Asp Leu Glu Lys Leu Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Asn Lys Pro Glu Leu Tyr His Asp Ile Phe Lys 
            340                 345                 350         


Asp Glu Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val Lys 
        355                 360                 365             


Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Asn Thr Leu Ser Lys Ile Thr 
    370                 375                 380                 


Gly Ser Asp Tyr Phe Leu Asp Gln Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Asp Tyr Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Ala Glu Tyr His Ser Asp Glu Ala Val Thr Pro Trp Asn Phe Asp Gln 
465                 470                 475                 480 


Val Ile Asp Lys Glu Ser Ser Ala Gln Ala Phe Ile Glu His Met Thr 
                485                 490                 495     


Asn Asn Asp Leu Tyr Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Pro Leu Tyr Glu Lys Tyr Thr Val Tyr Asn Glu Leu Thr Lys Ile Lys 
        515                 520                 525             


Tyr Val Thr Glu Ile Gly Glu Ala Lys Phe Phe Asp Ala Asn Leu Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Leu Phe Lys His Glu Arg Lys Val Thr Lys 
545                 550                 555                 560 


Lys Lys Leu Arg Thr Phe Leu Asp Lys Asn Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Ile Gln Gly Leu Asp Lys Glu Thr Glu Thr Phe Asn Ala Ser 
            580                 585                 590         


Tyr Ala Thr Tyr Gln Asp Leu Leu Lys Val Ile Lys Asp Lys Val Phe 
        595                 600                 605             


Met Asp Asn Pro Glu Asn Ala Glu Ile Leu Glu Asn Ile Val Leu Thr 
    610                 615                 620                 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Lys 
625                 630                 635                 640 


Tyr Ala Asp Val Phe Asp Lys Lys Val Ile Asp Gln Leu Ala Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Gln Ser Cys Lys Thr Ile Met Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Ala Gln Ser Asn Arg Asn Leu Met Gln Leu Ile Thr Asp Asp Asn Leu 
    690                 695                 700                 


Thr Phe Lys Asp Asp Ile Val Lys Ala Gln Tyr Val Asp Asn Ser Asp 
705                 710                 715                 720 


Asp Leu His Gln Val Val Gln Ser Leu Ala Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly Lys Glu Pro Glu Gln Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Ala Lys Gly Arg Arg Asn Ser Gln Gln Arg Tyr Lys Arg 
    770                 775                 780                 


Leu Lys Glu Ala Ile Lys Ser Leu Asp Arg Asp Leu Asn His Lys Ile 
785                 790                 795                 800 


Leu Lys Glu His Pro Thr Asp Asn Gln Ala Leu Gln Asn Asn Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Ser 
            820                 825                 830         


Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Ile Asp His Val Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser 
    850                 855                 860                 


Ser Lys Ala Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Glu Asp Val 
865                 870                 875                 880 


Val Asn Arg Met Arg Pro Phe Trp Asn Lys Leu Leu Ser Ser Gly Leu 
                885                 890                 895     


Ile Ser Gln Arg Lys Tyr Asn Asn Leu Thr Lys Lys Glu Leu Thr Leu 
            900                 905                 910         


Asp Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln 
        915                 920                 925             


Ile Thr Lys His Val Ala Arg Met Leu Asp Glu Arg Phe Asn Lys Glu 
    930                 935                 940                 


Phe Asp Asp Asn Asn Lys Arg Ile Arg Arg Val Lys Ile Val Thr Leu 
945                 950                 955                 960 


Lys Ser Asn Leu Val Ser Ser Phe Arg Lys Glu Phe Glu Leu Tyr Lys 
                965                 970                 975     


Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn 
            980                 985                 990         


Ala Val Val Val Lys Ala Leu Leu  Val Lys Tyr Pro Lys  Leu Glu Pro 
        995                 1000                 1005             


Glu Phe  Val Tyr Gly Glu Tyr  Pro Lys Tyr Asn Ser  Tyr Arg Glu 
    1010                 1015                 1020             


Arg Lys  Thr Ala Thr Gln Lys  Met Phe Phe Tyr Ser  Asn Ile Met 
    1025                 1030                 1035             


Asn Met  Phe Lys Ser Lys Val  Lys Leu Ala Asp Asp  Gln Ile Val 
    1040                 1045                 1050             


Glu Arg  Pro Met Ile Glu Val  Asn Asp Glu Thr Gly  Glu Ile Ala 
    1055                 1060                 1065             


Trp Asp  Lys Thr Lys His Ile  Thr Thr Val Lys Lys  Val Leu Ser 
    1070                 1075                 1080             


Tyr Pro  Gln Val Asn Ile Val  Lys Lys Val Glu Glu  Gln Thr Ile 
    1085                 1090                 1095             


Gly Gln  Asn Gly Gly Leu Phe  Asp Asp Asn Pro Lys  Ser Pro Leu 
    1100                 1105                 1110             


Glu Val  Ile Pro Ser Lys Leu  Val Pro Leu Lys Lys  Ala Leu Asn 
    1115                 1120                 1125             


Pro Glu  Lys Tyr Gly Gly Tyr  Gln Lys Pro Thr Thr  Ala Tyr Pro 
    1130                 1135                 1140             


Ile Leu  Leu Ile Val Asp Thr  Lys Gln Leu Ile Pro  Ile Ser Val 
    1145                 1150                 1155             


Met Asp  Lys Lys Arg Phe Glu  Gln Asn Pro Val Lys  Phe Leu Lys 
    1160                 1165                 1170             


Asp Lys  Gly Tyr Gln Gln Ile  Glu Lys Asn Asn Phe  Val Lys Leu 
    1175                 1180                 1185             


Pro Lys  Tyr Thr Leu Val Asp  Ile Gly Asn Gly Ile  Lys Arg Leu 
    1190                 1195                 1200             


Trp Ala  Ser Ser Lys Glu Val  His Lys Gly Asn Gln  Leu Val Val 
    1205                 1210                 1215             


Ser Lys  Lys Ser Gln Asp Leu  Leu Tyr His Ala His  His Leu Asp 
    1220                 1225                 1230             


Asn Asp  Tyr Ser Asn Glu Tyr  Val Lys Asn His Tyr  Gln Gln Phe 
    1235                 1240                 1245             


Asp Ile  Leu Phe Asn Glu Ile  Thr Ser Phe Ser Lys  Lys Cys Lys 
    1250                 1255                 1260             


Leu Gly  Lys Glu His Ile Gln  Lys Ile Glu Glu Ala  Tyr Ser Lys 
    1265                 1270                 1275             


Glu Arg  Asp Phe Ala Ser Ile  Glu Glu Leu Ala Asp  Gly Phe Ile 
    1280                 1285                 1290             


Lys Leu  Leu Gly Phe Thr Gln  Leu Gly Ala Thr Ser  Pro Phe Ser 
    1295                 1300                 1305             


Phe Leu  Gly Ile Lys Leu Asn  Gln Lys Gln Tyr Thr  Gly Lys Lys 
    1310                 1315                 1320             


Asp Tyr  Leu Leu Pro Cys Met  Glu Ala Thr Leu Ile  His Gln Ser 
    1325                 1330                 1335             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Lys Leu Gly 
    1340                 1345                 1350             


Gly Asp  
    1355 


<210> 524
<211> 1345
<212> PRT
<213> Streptococcus mutans

<400> 524
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Lys His Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 525
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans NV1996

<400> 525
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Lys Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 526
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans NVAB

<400> 526
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Lys Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 527
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans NVAB

<400> 527
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Lys Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 528
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans R221

<400> 528
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Ile Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Asn  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 529
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans R221

<400> 529
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Ile Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Asn  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 530
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans S1B

<400> 530
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Asp Glu Ser Phe Leu Thr Asp Asp Asp Lys Asn 
            100                 105                 110         


Phe Asp Ser Tyr Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala Tyr 
        115                 120                 125             


His Gln Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ser Thr Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Lys Leu Phe Ala Asp Phe Val Gly Val Tyr 
            180                 185                 190         


Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Ser Ser Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu Lys 
    210                 215                 220                 


Leu Ile Asn Asn Tyr Pro Lys Glu Lys Lys Asn Thr Leu Phe Arg Asn 
225                 230                 235                 240 


Leu Val Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Thr Leu Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Ala Glu His His Glu Asp Leu Glu Lys Leu Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Asn Lys Pro Glu Leu Tyr His Asp Ile Phe Lys 
            340                 345                 350         


Asp Glu Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val Lys 
        355                 360                 365             


Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Asn Thr Leu Ser Lys Ile Ala 
    370                 375                 380                 


Gly Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Asp Tyr Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Gly Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu Tyr Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asp Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 531
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans S1B

<400> 531
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Asp Glu Ser Phe Leu Thr Asp Asp Asp Lys Asn 
            100                 105                 110         


Phe Asp Ser Tyr Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala Tyr 
        115                 120                 125             


His Gln Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ser Thr Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Ala 
                165                 170                 175     


Glu Asn Thr Asp Val Gln Lys Leu Phe Ala Asp Phe Val Gly Val Tyr 
            180                 185                 190         


Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp Ala 
        195                 200                 205             


Ser Ser Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu Lys 
    210                 215                 220                 


Leu Ile Asn Asn Tyr Pro Lys Glu Lys Lys Asn Thr Leu Phe Arg Asn 
225                 230                 235                 240 


Leu Val Ala Leu Ser Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Lys Leu Ser Glu Asp Ala Lys Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 
        275                 280                 285             


Leu Phe Thr Leu Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Ala Glu His His Glu Asp Leu Glu Lys Leu Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Asn Lys Pro Glu Leu Tyr His Asp Ile Phe Lys 
            340                 345                 350         


Asp Glu Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val Lys 
        355                 360                 365             


Gln Asp Glu Phe Tyr Lys Tyr Leu Lys Asn Thr Leu Ser Lys Ile Ala 
    370                 375                 380                 


Gly Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met His Ala Ile Leu Arg Arg Gln Gly Asp Tyr Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Gly Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu Tyr Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asp Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 532
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans SF1

<400> 532
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Lys Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 533
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans SF14

<400> 533
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asn Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Lys Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu Tyr Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Ile Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Ala  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 534
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans SF14

<400> 534
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asn Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Lys Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu Tyr Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Ile Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Ala  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 535
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans SM1

<400> 535
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Lys Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Leu Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Leu Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu Tyr Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Ile Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 536
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans SM1

<400> 536
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Lys Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Leu Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Leu Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu Tyr Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Ile Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 537
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans SM4

<400> 537
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Asp Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Lys Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 538
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans SM4

<400> 538
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Asp Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Lys Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 539
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans SM6

<400> 539
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Gly Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Ile Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 540
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans SM6

<400> 540
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Gly Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Ile Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Leu Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 541
<211> 1134
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans ST1

<400> 541
Met Ala Asn Gly Lys Ile Leu Gly Leu Asp Ile Gly Ile Ala Ser Val 
1               5                   10                  15      


Gly Val Gly Ile Ile Asp Lys Glu Thr Gly Lys Ile Ile His Val Asn 
            20                  25                  30          


Ser Arg Ile Phe Pro Ala Ala Thr Ala Asp Ser Asn Val Glu Arg Arg 
        35                  40                  45              


Gly Phe Arg Gln Gly Arg Arg Leu Val Arg Arg Lys Lys His Arg Lys 
    50                  55                  60                  


Val Arg Leu Ala Asp Leu Phe Leu Asp Ser Asn Leu Leu Thr Asp Phe 
65                  70                  75                  80  


Ser Lys Val Ser Leu Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly 
                85                  90                  95      


Leu Asn Glu Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Ser 
            100                 105                 110         


Ile Val Ser Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Glu Asp 
        115                 120                 125             


Ser Gly Ala Asn Ser Ser Glu Tyr Gly Lys Ala Val Glu Glu Asn Arg 
    130                 135                 140                 


Lys Leu Leu Glu Asp Arg Thr Pro Gly Gln Ile Gln Leu Glu Arg Phe 
145                 150                 155                 160 


Glu Lys Tyr Gly Lys Val Arg Gly Asp Phe Thr Val Val Glu Asn Gly 
                165                 170                 175     


Glu Asn His Arg Leu Ile Asn Val Phe Ser Thr Ser Ala Tyr Lys Lys 
            180                 185                 190         


Glu Ala Glu Arg Ile Leu Arg Arg Gln Gln Glu Phe Asn Met Arg Ile 
        195                 200                 205             


Ala Asp Glu Phe Ile Glu Ala Tyr Leu Thr Ile Leu Thr Gly Lys Arg 
    210                 215                 220                 


Lys Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly 
225                 230                 235                 240 


Arg Phe Arg Thr Asp Gly Thr Thr Leu Asp Asn Ile Phe Gly Ile Leu 
                245                 250                 255     


Ile Gly Lys Cys Thr Phe Tyr Pro Asp Glu Tyr Arg Ala Ala Lys Ala 
            260                 265                 270         


Ser Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu 
        275                 280                 285             


Thr Val Pro Thr Glu Thr Lys Lys Leu Ser Glu Glu Gln Lys Arg Gln 
    290                 295                 300                 


Ile Ile Glu His Ala Lys Thr Val Lys Thr Leu Gly Ala Pro Thr Leu 
305                 310                 315                 320 


Leu Lys Tyr Ile Val Lys Leu Val Gly Cys Ser Ala Asp Asp Ile Lys 
                325                 330                 335     


Gly Tyr Arg Ile Asp Lys Ser Asp Lys Pro Glu Ile His Thr Phe Glu 
            340                 345                 350         


Ala Tyr Arg Lys Met Arg Thr Met Glu Leu Ile Lys Val Asp Asp Leu 
        355                 360                 365             


Ser Arg Glu Ser Leu Asp Ala Leu Ala His Ile Leu Thr Leu Asn Thr 
    370                 375                 380                 


Glu Arg Glu Gly Ile Glu Glu Ala Ile Arg Asp Arg Phe Thr Asn Lys 
385                 390                 395                 400 


Glu Phe Asn Gln Glu Gln Ile Asn Glu Leu Val Leu Phe Arg Lys Asn 
                405                 410                 415     


Asn Ser Ser Leu Phe Gly Lys Gly Trp His Asn Phe Ser Leu Lys Leu 
            420                 425                 430         


Met Lys Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met 
        435                 440                 445             


Thr Ile Leu Thr Arg Leu Gly Lys Gln Arg Val Lys Lys Ser Ser Asn 
    450                 455                 460                 


Arg Thr Asn Tyr Ile Asp Glu Lys Glu Leu Thr Glu Glu Ile Tyr Asn 
465                 470                 475                 480 


Pro Val Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Ile Asn Leu 
                485                 490                 495     


Ala Thr Lys Lys Tyr Gly Val Phe Asp Asn Ile Val Ile Glu Met Ala 
            500                 505                 510         


Arg Glu Ser Asn Glu Asp Asp Glu Lys Lys Ala Ile Gln Asn Ala Gln 
        515                 520                 525             


Lys Ala Asn Glu Asp Glu Lys Lys Ala Ala Leu Leu Lys Ala Ala His 
    530                 535                 540                 


Gln Phe Asn Gly Lys Glu Glu Leu Pro Asp Ser Ile Phe His Gly His 
545                 550                 555                 560 


Lys Glu Leu Leu Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Lys 
                565                 570                 575     


Cys Leu Tyr Thr Gly Lys Thr Ile Phe Ile Asn Asp Leu Ile His Asn 
            580                 585                 590         


Pro Tyr Lys Tyr Glu Ile Asp His Ile Leu Pro Leu Ser Leu Ser Phe 
        595                 600                 605             


Asp Asp Ser Leu Ala Asn Lys Val Leu Val Leu Ser Thr Ala Asn Gln 
    610                 615                 620                 


Glu Lys Gly Gln Arg Thr Pro Phe Gln Ser Leu Asp Ser Met Asp Gly 
625                 630                 635                 640 


Ala Trp Thr Tyr Arg Glu Phe Lys Ser Tyr Val Lys Gly Leu Lys Thr 
                645                 650                 655     


Leu Ser Asn Lys Lys Lys Asp Tyr Leu Leu Thr Glu Glu Asn Ile Asp 
            660                 665                 670         


Lys Ile Glu Val Lys Gln Lys Phe Ile Glu Arg Asn Leu Val Asp Thr 
        675                 680                 685             


Arg Tyr Ser Ser Arg Val Val Leu Asn Ala Leu Gln Asp Phe Tyr Lys 
    690                 695                 700                 


Glu Arg Lys Phe Asp Thr Lys Ile Ser Val Val Arg Gly Gln Phe Thr 
705                 710                 715                 720 


Ser Gln Leu Arg Arg Lys Trp Arg Ile Glu Lys Thr Arg Glu Thr Tyr 
                725                 730                 735     


His His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu 
            740                 745                 750         


Asn Leu Trp Lys Lys Gln Asn Asn Pro Leu Ile Ser Tyr Lys Glu Asp 
        755                 760                 765             


Gln Phe Val Asp Pro Glu Thr Gly Glu Ile Leu Ser Leu Ser Asp Asp 
    770                 775                 780                 


Glu Tyr Lys Lys Leu Val Phe Lys Ala Pro Tyr Glu His Phe Val Asp 
785                 790                 795                 800 


Thr Leu Lys Ser Lys Lys Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln 
                805                 810                 815     


Val Asp Ser Lys Tyr Asn Arg Lys Ile Ser Gly Ala Thr Ile Cys Gly 
            820                 825                 830         


Thr Arg Lys Ala Gln Leu Gly Lys Asp Thr Gln Glu Glu Thr Tyr Val 
        835                 840                 845             


Leu Gly Lys Ile Lys Asp Ile Tyr Ser Gln Lys Gly Tyr Glu Asp Phe 
    850                 855                 860                 


Ile Lys Lys Tyr Lys Lys Asp Lys Thr Gln Phe Leu Met Tyr His Lys 
865                 870                 875                 880 


Asp Pro Gln Thr Phe Glu Lys Val Ile Glu Glu Ile Leu Lys Thr Tyr 
                885                 890                 895     


Pro Asp Lys Glu Leu Asn Glu Lys Gly Lys Glu Val Ser Cys Asn Pro 
            900                 905                 910         


Phe Glu Lys Tyr Arg Gln Glu Asn Gly Pro Val Arg Lys Tyr Ser Lys 
        915                 920                 925             


Lys Gly Asn Gly Pro Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Glu Val 
    930                 935                 940                 


Leu Gly Lys Asn Ile Asp Ile Thr Pro Lys Asn Ser Leu Asn Lys Val 
945                 950                 955                 960 


Val Leu Arg Ser Leu Asn Pro Trp Arg Thr Asp Val Tyr Phe Asn His 
                965                 970                 975     


Glu Thr Arg Lys Tyr Glu Phe Leu Gly Leu Lys Tyr Ser Asp Leu Arg 
            980                 985                 990         


Tyr Leu Lys Gly Glu His Arg Tyr  Gly Ile Leu Ile Gly  Asp Tyr Lys 
        995                 1000                 1005             


Lys Ile  Lys Asp Lys Glu Gly  Ile Glu Lys Glu Ser  Glu Phe Lys 
    1010                 1015                 1020             


Phe Thr  Leu Tyr Lys Asn Asp  Leu Ile Leu Ile Lys  Asp Thr Ala 
    1025                 1030                 1035             


Lys Gly  Lys Glu Glu Leu Phe  Arg Phe Trp Ser Arg  Thr Gly Lys 
    1040                 1045                 1050             


Asp Asn  Ala Lys Thr Phe Glu  Lys Asn Lys Ile Glu  Leu Lys Pro 
    1055                 1060                 1065             


Tyr Ser  Lys Ser Gln Phe Glu  Lys Gly Glu Asp Thr  Asn Val Leu 
    1070                 1075                 1080             


Gly Lys  Leu Tyr Ala Ser Ser  Asn Gln Leu Gln Lys  Ser Phe Gly 
    1085                 1090                 1095             


Thr Leu  Glu Asn Leu Ser Ile  Tyr Lys Val Arg Thr  Asp Val Leu 
    1100                 1105                 1110             


Gly Asn  Lys Tyr Phe Ile Lys  Lys Glu Gly Asp Lys  Pro Gln Leu 
    1115                 1120                 1125             


Asn Phe  Lys Lys Lys Leu 
    1130                 


<210> 542
<211> 1134
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans ST1

<400> 542
Met Ala Asn Gly Lys Ile Leu Gly Leu Asp Ile Gly Ile Ala Ser Val 
1               5                   10                  15      


Gly Val Gly Ile Ile Asp Lys Glu Thr Gly Lys Ile Ile His Val Asn 
            20                  25                  30          


Ser Arg Ile Phe Pro Ala Ala Thr Ala Asp Ser Asn Val Glu Arg Arg 
        35                  40                  45              


Gly Phe Arg Gln Gly Arg Arg Leu Val Arg Arg Lys Lys His Arg Lys 
    50                  55                  60                  


Val Arg Leu Ala Asp Leu Phe Leu Asp Ser Asn Leu Leu Thr Asp Phe 
65                  70                  75                  80  


Ser Lys Val Ser Leu Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly 
                85                  90                  95      


Leu Asn Glu Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Ser 
            100                 105                 110         


Ile Val Ser Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Glu Asp 
        115                 120                 125             


Ser Gly Ala Asn Ser Ser Glu Tyr Gly Lys Ala Val Glu Glu Asn Arg 
    130                 135                 140                 


Lys Leu Leu Glu Asp Arg Thr Pro Gly Gln Ile Gln Leu Glu Arg Phe 
145                 150                 155                 160 


Glu Lys Tyr Gly Lys Val Arg Gly Asp Phe Thr Val Val Glu Asn Gly 
                165                 170                 175     


Glu Asn His Arg Leu Ile Asn Val Phe Ser Thr Ser Ala Tyr Lys Lys 
            180                 185                 190         


Glu Ala Glu Arg Ile Leu Arg Arg Gln Gln Glu Phe Asn Met Arg Ile 
        195                 200                 205             


Ala Asp Glu Phe Ile Glu Ala Tyr Leu Thr Ile Leu Thr Gly Lys Arg 
    210                 215                 220                 


Lys Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly 
225                 230                 235                 240 


Arg Phe Arg Thr Asp Gly Thr Thr Leu Asp Asn Ile Phe Gly Ile Leu 
                245                 250                 255     


Ile Gly Lys Cys Thr Phe Tyr Pro Asp Glu Tyr Arg Ala Ala Lys Ala 
            260                 265                 270         


Ser Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu 
        275                 280                 285             


Thr Val Pro Thr Glu Thr Lys Lys Leu Ser Glu Glu Gln Lys Arg Gln 
    290                 295                 300                 


Ile Ile Glu His Ala Lys Thr Val Lys Thr Leu Gly Ala Pro Thr Leu 
305                 310                 315                 320 


Leu Lys Tyr Ile Val Lys Leu Val Gly Cys Ser Ala Asp Asp Ile Lys 
                325                 330                 335     


Gly Tyr Arg Ile Asp Lys Ser Asp Lys Pro Glu Ile His Thr Phe Glu 
            340                 345                 350         


Ala Tyr Arg Lys Met Arg Thr Met Glu Leu Ile Lys Val Asp Asp Leu 
        355                 360                 365             


Ser Arg Glu Ser Leu Asp Ala Leu Ala His Ile Leu Thr Leu Asn Thr 
    370                 375                 380                 


Glu Arg Glu Gly Ile Glu Glu Ala Ile Arg Asp Arg Phe Thr Asn Lys 
385                 390                 395                 400 


Glu Phe Asn Gln Glu Gln Ile Asn Glu Leu Val Leu Phe Arg Lys Asn 
                405                 410                 415     


Asn Ser Ser Leu Phe Gly Lys Gly Trp His Asn Phe Ser Leu Lys Leu 
            420                 425                 430         


Met Lys Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met 
        435                 440                 445             


Thr Ile Leu Thr Arg Leu Gly Lys Gln Arg Val Lys Lys Ser Ser Asn 
    450                 455                 460                 


Arg Thr Asn Tyr Ile Asp Glu Lys Glu Leu Thr Glu Glu Ile Tyr Asn 
465                 470                 475                 480 


Pro Val Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Ile Asn Leu 
                485                 490                 495     


Ala Thr Lys Lys Tyr Gly Val Phe Asp Asn Ile Val Ile Glu Met Ala 
            500                 505                 510         


Arg Glu Ser Asn Glu Asp Asp Glu Lys Lys Ala Ile Gln Asn Ala Gln 
        515                 520                 525             


Lys Ala Asn Glu Asp Glu Lys Lys Ala Ala Leu Leu Lys Ala Ala His 
    530                 535                 540                 


Gln Phe Asn Gly Lys Glu Glu Leu Pro Asp Ser Ile Phe His Gly His 
545                 550                 555                 560 


Lys Glu Leu Leu Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Lys 
                565                 570                 575     


Cys Leu Tyr Thr Gly Lys Thr Ile Phe Ile Asn Asp Leu Ile His Asn 
            580                 585                 590         


Pro Tyr Lys Tyr Glu Ile Asp His Ile Leu Pro Leu Ser Leu Ser Phe 
        595                 600                 605             


Asp Asp Ser Leu Ala Asn Lys Val Leu Val Leu Ser Thr Ala Asn Gln 
    610                 615                 620                 


Glu Lys Gly Gln Arg Thr Pro Phe Gln Ser Leu Asp Ser Met Asp Gly 
625                 630                 635                 640 


Ala Trp Thr Tyr Arg Glu Phe Lys Ser Tyr Val Lys Gly Leu Lys Thr 
                645                 650                 655     


Leu Ser Asn Lys Lys Lys Asp Tyr Leu Leu Thr Glu Glu Asn Ile Asp 
            660                 665                 670         


Lys Ile Glu Val Lys Gln Lys Phe Ile Glu Arg Asn Leu Val Asp Thr 
        675                 680                 685             


Arg Tyr Ser Ser Arg Val Val Leu Asn Ala Leu Gln Asp Phe Tyr Lys 
    690                 695                 700                 


Glu Arg Lys Phe Asp Thr Lys Ile Ser Val Val Arg Gly Gln Phe Thr 
705                 710                 715                 720 


Ser Gln Leu Arg Arg Lys Trp Arg Ile Glu Lys Thr Arg Glu Thr Tyr 
                725                 730                 735     


His His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu 
            740                 745                 750         


Asn Leu Trp Lys Lys Gln Asn Asn Pro Leu Ile Ser Tyr Lys Glu Asp 
        755                 760                 765             


Gln Phe Val Asp Pro Glu Thr Gly Glu Ile Leu Ser Leu Ser Asp Asp 
    770                 775                 780                 


Glu Tyr Lys Lys Leu Val Phe Lys Ala Pro Tyr Glu His Phe Val Asp 
785                 790                 795                 800 


Thr Leu Lys Ser Lys Lys Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln 
                805                 810                 815     


Val Asp Ser Lys Tyr Asn Arg Lys Ile Ser Gly Ala Thr Ile Cys Gly 
            820                 825                 830         


Thr Arg Lys Ala Gln Leu Gly Lys Asp Thr Gln Glu Glu Thr Tyr Val 
        835                 840                 845             


Leu Gly Lys Ile Lys Asp Ile Tyr Ser Gln Lys Gly Tyr Glu Asp Phe 
    850                 855                 860                 


Ile Lys Lys Tyr Lys Lys Asp Lys Thr Gln Phe Leu Met Tyr His Lys 
865                 870                 875                 880 


Asp Pro Gln Thr Phe Glu Lys Val Ile Glu Glu Ile Leu Lys Thr Tyr 
                885                 890                 895     


Pro Asp Lys Glu Leu Asn Glu Lys Gly Lys Glu Val Ser Cys Asn Pro 
            900                 905                 910         


Phe Glu Lys Tyr Arg Gln Glu Asn Gly Pro Val Arg Lys Tyr Ser Lys 
        915                 920                 925             


Lys Gly Asn Gly Pro Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Glu Val 
    930                 935                 940                 


Leu Gly Lys Asn Ile Asp Ile Thr Pro Lys Asn Ser Leu Asn Lys Val 
945                 950                 955                 960 


Val Leu Arg Ser Leu Asn Pro Trp Arg Thr Asp Val Tyr Phe Asn His 
                965                 970                 975     


Glu Thr Arg Lys Tyr Glu Phe Leu Gly Leu Lys Tyr Ser Asp Leu Arg 
            980                 985                 990         


Tyr Leu Lys Gly Glu His Arg Tyr  Gly Ile Leu Ile Gly  Asp Tyr Lys 
        995                 1000                 1005             


Lys Ile  Lys Asp Lys Glu Gly  Ile Glu Lys Glu Ser  Glu Phe Lys 
    1010                 1015                 1020             


Phe Thr  Leu Tyr Lys Asn Asp  Leu Ile Leu Ile Lys  Asp Thr Ala 
    1025                 1030                 1035             


Lys Gly  Lys Glu Glu Leu Phe  Arg Phe Trp Ser Arg  Thr Gly Lys 
    1040                 1045                 1050             


Asp Asn  Ala Lys Thr Phe Glu  Lys Asn Lys Ile Glu  Leu Lys Pro 
    1055                 1060                 1065             


Tyr Ser  Lys Ser Gln Phe Glu  Lys Gly Glu Asp Thr  Asn Val Leu 
    1070                 1075                 1080             


Gly Lys  Leu Tyr Ala Ser Ser  Asn Gln Leu Gln Lys  Ser Phe Gly 
    1085                 1090                 1095             


Thr Leu  Glu Asn Leu Ser Ile  Tyr Lys Val Arg Thr  Asp Val Leu 
    1100                 1105                 1110             


Gly Asn  Lys Tyr Phe Ile Lys  Lys Glu Gly Asp Lys  Pro Gln Leu 
    1115                 1120                 1125             


Asn Phe  Lys Lys Lys Leu 
    1130                 


<210> 543
<211> 1350
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans ST6

<400> 543
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Thr Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Ser Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Glu Asp Val Val Asn Arg Met Arg 
865                 870                 875                 880 


Pro Phe Trp Asn Lys Leu Leu Ser Ser Gly Leu Ile Ser Gln Arg Lys 
                885                 890                 895     


Tyr Asn Asn Leu Thr Lys Lys Glu Leu Thr Leu Asp Asp Lys Ala Gly 
            900                 905                 910         


Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val 
        915                 920                 925             


Ala Arg Met Leu Asp Glu Arg Phe Asn Lys Glu Phe Asp Asp Asn Asn 
    930                 935                 940                 


Lys Arg Ile Arg Lys Val Lys Ile Val Thr Leu Lys Ser Asn Leu Val 
945                 950                 955                 960 


Ser Ser Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg Glu Ile Asn 
                965                 970                 975     


Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val Val Lys 
            980                 985                 990         


Ala Leu Leu Val Lys Tyr Ser Lys  Leu Glu Pro Glu Phe  Val Tyr Gly 
        995                 1000                 1005             


Glu Tyr  Pro Lys Tyr Asn Ser  Tyr Arg Glu Arg Lys  Thr Ala Thr 
    1010                 1015                 1020             


Gln Lys  Met Phe Phe Tyr Ser  Asn Ile Met Asn Met  Phe Lys Ser 
    1025                 1030                 1035             


Lys Val  Lys Leu Ala Asp Asp  Gln Ile Val Glu Arg  Pro Met Ile 
    1040                 1045                 1050             


Glu Val  Asn Asp Glu Thr Gly  Glu Ile Ala Trp Asp  Lys Thr Lys 
    1055                 1060                 1065             


His Ile  Thr Thr Val Lys Lys  Val Leu Ser Tyr Pro  Gln Val Asn 
    1070                 1075                 1080             


Ile Val  Lys Lys Val Glu Glu  Gln Thr Ile Gly Gln  Asn Gly Gly 
    1085                 1090                 1095             


Leu Phe  Asp Asp Asn Pro Lys  Ser Pro Leu Glu Val  Ile Pro Ser 
    1100                 1105                 1110             


Lys Leu  Val Pro Leu Lys Lys  Ala Leu Asn Pro Glu  Lys Tyr Gly 
    1115                 1120                 1125             


Gly Tyr  Gln Lys Pro Thr Thr  Ala Tyr Pro Ile Leu  Leu Ile Val 
    1130                 1135                 1140             


Asp Thr  Lys Gln Leu Ile Pro  Ile Ser Val Met Asp  Lys Lys Arg 
    1145                 1150                 1155             


Phe Glu  Gln Asn Pro Val Lys  Phe Leu Lys Asp Lys  Gly Tyr Gln 
    1160                 1165                 1170             


Gln Ile  Glu Lys Asn Asn Phe  Val Lys Leu Pro Lys  Tyr Thr Leu 
    1175                 1180                 1185             


Val Asp  Ile Gly Asn Gly Ile  Lys Arg Leu Trp Ala  Ser Ser Lys 
    1190                 1195                 1200             


Glu Val  His Lys Gly Asn Gln  Leu Val Val Ser Lys  Lys Ser Gln 
    1205                 1210                 1215             


Asp Leu  Leu Tyr His Ala His  His Leu Asp Asn Asp  Tyr Ser Asn 
    1220                 1225                 1230             


Glu Tyr  Val Lys Asn His Tyr  Gln Gln Phe Asp Ile  Leu Phe Asn 
    1235                 1240                 1245             


Glu Ile  Thr Ser Phe Ser Lys  Lys Cys Lys Leu Gly  Lys Glu His 
    1250                 1255                 1260             


Ile Gln  Lys Ile Glu Glu Ala  Tyr Ser Lys Glu Arg  Asp Ser Ala 
    1265                 1270                 1275             


Ser Ile  Glu Glu Leu Ala Asp  Gly Phe Ile Lys Leu  Leu Gly Phe 
    1280                 1285                 1290             


Thr Gln  Leu Gly Ala Thr Ser  Pro Phe Ser Phe Leu  Gly Ile Lys 
    1295                 1300                 1305             


Leu Asn  Gln Lys Gln Tyr Thr  Gly Lys Lys Asp Tyr  Leu Leu Pro 
    1310                 1315                 1320             


Cys Met  Glu Ala Thr Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr 
    1325                 1330                 1335             


Glu Thr  Arg Ile Asp Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345                 1350 


<210> 544
<211> 1350
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans ST6

<400> 544
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Thr Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Ser Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Glu Asp Val Val Asn Arg Met Arg 
865                 870                 875                 880 


Pro Phe Trp Asn Lys Leu Leu Ser Ser Gly Leu Ile Ser Gln Arg Lys 
                885                 890                 895     


Tyr Asn Asn Leu Thr Lys Lys Glu Leu Thr Leu Asp Asp Lys Ala Gly 
            900                 905                 910         


Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val 
        915                 920                 925             


Ala Arg Met Leu Asp Glu Arg Phe Asn Lys Glu Phe Asp Asp Asn Asn 
    930                 935                 940                 


Lys Arg Ile Arg Lys Val Lys Ile Val Thr Leu Lys Ser Asn Leu Val 
945                 950                 955                 960 


Ser Ser Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg Glu Ile Asn 
                965                 970                 975     


Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val Val Lys 
            980                 985                 990         


Ala Leu Leu Val Lys Tyr Ser Lys  Leu Glu Pro Glu Phe  Val Tyr Gly 
        995                 1000                 1005             


Glu Tyr  Pro Lys Tyr Asn Ser  Tyr Arg Glu Arg Lys  Thr Ala Thr 
    1010                 1015                 1020             


Gln Lys  Met Phe Phe Tyr Ser  Asn Ile Met Asn Met  Phe Lys Ser 
    1025                 1030                 1035             


Lys Val  Lys Leu Ala Asp Asp  Gln Ile Val Glu Arg  Pro Met Ile 
    1040                 1045                 1050             


Glu Val  Asn Asp Glu Thr Gly  Glu Ile Ala Trp Asp  Lys Thr Lys 
    1055                 1060                 1065             


His Ile  Thr Thr Val Lys Lys  Val Leu Ser Tyr Pro  Gln Val Asn 
    1070                 1075                 1080             


Ile Val  Lys Lys Val Glu Glu  Gln Thr Ile Gly Gln  Asn Gly Gly 
    1085                 1090                 1095             


Leu Phe  Asp Asp Asn Pro Lys  Ser Pro Leu Glu Val  Ile Pro Ser 
    1100                 1105                 1110             


Lys Leu  Val Pro Leu Lys Lys  Ala Leu Asn Pro Glu  Lys Tyr Gly 
    1115                 1120                 1125             


Gly Tyr  Gln Lys Pro Thr Thr  Ala Tyr Pro Ile Leu  Leu Ile Val 
    1130                 1135                 1140             


Asp Thr  Lys Gln Leu Ile Pro  Ile Ser Val Met Asp  Lys Lys Arg 
    1145                 1150                 1155             


Phe Glu  Gln Asn Pro Val Lys  Phe Leu Lys Asp Lys  Gly Tyr Gln 
    1160                 1165                 1170             


Gln Ile  Glu Lys Asn Asn Phe  Val Lys Leu Pro Lys  Tyr Thr Leu 
    1175                 1180                 1185             


Val Asp  Ile Gly Asn Gly Ile  Lys Arg Leu Trp Ala  Ser Ser Lys 
    1190                 1195                 1200             


Glu Val  His Lys Gly Asn Gln  Leu Val Val Ser Lys  Lys Ser Gln 
    1205                 1210                 1215             


Asp Leu  Leu Tyr His Ala His  His Leu Asp Asn Asp  Tyr Ser Asn 
    1220                 1225                 1230             


Glu Tyr  Val Lys Asn His Tyr  Gln Gln Phe Asp Ile  Leu Phe Asn 
    1235                 1240                 1245             


Glu Ile  Thr Ser Phe Ser Lys  Lys Cys Lys Leu Gly  Lys Glu His 
    1250                 1255                 1260             


Ile Gln  Lys Ile Glu Glu Ala  Tyr Ser Lys Glu Arg  Asp Ser Ala 
    1265                 1270                 1275             


Ser Ile  Glu Glu Leu Ala Asp  Gly Phe Ile Lys Leu  Leu Gly Phe 
    1280                 1285                 1290             


Thr Gln  Leu Gly Ala Thr Ser  Pro Phe Ser Phe Leu  Gly Ile Lys 
    1295                 1300                 1305             


Leu Asn  Gln Lys Gln Tyr Thr  Gly Lys Lys Asp Tyr  Leu Leu Pro 
    1310                 1315                 1320             


Cys Met  Glu Ala Thr Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr 
    1325                 1330                 1335             


Glu Thr  Arg Ile Asp Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345                 1350 


<210> 545
<211> 1125
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans U2A

<400> 545
Met Thr Asn Gly Lys Ile Leu Gly Leu Asp Ile Gly Ile Ala Ser Val 
1               5                   10                  15      


Gly Val Gly Ile Ile Asn Ala Lys Thr Gly Asn Val Glu His Ala Ser 
            20                  25                  30          


Ser Arg Ile Phe Pro Ala Ala Asn Ala Asp Asn Asn Val Glu Arg Arg 
        35                  40                  45              


Ser Ala Arg Gly Gly Arg Arg Leu Ile Arg Arg Lys Lys His Arg Leu 
    50                  55                  60                  


Lys Arg Val Glu Asp Leu Phe Glu Lys Tyr Asn Ile Asp Thr Asp Phe 
65                  70                  75                  80  


Ser Asn Leu Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu Asn 
                85                  90                  95      


Glu Gln Leu Ser Asn Glu Glu Leu Phe Ala Ile Leu Lys Asn Ile Ala 
            100                 105                 110         


Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Glu Asp Asp Ser Val 
        115                 120                 125             


Gly Ser Ser Asp Tyr Ala Lys Ala Ile Asp Glu Asn Arg Lys Leu Leu 
    130                 135                 140                 


Lys Lys Gln Thr Pro Gly Glu Ile Gln Leu Lys Arg Leu Glu Lys Tyr 
145                 150                 155                 160 


Gly Gln Leu Arg Gly Asn Phe Thr Ile Gln Asp Glu Asn Gly Glu Tyr 
                165                 170                 175     


His Arg Leu Ile Asn Val Phe Ser Thr Ser Asp Tyr Val Lys Glu Ala 
            180                 185                 190         


Arg Arg Ile Leu Glu Thr Gln Ser Tyr Tyr Asn Lys Phe Ile Thr Glu 
        195                 200                 205             


Ser Phe Val Glu Asp Tyr Ile Lys Ile Leu Gln Gly Lys Arg Lys Tyr 
    210                 215                 220                 


Tyr Val Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Ile Tyr 
225                 230                 235                 240 


Arg Thr Asp Gly Glu Thr Leu Asp Asn Leu Phe Gly Ile Leu Ile Gly 
                245                 250                 255     


Lys Cys Gly Phe Tyr Pro Glu Glu Tyr Arg Ala Ala Lys Ala Ser Tyr 
            260                 265                 270         


Thr Ala Gln Glu Tyr Asn Phe Leu Asn Asp Leu Asn Asn Leu Thr Val 
        275                 280                 285             


Pro Thr Glu Thr Lys Lys Leu Ser Thr Glu Gln Lys Tyr Gln Leu Val 
    290                 295                 300                 


Asp Phe Ala Lys Thr Ala Ser Thr Leu Gly Ala Ala Lys Leu Leu Lys 
305                 310                 315                 320 


Glu Ile Ala Lys Leu Val Gly Cys Gln Val Glu Glu Ile Lys Gly Tyr 
                325                 330                 335     


Arg Leu Asp Asn Lys Asp Lys Pro Asp Leu His Thr Phe Glu Pro Phe 
            340                 345                 350         


Arg Lys Leu Lys Ser Asn Leu Thr Thr Ile Ala Val Glu Asn Leu Ser 
        355                 360                 365             


Ile Thr Thr Leu Asp Thr Leu Ala His Ile Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Glu Glu Ala Ile Gln Lys Glu Leu Pro Asn Ile Phe 
385                 390                 395                 400 


Ser Asp Glu Gln Ile Thr Glu Ile Ile Ala Val Arg Lys Lys Asn Ser 
                405                 410                 415     


Gln Ile Phe Gly Lys Gly Trp His Ser Phe Ser Ile Lys Leu Met Lys 
            420                 425                 430         


Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr Ile 
        435                 440                 445             


Leu Thr Arg Leu Lys Lys Val Lys Thr Asn Ser Lys Ile Thr Asn Arg 
    450                 455                 460                 


Thr Lys Tyr Ile Asn Glu Glu Glu Ile Thr Asp Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ser Lys Ser Ile Arg Gln Thr Val Lys Ile Ile Asn Ala Thr 
                485                 490                 495     


Ile Lys Lys Tyr Gly Ala Phe Asp Gln Ile Ile Ile Glu Met Pro Arg 
            500                 505                 510         


Glu Ser Asn Glu Glu Asp Glu Arg Lys Phe Ile Ala Asp Leu Gln Lys 
        515                 520                 525             


Ser Asn Ala Lys Glu Lys Asp Asp Ala Met Lys Gln Ala Ala Leu Leu 
    530                 535                 540                 


Tyr Asn Gly Lys Asp Glu Leu Pro His Asp Val Phe His Gly His Lys 
545                 550                 555                 560 


Glu Leu Ala Thr Lys Ile Arg Leu Trp Tyr Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Leu Tyr Ser Gly Lys His Ile Asp Ile His Asp Leu Ile His Asn Gln 
            580                 585                 590         


His Met Phe Glu Ile Asp His Val Leu Pro Leu Ser Leu Ser Phe Asp 
        595                 600                 605             


Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ser Trp Ala Asn Gln Glu 
    610                 615                 620                 


Lys Gly Gln Arg Thr Pro Phe Gln Ala Leu Pro Gln Met Ala Ser Ala 
625                 630                 635                 640 


Trp Ser Phe Arg Glu Leu Arg Asp Tyr Ile Ser Lys Gln Lys Gly Ile 
                645                 650                 655     


Ser Lys Lys Lys Arg Asp Tyr Leu Leu Thr Glu Gln Asp Ile Asn Lys 
            660                 665                 670         


Val Glu Val Lys Gln Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Val Ser Arg Val Val Leu Asn Thr Leu Gln Asp Ala Leu Lys Val 
    690                 695                 700                 


Met Asn Lys Glu Thr Lys Ile Ser Val Ile Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg Arg Gln Trp Arg Ile Asp Lys Ser Arg Glu Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Arg 
            740                 745                 750         


Leu Trp Lys Lys Gln Asn Asn Pro Met Phe Ala Glu Asp Lys His Gly 
        755                 760                 765             


Gln Lys Ile Asn Leu Asp Thr Gly Glu Val Leu Ser Asp Asp Ala Tyr 
    770                 775                 780                 


Lys Glu Leu Val Tyr Gln Ala Pro Tyr Gln Gly Phe Val Asn Thr Ile 
785                 790                 795                 800 


Ser Ser Lys Ser Phe Glu Asp Glu Ile Leu Phe Ser Tyr Gln Val Asp 
                805                 810                 815     


Ser Lys Val Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg 
            820                 825                 830         


Gln Ala Gln Leu Gly Lys Asp Lys Lys Glu Glu Thr Tyr Val Leu Gly 
        835                 840                 845             


Lys Ile Lys Asp Ile Tyr Ser Gln Ala Gly Tyr Asp Ala Phe Arg Lys 
    850                 855                 860                 


Lys Tyr Asp Lys Asp Lys Ala Val Phe Leu Met Tyr Gln Lys Asp Pro 
865                 870                 875                 880 


Glu Thr Trp Glu Lys Val Ile Glu Val Ile Leu Arg Asp Tyr Lys Glu 
                885                 890                 895     


Leu Asp Asp Lys Gly Lys Glu Ile Gly Asn Pro Phe Glu Arg Tyr Lys 
            900                 905                 910         


Val Lys His Gly Phe Val Arg Lys Tyr Ser Arg Lys Asn Lys Gly Thr 
        915                 920                 925             


Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Asn Lys Leu Gly Asn His Ile 
    930                 935                 940                 


Asp Ile Thr Pro Asn Asn Ser Lys His Ser Val Val Leu Gln Ser Ile 
945                 950                 955                 960 


Asn Pro Trp Arg Ala Asp Leu Tyr Phe Asn Pro Glu Thr Thr Lys Tyr 
                965                 970                 975     


Glu Leu Met Gly Leu Lys Tyr Ala Asp Leu Ser Phe Glu Lys Gly Thr 
            980                 985                 990         


Gly Lys Tyr Ser Ile Ser Arg Glu  Lys Tyr Asp Glu Ile  Lys Glu Arg 
        995                 1000                 1005             


Glu Gly  Ile Ser Ser Lys Ser  Glu Phe Lys Phe Thr  Leu Tyr Lys 
    1010                 1015                 1020             


Asn Asp  Leu Ile Leu Val Lys  Asp Ile Gly Asn His  Lys Glu Leu 
    1025                 1030                 1035             


Ile Ala  Arg Phe Asn Ser Lys  Asn Asp Thr Ser Lys  His Tyr Val 
    1040                 1045                 1050             


Glu Leu  Lys Pro Trp Asn Lys  Ala Lys Phe Asp Ser  Glu Glu Glu 
    1055                 1060                 1065             


Leu Ile  Pro Ala Phe Gly Lys  Val Ala Lys Ser Gly  Gln Phe Ile 
    1070                 1075                 1080             


Lys Gly  Leu Asn Lys Pro Asp  Leu Ser Ile Tyr Lys  Val Lys Thr 
    1085                 1090                 1095             


Asp Ile  Leu Gly His Lys Tyr  Tyr Ile Lys Lys Glu  Gly Asp Lys 
    1100                 1105                 1110             


Pro Lys  Leu Asn Phe Glu Asn  Lys Ile Lys Asn Lys  
    1115                 1120                 1125 


<210> 546
<211> 1125
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans U2A

<400> 546
Met Thr Asn Gly Lys Ile Leu Gly Leu Asp Ile Gly Ile Ala Ser Val 
1               5                   10                  15      


Gly Val Gly Ile Ile Asn Ala Lys Thr Gly Asn Val Glu His Ala Ser 
            20                  25                  30          


Ser Arg Ile Phe Pro Ala Ala Asn Ala Asp Asn Asn Val Glu Arg Arg 
        35                  40                  45              


Ser Ala Arg Gly Gly Arg Arg Leu Ile Arg Arg Lys Lys His Arg Leu 
    50                  55                  60                  


Lys Arg Val Glu Asp Leu Phe Glu Lys Tyr Asn Ile Asp Thr Asp Phe 
65                  70                  75                  80  


Ser Asn Leu Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu Asn 
                85                  90                  95      


Glu Gln Leu Ser Asn Glu Glu Leu Phe Ala Ile Leu Lys Asn Ile Ala 
            100                 105                 110         


Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Glu Asp Asp Ser Val 
        115                 120                 125             


Gly Ser Ser Asp Tyr Ala Lys Ala Ile Asp Glu Asn Arg Lys Leu Leu 
    130                 135                 140                 


Lys Lys Gln Thr Pro Gly Glu Ile Gln Leu Lys Arg Leu Glu Lys Tyr 
145                 150                 155                 160 


Gly Gln Leu Arg Gly Asn Phe Thr Ile Gln Asp Glu Asn Gly Glu Tyr 
                165                 170                 175     


His Arg Leu Ile Asn Val Phe Ser Thr Ser Asp Tyr Val Lys Glu Ala 
            180                 185                 190         


Arg Arg Ile Leu Glu Thr Gln Ser Tyr Tyr Asn Lys Phe Ile Thr Glu 
        195                 200                 205             


Ser Phe Val Glu Asp Tyr Ile Lys Ile Leu Gln Gly Lys Arg Lys Tyr 
    210                 215                 220                 


Tyr Val Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Ile Tyr 
225                 230                 235                 240 


Arg Thr Asp Gly Glu Thr Leu Asp Asn Leu Phe Gly Ile Leu Ile Gly 
                245                 250                 255     


Lys Cys Gly Phe Tyr Pro Glu Glu Tyr Arg Ala Ala Lys Ala Ser Tyr 
            260                 265                 270         


Thr Ala Gln Glu Tyr Asn Phe Leu Asn Asp Leu Asn Asn Leu Thr Val 
        275                 280                 285             


Pro Thr Glu Thr Lys Lys Leu Ser Thr Glu Gln Lys Tyr Gln Leu Val 
    290                 295                 300                 


Asp Phe Ala Lys Thr Ala Ser Thr Leu Gly Ala Ala Lys Leu Leu Lys 
305                 310                 315                 320 


Glu Ile Ala Lys Leu Val Gly Cys Gln Val Glu Glu Ile Lys Gly Tyr 
                325                 330                 335     


Arg Leu Asp Asn Lys Asp Lys Pro Asp Leu His Thr Phe Glu Pro Phe 
            340                 345                 350         


Arg Lys Leu Lys Ser Asn Leu Thr Thr Ile Ala Val Glu Asn Leu Ser 
        355                 360                 365             


Ile Thr Thr Leu Asp Thr Leu Ala His Ile Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Glu Glu Ala Ile Gln Lys Glu Leu Pro Asn Ile Phe 
385                 390                 395                 400 


Ser Asp Glu Gln Ile Thr Glu Ile Ile Ala Val Arg Lys Lys Asn Ser 
                405                 410                 415     


Gln Ile Phe Gly Lys Gly Trp His Ser Phe Ser Ile Lys Leu Met Lys 
            420                 425                 430         


Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr Ile 
        435                 440                 445             


Leu Thr Arg Leu Lys Lys Val Lys Thr Asn Ser Lys Ile Thr Asn Arg 
    450                 455                 460                 


Thr Lys Tyr Ile Asn Glu Glu Glu Ile Thr Asp Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ser Lys Ser Ile Arg Gln Thr Val Lys Ile Ile Asn Ala Thr 
                485                 490                 495     


Ile Lys Lys Tyr Gly Ala Phe Asp Gln Ile Ile Ile Glu Met Pro Arg 
            500                 505                 510         


Glu Ser Asn Glu Glu Asp Glu Arg Lys Phe Ile Ala Asp Leu Gln Lys 
        515                 520                 525             


Ser Asn Ala Lys Glu Lys Asp Asp Ala Met Lys Gln Ala Ala Leu Leu 
    530                 535                 540                 


Tyr Asn Gly Lys Asp Glu Leu Pro His Asp Val Phe His Gly His Lys 
545                 550                 555                 560 


Glu Leu Ala Thr Lys Ile Arg Leu Trp Tyr Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Leu Tyr Ser Gly Lys His Ile Asp Ile His Asp Leu Ile His Asn Gln 
            580                 585                 590         


His Met Phe Glu Ile Asp His Val Leu Pro Leu Ser Leu Ser Phe Asp 
        595                 600                 605             


Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ser Trp Ala Asn Gln Glu 
    610                 615                 620                 


Lys Gly Gln Arg Thr Pro Phe Gln Ala Leu Pro Gln Met Ala Ser Ala 
625                 630                 635                 640 


Trp Ser Phe Arg Glu Leu Arg Asp Tyr Ile Ser Lys Gln Lys Gly Ile 
                645                 650                 655     


Ser Lys Lys Lys Arg Asp Tyr Leu Leu Thr Glu Gln Asp Ile Asn Lys 
            660                 665                 670         


Val Glu Val Lys Gln Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Val Ser Arg Val Val Leu Asn Thr Leu Gln Asp Ala Leu Lys Val 
    690                 695                 700                 


Met Asn Lys Glu Thr Lys Ile Ser Val Ile Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg Arg Gln Trp Arg Ile Asp Lys Ser Arg Glu Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Arg 
            740                 745                 750         


Leu Trp Lys Lys Gln Asn Asn Pro Met Phe Ala Glu Asp Lys His Gly 
        755                 760                 765             


Gln Lys Ile Asn Leu Asp Thr Gly Glu Val Leu Ser Asp Asp Ala Tyr 
    770                 775                 780                 


Lys Glu Leu Val Tyr Gln Ala Pro Tyr Gln Gly Phe Val Asn Thr Ile 
785                 790                 795                 800 


Ser Ser Lys Ser Phe Glu Asp Glu Ile Leu Phe Ser Tyr Gln Val Asp 
                805                 810                 815     


Ser Lys Val Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg 
            820                 825                 830         


Gln Ala Gln Leu Gly Lys Asp Lys Lys Glu Glu Thr Tyr Val Leu Gly 
        835                 840                 845             


Lys Ile Lys Asp Ile Tyr Ser Gln Ala Gly Tyr Asp Ala Phe Arg Lys 
    850                 855                 860                 


Lys Tyr Asp Lys Asp Lys Ala Val Phe Leu Met Tyr Gln Lys Asp Pro 
865                 870                 875                 880 


Glu Thr Trp Glu Lys Val Ile Glu Val Ile Leu Arg Asp Tyr Lys Glu 
                885                 890                 895     


Leu Asp Asp Lys Gly Lys Glu Ile Gly Asn Pro Phe Glu Arg Tyr Lys 
            900                 905                 910         


Val Lys His Gly Phe Val Arg Lys Tyr Ser Arg Lys Asn Lys Gly Thr 
        915                 920                 925             


Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Asn Lys Leu Gly Asn His Ile 
    930                 935                 940                 


Asp Ile Thr Pro Asn Asn Ser Lys His Ser Val Val Leu Gln Ser Ile 
945                 950                 955                 960 


Asn Pro Trp Arg Ala Asp Leu Tyr Phe Asn Pro Glu Thr Thr Lys Tyr 
                965                 970                 975     


Glu Leu Met Gly Leu Lys Tyr Ala Asp Leu Ser Phe Glu Lys Gly Thr 
            980                 985                 990         


Gly Lys Tyr Ser Ile Ser Arg Glu  Lys Tyr Asp Glu Ile  Lys Glu Arg 
        995                 1000                 1005             


Glu Gly  Ile Ser Ser Lys Ser  Glu Phe Lys Phe Thr  Leu Tyr Lys 
    1010                 1015                 1020             


Asn Asp  Leu Ile Leu Val Lys  Asp Ile Gly Asn His  Lys Glu Leu 
    1025                 1030                 1035             


Ile Ala  Arg Phe Asn Ser Lys  Asn Asp Thr Ser Lys  His Tyr Val 
    1040                 1045                 1050             


Glu Leu  Lys Pro Trp Asn Lys  Ala Lys Phe Asp Ser  Glu Glu Glu 
    1055                 1060                 1065             


Leu Ile  Pro Ala Phe Gly Lys  Val Ala Lys Ser Gly  Gln Phe Ile 
    1070                 1075                 1080             


Lys Gly  Leu Asn Lys Pro Asp  Leu Ser Ile Tyr Lys  Val Lys Thr 
    1085                 1090                 1095             


Asp Ile  Leu Gly His Lys Tyr  Tyr Ile Lys Lys Glu  Gly Asp Lys 
    1100                 1105                 1110             


Pro Lys  Leu Asn Phe Glu Asn  Lys Ile Lys Asn Lys  
    1115                 1120                 1125 


<210> 547
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans UA159

<400> 547
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Gly Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Leu Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Asn  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 548
<211> 1345
<212> PRT
<213> Streptococcus mutans


<220>
<223> Streptococcus mutans W6

<400> 548
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 
            100                 105                 110         


Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 
        115                 120                 125             


His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gln Tyr Leu Ala Asp 
    130                 135                 140                 


Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 
                165                 170                 175     


Arg Asn Asn Asp Val Gln Arg Leu Phe Gln Glu Phe Leu Ala Val Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Asn Ser Ser Leu Gln Glu Gln Asn Val Gln Val 
        195                 200                 205             


Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Glu Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Glu 
            260                 265                 270         


Glu Glu Leu Glu Val Leu Leu Ala Gln Ile Gly Asp Asn Tyr Ala Glu 
        275                 280                 285             


Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Gln Arg Tyr Asn Glu His Gln Met Asp Leu Ala Gln Leu Lys 
                325                 330                 335     


Gln Phe Ile Arg Gln Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 
            340                 345                 350         


Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 
    370                 375                 380                 


Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Asp Asn Gln Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 
    450                 455                 460                 


Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 
465                 470                 475                 480 


Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Asn Gln Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Lys Thr Glu Gln Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 
    530                 535                 540                 


Gln Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 
545                 550                 555                 560 


Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 
                565                 570                 575     


Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 
            580                 585                 590         


Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 
        595                 600                 605             


Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 
625                 630                 635                 640 


Ser Asp Leu Leu Thr Lys Glu Gln Val Lys Lys Leu Glu Arg Arg His 
                645                 650                 655     


Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 
            660                 665                 670         


Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 
        675                 680                 685             


Asn Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Ala Leu Ser 
    690                 695                 700                 


Phe Lys Glu Glu Ile Ala Lys Ala Gln Val Ile Gly Glu Thr Asp Asn 
705                 710                 715                 720 


Leu Asn Gln Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 
            740                 745                 750         


Gly His Gln Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Phe Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Leu Lys Gly Leu 
    770                 775                 780                 


Thr Asp Ser Ile Lys Glu Phe Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu His Ser Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 
865                 870                 875                 880 


Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 
    930                 935                 940                 


Glu Asn Asn Lys Lys Ile Arg Gln Val Lys Ile Val Thr Leu Lys Ser 
945                 950                 955                 960 


Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Ile Gly Lys Ala Leu Leu Gly Val  Tyr Pro Gln Leu Glu  Pro Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Pro His  Phe His Gly His Lys  Glu Asn Lys 
    1010                 1015                 1020             


Ala Thr  Ala Lys Lys Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1025                 1030                 1035             


Lys Lys  Asp Asp Val Arg Thr  Asp Lys Asn Gly Glu  Ile Ile Trp 
    1040                 1045                 1050             


Lys Lys  Asp Glu His Ile Ser  Asn Ile Lys Lys Val  Leu Ser Tyr 
    1055                 1060                 1065             


Pro Gln  Val Asn Ile Val Lys  Lys Val Glu Glu Gln  Thr Gly Gly 
    1070                 1075                 1080             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1085                 1090                 1095             


Ile Pro  Arg Lys Thr Lys Lys  Phe Tyr Trp Asp Thr  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Gly  Phe Asp Ser Pro Ile  Val Ala Tyr Ser Ile  Leu Val Ile 
    1115                 1120                 1125             


Ala Asp  Ile Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Thr Val Lys 
    1130                 1135                 1140             


Ala Leu  Val Gly Val Thr Ile  Met Glu Lys Met Thr  Phe Glu Arg 
    1145                 1150                 1155             


Asp Pro  Val Ala Phe Leu Glu  Arg Lys Gly Tyr Arg  Asn Val Gln 
    1160                 1165                 1170             


Glu Glu  Asn Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Lys Leu 
    1175                 1180                 1185             


Glu Asn  Gly Arg Lys Arg Leu  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1190                 1195                 1200             


Lys Gly  Asn Glu Ile Val Leu  Pro Asn His Leu Gly  Thr Leu Leu 
    1205                 1210                 1215             


Tyr His  Ala Lys Asn Ile His  Lys Val Asp Glu Pro  Lys His Leu 
    1220                 1225                 1230             


Asp Tyr  Val Asp Lys His Lys  Asp Glu Phe Lys Glu  Leu Leu Asp 
    1235                 1240                 1245             


Val Val  Ser Asn Phe Ser Lys  Lys Tyr Thr Leu Ala  Glu Gly Asn 
    1250                 1255                 1260             


Leu Glu  Lys Ile Lys Glu Leu  Tyr Ala Gln Asn Asn  Gly Glu Asp 
    1265                 1270                 1275             


Leu Lys  Glu Leu Ala Ser Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1280                 1285                 1290             


Ala Ile  Gly Ala Pro Ala Thr  Phe Lys Phe Phe Asp  Lys Asn Ile 
    1295                 1300                 1305             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Thr Glu Ile Leu  Asn Ala Thr 
    1310                 1315                 1320             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1325                 1330                 1335             


Leu Ser  Lys Leu Gly Gly Asp  
    1340                 1345 


<210> 549
<211> 1121
<212> PRT
<213> Streptococcus oralis


<220>
<223> Streptococcus oralis SK1074

<400> 549
Met Asn Gly Leu Val Leu Gly Leu Asp Ile Gly Ile Ala Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Glu Lys Asn Ser Gly Lys Ile Ile His Ala Asn Ser 
            20                  25                  30          


Arg Leu Phe Pro Ala Ala Thr Ala Asp Asn Asn Val Glu Arg Arg Lys 
        35                  40                  45              


Asn Arg Gln Ala Arg Arg Leu Asn Arg Arg Lys Lys His Arg Gly Val 
    50                  55                  60                  


Arg Phe Gln Asp Leu Phe Glu Asp Tyr Gly Leu Leu Thr Asp Phe Ser 
65                  70                  75                  80  


Lys Val Ser Ile Asn Leu Asn Pro Tyr Arg Leu Arg Val Asp Gly Leu 
                85                  90                  95      


Asn Gln Gln Leu Thr Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Ile 
            100                 105                 110         


Val Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Glu Asp Gly 
        115                 120                 125             


Gly Ala Val Ser Ser Asp Tyr Gly Lys Ala Val Glu Glu Asn Arg Lys 
    130                 135                 140                 


Leu Leu Ala Glu Gln Thr Pro Gly Gln Ile Gln Leu Glu Arg Phe Glu 
145                 150                 155                 160 


Lys Tyr Gly Gln Val Arg Gly Asp Phe Thr Val Val Glu Asn Gly Glu 
                165                 170                 175     


Lys Cys Arg Leu Ile Asn Val Phe Ser Thr Ser Ala Tyr Arg Lys Glu 
            180                 185                 190         


Ala Glu Lys Ile Leu Arg Lys Gln Gln Glu Phe Asn Asn Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Glu Asp Tyr Leu Lys Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Phe Arg Thr Asp Gly Thr Thr Leu Asp Asn Ile Phe Gly Val Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Asn Glu Tyr Arg Ala Ser Lys Ser Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Glu Glu Gln Lys Lys Val Ile 
    290                 295                 300                 


Val Glu Tyr Ala Lys Glu Ala Lys Thr Leu Gly Ala Ser Thr Leu Leu 
305                 310                 315                 320 


Lys Tyr Ile Val Lys Met Ile Asp Ala Ser Val Asp Gln Ile Ser Gly 
                325                 330                 335     


Tyr Arg Val Asp Val Asn Asn Lys Pro Glu Met His Thr Phe Glu Val 
            340                 345                 350         


Tyr Arg Lys Met Gln Ser Leu Glu Thr Ile Ser Val Gly Glu Leu Ser 
        355                 360                 365             


Arg Asn Val Leu Asp Glu Leu Ala His Ile Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Glu Glu Ala Ile Asn Ser Lys Leu Met Gly Val Phe 
385                 390                 395                 400 


Ser Gln Asp Gln Val Leu Glu Leu Val Gln Phe Arg Lys Asn Asn Ser 
                405                 410                 415     


Ser Leu Phe Ser Lys Gly Trp His Asn Phe Ser Leu Lys Leu Met Met 
            420                 425                 430         


Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr Ile 
        435                 440                 445             


Leu Thr Arg Leu Gly Lys Gln Lys Ser Lys Glu Thr Ser Lys Arg Thr 
    450                 455                 460                 


Lys Tyr Ile Asp Glu Lys Glu Leu Thr Glu Glu Ile Tyr Asn Pro Val 
465                 470                 475                 480 


Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Ile Asn Glu Ala Thr 
                485                 490                 495     


Lys Lys His Gly Ile Phe Asp Asn Ile Val Ile Glu Met Ala Arg Glu 
            500                 505                 510         


Asn Asn Glu Glu Asp Ala Lys Lys Asp Tyr Ile Lys Arg Gln Lys Ala 
        515                 520                 525             


Asn Gln Asp Glu Lys Asn Ala Ala Met Glu Lys Ala Ala Phe Gln Tyr 
    530                 535                 540                 


Asn Gly Lys Lys Glu Leu Pro Gly Asn Ile Phe Asn Gly His Lys Glu 
545                 550                 555                 560 


Leu Ala Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Lys Cys Leu 
                565                 570                 575     


Tyr Thr Gly Lys Thr Ile Pro Ile Ser Asp Leu Ile His Asn Gln Tyr 
            580                 585                 590         


Lys Tyr Glu Ile Asp His Ile Leu Pro Leu Ser Leu Ser Phe Asp Asp 
        595                 600                 605             


Ser Leu Ser Asn Lys Val Leu Val His Ala Thr Ala Asn Gln Glu Lys 
    610                 615                 620                 


Gly Gln Arg Thr Pro Phe Gln Ala Leu Asp Ser Met Asp Asp Ala Trp 
625                 630                 635                 640 


Ser Tyr Arg Glu Phe Lys Ser Tyr Val Lys Asp Leu Lys Ser Leu Ser 
                645                 650                 655     


Asn Lys Lys Lys Asp Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys Ile 
            660                 665                 670         


Glu Val Lys Gln Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg Tyr 
        675                 680                 685             


Ser Ser Arg Val Val Leu Asn Ala Leu Gln Asp Phe Tyr Lys Ser His 
    690                 695                 700                 


Gln Phe Asp Thr Thr Ile Ser Val Val Arg Gly Gln Phe Thr Ser Gln 
705                 710                 715                 720 


Leu Arg Arg Lys Trp Gly Leu Glu Lys Ser Arg Glu Thr Tyr His His 
                725                 730                 735     


His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Arg Leu 
            740                 745                 750         


Trp Lys Lys Gln Asn Asn Pro Leu Ile Thr Tyr Lys Glu Gly Gln Phe 
        755                 760                 765             


Val Asp Ser Gln Thr Gly Glu Ile Ile Ser Leu Thr Asp Asp Glu Tyr 
    770                 775                 780                 


Lys Glu Leu Val Phe Lys Ala Pro Tyr Asp His Phe Val Asp Thr Leu 
785                 790                 795                 800 


His Ser Lys Thr Phe Glu Asp Gly Ile Leu Phe Ser Tyr Gln Val Asp 
                805                 810                 815     


Ser Lys Tyr Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg 
            820                 825                 830         


Lys Ala Lys Leu Asp Lys Asp Lys Ser Glu Glu Thr Tyr Val Leu Gly 
        835                 840                 845             


Lys Ile Lys Asp Ile Tyr Ser Gln Ala Gly Tyr Asp Ala Phe Ile Lys 
    850                 855                 860                 


Ile Tyr Asn Lys Asp Lys Arg Lys Phe Leu Met Tyr His Lys Asp Pro 
865                 870                 875                 880 


Gln Thr Phe Glu Lys Val Ile Glu Glu Ile Leu Arg Thr Tyr Pro Ser 
                885                 890                 895     


Lys Glu Arg Asn Asp Lys Asn Lys Glu Val Pro Cys Asn Pro Phe Glu 
            900                 905                 910         


Lys Tyr Arg Gln Glu Asn Gly Pro Ile Arg Lys Tyr Ser Lys Lys Gly 
        915                 920                 925             


Asn Gly Pro Glu Ile Lys Cys Leu Lys Tyr Tyr Asp Asn Lys Leu Gly 
    930                 935                 940                 


Asn Tyr Ile Asp Ile Ser Pro Asp Gly Ser Asp Asn Gln Val Val Leu 
945                 950                 955                 960 


Gln Ser Leu Lys Pro Trp Arg Thr Asp Val Tyr Phe Asn His Gln Thr 
                965                 970                 975     


Lys Glu Tyr Glu Leu Met Gly Leu Lys Tyr Ser Asp Leu Ser Phe Glu 
            980                 985                 990         


Lys Gly Ser Gly Lys Tyr Ser Ile  Ser Asn Glu Lys Tyr  Asn Ser Ile 
        995                 1000                 1005             


Lys Arg  Ile Glu Gly Val Asn  Glu Gln Ser Glu Phe  Lys Phe Thr 
    1010                 1015                 1020             


Leu Tyr  Lys Asn Asp Leu Ile  Leu Ile Lys Asp Ser  Glu Asn Asn 
    1025                 1030                 1035             


Glu Gln  Lys Leu Phe Arg Phe  Asn Ser Arg Asn Asp  Thr Ala Lys 
    1040                 1045                 1050             


His Tyr  Val Glu Leu Lys Pro  Tyr Asp Lys Ala Arg  Phe Asp Gly 
    1055                 1060                 1065             


Gln Gln  Glu Leu Ile Thr Ile  Leu Gly Asn Val Ala  Lys Gly Gly 
    1070                 1075                 1080             


Gln Cys  Leu Lys Gly Leu Asn  Lys Ser Asn Ile Ser  Ile Phe Lys 
    1085                 1090                 1095             


Val Lys  Thr Asp Val Leu Gly  Lys Lys His Ile Ile  Lys Lys Glu 
    1100                 1105                 1110             


Gly Asp  Glu Pro Lys Leu Lys  Phe 
    1115                 1120     


<210> 550
<211> 1373
<212> PRT
<213> Streptococcus oralis


<220>
<223> Streptococcus oralis SK304

<400> 550
Met Glu Asn Lys Asn Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys Arg Phe Ile Lys Lys Asn Leu 
        35                  40                  45              


Ile Gly Ala Leu Leu Phe Asp Glu Gly Thr Thr Ala Glu Ala Arg Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Ser 
                85                  90                  95      


Ser Phe Phe His Arg Leu Asp Asp Ser Phe Leu Ile Pro Glu Asp Lys 
            100                 105                 110         


Lys Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Ile Glu Glu Lys Glu 
        115                 120                 125             


Tyr His Lys Gln Phe Pro Thr Ile Tyr His Leu Arg Lys Gln Leu Ala 
    130                 135                 140                 


Asp Ser Lys Glu Lys Thr Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Asp Thr Phe Asp 
                165                 170                 175     


Ile Lys Asn Asn Asp Ile Gln Lys Ile Phe Asn Glu Phe Ile Ser Ile 
            180                 185                 190         


Tyr Asn Asn Thr Phe Glu Gly Asn Ser Leu Ser Gly Gln Asn Val Gln 
        195                 200                 205             


Val Glu Ala Ile Phe Thr Asp Lys Ile Ser Lys Ser Ala Lys Arg Glu 
    210                 215                 220                 


Arg Val Leu Lys Leu Phe Pro Asp Glu Lys Ser Thr Gly Leu Phe Ser 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asp Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Arg Asp Thr Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Asp Phe Ala 
        275                 280                 285             


Asp Leu Phe Val Ala Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Pro Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Glu Arg Tyr Glu Asn His Gln Lys Asp Leu Ala Thr Leu 
                325                 330                 335     


Lys Gln Phe Ile Lys Thr Asn Leu Pro Glu Lys Tyr Asp Glu Val Phe 
            340                 345                 350         


Ser Asp Gln Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr 
        355                 360                 365             


Thr Gln Glu Ser Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe 
    370                 375                 380                 


Glu Gly Ala Asp Tyr Phe Leu Glu Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met Asn Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Lys Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Arg Asp Phe Ala 
    450                 455                 460                 


Trp Leu Thr Arg Asn Ser Asp Gln Ala Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Ile Val Asp Lys Ala Ser Ser Ala Glu Ser Phe Ile Asn Lys Met 
                485                 490                 495     


Thr Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Phe Ile Ala Glu Gly Leu Arg Asp Tyr Gln Phe Leu Asp Ser Arg 
    530                 535                 540                 


Gln Lys Lys Asp Ile Phe Tyr Thr Leu Phe Lys Ala Glu Asp Lys Arg 
545                 550                 555                 560 


Lys Val Thr Glu Lys Asp Ile Ile Gln Tyr Leu His Thr Val Asp Gly 
                565                 570                 575     


Tyr Asp Gly Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser 
            580                 585                 590         


Leu Ser Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Glu Phe 
        595                 600                 605             


Met Asp Asp Pro Asn Asn Glu Glu Ile Leu Glu Asn Ile Val His Thr 
    610                 615                 620                 


Leu Thr Ile Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Gln 
625                 630                 635                 640 


Tyr Asp Ser Leu Phe Asp Glu Lys Val Ile Lys Ala Leu Thr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Lys Leu Ser Ser Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Gln Thr Gly Lys Thr Ile Leu Asp Tyr Leu Met Asp Asp 
        675                 680                 685             


Gly Tyr Asn Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Glu Leu 
    690                 695                 700                 


Ser Phe Lys Glu Ile Ile Lys Lys Ala Gln Val Val Gly Lys Thr Asp 
705                 710                 715                 720 


Asp Val Lys Gln Val Val Gln Glu Leu Pro Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Ile Lys Leu Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly His Glu Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Ala Arg Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg 
    770                 775                 780                 


Ile Glu Asp Ser Leu Lys Ile Leu Ala Ser Gly Leu Asn Ala Lys Ile 
785                 790                 795                 800 


Leu Lys Glu His Pro Thr Asp Asn Ile Gln Leu Gln Asn Asp Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Lys Pro 
            820                 825                 830         


Leu Asp Ile Asn Gln Leu Ser Ser Tyr Asp Ile Asp His Ile Val Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser 
    850                 855                 860                 


Leu Lys Asp Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Leu Glu Val 
865                 870                 875                 880 


Val Glu Lys Met Lys Thr Phe Trp Gln Gln Leu Leu Asp Ser Lys Leu 
                885                 890                 895     


Ile Ser Tyr Arg Lys Phe Asn Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Asp Glu Arg Asp Lys Val Gly Phe Ile Lys Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ala Arg Tyr 
    930                 935                 940                 


Asn Thr Glu Val Asn Glu Lys Asp Lys Lys Asn Arg Thr Val Lys Ile 
945                 950                 955                 960 


Ile Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Arg 
                965                 970                 975     


Leu Tyr Lys Ile Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Lys Lys  Tyr Pro Lys 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Gln Lys  Tyr Asp Leu 
    1010                 1015                 1020             


Lys Arg  Tyr Ile Ser Arg Ser  Lys Asp Pro Lys Glu  Ile Glu Lys 
    1025                 1030                 1035             


Ala Thr  Glu Lys Tyr Phe Phe  Tyr Ser Asn Leu Leu  Asn Phe Phe 
    1040                 1045                 1050             


Lys Glu  Glu Val His Tyr Ala  Asp Gly Thr Ile Val  Lys Arg Glu 
    1055                 1060                 1065             


Asn Ile  Glu Tyr Ser Lys Asp  Thr Gly Glu Ile Ala  Trp Asn Lys 
    1070                 1075                 1080             


Glu Lys  Asp Phe Ala Thr Ile  Lys Lys Val Leu Ser  Leu Pro Gln 
    1085                 1090                 1095             


Val Asn  Ile Val Lys Lys Arg  Glu Val Gln Thr Gly  Gly Phe Ser 
    1100                 1105                 1110             


Lys Glu  Ser Ile Leu Pro Lys  Gly Asn Ser Asp Lys  Leu Ile Pro 
    1115                 1120                 1125             


Arg Lys  Thr Lys Asp Ile Leu  Trp Asp Thr Thr Lys  Tyr Gly Gly 
    1130                 1135                 1140             


Phe Asp  Ser Pro Val Ile Ala  Tyr Ser Ile Leu Leu  Ile Ala Asp 
    1145                 1150                 1155             


Ile Glu  Lys Gly Lys Ala Lys  Arg Leu Lys Thr Val  Lys Thr Leu 
    1160                 1165                 1170             


Val Gly  Ile Thr Ile Met Glu  Lys Ala Thr Phe Glu  Lys Ser Pro 
    1175                 1180                 1185             


Ile Ala  Phe Leu Glu Asn Lys  Gly Tyr His Asn Val  Arg Lys Glu 
    1190                 1195                 1200             


Asn Ile  Leu Cys Leu Pro Lys  Tyr Ser Leu Phe Glu  Leu Lys Asn 
    1205                 1210                 1215             


Gly Arg  Arg Arg Met Leu Ala  Ser Ala Lys Glu Leu  Gln Lys Gly 
    1220                 1225                 1230             


Asn Glu  Ile Val Leu Pro Val  His Leu Thr Thr Leu  Leu Tyr His 
    1235                 1240                 1245             


Ala Lys  Asn Ile His Arg Leu  Asp Glu Pro Glu His  Leu Glu Tyr 
    1250                 1255                 1260             


Ile Gln  Lys His Arg Asn Glu  Phe Lys Gly Leu Leu  Asn Leu Val 
    1265                 1270                 1275             


Ser Glu  Phe Ser Gln Lys Tyr  Val Leu Ala Asp Ala  Asn Leu Glu 
    1280                 1285                 1290             


Lys Ile  Lys Asn Leu Tyr Ala  Asp Asn Glu Gln Ala  Asp Ile Glu 
    1295                 1300                 1305             


Ile Leu  Ala Asn Ser Phe Ile  Asn Leu Leu Thr Phe  Thr Ala Leu 
    1310                 1315                 1320             


Gly Ala  Pro Ala Ala Phe Lys  Phe Phe Gly Lys Asp  Val Asp Arg 
    1325                 1330                 1335             


Lys Arg  Tyr Thr Thr Val Ser  Glu Ile Leu Asn Ala  Thr Leu Ile 
    1340                 1345                 1350             


His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser 
    1355                 1360                 1365             


Lys Leu  Gly Glu Asp 
    1370             


<210> 551
<211> 1134
<212> PRT
<213> Streptococcus oralis


<220>
<223> Streptococcus oralis SK313

<400> 551
Met Asn Gly Leu Val Leu Gly Leu Asp Ile Gly Ile Ala Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Glu Lys Asn Ser Gly Lys Ile Val His Ala Ser Ser 
            20                  25                  30          


Arg Ile Phe Pro Ala Ala Thr Ala Asp Asn Asn Val Glu Arg Arg Lys 
        35                  40                  45              


Asn Arg Gln Ala Arg Arg Leu His Arg Arg Lys Lys His Arg Gly Ala 
    50                  55                  60                  


Arg Leu Lys Asp Leu Phe Glu Tyr Tyr Gly Leu Leu Thr Asp Phe Ser 
65                  70                  75                  80  


Lys Val Ser Ile Asn Leu Asn Pro Tyr Arg Leu Arg Val Asp Gly Leu 
                85                  90                  95      


Asp Gln Gln Leu Thr Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Ile 
            100                 105                 110         


Val Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Glu Asp Gly 
        115                 120                 125             


Gly Thr Val Ser Ser Asp Tyr Gly Lys Ala Val Glu Glu Asn Arg Lys 
    130                 135                 140                 


Leu Leu Ala Glu Gln Thr Pro Gly Gln Ile Gln Leu Glu Arg Phe Glu 
145                 150                 155                 160 


Lys Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Val Glu Asn Ser Glu 
                165                 170                 175     


Lys Cys Arg Leu Ile Asn Val Phe Ser Thr Ser Ala Tyr Lys Lys Glu 
            180                 185                 190         


Ala Glu Arg Ile Leu Arg Lys Gln Gln Glu Phe Asn Asn Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Glu Asp Tyr Leu Lys Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Phe Arg Thr Asp Gly Ala Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Asn Glu Tyr Arg Ala Ser Lys Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Glu Glu Gln Lys Lys Thr Ile 
    290                 295                 300                 


Ile Glu Tyr Ala Lys Ser Ala Lys Thr Leu Gly Ala Ser Thr Leu Leu 
305                 310                 315                 320 


Lys Tyr Ile Ala Lys Met Ile Asp Ala Ser Val Asp Gln Ile Arg Gly 
                325                 330                 335     


Tyr Arg Val Asp Val Asn Asn Lys Pro Glu Met His Thr Phe Glu Val 
            340                 345                 350         


Tyr Arg Lys Met Gln Ser Leu Glu Thr Ile Ser Val Gly Glu Leu Ser 
        355                 360                 365             


Arg Asn Ile Leu Asp Glu Leu Ala His Ile Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Glu Glu Ala Ile Asn Thr Lys Leu Arg Asp Ser Phe 
385                 390                 395                 400 


Ser Gln Asp Gln Val Leu Glu Leu Val Gln Phe Arg Lys Asn Asn Ser 
                405                 410                 415     


Ser Leu Phe Ser Lys Gly Trp His Asn Phe Ser Leu Lys Leu Met Met 
            420                 425                 430         


Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr Ile 
        435                 440                 445             


Leu Thr Arg Leu Gly Lys Gln Lys Ser Lys Glu Thr Ser Lys Arg Thr 
    450                 455                 460                 


Lys Tyr Ile Asp Glu Lys Glu Val Thr Glu Glu Ile Tyr Asn Pro Val 
465                 470                 475                 480 


Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Ile Asn Glu Ala Thr 
                485                 490                 495     


Lys Lys His Gly Ile Phe Asp Asn Ile Val Ile Glu Met Ala Arg Glu 
            500                 505                 510         


Asn Asn Glu Glu Asp Ala Lys Lys Asp Tyr Ile Lys Arg Gln Lys Ala 
        515                 520                 525             


Asn Gln Asp Glu Lys Tyr Ala Ala Met Glu Lys Ala Ala Phe Gln Tyr 
    530                 535                 540                 


Asn Gly Lys Lys Glu Leu Pro Asp Asn Ile Phe His Gly His Lys Glu 
545                 550                 555                 560 


Leu Ala Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Lys Cys Leu 
                565                 570                 575     


Tyr Thr Gly Lys Ser Ile Pro Ile Ser Asp Leu Ile His Asn Gln Tyr 
            580                 585                 590         


Lys Tyr Glu Ile Asp His Ile Leu Pro Leu Ser Leu Ser Phe Asp Asp 
        595                 600                 605             


Ser Leu Ser Asn Lys Val Leu Val Leu Ala Thr Ala Asn Gln Glu Lys 
    610                 615                 620                 


Gly Gln Arg Thr Pro Phe Gln Ala Leu Asp Ser Met Asp Asp Ala Trp 
625                 630                 635                 640 


Ser Tyr Arg Glu Phe Lys Ser Tyr Val Lys Glu Ser Lys Leu Leu Gly 
                645                 650                 655     


Asn Lys Lys Lys Glu Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys Ile 
            660                 665                 670         


Glu Val Lys Gln Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg Tyr 
        675                 680                 685             


Ser Ser Arg Val Val Leu Asn Ala Leu Gln Asp Phe Tyr Lys Asn His 
    690                 695                 700                 


Asn Phe Asp Thr Thr Ile Ser Val Val Arg Gly Gln Phe Thr Ser Gln 
705                 710                 715                 720 


Leu Arg Arg Lys Trp Gly Leu Glu Lys Ser Arg Glu Thr Tyr His His 
                725                 730                 735     


His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Arg Leu 
            740                 745                 750         


Trp Lys Lys Gln Asn Asn Pro Leu Ile Ala Tyr Lys Glu Gly Gln Phe 
        755                 760                 765             


Val Asp Ser Gln Thr Gly Glu Ile Ile Ser Leu Thr Asp Asp Glu Tyr 
    770                 775                 780                 


Lys Glu Leu Val Phe Lys Ala Pro Tyr Asp His Phe Val Asp Thr Leu 
785                 790                 795                 800 


Ser Ser Lys Thr Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln Val Asp 
                805                 810                 815     


Ser Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg 
            820                 825                 830         


Lys Ala Lys Leu Asp Lys Glu Lys Lys Glu Tyr Thr Tyr Thr Leu Gly 
        835                 840                 845             


Lys Ile Lys Asp Ile Tyr Ser Leu Gly Thr Lys Thr Pro Ser Lys Thr 
    850                 855                 860                 


Gly Phe Tyr Lys Phe Leu Asp Leu Tyr Asn Lys Asp Lys Ser Gln Phe 
865                 870                 875                 880 


Leu Met Phe Gln Lys Asp Arg Lys Thr Trp Asp Glu Val Ile Glu Lys 
                885                 890                 895     


Ile Met Glu Gln Tyr Arg Pro Phe Lys Glu Tyr Asp Lys Ala Gly Lys 
            900                 905                 910         


Leu Val Asp Phe Asn Pro Phe Glu Lys Tyr Arg Gln Glu Asn Gly Pro 
        915                 920                 925             


Ile Arg Lys Tyr Ser Lys Lys Gly Asn Gly Pro Glu Ile Lys Ser Leu 
    930                 935                 940                 


Lys Tyr Tyr Asp Ile Leu Leu Gly Lys His Lys Asn Ile Thr Pro Glu 
945                 950                 955                 960 


Gly Ser Arg Asn Thr Val Ala Leu Leu Ser Leu Asn Pro Trp Arg Thr 
                965                 970                 975     


Asp Val Tyr Tyr Asn Met Glu Thr Lys Lys Tyr Glu Phe Leu Gly Leu 
            980                 985                 990         


Lys Tyr Ala Asp Leu Pro Phe Glu  Glu Gly Gly Ala Tyr  Gly Ile Ser 
        995                 1000                 1005             


Thr Glu  Thr Tyr Asn Glu Leu  Arg Glu Lys Glu Gly  Ile Gly Lys 
    1010                 1015                 1020             


Asn Ser  Glu Phe Lys Phe Thr  Leu Tyr Lys Asn Asp  Leu Ile Leu 
    1025                 1030                 1035             


Ile Lys  Asp Thr Glu Thr Asn  Cys Gln Gln Phe Phe  Arg Phe Trp 
    1040                 1045                 1050             


Ser Arg  Thr Gly Lys Asp Asn  Pro Lys Ser Phe Glu  Lys His Lys 
    1055                 1060                 1065             


Ile Glu  Leu Lys Pro Tyr Glu  Lys Ala Lys Phe Glu  Lys Gly Glu 
    1070                 1075                 1080             


Glu Leu  Glu Val Leu Gly Lys  Val Pro Pro Ser Ser  Asn Gln Phe 
    1085                 1090                 1095             


Gln Lys  Asn Met Gln Ile Glu  Asn Leu Ser Ile Tyr  Lys Val Lys 
    1100                 1105                 1110             


Thr Asp  Val Leu Gly Asn Lys  His Phe Ile Lys Lys  Glu Gly Asp 
    1115                 1120                 1125             


Lys Pro  Lys Leu Lys Phe 
    1130                 


<210> 552
<211> 1371
<212> PRT
<213> Streptococcus oralis


<220>
<223> Streptococcus oralis SK610

<400> 552
Met Glu Asn Lys Asn Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ser Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys Arg Phe Ile Lys Lys Asn Leu 
        35                  40                  45              


Ile Gly Ala Leu Leu Phe Asp Glu Gly Thr Thr Ala Glu Ala Arg Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Ser 
                85                  90                  95      


Ser Phe Phe His Arg Leu Asp Asp Ser Phe Leu Ile Pro Glu Asp Lys 
            100                 105                 110         


Arg Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Ala Glu Glu Lys Glu 
        115                 120                 125             


Tyr His Lys Gln Phe Pro Thr Ile Tyr His Leu Arg Lys Gln Leu Ala 
    130                 135                 140                 


Asp Ser Lys Glu Lys Thr Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Asp Thr Phe Asp 
                165                 170                 175     


Ile Lys Asn Asn Asp Ile Gln Lys Ile Phe Ser Glu Phe Ile Ser Ile 
            180                 185                 190         


Tyr Asp Asn Thr Phe Glu Gly Ser Ser Leu Ser Gly Gln Asn Ala Gln 
        195                 200                 205             


Val Glu Ala Ile Phe Thr Asp Lys Ile Ser Lys Ser Ala Lys Arg Glu 
    210                 215                 220                 


Arg Val Leu Lys Leu Phe Pro Asp Glu Lys Ser Thr Gly Leu Phe Ser 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asp Leu Gly Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Asp Phe Ala 
        275                 280                 285             


Asp Leu Phe Leu Val Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Pro Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Glu Arg Tyr Glu Asn His Gln Lys Asp Leu Ala Val Leu 
                325                 330                 335     


Lys Gln Phe Ile Lys Asn Asn Leu Pro Glu Lys Tyr Asp Glu Val Phe 
            340                 345                 350         


Ser Asp Gln Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr 
        355                 360                 365             


Thr Gln Glu Ala Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe 
    370                 375                 380                 


Glu Gly Thr Asp Tyr Phe Leu Glu Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met Asn Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Pro 
            420                 425                 430         


Phe Leu Lys Asp Asn Lys Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Arg Asp Phe Ala 
    450                 455                 460                 


Trp Leu Thr Arg Asn Ser Asp Glu Ala Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Ile Val Asp Lys Ala Ser Ser Ala Glu Asp Phe Ile Asn Lys Met 
                485                 490                 495     


Thr Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Phe Ile Ala Glu Gly Leu Arg Asp Tyr Gln Phe Leu Asp Ser Gly 
    530                 535                 540                 


Gln Lys Lys Gln Ile Val Thr Gln Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile Gln Phe Leu His Asn Val Asp Gly Tyr Asp 
                565                 570                 575     


Gly Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Glu Phe Met Asp 
        595                 600                 605             


Asp Ser Lys Asn Glu Glu Ile Leu Glu Asn Ile Val His Thr Leu Thr 
    610                 615                 620                 


Ile Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Gln Tyr Asp 
625                 630                 635                 640 


Ser Leu Phe Asp Glu Lys Val Ile Lys Ala Leu Ile Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asp Gly Ile Cys Asp 
            660                 665                 670         


Lys Gln Thr Gly Asn Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Lys 
        675                 680                 685             


Asn Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu Ser Phe 
    690                 695                 700                 


Lys Glu Ile Thr Gln Lys Ala Gln Val Val Gly Lys Thr Asp Asp Val 
705                 710                 715                 720 


Lys Gln Val Val Gln Glu Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Thr Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Ala Arg Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg Ile Glu 
    770                 775                 780                 


Asp Ala Leu Lys Asn Leu Ala Ser Gly Leu Asp Ser Asn Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asn Asn Ile Gln Leu Gln Asn Asp Arg Leu Phe Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Lys Pro Leu Asp 
            820                 825                 830         


Ile Asn Gln Leu Ser Ser Tyr Asp Ile Asp His Ile Val Pro Gln Ala 
        835                 840                 845             


Phe Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser Leu Lys 
    850                 855                 860                 


Asp Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Ile Glu Val Val Gln 
865                 870                 875                 880 


Lys Arg Lys Ala Phe Trp Gln Gln Leu Leu Asp Ser Lys Leu Ile Ser 
                885                 890                 895     


Glu Arg Lys Phe Asn Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Asp 
            900                 905                 910         


Glu Arg Asp Lys Val Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ala Arg Phe Asn Lys 
    930                 935                 940                 


Glu Val Asn Glu Lys Asp Lys Lys Asn Arg Thr Val Lys Ile Ile Thr 
945                 950                 955                 960 


Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Arg Leu Tyr 
                965                 970                 975     


Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Ala Val Val Ala Lys Ala Ile  Leu Lys Lys Tyr Pro  Lys Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Asp  Tyr Gln Lys Tyr Asp  Leu Lys Arg 
    1010                 1015                 1020             


Tyr Ile  Ser Arg Ser Arg Asn  Pro Lys Glu Val Glu  Lys Ala Thr 
    1025                 1030                 1035             


Glu Lys  Tyr Phe Phe Tyr Ser  Asn Leu Leu Asn Phe  Phe Lys Glu 
    1040                 1045                 1050             


Glu Val  His Tyr Ala Asp Gly  Thr Ile Val Lys Arg  Glu Asn Ile 
    1055                 1060                 1065             


Glu Tyr  Ser Lys Asp Thr Gly  Glu Ile Ala Trp Asn  Lys Glu Lys 
    1070                 1075                 1080             


Asp Phe  Ala Thr Ile Lys Lys  Val Leu Ser Tyr Pro  Gln Val Asn 
    1085                 1090                 1095             


Ile Val  Lys Lys Arg Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1100                 1105                 1110             


Ser Ile  Leu Pro Lys Gly Asn  Ser Asp Lys Leu Ile  Pro Arg Lys 
    1115                 1120                 1125             


Thr Lys  Asp Ile Leu Trp Glu  Thr Thr Lys Tyr Gly  Gly Phe Asp 
    1130                 1135                 1140             


Ser Pro  Val Ile Ala Tyr Ser  Ile Leu Leu Ile Ala  Asp Ile Glu 
    1145                 1150                 1155             


Lys Gly  Lys Ala Lys Lys Leu  Lys Thr Val Lys Thr  Leu Val Gly 
    1160                 1165                 1170             


Ile Thr  Ile Met Glu Lys Ala  Ala Phe Glu Glu Asn  Pro Ile Thr 
    1175                 1180                 1185             


Phe Leu  Glu Asn Lys Gly Tyr  His Asn Val Arg Lys  Glu Asn Ile 
    1190                 1195                 1200             


Leu Cys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1205                 1210                 1215             


Arg Arg  Leu Leu Ala Ser Ala  Lys Glu Leu Gln Lys  Gly Asn Glu 
    1220                 1225                 1230             


Ile Val  Leu Pro Val Tyr Leu  Thr Thr Leu Leu Tyr  His Ser Lys 
    1235                 1240                 1245             


Asn Val  His Lys Leu Asp Glu  Pro Glu His Leu Glu  Tyr Ile Gln 
    1250                 1255                 1260             


Lys His  Arg Asn Glu Phe Lys  Asp Leu Leu Asn Leu  Val Ser Glu 
    1265                 1270                 1275             


Phe Ser  Gln Lys Tyr Val Leu  Ala Asp Ala Asn Leu  Glu Lys Ile 
    1280                 1285                 1290             


Gln Asn  Leu Tyr Ala Asp Asn  Glu Gln Ala Asp Ile  Glu Ile Leu 
    1295                 1300                 1305             


Ala Asn  Ser Phe Ile Asn Leu  Leu Thr Phe Thr Ala  Leu Gly Ala 
    1310                 1315                 1320             


Pro Ala  Ala Phe Lys Phe Phe  Gly Lys Asp Ile Asp  Arg Lys Arg 
    1325                 1330                 1335             


Tyr Thr  Thr Val Ser Glu Ile  Leu Asn Ala Thr Leu  Ile His Gln 
    1340                 1345                 1350             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Lys Leu 
    1355                 1360                 1365             


Gly Glu  Asp 
    1370     


<210> 553
<211> 1140
<212> PRT
<213> Streptococcus parasanguinis


<220>
<223> Streptococcus parasanguinis F0449

<400> 553
Met Asn Gly Leu Val Leu Gly Leu Asp Ile Gly Ile Ala Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Lys Lys Asp Ile Gly Glu Ile Ile His Thr Asn Ser 
            20                  25                  30          


Arg Leu Phe Ser Ala Ala Thr Ala Asp Ser Asn Ile Glu Arg Arg Gly 
        35                  40                  45              


His Arg Gly Gly Lys Arg Leu Thr Arg Arg Lys Lys His Arg Ser Ile 
    50                  55                  60                  


Arg Leu His Asp Leu Phe Glu Asp Phe Gly Leu Leu Thr Asp Phe Ser 
65                  70                  75                  80  


Lys Val Ser Ile Asn Leu Asn Pro Tyr Gln Leu Arg Val Gln Gly Leu 
                85                  90                  95      


Asp Asn Gln Leu Thr Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Ile 
            100                 105                 110         


Val Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Glu Asp Gly 
        115                 120                 125             


Gly Thr Val Ser Ser Asp Tyr Gly Lys Ala Val Glu Glu Asn Arg Lys 
    130                 135                 140                 


Leu Leu Ala Glu Gln Thr Pro Gly Gln Ile Gln Leu Asp Arg Phe Glu 
145                 150                 155                 160 


Lys Tyr Gly Gln Val Arg Gly Asp Phe Asn Val Val Glu Asn Gly Glu 
                165                 170                 175     


Lys Arg Arg Leu Ile Asn Val Phe Thr Thr Ser Ala Tyr Ser Lys Glu 
            180                 185                 190         


Ala Glu Arg Ile Leu Arg Lys Gln Gln Glu Phe Asn Lys Lys Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Glu Asp Tyr Leu Thr Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Tyr Thr Thr Lys Lys Asp Pro Glu Gly Lys Tyr Ile Thr Leu Asp Asn 
                245                 250                 255     


Ile Phe Gly Ile Leu Ile Gly Lys Cys Thr Phe Tyr Pro Asp Glu Tyr 
            260                 265                 270         


Arg Ala Ser Lys Ala Ser Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn 
        275                 280                 285             


Asp Leu Asn Asn Leu Thr Val Pro Thr Glu Thr Lys Lys Leu Ser Glu 
    290                 295                 300                 


Glu Gln Lys Lys Thr Ile Ile Lys Tyr Ala Lys Thr Ala Lys Thr Leu 
305                 310                 315                 320 


Gly Ala Ser Thr Leu Leu Lys Tyr Ile Ala Lys Leu Ile Gly Ala Ser 
                325                 330                 335     


Val Asp Gln Ile His Gly Tyr Arg Ile Asp Pro Asn Lys Lys Pro Glu 
            340                 345                 350         


Met His Thr Phe Glu Thr Tyr Arg Lys Met Gln Ser Leu Glu Thr Ile 
        355                 360                 365             


Ser Val Glu Glu Leu Pro Arg Lys Val Leu Asp Glu Leu Ala His Ile 
    370                 375                 380                 


Leu Thr Leu Asn Thr Glu Arg Glu Gly Ile Glu Glu Ala Ile Asn Ala 
385                 390                 395                 400 


Thr Leu Lys Asp Thr Phe Ser Gln Asp Gln Val Leu Glu Leu Val Gln 
                405                 410                 415     


Phe Arg Lys Asn Asn Ser Ser Leu Phe Ser Lys Gly Trp His Ser Phe 
            420                 425                 430         


Ser Leu Lys Leu Met Met Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser 
        435                 440                 445             


Glu Glu Gln Met Thr Ile Leu Thr Arg Leu Gly Lys Gln Lys Ser Lys 
    450                 455                 460                 


Glu Thr Ser Lys Arg Thr Lys Tyr Ile Asp Glu Lys Glu Leu Thr Glu 
465                 470                 475                 480 


Glu Ile Tyr Asn Pro Val Val Ala Lys Ser Val Arg Gln Ala Ile Lys 
                485                 490                 495     


Ile Ile Asn Glu Ala Thr Lys Lys Tyr Gly Ile Phe Asp Asn Ile Val 
            500                 505                 510         


Ile Glu Met Ala Arg Glu Asn Asn Glu Glu Asp Ala Lys Lys Glu Tyr 
        515                 520                 525             


Ile Lys Arg Gln Lys Ala Asn Leu Asp Glu Lys Asn Ala Ala Met Glu 
    530                 535                 540                 


Lys Ala Ala Phe Gln Tyr Asn Gly Lys Lys Glu Leu Pro Asp Asn Val 
545                 550                 555                 560 


Phe His Gly His Lys Glu Leu Ala Thr Lys Ile Arg Leu Trp His Gln 
                565                 570                 575     


Gln Gly Glu Lys Cys Leu Tyr Thr Gly Lys Asn Ile Pro Ile Ser Asp 
            580                 585                 590         


Leu Ile Gln Asn Gln Tyr Lys Tyr Glu Ile Asp His Ile Leu Pro Leu 
        595                 600                 605             


Ser Leu Ser Phe Asp Asp Ser Leu Ser Asn Lys Val Leu Val Leu Ala 
    610                 615                 620                 


Thr Ala Asn Gln Glu Lys Gly Gln Arg Thr Pro Phe Gln Ala Leu Asp 
625                 630                 635                 640 


Ser Met Asp Asp Ala Trp Ser Tyr Arg Glu Phe Lys Ser Tyr Val Lys 
                645                 650                 655     


Asp Ser Lys Leu Leu Gly Asn Lys Lys Lys Glu Tyr Leu Leu Thr Glu 
            660                 665                 670         


Glu Asp Ile Ser Lys Ile Glu Val Lys Gln Lys Phe Ile Glu Arg Asn 
        675                 680                 685             


Leu Val Asp Thr Arg Tyr Ser Ser Arg Val Val Leu Asn Ala Leu Gln 
    690                 695                 700                 


Asp Phe Tyr Lys Glu His Gln Phe Asp Thr Thr Ile Ser Val Val Arg 
705                 710                 715                 720 


Gly Gln Phe Thr Ser Gln Leu Arg Arg Lys Trp Gly Leu Glu Lys Ser 
                725                 730                 735     


Arg Glu Thr Tyr His His His Ala Val Asp Ala Leu Ile Ile Ala Ala 
            740                 745                 750         


Ser Ser Gln Leu Arg Leu Trp Lys Lys Gln Asn Asn Pro Leu Ile Ser 
        755                 760                 765             


Tyr Thr Glu Gly Gln Phe Val Asp Gln Val Thr Gly Glu Ile Ile Ser 
    770                 775                 780                 


Leu Ser Asp Asp Glu Tyr Lys Glu Leu Val Phe Lys Ala Pro Tyr Asp 
785                 790                 795                 800 


His Phe Val Asp Thr Leu Lys Ser Lys Lys Phe Glu Asp Ser Ile Leu 
                805                 810                 815     


Phe Ser Tyr Gln Val Asp Ser Lys Tyr Asn Arg Lys Ile Ser Asp Ala 
            820                 825                 830         


Thr Ile Tyr Ala Thr Arg Lys Ala Lys Leu Asp Lys Glu Asn Lys Glu 
        835                 840                 845             


Tyr Thr Tyr Thr Leu Gly Lys Ile Lys Asp Ile Tyr Ala Leu Gly Thr 
    850                 855                 860                 


Lys Ser Pro Ser Lys Thr Gly Phe Tyr Lys Phe Leu Asp Leu Tyr Asn 
865                 870                 875                 880 


Lys Asp Lys Ser Gln Phe Leu Met Phe Gln Lys Asp Arg Lys Thr Trp 
                885                 890                 895     


Asp Glu Val Ile Glu Lys Ile Ile Glu Gln Tyr Arg Pro Phe Lys Glu 
            900                 905                 910         


Tyr Asp Glu Asn Gly Lys Glu Val Asp Phe Asn Pro Phe Glu Lys Tyr 
        915                 920                 925             


Arg Ile Glu Asn Gly Pro Ile Arg Lys Tyr Ser Lys Lys Gly Asn Gly 
    930                 935                 940                 


Pro Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Asn Leu Leu Gly Lys Phe 
945                 950                 955                 960 


Val Asp Ile Thr Pro Ser Glu Ser Lys Asn Pro Val Ala Leu Leu Ser 
                965                 970                 975     


Leu Asn Pro Trp Arg Thr Asp Val Tyr Tyr Asn Thr Glu Thr Ser Lys 
            980                 985                 990         


Tyr Glu Phe Leu Gly Leu Lys Tyr  Ala Asp Leu Cys Phe  Glu Lys Gly 
        995                 1000                 1005             


Gly Ala  Tyr Gly Ile Ser Glu  Val Lys Tyr Asn Lys  Ile Arg Glu 
    1010                 1015                 1020             


Lys Glu  Gly Ile Gly Lys Glu  Ser Glu Phe Lys Phe  Thr Leu Tyr 
    1025                 1030                 1035             


Lys Asn  Asp Leu Ile Leu Ile  Lys Asp Thr Glu Thr  Asn Cys Gln 
    1040                 1045                 1050             


Gln Ile  Phe Arg Phe Trp Ser  Arg Thr Gly Lys Asp  Asn Pro Lys 
    1055                 1060                 1065             


Ser Phe  Glu Lys His Lys Ile  Glu Leu Lys Pro Tyr  Glu Lys Ala 
    1070                 1075                 1080             


Arg Phe  Glu Lys Gly Glu Glu  Leu Glu Val Leu Gly  Lys Val Pro 
    1085                 1090                 1095             


Pro Ser  Ser Asn Gln Leu Gln  Lys Asn Met Gln Ile  Glu Asn Leu 
    1100                 1105                 1110             


Ser Ile  Tyr Lys Val Lys Thr  Asp Val Leu Gly Asn  Lys His Phe 
    1115                 1120                 1125             


Ile Lys  Lys Glu Gly Glu Glu  Pro Lys Leu Lys Phe  
    1130                 1135                 1140 


<210> 554
<211> 1130
<212> PRT
<213> Streptococcus pasteurianus

<400> 554
Met Thr Asn Gly Lys Ile Leu Gly Leu Asp Ile Gly Ile Ala Ser Val 
1               5                   10                  15      


Gly Val Gly Ile Ile Glu Ala Lys Thr Gly Lys Val Val His Ala Asn 
            20                  25                  30          


Ser Arg Leu Phe Ser Ala Ala Asn Ala Glu Asn Asn Ala Glu Arg Arg 
        35                  40                  45              


Gly Phe Arg Gly Ser Arg Arg Leu Asn Arg Arg Lys Lys His Arg Val 
    50                  55                  60                  


Lys Arg Val Arg Asp Leu Phe Glu Lys Tyr Gly Ile Val Thr Asp Phe 
65                  70                  75                  80  


Arg Asn Leu Asn Leu Asn Pro Tyr Glu Leu Arg Val Lys Gly Leu Thr 
                85                  90                  95      


Glu Gln Leu Lys Asn Glu Glu Leu Phe Ala Ala Leu Arg Thr Ile Ser 
            100                 105                 110         


Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Glu Asp Asp Ser Thr 
        115                 120                 125             


Gly Ser Thr Asp Tyr Ala Lys Ser Ile Asp Glu Asn Arg Arg Leu Leu 
    130                 135                 140                 


Lys Asn Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Leu Glu Lys Tyr 
145                 150                 155                 160 


Gly Gln Leu Arg Gly Asn Phe Thr Val Tyr Asp Glu Asn Gly Glu Ala 
                165                 170                 175     


His Arg Leu Ile Asn Val Phe Ser Thr Ser Asp Tyr Glu Lys Glu Ala 
            180                 185                 190         


Arg Lys Ile Leu Glu Thr Gln Ala Asp Tyr Asn Lys Lys Ile Thr Ala 
        195                 200                 205             


Glu Phe Ile Asp Asp Tyr Val Glu Ile Leu Thr Gln Lys Arg Lys Tyr 
    210                 215                 220                 


Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg Phe 
225                 230                 235                 240 


Arg Thr Asp Gly Thr Thr Leu Glu Asn Ile Phe Gly Ile Leu Ile Gly 
                245                 250                 255     


Lys Cys Asn Phe Tyr Pro Asp Glu Tyr Arg Ala Ser Lys Ala Ser Tyr 
            260                 265                 270         


Thr Ala Gln Glu Tyr Asn Phe Leu Asn Asp Leu Asn Asn Leu Lys Val 
        275                 280                 285             


Ser Thr Glu Thr Gly Lys Leu Ser Thr Glu Gln Lys Glu Ser Leu Val 
    290                 295                 300                 


Glu Phe Ala Lys Asn Thr Ala Thr Leu Gly Pro Ala Lys Leu Leu Lys 
305                 310                 315                 320 


Glu Ile Ala Lys Ile Leu Asp Cys Lys Val Asp Glu Ile Lys Gly Tyr 
                325                 330                 335     


Arg Glu Asp Asp Lys Gly Lys Pro Asp Leu His Thr Phe Glu Pro Tyr 
            340                 345                 350         


Arg Lys Leu Lys Phe Asn Leu Glu Ser Ile Asn Ile Asp Asp Leu Ser 
        355                 360                 365             


Arg Glu Val Ile Asp Lys Leu Ala Asp Ile Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Glu Asp Ala Ile Lys Arg Asn Leu Pro Asn Gln Phe 
385                 390                 395                 400 


Thr Glu Glu Gln Ile Ser Glu Ile Ile Lys Val Arg Lys Ser Gln Ser 
                405                 410                 415     


Thr Ala Phe Asn Lys Gly Trp His Ser Phe Ser Ala Lys Leu Met Asn 
            420                 425                 430         


Glu Leu Ile Pro Glu Leu Tyr Ala Thr Ser Asp Glu Gln Met Thr Ile 
        435                 440                 445             


Leu Thr Arg Leu Glu Lys Phe Lys Val Asn Lys Lys Ser Ser Lys Asn 
    450                 455                 460                 


Thr Lys Thr Ile Asp Glu Lys Glu Val Thr Asp Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ala Lys Ser Val Arg Gln Thr Ile Lys Ile Ile Asn Ala Ala 
                485                 490                 495     


Val Lys Lys Tyr Gly Asp Phe Asp Lys Ile Val Ile Glu Met Pro Arg 
            500                 505                 510         


Asp Lys Asn Ala Asp Asp Glu Lys Lys Phe Ile Asp Lys Arg Asn Lys 
        515                 520                 525             


Glu Asn Lys Lys Glu Lys Asp Asp Ala Leu Lys Arg Ala Ala Tyr Leu 
    530                 535                 540                 


Tyr Asn Ser Ser Asp Lys Leu Pro Asp Glu Val Phe His Gly Asn Lys 
545                 550                 555                 560 


Gln Leu Glu Thr Lys Ile Arg Leu Trp Tyr Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Leu Tyr Ser Gly Lys Pro Ile Ser Ile Gln Glu Leu Val His Asn Ser 
            580                 585                 590         


Asn Asn Phe Glu Ile Asp His Ile Leu Pro Leu Ser Leu Ser Phe Asp 
        595                 600                 605             


Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ala Trp Thr Asn Gln Glu 
    610                 615                 620                 


Lys Gly Gln Lys Thr Pro Tyr Gln Val Ile Asp Ser Met Asp Ala Ala 
625                 630                 635                 640 


Trp Ser Phe Arg Glu Met Lys Asp Tyr Val Leu Lys Gln Lys Gly Leu 
                645                 650                 655     


Gly Lys Lys Lys Arg Asp Tyr Leu Leu Thr Thr Glu Asn Ile Asp Lys 
            660                 665                 670         


Ile Glu Val Lys Lys Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ser Arg Val Val Leu Asn Ser Leu Gln Ser Ala Leu Arg Glu 
    690                 695                 700                 


Leu Gly Lys Asp Thr Lys Val Ser Val Val Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg Arg Lys Trp Lys Ile Asp Lys Ser Arg Glu Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Lys 
            740                 745                 750         


Leu Trp Glu Lys Gln Asp Asn Pro Met Phe Val Asp Tyr Gly Lys Asn 
        755                 760                 765             


Gln Val Val Asp Lys Gln Thr Gly Glu Ile Leu Ser Val Ser Asp Asp 
    770                 775                 780                 


Glu Tyr Lys Glu Leu Val Phe Gln Pro Pro Tyr Gln Gly Phe Val Asn 
785                 790                 795                 800 


Thr Ile Ser Ser Lys Gly Phe Glu Asp Glu Ile Leu Phe Ser Tyr Gln 
                805                 810                 815     


Val Asp Ser Lys Tyr Asn Arg Lys Val Ser Asp Ala Thr Ile Tyr Ser 
            820                 825                 830         


Thr Arg Lys Ala Lys Ile Gly Lys Asp Lys Lys Glu Glu Thr Tyr Val 
        835                 840                 845             


Leu Gly Lys Ile Lys Asp Ile Tyr Ser Gln Asn Gly Phe Asp Thr Phe 
    850                 855                 860                 


Ile Lys Lys Tyr Asn Lys Asp Lys Thr Gln Phe Leu Met Tyr Gln Lys 
865                 870                 875                 880 


Asp Ser Leu Thr Trp Glu Asn Val Ile Glu Val Ile Leu Arg Asp Tyr 
                885                 890                 895     


Pro Thr Thr Lys Lys Ser Glu Asp Gly Lys Asn Asp Val Lys Cys Asn 
            900                 905                 910         


Pro Phe Glu Glu Tyr Arg Arg Glu Asn Gly Leu Ile Cys Lys Tyr Ser 
        915                 920                 925             


Lys Lys Gly Lys Gly Thr Pro Ile Lys Ser Leu Lys Tyr Tyr Asp Lys 
    930                 935                 940                 


Lys Leu Gly Asn Cys Ile Asp Ile Thr Pro Glu Glu Ser Arg Asn Lys 
945                 950                 955                 960 


Val Ile Leu Gln Ser Ile Asn Pro Trp Arg Ala Asp Val Tyr Phe Asn 
                965                 970                 975     


Pro Glu Thr Leu Lys Tyr Glu Leu Met Gly Leu Lys Tyr Ser Asp Leu 
            980                 985                 990         


Ser Phe Glu Lys Gly Thr Gly Asn  Tyr His Ile Ser Gln  Glu Lys Tyr 
        995                 1000                 1005             


Asp Ala  Ile Lys Glu Lys Glu  Gly Ile Gly Lys Lys  Ser Glu Phe 
    1010                 1015                 1020             


Lys Phe  Thr Leu Tyr Arg Asn  Asp Leu Ile Leu Ile  Lys Asp Ile 
    1025                 1030                 1035             


Ala Ser  Gly Glu Gln Glu Ile  Tyr Arg Phe Leu Ser  Arg Thr Met 
    1040                 1045                 1050             


Pro Asn  Val Asn His Tyr Val  Glu Leu Lys Pro Tyr  Asp Lys Glu 
    1055                 1060                 1065             


Lys Phe  Asp Asn Val Gln Glu  Leu Val Glu Ala Leu  Gly Glu Ala 
    1070                 1075                 1080             


Asp Lys  Val Gly Arg Cys Ile  Lys Gly Leu Asn Lys  Pro Asn Ile 
    1085                 1090                 1095             


Ser Ile  Tyr Lys Val Arg Thr  Asp Val Leu Gly Asn  Lys Tyr Phe 
    1100                 1105                 1110             


Val Lys  Lys Lys Gly Asp Lys  Pro Lys Leu Asp Phe  Lys Asn Asn 
    1115                 1120                 1125             


Lys Lys  
    1130 


<210> 555
<211> 1374
<212> PRT
<213> Streptococcus pseudoporcinus


<220>
<223> Streptococcus pseudoporcinus LQ 940-04

<400> 555
Met Lys Lys Arg Tyr Ser Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn 
1               5                   10                  15      


Ser Val Gly Trp Ala Val Ile Asn Glu Asp Tyr Lys Val Pro Ala Lys 
            20                  25                  30          


Lys Met Thr Val Phe Gly Asn Thr Asp Arg Lys Thr Ile Lys Lys Asn 
        35                  40                  45              


Leu Leu Gly Thr Val Leu Phe Asp Ser Gly Glu Thr Ala Gln Ala Arg 
    50                  55                  60                  


Arg Leu Lys Arg Thr Asn Arg Arg Arg Tyr Thr Arg Arg Arg Tyr Arg 
65                  70                  75                  80  


Leu Cys Gln Leu Gln Asn Ile Phe Ala Thr Glu Met Val Lys Val Asp 
                85                  90                  95      


Asp Thr Phe Phe Gln Arg Leu Ser Glu Ser Phe Phe Tyr Tyr Gln Asp 
            100                 105                 110         


Lys Ala Phe Asp Lys His Pro Ile Phe Gly Asn Ser Lys Glu Glu Arg 
        115                 120                 125             


Ala Tyr His Lys Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys Asp Leu 
    130                 135                 140                 


Ala Asp Arg Asp Gln Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu 
145                 150                 155                 160 


Ser His Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Leu 
                165                 170                 175     


Asn Ser Glu Asn Thr Asp Val Gln Lys Leu Phe Ile Ala Leu Val Thr 
            180                 185                 190         


Val Tyr Asn Leu Leu Phe Glu Glu Glu Pro Ile Ala Gly Glu Thr Cys 
        195                 200                 205             


Asp Ala Lys Ala Leu Leu Thr Ala Lys Thr Ser Lys Ser Lys Arg Leu 
    210                 215                 220                 


Glu Ser Leu Ile Ser Glu Phe Pro Gly Gln Lys Lys Asn Gly Leu Phe 
225                 230                 235                 240 


Gly Asn Leu Leu Ala Leu Ala Leu Gly Leu Arg Pro Asn Phe Lys Ser 
                245                 250                 255     


Asn Phe Gly Leu Ser Glu Asp Ala Lys Leu Gln Ile Thr Lys Asp Thr 
            260                 265                 270         


Tyr Glu Glu Glu Leu Asp Asn Leu Leu Ala Glu Ile Gly Asp His Tyr 
        275                 280                 285             


Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu 
    290                 295                 300                 


Ser Asp Ile Leu Thr Leu Ser Asp Glu Asn Thr Arg Ala Pro Leu Ser 
305                 310                 315                 320 


Ala Ser Met Ile Lys Arg Tyr Glu Glu His Gln Glu Asp Leu Ala Leu 
                325                 330                 335     


Leu Lys Lys Leu Val Lys Glu Gln Met Pro Glu Lys Tyr Trp Glu Ile 
            340                 345                 350         


Phe Ser Asn Ala Lys Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Gly Lys 
        355                 360                 365             


Val Ser Gln Glu Asp Phe Tyr Arg Tyr Ile Lys Pro Ile Leu Ser Arg 
    370                 375                 380                 


Leu Lys Gly Gly Asp Glu Phe Leu Ala Lys Ile Asp Arg Asp Asp Phe 
385                 390                 395                 400 


Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile 
                405                 410                 415     


His Leu Lys Glu Leu His Ala Ile Leu Arg Arg Gln Glu Lys Tyr Tyr 
            420                 425                 430         


Pro Phe Leu Ala Glu Gln Lys Glu Lys Ile Glu Gln Leu Leu Cys Phe 
        435                 440                 445             


Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Lys Gly Gly Asn Ser Ser 
    450                 455                 460                 


Phe Ala Trp Leu Lys Arg Arg Ser Asp Glu Pro Ile Thr Pro Trp Asn 
465                 470                 475                 480 


Phe Lys Asp Val Val Asp Glu Glu Ala Ser Ala Gln Ala Phe Ile Glu 
                485                 490                 495     


Gly Met Thr Asn Tyr Asp Thr Tyr Leu Pro Glu Glu Lys Val Leu Pro 
            500                 505                 510         


Lys His Ser Pro Leu Tyr Glu Met Phe Thr Val Tyr Asn Glu Leu Thr 
        515                 520                 525             


Lys Val Lys Tyr Ile Ala Glu Asn Met Thr Lys Pro Leu Tyr Leu Ser 
    530                 535                 540                 


Ala Glu Gln Lys Glu Ala Ile Ile Asp His Leu Phe Lys Gln Thr Arg 
545                 550                 555                 560 


Lys Val Thr Val Lys Asp Leu Lys Glu Lys Tyr Phe Ser Gln Ile Glu 
                565                 570                 575     


Gly Leu Glu Asn Val Asp Val Thr Gly Val Glu Gly Ala Phe Asn Ala 
            580                 585                 590         


Ser Leu Gly Thr Tyr Asn Asp Leu Leu Lys Ile Ile Lys Asp Lys Ala 
        595                 600                 605             


Phe Leu Asp Asp Glu Ala Asn Ala Glu Ile Leu Glu Glu Ile Val Leu 
    610                 615                 620                 


Ile Leu Thr Leu Phe Gln Asp Glu Lys Leu Ile Glu Lys Arg Leu Ala 
625                 630                 635                 640 


Lys Tyr Ala Asn Leu Phe Glu Lys Ser Val Leu Lys Lys Leu Arg Lys 
                645                 650                 655     


Arg His Tyr Arg Gly Trp Gly Arg Leu Ser Arg Gln Leu Ile Asp Gly 
            660                 665                 670         


Met Lys Asp Lys Ala Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ala 
        675                 680                 685             


Asp Asp Phe Ala Asn Arg Asn Phe Ile Gln Leu Ile Asn Asp Ser Ser 
    690                 695                 700                 


Leu Asp Phe Glu Lys Leu Ile Asp Asp Ala Gln Lys Lys Ala Ile Lys 
705                 710                 715                 720 


Arg Glu Ser Leu Thr Glu Ala Val Ala Asn Leu Ala Gly Ser Pro Ala 
                725                 730                 735     


Ile Lys Lys Gly Ile Leu Gln Ser Leu Lys Val Val Asp Glu Ile Val 
            740                 745                 750         


Lys Val Met Gly His Asn Pro Asp Asn Ile Val Ile Glu Met Ser Arg 
        755                 760                 765             


Glu Asn Gln Thr Thr Ala Gln Gly Leu Lys Asn Ala Arg Gln Arg Leu 
    770                 775                 780                 


Lys Lys Ile Lys Glu Val His Lys Lys Thr Gly Ser Arg Ile Leu Glu 
785                 790                 795                 800 


Asp Asn Ser Glu Arg Ile Thr Asn Leu Thr Leu Gln Asp Asn Arg Leu 
                805                 810                 815     


Tyr Leu Tyr Leu Leu Gln Asp Gly Lys Asp Met Tyr Thr Gly Gln Asp 
            820                 825                 830         


Leu Asp Ile Asn Asn Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ser Phe Ile Lys Asp Asn Ser Ile Asp Asn Leu Val Leu Thr Thr 
    850                 855                 860                 


Gln Lys Ala Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Ile Glu Val 
865                 870                 875                 880 


Val Arg Asp Met Lys Asp Arg Val Trp Arg Arg Gln Leu Ala Asn Gly 
                885                 890                 895     


Ala Ile Ser Arg Gln Lys Phe Asp His Leu Thr Lys Ala Glu Arg Gly 
            900                 905                 910         


Gly Leu Ala Asp Ser Asp Lys Ala Arg Phe Leu Arg Arg Gln Leu Val 
        915                 920                 925             


Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Leu Leu Asp Ser Arg 
    930                 935                 940                 


Phe Asn Ser Lys Ser Asn Gln Asn Lys Lys Leu Ala Arg Asn Val Lys 
945                 950                 955                 960 


Ile Ile Thr Leu Lys Ser Lys Ile Val Ser Asp Phe Arg Lys Asp Phe 
                965                 970                 975     


Gly Leu Tyr Lys Leu Arg Glu Val Asn Asn Tyr His His Ala His Asp 
            980                 985                 990         


Ala Tyr Leu Asn Ala Val Val Gly  Thr Ala Leu Leu Lys  Lys Tyr Pro 
        995                 1000                 1005             


Lys Leu  Glu Ala Glu Phe Val  Tyr Gly Asp Tyr Lys  His Phe Asp 
    1010                 1015                 1020             


Leu Val  Lys Leu Ile Ser Lys  Ser Asp Pro Ser Leu  Gly Lys Ala 
    1025                 1030                 1035             


Thr Ala  Lys Val Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1040                 1045                 1050             


Glu Glu  Leu Ser Leu Ala Asp  Gly Thr Leu Met Lys  Arg Pro Val 
    1055                 1060                 1065             


Ile Glu  Thr Asn Thr Glu Thr  Gly Glu Val Val Trp  Asp Lys Val 
    1070                 1075                 1080             


Lys Asp  Phe Lys Thr Ile Arg  Lys Val Leu Ser Tyr  Pro Gln Val 
    1085                 1090                 1095             


Asn Ile  Val Lys Lys Thr Glu  Ile Gln Ser Gly Ala  Phe Ser Lys 
    1100                 1105                 1110             


Glu Ser  Val Leu Ser Lys Gly  Asn Ser Asp Lys Leu  Ile Glu Arg 
    1115                 1120                 1125             


Lys Lys  Gly Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1130                 1135                 1140             


Asn Thr  Ala Tyr Ser Ile Phe  Val Val Ala Lys Val  Ala Lys Arg 
    1145                 1150                 1155             


Lys Ala  Gln Lys Leu Lys Thr  Val Lys Glu Ile Val  Gly Ile Thr 
    1160                 1165                 1170             


Ile Met  Glu Gln Ala Glu Tyr  Glu Lys Asp Asn Ile  Ala Phe Leu 
    1175                 1180                 1185             


Glu Lys  Lys Gly Tyr Gln Asp  Ile Gln Glu Lys Leu  Leu Ile Lys 
    1190                 1195                 1200             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Arg Arg 
    1205                 1210                 1215             


Leu Leu  Ala Ser Ala Asn Glu  Phe Gln Lys Gly Asn  Glu Leu Ala 
    1220                 1225                 1230             


Leu Ser  Gly Lys Tyr Met Lys  Phe Leu Tyr Leu Ala  Ser Arg Tyr 
    1235                 1240                 1245             


Asp Lys  Leu Ser Ser Lys Ile  Glu Ser Glu Gln Gln  Lys Lys Leu 
    1250                 1255                 1260             


Phe Val  Glu Gln His Leu His  Tyr Phe Asp Glu Ile  Leu Asp Ile 
    1265                 1270                 1275             


Val Val  Lys His Ala Thr Cys  Tyr Ile Lys Ala Glu  Asn Asn Leu 
    1280                 1285                 1290             


Lys Lys  Ile Ile Ser Leu Tyr  Lys Lys Lys Glu Ala  Tyr Ser Ile 
    1295                 1300                 1305             


Asn Glu  Gln Ala Leu Asn Met  Leu Asn Leu Phe Ile  Phe Thr Ser 
    1310                 1315                 1320             


Leu Gly  Ala Pro Ser Thr Phe  Val Phe Phe Asp Glu  Thr Ile Asp 
    1325                 1330                 1335             


Arg Lys  Arg Tyr Thr Thr Ser  Ser Asp Val Leu Asn  Gly Ile Leu 
    1340                 1345                 1350             


Ile Gln  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1355                 1360                 1365             


Ser Arg  Phe Gly Gly Asp 
    1370                 


<210> 556
<211> 1368
<212> PRT
<213> Streptococcus pyogenes


<220>
<223> Streptococcus pyogenes MGAS10270

<400> 556
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Leu Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Leu Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 557
<211> 1371
<212> PRT
<213> Streptococcus pyogenes

<400> 557
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Thr Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Lys Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Ile Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Ala Ile Gln Lys Ala Gln Val Ser Gly Gln Gly His Ser Leu 
705                 710                 715                 720 


His Glu Gln Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asp Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Arg  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Glu Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Ala Leu Thr  Asn Glu Ser Ile Tyr  Ala Arg Gly 
    1100                 1105                 1110             


Ser Phe  Asp Lys Leu Ile Ser  Arg Lys His Arg Phe  Glu Ser Ser 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Gly Ser  Pro Thr Val Thr Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Ser Lys Val  Gln Asp Gly Lys Val  Lys Lys Ile 
    1145                 1150                 1155             


Lys Thr  Gly Lys Glu Leu Ile  Gly Ile Thr Leu Leu  Asp Lys Leu 
    1160                 1165                 1170             


Val Phe  Glu Lys Asn Pro Leu  Lys Phe Ile Glu Asp  Lys Gly Tyr 
    1175                 1180                 1185             


Gly Asn  Val Gln Ile Asp Lys  Cys Ile Lys Leu Pro  Lys Tyr Ser 
    1190                 1195                 1200             


Leu Phe  Glu Phe Glu Asn Gly  Thr Arg Arg Met Leu  Ala Ser Val 
    1205                 1210                 1215             


Met Ala  Asn Asn Asn Ser Arg  Gly Asp Leu Gln Lys  Ala Asn Glu 
    1220                 1225                 1230             


Met Phe  Leu Pro Ala Lys Leu  Val Thr Leu Leu Tyr  His Ala His 
    1235                 1240                 1245             


Lys Ile  Glu Ser Ser Lys Glu  Leu Glu His Glu Ala  Tyr Ile Leu 
    1250                 1255                 1260             


Asp His  Tyr Asn Asp Leu Tyr  Gln Leu Leu Ser Tyr  Ile Glu Arg 
    1265                 1270                 1275             


Phe Ala  Ser Leu Tyr Val Asp  Val Glu Lys Asn Ile  Ser Lys Val 
    1280                 1285                 1290             


Lys Glu  Leu Phe Ser Asn Ile  Glu Ser Tyr Ser Ile  Ser Glu Ile 
    1295                 1300                 1305             


Cys Ser  Ser Val Ile Asn Leu  Leu Thr Leu Thr Ala  Ser Gly Ala 
    1310                 1315                 1320             


Pro Ala  Asp Phe Lys Phe Leu  Gly Thr Thr Ile Pro  Arg Lys Arg 
    1325                 1330                 1335             


Tyr Gly  Ser Pro Gln Ser Ile  Leu Ser Ser Thr Leu  Ile His Gln 
    1340                 1345                 1350             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu 
    1355                 1360                 1365             


Gly Ser  Asp 
    1370     


<210> 558
<211> 1367
<212> PRT
<213> Streptococcus pyogenes

<400> 558
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Gly Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Ile Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Arg Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Ala Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Gly Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly His Ser Leu 
705                 710                 715                 720 


His Glu Gln Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Ile Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg 
    1100                 1105                 1110             


Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Val Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser 
    1145                 1150                 1155             


Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe 
    1160                 1165                 1170             


Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu 
    1175                 1180                 1185             


Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    1190                 1195                 1200             


Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu 
    1205                 1210                 1215             


Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn 
    1220                 1225                 1230             


Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro 
    1235                 1240                 1245             


Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val Glu Gln  His Lys His 
    1250                 1255                 1260             


Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg 
    1265                 1270                 1275             


Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr 
    1280                 1285                 1290             


Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile 
    1295                 1300                 1305             


Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe 
    1310                 1315                 1320             


Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr 
    1325                 1330                 1335             


Lys Glu  Val Leu Asp Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly 
    1340                 1345                 1350             


Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln Leu Gly  Gly Asp 
    1355                 1360                 1365         


<210> 559
<211> 1368
<212> PRT
<213> Streptococcus sp.

<400> 559
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Ile Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Leu Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Leu Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Arg Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Thr Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Phe Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 560
<211> 1368
<212> PRT
<213> Streptococcus pyogenes

<400> 560
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Leu 
            20                  25                  30          


Lys Gly Leu Gly Asn Thr Asp Arg His Gly Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Val Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Thr Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Asp Ile Leu Lys Glu Tyr Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Val Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Arg Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asp Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Arg Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 561
<211> 1368
<212> PRT
<213> Streptococcus pyogenes

<400> 561
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 562
<211> 1368
<212> PRT
<213> Streptococcus pyogenes

<400> 562
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Leu Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asn Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Arg Lys Asp Leu Ile  Val Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Phe Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 563
<211> 1368
<212> PRT
<213> Streptococcus pyogenes

<400> 563
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Ile Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Leu Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Val Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Leu Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Arg Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Thr Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Phe Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 564
<211> 1368
<212> PRT
<213> Streptococcus pyogenes

<400> 564
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Ile Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Arg Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Leu Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Asp Ile Leu Lys Glu Tyr Pro 
785                 790                 795                 800 


Val Glu Thr Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Lys Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Arg Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Ile Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Val Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asp Pro Val Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Arg Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Cys Phe Asp Thr Thr  Ile Gly Arg Asn Arg  Tyr Lys Ser 
    1325                 1330                 1335             


Ile Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 565
<211> 1368
<212> PRT
<213> Streptococcus pyogenes


<220>
<223> Streptococcus pyogenes M1 GAS

<400> 565
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 566
<211> 1368
<212> PRT
<213> Streptococcus pyogenes

<400> 566
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Leu 
            20                  25                  30          


Lys Gly Leu Gly Asn Thr Asp Arg His Gly Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Val Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Thr Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Asp Ile Leu Lys Glu Tyr Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Val Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Arg Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asp Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Arg Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 567
<211> 1370
<212> PRT
<213> Streptococcus ratti


<220>
<223> Streptococcus ratti FA-1 = DSM 20564

<400> 567
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys Asn Tyr Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Leu Leu 
65                  70                  75                  80  


Tyr Leu Gln Asp Ile Phe Ser Asp Glu Met Asn Lys Val Asp Glu Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Ser Glu Asp Lys Arg 
            100                 105                 110         


Gly Asp His His Pro Ile Phe Gly Asn Val Val Asp Glu Val Lys Tyr 
        115                 120                 125             


His Glu Gln Phe Pro Thr Ile Tyr His Leu Arg Lys Tyr Leu Ala Asp 
    130                 135                 140                 


Thr Pro Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Asp Asp Pro Lys Leu Asp 
                165                 170                 175     


Val Lys Asn Thr Asp Ser Gln Glu Leu Phe Ser Gln Phe Leu Thr Ala 
            180                 185                 190         


Tyr Asp Val Thr Gln Glu Asp Ser His Leu Ala Asp Val Lys Ile Asn 
        195                 200                 205             


Ile Ser Asp Ile Ile Thr Glu Lys Met Asn Lys Ser Arg Lys Val Glu 
    210                 215                 220                 


Ala Leu Leu Phe His Phe Pro Ser Gln Lys Lys Asn Ser Phe Phe Gly 
225                 230                 235                 240 


Asn Leu Val Ser Leu Val Phe Gly Leu Leu Pro Asn Phe Lys Thr Asn 
                245                 250                 255     


Phe Asn Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Ser Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Glu Tyr Thr 
        275                 280                 285             


Asp Val Phe Val Ala Ala Arg Lys Leu Tyr Asp Ser Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Asn Asp Leu Ser Thr Lys Ala Ile Leu Ser Ala 
305                 310                 315                 320 


Ser Met Val Arg Arg Tyr Glu Glu His Asn Lys Asp Leu Ala Lys Leu 
                325                 330                 335     


Lys Ala Phe Val Lys Ala Asn Phe Thr His Asp Val Phe Lys Glu Val 
            340                 345                 350         


Phe Ser Asp Ala Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Gly Lys 
        355                 360                 365             


Thr Ser Gln Glu Asp Phe Tyr Lys Tyr Val Lys Asn Leu Ile Gly Lys 
    370                 375                 380                 


Val Asp Gly Ser Ala Asp Phe Ile Glu Lys Ile Asp Arg Glu Asp Phe 
385                 390                 395                 400 


Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Val 
                405                 410                 415     


His Leu Ala Glu Met Lys Ala Ile Leu Arg Arg Gln Gly Glu Tyr Tyr 
            420                 425                 430         


Pro Phe Leu Lys Glu His Ala Glu Lys Ile Gln Gln Ile Leu Thr Phe 
        435                 440                 445             


Arg Ile Pro Tyr Tyr Val Gly Pro Leu Asp Arg His Gly His Ser Asp 
    450                 455                 460                 


Phe Ala Trp Ala Ser Phe Asn Ser Glu Glu Lys Val Thr Pro Trp Asn 
465                 470                 475                 480 


Phe Glu Glu Ile Ile Asp Lys Asn Lys Ser Ala Gln Ala Phe Ile Glu 
                485                 490                 495     


Arg Met Thr Asn Gln Asp Leu Tyr Leu Pro Asn Glu Lys Val Leu Pro 
            500                 505                 510         


Lys His Ser Pro Leu Tyr Glu Lys Tyr Thr Val Tyr Asn Glu Leu Thr 
        515                 520                 525             


Lys Ile Lys Tyr Val Thr Glu Thr Gly Thr Ala Lys Phe Phe Asp Ala 
    530                 535                 540                 


Asn Leu Lys Gln Glu Ile Phe Asp Gly Leu Phe Lys Lys Glu Arg Lys 
545                 550                 555                 560 


Val Thr Lys Arg Lys Leu Leu Thr Phe Leu Glu Lys Asn Phe Asp Glu 
                565                 570                 575     


Phe Arg Ile Val Asp Ile Gln Gly Leu Asp Lys Glu Thr Glu Thr Phe 
            580                 585                 590         


Asn Ala Ser Tyr Gly Ile Tyr Gln Asp Leu Leu Lys Ile Ile Lys Asp 
        595                 600                 605             


Lys Ala Phe Met Asp Asp Ser Glu Asn Ala Asp Ile Leu Glu Asp Ile 
    610                 615                 620                 


Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Gln Arg 
625                 630                 635                 640 


Leu Ala Lys Tyr Ala Asp Leu Phe Asp Lys Lys Val Ile Asp Asn Leu 
                645                 650                 655     


Ala Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu 
            660                 665                 670         


Asn Gly Ile Arg Asp Lys Arg Ser Arg Lys Thr Ile Met Asp Tyr Leu 
        675                 680                 685             


Val Asp Asp Gly Arg Ser Asn Arg Asn Leu Met Gln Leu Ile Thr Asp 
    690                 695                 700                 


Asp Asn Leu Thr Phe Lys Asp Glu Ile Ala Lys Ala Gln Tyr Ser Asp 
705                 710                 715                 720 


Asn Ser Asp Asp Leu His Gln Val Val Gln Asp Leu Ala Gly Ser Pro 
                725                 730                 735     


Ala Ile Lys Lys Gly Ile Leu Gln Ser Val Lys Ile Val Asp Glu Leu 
            740                 745                 750         


Val Lys Val Met Gly Tyr Glu Pro Glu Gln Ile Val Val Glu Met Ala 
        755                 760                 765             


Arg Glu Asn Gln Thr Thr Ala Lys Gly Arg Arg Asn Ser Gln Gln Arg 
    770                 775                 780                 


Tyr Lys Arg Leu Glu Glu Ala Ile Lys Asn Leu Asp Arg Asp Leu Asn 
785                 790                 795                 800 


Tyr Lys Ile Leu Lys Glu His Pro Thr Asp Asn Gln Ala Leu Gln Asn 
                805                 810                 815     


Asp Arg Leu Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr 
            820                 825                 830         


Gly Glu Ser Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Ile Asp His 
        835                 840                 845             


Ile Ile Pro Gln Ala Phe Ile Lys Asp Asn Ser Ile Asp Asn Arg Val 
    850                 855                 860                 


Leu Val Ser Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser 
865                 870                 875                 880 


Glu Asp Val Val Asn Arg Met Arg Pro Phe Trp Asn Lys Leu Leu Asn 
                885                 890                 895     


Cys Gly Leu Ile Ser Gln Arg Lys Tyr Ser Asn Leu Thr Lys Lys Glu 
            900                 905                 910         


Leu Thr Pro Asn Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu His Phe 
    930                 935                 940                 


Asn Lys Glu Phe Asp Glu Asp Lys Lys Arg Ile Arg Lys Val Lys Val 
945                 950                 955                 960 


Val Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu 
                965                 970                 975     


Leu Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Leu Leu Met Lys  Tyr Pro Lys 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Glu Tyr Pro Lys  Tyr Asn Ser 
    1010                 1015                 1020             


Tyr Arg  Glu Arg Lys Thr Ala  Thr Gln Arg Met Phe  Phe Tyr Ser 
    1025                 1030                 1035             


Asn Ile  Met Asn Met Phe Lys  Ser Lys Val Lys Leu  Ala Asp Glu 
    1040                 1045                 1050             


Arg Ile  Ile Glu Arg Pro Met  Ile Glu Val Asn Asp  Glu Thr Gly 
    1055                 1060                 1065             


Glu Ile  Ala Trp Asp Lys Thr  Lys His Ile Ala Thr  Val Lys Lys 
    1070                 1075                 1080             


Val Leu  Ser Tyr Pro Gln Ile  Asn Ile Val Lys Lys  Val Glu Glu 
    1085                 1090                 1095             


Gln Thr  Gly Gly Leu Thr Asn  Glu Thr Ile Tyr Pro  Arg Gly Ser 
    1100                 1105                 1110             


Phe Asp  Lys Leu Leu Asn Arg  Lys Asn Thr Leu Glu  Ala Ser Lys 
    1115                 1120                 1125             


Tyr Gly  Gly Phe Gly Ser Pro  Thr Val Ala Tyr Cys  Val Leu Val 
    1130                 1135                 1140             


Val Ala  Asp Ser Lys Asn Glu  Asn Gly Lys Val Lys  Lys Leu Lys 
    1145                 1150                 1155             


Leu Gly  Ser Glu Leu Leu Gly  Ile Thr Ile Leu Glu  Lys Asn Asp 
    1160                 1165                 1170             


Phe Glu  Asn Asn Ser Leu Asp  Phe Leu Ser Arg Lys  Gly Tyr Gln 
    1175                 1180                 1185             


Gly Val  Gln Glu Lys Lys Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Phe Gln Asp Gly Ser  Arg Arg Met Leu Ser  Ser Val Met 
    1205                 1210                 1215             


Ala Asn  Asp Asn Lys Arg Gly  Asp Leu Gln Lys Ala  Asn Glu Met 
    1220                 1225                 1230             


Ile Leu  Pro Ala Tyr Leu Val  Lys Leu Leu Tyr His  Ala Lys His 
    1235                 1240                 1245             


Ile Asn  Ser Val Gly Glu Pro  Ala His Lys Asn Tyr  Ile Asn Glu 
    1250                 1255                 1260             


His Cys  Ser Glu Phe Gln Asp  Leu Leu Asn Tyr Ile  Arg Gln Phe 
    1265                 1270                 1275             


Ala Asp  Lys Phe Val Asp Val  Asp Lys Asn Leu Ser  Lys Ile Arg 
    1280                 1285                 1290             


Ser Leu  Ser Lys Ser Met Ala  Glu Tyr Ser Val Ser  Glu Ile Cys 
    1295                 1300                 1305             


Ser Ser  Phe Val Asn Leu Leu  Thr Leu Thr Ala Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Asp  Phe Lys Phe Phe Gly  Thr Thr Ile Pro Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Gly Ser  Pro Gln Ser Ile Leu  Ser Ala Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Lys Leu Gly 
    1355                 1360                 1365             


Glu Asp  
    1370 


<210> 568
<211> 1127
<212> PRT
<213> Streptococcus salivarius

<400> 568
Met Ser Asp Leu Val Leu Gly Leu Asp Ile Gly Ile Gly Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 
            20                  25                  30          


Arg Ile Phe Pro Ala Ala Gln Ala Glu Asn Asn Val Glu Arg Arg Ile 
        35                  40                  45              


Asn Arg Gln Gly Arg Arg Leu Thr Arg Arg Lys Lys His Arg Arg Val 
    50                  55                  60                  


Arg Leu Asn His Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 
65                  70                  75                  80  


Asn Val Ser Ile Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu 
                85                  90                  95      


Thr Asp Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 
            100                 105                 110         


Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 
        115                 120                 125             


Asn Ser Ser Val Gly Asp Tyr Ala Gln Ile Val Lys Glu Asn Ser Lys 
    130                 135                 140                 


Gln Leu Glu Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Tyr Gln 
145                 150                 155                 160 


Lys Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Glu Glu Asp Gly Lys 
                165                 170                 175     


Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr Arg Ala Glu 
            180                 185                 190         


Ala Leu Arg Ile Leu Gln Thr Gln Gln Glu Phe Asn Pro Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Asn Ser Tyr Leu Gln Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Tyr Thr Thr Lys Lys Asp Ser Glu Asp Glu Tyr Ile Thr Leu Asp Asn 
                245                 250                 255     


Ile Phe Gly Ile Leu Ile Gly Lys Cys Thr Phe Tyr Pro Glu Glu Tyr 
            260                 265                 270         


Arg Ala Ala Lys Ala Ser Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn 
        275                 280                 285             


Asp Leu Asn Asn Leu Thr Val Pro Thr Glu Thr Lys Lys Leu Ser Glu 
    290                 295                 300                 


Glu Gln Lys Asn Gln Ile Ile Thr Asn Val Lys Asn Glu Lys Ala Met 
305                 310                 315                 320 


Gly Pro Ala Lys Leu Phe Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp 
                325                 330                 335     


Val Ala Asp Ile Lys Gly Tyr Arg Ile Asp Lys Ser Asp Lys Ala Glu 
            340                 345                 350         


Ile His Thr Phe Glu Ala Tyr Arg Lys Met Lys Thr Leu Ala Thr Ile 
        355                 360                 365             


Asp Ile Glu Gln Met Glu Arg Glu Asn Leu Asp Lys Leu Ala Tyr Val 
    370                 375                 380                 


Leu Thr Leu Asn Thr Glu Lys Glu Gly Ile Gln Glu Ala Leu Glu His 
385                 390                 395                 400 


Glu Phe Ala Asp Gly Thr Phe Ser Gln Glu Gln Ile Asp Glu Leu Val 
                405                 410                 415     


Gln Phe Arg Lys Ala Asn Ser Ser Ile Phe Gly Lys Gly Trp His Ser 
            420                 425                 430         


Phe Ser Val Lys Leu Met Met Glu Leu Ile Pro Glu Leu Tyr Ala Thr 
        435                 440                 445             


Ser Glu Glu Gln Met Thr Ile Leu Thr Arg Leu Gly Lys Gln Lys Thr 
    450                 455                 460                 


Thr Ser Ser Ser Asn Lys Thr Lys Tyr Ile Asp Glu Lys Gln Leu Thr 
465                 470                 475                 480 


Glu Glu Ile Tyr Asn Pro Val Ala Ala Lys Ser Val Arg Gln Ala Ile 
                485                 490                 495     


Lys Ile Val Asn Ala Ala Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile 
            500                 505                 510         


Val Ile Glu Met Ala Arg Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala 
        515                 520                 525             


Ile Gln Lys Ile Gln Lys Ala Asn Lys Asp Glu Lys Asp Ala Ala Met 
    530                 535                 540                 


Leu Lys Ala Ala Asn Gln Tyr Asn Gly Lys Ala Glu Leu Pro His Ser 
545                 550                 555                 560 


Val Phe His Gly His Lys Gln Leu Ala Thr Lys Ile Arg Leu Trp His 
                565                 570                 575     


Gln Gln Gly Glu Arg Cys Leu Tyr Thr Gly Lys Thr Ile Ser Ile His 
            580                 585                 590         


Asp Leu Ile Asn Asn Ser Asn Gln Phe Glu Ile Asp His Ile Leu Pro 
        595                 600                 605             


Leu Ser Ile Thr Phe Asp Asp Ser Leu Ala Asn Lys Val Leu Val Tyr 
    610                 615                 620                 


Ala Thr Ala Asn Gln Glu Lys Gly Gln Arg Thr Pro Tyr Gln Ala Leu 
625                 630                 635                 640 


Asp Ser Met Asp Asp Ala Trp Ser Phe Arg Glu Leu Lys Ala Phe Val 
                645                 650                 655     


Arg Asp Ser Lys Ala Leu Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr 
            660                 665                 670         


Glu Glu Asp Ile Ser Lys Phe Asp Val Arg Lys Lys Phe Ile Glu Arg 
        675                 680                 685             


Asn Leu Val Asp Thr Arg Tyr Ala Ser Arg Val Val Leu Asn Ala Leu 
    690                 695                 700                 


Gln Glu His Phe Arg Val His Lys Thr Asp Thr Lys Val Ser Val Val 
705                 710                 715                 720 


Arg Gly Gln Phe Thr Ser Gln Leu Arg Arg His Trp Gly Ile Glu Lys 
                725                 730                 735     


Thr Arg Asp Thr Tyr His His His Ala Val Asp Ala Leu Ile Ile Ala 
            740                 745                 750         


Ala Ser Ser Gln Leu Asn Leu Trp Lys Lys Gln Lys Asn Thr Leu Val 
        755                 760                 765             


Ser Tyr Ser Glu Asp Gln Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile 
    770                 775                 780                 


Ser Asp Asp Glu Tyr Lys Glu Ser Val Phe Lys Ala Pro Tyr Gln His 
785                 790                 795                 800 


Phe Val Asp Thr Leu Lys Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe 
                805                 810                 815     


Ser Tyr Gln Val Asp Ser Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr 
            820                 825                 830         


Ile Tyr Ala Thr Arg Gln Ala Lys Val Gly Lys Asp Lys Lys Asp Glu 
        835                 840                 845             


Thr Tyr Val Leu Gly Lys Ile Lys Asp Ile Tyr Ser Gln Thr Gly Tyr 
    850                 855                 860                 


Asp Ala Phe Ile Lys Ile Tyr Lys Lys Asp Lys Ser Lys Phe Leu Met 
865                 870                 875                 880 


Tyr Arg His Asp Pro Gln Thr Phe Glu Lys Val Ile Glu Pro Ile Leu 
                885                 890                 895     


Glu Asn Tyr Pro Asn Lys Glu Leu Asn Glu Lys Gly Lys Glu Val Pro 
            900                 905                 910         


Cys Asn Pro Phe Leu Lys Tyr Lys Glu Asp His Gly Tyr Ile Arg Lys 
        915                 920                 925             


Tyr Ser Lys Lys Gly Asn Gly Pro Glu Ile Lys Ser Leu Lys Tyr Tyr 
    930                 935                 940                 


Asp Ser Lys Leu Gly Asn His Ile Asp Ile Thr Pro Lys Asn Ser Asn 
945                 950                 955                 960 


Asn Lys Val Val Leu Gln Ser Val Ser Pro Trp Arg Ala Asp Val Tyr 
                965                 970                 975     


Phe Asn Lys Thr Thr Gly Lys Tyr Glu Ile Leu Gly Leu Lys Tyr Ala 
            980                 985                 990         


Asp Leu Lys Phe Glu Lys Gly Thr  Gly Thr Tyr Lys Ile  Ser Glu Glu 
        995                 1000                 1005             


Lys Tyr  Asn Asp Ile Lys Ile  Lys Glu Gly Val Asp  Ser Asp Ser 
    1010                 1015                 1020             


Glu Phe  Lys Phe Thr Leu Tyr  Lys Asn Asp Leu Leu  Leu Ile Lys 
    1025                 1030                 1035             


Asp Thr  Glu Thr Lys Glu Gln  Gln Leu Phe Arg Phe  Leu Ser Arg 
    1040                 1045                 1050             


Thr Met  Pro Asn Val Lys His  Tyr Val Glu Leu Lys  Pro Tyr Asp 
    1055                 1060                 1065             


Lys Gln  Lys Phe Asp Asp Asn  Glu Glu Leu Ile Lys  Ile Leu Gly 
    1070                 1075                 1080             


Ile Val  Ala Lys Gly Gly Gln  Cys Lys Lys Gly Val  Ser Lys Pro 
    1085                 1090                 1095             


Asn Ile  Ser Ile Tyr Lys Ile  Arg Thr Asp Val Leu  Gly Asn Gln 
    1100                 1105                 1110             


His Ile  Ile Lys Asn Glu Gly  Asp Lys Pro Lys Leu  Asp Phe 
    1115                 1120                 1125         


<210> 569
<211> 1385
<212> PRT
<213> Streptococcus salivarius


<220>
<223> Streptococcus salivarius K12

<400> 569
Met Thr Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Ser Lys Lys Tyr Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Ile Thr Ala Glu Gly Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Thr Glu Met Ala Thr Leu Asp Asp Ala 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Pro Asp Asp Lys Arg 
            100                 105                 110         


Asp Ser Lys Tyr Pro Ile Phe Gly Asn Leu Val Glu Glu Lys Val Tyr 
        115                 120                 125             


His Asp Glu Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ser Ser Lys Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Asp Phe Asn Ser 
                165                 170                 175     


Lys Asn Asn Asp Leu Gln Lys Asn Phe Gln Asp Phe Leu Asp Thr Tyr 
            180                 185                 190         


Asn Ala Ile Phe Glu Ser Asp Leu Ser Leu Glu Asn Ser Lys Gln Leu 
        195                 200                 205             


Glu Glu Ile Val Lys Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 
    210                 215                 220                 


Ile Leu Lys Leu Phe Pro Gly Glu Lys Asn Ser Gly Ile Phe Ser Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Arg Lys Tyr Phe 
                245                 250                 255     


Asn Leu Asp Glu Lys Thr Ser Leu Gln Phe Ser Lys Glu Ser Tyr Asp 
            260                 265                 270         


Glu Asp Leu Glu Thr Leu Leu Gly His Ile Gly Asp Asp Tyr Ser Asp 
        275                 280                 285             


Val Phe Leu Lys Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Asn Gly Thr Glu Ala Pro Leu Ser Ser Ala 
305                 310                 315                 320 


Met Ile Met Arg Tyr Lys Glu His Glu Glu Asp Leu Ala Leu Leu Lys 
                325                 330                 335     


Ala Tyr Ile Arg Asn Ile Ser Leu Glu Thr Tyr Asn Glu Val Phe Lys 
            340                 345                 350         


Asp Asn Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Ser 
        355                 360                 365             


Gln Glu Asp Phe Tyr Val Tyr Leu Lys Arg Leu Leu Ala Gly Leu Glu 
    370                 375                 380                 


Gly Ala Asp Tyr Phe Leu Glu Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gln Ile Tyr Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Leu Asp Lys Gln Ala Lys Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Lys Asn Lys Glu Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Asp Phe Ala Trp 
    450                 455                 460                 


Ser Ile Arg Lys Arg Asn Glu Lys Ile Thr Pro Trp Asn Phe Glu Asp 
465                 470                 475                 480 


Val Ile Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Ser Phe Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Asn Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Arg 
        515                 520                 525             


Phe Ile Ala Glu Gly Met Arg Asp Tyr Gln Phe Leu Asp Ser Lys Gln 
    530                 535                 540                 


Lys Lys Asp Ile Val Arg Leu Tyr Phe Lys Gly Lys Arg Lys Val Thr 
545                 550                 555                 560 


Asp Lys Asp Ile Ile Glu Tyr Leu His Ala Ile Asp Gly Tyr Asp Gly 
                565                 570                 575     


Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ser Ser Leu Ser Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Asn Ile Ile Asn Asp Lys Glu Phe Leu Asp Asp 
        595                 600                 605             


Ser Ser Asn Glu Thr Ile Ile Glu Glu Ile Ile His Thr Leu Thr Met 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ser Lys Phe Asp Asn 
625                 630                 635                 640 


Ile Phe Asp Lys Ser Val Leu Lys Lys Leu Ser Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asp Glu 
            660                 665                 670         


Lys Ser Gly Asn Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Val Ser 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ala Leu Ser Phe Lys 
    690                 695                 700                 


Lys Lys Ile Lys Lys Ala Gln Ile Ile Gly Asp Lys Asp Asn Ile Lys 
705                 710                 715                 720 


Gln Val Val Lys Ser Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met Gly Arg 
            740                 745                 750         


Glu Pro Glu Ser Ile Val Val Glu Met Ala Arg Glu Asn Gln Tyr Thr 
        755                 760                 765             


Asn Gln Gly Lys Ser Asn Ser Gln Gln Arg Leu Lys Arg Leu Glu Glu 
    770                 775                 780                 


Ser Leu Lys Gly Leu Gly Ser Lys Ile Leu Lys Glu Asn Val Pro Thr 
785                 790                 795                 800 


Arg Leu Ser Lys Ile Asp Asn Asn Ala Leu Gln Asn Asp Arg Leu Tyr 
                805                 810                 815     


Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Glu Glu Leu 
            820                 825                 830         


Asp Ile Asp Arg Leu Ser Asn Tyr Asp Ile Asp His Ile Ile Pro Gln 
        835                 840                 845             


Ala Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Val Ser Ser 
    850                 855                 860                 


Ala Ser Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu Glu Val Val 
865                 870                 875                 880 


Lys Lys Arg Lys Thr Leu Trp Tyr Gln Leu Leu Lys Ser Lys Leu Ile 
                885                 890                 895     


Ser Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu 
            900                 905                 910         


Ser Gln Glu Glu Lys Ala Gly Phe Ile Gln Arg Gln Leu Val Glu Thr 
        915                 920                 925             


Arg Gln Ile Thr Lys His Val Ala Arg Leu Leu Asp Glu Arg Phe Asn 
    930                 935                 940                 


Asn Lys Lys Asp Glu Asn Asn Arg Thr Leu Arg Thr Val Lys Ile Ile 
945                 950                 955                 960 


Thr Leu Lys Ser Ser Leu Val Ser Gln Phe Arg Lys Asp Phe Glu Leu 
                965                 970                 975     


Tyr Lys Val Arg Glu Ile Asn Asp Phe His His Ala His Asp Ala Tyr 
            980                 985                 990         


Leu Asn Ala Val Val Ala Ser Ala  Leu Leu Lys Lys Tyr  Pro Lys Leu 
        995                 1000                 1005             


Glu Pro  Glu Phe Val Tyr Gly  Asp Tyr Pro Lys Tyr  Asn Ser Phe 
    1010                 1015                 1020             


Arg Glu  Arg Lys Ser Ala Thr  Glu Lys Val Tyr Phe  Tyr Ser Asn 
    1025                 1030                 1035             


Ile Met  Asn Ile Phe Lys Lys  Ser Ile Pro Leu Ala  Asp Gly Thr 
    1040                 1045                 1050             


Val Ile  Asp Arg Pro Leu Ile  Glu Val Asn Glu Glu  Thr Gly Glu 
    1055                 1060                 1065             


Ser Val  Trp Asn Lys Val Ala  Asp Leu Asn Thr Val  Arg Lys Val 
    1070                 1075                 1080             


Leu Ser  Tyr Ser Gln Val Asn  Ile Val Lys Lys Val  Glu Glu Gln 
    1085                 1090                 1095             


Asn His  Gly Leu Asp Arg Gly  Lys Pro Lys Gly Leu  Phe Asn Ala 
    1100                 1105                 1110             


Asn Leu  Ser Ser Lys Pro Lys  Pro Asn Ser Lys Glu  Asn Leu Val 
    1115                 1120                 1125             


Gly Ala  Lys Glu Tyr Leu Asp  Pro Lys Lys Tyr Gly  Gly Tyr Ala 
    1130                 1135                 1140             


Gly Ile  Ser Asn Ser Phe Ala  Ile Leu Val Lys Gly  Thr Ile Glu 
    1145                 1150                 1155             


Lys Gly  Ala Lys Lys Lys Ile  Thr Asn Val Leu Glu  Phe Gln Gly 
    1160                 1165                 1170             


Ile Ser  Ile Leu Asp Arg Ile  Tyr Tyr Arg Lys Asp  Lys Leu Asn 
    1175                 1180                 1185             


Phe Leu  Leu Glu Lys Gly Tyr  Lys Asp Ile Glu Leu  Ile Ile Glu 
    1190                 1195                 1200             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Ser Asp Gly  Ser Arg Arg 
    1205                 1210                 1215             


Met Leu  Ala Ser Ile Leu Ser  Thr Asn Asn Lys Arg  Gly Glu Ile 
    1220                 1225                 1230             


His Lys  Gly Asn Gln Ile Phe  Ile Ser Gln Lys Phe  Val Lys Leu 
    1235                 1240                 1245             


Leu Tyr  His Ala Lys Arg Ile  Ser Ser Thr Phe Asn  Glu Asn His 
    1250                 1255                 1260             


Arg Lys  Tyr Val Glu Asn His  Lys Lys Glu Phe Glu  Glu Leu Phe 
    1265                 1270                 1275             


Tyr Tyr  Ile Leu Glu Phe Asn  Glu Asn Tyr Val Gly  Ala Lys Lys 
    1280                 1285                 1290             


Asn Gly  Glu Leu Leu Lys Ser  Ala Phe Gln Ser Trp  Gln Asn His 
    1295                 1300                 1305             


Ser Ile  Asp Glu Leu Cys Ser  Ser Phe Ile Gly Pro  Thr Gly Ser 
    1310                 1315                 1320             


Glu Arg  Lys Gly Leu Phe Glu  Leu Thr Ser Arg Gly  Gly Ala Ala 
    1325                 1330                 1335             


Asp Phe  Glu Phe Leu Gly Val  Lys Ile Pro Arg Tyr  Arg Asp Tyr 
    1340                 1345                 1350             


Thr Pro  Ser Ser Leu Leu Lys  Asp Ala Thr Leu Ile  His Gln Ser 
    1355                 1360                 1365             


Val Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Gly  Lys Leu Gly 
    1370                 1375                 1380             


Glu Asp  
    1385 


<210> 570
<211> 1135
<212> PRT
<213> Streptococcus salivarius


<220>
<223> Streptococcus salivarius PS4

<400> 570
Met Ser Asp Leu Val Leu Gly Leu Asp Ile Gly Ile Gly Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 
            20                  25                  30          


Arg Ile Phe Pro Ala Ala Gln Ala Glu Asn Asn Leu Glu Arg Arg Thr 
        35                  40                  45              


Asn Arg Gln Gly Arg Arg Leu Thr Arg Arg Lys Lys His Arg Arg Val 
    50                  55                  60                  


Arg Leu Asn His Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 
65                  70                  75                  80  


Lys Val Ser Ile Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu 
                85                  90                  95      


Thr Ala Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 
            100                 105                 110         


Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 
        115                 120                 125             


Asn Ser Ser Val Gly Asp Tyr Ala Gln Ile Val Lys Glu Asn Ser Lys 
    130                 135                 140                 


Gln Leu Glu Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Tyr Gln 
145                 150                 155                 160 


Lys Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Glu Glu Asp Gly Arg 
                165                 170                 175     


Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr His Ala Glu 
            180                 185                 190         


Ala Leu Arg Ile Leu Gln Thr Gln Gln Glu Phe Asn Pro Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Asn Ser Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Lys 
225                 230                 235                 240 


Tyr Thr Thr Lys Lys Asp Ala Gln Gly Gln Tyr Ile Thr Leu Asn Asn 
                245                 250                 255     


Ile Phe Gly Ile Leu Ile Gly Lys Cys Thr Phe Tyr Pro Glu Glu Tyr 
            260                 265                 270         


Arg Ala Ala Lys Ala Ser Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn 
        275                 280                 285             


Asp Leu Asn Asn Leu Thr Val Pro Thr Glu Thr Lys Lys Leu Ser Glu 
    290                 295                 300                 


Glu Gln Lys Tyr Gln Ile Ile Thr Tyr Val Lys Asn Glu Lys Ala Met 
305                 310                 315                 320 


Gly Pro Ala Lys Leu Phe Lys Tyr Ile Ala Lys Leu Leu Ala Cys Asp 
                325                 330                 335     


Ile Ala Asp Ile Lys Gly Tyr Arg Ile Asp Lys Ser Asp Lys Ala Glu 
            340                 345                 350         


Ile His Thr Phe Glu Ala Tyr Arg Lys Met Lys Thr Leu Glu Thr Ile 
        355                 360                 365             


Asp Ile Glu Gln Ile Glu Arg Glu Lys Leu Asp Lys Leu Ala Tyr Val 
    370                 375                 380                 


Leu Thr Leu Asn Thr Glu Arg Glu Gly Ile Gln Glu Ala Leu Asp His 
385                 390                 395                 400 


Glu Phe Ala Asp Gly Thr Phe Ser Gln Glu Gln Val Asp Glu Leu Val 
                405                 410                 415     


Gln Phe Arg Lys Ala Asn Ser Ser Ile Phe Gly Lys Gly Trp His Ser 
            420                 425                 430         


Phe Ser Val Lys Leu Met Met Glu Leu Ile Pro Glu Leu Tyr Ala Thr 
        435                 440                 445             


Ser Glu Glu Gln Met Thr Ile Leu Thr Arg Leu Gly Lys Gln Lys Thr 
    450                 455                 460                 


Thr Ser Ser Ser Asn Lys Thr Lys Tyr Ile Asp Glu Lys Gln Leu Thr 
465                 470                 475                 480 


Glu Glu Ile Tyr Asn Pro Val Val Ala Lys Ser Val Arg Gln Ala Ile 
                485                 490                 495     


Lys Ile Val Asn Ala Ala Ile Lys Lys Tyr Gly Asp Phe Asp Asn Ile 
            500                 505                 510         


Val Ile Glu Met Ala Arg Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala 
        515                 520                 525             


Ile Gln Lys Ile Gln Lys Ala Asn Lys Ala Glu Lys Asp Ala Ala Met 
    530                 535                 540                 


Arg Lys Ala Ala Asn Gln Tyr Asn Gly Lys Ala Glu Leu Pro His Ser 
545                 550                 555                 560 


Val Phe His Gly His Lys Gln Leu Ala Thr Lys Ile Arg Leu Trp His 
                565                 570                 575     


Gln Gln Gly Glu Arg Cys Leu Tyr Thr Gly Lys Thr Ile Ser Ile His 
            580                 585                 590         


Asp Leu Ile Asn Asn Pro Asn Gln Phe Glu Ile Asp His Ile Leu Pro 
        595                 600                 605             


Leu Ser Ile Thr Phe Asp Asp Ser Leu Ala Asn Lys Val Leu Val Tyr 
    610                 615                 620                 


Ala Thr Ala Asn Gln Glu Lys Gly Gln Arg Thr Pro Tyr Gln Ala Leu 
625                 630                 635                 640 


Asp Ser Met Asp Asp Ala Trp Ser Phe Arg Glu Leu Lys Ala Phe Val 
                645                 650                 655     


Arg Glu Ser Lys Ala Leu Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr 
            660                 665                 670         


Glu Glu Asp Ile Ser Lys Phe Asp Val Arg Lys Lys Phe Ile Glu Arg 
        675                 680                 685             


Asn Leu Val Asp Thr Arg Tyr Ala Ser Arg Val Val Leu Asn Ala Leu 
    690                 695                 700                 


Gln Glu His Phe Lys Ala His Lys Ile Asp Thr Lys Val Ser Val Val 
705                 710                 715                 720 


Arg Gly Gln Phe Thr Ser Gln Leu Arg Arg His Trp Gly Ile Asp Lys 
                725                 730                 735     


Thr Arg Asp Thr Tyr His His His Ala Val Asp Ala Leu Ile Ile Ala 
            740                 745                 750         


Ala Ser Ser Gln Leu Asn Leu Trp Lys Lys Gln Lys Asn Thr Leu Val 
        755                 760                 765             


Ser Tyr Ser Glu Asp Gln Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile 
    770                 775                 780                 


Ser Asp Asp Glu Tyr Lys Glu Ser Val Phe Lys Ala Pro Tyr Gln His 
785                 790                 795                 800 


Phe Val Asp Thr Leu Lys Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe 
                805                 810                 815     


Ser Tyr Gln Val Asp Ser Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr 
            820                 825                 830         


Ile Tyr Ala Thr Arg Gln Ala Lys Val Gly Lys Asp Lys Lys Asp Glu 
        835                 840                 845             


Thr Tyr Val Leu Gly Lys Ile Lys Asp Ile Tyr Ala Leu Gly Thr Lys 
    850                 855                 860                 


Thr Pro Ser Lys Thr Gly Phe Tyr Lys Phe Leu Asp Leu Tyr Asn Lys 
865                 870                 875                 880 


Asp Lys Ser Gln Phe Leu Val Tyr Gln Lys Asp Arg Lys Thr Trp Asp 
                885                 890                 895     


Glu Val Ile Glu Lys Ile Met Glu Gln Tyr Arg Pro Phe Lys Glu Ser 
            900                 905                 910         


Asp Lys Asn Gly Lys Glu Val Asp Phe Asn Pro Phe Glu Lys Tyr Arg 
        915                 920                 925             


Ile Glu Asn Gly Pro Ile Arg Lys Tyr Ser Arg Lys Gly Asn Gly Pro 
    930                 935                 940                 


Glu Ile Lys Ser Leu Lys Tyr Tyr Ala Ser Lys Leu Gly Asn His Ile 
945                 950                 955                 960 


Asp Ile Thr Pro Lys Asp Ser Asn Asn Lys Val Val Leu Gln Ser Val 
                965                 970                 975     


Ser Pro Trp Arg Ala Asp Val Tyr Phe Asn Lys Thr Thr Gly Ser Tyr 
            980                 985                 990         


Glu Ile Leu Gly Leu Lys Tyr Ala  Asp Leu Gln Phe Glu  Lys Gly Thr 
        995                 1000                 1005             


Gly Thr  Tyr Arg Ile Ser Glu  Glu Lys Tyr Asn Asp  Ile Lys Lys 
    1010                 1015                 1020             


Lys Glu  Gly Val Asp Ser Asp  Ser Glu Phe Lys Phe  Thr Leu Tyr 
    1025                 1030                 1035             


Lys Asn  Asp Leu Leu Leu Ile  Lys Asp Thr Glu Thr  Lys Glu Gln 
    1040                 1045                 1050             


Arg Leu  Phe Arg Phe Leu Ser  Arg Ser Met Pro Asn  Lys Lys His 
    1055                 1060                 1065             


Tyr Val  Glu Leu Lys Pro Tyr  Ser Lys Asp Lys Phe  Glu Lys Asn 
    1070                 1075                 1080             


Glu Ser  Leu Ile Glu Ile Leu  Gly Ser Ala Asp Lys  Ser Gly Arg 
    1085                 1090                 1095             


Cys Ile  Lys Gly Leu Ala Lys  Ser Asn Leu Ser Ile  Phe Lys Val 
    1100                 1105                 1110             


Arg Thr  Asp Val Leu Gly Asn  Gln His Ile Ile Lys  Asn Glu Gly 
    1115                 1120                 1125             


Asp Lys  Pro Lys Leu Asp Phe  
    1130                 1135 


<210> 571
<211> 1377
<212> PRT
<213> Streptococcus sanguinis


<220>
<223> Streptococcus sanguinis SK115

<400> 571
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Lys His Phe Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Glu Gly Thr Thr Ala Glu Asp Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ser Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu Arg 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Glu Glu Ile Ser Lys Leu Asp Ser Ser 
                85                  90                  95      


Phe Phe His Arg Leu Asp Asp Ser Phe Leu Val Pro Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Glu Glu Glu Lys Glu Tyr 
        115                 120                 125             


His Lys Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 
    130                 135                 140                 


Ser Lys Glu Lys Thr Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Glu Ser Phe Asp Ile 
                165                 170                 175     


Lys Asn Asn Asp Ile Gln Lys Ile Phe Asn Glu Phe Ile Ser Ile Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Gly Ser Ser Leu Ser Gly Gln Asn Ala Gln Val 
        195                 200                 205             


Glu Ala Ile Phe Thr Asp Lys Ile Ser Lys Ser Thr Lys Arg Glu Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Ser Asp Glu Lys Ser Thr Gly Leu Phe Ser Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Asp Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Gly Phe Ala Asp 
        275                 280                 285             


Leu Phe Leu Val Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Pro Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Glu Arg Tyr Glu Asn His Gln Glu Asp Leu Ala Ala Leu Lys 
                325                 330                 335     


Gln Phe Ile Lys Asn Asn Leu Ser Glu Lys Tyr Ala Glu Val Phe Ser 
            340                 345                 350         


Asp Gln Ser Lys Asp Gly Tyr Ala Gly Phe Ile Asp Gly Lys Thr Thr 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Leu Glu 
    370                 375                 380                 


Gly Ala Asp Tyr Phe Leu Asn Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Asn Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Leu Phe 
            420                 425                 430         


Leu Lys Glu Asn Arg Glu Lys Ile Glu Lys Ile Leu Ala Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Arg Asp Phe Ala Trp 
    450                 455                 460                 


Leu Thr Arg Asn Ser Asp Gln Ala Ile Arg Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Ala Ser Ser Ala Glu Asp Phe Ile Asn Lys Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Phe Ile Ala Glu Gly Leu Arg Asp Tyr Gln Phe Leu Asp Ser Gly Gln 
    530                 535                 540                 


Lys Lys Gln Ile Val Asn Gln Leu Phe Lys Asp Lys Arg Lys Val Thr 
545                 550                 555                 560 


Glu Lys Asp Ile Ile His Tyr Leu His Asn Val Asp Gly Tyr Asp Gly 
                565                 570                 575     


Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Glu Phe Met Asp Asn 
        595                 600                 605             


Pro Lys Asn Gly Glu Ile Leu Glu Asn Ile Ile His Thr Leu Thr Ile 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Gln Tyr Asp Thr 
625                 630                 635                 640 


Leu Phe Asp Glu Lys Val Ile Lys Ala Leu Thr Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asp Lys 
            660                 665                 670         


Gln Thr Gly Lys Thr Ile Leu Glu Tyr Leu Ile Asp Asp Gly Asp Cys 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu Ser Phe Lys 
    690                 695                 700                 


Glu Ile Ile Gln Lys Ala Gln Val Val Gly Lys Thr Asp Asp Val Lys 
705                 710                 715                 720 


Gln Val Val Gln Glu Ile Pro Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met Gly His 
            740                 745                 750         


Asn Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr 
        755                 760                 765             


Ala Lys Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg Ile Glu Asp 
    770                 775                 780                 


Ala Leu Lys Asn Leu Ala Pro Gly Leu Asp Ser Asn Ile Leu Lys Glu 
785                 790                 795                 800 


Asn Pro Thr Asp Asn Ile Gln Leu Gln Asn Asp Arg Leu Phe Leu Tyr 
                805                 810                 815     


Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Lys Ala Ile Asp Ile 
            820                 825                 830         


Asn Gln Leu Ser Asn Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe 
        835                 840                 845             


Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser Ser Lys Asp 
    850                 855                 860                 


Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Ile Glu Val Val Gln Lys 
865                 870                 875                 880 


Arg Lys Ala Phe Trp Gln Gln Leu Leu Asp Ser Lys Leu Ile Ser Glu 
                885                 890                 895     


Arg Lys Phe Asn Asn Leu Thr Lys Ala Lys Arg Gly Gly Leu Asp Glu 
            900                 905                 910         


Arg Asp Lys Val Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln 
        915                 920                 925             


Ile Thr Lys His Val Ala Gln Leu Leu Asp Thr Arg Phe Asn Thr Glu 
    930                 935                 940                 


Val Asn Glu Glu Asn Gln Lys Ile Arg Thr Val Lys Ile Ile Thr Leu 
945                 950                 955                 960 


Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly Leu Tyr Lys 
                965                 970                 975     


Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn 
            980                 985                 990         


Ala Val Val Ala Lys Ala Ile Leu  Lys Lys Tyr Pro Lys  Leu Glu Pro 
        995                 1000                 1005             


Glu Phe  Val Tyr Gly Asp Tyr  Gln Lys Tyr Asp Leu  Lys Arg Tyr 
    1010                 1015                 1020             


Ile Leu  Lys Ser Lys Ala Ser  Asn Thr Ile Asp Lys  Ala Thr Glu 
    1025                 1030                 1035             


Lys Tyr  Phe Phe Tyr Ser Asn  Leu Leu Asn Phe Phe  Lys Glu Lys 
    1040                 1045                 1050             


Val Arg  Tyr Ala Asp Gly Thr  Ile Lys Lys Arg Glu  Asn Ile Glu 
    1055                 1060                 1065             


Tyr Ser  Asn Asp Thr Gly Glu  Ile Ala Trp Asn Lys  Glu Lys Asp 
    1070                 1075                 1080             


Phe Ala  Thr Ile Lys Lys Val  Leu Ser Leu Pro Gln  Val Asn Ile 
    1085                 1090                 1095             


Val Lys  Lys Thr Glu Glu Gln  Thr Val Gly Gln Asn  Gly Gly Leu 
    1100                 1105                 1110             


Phe Asp  Asn Asn Ile Val Ser  Lys Lys Lys Val Val  Asp Ala Ser 
    1115                 1120                 1125             


Lys Leu  Ile Pro Ile Lys Ser  Ser Leu Ser Pro Glu  Lys Tyr Gly 
    1130                 1135                 1140             


Gly Tyr  Ala Arg Pro Thr Ile  Ala Tyr Ser Val Leu  Val Ile Ala 
    1145                 1150                 1155             


Asp Ile  Glu Lys Gly Lys Gly  Lys Ala Lys Lys Leu  Lys Arg Ile 
    1160                 1165                 1170             


Lys Glu  Ile Val Gly Ile Thr  Ile Gln Asp Lys Lys  Lys Phe Glu 
    1175                 1180                 1185             


Ser Asn  Pro Val Thr Tyr Leu  Glu Glu Cys Gly Tyr  Lys Asn Ile 
    1190                 1195                 1200             


Asn Ser  Asn Leu Ile Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu 
    1205                 1210                 1215             


Phe Asn  Asp Gly Gln Arg Arg  Leu Leu Ala Ser Ser  Ile Glu Leu 
    1220                 1225                 1230             


Gln Lys  Gly Asn Glu Leu Ile  Leu Pro Tyr His Leu  Thr Ala Leu 
    1235                 1240                 1245             


Leu Tyr  His Ala Gln Arg Ile  Asn Lys Ile Ser Glu  Pro Ile His 
    1250                 1255                 1260             


Lys Gln  Tyr Val Glu Ala His  Gln Asn Glu Phe Lys  Glu Leu Leu 
    1265                 1270                 1275             


Thr Thr  Ile Ile Ser Leu Ser  Lys Lys Tyr Ile Gln  Lys Pro Asn 
    1280                 1285                 1290             


Val Glu  Leu Leu Leu Gln Gln  Ala Phe Asp Gln Ala  Asp Lys Asp 
    1295                 1300                 1305             


Ile Tyr  Gln Leu Ser Glu Ser  Phe Ile Ser Leu Leu  Lys Leu Thr 
    1310                 1315                 1320             


Ser Phe  Gly Ala Pro Gly Ala  Phe Lys Phe Leu Gly  Val Glu Ile 
    1325                 1330                 1335             


Ser Gln  Ser Ser Val Arg Tyr  Lys Pro Asn Ser Gln  Phe Leu Asp 
    1340                 1345                 1350             


Thr Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1355                 1360                 1365             


Ile Asp  Leu Ser Lys Leu Gly  Glu Asp 
    1370                 1375         


<210> 572
<211> 1392
<212> PRT
<213> Streptococcus sanguinis


<220>
<223> Streptococcus sanguinis SK330

<400> 572
Met Glu Asn Lys Asn Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys 
            20                  25                  30          


Met Lys Val Phe Gly Asn Thr Asp Lys His Phe Ile Lys Lys Asn Leu 
        35                  40                  45              


Ile Gly Ala Leu Leu Phe Asp Glu Gly Ala Thr Ala Glu Asp Arg Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ser Glu Glu Ile Ser Lys Leu Asp Ser 
                85                  90                  95      


Ser Phe Phe His Arg Leu Asp Asp Ser Phe Leu Val Pro Lys Asp Lys 
            100                 105                 110         


Arg Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Glu Glu Glu Lys Glu 
        115                 120                 125             


Tyr His Lys Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala 
    130                 135                 140                 


Asp Ser Lys Glu Lys Thr Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Glu Ser Phe Asp 
                165                 170                 175     


Ile Lys Asn Asn Asp Ile Gln Lys Ile Phe Asn Glu Phe Ile Ser Ile 
            180                 185                 190         


Tyr Asp Asn Thr Phe Glu Gly Ser Ser Leu Ser Gly Gln Asn Ala Gln 
        195                 200                 205             


Val Glu Ala Ile Phe Thr Asp Lys Ile Ser Lys Ser Ala Lys Arg Glu 
    210                 215                 220                 


Arg Val Leu Lys Leu Phe Ser Asp Glu Lys Ser Thr Ser Leu Phe Ser 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asp Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Gly Phe Thr 
        275                 280                 285             


Asp Leu Phe Leu Val Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Pro Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Glu Arg Tyr Glu Ser His Gln Lys Asp Leu Ala Ala Leu 
                325                 330                 335     


Lys Gln Phe Ile Lys Asn Asn Leu Pro Lys Arg Tyr Asn Glu Val Phe 
            340                 345                 350         


Ser Asp Gln Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr 
        355                 360                 365             


Thr Gln Glu Ala Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe 
    370                 375                 380                 


Glu Gly Ala Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met Asn Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Arg Asp Phe Ala 
    450                 455                 460                 


Trp Leu Thr Arg Asn Ser Asp Gln Ala Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Ile Val Asp Lys Ala Ser Ser Ala Glu Glu Phe Ile Asn Lys Met 
                485                 490                 495     


Thr Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Phe Ile Ala Glu Gly Leu Arg Asp Tyr Gln Phe Leu Asp Ser Gly 
    530                 535                 540                 


Gln Lys Lys Gln Ile Val Asn Gln Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile His Tyr Leu His Asn Val Asp Gly Tyr Asp 
                565                 570                 575     


Gly Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Glu Phe Met Asp 
        595                 600                 605             


Asp Pro Lys Asn Glu Glu Ile Leu Glu Asn Ile Val His Thr Leu Thr 
    610                 615                 620                 


Ile Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Gln Tyr Asp 
625                 630                 635                 640 


Ser Ile Phe Asp Glu Lys Val Ile Lys Ala Leu Thr Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Cys Asp 
            660                 665                 670         


Lys Gln Thr Gly Asp Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Lys 
        675                 680                 685             


Ile Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu Ser Phe 
    690                 695                 700                 


Lys Glu Ile Ile Gln Lys Ala Gln Val Val Gly Lys Thr Asp Asp Val 
705                 710                 715                 720 


Lys Gln Val Val Gln Glu Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Tyr Ala Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Ala Arg Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg Ile Glu 
    770                 775                 780                 


Asp Ser Leu Lys Asn Leu Ala Pro Gly Leu Asp Ser Asn Ile Leu Lys 
785                 790                 795                 800 


Glu Asn Pro Thr Asp Asn Ile Gln Leu Gln Asn Asp Arg Leu Phe Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Lys Pro Leu Asp 
            820                 825                 830         


Ile Asp Gln Leu Ser Ser Tyr Asp Ile Asp His Ile Ile Pro Gln Ala 
        835                 840                 845             


Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys 
    850                 855                 860                 


Asp Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Leu Glu Val Val Gln 
865                 870                 875                 880 


Lys Arg Lys Ala Phe Trp Gln Gln Leu Leu Asp Ser Lys Leu Ile Ser 
                885                 890                 895     


Glu Arg Lys Phe Asn Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Asp 
            900                 905                 910         


Glu Arg Asp Lys Val Gly Phe Ile Arg Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ala Ser Phe Asn Thr 
    930                 935                 940                 


Glu Val Asn Glu Lys Asn Gln Lys Ile Arg Thr Val Lys Ile Ile Thr 
945                 950                 955                 960 


Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr 
                965                 970                 975     


Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Ala Val Val Ala Lys Ala Ile  Leu Lys Lys Tyr Pro  Lys Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Asp  Tyr Gln Lys Tyr Asp  Leu Lys Arg 
    1010                 1015                 1020             


Tyr Ile  Ser Arg Phe Lys Pro  Ser Lys Glu Ile Glu  Lys Ala Thr 
    1025                 1030                 1035             


Glu Lys  Tyr Phe Phe Tyr Ser  Asn Leu Leu Asn Phe  Phe Lys Glu 
    1040                 1045                 1050             


Glu Val  His Tyr Ala Asp Gly  Ile Ile Val Lys Arg  Glu Asn Ile 
    1055                 1060                 1065             


Glu Tyr  Ser Lys Asp Thr Gly  Glu Ile Ala Trp Asn  Lys Glu Lys 
    1070                 1075                 1080             


Asp Phe  Ala Thr Ile Lys Lys  Val Leu Ser Tyr Pro  Gln Val Asn 
    1085                 1090                 1095             


Ile Val  Lys Lys Thr Glu Ile  Gln Thr His Gly Leu  Asp Arg Gly 
    1100                 1105                 1110             


Lys Pro  Lys Gly Leu Phe Asn  Ser Asn Pro Ser Pro  Lys Pro Ser 
    1115                 1120                 1125             


Glu Asp  Ser Lys Glu Asn Leu  Val Pro Ile Lys Gln  Gly Leu Asp 
    1130                 1135                 1140             


Pro Arg  Lys Tyr Gly Gly Tyr  Ala Gly Ile Ser Asn  Ser Tyr Ala 
    1145                 1150                 1155             


Val Leu  Val Lys Ala Ile Val  Glu Lys Gly Ala Lys  Lys Gln Gln 
    1160                 1165                 1170             


Lys Thr  Ile Leu Glu Phe Gln  Gly Ile Ser Ile Leu  Asp Lys Ile 
    1175                 1180                 1185             


Asn Phe  Glu Asn Asn Lys Glu  Asn Tyr Leu Leu Lys  Lys Arg Tyr 
    1190                 1195                 1200             


Ile Glu  Ile Leu Ser Thr Ile  Thr Leu Pro Lys Tyr  Ser Leu Phe 
    1205                 1210                 1215             


Glu Phe  Pro Asp Gly Thr Arg  Arg Arg Leu Ala Ser  Ile Leu Ser 
    1220                 1225                 1230             


Thr Asn  Asn Lys Arg Gly Glu  Ile His Lys Gly Asn  Glu Leu Val 
    1235                 1240                 1245             


Leu Pro  Gly Lys Tyr Thr Thr  Leu Leu Tyr His Ala  Lys Asn Ile 
    1250                 1255                 1260             


Asn Lys  Lys Leu Glu Pro Glu  His Leu Glu Tyr Val  Glu Lys His 
    1265                 1270                 1275             


Arg Asn  Asp Phe Ala Lys Leu  Leu Glu Cys Val Leu  Asn Phe Asn 
    1280                 1285                 1290             


Asp Lys  Tyr Val Gly Ala Leu  Lys Asn Gly Glu Arg  Ile Arg Gln 
    1295                 1300                 1305             


Ala Phe  Thr Asp Trp Glu Thr  Val Asp Ile Glu Lys  Leu Cys Phe 
    1310                 1315                 1320             


Ser Phe  Ile Gly Pro Glu Asn  Ser Lys Asn Ala Gly  Leu Phe Glu 
    1325                 1330                 1335             


Leu Thr  Ser Gln Gly Ser Ala  Ser Asp Phe Glu Phe  Leu Gly Val 
    1340                 1345                 1350             


Lys Ile  Pro Arg Tyr Arg Asp  Tyr Ala Pro Ser Ser  Leu Leu Lys 
    1355                 1360                 1365             


Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1370                 1375                 1380             


Ile Asp  Leu Ser Lys Leu Gly  Glu Asp 
    1385                 1390         


<210> 573
<211> 1370
<212> PRT
<213> Streptococcus sanguinis


<220>
<223> Streptococcus sanguinis SK353

<400> 573
Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 
            20                  25                  30          


Arg Val Phe Gly Asp Thr Asp Arg Ser His Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Thr Leu Leu Phe Asp Asp Gly Asn Thr Ala Glu Ser Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Thr Glu Ser Met Asn Glu Ile Asp Glu Ser 
                85                  90                  95      


Phe Phe His Arg Leu Asp Asp Ser Phe Leu Val Pro Glu Asp Lys Arg 
            100                 105                 110         


Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gln Glu Glu Lys Glu Tyr 
        115                 120                 125             


His Lys Gln Phe Pro Thr Ile Tyr His Leu Arg Lys Gln Leu Ala Asp 
    130                 135                 140                 


Ser Lys Glu Lys Ser Asp Val Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Glu Thr Phe Asp Ile 
                165                 170                 175     


Lys Asn Asn Asp Ile Gln Lys Ile Phe Asn Glu Phe Ile Asn Ile Tyr 
            180                 185                 190         


Asp Asn Thr Phe Glu Gly Ser Ser Leu Ser Gly Gln Asn Ala Gln Val 
        195                 200                 205             


Glu Ala Ile Phe Thr Asp Lys Ile Ser Lys Ser Ala Lys Arg Glu Arg 
    210                 215                 220                 


Val Leu Lys Leu Phe Pro Asp Glu Lys Ser Thr Gly Leu Phe Ser Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His Phe 
                245                 250                 255     


Asp Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Glu Glu Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Asp Phe Ala Asp 
        275                 280                 285             


Leu Phe Leu Ile Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Ile Leu Thr Val Thr Asp Pro Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Glu Arg Tyr Glu Asn His Gln Lys Asp Leu Ala Ala Leu Lys 
                325                 330                 335     


Gln Phe Ile Lys Asn Asn Leu Pro Glu Lys Tyr Val Glu Val Phe Ser 
            340                 345                 350         


Asp Gln Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Thr 
        355                 360                 365             


Gln Glu Ala Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe Glu 
    370                 375                 380                 


Gly Ala Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Asn Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Asp Asn Arg Asp Phe Ser Trp 
    450                 455                 460                 


Leu Thr Arg Asn Ser Asp Glu Pro Ile Arg Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Ala Arg Ser Ala Glu Asp Phe Ile His Arg Met Thr 
                485                 490                 495     


Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Phe Ile Ala Glu Gly Leu Arg Asp Tyr Gln Phe Leu Asp Ser Gly Gln 
    530                 535                 540                 


Lys Lys Gln Ile Val Asn Gln Leu Phe Lys Glu Lys Arg Lys Val Thr 
545                 550                 555                 560 


Glu Lys Asp Ile Ile His Tyr Leu His Asn Val Asp Gly Tyr Asp Gly 
                565                 570                 575     


Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Asn Leu Ser Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Lys Ile Thr Lys Asp Lys Glu Phe Met Asp Asp 
        595                 600                 605             


Pro Lys Asn Glu Glu Ile Leu Glu Asn Ile Val His Thr Leu Thr Ile 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Gln Tyr Asp Thr 
625                 630                 635                 640 


Leu Phe Asp Glu Lys Val Ile Lys Ala Leu Thr Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asp Lys 
            660                 665                 670         


Gln Ser Gly Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Asp Lys Ile 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu Ser Phe Lys 
    690                 695                 700                 


Glu Ile Ile Gln Lys Ala Gln Val Val Gly Lys Thr Asp Asp Val Lys 
705                 710                 715                 720 


Gln Val Val Gln Glu Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met Gly Tyr 
            740                 745                 750         


Ala Leu Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr 
        755                 760                 765             


Ala Arg Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg Ile Glu Asp 
    770                 775                 780                 


Ala Leu Lys Asn Leu Ala Pro Gly Leu Asp Ser Asn Ile Leu Lys Glu 
785                 790                 795                 800 


Asn Pro Thr Asp Asn Ile Gln Leu Lys Asn Asp Arg Leu Phe Leu Tyr 
                805                 810                 815     


Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Lys Pro Leu Asp Ile 
            820                 825                 830         


Asn Gln Leu Ser Ser Tyr Asp Ile Asp His Ile Ile Pro Gln Ala Phe 
        835                 840                 845             


Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Asp 
    850                 855                 860                 


Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Leu Glu Val Val Gln Lys 
865                 870                 875                 880 


Arg Lys Ala Phe Trp Gln Gln Leu Leu Asp Ser Lys Leu Ile Ser Glu 
                885                 890                 895     


Arg Lys Phe Asn Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Asp Glu 
            900                 905                 910         


Arg Asp Lys Val Gly Phe Ile Arg Arg Gln Leu Val Glu Thr Gln Gln 
        915                 920                 925             


Ile Thr Lys Asn Val Ala Gln Ile Leu Asp Ala Arg Phe Asn Thr Glu 
    930                 935                 940                 


Val Lys Glu Lys Asn Gln Lys Ile Arg Thr Val Lys Ile Ile Thr Leu 
945                 950                 955                 960 


Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Gly Leu Tyr Lys 
                965                 970                 975     


Val Arg Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn 
            980                 985                 990         


Ala Val Val Ala Lys Ala Ile Leu  Lys Lys Tyr Pro Lys  Leu Glu Pro 
        995                 1000                 1005             


Glu Phe  Val Tyr Gly Asp Tyr  Gln Lys Tyr Asp Leu  Lys Lys Tyr 
    1010                 1015                 1020             


Ile Ser  Arg Phe Lys Pro Ser  Lys Glu Ile Glu Lys  Ala Thr Glu 
    1025                 1030                 1035             


Lys Tyr  Phe Phe Tyr Ser Asn  Leu Leu Asn Phe Phe  Lys Glu Glu 
    1040                 1045                 1050             


Val Leu  Tyr Ala Asp Gly Thr  Ile Arg Lys Arg Glu  Asn Ile Glu 
    1055                 1060                 1065             


Tyr Ser  Lys Asp Thr Gly Glu  Ile Ala Trp Asp Lys  Glu Lys Asp 
    1070                 1075                 1080             


Phe Ala  Thr Ile Lys Lys Val  Leu Ser Tyr Pro Gln  Val Asn Ile 
    1085                 1090                 1095             


Val Lys  Lys Arg Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1100                 1105                 1110             


Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu Ile Pro  Arg Lys Thr 
    1115                 1120                 1125             


Lys Asp  Ile Leu Trp Asp Thr  Thr Lys Tyr Gly Gly  Phe Asp Ser 
    1130                 1135                 1140             


Pro Val  Ile Ala Tyr Ser Ile  Leu Leu Ile Ala Asp  Ile Glu Lys 
    1145                 1150                 1155             


Gly Lys  Ala Lys Lys Leu Lys  Thr Val Lys Thr Leu  Val Gly Ile 
    1160                 1165                 1170             


Thr Ile  Met Glu Lys Ala Ala  Phe Glu Glu Asn Pro  Ile Thr Phe 
    1175                 1180                 1185             


Leu Glu  Asn Lys Gly Tyr His  Asn Val Arg Lys Glu  Asn Ile Leu 
    1190                 1195                 1200             


Cys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Arg 
    1205                 1210                 1215             


Arg Leu  Leu Ala Ser Ala Lys  Glu Leu Gln Lys Gly  Asn Glu Ile 
    1220                 1225                 1230             


Val Leu  Pro Val Cys Leu Thr  Thr Leu Leu Tyr His  Ser Lys Asn 
    1235                 1240                 1245             


Leu His  Lys Leu Asp Glu Pro  Glu His Leu Glu Tyr  Ile Gln Lys 
    1250                 1255                 1260             


His Arg  Asn Glu Phe Lys Asp  Leu Leu Asn Leu Val  Ser Glu Phe 
    1265                 1270                 1275             


Ser Gln  Lys Tyr Ile Leu Ala  Glu Ala Asn Leu Glu  Lys Ile Lys 
    1280                 1285                 1290             


Asp Leu  Tyr Ala Asp Asn Glu  Gln Ala Asp Ile Glu  Ile Leu Ala 
    1295                 1300                 1305             


Asn Ser  Phe Ile Asn Leu Leu  Thr Phe Thr Ala Leu  Gly Ala Pro 
    1310                 1315                 1320             


Ala Ala  Phe Lys Phe Phe Gly  Lys Asp Val Asp Arg  Lys Arg Tyr 
    1325                 1330                 1335             


Thr Thr  Val Ser Glu Ile Leu  Asn Ala Thr Leu Ile  His Gln Ser 
    1340                 1345                 1350             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Lys Leu Gly 
    1355                 1360                 1365             


Glu Glu  
    1370 


<210> 574
<211> 1421
<212> PRT
<213> Streptococcus sanguinis


<220>
<223> Streptococcus sanguinis SK49

<400> 574
Met Thr Lys Phe Asn Lys Asn Tyr Ser Ile Gly Leu Asp Ile Gly Val 
1               5                   10                  15      


Ser Ser Val Gly Tyr Ala Val Val Thr Glu Asp Tyr Arg Val Pro Ala 
            20                  25                  30          


Phe Lys Phe Lys Val Leu Gly Asn Thr Glu Lys Glu Lys Ile Lys Lys 
        35                  40                  45              


Asn Leu Ile Gly Ser Thr Thr Phe Val Ser Ala Gln Pro Ala Lys Gly 
    50                  55                  60                  


Thr Arg Val Phe Arg Val Asn Arg Arg Arg Ile Asp Arg Arg Asn His 
65                  70                  75                  80  


Arg Ile Thr Tyr Leu Arg Asp Ile Phe Gln Lys Glu Ile Glu Lys Val 
                85                  90                  95      


Asp Lys Asn Phe Tyr Arg Arg Leu Asp Glu Ser Phe Arg Val Leu Gly 
            100                 105                 110         


Asp Lys Ser Glu Asp Leu Gln Ile Lys Gln Pro Phe Phe Gly Asp Lys 
        115                 120                 125             


Glu Leu Glu Thr Ala Tyr His Lys Lys Tyr Pro Thr Ile Tyr His Leu 
    130                 135                 140                 


Arg Lys His Leu Ala Asp Ala Asp Lys Asn Ser Pro Val Ala Asp Ile 
145                 150                 155                 160 


Arg Glu Val Tyr Met Ala Ile Ser His Ile Leu Lys Tyr Arg Gly His 
                165                 170                 175     


Phe Leu Thr Leu Asp Lys Ile Asn Pro Asn Asn Ile Asn Met Gln Asn 
            180                 185                 190         


Ser Trp Ile Asp Phe Ile Glu Ser Cys Gln Glu Val Phe Asp Leu Glu 
        195                 200                 205             


Ile Ser Asp Glu Ser Lys Asn Ile Ala Asp Ile Phe Lys Ser Ser Glu 
    210                 215                 220                 


Asn Arg Gln Glu Lys Val Lys Lys Ile Leu Pro Tyr Phe Gln Gln Glu 
225                 230                 235                 240 


Leu Leu Lys Lys Asp Lys Ser Ile Phe Lys Gln Leu Leu Gln Leu Leu 
                245                 250                 255     


Phe Gly Leu Lys Thr Lys Phe Lys Asp Cys Phe Glu Leu Glu Glu Glu 
            260                 265                 270         


Pro Asp Leu Asn Phe Ser Lys Glu Asn Tyr Asp Glu Asn Leu Glu Asn 
        275                 280                 285             


Phe Leu Gly Ser Leu Glu Glu Asp Phe Ser Asp Val Phe Ala Lys Leu 
    290                 295                 300                 


Lys Val Leu Arg Asp Thr Ile Leu Leu Ser Gly Met Leu Thr Tyr Thr 
305                 310                 315                 320 


Gly Ala Thr His Ala Arg Phe Ser Ala Thr Met Val Glu Arg Tyr Glu 
                325                 330                 335     


Glu His Arg Lys Asp Leu Gln Arg Phe Lys Phe Phe Ile Lys Gln Asn 
            340                 345                 350         


Leu Ser Glu Gln Asp Tyr Leu Asp Ile Phe Gly Arg Lys Thr Gln Asn 
        355                 360                 365             


Gly Phe Asp Val Asp Lys Glu Thr Lys Gly Tyr Val Gly Tyr Ile Thr 
    370                 375                 380                 


Asn Lys Met Val Leu Thr Asn Pro Gln Lys Gln Lys Thr Ile Gln Gln 
385                 390                 395                 400 


Asn Phe Tyr Asp Tyr Ile Ser Gly Lys Ile Thr Gly Ile Glu Gly Ala 
                405                 410                 415     


Glu Tyr Phe Leu Asn Lys Ile Ser Asp Gly Thr Phe Leu Arg Lys Leu 
            420                 425                 430         


Arg Thr Ser Asp Asn Gly Ala Ile Pro Asn Gln Ile His Ala Tyr Glu 
        435                 440                 445             


Leu Glu Lys Ile Ile Glu Arg Gln Gly Lys Asp Tyr Pro Phe Leu Leu 
    450                 455                 460                 


Glu Asn Lys Asp Lys Leu Leu Ser Ile Leu Thr Phe Lys Ile Pro Tyr 
465                 470                 475                 480 


Tyr Val Gly Pro Leu Ala Lys Gly Ser Asn Ser Arg Phe Ala Trp Ile 
                485                 490                 495     


Lys Arg Ala Thr Ser Ser Asp Ile Leu Asp Asp Asn Asp Glu Asp Thr 
            500                 505                 510         


Arg Asn Gly Lys Ile Arg Pro Trp Asn Tyr Gln Lys Leu Ile Asn Met 
        515                 520                 525             


Asp Glu Thr Arg Asp Ala Phe Ile Thr Asn Leu Ile Gly Asn Asp Ile 
    530                 535                 540                 


Ile Leu Leu Asn Glu Lys Val Leu Pro Lys Arg Ser Leu Ile Tyr Glu 
545                 550                 555                 560 


Glu Val Met Leu Gln Asn Glu Leu Thr Arg Val Lys Tyr Lys Asp Lys 
                565                 570                 575     


Tyr Gly Lys Ala His Phe Phe Asp Ser Glu Leu Arg Gln Asn Ile Ile 
            580                 585                 590         


Asn Gly Leu Phe Lys Asn Asn Ser Lys Arg Val Asn Ala Lys Ser Leu 
        595                 600                 605             


Ile Lys Tyr Leu Ser Asp Asn His Lys Asp Leu Asn Ala Ile Glu Ile 
    610                 615                 620                 


Val Ser Gly Val Glu Lys Gly Lys Ser Phe Asn Ser Thr Leu Lys Thr 
625                 630                 635                 640 


Tyr Asn Asp Leu Lys Thr Ile Phe Ser Glu Glu Leu Leu Asp Ser Glu 
                645                 650                 655     


Ile Tyr Gln Lys Glu Leu Glu Glu Ile Ile Lys Val Ile Thr Val Phe 
            660                 665                 670         


Asp Asp Lys Lys Ser Ile Lys Asn Tyr Leu Thr Lys Phe Phe Gly His 
        675                 680                 685             


Leu Glu Ile Leu Asp Glu Glu Lys Ile Asn Gln Leu Ser Lys Leu Arg 
    690                 695                 700                 


Tyr Ser Gly Trp Gly Arg Tyr Ser Ala Lys Leu Leu Leu Asp Ile Arg 
705                 710                 715                 720 


Asp Glu Asp Thr Gly Phe Asn Leu Leu Gln Phe Leu Arg Asn Asp Glu 
                725                 730                 735     


Glu Asn Arg Asn Leu Thr Lys Leu Ile Ser Asp Asn Thr Leu Ser Phe 
            740                 745                 750         


Glu Pro Lys Ile Lys Asp Ile Gln Ser Lys Ser Thr Ile Glu Asp Asp 
        755                 760                 765             


Ile Phe Asp Glu Ile Lys Lys Leu Ala Gly Ser Pro Ala Ile Lys Arg 
    770                 775                 780                 


Gly Ile Leu Asn Ser Ile Lys Ile Val Asp Glu Leu Val Gln Ile Ile 
785                 790                 795                 800 


Gly Tyr Pro Pro His Asn Ile Val Ile Glu Met Ala Arg Glu Asn Met 
                805                 810                 815     


Thr Thr Glu Glu Gly Gln Lys Lys Ala Lys Thr Arg Lys Thr Lys Leu 
            820                 825                 830         


Glu Ser Ala Leu Lys Asn Ile Glu Asn Ser Leu Leu Glu Asn Gly Lys 
        835                 840                 845             


Val Pro His Ser Asp Glu Gln Leu Gln Ser Glu Lys Leu Tyr Leu Tyr 
    850                 855                 860                 


Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Leu Asp Lys Thr Gly Ser 
865                 870                 875                 880 


Pro Ala Pro Leu Tyr Leu Asp Gln Leu Asp Gln Tyr Glu Val Asp His 
                885                 890                 895     


Ile Ile Pro Tyr Ser Phe Leu Pro Ile Asp Ser Ile Asp Asn Lys Val 
            900                 905                 910         


Leu Thr His Arg Glu Asn Asn Gln Gln Lys Leu Asn Asn Ile Pro Asp 
        915                 920                 925             


Lys Glu Thr Val Ala Asn Met Lys Pro Phe Trp Glu Lys Leu Tyr Asn 
    930                 935                 940                 


Ala Lys Leu Ile Ser Gln Thr Lys Tyr Gln Arg Leu Thr Thr Ser Glu 
945                 950                 955                 960 


Arg Thr Pro Asp Gly Val Leu Thr Glu Ser Met Lys Ala Gly Phe Ile 
                965                 970                 975     


Glu Arg Gln Leu Val Glu Thr Arg Gln Ile Ile Lys His Val Ala Arg 
            980                 985                 990         


Ile Leu Asp Asn Arg Phe Ser Asp  Thr Lys Ile Ile Thr  Leu Lys Ser 
        995                 1000                 1005             


Gln Leu  Ile Thr Asn Phe Arg  Asn Thr Phe His Ile  Ala Lys Ile 
    1010                 1015                 1020             


Arg Glu  Leu Asn Asp Tyr His  His Ala His Asp Ala  Tyr Leu Ala 
    1025                 1030                 1035             


Val Val  Val Gly Gln Thr Leu  Leu Lys Val Tyr Pro  Lys Leu Ala 
    1040                 1045                 1050             


Pro Glu  Leu Ile Tyr Gly His  His Ala His Phe Asn  Arg His Glu 
    1055                 1060                 1065             


Glu Asn  Lys Ala Thr Leu Arg  Lys His Leu Tyr Ser  Asn Ile Met 
    1070                 1075                 1080             


Arg Phe  Phe Asn Asn Pro Asp  Ser Lys Val Ser Lys  Asp Ile Trp 
    1085                 1090                 1095             


Asp Cys  Asn Arg Asp Leu Pro  Ile Ile Lys Asp Val  Ile Tyr Asn 
    1100                 1105                 1110             


Ser Gln  Ile Asn Phe Val Lys  Arg Thr Met Ile Lys  Lys Gly Ala 
    1115                 1120                 1125             


Phe Tyr  Asn Gln Asn Pro Val  Gly Lys Phe Asn Lys  Gln Leu Ala 
    1130                 1135                 1140             


Ala Asn  Asn Arg Tyr Pro Leu  Lys Thr Lys Ala Leu  Cys Leu Asp 
    1145                 1150                 1155             


Thr Ser  Ile Tyr Gly Gly Tyr  Gly Pro Met Asn Ser  Ala Leu Ser 
    1160                 1165                 1170             


Ile Ile  Ile Ile Ala Glu Arg  Phe Asn Glu Lys Lys  Gly Lys Ile 
    1175                 1180                 1185             


Glu Thr  Val Lys Glu Phe His  Asp Ile Phe Ile Ile  Asp Tyr Glu 
    1190                 1195                 1200             


Lys Phe  Asn Asn Asn Pro Phe  Gln Phe Leu Asn Asp  Thr Ser Glu 
    1205                 1210                 1215             


Asn Gly  Phe Leu Lys Lys Asn  Asn Ile Asn Arg Val  Leu Gly Phe 
    1220                 1225                 1230             


Tyr Arg  Ile Pro Lys Tyr Ser  Leu Met Gln Lys Ile  Asp Gly Thr 
    1235                 1240                 1245             


Arg Met  Leu Phe Glu Ser Lys  Ser Asn Leu His Lys  Ala Thr Gln 
    1250                 1255                 1260             


Phe Lys  Leu Thr Lys Thr Gln  Asn Glu Leu Phe Phe  His Met Lys 
    1265                 1270                 1275             


Arg Leu  Leu Thr Lys Ser Asn  Leu Met Asp Leu Lys  Ser Lys Ser 
    1280                 1285                 1290             


Ala Ile  Lys Glu Ser Gln Asn  Phe Ile Leu Lys His  Lys Glu Glu 
    1295                 1300                 1305             


Phe Asp  Asn Ile Ser Asn Gln  Leu Ser Ala Phe Ser  Gln Lys Met 
    1310                 1315                 1320             


Leu Gly  Asn Thr Thr Ser Leu  Lys Asn Leu Ile Lys  Gly Tyr Asn 
    1325                 1330                 1335             


Glu Arg  Lys Ile Lys Glu Ile  Asp Ile Arg Asp Glu  Thr Ile Lys 
    1340                 1345                 1350             


Tyr Phe  Tyr Asp Asn Phe Ile  Lys Met Phe Ser Phe  Val Lys Ser 
    1355                 1360                 1365             


Gly Ala  Pro Lys Asp Ile Asn  Asp Phe Phe Asp Asn  Lys Cys Thr 
    1370                 1375                 1380             


Val Ala  Arg Met Arg Pro Lys  Pro Asp Lys Lys Leu  Leu Asn Ala 
    1385                 1390                 1395             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1400                 1405                 1410             


Asp Leu  Ser Lys Leu Gly Glu  Asp 
    1415                 1420     


<210> 575
<211> 1026
<212> PRT
<213> Streptococcus sp.


<220>
<223> Streptococcus sp. BS35b

<400> 575
Met Asn Gly Leu Val Leu Gly Leu Asp Ile Gly Ile Ala Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Glu Lys Asn Ser Gly Lys Ile Ile His Ala Asn Ser 
            20                  25                  30          


Arg Leu Phe Pro Ala Ala Thr Ala Asp Asn Asn Val Glu Arg Arg Lys 
        35                  40                  45              


Asn Arg Gln Ala Arg Arg Leu Asn Arg Arg Lys Lys His Arg Gly Val 
    50                  55                  60                  


Arg Phe Gln Asp Leu Phe Glu Asp Tyr Gly Leu Leu Thr Asp Phe Ser 
65                  70                  75                  80  


Lys Val Ser Ile Asn Leu Asn Pro Tyr Arg Leu Arg Val Asp Gly Leu 
                85                  90                  95      


Asn Gln Gln Leu Thr Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Ile 
            100                 105                 110         


Val Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Glu Asp Gly 
        115                 120                 125             


Gly Ala Val Ser Ser Asp Tyr Gly Lys Ala Val Glu Glu Asn Arg Lys 
    130                 135                 140                 


Leu Leu Ala Glu Gln Thr Pro Gly Gln Ile Gln Leu Glu Arg Phe Glu 
145                 150                 155                 160 


Lys Tyr Gly Gln Val Arg Gly Asp Phe Thr Val Val Glu Asn Gly Glu 
                165                 170                 175     


Lys Arg Arg Leu Ile Asn Val Phe Ser Thr Ser Ala Tyr Arg Lys Glu 
            180                 185                 190         


Ala Glu Lys Ile Leu Arg Lys Gln Gln Glu Phe Asn Asn Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Glu Asp Tyr Leu Lys Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Phe Arg Thr Asp Gly Thr Thr Leu Asp Asn Ile Phe Gly Val Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Asn Glu Tyr Arg Ala Ser Lys Ser Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Glu Glu Gln Lys Lys Val Ile 
    290                 295                 300                 


Val Glu Tyr Ala Lys Glu Ala Lys Thr Leu Gly Ala Ser Thr Leu Leu 
305                 310                 315                 320 


Lys Tyr Ile Val Lys Met Ile Asp Ala Ser Val Asp Gln Ile Ser Gly 
                325                 330                 335     


Tyr Arg Val Asp Val Asn Asn Lys Pro Glu Met His Thr Phe Glu Val 
            340                 345                 350         


Tyr Arg Lys Met Gln Ser Leu Glu Thr Ile Ser Val Gly Glu Leu Ser 
        355                 360                 365             


Arg Asn Val Leu Asp Glu Leu Ala His Ile Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Glu Glu Ala Ile Asn Ser Lys Leu Met Gly Val Phe 
385                 390                 395                 400 


Ser Gln Asp Gln Val Leu Glu Leu Val Gln Phe Arg Lys Asn Asn Ser 
                405                 410                 415     


Ser Leu Phe Ser Lys Gly Trp His Asn Phe Ser Leu Lys Leu Met Met 
            420                 425                 430         


Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr Ile 
        435                 440                 445             


Leu Thr Arg Leu Gly Lys Gln Lys Ser Lys Glu Thr Ser Lys Arg Thr 
    450                 455                 460                 


Lys Tyr Ile Asp Glu Lys Glu Leu Thr Glu Glu Ile Tyr Asn Pro Val 
465                 470                 475                 480 


Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Ile Asn Glu Ala Thr 
                485                 490                 495     


Lys Lys His Gly Ile Phe Asp Asn Ile Val Ile Glu Met Ala Arg Glu 
            500                 505                 510         


Asn Asn Glu Glu Asp Ala Lys Lys Asp Tyr Ile Lys Arg Gln Lys Ala 
        515                 520                 525             


Asn Gln Asp Glu Lys Asn Ala Ala Met Glu Lys Ala Ala Phe Gln Tyr 
    530                 535                 540                 


Asn Gly Lys Lys Glu Leu Pro Gly Asn Ile Phe Asn Gly His Lys Glu 
545                 550                 555                 560 


Leu Ala Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Lys Cys Leu 
                565                 570                 575     


Tyr Thr Gly Lys Thr Ile Pro Ile Ser Asp Leu Ile His Asn Gln Tyr 
            580                 585                 590         


Lys Tyr Glu Ile Asp His Ile Leu Pro Leu Ser Leu Ser Phe Asp Asp 
        595                 600                 605             


Ser Leu Ser Asn Lys Val Leu Val His Ala Thr Ala Asn Gln Glu Lys 
    610                 615                 620                 


Gly Gln Arg Thr Pro Phe Gln Ala Leu Asp Ser Met Asp Asp Ala Trp 
625                 630                 635                 640 


Ser Tyr Arg Glu Phe Lys Ser Tyr Val Lys Asp Leu Lys Ser Leu Ser 
                645                 650                 655     


Asn Lys Lys Lys Asp Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys Ile 
            660                 665                 670         


Glu Val Lys Gln Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg Tyr 
        675                 680                 685             


Ser Ser Arg Val Val Leu Asn Ala Leu Gln Asp Phe Tyr Lys Ser His 
    690                 695                 700                 


Gln Phe Asp Thr Thr Ile Ser Val Val Arg Gly Gln Phe Thr Ser Gln 
705                 710                 715                 720 


Leu Arg Arg Lys Trp Gly Leu Glu Lys Ser Arg Glu Thr Tyr His His 
                725                 730                 735     


His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Arg Leu 
            740                 745                 750         


Trp Lys Lys Gln Asn Asn Pro Leu Ile Thr Tyr Lys Glu Gly Gln Phe 
        755                 760                 765             


Ile Asp Ser Gln Thr Gly Glu Ile Ile Ser Leu Thr Asp Asp Glu Tyr 
    770                 775                 780                 


Lys Glu Leu Val Phe Lys Ala Pro Tyr Asp His Phe Val Asp Thr Leu 
785                 790                 795                 800 


His Ser Lys Thr Phe Glu Asp Gly Ile Leu Phe Ser Tyr Gln Val Asp 
                805                 810                 815     


Ser Lys Tyr Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg 
            820                 825                 830         


Lys Ala Lys Leu Asp Lys Asp Lys Ser Glu Glu Thr Tyr Val Leu Gly 
        835                 840                 845             


Lys Ile Lys Asp Ile Tyr Ser Gln Ala Gly Tyr Asp Ala Phe Ile Lys 
    850                 855                 860                 


Ile Tyr Asn Lys Asp Lys Arg Lys Phe Leu Met Tyr His Lys Asp Pro 
865                 870                 875                 880 


Gln Thr Phe Glu Lys Val Ile Glu Glu Ile Leu Arg Thr Tyr Pro Ser 
                885                 890                 895     


Lys Glu Arg Asn Asp Lys Asn Lys Glu Val Pro Cys Asn Pro Phe Glu 
            900                 905                 910         


Lys Tyr Arg Gln Glu Asn Gly Pro Ile Arg Lys Tyr Ser Lys Lys Gly 
        915                 920                 925             


Asn Gly Pro Glu Ile Lys Cys Leu Lys Tyr Tyr Asp Asn Lys Leu Gly 
    930                 935                 940                 


Asn Tyr Ile Asp Ile Ser Pro Asp Gly Ser Asp Asn Gln Val Val Leu 
945                 950                 955                 960 


Gln Ser Leu Lys Pro Trp Arg Thr Asp Val Tyr Phe Asn His Gln Thr 
                965                 970                 975     


Lys Lys Tyr Glu Leu Met Gly Leu Lys Tyr Ser Asp Leu Ser Phe Glu 
            980                 985                 990         


Lys Gly Ser Gly Lys Tyr Ser Ile  Ser Asn Glu Lys Tyr  Asn Ser Ile 
        995                 1000                 1005             


Lys Arg  Ile Glu Gly Val Asn  Glu Gln Ser Glu Phe  Lys Phe Thr 
    1010                 1015                 1020             


Leu Tyr  Lys 
    1025     


<210> 576
<211> 1139
<212> PRT
<213> Streptococcus sp.


<220>
<223> Streptococcus sp. C150

<400> 576
Met Ser Asp Leu Val Leu Gly Leu Asp Ile Gly Ile Gly Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 
            20                  25                  30          


Arg Ile Phe Pro Ala Ala Gln Ala Glu Asn Asn Leu Glu Arg Arg Thr 
        35                  40                  45              


Asn Arg Gln Gly Arg Arg Leu Thr Arg Arg Lys Lys His Arg Arg Val 
    50                  55                  60                  


Arg Leu Asn His Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 
65                  70                  75                  80  


Lys Val Ser Ile Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu 
                85                  90                  95      


Thr Ala Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 
            100                 105                 110         


Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 
        115                 120                 125             


Asn Ser Ser Val Gly Asp Tyr Ala Gln Ile Val Lys Glu Asn Ser Lys 
    130                 135                 140                 


Gln Leu Glu Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Tyr Gln 
145                 150                 155                 160 


Lys Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Glu Glu Asp Gly Arg 
                165                 170                 175     


Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr His Ala Glu 
            180                 185                 190         


Ala Leu Arg Ile Leu Gln Thr Gln Gln Glu Phe Asn Pro Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Asn Ser Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Lys 
225                 230                 235                 240 


Tyr Thr Thr Lys Lys Asp Ala Gln Gly Gln Tyr Ile Thr Leu Asn Asn 
                245                 250                 255     


Ile Phe Gly Ile Leu Ile Gly Lys Cys Thr Phe Tyr Pro Glu Glu Tyr 
            260                 265                 270         


Arg Ala Ala Lys Ala Ser Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn 
        275                 280                 285             


Asp Leu Asn Asn Leu Thr Val Pro Thr Glu Thr Lys Lys Leu Ser Glu 
    290                 295                 300                 


Glu Gln Lys Tyr Gln Ile Ile Thr Tyr Val Lys Asn Glu Lys Ala Met 
305                 310                 315                 320 


Gly Pro Ala Lys Leu Phe Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp 
                325                 330                 335     


Val Ala Asp Ile Lys Gly Tyr Arg Ile Asp Lys Ser Asp Lys Ala Glu 
            340                 345                 350         


Ile His Thr Phe Glu Ala Tyr Arg Lys Met Lys Thr Leu Glu Thr Leu 
        355                 360                 365             


Asp Val Lys Lys Met Ala Arg Glu Glu Leu Asp Lys Leu Ala Tyr Val 
    370                 375                 380                 


Leu Thr Leu Asn Thr Glu Arg Glu Gly Ile Gln Glu Ala Leu Asp His 
385                 390                 395                 400 


Glu Phe Ala Asp Gly Thr Phe Ser Gln Glu Gln Val Asp Glu Leu Val 
                405                 410                 415     


Gln Phe Arg Lys Ala Asn Ser Ser Ile Phe Gly Lys Gly Trp His Ser 
            420                 425                 430         


Phe Ser Val Lys Leu Met Met Glu Leu Ile Pro Glu Leu Tyr Ala Thr 
        435                 440                 445             


Ser Glu Glu Gln Met Thr Ile Leu Thr Arg Leu Gly Lys Gln Lys Thr 
    450                 455                 460                 


Thr Ser Ser Ser Asn Lys Thr Lys Tyr Ile Asp Glu Lys Gln Leu Thr 
465                 470                 475                 480 


Glu Glu Ile Tyr Asn Pro Val Val Ala Lys Ser Val Arg Gln Ala Ile 
                485                 490                 495     


Lys Ile Val Asn Ala Ala Ile Lys Lys Tyr Gly Asp Phe Asp Asn Ile 
            500                 505                 510         


Val Ile Glu Met Ala Arg Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala 
        515                 520                 525             


Ile Gln Lys Ile Gln Lys Ala Asn Lys Ala Glu Lys Asp Ala Ala Met 
    530                 535                 540                 


Arg Lys Ala Ala Asn Gln Tyr Asn Gly Lys Ala Glu Leu Pro His Ser 
545                 550                 555                 560 


Val Phe His Gly His Lys Gln Leu Ala Thr Lys Ile Arg Leu Trp His 
                565                 570                 575     


Gln Gln Gly Glu Arg Cys Leu Tyr Thr Gly Lys Thr Ile Ser Ile His 
            580                 585                 590         


Asp Leu Ile Asn Asn Pro Asn Gln Phe Glu Ile Asp His Ile Leu Pro 
        595                 600                 605             


Leu Ser Ile Thr Phe Asp Asp Ser Leu Ala Asn Lys Val Leu Val Tyr 
    610                 615                 620                 


Ala Thr Ala Asn Gln Glu Lys Gly Gln Arg Thr Pro Tyr Gln Ala Leu 
625                 630                 635                 640 


Asp Ser Met Asp Asp Ala Trp Ser Phe Arg Glu Leu Lys Ala Phe Val 
                645                 650                 655     


Arg Glu Ser Lys Ala Leu Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr 
            660                 665                 670         


Glu Glu Asp Ile Ser Lys Phe Asp Val Arg Lys Lys Phe Ile Glu Arg 
        675                 680                 685             


Asn Leu Val Asp Thr Arg Tyr Ala Ser Arg Val Val Leu Asn Ala Leu 
    690                 695                 700                 


Gln Glu His Phe Arg Thr His Lys Ile Asp Thr Lys Val Ser Val Val 
705                 710                 715                 720 


Arg Gly Gln Phe Thr Ser Gln Leu Arg Arg His Trp Gly Ile Glu Lys 
                725                 730                 735     


Thr Arg Asp Thr Tyr His His His Ala Val Asp Ala Leu Ile Ile Ala 
            740                 745                 750         


Ala Ser Ser Gln Leu Asn Leu Trp Lys Lys Gln Lys Asn Thr Leu Val 
        755                 760                 765             


Ser Tyr Ser Glu Asp Gln Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile 
    770                 775                 780                 


Ser Asp Asp Glu Tyr Lys Glu Ser Val Phe Lys Ala Pro Tyr Gln His 
785                 790                 795                 800 


Phe Val Asp Thr Leu Lys Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe 
                805                 810                 815     


Ser Tyr Gln Val Asp Ser Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr 
            820                 825                 830         


Ile Tyr Ala Thr Arg Lys Ala Lys Leu Asp Lys Glu Lys Lys Glu Tyr 
        835                 840                 845             


Thr Tyr Thr Leu Gly Lys Ile Lys Asp Ile Tyr Ala Leu Gly Thr Lys 
    850                 855                 860                 


Thr Pro Ser Lys Thr Gly Phe Tyr Lys Phe Leu Asp Leu Tyr Lys Lys 
865                 870                 875                 880 


Asp Lys Ser Gln Phe Leu Met Tyr Gln Lys Asp Arg Arg Thr Trp Asp 
                885                 890                 895     


Glu Val Ile Glu Lys Ile Leu Glu Gln Tyr Arg Pro Phe Lys Glu Lys 
            900                 905                 910         


Asp Lys Asn Gly Lys Glu Val Asp Phe Asn Pro Phe Glu Lys Tyr Arg 
        915                 920                 925             


Ile Glu Asn Gly Pro Ile Arg Lys Tyr Ser Arg Lys Gly Asn Gly Pro 
    930                 935                 940                 


Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Asn Leu Leu Gly Arg Phe Val 
945                 950                 955                 960 


Asp Ile Thr Pro Ser Glu Ser Lys Asn Pro Val Ala Leu Leu Ser Leu 
                965                 970                 975     


Asn Pro Trp Arg Thr Asp Val Tyr Tyr Asn Thr Glu Thr Arg Lys Tyr 
            980                 985                 990         


Glu Phe Leu Gly Leu Lys Tyr Ala  Asp Leu Cys Phe Glu  Lys Gly Gly 
        995                 1000                 1005             


Ser Tyr  Gly Ile Ser Lys Val  Lys Tyr Asn Lys Ile  Arg Glu Lys 
    1010                 1015                 1020             


Glu Gly  Ile Gly Lys Asn Ser  Glu Phe Lys Phe Thr  Leu Tyr Lys 
    1025                 1030                 1035             


Asn Asp  Leu Ile Leu Ile Lys  Asp Thr Glu Thr Asn  Arg Gln Gln 
    1040                 1045                 1050             


Ile Phe  Arg Phe Trp Ser Arg  Thr Gly Lys Asp Asn  Pro Lys Ser 
    1055                 1060                 1065             


Phe Glu  Lys His Lys Leu Glu  Leu Lys Pro Tyr Glu  Lys Thr Arg 
    1070                 1075                 1080             


Phe Glu  Lys Gly Glu Glu Leu  Lys Val Leu Gly Lys  Val Pro Pro 
    1085                 1090                 1095             


Ser Ser  Asn Arg Leu Gln Lys  Asn Met Gln Ile Glu  Asn Leu Ser 
    1100                 1105                 1110             


Ile Tyr  Lys Val Arg Thr Asp  Val Leu Gly Asn Gln  His Ile Ile 
    1115                 1120                 1125             


Lys Asn  Glu Gly Asp Lys Pro  Lys Leu Asp Phe 
    1130                 1135                 


<210> 577
<211> 1377
<212> PRT
<213> Streptococcus sp.


<220>
<223> Streptococcus sp. C300

<400> 577
Met Asn Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ser Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys Arg Phe Ile Lys Lys Asn Leu 
        35                  40                  45              


Ile Gly Ala Leu Leu Phe Asp Glu Gly Thr Thr Ala Glu Ala Arg Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Ser 
                85                  90                  95      


Ser Phe Phe His Arg Leu Asp Asp Ser Phe Leu Ile Pro Glu Asp Lys 
            100                 105                 110         


Arg Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Val Glu Glu Lys Glu 
        115                 120                 125             


Tyr His Lys Gln Phe Pro Thr Ile Tyr His Leu Arg Lys Gln Leu Ala 
    130                 135                 140                 


Asp Ser Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Val Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Glu Ala Phe Asp 
                165                 170                 175     


Ile Lys Asn Asn Asp Ile Gln Lys Ile Phe Asn Glu Phe Ile Ser Ile 
            180                 185                 190         


Tyr Asp Asn Thr Phe Glu Gly Ser Ser Leu Ser Gly Gln Asn Ala Gln 
        195                 200                 205             


Val Glu Thr Ile Phe Thr Asp Lys Ile Ser Lys Ser Ala Lys Arg Glu 
    210                 215                 220                 


Arg Val Leu Lys Leu Phe Pro Asp Glu Lys Ser Thr Gly Leu Phe Ser 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asp Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Glu Gln Ile Gly Asp Asp Phe Ala 
        275                 280                 285             


Asp Leu Phe Val Ala Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Pro Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Glu Arg Tyr Glu Asn His Gln Lys Asp Leu Ala Val Leu 
                325                 330                 335     


Lys Gln Phe Ile Lys Thr Asn Leu Pro Glu Lys Tyr Val Glu Val Phe 
            340                 345                 350         


Ser Asp Gln Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr 
        355                 360                 365             


Thr Gln Glu Ala Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe 
    370                 375                 380                 


Asp Gly Ala Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Val Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met Asn Thr Ile Leu Arg Arg Gln Gly Glu His Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Lys Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr His Val Gly Pro Leu Ala Arg Gly Asn Arg Asp Phe Ala 
    450                 455                 460                 


Trp Leu Thr Arg Asn Ser Asp Gln Ala Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Ile Val Asp Lys Ala Ser Ser Ala Glu Asp Phe Ile Asn Lys Met 
                485                 490                 495     


Thr Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Phe Ile Ala Glu Gly Met Arg Asp Tyr Gln Phe Leu Asp Ser Gly 
    530                 535                 540                 


Gln Lys Lys Lys Ile Ile Asn Gln Leu Phe Lys Lys Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Asp Asp Ile Ile Asp Cys Leu Gln Lys Ile Asp Asn Tyr Asp 
                565                 570                 575     


Gly Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Ile Leu Lys Ile Ile Arg Asp Lys Glu Phe Met Asp 
        595                 600                 605             


Asp Pro Lys Asn Gly Asp Ile Leu Glu Asn Val Ile His Thr Leu Thr 
    610                 615                 620                 


Ile Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Gln Tyr Asn 
625                 630                 635                 640 


Ser Ile Phe Asp Glu Lys Val Ile Lys Ala Leu Ser Arg Lys His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asp Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Thr Gly Lys Thr Ile Leu Asp Tyr Leu Met Asp Asp Gly Lys 
        675                 680                 685             


Ser Asn Arg Asn Phe Met Gln Leu Ile Lys Asp Asp Glu Leu Ser Phe 
    690                 695                 700                 


Thr Glu Ile Ile Gln Lys Ala Gln Val Val Gly Asp Thr Asp Asn Leu 
705                 710                 715                 720 


Arg Gln Val Val Gln Asn Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Ala Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Ala Arg Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg Ile Glu 
    770                 775                 780                 


Asp Ser Leu Lys Asn Leu Ala Ser Gly Leu Asp Ser Asn Ile Leu Lys 
785                 790                 795                 800 


Glu Asn Pro Thr Asp Asn Ile Gln Leu Gln Asn Asp Arg Leu Phe Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Glu Ala Leu Asn 
            820                 825                 830         


Ile Asn Gln Leu Ser Ser Tyr Asp Ile Asp His Ile Ile Pro Gln Ala 
        835                 840                 845             


Phe Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser Ser Lys 
    850                 855                 860                 


Asp Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Leu Glu Val Val Glu 
865                 870                 875                 880 


Lys Met Lys Ala Phe Trp Gln Gln Leu Leu Asp Ser Lys Leu Ile Ser 
                885                 890                 895     


Glu Arg Lys Tyr Asn Asn Leu Thr Lys Ala Glu Arg Glu Arg Gly Gly 
            900                 905                 910         


Leu Asn Glu Leu Asp Lys Val Gly Phe Ile Lys Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ala Arg Phe 
    930                 935                 940                 


Asn Lys Glu Val Thr Glu Lys Asn Lys Lys Asn Arg Asn Val Lys Ile 
945                 950                 955                 960 


Ile Thr Leu Lys Ser Asn Met Val Ser Asn Phe Arg Lys Glu Phe Gly 
                965                 970                 975     


Leu Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala 
            980                 985                 990         


Tyr Leu Asn Ala Val Val Ala Lys  Ala Ile Leu Lys Lys  Tyr Pro Lys 
        995                 1000                 1005             


Leu Glu  Pro Glu Phe Val Tyr  Gly Asp Tyr Gln Lys  Tyr Asp Leu 
    1010                 1015                 1020             


Lys Arg  Tyr Ile Ser Arg Ser  Lys Asp Pro Lys Glu  Val Glu Lys 
    1025                 1030                 1035             


Ala Thr  Glu Lys Tyr Phe Phe  Tyr Ser Asn Leu Leu  Asn Phe Phe 
    1040                 1045                 1050             


Lys Glu  Glu Val His Tyr Ala  Asp Gly Thr Ile Val  Lys Arg Glu 
    1055                 1060                 1065             


Asn Ile  Glu Tyr Ser Lys Asp  Thr Gly Glu Ile Ala  Trp Asn Lys 
    1070                 1075                 1080             


Glu Lys  Asp Phe Ala Thr Ile  Lys Lys Val Leu Ser  Leu Pro Gln 
    1085                 1090                 1095             


Val Asn  Ile Val Lys Lys Thr  Glu Glu Gln Thr Val  Gly Gln Asn 
    1100                 1105                 1110             


Gly Gly  Leu Phe Asp Asn Asn  Ile Val Ser Lys Lys  Lys Val Val 
    1115                 1120                 1125             


Asp Ala  Ser Lys Leu Ile Pro  Ile Lys Ser Gly Leu  Ser Pro Glu 
    1130                 1135                 1140             


Lys Tyr  Gly Gly Tyr Ala Arg  Pro Thr Ile Ala Tyr  Ser Val Leu 
    1145                 1150                 1155             


Val Thr  Tyr Lys Gln Asn Asn  Lys Ile Lys Asn Thr  Met Val Gly 
    1160                 1165                 1170             


Ile Pro  Val Leu Thr Lys Leu  Glu Phe Glu Arg Asp  Pro Asn Leu 
    1175                 1180                 1185             


Tyr Leu  Arg Asn Leu Gly Ile  Asn Asn Val Ser His  Val Ile Lys 
    1190                 1195                 1200             


Leu Val  Lys Tyr Thr Val Leu  Glu Phe Lys His Lys  Tyr Gly Thr 
    1205                 1210                 1215             


Tyr Arg  Arg Phe Ile Val Ser  Asn Gln Glu Leu Lys  Arg Ala Asn 
    1220                 1225                 1230             


Gln Ile  Phe Val Thr Thr Lys  Gln Met Lys Leu Ile  Ser Gln Tyr 
    1235                 1240                 1245             


Thr Thr  Leu Asp Lys Asn Glu  His Asp Ser Leu Leu  Lys Asn Asn 
    1250                 1255                 1260             


Gln Gln  Leu Ile Gln Ser Ile  Trp Asn Gln Phe Leu  Glu Phe Met 
    1265                 1270                 1275             


Leu Ala  Thr Asp Leu Val Asn  Lys Lys Gln Tyr Asp  Glu Leu Ile 
    1280                 1285                 1290             


Leu Thr  Asn Asn Gln Thr Ile  Glu Glu Cys Arg Asn  Ile Met Asn 
    1295                 1300                 1305             


Arg Val  Ile Thr Thr Leu Ser  Phe Thr Asn Ile Asn  Ala Gly Gln 
    1310                 1315                 1320             


Lys Lys  Ile Ile Phe Asp Asp  Thr Leu Ser Leu Pro  Ile Lys Arg 
    1325                 1330                 1335             


Trp Gln  Phe Thr Asp Ser Asp  Lys Met Val Lys Lys  Ile Ile Glu 
    1340                 1345                 1350             


Ser Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1355                 1360                 1365             


Ile Asp  Leu Ser Lys Leu Gly  Glu Asp 
    1370                 1375         


<210> 578
<211> 1371
<212> PRT
<213> Streptococcus sp.


<220>
<223> Streptococcus sp. F0441

<400> 578
Met Glu Asn Lys Asn Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ser Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys His Phe Ile Lys Lys Asn Leu 
        35                  40                  45              


Ile Gly Ala Leu Leu Phe Asp Glu Gly Thr Thr Ala Glu Ala Arg Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ser Glu Glu Ile Gly Lys Val Asp Ser 
                85                  90                  95      


Ser Phe Phe His Arg Leu Asp Asp Ser Phe Leu Ile Pro Glu Asp Lys 
            100                 105                 110         


Arg Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Ala Glu Glu Lys Lys 
        115                 120                 125             


Tyr His Lys Gln Phe Pro Thr Ile Tyr His Leu Arg Lys Gln Leu Ala 
    130                 135                 140                 


Asp Ser Lys Glu Lys Thr Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Glu Ala Phe Asp 
                165                 170                 175     


Ile Lys Asn Asn Asp Ile Gln Lys Ile Phe Asn Glu Phe Ile Ser Ile 
            180                 185                 190         


Tyr Asn Asn Thr Phe Glu Gly Asn Ser Leu Ser Gly Gln Asn Val Gln 
        195                 200                 205             


Val Glu Ala Ile Phe Thr Asp Lys Ile Ser Lys Ser Ala Lys Arg Glu 
    210                 215                 220                 


Arg Val Leu Lys Leu Phe Pro Asp Glu Lys Ser Thr Gly Leu Phe Ser 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asp Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Arg Asp Thr Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Asp Phe Ala 
        275                 280                 285             


Asp Leu Phe Leu Val Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asn Pro Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Glu Arg Tyr Glu Asn His Gln Lys Asp Leu Ala Ser Leu 
                325                 330                 335     


Lys Gln Phe Ile Lys Asn Asn Leu Pro Glu Lys Tyr Asp Glu Val Phe 
            340                 345                 350         


Ser Asp Gln Ser Glu Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr 
        355                 360                 365             


Thr Gln Glu Thr Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe 
    370                 375                 380                 


Glu Gly Ala Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met Asn Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Pro 
            420                 425                 430         


Phe Leu Lys Glu Asn Lys Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Arg Asp Phe Ala 
    450                 455                 460                 


Trp Leu Thr Arg Asn Ser Asp Gln Ala Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Ile Val Asp Lys Ala Ser Ser Ala Glu Asp Phe Ile Asn Lys Met 
                485                 490                 495     


Thr Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Phe Ile Ala Glu Gly Leu Arg Asp Tyr Gln Phe Leu Asp Ser Gly 
    530                 535                 540                 


Gln Lys Lys Gln Ile Val Thr Gln Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile Gln Phe Leu His Asn Val Asp Gly Tyr Asp 
                565                 570                 575     


Gly Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Ala Phe Met Asp 
        595                 600                 605             


Asp Ala Lys Asn Glu Ala Ile Leu Glu Asn Ile Val His Thr Leu Thr 
    610                 615                 620                 


Ile Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Gln Tyr Asp 
625                 630                 635                 640 


Ser Leu Phe Asp Glu Lys Val Ile Lys Ala Leu Thr Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Ser Asp 
            660                 665                 670         


Lys Gln Thr Gly Asn Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Glu 
        675                 680                 685             


Ile Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu Ser Phe 
    690                 695                 700                 


Lys Glu Ile Ile Gln Lys Ala Gln Val Val Gly Lys Thr Asn Asp Val 
705                 710                 715                 720 


Lys Gln Val Val Gln Glu Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Ala Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Ala Arg Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg Ile Glu 
    770                 775                 780                 


Asp Ser Leu Lys Ile Leu Ala Ser Gly Leu Asn Ser Lys Ile Leu Lys 
785                 790                 795                 800 


Glu His Pro Thr Asp Asn Ile Gln Leu Gln Asn Asp Arg Leu Phe Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Glu Ala Leu Asp 
            820                 825                 830         


Ile Asn Gln Leu Ser Ser Cys Asp Ile Asp His Ile Ile Pro Gln Ala 
        835                 840                 845             


Phe Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser Ser Lys 
    850                 855                 860                 


Asp Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Leu Glu Val Val Asp 
865                 870                 875                 880 


Lys Met Lys Val Phe Trp Gln Gln Leu Leu Asp Ser Lys Leu Ile Ser 
                885                 890                 895     


Tyr Arg Lys Phe Asn Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Asn 
            900                 905                 910         


Glu Leu Asp Lys Val Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ala Arg Phe Asn Lys 
    930                 935                 940                 


Glu Val Thr Glu Lys Asp Lys Lys Asn Arg Thr Val Lys Ile Ile Thr 
945                 950                 955                 960 


Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr 
                965                 970                 975     


Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Ala Val Val Ala Lys Ala Ile  Leu Lys Lys Tyr Pro  Lys Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Asp  Tyr Gln Lys Tyr Asp  Leu Lys Arg 
    1010                 1015                 1020             


Tyr Ile  Ser Arg Ser Lys Asp  Pro Lys Glu Ile Glu  Lys Ala Thr 
    1025                 1030                 1035             


Glu Lys  Tyr Phe Phe Tyr Ser  Asn Leu Leu Asn Phe  Phe Lys Glu 
    1040                 1045                 1050             


Glu Val  His Tyr Ala Asp Gly  Thr Ile Val Lys Arg  Glu Asn Ile 
    1055                 1060                 1065             


Glu Tyr  Ser Lys Asp Thr Gly  Glu Ile Ala Trp Asn  Lys Glu Lys 
    1070                 1075                 1080             


Asp Phe  Ala Thr Ile Lys Lys  Val Leu Ser Leu Pro  Gln Val Asn 
    1085                 1090                 1095             


Ile Val  Lys Lys Arg Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1100                 1105                 1110             


Ser Ile  Leu Pro Lys Gly Asn  Ser Asp Lys Leu Ile  Pro Arg Lys 
    1115                 1120                 1125             


Thr Lys  Asp Ile Leu Trp Asp  Thr Thr Lys Tyr Gly  Gly Phe Asp 
    1130                 1135                 1140             


Ser Pro  Val Ile Ala Tyr Ser  Ile Leu Leu Ile Ala  Asp Ile Glu 
    1145                 1150                 1155             


Lys Gly  Lys Ala Lys Lys Leu  Lys Thr Val Lys Thr  Leu Val Gly 
    1160                 1165                 1170             


Ile Thr  Ile Met Glu Lys Asp  Ala Phe Glu Lys Asn  Pro Ile Ala 
    1175                 1180                 1185             


Phe Leu  Glu Asn Lys Gly Tyr  His Asn Val Cys Lys  Glu Asn Ile 
    1190                 1195                 1200             


Leu Cys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1205                 1210                 1215             


Arg Arg  Leu Leu Ala Ser Ala  Lys Glu Leu Gln Lys  Cys Asn Glu 
    1220                 1225                 1230             


Ile Val  Leu Pro Val Tyr Leu  Thr Thr Leu Leu Tyr  His Ser Lys 
    1235                 1240                 1245             


Asn Val  His Lys Leu Asp Glu  Pro Gly His Leu Glu  Tyr Ile Gln 
    1250                 1255                 1260             


Lys His  Arg Asn Glu Phe Lys  Asp Leu Leu Asn Leu  Val Ser Glu 
    1265                 1270                 1275             


Phe Ser  Gln Lys Tyr Val Leu  Ala Asp Ala Asn Leu  Glu Lys Ile 
    1280                 1285                 1290             


Lys Asn  Leu Tyr Ala Asp Asn  Glu Gln Ala Asp Ile  Glu Ile Leu 
    1295                 1300                 1305             


Ala Asn  Ser Phe Ile Asn Leu  Leu Thr Phe Thr Ala  Leu Gly Ala 
    1310                 1315                 1320             


Pro Ala  Ala Phe Lys Phe Phe  Gly Lys Asp Val Asp  Arg Lys Arg 
    1325                 1330                 1335             


Tyr Thr  Thr Val Ser Glu Ile  Leu Asn Ala Thr Leu  Ile His Gln 
    1340                 1345                 1350             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Lys Leu 
    1355                 1360                 1365             


Gly Glu  Asp 
    1370     


<210> 579
<211> 1121
<212> PRT
<213> Streptococcus sp.


<220>
<223> Streptococcus sp. GMD6S

<400> 579
Met Asn Gly Leu Val Leu Gly Leu Asp Ile Gly Ile Ala Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Glu Lys Asn Ser Gly Lys Ile Ile His Ala Asn Ser 
            20                  25                  30          


Arg Leu Phe Pro Ala Ala Thr Ala Asp Asn Asn Val Glu Arg Arg Lys 
        35                  40                  45              


Asn Arg Gln Ala Arg Arg Leu His Arg Arg Lys Lys His Arg Gly Val 
    50                  55                  60                  


Arg Phe Gln Asp Leu Phe Glu Asp Tyr Gly Leu Leu Thr Asp Phe Ser 
65                  70                  75                  80  


Lys Val Ser Ile Asn Leu Asn Pro Tyr Arg Leu Arg Val Asp Gly Leu 
                85                  90                  95      


Asn Gln Gln Leu Thr Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Ile 
            100                 105                 110         


Val Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Glu Asp Gly 
        115                 120                 125             


Gly Thr Val Ser Ser Asp Tyr Gly Lys Ala Val Glu Glu Asn Arg Lys 
    130                 135                 140                 


Leu Leu Ala Glu Gln Thr Pro Gly Gln Ile Gln Leu Glu Arg Phe Glu 
145                 150                 155                 160 


Lys Tyr Gly Gln Val Arg Gly Asp Phe Thr Val Val Glu Asn Gly Glu 
                165                 170                 175     


Lys Arg Arg Leu Ile Asn Val Phe Ser Thr Ser Ala Tyr Arg Lys Glu 
            180                 185                 190         


Ala Glu Arg Ile Leu Arg Lys Gln Gln Glu Phe Asn Ser Lys Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Glu Asp Cys Leu Lys Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Phe Arg Thr Asp Gly Thr Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Asp Glu Tyr Arg Ala Ser Lys Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Glu Glu Gln Lys Lys Val Ile 
    290                 295                 300                 


Val Glu Tyr Ala Lys Glu Ala Lys Thr Leu Gly Ala Ser Thr Leu Leu 
305                 310                 315                 320 


Lys Tyr Ile Ala Lys Met Ile Asp Ala Ser Val Asp Gln Ile Arg Gly 
                325                 330                 335     


Tyr Arg Val Asp Val Asn Asn Lys Pro Glu Ile His Thr Phe Glu Ala 
            340                 345                 350         


Tyr Arg Lys Met Gln Ser Leu Glu Thr Ile Ser Val Gly Glu Leu Ser 
        355                 360                 365             


Arg Asn Val Leu Asp Glu Leu Ala His Ile Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Glu Glu Ala Ile Asn Thr Lys Leu Lys Asp Ser Phe 
385                 390                 395                 400 


Ser Gln Asp Gln Val Leu Glu Leu Val Gln Phe Arg Lys Asn Asn Ser 
                405                 410                 415     


Ser Leu Phe Ser Lys Gly Trp His Asn Phe Ser Leu Lys Leu Met Met 
            420                 425                 430         


Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr Ile 
        435                 440                 445             


Leu Thr Arg Leu Gly Lys Gln Lys Ser Lys Glu Ile Ser Lys Arg Thr 
    450                 455                 460                 


Lys Tyr Ile Asp Glu Lys Glu Leu Thr Glu Glu Ile Tyr Asn Pro Val 
465                 470                 475                 480 


Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Ile Asn Glu Ala Thr 
                485                 490                 495     


Lys Lys His Gly Ile Phe Asp Asn Ile Val Ile Glu Met Ala Arg Glu 
            500                 505                 510         


Asn Asn Glu Glu Asp Ala Lys Lys Asp Tyr Ile Lys Arg Gln Lys Ala 
        515                 520                 525             


Asn Gln Asp Glu Lys Asn Ala Ala Met Glu Lys Ala Ala Phe Gln Tyr 
    530                 535                 540                 


Asn Gly Lys Lys Glu Leu Pro Asp Ser Ile Phe His Gly Gln Lys Glu 
545                 550                 555                 560 


Leu Ala Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Lys Cys Leu 
                565                 570                 575     


Tyr Thr Gly Lys Asn Ile Pro Ile Ser Asp Leu Ile His Asn Gln Tyr 
            580                 585                 590         


Lys Tyr Glu Ile Asp His Ile Leu Pro Leu Ser Leu Ser Phe Asp Asp 
        595                 600                 605             


Ser Leu Ser Asn Lys Val Leu Val Leu Ala Thr Ala Asn Gln Glu Lys 
    610                 615                 620                 


Gly Gln Arg Thr Pro Phe Gln Ala Leu Asp Ser Met Asp Asp Ala Trp 
625                 630                 635                 640 


Ser Tyr Arg Glu Phe Lys Ser Tyr Val Lys Glu Ser Lys Leu Leu Gly 
                645                 650                 655     


Asn Lys Lys Lys Glu Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys Ile 
            660                 665                 670         


Glu Val Lys Gln Lys Phe Ile Glu Arg Asn Leu Ile Asp Thr Arg Tyr 
        675                 680                 685             


Ser Ser Arg Val Val Leu Asn Ala Leu Gln Asp Phe Tyr Lys Ala His 
    690                 695                 700                 


Lys Phe Asp Thr Thr Ile Ser Val Val Arg Gly Gln Phe Thr Ser Gln 
705                 710                 715                 720 


Leu Arg Arg Lys Trp Gly Leu Glu Lys Ser Arg Glu Thr Tyr His His 
                725                 730                 735     


His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Arg Leu 
            740                 745                 750         


Trp Lys Lys Gln Asn Asn Pro Leu Ile Ala Tyr Lys Glu Gly Gln Phe 
        755                 760                 765             


Val Asp Ser Glu Thr Gly Glu Ile Ile Ser Leu Ser Asp Asp Glu Tyr 
    770                 775                 780                 


Lys Glu Leu Val Phe Lys Ala Pro Tyr Asp His Phe Val Asp Thr Leu 
785                 790                 795                 800 


Ser Ser Lys Thr Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln Val Asp 
                805                 810                 815     


Ser Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg 
            820                 825                 830         


Lys Ala Lys Leu Asp Lys Glu Lys Ser Glu Glu Thr Tyr Val Leu Gly 
        835                 840                 845             


Lys Ile Lys Asp Ile Tyr Ser Gln Ala Gly Tyr Asp Ala Phe Ile Lys 
    850                 855                 860                 


Ile Tyr Asn Lys Asp Lys Ser Lys Phe Leu Met Tyr His Lys Asp Pro 
865                 870                 875                 880 


Gln Thr Phe Glu Lys Val Ile Glu Glu Ile Leu Arg Thr Tyr Pro Ser 
                885                 890                 895     


Lys Glu Leu Asn Asp Lys Asn Lys Glu Ile Pro Cys Asn Pro Phe Glu 
            900                 905                 910         


Lys Tyr Arg Gln Glu Asn Gly Pro Ile Arg Lys Tyr Ser Lys Lys Ser 
        915                 920                 925             


Asn Gly Pro Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Asn Lys Leu Gly 
    930                 935                 940                 


Asn His Ile Asp Ile Thr Pro Glu Ser Ser Asp Asn Gln Val Val Leu 
945                 950                 955                 960 


Gln Ser Leu Lys Pro Trp Arg Thr Asp Val Tyr Phe Asn His Gln Thr 
                965                 970                 975     


Lys Lys Tyr Glu Leu Met Gly Leu Lys Tyr Ser Asp Leu Ser Phe Glu 
            980                 985                 990         


Lys Gly Ser Gly Lys Tyr Ser Ile  Ser Asn Gln Lys Tyr  Asn Ser Ile 
        995                 1000                 1005             


Lys Arg  Ile Glu Gly Ile Asp  Glu Gln Ser Glu Phe  Lys Phe Thr 
    1010                 1015                 1020             


Leu Tyr  Lys Asn Asp Leu Ile  Leu Ile Lys Asp Ser  Glu Asn Asn 
    1025                 1030                 1035             


Glu Gln  Lys Leu Phe Arg Phe  Asn Ser Arg Asn Asp  Thr Ala Lys 
    1040                 1045                 1050             


His Tyr  Ile Glu Leu Lys Pro  Tyr Asp Lys Ala Lys  Phe Asp Gly 
    1055                 1060                 1065             


Glu Gln  Glu Leu Ile Thr Ile  Leu Gly Asn Val Ala  Lys Gly Gly 
    1070                 1075                 1080             


Arg Cys  Leu Lys Gly Leu Asn  Lys Ser Asn Ile Ser  Ile Phe Lys 
    1085                 1090                 1095             


Val Lys  Thr Asp Val Leu Gly  Lys Lys His Ile Ile  Lys Lys Glu 
    1100                 1105                 1110             


Gly Asp  Glu Pro Lys Leu Lys  Phe 
    1115                 1120     


<210> 580
<211> 1375
<212> PRT
<213> Streptococcus sp.


<220>
<223> Streptococcus sp. M334

<400> 580
Met Ser Asn Lys Ser Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys 
            20                  25                  30          


Met Lys Val Leu Gly Asn Thr Asp Lys His Phe Ile Lys Lys Asn Leu 
        35                  40                  45              


Ile Gly Ala Leu Leu Phe Asp Glu Gly Thr Thr Ala Glu Asp Arg Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ser Gln Glu Ile Ser Lys Val Asp Ser 
                85                  90                  95      


Ser Phe Phe His Arg Leu Asp Asp Phe Phe Leu Val Pro Glu Asp Lys 
            100                 105                 110         


Arg Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Val Glu Glu Lys Glu 
        115                 120                 125             


Tyr His Lys Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala 
    130                 135                 140                 


Asp Ser Lys Glu Lys Thr Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Glu Ser Phe Asp 
                165                 170                 175     


Ile Lys Asn Asn Asp Ile Gln Lys Ile Phe Ser Glu Phe Ile Ser Ile 
            180                 185                 190         


Tyr Asp Asn Thr Phe Glu Gly Lys Ser Leu Ser Gly Gln Asn Ala Gln 
        195                 200                 205             


Val Glu Ala Ile Phe Thr Asp Lys Ile Ser Lys Ser Thr Lys Arg Glu 
    210                 215                 220                 


Arg Val Leu Lys Leu Phe Pro Asp Glu Lys Ser Thr Gly Leu Phe Ser 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asp Leu Glu Glu Lys Ala Pro Leu Gln Phe Ser Lys Asp Thr Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Asp Phe Ala 
        275                 280                 285             


Asp Leu Phe Leu Val Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Lys Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Glu Arg Tyr Glu Asn His Gln Lys Asp Leu Ala Ala Leu 
                325                 330                 335     


Lys Gln Phe Ile Gln Asn Asn Leu Gln Glu Lys Tyr Asp Glu Val Phe 
            340                 345                 350         


Ser Asp Gln Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr 
        355                 360                 365             


Thr Gln Glu Ala Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe 
    370                 375                 380                 


Glu Gly Ala Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Lys Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met Asn Ala Ile Ile Arg Arg Gln Gly Glu His Tyr Pro 
            420                 425                 430         


Phe Leu Gln Glu Asn Lys Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Gly Asp Phe Ala 
    450                 455                 460                 


Trp Leu Thr Arg Asn Ser Asp Gln Ala Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Ile Val Asp Gln Ala Ser Ser Ala Glu Asp Phe Ile Asn Lys Met 
                485                 490                 495     


Thr Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Phe Ile Ala Glu Gly Leu Thr Arg Tyr Gln Phe Leu Asp Lys Lys 
    530                 535                 540                 


Gln Lys Lys Asp Ile Phe Asp Thr Phe Phe Lys Ala Glu Asn Lys Arg 
545                 550                 555                 560 


Lys Val Thr Glu Lys Asp Ile Ile His Tyr Leu His Asn Val Asp Gly 
                565                 570                 575     


Tyr Asp Gly Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser 
            580                 585                 590         


Leu Ser Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Ala Phe 
        595                 600                 605             


Met Asp Asp Ser Lys Asn Glu Glu Ile Leu Glu Asn Ile Ile His Thr 
    610                 615                 620                 


Leu Thr Ile Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Gln 
625                 630                 635                 640 


Tyr Asp Ser Leu Phe Asp Glu Lys Val Ile Lys Ala Leu Thr Arg Arg 
                645                 650                 655     


His Tyr Thr Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile 
            660                 665                 670         


Arg Asp Lys Lys Ser Gly Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 
        675                 680                 685             


Gly Glu Ile Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Gly Leu 
    690                 695                 700                 


Ser Phe Lys Glu Ile Ile Gln Lys Ala Gln Val Phe Gly Lys Thr Asn 
705                 710                 715                 720 


Asp Val Lys Gln Val Val Gln Glu Leu Pro Gly Ser Pro Ala Ile Lys 
                725                 730                 735     


Lys Gly Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val 
            740                 745                 750         


Met Gly His Ala Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Thr Thr Ala Arg Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg 
    770                 775                 780                 


Ile Glu Asp Ser Leu Lys Asn Leu Ala Ser Gly Leu Asp Ser Asn Ile 
785                 790                 795                 800 


Leu Lys Glu Asn Pro Thr Asp Asn Ile Gln Leu Gln Asn Asp Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Thr Gly Lys Pro 
            820                 825                 830         


Leu Glu Ile Asn Gln Leu Ser Asn Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser 
    850                 855                 860                 


Ser Lys Asp Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Leu Glu Val 
865                 870                 875                 880 


Val Glu Lys Met Lys Ala Phe Trp Gln Gln Leu Leu Asp Ser Lys Leu 
                885                 890                 895     


Ile Ser Glu Arg Lys Phe Asn Asn Leu Thr Lys Ala Glu Arg Glu Arg 
            900                 905                 910         


Gly Gly Leu Asn Glu Leu Asp Lys Val Gly Phe Ile Lys Arg Gln Leu 
        915                 920                 925             


Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Phe Leu Asp Ala 
    930                 935                 940                 


Arg Phe Asn Lys Glu Val Thr Glu Lys Asp Lys Lys Asn Arg Asn Val 
945                 950                 955                 960 


Lys Ile Ile Thr Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu 
                965                 970                 975     


Phe Gly Leu Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His 
            980                 985                 990         


Asp Ala Tyr Leu Asn Ala Val Leu  Ala Lys Ala Ile Leu  Lys Lys Tyr 
        995                 1000                 1005             


Pro Lys  Leu Glu Pro Glu Phe  Val Tyr Gly Asp Tyr  Gln Lys Tyr 
    1010                 1015                 1020             


Asp Leu  Gln Arg Tyr Ile Ser  Lys Ser Arg Glu Pro  Lys Glu Val 
    1025                 1030                 1035             


Glu Lys  Ala Thr Gln Lys Tyr  Phe Phe Tyr Ser Asn  Leu Leu Asn 
    1040                 1045                 1050             


Phe Phe  Lys Glu Glu Val His  Tyr Ala Asp Gly Thr  Ile Val Lys 
    1055                 1060                 1065             


Arg Glu  Asn Ile Glu Tyr Ser  Lys Asp Thr Gly Glu  Ile Ala Trp 
    1070                 1075                 1080             


Asn Lys  Glu Lys Asp Phe Ala  Thr Val Lys Lys Val  Leu Ser Leu 
    1085                 1090                 1095             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly 
    1100                 1105                 1110             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Gly Asn Ser  Asp Lys Leu 
    1115                 1120                 1125             


Ile Pro  Arg Lys Thr Lys Glu  Ile Leu Trp Asp Thr  Thr Lys Tyr 
    1130                 1135                 1140             


Gly Gly  Phe Asp Ser Pro Val  Ile Ala Tyr Ser Ile  Leu Leu Ile 
    1145                 1150                 1155             


Ala Asp  Ile Glu Lys Gly Lys  Ala Lys Lys Leu Lys  Thr Val Lys 
    1160                 1165                 1170             


Thr Leu  Val Gly Ile Thr Ile  Met Glu Lys Ala Thr  Phe Glu Lys 
    1175                 1180                 1185             


Asn Pro  Ile Thr Phe Leu Glu  Asn Lys Gly Tyr His  Asn Val Arg 
    1190                 1195                 1200             


Lys Glu  Asn Ile Leu Cys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu 
    1205                 1210                 1215             


Glu Ser  Gly Arg Arg Arg Met  Leu Ala Ser Ala Lys  Glu Leu Gln 
    1220                 1225                 1230             


Lys Gly  Asn Glu Ile Val Leu  Pro Val Tyr Leu Thr  Thr Leu Leu 
    1235                 1240                 1245             


Tyr His  Ser Lys Asn Val His  Lys Leu Asp Glu Pro  Glu His Leu 
    1250                 1255                 1260             


Glu Tyr  Ile Gln Lys His Arg  Tyr Glu Phe Lys Asp  Leu Leu Asn 
    1265                 1270                 1275             


Leu Val  Ser Glu Phe Ser Gln  Lys Tyr Val Leu Ala  Asp Ala Asn 
    1280                 1285                 1290             


Leu Glu  Lys Ile Lys Asn Leu  Tyr Ala Asp Asn Glu  Gln Ala Asp 
    1295                 1300                 1305             


Ile Glu  Ile Leu Ala Asn Ser  Phe Ile Asn Leu Leu  Thr Phe Thr 
    1310                 1315                 1320             


Ala Leu  Gly Ala Pro Ala Ala  Phe Lys Phe Leu Gly  Lys Asp Val 
    1325                 1330                 1335             


Asp Arg  Lys Arg Tyr Thr Thr  Val Ser Glu Ile Leu  Asn Ala Thr 
    1340                 1345                 1350             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1355                 1360                 1365             


Leu Ser  Lys Leu Gly Glu Asp  
    1370                 1375 


<210> 581
<211> 1371
<212> PRT
<213> Streptococcus sp.


<220>
<223> Streptococcus sp. oral taxon 056 str. F0418

<400> 581
Met Asn Asn Asn Asn Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys 
            20                  25                  30          


Met Arg Val Leu Gly Asn Thr Asp Lys Arg Phe Ile Lys Lys Asn Leu 
        35                  40                  45              


Ile Gly Ala Leu Leu Phe Asp Glu Gly Thr Thr Ala Glu Asp Arg Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Ser 
                85                  90                  95      


Ser Phe Phe His Arg Leu Asp Asp Ser Phe Leu Val Pro Glu Asp Lys 
            100                 105                 110         


Ser Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Ala Glu Glu Lys Glu 
        115                 120                 125             


Tyr His Lys Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala 
    130                 135                 140                 


Asp Ser Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Ile Thr Lys Tyr Arg Gly His Phe Leu Tyr Glu Glu Ala Phe Asp 
                165                 170                 175     


Ile Lys Asn Asn Asp Ile Gln Lys Ile Phe Asn Glu Phe Ile Asn Ile 
            180                 185                 190         


Tyr Asp Asn Thr Phe Glu Gly Ser Ser Leu Ser Gly Gln Asn Ala Gln 
        195                 200                 205             


Val Glu Ala Ile Phe Thr Gly Lys Ile Ser Lys Ser Val Lys Arg Glu 
    210                 215                 220                 


His Val Leu Lys Leu Phe Pro Asp Glu Lys Ser Thr Gly Leu Phe Ser 
225                 230                 235                 240 


Glu Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Lys Lys His 
                245                 250                 255     


Phe Asp Leu Glu Glu Lys Ala Ser Leu Gln Phe Ser Lys Asp Thr Tyr 
            260                 265                 270         


Asp Glu Asp Leu Glu Asn Leu Leu Gly Gln Ile Gly Asp Asp Phe Ala 
        275                 280                 285             


Asp Leu Phe Leu Val Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser 
    290                 295                 300                 


Gly Ile Leu Thr Val Thr Asp Pro Ser Thr Lys Ala Pro Leu Ser Ala 
305                 310                 315                 320 


Ser Met Ile Glu Arg Tyr Glu Asn His Gln Glu Asp Leu Ala Ala Leu 
                325                 330                 335     


Lys Gln Phe Ile Lys Asn Asn Leu Pro Glu Lys Tyr Ala Glu Val Phe 
            340                 345                 350         


Ser Asp Gln Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr 
        355                 360                 365             


Thr Gln Glu Ala Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe 
    370                 375                 380                 


Glu Gly Ala Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met Asn Ala Ile Leu Arg Arg Gln Gly Glu His Tyr Pro 
            420                 425                 430         


Leu Leu Lys Glu Asn Lys Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Arg Asp Phe Ala 
    450                 455                 460                 


Trp Leu Thr Arg Asn Ser Asp Gln Ala Ile Arg Pro Trp Asn Phe Glu 
465                 470                 475                 480 


Glu Ile Val Asp Lys Ala Ser Ser Ala Glu Ser Phe Ile Asn Lys Met 
                485                 490                 495     


Thr Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Phe Ile Ala Glu Gly Leu Arg Asp Tyr Gln Phe Phe Asp Ser Gly 
    530                 535                 540                 


Gln Lys Lys Gln Ile Val Asn Gln Leu Phe Lys Glu Lys Arg Lys Val 
545                 550                 555                 560 


Thr Glu Lys Asp Ile Ile His Tyr Leu His Asn Val Asp Gly Tyr Asp 
                565                 570                 575     


Gly Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ala Ser Leu Ser 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Glu Phe Met Asp 
        595                 600                 605             


Asn His Lys Asn Gln Glu Ile Leu Glu Asn Ile Val His Thr Leu Thr 
    610                 615                 620                 


Ile Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ala Gln Tyr Asp 
625                 630                 635                 640 


Ser Ile Phe Asp Glu Lys Val Ile Lys Ala Leu Thr Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Cys Asp 
            660                 665                 670         


Lys Lys Thr Gly Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Tyr 
        675                 680                 685             


Asn Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Gly Leu Ser Phe 
    690                 695                 700                 


Lys Glu Ile Ile Gln Lys Ala Gln Val Val Gly Lys Thr Asp Asp Leu 
705                 710                 715                 720 


Thr Gln Val Val Arg Glu Leu Ser Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Ile Met Gly 
            740                 745                 750         


Tyr Ala Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Ala Lys Gly Lys Lys Asn Ser Gln Gln Arg Tyr Lys Arg Ile Glu 
    770                 775                 780                 


Asp Ala Leu Lys Asn Leu Ala Pro Gly Leu Asp Ser Thr Ile Ser Lys 
785                 790                 795                 800 


Glu Asn Pro Thr Asp Asn Ile Gln Leu Gln Asn Asp Arg Leu Phe Leu 
                805                 810                 815     


Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly Glu Ala Leu Asp 
            820                 825                 830         


Ile Asn Gln Leu Ser Ser Tyr Asp Ile Asp His Ile Ile Pro Gln Ala 
        835                 840                 845             


Phe Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser Ser Lys 
    850                 855                 860                 


Asp Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Leu Glu Val Val Lys 
865                 870                 875                 880 


Lys Arg Lys Ala Phe Trp Gln Gln Leu Leu Asp Ser Lys Leu Ile Ser 
                885                 890                 895     


Glu Arg Lys Phe Asn Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Asp 
            900                 905                 910         


Glu Arg Asp Lys Val Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg 
        915                 920                 925             


Gln Ile Thr Lys His Val Ala Arg Ile Leu Asp Ala Arg Phe Asn Thr 
    930                 935                 940                 


Glu Val Ser Glu Lys Asn Gln Lys Ile Arg Ser Val Lys Ile Ile Thr 
945                 950                 955                 960 


Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Lys Leu Tyr 
                965                 970                 975     


Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 
            980                 985                 990         


Asn Ala Val Val Ala Lys Ala Ile  Leu Lys Lys Tyr Pro  Lys Leu Glu 
        995                 1000                 1005             


Pro Glu  Phe Val Tyr Gly Asp  Tyr Gln Lys Tyr Asp  Leu Lys Arg 
    1010                 1015                 1020             


Tyr Ile  Ser Lys Ser Lys Asp  Pro Lys Glu Val Glu  Lys Ala Thr 
    1025                 1030                 1035             


Glu Lys  Tyr Phe Phe Tyr Ser  Asn Leu Leu Asn Phe  Phe Lys Glu 
    1040                 1045                 1050             


Glu Val  His Tyr Ala Asp Gly  Thr Ile Val Lys Arg  Glu Asn Ile 
    1055                 1060                 1065             


Glu Tyr  Ser Lys Asp Thr Gly  Glu Ile Ala Trp Asn  Lys Glu Lys 
    1070                 1075                 1080             


Asp Phe  Val Thr Ile Lys Lys  Val Leu Ser Tyr Pro  Gln Val Asn 
    1085                 1090                 1095             


Ile Val  Lys Lys Arg Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1100                 1105                 1110             


Ser Ile  Leu Pro Lys Gly Asn  Ser Asp Lys Leu Ile  Pro Arg Lys 
    1115                 1120                 1125             


Thr Lys  Asp Ile Leu Trp Asp  Thr Thr Lys Tyr Gly  Gly Phe Asp 
    1130                 1135                 1140             


Ser Pro  Val Ile Ala Tyr Ser  Ile Leu Leu Ile Ala  Asp Ile Glu 
    1145                 1150                 1155             


Lys Gly  Lys Ala Lys Lys Leu  Lys Thr Val Lys Thr  Leu Val Gly 
    1160                 1165                 1170             


Ile Thr  Ile Met Glu Lys Ala  Ala Phe Glu Lys Asn  Pro Ile Thr 
    1175                 1180                 1185             


Phe Leu  Glu Asn Lys Gly Tyr  His Asn Val Arg Lys  Glu Asn Ile 
    1190                 1195                 1200             


Leu Cys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1205                 1210                 1215             


Arg Arg  Leu Leu Ala Ser Ala  Lys Glu Leu Gln Lys  Gly Asn Glu 
    1220                 1225                 1230             


Ile Val  Leu Pro Val Tyr Leu  Thr Thr Leu Leu Tyr  His Ser Lys 
    1235                 1240                 1245             


Asn Val  His Lys Leu Asp Glu  Pro Glu His Leu Glu  Tyr Ile Gln 
    1250                 1255                 1260             


Lys His  Arg Tyr Glu Phe Lys  Asp Leu Leu Asn Leu  Val Ser Glu 
    1265                 1270                 1275             


Phe Ser  Gln Lys Tyr Val Leu  Ala Glu Ala Asn Leu  Glu Lys Ile 
    1280                 1285                 1290             


Lys Ser  Leu Tyr Val Asp Asn  Glu Gln Ala Asp Ile  Glu Ile Leu 
    1295                 1300                 1305             


Ala Asn  Ser Phe Ile Asn Leu  Leu Thr Phe Thr Ala  Leu Gly Ala 
    1310                 1315                 1320             


Pro Ala  Ala Phe Lys Phe Phe  Gly Lys Asp Val Asp  Arg Lys Arg 
    1325                 1330                 1335             


Tyr Thr  Thr Val Ser Glu Ile  Leu Asn Ala Thr Leu  Ile His Gln 
    1340                 1345                 1350             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Lys Leu 
    1355                 1360                 1365             


Gly Glu  Asp 
    1370     


<210> 582
<211> 1420
<212> PRT
<213> Streptococcus sp.


<220>
<223> Streptococcus sp. oral taxon 071 str. 73H25AP

<400> 582
Met Ala Lys Phe Asn Lys Asn Tyr Ser Ile Gly Leu Asp Ile Gly Val 
1               5                   10                  15      


Ser Ser Val Gly Tyr Ala Val Val Thr Glu Asp Tyr Arg Val Pro Ala 
            20                  25                  30          


Phe Lys Phe Lys Val Leu Gly Asn Thr Glu Lys Glu Lys Ile Lys Lys 
        35                  40                  45              


Asn Leu Ile Gly Ser Thr Thr Phe Val Pro Ala Gln Ser Ala Gln Gly 
    50                  55                  60                  


Thr Arg Val Phe Arg Val Asn Arg Arg Arg Ile Asp Arg Arg Asn His 
65                  70                  75                  80  


Arg Ile Ala Tyr Leu Arg Asp Ile Phe Gln Lys Glu Ile Glu Lys Ile 
                85                  90                  95      


Asp Lys Asn Phe Tyr Arg Arg Leu Asp Glu Ser Phe Arg Val Leu Gly 
            100                 105                 110         


Asp Lys Ser Glu Asp Ile Gln Ile Lys Gln Pro Phe Phe Gly Asn Lys 
        115                 120                 125             


Glu Leu Glu Thr Ala Tyr His Lys Lys Tyr Pro Thr Ile Tyr His Leu 
    130                 135                 140                 


Arg Lys His Leu Ala Asp Ala Asp Lys Asn Ser Pro Val Ala Asp Ile 
145                 150                 155                 160 


Arg Glu Val Tyr Met Val Leu Ser His Ile Leu Lys Tyr Arg Gly His 
                165                 170                 175     


Phe Leu Thr Leu Gly Lys Ile Asp Pro Asn Asn Ile Asn Met Gln Asn 
            180                 185                 190         


Ser Trp Ile Asp Phe Ile Glu Ser Cys Gln Asp Ala Phe Asp Leu Glu 
        195                 200                 205             


Ile Ser Asp Glu Ser Lys Thr Ile Ala Ala Ile Phe Lys Ser Ser Glu 
    210                 215                 220                 


Asn Arg Gln Glu Lys Val Lys Gln Ile Leu Ser Tyr Phe Gln Gln Glu 
225                 230                 235                 240 


Leu Leu Lys Lys Asp Lys Ser Ile Phe Lys Gln Leu Leu Gln Leu Leu 
                245                 250                 255     


Phe Gly Leu Lys Thr Lys Phe Lys Asp Cys Phe Glu Leu Glu Glu Glu 
            260                 265                 270         


Pro Asp Leu Asn Phe Ser Lys Glu Asn Tyr Asp Glu Asn Leu Glu Asn 
        275                 280                 285             


Leu Leu Gly Ala Leu Glu Glu Asp Phe Ser Asp Val Phe Ala Lys Leu 
    290                 295                 300                 


Lys Ile Leu Arg Asp Thr Ile Leu Leu Ser Ser Met Leu Thr Tyr Thr 
305                 310                 315                 320 


Gly Ala Thr His Ala Arg Phe Ser Ala Thr Met Val Glu Arg Tyr Glu 
                325                 330                 335     


Glu His Arg Lys Asp Leu Gln Arg Phe Lys Ser Phe Val Lys Gln Asn 
            340                 345                 350         


Leu Ser Glu Gln Asp Tyr Leu Asp Ile Phe Gly Arg Lys Thr Pro Thr 
        355                 360                 365             


Gly Phe Asp Val Asp Lys Glu Thr Lys Gly Tyr Val Gly Tyr Ile Ser 
    370                 375                 380                 


Asn Lys Met Val Leu Thr Asn Pro Gln Lys Gln Lys Thr Ile Gln Gln 
385                 390                 395                 400 


Asn Phe Tyr Asp Tyr Ile Ser Gly Lys Ile Thr Gly Ile Glu Gly Ala 
                405                 410                 415     


Glu Cys Phe Leu Asn Lys Ile Ser Asp Gly Thr Phe Leu Arg Lys Leu 
            420                 425                 430         


Arg Thr Thr Asp Asn Gly Ala Ile Pro Asn Gln Ile His Ala Tyr Glu 
        435                 440                 445             


Leu Glu Lys Ile Ile Glu Arg Gln Gly Arg Asp Tyr Pro Phe Leu Leu 
    450                 455                 460                 


Glu Asn Lys Asp Lys Leu Leu Ser Ile Leu Thr Phe Lys Ile Pro Tyr 
465                 470                 475                 480 


Tyr Val Gly Pro Leu Ala Lys Gly Asn Asn Ser Arg Phe Ala Trp Ile 
                485                 490                 495     


Lys Arg Thr Thr Ser Gln Asp Val Leu Asp Asp Asn Asp Glu Asp Thr 
            500                 505                 510         


Arg Asn Gly Lys Ile Arg Pro Trp Asn Tyr His Lys Leu Ile Asn Met 
        515                 520                 525             


Asp Glu Thr Arg Asp Ala Phe Ile Ile Asn Leu Ile Gly Asn Asp Ile 
    530                 535                 540                 


Ile Leu Leu Asn Glu Lys Val Leu Pro Lys Arg Ser Leu Ile Tyr Glu 
545                 550                 555                 560 


Glu Val Met Leu Gln Asn Glu Leu Thr Arg Val Lys Tyr Lys Asp Lys 
                565                 570                 575     


Tyr Gly Lys Ile His Phe Phe Asn Ser Glu Leu Arg Gln Glu Ile Ile 
            580                 585                 590         


Asn Asn Leu Phe Lys Thr Asn Ser Lys Arg Val Ser Ser Ala Met Leu 
        595                 600                 605             


Leu Ser Tyr Leu Glu Asn Phe Thr Asn Leu Gln Ala Val Glu Ile Val 
    610                 615                 620                 


Ser Gly Ile Glu Lys Gly Lys Ser Leu Asn Ser Thr Leu Lys Thr Tyr 
625                 630                 635                 640 


Asn Asp Leu Lys Thr Ile Phe Ser Glu Glu Leu Leu Asp Ser Glu Ile 
                645                 650                 655     


Tyr Gln Lys Glu Leu Glu Glu Ile Ile Lys Val Ile Thr Val Phe Asp 
            660                 665                 670         


Asp Lys Lys Ser Ile Lys Asn Tyr Leu Thr Lys Tyr Phe Gly His Leu 
        675                 680                 685             


Glu Phe Leu Asn Glu Glu Lys Ile Asn Gln Leu Ser Lys Leu Arg Tyr 
    690                 695                 700                 


Thr Gly Trp Gly Arg Tyr Ser Gly Lys Leu Leu Leu Gly Ile Arg Asp 
705                 710                 715                 720 


Glu Asp Thr Gly Phe Asn Leu Met Gln Phe Leu Arg Asn Asp Asp Glu 
                725                 730                 735     


Asn Arg Asn Leu Thr Gln Leu Ile Ser Asp Thr Thr Leu Ser Phe Asp 
            740                 745                 750         


Ser Ala Ile Lys Ala Ile Gln Ser Lys Ser Thr Val Glu Asp Asp Val 
        755                 760                 765             


Phe Glu Glu Ile Lys Asn Leu Ala Gly Ser Pro Ala Ile Lys Arg Gly 
    770                 775                 780                 


Ile Leu Asn Ser Ile Lys Ile Val Asp Glu Leu Val Gln Ile Ile Gly 
785                 790                 795                 800 


Tyr Pro Pro Gln Asn Ile Ile Ile Glu Met Ala Arg Glu Asn Met Thr 
                805                 810                 815     


Thr Glu Glu Gly Gln Lys Lys Ala Lys Thr Arg Lys Ser Lys Leu Glu 
            820                 825                 830         


Ser Ala Leu Lys Asn Ile Glu Asp Ser Val Leu Glu Ser Gly Lys Val 
        835                 840                 845             


Pro His Ser Asp Glu Gln Leu Gln Ser Glu Lys Leu Tyr Leu Tyr Tyr 
    850                 855                 860                 


Leu Gln Asn Gly Lys Asp Met Tyr Ser Leu Asp Lys Thr Gly Ser Pro 
865                 870                 875                 880 


Thr Pro Leu Tyr Arg Asp Gln Leu Asp Gln Tyr Glu Val Asp His Ile 
                885                 890                 895     


Ile Pro Tyr Ser Phe Leu Pro Ile Asp Ser Ile Asp Asn Lys Val Leu 
            900                 905                 910         


Thr His Arg Glu Asn Asn Gln Arg Lys Leu Asn Asn Ile Pro Asp Lys 
        915                 920                 925             


Glu Thr Val Ala Asn Met Lys Pro Phe Trp Glu Lys Leu Tyr Asn Ala 
    930                 935                 940                 


Lys Leu Ile Ser Gln Thr Lys Tyr Gln Arg Leu Thr Thr Ser Glu Arg 
945                 950                 955                 960 


Thr Pro Asp Gly Val Leu Thr Glu Ser Met Lys Ala Gly Phe Ile Glu 
                965                 970                 975     


Arg Gln Leu Val Glu Thr Arg Gln Ile Ile Lys His Val Ala Arg Ile 
            980                 985                 990         


Leu Asp Asn Arg Phe Ser Asp Thr  Lys Ile Ile Thr Leu  Lys Ser Gln 
        995                 1000                 1005             


Leu Val  Thr Asn Phe Arg Asn  Thr Phe His Ile Ala  Lys Ile Arg 
    1010                 1015                 1020             


Glu Leu  Asn Asp Tyr His His  Ala His Asp Ala Tyr  Leu Ala Val 
    1025                 1030                 1035             


Val Val  Gly Gln Thr Leu Leu  Lys Ala Tyr Pro Lys  Leu Ala Pro 
    1040                 1045                 1050             


Glu Leu  Ile Tyr Gly His His  Ala His Phe Asn Arg  His Glu Glu 
    1055                 1060                 1065             


Asn Lys  Ala Thr Leu Arg Lys  His Leu Tyr Ser Asn  Ile Met Arg 
    1070                 1075                 1080             


Phe Phe  Asn Asn Pro Asp Ser  Lys Val Ser Lys Asp  Ile Trp Asp 
    1085                 1090                 1095             


Cys Asn  Arg Asp Leu Pro Ile  Val Lys Asp Val Ile  Tyr Asn Ser 
    1100                 1105                 1110             


Gln Ile  Asn Phe Val Lys Arg  Thr Met Ile Lys Lys  Gly Ala Phe 
    1115                 1120                 1125             


Tyr Asn  Gln Asn Pro Val Gly  Lys Leu Asn Lys Gln  Ile Ala Ala 
    1130                 1135                 1140             


Asn Asn  Arg Tyr Pro Leu Lys  Thr Lys Val Ser Ser  Leu Asp Thr 
    1145                 1150                 1155             


Ser Ile  Tyr Gly Gly Tyr Gly  Pro Met Asn Ser Ala  Leu Ser Ile 
    1160                 1165                 1170             


Ile Ile  Ile Ala Glu Arg Phe  Asn Glu Lys Lys Gly  Lys Ile Glu 
    1175                 1180                 1185             


Thr Val  Lys Glu Phe His Asp  Ile Phe Ile Ile Asp  Tyr Glu Lys 
    1190                 1195                 1200             


Phe Asn  Asn Asn Pro Phe Gln  Phe Leu Asn Asn Val  Ser Glu Glu 
    1205                 1210                 1215             


Gly Phe  Leu Lys Lys Asn Asp  Leu Asn Arg Val Leu  Ala Phe Tyr 
    1220                 1225                 1230             


Arg Ile  Ser Lys Tyr Ser Leu  Met Gln Lys Ile Asp  Gly Thr Arg 
    1235                 1240                 1245             


Met Leu  Phe Glu Ser Lys Ser  Asn Leu His Lys Val  Thr Gln Phe 
    1250                 1255                 1260             


Lys Leu  Thr Lys Thr Gln Asn  Glu Leu Phe Phe His  Met Lys Arg 
    1265                 1270                 1275             


Leu Leu  Thr Lys Ser Asn Leu  Met Asp Leu Lys Ser  Glu Ser Ala 
    1280                 1285                 1290             


Ile Lys  Glu Ser Gln Asn Phe  Ile Gln Thr His Gln  Asn Glu Phe 
    1295                 1300                 1305             


Asp Asn  Ile Ala Asp Arg Leu  Ser Asn Tyr Ser Gln  Lys Met Leu 
    1310                 1315                 1320             


Gly Glu  Thr Lys Ser Leu Gln  Thr Leu Ile Asn Gly  Tyr Asn Glu 
    1325                 1330                 1335             


Arg Pro  Ile Lys Gln Ile Asp  Asn Asn Glu Glu Thr  Ile Arg Tyr 
    1340                 1345                 1350             


Tyr Tyr  Asp Asn Phe Ile Lys  Met Phe Ser Phe Val  Lys Ser Gly 
    1355                 1360                 1365             


Ala Pro  Lys Asp Ile Ile Asn  Phe Phe Asn Asp Lys  Tyr Thr Val 
    1370                 1375                 1380             


Pro Arg  Met Arg Pro Lys Pro  Asp Arg Lys Met Leu  Asp Ala Thr 
    1385                 1390                 1395             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1400                 1405                 1410             


Leu Ser  Lys Leu Gly Glu Asp  
    1415                 1420 


<210> 583
<211> 1122
<212> PRT
<213> Streptococcus suis


<220>
<223> Streptococcus suis 89/1591

<400> 583
Met Ser Asn Gly Lys Ile Leu Gly Leu Asp Ile Gly Ile Ala Ser Val 
1               5                   10                  15      


Gly Val Gly Val Ile Asp Ala Gln Thr Gly Glu Ile Ile His Ala Ser 
            20                  25                  30          


Ser Arg Ile Phe Pro Ser Ala Asn Ala Ala Asn Asn Ala Glu Arg Arg 
        35                  40                  45              


Thr Phe Arg Gly Ser Arg Arg Leu Ile Arg Arg Lys Lys His Arg Ile 
    50                  55                  60                  


Lys Arg Leu Asp Asp Leu Phe Asn Asp Phe His Ile Asn Leu Asp Gly 
65                  70                  75                  80  


Glu Met Ser Thr Asp Asn Pro Tyr Val Leu Arg Val Lys Gly Leu Ser 
                85                  90                  95      


Gln Lys Leu Thr Val Glu Glu Leu Tyr Ile Ser Ile Lys Asn Ile Met 
            100                 105                 110         


Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Glu Ser Asp Asn Glu 
        115                 120                 125             


Ala Gly Arg Ser Asp Tyr Ala Lys Ala Ile Glu Arg Asn Arg Gln Leu 
    130                 135                 140                 


Leu Thr Ser Lys Thr Pro Gly Glu Ile Gln Leu Glu Arg Leu Glu Lys 
145                 150                 155                 160 


Tyr Gly Gln Leu Arg Gly Asn Phe Thr Ile Ile Asp Glu Glu Gly Gln 
                165                 170                 175     


Ser Gln Gln Ile Ile Asn Val Phe Ser Thr Ser Asp Tyr Val Lys Glu 
            180                 185                 190         


Val Glu Lys Ile Leu Asp Cys Gln Lys Met Tyr His Lys Phe Ile Ser 
        195                 200                 205             


Asp Glu Phe Cys Asp Lys Leu Ile Glu Leu Leu Arg Glu Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr Val Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Ile 
225                 230                 235                 240 


Tyr Arg Thr Asp Gly Thr Thr Leu Glu Asn Leu Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Asp Gln Tyr Arg Ser Ser Arg Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Phe Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Gln Glu Gln Lys Glu Phe Leu 
    290                 295                 300                 


Val Asn Tyr Ala Lys Glu Thr Ser Val Leu Gly Ala Gly Lys Ile Leu 
305                 310                 315                 320 


Gln Gln Ile Ala Lys Leu Ala Asp Cys Lys Val Glu Asp Ile Arg Gly 
                325                 330                 335     


Tyr Arg Leu Asp Asn Lys Asp Lys Pro Glu Leu His Thr Phe Glu Thr 
            340                 345                 350         


Tyr Arg Ala Met Lys Gly Leu Val Pro Leu Val Asp Ile Gly Val Leu 
        355                 360                 365             


Ser Arg Glu Gln Leu Asp Ile Leu Ala Asp Ile Leu Thr Leu Asn Thr 
    370                 375                 380                 


Asp Phe Glu Gly Ile Arg Glu Ala Leu Lys Lys Gln Leu Pro Asn Val 
385                 390                 395                 400 


Phe Asp Glu Lys Gln Val Lys Gly Leu Ala Ser Phe Arg Lys Ser Lys 
                405                 410                 415     


Ser Gln Leu Phe Ala Lys Gly Trp His Asn Leu Ser Gln Lys Ile Met 
            420                 425                 430         


Leu Glu Val Ile Pro Glu Leu Tyr Ala Thr Ser Asp Glu Gln Met Thr 
        435                 440                 445             


Ile Leu Thr Arg Leu Gly Lys Phe Glu Lys Ser Ser Val Ala Glu Tyr 
    450                 455                 460                 


Pro Ser Ser Ile Asn Val Asp Glu Ile Thr Asp Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ala Lys Ser Ile Arg Gln Thr Ile Lys Ile Ile Asn Ala Ser 
                485                 490                 495     


Ile Lys Lys Trp Gly Glu Phe Asp Gln Ile Val Ile Glu Met Pro Arg 
            500                 505                 510         


Asp Arg Asn Glu Asp Glu Glu Lys Lys Arg Ile Ala Asp Gly Gln Lys 
        515                 520                 525             


Ala Asn Ala Lys Glu Lys Ala Asp Ser Ile Leu Arg Ala Ala Glu Leu 
    530                 535                 540                 


Tyr Cys Ala Gly Lys Val Leu Pro Asp Tyr Val Tyr Asn Gly His Asn 
545                 550                 555                 560 


Gln Leu Ala Thr Lys Ile Arg Leu Trp Tyr Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Ile Tyr Thr Gly Gln Pro Ile Ser Ile His Asp Leu Ile His Asn Gln 
            580                 585                 590         


Asn Gln Tyr Glu Ile Asp His Ile Leu Pro Leu Ser Leu Thr Phe Asp 
        595                 600                 605             


Asp Ser Leu Ser Asn Lys Val Leu Val Leu Ala Thr Ala Asn Gln Glu 
    610                 615                 620                 


Lys Ala Gln Arg Thr Pro Tyr Asn Tyr Leu Lys Ser Ala Thr Ser Ala 
625                 630                 635                 640 


Trp Ser Tyr Arg Glu Phe Lys Asp Tyr Val Thr Lys Arg Lys Gly Ile 
                645                 650                 655     


Gly Lys Lys Lys Cys Glu Tyr Leu Thr Phe Glu Glu Asp Ile Asn Gly 
            660                 665                 670         


Phe Glu Val Arg Ser Lys Phe Ile Gln Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ser Lys Val Ile Leu Asn Ala Leu Gln Asp Tyr Phe Lys Ile 
    690                 695                 700                 


Ser Gly Ile Gln Thr Lys Val Ser Val Val Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg His Lys Trp Gly Ile Glu Lys Thr Arg Glu Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Arg 
            740                 745                 750         


Leu Trp Lys Lys Gln Glu Ser Pro Leu Val Val Asp Tyr Gln Glu Gly 
        755                 760                 765             


Arg Gln Val Asp Leu Glu Thr Gly Glu Ile Leu Glu Leu Thr Asp Glu 
    770                 775                 780                 


Gln Tyr Lys Glu Leu Val Tyr Gln Pro Pro Tyr Gln Gly Phe Val Asn 
785                 790                 795                 800 


Thr Ile Ser Ser Ser Ala Phe Asp Asn Glu Ile Leu Phe Ser Tyr Gln 
                805                 810                 815     


Val Asp Ser Lys Val Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala 
            820                 825                 830         


Thr Arg Asn Ala Gln Leu Gly Lys Asp Lys Thr Glu Gly Ile Tyr Val 
        835                 840                 845             


Leu Gly Lys Ile Lys Asp Ile Tyr Thr Gln Ala Gly Tyr Glu Ala Phe 
    850                 855                 860                 


Leu Lys Arg Tyr Thr Lys Asp Lys Thr Ser Phe Leu Met Tyr His Lys 
865                 870                 875                 880 


Asp Leu Asp Thr Trp Glu Lys Val Ile Glu Ile Ile Leu Arg Asp Tyr 
                885                 890                 895     


Arg Glu Tyr Asp Glu Lys Gly Lys Glu Ile Gly Asn Pro Phe Glu Arg 
            900                 905                 910         


Tyr Arg Arg Glu Asn Gly Tyr Val Lys Lys Tyr Ser Arg Lys Gly Asn 
        915                 920                 925             


Gly Thr Ala Ile Lys Ser Leu Lys Tyr Tyr Asp Asn Lys Leu Gly Asn 
    930                 935                 940                 


His Ile Asp Ile Thr Pro Glu Asn Ser Arg Asn Ala Val Val Leu Gln 
945                 950                 955                 960 


Ser Leu Lys Pro Trp Arg Thr Asp Val Tyr Phe Asn Lys Glu Thr Gly 
                965                 970                 975     


Lys Tyr Glu Phe Leu Gly Ile Lys Tyr Ser Asp Leu Ser Phe Glu Lys 
            980                 985                 990         


Gly Thr Gly Glu Tyr Gly Ile Ser  Gln Glu Lys Tyr Asp  Ser Ile Lys 
        995                 1000                 1005             


Ile Ala  Glu Gly Val Ala Lys  Lys Ser Ile Phe Lys  Phe Thr Leu 
    1010                 1015                 1020             


Tyr Lys  Gln Asp Leu Leu Phe  Ile Lys Asp Ile Glu  Asn Asn Phe 
    1025                 1030                 1035             


Gly Lys  Leu Leu Arg Phe Thr  Ser Lys Asn Asp Thr  Ser Lys His 
    1040                 1045                 1050             


Tyr Val  Glu Leu Lys Pro Tyr  Asp Lys Asn Lys Phe  Gly Thr Glu 
    1055                 1060                 1065             


Glu Pro  Leu Leu Pro Val Leu  Gly Asn Val Ala Lys  Ser Gly Gln 
    1070                 1075                 1080             


Cys Ile  Lys Gly Leu Asn Lys  Ser Asn Ile Ser Ile  Tyr Lys Val 
    1085                 1090                 1095             


Arg Thr  Asp Ile Leu Gly Tyr  Arg His Phe Ile Lys  Gln Glu Gly 
    1100                 1105                 1110             


Glu His  Pro Gln Leu Lys Phe  Lys Lys 
    1115                 1120         


<210> 584
<211> 1122
<212> PRT
<213> Streptococcus suis

<400> 584
Met Ser Asn Gly Lys Ile Leu Gly Leu Asp Ile Gly Ile Ala Ser Val 
1               5                   10                  15      


Gly Val Gly Val Ile Asp Ala Gln Thr Gly Glu Ile Ile His Ala Ser 
            20                  25                  30          


Ser Arg Ile Phe Pro Ser Ala Asn Ala Ala Asn Asn Ala Glu Arg Arg 
        35                  40                  45              


Thr Phe Arg Gly Ser Arg Arg Leu Ile Arg Arg Lys Lys His Arg Ile 
    50                  55                  60                  


Lys Arg Leu Asp Asp Leu Phe Asn Asp Phe His Ile Asn Leu Asp Gly 
65                  70                  75                  80  


Glu Met Ser Thr Asp Asn Pro Tyr Val Leu Arg Val Lys Gly Leu Ser 
                85                  90                  95      


Gln Lys Leu Thr Val Glu Glu Leu Tyr Ile Ser Ile Lys Asn Ile Met 
            100                 105                 110         


Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Glu Ser Asp Asn Glu 
        115                 120                 125             


Ala Gly Arg Ser Asp Tyr Ala Lys Ala Ile Glu Arg Asn Arg Gln Leu 
    130                 135                 140                 


Leu Thr Ser Lys Thr Pro Gly Glu Ile Gln Leu Glu Arg Leu Glu Lys 
145                 150                 155                 160 


Tyr Gly Gln Leu Arg Gly Asn Phe Thr Ile Ile Asp Glu Glu Gly Gln 
                165                 170                 175     


Ser Gln Gln Ile Ile Asn Val Phe Ser Thr Ser Asp Tyr Val Lys Glu 
            180                 185                 190         


Val Glu Lys Ile Leu Asp Cys Gln Lys Met Tyr His Lys Phe Ile Ser 
        195                 200                 205             


Asp Glu Phe Cys Asp Lys Leu Ile Glu Leu Leu Arg Glu Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr Val Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Ile 
225                 230                 235                 240 


Tyr Arg Thr Asp Gly Thr Thr Leu Glu Asn Leu Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Asp Gln Tyr Arg Ser Ser Arg Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Phe Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Gln Glu Gln Lys Glu Phe Leu 
    290                 295                 300                 


Val Asn Tyr Ala Lys Glu Thr Ser Val Leu Gly Ala Gly Lys Ile Leu 
305                 310                 315                 320 


Gln Gln Ile Ala Lys Leu Ala Asp Cys Lys Val Glu Asp Ile Arg Gly 
                325                 330                 335     


Tyr Arg Leu Asp Asn Lys Asp Lys Pro Glu Leu His Thr Phe Glu Thr 
            340                 345                 350         


Tyr Arg Ala Met Lys Gly Leu Val Pro Leu Val Asp Ile Gly Val Leu 
        355                 360                 365             


Ser Arg Glu Gln Leu Asp Ile Leu Ala Asp Ile Leu Thr Leu Asn Thr 
    370                 375                 380                 


Asp Phe Glu Gly Ile Arg Glu Ala Leu Lys Lys Gln Leu Pro Asn Val 
385                 390                 395                 400 


Phe Asp Glu Lys Gln Val Lys Gly Leu Ala Ser Phe Arg Lys Ser Lys 
                405                 410                 415     


Ser Gln Leu Phe Ala Lys Gly Trp His Asn Leu Ser Gln Lys Ile Met 
            420                 425                 430         


Leu Glu Val Ile Pro Glu Leu Tyr Ala Thr Ser Asp Glu Gln Met Thr 
        435                 440                 445             


Ile Leu Thr Arg Leu Gly Lys Phe Glu Lys Ser Ser Val Ala Glu Tyr 
    450                 455                 460                 


Pro Ser Ser Ile Asn Val Asp Glu Ile Thr Asp Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ala Lys Ser Ile Arg Gln Thr Ile Lys Ile Ile Asn Ala Ser 
                485                 490                 495     


Ile Lys Lys Trp Asp Glu Phe Asp Gln Ile Val Ile Glu Met Pro Arg 
            500                 505                 510         


Asp Arg Asn Glu Asp Glu Glu Lys Lys Arg Ile Ala Asp Gly Gln Lys 
        515                 520                 525             


Ala Asn Ala Lys Glu Lys Ala Asp Ser Ile Leu Arg Ala Ala Glu Leu 
    530                 535                 540                 


Tyr Cys Ala Gly Lys Val Leu Pro Asp Tyr Val Tyr Asn Gly His Asn 
545                 550                 555                 560 


Gln Leu Ala Thr Lys Ile Arg Leu Trp Tyr Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Ile Tyr Thr Gly Gln Pro Ile Ser Ile His Asp Leu Ile His Asn Gln 
            580                 585                 590         


Asn Gln Tyr Glu Ile Asp His Ile Leu Pro Leu Ser Leu Thr Phe Asp 
        595                 600                 605             


Asp Ser Leu Ser Asn Lys Val Leu Val Leu Ala Thr Ala Asn Gln Glu 
    610                 615                 620                 


Lys Ala Gln Arg Thr Pro Tyr Asn Tyr Leu Lys Ser Ala Thr Ser Ala 
625                 630                 635                 640 


Trp Ser Tyr Arg Glu Phe Lys Asp Tyr Val Thr Lys Arg Lys Gly Ile 
                645                 650                 655     


Gly Lys Lys Lys Cys Glu Tyr Leu Thr Phe Glu Glu Asp Ile Asn Gly 
            660                 665                 670         


Phe Glu Val Arg Ser Lys Phe Ile Gln Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ser Lys Val Ile Leu Asn Ala Leu Gln Asp Tyr Phe Lys Ile 
    690                 695                 700                 


Ser Gly Ile Gln Thr Lys Val Ser Val Val Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg His Lys Trp Gly Ile Glu Lys Thr Arg Glu Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Arg 
            740                 745                 750         


Leu Trp Lys Lys Gln Glu Ser Pro Leu Val Val Asp Tyr Gln Glu Gly 
        755                 760                 765             


Arg Gln Val Asp Leu Glu Thr Gly Glu Ile Leu Glu Leu Thr Asp Glu 
    770                 775                 780                 


Gln Tyr Lys Glu Leu Val Tyr Gln Pro Pro Tyr Gln Gly Phe Val Asn 
785                 790                 795                 800 


Thr Ile Ser Ser Ser Ala Phe Asp Asn Glu Ile Leu Phe Ser Tyr Gln 
                805                 810                 815     


Val Asp Ser Lys Val Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala 
            820                 825                 830         


Thr Arg Asn Ala Gln Leu Gly Lys Asp Lys Thr Glu Gly Ile Tyr Val 
        835                 840                 845             


Leu Gly Lys Ile Lys Asp Ile Tyr Thr Gln Ala Gly Tyr Glu Ala Phe 
    850                 855                 860                 


Leu Lys Arg Tyr Thr Lys Asp Lys Thr Ser Phe Leu Met Tyr His Lys 
865                 870                 875                 880 


Asp Leu Asp Thr Trp Glu Lys Val Ile Glu Ile Ile Leu Arg Asp Tyr 
                885                 890                 895     


Arg Glu Tyr Asp Glu Lys Gly Lys Glu Ile Gly Asn Pro Phe Glu Arg 
            900                 905                 910         


Tyr Arg Arg Glu Asn Gly Tyr Val Lys Lys Tyr Ser Arg Lys Gly Asn 
        915                 920                 925             


Gly Thr Ala Ile Lys Ser Leu Lys Tyr Tyr Asp Asn Lys Leu Gly Asn 
    930                 935                 940                 


His Ile Asp Ile Thr Pro Glu Asn Ser Arg Asn Ala Val Val Leu Gln 
945                 950                 955                 960 


Ser Leu Lys Pro Trp Arg Thr Asp Val Tyr Phe Asn Lys Glu Thr Gly 
                965                 970                 975     


Lys Tyr Glu Phe Leu Gly Ile Lys Tyr Ser Asp Leu Ser Phe Glu Lys 
            980                 985                 990         


Gly Thr Gly Glu Tyr Gly Ile Ser  Gln Glu Lys Tyr Asp  Ser Ile Lys 
        995                 1000                 1005             


Ile Ala  Glu Gly Val Ala Lys  Lys Ser Ile Phe Lys  Phe Thr Leu 
    1010                 1015                 1020             


Tyr Lys  Gln Asp Leu Leu Phe  Ile Lys Asp Ile Glu  Asn Asn Phe 
    1025                 1030                 1035             


Gly Lys  Leu Leu Arg Phe Thr  Ser Lys Asn Asp Thr  Ser Lys His 
    1040                 1045                 1050             


Tyr Val  Glu Leu Lys Pro Tyr  Asp Lys Asn Lys Phe  Gly Thr Glu 
    1055                 1060                 1065             


Glu Pro  Leu Leu Pro Val Leu  Gly Asn Val Ala Lys  Ser Gly Gln 
    1070                 1075                 1080             


Cys Ile  Lys Gly Leu Asn Lys  Ser Asn Ile Ser Ile  Tyr Lys Val 
    1085                 1090                 1095             


Arg Thr  Asp Ile Leu Gly Tyr  Arg His Phe Ile Lys  Gln Glu Gly 
    1100                 1105                 1110             


Glu His  Pro Gln Leu Lys Phe  Lys Lys 
    1115                 1120         


<210> 585
<211> 1381
<212> PRT
<213> Streptococcus suis

<400> 585
Met Val Lys Lys Lys Tyr Ala Ile Gly Ile Asp Ile Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ser Ile Val Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys 
            20                  25                  30          


Met Lys Val Phe Gly Asn Thr Glu Lys Arg Tyr Ile Lys Lys Asn Leu 
        35                  40                  45              


Leu Gly Thr Leu Leu Phe Asp Glu Gly Asn Thr Ala Glu Asn Arg Arg 
    50                  55                  60                  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Glu Ile Phe Ala Glu Glu Ile Asn Lys Ile Asp Asp 
                85                  90                  95      


Ser Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Ile Val Glu Asp Lys 
            100                 105                 110         


Gln Gly Ser Lys His Pro Ile Phe Gly Thr Leu Gln Glu Glu Lys Glu 
        115                 120                 125             


Tyr His Lys Gln Phe Pro Thr Ile Tyr His Leu Arg Lys Gln Leu Ala 
    130                 135                 140                 


Asp Ser Ser Gln Lys Ala Asp Ile Arg Leu Ile Tyr Leu Ala Leu Ala 
145                 150                 155                 160 


His Ile Ile Lys Tyr Arg Gly His Phe Leu Phe Glu Gly Asp Leu Lys 
                165                 170                 175     


Ser Glu Asn Lys Asp Val Gln His Leu Phe Asn Asp Phe Val Glu Met 
            180                 185                 190         


Phe Asp Lys Thr Val Glu Gly Ser Tyr Leu Ser Glu Asn Leu Pro Asn 
        195                 200                 205             


Val Ala Asp Val Leu Val Glu Lys Val Ser Lys Ser Arg Arg Leu Glu 
    210                 215                 220                 


Asn Ile Leu His Tyr Phe Pro Asn Glu Lys Lys Asn Gly Leu Phe Gly 
225                 230                 235                 240 


Asn Phe Leu Ala Leu Ala Leu Gly Leu Gln Pro Asn Phe Lys Thr Asn 
                245                 250                 255     


Phe Glu Leu Ala Glu Asp Ala Lys Ile Gln Phe Ser Lys Glu Thr Tyr 
            260                 265                 270         


Glu Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala 
        275                 280                 285             


Asp Leu Phe Ile Ala Thr Lys Ser Leu Tyr Asp Gly Ile Leu Leu Ala 
    290                 295                 300                 


Gly Ile Leu Ser Thr Thr Asp Ser Thr Thr Lys Ala Pro Leu Ser Ser 
305                 310                 315                 320 


Ser Met Val Asn Arg Tyr Glu Glu His Gln Lys Asp Leu Ala Leu Leu 
                325                 330                 335     


Lys Asn Phe Ile His Gln Asn Leu Ser Asp Ser Tyr Lys Glu Val Phe 
            340                 345                 350         


Asn Asp Lys Leu Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 
        355                 360                 365             


Thr Gln Glu Asn Phe Tyr Arg Phe Ile Lys Lys Ala Ile Glu Lys Ile 
    370                 375                 380                 


Glu Gly Ser Asn Tyr Phe Ile Asp Lys Ile Asp Arg Glu Asp Phe Leu 
385                 390                 395                 400 


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
                405                 410                 415     


Leu Gln Glu Met His Ala Ile Ile Arg Arg Gln Ala Glu Phe Tyr Pro 
            420                 425                 430         


Phe Leu Val Glu Asn Gln Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg 
        435                 440                 445             


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Glu Phe Ala 
    450                 455                 460                 


Trp Leu Asn Arg Lys Ser Asp Glu Lys Ile Arg Pro Trp Asn Phe Asp 
465                 470                 475                 480 


Glu Met Val Asp Lys Glu Thr Ser Ala Glu Asn Phe Ile Thr Arg Met 
                485                 490                 495     


Thr Asn Tyr Asp Arg Tyr Leu Pro Asp Gln Lys Val Leu Pro Lys His 
            500                 505                 510         


Ser Leu Leu Tyr Glu Lys Phe Ala Val Tyr Asn Glu Leu Thr Lys Val 
        515                 520                 525             


Lys Phe Ile Ala Glu Gly Met Arg Asp Tyr Gln Phe Leu Asp Ser Gly 
    530                 535                 540                 


Gln Lys Lys Asp Ile Val Lys Thr Leu Phe Lys Thr Lys Arg Lys Val 
545                 550                 555                 560 


Thr Ala Lys Asp Ile Lys Ala Tyr Leu Glu Asn Ser Asn Gly Tyr Ala 
                565                 570                 575     


Gly Val Glu Leu Lys Gly Leu Glu Glu Gln Phe Asn Ala Ser Leu Pro 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Leu Arg Asp Lys Ala Phe Ile Asp 
        595                 600                 605             


Ala Glu Glu Asn Gln Glu Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Lys Tyr Lys 
625                 630                 635                 640 


Asp Ile Leu Thr Glu Glu Gln Arg Lys Lys Leu Glu Arg Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile Leu Asp 
            660                 665                 670         


Lys Val Thr Arg Lys Thr Ile Leu Gly Tyr Leu Ile Asp Asp Gly Thr 
        675                 680                 685             


Ser Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Asp Thr Leu Ser Phe 
    690                 695                 700                 


Val Asp Glu Ile Arg Leu Ala Gln Gly Ser Gly Glu Ala Glu Asp Tyr 
705                 710                 715                 720 


Arg Ala Glu Val Gln Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Ser Leu Lys Ile Val Asp Glu Leu Ile Glu Val Met Gly 
            740                 745                 750         


Tyr Glu Pro Glu His Ile Val Val Glu Met Ala Arg Glu Asn Gln Phe 
        755                 760                 765             


Thr Asn Gln Gly Arg Arg Asn Ser Gln Gln Arg Ile Asn Arg Leu Glu 
    770                 775                 780                 


Asn Ala Leu Lys Asp Phe Gly Ser Lys Ile Leu Glu Glu Gln Lys Pro 
785                 790                 795                 800 


Tyr Gly Val Ser Lys Val Asn Asn Ile His Leu Gln Ser Asp Arg Leu 
                805                 810                 815     


Phe Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Asp Glu Glu 
            820                 825                 830         


Leu Asp Ile Asp His Leu Ser Glu Tyr Asp Ile Asp His Ile Ile Pro 
        835                 840                 845             


Gln Ala Phe Ile Lys Asp Asp Ser Leu Asp Asn Lys Val Leu Thr Lys 
    850                 855                 860                 


Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Met Glu Ile 
865                 870                 875                 880 


Val His Asn Arg Lys Asn Phe Trp Arg Gln Leu Leu Lys Ser Lys Leu 
                885                 890                 895     


Ile Ser Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 
            900                 905                 910         


Leu Thr Asn Glu Asp Lys Ala Arg Phe Ile Gln Arg Gln Leu Val Glu 
        915                 920                 925             


Thr Arg Gln Ile Thr Lys His Val Ala Arg Met Leu Asp Thr Arg Phe 
    930                 935                 940                 


Asn Thr Lys Leu Asp Glu Ala Gly Asn Arg Ile Arg Asp Pro Lys Val 
945                 950                 955                 960 


Asn Ile Ile Thr Leu Lys Ser Asn Leu Val Ser Gln Phe Arg Lys Asp 
                965                 970                 975     


Tyr Gln Leu Tyr Lys Ile Arg Glu Ile Asn Asn Tyr His His Ala His 
            980                 985                 990         


Asp Ala Tyr Ile Asn Ala Val Val  Ala Thr Ala Leu Leu  Lys Lys Tyr 
        995                 1000                 1005             


Pro Gln  Leu Ala Pro Glu Phe  Val Tyr Gly Glu Tyr  Pro Thr Tyr 
    1010                 1015                 1020             


Asn Ser  Tyr Asn Ser Arg Lys  Ser Ala Thr Glu Lys  Val Leu Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Arg Ile Val  Val His Ser 
    1040                 1045                 1050             


Lys Thr  Gly Glu Val Arg Ile  Arg Pro Val Ile Glu  Val Asn Lys 
    1055                 1060                 1065             


Glu Thr  Gly Glu Ile Val Trp  Asp Lys Lys Ser Asp  Phe Arg Thr 
    1070                 1075                 1080             


Val Arg  Lys Val Leu Ser Tyr  Pro Gln Val Asn Val  Val Lys Lys 
    1085                 1090                 1095             


Thr Glu  Val Gln Asn His Gly  Leu Asp Arg Gly Lys  Pro Lys Gly 
    1100                 1105                 1110             


Phe Tyr  Asn Ala Asn Leu Ser  Pro Arg Pro Lys Glu  Gly Ser Val 
    1115                 1120                 1125             


Glu Asn  Leu Val Pro Ala Lys  Gln Ser Phe Asp Thr  Lys Arg Tyr 
    1130                 1135                 1140             


Gly Gly  Tyr Ala Gly Ile Ser  Asn Ser Tyr Ala Val  Leu Val Asn 
    1145                 1150                 1155             


Gly Ile  Ile Glu Lys Gly Lys  Lys Lys Ser Lys Ala  Glu Val Thr 
    1160                 1165                 1170             


Glu Phe  Gln Gly Ile Ser Ile  Leu Ala Arg Lys Asp  Phe Asp Lys 
    1175                 1180                 1185             


Asn Pro  Lys Gln Tyr Leu Leu  Asn Leu Gly Tyr Lys  Asp Ile Lys 
    1190                 1195                 1200             


Ser Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn 
    1205                 1210                 1215             


Gly Ser  Arg Arg Met Leu Ala  Ser Ile Leu Ser Thr  Asn Asn Lys 
    1220                 1225                 1230             


Arg Gly  Glu Ile His Lys Gly  Asn Glu Met Tyr Leu  Pro Asp Lys 
    1235                 1240                 1245             


Phe Val  Thr Leu Leu Tyr His  Ala Met Arg Val Asn  Arg Thr Leu 
    1250                 1255                 1260             


Glu Pro  Gly His Lys Lys Tyr  Val Glu Thr His Arg  His Val Phe 
    1265                 1270                 1275             


Asp Glu  Leu Leu Ile Tyr Ile  Leu Glu Tyr Asn Glu  Lys Ile Val 
    1280                 1285                 1290             


Gly Ala  Lys Ala Asn Gly Lys  Arg Ile Val Glu Ala  Tyr Ser Ala 
    1295                 1300                 1305             


Arg Lys  Asp Thr Asp Asn Leu  Glu Glu Leu Cys Asn  Ser Phe Ile 
    1310                 1315                 1320             


Asn Leu  Leu Asn Leu Thr Ala  Leu Gly Ser Ala Val  Asp Phe Glu 
    1325                 1330                 1335             


Phe Leu  Gly Thr Lys Ile Pro  Arg Tyr Arg Asp Tyr  Thr Pro Ser 
    1340                 1345                 1350             


Ser Leu  Leu Lys Ala Thr Leu  Ile His Gln Ser Val  Thr Gly Leu 
    1355                 1360                 1365             


Tyr Glu  Thr Arg Ile Asp Leu  Ser Lys Leu Gly Gly  Asp 
    1370                 1375                 1380     


<210> 586
<211> 1122
<212> PRT
<213> Streptococcus suis

<400> 586
Met Ser Asn Gly Lys Ile Leu Gly Leu Asp Ile Gly Ile Ala Ser Val 
1               5                   10                  15      


Gly Val Gly Val Ile Asp Ala Gln Thr Gly Glu Ile Ile His Ala Ser 
            20                  25                  30          


Ser Arg Ile Phe Pro Ser Ala Asn Ala Ala Asn Asn Ala Glu Arg Arg 
        35                  40                  45              


Thr Phe Arg Gly Ser Arg Arg Leu Ile Arg Arg Lys Lys His Arg Ile 
    50                  55                  60                  


Lys Arg Leu Asp Asp Leu Phe Asn Asp Phe His Ile Asn Leu Asp Gly 
65                  70                  75                  80  


Glu Met Ser Thr Asp Asn Pro Tyr Val Leu Arg Val Lys Gly Leu Ser 
                85                  90                  95      


Gln Lys Leu Thr Val Glu Glu Leu Tyr Ile Ser Ile Lys Asn Ile Met 
            100                 105                 110         


Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Glu Ser Asp Asn Glu 
        115                 120                 125             


Ala Gly Arg Ser Asp Tyr Ala Lys Ala Ile Glu Arg Asn Arg Gln Leu 
    130                 135                 140                 


Leu Thr Ser Lys Thr Pro Gly Glu Ile Gln Leu Glu Arg Leu Glu Lys 
145                 150                 155                 160 


Tyr Gly Gln Leu Arg Gly Asn Phe Thr Ile Ile Asp Glu Glu Gly Gln 
                165                 170                 175     


Ser Gln Gln Ile Ile Asn Val Phe Ser Thr Ser Asp Tyr Val Lys Glu 
            180                 185                 190         


Val Glu Lys Ile Leu Asp Cys Gln Lys Met Tyr His Lys Phe Ile Ser 
        195                 200                 205             


Asp Glu Phe Cys Asp Lys Leu Ile Glu Leu Leu Arg Glu Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr Val Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Ile 
225                 230                 235                 240 


Tyr Arg Thr Asp Gly Thr Thr Leu Glu Asn Leu Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Asp Gln Tyr Arg Ser Ser Arg Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Phe Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Gln Glu Gln Lys Glu Phe Leu 
    290                 295                 300                 


Val Asn Tyr Ala Lys Glu Thr Ser Val Leu Gly Ala Gly Lys Ile Leu 
305                 310                 315                 320 


Gln Gln Ile Ala Lys Leu Ala Asp Cys Lys Val Glu Asp Ile Arg Gly 
                325                 330                 335     


Tyr Arg Leu Asp Asn Lys Asp Lys Pro Glu Leu His Thr Phe Glu Thr 
            340                 345                 350         


Tyr Arg Ala Met Lys Gly Leu Val Pro Leu Val Asp Ile Gly Val Leu 
        355                 360                 365             


Ser Arg Glu Gln Leu Asp Ile Leu Ala Asp Ile Leu Thr Leu Asn Thr 
    370                 375                 380                 


Asp Phe Glu Gly Ile Arg Glu Ala Leu Lys Lys Gln Leu Pro Asn Val 
385                 390                 395                 400 


Phe Asp Glu Lys Gln Val Lys Gly Leu Ala Ser Phe Arg Lys Ser Lys 
                405                 410                 415     


Ser Gln Leu Phe Ala Lys Gly Trp His Asn Leu Ser Gln Lys Ile Met 
            420                 425                 430         


Leu Glu Val Ile Pro Glu Leu Tyr Ala Thr Ser Asp Glu Gln Met Thr 
        435                 440                 445             


Ile Leu Thr Arg Leu Gly Lys Phe Glu Lys Ser Ser Val Ala Glu Tyr 
    450                 455                 460                 


Pro Ser Ser Ile Asn Val Asp Glu Ile Thr Asp Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ala Lys Ser Ile Arg Gln Thr Ile Lys Ile Ile Asn Ala Ser 
                485                 490                 495     


Ile Lys Lys Trp Gly Glu Phe Asp Gln Ile Val Ile Glu Met Pro Arg 
            500                 505                 510         


Asp Arg Asn Glu Asp Glu Glu Lys Lys Arg Ile Ala Asp Gly Gln Lys 
        515                 520                 525             


Ala Asn Ala Lys Glu Lys Ala Asp Ser Ile Leu Arg Ala Ala Glu Leu 
    530                 535                 540                 


Tyr Cys Ala Gly Lys Val Leu Pro Asp Tyr Val Tyr Asn Gly His Asn 
545                 550                 555                 560 


Gln Leu Ala Thr Lys Ile Arg Leu Trp Tyr Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Ile Tyr Thr Gly Gln Pro Ile Ser Ile His Asp Leu Ile His Asn Gln 
            580                 585                 590         


Asn Gln Tyr Glu Ile Asp His Ile Leu Pro Leu Ser Leu Thr Phe Asp 
        595                 600                 605             


Asp Ser Leu Ser Asn Lys Val Leu Val Leu Ala Thr Ala Asn Gln Glu 
    610                 615                 620                 


Lys Ala Gln Arg Thr Pro Tyr Asn Tyr Leu Lys Ser Ala Thr Ser Ala 
625                 630                 635                 640 


Trp Ser Tyr Arg Glu Phe Lys Asp Tyr Val Thr Lys Arg Lys Gly Ile 
                645                 650                 655     


Gly Lys Lys Lys Cys Glu Tyr Leu Thr Phe Glu Glu Asp Ile Asn Gly 
            660                 665                 670         


Phe Glu Val Arg Ser Lys Phe Ile Gln Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ser Lys Val Ile Leu Asn Ala Leu Gln Asp Tyr Phe Lys Ile 
    690                 695                 700                 


Ser Gly Ile Gln Thr Lys Val Ser Val Val Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg His Lys Trp Gly Ile Glu Lys Thr Arg Glu Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Arg 
            740                 745                 750         


Leu Trp Lys Lys Gln Glu Ser Pro Leu Val Val Asp Tyr Gln Glu Gly 
        755                 760                 765             


Arg Gln Val Asp Leu Glu Thr Gly Glu Ile Leu Glu Leu Thr Asp Glu 
    770                 775                 780                 


Gln Tyr Lys Glu Leu Val Tyr Gln Pro Pro Tyr Gln Gly Phe Val Asn 
785                 790                 795                 800 


Thr Ile Ser Ser Ser Ala Phe Asp Asn Glu Ile Leu Phe Ser Tyr Gln 
                805                 810                 815     


Val Asp Ser Lys Val Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala 
            820                 825                 830         


Thr Arg Asn Ala Gln Leu Gly Lys Asp Lys Thr Glu Gly Ile Tyr Val 
        835                 840                 845             


Leu Gly Lys Ile Lys Asp Ile Tyr Thr Gln Ala Gly Tyr Glu Ala Phe 
    850                 855                 860                 


Leu Lys Arg Tyr Thr Lys Asp Lys Thr Ser Phe Leu Met Tyr His Lys 
865                 870                 875                 880 


Asp Leu Asp Thr Trp Glu Lys Val Ile Glu Ile Ile Leu Arg Asp Tyr 
                885                 890                 895     


Arg Glu Tyr Asp Glu Lys Gly Lys Glu Ile Gly Asn Pro Phe Glu Arg 
            900                 905                 910         


Tyr Arg Arg Glu Asn Gly Tyr Val Lys Lys Tyr Ser Arg Lys Gly Asn 
        915                 920                 925             


Gly Thr Ala Ile Lys Ser Leu Lys Tyr Tyr Asp Asn Lys Leu Gly Asn 
    930                 935                 940                 


His Ile Asp Ile Thr Pro Glu Asn Ser Arg Asn Ala Val Val Leu Gln 
945                 950                 955                 960 


Ser Leu Lys Pro Trp Arg Thr Asp Val Tyr Phe Asn Lys Glu Thr Gly 
                965                 970                 975     


Lys Tyr Glu Phe Leu Gly Ile Lys Tyr Ser Asp Leu Ser Phe Glu Lys 
            980                 985                 990         


Gly Thr Gly Glu Tyr Gly Ile Ser  Gln Glu Lys Tyr Asp  Ser Ile Lys 
        995                 1000                 1005             


Ile Ala  Glu Gly Val Ala Lys  Lys Ser Ile Phe Lys  Phe Thr Leu 
    1010                 1015                 1020             


Tyr Lys  Gln Asp Leu Leu Phe  Ile Lys Asp Ile Glu  Asn Asn Phe 
    1025                 1030                 1035             


Gly Lys  Leu Leu Arg Phe Thr  Ser Lys Asn Asp Thr  Ser Lys His 
    1040                 1045                 1050             


Tyr Val  Glu Leu Lys Pro Tyr  Asp Lys Asn Lys Phe  Gly Thr Glu 
    1055                 1060                 1065             


Glu Pro  Leu Leu Pro Val Leu  Gly Asn Val Ala Lys  Ser Gly Gln 
    1070                 1075                 1080             


Cys Ile  Lys Gly Leu Asn Lys  Ser Asn Ile Ser Ile  Tyr Lys Val 
    1085                 1090                 1095             


Arg Thr  Asp Ile Leu Gly Tyr  Arg His Phe Ile Lys  Gln Glu Gly 
    1100                 1105                 1110             


Glu His  Pro Gln Leu Lys Phe  Lys Lys 
    1115                 1120         


<210> 587
<211> 1388
<212> PRT
<213> Streptococcus thermophilus

<400> 587
Met Thr Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asn Tyr Lys Val Pro Ser Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Ser Lys Lys Tyr Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Val Leu Leu Phe Asp Ser Gly Ile Thr Ala Glu Gly Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Thr Glu Met Ala Thr Leu Asp Asp Ala 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Pro Asp Asp Lys Arg 
            100                 105                 110         


Asp Ser Lys Tyr Pro Ile Phe Gly Asn Leu Val Glu Glu Lys Val Tyr 
        115                 120                 125             


His Asp Glu Phe Pro Thr Ile Tyr His Leu Arg Lys Tyr Leu Ala Asp 
    130                 135                 140                 


Ser Thr Lys Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Phe Asn Ser 
                165                 170                 175     


Lys Asn Asn Asp Ile Gln Lys Asn Phe Gln Asp Phe Leu Asp Thr Tyr 
            180                 185                 190         


Asn Ala Ile Phe Glu Ser Asp Leu Ser Leu Glu Asn Ser Lys Gln Leu 
        195                 200                 205             


Glu Glu Ile Val Lys Asp Lys Ile Ser Lys Leu Glu Lys Lys Asp Arg 
    210                 215                 220                 


Ile Leu Lys Leu Phe Pro Gly Glu Lys Asn Ser Gly Ile Phe Ser Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Arg Lys Cys Phe 
                245                 250                 255     


Asn Leu Asp Glu Lys Ala Ser Leu His Phe Ser Lys Glu Ser Tyr Asp 
            260                 265                 270         


Glu Asp Leu Glu Thr Leu Leu Gly Tyr Ile Gly Asp Asp Tyr Ser Asp 
        275                 280                 285             


Val Phe Leu Lys Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Phe Leu Thr Val Thr Asp Asn Glu Thr Glu Ala Pro Leu Ser Ser Ala 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asn Glu His Lys Glu Asp Leu Ala Leu Leu Lys 
                325                 330                 335     


Glu Tyr Ile Arg Asn Ile Ser Leu Lys Thr Tyr Asn Glu Val Phe Lys 
            340                 345                 350         


Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Asp Phe Tyr Val Tyr Leu Lys Asn Leu Leu Ala Glu Phe Glu 
    370                 375                 380                 


Gly Ala Asp Tyr Phe Leu Glu Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Leu Asp Lys Gln Ala Lys Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Lys Asn Lys Glu Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Asp Phe Ala Trp 
    450                 455                 460                 


Ser Ile Arg Lys Arg Asn Glu Lys Ile Thr Pro Trp Asn Phe Glu Asp 
465                 470                 475                 480 


Val Ile Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Ser Phe Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Asn Val Tyr Asn Glu Leu Thr Lys Val Arg 
        515                 520                 525             


Phe Ile Ala Glu Ser Met Arg Asp Tyr Gln Phe Leu Asp Ser Lys Gln 
    530                 535                 540                 


Lys Lys Asp Ile Val Arg Leu Tyr Phe Lys Asp Lys Arg Lys Val Thr 
545                 550                 555                 560 


Asp Lys Asp Ile Ile Glu Tyr Leu His Ala Ile Tyr Gly Tyr Asp Gly 
                565                 570                 575     


Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ser Ser Leu Ser Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Asn Ile Ile Asn Asp Lys Glu Phe Leu Asp Asp 
        595                 600                 605             


Ser Ser Asn Glu Ala Ile Ile Glu Glu Ile Ile His Thr Leu Thr Ile 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ser Lys Phe Glu Asn 
625                 630                 635                 640 


Ile Phe Asp Lys Ser Val Leu Lys Lys Leu Ser Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asp Glu 
            660                 665                 670         


Lys Ser Gly Asn Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ile Ser 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ala Leu Ser Phe Lys 
    690                 695                 700                 


Lys Lys Ile Gln Lys Ala Gln Ile Ile Gly Asp Glu Asp Lys Gly Asn 
705                 710                 715                 720 


Ile Lys Glu Val Val Lys Ser Leu Pro Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly Gly Arg Lys Pro Glu Ser Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Tyr Thr Asn Gln Gly Lys Ser Asn Ser Gln Gln Arg Leu Lys Arg 
    770                 775                 780                 


Leu Glu Lys Ser Leu Lys Glu Leu Gly Ser Lys Ile Leu Lys Glu Asn 
785                 790                 795                 800 


Ile Pro Ala Lys Leu Ser Lys Ile Asp Asn Asn Ala Leu Gln Asn Asp 
                805                 810                 815     


Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly 
            820                 825                 830         


Asp Asp Leu Asp Ile Asp Arg Leu Ser Asn Tyr Asp Ile Asp His Ile 
        835                 840                 845             


Ile Pro Gln Ala Phe Leu Lys Asp Asn Ser Ile Asp Asn Lys Val Leu 
    850                 855                 860                 


Val Ser Ser Ala Ser Asn Arg Gly Lys Ser Asp Asp Phe Pro Ser Leu 
865                 870                 875                 880 


Glu Val Val Lys Lys Arg Lys Thr Phe Trp Tyr Gln Leu Leu Lys Ser 
                885                 890                 895     


Lys Leu Ile Ser Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 
            900                 905                 910         


Gly Gly Leu Leu Pro Glu Asp Lys Ala Gly Phe Ile Gln Arg Gln Leu 
        915                 920                 925             


Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Arg Leu Leu Asp Glu 
    930                 935                 940                 


Lys Phe Asn Asn Lys Lys Asp Glu Asn Asn Arg Ala Val Arg Thr Val 
945                 950                 955                 960 


Lys Ile Ile Thr Leu Lys Ser Thr Leu Val Ser Gln Phe Arg Lys Asp 
                965                 970                 975     


Phe Glu Leu Tyr Lys Val Arg Glu Ile Asn Asp Phe His His Ala His 
            980                 985                 990         


Asp Ala Tyr Leu Asn Ala Val Ile  Ala Ser Ala Leu Leu  Lys Lys Tyr 
        995                 1000                 1005             


Pro Lys  Leu Glu Pro Glu Phe  Val Tyr Gly Asp Tyr  Pro Lys Tyr 
    1010                 1015                 1020             


Asn Ser  Phe Arg Glu Arg Lys  Ser Ala Thr Glu Lys  Val Tyr Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Ile  Phe Lys Lys Ser Ile  Ser Leu Ala 
    1040                 1045                 1050             


Asp Gly  Arg Val Ile Glu Arg  Pro Leu Ile Glu Val  Asn Glu Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ser Val Trp Asn  Lys Glu Ser Asp Leu  Ala Thr Val 
    1070                 1075                 1080             


Arg Arg  Val Leu Ser Tyr Pro  Gln Val Asn Val Val  Lys Lys Val 
    1085                 1090                 1095             


Glu Glu  Gln Asn His Gly Leu  Asp Arg Gly Lys Pro  Lys Gly Leu 
    1100                 1105                 1110             


Phe Asn  Ala Asn Leu Ser Ser  Lys Pro Lys Pro Asn  Ser Asn Glu 
    1115                 1120                 1125             


Asn Leu  Val Gly Ala Lys Glu  Tyr Leu Asp Pro Lys  Lys Tyr Gly 
    1130                 1135                 1140             


Gly Tyr  Ala Gly Ile Ser Asn  Ser Phe Ala Val Leu  Val Lys Gly 
    1145                 1150                 1155             


Thr Ile  Glu Lys Gly Ala Lys  Lys Lys Ile Thr Asn  Val Leu Glu 
    1160                 1165                 1170             


Phe Gln  Gly Ile Ser Ile Leu  Asp Arg Ile Asn Tyr  Arg Lys Asp 
    1175                 1180                 1185             


Lys Leu  Asn Phe Leu Leu Glu  Lys Gly Tyr Lys Asp  Ile Glu Leu 
    1190                 1195                 1200             


Ile Ile  Glu Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Ser Asp Gly 
    1205                 1210                 1215             


Ser Arg  Arg Met Leu Ala Ser  Ile Leu Ser Thr Asn  Asn Lys Arg 
    1220                 1225                 1230             


Gly Glu  Ile His Lys Gly Asn  Gln Ile Phe Leu Ser  Gln Lys Phe 
    1235                 1240                 1245             


Val Lys  Leu Leu Tyr His Ala  Lys Arg Ile Ser Asn  Thr Ile Asn 
    1250                 1255                 1260             


Glu Asn  His Arg Lys Tyr Val  Glu Asn His Lys Lys  Glu Phe Glu 
    1265                 1270                 1275             


Glu Leu  Phe Tyr Tyr Ile Leu  Glu Phe Asn Glu Asn  Tyr Val Gly 
    1280                 1285                 1290             


Ala Lys  Lys Asn Gly Lys Leu  Leu Asn Ser Ala Phe  Gln Ser Trp 
    1295                 1300                 1305             


Gln Asn  His Ser Ile Asp Glu  Leu Cys Ser Ser Phe  Ile Gly Pro 
    1310                 1315                 1320             


Thr Gly  Ser Glu Arg Lys Gly  Leu Phe Glu Leu Thr  Ser Arg Gly 
    1325                 1330                 1335             


Ser Ala  Ala Asp Phe Glu Phe  Leu Gly Val Lys Ile  Pro Arg Tyr 
    1340                 1345                 1350             


Arg Asp  Tyr Thr Pro Ser Ser  Leu Leu Lys Asp Ala  Thr Leu Ile 
    1355                 1360                 1365             


His Gln  Ser Val Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ala 
    1370                 1375                 1380             


Lys Leu  Gly Glu Gly 
    1385             


<210> 588
<211> 1128
<212> PRT
<213> Streptococcus thermophilus

<400> 588
Met Ser Asp Leu Val Leu Gly Leu Asp Ile Gly Ile Gly Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 
            20                  25                  30          


Arg Ile Phe Pro Ala Ala Gln Ala Glu Asn Asn Leu Val Arg Arg Thr 
        35                  40                  45              


Asn Arg Gln Gly Arg Arg Leu Thr Arg Arg Lys Lys His Arg Ile Val 
    50                  55                  60                  


Arg Leu Asn Arg Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 
65                  70                  75                  80  


Lys Ile Ser Ile Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu 
                85                  90                  95      


Thr Asp Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 
            100                 105                 110         


Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 
        115                 120                 125             


Asn Ser Ser Val Gly Asp Tyr Ala Gln Ile Val Lys Glu Asn Ser Lys 
    130                 135                 140                 


Gln Leu Glu Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Tyr Gln 
145                 150                 155                 160 


Thr Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Glu Lys Asp Gly Lys 
                165                 170                 175     


Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr Arg Ser Glu 
            180                 185                 190         


Ala Leu Arg Ile Leu Gln Thr Gln Gln Glu Phe Asn Pro Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Asn Arg Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Tyr Arg Thr Ser Gly Glu Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Glu Glu Phe Arg Ala Ala Lys Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Lys Glu Gln Lys Asn Gln Ile 
    290                 295                 300                 


Ile Asn Tyr Val Lys Asn Glu Lys Ala Met Gly Pro Ala Lys Leu Phe 
305                 310                 315                 320 


Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp Val Ala Asp Ile Lys Gly 
                325                 330                 335     


Tyr Arg Ile Asp Lys Ser Gly Lys Ala Glu Ile His Thr Phe Glu Ala 
            340                 345                 350         


Tyr Arg Lys Met Lys Thr Leu Glu Thr Leu Asp Ile Glu Gln Met Asp 
        355                 360                 365             


Arg Glu Thr Leu Asp Lys Leu Ala Tyr Val Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Gln Glu Ala Leu Glu His Glu Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Phe Ser Gln Lys Gln Val Asp Glu Leu Val Gln Phe Arg Lys Ala Asn 
                405                 410                 415     


Ser Ser Ile Phe Gly Lys Gly Trp His Asn Phe Ser Val Lys Leu Met 
            420                 425                 430         


Met Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr 
        435                 440                 445             


Ile Leu Thr Arg Leu Gly Lys Gln Lys Arg Leu Arg Leu Gln Ile Lys 
    450                 455                 460                 


Gln Asn Ile Ser Asn Lys Thr Lys Tyr Ile Asp Glu Lys Leu Leu Thr 
465                 470                 475                 480 


Glu Glu Ile Tyr Asn Pro Val Val Ala Lys Ser Val Arg Gln Ala Ile 
                485                 490                 495     


Lys Ile Val Asn Ala Ala Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile 
            500                 505                 510         


Val Ile Glu Met Ala Arg Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala 
        515                 520                 525             


Ile Gln Lys Ile Gln Lys Ala Asn Lys Asp Glu Lys Asp Ala Ala Met 
    530                 535                 540                 


Leu Lys Ala Ala Asn Gln Tyr Asn Gly Lys Ala Glu Leu Pro His Ser 
545                 550                 555                 560 


Val Phe His Gly His Lys Gln Leu Ala Thr Lys Ile Arg Leu Trp His 
                565                 570                 575     


Gln Gln Gly Glu Arg Cys Leu Tyr Thr Gly Lys Thr Ile Ser Ile His 
            580                 585                 590         


Asp Leu Ile Asn Asn Pro Asn Gln Phe Glu Val Asp His Ile Leu Pro 
        595                 600                 605             


Leu Ser Ile Thr Phe Asp Asp Ser Leu Ala Asn Lys Val Leu Val Tyr 
    610                 615                 620                 


Ala Thr Ala Asn Gln Glu Lys Gly Gln Arg Thr Pro Tyr Gln Ala Leu 
625                 630                 635                 640 


Asp Ser Met Asp Asp Ala Trp Ser Phe Arg Glu Leu Lys Ala Phe Val 
                645                 650                 655     


Arg Glu Ser Lys Thr Leu Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr 
            660                 665                 670         


Glu Glu Asp Ile Ser Lys Phe Asp Val Arg Lys Lys Phe Ile Glu Arg 
        675                 680                 685             


Asn Leu Val Asp Thr Arg Tyr Ala Ser Arg Val Val Leu Asn Ala Leu 
    690                 695                 700                 


Gln Glu His Phe Arg Ala His Lys Ile Asp Thr Lys Val Ser Val Val 
705                 710                 715                 720 


Arg Gly Gln Phe Thr Ser Gln Leu Arg Arg His Trp Gly Ile Glu Lys 
                725                 730                 735     


Thr Arg Asp Thr Tyr His His His Ala Val Asp Ala Leu Ile Ile Ala 
            740                 745                 750         


Ala Ser Ser Gln Leu Asn Leu Trp Lys Lys Gln Lys Asn Thr Leu Val 
        755                 760                 765             


Ser Tyr Ser Glu Glu Gln Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile 
    770                 775                 780                 


Ser Asp Asp Glu Tyr Lys Glu Ser Val Phe Lys Ala Pro Tyr Gln His 
785                 790                 795                 800 


Phe Val Asp Thr Leu Lys Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe 
                805                 810                 815     


Ser Tyr Gln Val Asp Ser Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr 
            820                 825                 830         


Ile Tyr Ala Thr Arg Gln Ala Lys Val Gly Lys Asp Lys Lys Asp Glu 
        835                 840                 845             


Thr Tyr Val Leu Gly Lys Ile Lys Asp Ile Tyr Thr Gln Asp Gly Tyr 
    850                 855                 860                 


Asp Ala Phe Met Lys Ile Tyr Lys Lys Asp Lys Ser Lys Phe Leu Met 
865                 870                 875                 880 


Tyr Arg His Asp Pro Gln Thr Phe Glu Lys Val Ile Glu Pro Ile Leu 
                885                 890                 895     


Glu Asn Tyr Pro Asn Lys Gln Met Asn Glu Lys Gly Lys Glu Val Pro 
            900                 905                 910         


Cys Asn Pro Phe Leu Lys Tyr Lys Glu Glu His Gly Tyr Ile Arg Lys 
        915                 920                 925             


Tyr Ser Lys Lys Gly Asn Gly Pro Glu Ile Lys Ser Leu Lys Tyr Tyr 
    930                 935                 940                 


Asp Ser Lys Leu Leu Gly Asn Pro Ile Asp Ile Thr Pro Glu Asn Ser 
945                 950                 955                 960 


Lys Asn Lys Val Val Leu Gln Ser Leu Lys Pro Trp Arg Thr Asp Val 
                965                 970                 975     


Tyr Phe Asn Lys Ala Thr Gly Lys Tyr Glu Ile Leu Gly Leu Lys Tyr 
            980                 985                 990         


Ala Asp Leu Gln Phe Glu Lys Gly  Thr Gly Thr Tyr Lys  Ile Ser Gln 
        995                 1000                 1005             


Glu Lys  Tyr Asn Asp Ile Lys  Lys Lys Glu Gly Val  Asp Ser Asp 
    1010                 1015                 1020             


Ser Glu  Phe Lys Phe Thr Leu  Tyr Lys Asn Asp Leu  Leu Leu Val 
    1025                 1030                 1035             


Lys Asp  Thr Glu Thr Lys Glu  Gln Gln Leu Phe Arg  Phe Leu Ser 
    1040                 1045                 1050             


Arg Thr  Leu Pro Lys Gln Lys  His Tyr Val Glu Leu  Lys Pro Tyr 
    1055                 1060                 1065             


Asp Lys  Gln Lys Phe Glu Gly  Gly Glu Ala Leu Ile  Lys Val Leu 
    1070                 1075                 1080             


Gly Asn  Val Ala Asn Gly Gly  Gln Cys Ile Lys Gly  Leu Ala Lys 
    1085                 1090                 1095             


Ser Asn  Ile Ser Ile Tyr Lys  Val Arg Thr Asp Val  Leu Gly Asn 
    1100                 1105                 1110             


Gln His  Ile Ile Lys Asn Glu  Gly Asp Lys Pro Lys  Leu Asp Phe 
    1115                 1120                 1125             


<210> 589
<211> 1121
<212> PRT
<213> Streptococcus thermophilus

<400> 589
Met Ser Asp Leu Val Leu Gly Leu Asp Ile Gly Ile Gly Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 
            20                  25                  30          


Arg Ile Phe Pro Ala Ala Gln Ala Glu Asn Asn Leu Val Arg Arg Thr 
        35                  40                  45              


Asn Arg Gln Gly Arg Arg Leu Thr Arg Arg Lys Lys His Arg Ile Val 
    50                  55                  60                  


Arg Leu Asn Arg Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 
65                  70                  75                  80  


Lys Ile Ser Ile Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu 
                85                  90                  95      


Thr Asp Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 
            100                 105                 110         


Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 
        115                 120                 125             


Asn Ser Ser Val Gly Asp Tyr Ala Gln Ile Val Lys Glu Asn Ser Lys 
    130                 135                 140                 


Gln Leu Glu Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Tyr Gln 
145                 150                 155                 160 


Thr Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Glu Lys Asp Gly Lys 
                165                 170                 175     


Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr Arg Ser Glu 
            180                 185                 190         


Ala Leu Arg Ile Leu Gln Thr Gln Gln Glu Phe Asn Pro Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Asn Arg Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Tyr Arg Thr Ser Gly Glu Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Asp Glu Phe Arg Ala Ala Lys Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Lys Glu Gln Lys Asn Gln Ile 
    290                 295                 300                 


Ile Asn Tyr Val Lys Asn Glu Lys Ala Met Gly Pro Ala Lys Leu Phe 
305                 310                 315                 320 


Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp Val Ala Asp Ile Lys Glu 
                325                 330                 335     


Tyr Arg Ile Asp Lys Ser Gly Lys Ala Glu Ile His Thr Phe Glu Ala 
            340                 345                 350         


Tyr Arg Lys Met Lys Thr Leu Glu Thr Leu Asp Ile Glu Gln Met Asp 
        355                 360                 365             


Arg Glu Thr Leu Asp Lys Leu Ala Tyr Val Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Gln Glu Ala Leu Glu His Glu Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Phe Ser Gln Lys Gln Val Asp Glu Leu Val Gln Phe Arg Lys Ala Asn 
                405                 410                 415     


Ser Ser Ile Phe Gly Lys Gly Trp His Asn Phe Ser Val Lys Leu Met 
            420                 425                 430         


Met Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr 
        435                 440                 445             


Ile Leu Thr Arg Leu Gly Lys Gln Lys Thr Thr Ser Ser Ser Asn Lys 
    450                 455                 460                 


Thr Lys Tyr Ile Asp Glu Lys Leu Leu Thr Glu Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Val Asn Ala Ala 
                485                 490                 495     


Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile Val Ile Glu Met Ala Arg 
            500                 505                 510         


Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala Ile Gln Lys Ile Gln Lys 
        515                 520                 525             


Ala Asn Lys Asp Glu Lys Asp Ala Ala Met Leu Lys Ala Ala Asn Gln 
    530                 535                 540                 


Tyr Asn Gly Lys Ala Glu Leu Pro His Ser Val Phe His Gly His Lys 
545                 550                 555                 560 


Gln Leu Ala Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Leu Tyr Thr Gly Lys Thr Ile Ser Ile His Asp Leu Ile Asn Asn Ser 
            580                 585                 590         


Asn Gln Phe Glu Val Asp His Ile Leu Pro Leu Ser Ile Thr Phe Asp 
        595                 600                 605             


Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ala Thr Ala Asn Gln Glu 
    610                 615                 620                 


Lys Gly Gln Arg Thr Pro Tyr Gln Ala Leu Asp Ser Met Asp Asp Ala 
625                 630                 635                 640 


Trp Ser Phe Arg Glu Leu Lys Ala Phe Val Arg Glu Ser Lys Thr Leu 
                645                 650                 655     


Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys 
            660                 665                 670         


Phe Asp Val Arg Lys Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ser Arg Val Val Leu Asn Ala Leu Gln Glu His Phe Arg Ala 
    690                 695                 700                 


His Lys Ile Asp Thr Lys Val Ser Val Val Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg Arg His Trp Gly Ile Glu Lys Thr Arg Asp Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ile Gln Leu Asn 
            740                 745                 750         


Leu Trp Lys Lys Gln Lys Asn Thr Leu Val Ser Tyr Ser Glu Asp Gln 
        755                 760                 765             


Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile Ser Asp Asp Glu Tyr Lys 
    770                 775                 780                 


Glu Ser Val Phe Lys Ala Pro Tyr Gln His Phe Val Asp Thr Leu Lys 
785                 790                 795                 800 


Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln Val Asp Ser 
                805                 810                 815     


Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg Gln 
            820                 825                 830         


Ala Lys Val Gly Lys Asp Lys Ala Asp Glu Thr Tyr Val Leu Gly Lys 
        835                 840                 845             


Ile Lys Asp Ile Tyr Thr Gln Asp Gly Tyr Asp Ala Phe Met Lys Ile 
    850                 855                 860                 


Tyr Lys Lys Asp Lys Ser Lys Phe Leu Met Tyr Arg His Asp Pro Gln 
865                 870                 875                 880 


Thr Phe Glu Lys Val Ile Glu Pro Ile Leu Glu Asn Tyr Pro Asn Lys 
                885                 890                 895     


Gln Ile Asn Glu Lys Gly Lys Glu Val Pro Val Asn Pro Phe Leu Lys 
            900                 905                 910         


Tyr Lys Glu Glu His Gly Tyr Ile Arg Lys Tyr Ser Lys Lys Gly Asn 
        915                 920                 925             


Gly Pro Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Ser Lys Leu Gly Asn 
    930                 935                 940                 


His Ile Asp Ile Thr Pro Lys Asp Ser Asn Asn Lys Val Val Leu Gln 
945                 950                 955                 960 


Ser Val Ser Pro Trp Arg Ala Asp Val Tyr Phe Asn Lys Thr Thr Gly 
                965                 970                 975     


Lys Tyr Glu Ile Leu Gly Leu Lys Tyr Ala Asp Leu Gln Phe Glu Lys 
            980                 985                 990         


Gly Thr Gly Thr Tyr Lys Ile Ser  Gln Glu Lys Tyr Asn  Asp Ile Lys 
        995                 1000                 1005             


Lys Lys  Glu Gly Val Asp Ser  Asp Ser Glu Phe Lys  Phe Thr Leu 
    1010                 1015                 1020             


Tyr Lys  Asn Asp Leu Leu Leu  Val Lys Asp Thr Glu  Thr Lys Glu 
    1025                 1030                 1035             


Gln Gln  Leu Phe Arg Phe Leu  Ser Arg Thr Met Pro  Lys Gln Lys 
    1040                 1045                 1050             


His Tyr  Val Glu Leu Lys Pro  Tyr Asp Lys Gln Lys  Phe Glu Gly 
    1055                 1060                 1065             


Gly Glu  Ala Leu Ile Lys Val  Leu Gly Asn Val Ala  Asn Ser Gly 
    1070                 1075                 1080             


Gln Cys  Lys Lys Gly Leu Gly  Lys Ser Asn Ile Ser  Ile Tyr Lys 
    1085                 1090                 1095             


Val Arg  Thr Asp Val Leu Gly  Asn Gln His Ile Ile  Lys Asn Glu 
    1100                 1105                 1110             


Gly Asp  Lys Pro Lys Leu Asp  Phe 
    1115                 1120     


<210> 590
<211> 1388
<212> PRT
<213> Streptococcus thermophilus

<400> 590
Met Thr Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Thr Thr Asp Asn Tyr Lys Val Pro Ser Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Ser Lys Lys Tyr Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Val Leu Leu Phe Asp Ser Gly Ile Thr Ala Glu Gly Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Thr Glu Met Ala Thr Leu Asp Asp Ala 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Pro Asp Asp Lys Arg 
            100                 105                 110         


Asp Ser Lys Tyr Pro Ile Phe Gly Asn Leu Val Glu Glu Lys Ala Tyr 
        115                 120                 125             


His Asp Glu Phe Pro Thr Ile Tyr His Leu Arg Lys Tyr Leu Ala Asp 
    130                 135                 140                 


Ser Thr Lys Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Phe Asn Ser 
                165                 170                 175     


Lys Asn Asn Asp Ile Gln Lys Asn Phe Gln Asp Phe Leu Asp Thr Tyr 
            180                 185                 190         


Asn Ala Ile Phe Glu Ser Asp Leu Ser Leu Glu Asn Ser Lys Gln Leu 
        195                 200                 205             


Glu Glu Ile Val Lys Asp Lys Ile Ser Lys Leu Glu Lys Lys Asp Arg 
    210                 215                 220                 


Ile Leu Lys Leu Phe Pro Gly Glu Lys Asn Ser Gly Ile Phe Ser Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Arg Lys Cys Phe 
                245                 250                 255     


Asn Leu Asp Glu Lys Ala Ser Leu His Phe Ser Lys Glu Ser Tyr Asp 
            260                 265                 270         


Glu Asp Leu Glu Thr Leu Leu Gly Tyr Ile Gly Asp Asp Tyr Ser Asp 
        275                 280                 285             


Val Phe Leu Lys Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Phe Leu Thr Val Thr Asp Asn Glu Thr Glu Ala Pro Leu Ser Ser Ala 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asn Glu His Lys Glu Asp Leu Ala Leu Leu Lys 
                325                 330                 335     


Glu Tyr Ile Arg Asn Ile Ser Leu Lys Thr Tyr Asn Glu Val Phe Lys 
            340                 345                 350         


Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Asp Phe Tyr Val Tyr Leu Lys Lys Leu Leu Ala Glu Phe Glu 
    370                 375                 380                 


Gly Ala Asp Tyr Phe Leu Glu Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Leu Asp Lys Gln Ala Lys Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Lys Asn Lys Glu Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Asp Phe Ala Trp 
    450                 455                 460                 


Ser Ile Arg Lys Arg Asn Glu Lys Ile Thr Pro Trp Asn Phe Glu Asp 
465                 470                 475                 480 


Val Ile Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Ser Phe Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Asn Val Tyr Asn Glu Leu Thr Lys Val Arg 
        515                 520                 525             


Phe Ile Ala Glu Ser Met Arg Asp Tyr Gln Phe Leu Asp Ser Lys Gln 
    530                 535                 540                 


Lys Lys Asp Ile Val Arg Leu Tyr Phe Lys Asp Lys Arg Lys Val Thr 
545                 550                 555                 560 


Asp Lys Asp Ile Ile Glu Tyr Leu His Ala Ile Tyr Gly Tyr Asp Gly 
                565                 570                 575     


Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ser Ser Leu Ser Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Asn Ile Ile Asn Asp Lys Glu Phe Leu Asp Asp 
        595                 600                 605             


Ser Ser Asn Glu Ala Ile Ile Glu Glu Ile Ile His Thr Leu Thr Ile 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ser Lys Phe Glu Asn 
625                 630                 635                 640 


Ile Phe Asp Lys Ser Val Leu Lys Lys Leu Ser Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asp Glu 
            660                 665                 670         


Lys Ser Gly Asn Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ile Ser 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ala Leu Ser Phe Lys 
    690                 695                 700                 


Lys Lys Ile Gln Lys Ala Gln Ile Ile Gly Asp Glu Asp Lys Gly Asn 
705                 710                 715                 720 


Ile Lys Glu Val Val Lys Ser Leu Pro Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly Gly Arg Lys Pro Glu Ser Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Tyr Thr Asn Gln Gly Lys Ser Asn Ser Gln Gln Arg Leu Lys Arg 
    770                 775                 780                 


Leu Glu Lys Ser Leu Lys Glu Leu Gly Ser Lys Ile Leu Lys Glu Asn 
785                 790                 795                 800 


Ile Pro Ala Lys Leu Ser Lys Ile Asp Asn Asn Ala Leu Gln Asn Asp 
                805                 810                 815     


Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly 
            820                 825                 830         


Asp Asp Leu Asp Ile Asp Arg Leu Ser Asn Tyr Asp Ile Asp His Ile 
        835                 840                 845             


Ile Pro Gln Ala Phe Leu Lys Asp Asn Ser Ile Asp Asn Lys Val Leu 
    850                 855                 860                 


Val Ser Ser Ala Ser Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu 
865                 870                 875                 880 


Glu Val Val Lys Lys Arg Lys Thr Phe Trp Tyr Gln Leu Leu Lys Ser 
                885                 890                 895     


Lys Leu Ile Ser Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 
            900                 905                 910         


Gly Gly Leu Ser Pro Glu Asp Lys Ala Gly Phe Ile Gln Arg Gln Leu 
        915                 920                 925             


Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Arg Leu Leu Asp Glu 
    930                 935                 940                 


Lys Phe Asn Asn Lys Lys Asp Glu Asn Asn Arg Ala Val Arg Thr Val 
945                 950                 955                 960 


Lys Ile Ile Thr Leu Lys Ser Thr Leu Val Ser Gln Phe Arg Lys Asp 
                965                 970                 975     


Phe Glu Leu Tyr Lys Val Arg Glu Ile Asn Asp Phe His His Ala His 
            980                 985                 990         


Asp Ala Tyr Leu Asn Ala Val Val  Ala Ser Ala Leu Leu  Lys Lys Tyr 
        995                 1000                 1005             


Pro Lys  Leu Glu Pro Glu Phe  Val Tyr Gly Asp Tyr  Pro Lys Tyr 
    1010                 1015                 1020             


Asn Ser  Phe Arg Glu Arg Lys  Ser Ala Thr Glu Lys  Val Tyr Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Ile  Phe Lys Lys Ser Ile  Ser Leu Ala 
    1040                 1045                 1050             


Asp Gly  Arg Val Ile Glu Arg  Pro Leu Ile Glu Val  Asn Glu Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ser Val Trp Asn  Lys Glu Ser Asp Leu  Ala Thr Val 
    1070                 1075                 1080             


Arg Arg  Val Leu Ser Tyr Pro  Gln Val Asn Val Val  Lys Lys Val 
    1085                 1090                 1095             


Glu Glu  Gln Asn His Gly Leu  Asp Arg Gly Lys Pro  Lys Gly Leu 
    1100                 1105                 1110             


Phe Asn  Ala Asn Leu Ser Ser  Lys Pro Lys Pro Asn  Ser Asn Glu 
    1115                 1120                 1125             


Asn Leu  Val Gly Ala Lys Glu  Tyr Leu Asp Pro Lys  Lys Tyr Gly 
    1130                 1135                 1140             


Gly Tyr  Ala Gly Ile Ser Asn  Ser Phe Thr Val Leu  Val Lys Gly 
    1145                 1150                 1155             


Thr Ile  Glu Lys Gly Ala Lys  Lys Lys Ile Thr Asn  Val Leu Glu 
    1160                 1165                 1170             


Phe Gln  Gly Ile Ser Ile Leu  Asp Arg Ile Asn Tyr  Arg Lys Asp 
    1175                 1180                 1185             


Lys Leu  Asn Phe Leu Leu Glu  Lys Gly Tyr Lys Asp  Ile Glu Leu 
    1190                 1195                 1200             


Ile Ile  Glu Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Ser Asp Gly 
    1205                 1210                 1215             


Ser Arg  Arg Met Leu Ala Ser  Ile Leu Ser Thr Asn  Asn Lys Arg 
    1220                 1225                 1230             


Gly Glu  Ile His Lys Gly Asn  Gln Ile Phe Leu Ser  Gln Lys Phe 
    1235                 1240                 1245             


Val Lys  Leu Leu Tyr His Ala  Lys Arg Ile Ser Asn  Thr Ile Asn 
    1250                 1255                 1260             


Glu Asn  His Arg Lys Tyr Val  Glu Asn His Lys Lys  Glu Phe Glu 
    1265                 1270                 1275             


Glu Leu  Phe Tyr Tyr Ile Leu  Glu Phe Asn Glu Asn  Tyr Val Gly 
    1280                 1285                 1290             


Ala Lys  Lys Asn Gly Lys Leu  Leu Asn Ser Ala Phe  Gln Ser Trp 
    1295                 1300                 1305             


Gln Asn  His Ser Ile Asp Glu  Leu Cys Ser Ser Phe  Ile Gly Pro 
    1310                 1315                 1320             


Thr Gly  Ser Glu Arg Lys Gly  Leu Phe Glu Leu Thr  Ser Arg Gly 
    1325                 1330                 1335             


Ser Ala  Ala Asp Phe Glu Phe  Leu Gly Val Lys Ile  Pro Arg Tyr 
    1340                 1345                 1350             


Arg Asp  Tyr Thr Pro Ser Ser  Leu Leu Lys Asp Ala  Thr Leu Ile 
    1355                 1360                 1365             


His Gln  Ser Val Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ala 
    1370                 1375                 1380             


Lys Leu  Gly Glu Gly 
    1385             


<210> 591
<211> 1121
<212> PRT
<213> Streptococcus thermophilus

<400> 591
Met Ser Asp Leu Val Leu Gly Leu Asp Ile Gly Ile Gly Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 
            20                  25                  30          


Arg Ile Phe Pro Ala Ala Gln Ala Glu Asn Asn Leu Val Arg Arg Thr 
        35                  40                  45              


Asn Arg Gln Gly Arg Arg Leu Ala Arg Arg Lys Lys His Arg Arg Val 
    50                  55                  60                  


Arg Leu Asn Arg Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 
65                  70                  75                  80  


Lys Ile Ser Ile Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu 
                85                  90                  95      


Thr Asp Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 
            100                 105                 110         


Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 
        115                 120                 125             


Asn Ser Ser Val Gly Asp Tyr Ala Gln Ile Val Lys Glu Asn Ser Lys 
    130                 135                 140                 


Gln Leu Glu Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Tyr Gln 
145                 150                 155                 160 


Thr Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Glu Lys Asp Gly Lys 
                165                 170                 175     


Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr Arg Ser Glu 
            180                 185                 190         


Ala Leu Arg Ile Leu Gln Thr Gln Gln Glu Phe Asn Pro Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Asn Arg Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Tyr Arg Thr Ser Gly Glu Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Asp Glu Phe Arg Ala Ala Lys Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Lys Glu Gln Lys Asn Gln Ile 
    290                 295                 300                 


Ile Asn Tyr Val Lys Asn Glu Lys Ala Met Gly Pro Ala Lys Leu Phe 
305                 310                 315                 320 


Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp Val Ala Asp Ile Lys Gly 
                325                 330                 335     


Tyr Arg Ile Asp Lys Ser Gly Lys Ala Glu Ile His Thr Phe Glu Ala 
            340                 345                 350         


Tyr Arg Lys Met Lys Thr Leu Glu Thr Leu Asp Ile Glu Gln Met Asp 
        355                 360                 365             


Arg Glu Thr Leu Asp Lys Leu Ala Tyr Val Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Gln Glu Ala Leu Glu His Glu Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Phe Ser Gln Lys Gln Val Asp Glu Leu Val Gln Phe Arg Lys Ala Asn 
                405                 410                 415     


Ser Ser Ile Phe Gly Lys Gly Trp His Asn Phe Ser Val Lys Leu Met 
            420                 425                 430         


Met Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr 
        435                 440                 445             


Ile Leu Thr Arg Leu Gly Lys Gln Lys Thr Thr Ser Ser Ser Asn Lys 
    450                 455                 460                 


Thr Lys Tyr Ile Asp Glu Lys Leu Leu Thr Glu Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Val Asn Ala Ala 
                485                 490                 495     


Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile Val Ile Glu Met Ala Arg 
            500                 505                 510         


Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala Ile Gln Lys Ile Gln Lys 
        515                 520                 525             


Ala Asn Lys Asp Glu Lys Asp Ala Ala Met Leu Lys Ala Ala Asn Gln 
    530                 535                 540                 


Tyr Asn Gly Lys Ala Glu Leu Pro His Ser Val Phe His Gly His Lys 
545                 550                 555                 560 


Gln Leu Ala Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Leu Tyr Thr Gly Lys Thr Ile Ser Ile His Asp Leu Ile Asn Asn Ser 
            580                 585                 590         


Asn Gln Phe Glu Val Asp His Ile Leu Pro Leu Ser Ile Thr Phe Asp 
        595                 600                 605             


Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ala Thr Ala Asn Gln Glu 
    610                 615                 620                 


Lys Gly Gln Arg Thr Pro Tyr Gln Ala Leu Asp Ser Met Asp Asp Ala 
625                 630                 635                 640 


Trp Ser Phe Arg Glu Leu Lys Ala Phe Val Arg Glu Ser Lys Thr Leu 
                645                 650                 655     


Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys 
            660                 665                 670         


Phe Asp Val Arg Lys Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ser Arg Val Val Leu Asn Ala Leu Gln Glu His Phe Arg Ala 
    690                 695                 700                 


His Lys Ile Asp Thr Lys Val Ser Val Val Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg Arg His Trp Gly Ile Glu Lys Thr Arg Asp Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Asn 
            740                 745                 750         


Leu Trp Lys Lys Gln Lys Asn Thr Leu Val Ser Tyr Ser Glu Asp Gln 
        755                 760                 765             


Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile Ser Asp Asp Glu Tyr Lys 
    770                 775                 780                 


Glu Ser Val Phe Lys Ala Pro Tyr Gln His Phe Val Asp Thr Leu Lys 
785                 790                 795                 800 


Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln Val Asp Ser 
                805                 810                 815     


Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg Gln 
            820                 825                 830         


Ala Lys Val Gly Lys Asp Lys Ala Asp Glu Thr Tyr Val Leu Gly Lys 
        835                 840                 845             


Ile Lys Asp Ile Tyr Thr Gln Asp Gly Tyr Asp Ala Phe Met Lys Ile 
    850                 855                 860                 


Tyr Lys Lys Asp Lys Ser Lys Phe Leu Met Tyr Arg His Asp Pro Gln 
865                 870                 875                 880 


Thr Phe Glu Lys Val Ile Glu Pro Ile Leu Glu Asn Tyr Pro Asn Lys 
                885                 890                 895     


Gln Ile Asn Glu Lys Gly Lys Glu Val Pro Cys Asn Pro Phe Leu Lys 
            900                 905                 910         


Tyr Lys Glu Glu His Gly Tyr Ile Arg Lys Tyr Ser Lys Lys Gly Asn 
        915                 920                 925             


Gly Pro Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Ser Lys Leu Gly Asn 
    930                 935                 940                 


His Ile Asp Ile Thr Pro Lys Asp Ser Asn Asn Lys Val Val Leu Gln 
945                 950                 955                 960 


Ser Val Ser Pro Trp Arg Ala Asp Val Tyr Phe Asn Lys Thr Thr Gly 
                965                 970                 975     


Lys Tyr Glu Ile Leu Gly Leu Lys Tyr Ala Asp Leu Gln Phe Glu Lys 
            980                 985                 990         


Gly Thr Gly Thr Tyr Lys Ile Ser  Gln Glu Lys Tyr Asn  Asp Ile Lys 
        995                 1000                 1005             


Lys Lys  Glu Gly Val Asp Ser  Asp Ser Glu Phe Lys  Phe Thr Leu 
    1010                 1015                 1020             


Tyr Lys  Asn Asp Leu Leu Leu  Val Lys Asp Thr Glu  Thr Lys Glu 
    1025                 1030                 1035             


Gln Gln  Leu Phe Arg Phe Leu  Ser Arg Thr Met Pro  Lys Gln Lys 
    1040                 1045                 1050             


His Tyr  Val Glu Leu Lys Pro  Tyr Asp Lys Gln Lys  Phe Glu Gly 
    1055                 1060                 1065             


Gly Glu  Ala Leu Ile Lys Val  Leu Gly Asn Val Ala  Asn Ser Gly 
    1070                 1075                 1080             


Gln Cys  Lys Lys Gly Leu Gly  Lys Ser Asn Ile Ser  Ile Tyr Lys 
    1085                 1090                 1095             


Val Arg  Thr Asp Val Leu Gly  Asn Gln His Ile Ile  Lys Asn Glu 
    1100                 1105                 1110             


Gly Asp  Lys Pro Lys Leu Asp  Phe 
    1115                 1120     


<210> 592
<211> 1122
<212> PRT
<213> Streptococcus thermophilus

<400> 592
Met Ser Asp Leu Val Leu Gly Leu Asp Ile Gly Ile Gly Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 
            20                  25                  30          


Arg Ile Phe Pro Ala Ala Gln Ala Glu Asn Asn Leu Val Arg Arg Thr 
        35                  40                  45              


Asn Arg Gln Gly Arg Arg Leu Thr Arg Arg Lys Lys His Arg Ile Val 
    50                  55                  60                  


Arg Leu Asn Arg Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 
65                  70                  75                  80  


Lys Ile Ser Ile Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu 
                85                  90                  95      


Thr Asp Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 
            100                 105                 110         


Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 
        115                 120                 125             


Asn Ser Ser Val Gly Asp Tyr Ala Gln Ile Val Lys Glu Asn Ser Lys 
    130                 135                 140                 


Gln Leu Glu Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Tyr Gln 
145                 150                 155                 160 


Thr Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Glu Lys Asp Gly Lys 
                165                 170                 175     


Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr Arg Ser Glu 
            180                 185                 190         


Ala Leu Arg Ile Leu Gln Thr Gln Gln Glu Phe Asn Ser Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Asn Arg Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Tyr Arg Thr Asn Gly Glu Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Asp Glu Phe Arg Ala Ala Lys Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Lys Glu Gln Lys Asn Gln Ile 
    290                 295                 300                 


Ile Asn Tyr Val Lys Asn Glu Lys Val Met Gly Pro Ala Lys Leu Phe 
305                 310                 315                 320 


Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp Val Ala Asp Ile Lys Gly 
                325                 330                 335     


His Arg Ile Asp Lys Ser Gly Lys Ala Glu Ile His Thr Phe Glu Ala 
            340                 345                 350         


Tyr Arg Lys Met Lys Thr Leu Glu Thr Leu Asp Ile Glu Gln Met Asp 
        355                 360                 365             


Arg Glu Thr Leu Asp Lys Leu Ala Tyr Val Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Gln Glu Ala Leu Glu His Glu Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Phe Ser Gln Lys Gln Val Asp Glu Leu Val Gln Phe Arg Lys Ala Asn 
                405                 410                 415     


Ser Ser Ile Phe Gly Lys Gly Trp His Asn Phe Ser Val Lys Leu Met 
            420                 425                 430         


Met Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr 
        435                 440                 445             


Ile Leu Thr Arg Leu Gly Lys Gln Lys Thr Thr Ser Ser Ser Asn Lys 
    450                 455                 460                 


Thr Lys Tyr Ile Asp Glu Lys Leu Leu Thr Glu Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Val Asn Ala Ala 
                485                 490                 495     


Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile Val Ile Glu Met Ala Arg 
            500                 505                 510         


Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala Ile Gln Lys Ile Gln Lys 
        515                 520                 525             


Ala Asn Lys Asp Glu Lys Asp Ala Ala Met Leu Lys Ala Ala Asn Gln 
    530                 535                 540                 


Tyr Asn Gly Lys Ala Glu Leu Pro His Ser Val Phe His Gly His Lys 
545                 550                 555                 560 


Gln Leu Ala Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Leu Tyr Thr Gly Lys Thr Ile Ser Ile His Asp Leu Ile Asn Asn Pro 
            580                 585                 590         


Asn Gln Phe Glu Val Asp His Ile Leu Pro Leu Ser Ile Thr Phe Asp 
        595                 600                 605             


Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ala Thr Ala Asn Gln Glu 
    610                 615                 620                 


Lys Gly Gln Arg Thr Pro Tyr Gln Ala Leu Asp Ser Met Asp Asp Ala 
625                 630                 635                 640 


Trp Ser Phe Arg Glu Leu Lys Ala Phe Val Arg Glu Ser Lys Thr Leu 
                645                 650                 655     


Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys 
            660                 665                 670         


Phe Asp Val Arg Lys Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ser Arg Val Val Leu Asn Ala Leu Gln Glu His Phe Arg Ala 
    690                 695                 700                 


His Lys Ile Asp Thr Lys Val Ser Val Val Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg Arg His Trp Gly Ile Glu Lys Thr Arg Asp Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Asn 
            740                 745                 750         


Leu Trp Lys Lys Gln Lys Asn Thr Leu Val Ser Tyr Ser Glu Glu Gln 
        755                 760                 765             


Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile Ser Asp Asp Glu Tyr Lys 
    770                 775                 780                 


Glu Ser Val Phe Lys Ala Pro Tyr Gln His Phe Val Asp Thr Leu Lys 
785                 790                 795                 800 


Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln Val Asp Ser 
                805                 810                 815     


Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg Gln 
            820                 825                 830         


Ala Lys Val Gly Lys Asp Lys Lys Asp Glu Thr Tyr Val Leu Gly Lys 
        835                 840                 845             


Ile Lys Asp Ile Tyr Thr Gln Asp Gly Tyr Asp Ala Phe Met Lys Ile 
    850                 855                 860                 


Tyr Lys Lys Asp Lys Ser Lys Phe Leu Met Tyr Arg His Asp Pro Gln 
865                 870                 875                 880 


Thr Phe Glu Lys Val Ile Glu Pro Ile Leu Glu Asn Tyr Pro Asn Lys 
                885                 890                 895     


Glu Met Asn Glu Lys Gly Lys Glu Val Pro Cys Asn Pro Phe Leu Lys 
            900                 905                 910         


Tyr Lys Glu Glu His Gly Tyr Ile Arg Lys Tyr Ser Lys Lys Gly Asn 
        915                 920                 925             


Gly Pro Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Ser Lys Leu Leu Gly 
    930                 935                 940                 


Asn Pro Ile Asp Ile Thr Pro Glu Asn Ser Lys Asn Lys Val Val Leu 
945                 950                 955                 960 


Gln Ser Leu Lys Pro Trp Arg Thr Asp Val Tyr Phe Asn Lys Asn Thr 
                965                 970                 975     


Gly Lys Tyr Glu Ile Leu Gly Leu Lys Tyr Ala Asp Leu Gln Phe Glu 
            980                 985                 990         


Lys Lys Thr Gly Thr Tyr Lys Ile  Ser Gln Glu Lys Tyr  Asn Gly Ile 
        995                 1000                 1005             


Met Lys  Glu Glu Gly Val Asp  Ser Asp Ser Glu Phe  Lys Phe Thr 
    1010                 1015                 1020             


Leu Tyr  Lys Asn Asp Leu Leu  Leu Val Lys Asp Thr  Glu Thr Lys 
    1025                 1030                 1035             


Glu Gln  Gln Leu Phe Arg Phe  Leu Ser Arg Thr Met  Pro Asn Val 
    1040                 1045                 1050             


Lys Tyr  Tyr Val Glu Leu Lys  Pro Tyr Ser Lys Asp  Lys Phe Glu 
    1055                 1060                 1065             


Lys Asn  Glu Ser Leu Ile Glu  Ile Leu Gly Ser Ala  Asp Lys Ser 
    1070                 1075                 1080             


Gly Arg  Cys Ile Lys Gly Leu  Gly Lys Ser Asn Ile  Ser Ile Tyr 
    1085                 1090                 1095             


Lys Val  Arg Thr Asp Val Leu  Gly Asn Gln His Ile  Ile Lys Asn 
    1100                 1105                 1110             


Glu Gly  Asp Lys Pro Lys Leu  Asp Phe 
    1115                 1120         


<210> 593
<211> 1388
<212> PRT
<213> Streptococcus thermophilus

<400> 593
Met Thr Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asn Tyr Lys Val Pro Ser Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Ser Lys Lys Tyr Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Val Leu Leu Phe Asp Ser Gly Ile Thr Ala Glu Gly Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Thr Glu Met Ala Thr Leu Asp Asp Ala 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Pro Asp Asp Lys Arg 
            100                 105                 110         


Asp Ser Lys Tyr Pro Ile Phe Gly Asn Leu Val Glu Glu Lys Ala Tyr 
        115                 120                 125             


His Asp Glu Phe Pro Thr Ile Tyr His Leu Arg Lys Tyr Leu Ala Asp 
    130                 135                 140                 


Ser Thr Lys Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Phe Asn Ser 
                165                 170                 175     


Lys Asn Asn Asp Ile Gln Lys Asn Phe Gln Asp Phe Leu Asp Thr Tyr 
            180                 185                 190         


Asn Ala Ile Phe Glu Ser Asp Leu Ser Leu Glu Asn Ser Lys Gln Leu 
        195                 200                 205             


Glu Glu Ile Val Lys Asp Lys Ile Ser Lys Leu Glu Lys Lys Asp Arg 
    210                 215                 220                 


Ile Leu Lys Leu Phe Pro Gly Glu Lys Asn Ser Gly Ile Phe Ser Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Arg Lys Cys Phe 
                245                 250                 255     


Asn Leu Asp Glu Lys Ala Ser Leu His Phe Ser Lys Glu Ser Tyr Asp 
            260                 265                 270         


Glu Asp Leu Glu Thr Leu Leu Gly Tyr Ile Gly Asp Asp Tyr Ser Asp 
        275                 280                 285             


Val Phe Leu Lys Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Phe Leu Thr Val Thr Asp Asn Glu Thr Glu Ala Pro Leu Ser Ser Ala 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asn Glu His Lys Glu Asp Leu Ala Leu Leu Lys 
                325                 330                 335     


Glu Tyr Ile Arg Asn Ile Ser Leu Lys Thr Tyr Asn Glu Val Phe Lys 
            340                 345                 350         


Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Asp Phe Tyr Val Tyr Leu Lys Asn Leu Leu Ala Glu Phe Glu 
    370                 375                 380                 


Gly Ala Asp Tyr Phe Leu Glu Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Leu Asp Lys Gln Ala Lys Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Lys Asn Lys Glu Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Asp Phe Ala Trp 
    450                 455                 460                 


Ser Ile Arg Lys Arg Asn Glu Lys Ile Thr Pro Trp Asn Phe Glu Asp 
465                 470                 475                 480 


Val Ile Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Ser Phe Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Asn Val Tyr Asn Glu Leu Thr Lys Val Arg 
        515                 520                 525             


Phe Ile Ala Glu Ser Met Arg Asp Tyr Gln Phe Leu Asp Ser Lys Gln 
    530                 535                 540                 


Lys Lys Asp Ile Val Arg Leu Tyr Phe Lys Asp Lys Arg Lys Val Thr 
545                 550                 555                 560 


Asp Lys Asp Ile Ile Glu Tyr Leu His Ala Ile Tyr Gly Tyr Asp Gly 
                565                 570                 575     


Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ser Ser Leu Ser Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Asn Ile Ile Asn Asp Lys Glu Phe Leu Asp Asp 
        595                 600                 605             


Ser Ser Asn Glu Ala Ile Ile Glu Glu Ile Ile His Thr Leu Thr Ile 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ser Lys Phe Glu Asn 
625                 630                 635                 640 


Ile Phe Asp Lys Ser Val Leu Lys Lys Leu Ser Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asp Glu 
            660                 665                 670         


Lys Ser Gly Asn Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ile Ser 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ala Leu Ser Phe Lys 
    690                 695                 700                 


Lys Lys Ile Gln Lys Ala Gln Ile Ile Gly Asp Glu Asp Lys Gly Asn 
705                 710                 715                 720 


Ile Lys Glu Val Val Lys Ser Leu Pro Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly Gly Arg Lys Pro Glu Ser Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Tyr Thr Asn Gln Gly Lys Ser Asn Ser Gln Gln Arg Leu Lys Arg 
    770                 775                 780                 


Leu Glu Lys Ser Leu Lys Glu Leu Gly Ser Lys Ile Leu Lys Glu Asn 
785                 790                 795                 800 


Ile Pro Ala Lys Leu Ser Lys Ile Asp Asn Asn Ala Leu Gln Asn Asp 
                805                 810                 815     


Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly 
            820                 825                 830         


Asp Asp Leu Asp Ile Asp Arg Leu Ser Asn Tyr Asp Ile Asp His Ile 
        835                 840                 845             


Ile Pro Gln Ala Phe Leu Lys Asp Asn Ser Ile Asp Asn Lys Val Leu 
    850                 855                 860                 


Val Ser Ser Ala Ser Asn Arg Gly Lys Ser Asp Asp Phe Pro Ser Leu 
865                 870                 875                 880 


Glu Val Val Lys Lys Arg Lys Thr Phe Trp Tyr Gln Leu Leu Lys Ser 
                885                 890                 895     


Lys Leu Ile Ser Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 
            900                 905                 910         


Gly Gly Leu Leu Pro Glu Asp Lys Ala Gly Phe Ile Gln Arg Gln Leu 
        915                 920                 925             


Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Arg Leu Leu Asp Glu 
    930                 935                 940                 


Lys Phe Asn Asn Lys Lys Asp Glu Asn Asn Arg Ala Val Arg Thr Val 
945                 950                 955                 960 


Lys Ile Ile Thr Leu Lys Ser Thr Leu Val Ser Gln Phe Arg Lys Asp 
                965                 970                 975     


Phe Glu Leu Tyr Lys Val Arg Glu Ile Asn Asp Phe His His Ala His 
            980                 985                 990         


Asp Ala Tyr Leu Asn Ala Val Ile  Ala Ser Ala Leu Leu  Lys Lys Tyr 
        995                 1000                 1005             


Pro Lys  Leu Glu Pro Glu Phe  Val Tyr Gly Asp Tyr  Pro Lys Tyr 
    1010                 1015                 1020             


Asn Ser  Phe Arg Glu Arg Lys  Ser Ala Thr Glu Lys  Val Tyr Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Ile  Phe Lys Lys Ser Ile  Ser Leu Ala 
    1040                 1045                 1050             


Asp Gly  Arg Val Ile Glu Arg  Pro Leu Ile Glu Val  Asn Glu Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ser Val Trp Asn  Lys Glu Ser Asp Leu  Ala Thr Val 
    1070                 1075                 1080             


Arg Arg  Val Leu Ser Tyr Pro  Gln Val Asn Val Val  Lys Lys Val 
    1085                 1090                 1095             


Glu Glu  Gln Asn His Gly Leu  Asp Arg Gly Lys Pro  Lys Gly Leu 
    1100                 1105                 1110             


Phe Asn  Ala Asn Leu Ser Ser  Lys Pro Lys Pro Asn  Ser Asn Glu 
    1115                 1120                 1125             


Asn Leu  Val Gly Ala Lys Glu  Tyr Leu Asp Pro Lys  Lys Tyr Gly 
    1130                 1135                 1140             


Gly Tyr  Ala Gly Ile Ser Asn  Ser Phe Ala Val Leu  Val Lys Gly 
    1145                 1150                 1155             


Thr Ile  Glu Lys Gly Ala Lys  Lys Lys Ile Thr Asn  Val Leu Glu 
    1160                 1165                 1170             


Phe Gln  Gly Ile Ser Ile Leu  Asp Arg Ile Asn Tyr  Arg Lys Asp 
    1175                 1180                 1185             


Lys Leu  Asn Phe Leu Leu Glu  Lys Gly Tyr Lys Asp  Ile Glu Leu 
    1190                 1195                 1200             


Ile Ile  Glu Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Ser Asp Gly 
    1205                 1210                 1215             


Ser Arg  Arg Met Leu Ala Ser  Ile Leu Ser Thr Asn  Asn Lys Arg 
    1220                 1225                 1230             


Gly Glu  Ile His Lys Gly Asn  Gln Ile Phe Leu Ser  Gln Lys Phe 
    1235                 1240                 1245             


Val Lys  Leu Leu Tyr His Ala  Lys Arg Ile Ser Asn  Thr Ile Asn 
    1250                 1255                 1260             


Glu Asn  His Arg Lys Tyr Val  Glu Asn His Lys Lys  Glu Phe Glu 
    1265                 1270                 1275             


Glu Leu  Phe Tyr Tyr Ile Leu  Glu Phe Asn Glu Asn  Tyr Val Gly 
    1280                 1285                 1290             


Ala Lys  Lys Asn Gly Lys Leu  Leu Asn Ser Ala Phe  Gln Ser Trp 
    1295                 1300                 1305             


Gln Asn  His Ser Ile Asp Glu  Leu Cys Ser Ser Phe  Ile Gly Pro 
    1310                 1315                 1320             


Thr Gly  Ser Glu Arg Lys Gly  Leu Phe Glu Leu Thr  Ser Arg Gly 
    1325                 1330                 1335             


Ser Ala  Ala Asp Phe Glu Phe  Leu Gly Val Lys Ile  Pro Arg Tyr 
    1340                 1345                 1350             


Arg Asp  Tyr Thr Pro Ser Ser  Leu Leu Lys Asp Ala  Thr Leu Ile 
    1355                 1360                 1365             


His Gln  Ser Val Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ala 
    1370                 1375                 1380             


Lys Leu  Gly Glu Gly 
    1385             


<210> 594
<211> 1121
<212> PRT
<213> Streptococcus thermophilus

<400> 594
Met Ser Asp Leu Val Leu Gly Leu Asp Ile Gly Ile Gly Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 
            20                  25                  30          


Arg Ile Phe Pro Ala Ala Gln Ala Glu Asn Asn Leu Val Arg Arg Thr 
        35                  40                  45              


Asn Arg Gln Gly Arg Arg Leu Thr Arg Arg Lys Lys His Arg Arg Val 
    50                  55                  60                  


Arg Leu Asn Arg Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 
65                  70                  75                  80  


Lys Ile Ser Ile Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu 
                85                  90                  95      


Thr Asp Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 
            100                 105                 110         


Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 
        115                 120                 125             


Asn Ser Ser Val Gly Asp Tyr Ala Gln Ile Val Lys Glu Asn Ser Lys 
    130                 135                 140                 


Gln Leu Glu Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Tyr Gln 
145                 150                 155                 160 


Thr Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Glu Lys Asp Gly Lys 
                165                 170                 175     


Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr Arg Ser Glu 
            180                 185                 190         


Ala Leu Arg Ile Leu Gln Thr Gln Gln Glu Phe Asn Pro Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Val Asn Arg Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Tyr Arg Thr Asn Gly Glu Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Glu Glu Phe Arg Ala Ala Lys Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Lys Glu Gln Lys Asn Gln Ile 
    290                 295                 300                 


Ile Asn Tyr Val Lys Asn Glu Lys Ala Met Gly Pro Ala Lys Leu Phe 
305                 310                 315                 320 


Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp Val Ala Asp Ile Lys Gly 
                325                 330                 335     


Tyr Arg Ile Asp Lys Ser Gly Lys Ala Glu Ile His Thr Phe Glu Ala 
            340                 345                 350         


Tyr Arg Lys Met Lys Thr Leu Glu Thr Leu Asp Ile Glu Gln Met Asp 
        355                 360                 365             


Arg Glu Thr Leu Asp Lys Leu Ala Tyr Val Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Gln Glu Ala Leu Glu His Glu Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Phe Ser Gln Lys Gln Val Asp Glu Leu Val Gln Phe Arg Lys Ala Asn 
                405                 410                 415     


Ser Ser Ile Phe Gly Lys Gly Trp His Asn Phe Ser Val Lys Leu Met 
            420                 425                 430         


Met Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr 
        435                 440                 445             


Ile Leu Lys Arg Leu Gly Lys Gln Lys Thr Thr Ser Ser Ser Asn Lys 
    450                 455                 460                 


Thr Lys Tyr Ile Asp Glu Lys Leu Leu Thr Glu Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ala Lys Ser Ile Arg Gln Ala Ile Lys Ile Val Asn Ala Ala 
                485                 490                 495     


Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile Val Ile Glu Met Ala Arg 
            500                 505                 510         


Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala Ile Gln Lys Ile Gln Lys 
        515                 520                 525             


Ala Asn Lys Asp Glu Lys Asp Ala Ala Met Leu Lys Ala Ala Asn Gln 
    530                 535                 540                 


Tyr Asn Gly Lys Ala Glu Leu Pro His Ser Val Phe His Gly His Lys 
545                 550                 555                 560 


Gln Leu Ala Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Leu Tyr Thr Gly Lys Thr Ile Ser Ile His Asp Leu Ile Asn Asn Pro 
            580                 585                 590         


Asn Gln Phe Glu Val Asp His Ile Leu Pro Leu Ser Ile Thr Phe Asp 
        595                 600                 605             


Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ala Thr Ala Asn Gln Glu 
    610                 615                 620                 


Lys Gly Gln Arg Thr Pro Tyr Gln Ala Leu Asp Ser Met Asp Asp Ala 
625                 630                 635                 640 


Trp Ser Phe Arg Glu Leu Lys Ala Phe Val Arg Glu Ser Lys Thr Leu 
                645                 650                 655     


Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys 
            660                 665                 670         


Phe Asp Val Arg Lys Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ser Arg Val Val Leu Asn Ala Leu Gln Glu His Phe Arg Ala 
    690                 695                 700                 


His Lys Ile Asp Thr Lys Val Ser Val Val Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg Arg His Trp Gly Ile Glu Lys Thr Arg Asp Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Asn 
            740                 745                 750         


Leu Trp Lys Lys Gln Lys Asn Thr Leu Val Ser Tyr Ser Glu Asp Gln 
        755                 760                 765             


Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile Ser Asp Asp Glu Tyr Lys 
    770                 775                 780                 


Glu Ser Val Phe Lys Ala Pro Tyr Gln His Phe Val Asp Thr Leu Lys 
785                 790                 795                 800 


Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln Val Asp Ser 
                805                 810                 815     


Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg Gln 
            820                 825                 830         


Ala Lys Val Gly Lys Asp Lys Lys Asp Glu Thr Tyr Val Leu Gly Lys 
        835                 840                 845             


Ile Lys Asp Ile Tyr Thr Gln Asp Gly Tyr Asp Ala Phe Met Lys Ile 
    850                 855                 860                 


Tyr Lys Lys Asp Lys Ser Lys Phe Leu Met Tyr Arg His Asp Pro Gln 
865                 870                 875                 880 


Thr Phe Glu Lys Val Ile Glu Pro Ile Leu Glu Asn Tyr Pro Asn Lys 
                885                 890                 895     


Glu Met Asn Glu Lys Gly Lys Glu Val Pro Cys Asn Pro Phe Leu Lys 
            900                 905                 910         


Tyr Lys Glu Glu His Gly Tyr Ile Arg Lys Tyr Ser Lys Lys Gly Asn 
        915                 920                 925             


Asp Pro Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Ser Lys Leu Gly Asn 
    930                 935                 940                 


His Ile Asp Ile Thr Pro Lys Asp Ser Asn Asn Lys Val Val Leu Gln 
945                 950                 955                 960 


Ser Val Ser Pro Trp Arg Ala Asp Val Tyr Phe Asn Lys Thr Thr Gly 
                965                 970                 975     


Lys Tyr Glu Ile Leu Gly Leu Lys Tyr Ala Asp Leu Gln Phe Glu Lys 
            980                 985                 990         


Gly Thr Gly Thr Tyr Lys Ile Ser  Gln Glu Lys Tyr Asn  Asp Ile Lys 
        995                 1000                 1005             


Lys Lys  Glu Gly Val Asp Ser  Asp Ser Glu Phe Lys  Phe Thr Leu 
    1010                 1015                 1020             


Tyr Lys  Asn Asp Leu Leu Leu  Val Lys Asp Thr Glu  Thr Lys Glu 
    1025                 1030                 1035             


Gln Gln  Leu Phe Arg Phe Leu  Ser Arg Thr Met Pro  Lys Gln Lys 
    1040                 1045                 1050             


His Tyr  Val Glu Leu Lys Pro  Tyr Asp Lys Gln Lys  Phe Glu Gly 
    1055                 1060                 1065             


Gly Glu  Ala Leu Ile Lys Val  Leu Gly Asn Val Ala  Asn Ser Gly 
    1070                 1075                 1080             


Gln Cys  Lys Lys Gly Leu Gly  Lys Ser Asn Ile Ser  Ile Tyr Lys 
    1085                 1090                 1095             


Val Arg  Thr Asp Val Leu Gly  Asn Gln His Ile Ile  Lys Asn Glu 
    1100                 1105                 1110             


Gly Asp  Lys Pro Lys Leu Asp  Phe 
    1115                 1120     


<210> 595
<211> 1122
<212> PRT
<213> Streptococcus thermophilus


<220>
<223> Streptococcus thermophilus MTCC 5460

<400> 595
Met Ser Asp Leu Val Leu Gly Leu Asp Ile Gly Ile Gly Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 
            20                  25                  30          


Arg Ile Phe Pro Ala Ala Gln Ala Glu Asn Asn Val Glu Arg Arg Thr 
        35                  40                  45              


Asn Arg Gln Gly Arg Arg Leu Thr Arg Arg Lys Lys His Arg Arg Val 
    50                  55                  60                  


Arg Leu Asn Arg Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 
65                  70                  75                  80  


Lys Ile Ser Ile Asn Leu Asn Pro Tyr Gln Leu Arg Val Arg Gly Leu 
                85                  90                  95      


Thr Asp Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 
            100                 105                 110         


Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 
        115                 120                 125             


Asn Ser Ser Val Gly Asp Tyr Ala Gln Ile Val Lys Glu Asn Ser Lys 
    130                 135                 140                 


Gln Leu Glu Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Tyr Gln 
145                 150                 155                 160 


Thr Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Glu Lys Asp Gly Lys 
                165                 170                 175     


Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr Arg Ser Glu 
            180                 185                 190         


Ala Leu Arg Ile Leu Gln Thr Gln Gln Glu Phe Asn Ser Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Asn Arg Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Tyr Arg Thr Ser Gly Glu Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Glu Glu Phe Arg Ala Ala Lys Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Lys Glu Gln Lys Asn Gln Ile 
    290                 295                 300                 


Ile Asn Tyr Val Lys Asn Glu Lys Ala Met Gly Pro Ala Lys Leu Phe 
305                 310                 315                 320 


Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp Val Ala Asp Ile Lys Gly 
                325                 330                 335     


Tyr Arg Ile Asp Lys Ser Gly Lys Ala Glu Ile His Thr Phe Glu Ala 
            340                 345                 350         


Tyr Arg Lys Met Lys Thr Leu Glu Thr Leu Asp Ile Glu Gln Met Asp 
        355                 360                 365             


Arg Glu Thr Leu Asp Lys Leu Ala Tyr Val Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Gln Glu Ala Leu Glu His Glu Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Phe Ser Gln Lys Gln Val Asp Glu Leu Val Gln Phe Arg Lys Ala Ser 
                405                 410                 415     


Ser Ser Ile Phe Gly Lys Gly Trp His Asn Phe Ser Val Lys Leu Met 
            420                 425                 430         


Met Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr 
        435                 440                 445             


Ile Leu Thr Arg Leu Gly Lys Gln Lys Thr Thr Ser Ser Ser Asn Lys 
    450                 455                 460                 


Thr Lys Tyr Ile Asp Glu Lys Leu Leu Thr Glu Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Val Asn Ala Ala 
                485                 490                 495     


Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile Val Ile Glu Met Ala Arg 
            500                 505                 510         


Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala Ile Gln Lys Ile Gln Lys 
        515                 520                 525             


Ala Asn Lys Asp Glu Lys Asp Ala Ala Met Leu Lys Ala Ala Asn Gln 
    530                 535                 540                 


Tyr Asn Gly Lys Ala Glu Leu Pro His Ser Val Phe His Gly His Lys 
545                 550                 555                 560 


Gln Leu Ala Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Leu Tyr Thr Gly Lys Thr Ile Ser Ile His Asp Leu Ile Asn Asn Pro 
            580                 585                 590         


Asn Gln Phe Glu Val Asp His Ile Leu Pro Leu Ser Ile Thr Phe Asp 
        595                 600                 605             


Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ala Thr Ala Asn Gln Glu 
    610                 615                 620                 


Lys Gly Gln Arg Thr Pro Tyr Gln Ala Leu Asp Ser Met Asp Asp Ala 
625                 630                 635                 640 


Trp Ser Phe Arg Glu Leu Lys Ala Phe Val Arg Glu Ser Lys Thr Leu 
                645                 650                 655     


Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys 
            660                 665                 670         


Phe Asp Val Arg Lys Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ser Arg Val Val Leu Asn Ala Leu Gln Glu His Phe Arg Ala 
    690                 695                 700                 


His Lys Ile Asp Thr Lys Val Ser Val Val Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg Arg His Trp Gly Ile Glu Lys Thr Arg Asp Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Asn 
            740                 745                 750         


Leu Trp Lys Lys Gln Lys Asn Thr Leu Val Ser Tyr Ser Glu Asp Gln 
        755                 760                 765             


Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile Ser Asp Asp Glu Tyr Lys 
    770                 775                 780                 


Glu Ser Val Phe Lys Ala Pro Tyr Gln His Phe Val Asp Thr Leu Lys 
785                 790                 795                 800 


Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln Val Asp Ser 
                805                 810                 815     


Lys Phe Asn Arg Lys Leu Ser Asp Ala Thr Ile Tyr Ala Thr Arg Gln 
            820                 825                 830         


Ala Lys Val Gly Lys Asp Lys Lys Asp Glu Thr Tyr Val Leu Gly Lys 
        835                 840                 845             


Ile Lys Asp Ile Tyr Thr Gln Asp Gly Tyr Asp Ala Phe Met Lys Ile 
    850                 855                 860                 


Tyr Lys Lys Asp Lys Ser Lys Phe Leu Met Tyr Arg His Asp Pro Gln 
865                 870                 875                 880 


Thr Phe Glu Lys Val Ile Glu Pro Ile Leu Glu Asn Tyr Pro Asn Lys 
                885                 890                 895     


Glu Met Asn Glu Lys Gly Lys Glu Val Pro Cys Asn Pro Phe Leu Lys 
            900                 905                 910         


Tyr Lys Glu Glu His Gly Tyr Ile Arg Lys Tyr Ser Lys Lys Gly Asn 
        915                 920                 925             


Gly Pro Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Ser Lys Leu Leu Gly 
    930                 935                 940                 


Asn Pro Ile Asp Ile Thr Pro Glu Asn Ser Lys Asn Lys Val Val Leu 
945                 950                 955                 960 


Gln Ser Leu Lys Pro Trp Arg Ala Asp Val Tyr Phe Asn Lys Thr Thr 
                965                 970                 975     


Gly Lys Tyr Glu Ile Leu Gly Leu Lys Tyr Ala Asp Leu Gln Phe Glu 
            980                 985                 990         


Lys Lys Thr Gly Thr Tyr Lys Ile  Ser Gln Glu Lys Tyr  Asn Gly Ile 
        995                 1000                 1005             


Met Lys  Glu Glu Gly Val Asp  Ser Asp Ser Glu Phe  Lys Phe Thr 
    1010                 1015                 1020             


Leu Tyr  Lys Asn Asp Leu Leu  Leu Val Lys Asp Thr  Glu Thr Lys 
    1025                 1030                 1035             


Glu Gln  Gln Leu Phe Arg Phe  Leu Ser Arg Thr Met  Pro Asn Val 
    1040                 1045                 1050             


Lys Tyr  Tyr Val Glu Leu Lys  Pro Tyr Ser Lys Asp  Lys Phe Glu 
    1055                 1060                 1065             


Lys Asn  Glu Ser Leu Ile Glu  Ile Leu Gly Ser Ala  Asp Lys Ser 
    1070                 1075                 1080             


Gly Arg  Cys Ile Lys Gly Leu  Gly Lys Ser Asn Ile  Ser Ile Tyr 
    1085                 1090                 1095             


Lys Val  Arg Thr Asp Val Leu  Gly Asn Gln His Ile  Ile Lys Asn 
    1100                 1105                 1110             


Glu Gly  Asp Lys Pro Lys Leu  Asp Phe 
    1115                 1120         


<210> 596
<211> 1121
<212> PRT
<213> Streptococcus thermophilus

<400> 596
Met Ser Asp Leu Val Leu Gly Leu Asp Ile Gly Ile Gly Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 
            20                  25                  30          


Arg Ile Phe Pro Ala Ala Gln Ala Glu Asn Asn Leu Val Arg Arg Thr 
        35                  40                  45              


Asn Arg Gln Gly Arg Arg Leu Thr Arg Arg Lys Lys His Arg Ile Val 
    50                  55                  60                  


Arg Leu Asn Arg Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 
65                  70                  75                  80  


Lys Ile Ser Ile Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu 
                85                  90                  95      


Thr Asp Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 
            100                 105                 110         


Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 
        115                 120                 125             


Asn Ser Ser Val Gly Asp Tyr Ala Gln Ile Val Lys Glu Asn Ser Lys 
    130                 135                 140                 


Gln Leu Glu Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Tyr Gln 
145                 150                 155                 160 


Thr Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Glu Lys Asp Gly Lys 
                165                 170                 175     


Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr Arg Ser Glu 
            180                 185                 190         


Ala Leu Arg Ile Leu Gln Thr Gln Gln Glu Phe Asn Pro Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Asn Arg Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Tyr Arg Thr Ser Gly Glu Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Asp Glu Phe Arg Ala Ala Lys Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Lys Glu Gln Lys Asn Gln Ile 
    290                 295                 300                 


Ile Asn Tyr Val Lys Asn Glu Lys Ala Met Gly Pro Ala Lys Leu Phe 
305                 310                 315                 320 


Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp Val Ala Asp Ile Lys Gly 
                325                 330                 335     


Tyr Arg Ile Asp Lys Ser Gly Lys Ala Glu Ile His Thr Phe Glu Ala 
            340                 345                 350         


Tyr Arg Lys Met Lys Thr Leu Glu Thr Leu Asp Ile Glu Gln Met Asp 
        355                 360                 365             


Arg Glu Thr Leu Asp Lys Leu Ala Tyr Val Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Gln Glu Ala Leu Glu His Glu Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Phe Ser Gln Lys Gln Val Asp Glu Leu Val Gln Phe Arg Lys Ala Asn 
                405                 410                 415     


Ser Ser Ile Phe Gly Lys Gly Trp His Asn Phe Ser Val Lys Leu Met 
            420                 425                 430         


Met Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr 
        435                 440                 445             


Ile Leu Thr Arg Leu Gly Lys Gln Lys Thr Thr Ser Ser Ser Asn Lys 
    450                 455                 460                 


Thr Lys Tyr Ile Asp Glu Lys Leu Leu Thr Glu Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Val Asn Ala Ala 
                485                 490                 495     


Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile Val Ile Glu Met Ala Arg 
            500                 505                 510         


Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala Ile Gln Lys Ile Gln Lys 
        515                 520                 525             


Ala Asn Lys Asp Glu Lys Asp Ala Ala Met Leu Lys Ala Ala Asn Gln 
    530                 535                 540                 


Tyr Asn Gly Lys Ala Glu Leu Pro His Ser Val Phe His Gly His Lys 
545                 550                 555                 560 


Gln Leu Ala Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Leu Tyr Thr Gly Lys Thr Ile Ser Ile His Asp Leu Ile Asn Asn Ser 
            580                 585                 590         


Asn Gln Phe Glu Val Asp His Ile Leu Pro Leu Ser Ile Thr Phe Asp 
        595                 600                 605             


Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ala Thr Ala Asn Gln Glu 
    610                 615                 620                 


Lys Gly Gln Arg Thr Pro Tyr Gln Ala Leu Asp Ser Met Asp Asp Ala 
625                 630                 635                 640 


Trp Ser Phe Arg Glu Leu Lys Ala Phe Val Arg Glu Ser Lys Thr Leu 
                645                 650                 655     


Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys 
            660                 665                 670         


Phe Asp Val Arg Lys Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ser Arg Val Val Leu Asn Ala Leu Gln Glu His Phe Arg Ala 
    690                 695                 700                 


His Lys Ile Asp Thr Lys Val Ser Val Val Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg Arg His Trp Gly Ile Glu Lys Thr Arg Asp Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Asn 
            740                 745                 750         


Leu Trp Lys Lys Gln Lys Asn Thr Leu Val Ser Tyr Ser Glu Asp Gln 
        755                 760                 765             


Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile Ser Asp Asp Glu Tyr Lys 
    770                 775                 780                 


Glu Ser Val Phe Lys Ala Pro Tyr Gln His Phe Val Asp Thr Leu Lys 
785                 790                 795                 800 


Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln Val Asp Ser 
                805                 810                 815     


Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg Gln 
            820                 825                 830         


Ala Lys Val Gly Lys Asp Lys Ala Asp Glu Thr Tyr Val Leu Gly Lys 
        835                 840                 845             


Ile Lys Asp Ile Tyr Thr Gln Asp Gly Tyr Asp Ala Phe Met Lys Ile 
    850                 855                 860                 


Tyr Lys Lys Asp Lys Ser Lys Phe Leu Met Tyr Arg His Asp Pro Gln 
865                 870                 875                 880 


Thr Phe Glu Lys Val Ile Glu Pro Ile Leu Glu Asn Tyr Pro Asn Lys 
                885                 890                 895     


Gln Met Asn Glu Lys Gly Lys Glu Val Pro Cys Asn Pro Phe Leu Lys 
            900                 905                 910         


Tyr Lys Glu Glu His Gly Tyr Ile Arg Lys Tyr Ser Lys Lys Gly Asn 
        915                 920                 925             


Gly Pro Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Ser Lys Leu Gly Asn 
    930                 935                 940                 


His Ile Asp Ile Thr Pro Lys Asp Ser Asn Asn Lys Val Val Leu Gln 
945                 950                 955                 960 


Ser Val Ser Pro Trp Arg Ala Asp Ile Tyr Phe Asn Asn Thr Thr Gly 
                965                 970                 975     


Lys Tyr Glu Ile Leu Gly Leu Lys Tyr Ala Asp Leu Gln Phe Glu Lys 
            980                 985                 990         


Gly Thr Gly Thr Tyr Lys Ile Ser  Gln Glu Lys Tyr Asn  Asp Ile Lys 
        995                 1000                 1005             


Lys Lys  Glu Gly Val Asp Ser  Asp Ser Glu Phe Lys  Phe Thr Leu 
    1010                 1015                 1020             


Tyr Lys  Asn Asp Leu Leu Leu  Val Lys Glu Thr Glu  Thr Lys Glu 
    1025                 1030                 1035             


Gln Gln  Leu Phe Arg Phe Leu  Ser Arg Thr Met Pro  Lys Gln Lys 
    1040                 1045                 1050             


His Tyr  Val Glu Leu Lys Pro  Tyr Asp Lys Gln Lys  Phe Glu Gly 
    1055                 1060                 1065             


Gly Glu  Ala Leu Ile Lys Val  Leu Gly Asn Val Ala  Asn Gly Gly 
    1070                 1075                 1080             


Gln Cys  Ile Lys Gly Leu Gly  Lys Ser Asn Ile Ser  Ile Tyr Lys 
    1085                 1090                 1095             


Val Arg  Thr Asp Val Leu Gly  Asn Gln His Ile Ile  Lys Asn Glu 
    1100                 1105                 1110             


Gly Asp  Lys Pro Lys Leu Asp  Phe 
    1115                 1120     


<210> 597
<211> 1388
<212> PRT
<213> Streptococcus thermophilus

<400> 597
Met Thr Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asn Tyr Lys Val Pro Ser Lys Lys Met 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Ser Lys Lys Tyr Ile Lys Lys Asn Leu Leu 
        35                  40                  45              


Gly Val Leu Leu Phe Asp Ser Gly Ile Thr Ala Glu Gly Arg Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Thr Glu Met Ala Thr Leu Asp Asp Ala 
                85                  90                  95      


Phe Phe Gln Arg Leu Asp Asp Ser Phe Leu Val Pro Asp Asp Lys Arg 
            100                 105                 110         


Asp Ser Lys Tyr Pro Ile Phe Gly Asn Leu Val Glu Glu Lys Ala Tyr 
        115                 120                 125             


His Asp Glu Phe Pro Thr Ile Tyr His Leu Arg Lys Tyr Leu Ala Asp 
    130                 135                 140                 


Ser Thr Lys Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Phe Asn Ser 
                165                 170                 175     


Lys Asn Asn Asp Ile Gln Lys Asn Phe Gln Asp Phe Leu Asp Thr Tyr 
            180                 185                 190         


Asn Ala Ile Phe Glu Ser Asp Leu Ser Leu Glu Asn Ser Lys Gln Leu 
        195                 200                 205             


Glu Glu Ile Val Lys Asp Lys Ile Ser Lys Leu Glu Lys Lys Asp Arg 
    210                 215                 220                 


Ile Leu Lys Leu Phe Pro Gly Glu Lys Asn Ser Gly Ile Phe Ser Glu 
225                 230                 235                 240 


Phe Leu Lys Leu Ile Val Gly Asn Gln Ala Asp Phe Arg Lys Cys Phe 
                245                 250                 255     


Asn Leu Asp Glu Lys Ala Ser Leu His Phe Ser Lys Glu Ser Tyr Asp 
            260                 265                 270         


Glu Asp Leu Glu Thr Leu Leu Gly Tyr Ile Gly Asp Asp Tyr Ser Asp 
        275                 280                 285             


Val Phe Leu Lys Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser Gly 
    290                 295                 300                 


Phe Leu Thr Val Thr Asp Asn Glu Thr Glu Ala Pro Leu Ser Ser Ala 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asn Glu His Lys Glu Asp Leu Ala Leu Leu Lys 
                325                 330                 335     


Glu Tyr Ile Arg Asn Ile Ser Leu Lys Thr Tyr Asn Glu Val Phe Lys 
            340                 345                 350         


Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 
        355                 360                 365             


Gln Glu Asp Phe Tyr Val Tyr Leu Lys Asn Leu Leu Ala Glu Phe Glu 
    370                 375                 380                 


Gly Ala Asp Tyr Phe Leu Glu Lys Ile Asp Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gln Ile His Leu 
                405                 410                 415     


Gln Glu Met Arg Ala Ile Leu Asp Lys Gln Ala Lys Phe Tyr Pro Phe 
            420                 425                 430         


Leu Ala Lys Asn Lys Glu Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Asp Phe Ala Trp 
    450                 455                 460                 


Ser Ile Arg Lys Arg Asn Glu Lys Ile Thr Pro Trp Asn Phe Glu Asp 
465                 470                 475                 480 


Val Ile Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 
                485                 490                 495     


Ser Phe Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Thr Phe Asn Val Tyr Asn Glu Leu Thr Lys Val Arg 
        515                 520                 525             


Phe Ile Ala Glu Ser Met Arg Asp Tyr Gln Phe Leu Asp Ser Lys Gln 
    530                 535                 540                 


Lys Lys Asp Ile Val Arg Leu Tyr Phe Lys Asp Lys Arg Lys Val Thr 
545                 550                 555                 560 


Asp Lys Asp Ile Ile Glu Tyr Leu His Ala Ile Tyr Gly Tyr Asp Gly 
                565                 570                 575     


Ile Glu Leu Lys Gly Ile Glu Lys Gln Phe Asn Ser Ser Leu Ser Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Asn Ile Ile Asn Asp Lys Glu Phe Leu Asp Asp 
        595                 600                 605             


Ser Ser Asn Glu Ala Ile Ile Glu Glu Ile Ile His Thr Leu Thr Ile 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Lys Gln Arg Leu Ser Lys Phe Glu Asn 
625                 630                 635                 640 


Ile Phe Asp Lys Ser Val Leu Lys Lys Leu Ser Arg Arg His Tyr Thr 
                645                 650                 655     


Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asp Glu 
            660                 665                 670         


Lys Ser Gly Asn Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ile Ser 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ala Leu Ser Phe Lys 
    690                 695                 700                 


Lys Lys Ile Gln Lys Ala Gln Ile Ile Gly Asp Glu Asp Lys Gly Asn 
705                 710                 715                 720 


Ile Lys Glu Val Val Lys Ser Leu Pro Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met 
            740                 745                 750         


Gly Gly Arg Lys Pro Glu Ser Ile Val Val Glu Met Ala Arg Glu Asn 
        755                 760                 765             


Gln Tyr Thr Asn Gln Gly Lys Ser Asn Ser Gln Gln Arg Leu Lys Arg 
    770                 775                 780                 


Leu Glu Lys Ser Leu Lys Glu Leu Gly Ser Lys Ile Leu Lys Glu Asn 
785                 790                 795                 800 


Ile Pro Ala Lys Leu Ser Lys Ile Asp Asn Asn Ala Leu Gln Asn Asp 
                805                 810                 815     


Arg Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Lys Asp Met Tyr Thr Gly 
            820                 825                 830         


Asp Asp Leu Asp Ile Asp Arg Leu Ser Asn Tyr Asp Ile Asp His Ile 
        835                 840                 845             


Ile Pro Gln Ala Phe Leu Lys Asp Asn Ser Ile Asp Asn Lys Val Leu 
    850                 855                 860                 


Val Ser Ser Ala Ser Asn Arg Gly Lys Ser Asp Asp Phe Pro Ser Leu 
865                 870                 875                 880 


Glu Val Val Lys Lys Arg Lys Thr Phe Trp Tyr Gln Leu Leu Lys Ser 
                885                 890                 895     


Lys Leu Ile Ser Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 
            900                 905                 910         


Gly Gly Leu Leu Pro Glu Asp Lys Ala Gly Phe Ile Gln Arg Gln Leu 
        915                 920                 925             


Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Arg Leu Leu Asp Glu 
    930                 935                 940                 


Lys Phe Asn Asn Lys Lys Asp Glu Asn Asn Arg Ala Val Arg Thr Val 
945                 950                 955                 960 


Lys Ile Ile Thr Leu Lys Ser Thr Leu Val Ser Gln Phe Arg Lys Asp 
                965                 970                 975     


Phe Glu Leu Tyr Lys Val Cys Glu Ile Asn Asp Phe His His Ala His 
            980                 985                 990         


Asp Ala Tyr Leu Asn Ala Val Ile  Ala Ser Ala Leu Leu  Lys Lys Tyr 
        995                 1000                 1005             


Pro Lys  Leu Glu Pro Glu Phe  Val Tyr Gly Asp Tyr  Pro Lys Tyr 
    1010                 1015                 1020             


Asn Ser  Phe Arg Glu Arg Lys  Ser Ala Thr Glu Lys  Val Tyr Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Ile  Phe Lys Lys Ser Ile  Ser Leu Ala 
    1040                 1045                 1050             


Asp Gly  Arg Val Ile Glu Arg  Pro Leu Ile Glu Val  Asn Glu Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ser Val Trp Asn  Lys Glu Ser Asp Leu  Ala Thr Val 
    1070                 1075                 1080             


Arg Arg  Val Leu Ser Tyr Pro  Gln Val Asn Val Val  Lys Lys Val 
    1085                 1090                 1095             


Glu Glu  Gln Asn His Gly Leu  Asp Arg Gly Lys Pro  Lys Gly Leu 
    1100                 1105                 1110             


Phe Asn  Ala Asn Leu Ser Ser  Lys Pro Lys Pro Asn  Ser Asn Glu 
    1115                 1120                 1125             


Asn Leu  Val Gly Ala Lys Glu  Tyr Leu Asp Pro Lys  Lys Tyr Gly 
    1130                 1135                 1140             


Gly Tyr  Ala Gly Ile Ser Asn  Ser Phe Ala Val Leu  Val Lys Gly 
    1145                 1150                 1155             


Thr Ile  Glu Lys Gly Ala Lys  Lys Lys Ile Thr Asn  Val Leu Glu 
    1160                 1165                 1170             


Phe Gln  Gly Ile Ser Ile Leu  Asp Arg Ile Asn Tyr  Arg Lys Asp 
    1175                 1180                 1185             


Lys Leu  Asn Phe Leu Leu Glu  Lys Gly Tyr Lys Asp  Ile Glu Leu 
    1190                 1195                 1200             


Ile Ile  Glu Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Ser Asp Gly 
    1205                 1210                 1215             


Ser Arg  Arg Met Leu Ala Ser  Ile Leu Ser Thr Asn  Asn Lys Arg 
    1220                 1225                 1230             


Gly Glu  Ile His Lys Gly Asn  Gln Ile Phe Leu Ser  Gln Lys Phe 
    1235                 1240                 1245             


Val Lys  Leu Leu Tyr His Ala  Lys Arg Ile Ser Asn  Thr Ile Asn 
    1250                 1255                 1260             


Glu Asn  His Arg Lys Tyr Val  Glu Asn His Lys Lys  Glu Phe Glu 
    1265                 1270                 1275             


Glu Leu  Phe Tyr Tyr Ile Leu  Glu Phe Asn Glu Asn  Tyr Val Gly 
    1280                 1285                 1290             


Ala Lys  Lys Asn Gly Lys Leu  Leu Asn Ser Ala Phe  Gln Ser Trp 
    1295                 1300                 1305             


Gln Asn  His Ser Ile Asp Glu  Leu Cys Ser Ser Phe  Ile Gly Pro 
    1310                 1315                 1320             


Thr Gly  Ser Glu Arg Lys Gly  Leu Phe Glu Leu Thr  Ser Arg Gly 
    1325                 1330                 1335             


Ser Ala  Ala Asp Phe Glu Phe  Leu Gly Val Lys Ile  Pro Arg Tyr 
    1340                 1345                 1350             


Arg Asp  Tyr Thr Pro Ser Ser  Leu Leu Lys Asp Ala  Thr Leu Ile 
    1355                 1360                 1365             


His Gln  Ser Val Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ala 
    1370                 1375                 1380             


Lys Leu  Gly Glu Gly 
    1385             


<210> 598
<211> 1128
<212> PRT
<213> Streptococcus vestibularis


<220>
<223> Streptococcus vestibularis ATCC 49124

<400> 598
Met Ser Asp Leu Val Leu Gly Leu Asp Ile Gly Ile Gly Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 
            20                  25                  30          


Arg Ile Phe Pro Ala Ala Gln Ala Glu Asn Asn Val Glu Arg Arg Thr 
        35                  40                  45              


Asn Arg Gln Gly Arg Arg Leu Thr Arg Arg Lys Lys His Arg Arg Val 
    50                  55                  60                  


Arg Leu Asn His Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 
65                  70                  75                  80  


Lys Val Ser Ile Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu 
                85                  90                  95      


Ile Asp Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 
            100                 105                 110         


Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 
        115                 120                 125             


Asn Ser Ser Val Gly Asp Tyr Ala Gln Ile Val Lys Glu Asn Ser Lys 
    130                 135                 140                 


Gln Leu Glu Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Tyr Gln 
145                 150                 155                 160 


Lys Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Glu Glu Asp Gly Lys 
                165                 170                 175     


Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr Arg Ser Glu 
            180                 185                 190         


Ala Leu Arg Ile Leu Gln Thr Gln Lys Glu Phe Asn Pro Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Asn Arg Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Tyr Thr Thr Lys Lys Asp Ser Glu Asn Glu Tyr Ile Thr Leu Asp Asn 
                245                 250                 255     


Ile Phe Gly Ile Leu Ile Gly Lys Cys Thr Phe Tyr Pro Glu Glu Tyr 
            260                 265                 270         


Arg Ala Ala Lys Ala Ser Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn 
        275                 280                 285             


Asp Leu Asn Asn Leu Thr Val Pro Thr Glu Thr Lys Lys Leu Ser Glu 
    290                 295                 300                 


Glu Gln Lys Asn Gln Ile Ile Asn Tyr Val Lys Asn Glu Lys Ala Met 
305                 310                 315                 320 


Gly Pro Ala Lys Leu Phe Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp 
                325                 330                 335     


Val Ala Asp Ile Lys Gly Tyr Arg Ile Asp Lys Ser Asp Lys Ala Glu 
            340                 345                 350         


Ile His Thr Phe Glu Ala Tyr Arg Lys Met Lys Thr Leu Glu Thr Ile 
        355                 360                 365             


Asp Phe Glu Lys Met Ser Arg Asp Gln Leu Asp Lys Leu Ala Tyr Val 
    370                 375                 380                 


Leu Thr Leu Asn Thr Glu Arg Glu Gly Ile Gln Glu Ala Leu Asp His 
385                 390                 395                 400 


Glu Phe Ala Asp Gly Asn Phe Ser Gln Glu Gln Ile Asp Glu Leu Val 
                405                 410                 415     


Gln Phe Arg Lys Ala Asn Ser Ser Ile Phe Gly Lys Gly Trp His Asn 
            420                 425                 430         


Phe Ser Val Lys Leu Met Met Glu Leu Ile Pro Glu Leu Tyr Ala Thr 
        435                 440                 445             


Ser Glu Glu Gln Met Thr Ile Leu Thr Arg Leu Gly Lys Gln Lys Thr 
    450                 455                 460                 


Thr Ser Ser Ser Asn Lys Thr Lys Tyr Ile Asp Glu Lys Leu Leu Thr 
465                 470                 475                 480 


Glu Glu Ile Tyr Asn Pro Val Val Ala Lys Ser Val Arg Gln Ala Ile 
                485                 490                 495     


Lys Ile Val Asn Ala Ala Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile 
            500                 505                 510         


Val Ile Glu Met Ala Arg Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala 
        515                 520                 525             


Ile Gln Lys Ile Gln Lys Ala Asn Lys Asp Glu Lys Asp Ala Ala Met 
    530                 535                 540                 


Leu Lys Ala Ala Asn Gln Tyr Asn Gly Arg Ala Glu Leu Pro His Ser 
545                 550                 555                 560 


Val Phe His Gly His Lys Gln Leu Ala Thr Lys Ile Arg Leu Trp His 
                565                 570                 575     


Gln Gln Gly Glu Arg Cys Leu Tyr Thr Gly Lys Thr Ile Ser Ile His 
            580                 585                 590         


Asp Leu Ile Asn Asn Pro Asn Gln Phe Glu Ile Asp His Ile Leu Pro 
        595                 600                 605             


Leu Ser Ile Thr Phe Asp Asp Ser Leu Ala Asn Lys Val Leu Val Tyr 
    610                 615                 620                 


Ala Thr Ala Asn Gln Glu Lys Gly Gln Arg Thr Pro Tyr Gln Ala Leu 
625                 630                 635                 640 


Asp Ser Met Asp Asp Ala Trp Ser Phe Arg Glu Leu Lys Ala Phe Val 
                645                 650                 655     


Arg Glu Ser Lys Ser Leu Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr 
            660                 665                 670         


Glu Glu Asp Ile Ser Arg Phe Asp Val Arg Lys Lys Phe Ile Glu Arg 
        675                 680                 685             


Asn Leu Val Asp Thr Arg Tyr Ala Ser Arg Val Val Leu Asn Ala Leu 
    690                 695                 700                 


Gln Glu His Phe Arg Ala His Lys Thr Asp Thr Lys Val Ser Val Val 
705                 710                 715                 720 


Arg Gly Gln Phe Thr Ser Gln Leu Arg Arg His Trp Gly Ile Glu Lys 
                725                 730                 735     


Thr Arg Asp Thr Tyr His His His Ala Val Asp Ala Leu Ile Ile Ala 
            740                 745                 750         


Ala Ser Ser Gln Leu Asn Leu Trp Lys Lys Gln Lys Asn Thr Leu Val 
        755                 760                 765             


Asn Tyr Ser Glu Asn Gln Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile 
    770                 775                 780                 


Ser Asp Asp Glu Tyr Lys Glu Ser Val Phe Lys Ala Pro Tyr Gln His 
785                 790                 795                 800 


Phe Val Asp Thr Leu Lys Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe 
                805                 810                 815     


Ser Tyr Gln Val Asp Ser Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr 
            820                 825                 830         


Ile Tyr Ala Thr Arg Gln Ala Lys Val Gly Lys Asp Lys Lys Asp Glu 
        835                 840                 845             


Thr Tyr Val Leu Gly Lys Ile Lys Asp Ile Tyr Ser Gln Thr Gly Tyr 
    850                 855                 860                 


Asp Ala Phe Ile Lys Ile Tyr Gln Lys Asp Lys Ser Lys Phe Leu Met 
865                 870                 875                 880 


Tyr Arg His Asp Pro Gln Thr Phe Glu Lys Val Ile Glu Pro Ile Leu 
                885                 890                 895     


Glu Asn Tyr Pro Asn Lys Glu Met Asn Glu Lys Gly Lys Glu Val Pro 
            900                 905                 910         


Cys Asn Pro Phe Leu Lys Tyr Lys Glu Glu His Gly Asp Tyr Ile Arg 
        915                 920                 925             


Lys Tyr Ser Lys Lys Gly Asn Gly Pro Glu Ile Lys Ser Leu Lys Tyr 
    930                 935                 940                 


Tyr Asp Ser Lys Leu Gly Asn His Ile Asp Ile Thr Pro Lys Asp Ser 
945                 950                 955                 960 


Asn Asn Lys Val Val Leu Gln Ser Val Ser Pro Trp Arg Ala Asp Val 
                965                 970                 975     


Tyr Phe Asn Lys Thr Thr Gly Lys Tyr Glu Ile Leu Gly Leu Lys Tyr 
            980                 985                 990         


Ala Asp Leu Gln Phe Glu Lys Gly  Thr Gly Thr Tyr Lys  Ile Ser Gln 
        995                 1000                 1005             


Glu Lys  Tyr Asn Val Ile Lys  Lys Lys Glu Gly Val  Asp Ser Asp 
    1010                 1015                 1020             


Ser Glu  Phe Lys Phe Thr Leu  Tyr Lys Asn Asp Leu  Leu Leu Ile 
    1025                 1030                 1035             


Lys Asp  Thr Glu Thr Lys Glu  Gln Gln Leu Phe Arg  Phe Leu Ser 
    1040                 1045                 1050             


Arg Thr  Lys Pro Asn Val Lys  His Tyr Val Glu Leu  Lys Pro Tyr 
    1055                 1060                 1065             


Asp Lys  Gln Lys Phe Glu Gly  Asn Glu Ser Leu Ile  Asn Val Leu 
    1070                 1075                 1080             


Gly Ala  Val Ala Lys Gly Gly  Gln Cys Gln Lys Gly  Ile Asn Lys 
    1085                 1090                 1095             


Pro Asn  Ile Ser Ile Tyr Lys  Val Arg Thr Asp Val  Leu Gly Asn 
    1100                 1105                 1110             


Gln His  Ile Ile Lys Asn Glu  Gly Asp Lys Pro Lys  Leu Asp Phe 
    1115                 1120                 1125             


<210> 599
<211> 1084
<212> PRT
<213> Subdoligranulum sp.


<220>
<223> Subdoligranulum sp. 4_3_54A2FAA

<400> 599
Met Lys Asn Thr Leu Tyr Gly Ile Gly Leu Asp Ile Gly Val Ala Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Val Gly Leu Asn Gly Thr Gly Glu Pro Val Gly 
            20                  25                  30          


Leu His Arg Leu Gly Val Arg Ile Phe Asp Lys Ala Glu Gln Pro Lys 
        35                  40                  45              


Thr Gly Glu Ser Leu Ala Ala Pro Arg Arg Met Ala Arg Gly Met Arg 
    50                  55                  60                  


Arg Arg Leu Arg Arg Lys Ala Leu Arg Arg Ala Asp Val Tyr Ala Leu 
65                  70                  75                  80  


Leu Glu Arg Ser Gly Leu Ser Thr Arg Glu Glu Leu Ala Gln Met Phe 
                85                  90                  95      


Glu Ala Gly Gly Leu Glu Asp Ile Tyr Ala Leu Arg Thr Arg Ala Leu 
            100                 105                 110         


Asp Glu Pro Val Gly Lys Ala Glu Phe Ser Arg Ile Leu Leu His Leu 
        115                 120                 125             


Ala Gln Arg Arg Gly Phe Lys Ser Asn Arg Arg Thr Ala Ser Asp Gly 
    130                 135                 140                 


Glu Asp Gly Arg Leu Leu Ala Ala Val Asn Glu Asn Arg Arg Arg Met 
145                 150                 155                 160 


Ala Gln Gly Gly Trp Arg Thr Val Gly Glu Met Leu Tyr Arg His Glu 
                165                 170                 175     


Ala Phe Ala Leu His Lys Arg Asn Lys Ala Asp Asp Tyr Leu Ser Thr 
            180                 185                 190         


Val Gly Arg Asp Met Val Ala Glu Glu Ala Ser Ile Leu Phe Glu Arg 
        195                 200                 205             


Gln Arg Ala Met Gly Cys Ser Trp Ala Ala Pro Glu Leu Gln Ala Glu 
    210                 215                 220                 


Tyr Leu Ser Ile Leu Leu Arg Gln Arg Ser Phe Asp Glu Gly Pro Gly 
225                 230                 235                 240 


Gly Asn Ser Pro Tyr Gly Gly Asn Gln Val Glu Lys Met Val Gly Arg 
                245                 250                 255     


Cys Thr Phe Glu Pro Asp Glu Pro Arg Ala Ala Lys Ala Ala Tyr Ser 
            260                 265                 270         


Phe Glu Tyr Phe Ser Leu Leu Gln Lys Leu Asn His Ile Arg Leu Ala 
        275                 280                 285             


Glu Asn Gly Glu Thr Arg Pro Leu Thr Gln Pro Gln Arg Gln Gln Leu 
    290                 295                 300                 


Leu Ser Leu Ala His Lys Thr Pro Asp Ile Ser Leu Ala Arg Ile Arg 
305                 310                 315                 320 


Lys Glu Leu Ala Leu Pro Glu Thr Val Gln Phe Asn Gly Val Arg Cys 
                325                 330                 335     


Arg Ala Asn Glu Thr Leu Glu Glu Ser Glu Lys Lys Glu Lys Phe Ala 
            340                 345                 350         


Cys Leu Pro Ala Tyr His Lys Met Arg Lys Ala Leu Asp Gly Val Val 
        355                 360                 365             


Lys Gly Arg Ile Ser Ser Leu Ser Ile Ser Gln Arg Asp Ala Ala Ala 
    370                 375                 380                 


Thr Ala Leu Ser Leu Tyr Lys Asn Glu Asp Thr Leu Arg Ala Lys Leu 
385                 390                 395                 400 


Thr Glu Ala Gly Phe Gln Ala Pro Glu Ile Asp Ala Leu Ala Gly Leu 
                405                 410                 415     


Thr Gly Phe Ser Lys Phe Gly His Leu Ser Leu Lys Ala Cys Arg Lys 
            420                 425                 430         


Leu Ile Pro His Leu Glu Gln Gly Leu Thr Tyr Asp Gln Ala Cys Thr 
        435                 440                 445             


Ala Ala Gly Tyr Asp Phe Lys Gly His Gly Ala Gly Glu Arg Ala Phe 
    450                 455                 460                 


Thr Leu Pro Ala Ala Ala Pro Glu Met Glu Gln Ile Thr Ser Pro Val 
465                 470                 475                 480 


Val Arg Arg Ala Val Ala Gln Thr Ile Lys Val Val Asn Gly Ile Ile 
                485                 490                 495     


Arg Glu Met Asp Ala Ser Pro Ala Trp Val Arg Ile Glu Leu Ala Arg 
            500                 505                 510         


Glu Leu Ser Lys Thr Phe Gly Glu Arg Gln Glu Met Asp Arg Ser Met 
        515                 520                 525             


Arg Glu Asn Ala Ala Gln Asn Glu Arg Leu Met Gln Glu Leu Arg Asp 
    530                 535                 540                 


Thr Phe His Leu Leu Ser Pro Thr Gly Gln Asp Leu Val Lys Tyr Arg 
545                 550                 555                 560 


Leu Trp Lys Glu Gln Asp Gly Val Cys Ala Tyr Ser Leu Arg Arg Leu 
                565                 570                 575     


Asp Val Glu Arg Leu Phe Glu Pro Gly Tyr Val Asp Val Asp His Ile 
            580                 585                 590         


Val Pro Tyr Ser Leu Ser Phe Asp Asp Arg Arg Ser Asn Lys Val Leu 
        595                 600                 605             


Val Leu Ser Ser Glu Asn Arg Gln Lys Gly Asn Arg Leu Pro Leu Gln 
    610                 615                 620                 


Tyr Leu Gln Gly Lys Arg Arg Glu Asp Phe Ile Val Trp Thr Asn Ser 
625                 630                 635                 640 


Ser Val His Asp Tyr Arg Lys Arg Gln Asn Leu Leu Arg Glu Lys Leu 
                645                 650                 655     


Ser Gly Asp Glu Ala Glu Gly Phe Arg Gln Arg Asn Leu Gln Asp Thr 
            660                 665                 670         


Gln His Met Ala Arg Phe Leu Tyr Asn Tyr Ile Ser Asp His Leu Ala 
        675                 680                 685             


Phe Ala Gln Ser Glu Ala Leu Gly Lys Lys Arg Val Phe Ala Val Ser 
    690                 695                 700                 


Gly Ala Val Thr Ser His Leu Arg Lys Arg Trp Gly Leu Ser Lys Val 
705                 710                 715                 720 


Arg Ala Asp Gly Asp Leu His His Ala Leu Asp Ala Ala Val Val Ala 
                725                 730                 735     


Cys Thr Thr Asp Gly Met Ile Arg Arg Ile Ser Gly Tyr Tyr Gly His 
            740                 745                 750         


Ile Glu Gly Glu Tyr Leu Gln Asp Ala Asp Gly Ala Gly Ser Gln His 
        755                 760                 765             


Ala Arg Thr Lys Glu Arg Phe Pro Ala Pro Trp Pro Arg Phe Arg Asp 
    770                 775                 780                 


Glu Leu Ile Val Arg Leu Ser Glu Gln Pro Ala Glu Pro Leu Leu Asp 
785                 790                 795                 800 


Ile Asn Pro Glu Phe Tyr Cys Glu Tyr Gly Thr Glu His Ile Arg Pro 
                805                 810                 815     


Val Phe Val Ser Arg Met Pro Arg Arg Lys Val Thr Gly Pro Gly His 
            820                 825                 830         


Lys Glu Thr Ile Lys Gly Ala Ala Ala Ala Asp Glu Gly Leu Leu Thr 
        835                 840                 845             


Val Arg Lys Ala Leu Thr Glu Leu Lys Leu Asp Lys Asp Gly Glu Ile 
    850                 855                 860                 


Lys Asp Tyr Tyr Met Pro Ser Ser Asp Thr Leu Leu Tyr Glu Ala Leu 
865                 870                 875                 880 


Lys Ala Gln Leu Arg Arg Phe Gly Gly Asp Gly Lys Lys Ala Phe Ala 
                885                 890                 895     


Glu Pro Phe Tyr Lys Pro Lys Ala Asp Gly Thr Pro Gly Pro Leu Val 
            900                 905                 910         


Arg Lys Val Lys Thr Thr Glu Lys Ala Thr Leu Thr Val Pro Val His 
        915                 920                 925             


Gly Gly Ala Ala Ser Asn Asp Thr Met Val Arg Val Asp Val Phe Leu 
    930                 935                 940                 


Val Pro Gly Asp Gly Tyr Tyr Trp Val Pro Val Tyr Thr Ala Asp Thr 
945                 950                 955                 960 


Leu Lys Pro Glu Leu Pro Asn Arg Ala Val Val Gln Gly Lys Pro Tyr 
                965                 970                 975     


Ser Glu Trp Lys Glu Met Arg Glu Glu Asp Phe Ile Phe Ser Leu Tyr 
            980                 985                 990         


Pro Asn Asp Leu Val Tyr Val Glu  His Lys Ser Gly Leu  Lys Phe Thr 
        995                 1000                 1005             


Leu Gln  Asn Ala Asp Ser Thr  Leu Glu Lys Thr Arg  Thr Gln Thr 
    1010                 1015                 1020             


Ser Ala  Phe Ala Tyr Phe Val  Ser Gly Ser Ile Ser  Thr Ala Ser 
    1025                 1030                 1035             


Ile Thr  Ile Arg Thr His Asp  Asn Ala Tyr Gly Ile  Pro Ser Leu 
    1040                 1045                 1050             


Gly Val  Lys Thr Leu Lys Thr  Phe His Lys Tyr Gln  Val Asp Val 
    1055                 1060                 1065             


Leu Gly  Asn Val Phe Pro Val  His Lys Glu Thr Arg  Gln Lys Phe 
    1070                 1075                 1080             


Arg 
    


<210> 600
<211> 1422
<212> PRT
<213> Sutterella wadsworthensis


<220>
<223> Sutterella wadsworthensis 3_1_45B

<400> 600
Met Thr Gln Ser Glu Arg Arg Phe Ser Cys Ser Ile Gly Ile Asp Met 
1               5                   10                  15      


Gly Ala Lys Tyr Thr Gly Val Phe Tyr Ala Leu Phe Asp Arg Glu Glu 
            20                  25                  30          


Leu Pro Thr Asn Leu Asn Ser Lys Ala Met Thr Leu Val Met Pro Glu 
        35                  40                  45              


Thr Gly Pro Arg Tyr Val Gln Ala Gln Arg Thr Ala Val Arg His Arg 
    50                  55                  60                  


Leu Arg Gly Gln Lys Arg Tyr Thr Leu Ala Arg Lys Leu Ala Phe Leu 
65                  70                  75                  80  


Val Val Asp Asp Met Ile Lys Lys Gln Glu Lys Arg Leu Thr Asp Glu 
                85                  90                  95      


Glu Trp Lys Arg Gly Arg Glu Ala Leu Ser Gly Leu Leu Lys Arg Arg 
            100                 105                 110         


Gly Tyr Ser Arg Pro Asn Ala Asp Gly Glu Asp Leu Thr Pro Leu Glu 
        115                 120                 125             


Asn Val Arg Ala Asp Val Phe Ala Ala His Pro Ala Phe Ser Thr Tyr 
    130                 135                 140                 


Phe Ser Glu Val Arg Ser Leu Ala Glu Gln Trp Glu Glu Phe Thr Ala 
145                 150                 155                 160 


Asn Ile Ser Asn Val Glu Lys Phe Leu Gly Asp Pro Asn Ile Pro Ala 
                165                 170                 175     


Asp Lys Glu Phe Ile Glu Phe Ala Val Ala Glu Gly Leu Ile Asp Lys 
            180                 185                 190         


Thr Glu Lys Lys Ala Tyr Gln Ser Ala Leu Ser Thr Leu Arg Ala Asn 
        195                 200                 205             


Ala Asn Val Leu Thr Gly Leu Arg Gln Met Gly His Lys Pro Arg Ser 
    210                 215                 220                 


Glu Tyr Phe Lys Ala Ile Glu Ala Asp Leu Lys Lys Asp Ser Arg Leu 
225                 230                 235                 240 


Ala Lys Ile Asn Glu Ala Phe Gly Gly Ala Glu Arg Leu Ala Arg Leu 
                245                 250                 255     


Leu Gly Asn Leu Ser Asn Leu Gln Leu Arg Ala Glu Arg Trp Tyr Phe 
            260                 265                 270         


Asn Ala Pro Asp Ile Met Lys Asp Arg Gly Trp Glu Pro Asp Arg Phe 
        275                 280                 285             


Lys Lys Thr Leu Val Arg Ala Phe Lys Phe Phe His Pro Ala Lys Asp 
    290                 295                 300                 


Gln Asn Lys Gln His Leu Glu Leu Ile Lys Gln Ile Glu Asn Ser Glu 
305                 310                 315                 320 


Asp Ile Ile Glu Thr Leu Cys Thr Leu Asp Pro Asn Arg Thr Ile Pro 
                325                 330                 335     


Pro Tyr Glu Asp Gln Asn Asn Arg Arg Pro Pro Leu Asp Gln Thr Leu 
            340                 345                 350         


Leu Leu Ser Pro Glu Lys Leu Thr Arg Gln Tyr Gly Glu Ile Trp Lys 
        355                 360                 365             


Thr Trp Ser Ala Arg Leu Thr Ser Ala Glu Pro Thr Leu Ala Pro Ala 
    370                 375                 380                 


Ala Glu Ile Leu Glu Arg Ser Thr Asp Arg Lys Ser Arg Val Ala Val 
385                 390                 395                 400 


Asn Gly His Glu Pro Leu Pro Thr Leu Ala Tyr Gln Leu Ser Tyr Ala 
                405                 410                 415     


Leu Gln Arg Ala Phe Asp Arg Ser Lys Ala Leu Asp Pro Tyr Ala Leu 
            420                 425                 430         


Arg Ala Leu Ala Ala Gly Ser Lys Ser Asn Lys Leu Thr Ser Ala Arg 
        435                 440                 445             


Thr Ala Leu Glu Asn Cys Ile Gly Gly Gln Asn Val Lys Thr Phe Leu 
    450                 455                 460                 


Asp Cys Ala Arg Arg Tyr Tyr Arg Glu Ala Asp Asp Ala Lys Val Gly 
465                 470                 475                 480 


Leu Trp Phe Asp Asn Ala Asp Gly Leu Leu Glu Arg Ser Asp Leu His 
                485                 490                 495     


Pro Pro Met Lys Lys Lys Ile Leu Pro Leu Leu Val Ala Asn Ile Leu 
            500                 505                 510         


Gln Thr Asp Glu Thr Thr Gly Gln Lys Phe Leu Asp Glu Ile Trp Arg 
        515                 520                 525             


Lys Gln Ile Lys Gly Arg Glu Thr Val Ala Ser Arg Cys Ala Arg Ile 
    530                 535                 540                 


Glu Thr Val Arg Lys Ser Phe Gly Gly Gly Phe Asn Ile Ala Tyr Asn 
545                 550                 555                 560 


Thr Ala Gln Tyr Arg Glu Val Asn Lys Leu Pro Arg Asn Ala Gln Asp 
                565                 570                 575     


Lys Glu Leu Leu Thr Ile Arg Asp Arg Val Ala Glu Thr Ala Asp Phe 
            580                 585                 590         


Ile Ala Ala Asn Leu Gly Leu Ser Asp Glu Gln Lys Arg Lys Phe Ala 
        595                 600                 605             


Asn Pro Phe Ser Leu Ala Gln Phe Tyr Thr Leu Ile Glu Thr Glu Val 
    610                 615                 620                 


Ser Gly Phe Ser Ala Thr Thr Leu Ala Val His Leu Glu Asn Ala Trp 
625                 630                 635                 640 


Arg Met Thr Ile Lys Asp Ala Val Ile Asn Gly Glu Thr Val Arg Ala 
                645                 650                 655     


Ala Gln Cys Ser Arg Leu Pro Ala Glu Thr Ala Arg Pro Phe Asp Gly 
            660                 665                 670         


Leu Val Arg Arg Leu Val Asp Arg Gln Ala Trp Glu Ile Ala Lys Arg 
        675                 680                 685             


Val Ser Thr Asp Ile Gln Ser Lys Val Asp Phe Ser Asn Gly Ile Val 
    690                 695                 700                 


Asp Val Ser Ile Phe Val Glu Glu Asn Lys Phe Glu Phe Ser Ala Ser 
705                 710                 715                 720 


Val Ala Asp Leu Lys Lys Asn Lys Arg Val Lys Asp Lys Met Leu Ser 
                725                 730                 735     


Glu Ala Glu Lys Leu Glu Thr Arg Trp Leu Ile Lys Asn Glu Arg Ile 
            740                 745                 750         


Lys Lys Ala Ser Arg Gly Thr Cys Pro Tyr Thr Gly Asp Arg Leu Ala 
        755                 760                 765             


Glu Gly Gly Glu Ile Asp His Ile Leu Pro Arg Ser Leu Ile Lys Asp 
    770                 775                 780                 


Ala Arg Gly Ile Val Phe Asn Ala Glu Pro Asn Leu Ile Tyr Ala Ser 
785                 790                 795                 800 


Ser Arg Gly Asn Gln Leu Lys Lys Asn Gln Arg Tyr Ser Leu Ser Asp 
                805                 810                 815     


Leu Lys Ala Asn Tyr Arg Asn Glu Ile Phe Lys Thr Ser Asn Ile Ala 
            820                 825                 830         


Ala Ile Thr Ala Glu Ile Glu Asp Val Val Thr Lys Leu Gln Gln Thr 
        835                 840                 845             


His Arg Leu Lys Phe Phe Asp Leu Leu Asn Glu His Glu Gln Asp Cys 
    850                 855                 860                 


Val Arg His Ala Leu Phe Leu Asp Asp Gly Ser Glu Ala Arg Asp Ala 
865                 870                 875                 880 


Val Leu Glu Leu Leu Ala Thr Gln Arg Arg Thr Arg Val Asn Gly Thr 
                885                 890                 895     


Gln Ile Trp Met Ile Lys Asn Leu Ala Asn Lys Ile Arg Glu Glu Leu 
            900                 905                 910         


Gln Asn Trp Cys Lys Thr Thr Asn Asn Arg Leu His Phe Gln Ala Ala 
        915                 920                 925             


Ala Thr Asn Val Ser Asp Ala Lys Asn Leu Arg Leu Lys Leu Ala Gln 
    930                 935                 940                 


Asn Gln Pro Asp Phe Glu Lys Pro Asp Ile Gln Pro Ile Ala Ser His 
945                 950                 955                 960 


Ser Ile Asp Ala Leu Cys Ser Phe Ala Val Gly Ser Ala Asp Ala Glu 
                965                 970                 975     


Arg Asp Gln Asn Gly Phe Asp Tyr Leu Asp Gly Lys Thr Val Leu Gly 
            980                 985                 990         


Leu Tyr Pro Gln Ser Cys Glu Val  Ile His Leu Gln Ala  Lys Pro Gln 
        995                 1000                 1005             


Glu Glu  Lys Ser His Phe Asp  Ser Val Ala Ile Phe  Lys Glu Gly 
    1010                 1015                 1020             


Ile Tyr  Ala Glu Gln Phe Leu  Pro Ile Phe Thr Leu  Asn Glu Lys 
    1025                 1030                 1035             


Ile Trp  Ile Gly Tyr Glu Thr  Leu Asn Ala Lys Gly  Glu Arg Cys 
    1040                 1045                 1050             


Gly Ala  Ile Glu Val Ser Gly  Lys Gln Pro Lys Glu  Leu Leu Glu 
    1055                 1060                 1065             


Met Leu  Ala Pro Phe Phe Asn  Lys Pro Val Gly Asp  Leu Ser Ala 
    1070                 1075                 1080             


His Ala  Thr Tyr Arg Ile Leu  Lys Lys Pro Ala Tyr  Glu Phe Leu 
    1085                 1090                 1095             


Ala Lys  Ala Ala Leu Gln Pro  Leu Ser Ala Glu Glu  Lys Arg Leu 
    1100                 1105                 1110             


Ala Ala  Leu Leu Asp Ala Leu  Arg Tyr Cys Thr Ser  Arg Lys Ser 
    1115                 1120                 1125             


Leu Met  Ser Leu Phe Met Ala  Ala Asn Gly Lys Ser  Leu Lys Lys 
    1130                 1135                 1140             


Arg Glu  Asp Val Leu Lys Pro  Lys Leu Phe Gln Leu  Lys Val Glu 
    1145                 1150                 1155             


Leu Lys  Gly Glu Lys Ser Phe  Lys Leu Asn Gly Ser  Leu Thr Leu 
    1160                 1165                 1170             


Pro Val  Lys Gln Asp Trp Leu  Arg Ile Cys Asp Ser  Pro Glu Leu 
    1175                 1180                 1185             


Ala Asp  Ala Phe Gly Lys Pro  Cys Ser Ala Asp Glu  Leu Thr Ser 
    1190                 1195                 1200             


Lys Leu  Ala Arg Ile Trp Lys  Arg Pro Val Met Arg  Asp Leu Ala 
    1205                 1210                 1215             


His Ala  Pro Val Arg Arg Glu  Phe Ser Leu Pro Ala  Ile Asp Asn 
    1220                 1225                 1230             


Pro Ser  Gly Gly Phe Arg Ile  Arg Arg Thr Asn Leu  Phe Gly Asn 
    1235                 1240                 1245             


Glu Leu  Tyr Gln Val His Ala  Ile Asn Ala Lys Lys  Tyr Arg Gly 
    1250                 1255                 1260             


Phe Ala  Ser Ala Gly Ser Asn  Val Asp Trp Ser Lys  Gly Ile Leu 
    1265                 1270                 1275             


Phe Asn  Glu Leu Gln His Glu  Asn Leu Thr Glu Cys  Gly Gly Arg 
    1280                 1285                 1290             


Phe Ile  Thr Ser Ala Asp Val  Thr Pro Met Ser Glu  Trp Arg Lys 
    1295                 1300                 1305             


Val Val  Ala Glu Asp Asn Leu  Ser Ile Trp Ile Ala  Pro Gly Thr 
    1310                 1315                 1320             


Glu Gly  Arg Arg Tyr Val Arg  Val Glu Thr Thr Phe  Ile Gln Ala 
    1325                 1330                 1335             


Ser His  Trp Phe Glu Gln Ser  Val Glu Asn Trp Ala  Ile Thr Ser 
    1340                 1345                 1350             


Pro Leu  Ser Leu Pro Ala Ser  Phe Lys Val Asp Lys  Pro Ala Glu 
    1355                 1360                 1365             


Phe Gln  Lys Ala Val Gly Thr  Glu Leu Ser Glu Leu  Leu Gly Gln 
    1370                 1375                 1380             


Pro Arg  Ser Glu Ile Phe Ile  Glu Asn Val Gly Asn  Ala Lys His 
    1385                 1390                 1395             


Ile Arg  Phe Trp Tyr Ile Val  Val Ser Ser Asn Lys  Lys Met Asn 
    1400                 1405                 1410             


Glu Ser  Tyr Asn Asn Val Ser  Lys Ser 
    1415                 1420         


<210> 601
<211> 1049
<212> PRT
<213> Tistrella mobilis

<400> 601
Met Ile Asn Glu Arg Leu Thr Phe Gly Ile Asp Leu Gly Ile Gly Ser 
1               5                   10                  15      


Cys Gly Trp Ala Val Leu Arg His Ala Asp Ala Ala Gly Glu Pro Gly 
            20                  25                  30          


Val Ile Glu Gly Leu Gly Ser Trp Cys Phe Asp Val Pro Glu Thr Ser 
        35                  40                  45              


Lys Glu Arg Ile Pro Thr Asn Gln Val Arg Arg Ser Asn Arg Leu Leu 
    50                  55                  60                  


Arg Arg Val Ile Arg Arg Arg Arg Asn Arg Met Ala Glu Ile Arg Arg 
65                  70                  75                  80  


Leu Phe His Ala Gln Gly Leu Leu Pro Ser Ala Asp Glu Asp Ala Leu 
                85                  90                  95      


Lys Arg Pro Arg Leu Asp Pro Trp Glu Leu Arg Ala Arg Gly Leu Asp 
            100                 105                 110         


Gln Cys Leu Ser Ala Glu Glu Phe Ala Val Ala Leu Gly His Ile Ala 
        115                 120                 125             


Arg His Arg Gly Phe Arg Ser Ser Ala Lys Arg Lys Ala Ala Asn Thr 
    130                 135                 140                 


Ser Gly Glu Asp Ser Lys Met Leu Ser Ala Leu Leu Val Thr Arg Glu 
145                 150                 155                 160 


Arg Thr Ala Arg Tyr Arg Thr Val Gly Glu Met Phe Ala Arg Asp Pro 
                165                 170                 175     


Glu Tyr Ser Ala Arg Arg Arg Asn Arg Asp Gly Ile Phe Asp Arg Thr 
            180                 185                 190         


Val Ala Arg Asp Asp Leu Ile His Glu Val Gly Lys Leu Phe Glu Ala 
        195                 200                 205             


Gln Arg Ala Arg Gly Ser Ala Phe Ala Ser Pro Asp Leu Glu Ala Asp 
    210                 215                 220                 


Phe Asn Ala Ile Ala Phe Arg Gln Ala Glu Met Gln Asp Ser Glu Arg 
225                 230                 235                 240 


Leu Val Gly Asn Cys Pro Phe Glu Arg Asp Glu Lys Arg Ala Ala Arg 
                245                 250                 255     


Trp Ala Pro Ser Phe Glu Arg Phe Arg Leu Leu Thr Arg Leu Ile Asn 
            260                 265                 270         


Leu Arg Ile Ala Thr Ala Glu Gly Glu Arg Arg Phe Thr Pro Glu Asp 
        275                 280                 285             


Leu Ala Arg Val Ser Ala Glu Leu Gly Ala Thr Ala Lys Leu Pro Val 
    290                 295                 300                 


Ser Arg Val Arg Ala Leu Ile Gly Leu Leu Pro Asp Glu Arg Phe Thr 
305                 310                 315                 320 


Thr Ile Arg Val Glu Asp Glu Asp Arg Asp Ile Val Ala Arg Thr Gly 
                325                 330                 335     


Glu Ala Ala Pro Gly Thr Trp Arg Leu Arg Lys Thr Leu Gly Glu Ala 
            340                 345                 350         


Leu Trp Ala Glu Met Gln Ala Arg Pro Asp Gln Leu Asp Ala Ile Ala 
        355                 360                 365             


His Val Leu Ser Phe Phe Glu Ala Thr Ala Lys Ile Arg Ser Glu Leu 
    370                 375                 380                 


Asp Arg Leu Gly Leu Pro Ala Ala Val Ile Glu Ala Leu Asp Arg Gly 
385                 390                 395                 400 


Leu Glu Asp Gly Ala Phe Ala Lys Phe Lys Gly Ala Gly His Ile Ser 
                405                 410                 415     


Ala Lys Ala Cys Arg Asn Leu Leu Pro His Leu Gln Gln Gly His Arg 
            420                 425                 430         


Tyr Asp Gln Ala Cys Arg Leu Ala Gly Tyr Asp His Ala Ala Ser Thr 
        435                 440                 445             


Leu Ser His Thr Ala Gln Val Val Ser Lys Ala Gly Phe Asn Ala Leu 
    450                 455                 460                 


Val Thr Glu Leu Gly Glu Ser Ile Ala Asn Pro Ile Ala Arg Lys Ala 
465                 470                 475                 480 


Leu Thr Glu Gly Leu Lys Gln Ile Arg Ala Met Cys Ala Arg Trp Gly 
                485                 490                 495     


Leu Pro Gly Ala Ile His Ile Glu Leu Ala Arg Glu Val Gly Asn Ser 
            500                 505                 510         


Ile Glu Lys Arg Arg Glu Leu Glu Ser Gln Arg Glu Thr Thr Thr Lys 
        515                 520                 525             


Arg Arg Gln Thr Glu Arg Asp Glu Ile Arg Gly Leu Leu Ala Leu Glu 
    530                 535                 540                 


Asp Val Asp Asp Asp Thr Leu Leu Arg Tyr Arg Leu Trp Lys Glu Gln 
545                 550                 555                 560 


Gly Gly Lys Cys Leu Tyr Thr Gly Lys Asp Ile His Val Arg Gln Leu 
                565                 570                 575     


Ile Ala Thr Asp Asn Ser Val Gln Val Asp His Ile Leu Pro Trp Ser 
            580                 585                 590         


Arg Phe Gly Asp Asp Ser Phe Asn Asn Lys Thr Leu Cys Leu Ala Ser 
        595                 600                 605             


Ala Asn Gln Arg Lys Arg Gly Gln Thr Pro Trp Glu Trp Phe Ser Leu 
    610                 615                 620                 


Thr Gly Thr Pro Glu Ala Trp Glu Val Phe Ala Ser Arg Val Glu Thr 
625                 630                 635                 640 


Ser Lys Asp Leu Arg Gly Phe Lys Lys Arg Asn Leu Leu Leu Lys Asn 
                645                 650                 655     


Ala Asp Glu Val Ala Gln Arg Phe Arg Ser Arg Asn Leu Asn Asp Thr 
            660                 665                 670         


Arg Tyr Ala Ala Arg Leu Leu Ala Glu Ala Ala Lys Leu Phe Tyr Pro 
        675                 680                 685             


Ala Gly Asp Arg Gln Glu Lys Asp Gly Arg Arg Arg Val Leu Thr Arg 
    690                 695                 700                 


Pro Gly Pro Leu Thr Ala Ala Leu Arg His Ala Trp Gly Leu Glu Ser 
705                 710                 715                 720 


Leu Lys Lys Ala Asp Gly Lys Arg Val Ser Asp Asp Arg His His Ala 
                725                 730                 735     


Leu Asp Ala Leu Ala Val Ala Ala Ile Ser Glu Arg Glu Val Gln Arg 
            740                 745                 750         


Leu Thr Arg Ser Phe Gln Glu Trp Glu Gln Gln Gly Leu Ala Arg Pro 
        755                 760                 765             


Leu Arg His Val Ala Pro Pro Trp Pro Gly Phe Arg Gly Asp Val Leu 
    770                 775                 780                 


Ala Ala Tyr Ala Gln Ala Phe Val Ala Arg Pro Glu Arg Arg Arg Ala 
785                 790                 795                 800 


Arg Gly Lys Gly His Asp Ala Ser Ile Arg Gln Val Val Gly Glu Gly 
                805                 810                 815     


Pro Glu Ala Gln Val Phe Glu Arg Arg Gly Leu Ala Asp Leu Lys Glu 
            820                 825                 830         


Ala Asp Leu Asp Arg Val Lys Asp Pro Glu Arg Asn Gln Ala Ile Ile 
        835                 840                 845             


Glu Ala Val Arg Ala Trp Ile Leu Ala Gly Arg Pro Ala Asp Ala Pro 
    850                 855                 860                 


Pro Arg Ser Pro Arg Gly Asp Val Ile Val Lys Leu Arg Thr Ala Pro 
865                 870                 875                 880 


Ala Lys Lys Ile Lys Pro Ala Val Pro Val Arg Gly Gly Thr Ala Asp 
                885                 890                 895     


Arg Gly Asp Met Val Arg Ile Asp Val Phe Thr Arg Pro Asn Arg Lys 
            900                 905                 910         


Gly Arg Asp Glu Trp Tyr Leu Val Pro Ile Tyr Pro His Gln Val Met 
        915                 920                 925             


Asn Arg Lys Ala Trp Pro His Pro Pro Met Arg Ser Val Val Ala Tyr 
    930                 935                 940                 


Lys Asp Glu Ala Gly Trp Thr Glu Ile Gly Ala Glu His Ser Phe Arg 
945                 950                 955                 960 


Phe Ser Leu Tyr Pro Arg Ser Tyr Val Gln Leu Val Lys Ser Asn Gly 
                965                 970                 975     


Asp Val Ile Glu Gly Tyr Leu Val Ser Met Asp Arg Ser Thr Gly Ala 
            980                 985                 990         


Phe Arg Val Phe Val His Asn Asn  Pro Ala Glu Met Ala  Lys Gly Ile 
        995                 1000                 1005             


Gly Ala  Lys Thr Leu Leu Asn  Leu Arg Lys Phe Asn  Val Asp Arg 
    1010                 1015                 1020             


Phe Gly  Val Arg Thr Glu Val  Lys Ser Glu Val Arg  Thr Trp His 
    1025                 1030                 1035             


Gly Glu  Val Cys Thr Ser Pro  Val Pro Pro Asp 
    1040                 1045                 


<210> 602
<211> 1395
<212> PRT
<213> Treponema denticola


<220>
<223> Treponema denticola AL-2

<400> 602
Met Lys Lys Glu Ile Lys Asp Tyr Phe Leu Gly Leu Asp Val Gly Thr 
1               5                   10                  15      


Gly Ser Val Gly Trp Ala Val Thr Asp Thr Asp Tyr Lys Leu Leu Lys 
            20                  25                  30          


Ala Asn Arg Lys Asp Leu Trp Gly Met Arg Cys Phe Glu Thr Ala Glu 
        35                  40                  45              


Thr Ala Glu Val Arg Arg Leu His Arg Gly Ala Arg Arg Arg Ile Glu 
    50                  55                  60                  


Arg Arg Lys Lys Arg Ile Lys Leu Leu Gln Glu Leu Phe Ser Gln Glu 
65                  70                  75                  80  


Ile Ala Lys Ile Asp Glu Gly Phe Phe Gln Arg Met Lys Glu Ser Pro 
                85                  90                  95      


Phe Tyr Ala Glu Asp Lys Thr Ile Leu Gln Glu Asn Ala Leu Phe Asn 
            100                 105                 110         


Asp Lys Asp Phe Thr Asp Lys Thr Tyr His Lys Ala Tyr Pro Thr Ile 
        115                 120                 125             


Asn His Leu Ile Lys Ala Trp Ile Glu Asn Lys Val Lys Pro Asp Pro 
    130                 135                 140                 


Arg Leu Leu Tyr Leu Ala Cys His Asn Ile Ile Lys Lys Arg Gly His 
145                 150                 155                 160 


Phe Leu Phe Glu Gly Asp Phe Asp Ser Glu Asn Gln Phe Asp Thr Ser 
                165                 170                 175     


Ile Gln Ala Leu Phe Glu Tyr Leu Arg Glu Asp Met Glu Val Asp Ile 
            180                 185                 190         


Asp Ala Asp Ser Gln Lys Val Lys Glu Ile Leu Lys Asp Ser Ser Leu 
        195                 200                 205             


Lys Asn Ser Glu Lys Gln Ser Arg Leu Asn Lys Ile Leu Gly Leu Lys 
    210                 215                 220                 


Pro Ser Asp Lys Gln Lys Lys Ala Ile Thr Asn Leu Ile Ser Gly Asn 
225                 230                 235                 240 


Lys Ile Asn Phe Ala Asp Leu Tyr Asp Asn Pro Asp Leu Lys Asp Ala 
                245                 250                 255     


Glu Lys Asn Ser Ile Ser Phe Ser Lys Asp Asp Phe Asp Ala Leu Ser 
            260                 265                 270         


Asp Asp Leu Ala Ser Ile Leu Gly Asp Ser Phe Glu Leu Leu Leu Lys 
        275                 280                 285             


Ala Lys Ala Val Tyr Asn Cys Ser Val Leu Ser Lys Val Ile Gly Asp 
    290                 295                 300                 


Glu Gln Tyr Leu Ser Phe Ala Lys Val Lys Ile Tyr Glu Lys His Lys 
305                 310                 315                 320 


Thr Asp Leu Thr Lys Leu Lys Ala Val Ile Lys Lys His Phe Pro Asn 
                325                 330                 335     


Asn Tyr Lys Lys Val Phe Gly Tyr Asn Gln Asp Asn Glu Ser Lys Asn 
            340                 345                 350         


Asn Tyr Ser Gly Tyr Val Gly Val Cys Lys Thr Lys Asn Lys Lys Leu 
        355                 360                 365             


Val Ile Asn Asn Ser Val Asn Gln Glu Asp Phe Tyr Lys Phe Leu Lys 
    370                 375                 380                 


Pro Ile Leu Ser Ala Lys Ser Glu Ile Lys Glu Val Asn Asp Ile Leu 
385                 390                 395                 400 


Ala Glu Ile Glu Thr Gly Asn Phe Leu Pro Lys Gln Ile Ser Lys Ser 
                405                 410                 415     


Asn Ala Glu Ile Pro Tyr Gln Leu Arg Lys Met Glu Leu Glu Lys Ile 
            420                 425                 430         


Leu Ser Asn Ala Glu Lys His Phe Ser Phe Leu Lys Gln Lys Asp Glu 
        435                 440                 445             


Lys Gly Leu Ser His Ser Glu Lys Ile Ile Met Leu Leu Thr Phe Lys 
    450                 455                 460                 


Ile Pro Tyr Tyr Ile Gly Pro Ile Asn Asp Asn His Lys Lys Ser Phe 
465                 470                 475                 480 


Pro Asp Arg Cys Trp Val Val Lys Lys Glu Lys Ser Pro Ser Gly Lys 
                485                 490                 495     


Thr Thr Pro Trp Asn Phe Phe Asp His Ile Asp Lys Glu Lys Thr Ala 
            500                 505                 510         


Glu Glu Phe Ile Thr Ser Arg Thr Asn Phe Cys Thr Tyr Leu Ile Gly 
        515                 520                 525             


Glu Ser Val Leu Pro Lys Asn Ser Leu Leu Tyr Ser Glu Tyr Thr Val 
    530                 535                 540                 


Leu Asn Glu Ile Asn Asn Leu Gln Ile Ile Ile Asp Gly Lys Asn Ile 
545                 550                 555                 560 


Cys Asp Thr Lys Leu Lys Gln Lys Ile Tyr Glu Asp Leu Phe Lys Lys 
                565                 570                 575     


Tyr Lys Lys Ile Thr Gln Lys Gln Ile Ser Thr Phe Ile Lys His Glu 
            580                 585                 590         


Gly Ile Cys Asn Lys Thr Asp Glu Val Ile Ile Leu Gly Ile Asp Lys 
        595                 600                 605             


Glu Cys Thr Ser Ser Leu Lys Ser Tyr Ile Glu Leu Lys Asn Ile Phe 
    610                 615                 620                 


Gly Lys Gln Val Asp Glu Ile Ser Thr Lys Asn Met Leu Glu Glu Ile 
625                 630                 635                 640 


Ile Arg Trp Ala Thr Ile Tyr Asp Glu Gly Glu Gly Lys Thr Ile Leu 
                645                 650                 655     


Lys Thr Lys Ile Lys Ala Glu Tyr Gly Lys Tyr Cys Ser Asp Glu Gln 
            660                 665                 670         


Ile Lys Lys Ile Leu Asn Leu Lys Phe Ser Gly Trp Gly Arg Leu Ser 
        675                 680                 685             


Arg Lys Phe Leu Glu Thr Val Thr Ser Glu Met Pro Gly Phe Ser Glu 
    690                 695                 700                 


Pro Val Asn Ile Ile Thr Ala Met Arg Glu Thr Gln Asn Asn Leu Met 
705                 710                 715                 720 


Glu Leu Leu Ser Ser Glu Phe Lys Phe Thr Glu Asn Ile Lys Lys Ile 
                725                 730                 735     


Asn Ser Gly Phe Glu Asp Ala Glu Lys Gln Phe Ser Tyr Asp Gly Leu 
            740                 745                 750         


Val Lys Pro Leu Phe Leu Ser Pro Ser Val Lys Lys Met Leu Trp Gln 
        755                 760                 765             


Thr Leu Lys Leu Val Lys Glu Ile Ser His Ile Thr Gln Ala Pro Pro 
    770                 775                 780                 


Lys Lys Ile Phe Ile Glu Met Ala Lys Gly Ala Glu Leu Glu Pro Ala 
785                 790                 795                 800 


Arg Thr Lys Thr Arg Leu Lys Ile Leu Gln Asp Leu Tyr Ser Ser Cys 
                805                 810                 815     


Lys Asn Asp Ala Asp Ala Phe Ser Ser Glu Ile Gln Tyr Leu Ser Gly 
            820                 825                 830         


Lys Ile Glu Asn Glu Asp Asn Leu Arg Leu Arg Ser Asp Lys Leu Tyr 
        835                 840                 845             


Leu Tyr Tyr Thr Gln Leu Gly Lys Cys Met Tyr Cys Gly Lys Pro Ile 
    850                 855                 860                 


Glu Ile Gly His Val Phe Asp Thr Ser Asn Tyr Asp Ile Asp His Ile 
865                 870                 875                 880 


Tyr Pro Gln Ser Lys Ile Lys Asp Asp Ser Ile Ser Asn Arg Val Leu 
                885                 890                 895     


Val Cys Ser Ser Cys Asn Lys Asn Lys Glu Asp Lys Tyr Pro Leu Lys 
            900                 905                 910         


Ser Glu Ile Gln Ser Lys Gln Arg Gly Phe Trp Asn Phe Leu Gln Arg 
        915                 920                 925             


Asn Asn Phe Ile Ser Leu Glu Lys Leu Asn Arg Leu Thr Arg Thr Thr 
    930                 935                 940                 


Pro Ile Ser Asp Asp Glu Thr Ala Lys Phe Ile Ala Arg Gln Leu Val 
945                 950                 955                 960 


Glu Thr Arg Gln Ala Thr Lys Val Ala Ala Lys Val Leu Glu Lys Met 
                965                 970                 975     


Phe Pro Glu Thr Lys Ile Val Tyr Ser Lys Ala Glu Thr Val Ser Met 
            980                 985                 990         


Phe Arg Asn Lys Phe Asp Ile Ile  Lys Cys Arg Glu Ile  Asn Asp Phe 
        995                 1000                 1005             


His His  Ala His Asp Ala Tyr  Leu Asn Ile Val Val  Gly Asn Val 
    1010                 1015                 1020             


Tyr Asn  Thr Lys Phe Thr Asn  Asn Pro Trp Asn Phe  Ile Lys Glu 
    1025                 1030                 1035             


Lys Arg  Asp Asn Pro Lys Ile  Ala Asp Thr Tyr Asn  Tyr Tyr Lys 
    1040                 1045                 1050             


Val Phe  Asp Tyr Asp Val Lys  Arg Asn Asn Ile Thr  Ala Trp Glu 
    1055                 1060                 1065             


Lys Gly  Lys Thr Ile Ile Thr  Val Lys Asp Met Leu  Lys Arg Asn 
    1070                 1075                 1080             


Thr Pro  Ile Tyr Thr Arg Gln  Ala Ala Cys Lys Lys  Gly Gly Leu 
    1085                 1090                 1095             


Phe Asp  Gln Thr Ile Met Lys  Lys Gly Leu Gly Gln  His Pro Leu 
    1100                 1105                 1110             


Lys Lys  Glu Gly Pro Phe Ser  Asn Ile Ser Lys Tyr  Gly Gly Tyr 
    1115                 1120                 1125             


Asn Lys  Val Ser Ala Ala Tyr  Tyr Thr Leu Ile Glu  Tyr Glu Glu 
    1130                 1135                 1140             


Lys Gly  Asn Lys Ile Arg Ser  Leu Glu Thr Ile Pro  Leu Tyr Leu 
    1145                 1150                 1155             


Val Lys  Asp Ile Gln Lys Asp  Gln Asp Val Leu Lys  Ser Tyr Leu 
    1160                 1165                 1170             


Thr Asp  Leu Leu Gly Lys Lys  Glu Phe Lys Ile Leu  Val Pro Lys 
    1175                 1180                 1185             


Ile Lys  Ile Asn Ser Leu Leu  Lys Ile Asn Gly Phe  Pro Cys His 
    1190                 1195                 1200             


Ile Thr  Gly Lys Thr Asn Asp  Ser Phe Leu Leu Arg  Pro Ala Val 
    1205                 1210                 1215             


Gln Phe  Cys Cys Ser Asn Asp  Glu Val Leu Tyr Phe  Lys Lys Ile 
    1220                 1225                 1230             


Ile Arg  Phe Ser Glu Ile Arg  Ser Gln Arg Glu Lys  Ile Gly Lys 
    1235                 1240                 1245             


Thr Ile  Ser Pro Tyr Glu Asp  Leu Ser Phe Arg Ser  Tyr Ile Lys 
    1250                 1255                 1260             


Glu Asn  Leu Cys Lys Lys Thr  Lys Asn Asp Glu Ile  Gly Glu Lys 
    1265                 1270                 1275             


Glu Phe  Tyr Asp Leu Leu Gln  Lys Lys Asn Leu Glu  Ile Tyr Asp 
    1280                 1285                 1290             


Met Leu  Leu Thr Lys His Lys  Asp Thr Ile Tyr Lys  Lys Arg Pro 
    1295                 1300                 1305             


Asn Ser  Ala Thr Ile Asp Ile  Leu Val Lys Gly Lys  Glu Lys Phe 
    1310                 1315                 1320             


Lys Ser  Leu Ile Ile Glu Asn  Gln Phe Glu Val Ile  Leu Glu Ile 
    1325                 1330                 1335             


Leu Lys  Leu Phe Ser Ala Thr  Arg Asn Val Ser Glu  Leu Gln His 
    1340                 1345                 1350             


Ile Gly  Gly Ser Lys Tyr Ser  Gly Val Ala Lys Ile  Gly Asn Lys 
    1355                 1360                 1365             


Ile Ser  Ser Leu Asp Asn Cys  Ile Leu Ile Tyr Gln  Ser Ile Thr 
    1370                 1375                 1380             


Gly Ile  Phe Glu Lys Arg Ile  Asp Leu Leu Lys Val  
    1385                 1390                 1395 


<210> 603
<211> 1395
<212> PRT
<213> Treponema denticola


<220>
<223> Treponema denticola ASLM

<400> 603
Met Lys Lys Glu Ile Lys Asp Tyr Phe Leu Gly Leu Asp Val Gly Thr 
1               5                   10                  15      


Gly Ser Val Gly Trp Ala Val Thr Asp Thr Asp Tyr Lys Leu Leu Lys 
            20                  25                  30          


Ala Asn Arg Lys Asp Leu Trp Gly Met Arg Cys Phe Glu Thr Ala Glu 
        35                  40                  45              


Thr Ala Glu Val Arg Arg Leu His Arg Gly Ala Arg Arg Arg Ile Glu 
    50                  55                  60                  


Arg Arg Lys Lys Arg Ile Lys Leu Leu Gln Glu Leu Phe Ser Gln Glu 
65                  70                  75                  80  


Ile Ala Lys Ile Asp Glu Gly Phe Phe Gln Arg Met Lys Glu Ser Pro 
                85                  90                  95      


Leu Tyr Ala Glu Asp Lys Thr Ile Leu Gln Glu Asn Thr Leu Phe Asn 
            100                 105                 110         


Asp Lys Asp Phe Thr Asp Lys Thr Tyr His Lys Ala Tyr Pro Thr Ile 
        115                 120                 125             


Asn His Leu Ile Lys Ala Trp Ile Glu Asn Lys Val Lys Pro Asp Pro 
    130                 135                 140                 


Arg Leu Leu Tyr Leu Ala Cys His Asn Ile Ile Lys Lys Arg Gly His 
145                 150                 155                 160 


Phe Leu Phe Glu Gly Asp Phe Asp Ser Glu Asn Gln Phe Asp Thr Ser 
                165                 170                 175     


Ile Gln Ala Leu Phe Glu Tyr Leu Arg Glu Asp Met Glu Val Asp Ile 
            180                 185                 190         


Asp Ala Asp Ser Gln Lys Val Lys Glu Ile Leu Lys Asp Ser Ser Leu 
        195                 200                 205             


Lys Asn Ser Glu Lys Gln Ser Arg Leu Asn Lys Met Leu Gly Leu Lys 
    210                 215                 220                 


Pro Ser Asp Lys Gln Lys Lys Ala Ile Thr Asn Leu Ile Ser Gly Asn 
225                 230                 235                 240 


Lys Ile Asn Phe Ala Asp Leu Tyr Asp Asn Pro Asp Leu Lys Asp Ala 
                245                 250                 255     


Glu Lys Asn Ser Ile Ser Phe Ser Lys Asp Asp Phe Asp Ala Leu Ser 
            260                 265                 270         


Asp Asp Leu Ala Ser Ile Leu Gly Asp Ser Phe Glu Leu Leu Leu Lys 
        275                 280                 285             


Ala Lys Ala Val Tyr Asn Cys Ser Val Leu Ser Lys Val Ile Gly Asp 
    290                 295                 300                 


Glu Gln Tyr Leu Ser Phe Ala Lys Val Lys Ile Tyr Glu Lys His Lys 
305                 310                 315                 320 


Thr Asp Leu Thr Lys Leu Lys Asn Val Ile Lys Lys His Phe Pro Lys 
                325                 330                 335     


Asp Tyr Lys Lys Val Phe Gly Tyr Asn Lys Asn Glu Lys Asn Asn Asn 
            340                 345                 350         


Asn Tyr Ser Gly Tyr Val Gly Val Cys Lys Thr Lys Ser Lys Lys Leu 
        355                 360                 365             


Ile Ile Asn Asn Ser Val Asn Gln Glu Asp Phe Tyr Lys Phe Leu Lys 
    370                 375                 380                 


Thr Ile Leu Ser Ala Lys Ser Glu Ile Lys Glu Val Asn Asp Ile Leu 
385                 390                 395                 400 


Thr Glu Ile Glu Thr Gly Thr Phe Leu Pro Lys Gln Ile Ser Lys Ser 
                405                 410                 415     


Asn Ala Glu Ile Pro Tyr Gln Leu Arg Lys Met Glu Leu Glu Lys Ile 
            420                 425                 430         


Leu Ser Asn Ala Glu Lys His Phe Ser Phe Leu Lys Gln Lys Asp Glu 
        435                 440                 445             


Lys Gly Leu Ser His Ser Glu Lys Ile Ile Met Leu Leu Thr Phe Lys 
    450                 455                 460                 


Ile Pro Tyr Tyr Ile Gly Pro Ile Asn Asp Asn His Lys Lys Ser Phe 
465                 470                 475                 480 


Pro Asp Arg Cys Trp Val Val Lys Lys Glu Lys Ser Pro Ser Gly Lys 
                485                 490                 495     


Thr Thr Pro Trp Asn Phe Phe Asp His Ile Asp Lys Glu Lys Thr Ala 
            500                 505                 510         


Glu Glu Phe Ile Thr Ser Arg Thr Asn Phe Cys Thr Tyr Leu Ile Gly 
        515                 520                 525             


Glu Ser Val Leu Pro Lys Asn Ser Leu Leu Tyr Ser Glu Tyr Thr Val 
    530                 535                 540                 


Leu Asn Glu Ile Asn Asn Leu Gln Ile Ile Ile Asp Gly Lys Asn Ile 
545                 550                 555                 560 


Cys Asp Thr Lys Leu Lys Gln Lys Ile Tyr Glu Glu Leu Phe Lys Lys 
                565                 570                 575     


Tyr Lys Lys Ile Thr Gln Lys Gln Ile Ser Thr Phe Ile Lys His Glu 
            580                 585                 590         


Gly Ile Cys Asn Lys Thr Asp Glu Val Ile Ile Leu Gly Ile Asp Lys 
        595                 600                 605             


Glu Cys Thr Ser Ser Leu Lys Ser Tyr Ile Glu Leu Lys Asn Ile Phe 
    610                 615                 620                 


Gly Lys Gln Val Asp Glu Ile Ser Thr Lys Asn Met Leu Glu Glu Ile 
625                 630                 635                 640 


Ile Arg Trp Ala Thr Ile Tyr Asp Glu Gly Glu Gly Lys Thr Ile Leu 
                645                 650                 655     


Lys Thr Lys Ile Lys Ala Glu Tyr Gly Lys Tyr Cys Ser Asp Glu Gln 
            660                 665                 670         


Ile Lys Lys Ile Leu Asn Leu Lys Phe Ser Gly Trp Gly Arg Leu Ser 
        675                 680                 685             


Arg Lys Phe Leu Glu Thr Val Thr Ser Glu Met Pro Gly Phe Ser Glu 
    690                 695                 700                 


Pro Val Asn Ile Ile Thr Ala Met Arg Glu Thr Gln Asn Asn Leu Met 
705                 710                 715                 720 


Glu Leu Leu Ser Ser Glu Phe Lys Phe Thr Glu Asn Ile Lys Lys Ile 
                725                 730                 735     


Asn Ser Gly Phe Glu Asp Val Glu Lys Gln Phe Ser Tyr Asp Gly Leu 
            740                 745                 750         


Val Lys Pro Leu Phe Leu Ser Pro Ser Val Lys Lys Met Leu Trp Gln 
        755                 760                 765             


Thr Leu Lys Leu Val Lys Glu Ile Ser His Ile Thr Gln Ala Pro Pro 
    770                 775                 780                 


Lys Lys Ile Phe Ile Glu Met Ala Lys Gly Ala Glu Leu Asp Pro Val 
785                 790                 795                 800 


Arg Thr Lys Thr Arg Leu Lys Ile Leu Gln Asp Leu Tyr Asn Asn Cys 
                805                 810                 815     


Lys Asn Asp Ala Asp Ala Phe Ser Ser Glu Ile Lys Asp Leu Ser Gly 
            820                 825                 830         


Lys Ile Glu Asn Glu Asp Asn Leu Arg Leu Arg Ser Asp Lys Leu Tyr 
        835                 840                 845             


Leu Tyr Tyr Thr Gln Leu Gly Lys Cys Met Tyr Cys Gly Lys Pro Ile 
    850                 855                 860                 


Glu Ile Gly His Val Phe Asp Thr Ser Asn Tyr Asp Ile Asp His Ile 
865                 870                 875                 880 


Tyr Pro Gln Ser Lys Ile Lys Asp Asp Ser Ile Ser Asn Arg Val Leu 
                885                 890                 895     


Val Cys Ser Ser Cys Asn Lys Asn Lys Glu Asp Lys Tyr Pro Leu Lys 
            900                 905                 910         


Ala Glu Ile Gln Ser Lys Gln Arg Gly Phe Trp Asn Phe Leu Gln Arg 
        915                 920                 925             


Asn Asn Phe Ile Ser Leu Glu Lys Phe Asn Arg Leu Thr Arg Ala Thr 
    930                 935                 940                 


Pro Ile Ser Asp Asp Glu Thr Ala Lys Phe Ile Ala Arg Gln Leu Val 
945                 950                 955                 960 


Glu Thr Arg Gln Ala Thr Lys Val Ala Ala Arg Val Leu Glu Lys Met 
                965                 970                 975     


Phe Pro Glu Thr Lys Ile Val Tyr Ser Lys Ala Glu Thr Val Ser Met 
            980                 985                 990         


Phe Arg Asn Lys Phe Asp Ile Val  Lys Cys Arg Glu Ile  Asn Asp Phe 
        995                 1000                 1005             


His His  Ala His Asp Ala Tyr  Leu Asn Ile Val Val  Gly Asn Val 
    1010                 1015                 1020             


Tyr Asn  Thr Lys Phe Thr Asn  Asn Leu Trp Asn Phe  Ile Lys Glu 
    1025                 1030                 1035             


Lys Arg  Asp Asn Pro Lys Ile  Ala Asp Thr Tyr Asn  Tyr Tyr Lys 
    1040                 1045                 1050             


Val Phe  Asp Tyr Asp Val Lys  Arg Asn Asn Ile Thr  Ala Trp Glu 
    1055                 1060                 1065             


Lys Gly  Lys Thr Ile Ile Thr  Val Lys Asp Met Leu  Lys Arg Asn 
    1070                 1075                 1080             


Thr Pro  Ile Tyr Thr Arg Gln  Ala Ala Cys Lys Lys  Gly Gly Leu 
    1085                 1090                 1095             


Phe Asp  Gln Thr Ile Met Lys  Lys Gly Leu Gly Gln  His Pro Leu 
    1100                 1105                 1110             


Lys Lys  Glu Gly Pro Phe Ser  Asn Ile Ser Lys Tyr  Gly Gly Tyr 
    1115                 1120                 1125             


Asn Lys  Val Ser Ala Ala Tyr  Tyr Thr Leu Ile Glu  Tyr Glu Glu 
    1130                 1135                 1140             


Lys Gly  Asn Lys Ile Arg Ser  Leu Glu Thr Ile Pro  Leu Tyr Leu 
    1145                 1150                 1155             


Val Lys  Asp Ile Gln Lys Asp  Gln Asp Val Leu Lys  Ser Tyr Leu 
    1160                 1165                 1170             


Thr Asp  Leu Leu Gly Lys Lys  Glu Phe Lys Ile Leu  Val Pro Lys 
    1175                 1180                 1185             


Ile Lys  Ile Asn Ser Leu Leu  Lys Ile Asn Gly Phe  Pro Cys His 
    1190                 1195                 1200             


Ile Thr  Gly Lys Thr Asn Asp  Ser Phe Leu Leu Arg  Pro Ala Val 
    1205                 1210                 1215             


Gln Phe  Cys Cys Ser Asn Asp  Glu Val Leu Tyr Phe  Lys Lys Ile 
    1220                 1225                 1230             


Ile Arg  Phe Ser Glu Ile Arg  Ser Gln Arg Glu Lys  Ile Gly Lys 
    1235                 1240                 1245             


Thr Ile  Ser Pro Tyr Glu Asp  Leu Ser Phe Arg Ser  Tyr Ile Lys 
    1250                 1255                 1260             


Glu Asn  Leu Cys Lys Lys Thr  Lys Asn Asp Glu Ile  Gly Glu Lys 
    1265                 1270                 1275             


Glu Phe  Tyr Asp Leu Leu Gln  Lys Lys Asn Leu Glu  Ile Tyr Asp 
    1280                 1285                 1290             


Met Leu  Leu Thr Lys His Lys  Asp Thr Ile Tyr Lys  Lys Arg Pro 
    1295                 1300                 1305             


Asn Ser  Ala Thr Ile Asp Ile  Leu Val Lys Gly Lys  Glu Lys Phe 
    1310                 1315                 1320             


Lys Ser  Leu Ile Ile Glu Asn  Gln Phe Glu Val Ile  Leu Glu Ile 
    1325                 1330                 1335             


Leu Lys  Leu Phe Ser Ala Thr  Arg Asn Val Ser Asp  Leu Gln His 
    1340                 1345                 1350             


Ile Gly  Gly Ser Lys Tyr Ser  Gly Val Ala Lys Ile  Gly Asn Lys 
    1355                 1360                 1365             


Ile Ser  Ser Leu Asp Asn Cys  Ile Leu Ile Tyr Gln  Ser Ile Thr 
    1370                 1375                 1380             


Gly Ile  Phe Glu Lys Arg Ile  Asp Leu Leu Lys Val  
    1385                 1390                 1395 


<210> 604
<211> 1395
<212> PRT
<213> Treponema denticola


<220>
<223> Treponema denticola ATCC 35405

<400> 604
Met Lys Lys Glu Ile Lys Asp Tyr Phe Leu Gly Leu Asp Val Gly Thr 
1               5                   10                  15      


Gly Ser Val Gly Trp Ala Val Thr Asp Thr Asp Tyr Lys Leu Leu Lys 
            20                  25                  30          


Ala Asn Arg Lys Asp Leu Trp Gly Met Arg Cys Phe Glu Thr Ala Glu 
        35                  40                  45              


Thr Ala Glu Val Arg Arg Leu His Arg Gly Ala Arg Arg Arg Ile Glu 
    50                  55                  60                  


Arg Arg Lys Lys Arg Ile Lys Leu Leu Gln Glu Leu Phe Ser Gln Glu 
65                  70                  75                  80  


Ile Ala Lys Thr Asp Glu Gly Phe Phe Gln Arg Met Lys Glu Ser Pro 
                85                  90                  95      


Phe Tyr Ala Glu Asp Lys Thr Ile Leu Gln Glu Asn Thr Leu Phe Asn 
            100                 105                 110         


Asp Lys Asp Phe Ala Asp Lys Thr Tyr His Lys Ala Tyr Pro Thr Ile 
        115                 120                 125             


Asn His Leu Ile Lys Ala Trp Ile Glu Asn Lys Val Lys Pro Asp Pro 
    130                 135                 140                 


Arg Leu Leu Tyr Leu Ala Cys His Asn Ile Ile Lys Lys Arg Gly His 
145                 150                 155                 160 


Phe Leu Phe Glu Gly Asp Phe Asp Ser Glu Asn Gln Phe Asp Thr Ser 
                165                 170                 175     


Ile Gln Ala Leu Phe Glu Tyr Leu Arg Glu Asp Met Glu Val Asp Ile 
            180                 185                 190         


Asp Ala Asp Ser Gln Lys Val Lys Glu Ile Leu Lys Asp Ser Ser Leu 
        195                 200                 205             


Lys Asn Ser Glu Lys Gln Ser Arg Leu Asn Lys Ile Leu Gly Leu Lys 
    210                 215                 220                 


Pro Ser Asp Lys Gln Lys Lys Ala Ile Thr Asn Leu Ile Ser Gly Asn 
225                 230                 235                 240 


Lys Ile Asn Phe Ala Asp Leu Tyr Asp Asn Pro Asp Leu Lys Asp Ala 
                245                 250                 255     


Glu Lys Asn Ser Ile Ser Phe Ser Lys Asp Asp Phe Asp Ala Leu Ser 
            260                 265                 270         


Asp Asp Leu Ala Ser Ile Leu Gly Asp Ser Phe Glu Leu Leu Leu Lys 
        275                 280                 285             


Ala Lys Ala Val Tyr Asn Cys Ser Val Leu Ser Lys Val Ile Gly Asp 
    290                 295                 300                 


Glu Gln Tyr Leu Ser Phe Ala Lys Val Lys Ile Tyr Glu Lys His Lys 
305                 310                 315                 320 


Thr Asp Leu Thr Lys Leu Lys Asn Val Ile Lys Lys His Phe Pro Lys 
                325                 330                 335     


Asp Tyr Lys Lys Val Phe Gly Tyr Asn Lys Asn Glu Lys Asn Asn Asn 
            340                 345                 350         


Asn Tyr Ser Gly Tyr Val Gly Val Cys Lys Thr Lys Ser Lys Lys Leu 
        355                 360                 365             


Ile Ile Asn Asn Ser Val Asn Gln Glu Asp Phe Tyr Lys Phe Leu Lys 
    370                 375                 380                 


Thr Ile Leu Ser Ala Lys Ser Glu Ile Lys Glu Val Asn Asp Ile Leu 
385                 390                 395                 400 


Thr Glu Ile Glu Thr Gly Thr Phe Leu Pro Lys Gln Ile Ser Lys Ser 
                405                 410                 415     


Asn Ala Glu Ile Pro Tyr Gln Leu Arg Lys Met Glu Leu Glu Lys Ile 
            420                 425                 430         


Leu Ser Asn Ala Glu Lys His Phe Ser Phe Leu Lys Gln Lys Asp Glu 
        435                 440                 445             


Lys Gly Leu Ser His Ser Glu Lys Ile Ile Met Leu Leu Thr Phe Lys 
    450                 455                 460                 


Ile Pro Tyr Tyr Ile Gly Pro Ile Asn Asp Asn His Lys Lys Phe Phe 
465                 470                 475                 480 


Pro Asp Arg Cys Trp Val Val Lys Lys Glu Lys Ser Pro Ser Gly Lys 
                485                 490                 495     


Thr Thr Pro Trp Asn Phe Phe Asp His Ile Asp Lys Glu Lys Thr Ala 
            500                 505                 510         


Glu Ala Phe Ile Thr Ser Arg Thr Asn Phe Cys Thr Tyr Leu Val Gly 
        515                 520                 525             


Glu Ser Val Leu Pro Lys Ser Ser Leu Leu Tyr Ser Glu Tyr Thr Val 
    530                 535                 540                 


Leu Asn Glu Ile Asn Asn Leu Gln Ile Ile Ile Asp Gly Lys Asn Ile 
545                 550                 555                 560 


Cys Asp Ile Lys Leu Lys Gln Lys Ile Tyr Glu Asp Leu Phe Lys Lys 
                565                 570                 575     


Tyr Lys Lys Ile Thr Gln Lys Gln Ile Ser Thr Phe Ile Lys His Glu 
            580                 585                 590         


Gly Ile Cys Asn Lys Thr Asp Glu Val Ile Ile Leu Gly Ile Asp Lys 
        595                 600                 605             


Glu Cys Thr Ser Ser Leu Lys Ser Tyr Ile Glu Leu Lys Asn Ile Phe 
    610                 615                 620                 


Gly Lys Gln Val Asp Glu Ile Ser Thr Lys Asn Met Leu Glu Glu Ile 
625                 630                 635                 640 


Ile Arg Trp Ala Thr Ile Tyr Asp Glu Gly Glu Gly Lys Thr Ile Leu 
                645                 650                 655     


Lys Thr Lys Ile Lys Ala Glu Tyr Gly Lys Tyr Cys Ser Asp Glu Gln 
            660                 665                 670         


Ile Lys Lys Ile Leu Asn Leu Lys Phe Ser Gly Trp Gly Arg Leu Ser 
        675                 680                 685             


Arg Lys Phe Leu Glu Thr Val Thr Ser Glu Met Pro Gly Phe Ser Glu 
    690                 695                 700                 


Pro Val Asn Ile Ile Thr Ala Met Arg Glu Thr Gln Asn Asn Leu Met 
705                 710                 715                 720 


Glu Leu Leu Ser Ser Glu Phe Thr Phe Thr Glu Asn Ile Lys Lys Ile 
                725                 730                 735     


Asn Ser Gly Phe Glu Asp Ala Glu Lys Gln Phe Ser Tyr Asp Gly Leu 
            740                 745                 750         


Val Lys Pro Leu Phe Leu Ser Pro Ser Val Lys Lys Met Leu Trp Gln 
        755                 760                 765             


Thr Leu Lys Leu Val Lys Glu Ile Ser His Ile Thr Gln Ala Pro Pro 
    770                 775                 780                 


Lys Lys Ile Phe Ile Glu Met Ala Lys Gly Ala Glu Leu Glu Pro Ala 
785                 790                 795                 800 


Arg Thr Lys Thr Arg Leu Lys Ile Leu Gln Asp Leu Tyr Asn Asn Cys 
                805                 810                 815     


Lys Asn Asp Ala Asp Ala Phe Ser Ser Glu Ile Lys Asp Leu Ser Gly 
            820                 825                 830         


Lys Ile Glu Asn Glu Asp Asn Leu Arg Leu Arg Ser Asp Lys Leu Tyr 
        835                 840                 845             


Leu Tyr Tyr Thr Gln Leu Gly Lys Cys Met Tyr Cys Gly Lys Pro Ile 
    850                 855                 860                 


Glu Ile Gly His Val Phe Asp Thr Ser Asn Tyr Asp Ile Asp His Ile 
865                 870                 875                 880 


Tyr Pro Gln Ser Lys Ile Lys Asp Asp Ser Ile Ser Asn Arg Val Leu 
                885                 890                 895     


Val Cys Ser Ser Cys Asn Lys Asn Lys Glu Asp Lys Tyr Pro Leu Lys 
            900                 905                 910         


Ser Glu Ile Gln Ser Lys Gln Arg Gly Phe Trp Asn Phe Leu Gln Arg 
        915                 920                 925             


Asn Asn Phe Ile Ser Leu Glu Lys Leu Asn Arg Leu Thr Arg Ala Thr 
    930                 935                 940                 


Pro Ile Ser Asp Asp Glu Thr Ala Lys Phe Ile Ala Arg Gln Leu Val 
945                 950                 955                 960 


Glu Thr Arg Gln Ala Thr Lys Val Ala Ala Lys Val Leu Glu Lys Met 
                965                 970                 975     


Phe Pro Glu Thr Lys Ile Val Tyr Ser Lys Ala Glu Thr Val Ser Met 
            980                 985                 990         


Phe Arg Asn Lys Phe Asp Ile Val  Lys Cys Arg Glu Ile  Asn Asp Phe 
        995                 1000                 1005             


His His  Ala His Asp Ala Tyr  Leu Asn Ile Val Val  Gly Asn Val 
    1010                 1015                 1020             


Tyr Asn  Thr Lys Phe Thr Asn  Asn Pro Trp Asn Phe  Ile Lys Glu 
    1025                 1030                 1035             


Lys Arg  Asp Asn Pro Lys Ile  Ala Asp Thr Tyr Asn  Tyr Tyr Lys 
    1040                 1045                 1050             


Val Phe  Asp Tyr Asp Val Lys  Arg Asn Asn Ile Thr  Ala Trp Glu 
    1055                 1060                 1065             


Lys Gly  Lys Thr Ile Ile Thr  Val Lys Asp Met Leu  Lys Arg Asn 
    1070                 1075                 1080             


Thr Pro  Ile Tyr Thr Arg Gln  Ala Ala Cys Lys Lys  Gly Glu Leu 
    1085                 1090                 1095             


Phe Asn  Gln Thr Ile Met Lys  Lys Gly Leu Gly Gln  His Pro Leu 
    1100                 1105                 1110             


Lys Lys  Glu Gly Pro Phe Ser  Asn Ile Ser Lys Tyr  Gly Gly Tyr 
    1115                 1120                 1125             


Asn Lys  Val Ser Ala Ala Tyr  Tyr Thr Leu Ile Glu  Tyr Glu Glu 
    1130                 1135                 1140             


Lys Gly  Asn Lys Ile Arg Ser  Leu Glu Thr Ile Pro  Leu Tyr Leu 
    1145                 1150                 1155             


Val Lys  Asp Ile Gln Lys Asp  Gln Asp Val Leu Lys  Ser Tyr Leu 
    1160                 1165                 1170             


Thr Asp  Leu Leu Gly Lys Lys  Glu Phe Lys Ile Leu  Val Pro Lys 
    1175                 1180                 1185             


Ile Lys  Ile Asn Ser Leu Leu  Lys Ile Asn Gly Phe  Pro Cys His 
    1190                 1195                 1200             


Ile Thr  Gly Lys Thr Asn Asp  Ser Phe Leu Leu Arg  Pro Ala Val 
    1205                 1210                 1215             


Gln Phe  Cys Cys Ser Asn Asn  Glu Val Leu Tyr Phe  Lys Lys Ile 
    1220                 1225                 1230             


Ile Arg  Phe Ser Glu Ile Arg  Ser Gln Arg Glu Lys  Ile Gly Lys 
    1235                 1240                 1245             


Thr Ile  Ser Pro Tyr Glu Asp  Leu Ser Phe Arg Ser  Tyr Ile Lys 
    1250                 1255                 1260             


Glu Asn  Leu Trp Lys Lys Thr  Lys Asn Asp Glu Ile  Gly Glu Lys 
    1265                 1270                 1275             


Glu Phe  Tyr Asp Leu Leu Gln  Lys Lys Asn Leu Glu  Ile Tyr Asp 
    1280                 1285                 1290             


Met Leu  Leu Thr Lys His Lys  Asp Thr Ile Tyr Lys  Lys Arg Pro 
    1295                 1300                 1305             


Asn Ser  Ala Thr Ile Asp Ile  Leu Val Lys Gly Lys  Glu Lys Phe 
    1310                 1315                 1320             


Lys Ser  Leu Ile Ile Glu Asn  Gln Phe Glu Val Ile  Leu Glu Ile 
    1325                 1330                 1335             


Leu Lys  Leu Phe Ser Ala Thr  Arg Asn Val Ser Asp  Leu Gln His 
    1340                 1345                 1350             


Ile Gly  Gly Ser Lys Tyr Ser  Gly Val Ala Lys Ile  Gly Asn Lys 
    1355                 1360                 1365             


Ile Ser  Ser Leu Asp Asn Cys  Ile Leu Ile Tyr Gln  Ser Ile Thr 
    1370                 1375                 1380             


Gly Ile  Phe Glu Lys Arg Ile  Asp Leu Leu Lys Val  
    1385                 1390                 1395 


<210> 605
<211> 1395
<212> PRT
<213> Treponema denticola


<220>
<223> Treponema denticola H1-T

<400> 605
Met Lys Lys Glu Ile Lys Asp Tyr Phe Leu Gly Leu Asp Val Gly Thr 
1               5                   10                  15      


Gly Ser Val Gly Trp Ala Val Thr Asp Thr Asp Tyr Lys Leu Leu Lys 
            20                  25                  30          


Ala Asn Arg Lys Asp Leu Trp Gly Met Arg Cys Phe Glu Thr Ala Glu 
        35                  40                  45              


Thr Ala Glu Val Arg Arg Leu His Arg Gly Ala Arg Arg Arg Ile Glu 
    50                  55                  60                  


Arg Arg Lys Lys Arg Ile Lys Leu Leu Gln Glu Leu Phe Ser Gln Glu 
65                  70                  75                  80  


Ile Ala Lys Ile Asp Glu Gly Phe Phe Gln Arg Met Lys Glu Ser Pro 
                85                  90                  95      


Phe Tyr Ala Glu Asp Lys Thr Ile Leu Gln Glu Asn Ala Leu Phe Asn 
            100                 105                 110         


Asp Lys Asp Phe Thr Asp Lys Thr Tyr His Lys Ala Tyr Pro Thr Ile 
        115                 120                 125             


Asn His Leu Ile Lys Ala Trp Ile Glu Asn Lys Val Lys Pro Asp Pro 
    130                 135                 140                 


Arg Leu Leu Tyr Leu Ala Cys His Asn Ile Ile Lys Lys Arg Gly His 
145                 150                 155                 160 


Phe Leu Phe Glu Gly Asp Phe Asp Ser Glu Asn Gln Phe Asp Thr Ser 
                165                 170                 175     


Ile Gln Ala Leu Phe Glu Tyr Leu Arg Glu Asp Met Glu Val Asp Ile 
            180                 185                 190         


Asp Ala Asp Ser Gln Lys Val Lys Glu Ile Leu Lys Asp Ser Ser Leu 
        195                 200                 205             


Lys Asn Ser Glu Lys Gln Ser Arg Leu Asn Lys Ile Leu Gly Leu Lys 
    210                 215                 220                 


Pro Ser Asp Lys Gln Lys Lys Ala Ile Thr Asn Leu Ile Ser Gly Asn 
225                 230                 235                 240 


Lys Ile Asn Phe Ala Asp Leu Tyr Asp Asn Pro Asp Leu Lys Asp Ala 
                245                 250                 255     


Glu Lys Asn Ser Ile Ser Phe Ser Lys Asp Asp Phe Asp Ala Leu Ser 
            260                 265                 270         


Asp Asp Leu Ala Ser Ile Leu Gly Asp Ser Phe Glu Leu Leu Leu Lys 
        275                 280                 285             


Ala Lys Ala Val Tyr Asn Cys Ser Val Leu Ser Lys Val Ile Gly Asp 
    290                 295                 300                 


Glu Gln Tyr Leu Ser Phe Ala Lys Val Lys Ile Tyr Glu Lys His Lys 
305                 310                 315                 320 


Thr Asp Leu Thr Lys Leu Lys Ala Val Ile Lys Lys His Phe Pro Asn 
                325                 330                 335     


Asn Tyr Lys Lys Val Phe Gly Tyr Asn Gln Asp Asn Glu Ser Lys Asn 
            340                 345                 350         


Asn Tyr Ser Gly Tyr Val Gly Val Cys Lys Thr Lys Asn Lys Lys Leu 
        355                 360                 365             


Val Ile Asn Asn Ser Val Asn Gln Glu Asp Phe Tyr Lys Phe Leu Lys 
    370                 375                 380                 


Pro Ile Leu Ser Ala Lys Ser Glu Ile Lys Glu Val Asn Asp Ile Leu 
385                 390                 395                 400 


Ala Glu Ile Glu Thr Gly Asn Phe Leu Pro Lys Gln Ile Ser Lys Ser 
                405                 410                 415     


Asn Ala Glu Ile Pro Tyr Gln Leu Arg Lys Met Glu Leu Glu Lys Ile 
            420                 425                 430         


Leu Ser Asn Ala Glu Lys His Phe Ser Phe Leu Lys Gln Lys Asp Glu 
        435                 440                 445             


Lys Gly Leu Ser His Ser Glu Lys Ile Ile Met Leu Leu Thr Phe Lys 
    450                 455                 460                 


Ile Pro Tyr Tyr Ile Gly Pro Ile Asn Asp Asn His Lys Lys Ser Phe 
465                 470                 475                 480 


Pro Asp Arg Cys Trp Val Val Lys Lys Glu Lys Ser Pro Ser Gly Lys 
                485                 490                 495     


Thr Thr Pro Trp Asn Phe Phe Asp His Ile Asp Lys Glu Lys Thr Ala 
            500                 505                 510         


Glu Glu Phe Ile Thr Ser Arg Thr Asn Phe Cys Thr Tyr Leu Ile Gly 
        515                 520                 525             


Glu Ser Val Leu Pro Lys Asn Ser Leu Leu Tyr Ser Glu Tyr Thr Val 
    530                 535                 540                 


Leu Asn Glu Ile Asn Asn Leu Gln Ile Ile Ile Asp Gly Lys Asn Ile 
545                 550                 555                 560 


Cys Asp Thr Lys Leu Lys Gln Lys Ile Tyr Glu Asp Leu Phe Lys Lys 
                565                 570                 575     


Tyr Lys Lys Ile Thr Gln Lys Gln Ile Ser Thr Phe Ile Lys His Glu 
            580                 585                 590         


Gly Ile Cys Asn Lys Thr Asp Glu Val Ile Ile Leu Gly Ile Asp Lys 
        595                 600                 605             


Glu Cys Thr Ser Ser Leu Lys Ser Tyr Ile Glu Leu Lys Asn Ile Phe 
    610                 615                 620                 


Gly Lys Gln Val Asp Glu Ile Ser Thr Lys Asn Met Leu Glu Glu Ile 
625                 630                 635                 640 


Ile Arg Trp Ala Thr Ile Tyr Asp Glu Gly Glu Gly Lys Thr Ile Leu 
                645                 650                 655     


Lys Thr Lys Ile Lys Ala Glu Tyr Gly Lys Tyr Cys Ser Asp Glu Gln 
            660                 665                 670         


Ile Lys Lys Ile Leu Asn Leu Lys Phe Ser Gly Trp Gly Arg Leu Ser 
        675                 680                 685             


Arg Lys Phe Leu Glu Thr Val Thr Ser Glu Met Pro Gly Phe Ser Glu 
    690                 695                 700                 


Pro Val Asn Ile Ile Thr Ala Met Arg Glu Thr Gln Asn Asn Leu Met 
705                 710                 715                 720 


Glu Leu Leu Ser Ser Glu Phe Lys Phe Thr Glu Asn Ile Lys Lys Ile 
                725                 730                 735     


Asn Ser Gly Phe Glu Asp Ala Glu Lys Gln Phe Ser Tyr Asp Gly Leu 
            740                 745                 750         


Val Lys Pro Leu Phe Leu Ser Pro Ser Val Lys Lys Met Leu Trp Gln 
        755                 760                 765             


Thr Leu Lys Leu Val Lys Glu Ile Ser His Ile Thr Gln Ala Pro Pro 
    770                 775                 780                 


Lys Lys Ile Phe Ile Glu Met Ala Lys Gly Ala Glu Leu Glu Pro Ala 
785                 790                 795                 800 


Arg Thr Lys Thr Arg Leu Lys Ile Leu Gln Asp Leu Tyr Ser Ser Cys 
                805                 810                 815     


Lys Asn Asp Ala Asp Ala Phe Ser Ser Glu Ile Gln Tyr Leu Ser Gly 
            820                 825                 830         


Lys Ile Glu Asn Glu Asp Asn Leu Arg Leu Arg Ser Asp Lys Leu Tyr 
        835                 840                 845             


Leu Tyr Tyr Thr Gln Leu Gly Lys Cys Met Tyr Cys Gly Lys Pro Ile 
    850                 855                 860                 


Glu Ile Gly His Val Phe Asp Thr Ser Asn Tyr Asp Ile Asp His Ile 
865                 870                 875                 880 


Tyr Pro Gln Ser Lys Ile Lys Asp Asp Ser Ile Ser Asn Arg Val Leu 
                885                 890                 895     


Val Cys Ser Ser Cys Asn Lys Asn Lys Glu Asp Lys Tyr Pro Leu Lys 
            900                 905                 910         


Ser Glu Ile Gln Ser Lys Gln Arg Gly Phe Trp Asn Phe Leu Gln Arg 
        915                 920                 925             


Asn Asn Phe Ile Ser Leu Glu Lys Leu Asn Arg Leu Thr Arg Thr Thr 
    930                 935                 940                 


Pro Ile Ser Asp Asp Glu Thr Ala Lys Phe Ile Ala Arg Gln Leu Val 
945                 950                 955                 960 


Glu Thr Arg Gln Ala Thr Lys Val Ala Ala Lys Val Leu Glu Lys Met 
                965                 970                 975     


Phe Pro Glu Thr Lys Ile Val Tyr Ser Lys Ala Glu Thr Val Ser Met 
            980                 985                 990         


Phe Arg Asn Lys Phe Asp Ile Ile  Lys Cys Arg Glu Ile  Asn Asp Phe 
        995                 1000                 1005             


His His  Ala His Asp Ala Tyr  Leu Asn Ile Val Val  Gly Asn Val 
    1010                 1015                 1020             


Tyr Asn  Thr Lys Phe Thr Asn  Asn Pro Trp Asn Phe  Ile Lys Glu 
    1025                 1030                 1035             


Lys Arg  Asp Asn Pro Lys Ile  Ala Asp Thr Tyr Asn  Tyr Tyr Lys 
    1040                 1045                 1050             


Val Phe  Asp Tyr Asp Val Lys  Arg Asn Asn Ile Thr  Ala Trp Glu 
    1055                 1060                 1065             


Lys Gly  Lys Thr Ile Ile Thr  Val Lys Asp Met Leu  Lys Arg Asn 
    1070                 1075                 1080             


Thr Pro  Ile Tyr Thr Arg Gln  Ala Ala Cys Lys Lys  Gly Glu Leu 
    1085                 1090                 1095             


Phe Asn  Gln Thr Ile Met Lys  Lys Gly Leu Gly Gln  His Pro Leu 
    1100                 1105                 1110             


Lys Lys  Glu Gly Pro Phe Ser  Asn Ile Ser Lys Tyr  Gly Gly Tyr 
    1115                 1120                 1125             


Asn Lys  Val Ser Ala Ala Tyr  Tyr Thr Leu Ile Glu  Tyr Glu Glu 
    1130                 1135                 1140             


Lys Val  Asn Lys Ile Arg Ser  Leu Glu Thr Ile Pro  Leu Tyr Leu 
    1145                 1150                 1155             


Val Lys  Asp Ile Gln Lys Asp  Gln Asp Val Leu Lys  Ser Tyr Leu 
    1160                 1165                 1170             


Thr Asp  Leu Leu Gly Lys Lys  Glu Ile Lys Ile Leu  Val Pro Lys 
    1175                 1180                 1185             


Ile Lys  Ile Asn Ser Leu Leu  Lys Ile Asn Gly Phe  Pro Cys His 
    1190                 1195                 1200             


Ile Thr  Gly Lys Thr Gly Asp  Ser Phe Val Leu Arg  Pro Ala Val 
    1205                 1210                 1215             


Gln Phe  Cys Cys Ser Asn Asp  Glu Val Leu Tyr Phe  Lys Lys Ile 
    1220                 1225                 1230             


Ile Arg  Phe Asn Glu Ile Arg  Ser Gln Arg Glu Lys  Met Gly Lys 
    1235                 1240                 1245             


Thr Ile  Ser Pro Tyr Glu Asp  Leu Ser Phe Arg Ser  Tyr Ile Lys 
    1250                 1255                 1260             


Glu Asn  Leu Cys Lys Lys Thr  Lys Ala Asp Glu Ile  Gly Glu Lys 
    1265                 1270                 1275             


Glu Phe  Tyr Asp Leu Leu Gln  Lys Lys Asn Leu Glu  Ile Tyr Asp 
    1280                 1285                 1290             


Met Leu  Leu Thr Lys His Lys  Asp Thr Ile Tyr Asn  Lys Arg Pro 
    1295                 1300                 1305             


Asn Ser  Thr Thr Leu Gly Met  Leu Thr Lys Gly Arg  Tyr Glu Phe 
    1310                 1315                 1320             


Ile Asn  Leu Lys Pro Lys Asp  Gln Ile Ile Val Met  Leu Glu Ile 
    1325                 1330                 1335             


Leu Lys  Leu Phe Cys Thr Thr  Arg Glu Ala Ile Asp  Leu Gly Leu 
    1340                 1345                 1350             


Ile Lys  Gly Lys Pro Ala Ala  Gly Val Ala Thr Leu  Gly Lys Lys 
    1355                 1360                 1365             


Ile Ser  Asn Leu Asp Asn Cys  Ile Leu Ile Tyr Gln  Ser Ile Thr 
    1370                 1375                 1380             


Gly Ile  Phe Glu Lys Arg Ile  Asp Leu Leu Lys Val  
    1385                 1390                 1395 


<210> 606
<211> 1395
<212> PRT
<213> Treponema denticola


<220>
<223> Treponema denticola H-22

<400> 606
Met Lys Lys Glu Ile Lys Asp Tyr Phe Leu Gly Leu Asp Val Gly Thr 
1               5                   10                  15      


Gly Ser Val Gly Trp Ala Val Thr Asp Thr Asp Tyr Lys Leu Leu Lys 
            20                  25                  30          


Ala Asn Arg Lys Asp Leu Trp Gly Met Arg Cys Phe Glu Thr Ala Glu 
        35                  40                  45              


Thr Ala Glu Val Arg Arg Leu His Arg Gly Ala Arg Arg Arg Ile Glu 
    50                  55                  60                  


Arg Arg Lys Lys Arg Ile Lys Leu Leu Gln Glu Leu Phe Ser Gln Glu 
65                  70                  75                  80  


Ile Ala Lys Ile Asp Glu Gly Phe Phe Gln Arg Met Lys Glu Ser Pro 
                85                  90                  95      


Phe Tyr Ala Glu Asp Lys Thr Ile Leu Gln Glu Asn Thr Leu Phe Asn 
            100                 105                 110         


Asp Lys Asp Phe Thr Asp Lys Thr Tyr His Lys Ala Tyr Pro Thr Ile 
        115                 120                 125             


Asn His Leu Ile Lys Ala Trp Ile Glu Asn Lys Val Lys Pro Asp Pro 
    130                 135                 140                 


Arg Leu Leu Tyr Leu Ala Cys His Asn Ile Ile Lys Lys Arg Gly His 
145                 150                 155                 160 


Phe Leu Phe Glu Gly Asp Phe Asp Ser Glu Asn Gln Phe Asp Thr Ser 
                165                 170                 175     


Ile Gln Ala Leu Phe Glu Tyr Leu Arg Glu Asp Met Glu Val Asp Ile 
            180                 185                 190         


Asp Ala Asp Ser Gln Lys Val Lys Glu Ile Leu Lys Asp Ser Ser Leu 
        195                 200                 205             


Lys Asn Ser Glu Lys Gln Ser Arg Leu Asn Lys Ile Leu Gly Leu Lys 
    210                 215                 220                 


Pro Ser Asp Lys Gln Lys Lys Ala Ile Thr Asn Leu Ile Ser Gly Asn 
225                 230                 235                 240 


Lys Ile Asn Phe Ala Asp Leu Tyr Asp Asn Pro Asp Leu Lys Asp Ala 
                245                 250                 255     


Glu Lys Asn Ser Ile Ser Phe Ser Lys Asp Asp Phe Asp Ala Leu Ser 
            260                 265                 270         


Asp Asp Leu Ala Ser Ile Leu Gly Asp Ser Phe Glu Leu Leu Leu Lys 
        275                 280                 285             


Ala Lys Ala Val Tyr Asn Cys Ser Val Leu Ser Lys Val Ile Gly Asp 
    290                 295                 300                 


Glu Gln Tyr Leu Ser Phe Ala Lys Val Lys Ile Tyr Glu Lys His Lys 
305                 310                 315                 320 


Thr Asp Leu Thr Lys Leu Lys Asn Val Ile Lys Lys His Phe Pro Lys 
                325                 330                 335     


Asp Tyr Lys Lys Val Phe Gly Tyr Asn Lys Asn Glu Lys Asn Asn Asn 
            340                 345                 350         


Asn Tyr Ser Gly Tyr Val Gly Val Cys Lys Thr Lys Ser Lys Lys Leu 
        355                 360                 365             


Ile Ile Asn Asn Ser Val Asn Gln Glu Asp Phe Tyr Lys Phe Leu Lys 
    370                 375                 380                 


Thr Ile Leu Ser Ala Lys Ser Glu Ile Lys Glu Val Asn Asp Ile Leu 
385                 390                 395                 400 


Thr Glu Ile Glu Thr Gly Thr Phe Leu Pro Lys Gln Ile Ser Lys Ser 
                405                 410                 415     


Asn Ala Glu Ile Pro Tyr Gln Leu Arg Lys Met Glu Leu Glu Lys Ile 
            420                 425                 430         


Leu Ser Asn Ala Glu Lys His Phe Ser Phe Leu Lys Gln Lys Asp Glu 
        435                 440                 445             


Lys Gly Leu Ser His Ser Glu Lys Ile Ile Met Leu Leu Thr Phe Lys 
    450                 455                 460                 


Ile Pro Tyr Tyr Ile Gly Pro Ile Asn Asp Asn His Lys Lys Ser Phe 
465                 470                 475                 480 


Pro Asp Arg Cys Trp Val Ile Lys Lys Glu Lys Ser Pro Ser Gly Lys 
                485                 490                 495     


Thr Thr Pro Trp Asn Phe Phe Asp His Ile Asp Lys Asp Lys Thr Ala 
            500                 505                 510         


Glu Ala Phe Ile Thr Ser Arg Thr Asn Phe Cys Thr Tyr Leu Val Gly 
        515                 520                 525             


Glu Ser Val Leu Pro Lys Ser Ser Leu Leu Tyr Ser Glu Tyr Thr Val 
    530                 535                 540                 


Leu Asn Glu Ile Asn Asn Leu Gln Ile Ile Ile Asp Gly Lys Asn Ile 
545                 550                 555                 560 


Cys Asp Ile Lys Leu Lys Gln Lys Ile Tyr Glu Glu Leu Phe Lys Lys 
                565                 570                 575     


Tyr Lys Lys Ile Thr Gln Lys Gln Ile Ser Thr Phe Ile Lys His Glu 
            580                 585                 590         


Gly Ile Cys Asn Lys Thr Asp Glu Val Ile Ile Leu Gly Ile Asp Lys 
        595                 600                 605             


Glu Cys Thr Ser Ser Leu Lys Ser Tyr Ile Glu Leu Lys Asn Ile Phe 
    610                 615                 620                 


Gly Lys Gln Val Asp Glu Ile Ser Thr Lys Asn Met Leu Glu Glu Ile 
625                 630                 635                 640 


Ile Arg Trp Ala Thr Ile Tyr Asp Glu Gly Glu Gly Lys Thr Ile Leu 
                645                 650                 655     


Lys Thr Lys Ile Lys Ala Glu Tyr Gly Lys Tyr Cys Ser Asp Glu Gln 
            660                 665                 670         


Ile Lys Lys Ile Leu Asn Leu Lys Phe Ser Gly Trp Gly Arg Leu Ser 
        675                 680                 685             


Arg Lys Phe Leu Glu Thr Val Thr Ser Glu Met Pro Gly Phe Ser Glu 
    690                 695                 700                 


Pro Val Asn Ile Ile Thr Ala Met Arg Glu Thr Gln Asn Asn Leu Met 
705                 710                 715                 720 


Glu Leu Leu Ser Ser Glu Phe Lys Phe Thr Glu Asn Ile Lys Lys Ile 
                725                 730                 735     


Asn Ser Gly Phe Glu Asp Ala Glu Lys Gln Phe Ser Tyr Asn Gly Leu 
            740                 745                 750         


Val Lys Pro Leu Phe Leu Ser Pro Ser Val Lys Lys Met Leu Trp Gln 
        755                 760                 765             


Thr Leu Lys Leu Val Lys Glu Ile Ser His Ile Thr Gln Ala Pro Pro 
    770                 775                 780                 


Lys Lys Ile Phe Ile Glu Met Ala Lys Gly Ala Glu Leu Glu Pro Ala 
785                 790                 795                 800 


Arg Thr Lys Thr Arg Leu Lys Ile Leu Gln Asp Leu Tyr Asn Asn Cys 
                805                 810                 815     


Lys Asn Asp Ala Asp Ala Phe Ser Ser Glu Ile Lys Asp Leu Ser Gly 
            820                 825                 830         


Lys Ile Glu Asn Glu Asp Asn Leu Arg Leu Arg Ser Asp Lys Leu Tyr 
        835                 840                 845             


Leu Tyr Tyr Thr Gln Leu Gly Lys Cys Met Tyr Cys Gly Lys Pro Ile 
    850                 855                 860                 


Glu Ile Gly His Val Phe Asp Thr Ser Asn Tyr Asp Ile Asp His Ile 
865                 870                 875                 880 


Tyr Pro Gln Ser Lys Ile Lys Asp Asp Ser Ile Ser Asn Arg Val Leu 
                885                 890                 895     


Val Cys Ser Ser Cys Asn Lys Asn Lys Glu Asp Lys Tyr Pro Leu Lys 
            900                 905                 910         


Ser Glu Ile Gln Ser Lys Gln Arg Gly Phe Trp Asn Phe Leu Gln Arg 
        915                 920                 925             


Asn Asn Phe Ile Ser Leu Glu Lys Leu Asn Arg Leu Thr Arg Thr Thr 
    930                 935                 940                 


Pro Ile Ser Asp Asp Glu Thr Ala Lys Phe Ile Ala Arg Gln Leu Val 
945                 950                 955                 960 


Glu Thr Arg Gln Ala Thr Lys Val Ala Ala Lys Val Leu Glu Lys Met 
                965                 970                 975     


Phe Pro Glu Thr Lys Ile Val Tyr Ser Lys Ala Glu Thr Val Ser Met 
            980                 985                 990         


Phe Arg Asn Lys Phe Asp Ile Ile  Lys Cys Arg Glu Ile  Asn Asp Phe 
        995                 1000                 1005             


His His  Ala His Asp Ala Tyr  Leu Asn Ile Val Val  Gly Asn Val 
    1010                 1015                 1020             


Tyr Asn  Thr Lys Phe Thr Asn  Asn Pro Trp Asn Phe  Ile Lys Glu 
    1025                 1030                 1035             


Lys Arg  Asp Asn Pro Lys Ile  Ala Asp Thr Tyr Asn  Tyr Tyr Lys 
    1040                 1045                 1050             


Val Phe  Asp Tyr Asp Val Lys  Arg Asn Asn Ile Thr  Ala Trp Glu 
    1055                 1060                 1065             


Lys Gly  Lys Thr Ile Ile Thr  Val Lys Asp Met Leu  Lys Arg Asn 
    1070                 1075                 1080             


Thr Pro  Ile Tyr Thr Arg Gln  Ala Ala Cys Lys Lys  Gly Gly Leu 
    1085                 1090                 1095             


Phe Asp  Gln Thr Ile Met Lys  Lys Gly Leu Gly Gln  His Pro Leu 
    1100                 1105                 1110             


Lys Lys  Glu Gly Ala Phe Ser  Asn Ile Ser Lys Tyr  Gly Gly Tyr 
    1115                 1120                 1125             


Asn Lys  Val Ser Ala Ala Tyr  Tyr Thr Leu Ile Glu  Tyr Glu Glu 
    1130                 1135                 1140             


Lys Gly  Asn Lys Ile Arg Ser  Leu Glu Thr Ile Pro  Leu Tyr Leu 
    1145                 1150                 1155             


Val Lys  Asp Ile Gln Lys Asp  Gln Asp Val Leu Lys  Ser Tyr Leu 
    1160                 1165                 1170             


Thr Asp  Leu Leu Gly Lys Lys  Glu Ile Lys Ile Leu  Val Pro Lys 
    1175                 1180                 1185             


Ile Lys  Ile Asn Ser Leu Leu  Lys Ile Asn Gly Phe  Pro Cys His 
    1190                 1195                 1200             


Ile Thr  Gly Lys Thr Gly Asp  Ser Phe Val Leu Arg  Pro Ala Val 
    1205                 1210                 1215             


Gln Phe  Cys Cys Ser Asn Asp  Glu Val Leu Tyr Phe  Lys Lys Ile 
    1220                 1225                 1230             


Ile Arg  Phe Asn Glu Ile Arg  Ser Gln Arg Glu Lys  Met Gly Lys 
    1235                 1240                 1245             


Thr Ile  Ser Pro Tyr Glu Asp  Leu Ser Phe Arg Ser  Tyr Ile Lys 
    1250                 1255                 1260             


Glu Asn  Leu Cys Lys Lys Thr  Lys Ala Asp Glu Ile  Gly Glu Lys 
    1265                 1270                 1275             


Glu Phe  Tyr Asp Leu Leu Gln  Lys Lys Asn Leu Glu  Ile Tyr Asp 
    1280                 1285                 1290             


Met Leu  Leu Thr Lys His Lys  Asp Thr Ile Tyr Asn  Lys Arg Pro 
    1295                 1300                 1305             


Asn Ser  Thr Thr Leu Gly Met  Leu Thr Lys Gly Arg  Tyr Glu Phe 
    1310                 1315                 1320             


Ile Asn  Leu Lys Pro Lys Asp  Gln Ile Ile Val Met  Leu Glu Ile 
    1325                 1330                 1335             


Leu Lys  Leu Phe Cys Thr Thr  Arg Glu Ala Ile Asp  Leu Gly Leu 
    1340                 1345                 1350             


Ile Lys  Gly Lys Pro Ala Ala  Gly Val Ala Thr Leu  Gly Lys Lys 
    1355                 1360                 1365             


Ile Ser  Asn Pro Asp Asn Cys  Ile Leu Ile Tyr Gln  Ser Ile Thr 
    1370                 1375                 1380             


Gly Ile  Phe Glu Lys Arg Ile  Asp Leu Leu Lys Val  
    1385                 1390                 1395 


<210> 607
<211> 1395
<212> PRT
<213> Treponema denticola


<220>
<223> Treponema denticola OTK

<400> 607
Met Lys Lys Glu Ile Lys Asp Tyr Phe Leu Gly Leu Asp Val Gly Thr 
1               5                   10                  15      


Gly Ser Val Gly Trp Ala Val Thr Asp Thr Asp Tyr Lys Leu Leu Lys 
            20                  25                  30          


Ala Asn Arg Lys Asp Leu Trp Gly Met Arg Cys Phe Glu Thr Ala Glu 
        35                  40                  45              


Thr Ala Glu Val Arg Arg Leu His Arg Gly Ala Arg Arg Arg Ile Glu 
    50                  55                  60                  


Arg Arg Lys Lys Arg Ile Lys Leu Leu Gln Glu Leu Phe Ser Gln Glu 
65                  70                  75                  80  


Ile Ala Lys Ile Asp Glu Gly Phe Phe Gln Arg Met Lys Glu Ser Pro 
                85                  90                  95      


Leu Tyr Ala Glu Asp Lys Thr Ile Leu Gln Glu Asn Thr Leu Phe Asn 
            100                 105                 110         


Asp Lys Asp Phe Thr Asp Lys Thr Tyr His Lys Ala Tyr Pro Thr Ile 
        115                 120                 125             


Asn His Leu Ile Lys Ala Trp Ile Glu Asn Lys Val Lys Pro Asp Pro 
    130                 135                 140                 


Arg Leu Leu Tyr Leu Ala Cys His Asn Ile Ile Lys Lys Arg Gly His 
145                 150                 155                 160 


Phe Leu Phe Glu Gly Asp Phe Asp Ser Glu Asn Gln Phe Asp Thr Ser 
                165                 170                 175     


Ile Gln Ala Leu Phe Glu Tyr Leu Arg Glu Asp Met Glu Leu Asp Ile 
            180                 185                 190         


Asp Ala Asp Ser Gln Lys Val Lys Glu Ile Leu Lys Asp Ser Ser Leu 
        195                 200                 205             


Lys Asn Ser Glu Lys Gln Ser Arg Leu Asn Lys Met Leu Gly Leu Lys 
    210                 215                 220                 


Pro Ser Asp Lys Gln Lys Lys Ala Ile Thr Asn Leu Ile Ser Gly Asn 
225                 230                 235                 240 


Lys Ile Asn Phe Ala Asp Leu Tyr Asp Asn Pro Asp Leu Lys Asp Ala 
                245                 250                 255     


Glu Lys Asn Ser Ile Ser Phe Ser Lys Asp Asp Phe Asp Ala Leu Ser 
            260                 265                 270         


Asp Asp Leu Ala Ser Ile Leu Gly Asp Ser Phe Glu Leu Leu Leu Lys 
        275                 280                 285             


Ala Lys Ala Val Tyr Asn Cys Ser Val Leu Ser Lys Val Ile Gly Asp 
    290                 295                 300                 


Glu Gln Tyr Leu Ser Phe Ala Lys Val Lys Ile Tyr Glu Lys His Lys 
305                 310                 315                 320 


Thr Asp Leu Thr Lys Leu Lys Asn Val Ile Lys Lys His Phe Pro Lys 
                325                 330                 335     


Asp Tyr Lys Lys Val Phe Gly Tyr Asn Lys Asn Glu Lys Asn Asn Asn 
            340                 345                 350         


Asn Tyr Ser Ala Tyr Val Gly Val Cys Lys Ile Thr His Lys Lys Leu 
        355                 360                 365             


Val Ile Lys Asn Ser Ala Ser Gln Glu Asp Phe Tyr Lys Phe Leu Lys 
    370                 375                 380                 


Thr Ile Leu Ser Ala Lys Ser Glu Ile Lys Glu Val Asn Asp Ile Leu 
385                 390                 395                 400 


Thr Glu Ile Glu Thr Gly Thr Phe Leu Pro Lys Gln Ile Ser Lys Ser 
                405                 410                 415     


Asn Ala Glu Ile Pro Tyr Gln Leu Arg Lys Met Glu Leu Glu Lys Ile 
            420                 425                 430         


Leu Ser Asn Ala Glu Lys His Phe Ser Phe Leu Lys Gln Lys Asp Glu 
        435                 440                 445             


Lys Gly Leu Ser His Ser Glu Lys Ile Ile Met Leu Leu Thr Phe Lys 
    450                 455                 460                 


Ile Pro Tyr Tyr Ile Gly Pro Ile Asn Asp Asn His Lys Lys Ser Phe 
465                 470                 475                 480 


Pro Asp Arg Cys Trp Val Val Lys Lys Glu Lys Ser Pro Ser Gly Lys 
                485                 490                 495     


Thr Thr Pro Trp Asn Phe Phe Asp His Ile Asp Lys Glu Lys Thr Ala 
            500                 505                 510         


Glu Glu Phe Ile Thr Ser Arg Thr Asn Phe Cys Thr Tyr Leu Ile Gly 
        515                 520                 525             


Glu Ser Val Leu Pro Lys Ser Ser Leu Leu Tyr Ser Glu Tyr Thr Val 
    530                 535                 540                 


Leu Asn Glu Ile Asn Asn Leu Gln Ile Ile Ile Asp Gly Lys Asn Ile 
545                 550                 555                 560 


Cys Asp Ile Lys Leu Lys Gln Lys Ile Tyr Glu Glu Leu Phe Lys Lys 
                565                 570                 575     


Tyr Lys Lys Ile Thr Gln Lys Gln Ile Ser Thr Phe Ile Lys His Glu 
            580                 585                 590         


Gly Ile Cys Asn Lys Thr Asp Glu Val Ile Ile Leu Gly Ile Asp Lys 
        595                 600                 605             


Glu Cys Thr Ser Ser Leu Lys Ser Tyr Ile Glu Leu Lys Asn Ile Phe 
    610                 615                 620                 


Gly Lys Gln Val Asp Glu Ile Ser Thr Lys Asn Met Leu Glu Glu Ile 
625                 630                 635                 640 


Ile Arg Trp Ala Thr Ile Tyr Asp Glu Gly Glu Gly Lys Thr Ile Leu 
                645                 650                 655     


Lys Thr Lys Ile Lys Ala Glu Tyr Gly Lys Tyr Cys Ser Asp Glu Gln 
            660                 665                 670         


Ile Lys Lys Ile Leu Asn Leu Lys Phe Ser Gly Trp Gly Arg Leu Ser 
        675                 680                 685             


Arg Lys Phe Leu Glu Thr Val Thr Ser Glu Met Pro Gly Phe Ser Glu 
    690                 695                 700                 


Pro Val Asn Ile Ile Thr Ala Met Arg Glu Thr Gln Asn Asn Leu Met 
705                 710                 715                 720 


Glu Leu Leu Ser Ser Glu Phe Lys Phe Thr Glu Asn Ile Lys Lys Ile 
                725                 730                 735     


Asn Ser Gly Phe Glu Asp Ala Glu Lys Gln Phe Ser Tyr Asn Gly Leu 
            740                 745                 750         


Val Lys Pro Leu Phe Leu Ser Pro Ser Val Lys Lys Met Leu Trp Gln 
        755                 760                 765             


Thr Leu Lys Leu Val Lys Glu Ile Ser His Ile Thr Gln Ala Pro Pro 
    770                 775                 780                 


Lys Lys Ile Phe Ile Glu Met Ala Lys Gly Ala Glu Leu Glu Pro Ala 
785                 790                 795                 800 


Arg Thr Lys Thr Arg Leu Lys Ile Leu Gln Asp Leu Tyr Ser Ser Cys 
                805                 810                 815     


Lys Asn Asp Ala Asp Ala Phe Ser Ser Glu Ile Gln Tyr Leu Ser Gly 
            820                 825                 830         


Lys Ile Glu Asn Glu Asp Asn Leu Arg Leu Arg Ser Asp Lys Leu Tyr 
        835                 840                 845             


Leu Tyr Tyr Thr Gln Leu Gly Lys Cys Met Tyr Cys Gly Lys Pro Ile 
    850                 855                 860                 


Glu Ile Gly His Val Phe Asp Thr Ser Asn Tyr Asp Ile Asp His Ile 
865                 870                 875                 880 


Tyr Pro Gln Ser Lys Ile Lys Asp Asp Ser Ile Ser Asn Arg Val Leu 
                885                 890                 895     


Val Cys Ser Ser Cys Asn Lys Asn Lys Glu Asp Lys Tyr Pro Leu Lys 
            900                 905                 910         


Ala Glu Ile Gln Ser Lys Gln Arg Gly Phe Trp Asn Phe Leu Gln Arg 
        915                 920                 925             


Asn Asn Phe Ile Ser Leu Glu Lys Leu Asn Arg Leu Thr Arg Thr Ser 
    930                 935                 940                 


Pro Ile Ser Asp Asp Glu Thr Ala Lys Phe Ile Ala Arg Gln Leu Val 
945                 950                 955                 960 


Glu Thr Arg Gln Ala Thr Lys Val Ala Ala Lys Val Leu Glu Lys Met 
                965                 970                 975     


Phe Pro Glu Thr Lys Ile Val Tyr Ser Lys Ala Glu Thr Val Ser Met 
            980                 985                 990         


Phe Arg Asn Lys Phe Asp Ile Ile  Lys Cys Arg Glu Ile  Asn Asp Phe 
        995                 1000                 1005             


His His  Ala His Asp Ala Tyr  Leu Asn Ile Val Val  Gly Asn Val 
    1010                 1015                 1020             


Tyr Asn  Thr Lys Phe Thr Asn  Asn Pro Trp Asn Phe  Ile Lys Glu 
    1025                 1030                 1035             


Lys Arg  Asp Asn Pro Lys Ile  Ala Asp Thr Tyr Asn  Tyr Tyr Lys 
    1040                 1045                 1050             


Val Phe  Asp Tyr Asp Val Lys  Arg Asn Asn Ile Thr  Ala Trp Glu 
    1055                 1060                 1065             


Lys Gly  Lys Thr Ile Ile Thr  Val Lys Asp Met Leu  Lys Arg Asn 
    1070                 1075                 1080             


Thr Pro  Ile Tyr Thr Arg Gln  Ala Ala Cys Lys Lys  Gly Glu Leu 
    1085                 1090                 1095             


Phe Asn  Gln Thr Ile Met Lys  Lys Gly Leu Gly Gln  His Pro Leu 
    1100                 1105                 1110             


Lys Lys  Glu Gly Pro Leu Ser  Asn Ile Ser Lys Tyr  Gly Gly Tyr 
    1115                 1120                 1125             


Asn Lys  Val Ser Ala Ala Tyr  Tyr Thr Leu Ile Glu  Tyr Glu Glu 
    1130                 1135                 1140             


Lys Gly  Ser Lys Ile Arg Ser  Leu Glu Thr Ile Pro  Leu Tyr Leu 
    1145                 1150                 1155             


Val Lys  Asp Ile Gln Lys Asn  Lys Asp Gly Leu Lys  Ser Tyr Leu 
    1160                 1165                 1170             


Thr Asp  Gln Ile Gly Lys Lys  Glu Ile Lys Ile Leu  Ile Pro Lys 
    1175                 1180                 1185             


Ile Lys  Ile Asn Ser Leu Leu  Lys Ile Asn Gly Phe  Pro Cys His 
    1190                 1195                 1200             


Ile Thr  Gly Lys Met Gly Glu  Ala Phe Val Leu Arg  Pro Ala Val 
    1205                 1210                 1215             


Gln Phe  Cys Cys Ser Asn Asp  Glu Ala Leu Tyr Phe  Lys Lys Ile 
    1220                 1225                 1230             


Ile Arg  Phe Asn Glu Ile Arg  Lys Gln Arg Glu Lys  Met Gly Lys 
    1235                 1240                 1245             


Thr Ile  Ser Pro Tyr Glu Asp  Leu Ser Phe Arg Ser  Tyr Ile Lys 
    1250                 1255                 1260             


Asp Asn  Leu Cys Lys Lys Thr  Lys Ala Asp Glu Ile  Glu Glu Lys 
    1265                 1270                 1275             


Glu Phe  Tyr Asp Leu Leu Gln  Lys Lys Asn Leu Glu  Ile Tyr Asp 
    1280                 1285                 1290             


Met Leu  Leu Thr Lys His Lys  Asp Thr Ile Tyr Lys  Lys Arg Pro 
    1295                 1300                 1305             


Asn Ser  Ala Thr Ile Asp Ile  Leu Val Lys Gly Lys  Glu Lys Phe 
    1310                 1315                 1320             


Lys Ser  Leu Ile Ile Glu Asn  Gln Phe Glu Val Ile  Leu Glu Ile 
    1325                 1330                 1335             


Leu Lys  Leu Phe Ser Ala Thr  Arg Asn Val Ser Asp  Leu Gln His 
    1340                 1345                 1350             


Ile Gly  Gly Ser Lys Asn Ala  Gly Asn Ala Arg Val  Gly Asn Lys 
    1355                 1360                 1365             


Ile Ser  Ser Leu Asp Asn Cys  Ile Leu Ile Tyr Gln  Ser Ile Thr 
    1370                 1375                 1380             


Gly Ile  Phe Glu Lys Arg Ile  Asp Leu Leu Lys Ile  
    1385                 1390                 1395 


<210> 608
<211> 1395
<212> PRT
<213> Treponema denticola


<220>
<223> Treponema denticola SP37

<400> 608
Met Lys Lys Glu Ile Lys Asp Tyr Phe Leu Gly Leu Asp Val Gly Thr 
1               5                   10                  15      


Gly Ser Val Gly Trp Ala Val Thr Asp Thr Asp Tyr Lys Leu Leu Lys 
            20                  25                  30          


Ala Asn Arg Lys Asp Leu Trp Gly Met Arg Cys Phe Glu Thr Ala Glu 
        35                  40                  45              


Thr Ala Glu Val Arg Arg Leu His Arg Gly Ala Arg Arg Arg Ile Glu 
    50                  55                  60                  


Arg Arg Lys Lys Arg Ile Lys Leu Leu Gln Glu Leu Phe Ser Gln Glu 
65                  70                  75                  80  


Ile Ala Lys Thr Asp Glu Gly Phe Phe Gln Arg Met Lys Glu Ser Pro 
                85                  90                  95      


Phe Tyr Ala Glu Asp Lys Thr Ile Leu Gln Glu Asn Ala Leu Phe Asn 
            100                 105                 110         


Asp Arg Asp Phe Thr Asp Lys Thr Tyr His Lys Ala Tyr Pro Thr Ile 
        115                 120                 125             


Asn His Leu Ile Lys Ala Trp Ile Glu Asn Lys Val Lys Pro Asp Pro 
    130                 135                 140                 


Arg Leu Leu Tyr Leu Ala Cys His Asn Ile Ile Lys Lys Arg Gly His 
145                 150                 155                 160 


Phe Leu Phe Glu Gly Asp Phe Asp Ser Glu Asn Gln Phe Asp Thr Ser 
                165                 170                 175     


Ile Gln Ala Leu Phe Glu Tyr Leu Arg Glu Asp Met Glu Val Asp Ile 
            180                 185                 190         


Asp Ala Asp Ser Gln Lys Val Lys Glu Ile Leu Lys Asp Ser Ser Leu 
        195                 200                 205             


Lys Asn Ser Glu Lys Gln Ser Arg Leu Asn Lys Met Leu Gly Leu Lys 
    210                 215                 220                 


Pro Ser Asp Lys Gln Lys Lys Ala Ile Thr Asn Leu Ile Ser Gly Asn 
225                 230                 235                 240 


Lys Ile Asn Phe Ala Asp Leu Tyr Asp Asn Pro Asp Leu Lys Asp Ala 
                245                 250                 255     


Glu Lys Asn Ser Ile Ser Phe Ser Lys Asp Asp Phe Asp Ala Leu Ser 
            260                 265                 270         


Asp Asp Leu Ala Ser Ile Leu Gly Asp Ser Phe Glu Leu Leu Leu Lys 
        275                 280                 285             


Ala Lys Ala Val Tyr Asn Cys Ser Val Leu Ser Lys Val Ile Gly Asp 
    290                 295                 300                 


Glu Gln Tyr Leu Ser Phe Ala Lys Val Lys Ile Tyr Glu Lys His Lys 
305                 310                 315                 320 


Thr Asp Leu Thr Lys Leu Lys Asn Val Ile Lys Lys His Phe Pro Asn 
                325                 330                 335     


Asp Tyr Lys Lys Val Phe Gly Tyr Asn Lys Asn Glu Lys Asn Asn Asn 
            340                 345                 350         


Asn Tyr Ser Ala Tyr Val Gly Val Cys Lys Thr Lys Ser Lys Lys Leu 
        355                 360                 365             


Val Ile Asn Asn Thr Val Asn Gln Glu Asp Phe Tyr Lys Phe Leu Lys 
    370                 375                 380                 


Pro Ile Leu Leu Ala Lys Ser Glu Ile Lys Glu Val Asn Asp Ile Leu 
385                 390                 395                 400 


Thr Glu Ile Glu Thr Gly Thr Phe Leu Pro Lys Gln Ile Ser Lys Ser 
                405                 410                 415     


Asn Ala Glu Ile Pro Tyr Gln Leu Arg Lys Met Glu Leu Glu Lys Ile 
            420                 425                 430         


Leu Ser Asn Ala Glu Lys His Phe Ser Phe Leu Lys Gln Lys Asp Glu 
        435                 440                 445             


Lys Gly Leu Ser His Ser Glu Lys Ile Ile Met Leu Leu Thr Phe Lys 
    450                 455                 460                 


Ile Pro Tyr Tyr Ile Gly Pro Ile Asn Asp Asn His Lys Lys Ser Phe 
465                 470                 475                 480 


Pro Asp Arg Cys Trp Val Ile Lys Lys Glu Lys Ser Pro Ser Gly Lys 
                485                 490                 495     


Thr Thr Pro Trp Asn Phe Phe Asp His Ile Asp Lys Asp Lys Thr Ala 
            500                 505                 510         


Glu Ala Phe Ile Thr Ser Arg Thr Asn Phe Cys Thr Tyr Leu Val Gly 
        515                 520                 525             


Glu Ser Val Leu Pro Lys Asn Ser Leu Leu Tyr Ser Glu Tyr Thr Val 
    530                 535                 540                 


Leu Asn Glu Ile Asn Asn Leu Gln Ile Ile Ile Asp Gly Lys Asn Ile 
545                 550                 555                 560 


Cys Asp Ile Lys Leu Lys Gln Lys Ile Tyr Glu Glu Leu Phe Lys Lys 
                565                 570                 575     


Tyr Lys Lys Ile Thr Gln Lys Gln Ile Ser Thr Phe Ile Lys His Glu 
            580                 585                 590         


Gly Ile Cys Asn Lys Thr Asp Glu Val Ile Ile Leu Gly Ile Asp Lys 
        595                 600                 605             


Glu Cys Thr Ser Ser Leu Lys Ser Tyr Ile Glu Leu Lys Asn Ile Phe 
    610                 615                 620                 


Gly Lys Gln Val Asp Glu Ile Ser Thr Lys Asn Met Leu Glu Glu Ile 
625                 630                 635                 640 


Ile Arg Trp Ala Thr Ile Tyr Asp Glu Gly Glu Gly Lys Thr Ile Leu 
                645                 650                 655     


Lys Thr Lys Ile Lys Ala Glu Tyr Gly Lys Tyr Cys Ser Asp Glu Gln 
            660                 665                 670         


Ile Lys Lys Ile Leu Asn Leu Lys Phe Ser Gly Trp Gly Arg Leu Ser 
        675                 680                 685             


Arg Lys Phe Leu Glu Thr Val Thr Ser Glu Met Pro Gly Phe Ser Glu 
    690                 695                 700                 


Pro Val Asn Ile Ile Thr Ala Met Arg Glu Thr Gln Asn Asn Leu Met 
705                 710                 715                 720 


Glu Leu Leu Ser Ser Glu Phe Lys Phe Thr Glu Asn Ile Lys Lys Ile 
                725                 730                 735     


Asn Ser Gly Phe Glu Asp Val Glu Lys Gln Phe Ser Tyr Asp Ser Leu 
            740                 745                 750         


Val Lys Pro Leu Phe Leu Ser Pro Ser Val Lys Lys Met Leu Trp Gln 
        755                 760                 765             


Thr Leu Lys Leu Val Lys Glu Ile Ser His Ile Thr Gln Ala Pro Pro 
    770                 775                 780                 


Lys Lys Ile Phe Ile Glu Met Ala Lys Gly Ala Glu Leu Asp Pro Val 
785                 790                 795                 800 


Arg Thr Lys Thr Arg Leu Lys Ile Leu Gln Asp Leu Tyr Asn Asn Cys 
                805                 810                 815     


Lys Asn Asp Ala Asp Ala Phe Ser Ser Glu Ile Lys Asp Leu Ser Gly 
            820                 825                 830         


Lys Ile Glu Asn Glu Asp Asn Leu Arg Leu Arg Ser Asp Lys Leu Tyr 
        835                 840                 845             


Leu Tyr Tyr Thr Gln Leu Gly Lys Cys Met Tyr Cys Gly Lys Pro Ile 
    850                 855                 860                 


Glu Ile Gly His Val Phe Asp Thr Ser Asn Tyr Asp Ile Asp His Ile 
865                 870                 875                 880 


Tyr Pro Gln Ser Lys Ile Lys Asp Asp Ser Ile Ser Asn Arg Val Leu 
                885                 890                 895     


Val Cys Ser Ser Cys Asn Lys Asn Lys Glu Asp Lys Tyr Pro Leu Lys 
            900                 905                 910         


Ala Glu Ile Gln Ser Lys Gln Arg Gly Phe Trp Asn Phe Leu Gln Arg 
        915                 920                 925             


Asn Asn Phe Ile Ser Leu Glu Lys Leu Asn Arg Leu Thr Arg Thr Ser 
    930                 935                 940                 


Pro Ile Ser Asp Asp Glu Thr Ala Lys Phe Ile Ala Arg Gln Leu Val 
945                 950                 955                 960 


Glu Thr Arg Gln Ala Thr Lys Val Ala Ala Lys Val Leu Glu Lys Met 
                965                 970                 975     


Phe Pro Glu Thr Lys Ile Val Tyr Ser Lys Ala Glu Thr Val Ser Met 
            980                 985                 990         


Phe Arg Asn Lys Phe Asp Ile Ile  Lys Cys Arg Glu Ile  Asn Asp Phe 
        995                 1000                 1005             


His His  Ala His Asp Ala Tyr  Leu Asn Ile Val Val  Gly Asn Val 
    1010                 1015                 1020             


Tyr Asn  Thr Lys Phe Thr Asn  Asn Pro Trp Asn Phe  Ile Lys Glu 
    1025                 1030                 1035             


Lys Arg  Asp Asn Pro Lys Ile  Ala Asp Thr Tyr Asn  Tyr Tyr Lys 
    1040                 1045                 1050             


Val Phe  Asp Tyr Asp Val Lys  Arg Asn Asn Ile Thr  Ala Trp Glu 
    1055                 1060                 1065             


Lys Gly  Lys Thr Ile Ile Thr  Val Lys Asp Met Leu  Lys Arg Asn 
    1070                 1075                 1080             


Thr Pro  Ile Tyr Thr Arg Gln  Ala Ala Cys Lys Lys  Gly Glu Leu 
    1085                 1090                 1095             


Phe Asn  Gln Thr Ile Met Lys  Lys Gly Leu Gly Gln  His Pro Leu 
    1100                 1105                 1110             


Lys Lys  Glu Gly Pro Leu Ser  Asn Ile Ser Lys Tyr  Gly Gly Tyr 
    1115                 1120                 1125             


Asn Lys  Val Ser Ala Ala Tyr  Tyr Thr Leu Ile Glu  Tyr Glu Glu 
    1130                 1135                 1140             


Lys Gly  Ser Lys Ile Arg Ser  Leu Glu Thr Ile Pro  Leu Tyr Leu 
    1145                 1150                 1155             


Val Lys  Asp Ile Gln Lys Asn  Lys Asp Gly Leu Lys  Ser Tyr Leu 
    1160                 1165                 1170             


Thr Asp  Gln Ile Gly Lys Lys  Glu Ile Lys Ile Leu  Ile Pro Lys 
    1175                 1180                 1185             


Ile Lys  Ile Asn Ser Leu Leu  Lys Ile Asn Gly Phe  Pro Cys His 
    1190                 1195                 1200             


Ile Thr  Gly Lys Met Gly Glu  Ala Phe Val Leu Arg  Pro Ala Val 
    1205                 1210                 1215             


Gln Phe  Cys Cys Ser Asn Asp  Glu Ala Leu Tyr Phe  Lys Lys Ile 
    1220                 1225                 1230             


Ile Arg  Phe Asn Glu Ile Arg  Lys Gln Arg Glu Lys  Met Gly Lys 
    1235                 1240                 1245             


Thr Ile  Ser Pro Tyr Glu Asp  Leu Ser Phe Arg Ser  Tyr Ile Lys 
    1250                 1255                 1260             


Asp Asn  Leu Cys Lys Lys Thr  Lys Ala Asp Glu Ile  Glu Glu Lys 
    1265                 1270                 1275             


Glu Phe  Tyr Asp Leu Leu Gln  Lys Lys Asn Leu Glu  Ile Tyr Asp 
    1280                 1285                 1290             


Met Leu  Leu Thr Lys His Lys  Asp Thr Ile Tyr Lys  Lys Arg Pro 
    1295                 1300                 1305             


Asn Ser  Ala Thr Ile Asp Ile  Leu Val Lys Gly Lys  Glu Lys Phe 
    1310                 1315                 1320             


Lys Ser  Leu Ile Ile Glu Asn  Gln Phe Glu Val Ile  Leu Glu Ile 
    1325                 1330                 1335             


Leu Lys  Leu Phe Ser Ala Thr  Arg Asn Val Ser Asp  Leu Gln His 
    1340                 1345                 1350             


Ile Gly  Gly Ser Lys Asn Ala  Gly Asn Ala Arg Val  Gly Asn Lys 
    1355                 1360                 1365             


Ile Ser  Ser Leu Asp Asn Cys  Ile Leu Ile Tyr Gln  Ser Ile Thr 
    1370                 1375                 1380             


Gly Ile  Phe Glu Lys Arg Ile  Asp Leu Leu Lys Ile  
    1385                 1390                 1395 


<210> 609
<211> 1062
<212> PRT
<213> Treponema sp.


<220>
<223> Treponema sp. JC4

<400> 609
Met Ile Met Lys Leu Glu Lys Trp Arg Leu Gly Leu Asp Leu Gly Thr 
1               5                   10                  15      


Asn Ser Ile Gly Trp Ser Val Phe Ser Leu Asp Lys Asp Asn Ser Val 
            20                  25                  30          


Gln Asp Leu Ile Asp Met Gly Val Arg Ile Phe Ser Asp Gly Arg Asp 
        35                  40                  45              


Pro Lys Thr Lys Glu Pro Leu Ala Val Ala Arg Arg Thr Ala Arg Ser 
    50                  55                  60                  


Gln Arg Lys Leu Ile Tyr Arg Arg Lys Leu Arg Arg Lys Gln Val Phe 
65                  70                  75                  80  


Lys Phe Leu Gln Glu Gln Gly Leu Phe Pro Lys Thr Lys Glu Glu Cys 
                85                  90                  95      


Met Thr Leu Lys Ser Leu Asn Pro Tyr Glu Leu Arg Ile Lys Ala Leu 
            100                 105                 110         


Asp Glu Lys Leu Glu Pro Tyr Glu Leu Gly Arg Ala Leu Phe Asn Leu 
        115                 120                 125             


Ala Val Arg Arg Gly Phe Lys Ser Asn Arg Lys Asp Gly Ser Arg Glu 
    130                 135                 140                 


Glu Val Ser Glu Lys Lys Ser Pro Asp Glu Ile Lys Thr Gln Ala Asp 
145                 150                 155                 160 


Met Gln Thr His Leu Glu Lys Ala Ile Lys Glu Asn Gly Cys Arg Thr 
                165                 170                 175     


Ile Thr Glu Phe Leu Tyr Lys Asn Gln Gly Glu Asn Gly Gly Ile Arg 
            180                 185                 190         


Phe Ala Pro Gly Arg Met Thr Tyr Tyr Pro Thr Arg Lys Met Tyr Glu 
        195                 200                 205             


Glu Glu Phe Asn Leu Ile Arg Ser Lys Gln Glu Lys Tyr Tyr Pro Gln 
    210                 215                 220                 


Val Asp Trp Asp Asp Ile Tyr Lys Ala Ile Phe Tyr Gln Arg Pro Leu 
225                 230                 235                 240 


Lys Pro Gln Gln Arg Gly Tyr Cys Ile Tyr Glu Asn Asp Lys Glu Arg 
                245                 250                 255     


Thr Phe Lys Ala Met Pro Cys Ser Gln Lys Leu Arg Ile Leu Gln Asp 
            260                 265                 270         


Ile Gly Asn Leu Ala Tyr Tyr Glu Gly Gly Ser Lys Lys Arg Val Glu 
        275                 280                 285             


Leu Asn Asp Asn Gln Asp Lys Val Leu Tyr Glu Leu Leu Asn Ser Lys 
    290                 295                 300                 


Asp Lys Val Thr Phe Asp Gln Met Arg Lys Ala Leu Cys Leu Ala Asp 
305                 310                 315                 320 


Ser Asn Ser Phe Asn Leu Glu Glu Asn Arg Asp Phe Leu Ile Gly Asn 
                325                 330                 335     


Pro Thr Ala Val Lys Met Arg Ser Lys Asn Arg Phe Gly Lys Leu Trp 
            340                 345                 350         


Asp Glu Ile Pro Leu Glu Glu Gln Asp Leu Ile Ile Glu Thr Ile Ile 
        355                 360                 365             


Thr Ala Asp Glu Asp Asp Ala Val Tyr Glu Val Ile Lys Lys Tyr Asp 
    370                 375                 380                 


Leu Thr Gln Glu Gln Arg Asp Phe Ile Val Lys Asn Thr Ile Leu Gln 
385                 390                 395                 400 


Ser Gly Thr Ser Met Leu Cys Lys Glu Val Ser Glu Lys Leu Val Lys 
                405                 410                 415     


Arg Leu Glu Glu Ile Ala Asp Leu Lys Tyr His Glu Ala Val Glu Ser 
            420                 425                 430         


Leu Gly Tyr Lys Phe Ala Asp Gln Thr Val Glu Lys Tyr Asp Leu Leu 
        435                 440                 445             


Pro Tyr Tyr Gly Lys Val Leu Pro Gly Ser Thr Met Glu Ile Asp Leu 
    450                 455                 460                 


Ser Ala Pro Glu Thr Asn Pro Glu Lys His Tyr Gly Lys Ile Ser Asn 
465                 470                 475                 480 


Pro Thr Val His Val Ala Leu Asn Gln Thr Arg Val Val Val Asn Ala 
                485                 490                 495     


Leu Ile Lys Glu Tyr Gly Lys Pro Ser Gln Ile Ala Ile Glu Leu Ser 
            500                 505                 510         


Arg Asp Leu Lys Asn Asn Val Glu Lys Lys Ala Glu Ile Ala Arg Lys 
        515                 520                 525             


Gln Asn Gln Arg Ala Lys Glu Asn Ile Ala Ile Asn Asp Thr Ile Ser 
    530                 535                 540                 


Ala Leu Tyr His Thr Ala Phe Pro Gly Lys Ser Phe Tyr Pro Asn Arg 
545                 550                 555                 560 


Asn Asp Arg Met Lys Tyr Arg Leu Trp Ser Glu Leu Gly Leu Gly Asn 
                565                 570                 575     


Lys Cys Ile Tyr Cys Gly Lys Gly Ile Ser Gly Ala Glu Leu Phe Thr 
            580                 585                 590         


Lys Glu Ile Glu Ile Glu His Ile Leu Pro Phe Ser Arg Thr Leu Leu 
        595                 600                 605             


Asp Ala Glu Ser Asn Leu Thr Val Ala His Ser Ser Cys Asn Ala Phe 
    610                 615                 620                 


Lys Ala Glu Arg Ser Pro Phe Glu Ala Phe Gly Thr Asn Pro Ser Gly 
625                 630                 635                 640 


Tyr Ser Trp Gln Glu Ile Ile Gln Arg Ala Asn Gln Leu Lys Asn Thr 
                645                 650                 655     


Ser Lys Lys Asn Lys Phe Ser Pro Asn Ala Met Asp Ser Phe Glu Lys 
            660                 665                 670         


Asp Ser Ser Phe Ile Ala Arg Gln Leu Ser Asp Asn Gln Tyr Ile Ala 
        675                 680                 685             


Lys Ala Ala Leu Arg Tyr Leu Lys Cys Leu Val Glu Asn Pro Ser Asp 
    690                 695                 700                 


Val Trp Thr Thr Asn Gly Ser Met Thr Lys Leu Leu Arg Asp Lys Trp 
705                 710                 715                 720 


Glu Met Asp Ser Ile Leu Cys Arg Lys Phe Thr Glu Lys Glu Val Ala 
                725                 730                 735     


Leu Leu Gly Leu Lys Pro Glu Gln Ile Gly Asn Tyr Lys Lys Asn Arg 
            740                 745                 750         


Phe Asp His Arg His His Ala Ile Asp Ala Val Val Ile Gly Leu Thr 
        755                 760                 765             


Asp Arg Ser Met Val Gln Lys Leu Ala Thr Lys Asn Ser His Lys Gly 
    770                 775                 780                 


Asn Arg Ile Glu Ile Pro Glu Phe Pro Ile Leu Arg Ser Asp Leu Ile 
785                 790                 795                 800 


Glu Lys Val Lys Asn Ile Val Val Ser Phe Lys Pro Asp His Gly Ala 
                805                 810                 815     


Glu Gly Lys Leu Ser Lys Glu Thr Leu Leu Gly Lys Ile Lys Leu His 
            820                 825                 830         


Gly Lys Glu Thr Phe Val Cys Arg Glu Asn Ile Val Ser Leu Ser Glu 
        835                 840                 845             


Lys Asn Leu Asp Asp Ile Val Asp Glu Lys Ile Lys Ser Lys Val Lys 
    850                 855                 860                 


Asp Tyr Val Ala Lys His Lys Gly Gln Lys Ile Glu Ala Val Leu Ser 
865                 870                 875                 880 


Asp Phe Ser Lys Glu Asn Gly Ile Lys Lys Val Arg Cys Val Asn Arg 
                885                 890                 895     


Val Gln Thr Pro Ile Glu Ile Thr Ser Gly Lys Ile Ser Arg Tyr Leu 
            900                 905                 910         


Ser Pro Glu Asp Tyr Phe Ala Ala Val Ile Trp Glu Ile Pro Gly Glu 
        915                 920                 925             


Lys Lys Thr Phe Lys Ala Gln Tyr Ile Arg Arg Asn Glu Val Glu Lys 
    930                 935                 940                 


Asn Ser Lys Gly Leu Asn Val Val Lys Pro Ala Val Leu Glu Asn Gly 
945                 950                 955                 960 


Lys Pro His Pro Ala Ala Lys Gln Val Cys Leu Leu His Lys Asp Asp 
                965                 970                 975     


Tyr Leu Glu Phe Ser Asp Lys Gly Lys Met Tyr Phe Cys Arg Ile Ala 
            980                 985                 990         


Gly Tyr Ala Ala Thr Asn Asn Lys  Leu Asp Ile Arg Pro  Val Tyr Ala 
        995                 1000                 1005             


Val Ser  Tyr Cys Ala Asp Trp  Ile Asn Ser Thr Asn  Glu Thr Met 
    1010                 1015                 1020             


Leu Thr  Gly Tyr Trp Lys Pro  Thr Pro Thr Gln Asn  Trp Val Ser 
    1025                 1030                 1035             


Val Asn  Val Leu Phe Asp Lys  Gln Lys Ala Arg Leu  Val Thr Val 
    1040                 1045                 1050             


Ser Pro  Ile Gly Arg Val Phe  Arg Lys 
    1055                 1060         


<210> 610
<211> 1011
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      uncultured delta proteobacterium HF0070_07E19 polypeptide

<400> 610
Met Ser Ser Lys Ala Ile Asp Ser Leu Glu Gln Leu Asp Leu Phe Lys 
1               5                   10                  15      


Pro Gln Glu Tyr Thr Leu Gly Leu Asp Leu Gly Ile Lys Ser Ile Gly 
            20                  25                  30          


Trp Ala Ile Leu Ser Gly Glu Arg Ile Ala Asn Ala Gly Val Tyr Leu 
        35                  40                  45              


Phe Glu Thr Ala Glu Glu Leu Asn Ser Thr Gly Asn Lys Leu Ile Ser 
    50                  55                  60                  


Lys Ala Ala Glu Arg Gly Arg Lys Arg Arg Ile Arg Arg Met Leu Asp 
65                  70                  75                  80  


Arg Lys Ala Arg Arg Gly Arg His Ile Arg Tyr Leu Leu Glu Arg Glu 
                85                  90                  95      


Gly Leu Pro Thr Asp Glu Leu Glu Glu Val Val Val His Gln Ser Asn 
            100                 105                 110         


Arg Thr Leu Trp Asp Val Arg Ala Glu Ala Val Glu Arg Lys Leu Thr 
        115                 120                 125             


Lys Gln Glu Leu Ala Ala Val Leu Phe His Leu Val Arg His Arg Gly 
    130                 135                 140                 


Tyr Phe Pro Asn Thr Lys Lys Leu Pro Pro Asp Asp Glu Ser Asp Ser 
145                 150                 155                 160 


Ala Asp Glu Glu Gln Gly Lys Ile Asn Arg Ala Thr Ser Arg Leu Arg 
                165                 170                 175     


Glu Glu Leu Lys Ala Ser Asp Cys Lys Thr Ile Gly Gln Phe Leu Ala 
            180                 185                 190         


Gln Asn Arg Asp Arg Gln Arg Asn Arg Glu Gly Asp Tyr Ser Asn Leu 
        195                 200                 205             


Met Ala Arg Lys Leu Val Phe Glu Glu Ala Leu Gln Ile Leu Ala Phe 
    210                 215                 220                 


Gln Arg Lys Gln Gly His Glu Leu Ser Lys Asp Phe Glu Lys Thr Tyr 
225                 230                 235                 240 


Leu Asp Val Leu Met Gly Gln Arg Ser Gly Arg Ser Pro Lys Leu Gly 
                245                 250                 255     


Asn Cys Ser Leu Ile Pro Ser Glu Leu Arg Ala Pro Ser Ser Ala Pro 
            260                 265                 270         


Ser Thr Glu Trp Phe Lys Phe Leu Gln Asn Leu Gly Asn Leu Gln Ile 
        275                 280                 285             


Ser Asn Ala Tyr Arg Glu Glu Trp Ser Ile Asp Ala Pro Arg Arg Ala 
    290                 295                 300                 


Gln Ile Ile Asp Ala Cys Ser Gln Arg Ser Thr Ser Ser Tyr Trp Gln 
305                 310                 315                 320 


Ile Arg Arg Asp Phe Gln Ile Pro Asp Glu Tyr Arg Phe Asn Leu Val 
                325                 330                 335     


Asn Tyr Glu Arg Arg Asp Pro Asp Val Asp Leu Gln Glu Tyr Leu Gln 
            340                 345                 350         


Gln Gln Glu Arg Lys Thr Leu Ala Asn Phe Arg Asn Trp Lys Gln Leu 
        355                 360                 365             


Glu Lys Ile Ile Gly Thr Gly His Pro Ile Gln Thr Leu Asp Glu Ala 
    370                 375                 380                 


Ala Arg Leu Ile Thr Leu Ile Lys Asp Asp Glu Lys Leu Ser Asp Gln 
385                 390                 395                 400 


Leu Ala Asp Leu Leu Pro Glu Ala Ser Asp Lys Ala Ile Thr Gln Leu 
                405                 410                 415     


Cys Glu Leu Asp Phe Thr Thr Ala Ala Lys Ile Ser Leu Glu Ala Met 
            420                 425                 430         


Tyr Arg Ile Leu Pro His Met Asn Gln Gly Met Gly Phe Phe Asp Ala 
        435                 440                 445             


Cys Gln Gln Glu Ser Leu Pro Glu Ile Gly Val Pro Pro Ala Gly Asp 
    450                 455                 460                 


Arg Val Pro Pro Phe Asp Glu Met Tyr Asn Pro Val Val Asn Arg Val 
465                 470                 475                 480 


Leu Ser Gln Ser Arg Lys Leu Ile Asn Ala Val Ile Asp Glu Tyr Gly 
                485                 490                 495     


Met Pro Ala Lys Ile Arg Val Glu Leu Ala Arg Asp Leu Gly Lys Gly 
            500                 505                 510         


Arg Glu Leu Arg Glu Arg Ile Lys Leu Asp Gln Leu Asp Lys Ser Lys 
        515                 520                 525             


Gln Asn Asp Gln Arg Ala Glu Asp Phe Arg Ala Glu Phe Gln Gln Ala 
    530                 535                 540                 


Pro Arg Gly Asp Gln Ser Leu Arg Tyr Arg Leu Trp Lys Glu Gln Asn 
545                 550                 555                 560 


Cys Thr Cys Pro Tyr Ser Gly Arg Met Ile Pro Val Asn Ser Val Leu 
                565                 570                 575     


Ser Glu Asp Thr Gln Ile Asp His Ile Leu Pro Ile Ser Gln Ser Phe 
            580                 585                 590         


Asp Asn Ser Leu Ser Asn Lys Val Leu Cys Phe Thr Glu Glu Asn Ala 
        595                 600                 605             


Gln Lys Ser Asn Arg Thr Pro Phe Glu Tyr Leu Asp Ala Ala Asp Phe 
    610                 615                 620                 


Gln Arg Leu Glu Ala Ile Ser Gly Asn Trp Pro Glu Ala Lys Arg Asn 
625                 630                 635                 640 


Lys Leu Leu His Lys Ser Phe Gly Lys Val Ala Glu Glu Trp Lys Ser 
                645                 650                 655     


Arg Ala Leu Asn Asp Thr Arg Tyr Leu Thr Ser Ala Leu Ala Asp His 
            660                 665                 670         


Leu Arg His His Leu Pro Asp Ser Lys Ile Gln Thr Val Asn Gly Arg 
        675                 680                 685             


Ile Thr Gly Tyr Leu Arg Lys Gln Trp Gly Leu Glu Lys Asp Arg Asp 
    690                 695                 700                 


Lys His Thr His His Ala Val Asp Ala Ile Val Val Ala Cys Thr Thr 
705                 710                 715                 720 


Pro Ala Ile Val Gln Gln Val Thr Leu Tyr His Gln Asp Ile Arg Arg 
                725                 730                 735     


Tyr Lys Lys Leu Gly Glu Lys Arg Pro Thr Pro Trp Pro Glu Thr Phe 
            740                 745                 750         


Arg Gln Asp Val Leu Asp Val Glu Glu Glu Ile Phe Ile Thr Arg Gln 
        755                 760                 765             


Pro Lys Lys Val Ser Gly Gly Ile Gln Thr Lys Asp Thr Leu Arg Lys 
    770                 775                 780                 


His Arg Ser Lys Pro Asp Arg Gln Arg Val Ala Leu Thr Lys Val Lys 
785                 790                 795                 800 


Leu Ala Asp Leu Glu Arg Leu Val Glu Lys Asp Ala Ser Asn Arg Asn 
                805                 810                 815     


Leu Tyr Glu His Leu Lys Gln Cys Leu Glu Glu Ser Gly Asp Gln Pro 
            820                 825                 830         


Thr Lys Ala Phe Lys Ala Pro Phe Tyr Met Pro Ser Gly Pro Glu Ala 
        835                 840                 845             


Lys Gln Arg Pro Ile Leu Ser Lys Val Thr Leu Leu Arg Glu Lys Pro 
    850                 855                 860                 


Glu Pro Pro Lys Gln Leu Thr Glu Leu Ser Gly Gly Arg Arg Tyr Asp 
865                 870                 875                 880 


Ser Met Ala Gln Gly Arg Leu Asp Ile Tyr Arg Tyr Lys Pro Gly Gly 
                885                 890                 895     


Lys Arg Lys Asp Glu Tyr Arg Val Val Leu Gln Arg Met Ile Asp Leu 
            900                 905                 910         


Met Arg Gly Glu Glu Asn Val His Val Phe Gln Lys Gly Val Pro Tyr 
        915                 920                 925             


Asp Gln Gly Pro Glu Ile Glu Gln Asn Tyr Thr Phe Leu Phe Ser Leu 
    930                 935                 940                 


Tyr Phe Asp Asp Leu Val Glu Phe Gln Arg Ser Ala Asp Ser Glu Val 
945                 950                 955                 960 


Ile Arg Gly Tyr Tyr Arg Thr Phe Asn Ile Ala Asn Gly Gln Leu Lys 
                965                 970                 975     


Ile Ser Thr Tyr Leu Glu Gly Arg Gln Asp Phe Asp Phe Phe Gly Ala 
            980                 985                 990         


Asn Arg Leu Ala His Phe Ala Lys  Val Gln Val Asn Leu  Leu Gly Lys 
        995                 1000                 1005             


Val Ile  Lys 
    1010     


<210> 611
<211> 1032
<212> PRT
<213> Unknown


<220>
<223> Description of Unknown:
      uncultured Termite group 1 bacterium phylotype Rs-D17
      polypeptide

<400> 611
Met Leu Tyr His Ile Ala Asn His Arg Gly Thr Asp Ser Val Arg Ser 
1               5                   10                  15      


Phe Leu Glu Tyr Asp Asp Asp Lys Ile Lys Glu Asn Thr Leu Thr Ala 
            20                  25                  30          


Lys Ile Ala Lys Glu Thr Lys Lys Val Ile Asp Ala Lys Lys Tyr Arg 
        35                  40                  45              


Thr Phe Gly Glu Tyr Leu Tyr Lys Gly Lys Ile Glu Lys Phe Gln Gln 
    50                  55                  60                  


Asn Ile Arg Lys Lys Val Ser Asn Arg Lys Thr Pro Ala Asn Lys Asn 
65                  70                  75                  80  


Lys Glu Phe Ala Val Thr Arg Asp Val Ile Ile Lys Glu Thr Glu Lys 
                85                  90                  95      


Ile Leu Ala Ser Gln Lys Gln Tyr Tyr Thr Tyr Ile Leu Thr Asp Glu 
            100                 105                 110         


Tyr Ile Lys Lys Ile Lys Asp Ala Ile Ser Tyr Gln Thr Glu Lys Leu 
        115                 120                 125             


Ile Pro Glu Ser Gly Tyr Cys Pro Tyr Phe Lys Asp Glu Lys Arg Leu 
    130                 135                 140                 


Pro Arg Ser His Lys Leu Asn Glu Tyr Arg Arg Met Tyr Glu Ala Leu 
145                 150                 155                 160 


Asn Asn Ala Lys Tyr Phe Asp Pro Val Leu Asp Glu Asn Thr Gly Glu 
                165                 170                 175     


Ile Leu Ser Tyr Gln Glu Lys Glu Phe Ser Arg Glu Glu Lys Lys Ile 
            180                 185                 190         


Leu Phe Asp Glu Val Leu Leu Lys Gly Met Glu Leu Thr Glu Ser Gly 
        195                 200                 205             


Ala Lys Lys Leu Leu Tyr His Leu Pro Asp Gly Cys Glu Val Gln Leu 
    210                 215                 220                 


Gln Gly Arg Asp Lys Thr Thr Gln Lys Ile Lys Gly Tyr Ala Leu Val 
225                 230                 235                 240 


Asp Leu Glu Ala Ser Pro Phe Trp Leu Arg Leu Ser Gln Gln Gln Gln 
                245                 250                 255     


Asp Glu Phe Leu Tyr Asp Trp Asn Ser Leu Pro Leu Glu Lys Leu Lys 
            260                 265                 270         


Pro Lys Leu Thr Asn Tyr Tyr Ser Leu Thr Glu Ser Glu Val Asp Glu 
        275                 280                 285             


Thr Phe Gln Glu Ile Lys Leu Pro Ser Asn Tyr Ala Ser Val Gly Lys 
    290                 295                 300                 


Lys Ala Met Glu Ile Leu Leu Thr Tyr Ile Lys Asp Gly Cys Ser Tyr 
305                 310                 315                 320 


Thr Glu Ala Leu Glu Lys Ala Val Ser Glu Gly Lys Leu Lys Val Asp 
                325                 330                 335     


Lys Gln Thr Met Ile Tyr Asp Ser Leu Pro Tyr Tyr Gly Lys Ile Leu 
            340                 345                 350         


Lys Glu Ser Thr Gln Lys Leu Ile Gly Lys Ala Phe Ser Lys Gln Phe 
        355                 360                 365             


Ala Asp Arg Asn Tyr Lys Glu Pro Asp Thr Asn Lys Asn Glu Arg Glu 
    370                 375                 380                 


Phe Gly Lys Ile Ala Asn Pro Val Val His Gln Thr Leu Asn Glu Leu 
385                 390                 395                 400 


Arg Lys Leu Ile Asn Glu Ile Ile Thr Val Phe Gly Lys Lys Pro Leu 
                405                 410                 415     


Glu Ile Gly Leu Glu Thr Thr Arg Glu Leu Lys Lys Ser Lys Lys Asn 
            420                 425                 430         


Arg Glu Tyr Leu Ser Lys Gln Gln Asn Lys Asn Glu Tyr Ala Arg Asn 
        435                 440                 445             


Arg Ile Tyr Lys Glu Tyr Ile Glu Pro His Leu Ser Gln Ile Lys Ser 
    450                 455                 460                 


Arg Gln Glu Asn Pro Ser Lys Tyr Ile Ser Lys Phe Glu Leu Leu Glu 
465                 470                 475                 480 


Glu Gln Asn Phe Ile Cys Pro Phe Cys Ser Glu Lys Ile Thr Pro Asp 
                485                 490                 495     


Asp Ile Ile Asn Ser Lys Val Asp Val Glu His Ile Phe Pro Ile Glu 
            500                 505                 510         


Glu Ser Glu Asp Ile Thr Lys Asn Asn Leu Val Ile Ala His Asn Glu 
        515                 520                 525             


Cys Asn Ala Asp Lys Gly Lys Lys Ser Pro Phe Asp Ala Phe Gly Asp 
    530                 535                 540                 


Lys Thr Ser Gly Lys Tyr Arg Trp Asn Cys Ile Leu His Asn Ala Gln 
545                 550                 555                 560 


Lys Asn Leu Pro His Lys Val Trp Arg Phe Tyr Gln Gly Ser Leu Glu 
                565                 570                 575     


Lys Phe Leu Glu Asn Lys Pro Met Ser Arg Arg Phe Gly Thr Asp Asn 
            580                 585                 590         


Ser Tyr Ile Ser Lys Ile Ala Ala Arg Tyr Leu Ala Cys Leu Phe Asn 
        595                 600                 605             


Asp Pro Tyr His Ser Glu Ile Phe Cys Ile Lys Ser Ser Leu Ile Ala 
    610                 615                 620                 


Gln Leu Arg Ile Ala Trp Asp Leu Asn Ser Ile Met Val Pro Leu Val 
625                 630                 635                 640 


Lys Asn Ile Leu Ser Glu Lys Glu Leu Glu Glu Phe Lys Ile Ser Lys 
                645                 650                 655     


Asn Lys Lys Ile Arg Ile Asp Asn Arg His His Ala Leu Asp Ala Ile 
            660                 665                 670         


Val Ile Ala Tyr Ala Asn Arg Gly Tyr His Asn Phe Leu Asn Arg Ile 
        675                 680                 685             


His Ala Lys Glu Tyr Lys Ile Asn Tyr Arg Glu Lys Ser Trp Leu Ser 
    690                 695                 700                 


Lys Ile Leu Leu Pro Pro Leu Asn Arg Asp Leu Glu Asp Phe Lys Ile 
705                 710                 715                 720 


Ser Val Lys Asp Ser Ile Glu Lys Ala Asn Val Ser Ile Lys His Asp 
                725                 730                 735     


His Asn Thr Asn Gly Ser Leu Val Lys Ala Thr Ala Tyr Lys Val Tyr 
            740                 745                 750         


Tyr Ser Gly Ala Gly Glu Tyr Ile Ile Thr Thr Ser Lys Asn Val Glu 
        755                 760                 765             


Glu Ile Ser Phe Lys Glu Lys Glu Asp Pro Lys Asp Thr Leu Tyr Arg 
    770                 775                 780                 


Ala Leu Cys Lys Phe Glu Cys Arg Asp Ile Asp Ile Lys Asp Glu Lys 
785                 790                 795                 800 


Leu Ile Lys Lys Leu Lys Tyr Asn Ser Thr Leu Tyr Lys Lys Val Gln 
                805                 810                 815     


Asn Asn Leu Ser Lys Ala Lys Gln Glu Leu Glu Gln Asp Asn Lys Lys 
            820                 825                 830         


Thr Glu Glu Glu Gly Lys Lys Ser Gln Lys Ile Thr Glu Val Arg Ile 
        835                 840                 845             


Tyr Lys Lys Ala Cys Ser Leu Val Lys Gly Gln Tyr Ile Gln Cys Gly 
    850                 855                 860                 


Ser Arg Leu Lys Asp Lys Phe Phe Ala Val Lys Glu Pro Thr Glu Ile 
865                 870                 875                 880 


Lys Thr Gly Leu Gly Tyr Asp Thr Gly Asp Asn Leu Phe Leu Asp Leu 
                885                 890                 895     


Tyr Tyr Asp Lys Thr Gly Lys Leu Cys Gly Glu Ile Ile Arg Lys Val 
            900                 905                 910         


Asn Phe Asn Arg Asn Lys Pro Asn Tyr Gln Lys Glu Gly Tyr Thr Leu 
        915                 920                 925             


Phe Glu Arg Ile Tyr Gln Ser Asp Ile Leu Glu Val Asp Thr Ser Glu 
    930                 935                 940                 


Asp Arg Ile Ser Leu Lys Asn Lys Thr Gly Ser Ala Pro Ser Asp Arg 
945                 950                 955                 960 


Thr Phe Ile Lys Val Asn Thr Phe Thr Glu Val Asn Ala Tyr Phe Asp 
                965                 970                 975     


Gly Lys Arg Asp Lys Ile Gln Ile Phe Phe Gly Asn Leu Leu Lys Ser 
            980                 985                 990         


Ser Phe Lys Asn Asp Ser Phe Phe  Ile Ser Ser Met Gln  Lys Tyr Asn 
        995                 1000                 1005             


Val Arg  Lys Val Ile Leu Thr  Ser Leu Gly Ile Ile  Lys Tyr Arg 
    1010                 1015                 1020             


Ser Gln  Ile Leu Lys Asn Lys  Glu Val 
    1025                 1030         


<210> 612
<211> 1398
<212> PRT
<213> Veillonella atypica


<220>
<223> Veillonella atypica ACS-134-V-Col7a

<400> 612
Met Glu Thr Gln Thr Ser Asn Gln Leu Ile Thr Ser His Leu Lys Asp 
1               5                   10                  15      


Tyr Pro Lys Gln Asp Tyr Phe Val Gly Leu Asp Ile Gly Thr Asn Ser 
            20                  25                  30          


Val Gly Trp Ala Val Thr Asn Thr Ser Tyr Glu Leu Leu Lys Phe His 
        35                  40                  45              


Ser His Lys Met Trp Gly Ser Arg Leu Phe Glu Glu Gly Glu Ser Ala 
    50                  55                  60                  


Val Thr Arg Arg Gly Phe Arg Ser Met Arg Arg Arg Leu Glu Arg Arg 
65                  70                  75                  80  


Lys Leu Arg Leu Lys Leu Leu Glu Glu Leu Phe Ala Asp Ala Met Ala 
                85                  90                  95      


Gln Val Asp Ser Thr Phe Phe Ile Arg Leu His Glu Ser Lys Tyr His 
            100                 105                 110         


Tyr Glu Asp Lys Thr Thr Gly His Ser Ser Lys His Ile Leu Phe Ile 
        115                 120                 125             


Asp Glu Asp Tyr Thr Asp Gln Asp Tyr Phe Thr Glu Tyr Pro Thr Ile 
    130                 135                 140                 


Tyr His Leu Arg Lys Asp Leu Met Glu Asn Gly Thr Asp Asp Ile Arg 
145                 150                 155                 160 


Lys Leu Phe Leu Ala Val His His Ile Leu Lys Tyr Arg Gly Asn Phe 
                165                 170                 175     


Leu Tyr Glu Gly Ala Thr Phe Asn Ser Asn Ala Phe Thr Phe Glu Asp 
            180                 185                 190         


Val Leu Lys Gln Ala Leu Val Asn Ile Thr Phe Asn Cys Phe Asp Thr 
        195                 200                 205             


Asn Ser Ala Ile Ser Ser Ile Ser Asn Ile Leu Met Glu Ser Gly Lys 
    210                 215                 220                 


Thr Lys Ser Asp Lys Ala Lys Ala Ile Glu Arg Leu Val Asp Thr Tyr 
225                 230                 235                 240 


Thr Val Phe Asp Glu Val Asn Thr Pro Asp Lys Pro Gln Lys Glu Gln 
                245                 250                 255     


Val Lys Glu Asp Lys Lys Thr Leu Lys Ala Phe Ala Asn Leu Val Leu 
            260                 265                 270         


Gly Leu Ser Ala Asn Leu Ile Asp Leu Phe Gly Ser Val Glu Asp Ile 
        275                 280                 285             


Asp Asp Asp Leu Lys Lys Leu Gln Ile Val Gly Asp Thr Tyr Asp Glu 
    290                 295                 300                 


Lys Arg Asp Glu Leu Ala Lys Val Trp Gly Asp Glu Ile His Ile Ile 
305                 310                 315                 320 


Asp Asp Cys Lys Ser Val Tyr Asp Ala Ile Ile Leu Met Ser Ile Lys 
                325                 330                 335     


Glu Pro Gly Leu Thr Ile Ser Gln Ser Lys Val Lys Ala Phe Asp Lys 
            340                 345                 350         


His Lys Glu Asp Leu Val Ile Leu Lys Ser Leu Leu Lys Leu Asp Arg 
        355                 360                 365             


Asn Val Tyr Asn Glu Met Phe Lys Ser Asp Lys Lys Gly Leu His Asn 
    370                 375                 380                 


Tyr Val His Tyr Ile Lys Gln Gly Arg Thr Glu Glu Thr Ser Cys Ser 
385                 390                 395                 400 


Arg Glu Asp Phe Tyr Lys Tyr Thr Lys Lys Ile Val Glu Gly Leu Ala 
                405                 410                 415     


Asp Ser Lys Asp Lys Glu Tyr Ile Leu Asn Glu Ile Glu Leu Gln Thr 
            420                 425                 430         


Leu Leu Pro Leu Gln Arg Ile Lys Asp Asn Gly Val Ile Pro Tyr Gln 
        435                 440                 445             


Leu His Leu Glu Glu Leu Lys Val Ile Leu Asp Lys Cys Gly Pro Lys 
    450                 455                 460                 


Phe Pro Phe Leu His Thr Val Ser Asp Gly Phe Ser Val Thr Glu Lys 
465                 470                 475                 480 


Leu Ile Lys Met Leu Glu Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu 
                485                 490                 495     


Asn Thr His His Asn Ile Asp Asn Gly Gly Phe Ser Trp Ala Val Arg 
            500                 505                 510         


Lys Gln Ala Gly Arg Val Thr Pro Trp Asn Phe Glu Glu Lys Ile Asp 
        515                 520                 525             


Arg Glu Lys Ser Ala Ala Ala Phe Ile Lys Asn Leu Thr Asn Lys Cys 
    530                 535                 540                 


Thr Tyr Leu Phe Gly Glu Asp Val Leu Pro Lys Ser Ser Leu Leu Tyr 
545                 550                 555                 560 


Ser Glu Phe Met Leu Leu Asn Glu Leu Asn Asn Val Arg Ile Asp Gly 
                565                 570                 575     


Lys Ala Leu Ala Gln Gly Val Lys Gln His Leu Ile Asp Ser Ile Phe 
            580                 585                 590         


Lys Gln Asp His Lys Lys Met Thr Lys Asn Arg Ile Glu Leu Phe Leu 
        595                 600                 605             


Lys Asp Asn Asn Tyr Ile Thr Lys Lys His Lys Pro Glu Ile Thr Gly 
    610                 615                 620                 


Leu Asp Gly Glu Ile Lys Asn Asp Leu Thr Ser Tyr Arg Asp Met Val 
625                 630                 635                 640 


Arg Ile Leu Gly Asn Asn Phe Asp Val Ser Met Ala Glu Asp Ile Ile 
                645                 650                 655     


Thr Asp Ile Thr Ile Phe Gly Glu Ser Lys Lys Met Leu Arg Gln Thr 
            660                 665                 670         


Leu Arg Asn Lys Phe Gly Ser Gln Leu Asn Asp Glu Thr Ile Lys Lys 
        675                 680                 685             


Leu Ser Lys Leu Arg Tyr Arg Asp Trp Gly Arg Leu Ser Lys Lys Leu 
    690                 695                 700                 


Leu Lys Gly Ile Asp Gly Cys Asp Lys Ala Gly Asn Gly Ala Pro Lys 
705                 710                 715                 720 


Thr Ile Ile Glu Leu Met Arg Asn Asp Ser Tyr Asn Leu Met Glu Ile 
                725                 730                 735     


Leu Gly Asp Lys Phe Ser Phe Met Glu Cys Ile Glu Glu Glu Asn Ala 
            740                 745                 750         


Lys Leu Ala Gln Gly Gln Val Val Asn Pro His Asp Ile Ile Asp Glu 
        755                 760                 765             


Leu Ala Leu Ser Pro Ala Val Lys Arg Ala Val Trp Gln Ala Leu Arg 
    770                 775                 780                 


Ile Val Asp Glu Val Ala His Ile Lys Lys Ala Leu Pro Ser Arg Ile 
785                 790                 795                 800 


Phe Val Glu Val Ala Arg Thr Asn Lys Ser Glu Lys Lys Lys Lys Asp 
                805                 810                 815     


Ser Arg Gln Lys Arg Leu Ser Asp Leu Tyr Ser Ala Ile Lys Lys Asp 
            820                 825                 830         


Asp Val Leu Gln Ser Gly Leu Gln Asp Lys Glu Phe Gly Ala Leu Lys 
        835                 840                 845             


Ser Gly Leu Ala Asn Tyr Asp Asp Ala Ala Leu Arg Ser Lys Lys Leu 
    850                 855                 860                 


Tyr Leu Tyr Tyr Thr Gln Met Gly Arg Cys Ala Tyr Thr Gly Asn Ile 
865                 870                 875                 880 


Ile Asp Leu Asn Gln Leu Asn Thr Asp Asn Tyr Asp Ile Asp His Ile 
                885                 890                 895     


Tyr Pro Arg Ser Leu Thr Lys Asp Asp Ser Phe Asp Asn Leu Val Leu 
            900                 905                 910         


Cys Glu Arg Thr Ala Asn Ala Lys Lys Ser Asp Ile Tyr Pro Ile Asp 
        915                 920                 925             


Asn Arg Ile Gln Thr Lys Gln Lys Pro Phe Trp Ala Phe Leu Lys His 
    930                 935                 940                 


Gln Gly Leu Ile Ser Glu Arg Lys Tyr Glu Arg Leu Thr Arg Ile Ala 
945                 950                 955                 960 


Pro Leu Thr Ala Asp Asp Leu Ser Gly Phe Ile Ala Arg Gln Leu Val 
                965                 970                 975     


Glu Thr Asn Gln Ser Val Lys Ala Thr Thr Thr Leu Leu Arg Arg Leu 
            980                 985                 990         


Tyr Pro Asp Ile Asp Val Val Phe  Val Lys Ala Glu Asn  Val Ser Asp 
        995                 1000                 1005             


Phe Arg  His Asn Asn Asn Phe  Ile Lys Val Arg Ser  Leu Asn His 
    1010                 1015                 1020             


His His  His Ala Lys Asp Ala  Tyr Leu Asn Ile Val  Val Gly Asn 
    1025                 1030                 1035             


Val Tyr  His Glu Lys Phe Thr  Arg Asn Phe Arg Leu  Phe Phe Lys 
    1040                 1045                 1050             


Lys Asn  Gly Ala Asn Arg Thr  Tyr Asn Leu Ala Lys  Met Phe Asn 
    1055                 1060                 1065             


Tyr Asp  Val Ile Cys Thr Asn  Ala Gln Asp Gly Lys  Ala Trp Asp 
    1070                 1075                 1080             


Val Lys  Thr Ser Met Asn Thr  Val Lys Lys Met Met  Ala Ser Asn 
    1085                 1090                 1095             


Asp Val  Arg Val Thr Arg Arg  Leu Leu Glu Gln Ser  Gly Ala Leu 
    1100                 1105                 1110             


Ala Asp  Ala Thr Ile Tyr Lys  Ala Ser Val Ala Ala  Lys Ala Lys 
    1115                 1120                 1125             


Asp Gly  Ala Tyr Ile Gly Met  Lys Thr Lys Tyr Ser  Val Phe Ala 
    1130                 1135                 1140             


Asp Val  Thr Lys Tyr Gly Gly  Met Thr Lys Ile Lys  Asn Ala Tyr 
    1145                 1150                 1155             


Ser Ile  Ile Val Gln Tyr Thr  Gly Lys Lys Gly Glu  Glu Ile Lys 
    1160                 1165                 1170             


Glu Ile  Val Pro Leu Pro Ile  Tyr Leu Ile Asn Arg  Asn Ala Thr 
    1175                 1180                 1185             


Asp Ile  Glu Leu Ile Asp Tyr  Val Lys Ser Val Ile  Pro Lys Ala 
    1190                 1195                 1200             


Lys Asp  Ile Ser Ile Lys Tyr  Arg Lys Leu Cys Ile  Asn Gln Leu 
    1205                 1210                 1215             


Val Lys  Val Asn Gly Phe Tyr  Tyr Tyr Leu Gly Gly  Lys Thr Asn 
    1220                 1225                 1230             


Asp Lys  Ile Tyr Ile Asp Asn  Ala Ile Glu Leu Val  Val Pro His 
    1235                 1240                 1245             


Asp Ile  Ala Thr Tyr Ile Lys  Leu Leu Asp Lys Tyr  Asp Leu Leu 
    1250                 1255                 1260             


Arg Lys  Glu Asn Lys Thr Leu  Lys Ala Ser Ser Ile  Thr Thr Ser 
    1265                 1270                 1275             


Ile Tyr  Asn Ile Asn Thr Ser  Thr Val Val Ser Leu  Ser Asn Lys 
    1280                 1285                 1290             


Val Gly  Ile Asp Val Phe Asp  Tyr Phe Met Ser Lys  Leu Arg Thr 
    1295                 1300                 1305             


Pro Leu  Tyr Met Lys Met Lys  Gly Asn Lys Val Asp  Glu Leu Ser 
    1310                 1315                 1320             


Ser Thr  Gly Arg Ser Lys Phe  Ile Lys Met Thr Leu  Glu Glu Gln 
    1325                 1330                 1335             


Ser Ile  Tyr Leu Leu Glu Val  Leu Asn Leu Leu Thr  Asn Ser Lys 
    1340                 1345                 1350             


Thr Thr  Phe Asp Val Lys Pro  Leu Gly Ile Thr Gly  Ser Arg Ser 
    1355                 1360                 1365             


Thr Ile  Gly Val Lys Ile His  Asn Leu Asp Glu Phe  Lys Ile Ile 
    1370                 1375                 1380             


Asn Glu  Ser Ile Thr Gly Leu  Tyr Ser Asn Glu Val  Thr Ile Val 
    1385                 1390                 1395             


<210> 613
<211> 1398
<212> PRT
<213> Veillonella parvula


<220>
<223> Veillonella parvula ATCC 17745

<400> 613
Met Glu Thr Gln Ala Ser Asn Gln Leu Ile Ser Ser His Leu Lys Gly 
1               5                   10                  15      


Tyr Pro Ile Lys Asp Tyr Phe Val Gly Leu Asp Ile Gly Thr Ser Ser 
            20                  25                  30          


Val Gly Trp Ala Val Thr Asn Lys Ala Tyr Glu Leu Leu Lys Phe Arg 
        35                  40                  45              


Ser His Lys Met Trp Gly Ser Arg Leu Phe Asp Glu Gly Glu Ser Ala 
    50                  55                  60                  


Val Ala Arg Arg Gly Phe Arg Ser Met Arg Arg Arg Leu Glu Arg Arg 
65                  70                  75                  80  


Lys Leu Arg Leu Lys Leu Leu Glu Glu Leu Phe Ala Asp Ala Met Ala 
                85                  90                  95      


Gln Val Asp Pro Thr Phe Phe Met Arg Leu Arg Glu Ser Lys Tyr His 
            100                 105                 110         


Tyr Glu Asp Lys Thr Thr Gly His Ser Ser Lys His Ile Leu Phe Ile 
        115                 120                 125             


Asp Lys Asn Tyr Asn Asp Gln Asp Tyr Phe Lys Glu Tyr Pro Thr Val 
    130                 135                 140                 


Tyr His Leu Arg Ser Glu Leu Met Lys Ser Gly Thr Asp Asp Ile Arg 
145                 150                 155                 160 


Lys Leu Phe Leu Ala Val His His Ile Leu Lys Tyr Arg Gly Asn Phe 
                165                 170                 175     


Leu Tyr Glu Gly Ala Thr Phe Asp Ser Asn Ala Ser Thr Leu Asp Asp 
            180                 185                 190         


Val Ile Lys Gln Ala Leu Glu Asn Ile Thr Phe Asn Cys Phe Asp Cys 
        195                 200                 205             


Asn Ser Ala Ile Ser Ser Ile Gly Gln Ile Leu Met Glu Ala Gly Lys 
    210                 215                 220                 


Thr Lys Ser Asp Lys Ala Lys Ala Ile Glu His Leu Val Asp Thr Tyr 
225                 230                 235                 240 


Ile Ala Thr Asp Thr Val Asp Thr Ser Ser Lys Thr Gln Lys Asp Gln 
                245                 250                 255     


Val Lys Glu Asp Lys Lys Arg Leu Lys Ala Phe Ala Asn Leu Val Leu 
            260                 265                 270         


Gly Leu Asn Ala Ser Leu Ile Asp Leu Phe Gly Ser Val Glu Glu Leu 
        275                 280                 285             


Glu Glu Asp Leu Lys Lys Leu Gln Ile Thr Gly Asp Thr Tyr Asp Asp 
    290                 295                 300                 


Lys Arg Asp Glu Leu Ala Lys Ala Trp Ser Asp Glu Ile Tyr Ile Ile 
305                 310                 315                 320 


Asp Asp Cys Lys Ser Val Tyr Asp Ala Ile Ile Leu Leu Ser Ile Lys 
                325                 330                 335     


Glu Pro Gly Leu Thr Ile Ser Glu Ser Lys Val Lys Ala Phe Asn Lys 
            340                 345                 350         


His Lys Asp Asp Leu Ala Ile Leu Lys Ser Leu Leu Lys Ser Asp Arg 
        355                 360                 365             


Ser Ile Tyr Asn Thr Met Phe Lys Val Asp Glu Lys Gly Leu His Asn 
    370                 375                 380                 


Tyr Val His Tyr Ile Lys Gln Gly Arg Thr Glu Glu Thr Ser Cys Asn 
385                 390                 395                 400 


Arg Glu Asp Phe Tyr Lys Tyr Thr Lys Lys Ile Val Glu Gly Leu Ser 
                405                 410                 415     


Asp Ser Lys Asp Lys Glu Tyr Ile Leu Ser Gln Ile Glu Leu Gln Ile 
            420                 425                 430         


Leu Leu Pro Leu Gln Arg Ile Lys Asp Asn Gly Val Ile Pro Tyr Gln 
        435                 440                 445             


Leu His Leu Glu Glu Leu Lys Ala Ile Leu Ala Lys Cys Gly Pro Lys 
    450                 455                 460                 


Phe Pro Phe Leu Asn Glu Val Ala Asp Gly Phe Ser Val Ala Glu Lys 
465                 470                 475                 480 


Leu Ile Lys Met Leu Glu Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu 
                485                 490                 495     


Asn Thr His His Asn Val Asp Asn Gly Gly Phe Ala Trp Ala Val Arg 
            500                 505                 510         


Lys Ala Ser Gly Arg Val Thr Pro Trp Asn Phe Asp Asp Lys Ile Asp 
        515                 520                 525             


Arg Glu Lys Ser Ala Ala Ala Phe Ile Lys Asn Leu Thr Asn Lys Cys 
    530                 535                 540                 


Thr Tyr Leu Leu Gly Glu Asp Val Leu Pro Lys Ser Ser Leu Leu Tyr 
545                 550                 555                 560 


Ser Glu Phe Met Leu Leu Asn Glu Leu Asn Asn Val Arg Ile Asp Gly 
                565                 570                 575     


Lys Pro Leu Glu Lys Val Val Lys Glu His Leu Ile Glu Ala Val Phe 
            580                 585                 590         


Lys Gln Asp His Lys Lys Met Thr Lys Asn Arg Ile Glu Gln Phe Leu 
        595                 600                 605             


Lys Asp Asn Gly Tyr Ile Ser Glu Thr His Lys His Glu Ile Thr Gly 
    610                 615                 620                 


Leu Asp Gly Glu Ile Lys Asn Asp Leu Ala Ser Tyr Arg Asp Met Val 
625                 630                 635                 640 


Arg Ile Leu Gly Asp Gly Phe Asp Arg Ser Met Ala Glu Glu Ile Ile 
                645                 650                 655     


Thr Asp Ile Thr Ile Phe Gly Glu Ser Lys Lys Met Leu Arg Glu Thr 
            660                 665                 670         


Leu Arg Lys Lys Phe Ala Ser Cys Leu Asp Asp Glu Ala Ile Lys Lys 
        675                 680                 685             


Leu Thr Lys Leu Arg Tyr Arg Asp Trp Gly Arg Leu Ser Gln Lys Leu 
    690                 695                 700                 


Leu Asn Gly Ile Glu Gly Cys Asp Lys Ala Gly Asp Gly Thr Pro Glu 
705                 710                 715                 720 


Thr Ile Ile Ile Leu Met Arg Asn Phe Ser Tyr Asn Leu Met Glu Leu 
                725                 730                 735     


Leu Gly Asp Lys Phe Ser Phe Met Glu Arg Ile Gln Glu Ile Asn Ala 
            740                 745                 750         


Lys Leu Thr Glu Gly Gln Ile Val Asn Pro His Asp Ile Ile Asp Asp 
        755                 760                 765             


Leu Ala Leu Ser Pro Ala Val Lys Arg Ala Val Trp Gln Ala Leu Arg 
    770                 775                 780                 


Ile Val Asp Glu Val Ala His Ile Lys Lys Ala Leu Pro Ala Arg Ile 
785                 790                 795                 800 


Phe Val Glu Val Thr Arg Ser Asn Lys Asn Glu Lys Lys Lys Lys Asp 
                805                 810                 815     


Ser Arg Gln Lys Arg Leu Ser Asp Leu Tyr Ala Ala Ile Lys Lys Asp 
            820                 825                 830         


Asp Val Leu Leu Asn Gly Leu Asn Asn Glu Ile Phe Gly Glu Leu Lys 
        835                 840                 845             


Ser Ser Leu Ala Lys Tyr Asp Asp Ala Ala Leu Arg Ser Lys Lys Leu 
    850                 855                 860                 


Tyr Leu Tyr Tyr Thr Gln Met Gly Arg Cys Ala Tyr Thr Gly Glu Ile 
865                 870                 875                 880 


Ile Glu Leu Ser Leu Leu Asn Thr Asp Asn Tyr Asp Ile Asp His Ile 
                885                 890                 895     


Tyr Pro Arg Ser Leu Thr Lys Asp Asp Ser Phe Asp Asn Leu Val Leu 
            900                 905                 910         


Cys Lys Arg Thr Ala Asn Ala Gln Lys Ser Asp Ala Tyr Pro Ile Ser 
        915                 920                 925             


Glu Glu Ile Gln Lys Thr Gln Lys Pro Phe Trp Thr Phe Leu Lys Gln 
    930                 935                 940                 


Gln Gly Leu Ile Ser Glu Arg Lys Tyr Glu Arg Leu Thr Arg Ile Thr 
945                 950                 955                 960 


Pro Leu Thr Ala Asp Asp Leu Ser Gly Phe Ile Ala Arg Gln Leu Val 
                965                 970                 975     


Glu Thr Asn Gln Ser Val Lys Ala Ala Thr Thr Leu Leu Arg Arg Leu 
            980                 985                 990         


Tyr Pro Gly Val Asp Val Val Phe  Val Lys Ala Glu Asn  Val Thr Asp 
        995                 1000                 1005             


Phe Arg  His Asp Asn Asn Phe  Ile Lys Val Arg Ser  Leu Asn His 
    1010                 1015                 1020             


His His  His Ala Lys Asp Ala  Tyr Leu Asn Ile Val  Val Gly Asn 
    1025                 1030                 1035             


Val Tyr  His Glu Arg Phe Thr  Arg Asn Phe Arg Ala  Phe Phe Lys 
    1040                 1045                 1050             


Lys Asn  Gly Ala Asn Arg Thr  Tyr Asn Leu Ala Lys  Met Phe Asn 
    1055                 1060                 1065             


Tyr Asp  Val Asn Cys Thr Asn  Ala Lys Asp Gly Lys  Ala Trp Asp 
    1070                 1075                 1080             


Val Lys  Thr Ser Met Asp Thr  Val Lys Lys Met Met  Asp Ser Asn 
    1085                 1090                 1095             


Asp Val  Arg Val Thr Lys Arg  Leu Leu Glu Gln Thr  Gly Ala Leu 
    1100                 1105                 1110             


Ala Asp  Ala Thr Ile Tyr Lys  Ala Thr Val Ala Gly  Lys Ala Lys 
    1115                 1120                 1125             


Asp Gly  Ala Tyr Ile Gly Met  Lys Thr Lys Ser Ser  Val Phe Ala 
    1130                 1135                 1140             


Asp Val  Ser Lys Tyr Gly Gly  Met Thr Lys Ile Lys  Asn Ala Tyr 
    1145                 1150                 1155             


Ser Ile  Ile Val Gln Tyr Thr  Gly Lys Lys Gly Glu  Val Ile Lys 
    1160                 1165                 1170             


Glu Ile  Val Pro Leu Pro Ile  Tyr Leu Thr Asn Arg  Asn Thr Thr 
    1175                 1180                 1185             


Asp Gln  Asp Leu Ile Asn Tyr  Val Ala Ser Ile Ile  Pro Gln Ala 
    1190                 1195                 1200             


Lys Asp  Ile Ser Ile Ile Tyr  Gly Lys Leu Cys Ile  Asn Gln Leu 
    1205                 1210                 1215             


Val Lys  Val Asn Gly Phe Tyr  Tyr Tyr Leu Gly Gly  Lys Thr Asn 
    1220                 1225                 1230             


Ser Lys  Phe Cys Ile Asp Asn  Ala Ile Gln Val Ile  Val Ser Asn 
    1235                 1240                 1245             


Glu Trp  Ile Pro Tyr Leu Lys  Val Leu Glu Lys Phe  Asn Asn Met 
    1250                 1255                 1260             


Arg Lys  Asp Asn Lys Asp Leu  Lys Ala Asn Val Val  Ser Thr Arg 
    1265                 1270                 1275             


Ala Leu  Asp Asn Lys His Thr  Ile Glu Val Arg Ile  Val Glu Glu 
    1280                 1285                 1290             


Lys Asn  Ile Glu Phe Phe Asp  Tyr Leu Val Ser Lys  Leu Lys Met 
    1295                 1300                 1305             


Pro Ile  Tyr Gln Lys Met Lys  Gly Asn Lys Ala Ala  Glu Leu Ser 
    1310                 1315                 1320             


Glu Lys  Gly Tyr Gly Leu Phe  Lys Lys Met Ser Leu  Glu Glu Gln 
    1325                 1330                 1335             


Ser Ile  His Leu Ile Glu Leu  Leu Asn Leu Leu Thr  Asn Gln Lys 
    1340                 1345                 1350             


Thr Thr  Phe Glu Val Lys Pro  Leu Gly Ile Thr Ala  Ser Arg Ser 
    1355                 1360                 1365             


Thr Val  Gly Ser Lys Ile Ser  Asn Gln Asp Glu Phe  Lys Val Ile 
    1370                 1375                 1380             


Asn Glu  Ser Ile Thr Gly Leu  Tyr Ser Asn Glu Val  Thr Ile Val 
    1385                 1390                 1395             


<210> 614
<211> 1395
<212> PRT
<213> Veillonella sp.


<220>
<223> Veillonella sp. 6_1_27

<400> 614
Met Glu Thr Gln Ala Ser Asn Gln Leu Ile Ser Ser His Leu Lys Gly 
1               5                   10                  15      


Tyr Pro Ile Lys Asp Tyr Phe Val Gly Leu Asp Ile Gly Thr Ser Ser 
            20                  25                  30          


Val Gly Trp Ala Val Thr Asn Lys Ala Tyr Glu Leu Leu Lys Phe Arg 
        35                  40                  45              


Ser His Lys Met Trp Gly Ser Arg Leu Phe Asp Glu Gly Glu Ser Ala 
    50                  55                  60                  


Val Ala Arg Arg Gly Phe Arg Ser Met Arg Arg Arg Leu Glu Arg Arg 
65                  70                  75                  80  


Lys Leu Arg Leu Lys Leu Leu Glu Glu Leu Phe Ala Asp Ala Met Ala 
                85                  90                  95      


Gln Val Asp Pro Thr Phe Phe Met Arg Leu Arg Glu Ser Lys Tyr His 
            100                 105                 110         


Tyr Glu Asp Lys Thr Thr Gly His Ser Ser Lys His Ile Leu Phe Ile 
        115                 120                 125             


Asp Lys Asn Tyr Thr Asp Gln Asp Tyr Tyr Lys Glu Tyr Pro Thr Ile 
    130                 135                 140                 


Tyr His Leu Arg Val Ala Leu Met Lys Ser Gly Thr Asp Asp Ile Arg 
145                 150                 155                 160 


Lys Leu Phe Leu Ala Val His His Ile Leu Lys Tyr Arg Gly Asn Phe 
                165                 170                 175     


Leu Tyr Glu Gly Ala Thr Phe Asp Ser Asn Ala Ser Thr Leu Asp Asp 
            180                 185                 190         


Val Leu Lys Gln Ala Leu Glu Asn Ile Thr Phe Asn Cys Phe Asp Ser 
        195                 200                 205             


Ser Ala Ala Ile Gly Ser Ile Gly Gln Ile Leu Met Glu Leu Gly Lys 
    210                 215                 220                 


Thr Lys Ser Asp Lys Ala Lys Ala Ile Glu Arg Leu Val Asp Thr Tyr 
225                 230                 235                 240 


Ile Ile Thr Asp Glu Val Asp Thr Ser Gly Lys Thr Gln Lys Glu Gln 
                245                 250                 255     


Val Lys Glu Asp Lys Lys Arg Leu Lys Ser Phe Ala Asn Leu Val Leu 
            260                 265                 270         


Gly Leu Ser Ala Ser Leu Thr Asp Leu Phe Gly Ser Val Glu Asp Leu 
        275                 280                 285             


Asp Glu Asp Leu Lys Lys Leu Gln Ile Ile Gly Asp Thr Tyr Asp Glu 
    290                 295                 300                 


Arg Arg Asp Asp Leu Ala Lys Val Trp Gly Asp Glu Ile His Ile Ile 
305                 310                 315                 320 


Asp Asp Cys Lys Ser Val Tyr Asp Ala Ile Ile Leu Met Ser Ile Lys 
                325                 330                 335     


Glu Pro Gly Leu Thr Ile Ser Glu Ser Lys Val Lys Ala Phe Lys Lys 
            340                 345                 350         


His Lys Asp Asp Leu Ala Ile Leu Lys Ser Leu Leu Lys Ser Asp Arg 
        355                 360                 365             


Ser Ile Tyr Asn Thr Met Phe Lys Val Asp Glu Lys Gly Leu His Asn 
    370                 375                 380                 


Tyr Val His Tyr Ile Lys Gln Gly Arg Thr Glu Glu Thr Ser Cys Asn 
385                 390                 395                 400 


Arg Glu Asp Phe Tyr Lys Tyr Thr Lys Lys Val Val Glu Gly Leu Pro 
                405                 410                 415     


Asp Ser Lys Asp Lys Glu Tyr Ile Leu Ser Glu Ile Glu Leu Gln Thr 
            420                 425                 430         


Leu Leu Pro Leu Gln Arg Ile Lys Asp Asn Gly Val Ile Pro Tyr Gln 
        435                 440                 445             


Leu His Leu Glu Glu Leu Lys Val Ile Leu Ala Lys Cys Gly Pro Lys 
    450                 455                 460                 


Phe Pro Phe Leu Asn Glu Val Ala Asp Gly Phe Ser Val Ala Glu Lys 
465                 470                 475                 480 


Leu Ile Lys Met Leu Glu Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu 
                485                 490                 495     


Asn Thr His His Asn Val Asp Asn Gly Gly Phe Ala Trp Ala Val Arg 
            500                 505                 510         


Lys Ala Ser Gly Arg Val Thr Pro Trp Asn Phe Asp Asp Lys Ile Asp 
        515                 520                 525             


Arg Glu Lys Ser Ala Ala Ala Phe Ile Lys Asn Leu Thr Asn Lys Cys 
    530                 535                 540                 


Thr Tyr Leu Leu Gly Glu Asp Val Leu Pro Lys Ser Ser Leu Leu Tyr 
545                 550                 555                 560 


Ser Glu Phe Met Leu Leu Asn Glu Leu Asn Asn Val Arg Ile Asp Gly 
                565                 570                 575     


Lys Pro Leu Glu Lys Ala Val Lys Glu His Leu Ile Glu Ala Val Phe 
            580                 585                 590         


Lys Gln Asp His Lys Lys Met Thr Lys Asn Arg Ile Glu Gln Phe Leu 
        595                 600                 605             


Lys Asp Asn Asn Tyr Ile Pro Glu Lys His Lys Pro Glu Ile Thr Gly 
    610                 615                 620                 


Leu Asp Gly Glu Ile Lys Asn Asp Leu Ala Ser Tyr Arg Asp Met Val 
625                 630                 635                 640 


Arg Ile Leu Gly Asn Asn Phe Asp Leu Ser Met Ala Glu Glu Ile Ile 
                645                 650                 655     


Thr Asp Ile Thr Ile Phe Gly Glu Ser Lys Lys Met Leu Arg Glu Thr 
            660                 665                 670         


Leu Arg Asn Lys Phe Ser Ser Arg Leu Asp Asp Glu Ala Ile Lys Lys 
        675                 680                 685             


Leu Ser Lys Leu Arg Tyr Arg Asp Trp Gly Arg Leu Ser Arg Lys Leu 
    690                 695                 700                 


Leu Asn Val Ile Glu Gly Cys Asp Lys Ala Gly Asp Gly Thr Pro Glu 
705                 710                 715                 720 


Thr Ile Ile Ile Leu Met Arg Asn Phe Ser Tyr Asn Leu Met Glu Leu 
                725                 730                 735     


Leu Gly Asp Lys Phe Ser Phe Met Glu Arg Ile Gln Glu Ile Asn Ala 
            740                 745                 750         


Lys Leu Ile Glu Gly Gln Ile Val Asn Pro His Asp Ile Ile Asp Asp 
        755                 760                 765             


Leu Ala Leu Ser Pro Ala Val Lys Arg Ala Val Trp Gln Ala Leu Arg 
    770                 775                 780                 


Ile Val Asp Glu Ile Val His Ile Lys Lys Thr Leu Pro Ala Arg Ile 
785                 790                 795                 800 


Phe Val Glu Val Thr Arg Ser Asn Lys Ala Glu Lys Lys Lys Lys Asp 
                805                 810                 815     


Ser Arg Gln Lys Arg Leu Ser Asp Leu Tyr Ala Ala Ile Lys Lys Asp 
            820                 825                 830         


Asp Ala Leu Leu Ser Gly Leu Thr Asn Glu Glu Phe Gly Gly Leu Lys 
        835                 840                 845             


Ser Gly Leu Ala Lys Tyr Asp Asp Ala Ala Leu Arg Ser Lys Lys Leu 
    850                 855                 860                 


Tyr Leu Tyr Tyr Thr Gln Met Gly Arg Cys Ala Tyr Thr Gly Glu Val 
865                 870                 875                 880 


Ile Asp Leu Ser Gln Leu Asn Thr Asp Asn Tyr Asp Ile Asp His Ile 
                885                 890                 895     


Tyr Pro Arg Ser Leu Thr Lys Asp Asp Ser Phe Asp Asn Leu Val Leu 
            900                 905                 910         


Cys Lys Arg Thr Ala Asn Ala Gln Lys Ser Asp Thr Tyr Pro Ile Ser 
        915                 920                 925             


Lys Glu Ile Gln Lys Ala Gln Lys Ala Phe Trp Ile Phe Leu Lys Gln 
    930                 935                 940                 


Gln Gly Leu Ile Ser Glu Arg Lys Tyr Glu Arg Leu Thr Arg Ile Thr 
945                 950                 955                 960 


Pro Leu Thr Ala Asp Asp Leu Ser Gly Phe Ile Ala Arg Gln Leu Val 
                965                 970                 975     


Glu Thr Asn Gln Ser Val Lys Ala Ala Thr Thr Leu Leu Arg Arg Leu 
            980                 985                 990         


Tyr Pro Gly Val Asp Val Val Phe  Val Lys Ala Glu Asn  Val Thr Asp 
        995                 1000                 1005             


Phe Arg  His Asp Asn Asp Phe  Ile Lys Val Arg Ser  Leu Asn His 
    1010                 1015                 1020             


His His  His Ala Lys Asp Ala  Tyr Leu Asn Ile Val  Val Gly Asn 
    1025                 1030                 1035             


Val Tyr  His Glu Arg Phe Thr  Arg Asn Phe Arg Ala  Phe Phe Lys 
    1040                 1045                 1050             


Lys Asn  Gly Ala Asn Arg Thr  Tyr Asn Leu Ala Lys  Met Phe Asn 
    1055                 1060                 1065             


Tyr Asp  Val Lys Cys Thr Asn  Ala Lys Asp Gly Lys  Ala Trp Ala 
    1070                 1075                 1080             


Val Lys  Thr Ser Met Asp Thr  Val Lys Lys Met Met  Asp Ser Asn 
    1085                 1090                 1095             


Asp Val  Arg Val Thr Lys Arg  Val Tyr Glu Gln Lys  Gly Gln Leu 
    1100                 1105                 1110             


Ser Asp  Ile Asn Leu Thr Lys  Ala Ser Lys Val Lys  Ala Asp Ile 
    1115                 1120                 1125             


Tyr Leu  Pro Ile Lys Ala Asn  Asp Pro Ile Met Ser  Gln Asn Met 
    1130                 1135                 1140             


Lys Tyr  Gly Gly Tyr Ser Asp  Ile Lys Asn Ala Tyr  Tyr Thr Ile 
    1145                 1150                 1155             


Ile Glu  Tyr Ser Asp Lys Lys  Asn Asn Ser Ile Lys  Ala Phe Ile 
    1160                 1165                 1170             


Pro Ile  Pro Ile Phe Ile Ala  Thr Lys Thr Leu Thr  Lys Gln Ala 
    1175                 1180                 1185             


Leu Leu  Glu Tyr Ile Lys Thr  Val Leu Pro Lys Ala  Asn Asn Leu 
    1190                 1195                 1200             


Arg Ile  Ile Tyr Lys Lys Val  Tyr Asn Asp Gln Leu  Leu Lys Ile 
    1205                 1210                 1215             


Asp Gly  Phe Asn Tyr Tyr Leu  Gly Gly Arg Ser Asn  Asp Arg Phe 
    1220                 1225                 1230             


Cys Ile  Asp Asn Ala Ile Gln  Leu Ile Val Pro Leu  Glu Ile Gln 
    1235                 1240                 1245             


Phe Tyr  Ile Lys Leu Val Glu  Lys Phe Thr Ala Ile  Ile Ser Glu 
    1250                 1255                 1260             


Asn Lys  Asn Ile Ala Leu Lys  Ala Ser Ser Val Lys  Ser Arg Asn 
    1265                 1270                 1275             


Pro Ile  Asn Asn Gln Val Glu  Asn Ile Thr Leu Glu  Tyr Thr Gln 
    1280                 1285                 1290             


Lys Leu  Phe Asp Tyr Leu Val  Ser Lys Phe Asn Glu  Leu Ile Tyr 
    1295                 1300                 1305             


Leu Lys  Met Arg Gly Asn Lys  Leu Thr Asp Val Asn  Asn Ile Gly 
    1310                 1315                 1320             


Arg Lys  Gln Phe Ile Lys Leu  Ser Leu Glu Glu Arg  Cys Lys Ala 
    1325                 1330                 1335             


Leu Ala  Glu Leu Leu Asn Ile  Phe Thr Asn Met Asn  Lys Lys Leu 
    1340                 1345                 1350             


Ser Leu  Ser Thr Ile Asn Val  Ser Ala Ser Arg Lys  Val Val Asn 
    1355                 1360                 1365             


Phe Lys  Ile Ser Ser Leu Asp  Glu Phe Lys Ile Val  Asn Glu Ser 
    1370                 1375                 1380             


Ile Thr  Gly Leu Tyr Ser His  Glu Ile Thr Ile Val  
    1385                 1390                 1395 


<210> 615
<211> 1120
<212> PRT
<213> Veillonella sp.


<220>
<223> Veillonella sp. oral taxon 780 str. F0422

<400> 615
Met Gly Phe Lys Ala Asn Leu Val Asn Leu Phe Thr Asp Glu Asp Ile 
1               5                   10                  15      


Glu Val Ile Leu Pro Glu Glu Lys Glu Phe Lys Ser Ile Asn Leu His 
            20                  25                  30          


Glu Gly Ile Tyr Glu Asp Val Arg Asp Ala Tyr Glu Asp Ala Trp Gly 
        35                  40                  45              


Asp Arg Phe Ala Ile Val Asp Gln Cys Lys Val Leu His Asp Ile Ile 
    50                  55                  60                  


Val Ile Ser Ser Ile Ile Lys Pro Gly Gln Ser Leu Ser Glu Ala Lys 
65                  70                  75                  80  


Ile Glu Ser Tyr Asn Gln His Lys Glu Asp Leu Val Leu Leu Lys Ser 
                85                  90                  95      


Val Leu Lys Glu Asp Arg Lys Leu Tyr Asp Asp Met Phe Val Val Asp 
            100                 105                 110         


Thr Asp Lys Gly Thr Asn Tyr Val Lys Tyr Thr Lys Gln Gly Val Asn 
        115                 120                 125             


Gly Asn Thr Ser Ala Thr Gln Glu Glu Phe Tyr Lys Tyr Val Arg Lys 
    130                 135                 140                 


Val Val Ser Val Leu Pro Glu Thr Glu His Thr Arg Arg Ile Val Gln 
145                 150                 155                 160 


Lys Leu Glu Glu Gly Thr Phe Leu Pro Leu Gln Arg Ile Ser Lys Asn 
                165                 170                 175     


Gly Val Val Pro Tyr Gln Leu His Lys Glu Glu Leu Val Arg Ile Leu 
            180                 185                 190         


Asp Lys Ala Thr Val Asn Phe Pro Phe Leu Asn Lys Val Glu Asn Gly 
        195                 200                 205             


Leu Thr Val Ala Asp Lys Ile Ile Ser Ile Leu Glu Phe Lys Ile Pro 
    210                 215                 220                 


Tyr Tyr Val Gly Pro Leu Asn Pro Thr His Ser Ile Glu Asn Gly Gly 
225                 230                 235                 240 


Phe Ala Trp Val Val Arg Lys Glu Ala Gly Gln Val Leu Pro Trp Asn 
                245                 250                 255     


Phe Glu Gln Lys Val Asp Val Gln Ala Ser Ala Val Lys Phe Ile Glu 
            260                 265                 270         


Asn Leu Thr Asn Lys Cys Thr Tyr Leu Ile Asp Gln Asp Val Leu Pro 
        275                 280                 285             


Lys Tyr Ser Leu Leu Tyr Ala Glu Phe Ser Leu Leu Asn Glu Leu Asn 
    290                 295                 300                 


Asn Ile Arg Val Asn Asp Lys Pro Leu Pro Ala Asp Val Lys Gln Ala 
305                 310                 315                 320 


Phe Ile Arg Asp His Phe Ile Ser Leu Gln Asp Ser Lys Thr Ala Thr 
                325                 330                 335     


Lys Lys Val Val Ala Lys Tyr Leu Val Asp Asn Asn Tyr Val Ser Gln 
            340                 345                 350         


Pro Pro Ile Ile Thr Gly Met Asp Gln Gln Ile Ala Thr Lys Leu Thr 
        355                 360                 365             


Ser His Arg Asp Met Thr Arg Ile Leu Gly Glu His Phe Asp His Ala 
    370                 375                 380                 


Met Ala Glu Asp Ile Ile Arg Tyr Ile Thr Ile Phe Gly Glu Ser Lys 
385                 390                 395                 400 


Asp Met Leu Arg Gln Val Leu Lys Asn Tyr Tyr Gly Asp Arg Leu Thr 
                405                 410                 415     


Thr Glu Gln Ile Lys Lys Leu Gly Lys Leu Thr Tyr Thr Gly Trp Gly 
            420                 425                 430         


Arg Leu Ser Lys Lys Phe Leu Ser Asp Ile Trp Gly Met Lys Lys Asn 
        435                 440                 445             


Asp Asp Asp Ala Glu Ala Gly Thr Ile Ile Glu His Met Arg Glu Gly 
    450                 455                 460                 


Gln Glu Asn Leu Met Gln Leu Leu Ser Ser Ser Tyr Ser Phe Ile Asp 
465                 470                 475                 480 


Val Val Gln Glu Tyr Val Thr Asn Val Leu Gly Glu Lys Glu Lys Thr 
                485                 490                 495     


Ala Phe Glu Met Leu Glu Asp Leu Ser Leu Ser Pro Met Val Lys Arg 
            500                 505                 510         


Ser Val Trp Gln Thr Leu Arg Ile Leu Asp Glu Ile Val Ser Ile Arg 
        515                 520                 525             


Lys Glu Leu Pro Lys Lys Ile Phe Val Glu Val Ala Arg Thr Asn Lys 
    530                 535                 540                 


Ala Asp Lys Lys Arg Thr Gln Ser Arg Lys Ala Leu Leu Glu Glu Leu 
545                 550                 555                 560 


Tyr Lys Gln Ile Lys Asp Glu Asp Val His Val Leu Gln Gln Glu Leu 
                565                 570                 575     


Glu Ser Lys Glu Asp Ser Ala Leu Asn Ser Lys Lys Leu Tyr Leu Tyr 
            580                 585                 590         


Phe Thr Gln Met Gly Arg Cys Met Tyr Ser Gly Arg Arg Ile Asp Ile 
        595                 600                 605             


His Glu Leu Phe Thr Asp Lys Tyr Asp Ile Asp His Ile Tyr Pro Arg 
    610                 615                 620                 


Ser Leu Thr Lys Asp Asp Ser Trp His Asn Ile Val Leu Val Glu Lys 
625                 630                 635                 640 


Gln Leu Asn Ala Glu Lys Thr Asp Arg Phe Pro Ile Leu Ser Ala Ile 
                645                 650                 655     


Gln Ser Lys Gln Lys Gly Phe Trp Lys Leu Leu Trp Asp Arg Gly Phe 
            660                 665                 670         


Ile Ser Glu Lys Lys Tyr Asp Arg Leu Val Arg Thr Thr Asp Leu Thr 
        675                 680                 685             


Asp Glu Glu Leu Asn Gln Phe Ile Asn Arg Gln Met Val Ser Thr Asn 
    690                 695                 700                 


Gln Ser Val Lys Ala Val Thr Thr Leu Leu His Gln Leu Tyr Pro Glu 
705                 710                 715                 720 


Thr Glu Val Val Phe Ser Lys Ala Glu Asn Val Ser Asp Phe Arg His 
                725                 730                 735     


Asp Tyr Asp Phe Val Lys Val Arg Ser Ile Asn His His His His Ala 
            740                 745                 750         


Lys Asp Ala Tyr Leu Asn Ile Val Val Gly Asn Val Tyr His Glu Lys 
        755                 760                 765             


Phe Thr Lys Asn Phe Leu Ser Phe Ala Lys Gln Lys Gly Thr Arg Arg 
    770                 775                 780                 


Thr Tyr Asn Leu Thr Lys Ile Phe Glu Tyr Glu Ile Lys Leu Thr Glu 
785                 790                 795                 800 


Glu Ser Lys Lys Val Ile Trp Asp Pro Asn Ile His Met Asp Ile Val 
                805                 810                 815     


Lys Lys Met Met Lys Ser Asn Asp Val Arg Val Thr Gln Arg Ala Val 
            820                 825                 830         


Pro Gln Lys Gly Gly Leu Ser Asp Glu Thr Ile Tyr Lys Lys Gly Ile 
        835                 840                 845             


Ala Lys Arg Gly Val Tyr Leu Pro Leu Lys Ser Ser Asp Glu Arg Val 
    850                 855                 860                 


Arg Asp Val Glu Lys Tyr Gly Gly Arg Thr Ser Ile Thr Ile Ser Glu 
865                 870                 875                 880 


Tyr Ile Ile Leu Asn Ile Arg Asp Thr Ser Asp Gln Asp Arg Ile Glu 
                885                 890                 895     


Ile Phe Ser Leu Pro Leu Tyr Ile Ala Gly Lys Lys Asp Ile His Lys 
            900                 905                 910         


Ala Ile Glu Glu Ala Tyr Leu Ser Thr Cys Lys Lys Pro Ala Ser Val 
        915                 920                 925             


Val Asp Ile Gln Ile Leu Tyr Arg Gly Leu Tyr Ile Gly Ser Lys Val 
    930                 935                 940                 


Asn Ile Asn Gly Phe Thr Tyr Tyr Met Gly Gly Lys Thr Gly Ser Asn 
945                 950                 955                 960 


Val Ser Ile Asp Ser Ala Val Asp Val Val Met Asp Ile Thr Ser Ser 
                965                 970                 975     


Val Tyr Ile Lys Leu Leu Glu Lys Val Ala Ile Lys Lys Ile Glu Asn 
            980                 985                 990         


Pro Lys Thr Phe Arg Ile Glu Asn  Ile Lys Thr Ser Tyr  Asn His Lys 
        995                 1000                 1005             


Glu Val  Thr Val Ser Lys Glu  Gln Asn Ile Ala Leu  Tyr Gln Glu 
    1010                 1015                 1020             


Leu Leu  Lys Lys Leu Asp Thr  Pro Leu Phe Ser Lys  Met Lys Gly 
    1025                 1030                 1035             


Asn Lys  Leu Glu Glu Phe Arg  Thr Val Gly Phe Asp  Thr Phe Ile 
    1040                 1045                 1050             


Ala Leu  Ser Leu Glu Glu Gln  Ala Ser Val Leu Leu  Glu Val Leu 
    1055                 1060                 1065             


Asn Val  Leu Thr Asn Phe Lys  Thr Lys Arg Asp Ile  Thr Lys Ile 
    1070                 1075                 1080             


Gly Met  Thr Ser Ser Arg Ser  Thr Leu Gly Ile Asn  Ile Ser Asn 
    1085                 1090                 1095             


Thr Glu  Gln Phe Ser Val Ile  Thr Thr Ser Ile Thr  Gly Leu Tyr 
    1100                 1105                 1110             


Glu Gln  Glu Ile Lys Ile Lys  
    1115                 1120 


<210> 616
<211> 1068
<212> PRT
<213> Verminephrobacter eiseniae

<400> 616
Met Asn Lys Ala Val Ala Tyr Arg Leu Ala Leu Asp Leu Gly Ser Thr 
1               5                   10                  15      


Ser Leu Gly Trp Ala Ile Phe Arg Leu Asn Glu Ala Arg Glu Pro Thr 
            20                  25                  30          


Ala Ile Ile Arg Ala Gly Val Arg Ile Phe Ser Asp Gly Arg Asn Ala 
        35                  40                  45              


Asn Ser Glu Pro Leu Ala Val His Arg Arg Val Ala Arg Ala Met Arg 
    50                  55                  60                  


Arg Arg Arg Asp Arg Leu Leu Lys Arg Lys Lys Arg Met His Asp Gln 
65                  70                  75                  80  


Leu Val Gln His Gly Phe Phe Pro Ala Glu Val Ala Glu Arg Lys Glu 
                85                  90                  95      


Leu Glu Arg Leu Asn Pro Tyr Gln Leu Arg Ala Lys Gly Leu His Glu 
            100                 105                 110         


Ala Leu Thr Pro Gly Glu Phe Ala Arg Ala Leu Phe His Ile Asn Gln 
        115                 120                 125             


Arg Arg Gly Phe Lys Ser Asn Arg Lys Thr Asp Arg Lys Asp Asn Asp 
    130                 135                 140                 


Ser Gly Ala Leu Lys Gln Ala Ile Ser Glu Leu Arg Lys Arg Ile Gln 
145                 150                 155                 160 


Asp Ser Asp Cys Ala Thr Ala Gly Glu Trp Phe Trp Lys Glu Arg Met 
                165                 170                 175     


Gln Gln Lys Pro Glu Gly Val Arg Gly Gln Trp Val Arg Ala Arg Tyr 
            180                 185                 190         


Arg Lys Thr Pro Ser Thr Thr Asp Glu Gly Lys Lys Arg Ile Gly Tyr 
        195                 200                 205             


Asp Leu Tyr Val Asp Arg Ala Met Val Glu Gln Glu Phe Asp Ala Leu 
    210                 215                 220                 


Trp Ala Ala Gln Ala Ala Leu Gln Pro Gly Leu Phe Thr Glu Ala Ala 
225                 230                 235                 240 


Arg Ala Glu Leu Lys Asp Thr Leu Leu Tyr Gln Arg Asp Leu Arg Pro 
                245                 250                 255     


Val Lys Pro Gly Arg Cys Thr Leu Leu Pro Ala Glu Glu Arg Ala Pro 
            260                 265                 270         


Leu Ala Leu Pro Ser Thr Gln Arg Phe Arg Ile Leu Gln Glu Val Asn 
        275                 280                 285             


Asn Leu Arg Leu Leu Asp Glu Ala Leu Arg Glu Val Pro Leu Asn Leu 
    290                 295                 300                 


Ala Gln Arg Asp Ala Val Val Ser Ala Leu Glu Gly Lys Lys Glu Leu 
305                 310                 315                 320 


Ser Phe Ala Ala Ile Arg Lys Leu Leu Thr Leu Ser Gly Lys Phe Asn 
                325                 330                 335     


Leu Glu Asp Glu Lys Arg Ala Glu Leu Lys Gly Asn Ala Thr Ser Val 
            340                 345                 350         


Ile Leu Ala Arg Lys Asp Leu Phe Gly Asp Ala Trp Ala Gly Phe Asp 
        355                 360                 365             


Ala Ala Val Gln Asp Glu Ile Val Trp Arg Leu Val Ser Gln Glu Ser 
    370                 375                 380                 


Glu Gly Ala Leu Ile Ala Trp Leu Gln Gln His Thr Gly Val Asp Gly 
385                 390                 395                 400 


Val Cys Ala Glu Ala Ile Val Asn Thr Arg Leu Pro Asp Gly Tyr Gly 
                405                 410                 415     


Arg Leu Ser Arg Lys Ala Leu Glu Arg Ile Val Pro Ala Leu Gln Arg 
            420                 425                 430         


Glu Val Cys Thr Tyr Asp Lys Ala Val Gln Ala Ala Gly Phe Ala His 
        435                 440                 445             


His Ser Asp Leu Gly Phe Asp Phe Asp Tyr Ala Glu Asp Glu Val Gln 
    450                 455                 460                 


Gln Val Gly Glu His Thr Ile Ala Ser Thr Gly Glu Val Gln Ala Gln 
465                 470                 475                 480 


Tyr Ala Phe Lys Gln Leu Pro Tyr Tyr Gly Lys Ala Leu Gln Arg His 
                485                 490                 495     


Val Ala Phe Gly Ser Gly Asp Ala Lys Asp His Glu Glu Lys Cys Tyr 
            500                 505                 510         


Gly Lys Ile Ala Asn Pro Thr Val His Ile Gly Leu Asn Gln Val Arg 
        515                 520                 525             


Thr Val Val Asn Ala Leu Ile Arg Arg Tyr Gly His Pro Thr Glu Val 
    530                 535                 540                 


Val Val Glu Leu Ala Arg Asp Leu Lys Gln Ser Arg Glu Gln Lys Gln 
545                 550                 555                 560 


Gln Thr Gln Arg Glu Gln Ala Asp Asn Gln Lys Arg Asn Glu Asp Ile 
                565                 570                 575     


Arg Lys Arg Ile Ala Pro Ile Leu Glu Thr Ser Pro Glu Arg Val Arg 
            580                 585                 590         


Asp Arg Asp Ile Lys Lys Trp Ile Leu Trp Glu Glu Leu Asn Lys Lys 
        595                 600                 605             


Asp Ile Ala Asp Arg His Cys Pro Tyr Ser Gly Glu Arg Ile Ser Ala 
    610                 615                 620                 


Thr Met Leu Leu Ser Glu Ala Val Glu Ile Glu His Ile Leu Pro Phe 
625                 630                 635                 640 


Ser Arg Thr Leu Asp Asp Ser Leu Asn Asn Arg Thr Val Ala Met Arg 
                645                 650                 655     


Arg Ala Asn Arg Ile Lys Gly Asp Arg Thr Pro Trp Glu Ala Arg Ala 
            660                 665                 670         


Asp Phe Glu Ala Gln Gly Trp Arg Tyr Glu Ala Ile Leu Gln Arg Ala 
        675                 680                 685             


Glu Gly Met Pro Pro Arg Lys Arg Tyr Arg Phe Ala Glu Asp Gly Tyr 
    690                 695                 700                 


Gln Arg Trp Leu Gly Lys Asp Arg Asn Phe Leu Ala Arg Ala Leu Asn 
705                 710                 715                 720 


Asp Thr Ser Tyr Leu Ser Arg Leu Ala Ala Asn Tyr Leu Arg Leu Val 
                725                 730                 735     


Cys Pro Gln Gly Val Arg Val Ile Pro Gly Gln Met Thr Asp Lys Leu 
            740                 745                 750         


Arg Gly Lys Phe Gly Leu Asn Ser Val Leu Gly Leu Asp Gly Lys Lys 
        755                 760                 765             


Asn Arg Asn Asp His Arg His His Ala Val Asp Ala Cys Val Ile Gly 
    770                 775                 780                 


Val Thr Asp Gln Gly Leu Met Gln Arg Phe Ala Asn Ala Ser Lys Gln 
785                 790                 795                 800 


Ala Arg Glu Asn Gly Leu Thr Arg Leu Val Gln Asp Met Leu Leu Pro 
                805                 810                 815     


Trp Trp Pro Ser Tyr Tyr Asp His Val Glu Arg Ala Val Arg His Ile 
            820                 825                 830         


Arg Val Ser His Arg Pro Asp His Gly Phe Glu Gly Ala Met Met Lys 
        835                 840                 845             


Gly Thr Ala His Gly Ile Arg Glu Asp Gly Ile Arg Glu Asp Gly Arg 
    850                 855                 860                 


Ile Lys Gln Arg Pro Lys Ala Lys Gly Ser Ala Asp His Lys Thr Ile 
865                 870                 875                 880 


Thr Leu Ile Pro Ile Asp Glu Pro Arg Gln Leu Ala Arg His Gly Val 
                885                 890                 895     


Asp Ala Glu Gly Lys Pro Leu Pro Tyr Lys Gly Tyr Ala Ser Gly Ser 
            900                 905                 910         


Asn Tyr Cys Ile Glu Ile Thr Lys Asn Gly Lys Gly Lys Trp Glu Gly 
        915                 920                 925             


Gln Val Ile Ser Thr Phe Asp Ala Tyr Arg Ile Lys Ala Ala Ala Asp 
    930                 935                 940                 


Ala Ala Ala Arg Ala Gly Gln Val Ile Ser Thr Val Glu Ala Asp Ser 
945                 950                 955                 960 


Ile Val Arg Lys Ser Gly Trp Glu Arg Leu Arg Gly Ala Gln Ser Gln 
                965                 970                 975     


Asn Gly Gln Pro Leu Val Met Arg Leu Val Ile Gly Asp Ser Val Arg 
            980                 985                 990         


Met Glu Val Asp Gly Arg Asp Glu  Val Met Arg Val Val  Lys Met Ser 
        995                 1000                 1005             


Gly Lys  Glu Met Val Phe Ala  Pro Val Arg Glu Ala  Asn Val Asp 
    1010                 1015                 1020             


Lys Arg  Asn Asn Met Pro Asp  Glu Gln Asp Pro Phe  Thr Tyr Thr 
    1025                 1030                 1035             


Tyr Lys  Arg Ala Asp Gln Leu  Arg Lys Ala Lys Ala  Arg Gln Val 
    1040                 1045                 1050             


Thr Ile  Ser Pro Ile Gly Glu  Leu Arg Asp Pro Gly  Phe Lys Gly 
    1055                 1060                 1065             


<210> 617
<211> 1440
<212> PRT
<213> Weeksella virosa

<400> 617
Met Lys Thr Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Glu Gln Asp Phe Glu Asn Lys Gln Gly Leu Ile Leu Gly 
            20                  25                  30          


Met Gly Ser Arg Ile Ile Pro Met Asp Ala Gly Ile Ile Gly Lys Phe 
        35                  40                  45              


Ala Glu Gly Ser Ser Ile Ser Gln Thr Ala Glu Arg Thr Gly Tyr Arg 
    50                  55                  60                  


Ser Ile Arg Arg Leu Arg Glu Arg His Leu Leu Arg Arg Glu Arg Leu 
65                  70                  75                  80  


His Arg Val Leu Asn Ile Leu Lys Phe Leu Pro Glu His Tyr Ala Ala 
                85                  90                  95      


Glu Ile Asp Phe Glu Lys Arg Phe Gly Gln Phe Leu Ala Glu Thr Glu 
            100                 105                 110         


Pro Lys Leu Ala Trp Lys Lys Asn Ala Glu Gly Lys Phe Glu Phe Leu 
        115                 120                 125             


Phe Gln Arg Ser Phe Asp Glu Met Val Ala Asp Phe Lys Ala Asn Gly 
    130                 135                 140                 


Gln Asp Ile Lys Ile Pro Tyr Asp Trp Thr Ile Tyr Tyr Leu Arg Lys 
145                 150                 155                 160 


Lys Ala Leu Thr Gln Lys Ile Ser Pro Gln Glu Leu Ala Trp Ile Ile 
                165                 170                 175     


Leu Asn Phe Asn Gln Lys Arg Gly Tyr Tyr Gln Leu Arg Gly Glu Glu 
            180                 185                 190         


Glu Glu Glu Asn Pro Asn Lys Lys Val Glu Phe Tyr Ser Leu Lys Ile 
        195                 200                 205             


Val Asp Val Val Ala Asp Glu Gln Pro Asn Lys Lys Gly Asp Thr Trp 
    210                 215                 220                 


Tyr Ser Leu His Leu Glu Asn Gly Trp Val Tyr Arg Arg Ser Ser Lys 
225                 230                 235                 240 


Ile Pro Leu Tyr Asp Trp Lys Asp Lys Val Arg Asp Phe Ile Val Thr 
                245                 250                 255     


Thr Asp Ile Asn Glu Asp Gly Ser Glu Lys Leu Asp Lys Asp Gly Glu 
            260                 265                 270         


Val Lys Arg Ser Phe Arg Ala Pro Lys Glu Asp Asp Trp Thr Leu Ile 
        275                 280                 285             


Lys Lys Lys Thr Glu Gln Glu Ile Glu Gln Phe Asn Gln Thr Val Gly 
    290                 295                 300                 


Ser Tyr Ile Tyr Glu Ala Leu Leu Asp Asn Pro Thr Gln Lys Ile Arg 
305                 310                 315                 320 


Gly Lys Leu Val Arg Thr Ile Glu Arg Lys Phe Tyr Lys Ser Glu Leu 
                325                 330                 335     


Lys Lys Ile Leu Glu Lys Gln Ile Glu Leu Gln Pro Glu Leu Phe Thr 
            340                 345                 350         


Glu Asp Leu Tyr Asn Ala Cys Ala Arg Glu Leu Tyr Arg Arg Asn Val 
        355                 360                 365             


Ala His Gln Gln Gln Leu Ser Ser Arg Asp Phe Val Tyr Leu Phe Leu 
    370                 375                 380                 


Asn Asp Ile Ile Phe Tyr Gln Arg Pro Leu Arg Ser Gln Lys Ser Leu 
385                 390                 395                 400 


Ile Ser Asn Cys Ser Leu Glu Phe Arg Thr Ile Lys Asp Lys Asp Gly 
                405                 410                 415     


Asn Gly Gln Ile Ile Tyr Leu Lys Ala Ile Pro Lys Ser Asn Pro Tyr 
            420                 425                 430         


Tyr Gln Glu Phe Arg Val Trp Gln Trp Leu Tyr Asn Leu Lys Ile Phe 
        435                 440                 445             


Thr Lys Glu Asp Asp Lys Asp Val Thr Asn Gln Phe Ile Asn Lys Val 
    450                 455                 460                 


Glu Asp Leu Glu Ala Leu Phe Glu Phe Leu Met Asn Gln Lys Glu Val 
465                 470                 475                 480 


Asn His Thr Asp Ile Leu Thr Tyr Leu Ile Glu Pro Ile Val Lys Ser 
                485                 490                 495     


Lys Tyr Pro Asn Ala Lys Gly Lys Ala Phe Lys Asp Glu Leu Lys Lys 
            500                 505                 510         


Glu Leu Lys Lys Tyr Arg Trp Asn Tyr Val Tyr Asp Ala Asp Lys Asp 
        515                 520                 525             


Glu Ser Lys Ser Tyr Pro Met Asn Glu Thr Arg Tyr Glu Leu Arg Lys 
    530                 535                 540                 


Arg Leu Asp Lys Val Glu Asn Val Pro Ala Asp Phe Met Thr Arg Lys 
545                 550                 555                 560 


Ile Glu Gln His Leu Trp His Ile Ile Tyr Ser Val Thr Asp Lys Ile 
                565                 570                 575     


Glu Phe Glu Lys Ala Leu Lys Ser Phe Ala Asn Lys Tyr Asp Leu His 
            580                 585                 590         


Gln Glu Ser Phe Val Glu Asn Phe Lys Arg Phe Lys Pro Phe Asp Ser 
        595                 600                 605             


Asp Tyr Gly Thr Tyr Ser Glu Lys Ala Ile Lys Lys Leu Leu Pro Leu 
    610                 615                 620                 


Met Arg Val Gly Lys Tyr Trp Ser Trp Asp Ile Ile Asp Asp Lys Thr 
625                 630                 635                 640 


Lys Thr Arg Ile Gly Lys Ile Ile Thr Gly Glu Tyr Asp Glu Thr Ile 
                645                 650                 655     


Lys Asn Arg Val Arg Glu Lys Ala Ile Asp Leu Thr Glu Glu Asn His 
            660                 665                 670         


Phe Gln Gly Leu Gln Leu Trp Leu Ala Gln Tyr Ile Val Tyr Asp Arg 
        675                 680                 685             


His Ser Glu Ala Asp Ile Ala Gly Lys Trp Asn Ser Val Ala Asp Leu 
    690                 695                 700                 


Glu Gln Tyr Leu Ser Glu Phe Lys Gln His Ser Leu Arg Asn Pro Ile 
705                 710                 715                 720 


Val Glu Gln Val Ile Thr Glu Thr Leu Arg Val Val Arg Asp Ile Trp 
                725                 730                 735     


Lys Gln Tyr Gly Lys Gly Ala Lys Asp Tyr Phe Asp Glu Ile His Ile 
            740                 745                 750         


Glu Leu Gly Arg Glu Met Lys Asn Thr Ala Glu Glu Arg Lys Arg Leu 
        755                 760                 765             


Ser Ser Ile Ile Ser Glu Asn Glu Thr Thr Asn Leu Arg Ile Arg Ala 
    770                 775                 780                 


Ile Leu Glu Glu Leu Met Tyr Asp Glu Asn Met Glu Asn Val Arg Pro 
785                 790                 795                 800 


Tyr Ser Pro Met Gln Gln Glu Ala Leu Lys Ile Tyr Glu Asp Gly Val 
                805                 810                 815     


Leu Ser Ser Ser Val Glu Ile Pro Glu Asp Ile Glu Lys Ile Ser Lys 
            820                 825                 830         


Lys Ser Glu Pro Thr Lys Ser Glu Ile Gln Arg Tyr Lys Leu Trp Leu 
        835                 840                 845             


Glu Gln Lys Tyr Arg Ser Pro Tyr Thr Gly Arg Pro Ile Pro Leu Ser 
    850                 855                 860                 


Lys Leu Phe Thr Pro Ala Tyr Gln Ile Glu His Ile Ile Pro Gln Ala 
865                 870                 875                 880 


Arg Phe Phe Asp Asp Gly Phe Ser Asn Lys Val Ile Cys Glu Ser Glu 
                885                 890                 895     


Val Asn Ala Leu Lys Asp Lys Met Leu Gly Leu Glu Phe Ile Gln Asn 
            900                 905                 910         


Tyr Tyr Gly Gln Lys Val Thr Thr Ser Phe Gly Glu Val Thr Ile Leu 
        915                 920                 925             


Thr Glu Asp Ala Tyr Lys Ala Phe Val Lys Glu His Tyr Asp Lys Asn 
    930                 935                 940                 


Arg Ser Lys Arg Asn Lys Leu Leu Leu Glu Glu Ile Pro Glu Lys Met 
945                 950                 955                 960 


Ile Asp Arg Gln Met Asn Asp Thr Arg Tyr Ile Ser Lys Tyr Ile Ser 
                965                 970                 975     


Lys Val Leu Ser Asn Leu Val Arg Gly Glu Lys Asp Asp Glu Gly Val 
            980                 985                 990         


Asn Ser Lys Asn Ile Ile Pro Gly  Asn Gly Lys Ile Thr  Gly Ile Leu 
        995                 1000                 1005             


Lys Gln  Asp Trp Gly Leu Asn  Asp Val Trp Asn Asp  Leu Ile Leu 
    1010                 1015                 1020             


Pro Arg  Phe Glu Arg Met Asn  Gln Leu Thr Asn Ser  Thr Asp Phe 
    1025                 1030                 1035             


Thr Ala  Trp Asn Glu Lys His  Gln Lys Phe Leu Pro  Ser Val Pro 
    1040                 1045                 1050             


Leu Glu  Leu Ser Lys Gly Phe  Gln Lys Lys Arg Ile  Asp His Arg 
    1055                 1060                 1065             


His His  Ala Leu Asp Ala Leu  Ile Ile Ala Cys Ala  Thr Arg Asp 
    1070                 1075                 1080             


His Val  Asn Leu Leu Asn Asn  Lys His Ala Lys Ser  Arg Asn Glu 
    1085                 1090                 1095             


Arg Tyr  Asp Leu Gln His Lys  Leu Arg His Thr Thr  Pro Trp Gln 
    1100                 1105                 1110             


Asp Lys  Glu Gly Lys Val Arg  Thr Lys Phe Thr Glu  Phe Lys Lys 
    1115                 1120                 1125             


Pro Trp  Glu Thr Phe Thr Gln  Asp Thr Lys Lys Glu  Leu Glu Lys 
    1130                 1135                 1140             


Ile Val  Val Asn Phe Lys Gln  Asn Leu Arg Val Ile  Asn Lys Ala 
    1145                 1150                 1155             


Thr Asn  Tyr Tyr Glu Lys Ile  Val Asp Gly Lys Lys  Val Met Phe 
    1160                 1165                 1170             


Lys Gln  Glu Gly Val Asn Trp  Ala Ile Arg Lys Pro  Met His Lys 
    1175                 1180                 1185             


Glu Thr  Val Ser Gly Lys Ile  Asp Leu Pro Arg Val  Lys Val Ser 
    1190                 1195                 1200             


Lys Gly  Lys Ile Leu Thr Ala  Thr Arg Lys Ser Leu  Asp Thr Ser 
    1205                 1210                 1215             


Phe Asn  Ala Lys Thr Ile Leu  Ser Ile Thr Asp Thr  Gly Ile Gln 
    1220                 1225                 1230             


Lys Ile  Leu Leu Asn Tyr Leu  Lys Ala Lys Gly Asn  Pro Glu Leu 
    1235                 1240                 1245             


Ala Phe  Ser Pro Glu Gly Ile  Glu Glu Met Asn Gln  Asn Ile Ser 
    1250                 1255                 1260             


Leu Tyr  Asn Asp Gly Lys Pro  His Gln Pro Ile Leu  Lys Val Arg 
    1265                 1270                 1275             


Val Phe  Glu Gln Gly Ser Lys  Phe Pro Leu Gly Glu  Thr Gly Asn 
    1280                 1285                 1290             


Lys Thr  Thr Lys Tyr Val Glu  Ala Ala Lys Gly Thr  Asn Leu Phe 
    1295                 1300                 1305             


Phe Gly  Val Tyr Glu Asp Asn  Gln Gly Lys Arg Ser  Tyr Asp Thr 
    1310                 1315                 1320             


Ile Pro  Leu Asn Ile Val Ile  Glu Arg Gln Lys Gln  Gly Leu Asn 
    1325                 1330                 1335             


Ser Val  Pro Glu Thr Asn Glu  Lys Gly His Arg Leu  Leu Phe Ser 
    1340                 1345                 1350             


Leu Ser  Pro Asn Asp Leu Val  Tyr Val Pro Ile Glu  Gly Glu Val 
    1355                 1360                 1365             


Phe Asp  Glu Thr Asn Pro Asp  Val Asn Arg Ile Tyr  Lys Val Val 
    1370                 1375                 1380             


Ser Phe  Ser Gly Ser Gln Met  Phe Cys Val Arg Gln  Asp Val Ala 
    1385                 1390                 1395             


Thr Ser  Ile Val Tyr Lys Leu  Glu Phe Ser Ser Leu  Asn Lys Met 
    1400                 1405                 1410             


Glu Arg  Thr Ile Asp Gly Ile  Met Ile Lys Glu Ile  Cys Ile Lys 
    1415                 1420                 1425             


Leu Lys  Val Asp Arg Leu Gly  Asn Ile Ser Lys Ala  
    1430                 1435                 1440 


<210> 618
<211> 1409
<212> PRT
<213> Wolinella succinogenes

<400> 618
Met Leu Val Ser Pro Ile Ser Val Asp Leu Gly Gly Lys Asn Thr Gly 
1               5                   10                  15      


Phe Phe Ser Phe Thr Asp Ser Leu Asp Asn Ser Gln Ser Gly Thr Val 
            20                  25                  30          


Ile Tyr Asp Glu Ser Phe Val Leu Ser Gln Val Gly Arg Arg Ser Lys 
        35                  40                  45              


Arg His Ser Lys Arg Asn Asn Leu Arg Asn Lys Leu Val Lys Arg Leu 
    50                  55                  60                  


Phe Leu Leu Ile Leu Gln Glu His His Gly Leu Ser Ile Asp Val Leu 
65                  70                  75                  80  


Pro Asp Glu Ile Arg Gly Leu Phe Asn Lys Arg Gly Tyr Thr Tyr Ala 
                85                  90                  95      


Gly Phe Glu Leu Asp Glu Lys Lys Lys Asp Ala Leu Glu Ser Asp Thr 
            100                 105                 110         


Leu Lys Glu Phe Leu Ser Glu Lys Leu Gln Ser Ile Asp Arg Asp Ser 
        115                 120                 125             


Asp Val Glu Asp Phe Leu Asn Gln Ile Ala Ser Asn Ala Glu Ser Phe 
    130                 135                 140                 


Lys Asp Tyr Lys Lys Gly Phe Glu Ala Val Phe Ala Ser Ala Thr His 
145                 150                 155                 160 


Ser Pro Asn Lys Lys Leu Glu Leu Lys Asp Glu Leu Lys Ser Glu Tyr 
                165                 170                 175     


Gly Glu Asn Ala Lys Glu Leu Leu Ala Gly Leu Arg Val Thr Lys Glu 
            180                 185                 190         


Ile Leu Asp Glu Phe Asp Lys Gln Glu Asn Gln Gly Asn Leu Pro Arg 
        195                 200                 205             


Ala Lys Tyr Phe Glu Glu Leu Gly Glu Tyr Ile Ala Thr Asn Glu Lys 
    210                 215                 220                 


Val Lys Ser Phe Phe Asp Ser Asn Ser Leu Lys Leu Thr Asp Met Thr 
225                 230                 235                 240 


Lys Leu Ile Gly Asn Ile Ser Asn Tyr Gln Leu Lys Glu Leu Arg Arg 
                245                 250                 255     


Tyr Phe Asn Asp Lys Glu Met Glu Lys Gly Asp Ile Trp Ile Pro Asn 
            260                 265                 270         


Lys Leu His Lys Ile Thr Glu Arg Phe Val Arg Ser Trp His Pro Lys 
        275                 280                 285             


Asn Asp Ala Asp Arg Gln Arg Arg Ala Glu Leu Met Lys Asp Leu Lys 
    290                 295                 300                 


Ser Lys Glu Ile Met Glu Leu Leu Thr Thr Thr Glu Pro Val Met Thr 
305                 310                 315                 320 


Ile Pro Pro Tyr Asp Asp Met Asn Asn Arg Gly Ala Val Lys Cys Gln 
                325                 330                 335     


Thr Leu Arg Leu Asn Glu Glu Tyr Leu Asp Lys His Leu Pro Asn Trp 
            340                 345                 350         


Arg Asp Ile Ala Lys Arg Leu Asn His Gly Lys Phe Asn Asp Asp Leu 
        355                 360                 365             


Ala Asp Ser Thr Val Lys Gly Tyr Ser Glu Asp Ser Thr Leu Leu His 
    370                 375                 380                 


Arg Leu Leu Asp Thr Ser Lys Glu Ile Asp Ile Tyr Glu Leu Arg Gly 
385                 390                 395                 400 


Lys Lys Pro Asn Glu Leu Leu Val Lys Thr Leu Gly Gln Ser Asp Ala 
                405                 410                 415     


Asn Arg Leu Tyr Gly Phe Ala Gln Asn Tyr Tyr Glu Leu Ile Arg Gln 
            420                 425                 430         


Lys Val Arg Ala Gly Ile Trp Val Pro Val Lys Asn Lys Asp Asp Ser 
        435                 440                 445             


Leu Asn Leu Glu Asp Asn Ser Asn Met Leu Lys Arg Cys Asn His Asn 
    450                 455                 460                 


Pro Pro His Lys Lys Asn Gln Ile His Asn Leu Val Ala Gly Ile Leu 
465                 470                 475                 480 


Gly Val Lys Leu Asp Glu Ala Lys Phe Ala Glu Phe Glu Lys Glu Leu 
                485                 490                 495     


Trp Ser Ala Lys Val Gly Asn Lys Lys Leu Ser Ala Tyr Cys Lys Asn 
            500                 505                 510         


Ile Glu Glu Leu Arg Lys Thr His Gly Asn Thr Phe Lys Ile Asp Ile 
        515                 520                 525             


Glu Glu Leu Arg Lys Lys Asp Pro Ala Glu Leu Ser Lys Glu Glu Lys 
    530                 535                 540                 


Ala Lys Leu Arg Leu Thr Asp Asp Val Ile Leu Asn Glu Trp Ser Gln 
545                 550                 555                 560 


Lys Ile Ala Asn Phe Phe Asp Ile Asp Asp Lys His Arg Gln Arg Phe 
                565                 570                 575     


Asn Asn Leu Phe Ser Met Ala Gln Leu His Thr Val Ile Asp Thr Pro 
            580                 585                 590         


Arg Ser Gly Phe Ser Ser Thr Cys Lys Arg Cys Thr Ala Glu Asn Arg 
        595                 600                 605             


Phe Arg Ser Glu Thr Ala Phe Tyr Asn Asp Glu Thr Gly Glu Phe His 
    610                 615                 620                 


Lys Lys Ala Thr Ala Thr Cys Gln Arg Leu Pro Ala Asp Thr Gln Arg 
625                 630                 635                 640 


Pro Phe Ser Gly Lys Ile Glu Arg Tyr Ile Asp Lys Leu Gly Tyr Glu 
                645                 650                 655     


Leu Ala Lys Ile Lys Ala Lys Glu Leu Glu Gly Met Glu Ala Lys Glu 
            660                 665                 670         


Ile Lys Val Pro Ile Ile Leu Glu Gln Asn Ala Phe Glu Tyr Glu Glu 
        675                 680                 685             


Ser Leu Arg Lys Ser Lys Thr Gly Ser Asn Asp Arg Val Ile Asn Ser 
    690                 695                 700                 


Lys Lys Asp Arg Asp Gly Lys Lys Leu Ala Lys Ala Lys Glu Asn Ala 
705                 710                 715                 720 


Glu Asp Arg Leu Lys Asp Lys Asp Lys Arg Ile Lys Ala Phe Ser Ser 
                725                 730                 735     


Gly Ile Cys Pro Tyr Cys Gly Asp Thr Ile Gly Asp Asp Gly Glu Ile 
            740                 745                 750         


Asp His Ile Leu Pro Arg Ser His Thr Leu Lys Ile Tyr Gly Thr Val 
        755                 760                 765             


Phe Asn Pro Glu Gly Asn Leu Ile Tyr Val His Gln Lys Cys Asn Gln 
    770                 775                 780                 


Ala Lys Ala Asp Ser Ile Tyr Lys Leu Ser Asp Ile Lys Ala Gly Val 
785                 790                 795                 800 


Ser Ala Gln Trp Ile Glu Glu Gln Val Ala Asn Ile Lys Gly Tyr Lys 
                805                 810                 815     


Thr Phe Ser Val Leu Ser Ala Glu Gln Gln Lys Ala Phe Arg Tyr Ala 
            820                 825                 830         


Leu Phe Leu Gln Asn Asp Asn Glu Ala Tyr Lys Lys Val Val Asp Trp 
        835                 840                 845             


Leu Arg Thr Asp Gln Ser Ala Arg Val Asn Gly Thr Gln Lys Tyr Leu 
    850                 855                 860                 


Ala Lys Lys Ile Gln Glu Lys Leu Thr Lys Met Leu Pro Asn Lys His 
865                 870                 875                 880 


Leu Ser Phe Glu Phe Ile Leu Ala Asp Ala Thr Glu Val Ser Glu Leu 
                885                 890                 895     


Arg Arg Gln Tyr Ala Arg Gln Asn Pro Leu Leu Ala Lys Ala Glu Lys 
            900                 905                 910         


Gln Ala Pro Ser Ser His Ala Ile Asp Ala Val Met Ala Phe Val Ala 
        915                 920                 925             


Arg Tyr Gln Lys Val Phe Lys Asp Gly Thr Pro Pro Asn Ala Asp Glu 
    930                 935                 940                 


Val Ala Lys Leu Ala Met Leu Asp Ser Trp Asn Pro Ala Ser Asn Glu 
945                 950                 955                 960 


Pro Leu Thr Lys Gly Leu Ser Thr Asn Gln Lys Ile Glu Lys Met Ile 
                965                 970                 975     


Lys Ser Gly Asp Tyr Gly Gln Lys Asn Met Arg Glu Val Phe Gly Lys 
            980                 985                 990         


Ser Ile Phe Gly Glu Asn Ala Ile  Gly Glu Arg Tyr Lys  Pro Ile Val 
        995                 1000                 1005             


Val Gln  Glu Gly Gly Tyr Tyr  Ile Gly Tyr Pro Ala  Thr Val Lys 
    1010                 1015                 1020             


Lys Gly  Tyr Glu Leu Lys Asn  Cys Lys Val Val Thr  Ser Lys Asn 
    1025                 1030                 1035             


Asp Ile  Ala Lys Leu Glu Lys  Ile Ile Lys Asn Gln  Asp Leu Ile 
    1040                 1045                 1050             


Ser Leu  Lys Glu Asn Gln Tyr  Ile Lys Ile Phe Ser  Ile Asn Lys 
    1055                 1060                 1065             


Gln Thr  Ile Ser Glu Leu Ser  Asn Arg Tyr Phe Asn  Met Asn Tyr 
    1070                 1075                 1080             


Lys Asn  Leu Val Glu Arg Asp  Lys Glu Ile Val Gly  Leu Leu Glu 
    1085                 1090                 1095             


Phe Ile  Val Glu Asn Cys Arg  Tyr Tyr Thr Lys Lys  Val Asp Val 
    1100                 1105                 1110             


Lys Phe  Ala Pro Lys Tyr Ile  His Glu Thr Lys Tyr  Pro Phe Tyr 
    1115                 1120                 1125             


Asp Asp  Trp Arg Arg Phe Asp  Glu Ala Trp Arg Tyr  Leu Gln Glu 
    1130                 1135                 1140             


Asn Gln  Asn Lys Thr Ser Ser  Lys Asp Arg Phe Val  Ile Asp Lys 
    1145                 1150                 1155             


Ser Ser  Leu Asn Glu Tyr Tyr  Gln Pro Asp Lys Asn  Glu Tyr Lys 
    1160                 1165                 1170             


Leu Asp  Val Asp Thr Gln Pro  Ile Trp Asp Asp Phe  Cys Arg Trp 
    1175                 1180                 1185             


Tyr Phe  Leu Asp Arg Tyr Lys  Thr Ala Asn Asp Lys  Lys Ser Ile 
    1190                 1195                 1200             


Arg Ile  Lys Ala Arg Lys Thr  Phe Ser Leu Leu Ala  Glu Ser Gly 
    1205                 1210                 1215             


Val Gln  Gly Lys Val Phe Arg  Ala Lys Arg Lys Ile  Pro Thr Gly 
    1220                 1225                 1230             


Tyr Ala  Tyr Gln Ala Leu Pro  Met Asp Asn Asn Val  Ile Ala Gly 
    1235                 1240                 1245             


Asp Tyr  Ala Asn Ile Leu Leu  Glu Ala Asn Ser Lys  Thr Leu Ser 
    1250                 1255                 1260             


Leu Val  Pro Lys Ser Gly Ile  Ser Ile Glu Lys Gln  Leu Asp Lys 
    1265                 1270                 1275             


Lys Leu  Asp Val Ile Lys Lys  Thr Asp Val Arg Gly  Leu Ala Ile 
    1280                 1285                 1290             


Asp Asn  Asn Ser Phe Phe Asn  Ala Asp Phe Asp Thr  His Gly Ile 
    1295                 1300                 1305             


Arg Leu  Ile Val Glu Asn Thr  Ser Val Lys Val Gly  Asn Phe Pro 
    1310                 1315                 1320             


Ile Ser  Ala Ile Asp Lys Ser  Ala Lys Arg Met Ile  Phe Arg Ala 
    1325                 1330                 1335             


Leu Phe  Glu Lys Glu Lys Gly  Lys Arg Lys Lys Lys  Thr Thr Ile 
    1340                 1345                 1350             


Ser Phe  Lys Glu Ser Gly Pro  Val Gln Asp Tyr Leu  Lys Val Phe 
    1355                 1360                 1365             


Leu Lys  Lys Ile Val Lys Ile  Gln Leu Arg Thr Asp  Gly Ser Ile 
    1370                 1375                 1380             


Ser Asn  Ile Val Val Arg Lys  Asn Ala Ala Asp Phe  Thr Leu Ser 
    1385                 1390                 1395             


Phe Arg  Ser Glu His Ile Gln  Lys Leu Leu Lys 
    1400                 1405                 


<210> 619
<211> 1059
<212> PRT
<213> Wolinella succinogenes

<400> 619
Met Ile Glu Arg Ile Leu Gly Val Asp Leu Gly Ile Ser Ser Leu Gly 
1               5                   10                  15      


Trp Ala Ile Val Glu Tyr Asp Lys Asp Asp Glu Ala Ala Asn Arg Ile 
            20                  25                  30          


Ile Asp Cys Gly Val Arg Leu Phe Thr Ala Ala Glu Thr Pro Lys Lys 
        35                  40                  45              


Lys Glu Ser Pro Asn Lys Ala Arg Arg Glu Ala Arg Gly Ile Arg Arg 
    50                  55                  60                  


Val Leu Asn Arg Arg Arg Val Arg Met Asn Met Ile Lys Lys Leu Phe 
65                  70                  75                  80  


Leu Arg Ala Gly Leu Ile Gln Asp Val Asp Leu Asp Gly Glu Gly Gly 
                85                  90                  95      


Met Phe Tyr Ser Lys Ala Asn Arg Ala Asp Val Trp Glu Leu Arg His 
            100                 105                 110         


Asp Gly Leu Tyr Arg Leu Leu Lys Gly Asp Glu Leu Ala Arg Val Leu 
        115                 120                 125             


Ile His Ile Ala Lys His Arg Gly Tyr Lys Phe Ile Gly Asp Asp Glu 
    130                 135                 140                 


Ala Asp Glu Glu Ser Gly Lys Val Lys Lys Ala Gly Val Val Leu Arg 
145                 150                 155                 160 


Gln Asn Phe Glu Ala Ala Gly Cys Arg Thr Val Gly Glu Trp Leu Trp 
                165                 170                 175     


Arg Glu Arg Gly Ala Asn Gly Lys Lys Arg Asn Lys His Gly Asp Tyr 
            180                 185                 190         


Glu Ile Ser Ile His Arg Asp Leu Leu Val Glu Glu Val Glu Ala Ile 
        195                 200                 205             


Phe Val Ala Gln Gln Glu Met Arg Ser Thr Ile Ala Thr Asp Ala Leu 
    210                 215                 220                 


Lys Ala Ala Tyr Arg Glu Ile Ala Phe Phe Val Arg Pro Met Gln Arg 
225                 230                 235                 240 


Ile Glu Lys Met Val Gly His Cys Thr Tyr Phe Pro Glu Glu Arg Arg 
                245                 250                 255     


Ala Pro Lys Ser Ala Pro Thr Ala Glu Lys Phe Ile Ala Ile Ser Lys 
            260                 265                 270         


Phe Phe Ser Thr Val Ile Ile Asp Asn Glu Gly Trp Glu Gln Lys Ile 
        275                 280                 285             


Ile Glu Arg Lys Thr Leu Glu Glu Leu Leu Asp Phe Ala Val Ser Arg 
    290                 295                 300                 


Glu Lys Val Glu Phe Arg His Leu Arg Lys Phe Leu Asp Leu Ser Asp 
305                 310                 315                 320 


Asn Glu Ile Phe Lys Gly Leu His Tyr Lys Gly Lys Pro Lys Thr Ala 
                325                 330                 335     


Lys Lys Arg Glu Ala Thr Leu Phe Asp Pro Asn Glu Pro Thr Glu Leu 
            340                 345                 350         


Glu Phe Asp Lys Val Glu Ala Glu Lys Lys Ala Trp Ile Ser Leu Arg 
        355                 360                 365             


Gly Ala Ala Lys Leu Arg Glu Ala Leu Gly Asn Glu Phe Tyr Gly Arg 
    370                 375                 380                 


Phe Val Ala Leu Gly Lys His Ala Asp Glu Ala Thr Lys Ile Leu Thr 
385                 390                 395                 400 


Tyr Tyr Lys Asp Glu Gly Gln Lys Arg Arg Glu Leu Thr Lys Leu Pro 
                405                 410                 415     


Leu Glu Ala Glu Met Val Glu Arg Leu Val Lys Ile Gly Phe Ser Asp 
            420                 425                 430         


Phe Leu Lys Leu Ser Leu Lys Ala Ile Arg Asp Ile Leu Pro Ala Met 
        435                 440                 445             


Glu Ser Gly Ala Arg Tyr Asp Glu Ala Val Leu Met Leu Gly Val Pro 
    450                 455                 460                 


His Lys Glu Lys Ser Ala Ile Leu Pro Pro Leu Asn Lys Thr Asp Ile 
465                 470                 475                 480 


Asp Ile Leu Asn Pro Thr Val Ile Arg Ala Phe Ala Gln Phe Arg Lys 
                485                 490                 495     


Val Ala Asn Ala Leu Val Arg Lys Tyr Gly Ala Phe Asp Arg Val His 
            500                 505                 510         


Phe Glu Leu Ala Arg Glu Ile Asn Thr Lys Gly Glu Ile Glu Asp Ile 
        515                 520                 525             


Lys Glu Ser Gln Arg Lys Asn Glu Lys Glu Arg Lys Glu Ala Ala Asp 
    530                 535                 540                 


Trp Ile Ala Glu Thr Ser Phe Gln Val Pro Leu Thr Arg Lys Asn Ile 
545                 550                 555                 560 


Leu Lys Lys Arg Leu Tyr Ile Gln Gln Asp Gly Arg Cys Ala Tyr Thr 
                565                 570                 575     


Gly Asp Val Ile Glu Leu Glu Arg Leu Phe Asp Glu Gly Tyr Cys Glu 
            580                 585                 590         


Ile Asp His Ile Leu Pro Arg Ser Arg Ser Ala Asp Asp Ser Phe Ala 
        595                 600                 605             


Asn Lys Val Leu Cys Leu Ala Arg Ala Asn Gln Gln Lys Thr Asp Arg 
    610                 615                 620                 


Thr Pro Tyr Glu Trp Phe Gly His Asp Ala Ala Arg Trp Asn Ala Phe 
625                 630                 635                 640 


Glu Thr Arg Thr Ser Ala Pro Ser Asn Arg Val Arg Thr Gly Lys Gly 
                645                 650                 655     


Lys Ile Asp Arg Leu Leu Lys Lys Asn Phe Asp Glu Asn Ser Glu Met 
            660                 665                 670         


Ala Phe Lys Asp Arg Asn Leu Asn Asp Thr Arg Tyr Met Ala Arg Ala 
        675                 680                 685             


Ile Lys Thr Tyr Cys Glu Gln Tyr Trp Val Phe Lys Asn Ser His Thr 
    690                 695                 700                 


Lys Ala Pro Val Gln Val Arg Ser Gly Lys Leu Thr Ser Val Leu Arg 
705                 710                 715                 720 


Tyr Gln Trp Gly Leu Glu Ser Lys Asp Arg Glu Ser His Thr His His 
                725                 730                 735     


Ala Val Asp Ala Ile Ile Ile Ala Phe Ser Thr Gln Gly Met Val Gln 
            740                 745                 750         


Lys Leu Ser Glu Tyr Tyr Arg Phe Lys Glu Thr His Arg Glu Lys Glu 
        755                 760                 765             


Arg Pro Lys Leu Ala Val Pro Leu Ala Asn Phe Arg Asp Ala Val Glu 
    770                 775                 780                 


Glu Ala Thr Arg Ile Glu Asn Thr Glu Thr Val Lys Glu Gly Val Glu 
785                 790                 795                 800 


Val Lys Arg Leu Leu Ile Ser Arg Pro Pro Arg Ala Arg Val Thr Gly 
                805                 810                 815     


Gln Ala His Glu Gln Thr Ala Lys Pro Tyr Pro Arg Ile Lys Gln Val 
            820                 825                 830         


Lys Asn Lys Lys Lys Trp Arg Leu Ala Pro Ile Asp Glu Glu Lys Phe 
        835                 840                 845             


Glu Ser Phe Lys Ala Asp Arg Val Ala Ser Ala Asn Gln Lys Asn Phe 
    850                 855                 860                 


Tyr Glu Thr Ser Thr Ile Pro Arg Val Asp Val Tyr His Lys Lys Gly 
865                 870                 875                 880 


Lys Phe His Leu Val Pro Ile Tyr Leu His Glu Met Val Leu Asn Glu 
                885                 890                 895     


Leu Pro Asn Leu Ser Leu Gly Thr Asn Pro Glu Ala Met Asp Glu Asn 
            900                 905                 910         


Phe Phe Lys Phe Ser Ile Phe Lys Asp Asp Leu Ile Ser Ile Gln Thr 
        915                 920                 925             


Gln Gly Thr Pro Lys Lys Pro Ala Lys Ile Ile Met Gly Tyr Phe Lys 
    930                 935                 940                 


Asn Met His Gly Ala Asn Met Val Leu Ser Ser Ile Asn Asn Ser Pro 
945                 950                 955                 960 


Cys Glu Gly Phe Thr Cys Thr Pro Val Ser Met Asp Lys Lys His Lys 
                965                 970                 975     


Asp Lys Cys Lys Leu Cys Pro Glu Glu Asn Arg Ile Ala Gly Arg Cys 
            980                 985                 990         


Leu Gln Gly Phe Leu Asp Tyr Trp  Ser Gln Glu Gly Leu  Arg Pro Pro 
        995                 1000                 1005             


Arg Lys  Glu Phe Glu Cys Asp  Gln Gly Val Lys Phe  Ala Leu Asp 
    1010                 1015                 1020             


Val Lys  Lys Tyr Gln Ile Asp  Pro Leu Gly Tyr Tyr  Tyr Glu Val 
    1025                 1030                 1035             


Lys Gln  Glu Lys Arg Leu Gly  Thr Ile Pro Gln Met  Arg Ser Ala 
    1040                 1045                 1050             


Lys Lys  Leu Val Lys Lys 
    1055                 


<210> 620
<211> 1388
<212> PRT
<213> Zunongwangia profunda

<400> 620
Met Lys Arg Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Ala Leu Val Asn Glu Ala Glu Asn Glu Lys Glu Ile Ser Lys Ile Ile 
            20                  25                  30          


Lys Leu Gly Val Arg Val Asn Pro Leu Thr Ile Asp Glu Lys Thr Asn 
        35                  40                  45              


Phe Glu Lys Gly Arg Pro Leu Ser Thr Asn Ala Asp Arg Thr Leu Lys 
    50                  55                  60                  


Arg Gly Ala Arg Arg Asn Leu Gln Arg Tyr Lys Leu Arg Arg Glu Asn 
65                  70                  75                  80  


Leu Ile Glu Ile Leu Ile Asp Asn His Ile Ile Thr Lys Glu Thr Pro 
                85                  90                  95      


Leu Thr Glu Ile Gly Lys Gly Thr Thr Tyr Gln Thr Leu Ser Leu Arg 
            100                 105                 110         


Ala Lys Ala Val Arg Glu Arg Ile Asp Leu Glu Asp Phe Ala Lys Val 
        115                 120                 125             


Leu Leu Ala Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala 
    130                 135                 140                 


Ser Asn Asp Glu Glu Gly Gln Ala Ile Asp Gly Met Ala Ile Ala Lys 
145                 150                 155                 160 


Glu Leu Tyr Glu Arg Gly Ile Thr Pro Gly Gln Tyr Val Leu Glu Leu 
                165                 170                 175     


Leu Glu Asn Asp Arg Lys Tyr Ile Pro Asp Phe Tyr Arg Ser Asp Leu 
            180                 185                 190         


Lys Gln Glu Phe Asn Lys Ile Trp Asn Asn Gln Lys Thr Phe Tyr Pro 
        195                 200                 205             


Glu Ile Leu Thr Asp Glu Leu Phe Lys Glu Leu Asp Gly Lys Asn Lys 
    210                 215                 220                 


Ser Gln Thr Trp Ala Ile Cys Gln Lys Pro Phe Asn Ile Lys Gly Ile 
225                 230                 235                 240 


Lys Arg Ile Thr Lys Gly Arg Glu Lys Thr Ile Glu Asn Tyr His Trp 
                245                 250                 255     


Arg Val Lys Gly Leu Ser Gly Lys Leu Asn Leu Glu Lys Leu Ala Ile 
            260                 265                 270         


Ile Leu Gln Glu Ile Asn Asn Asp Ile Asn Gln Ser Ser Gly Tyr Leu 
        275                 280                 285             


Gly Gly Ile Ser Asp Lys Ser Lys Lys Leu Tyr Leu Asn Lys Glu Thr 
    290                 295                 300                 


Val Gly Glu Phe Leu Tyr Lys Gln Ile Ala Lys Asn Pro His Thr Ser 
305                 310                 315                 320 


Leu Lys Asn Gln Val Phe Tyr Arg His Asp Tyr Leu Asp Glu Phe Glu 
                325                 330                 335     


Gln Ile Trp Lys Thr Gln Ser Asn Phe Asn Ala Asn Leu Thr Asp Glu 
            340                 345                 350         


Leu Lys Gln Glu Ile Arg Asp Val Ile Ile Phe Tyr Gln Arg Lys Ile 
        355                 360                 365             


Lys Ser Gln Lys Ser Leu Ile Ser Phe Cys Gln Phe Glu Ser Trp Glu 
    370                 375                 380                 


Gln Glu Tyr Phe Asp Lys Glu Thr Gly Lys Thr Lys Thr Arg Thr Val 
385                 390                 395                 400 


Gly Arg Arg Val Ile Pro Lys Ser Ser Pro Leu Phe Gln Glu Phe Lys 
                405                 410                 415     


Ile Trp Gln Asn Leu Asn His Leu Val Phe Thr Asn Ser Glu Thr Asp 
            420                 425                 430         


Glu Lys Ile Glu Ile Lys Glu Val Glu Gln Glu Ile Arg Lys Glu Leu 
        435                 440                 445             


Phe Glu Glu Leu Asn Leu Arg Gly Asp Leu Asn Pro Asn Asp Leu Leu 
    450                 455                 460                 


Lys Ile Leu Arg Ser Gln Phe Lys Ile Gly Lys Leu Ser Asn Trp Lys 
465                 470                 475                 480 


Cys Asn Phe Glu Lys Ile Glu Gly Asn Arg Thr Asn Ala Ala Leu Phe 
                485                 490                 495     


Asn Ile Tyr Gln Lys Ile Ser Asp Phe Glu Gly Tyr Gly Ile Asp Trp 
            500                 505                 510         


Asn Lys Ser Asn Ala Lys Lys Ile Arg Lys Glu Leu Lys Ala Thr Phe 
        515                 520                 525             


Pro Glu Ile Gly Ile Asp Ala Ser Ile Leu Glu Phe Asp Ala Tyr Lys 
    530                 535                 540                 


Lys Gln Leu Thr Asn Gln Ser Ser Tyr Glu Leu Trp His Leu Leu Tyr 
545                 550                 555                 560 


Ser Ala Glu Glu Asp Phe Lys Ile Ser Glu Gln Asp Lys Leu Ile Tyr 
                565                 570                 575     


Gly Asn Ser Ser Val Ser Leu Lys Lys Lys Leu His Leu Lys Phe Gly 
            580                 585                 590         


Phe Asn Pro Glu Tyr Ala Lys Met Leu Ala Asn Leu Ser Leu Met Ser 
        595                 600                 605             


Asp Tyr Gly Asn Leu Ser Ala Lys Ala Ile Lys Lys Ile Leu Pro Tyr 
    610                 615                 620                 


Leu Glu Asp Gly His Leu Tyr Ser Glu Ala Cys Arg Leu Ala Gly Tyr 
625                 630                 635                 640 


Asn His Ser Lys Ser Leu Thr Ala Glu Glu Leu Glu Lys Phe Glu Pro 
                645                 650                 655     


Lys Ala Lys Leu Asp Leu Leu Lys Lys Asn Ser Leu Arg Asn Pro Val 
            660                 665                 670         


Val Glu Lys Ile Leu Asn Gln Met Val Asn Val Val Asn Gln Val Ile 
        675                 680                 685             


Asp Thr Tyr Gly Lys Pro Asp Gly Val Arg Ile Glu Leu Ala Arg Glu 
    690                 695                 700                 


Leu Lys Lys Ser Ala Lys Glu Arg Ala Glu Met Thr Lys Gly Ile Ala 
705                 710                 715                 720 


Asp Gly Thr Arg Arg Asn Glu Glu Ile Lys Lys Ile Ile Thr Gln Lys 
                725                 730                 735     


Phe Gly Ile Pro Asn Pro Thr Lys Ser Asp Leu Val Arg Tyr Arg Leu 
            740                 745                 750         


Trp Gln Glu Leu Glu Ser Arg Gly Tyr Lys Asp Ile Phe Thr Asp Lys 
        755                 760                 765             


Tyr Ile Ser Pro Asp Lys Ile Phe Ser Ser Glu Ile Asp Ile Glu His 
    770                 775                 780                 


Ile Ile Pro Lys Ala Leu Leu Phe Asp Asp Ser Phe Ser Asn Lys Thr 
785                 790                 795                 800 


Leu Ser Phe Arg Asn Val Asn Leu Lys Lys Ala Asn Arg Thr Ala Leu 
                805                 810                 815     


Asp Phe Ile Thr Gln Asp Tyr Gln Ser Asn Val Glu Ala Tyr Lys Glu 
            820                 825                 830         


Arg Val Glu Thr Trp Asn Lys Asp Asn His Ile Ser Lys Gly Lys Arg 
        835                 840                 845             


Asn Lys Leu Leu Met Ser Leu Lys Asp Ile Pro Asp Gly Phe Ile Glu 
    850                 855                 860                 


Arg Asp Leu Arg Asn Ser Gln Tyr Ile Ala Arg Lys Ala Lys Arg Met 
865                 870                 875                 880 


Leu Tyr Glu Val Phe Pro Asn Glu Val Leu Ala Thr Ser Gly Ser Ile 
                885                 890                 895     


Thr Asp Lys Leu Arg Ser Asp Trp Asp Leu Ile Asn Val Met Lys Glu 
            900                 905                 910         


Leu Asn Leu Pro Lys Tyr Lys Ala Leu Gly Leu Thr Glu Tyr Glu Glu 
        915                 920                 925             


Arg Leu Asp Lys Gly Thr Glu Glu Leu Phe Lys His Glu Val Ile Lys 
    930                 935                 940                 


Asp Trp Thr Lys Arg Asn Asp His Arg His His Ala Met Asp Ala Leu 
945                 950                 955                 960 


Ala Val Ala Phe Thr Thr His Asn His Ile Gln Tyr Ile Asn Asn Leu 
                965                 970                 975     


Asn Ala Arg Lys Asp Ile Thr Gln Asp Asn His Pro Ile Ile Lys Asn 
            980                 985                 990         


Ile Glu Asn Leu Ile Thr Glu Val  Asn Ser Lys Gly Lys  Arg Val Phe 
        995                 1000                 1005             


Lys Ala  Pro Met Ser Ser Phe  Arg Glu Ser Ala Lys  Glu Gln Ile 
    1010                 1015                 1020             


Glu Ala  Ile Leu Val Ser Phe  Lys Asn Lys Asn Lys  Val Val Thr 
    1025                 1030                 1035             


Lys Asn  Ile Asn Gln Thr Lys  Lys Glu Gly Gly Phe  Asn Tyr Gln 
    1040                 1045                 1050             


Asn Ala  Lys Thr Pro Arg Gly  Gln Leu His Lys Glu  Thr Ile Tyr 
    1055                 1060                 1065             


Gly Lys  Ser Lys Gln Pro Leu  Glu Lys Pro Val Lys  Ile Asn Asn 
    1070                 1075                 1080             


Arg Phe  Cys Lys Lys Gln Val  Gly Leu Ile Ile Asn  Phe Lys Glu 
    1085                 1090                 1095             


Gln Glu  Ala Val Leu His His  Leu Lys Lys Tyr Asp  Asn Asn Glu 
    1100                 1105                 1110             


Lys Ile  Ala Phe Ser Asn Lys  Thr Leu Lys Ser Asp  Pro Ile Gln 
    1115                 1120                 1125             


Val Asn  Gly Ser Pro Leu Arg  Glu Val Lys Ile Phe  Glu Glu Ile 
    1130                 1135                 1140             


Phe Thr  Ile Arg Lys Asp Ile  Asn Pro Asp Asn Phe  Lys Thr Gln 
    1145                 1150                 1155             


Lys His  Leu Asp Lys Ile Ile  Asp Lys Gly Ile Lys  Glu Val Met 
    1160                 1165                 1170             


Lys Lys  Arg Leu Glu Glu Tyr  Asn Gly Asp Phe Lys  Thr Ala Phe 
    1175                 1180                 1185             


Ser Asp  Leu Asp Lys Asn Pro  Ile Trp Leu Asn Gln  Ser Lys Gly 
    1190                 1195                 1200             


Ile Thr  Ile Lys Arg Ala Thr  Ile Ser Gly Val Thr  Asn Ala Glu 
    1205                 1210                 1215             


Pro Leu  His Gln Ala Lys Asp  His Leu Gly Asn Ile  Ile Leu Asp 
    1220                 1225                 1230             


Asp Asn  Gly Lys Glu Ile Pro  Ile Asp Tyr Val Ser  Thr Gly Asn 
    1235                 1240                 1245             


Asn His  His Val Ala Ile Tyr  Gln Asp Glu Ser Gly  Asn Leu Gln 
    1250                 1255                 1260             


Glu Glu  Val Val Ser Phe Tyr  Glu Ala Val Ile Arg  Lys Asn Gln 
    1265                 1270                 1275             


Asp Gln  Pro Ile Ile Lys Lys  Arg His Pro Lys Gly  Trp Lys Phe 
    1280                 1285                 1290             


Leu Phe  Thr Met Lys Gln Asn  Glu Met Phe Val Phe  Ser Ser Glu 
    1295                 1300                 1305             


Asn Phe  Asn Pro Ser Glu Ile  Asp Leu Leu Asp Glu  Lys Asn Ala 
    1310                 1315                 1320             


Ala Ile  Ile Ser Pro Asn Leu  Phe Arg Val Gln Lys  Ile Ala Thr 
    1325                 1330                 1335             


Lys Asn  Tyr Met Phe Arg His  His Leu Glu Thr Glu  Val Thr Asn 
    1340                 1345                 1350             


Asn Leu  Asp Phe Thr Tyr Arg  His Phe Gln Ala Thr  Glu Trp Leu 
    1355                 1360                 1365             


Arg Asn  Leu Cys Lys Val Arg  Ile Asp His Ile Gly  Arg Ile Val 
    1370                 1375                 1380             


Gln Ile  Gly Glu Tyr 
    1385             


<210> 621

<400> 621
000


<210> 622

<400> 622
000


<210> 623

<400> 623
000


<210> 624

<400> 624
000


<210> 625

<400> 625
000


<210> 626

<400> 626
000


<210> 627

<400> 627
000


<210> 628

<400> 628
000


<210> 629

<400> 629
000


<210> 630

<400> 630
000


<210> 631

<400> 631
000


<210> 632
<211> 22
<212> RNA
<213> Homo sapiens

<400> 632
ugcucagguu gcacagcugg ga                                                22


<210> 633
<211> 22
<212> RNA
<213> Homo sapiens

<400> 633
ucccagcugu gcaaccugag ca                                                22


<210> 634
<211> 22
<212> RNA
<213> Homo sapiens

<400> 634
ucaggugugg aaacugaggc ag                                                22


<210> 635
<211> 22
<212> RNA
<213> Homo sapiens

<400> 635
cugccucagu uuccacaccu ga                                                22


<210> 636
<211> 22
<212> RNA
<213> Homo sapiens

<400> 636
caaaaccgcg auuacucuug ca                                                22


<210> 637
<211> 22
<212> RNA
<213> Homo sapiens

<400> 637
ugcaagagua aucgcgguuu ug                                                22


<210> 638
<211> 21
<212> RNA
<213> Homo sapiens

<400> 638
aaaaguaauu gugguuuuug c                                                 21


<210> 639
<211> 21
<212> RNA
<213> Homo sapiens

<400> 639
gcaaaaacca caauuacuuu u                                                 21


<210> 640
<211> 21
<212> RNA
<213> Homo sapiens

<400> 640
aaaaacugca aucacuuuug c                                                 21


<210> 641
<211> 21
<212> RNA
<213> Homo sapiens

<400> 641
gcaaaaguga uugcaguuuu u                                                 21


<210> 642
<211> 22
<212> RNA
<213> Homo sapiens

<400> 642
caaaagugau ugugguuuuu gc                                                22


<210> 643
<211> 22
<212> RNA
<213> Homo sapiens

<400> 643
gcaaaaacca caaucacuuu ug                                                22


<210> 644
<211> 22
<212> RNA
<213> Homo sapiens

<400> 644
agcaguguuu guuuugccca ca                                                22


<210> 645
<211> 22
<212> RNA
<213> Homo sapiens

<400> 645
ugugggcaaa acaaacacug cu                                                22


<210> 646
<211> 22
<212> RNA
<213> Homo sapiens

<400> 646
ucgggcgcaa gagcacugca gu                                                22


<210> 647
<211> 22
<212> RNA
<213> Homo sapiens

<400> 647
acugcagugc ucuugcgccc ga                                                22


<210> 648
<211> 21
<212> RNA
<213> Homo sapiens

<400> 648
acacuuguug ggaugaccug c                                                 21


<210> 649
<211> 21
<212> RNA
<213> Homo sapiens

<400> 649
gcaggucauc ccaacaagug u                                                 21


<210> 650
<211> 24
<212> RNA
<213> Homo sapiens

<400> 650
aggagcuauc cacuccaggu gucc                                              24


<210> 651
<211> 24
<212> RNA
<213> Homo sapiens

<400> 651
ggacaccugg aguggauagc uccu                                              24


<210> 652
<211> 23
<212> RNA
<213> Homo sapiens

<400> 652
ccagagcagc cugcgguaac agu                                               23


<210> 653
<211> 23
<212> RNA
<213> Homo sapiens

<400> 653
acuguuaccg caggcugcuc ugg                                               23


<210> 654
<211> 22
<212> RNA
<213> Homo sapiens

<400> 654
aguugccagg gcugccuuug gu                                                22


<210> 655
<211> 22
<212> RNA
<213> Homo sapiens

<400> 655
accaaaggca gcccuggcaa cu                                                22


<210> 656
<211> 21
<212> RNA
<213> Homo sapiens

<400> 656
uagaccaucu uucuagagua u                                                 21


<210> 657
<211> 21
<212> RNA
<213> Homo sapiens

<400> 657
auacucuaga aagauggucu a                                                 21


<210> 658
<211> 22
<212> RNA
<213> Homo sapiens

<400> 658
agcucuagaa agauuguuga cc                                                22


<210> 659
<211> 22
<212> RNA
<213> Homo sapiens

<400> 659
ggucaacaau cuuucuagag cu                                                22


<210> 660
<211> 21
<212> RNA
<213> Homo sapiens

<400> 660
gggacuagga ugcagaccuc c                                                 21


<210> 661
<211> 21
<212> RNA
<213> Homo sapiens

<400> 661
ggaggucugc auccuagucc c                                                 21


<210> 662
<211> 23
<212> RNA
<213> Homo sapiens

<400> 662
aggucugcau ucaaaucccc aga                                               23


<210> 663
<211> 23
<212> RNA
<213> Homo sapiens

<400> 663
ucuggggauu ugaaugcaga ccu                                               23


<210> 664
<211> 20
<212> RNA
<213> Homo sapiens

<400> 664
cauuacagca cagccauucu                                                   20


<210> 665
<211> 20
<212> RNA
<213> Homo sapiens

<400> 665
agaauggcug ugcuguaaug                                                   20


<210> 666
<211> 21
<212> RNA
<213> Homo sapiens

<400> 666
ucuggcugug cuguaaugca g                                                 21


<210> 667
<211> 21
<212> RNA
<213> Homo sapiens

<400> 667
cugcauuaca gcacagccag a                                                 21


<210> 668
<211> 21
<212> RNA
<213> Homo sapiens

<400> 668
ugacuucuac cucuuccaaa g                                                 21


<210> 669
<211> 21
<212> RNA
<213> Homo sapiens

<400> 669
cuuuggaaga gguagaaguc a                                                 21


<210> 670
<211> 22
<212> RNA
<213> Homo sapiens

<400> 670
uuggaauagg ggauaucuca gc                                                22


<210> 671
<211> 22
<212> RNA
<213> Homo sapiens

<400> 671
gcugagauau ccccuauucc aa                                                22


<210> 672
<211> 22
<212> RNA
<213> Homo sapiens

<400> 672
ucguaucaga gauuccagac ac                                                22


<210> 673
<211> 22
<212> RNA
<213> Homo sapiens

<400> 673
gugucuggaa ucucugauac ga                                                22


<210> 674
<211> 23
<212> RNA
<213> Homo sapiens

<400> 674
acugggaugu cacugaauau ggu                                               23


<210> 675
<211> 23
<212> RNA
<213> Homo sapiens

<400> 675
accauauuca gugacauccc agu                                               23


<210> 676
<211> 22
<212> RNA
<213> Homo sapiens

<400> 676
caaaguccuu ccuauuuuuc cc                                                22


<210> 677
<211> 22
<212> RNA
<213> Homo sapiens

<400> 677
gggaaaaaua ggaaggacuu ug                                                22


<210> 678
<211> 21
<212> RNA
<213> Homo sapiens

<400> 678
gaagaauagg agggacuuug u                                                 21


<210> 679
<211> 21
<212> RNA
<213> Homo sapiens

<400> 679
acaaaguccc uccuauucuu c                                                 21


<210> 680
<211> 22
<212> RNA
<213> Homo sapiens

<400> 680
ugggccaugc auuucuagaa cu                                                22


<210> 681
<211> 22
<212> RNA
<213> Homo sapiens

<400> 681
aguucuagaa augcauggcc ca                                                22


<210> 682
<211> 21
<212> RNA
<213> Homo sapiens

<400> 682
ucuagaaaug caugacccac c                                                 21


<210> 683
<211> 21
<212> RNA
<213> Homo sapiens

<400> 683
ggugggucau gcauuucuag a                                                 21


<210> 684
<211> 22
<212> RNA
<213> Homo sapiens

<400> 684
uuccacugcc acuaccuaau uu                                                22


<210> 685
<211> 22
<212> RNA
<213> Homo sapiens

<400> 685
aaauuaggua guggcagugg aa                                                22


<210> 686
<211> 21
<212> RNA
<213> Homo sapiens

<400> 686
auuagguagu ggcaguggaa c                                                 21


<210> 687
<211> 21
<212> RNA
<213> Homo sapiens

<400> 687
guuccacugc cacuaccuaa u                                                 21


<210> 688
<211> 21
<212> RNA
<213> Homo sapiens

<400> 688
caccgacucu gucuccugca g                                                 21


<210> 689
<211> 21
<212> RNA
<213> Homo sapiens

<400> 689
cugcaggaga cagagucggu g                                                 21


<210> 690
<211> 22
<212> RNA
<213> Homo sapiens

<400> 690
cagcagggga gagagaggag uc                                                22


<210> 691
<211> 22
<212> RNA
<213> Homo sapiens

<400> 691
gacuccucuc ucuccccugc ug                                                22


<210> 692
<211> 22
<212> RNA
<213> Homo sapiens

<400> 692
uuccagcccu ucuaauggua gg                                                22


<210> 693
<211> 22
<212> RNA
<213> Homo sapiens

<400> 693
ccuaccauua gaagggcugg aa                                                22


<210> 694
<211> 22
<212> RNA
<213> Homo sapiens

<400> 694
uaccauuaga agagcuggaa ga                                                22


<210> 695
<211> 22
<212> RNA
<213> Homo sapiens

<400> 695
ucuuccagcu cuucuaaugg ua                                                22


<210> 696
<211> 21
<212> RNA
<213> Homo sapiens

<400> 696
ucaaguguca ucugucccua g                                                 21


<210> 697
<211> 21
<212> RNA
<213> Homo sapiens

<400> 697
cuagggacag augacacuug a                                                 21


<210> 698
<211> 23
<212> RNA
<213> Homo sapiens

<400> 698
uuugggauug acgccacaug ucu                                               23


<210> 699
<211> 23
<212> RNA
<213> Homo sapiens

<400> 699
agacaugugg cgucaauccc aaa                                               23


<210> 700
<211> 21
<212> RNA
<213> Homo sapiens

<400> 700
cugccuguuc uuccacucca g                                                 21


<210> 701
<211> 21
<212> RNA
<213> Homo sapiens

<400> 701
cuggagugga agaacaggca g                                                 21


<210> 702
<211> 23
<212> RNA
<213> Homo sapiens

<400> 702
uauggagugg acuuucagcu ggc                                               23


<210> 703
<211> 23
<212> RNA
<213> Homo sapiens

<400> 703
gccagcugaa aguccacucc aua                                               23


<210> 704
<211> 22
<212> RNA
<213> Homo sapiens

<400> 704
ccucaccauc ccuucugccu gc                                                22


<210> 705
<211> 22
<212> RNA
<213> Homo sapiens

<400> 705
gcaggcagaa gggaugguga gg                                                22


<210> 706
<211> 23
<212> RNA
<213> Homo sapiens

<400> 706
caggcagaag uggggcugac agg                                               23


<210> 707
<211> 23
<212> RNA
<213> Homo sapiens

<400> 707
ccugucagcc ccacuucugc cug                                               23


<210> 708
<211> 20
<212> RNA
<213> Homo sapiens

<400> 708
ucucuucauc uaccccccag                                                   20


<210> 709
<211> 20
<212> RNA
<213> Homo sapiens

<400> 709
cuggggggua gaugaagaga                                                   20


<210> 710
<211> 21
<212> RNA
<213> Homo sapiens

<400> 710
uuggagggug uggaagacau c                                                 21


<210> 711
<211> 21
<212> RNA
<213> Homo sapiens

<400> 711
gaugucuucc acacccucca a                                                 21


<210> 712
<211> 22
<212> RNA
<213> Homo sapiens

<400> 712
cugccagccc cguuccaggg ca                                                22


<210> 713
<211> 22
<212> RNA
<213> Homo sapiens

<400> 713
ugcccuggaa cggggcuggc ag                                                22


<210> 714
<211> 23
<212> RNA
<213> Homo sapiens

<400> 714
acaaaguaca gcauuagccu uag                                               23


<210> 715
<211> 23
<212> RNA
<213> Homo sapiens

<400> 715
cuaaggcuaa ugcuguacuu ugu                                               23


<210> 716
<211> 23
<212> RNA
<213> Homo sapiens

<400> 716
aaaggucauu guaagguuaa ugc                                               23


<210> 717
<211> 23
<212> RNA
<213> Homo sapiens

<400> 717
gcauuaaccu uacaaugacc uuu                                               23


<210> 718
<211> 22
<212> RNA
<213> Homo sapiens

<400> 718
ugaggcuaau gcacuacuuc ac                                                22


<210> 719
<211> 22
<212> RNA
<213> Homo sapiens

<400> 719
gugaaguagu gcauuagccu ca                                                22


<210> 720
<211> 24
<212> RNA
<213> Homo sapiens

<400> 720
uauagagagc aggaagauua augu                                              24


<210> 721
<211> 24
<212> RNA
<213> Homo sapiens

<400> 721
acauuaaucu uccugcucuc uaua                                              24


<210> 722
<211> 23
<212> RNA
<213> Homo sapiens

<400> 722
gugcuucauc guaauuaacc uua                                               23


<210> 723
<211> 23
<212> RNA
<213> Homo sapiens

<400> 723
uaagguuaau uacgaugaag cac                                               23


<210> 724
<211> 24
<212> RNA
<213> Homo sapiens

<400> 724
guggaaagca ugcauccagg gugu                                              24


<210> 725
<211> 24
<212> RNA
<213> Homo sapiens

<400> 725
acacccugga ugcaugcuuu ccac                                              24


<210> 726
<211> 22
<212> RNA
<213> Homo sapiens

<400> 726
agacacauuu ggagagggaa cc                                                22


<210> 727
<211> 22
<212> RNA
<213> Homo sapiens

<400> 727
gguucccucu ccaaaugugu cu                                                22


<210> 728
<211> 22
<212> RNA
<213> Homo sapiens

<400> 728
uucccuuugu cauccuaugc cu                                                22


<210> 729
<211> 22
<212> RNA
<213> Homo sapiens

<400> 729
aggcauagga ugacaaaggg aa                                                22


<210> 730
<211> 21
<212> RNA
<213> Homo sapiens

<400> 730
gcugggaagg caaagggacg u                                                 21


<210> 731
<211> 21
<212> RNA
<213> Homo sapiens

<400> 731
acgucccuuu gccuucccag c                                                 21


<210> 732
<211> 21
<212> RNA
<213> Homo sapiens

<400> 732
uaccacaggg uagaaccacg g                                                 21


<210> 733
<211> 21
<212> RNA
<213> Homo sapiens

<400> 733
ccgugguucu acccuguggu a                                                 21


<210> 734
<211> 22
<212> RNA
<213> Homo sapiens

<400> 734
ggcuggagcg agugcagugg ug                                                22


<210> 735
<211> 22
<212> RNA
<213> Homo sapiens

<400> 735
caccacugca cucgcuccag cc                                                22


<210> 736
<211> 18
<212> RNA
<213> Homo sapiens

<400> 736
ccaggcucug caguggga                                                     18


<210> 737
<211> 18
<212> RNA
<213> Homo sapiens

<400> 737
ucccacugca gagccugg                                                     18


<210> 738
<211> 22
<212> RNA
<213> Homo sapiens

<400> 738
cugggaggug ugauauugug gu                                                22


<210> 739
<211> 22
<212> RNA
<213> Homo sapiens

<400> 739
accacaauau cacaccuccc ag                                                22


<210> 740
<211> 22
<212> RNA
<213> Homo sapiens

<400> 740
gggaggugug aucucacacu cg                                                22


<210> 741
<211> 22
<212> RNA
<213> Homo sapiens

<400> 741
cgagugugag aucacaccuc cc                                                22


<210> 742
<211> 22
<212> RNA
<213> Homo sapiens

<400> 742
ugugauauca ugguuccugg ga                                                22


<210> 743
<211> 22
<212> RNA
<213> Homo sapiens

<400> 743
ucccaggaac caugauauca ca                                                22


<210> 744
<211> 22
<212> RNA
<213> Homo sapiens

<400> 744
ugugauaucg ugcuuccugg ga                                                22


<210> 745
<211> 22
<212> RNA
<213> Homo sapiens

<400> 745
ucccaggaag cacgauauca ca                                                22


<210> 746
<211> 18
<212> RNA
<213> Homo sapiens

<400> 746
ggugggcuuc ccggaggg                                                     18


<210> 747
<211> 18
<212> RNA
<213> Homo sapiens

<400> 747
cccuccggga agcccacc                                                     18


<210> 748
<211> 18
<212> RNA
<213> Homo sapiens

<400> 748
cacugcagga cucagcag                                                     18


<210> 749
<211> 18
<212> RNA
<213> Homo sapiens

<400> 749
cugcugaguc cugcagug                                                     18


<210> 750
<211> 17
<212> RNA
<213> Homo sapiens

<400> 750
ugagggagga gacugca                                                      17


<210> 751
<211> 17
<212> RNA
<213> Homo sapiens

<400> 751
ugcagucucc ucccuca                                                      17


<210> 752
<211> 18
<212> RNA
<213> Homo sapiens

<400> 752
gaggcugaag gaagaugg                                                     18


<210> 753
<211> 18
<212> RNA
<213> Homo sapiens

<400> 753
ccaucuuccu ucagccuc                                                     18


<210> 754
<211> 22
<212> RNA
<213> Homo sapiens

<400> 754
gucacugaug ucuguagcug ag                                                22


<210> 755
<211> 22
<212> RNA
<213> Homo sapiens

<400> 755
cucagcuaca gacaucagug ac                                                22


<210> 756
<211> 22
<212> RNA
<213> Homo sapiens

<400> 756
accugucugu ggaaaggagc ua                                                22


<210> 757
<211> 22
<212> RNA
<213> Homo sapiens

<400> 757
uagcuccuuu ccacagacag gu                                                22


<210> 758
<211> 22
<212> RNA
<213> Homo sapiens

<400> 758
agaguuaacu caaaauggac ua                                                22


<210> 759
<211> 22
<212> RNA
<213> Homo sapiens

<400> 759
uaguccauuu ugaguuaacu cu                                                22


<210> 760
<211> 22
<212> RNA
<213> Homo sapiens

<400> 760
uguugggauu cagcaggacc au                                                22


<210> 761
<211> 22
<212> RNA
<213> Homo sapiens

<400> 761
augguccugc ugaaucccaa ca                                                22


<210> 762
<211> 17
<212> RNA
<213> Homo sapiens

<400> 762
gaagauggac guacuuu                                                      17


<210> 763
<211> 17
<212> RNA
<213> Homo sapiens

<400> 763
aaaguacguc caucuuc                                                      17


<210> 764
<211> 21
<212> RNA
<213> Homo sapiens

<400> 764
ucugaauaga gucugaagag u                                                 21


<210> 765
<211> 21
<212> RNA
<213> Homo sapiens

<400> 765
acucuucaga cucuauucag a                                                 21


<210> 766
<211> 22
<212> RNA
<213> Homo sapiens

<400> 766
caaggagacg ggaacaugga gc                                                22


<210> 767
<211> 22
<212> RNA
<213> Homo sapiens

<400> 767
gcuccauguu cccgucuccu ug                                                22


<210> 768
<211> 20
<212> RNA
<213> Homo sapiens

<400> 768
aaaagcuggg cugagaggcg                                                   20


<210> 769
<211> 20
<212> RNA
<213> Homo sapiens

<400> 769
cgccucucag cccagcuuuu                                                   20


<210> 770
<211> 18
<212> RNA
<213> Homo sapiens

<400> 770
aggcuggagu gagcggag                                                     18


<210> 771
<211> 18
<212> RNA
<213> Homo sapiens

<400> 771
cuccgcucac uccagccu                                                     18


<210> 772
<211> 22
<212> RNA
<213> Homo sapiens

<400> 772
gcgacucuga aaacuagaag gu                                                22


<210> 773
<211> 22
<212> RNA
<213> Homo sapiens

<400> 773
accuucuagu uuucagaguc gc                                                22


<210> 774
<211> 20
<212> RNA
<213> Homo sapiens

<400> 774
aaagacucug caagaugccu                                                   20


<210> 775
<211> 20
<212> RNA
<213> Homo sapiens

<400> 775
aggcaucuug cagagucuuu                                                   20


<210> 776
<211> 21
<212> RNA
<213> Homo sapiens

<400> 776
acaggagugg gggugggaca u                                                 21


<210> 777
<211> 21
<212> RNA
<213> Homo sapiens

<400> 777
augucccacc cccacuccug u                                                 21


<210> 778
<211> 21
<212> RNA
<213> Homo sapiens

<400> 778
cgucccaccc cccacuccug u                                                 21


<210> 779
<211> 21
<212> RNA
<213> Homo sapiens

<400> 779
acaggagugg ggggugggac g                                                 21


<210> 780
<211> 18
<212> RNA
<213> Homo sapiens

<400> 780
aggagaagua aaguagaa                                                     18


<210> 781
<211> 18
<212> RNA
<213> Homo sapiens

<400> 781
uucuacuuua cuucuccu                                                     18


<210> 782
<211> 22
<212> RNA
<213> Homo sapiens

<400> 782
auggccagag cucacacaga gg                                                22


<210> 783
<211> 22
<212> RNA
<213> Homo sapiens

<400> 783
ccucugugug agcucuggcc au                                                22


<210> 784
<211> 21
<212> RNA
<213> Homo sapiens

<400> 784
ugggcucagg guacaaaggu u                                                 21


<210> 785
<211> 21
<212> RNA
<213> Homo sapiens

<400> 785
aaccuuugua cccugagccc a                                                 21


<210> 786
<211> 21
<212> RNA
<213> Homo sapiens

<400> 786
cacaggcuua gaaaagacag u                                                 21


<210> 787
<211> 21
<212> RNA
<213> Homo sapiens

<400> 787
acugucuuuu cuaagccugu g                                                 21


<210> 788
<211> 22
<212> RNA
<213> Homo sapiens

<400> 788
gugacugaua ccuuggaggc au                                                22


<210> 789
<211> 22
<212> RNA
<213> Homo sapiens

<400> 789
augccuccaa gguaucaguc ac                                                22


<210> 790
<211> 22
<212> RNA
<213> Homo sapiens

<400> 790
ugucgugggg cuugcuggcu ug                                                22


<210> 791
<211> 22
<212> RNA
<213> Homo sapiens

<400> 791
caagccagca agccccacga ca                                                22


<210> 792
<211> 17
<212> RNA
<213> Homo sapiens

<400> 792
acagggagga gauugua                                                      17


<210> 793
<211> 17
<212> RNA
<213> Homo sapiens

<400> 793
uacaaucucc ucccugu                                                      17


<210> 794
<211> 17
<212> RNA
<213> Homo sapiens

<400> 794
gccggacaag agggagg                                                      17


<210> 795
<211> 17
<212> RNA
<213> Homo sapiens

<400> 795
ccucccucuu guccggc                                                      17


<210> 796
<211> 17
<212> RNA
<213> Homo sapiens

<400> 796
uuggaggcgu ggguuuu                                                      17


<210> 797
<211> 17
<212> RNA
<213> Homo sapiens

<400> 797
aaaacccacg ccuccaa                                                      17


<210> 798
<211> 18
<212> RNA
<213> Homo sapiens

<400> 798
cucgaguugg aagaggcg                                                     18


<210> 799
<211> 18
<212> RNA
<213> Homo sapiens

<400> 799
cgccucuucc aacucgag                                                     18


<210> 800
<211> 21
<212> RNA
<213> Homo sapiens

<400> 800
cacggcaaaa gaaacaaucc a                                                 21


<210> 801
<211> 21
<212> RNA
<213> Homo sapiens

<400> 801
uggauuguuu cuuuugccgu g                                                 21


<210> 802
<211> 22
<212> RNA
<213> Homo sapiens

<400> 802
agauuguuuc uuuugccgug ca                                                22


<210> 803
<211> 22
<212> RNA
<213> Homo sapiens

<400> 803
ugcacggcaa aagaaacaau cu                                                22


<210> 804
<211> 17
<212> RNA
<213> Homo sapiens

<400> 804
ggugggggcu guuguuu                                                      17


<210> 805
<211> 17
<212> RNA
<213> Homo sapiens

<400> 805
aaacaacagc ccccacc                                                      17


<210> 806
<211> 20
<212> RNA
<213> Homo sapiens

<400> 806
ggcuccuugg ucuaggggua                                                   20


<210> 807
<211> 20
<212> RNA
<213> Homo sapiens

<400> 807
uaccccuaga ccaaggagcc                                                   20


<210> 808
<211> 22
<212> RNA
<213> Homo sapiens

<400> 808
cgucccgggg cugcgcgagg ca                                                22


<210> 809
<211> 22
<212> RNA
<213> Homo sapiens

<400> 809
ugccucgcgc agccccggga cg                                                22


<210> 810
<211> 22
<212> RNA
<213> Homo sapiens

<400> 810
uggggauuug gagaaguggu ga                                                22


<210> 811
<211> 22
<212> RNA
<213> Homo sapiens

<400> 811
ucaccacuuc uccaaauccc ca                                                22


<210> 812
<211> 17
<212> RNA
<213> Homo sapiens

<400> 812
ugguagagcu gaggaca                                                      17


<210> 813
<211> 17
<212> RNA
<213> Homo sapiens

<400> 813
uguccucagc ucuacca                                                      17


<210> 814
<211> 23
<212> RNA
<213> Homo sapiens

<400> 814
uugaauucuu ggccuuaagu gau                                               23


<210> 815
<211> 23
<212> RNA
<213> Homo sapiens

<400> 815
aucacuuaag gccaagaauu caa                                               23


<210> 816
<211> 20
<212> RNA
<213> Homo sapiens

<400> 816
gagcuugguc uguagcgguu                                                   20


<210> 817
<211> 20
<212> RNA
<213> Homo sapiens

<400> 817
aaccgcuaca gaccaagcuc                                                   20


<210> 818
<211> 20
<212> RNA
<213> Homo sapiens

<400> 818
ggauccgagu cacggcacca                                                   20


<210> 819
<211> 20
<212> RNA
<213> Homo sapiens

<400> 819
uggugccgug acucggaucc                                                   20


<210> 820
<211> 17
<212> RNA
<213> Homo sapiens

<400> 820
agggugugug uguuuuu                                                      17


<210> 821
<211> 17
<212> RNA
<213> Homo sapiens

<400> 821
aaaaacacac acacccu                                                      17


<210> 822
<211> 17
<212> RNA
<213> Homo sapiens

<400> 822
ccugguggcu uccuuuu                                                      17


<210> 823
<211> 17
<212> RNA
<213> Homo sapiens

<400> 823
aaaaggaagc caccagg                                                      17


<210> 824
<211> 22
<212> RNA
<213> Homo sapiens

<400> 824
ucacaaggua uugacuggcg ua                                                22


<210> 825
<211> 22
<212> RNA
<213> Homo sapiens

<400> 825
uacgccaguc aauaccuugu ga                                                22


<210> 826
<211> 19
<212> RNA
<213> Homo sapiens

<400> 826
agagguaggu guggaagaa                                                    19


<210> 827
<211> 19
<212> RNA
<213> Homo sapiens

<400> 827
uucuuccaca ccuaccucu                                                    19


<210> 828
<211> 22
<212> RNA
<213> Homo sapiens

<400> 828
ccaggaggcg gaggaggugg ag                                                22


<210> 829
<211> 22
<212> RNA
<213> Homo sapiens

<400> 829
cuccaccucc uccgccuccu gg                                                22


<210> 830
<211> 22
<212> RNA
<213> Homo sapiens

<400> 830
auagugguug ugaauuuacc uu                                                22


<210> 831
<211> 22
<212> RNA
<213> Homo sapiens

<400> 831
aagguaaauu cacaaccacu au                                                22


<210> 832
<211> 23
<212> RNA
<213> Homo sapiens

<400> 832
gauugagacu aguagggcua ggc                                               23


<210> 833
<211> 23
<212> RNA
<213> Homo sapiens

<400> 833
gccuagcccu acuagucuca auc                                               23


<210> 834
<211> 23
<212> RNA
<213> Homo sapiens

<400> 834
ugacacggag gguggcuugg gaa                                               23


<210> 835
<211> 23
<212> RNA
<213> Homo sapiens

<400> 835
uucccaagcc acccuccgug uca                                               23


<210> 836
<211> 17
<212> RNA
<213> Homo sapiens

<400> 836
gagacugggg uggggcc                                                      17


<210> 837
<211> 17
<212> RNA
<213> Homo sapiens

<400> 837
ggccccaccc cagucuc                                                      17


<210> 838
<211> 21
<212> RNA
<213> Homo sapiens

<400> 838
aagguuugga uagaugcaau a                                                 21


<210> 839
<211> 21
<212> RNA
<213> Homo sapiens

<400> 839
uauugcaucu auccaaaccu u                                                 21


<210> 840
<211> 22
<212> RNA
<213> Homo sapiens

<400> 840
cucaaguagu cugaccaggg ga                                                22


<210> 841
<211> 22
<212> RNA
<213> Homo sapiens

<400> 841
uccccugguc agacuacuug ag                                                22


<210> 842
<211> 18
<212> RNA
<213> Homo sapiens

<400> 842
gggugcgggc cggcgggg                                                     18


<210> 843
<211> 18
<212> RNA
<213> Homo sapiens

<400> 843
ccccgccggc ccgcaccc                                                     18


<210> 844
<211> 18
<212> RNA
<213> Homo sapiens

<400> 844
agagcagaag gaugagau                                                     18


<210> 845
<211> 18
<212> RNA
<213> Homo sapiens

<400> 845
aucucauccu ucugcucu                                                     18


<210> 846
<211> 21
<212> RNA
<213> Homo sapiens

<400> 846
uggcaaacgu ggaagccgag a                                                 21


<210> 847
<211> 21
<212> RNA
<213> Homo sapiens

<400> 847
ucucggcuuc cacguuugcc a                                                 21


<210> 848
<211> 18
<212> RNA
<213> Homo sapiens

<400> 848
gguggggggu guuguuuu                                                     18


<210> 849
<211> 18
<212> RNA
<213> Homo sapiens

<400> 849
aaaacaacac cccccacc                                                     18


<210> 850
<211> 22
<212> RNA
<213> Homo sapiens

<400> 850
cuagugcucu ccguuacaag ua                                                22


<210> 851
<211> 22
<212> RNA
<213> Homo sapiens

<400> 851
uacuuguaac ggagagcacu ag                                                22


<210> 852
<211> 22
<212> RNA
<213> Homo sapiens

<400> 852
caagggacca agcauucauu au                                                22


<210> 853
<211> 22
<212> RNA
<213> Homo sapiens

<400> 853
auaaugaaug cuuggucccu ug                                                22


<210> 854
<211> 22
<212> RNA
<213> Homo sapiens

<400> 854
caggaaggau uuagggacag gc                                                22


<210> 855
<211> 22
<212> RNA
<213> Homo sapiens

<400> 855
gccugucccu aaauccuucc ug                                                22


<210> 856
<211> 22
<212> RNA
<213> Homo sapiens

<400> 856
cuauuaagga cauuugugau uc                                                22


<210> 857
<211> 22
<212> RNA
<213> Homo sapiens

<400> 857
gaaucacaaa uguccuuaau ag                                                22


<210> 858
<211> 22
<212> RNA
<213> Homo sapiens

<400> 858
auuaaggaca uuugugauug au                                                22


<210> 859
<211> 22
<212> RNA
<213> Homo sapiens

<400> 859
aucaaucaca aauguccuua au                                                22


<210> 860
<211> 17
<212> RNA
<213> Homo sapiens

<400> 860
gaggcugagc ugaggag                                                      17


<210> 861
<211> 17
<212> RNA
<213> Homo sapiens

<400> 861
cuccucagcu cagccuc                                                      17


<210> 862
<211> 22
<212> RNA
<213> Homo sapiens

<400> 862
cgcgcggccg ugcucggagc ag                                                22


<210> 863
<211> 22
<212> RNA
<213> Homo sapiens

<400> 863
cugcuccgag cacggccgcg cg                                                22


<210> 864
<211> 21
<212> RNA
<213> Homo sapiens

<400> 864
agccaagugg aaguuacuuu a                                                 21


<210> 865
<211> 21
<212> RNA
<213> Homo sapiens

<400> 865
uaaaguaacu uccacuuggc u                                                 21


<210> 866
<211> 17
<212> RNA
<213> Homo sapiens

<400> 866
ggagugggcu ggugguu                                                      17


<210> 867
<211> 17
<212> RNA
<213> Homo sapiens

<400> 867
aaccaccagc ccacucc                                                      17


<210> 868
<211> 22
<212> RNA
<213> Homo sapiens

<400> 868
uuucuauuuc ucaguggggc uc                                                22


<210> 869
<211> 22
<212> RNA
<213> Homo sapiens

<400> 869
gagccccacu gagaaauaga aa                                                22


<210> 870
<211> 22
<212> RNA
<213> Homo sapiens

<400> 870
aacccagugg gcuauggaaa ug                                                22


<210> 871
<211> 22
<212> RNA
<213> Homo sapiens

<400> 871
cauuuccaua gcccacuggg uu                                                22


<210> 872
<211> 17
<212> RNA
<213> Homo sapiens

<400> 872
gggguggucu guuguug                                                      17


<210> 873
<211> 17
<212> RNA
<213> Homo sapiens

<400> 873
caacaacaga ccacccc                                                      17


<210> 874
<211> 20
<212> RNA
<213> Homo sapiens

<400> 874
aaaaggcggg agaagcccca                                                   20


<210> 875
<211> 20
<212> RNA
<213> Homo sapiens

<400> 875
uggggcuucu cccgccuuuu                                                   20


<210> 876
<211> 20
<212> RNA
<213> Homo sapiens

<400> 876
uaacggccgc gguacccuaa                                                   20


<210> 877
<211> 20
<212> RNA
<213> Homo sapiens

<400> 877
uuaggguacc gcggccguua                                                   20


<210> 878
<211> 17
<212> RNA
<213> Homo sapiens

<400> 878
gcugggcgag gcuggca                                                      17


<210> 879
<211> 17
<212> RNA
<213> Homo sapiens

<400> 879
ugccagccuc gcccagc                                                      17


<210> 880
<211> 19
<212> RNA
<213> Homo sapiens

<400> 880
agagcuggcu gaagggcag                                                    19


<210> 881
<211> 19
<212> RNA
<213> Homo sapiens

<400> 881
cugcccuuca gccagcucu                                                    19


<210> 882
<211> 18
<212> RNA
<213> Homo sapiens

<400> 882
agggggcggg cuccggcg                                                     18


<210> 883
<211> 18
<212> RNA
<213> Homo sapiens

<400> 883
cgccggagcc cgcccccu                                                     18


<210> 884
<211> 22
<212> RNA
<213> Homo sapiens

<400> 884
ucugguaaga gauuugggca ua                                                22


<210> 885
<211> 22
<212> RNA
<213> Homo sapiens

<400> 885
uaugcccaaa ucucuuacca ga                                                22


<210> 886
<211> 22
<212> RNA
<213> Homo sapiens

<400> 886
aauguggacu ggugugacca aa                                                22


<210> 887
<211> 22
<212> RNA
<213> Homo sapiens

<400> 887
uuuggucaca ccaguccaca uu                                                22


<210> 888
<211> 17
<212> RNA
<213> Homo sapiens

<400> 888
ggggcugggc gcgcgcc                                                      17


<210> 889
<211> 17
<212> RNA
<213> Homo sapiens

<400> 889
ggcgcgcgcc cagcccc                                                      17


<210> 890
<211> 21
<212> RNA
<213> Homo sapiens

<400> 890
agaaggccuu uccaucucug u                                                 21


<210> 891
<211> 21
<212> RNA
<213> Homo sapiens

<400> 891
acagagaugg aaaggccuuc u                                                 21


<210> 892
<211> 22
<212> RNA
<213> Homo sapiens

<400> 892
ccagacugug gcugaccaga gg                                                22


<210> 893
<211> 22
<212> RNA
<213> Homo sapiens

<400> 893
ccucugguca gccacagucu gg                                                22


<210> 894
<211> 21
<212> RNA
<213> Homo sapiens

<400> 894
aauguaaaca ggcuuuuugc u                                                 21


<210> 895
<211> 21
<212> RNA
<213> Homo sapiens

<400> 895
agcaaaaagc cuguuuacau u                                                 21


<210> 896
<211> 22
<212> RNA
<213> Homo sapiens

<400> 896
gaggaaacug aagcugagag gg                                                22


<210> 897
<211> 22
<212> RNA
<213> Homo sapiens

<400> 897
cccucucagc uucaguuucc uc                                                22


<210> 898
<211> 17
<212> RNA
<213> Homo sapiens

<400> 898
cuccgggacg gcugggc                                                      17


<210> 899
<211> 17
<212> RNA
<213> Homo sapiens

<400> 899
gcccagccgu cccggag                                                      17


<210> 900
<211> 22
<212> RNA
<213> Homo sapiens

<400> 900
ugggcuggca gggcaagugc ug                                                22


<210> 901
<211> 22
<212> RNA
<213> Homo sapiens

<400> 901
cagcacuugc ccugccagcc ca                                                22


<210> 902
<211> 17
<212> RNA
<213> Homo sapiens

<400> 902
aagacugaga ggaggga                                                      17


<210> 903
<211> 17
<212> RNA
<213> Homo sapiens

<400> 903
ucccuccucu cagucuu                                                      17


<210> 904
<211> 17
<212> RNA
<213> Homo sapiens

<400> 904
ugagguagua guuucuu                                                      17


<210> 905
<211> 17
<212> RNA
<213> Homo sapiens

<400> 905
aagaaacuac uaccuca                                                      17


<210> 906
<211> 21
<212> RNA
<213> Homo sapiens

<400> 906
uaugugaccu cggaugaauc a                                                 21


<210> 907
<211> 21
<212> RNA
<213> Homo sapiens

<400> 907
ugauucaucc gaggucacau a                                                 21


<210> 908
<211> 22
<212> RNA
<213> Homo sapiens

<400> 908
gcugaugaug auggugcuga ag                                                22


<210> 909
<211> 22
<212> RNA
<213> Homo sapiens

<400> 909
cuucagcacc aucaucauca gc                                                22


<210> 910
<211> 22
<212> RNA
<213> Homo sapiens

<400> 910
uuuaagcagg aaauagaauu ua                                                22


<210> 911
<211> 22
<212> RNA
<213> Homo sapiens

<400> 911
uaaauucuau uuccugcuua aa                                                22


<210> 912
<211> 22
<212> RNA
<213> Homo sapiens

<400> 912
ugugacaaua gagaugaaca ug                                                22


<210> 913
<211> 22
<212> RNA
<213> Homo sapiens

<400> 913
cauguucauc ucuauuguca ca                                                22


<210> 914
<211> 18
<212> RNA
<213> Homo sapiens

<400> 914
aggcugggcu gggacgga                                                     18


<210> 915
<211> 18
<212> RNA
<213> Homo sapiens

<400> 915
uccgucccag cccagccu                                                     18


<210> 916
<211> 20
<212> RNA
<213> Homo sapiens

<400> 916
aaaugggugg ucugaggcaa                                                   20


<210> 917
<211> 20
<212> RNA
<213> Homo sapiens

<400> 917
uugccucaga ccacccauuu                                                   20


<210> 918
<211> 20
<212> RNA
<213> Homo sapiens

<400> 918
cuggguuggg cugggcuggg                                                   20


<210> 919
<211> 20
<212> RNA
<213> Homo sapiens

<400> 919
cccagcccag cccaacccag                                                   20


<210> 920
<211> 17
<212> RNA
<213> Homo sapiens

<400> 920
gcggggcugg gcgcgcg                                                      17


<210> 921
<211> 17
<212> RNA
<213> Homo sapiens

<400> 921
cgcgcgccca gccccgc                                                      17


<210> 922
<211> 22
<212> RNA
<213> Homo sapiens

<400> 922
acuaaaggau auagaagguu uu                                                22


<210> 923
<211> 22
<212> RNA
<213> Homo sapiens

<400> 923
aaaaccuucu auauccuuua gu                                                22


<210> 924
<211> 22
<212> RNA
<213> Homo sapiens

<400> 924
ugagggagua ggauguaugg uu                                                22


<210> 925
<211> 22
<212> RNA
<213> Homo sapiens

<400> 925
aaccauacau ccuacucccu ca                                                22


<210> 926
<211> 22
<212> RNA
<213> Homo sapiens

<400> 926
gaagaacugu ugcauuugcc cu                                                22


<210> 927
<211> 22
<212> RNA
<213> Homo sapiens

<400> 927
agggcaaaug caacaguucu uc                                                22


<210> 928
<211> 22
<212> RNA
<213> Homo sapiens

<400> 928
cagggccuca cuguaucgcc ca                                                22


<210> 929
<211> 22
<212> RNA
<213> Homo sapiens

<400> 929
ugggcgauac agugaggccc ug                                                22


<210> 930
<211> 22
<212> RNA
<213> Homo sapiens

<400> 930
agacugacgg cuggaggccc au                                                22


<210> 931
<211> 22
<212> RNA
<213> Homo sapiens

<400> 931
augggccucc agccgucagu cu                                                22


<210> 932
<211> 18
<212> RNA
<213> Homo sapiens

<400> 932
acaggcagga uuggggaa                                                     18


<210> 933
<211> 18
<212> RNA
<213> Homo sapiens

<400> 933
uuccccaauc cugccugu                                                     18


<210> 934
<211> 22
<212> RNA
<213> Homo sapiens

<400> 934
aggacuggac ucccggcagc cc                                                22


<210> 935
<211> 22
<212> RNA
<213> Homo sapiens

<400> 935
gggcugccgg gaguccaguc cu                                                22


<210> 936
<211> 17
<212> RNA
<213> Homo sapiens

<400> 936
gggagaaggg ucggggc                                                      17


<210> 937
<211> 17
<212> RNA
<213> Homo sapiens

<400> 937
gccccgaccc uucuccc                                                      17


<210> 938
<211> 25
<212> RNA
<213> Homo sapiens

<400> 938
aaauaugaug aaacucacag cugag                                             25


<210> 939
<211> 25
<212> RNA
<213> Homo sapiens

<400> 939
cucagcugug aguuucauca uauuu                                             25


<210> 940
<211> 26
<212> RNA
<213> Homo sapiens

<400> 940
gcucagggau gauaacugug cugaga                                            26


<210> 941
<211> 26
<212> RNA
<213> Homo sapiens

<400> 941
ucucagcaca guuaucaucc cugagc                                            26


<210> 942
<211> 18
<212> RNA
<213> Homo sapiens

<400> 942
cagcagugcg cagggcug                                                     18


<210> 943
<211> 18
<212> RNA
<213> Homo sapiens

<400> 943
cagcccugcg cacugcug                                                     18


<210> 944
<211> 22
<212> RNA
<213> Homo sapiens

<400> 944
gcuaaggaag uccugugcuc ag                                                22


<210> 945
<211> 22
<212> RNA
<213> Homo sapiens

<400> 945
cugagcacag gacuuccuua gc                                                22


<210> 946
<211> 21
<212> RNA
<213> Homo sapiens

<400> 946
ugacucugcc uguaggccgg u                                                 21


<210> 947
<211> 21
<212> RNA
<213> Homo sapiens

<400> 947
accggccuac aggcagaguc a                                                 21


<210> 948
<211> 21
<212> RNA
<213> Homo sapiens

<400> 948
gaccgagagg gccucggcug u                                                 21


<210> 949
<211> 21
<212> RNA
<213> Homo sapiens

<400> 949
acagccgagg cccucucggu c                                                 21


<210> 950
<211> 21
<212> RNA
<213> Homo sapiens

<400> 950
ggggggaugu gcaugcuggu u                                                 21


<210> 951
<211> 21
<212> RNA
<213> Homo sapiens

<400> 951
aaccagcaug cacauccccc c                                                 21


<210> 952
<211> 22
<212> RNA
<213> Homo sapiens

<400> 952
uggucugcaa agagaugacu gu                                                22


<210> 953
<211> 22
<212> RNA
<213> Homo sapiens

<400> 953
acagucaucu cuuugcagac ca                                                22


<210> 954
<211> 22
<212> RNA
<213> Homo sapiens

<400> 954
ucauuauaug uaugaucugg ac                                                22


<210> 955
<211> 22
<212> RNA
<213> Homo sapiens

<400> 955
guccagauca uacauauaau ga                                                22


<210> 956
<211> 18
<212> RNA
<213> Homo sapiens

<400> 956
cccagcagga cgggagcg                                                     18


<210> 957
<211> 18
<212> RNA
<213> Homo sapiens

<400> 957
cgcucccguc cugcuggg                                                     18


<210> 958
<211> 17
<212> RNA
<213> Homo sapiens

<400> 958
auggagaagg cuucuga                                                      17


<210> 959
<211> 17
<212> RNA
<213> Homo sapiens

<400> 959
ucagaagccu ucuccau                                                      17


<210> 960
<211> 17
<212> RNA
<213> Homo sapiens

<400> 960
ccccggggag cccggcg                                                      17


<210> 961
<211> 17
<212> RNA
<213> Homo sapiens

<400> 961
cgccgggcuc cccgggg                                                      17


<210> 962
<211> 22
<212> RNA
<213> Homo sapiens

<400> 962
uggaaggagg uugccggacg cu                                                22


<210> 963
<211> 22
<212> RNA
<213> Homo sapiens

<400> 963
agcguccggc aaccuccuuc ca                                                22


<210> 964
<211> 17
<212> RNA
<213> Homo sapiens

<400> 964
ggauggagga ggggucu                                                      17


<210> 965
<211> 17
<212> RNA
<213> Homo sapiens

<400> 965
agaccccucc uccaucc                                                      17


<210> 966
<211> 17
<212> RNA
<213> Homo sapiens

<400> 966
guggaccugg cugggac                                                      17


<210> 967
<211> 17
<212> RNA
<213> Homo sapiens

<400> 967
gucccagcca gguccac                                                      17


<210> 968
<211> 21
<212> RNA
<213> Homo sapiens

<400> 968
ucgugcauau aucuaccaca u                                                 21


<210> 969
<211> 21
<212> RNA
<213> Homo sapiens

<400> 969
augugguaga uauaugcacg a                                                 21


<210> 970
<211> 21
<212> RNA
<213> Homo sapiens

<400> 970
ugugguagau auaugcacga u                                                 21


<210> 971
<211> 21
<212> RNA
<213> Homo sapiens

<400> 971
aucgugcaua uaucuaccac a                                                 21


<210> 972
<211> 22
<212> RNA
<213> Homo sapiens

<400> 972
ugagccgagc ugagcuuagc ug                                                22


<210> 973
<211> 22
<212> RNA
<213> Homo sapiens

<400> 973
cagcuaagcu cagcucggcu ca                                                22


<210> 974
<211> 22
<212> RNA
<213> Homo sapiens

<400> 974
gagcuuggau gagcugggcu ga                                                22


<210> 975
<211> 22
<212> RNA
<213> Homo sapiens

<400> 975
ucagcccagc ucauccaagc uc                                                22


<210> 976
<211> 22
<212> RNA
<213> Homo sapiens

<400> 976
gcugaacugg gcugagcugg gc                                                22


<210> 977
<211> 22
<212> RNA
<213> Homo sapiens

<400> 977
gcccagcuca gcccaguuca gc                                                22


<210> 978
<211> 21
<212> RNA
<213> Homo sapiens

<400> 978
uuaguccugc cuguagguuu a                                                 21


<210> 979
<211> 21
<212> RNA
<213> Homo sapiens

<400> 979
uaaaccuaca ggcaggacua a                                                 21


<210> 980
<211> 20
<212> RNA
<213> Homo sapiens

<400> 980
uugggcuggg cuggguuggg                                                   20


<210> 981
<211> 20
<212> RNA
<213> Homo sapiens

<400> 981
cccaacccag cccagcccaa                                                   20


<210> 982
<211> 20
<212> RNA
<213> Homo sapiens

<400> 982
uaggaugggg gugagaggug                                                   20


<210> 983
<211> 20
<212> RNA
<213> Homo sapiens

<400> 983
caccucucac ccccauccua                                                   20


<210> 984
<211> 22
<212> RNA
<213> Homo sapiens

<400> 984
aaaaguaauu guggauuuug cu                                                22


<210> 985
<211> 22
<212> RNA
<213> Homo sapiens

<400> 985
agcaaaaucc acaauuacuu uu                                                22


<210> 986
<211> 22
<212> RNA
<213> Homo sapiens

<400> 986
caaaaaccgg caauuacuuu ug                                                22


<210> 987
<211> 22
<212> RNA
<213> Homo sapiens

<400> 987
caaaaguaau ugccgguuuu ug                                                22


<210> 988
<211> 22
<212> RNA
<213> Homo sapiens

<400> 988
gaaaacgaca augacuuuug ca                                                22


<210> 989
<211> 22
<212> RNA
<213> Homo sapiens

<400> 989
ugcaaaaguc auugucguuu uc                                                22


<210> 990
<211> 21
<212> RNA
<213> Homo sapiens

<400> 990
caaaaacugc aauuacuuuc a                                                 21


<210> 991
<211> 21
<212> RNA
<213> Homo sapiens

<400> 991
ugaaaguaau ugcaguuuuu g                                                 21


<210> 992
<211> 21
<212> RNA
<213> Homo sapiens

<400> 992
aaagguaauu gugguuucug c                                                 21


<210> 993
<211> 21
<212> RNA
<213> Homo sapiens

<400> 993
gcagaaacca caauuaccuu u                                                 21


<210> 994
<211> 22
<212> RNA
<213> Homo sapiens

<400> 994
caaaaacugc aguuacuuuu gc                                                22


<210> 995
<211> 22
<212> RNA
<213> Homo sapiens

<400> 995
gcaaaaguaa cugcaguuuu ug                                                22


<210> 996
<211> 20
<212> RNA
<213> Homo sapiens

<400> 996
aaaagugauu gcaguguuug                                                   20


<210> 997
<211> 20
<212> RNA
<213> Homo sapiens

<400> 997
caaacacugc aaucacuuuu                                                   20


<210> 998
<211> 22
<212> RNA
<213> Homo sapiens

<400> 998
aaagguaauu gcaguuuuuc cc                                                22


<210> 999
<211> 22
<212> RNA
<213> Homo sapiens

<400> 999
gggaaaaacu gcaauuaccu uu                                                22


<210> 1000
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1000
uaaaaacugc aauuacuuuu a                                                 21


<210> 1001
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1001
uaaaaguaau ugcaguuuuu a                                                 21


<210> 1002
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1002
ugcaaaagua auugcaguuu uug                                               23


<210> 1003
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1003
caaaaacugc aauuacuuuu gca                                               23


<210> 1004
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1004
aaaaguaacu gcgguuuuug a                                                 21


<210> 1005
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1005
ucaaaaaccg caguuacuuu u                                                 21


<210> 1006
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1006
aacggcaaug acuuuuguac ca                                                22


<210> 1007
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1007
ugguacaaaa gucauugccg uu                                                22


<210> 1008
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1008
caaaaacugc aguuacuuuu gu                                                22


<210> 1009
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1009
acaaaaguaa cugcaguuuu ug                                                22


<210> 1010
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1010
aaaaguaauu gcgguuuuug cc                                                22


<210> 1011
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1011
ggcaaaaacc gcaauuacuu uu                                                22


<210> 1012
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1012
aaaaggcauu gugguuuuug                                                   20


<210> 1013
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1013
caaaaaccac aaugccuuuu                                                   20


<210> 1014
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1014
cggcccgggc ugcugcuguu ccu                                               23


<210> 1015
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1015
aggaacagca gcagcccggg ccg                                               23


<210> 1016
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1016
agagguauag ggcaugggaa                                                   20


<210> 1017
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1017
uucccaugcc cuauaccucu                                                   20


<210> 1018
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1018
uuccuaugca uauacuucuu ug                                                22


<210> 1019
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1019
caaagaagua uaugcauagg aa                                                22


<210> 1020
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1020
aucauagagg aaaauccaug uu                                                22


<210> 1021
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1021
aacauggauu uuccucuaug au                                                22


<210> 1022
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1022
cguggauauu ccuucuaugu uu                                                22


<210> 1023
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1023
aaacauagaa ggaauaucca cg                                                22


<210> 1024
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1024
ugaguauuac auggccaauc uc                                                22


<210> 1025
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1025
gagauuggcc auguaauacu ca                                                22


<210> 1026
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1026
cuuccgcccc gccgggcguc g                                                 21


<210> 1027
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1027
cgacgcccgg cggggcggaa g                                                 21


<210> 1028
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1028
uagcuuauca gacugauguu ga                                                22


<210> 1029
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1029
ucaacaucag ucugauaagc ua                                                22


<210> 1030
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1030
cacuagauug ugagcuccug ga                                                22


<210> 1031
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1031
uccaggagcu cacaaucuag ug                                                22


<210> 1032
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1032
aaggagcuca cagucuauug ag                                                22


<210> 1033
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1033
cucaauagac ugugagcucc uu                                                22


<210> 1034
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1034
uacgucaucg uugucaucgu ca                                                22


<210> 1035
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1035
ugacgaugac aacgaugacg ua                                                22


<210> 1036
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1036
cacgcucaug cacacaccca ca                                                22


<210> 1037
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1037
ugugggugug ugcaugagcg ug                                                22


<210> 1038
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1038
caacaccagu cgaugggcug u                                                 21


<210> 1039
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1039
acagcccauc gacugguguu g                                                 21


<210> 1040
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1040
uucaccaccu ucuccaccca gc                                                22


<210> 1041
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1041
gcugggugga gaagguggug aa                                                22


<210> 1042
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1042
cggguagaga gggcaguggg agg                                               23


<210> 1043
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1043
ccucccacug cccucucuac ccg                                               23


<210> 1044
<211> 18
<212> RNA
<213> Homo sapiens

<400> 1044
aauccuugcu accugggu                                                     18


<210> 1045
<211> 18
<212> RNA
<213> Homo sapiens

<400> 1045
acccagguag caaggauu                                                     18


<210> 1046
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1046
caauuuagug ugugugauau uu                                                22


<210> 1047
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1047
aaauaucaca cacacuaaau ug                                                22


<210> 1048
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1048
uauugcacau uacuaaguug ca                                                22


<210> 1049
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1049
ugcaacuuag uaaugugcaa ua                                                22


<210> 1050
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1050
ccuauucuug auuacuuguu uc                                                22


<210> 1051
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1051
gaaacaagua aucaagaaua gg                                                22


<210> 1052
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1052
uucaaguaau ccaggauagg cu                                                22


<210> 1053
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1053
agccuauccu ggauuacuug aa                                                22


<210> 1054
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1054
ccaguuaccg cuuccgcuac cgc                                               23


<210> 1055
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1055
gcgguagcgg aagcgguaac ugg                                               23


<210> 1056
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1056
gauuucagug gagugaaguu c                                                 21


<210> 1057
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1057
gaacuucacu ccacugaaau c                                                 21


<210> 1058
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1058
uccuucauuc caccggaguc ug                                                22


<210> 1059
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1059
cagacuccgg uggaaugaag ga                                                22


<210> 1060
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1060
aaaauggugc ccuagugacu aca                                               23


<210> 1061
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1061
uguagucacu agggcaccau uuu                                               23


<210> 1062
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1062
caagucacua gugguuccgu u                                                 21


<210> 1063
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1063
aacggaacca cuagugacuu g                                                 21


<210> 1064
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1064
ccaguauuaa cugugcugcu ga                                                22


<210> 1065
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1065
ucagcagcac aguuaauacu gg                                                22


<210> 1066
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1066
ucccccaggu gugauucuga uuu                                               23


<210> 1067
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1067
aaaucagaau cacaccuggg gga                                               23


<210> 1068
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1068
aaaagcuggg uugagagggc ga                                                22


<210> 1069
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1069
ucgcccucuc aacccagcuu uu                                                22


<210> 1070
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1070
uggacggaga acugauaagg gu                                                22


<210> 1071
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1071
acccuuauca guucuccguc ca                                                22


<210> 1072
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1072
uggugggccg cagaacaugu gc                                                22


<210> 1073
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1073
gcacauguuc ugcggcccac ca                                                22


<210> 1074
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1074
agugccugcu augugccagg ca                                                22


<210> 1075
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1075
ugccuggcac auagcaggca cu                                                22


<210> 1076
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1076
cuuggcaccu agcaagcacu ca                                                22


<210> 1077
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1077
ugagugcuug cuaggugcca ag                                                22


<210> 1078
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1078
uuauugcuua agaauacgcg uag                                               23


<210> 1079
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1079
cuacgcguau ucuuaagcaa uaa                                               23


<210> 1080
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1080
uugcauaguc acaaaaguga uc                                                22


<210> 1081
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1081
gaucacuuuu gugacuaugc aa                                                22


<210> 1082
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1082
gugaauuacc gaagggccau aa                                                22


<210> 1083
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1083
uuauggcccu ucgguaauuc ac                                                22


<210> 1084
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1084
uauggcacug guagaauuca cu                                                22


<210> 1085
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1085
agugaauucu accagugcca ua                                                22


<210> 1086
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1086
ugauauguuu gauauauuag gu                                                22


<210> 1087
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1087
accuaauaua ucaaacauau ca                                                22


<210> 1088
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1088
ugauauguuu gauauugggu u                                                 21


<210> 1089
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1089
aacccaauau caaacauauc a                                                 21


<210> 1090
<211> 18
<212> RNA
<213> Homo sapiens

<400> 1090
agcaggugcg gggcggcg                                                     18


<210> 1091
<211> 18
<212> RNA
<213> Homo sapiens

<400> 1091
cgccgccccg caccugcu                                                     18


<210> 1092
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1092
cagugcaagu guagaugccg a                                                 21


<210> 1093
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1093
ucggcaucua cacuugcacu g                                                 21


<210> 1094
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1094
uauguaauau gguccacauc uu                                                22


<210> 1095
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1095
aagaugugga ccauauuaca ua                                                22


<210> 1096
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1096
aauauaacac agauggccug u                                                 21


<210> 1097
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1097
acaggccauc uguguuauau u                                                 21


<210> 1098
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1098
aucgggaaug ucguguccgc cc                                                22


<210> 1099
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1099
gggcggacac gacauucccg au                                                22


<210> 1100
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1100
aaugacacga ucacucccgu uga                                               23


<210> 1101
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1101
ucaacgggag ugaucguguc auu                                               23


<210> 1102
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1102
uacucaggag aguggcaauc ac                                                22


<210> 1103
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1103
gugauugcca cucuccugag ua                                                22


<210> 1104
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1104
uggaagacua gugauuuugu ugu                                               23


<210> 1105
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1105
acaacaaaau cacuagucuu cca                                               23


<210> 1106
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1106
auaaagcuag auaaccgaaa gu                                                22


<210> 1107
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1107
acuuucgguu aucuagcuuu au                                                22


<210> 1108
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1108
ucuuugguua ucuagcugua uga                                               23


<210> 1109
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1109
ucauacagcu agauaaccaa aga                                               23


<210> 1110
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1110
acaggugagg uucuugggag cc                                                22


<210> 1111
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1111
ggcucccaag aaccucaccu gu                                                22


<210> 1112
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1112
ucccugagac ccuuuaaccu guga                                              24


<210> 1113
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1113
ucacagguua aagggucuca ggga                                              24


<210> 1114
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1114
caacaaaucc cagucuaccu aa                                                22


<210> 1115
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1115
uuagguagac ugggauuugu ug                                                22


<210> 1116
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1116
cguguucaca gcggaccuug au                                                22


<210> 1117
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1117
aucaaggucc gcugugaaca cg                                                22


<210> 1118
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1118
uaaggcacgc ggugaaugcc                                                   20


<210> 1119
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1119
ggcauucacc gcgugccuua                                                   20


<210> 1120
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1120
aacacaccug guuaaccucu uu                                                22


<210> 1121
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1121
aaagagguua accaggugug uu                                                22


<210> 1122
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1122
uaacagucua cagccauggu cg                                                22


<210> 1123
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1123
cgaccauggc uguagacugu ua                                                22


<210> 1124
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1124
accguggcuu ucgauuguua cu                                                22


<210> 1125
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1125
aguaacaauc gaaagccacg gu                                                22


<210> 1126
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1126
uaacagucuc cagucacggc c                                                 21


<210> 1127
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1127
ggccgugacu ggagacuguu a                                                 21


<210> 1128
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1128
accuuggcuc uagacugcuu acu                                               23


<210> 1129
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1129
aguaagcagu cuagagccaa ggu                                               23


<210> 1130
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1130
ucucacacag aaaucgcacc cgu                                               23


<210> 1131
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1131
acgggugcga uuucugugug aga                                               23


<210> 1132
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1132
ugguugacca uagaacaugc gc                                                22


<210> 1133
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1133
gcgcauguuc uauggucaac ca                                                22


<210> 1134
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1134
caguaacaaa gauucauccu ugu                                               23


<210> 1135
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1135
acaaggauga aucuuuguua cug                                               23


<210> 1136
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1136
agaguugagu cuggacgucc cg                                                22


<210> 1137
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1137
cgggacgucc agacucaacu cu                                                22


<210> 1138
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1138
agaauugugg cuggacaucu gu                                                22


<210> 1139
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1139
acagaugucc agccacaauu cu                                                22


<210> 1140
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1140
ugauugucca aacgcaauuc u                                                 21


<210> 1141
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1141
agaauugcgu uuggacaauc a                                                 21


<210> 1142
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1142
uauagggauu ggagccgugg cg                                                22


<210> 1143
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1143
cgccacggcu ccaaucccua ua                                                22


<210> 1144
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1144
uauggcuuuu uauuccuaug uga                                               23


<210> 1145
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1145
ucacauagga auaaaaagcc aua                                               23


<210> 1146
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1146
auguagggcu aaaagccaug gg                                                22


<210> 1147
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1147
cccauggcuu uuagcccuac au                                                22


<210> 1148
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1148
uauggcuuuu cauuccuaug uga                                               23


<210> 1149
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1149
ucacauagga augaaaagcc aua                                               23


<210> 1150
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1150
aaccaucgac cguugagugg ac                                                22


<210> 1151
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1151
guccacucaa cggucgaugg uu                                                22


<210> 1152
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1152
aacauucaac cugucgguga gu                                                22


<210> 1153
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1153
acucaccgac agguugaaug uu                                                22


<210> 1154
<211> 25
<212> RNA
<213> Homo sapiens

<400> 1154
cuuccagacg cuccgcccca cgucg                                             25


<210> 1155
<211> 25
<212> RNA
<213> Homo sapiens

<400> 1155
cgacgugggg cggagcgucu ggaag                                             25


<210> 1156
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1156
aacaacaaaa ucacuagucu ucca                                              24


<210> 1157
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1157
uggaagacua gugauuuugu uguu                                              24


<210> 1158
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1158
agguagacug ggauuuguug uu                                                22


<210> 1159
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1159
aacaacaaau cccagucuac cu                                                22


<210> 1160
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1160
aaacaccauu gucacacucc ac                                                22


<210> 1161
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1161
guggagugug acaauggugu uu                                                22


<210> 1162
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1162
uuuaguguga uaauggcguu uga                                               23


<210> 1163
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1163
ucaaacgcca uuaucacacu aaa                                               23


<210> 1164
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1164
uauggaaaga cuuugccacu cu                                                22


<210> 1165
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1165
agaguggcaa agucuuucca ua                                                22


<210> 1166
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1166
aguggcaaag ucuuuccaua u                                                 21


<210> 1167
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1167
auauggaaag acuuugccac u                                                 21


<210> 1168
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1168
cagcccggau cccagcccac uu                                                22


<210> 1169
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1169
aagugggcug ggauccgggc ug                                                22


<210> 1170
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1170
guggguuggg gcgggcucug                                                   20


<210> 1171
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1171
cagagcccgc cccaacccac                                                   20


<210> 1172
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1172
uucgggcugg ccugcugcuc cgg                                               23


<210> 1173
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1173
ccggagcagc aggccagccc gaa                                               23


<210> 1174
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1174
ugugcagcag gccaaccgag a                                                 21


<210> 1175
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1175
ucucgguugg ccugcugcac a                                                 21


<210> 1176
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1176
cagggcagga agaaguggac aa                                                22


<210> 1177
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1177
uuguccacuu cuuccugccc ug                                                22


<210> 1178
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1178
guccacuucu gccugcccug cc                                                22


<210> 1179
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1179
ggcagggcag gcagaagugg ac                                                22


<210> 1180
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1180
uuuggacaga aaacacgcag gu                                                22


<210> 1181
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1181
accugcgugu uuucugucca aa                                                22


<210> 1182
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1182
ccugcguguu uucuguccaa                                                   20


<210> 1183
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1183
uuggacagaa aacacgcagg                                                   20


<210> 1184
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1184
ugccgcccuc ucgcugcucu ag                                                22


<210> 1185
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1185
cuagagcagc gagagggcgg ca                                                22


<210> 1186
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1186
gagggcagcg uggguguggc gga                                               23


<210> 1187
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1187
uccgccacac ccacgcugcc cuc                                               23


<210> 1188
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1188
aggagcuagc caggcauaug ca                                                22


<210> 1189
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1189
ugcauaugcc uggcuagcuc cu                                                22


<210> 1190
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1190
auaugccugg cuagcuccuc                                                   20


<210> 1191
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1191
gaggagcuag ccaggcauau                                                   20


<210> 1192
<211> 19
<212> RNA
<213> Homo sapiens

<400> 1192
cggcgcgacc ggcccgggg                                                    19


<210> 1193
<211> 19
<212> RNA
<213> Homo sapiens

<400> 1193
ccccgggccg gucgcgccg                                                    19


<210> 1194
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1194
ucuugaaguc agaacccgca a                                                 21


<210> 1195
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1195
uugcggguuc ugacuucaag a                                                 21


<210> 1196
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1196
aacucguguu caaagccuuu ag                                                22


<210> 1197
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1197
cuaaaggcuu ugaacacgag uu                                                22


<210> 1198
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1198
ccuggacacc gcucagccgg ccg                                               23


<210> 1199
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1199
cggccggcug agcggugucc agg                                               23


<210> 1200
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1200
acucggcugc gguggacaag u                                                 21


<210> 1201
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1201
acuuguccac cgcagccgag u                                                 21


<210> 1202
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1202
ucacucucac cuugcuuugc                                                   20


<210> 1203
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1203
gcaaagcaag gugagaguga                                                   20


<210> 1204
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1204
uugcuaagua ggcugagauu ga                                                22


<210> 1205
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1205
ucaaucucag ccuacuuagc aa                                                22


<210> 1206
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1206
cacccccugu uuccuggccc ac                                                22


<210> 1207
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1207
gugggccagg aaacaggggg ug                                                22


<210> 1208
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1208
ugggccaggg agcagcuggu ggg                                               23


<210> 1209
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1209
cccaccagcu gcucccuggc cca                                               23


<210> 1210
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1210
ugcccaugcc auacuuuugc cuca                                              24


<210> 1211
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1211
ugaggcaaaa guauggcaug ggca                                              24


<210> 1212
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1212
auggcaucgu ccccuggugg cu                                                22


<210> 1213
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1213
agccaccagg ggacgaugcc au                                                22


<210> 1214
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1214
gacacaugac cauaaaugcu aa                                                22


<210> 1215
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1215
uuagcauuua uggucaugug uc                                                22


<210> 1216
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1216
uggagagaga aaagagacag aag                                               23


<210> 1217
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1217
cuucugucuc uuuucucucu cca                                               23


<210> 1218
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1218
agacaguagu ucuugccugg uu                                                22


<210> 1219
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1219
aaccaggcaa gaacuacugu cu                                                22


<210> 1220
<211> 19
<212> RNA
<213> Homo sapiens

<400> 1220
accaggcaag aaauauugu                                                    19


<210> 1221
<211> 19
<212> RNA
<213> Homo sapiens

<400> 1221
acaauauuuc uugccuggu                                                    19


<210> 1222
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1222
auugucccuc ucccuuccca g                                                 21


<210> 1223
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1223
cugggaaggg agagggacaa u                                                 21


<210> 1224
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1224
acugggaaga ggagcugagg ga                                                22


<210> 1225
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1225
ucccucagcu ccucuuccca gu                                                22


<210> 1226
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1226
gaagauggug cugugcugag gaa                                               23


<210> 1227
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1227
uuccucagca cagcaccauc uuc                                               23


<210> 1228
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1228
ugugggacug caaaugggag                                                   20


<210> 1229
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1229
cucccauuug cagucccaca                                                   20


<210> 1230
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1230
ucugaggccu gccucucccc a                                                 21


<210> 1231
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1231
uggggagagg caggccucag a                                                 21


<210> 1232
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1232
ugggcgaggg gugggcucuc agag                                              24


<210> 1233
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1233
cucugagagc ccaccccucg ccca                                              24


<210> 1234
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1234
agguagaaug aggccugaca u                                                 21


<210> 1235
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1235
augucaggcc ucauucuacc u                                                 21


<210> 1236
<211> 19
<212> RNA
<213> Homo sapiens

<400> 1236
ucaggccucu uucuaccuu                                                    19


<210> 1237
<211> 19
<212> RNA
<213> Homo sapiens

<400> 1237
aagguagaaa gaggccuga                                                    19


<210> 1238
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1238
cggggugggu gaggucgggc                                                   20


<210> 1239
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1239
gcccgaccuc acccaccccg                                                   20


<210> 1240
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1240
guucuguuaa cccauccccu ca                                                22


<210> 1241
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1241
ugaggggaug gguuaacaga ac                                                22


<210> 1242
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1242
aggggacugg uuaauagaac ua                                                22


<210> 1243
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1243
uaguucuauu aaccaguccc cu                                                22


<210> 1244
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1244
uggaguuaag gguugcuugg aga                                               23


<210> 1245
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1245
ucuccaagca acccuuaacu cca                                               23


<210> 1246
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1246
ucucugagca aggcuuaaca cc                                                22


<210> 1247
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1247
gguguuaagc cuugcucaga ga                                                22


<210> 1248
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1248
ugugggaucu ggaggcaucu gg                                                22


<210> 1249
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1249
ccagaugccu ccagauccca ca                                                22


<210> 1250
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1250
acccucguca gguccccggg g                                                 21


<210> 1251
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1251
ccccggggac cugacgaggg u                                                 21


<210> 1252
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1252
caccggggau ggcagagggu cg                                                22


<210> 1253
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1253
cgacccucug ccauccccgg ug                                                22


<210> 1254
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1254
ugggcugagg gcaggaggcc ugu                                               23


<210> 1255
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1255
acaggccucc ugcccucagc cca                                               23


<210> 1256
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1256
aauguggaag uggucugagg cau                                               23


<210> 1257
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1257
augccucaga ccacuuccac auu                                               23


<210> 1258
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1258
gugagugugg auccuggagg aau                                               23


<210> 1259
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1259
auuccuccag gauccacacu cac                                               23


<210> 1260
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1260
uuucuucuua gacauggcaa cg                                                22


<210> 1261
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1261
cguugccaug ucuaagaaga aa                                                22


<210> 1262
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1262
cugccauguc uaagaagaaa ac                                                22


<210> 1263
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1263
guuuucuucu uagacauggc ag                                                22


<210> 1264
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1264
uuucuucuua gacauggcag cu                                                22


<210> 1265
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1265
agcugccaug ucuaagaaga aa                                                22


<210> 1266
<211> 19
<212> RNA
<213> Homo sapiens

<400> 1266
uugccauguc uaagaagaa                                                    19


<210> 1267
<211> 19
<212> RNA
<213> Homo sapiens

<400> 1267
uucuucuuag acauggcaa                                                    19


<210> 1268
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1268
ugcagcucug guggaaaaug gag                                               23


<210> 1269
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1269
cuccauuuuc caccagagcu gca                                               23


<210> 1270
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1270
caggauccac agagcuaguc ca                                                22


<210> 1271
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1271
uggacuagcu cuguggaucc ug                                                22


<210> 1272
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1272
aacuagcucu guggauccug ac                                                22


<210> 1273
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1273
gucaggaucc acagagcuag uu                                                22


<210> 1274
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1274
aaagauggac aauuggcuaa au                                                22


<210> 1275
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1275
auuuagccaa uuguccaucu uu                                                22


<210> 1276
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1276
agcugagcuc cauggacgug cagu                                              24


<210> 1277
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1277
acugcacguc cauggagcuc agcu                                              24


<210> 1278
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1278
cuuccggucu gugagccccg uc                                                22


<210> 1279
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1279
gacggggcuc acagaccgga ag                                                22


<210> 1280
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1280
uggggugccc acuccgcaag uu                                                22


<210> 1281
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1281
aacuugcgga gugggcaccc ca                                                22


<210> 1282
<211> 26
<212> RNA
<213> Homo sapiens

<400> 1282
cucggccgcg gcgcguagcc cccgcc                                            26


<210> 1283
<211> 26
<212> RNA
<213> Homo sapiens

<400> 1283
ggcgggggcu acgcgccgcg gccgag                                            26


<210> 1284
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1284
cugggggacg cgugagcgcg agc                                               23


<210> 1285
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1285
gcucgcgcuc acgcgucccc cag                                               23


<210> 1286
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1286
cauacaaucu gacauguauu u                                                 21


<210> 1287
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1287
aaauacaugu cagauuguau g                                                 21


<210> 1288
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1288
auacauguca gauuguaugc c                                                 21


<210> 1289
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1289
ggcauacaau cugacaugua u                                                 21


<210> 1290
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1290
ucccuccuuc uguccccaca g                                                 21


<210> 1291
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1291
cuguggggac agaaggaggg a                                                 21


<210> 1292
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1292
acuggggagc agaaggagaa cc                                                22


<210> 1293
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1293
gguucuccuu cugcucccca gu                                                22


<210> 1294
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1294
gaaaauccuu uuuguuuuuc cag                                               23


<210> 1295
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1295
cuggaaaaac aaaaaggauu uuc                                               23


<210> 1296
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1296
agggaaaaaa aaaaggauuu guc                                               23


<210> 1297
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1297
gacaaauccu uuuuuuuuuc ccu                                               23


<210> 1298
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1298
uguguccggg aaguggagga gg                                                22


<210> 1299
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1299
ccuccuccac uucccggaca ca                                                22


<210> 1300
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1300
ugaaguuaca ucauggucgc uu                                                22


<210> 1301
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1301
aagcgaccau gauguaacuu ca                                                22


<210> 1302
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1302
aagcgaccau gauguaacuu ca                                                22


<210> 1303
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1303
ugaaguuaca ucauggucgc uu                                                22


<210> 1304
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1304
uuagugcaua gucuuugguc u                                                 21


<210> 1305
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1305
agaccaaaga cuaugcacua a                                                 21


<210> 1306
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1306
accgaagacu gugcgcuaau cu                                                22


<210> 1307
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1307
agauuagcgc acagucuucg gu                                                22


<210> 1308
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1308
uuacacagcu ggacagaggc a                                                 21


<210> 1309
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1309
ugccucuguc cagcugugua a                                                 21


<210> 1310
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1310
uccaggcagg agccggacug ga                                                22


<210> 1311
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1311
uccaguccgg cuccugccug ga                                                22


<210> 1312
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1312
cugggcucgg gacgcgcggc u                                                 21


<210> 1313
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1313
agccgcgcgu cccgagccca g                                                 21


<210> 1314
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1314
ggggcuguga uugaccagca gg                                                22


<210> 1315
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1315
ccugcugguc aaucacagcc cc                                                22


<210> 1316
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1316
cacuguuuca ccacuggcuc uu                                                22


<210> 1317
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1317
aagagccagu ggugaaacag ug                                                22


<210> 1318
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1318
gagccagugg ugagacagug a                                                 21


<210> 1319
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1319
ucacugucuc accacuggcu c                                                 21


<210> 1320
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1320
aagguauugu ucagacuuau ga                                                22


<210> 1321
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1321
ucauaagucu gaacaauacc uu                                                22


<210> 1322
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1322
ucugugauag agauucuuug cu                                                22


<210> 1323
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1323
agcaaagaau cucuaucaca ga                                                22


<210> 1324
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1324
ucugaauugu aagaguuguu a                                                 21


<210> 1325
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1325
uaacaacucu uacaauucag a                                                 21


<210> 1326
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1326
agaacucuug cagucuuaga ugu                                               23


<210> 1327
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1327
acaucuaaga cugcaagagu ucu                                               23


<210> 1328
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1328
aacgggaaug caggcuguau cu                                                22


<210> 1329
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1329
agauacagcc ugcauucccg uu                                                22


<210> 1330
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1330
ucugaguucc uggagccugg ucu                                               23


<210> 1331
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1331
agaccaggcu ccaggaacuc aga                                               23


<210> 1332
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1332
uggagaucca gugcucgccc gau                                               23


<210> 1333
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1333
aucgggcgag cacuggaucu cca                                               23


<210> 1334
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1334
uguugcaagu cgguggagac gu                                                22


<210> 1335
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1335
acgucuccac cgacuugcaa ca                                                22


<210> 1336
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1336
cucucuacug acuugcaaca ua                                                22


<210> 1337
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1337
uauguugcaa gucaguagag ag                                                22


<210> 1338
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1338
ucucccuucc ugcccuggcu ag                                                22


<210> 1339
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1339
cuagccaggg caggaaggga ga                                                22


<210> 1340
<211> 26
<212> RNA
<213> Homo sapiens

<400> 1340
cccagggcuu ggaguggggc aagguu                                            26


<210> 1341
<211> 26
<212> RNA
<213> Homo sapiens

<400> 1341
aaccuugccc cacuccaagc ccuggg                                            26


<210> 1342
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1342
uaucugcugg gcuuucuggu guu                                               23


<210> 1343
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1343
aacaccagaa agcccagcag aua                                               23


<210> 1344
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1344
uggcuguugg agggggcagg c                                                 21


<210> 1345
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1345
gccugccccc uccaacagcc a                                                 21


<210> 1346
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1346
cagcccuccu cccgcaccca aa                                                22


<210> 1347
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1347
uuugggugcg ggaggagggc ug                                                22


<210> 1348
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1348
uaggggcagc agaggaccug gg                                                22


<210> 1349
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1349
cccagguccu cugcugcccc ua                                                22


<210> 1350
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1350
uugaggagac augguggggg cc                                                22


<210> 1351
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1351
ggcccccacc augucuccuc aa                                                22


<210> 1352
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1352
gcagcccagc ugaggccucu g                                                 21


<210> 1353
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1353
cagaggccuc agcugggcug c                                                 21


<210> 1354
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1354
gagcaggcga ggcugggcug aa                                                22


<210> 1355
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1355
uucagcccag ccucgccugc uc                                                22


<210> 1356
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1356
ccagccacgg acugagagug cau                                               23


<210> 1357
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1357
augcacucuc aguccguggc ugg                                               23


<210> 1358
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1358
guccuccagg ccaugagcug cgg                                               23


<210> 1359
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1359
ccgcagcuca uggccuggag gac                                               23


<210> 1360
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1360
ucaggcagug uggguaucag au                                                22


<210> 1361
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1361
aucugauacc cacacugccu ga                                                22


<210> 1362
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1362
ugagagugga auucacagua uuu                                               23


<210> 1363
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1363
aaauacugug aauuccacuc uca                                               23


<210> 1364
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1364
auacugugaa uuucacuguc aca                                               23


<210> 1365
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1365
ugugacagug aaauucacag uau                                               23


<210> 1366
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1366
caaauggaca ggauaacacc u                                                 21


<210> 1367
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1367
agguguuauc cuguccauuu g                                                 21


<210> 1368
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1368
agguguuauc cuauccauuu gc                                                22


<210> 1369
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1369
gcaaauggau aggauaacac cu                                                22


<210> 1370
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1370
ugaucucacc gcugccuccu uc                                                22


<210> 1371
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1371
gaaggaggca gcggugagau ca                                                22


<210> 1372
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1372
caggaggcag ugggcgagca gg                                                22


<210> 1373
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1373
ccugcucgcc cacugccucc ug                                                22


<210> 1374
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1374
ugcaagacgg auacugucau cu                                                22


<210> 1375
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1375
agaugacagu auccgucuug ca                                                22


<210> 1376
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1376
ugucagugac uccugccccu uggu                                              24


<210> 1377
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1377
accaaggggc aggagucacu gaca                                              24


<210> 1378
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1378
agggggcgca gucacugacg ug                                                22


<210> 1379
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1379
cacgucagug acugcgcccc cu                                                22


<210> 1380
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1380
ucaaaaugua gaggaagacc cca                                               23


<210> 1381
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1381
uggggucuuc cucuacauuu uga                                               23


<210> 1382
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1382
aauuuacucu gcaaucuucu cc                                                22


<210> 1383
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1383
ggagaagauu gcagaguaaa uu                                                22


<210> 1384
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1384
agaagauugc agaguaaguu cc                                                22


<210> 1385
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1385
ggaacuuacu cugcaaucuu cu                                                22


<210> 1386
<211> 26
<212> RNA
<213> Homo sapiens

<400> 1386
cacaggacug acuccucacc ccagug                                            26


<210> 1387
<211> 26
<212> RNA
<213> Homo sapiens

<400> 1387
cacuggggug aggagucagu ccugug                                            26


<210> 1388
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1388
ucuggggaug aggacagugu gu                                                22


<210> 1389
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1389
acacacuguc cucaucccca ga                                                22


<210> 1390
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1390
augggugaug gguguggugu                                                   20


<210> 1391
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1391
acaccacacc caucacccau                                                   20


<210> 1392
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1392
uuggccacca caccuacccc uu                                                22


<210> 1393
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1393
aagggguagg ugugguggcc aa                                                22


<210> 1394
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1394
uguaguugua uuguauugcc ac                                                22


<210> 1395
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1395
guggcaauac aauacaacua ca                                                22


<210> 1396
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1396
uagcaauaca guacaaauau agu                                               23


<210> 1397
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1397
acuauauuug uacuguauug cua                                               23


<210> 1398
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1398
ucagucacau aucuaguguc ua                                                22


<210> 1399
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1399
uagacacuag auaugugacu ga                                                22


<210> 1400
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1400
gacacuaggc augugaguga uu                                                22


<210> 1401
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1401
aaucacucac augccuagug uc                                                22


<210> 1402
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1402
ucaaucacuu gguaauugcu gu                                                22


<210> 1403
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1403
acagcaauua ccaagugauu ga                                                22


<210> 1404
<211> 25
<212> RNA
<213> Homo sapiens

<400> 1404
agcggggagg aagugggcgc ugcuu                                             25


<210> 1405
<211> 25
<212> RNA
<213> Homo sapiens

<400> 1405
aagcagcgcc cacuuccucc ccgcu                                             25


<210> 1406
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1406
agcccgcccc agccgagguu cu                                                22


<210> 1407
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1407
agaaccucgg cuggggcggg cu                                                22


<210> 1408
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1408
gccccggcgc gggcggguuc ugg                                               23


<210> 1409
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1409
ccagaacccg cccgcgccgg ggc                                               23


<210> 1410
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1410
agcaaggcgg caucucucug au                                                22


<210> 1411
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1411
aucagagaga ugccgccuug cu                                                22


<210> 1412
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1412
agagaugccg ccuugcuccu u                                                 21


<210> 1413
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1413
aaggagcaag gcggcaucuc u                                                 21


<210> 1414
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1414
uugaagagga ggugcucugu agc                                               23


<210> 1415
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1415
gcuacagagc accuccucuu caa                                               23


<210> 1416
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1416
acaacaguga cuugcucucc aa                                                22


<210> 1417
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1417
uuggagagca agucacuguu gu                                                22


<210> 1418
<211> 18
<212> RNA
<213> Homo sapiens

<400> 1418
gggugagggc aggugguu                                                     18


<210> 1419
<211> 18
<212> RNA
<213> Homo sapiens

<400> 1419
aaccaccugc ccucaccc                                                     18


<210> 1420
<211> 18
<212> RNA
<213> Homo sapiens

<400> 1420
cgugucuucu ggcuugau                                                     18


<210> 1421
<211> 18
<212> RNA
<213> Homo sapiens

<400> 1421
aucaagccag aagacacg                                                     18


<210> 1422
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1422
ugcaucaggc cagaagacau gag                                               23


<210> 1423
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1423
cucaugucuu cuggccugau gca                                               23


<210> 1424
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1424
aaugagagac cuguacugua u                                                 21


<210> 1425
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1425
auacaguaca ggucucucau u                                                 21


<210> 1426
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1426
uccaguacag gucucucauu uc                                                22


<210> 1427
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1427
gaaaugagag accuguacug ga                                                22


<210> 1428
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1428
ugggauccag acagugggag aa                                                22


<210> 1429
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1429
uucucccacu gucuggaucc ca                                                22


<210> 1430
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1430
uucucccacu accaggcucc ca                                                22


<210> 1431
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1431
ugggagccug guagugggag aa                                                22


<210> 1432
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1432
ccaaccuagg uggucagagu ug                                                22


<210> 1433
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1433
caacucugac caccuagguu gg                                                22


<210> 1434
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1434
aacucugacc ccuuagguug au                                                22


<210> 1435
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1435
aucaaccuaa ggggucagag uu                                                22


<210> 1436
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1436
gugccaccuu aacugcagcc aau                                               23


<210> 1437
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1437
auuggcugca guuaaggugg cac                                               23


<210> 1438
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1438
aaguuggcug caguuaaggu gg                                                22


<210> 1439
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1439
ccaccuuaac ugcagccaac uu                                                22


<210> 1440
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1440
aagggggaag gaaacaugga ga                                                22


<210> 1441
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1441
ucuccauguu uccuuccccc uu                                                22


<210> 1442
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1442
uccauguuuc cuucccccuu cu                                                22


<210> 1443
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1443
agaaggggga aggaaacaug ga                                                22


<210> 1444
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1444
acacaugggu ggcuguggcc u                                                 21


<210> 1445
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1445
aggccacagc cacccaugug u                                                 21


<210> 1446
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1446
uaggccacag ccacccaugu gu                                                22


<210> 1447
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1447
acacaugggu ggcuguggcc ua                                                22


<210> 1448
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1448
agcuguaccu gaaaccaagc a                                                 21


<210> 1449
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1449
ugcuugguuu cagguacagc u                                                 21


<210> 1450
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1450
ucacaaaucu auaauaugca gg                                                22


<210> 1451
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1451
ccugcauauu auagauuugu ga                                                22


<210> 1452
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1452
ugcuuaaguu guaccaagua u                                                 21


<210> 1453
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1453
auacuuggua caacuuaagc a                                                 21


<210> 1454
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1454
ccuggcauau uugguauaac uu                                                22


<210> 1455
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1455
aaguuauacc aaauaugcca gg                                                22


<210> 1456
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1456
ugagggcucc aggugacggu gg                                                22


<210> 1457
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1457
ccaccgucac cuggagcccu ca                                                22


<210> 1458
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1458
accugccagc accucccugc ag                                                22


<210> 1459
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1459
cugcagggag gugcuggcag gu                                                22


<210> 1460
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1460
ggcaggaggg cugugccagg uug                                               23


<210> 1461
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1461
caaccuggca cagcccuccu gcc                                               23


<210> 1462
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1462
cccucucugg cuccucccca aa                                                22


<210> 1463
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1463
uuuggggagg agccagagag gg                                                22


<210> 1464
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1464
ugggggagcc augagauaag agca                                              24


<210> 1465
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1465
ugcucuuauc ucauggcucc ccca                                              24


<210> 1466
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1466
guaccuucug guucagcuag u                                                 21


<210> 1467
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1467
acuagcugaa ccagaaggua c                                                 21


<210> 1468
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1468
aacugaacca ggagugagcu ucg                                               23


<210> 1469
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1469
cgaagcucac uccugguuca guu                                               23


<210> 1470
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1470
uggggaaggc gucagugucg gg                                                22


<210> 1471
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1471
cccgacacug acgccuuccc ca                                                22


<210> 1472
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1472
agacccugca gccuucccac c                                                 21


<210> 1473
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1473
ggugggaagg cugcaggguc u                                                 21


<210> 1474
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1474
acccagguuc ccucuggccg ca                                                22


<210> 1475
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1475
ugcggccaga gggaaccugg gu                                                22


<210> 1476
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1476
agggccagag gagccuggag ugg                                               23


<210> 1477
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1477
ccacuccagg cuccucuggc ccu                                               23


<210> 1478
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1478
auagugggaa gcuggcagau uc                                                22


<210> 1479
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1479
gaaucugcca gcuucccacu au                                                22


<210> 1480
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1480
aucugccagc uuccacagug g                                                 21


<210> 1481
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1481
ccacugugga agcuggcaga u                                                 21


<210> 1482
<211> 25
<212> RNA
<213> Homo sapiens

<400> 1482
caugcugacc ucccuccugc cccag                                             25


<210> 1483
<211> 25
<212> RNA
<213> Homo sapiens

<400> 1483
cuggggcagg agggagguca gcaug                                             25


<210> 1484
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1484
ugggagggga gaggcagcaa gca                                               23


<210> 1485
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1485
ugcuugcugc cucuccccuc cca                                               23


<210> 1486
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1486
ucauuuaucu guugggaagc ua                                                22


<210> 1487
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1487
uagcuuccca acagauaaau ga                                                22


<210> 1488
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1488
cuggcggagc ccauuccaug cca                                               23


<210> 1489
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1489
uggcauggaa ugggcuccgc cag                                               23


<210> 1490
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1490
cacacaagug gcccccaaca cu                                                22


<210> 1491
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1491
aguguugggg gccacuugug ug                                                22


<210> 1492
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1492
ugcugggggc cacaugagug ug                                                22


<210> 1493
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1493
cacacucaug uggcccccag ca                                                22


<210> 1494
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1494
gcccugaccu guccuguucu g                                                 21


<210> 1495
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1495
cagaacagga caggucaggg c                                                 21


<210> 1496
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1496
uguagagcag ggagcaggaa gcu                                               23


<210> 1497
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1497
agcuuccugc ucccugcucu aca                                               23


<210> 1498
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1498
ccaccagguc uagcauuggg au                                                22


<210> 1499
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1499
aucccaaugc uagaccuggu gg                                                22


<210> 1500
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1500
aaucccaaug cuagacccgg ug                                                22


<210> 1501
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1501
caccgggucu agcauuggga uu                                                22


<210> 1502
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1502
gcugcgggcu gcggucaggg cg                                                22


<210> 1503
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1503
cgcccugacc gcagcccgca gc                                                22


<210> 1504
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1504
aaaggugcuc aaauuagaca u                                                 21


<210> 1505
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1505
augucuaauu ugagcaccuu u                                                 21


<210> 1506
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1506
ccuaauuuga acaccuucgg ua                                                22


<210> 1507
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1507
uaccgaaggu guucaaauua gg                                                22


<210> 1508
<211> 19
<212> RNA
<213> Homo sapiens

<400> 1508
aggcagguua ucugggcug                                                    19


<210> 1509
<211> 19
<212> RNA
<213> Homo sapiens

<400> 1509
cagcccagau aaccugccu                                                    19


<210> 1510
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1510
augcgaggau gcugacagug                                                   20


<210> 1511
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1511
cacugucagc auccucgcau                                                   20


<210> 1512
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1512
ugaaacugga gcgccuggag ga                                                22


<210> 1513
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1513
uccuccaggc gcuccaguuu ca                                                22


<210> 1514
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1514
accagcgcgu uuucaguuuc au                                                22


<210> 1515
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1515
augaaacuga aaacgcgcug gu                                                22


<210> 1516
<211> 25
<212> RNA
<213> Homo sapiens

<400> 1516
aagggaggag gagcggaggg gcccu                                             25


<210> 1517
<211> 25
<212> RNA
<213> Homo sapiens

<400> 1517
agggccccuc cgcuccuccu cccuu                                             25


<210> 1518
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1518
gcccgagagg auccgucccu gc                                                22


<210> 1519
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1519
gcagggacgg auccucucgg gc                                                22


<210> 1520
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1520
aggacugauc cucucgggca gg                                                22


<210> 1521
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1521
ccugcccgag aggaucaguc cu                                                22


<210> 1522
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1522
ucaggcaaag ggauauuuac aga                                               23


<210> 1523
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1523
ucuguaaaua ucccuuugcc uga                                               23


<210> 1524
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1524
uuucugucuu uucuggucca g                                                 21


<210> 1525
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1525
cuggaccaga aaagacagaa a                                                 21


<210> 1526
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1526
uggccggaug ggacaggagg cau                                               23


<210> 1527
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1527
augccuccug ucccauccgg cca                                               23


<210> 1528
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1528
ucuaaagacu agacuucgcu aug                                               23


<210> 1529
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1529
cauagcgaag ucuagucuuu aga                                               23


<210> 1530
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1530
uggcccggcg acgucucacg guc                                               23


<210> 1531
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1531
gaccgugaga cgucgccggg cca                                               23


<210> 1532
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1532
ugaguggggc ucccgggacg gcg                                               23


<210> 1533
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1533
cgccgucccg ggagccccac uca                                               23


<210> 1534
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1534
agcggugcuc cugcgggccg a                                                 21


<210> 1535
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1535
ucggcccgca ggagcaccgc u                                                 21


<210> 1536
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1536
ccggucccag gagaaccugc aga                                               23


<210> 1537
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1537
ucugcagguu cuccugggac cgg                                               23


<210> 1538
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1538
aaggcccggg cuuuccuccc ag                                                22


<210> 1539
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1539
cugggaggaa agcccgggcc uu                                                22


<210> 1540
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1540
agggaaggag gcuuggucuu ag                                                22


<210> 1541
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1541
cuaagaccaa gccuccuucc cu                                                22


<210> 1542
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1542
gagguuuggg gaggauuugc u                                                 21


<210> 1543
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1543
agcaaauccu ccccaaaccu c                                                 21


<210> 1544
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1544
cgccccuccu gcccccacag                                                   20


<210> 1545
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1545
cugugggggc aggaggggcg                                                   20


<210> 1546
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1546
ugcggggaca ggccagggca uc                                                22


<210> 1547
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1547
gaugcccugg ccuguccccg ca                                                22


<210> 1548
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1548
ccugacccac ccccucccgc ag                                                22


<210> 1549
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1549
cugcgggagg ggguggguca gg                                                22


<210> 1550
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1550
cucgggcgga ggugguugag ug                                                22


<210> 1551
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1551
cacucaacca ccuccgcccg ag                                                22


<210> 1552
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1552
agaggacccg uagcugcuag aagg                                              24


<210> 1553
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1553
ccuucuagca gcuacggguc cucu                                              24


<210> 1554
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1554
uuguggaucu caaggaugug cu                                                22


<210> 1555
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1555
agcacauccu ugagauccac aa                                                22


<210> 1556
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1556
uucucuuucu uuagccuugu gu                                                22


<210> 1557
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1557
acacaaggcu aaagaaagag aa                                                22


<210> 1558
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1558
caaggccaaa ggaagagaac ag                                                22


<210> 1559
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1559
cuguucucuu ccuuuggccu ug                                                22


<210> 1560
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1560
augcggaccu ggguuagcgg agu                                               23


<210> 1561
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1561
acuccgcuaa cccagguccg cau                                               23


<210> 1562
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1562
agccaggcuc ugaagggaaa gu                                                22


<210> 1563
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1563
acuuucccuu cagagccugg cu                                                22


<210> 1564
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1564
uuucccuuca gagccuggcu uu                                                22


<210> 1565
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1565
aaagccaggc ucugaaggga aa                                                22


<210> 1566
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1566
ccagagaugg uugccuuccu au                                                22


<210> 1567
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1567
auaggaaggc aaccaucucu gg                                                22


<210> 1568
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1568
cagggaggcg cucacucucu gcu                                               23


<210> 1569
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1569
agcagagagu gagcgccucc cug                                               23


<210> 1570
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1570
caugacguca cagaggcuuc gc                                                22


<210> 1571
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1571
gcgaagccuc ugugacguca ug                                                22


<210> 1572
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1572
aggccucugu gacgucacgg ugu                                               23


<210> 1573
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1573
acaccgugac gucacagagg ccu                                               23


<210> 1574
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1574
ugccccaccu gcugaccacc cuc                                               23


<210> 1575
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1575
gagggugguc agcagguggg gca                                               23


<210> 1576
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1576
gugaguggga gccggugggg cug                                               23


<210> 1577
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1577
cagccccacc ggcucccacu cac                                               23


<210> 1578
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1578
uaggacuaga uguuggaauu a                                                 21


<210> 1579
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1579
uaauuccaac aucuaguccu a                                                 21


<210> 1580
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1580
aaauucaugu ucaaucuaaa cc                                                22


<210> 1581
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1581
gguuuagauu gaacaugaau uu                                                22


<210> 1582
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1582
uuuagauuga acaugaaguu ag                                                22


<210> 1583
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1583
cuaacuucau guucaaucua aa                                                22


<210> 1584
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1584
gagggcaugc gcacuuuguc c                                                 21


<210> 1585
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1585
ggacaaagug cgcaugcccu c                                                 21


<210> 1586
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1586
acaaggugug caugccugac c                                                 21


<210> 1587
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1587
ggucaggcau gcacaccuug u                                                 21


<210> 1588
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1588
cuucugauca agauuugugg ug                                                22


<210> 1589
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1589
caccacaaau cuugaucaga ag                                                22


<210> 1590
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1590
ccaaaucuug aucagaagcc u                                                 21


<210> 1591
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1591
aggcuucuga ucaagauuug g                                                 21


<210> 1592
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1592
aggcaggggc uggugcuggg cggg                                              24


<210> 1593
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1593
cccgcccagc accagccccu gccu                                              24


<210> 1594
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1594
cgccugccca gcccuccugc u                                                 21


<210> 1595
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1595
agcaggaggg cugggcaggc g                                                 21


<210> 1596
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1596
uuaacuccuu ucacacccau gg                                                22


<210> 1597
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1597
ccaugggugu gaaaggaguu aa                                                22


<210> 1598
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1598
uggaugugga aggaguuauc u                                                 21


<210> 1599
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1599
agauaacucc uuccacaucc a                                                 21


<210> 1600
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1600
ugagugauug auagcuaugu uc                                                22


<210> 1601
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1601
gaacauagcu aucaaucacu ca                                                22


<210> 1602
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1602
auagcaauug cucuuuugga a                                                 21


<210> 1603
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1603
uuccaaaaga gcaauugcua u                                                 21


<210> 1604
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1604
ucugaaagag caguuggugu u                                                 21


<210> 1605
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1605
aacaccaacu gcucuuucag a                                                 21


<210> 1606
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1606
cgcgggcgcu ccuggccgcc gcc                                               23


<210> 1607
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1607
ggcggcggcc aggagcgccc gcg                                               23


<210> 1608
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1608
ccaggagauc cagagagaau                                                   20


<210> 1609
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1609
auucucucug gaucuccugg                                                   20


<210> 1610
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1610
auucucucug gaucccaugg au                                                22


<210> 1611
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1611
auccauggga uccagagaga au                                                22


<210> 1612
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1612
ucugccaucc ucccuccccu ac                                                22


<210> 1613
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1613
guaggggagg gaggauggca ga                                                22


<210> 1614
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1614
ggugggaugg agagaaggua ugag                                              24


<210> 1615
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1615
cucauaccuu cucuccaucc cacc                                              24


<210> 1616
<211> 18
<212> RNA
<213> Homo sapiens

<400> 1616
ugagaugaca cuguagcu                                                     18


<210> 1617
<211> 18
<212> RNA
<213> Homo sapiens

<400> 1617
agcuacagug ucaucuca                                                     18


<210> 1618
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1618
agcagacuug accuacaauu a                                                 21


<210> 1619
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1619
uaauuguagg ucaagucugc u                                                 21


<210> 1620
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1620
cagaacagga gcauagaaag gc                                                22


<210> 1621
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1621
gccuuucuau gcuccuguuc ug                                                22


<210> 1622
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1622
uuaauuuuuu guuucgguca cu                                                22


<210> 1623
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1623
agugaccgaa acaaaaaauu aa                                                22


<210> 1624
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1624
cuugccaucc ugguccacug cau                                               23


<210> 1625
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1625
augcagugga ccaggauggc aag                                               23


<210> 1626
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1626
guggaccagg auggcaaggg cu                                                22


<210> 1627
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1627
agcccuugcc auccuggucc ac                                                22


<210> 1628
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1628
auaccucauc uagaaugcug ua                                                22


<210> 1629
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1629
uacagcauuc uagaugaggu au                                                22


<210> 1630
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1630
uucuagauga gagauauaua ua                                                22


<210> 1631
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1631
uauauauauc ucucaucuag aa                                                22


<210> 1632
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1632
ucuucuuccu uugcagaguu ga                                                22


<210> 1633
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1633
ucaacucugc aaaggaagaa ga                                                22


<210> 1634
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1634
aauucuguaa aggaagaaga gg                                                22


<210> 1635
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1635
ccucuucuuc cuuuacagaa uu                                                22


<210> 1636
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1636
uaggagggaa uaguaaaagc ag                                                22


<210> 1637
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1637
cugcuuuuac uauucccucc ua                                                22


<210> 1638
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1638
acccuugagc cugaucccua gc                                                22


<210> 1639
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1639
gcuagggauc aggcucaagg gu                                                22


<210> 1640
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1640
aauguuggaa uccucgcuag ag                                                22


<210> 1641
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1641
cucuagcgag gauuccaaca uu                                                22


<210> 1642
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1642
uagcggggau uccaauauug g                                                 21


<210> 1643
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1643
ccaauauugg aauccccgcu a                                                 21


<210> 1644
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1644
ugauugucuu cauaucuaga ac                                                22


<210> 1645
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1645
guucuagaua ugaagacaau ca                                                22


<210> 1646
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1646
uucuggauau gaagacaauc aa                                                22


<210> 1647
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1647
uugauugucu ucauauccag aa                                                22


<210> 1648
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1648
ccccgguguu ggggcgcguc ugc                                               23


<210> 1649
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1649
gcagacgcgc cccaacaccg ggg                                               23


<210> 1650
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1650
ggcgcgccca gcucccgggc u                                                 21


<210> 1651
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1651
agcccgggag cugggcgcgc c                                                 21


<210> 1652
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1652
ugaggagaug cugggacuga                                                   20


<210> 1653
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1653
ucagucccag caucuccuca                                                   20


<210> 1654
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1654
agagucggcg acgccgccag c                                                 21


<210> 1655
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1655
gcuggcggcg ucgccgacuc u                                                 21


<210> 1656
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1656
ugaagccagc ucuggucugg gc                                                22


<210> 1657
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1657
gcccagacca gagcuggcuu ca                                                22


<210> 1658
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1658
ugagaccagg acuggaugca cc                                                22


<210> 1659
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1659
ggugcaucca guccuggucu ca                                                22


<210> 1660
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1660
gaugcgccgc ccacugcccc gcgc                                              24


<210> 1661
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1661
gcgcggggca gugggcggcg cauc                                              24


<210> 1662
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1662
gcgggggugg cggcggcauc cc                                                22


<210> 1663
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1663
gggaugccgc cgccaccccc gc                                                22


<210> 1664
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1664
uuacggacca gcuaagggag gc                                                22


<210> 1665
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1665
gccucccuua gcugguccgu aa                                                22


<210> 1666
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1666
cacacauagc agguguauau a                                                 21


<210> 1667
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1667
uauauacacc ugcuaugugu g                                                 21


<210> 1668
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1668
guauacaccu gauaugugua ug                                                22


<210> 1669
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1669
cauacacaua ucagguguau ac                                                22


<210> 1670
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1670
ugaaugguaa agcgauguca ca                                                22


<210> 1671
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1671
ugugacaucg cuuuaccauu ca                                                22


<210> 1672
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1672
aucgcuuuac cauucauguu                                                   20


<210> 1673
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1673
aacaugaaug guaaagcgau                                                   20


<210> 1674
<211> 18
<212> RNA
<213> Homo sapiens

<400> 1674
uggauaugau gacugaaa                                                     18


<210> 1675
<211> 18
<212> RNA
<213> Homo sapiens

<400> 1675
uuucagucau cauaucca                                                     18


<210> 1676
<211> 18
<212> RNA
<213> Homo sapiens

<400> 1676
cggugagcgc ucgcuggc                                                     18


<210> 1677
<211> 18
<212> RNA
<213> Homo sapiens

<400> 1677
gccagcgagc gcucaccg                                                     18


<210> 1678
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1678
ucugcacugu gaguuggcug gcu                                               23


<210> 1679
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1679
agccagccaa cucacagugc aga                                               23


<210> 1680
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1680
acauccugcu ccacagggca gagg                                              24


<210> 1681
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1681
ccucugcccu guggagcagg augu                                              24


<210> 1682
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1682
ucuggcuauc ucacgagacu gu                                                22


<210> 1683
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1683
acagucucgu gagauagcca ga                                                22


<210> 1684
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1684
auauuauuag ccacuucugg au                                                22


<210> 1685
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1685
auccagaagu ggcuaauaau au                                                22


<210> 1686
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1686
agaaguggcu aauaauauug a                                                 21


<210> 1687
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1687
ucaauauuau uagccacuuc u                                                 21


<210> 1688
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1688
uaaaguggca gaguauagac ac                                                22


<210> 1689
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1689
gugucuauac ucugccacuu ua                                                22


<210> 1690
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1690
ugucuauacu cugucacuuu ac                                                22


<210> 1691
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1691
guaaagugac agaguauaga ca                                                22


<210> 1692
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1692
ucucaguaag uggcacucug u                                                 21


<210> 1693
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1693
acagagugcc acuuacugag a                                                 21


<210> 1694
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1694
gacagagugc cacuuacuga a                                                 21


<210> 1695
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1695
uucaguaagu ggcacucugu c                                                 21


<210> 1696
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1696
aacucacgaa guauaccgaa gu                                                22


<210> 1697
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1697
acuucgguau acuucgugag uu                                                22


<210> 1698
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1698
uucgguauac uuugugaauu gg                                                22


<210> 1699
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1699
ccaauucaca aaguauaccg aa                                                22


<210> 1700
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1700
acuggcaugc ugcauuuaua ua                                                22


<210> 1701
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1701
uauauaaaug cagcaugcca gu                                                22


<210> 1702
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1702
aucuaaaugc agcaugccag uc                                                22


<210> 1703
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1703
gacuggcaug cugcauuuag au                                                22


<210> 1704
<211> 19
<212> RNA
<213> Homo sapiens

<400> 1704
cauccguccg ucuguccac                                                    19


<210> 1705
<211> 19
<212> RNA
<213> Homo sapiens

<400> 1705
guggacagac ggacggaug                                                    19


<210> 1706
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1706
aguggaccga ggaaggaagg a                                                 21


<210> 1707
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1707
uccuuccuuc cucgguccac u                                                 21


<210> 1708
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1708
uacacaagaa aaccaaggcu ca                                                22


<210> 1709
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1709
ugagccuugg uuuucuugug ua                                                22


<210> 1710
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1710
uaacauaaua guguggauug a                                                 21


<210> 1711
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1711
ucaauccaca cuauuauguu a                                                 21


<210> 1712
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1712
ugcuuaaccu ugcccucgaa a                                                 21


<210> 1713
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1713
uuucgagggc aagguuaagc a                                                 21


<210> 1714
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1714
uuggacggua agguuaagca a                                                 21


<210> 1715
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1715
uugcuuaacc uuaccgucca a                                                 21


<210> 1716
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1716
aaaagcauca ggaaguaccc a                                                 21


<210> 1717
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1717
uggguacuuc cugaugcuuu u                                                 21


<210> 1718
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1718
gcaggacagg cagaagugga u                                                 21


<210> 1719
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1719
auccacuucu gccuguccug c                                                 21


<210> 1720
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1720
cagggcuggc agugacaugg gu                                                22


<210> 1721
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1721
acccauguca cugccagccc ug                                                22


<210> 1722
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1722
auuucccugc cauucccuug gc                                                22


<210> 1723
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1723
gccaagggaa uggcagggaa au                                                22


<210> 1724
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1724
uggcggcggu aguuaugggc uu                                                22


<210> 1725
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1725
aagcccauaa cuaccgccgc ca                                                22


<210> 1726
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1726
gcucccucua gggucgcucg ga                                                22


<210> 1727
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1727
uccgagcgac ccuagaggga gc                                                22


<210> 1728
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1728
ugggaacuua guagagguuu aa                                                22


<210> 1729
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1729
uuaaaccucu acuaaguucc ca                                                22


<210> 1730
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1730
uggggcuagu gaugcaggac g                                                 21


<210> 1731
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1731
cguccugcau cacuagcccc a                                                 21


<210> 1732
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1732
gcugacagca gggcuggccg cu                                                22


<210> 1733
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1733
agcggccagc ccugcuguca gc                                                22


<210> 1734
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1734
auuggacugc ugauggcccg u                                                 21


<210> 1735
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1735
acgggccauc agcaguccaa u                                                 21


<210> 1736
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1736
aggccaucag caguccaaug aa                                                22


<210> 1737
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1737
uucauuggac ugcugauggc cu                                                22


<210> 1738
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1738
uuggacagaa aacacgcagg aa                                                22


<210> 1739
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1739
uuccugcgug uuuucugucc aa                                                22


<210> 1740
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1740
ccugcguguu uucuguccaa                                                   20


<210> 1741
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1741
uuggacagaa aacacgcagg                                                   20


<210> 1742
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1742
ugagacaggc uuaugcugcu au                                                22


<210> 1743
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1743
auagcagcau aagccugucu ca                                                22


<210> 1744
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1744
auagcagcau gaaccugucu ca                                                22


<210> 1745
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1745
ugagacaggu ucaugcugcu au                                                22


<210> 1746
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1746
gagacagguu caugcugcua                                                   20


<210> 1747
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1747
uagcagcaug aaccugucuc                                                   20


<210> 1748
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1748
auagcagcau aagccugucu c                                                 21


<210> 1749
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1749
gagacaggcu uaugcugcua u                                                 21


<210> 1750
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1750
uguguggauc cuggaggagg ca                                                22


<210> 1751
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1751
ugccuccucc aggauccaca ca                                                22


<210> 1752
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1752
agacaucaag aucaguccca aa                                                22


<210> 1753
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1753
uuugggacug aucuugaugu cu                                                22


<210> 1754
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1754
uuugggacug aucuugaugu cu                                                22


<210> 1755
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1755
agacaucaag aucaguccca aa                                                22


<210> 1756
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1756
aaggaaccag aaaaugagaa gu                                                22


<210> 1757
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1757
acuucucauu uucugguucc uu                                                22


<210> 1758
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1758
ucuggccuug acuugacucu uu                                                22


<210> 1759
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1759
aaagagucaa gucaaggcca ga                                                22


<210> 1760
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1760
ucaaggccag aggucccaca gca                                               23


<210> 1761
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1761
ugcuguggga ccucuggccu uga                                               23


<210> 1762
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1762
acuccaguuu uaguucucuu g                                                 21


<210> 1763
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1763
caagagaacu aaaacuggag u                                                 21


<210> 1764
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1764
aagagaacug aaaguggagc cu                                                22


<210> 1765
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1765
aggcuccacu uucaguucuc uu                                                22


<210> 1766
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1766
uaaggggugu auggcagaug ca                                                22


<210> 1767
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1767
ugcaucugcc auacaccccu ua                                                22


<210> 1768
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1768
uuucagauaa caguauuaca u                                                 21


<210> 1769
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1769
auguaauacu guuaucugaa a                                                 21


<210> 1770
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1770
aagcaauacu guuaccugaa au                                                22


<210> 1771
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1771
auuucaggua acaguauugc uu                                                22


<210> 1772
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1772
uacuaacugc agauucaagu ga                                                22


<210> 1773
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1773
ucacuugaau cugcaguuag ua                                                22


<210> 1774
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1774
auugccuaac augugccaga a                                                 21


<210> 1775
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1775
uucuggcaca uguuaggcaa u                                                 21


<210> 1776
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1776
ucugguaugu aguagguaau aa                                                22


<210> 1777
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1777
uuauuaccua cuacauacca ga                                                22


<210> 1778
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1778
aguugccuuu uuguucccau gc                                                22


<210> 1779
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1779
gcaugggaac aaaaaggcaa cu                                                22


<210> 1780
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1780
auaggcacca aaaagcaaca a                                                 21


<210> 1781
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1781
uuguugcuuu uuggugccua u                                                 21


<210> 1782
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1782
ccugcaacuu ugccugauca ga                                                22


<210> 1783
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1783
ucugaucagg caaaguugca gg                                                22


<210> 1784
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1784
ugaucaggca aaauugcaga cu                                                22


<210> 1785
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1785
agucugcaau uuugccugau ca                                                22


<210> 1786
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1786
uuguggcugg ucaugaggcu aa                                                22


<210> 1787
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1787
uuagccucau gaccagccac aa                                                22


<210> 1788
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1788
uuagucucau gaucagacac a                                                 21


<210> 1789
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1789
ugugucugau caugagacua a                                                 21


<210> 1790
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1790
aaagauagac aauuggcuaa au                                                22


<210> 1791
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1791
auuuagccaa uugucuaucu uu                                                22


<210> 1792
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1792
uuagccaauu guccaucuuu ag                                                22


<210> 1793
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1793
cuaaagaugg acaauuggcu aa                                                22


<210> 1794
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1794
ucugugagac caaagaacua cu                                                22


<210> 1795
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1795
aguaguucuu uggucucaca ga                                                22


<210> 1796
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1796
uuguucuuug gucuuucagc ca                                                22


<210> 1797
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1797
uggcugaaag accaaagaac aa                                                22


<210> 1798
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1798
cgggcugucc ggaggggucg gcu                                               23


<210> 1799
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1799
agccgacccc uccggacagc ccg                                               23


<210> 1800
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1800
ucuguauucu ccuuugccug cag                                               23


<210> 1801
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1801
cugcaggcaa aggagaauac aga                                               23


<210> 1802
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1802
uacauggaug gaaaccuuca agc                                               23


<210> 1803
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1803
gcuugaaggu uuccauccau gua                                               23


<210> 1804
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1804
uauggagguu cuagaccaug uu                                                22


<210> 1805
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1805
aacauggucu agaaccucca ua                                                22


<210> 1806
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1806
gggaccaucc ugccugcugu gg                                                22


<210> 1807
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1807
ccacagcagg caggaugguc cc                                                22


<210> 1808
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1808
ucagcaggca ggcuggugca gc                                                22


<210> 1809
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1809
gcugcaccag ccugccugcu ga                                                22


<210> 1810
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1810
ucaccugacc ucccaugccu gu                                                22


<210> 1811
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1811
acaggcaugg gaggucaggu ga                                                22


<210> 1812
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1812
caggcacggg agcucaggug ag                                                22


<210> 1813
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1813
cucaccugag cucccgugcc ug                                                22


<210> 1814
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1814
ugaguguugu cuacgagggc a                                                 21


<210> 1815
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1815
ugcccucgua gacaacacuc a                                                 21


<210> 1816
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1816
acugacagga gagcauuuug a                                                 21


<210> 1817
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1817
ucaaaaugcu cuccugucag u                                                 21


<210> 1818
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1818
ugaccuggga cucggacagc ug                                                22


<210> 1819
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1819
cagcuguccg agucccaggu ca                                                22


<210> 1820
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1820
ucucaggagu aaagacagag uu                                                22


<210> 1821
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1821
aacucugucu uuacuccuga ga                                                22


<210> 1822
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1822
aacucugucu ucacucauga gu                                                22


<210> 1823
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1823
acucaugagu gaagacagag uu                                                22


<210> 1824
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1824
uggggcggag cuuccggagg cc                                                22


<210> 1825
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1825
ggccuccgga agcuccgccc ca                                                22


<210> 1826
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1826
caaucagcaa guauacugcc cu                                                22


<210> 1827
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1827
agggcaguau acuugcugau ug                                                22


<210> 1828
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1828
uggcaguguc uuagcugguu gu                                                22


<210> 1829
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1829
acaaccagcu aagacacugc ca                                                22


<210> 1830
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1830
ccaauauugg cugugcugcu cc                                                22


<210> 1831
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1831
ggagcagcac agccaauauu gg                                                22


<210> 1832
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1832
uagcagcaca gaaauauugg c                                                 21


<210> 1833
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1833
gccaauauuu cugugcugcu a                                                 21


<210> 1834
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1834
uaauuuuaug uauaagcuag u                                                 21


<210> 1835
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1835
acuagcuuau acauaaaauu a                                                 21


<210> 1836
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1836
gagcuuauuc auaaaagugc ag                                                22


<210> 1837
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1837
cugcacuuuu augaauaagc uc                                                22


<210> 1838
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1838
aagacgggag gaaagaaggg ag                                                22


<210> 1839
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1839
cucccuucuu uccucccguc uu                                                22


<210> 1840
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1840
cagugguuuu acccuauggu ag                                                22


<210> 1841
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1841
cuaccauagg guaaaaccac ug                                                22


<210> 1842
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1842
auucuaauuu cuccacgucu uu                                                22


<210> 1843
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1843
aaagacgugg agaaauuaga au                                                22


<210> 1844
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1844
aaccagcacc ccaacuuugg ac                                                22


<210> 1845
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1845
guccaaaguu ggggugcugg uu                                                22


<210> 1846
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1846
aaagacauag gauagaguca ccuc                                              24


<210> 1847
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1847
gaggugacuc uauccuaugu cuuu                                              24


<210> 1848
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1848
uaacugguug aacaacugaa cc                                                22


<210> 1849
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1849
gguucaguug uucaaccagu ua                                                22


<210> 1850
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1850
cgugccaccc uuuuccccag                                                   20


<210> 1851
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1851
cuggggaaaa ggguggcacg                                                   20


<210> 1852
<211> 17
<212> RNA
<213> Homo sapiens

<400> 1852
guggggccag gcggugg                                                      17


<210> 1853
<211> 17
<212> RNA
<213> Homo sapiens

<400> 1853
ccaccgccug gccccac                                                      17


<210> 1854
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1854
aaaagcuggg uugagagggc aa                                                22


<210> 1855
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1855
uugcccucuc aacccagcuu uu                                                22


<210> 1856
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1856
gguccagagg ggagauaggu uc                                                22


<210> 1857
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1857
gaaccuaucu ccccucugga cc                                                22


<210> 1858
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1858
uagccuucag aucuuggugu uuu                                               23


<210> 1859
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1859
aaaacaccaa gaucugaagg cua                                               23


<210> 1860
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1860
ccacuuggau cugaaggcug ccc                                               23


<210> 1861
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1861
gggcagccuu cagauccaag ugg                                               23


<210> 1862
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1862
ugugcgcagg gagaccucuc cc                                                22


<210> 1863
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1863
gggagagguc ucccugcgca ca                                                22


<210> 1864
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1864
ugucuacuac uggagacacu gg                                                22


<210> 1865
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1865
ccagugucuc caguaguaga ca                                                22


<210> 1866
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1866
aaggcagggc ccccgcuccc c                                                 21


<210> 1867
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1867
ggggagcggg ggcccugccu u                                                 21


<210> 1868
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1868
cugacuguug ccguccucca g                                                 21


<210> 1869
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1869
cuggaggacg gcaacaguca g                                                 21


<210> 1870
<211> 25
<212> RNA
<213> Homo sapiens

<400> 1870
aaaaaccaca auuacuuuug cacca                                             25


<210> 1871
<211> 25
<212> RNA
<213> Homo sapiens

<400> 1871
uggugcaaaa guaauugugg uuuuu                                             25


<210> 1872
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1872
caaaaaccgc aauuacuuuu gca                                               23


<210> 1873
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1873
ugcaaaagua auugcgguuu uug                                               23


<210> 1874
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1874
augugccuga gggaguaaga ca                                                22


<210> 1875
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1875
ugucuuacuc ccucaggcac au                                                22


<210> 1876
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1876
ucuuacuccc ucaggcacug                                                   20


<210> 1877
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1877
cagugccuga gggaguaaga                                                   20


<210> 1878
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1878
agacacauuu ggagagggac cc                                                22


<210> 1879
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1879
gggucccucu ccaaaugugu cu                                                22


<210> 1880
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1880
gguucccucu ccaaaugugu cu                                                22


<210> 1881
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1881
agacacauuu ggagagggaa cc                                                22


<210> 1882
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1882
aaaauuucuu ucacuacuua g                                                 21


<210> 1883
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1883
cuaaguagug aaagaaauuu u                                                 21


<210> 1884
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1884
uuagugaagg cuauuuuaau u                                                 21


<210> 1885
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1885
aauuaaaaua gccuucacua a                                                 21


<210> 1886
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1886
acuguaaacg cuuucugaug                                                   20


<210> 1887
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1887
caucagaaag cguuuacagu                                                   20


<210> 1888
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1888
gcaugugaug aagcaaauca gu                                                22


<210> 1889
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1889
acugauuugc uucaucacau gc                                                22


<210> 1890
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1890
caaagugaug aguaauacug gcug                                              24


<210> 1891
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1891
cagccaguau uacucaucac uuug                                              24


<210> 1892
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1892
gaaucggaaa ggaggcgccg                                                   20


<210> 1893
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1893
cggcgccucc uuuccgauuc                                                   20


<210> 1894
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1894
uugugaagaa agaaauucuu a                                                 21


<210> 1895
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1895
uaagaauuuc uuucuucaca a                                                 21


<210> 1896
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1896
aggaggcauc uugagaaaug ga                                                22


<210> 1897
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1897
uccauuucuc aagaugccuc cu                                                22


<210> 1898
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1898
acaaaaaaaa aagcccaacc cuuc                                              24


<210> 1899
<211> 24
<212> RNA
<213> Homo sapiens

<400> 1899
gaaggguugg gcuuuuuuuu uugu                                              24


<210> 1900
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1900
uguuguacuu uuuuuuuugu uc                                                22


<210> 1901
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1901
gaacaaaaaa aaaaguacaa ca                                                22


<210> 1902
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1902
ucucucggcu ccucgcggcu c                                                 21


<210> 1903
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1903
gagccgcgag gagccgagag a                                                 21


<210> 1904
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1904
cgagggcauu ucaugaugca ggc                                               23


<210> 1905
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1905
gccugcauca ugaaaugccc ucg                                               23


<210> 1906
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1906
augaagugca cucaugauau gu                                                22


<210> 1907
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1907
acauaucaug agugcacuuc au                                                22


<210> 1908
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1908
ugucuacauu aaugaaaaga gc                                                22


<210> 1909
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1909
gcucuuuuca uuaauguaga ca                                                22


<210> 1910
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1910
ucacccugca ucccgcaccc ag                                                22


<210> 1911
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1911
cugggugcgg gaugcagggu ga                                                22


<210> 1912
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1912
gugggcuggg cugggcuggg cc                                                22


<210> 1913
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1913
ggcccagccc agcccagccc ac                                                22


<210> 1914
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1914
cgcgggucgg ggucugcagg                                                   20


<210> 1915
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1915
ccugcagacc ccgacccgcg                                                   20


<210> 1916
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1916
ucaccugagc ucccgugccu g                                                 21


<210> 1917
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1917
caggcacggg agcucaggug a                                                 21


<210> 1918
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1918
aggcauggga ggucagguga                                                   20


<210> 1919
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1919
ucaccugacc ucccaugccu                                                   20


<210> 1920
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1920
caucagcacc cuauguccuu ucu                                               23


<210> 1921
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1921
agaaaggaca uagggugcug aug                                               23


<210> 1922
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1922
aaagacauag uugcaagaug gg                                                22


<210> 1923
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1923
cccaucuugc aacuaugucu uu                                                22


<210> 1924
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1924
uuugugaccu gguccacuaa cc                                                22


<210> 1925
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1925
gguuagugga ccaggucaca aa                                                22


<210> 1926
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1926
gaugguugac cagagagcac ac                                                22


<210> 1927
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1927
gugugcucuc uggucaacca uc                                                22


<210> 1928
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1928
aaaagcuggg uugagagggu                                                   20


<210> 1929
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1929
acccucucaa cccagcuuuu                                                   20


<210> 1930
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1930
cacaagguau ugguauuacc u                                                 21


<210> 1931
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1931
agguaauacc aauaccuugu g                                                 21


<210> 1932
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1932
uaguaccagu accuuguguu ca                                                22


<210> 1933
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1933
ugaacacaag guacugguac ua                                                22


<210> 1934
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1934
aguauucugu accagggaag gu                                                22


<210> 1935
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1935
accuucccug guacagaaua cu                                                22


<210> 1936
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1936
uggcagugua uuguuagcug gu                                                22


<210> 1937
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1937
accagcuaac aauacacugc ca                                                22


<210> 1938
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1938
uauacaaggg caagcucucu gu                                                22


<210> 1939
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1939
acagagagcu ugcccuugua ua                                                22


<210> 1940
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1940
agcgagguug cccuuuguau au                                                22


<210> 1941
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1941
auauacaaag ggcaaccucg cu                                                22


<210> 1942
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1942
caaucacuaa cuccacugcc au                                                22


<210> 1943
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1943
auggcagugg aguuagugau ug                                                22


<210> 1944
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1944
uaggcagugu cauuagcuga uug                                               23


<210> 1945
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1945
caaucagcua augacacugc cua                                               23


<210> 1946
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1946
cagccacaac uacccugcca cu                                                22


<210> 1947
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1947
aguggcaggg uaguuguggc ug                                                22


<210> 1948
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1948
aggcagugua uuguuagcug gc                                                22


<210> 1949
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1949
gccagcuaac aauacacugc cu                                                22


<210> 1950
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1950
aaucacuaac cacacggcca gg                                                22


<210> 1951
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1951
ccuggccgug ugguuaguga uu                                                22


<210> 1952
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1952
aggcagugua guuagcugau ugc                                               23


<210> 1953
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1953
gcaaucagcu aacuacacug ccu                                               23


<210> 1954
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1954
guccgcucgg cgguggccca                                                   20


<210> 1955
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1955
ugggccaccg ccgagcggac                                                   20


<210> 1956
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1956
gaacgccugu ucuugccagg ugg                                               23


<210> 1957
<211> 23
<212> RNA
<213> Homo sapiens

<400> 1957
ccaccuggca agaacaggcg uuc                                               23


<210> 1958
<211> 19
<212> RNA
<213> Homo sapiens

<400> 1958
aagugugcag ggcacuggu                                                    19


<210> 1959
<211> 19
<212> RNA
<213> Homo sapiens

<400> 1959
accagugccc ugcacacuu                                                    19


<210> 1960
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1960
aggggugcua ucugugauug a                                                 21


<210> 1961
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1961
ucaaucacag auagcacccc u                                                 21


<210> 1962
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1962
cuuucaguca gauguuugcu gc                                                22


<210> 1963
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1963
gcagcaaaca ucugacugaa ag                                                22


<210> 1964
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1964
uguaaacauc cccgacugga ag                                                22


<210> 1965
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1965
cuuccagucg gggauguuua ca                                                22


<210> 1966
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1966
uguaaacauc cucgacugga ag                                                22


<210> 1967
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1967
cuuccagucg aggauguuua ca                                                22


<210> 1968
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1968
agaaguaauu gcgguuuugc ca                                                22


<210> 1969
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1969
uggcaaaacc gcaauuacuu cu                                                22


<210> 1970
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1970
caaaacuggc aauuacuuuu gc                                                22


<210> 1971
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1971
gcaaaaguaa uugccaguuu ug                                                22


<210> 1972
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1972
aaaaguaauu gcgaguuuua cc                                                22


<210> 1973
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1973
gguaaaacuc gcaauuacuu uu                                                22


<210> 1974
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1974
caagaaccuc aguugcuuuu gu                                                22


<210> 1975
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1975
acaaaagcaa cugagguucu ug                                                22


<210> 1976
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1976
caaaaaucuc aauuacuuuu gc                                                22


<210> 1977
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1977
gcaaaaguaa uugagauuuu ug                                                22


<210> 1978
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1978
caaaaaccac aguuucuuuu gc                                                22


<210> 1979
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1979
gcaaaagaaa cugugguuuu ug                                                22


<210> 1980
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1980
aaaaguaauu gugguuuuug cc                                                22


<210> 1981
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1981
ggcaaaaacc acaauuacuu uu                                                22


<210> 1982
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1982
ugacaacuau ggaugagcuc u                                                 21


<210> 1983
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1983
agagcucauc cauaguuguc a                                                 21


<210> 1984
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1984
aacaggugac ugguuagaca a                                                 21


<210> 1985
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1985
uugucuaacc agucaccugu u                                                 21


<210> 1986
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1986
aaaacgguga gauuuuguuu u                                                 21


<210> 1987
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1987
aaaacaaaau cucaccguuu u                                                 21


<210> 1988
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1988
gcuaguccug acucagccag u                                                 21


<210> 1989
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1989
acuggcugag ucaggacuag c                                                 21


<210> 1990
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1990
aggguaagcu gaaccucuga u                                                 21


<210> 1991
<211> 21
<212> RNA
<213> Homo sapiens

<400> 1991
aucagagguu cagcuuaccc u                                                 21


<210> 1992
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1992
auauuaccau uagcucaucu uu                                                22


<210> 1993
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1993
aaagaugagc uaaugguaau au                                                22


<210> 1994
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1994
gaugagcuca uuguaauaug ag                                                22


<210> 1995
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1995
cucauauuac aaugagcuca uc                                                22


<210> 1996
<211> 19
<212> RNA
<213> Homo sapiens

<400> 1996
agguugacau acguuuccc                                                    19


<210> 1997
<211> 19
<212> RNA
<213> Homo sapiens

<400> 1997
gggaaacgua ugucaaccu                                                    19


<210> 1998
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1998
auguauaaau guauacacac                                                   20


<210> 1999
<211> 20
<212> RNA
<213> Homo sapiens

<400> 1999
guguguauac auuuauacau                                                   20


<210> 2000
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2000
cugaagugau guguaacuga ucag                                              24


<210> 2001
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2001
cugaucaguu acacaucacu ucag                                              24


<210> 2002
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2002
aagaugugga aaaauuggaa uc                                                22


<210> 2003
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2003
gauuccaauu uuuccacauc uu                                                22


<210> 2004
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2004
uagauaaaau auugguaccu g                                                 21


<210> 2005
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2005
cagguaccaa uauuuuaucu a                                                 21


<210> 2006
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2006
cuucuugugc ucuaggauug u                                                 21


<210> 2007
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2007
acaauccuag agcacaagaa g                                                 21


<210> 2008
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2008
uaugcauugu auuuuuaggu cc                                                22


<210> 2009
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2009
ggaccuaaaa auacaaugca ua                                                22


<210> 2010
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2010
uuuccauagg ugaugaguca c                                                 21


<210> 2011
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2011
gugacucauc accuauggaa a                                                 21


<210> 2012
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2012
uuggccacaa uggguuagaa c                                                 21


<210> 2013
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2013
guucuaaccc auuguggcca a                                                 21


<210> 2014
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2014
ugugucacuc gaugaccacu gu                                                22


<210> 2015
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2015
acagugguca ucgagugaca ca                                                22


<210> 2016
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2016
acuuacagac aagagccuug cuc                                               23


<210> 2017
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2017
gagcaaggcu cuugucugua agu                                               23


<210> 2018
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2018
aggcugcgga auucaggac                                                    19


<210> 2019
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2019
guccugaauu ccgcagccu                                                    19


<210> 2020
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2020
uaaaucccau ggugccuucu ccu                                               23


<210> 2021
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2021
aggagaaggc accaugggau uua                                               23


<210> 2022
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2022
aaacuacuga aaaucaaaga u                                                 21


<210> 2023
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2023
aucuuugauu uucaguaguu u                                                 21


<210> 2024
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2024
guucaaaucc agaucuauaa c                                                 21


<210> 2025
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2025
guuauagauc uggauuugaa c                                                 21


<210> 2026
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2026
ccgguuccag ucccuggag                                                    19


<210> 2027
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2027
cuccagggac uggaaccgg                                                    19


<210> 2028
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2028
aggguguuuc ucucaucucu                                                   20


<210> 2029
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2029
agagaugaga gaaacacccu                                                   20


<210> 2030
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2030
gaccuggaca uguuugugcc cagu                                              24


<210> 2031
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2031
acugggcaca aacaugucca gguc                                              24


<210> 2032
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2032
auggagauag auauagaaau                                                   20


<210> 2033
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2033
auuucuauau cuaucuccau                                                   20


<210> 2034
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2034
agcugucuga aaaugucuu                                                    19


<210> 2035
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2035
aagacauuuu cagacagcu                                                    19


<210> 2036
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2036
agaccuggcc cagaccucag c                                                 21


<210> 2037
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2037
gcugaggucu gggccagguc u                                                 21


<210> 2038
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2038
acuugggcac ugaaacaaug ucc                                               23


<210> 2039
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2039
ggacauuguu ucagugccca agu                                               23


<210> 2040
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2040
acugggggcu uucgggcucu gcgu                                              24


<210> 2041
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2041
acgcagagcc cgaaagcccc cagu                                              24


<210> 2042
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2042
aucgcugcgg uugcgagcgc ugu                                               23


<210> 2043
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2043
acagcgcucg caaccgcagc gau                                               23


<210> 2044
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2044
gucccucucc aaaugugucu ug                                                22


<210> 2045
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2045
caagacacau uuggagaggg ac                                                22


<210> 2046
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2046
acuuguaugc uagcucaggu ag                                                22


<210> 2047
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2047
cuaccugagc uagcauacaa gu                                                22


<210> 2048
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2048
uuuaggauaa gcuugacuuu ug                                                22


<210> 2049
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2049
caaaagucaa gcuuauccua aa                                                22


<210> 2050
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2050
guguugaaac aaucucuacu g                                                 21


<210> 2051
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2051
caguagagau uguuucaaca c                                                 21


<210> 2052
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2052
uaugucugcu gaccaucacc uu                                                22


<210> 2053
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2053
aaggugaugg ucagcagaca ua                                                22


<210> 2054
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2054
ggggcugggg ccggggccga gc                                                22


<210> 2055
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2055
gcucggcccc ggccccagcc cc                                                22


<210> 2056
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2056
ugagguagua gguuguaugg uu                                                22


<210> 2057
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2057
aaccauacaa ccuacuaccu ca                                                22


<210> 2058
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2058
gugucuuuug cucugcaguc a                                                 21


<210> 2059
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2059
ugacugcaga gcaaaagaca c                                                 21


<210> 2060
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2060
ccccgggaac gucgagacug gagc                                              24


<210> 2061
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2061
gcuccagucu cgacguuccc gggg                                              24


<210> 2062
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2062
acccgucccg uucguccccg ga                                                22


<210> 2063
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2063
uccggggacg aacgggacgg gu                                                22


<210> 2064
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2064
augggugaau uuguagaagg au                                                22


<210> 2065
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2065
auccuucuac aaauucaccc au                                                22


<210> 2066
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2066
cuggacugag ccgugcuacu gg                                                22


<210> 2067
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2067
ccaguagcac ggcucagucc ag                                                22


<210> 2068
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2068
cuggacugag ccaugcuacu gg                                                22


<210> 2069
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2069
ccaguagcau ggcucagucc ag                                                22


<210> 2070
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2070
uacguagaua uauauguauu uu                                                22


<210> 2071
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2071
aaaauacaua uauaucuacg ua                                                22


<210> 2072
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2072
aaauauauau auauauguac guau                                              24


<210> 2073
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2073
gcucuuuuca uuaauguaga ca                                                22


<210> 2074
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2074
ugcuggauca gugguucgag uc                                                22


<210> 2075
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2075
gacucgaacc acugauccag ca                                                22


<210> 2076
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2076
uggauuuuug gaucaggga                                                    19


<210> 2077
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2077
ucccugaucc aaaaaucca                                                    19


<210> 2078
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2078
uuauaaagca augagacuga uu                                                22


<210> 2079
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2079
aaucagucuc auugcuuuau aa                                                22


<210> 2080
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2080
uagugcaaua uugcuuauag ggu                                               23


<210> 2081
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2081
acccuauaag caauauugca cua                                               23


<210> 2082
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2082
acccuaucaa uauugucucu gc                                                22


<210> 2083
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2083
gcagagacaa uauugauagg gu                                                22


<210> 2084
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2084
uaagugcuuc caugcuu                                                      17


<210> 2085
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2085
aagcauggaa gcacuua                                                      17


<210> 2086
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2086
ucggccugac cacccacccc ac                                                22


<210> 2087
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2087
gugggguggg uggucaggcc ga                                                22


<210> 2088
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2088
gggggggggg ggggggggcc g                                                 21


<210> 2089
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2089
cggccccccc cccccccccc c                                                 21


<210> 2090
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2090
cuauacgacc ugcugccuuu cu                                                22


<210> 2091
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2091
agaaaggcag caggucguau ag                                                22


<210> 2092
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2092
agagguagua gguugcauag uu                                                22


<210> 2093
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2093
aacuaugcaa ccuacuaccu cu                                                22


<210> 2094
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2094
ccgcacugug gguacuugcu gc                                                22


<210> 2095
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2095
gcagcaagua cccacagugc gg                                                22


<210> 2096
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2096
uaaagugcug acagugcaga u                                                 21


<210> 2097
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2097
aucugcacug ucagcacuuu a                                                 21


<210> 2098
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2098
aacuggauca auuauaggag ug                                                22


<210> 2099
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2099
cacuccuaua auugauccag uu                                                22


<210> 2100
<211> 26
<212> RNA
<213> Homo sapiens

<400> 2100
aaguaguugg uuuguaugag augguu                                            26


<210> 2101
<211> 26
<212> RNA
<213> Homo sapiens

<400> 2101
aaccaucuca uacaaaccaa cuacuu                                            26


<210> 2102
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2102
aagugaucua aaggccuaca u                                                 21


<210> 2103
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2103
auguaggccu uuagaucacu u                                                 21


<210> 2104
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2104
ucagaugauc uaaaggccua ua                                                22


<210> 2105
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2105
uauaggccuu uagaucaucu ga                                                22


<210> 2106
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2106
uaggccuuua gaucacuuaa a                                                 21


<210> 2107
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2107
uuuaagugau cuaaaggccu a                                                 21


<210> 2108
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2108
acucuagcug ccaaaggcgc u                                                 21


<210> 2109
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2109
agcgccuuug gcagcuagag u                                                 21


<210> 2110
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2110
agaaggaaau ugaauucauu ua                                                22


<210> 2111
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2111
uaaaugaauu caauuuccuu cu                                                22


<210> 2112
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2112
agagaagaag aucagccugc a                                                 21


<210> 2113
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2113
ugcaggcuga ucuucuucuc u                                                 21


<210> 2114
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2114
agccuggaag cuggagccug cagu                                              24


<210> 2115
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2115
acugcaggcu ccagcuucca ggcu                                              24


<210> 2116
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2116
aggaugagca aagaaaguag auu                                               23


<210> 2117
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2117
aaucuacuuu cuuugcucau ccu                                               23


<210> 2118
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2118
aaccacuuuc uuugcucauc ca                                                22


<210> 2119
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2119
uggaugagca aagaaagugg uu                                                22


<210> 2120
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2120
cggaugagca aagaaagugg uu                                                22


<210> 2121
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2121
aaccacuuuc uuugcucauc cg                                                22


<210> 2122
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2122
aggcauugac uucucacuag cu                                                22


<210> 2123
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2123
agcuagugag aagucaaugc cu                                                22


<210> 2124
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2124
agugaaugau ggguucugac c                                                 21


<210> 2125
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2125
ggucagaacc caucauucac u                                                 21


<210> 2126
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2126
aguuaggauu aggucgugga a                                                 21


<210> 2127
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2127
uuccacgacc uaauccuaac u                                                 21


<210> 2128
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2128
auggauaagg cuuuggcuu                                                    19


<210> 2129
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2129
aagccaaagc cuuauccau                                                    19


<210> 2130
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2130
augguacccu ggcauacuga gu                                                22


<210> 2131
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2131
acucaguaug ccaggguacc au                                                22


<210> 2132
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2132
caagucuuau uugagcaccu guu                                               23


<210> 2133
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2133
aacaggugcu caaauaagac uug                                               23


<210> 2134
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2134
caggaugugg ucaaguguug uu                                                22


<210> 2135
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2135
aacaacacuu gaccacaucc ug                                                22


<210> 2136
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2136
ccucagggcu guagaacagg gcu                                               23


<210> 2137
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2137
agcccuguuc uacagcccug agg                                               23


<210> 2138
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2138
ccuguugaag uguaaucccc a                                                 21


<210> 2139
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2139
uggggauuac acuucaacag g                                                 21


<210> 2140
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2140
cgggcguggu gguggggg                                                     18


<210> 2141
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2141
cccccaccac cacgcccg                                                     18


<210> 2142
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2142
cgggcguggu ggugggggug                                                   20


<210> 2143
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2143
cacccccacc accacgcccg                                                   20


<210> 2144
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2144
cuggagauau ggaagagcug ugu                                               23


<210> 2145
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2145
acacagcucu uccauaucuc cag                                               23


<210> 2146
<211> 26
<212> RNA
<213> Homo sapiens

<400> 2146
gaugaugaug gcagcaaauu cugaaa                                            26


<210> 2147
<211> 26
<212> RNA
<213> Homo sapiens

<400> 2147
uuucagaauu ugcugccauc aucauc                                            26


<210> 2148
<211> 25
<212> RNA
<213> Homo sapiens

<400> 2148
gggcgacaaa gcaagacucu uucuu                                             25


<210> 2149
<211> 25
<212> RNA
<213> Homo sapiens

<400> 2149
aagaaagagu cuugcuuugu cgccc                                             25


<210> 2150
<211> 25
<212> RNA
<213> Homo sapiens

<400> 2150
gaacccauga gguugaggcu gcagu                                             25


<210> 2151
<211> 25
<212> RNA
<213> Homo sapiens

<400> 2151
acugcagccu caaccucaug gguuc                                             25


<210> 2152
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2152
gugggggaga ggcuguc                                                      17


<210> 2153
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2153
gacagccucu cccccac                                                      17


<210> 2154
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2154
uaaagagccc uguggagaca                                                   20


<210> 2155
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2155
ugucuccaca gggcucuuua                                                   20


<210> 2156
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2156
uaguacugug cauaucaucu au                                                22


<210> 2157
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2157
auagaugaua ugcacaguac ua                                                22


<210> 2158
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2158
ucguuugccu uuuucugcuu                                                   20


<210> 2159
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2159
aagcagaaaa aggcaaacga                                                   20


<210> 2160
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2160
uggacugccc ugaucuggag a                                                 21


<210> 2161
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2161
ucuccagauc agggcagucc a                                                 21


<210> 2162
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2162
uggguggucu ggagauuugu gc                                                22


<210> 2163
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2163
gcacaaaucu ccagaccacc ca                                                22


<210> 2164
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2164
ugugagguug gcauuguugu cu                                                22


<210> 2165
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2165
agacaacaau gccaaccuca ca                                                22


<210> 2166
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2166
uucaaguaau ucaggug                                                      17


<210> 2167
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2167
caccugaauu acuugaa                                                      17


<210> 2168
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2168
uucuggaauu cugugugagg ga                                                22


<210> 2169
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2169
ucccucacac agaauuccag aa                                                22


<210> 2170
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2170
uuuucaacuc uaaugggaga ga                                                22


<210> 2171
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2171
ucucucccau uagaguugaa aa                                                22


<210> 2172
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2172
acguuggcuc ugguggug                                                     18


<210> 2173
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2173
caccaccaga gccaacgu                                                     18


<210> 2174
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2174
ccaccucccc ugcaaacguc ca                                                22


<210> 2175
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2175
uggacguuug caggggaggu gg                                                22


<210> 2176
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2176
acucggcgug gcgucggucg ug                                                22


<210> 2177
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2177
cacgaccgac gccacgccga gu                                                22


<210> 2178
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2178
ucgaccggac cucgaccggc u                                                 21


<210> 2179
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2179
agccggucga gguccggucg a                                                 21


<210> 2180
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2180
ugagaacuga auuccauagg cu                                                22


<210> 2181
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2181
agccuaugga auucaguucu ca                                                22


<210> 2182
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2182
aaucauacac gguugaccua uu                                                22


<210> 2183
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2183
aauaggucaa ccguguauga uu                                                22


<210> 2184
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2184
uagguuaucc guguugccuu cg                                                22


<210> 2185
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2185
cgaaggcaac acggauaacc ua                                                22


<210> 2186
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2186
ccaguccugu gccugccgcc u                                                 21


<210> 2187
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2187
aggcggcagg cacaggacug g                                                 21


<210> 2188
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2188
ucugcccccu ccgcugcugc ca                                                22


<210> 2189
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2189
uggcagcagc ggagggggca ga                                                22


<210> 2190
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2190
ggaggggucc cgcacuggga gg                                                22


<210> 2191
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2191
ccucccagug cgggaccccu cc                                                22


<210> 2192
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2192
cccugugccc ggcccacuuc ug                                                22


<210> 2193
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2193
cagaaguggg ccgggcacag gg                                                22


<210> 2194
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2194
ccccagggcg acgcggcggg                                                   20


<210> 2195
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2195
cccgccgcgu cgcccugggg                                                   20


<210> 2196
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2196
accuugccuu gcugcccggg cc                                                22


<210> 2197
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2197
ggcccgggca gcaaggcaag gu                                                22


<210> 2198
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2198
auuugugcuu ggcucuguca c                                                 21


<210> 2199
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2199
gugacagagc caagcacaaa u                                                 21


<210> 2200
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2200
auuguccuug cuguuuggag au                                                22


<210> 2201
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2201
aucuccaaac agcaaggaca au                                                22


<210> 2202
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2202
auccccagau acaauggaca a                                                 21


<210> 2203
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2203
uuguccauug uaucugggga u                                                 21


<210> 2204
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2204
cagugcaaua guauugucaa agc                                               23


<210> 2205
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2205
gcuuugacaa uacuauugca cug                                               23


<210> 2206
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2206
gcucugacuu uauugcacua cu                                                22


<210> 2207
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2207
aguagugcaa uaaagucaga gc                                                22


<210> 2208
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2208
uaagugcuuc cauguuuuag uag                                               23


<210> 2209
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2209
cuacuaaaac auggaagcac uua                                               23


<210> 2210
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2210
acuuuaacau ggaagugcuu uc                                                22


<210> 2211
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2211
gaaagcacuu ccauguuaaa gu                                                22


<210> 2212
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2212
uaagugcuuc cauguuucag ugg                                               23


<210> 2213
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2213
ccacugaaac auggaagcac uua                                               23


<210> 2214
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2214
uuuaacaugg ggguaccugc ug                                                22


<210> 2215
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2215
cagcagguac ccccauguua aa                                                22


<210> 2216
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2216
uaagugcuuc cauguuugag ugu                                               23


<210> 2217
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2217
acacucaaac auggaagcac uua                                               23


<210> 2218
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2218
acuuuaacau ggaggcacuu gc                                                22


<210> 2219
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2219
gcaagugccu ccauguuaaa gu                                                22


<210> 2220
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2220
aauugcacuu uagcaauggu ga                                                22


<210> 2221
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2221
ucaccauugc uaaagugcaa uu                                                22


<210> 2222
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2222
acuguugcua auaugcaacu cu                                                22


<210> 2223
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2223
agaguugcau auuagcaaca gu                                                22


<210> 2224
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2224
agcucggucu gaggccccuc agu                                               23


<210> 2225
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2225
acugaggggc cucagaccga gcu                                               23


<210> 2226
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2226
aaaaacugag acuacuuuug ca                                                22


<210> 2227
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2227
ugcaaaagua gucucaguuu uu                                                22


<210> 2228
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2228
aaaaacugua auuacuuuu                                                    19


<210> 2229
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2229
aaaaguaauu acaguuuuu                                                    19


<210> 2230
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2230
aaaacuguaa uuacuuuugu ac                                                22


<210> 2231
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2231
guacaaaagu aauuacaguu uu                                                22


<210> 2232
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2232
ugcaaaagua auugcaguuu uug                                               23


<210> 2233
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2233
caaaaacugc aauuacuuuu gca                                               23


<210> 2234
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2234
caaaaaccgc aauuacuuuu gca                                               23


<210> 2235
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2235
ugcaaaagua auugcgguuu uug                                               23


<210> 2236
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2236
aaaaguaauc gcgguuuuug uc                                                22


<210> 2237
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2237
gacaaaaacc gcgauuacuu uu                                                22


<210> 2238
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2238
aaaaguacuu gcggauuuug cu                                                22


<210> 2239
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2239
agcaaaaucc gcaaguacuu uu                                                22


<210> 2240
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2240
aaaaguauuu gcggguuuug uc                                                22


<210> 2241
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2241
gacaaaaccc gcaaauacuu uu                                                22


<210> 2242
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2242
caaagguauu ugugguuuuu g                                                 21


<210> 2243
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2243
caaaaaccac aaauaccuuu g                                                 21


<210> 2244
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2244
ccaaaacugc aguuacuuuu gc                                                22


<210> 2245
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2245
gcaaaaguaa cugcaguuuu gg                                                22


<210> 2246
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2246
aaaaguaauu gcgguuuuug cc                                                22


<210> 2247
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2247
ggcaaaaacc gcaauuacuu uu                                                22


<210> 2248
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2248
uagcaaaaac ugcaguuacu uu                                                22


<210> 2249
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2249
aaaguaacug caguuuuugc ua                                                22


<210> 2250
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2250
ggagguuggg aagggcagag                                                   20


<210> 2251
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2251
cucugcccuu cccaaccucc                                                   20


<210> 2252
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2252
ugaggcgggg gggcgagc                                                     18


<210> 2253
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2253
gcucgccccc ccgccuca                                                     18


<210> 2254
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2254
agagaugaag cgggggggcg                                                   20


<210> 2255
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2255
cgcccccccg cuucaucucu                                                   20


<210> 2256
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2256
ggaggccggg guggggcggg gcgg                                              24


<210> 2257
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2257
ccgccccgcc ccaccccggc cucc                                              24


<210> 2258
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2258
ggggagcgag gggcggggc                                                    19


<210> 2259
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2259
gccccgcccc ucgcucccc                                                    19


<210> 2260
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2260
uauucauuua uccccagccu aca                                               23


<210> 2261
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2261
uguaggcugg ggauaaauga aua                                               23


<210> 2262
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2262
acuggcuagg gaaaaugauu ggau                                              24


<210> 2263
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2263
auccaaucau uuucccuagc cagu                                              24


<210> 2264
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2264
uucauuugcc ucccagccua ca                                                22


<210> 2265
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2265
uguaggcugg gaggcaaaug aa                                                22


<210> 2266
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2266
ugggcuaagg gagaugauug ggua                                              24


<210> 2267
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2267
uacccaauca ucucccuuag ccca                                              24


<210> 2268
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2268
acuccagccc cacagccuca gc                                                22


<210> 2269
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2269
gcugaggcug uggggcugga gu                                                22


<210> 2270
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2270
aggaggaauu ggugcugguc uu                                                22


<210> 2271
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2271
aagaccagca ccaauuccuc cu                                                22


<210> 2272
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2272
aggcagcggg guguagugga ua                                                22


<210> 2273
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2273
uauccacuac accccgcugc cu                                                22


<210> 2274
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2274
uccauuacac uacccugccu cu                                                22


<210> 2275
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2275
agaggcaggg uaguguaaug ga                                                22


<210> 2276
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2276
acugcugagc uagcacuucc cg                                                22


<210> 2277
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2277
cgggaagugc uagcucagca gu                                                22


<210> 2278
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2278
caaagugcug uucgugcagg uag                                               23


<210> 2279
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2279
cuaccugcac gaacagcacu uug                                               23


<210> 2280
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2280
cacccggcug ugugcacaug ugc                                               23


<210> 2281
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2281
gcacaugugc acacagccgg gug                                               23


<210> 2282
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2282
agcuucuuua cagugcugcc uug                                               23


<210> 2283
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2283
caaggcagca cuguaaagaa gcu                                               23


<210> 2284
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2284
agcagcauug uacagggcua uga                                               23


<210> 2285
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2285
ucauagcccu guacaaugcu gcu                                               23


<210> 2286
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2286
ccugagaaaa gggccaa                                                      17


<210> 2287
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2287
uuggcccuuu ucucagg                                                      17


<210> 2288
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2288
ggccacugag ucagcacca                                                    19


<210> 2289
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2289
uggugcugac ucaguggcc                                                    19


<210> 2290
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2290
agggcauguc cagggggu                                                     18


<210> 2291
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2291
acccccugga caugcccu                                                     18


<210> 2292
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2292
gccuggagcu acuccaccau cuc                                               23


<210> 2293
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2293
gagauggugg aguagcucca ggc                                               23


<210> 2294
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2294
caguguucag agaugga                                                      17


<210> 2295
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2295
uccaucucug aacacug                                                      17


<210> 2296
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2296
aucugaccug augaaggu                                                     18


<210> 2297
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2297
accuucauca ggucagau                                                     18


<210> 2298
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2298
ccagaggugg ggacugag                                                     18


<210> 2299
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2299
cucagucccc accucugg                                                     18


<210> 2300
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2300
ccccgccacc gccuugg                                                      17


<210> 2301
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2301
ccaaggcggu ggcgggg                                                      17


<210> 2302
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2302
caguuggguc uaggggucag ga                                                22


<210> 2303
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2303
uccugacccc uagacccaac ug                                                22


<210> 2304
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2304
cuuggggcau ggaguccca                                                    19


<210> 2305
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2305
ugggacucca ugccccaag                                                    19


<210> 2306
<211> 16
<212> RNA
<213> Homo sapiens

<400> 2306
aggaaacagg gaccca                                                       16


<210> 2307
<211> 16
<212> RNA
<213> Homo sapiens

<400> 2307
ugggucccug uuuccu                                                       16


<210> 2308
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2308
gacauucaga cuaccug                                                      17


<210> 2309
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2309
cagguagucu gaauguc                                                      17


<210> 2310
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2310
auucuaagug ccuuggcc                                                     18


<210> 2311
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2311
ggccaaggca cuuagaau                                                     18


<210> 2312
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2312
acucagucau ggucauu                                                      17


<210> 2313
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2313
aaugaccaug acugagu                                                      17


<210> 2314
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2314
cugugggcuc agcucuggg                                                    19


<210> 2315
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2315
cccagagcug agcccacag                                                    19


<210> 2316
<211> 16
<212> RNA
<213> Homo sapiens

<400> 2316
cuaggaggcc uuggcc                                                       16


<210> 2317
<211> 16
<212> RNA
<213> Homo sapiens

<400> 2317
ggccaaggcc uccuag                                                       16


<210> 2318
<211> 16
<212> RNA
<213> Homo sapiens

<400> 2318
uccagcucgg uggcac                                                       16


<210> 2319
<211> 16
<212> RNA
<213> Homo sapiens

<400> 2319
gugccaccga gcugga                                                       16


<210> 2320
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2320
ggcuccuccu cucaggaugu g                                                 21


<210> 2321
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2321
cacauccuga gaggaggagc c                                                 21


<210> 2322
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2322
gcaggcacag acagcccugg c                                                 21


<210> 2323
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2323
gccagggcug ucugugccug c                                                 21


<210> 2324
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2324
ucagggaguc aggggagggc                                                   20


<210> 2325
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2325
gcccuccccu gacucccuga                                                   20


<210> 2326
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2326
gggggaagaa aaggugggg                                                    19


<210> 2327
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2327
ccccaccuuu ucuuccccc                                                    19


<210> 2328
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2328
cauucaacua gugauugu                                                     18


<210> 2329
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2329
acaaucacua guugaaug                                                     18


<210> 2330
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2330
cagcaguccc ucccccug                                                     18


<210> 2331
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2331
cagggggagg gacugcug                                                     18


<210> 2332
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2332
ccaauuacca cuucuuu                                                      17


<210> 2333
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2333
aaagaagugg uaauugg                                                      17


<210> 2334
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2334
cucagugacu caugugc                                                      17


<210> 2335
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2335
gcacaugagu cacugag                                                      17


<210> 2336
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2336
gcaguucuga gcacaguaca c                                                 21


<210> 2337
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2337
guguacugug cucagaacug c                                                 21


<210> 2338
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2338
cuaggggguu ugcccuug                                                     18


<210> 2339
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2339
caagggcaaa cccccuag                                                     18


<210> 2340
<211> 16
<212> RNA
<213> Homo sapiens

<400> 2340
cucuccuccc ggcuuc                                                       16


<210> 2341
<211> 16
<212> RNA
<213> Homo sapiens

<400> 2341
gaagccggga ggagag                                                       16


<210> 2342
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2342
gaguguaguu cugagcagag c                                                 21


<210> 2343
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2343
gcucugcuca gaacuacacu c                                                 21


<210> 2344
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2344
gggucccggg gagggggg                                                     18


<210> 2345
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2345
ccccccuccc cgggaccc                                                     18


<210> 2346
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2346
uaaaauuugc auccagga                                                     18


<210> 2347
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2347
uccuggaugc aaauuuua                                                     18


<210> 2348
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2348
uggggcucag cgaguuu                                                      17


<210> 2349
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2349
aaacucgcug agcccca                                                      17


<210> 2350
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2350
gggcucacau caccccau                                                     18


<210> 2351
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2351
auggggugau gugagccc                                                     18


<210> 2352
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2352
gcggcgaguc cgacucau                                                     18


<210> 2353
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2353
augagucgga cucgccgc                                                     18


<210> 2354
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2354
accccacucc ugguacc                                                      17


<210> 2355
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2355
gguaccagga guggggu                                                      17


<210> 2356
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2356
ucucccuuga gggcacuuu                                                    19


<210> 2357
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2357
aaagugcccu caagggaga                                                    19


<210> 2358
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2358
uugucugcug aguuucc                                                      17


<210> 2359
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2359
ggaaacucag cagacaa                                                      17


<210> 2360
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2360
gcauugugca gggcuauca                                                    19


<210> 2361
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2361
ugauagcccu gcacaaugc                                                    19


<210> 2362
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2362
ugcccuccuu ucuucccuc                                                    19


<210> 2363
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2363
gagggaagaa aggagggca                                                    19


<210> 2364
<211> 16
<212> RNA
<213> Homo sapiens

<400> 2364
uucagcagga acagcu                                                       16


<210> 2365
<211> 16
<212> RNA
<213> Homo sapiens

<400> 2365
agcuguuccu gcugaa                                                       16


<210> 2366
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2366
ccccugggcc ggccuugg                                                     18


<210> 2367
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2367
ccaaggccgg cccagggg                                                     18


<210> 2368
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2368
cagccugaca ggaacag                                                      17


<210> 2369
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2369
cuguuccugu caggcug                                                      17


<210> 2370
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2370
gggagucuac agcaggg                                                      17


<210> 2371
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2371
cccugcugua gacuccc                                                      17


<210> 2372
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2372
cagugcaaug uuuuccuu                                                     18


<210> 2373
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2373
aaggaaaaca uugcacug                                                     18


<210> 2374
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2374
augugggcuc aggcuca                                                      17


<210> 2375
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2375
ugagccugag cccacau                                                      17


<210> 2376
<211> 16
<212> RNA
<213> Homo sapiens

<400> 2376
ugccuuccug ucugug                                                       16


<210> 2377
<211> 16
<212> RNA
<213> Homo sapiens

<400> 2377
cacagacagg aaggca                                                       16


<210> 2378
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2378
cugggacagg aggaggaggc ag                                                22


<210> 2379
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2379
cugccuccuc cuccuguccc ag                                                22


<210> 2380
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2380
gcuggugaca ugagaggc                                                     18


<210> 2381
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2381
gccucucaug ucaccagc                                                     18


<210> 2382
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2382
ugggagcugg acuacuuc                                                     18


<210> 2383
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2383
gaaguagucc agcuccca                                                     18


<210> 2384
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2384
ucccacuacu ucacuuguga                                                   20


<210> 2385
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2385
ucacaaguga aguaguggga                                                   20


<210> 2386
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2386
ccaguguggc ucagcgag                                                     18


<210> 2387
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2387
cucgcugagc cacacugg                                                     18


<210> 2388
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2388
uucugagcug aggacag                                                      17


<210> 2389
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2389
cuguccucag cucagaa                                                      17


<210> 2390
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2390
ccggcauguc cagggca                                                      17


<210> 2391
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2391
ugcccuggac augccgg                                                      17


<210> 2392
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2392
ccuagacacc uccaguuc                                                     18


<210> 2393
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2393
gaacuggagg ugucuagg                                                     18


<210> 2394
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2394
uggagagaaa ggcagua                                                      17


<210> 2395
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2395
uacugccuuu cucucca                                                      17


<210> 2396
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2396
aauguuuuuu ccuguuucc                                                    19


<210> 2397
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2397
ggaaacagga aaaaacauu                                                    19


<210> 2398
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2398
ucccuggagu uucuucuu                                                     18


<210> 2399
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2399
aagaagaaac uccaggga                                                     18


<210> 2400
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2400
cuggagucua ggauucca                                                     18


<210> 2401
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2401
uggaauccua gacuccag                                                     18


<210> 2402
<211> 16
<212> RNA
<213> Homo sapiens

<400> 2402
gcagcauuca uguccc                                                       16


<210> 2403
<211> 16
<212> RNA
<213> Homo sapiens

<400> 2403
gggacaugaa ugcugc                                                       16


<210> 2404
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2404
gaaagagagc ugagugug                                                     18


<210> 2405
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2405
cacacucagc ucucuuuc                                                     18


<210> 2406
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2406
ggccuuguuc cugucccca                                                    19


<210> 2407
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2407
uggggacagg aacaaggcc                                                    19


<210> 2408
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2408
agcccccugg ccccaaaccc                                                   20


<210> 2409
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2409
ggguuugggg ccagggggcu                                                   20


<210> 2410
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2410
cucugggaaa ugggacag                                                     18


<210> 2411
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2411
cugucccauu ucccagag                                                     18


<210> 2412
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2412
ccgcuuucug agcuggac                                                     18


<210> 2413
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2413
guccagcuca gaaagcgg                                                     18


<210> 2414
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2414
ggugaggcua gcuggug                                                      17


<210> 2415
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2415
caccagcuag ccucacc                                                      17


<210> 2416
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2416
acauugccag ggaguuu                                                      17


<210> 2417
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2417
aaacucccug gcaaugu                                                      17


<210> 2418
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2418
cacugugggu acaugcu                                                      17


<210> 2419
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2419
agcauguacc cacagug                                                      17


<210> 2420
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2420
ucccugagca aagccac                                                      17


<210> 2421
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2421
guggcuuugc ucaggga                                                      17


<210> 2422
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2422
gggauucugu agcuuccu                                                     18


<210> 2423
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2423
aggaagcuac agaauccc                                                     18


<210> 2424
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2424
uuagcggugg accgcccugc g                                                 21


<210> 2425
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2425
cgcagggcgg uccaccgcua a                                                 21


<210> 2426
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2426
cugugggcuc agcgcguggg g                                                 21


<210> 2427
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2427
ccccacgcgc ugagcccaca g                                                 21


<210> 2428
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2428
cagccccaca gccucaga                                                     18


<210> 2429
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2429
ucugaggcug uggggcug                                                     18


<210> 2430
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2430
cccugagacc cuaaccuuaa                                                   20


<210> 2431
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2431
uuaagguuag ggucucaggg                                                   20


<210> 2432
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2432
uugcacuugu cucaguga                                                     18


<210> 2433
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2433
ucacugagac aagugcaa                                                     18


<210> 2434
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2434
uguuccucug ucucccagac                                                   20


<210> 2435
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2435
gucugggaga cagaggaaca                                                   20


<210> 2436
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2436
ggcuugcaug ggggacugg                                                    19


<210> 2437
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2437
ccaguccccc augcaagcc                                                    19


<210> 2438
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2438
ccaguuuucc caggauu                                                      17


<210> 2439
<211> 17
<212> RNA
<213> Homo sapiens

<400> 2439
aauccuggga aaacugg                                                      17


<210> 2440
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2440
ccugagaccc uaguuccac                                                    19


<210> 2441
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2441
guggaacuag ggucucagg                                                    19


<210> 2442
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2442
ccucagauca gagccuugc                                                    19


<210> 2443
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2443
gcaaggcucu gaucugagg                                                    19


<210> 2444
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2444
cauugcacuu gucucggucu ga                                                22


<210> 2445
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2445
ucagaccgag acaagugcaa ug                                                22


<210> 2446
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2446
aggcggagac uugggcaauu g                                                 21


<210> 2447
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2447
caauugccca agucuccgcc u                                                 21


<210> 2448
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2448
ccuauucuug guuacuugca cg                                                22


<210> 2449
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2449
cgugcaagua accaagaaua gg                                                22


<210> 2450
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2450
aauggauuuu uggagcagg                                                    19


<210> 2451
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2451
ccugcuccaa aaauccauu                                                    19


<210> 2452
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2452
ugcggggcua gggcuaacag ca                                                22


<210> 2453
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2453
ugcuguuagc ccuagccccg ca                                                22


<210> 2454
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2454
aaaaguaauu gcggauuuug cc                                                22


<210> 2455
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2455
ggcaaaaucc gcaauuacuu uu                                                22


<210> 2456
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2456
caaaaguaau uguggauuuu gu                                                22


<210> 2457
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2457
acaaaaucca caauuacuuu ug                                                22


<210> 2458
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2458
uaagugcuuc cauguuuugg uga                                               23


<210> 2459
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2459
ucaccaaaac auggaagcac uua                                               23


<210> 2460
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2460
acuuaaacgu ggauguacuu gcu                                               23


<210> 2461
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2461
agcaaguaca uccacguuua agu                                               23


<210> 2462
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2462
cuauacaauc uacugucuuu c                                                 21


<210> 2463
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2463
gaaagacagu agauuguaua g                                                 21


<210> 2464
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2464
ugagguagua gguuguauag uu                                                22


<210> 2465
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2465
aacuauacaa ccuacuaccu ca                                                22


<210> 2466
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2466
cuguacagcc uccuagcuuu cc                                                22


<210> 2467
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2467
ggaaagcuag gaggcuguac ag                                                22


<210> 2468
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2468
caccaggcau uguggucucc                                                   20


<210> 2469
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2469
ggagaccaca augccuggug                                                   20


<210> 2470
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2470
ugaguaccgc caugucuguu ggg                                               23


<210> 2471
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2471
cccaacagac auggcgguac uca                                               23


<210> 2472
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2472
uacccagagc augcagugug aa                                                22


<210> 2473
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2473
uucacacugc augcucuggg ua                                                22


<210> 2474
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2474
aagugcuguc auagcugagg uc                                                22


<210> 2475
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2475
gaccucagcu augacagcac uu                                                22


<210> 2476
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2476
cacucagccu ugagggcacu uuc                                               23


<210> 2477
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2477
gaaagugccc ucaaggcuga gug                                               23


<210> 2478
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2478
ucgacagcac gacacugccu uc                                                22


<210> 2479
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2479
gaaggcagug ucgugcuguc ga                                                22


<210> 2480
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2480
uagguaguuu ccuguuguug gg                                                22


<210> 2481
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2481
cccaacaaca ggaaacuacc ua                                                22


<210> 2482
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2482
uacaguacug ugauaacuga a                                                 21


<210> 2483
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2483
uucaguuauc acaguacugu a                                                 21


<210> 2484
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2484
caguuaucac agugcugaug cu                                                22


<210> 2485
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2485
agcaucagca cugugauaac ug                                                22


<210> 2486
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2486
ugugcaaauc uaugcaaaac uga                                               23


<210> 2487
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2487
ucaguuuugc auagauuugc aca                                               23


<210> 2488
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2488
aguuuugcau aguugcacua ca                                                22


<210> 2489
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2489
uguagugcaa cuaugcaaaa cu                                                22


<210> 2490
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2490
aguuuugcag guuugcaucc agc                                               23


<210> 2491
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2491
gcuggaugca aaccugcaaa acu                                               23


<210> 2492
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2492
aguuuugcag guuugcauuu ca                                                22


<210> 2493
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2493
ugaaaugcaa accugcaaaa cu                                                22


<210> 2494
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2494
ugugcaaauc caugcaaaac uga                                               23


<210> 2495
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2495
ucaguuuugc auggauuugc aca                                               23


<210> 2496
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2496
uacugcauca ggaacugauu gga                                               23


<210> 2497
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2497
uccaaucagu uccugaugca gua                                               23


<210> 2498
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2498
augguuccgu caagcaccau gg                                                22


<210> 2499
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2499
ccauggugcu ugacggaacc au                                                22


<210> 2500
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2500
agcuacaucu ggcuacuggg u                                                 21


<210> 2501
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2501
acccaguagc cagauguagc u                                                 21


<210> 2502
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2502
cucaguagcc aguguagauc cu                                                22


<210> 2503
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2503
aggaucuaca cuggcuacug ag                                                22


<210> 2504
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2504
uuaucagaau cuccaggggu ac                                                22


<210> 2505
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2505
guaccccugg agauucugau aa                                                22


<210> 2506
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2506
aucaacagac auuaauuggg cgc                                               23


<210> 2507
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2507
gcgcccaauu aaugucuguu gau                                               23


<210> 2508
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2508
caaaacguga ggcgcugcua u                                                 21


<210> 2509
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2509
auagcagcgc cucacguuuu g                                                 21


<210> 2510
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2510
cagcagcaau ucauguuuug aa                                                22


<210> 2511
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2511
uucaaaacau gaauugcugc ug                                                22


<210> 2512
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2512
uucacaggga ggugucau                                                     18


<210> 2513
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2513
augacaccuc ccugugaa                                                     18


<210> 2514
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2514
gcggagagag aauggggagc                                                   20


<210> 2515
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2515
gcuccccauu cucucuccgc                                                   20


<210> 2516
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2516
ccugcgaguc uccggcggug g                                                 21


<210> 2517
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2517
ccaccgccgg agacucgcag g                                                 21


<210> 2518
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2518
gggcuagggc cugcugcccc c                                                 21


<210> 2519
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2519
gggggcagca ggcccuagcc c                                                 21


<210> 2520
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2520
uucugcugcc ggccaaggc                                                    19


<210> 2521
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2521
gccuuggccg gcagcagaa                                                    19


<210> 2522
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2522
uccucaucac acugcaccuu ag                                                22


<210> 2523
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2523
cuaaggugca gugugaugag ga                                                22


<210> 2524
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2524
gguagugagu uaucagcuac                                                   20


<210> 2525
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2525
guagcugaua acucacuacc                                                   20


<210> 2526
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2526
gauauucaga ggcuaggugg                                                   20


<210> 2527
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2527
ccaccuagcc ucugaauauc                                                   20


<210> 2528
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2528
acggcccagg cggcauuggu g                                                 21


<210> 2529
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2529
caccaaugcc gccugggccg u                                                 21


<210> 2530
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2530
agcaugacag aggagaggug g                                                 21


<210> 2531
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2531
ccaccucucc ucugucaugc u                                                 21


<210> 2532
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2532
gggaagagcu guacggccuu c                                                 21


<210> 2533
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2533
gaaggccgua cagcucuucc c                                                 21


<210> 2534
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2534
ccgccugagc uagcugugg                                                    19


<210> 2535
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2535
ccacagcuag cucaggcgg                                                    19


<210> 2536
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2536
uuggaagcuu ggaccaacua gcug                                              24


<210> 2537
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2537
cagcuaguug guccaagcuu ccaa                                              24


<210> 2538
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2538
ucuagugcgg gcguucccg                                                    19


<210> 2539
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2539
cgggaacgcc cgcacuaga                                                    19


<210> 2540
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2540
aggagcagug ccggccaagg cgcc                                              24


<210> 2541
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2541
ggcgccuugg ccggcacugc uccu                                              24


<210> 2542
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2542
gaauacgucu gguugaucc                                                    19


<210> 2543
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2543
ggaucaacca gacguauuc                                                    19


<210> 2544
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2544
cuuauaucag aggcuguggg                                                   20


<210> 2545
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2545
cccacagccu cugauauaag                                                   20


<210> 2546
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2546
uuccgccagu cgguggccgg                                                   20


<210> 2547
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2547
ccggccaccg acuggcggaa                                                   20


<210> 2548
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2548
aaggggcugg gggagcaca                                                    19


<210> 2549
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2549
ugugcucccc cagccccuu                                                    19


<210> 2550
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2550
agguugggau cgguugcaau gcu                                               23


<210> 2551
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2551
agcauugcaa ccgaucccaa ccu                                               23


<210> 2552
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2552
ggguggggau uuguugcauu ac                                                22


<210> 2553
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2553
guaaugcaac aaauccccac cc                                                22


<210> 2554
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2554
uauugcacuu gucccggccu gu                                                22


<210> 2555
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2555
acaggccggg acaagugcaa ua                                                22


<210> 2556
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2556
uauugcacuc gucccggccu cc                                                22


<210> 2557
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2557
ggaggccggg acgagugcaa ua                                                22


<210> 2558
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2558
agggacggga cgcggugcag ug                                                22


<210> 2559
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2559
cacugcaccg cgucccgucc cu                                                22


<210> 2560
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2560
aucacauugc cagggauuuc c                                                 21


<210> 2561
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2561
ggaaaucccu ggcaauguga u                                                 21


<210> 2562
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2562
gggguuccug gggaugggau uu                                                22


<210> 2563
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2563
aaaucccauc cccaggaacc cc                                                22


<210> 2564
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2564
acugcaguga aggcacuugu ag                                                22


<210> 2565
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2565
cuacaagugc cuucacugca gu                                                22


<210> 2566
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2566
agcuacauug ucugcugggu uuc                                               23


<210> 2567
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2567
gaaacccagc agacaaugua gcu                                               23


<210> 2568
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2568
accuggcaua caauguagau uu                                                22


<210> 2569
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2569
aaaucuacau uguaugccag gu                                                22


<210> 2570
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2570
ucguaccgug aguaauaaug cg                                                22


<210> 2571
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2571
cgcauuauua cucacgguac ga                                                22


<210> 2572
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2572
cauuauuacu uuugguacgc g                                                 21


<210> 2573
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2573
cgcguaccaa aaguaauaau g                                                 21


<210> 2574
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2574
uacuccagag ggcgucacuc aug                                               23


<210> 2575
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2575
caugagugac gcccucugga gua                                               23


<210> 2576
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2576
ucccacguug uggcccagca g                                                 21


<210> 2577
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2577
cugcugggcc acaacguggg a                                                 21


<210> 2578
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2578
ccucaccacc ccuucugccu gca                                               23


<210> 2579
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2579
ugcaggcaga agggguggug agg                                               23


<210> 2580
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2580
cugcaggcag aaguggggcu gaca                                              24


<210> 2581
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2581
ugucagcccc acuucugccu gcag                                              24


<210> 2582
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2582
ccaaaccagu cgugccugug g                                                 21


<210> 2583
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2583
ccacaggcac gacugguuug g                                                 21


<210> 2584
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2584
cucaaaccgg cugugccugu gg                                                22


<210> 2585
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2585
ccacaggcac agccgguuug ag                                                22


<210> 2586
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2586
acaggcacga cugguuuggc a                                                 21


<210> 2587
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2587
ugccaaacca gucgugccug u                                                 21


<210> 2588
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2588
uccgaacucu ccauuccucu gc                                                22


<210> 2589
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2589
gcagaggaau ggagaguucg ga                                                22


<210> 2590
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2590
ugggaauggg gguaagggcc                                                   20


<210> 2591
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2591
ggcccuuacc cccauuccca                                                   20


<210> 2592
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2592
aggcgaugug gggauguaga ga                                                22


<210> 2593
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2593
ucucuacauc cccacaucgc cu                                                22


<210> 2594
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2594
uaguggucag agggcuuaug a                                                 21


<210> 2595
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2595
ucauaagccc ucugaccacu a                                                 21


<210> 2596
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2596
ucugacauca gugauucucc ug                                                22


<210> 2597
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2597
caggagaauc acugauguca ga                                                22


<210> 2598
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2598
cgcgccugca ggaacuggua ga                                                22


<210> 2599
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2599
ucuaccaguu ccugcaggcg cg                                                22


<210> 2600
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2600
ugggcagggg cuuauuguag gag                                               23


<210> 2601
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2601
cuccuacaau aagccccugc cca                                               23


<210> 2602
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2602
ugcagggguc gggugggcca gg                                                22


<210> 2603
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2603
ccuggcccac ccgaccccug ca                                                22


<210> 2604
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2604
aggcgcaccc gaccacaugc                                                   20


<210> 2605
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2605
gcaugugguc gggugcgccu                                                   20


<210> 2606
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2606
auaguccgag uaacgucggg gc                                                22


<210> 2607
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2607
gccccgacgu uacucggacu au                                                22


<210> 2608
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2608
cugggcccgc ggcgggcgug ggg                                               23


<210> 2609
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2609
ccccacgccc gccgcgggcc cag                                               23


<210> 2610
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2610
uacuuggaaa ggcaucaguu g                                                 21


<210> 2611
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2611
caacugaugc cuuuccaagu a                                                 21


<210> 2612
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2612
ugcaacgaac cugagccacu ga                                                22


<210> 2613
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2613
ucaguggcuc agguucguug ca                                                22


<210> 2614
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2614
ugcaacuuac cugagucauu ga                                                22


<210> 2615
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2615
ucaaugacuc agguaaguug ca                                                22


<210> 2616
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2616
cacugugucc uuucugcgua g                                                 21


<210> 2617
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2617
cuacgcagaa aggacacagu g                                                 21


<210> 2618
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2618
cacuggcucc uuucugggua ga                                                22


<210> 2619
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2619
ucuacccaga aaggagccag ug                                                22


<210> 2620
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2620
cacuguuucc uuucugagug ga                                                22


<210> 2621
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2621
uccacucaga aaggaaacag ug                                                22


<210> 2622
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2622
uauucagaaa ggugccaguc a                                                 21


<210> 2623
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2623
ugacuggcac cuuucugaau a                                                 21


<210> 2624
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2624
auuccuagaa auuguucaua                                                   20


<210> 2625
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2625
uaugaacaau uucuaggaau                                                   20


<210> 2626
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2626
uaauacuguc ugguaaaacc gu                                                22


<210> 2627
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2627
acgguuuuac cagacaguau ua                                                22


<210> 2628
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2628
ugaaacauac acgggaaacc uc                                                22


<210> 2629
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2629
gagguuuccc guguauguuu ca                                                22


<210> 2630
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2630
cuauacaacc uacugccuuc cc                                                22


<210> 2631
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2631
gggaaggcag uagguuguau ag                                                22


<210> 2632
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2632
ugagguagua gguugugugg uu                                                22


<210> 2633
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2633
aaccacacaa ccuacuaccu ca                                                22


<210> 2634
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2634
uaacacuguc ugguaacgau gu                                                22


<210> 2635
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2635
acaucguuac cagacagugu ua                                                22


<210> 2636
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2636
caucuuaccg gacagugcug ga                                                22


<210> 2637
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2637
uccagcacug uccgguaaga ug                                                22


<210> 2638
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2638
uaauacugcc ugguaaugau ga                                                22


<210> 2639
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2639
ucaucauuac caggcaguau ua                                                22


<210> 2640
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2640
caucuuacug ggcagcauug ga                                                22


<210> 2641
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2641
uccaaugcug cccaguaaga ug                                                22


<210> 2642
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2642
uaauacugcc ggguaaugau gga                                               23


<210> 2643
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2643
uccaucauua cccggcagua uua                                               23


<210> 2644
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2644
cgucuuaccc agcaguguuu gg                                                22


<210> 2645
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2645
ccaaacacug cuggguaaga cg                                                22


<210> 2646
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2646
uccagcauca gugauuuugu ug                                                22


<210> 2647
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2647
caacaaaauc acugaugcug ga                                                22


<210> 2648
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2648
uacaguauag augauguacu                                                   20


<210> 2649
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2649
aguacaucau cuauacugua                                                   20


<210> 2650
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2650
ggauaucauc auauacugua ag                                                22


<210> 2651
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2651
cuuacaguau augaugauau cc                                                22


<210> 2652
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2652
cggggcagcu caguacagga u                                                 21


<210> 2653
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2653
auccuguacu gagcugcccc g                                                 21


<210> 2654
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2654
uccuucugcu ccguccccca g                                                 21


<210> 2655
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2655
cugggggacg gagcagaagg a                                                 21


<210> 2656
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2656
cgggggcggg gccgaagcgc g                                                 21


<210> 2657
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2657
cgcgcuucgg ccccgccccc g                                                 21


<210> 2658
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2658
uccugcgcgu cccagaugcc c                                                 21


<210> 2659
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2659
gggcaucugg gacgcgcagg a                                                 21


<210> 2660
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2660
caucagaauu cauggaggcu ag                                                22


<210> 2661
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2661
cuagccucca ugaauucuga ug                                                22


<210> 2662
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2662
agcuuccaug acuccugaug ga                                                22


<210> 2663
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2663
uccaucagga gucauggaag cu                                                22


<210> 2664
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2664
ugacagcgcc cugccuggcu c                                                 21


<210> 2665
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2665
gagccaggca gggcgcuguc a                                                 21


<210> 2666
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2666
agcgcgggcu gagcgcugcc aguc                                              24


<210> 2667
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2667
gacuggcagc gcucagcccg cgcu                                              24


<210> 2668
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2668
cugggaggug ugauaucgug gu                                                22


<210> 2669
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2669
accacgauau cacaccuccc ag                                                22


<210> 2670
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2670
ugugauauca ugguuccugg ga                                                22


<210> 2671
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2671
ucccaggaac caugauauca ca                                                22


<210> 2672
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2672
aggugcucca ggcuggcuca ca                                                22


<210> 2673
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2673
ugugagccag ccuggagcac cu                                                22


<210> 2674
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2674
gagcaaugua gguagacugu uu                                                22


<210> 2675
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2675
aaacagucua ccuacauugc uc                                                22


<210> 2676
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2676
uguccucuag ggccugcagu cu                                                22


<210> 2677
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2677
agacugcagg cccuagagga ca                                                22


<210> 2678
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2678
aaaggcauaa aaccaagaca                                                   20


<210> 2679
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2679
ugucuugguu uuaugccuuu                                                   20


<210> 2680
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2680
uaacgcauaa uauggacaug u                                                 21


<210> 2681
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2681
acauguccau auuaugcguu a                                                 21


<210> 2682
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2682
uugaggaaaa gauggucuua uu                                                22


<210> 2683
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2683
aauaagacca ucuuuuccuc aa                                                22


<210> 2684
<211> 26
<212> RNA
<213> Homo sapiens

<400> 2684
aagaggaaga aauggcuggu ucucag                                            26


<210> 2685
<211> 26
<212> RNA
<213> Homo sapiens

<400> 2685
cugagaacca gccauuucuu ccucuu                                            26


<210> 2686
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2686
gcucggacug agcagguggg                                                   20


<210> 2687
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2687
cccaccugcu caguccgagc                                                   20


<210> 2688
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2688
acagggccgc agauggagac u                                                 21


<210> 2689
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2689
agucuccauc ugcggcccug u                                                 21


<210> 2690
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2690
gcagagaaca aaggacucag u                                                 21


<210> 2691
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2691
acugaguccu uuguucucug c                                                 21


<210> 2692
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2692
acugauuauc uuaacucucu ga                                                22


<210> 2693
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2693
ucagagaguu aagauaauca gu                                                22


<210> 2694
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2694
ucucugagua ccauaugccu ugu                                               23


<210> 2695
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2695
acaaggcaua ugguacucag aga                                               23


<210> 2696
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2696
aacuaguaau guuggauuag gg                                                22


<210> 2697
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2697
cccuaaucca acauuacuag uu                                                22


<210> 2698
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2698
auauguauau gugacugcua cu                                                22


<210> 2699
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2699
aguagcaguc acauauacau au                                                22


<210> 2700
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2700
uggccaaaaa gcaggcagag a                                                 21


<210> 2701
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2701
ucucugccug cuuuuuggcc a                                                 21


<210> 2702
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2702
ggaggaaccu uggagcuucg gc                                                22


<210> 2703
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2703
gccgaagcuc caagguuccu cc                                                22


<210> 2704
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2704
gaggcugaug ugaguagacc acu                                               23


<210> 2705
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2705
aguggucuac ucacaucagc cuc                                               23


<210> 2706
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2706
cuguccuaag guuguugagu u                                                 21


<210> 2707
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2707
aacucaacaa ccuuaggaca g                                                 21


<210> 2708
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2708
ucuucaaccu caggacuugc a                                                 21


<210> 2709
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2709
ugcaaguccu gagguugaag a                                                 21


<210> 2710
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2710
ugugauauca ugguuccugg ga                                                22


<210> 2711
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2711
ucccaggaac caugauauca ca                                                22


<210> 2712
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2712
cugggaggug ugauauugug gu                                                22


<210> 2713
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2713
accacaauau cacaccuccc ag                                                22


<210> 2714
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2714
cagguagaua uuugauaggc au                                                22


<210> 2715
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2715
augccuauca aauaucuacc ug                                                22


<210> 2716
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2716
gccuaucaca uaucugccug u                                                 21


<210> 2717
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2717
acaggcagau augugauagg c                                                 21


<210> 2718
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2718
gggcuggggc gcggggaggu                                                   20


<210> 2719
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2719
accuccccgc gccccagccc                                                   20


<210> 2720
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2720
ugcuuccuuu cagagggu                                                     18


<210> 2721
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2721
acccucugaa aggaagca                                                     18


<210> 2722
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2722
ugaguuggcc aucugaguga g                                                 21


<210> 2723
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2723
cucacucaga uggccaacuc a                                                 21


<210> 2724
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2724
aacauucauu guugucggug ggu                                               23


<210> 2725
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2725
acccaccgac aacaaugaau guu                                               23


<210> 2726
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2726
ucacagugaa ccggucucuu u                                                 21


<210> 2727
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2727
aaagagaccg guucacugug a                                                 21


<210> 2728
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2728
caacaaauca cagucugcca ua                                                22


<210> 2729
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2729
uauggcagac ugugauuugu ug                                                22


<210> 2730
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2730
cucacugaac aaugaaugca a                                                 21


<210> 2731
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2731
uugcauucau uguucaguga g                                                 21


<210> 2732
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2732
aacauucauu gcugucggug ggu                                               23


<210> 2733
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2733
acccaccgac agcaaugaau guu                                               23


<210> 2734
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2734
accaucgacc guugauugua cc                                                22


<210> 2735
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2735
gguacaauca acggucgaug gu                                                22


<210> 2736
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2736
aacauucaac gcugucggug agu                                               23


<210> 2737
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2737
acucaccgac agcguugaau guu                                               23


<210> 2738
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2738
accacugacc guugacugua cc                                                22


<210> 2739
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2739
gguacaguca acggucagug gu                                                22


<210> 2740
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2740
cuguugccac uaaccucaac cu                                                22


<210> 2741
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2741
agguugaggu uaguggcaac ag                                                22


<210> 2742
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2742
auaagacgag caaaaagcuu gu                                                22


<210> 2743
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2743
acaagcuuuu ugcucgucuu au                                                22


<210> 2744
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2744
auaagacgaa caaaagguuu gu                                                22


<210> 2745
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2745
acaaaccuuu uguucgucuu au                                                22


<210> 2746
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2746
agggagggac gggggcugug c                                                 21


<210> 2747
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2747
gcacagcccc cgucccuccc u                                                 21


<210> 2748
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2748
ucuggcuccg ugucuucacu ccc                                               23


<210> 2749
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2749
gggagugaag acacggagcc aga                                               23


<210> 2750
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2750
uggaauguaa agaaguaugu au                                                22


<210> 2751
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2751
auacauacuu cuuuacauuc ca                                                22


<210> 2752
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2752
aacaucacag caagucugug cu                                                22


<210> 2753
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2753
agcacagacu ugcugugaug uu                                                22


<210> 2754
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2754
uuaagacuug cagugauguu u                                                 21


<210> 2755
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2755
aaacaucacu gcaagucuua a                                                 21


<210> 2756
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2756
aacaucacug caagucuuaa ca                                                22


<210> 2757
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2757
uguuaagacu ugcagugaug uu                                                22


<210> 2758
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2758
acagacuugc ugugauguuc a                                                 21


<210> 2759
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2759
ugaacaucac agcaagucug u                                                 21


<210> 2760
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2760
aaaccguuac cauuacugag uu                                                22


<210> 2761
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2761
aacucaguaa ugguaacggu uu                                                22


<210> 2762
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2762
uagcaagaga accauuacca uu                                                22


<210> 2763
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2763
aaugguaaug guucucuugc ua                                                22


<210> 2764
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2764
ugaggggcag agagcgagac uuu                                               23


<210> 2765
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2765
aaagucucgc ucucugcccc uca                                               23


<210> 2766
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2766
caagcucgcu ucuauggguc ug                                                22


<210> 2767
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2767
cagacccaua gaagcgagcu ug                                                22


<210> 2768
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2768
aacccguaga uccgaucuug ug                                                22


<210> 2769
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2769
cacaagaucg gaucuacggg uu                                                22


<210> 2770
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2770
caagcucgug ucuguggguc cg                                                22


<210> 2771
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2771
cggacccaca gacacgagcu ug                                                22


<210> 2772
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2772
cacccguaga accgaccuug cg                                                22


<210> 2773
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2773
cgcaaggucg guucuacggg ug                                                22


<210> 2774
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2774
uggagacgcg gcccuguugg agu                                               23


<210> 2775
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2775
acuccaacag ggccgcgucu cca                                               23


<210> 2776
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2776
ucuacagugc acgugucucc agu                                               23


<210> 2777
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2777
acuggagaca cgugcacugu aga                                               23


<210> 2778
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2778
caaauucgua ucuaggggaa ua                                                22


<210> 2779
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2779
uauuccccua gauacgaauu ug                                                22


<210> 2780
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2780
uacccuguag auccgaauuu gug                                               23


<210> 2781
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2781
cacaaauucg gaucuacagg gua                                               23


<210> 2782
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2782
ccugcagcga cuugauggcu ucc                                               23


<210> 2783
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2783
ggaagccauc aagucgcugc agg                                               23


<210> 2784
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2784
ucagugcacu acagaacuuu gu                                                22


<210> 2785
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2785
acaaaguucu guagugcacu ga                                                22


<210> 2786
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2786
aaaguucuga gacacuccga cu                                                22


<210> 2787
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2787
agucggagug ucucagaacu uu                                                22


<210> 2788
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2788
ccuguucucc auuacuuggc uc                                                22


<210> 2789
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2789
gagccaagua auggagaaca gg                                                22


<210> 2790
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2790
uucaaguaau ucaggauagg u                                                 21


<210> 2791
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2791
accuauccug aauuacuuga a                                                 21


<210> 2792
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2792
gcccugaacg aggggucugg ag                                                22


<210> 2793
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2793
cuccagaccc cucguucagg gc                                                22


<210> 2794
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2794
gcugacuccu aguccagggc uc                                                22


<210> 2795
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2795
gagcccugga cuaggaguca gc                                                22


<210> 2796
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2796
aucacacaaa ggcaacuuuu gu                                                22


<210> 2797
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2797
acaaaaguug ccuuugugug au                                                22


<210> 2798
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2798
agagguugcc cuuggugaau uc                                                22


<210> 2799
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2799
gaauucacca agggcaaccu cu                                                22


<210> 2800
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2800
gguagauuuu ccuucuaugg u                                                 21


<210> 2801
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2801
accauagaag gaaaaucuac c                                                 21


<210> 2802
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2802
aucauagagg aaaauccacg u                                                 21


<210> 2803
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2803
acguggauuu uccucuauga u                                                 21


<210> 2804
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2804
guagauucuc cuucuaugag ua                                                22


<210> 2805
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2805
uacucauaga aggagaaucu ac                                                22


<210> 2806
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2806
cugguacagg ccugggggac ag                                                22


<210> 2807
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2807
cuguccccca ggccuguacc ag                                                22


<210> 2808
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2808
ucucccaacc cuuguaccag ug                                                22


<210> 2809
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2809
cacugguaca aggguuggga ga                                                22


<210> 2810
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2810
acggguuagg cucuugggag cu                                                22


<210> 2811
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2811
agcucccaag agccuaaccc gu                                                22


<210> 2812
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2812
ucacaaguca ggcucuuggg ac                                                22


<210> 2813
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2813
gucccaagag ccugacuugu ga                                                22


<210> 2814
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2814
aacccguaga uccgaacuug ug                                                22


<210> 2815
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2815
cacaaguucg gaucuacggg uu                                                22


<210> 2816
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2816
cuguacaggc cacugccuug c                                                 21


<210> 2817
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2817
gcaaggcagu ggccuguaca g                                                 21


<210> 2818
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2818
ugagguagua guuuguacag uu                                                22


<210> 2819
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2819
aacuguacaa acuacuaccu ca                                                22


<210> 2820
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2820
ucccugagac ccuaacuugu ga                                                22


<210> 2821
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2821
ucacaaguua gggucucagg ga                                                22


<210> 2822
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2822
caagcuugua ucuauaggua ug                                                22


<210> 2823
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2823
cauaccuaua gauacaagcu ug                                                22


<210> 2824
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2824
aaagugcugc gacauuugag cgu                                               23


<210> 2825
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2825
acgcucaaau gucgcagcac uuu                                               23


<210> 2826
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2826
uuuagagacg gggucuugcu cu                                                22


<210> 2827
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2827
agagcaagac cccgucucua aa                                                22


<210> 2828
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2828
uggcccugac ugaagaccag cagu                                              24


<210> 2829
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2829
acugcugguc uucagucagg gcca                                              24


<210> 2830
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2830
gcgacccaua cuugguuuca g                                                 21


<210> 2831
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2831
cugaaaccaa guaugggucg c                                                 21


<210> 2832
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2832
gaaaucaagc gugggugaga cc                                                22


<210> 2833
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2833
ggucucaccc acgcuugauu uc                                                22


<210> 2834
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2834
cccugggccu cugcucccca g                                                 21


<210> 2835
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2835
cuggggagca gaggcccagg g                                                 21


<210> 2836
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2836
uggggagcug aggcucuggg ggug                                              24


<210> 2837
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2837
cacccccaga gccucagcuc ccca                                              24


<210> 2838
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2838
ggggagcugu ggaagcagua                                                   20


<210> 2839
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2839
uacugcuucc acagcucccc                                                   20


<210> 2840
<211> 25
<212> RNA
<213> Homo sapiens

<400> 2840
cuagugaggg acagaaccag gauuc                                             25


<210> 2841
<211> 25
<212> RNA
<213> Homo sapiens

<400> 2841
gaauccuggu ucugucccuc acuag                                             25


<210> 2842
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2842
agagucuugu gaugucuugc                                                   20


<210> 2843
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2843
gcaagacauc acaagacucu                                                   20


<210> 2844
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2844
gcagcagaga auaggacuac guc                                               23


<210> 2845
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2845
gacguagucc uauucucugc ugc                                               23


<210> 2846
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2846
ugagcgccuc gacgacagag ccg                                               23


<210> 2847
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2847
cggcucuguc gucgaggcgc uca                                               23


<210> 2848
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2848
ucccuguccu ccaggagcuc acg                                               23


<210> 2849
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2849
cgugagcucc uggaggacag gga                                               23


<210> 2850
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2850
cuauacggcc uccuagcuuu cc                                                22


<210> 2851
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2851
ggaaagcuag gaggccguau ag                                                22


<210> 2852
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2852
ugagguagga gguuguauag uu                                                22


<210> 2853
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2853
aacuauacaa ccuccuaccu ca                                                22


<210> 2854
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2854
cugcgcaagc uacugccuug cu                                                22


<210> 2855
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2855
agcaaggcag uagcuugcgc ag                                                22


<210> 2856
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2856
ugagguagua guuugugcug uu                                                22


<210> 2857
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2857
aacagcacaa acuacuaccu ca                                                22


<210> 2858
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2858
ugcccugugg acucaguucu gg                                                22


<210> 2859
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2859
ccagaacuga guccacaggg ca                                                22


<210> 2860
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2860
ugguucuaga cuugccaacu a                                                 21


<210> 2861
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2861
uaguuggcaa gucuagaacc a                                                 21


<210> 2862
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2862
ugucugcccg caugccugcc ucu                                               23


<210> 2863
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2863
agaggcaggc augcgggcag aca                                               23


<210> 2864
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2864
aaaaguaauu gcggucuuug gu                                                22


<210> 2865
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2865
accaaagacc gcaauuacuu uu                                                22


<210> 2866
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2866
ucgaggagcu cacagucu                                                     18


<210> 2867
<211> 18
<212> RNA
<213> Homo sapiens

<400> 2867
agacugugag cuccucga                                                     18


<210> 2868
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2868
cuauacaauc uauugccuuc cc                                                22


<210> 2869
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2869
gggaaggcaa uagauuguau ag                                                22


<210> 2870
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2870
cuauacaguc uacugucuuu cc                                                22


<210> 2871
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2871
ggaaagacag uagacuguau ag                                                22


<210> 2872
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2872
ugagguagua gauuguauag uu                                                22


<210> 2873
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2873
aacuauacaa ucuacuaccu ca                                                22


<210> 2874
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2874
aaaaguaauu gugguuuugg cc                                                22


<210> 2875
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2875
ggccaaaacc acaauuacuu uu                                                22


<210> 2876
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2876
aaaaguaauu gcgguuuuug cc                                                22


<210> 2877
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2877
ggcaaaaacc gcaauuacuu uu                                                22


<210> 2878
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2878
ccucugaaau ucaguucuuc ag                                                22


<210> 2879
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2879
cugaagaacu gaauuucaga gg                                                22


<210> 2880
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2880
ugagaacuga auuccauggg uu                                                22


<210> 2881
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2881
aacccaugga auucaguucu ca                                                22


<210> 2882
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2882
acagcaggca cagacaggca gu                                                22


<210> 2883
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2883
acugccuguc ugugccugcu gu                                                22


<210> 2884
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2884
ugccugucua cacuugcugu gc                                                22


<210> 2885
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2885
gcacagcaag uguagacagg ca                                                22


<210> 2886
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2886
uagcaccauc ugaaaucggu ua                                                22


<210> 2887
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2887
uaaccgauuu cagauggugc ua                                                22


<210> 2888
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2888
acugauuucu uuugguguuc ag                                                22


<210> 2889
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2889
cugaacacca aaagaaauca gu                                                22


<210> 2890
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2890
gcugguuuca uauggugguu uaga                                              24


<210> 2891
<211> 24
<212> RNA
<213> Homo sapiens

<400> 2891
ucuaaaccac cauaugaaac cagc                                              24


<210> 2892
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2892
cugguuucac augguggcuu ag                                                22


<210> 2893
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2893
cuaagccacc augugaaacc ag                                                22


<210> 2894
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2894
uagcaccauu ugaaaucagu guu                                               23


<210> 2895
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2895
aacacugauu ucaaauggug cua                                               23


<210> 2896
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2896
uagcaccauu ugaaaucggu ua                                                22


<210> 2897
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2897
uaaccgauuu caaauggugc ua                                                22


<210> 2898
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2898
ugaccgauuu cuccuggugu uc                                                22


<210> 2899
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2899
gaacaccagg agaaaucggu ca                                                22


<210> 2900
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2900
ugucacucgg cucggcccac uac                                               23


<210> 2901
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2901
guagugggcc gagccgagug aca                                               23


<210> 2902
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2902
cugccaauuc cauaggucac ag                                                22


<210> 2903
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2903
cugugaccua uggaauuggc ag                                                22


<210> 2904
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2904
cugaccuaug aauugacagc c                                                 21


<210> 2905
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2905
ggcugucaau ucauagguca g                                                 21


<210> 2906
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2906
acugccccag gugcugcugg                                                   20


<210> 2907
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2907
ccagcagcac cuggggcagu                                                   20


<210> 2908
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2908
aacgccauua ucacacuaaa ua                                                22


<210> 2909
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2909
uauuuagugu gauaauggcg uu                                                22


<210> 2910
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2910
cuuucagucg gauguuugca gc                                                22


<210> 2911
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2911
gcugcaaaca uccgacugaa ag                                                22


<210> 2912
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2912
aauugcacgg uauccaucug ua                                                22


<210> 2913
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2913
uacagaugga uaccgugcaa uu                                                22


<210> 2914
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2914
cggguggauc acgaugcaau uu                                                22


<210> 2915
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2915
aaauugcauc gugauccacc cg                                                22


<210> 2916
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2916
cugggaggug gauguuuacu uc                                                22


<210> 2917
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2917
gaaguaaaca uccaccuccc ag                                                22


<210> 2918
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2918
uguaaacauc cuacacucag cu                                                22


<210> 2919
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2919
agcugagugu aggauguuua ca                                                22


<210> 2920
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2920
cugggagagg guuguuuacu cc                                                22


<210> 2921
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2921
ggaguaaaca acccucuccc ag                                                22


<210> 2922
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2922
cugggagaag gcuguuuacu cu                                                22


<210> 2923
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2923
agaguaaaca gccuucuccc ag                                                22


<210> 2924
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2924
uguaaacauc cuacacucuc agc                                               23


<210> 2925
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2925
gcugagagug uaggauguuu aca                                               23


<210> 2926
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2926
uuuuucauua uugcuccuga cc                                                22


<210> 2927
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2927
ggucaggagc aauaaugaaa aa                                                22


<210> 2928
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2928
ucaagagcaa uaacgaaaaa ugu                                               23


<210> 2929
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2929
acauuuuucg uuauugcucu uga                                               23


<210> 2930
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2930
caaagugcuu acagugcagg uag                                               23


<210> 2931
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2931
cuaccugcac uguaagcacu uug                                               23


<210> 2932
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2932
ggauuccugg aaauacuguu cu                                                22


<210> 2933
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2933
agaacaguau uuccaggaau cc                                                22


<210> 2934
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2934
guccaguuuu cccaggaauc ccu                                               23


<210> 2935
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2935
agggauuccu gggaaaacug gac                                               23


<210> 2936
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2936
acugcauuau gagcacuuaa ag                                                22


<210> 2937
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2937
cuuuaagugc ucauaaugca gu                                                22


<210> 2938
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2938
uaaagugcuu auagugcagg uag                                               23


<210> 2939
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2939
cuaccugcac uauaagcacu uua                                               23


<210> 2940
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2940
gaggguuggg uggaggcucu cc                                                22


<210> 2941
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2941
ggagagccuc cacccaaccc uc                                                22


<210> 2942
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2942
cugugcgugu gacagcggcu ga                                                22


<210> 2943
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2943
ucagccgcug ucacacgcac ag                                                22


<210> 2944
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2944
ccaguggggc ugcuguuauc ug                                                22


<210> 2945
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2945
cagauaacag cagccccacu gg                                                22


<210> 2946
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2946
uguaacagca acuccaugug ga                                                22


<210> 2947
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2947
uccacaugga guugcuguua ca                                                22


<210> 2948
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2948
ucacaguggu cucugggauu au                                                22


<210> 2949
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2949
auaaucccag agaccacugu ga                                                22


<210> 2950
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2950
uaaucucagc uggcaacugu ga                                                22


<210> 2951
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2951
ucacaguugc cagcugagau ua                                                22


<210> 2952
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2952
cagugccucg gcagugcagc cc                                                22


<210> 2953
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2953
gggcugcacu gccgaggcac ug                                                22


<210> 2954
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2954
gugcauugcu guugcauugc                                                   20


<210> 2955
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2955
gcaaugcaac agcaaugcac                                                   20


<210> 2956
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2956
acuggacuug gaggcagaa                                                    19


<210> 2957
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2957
uucugccucc aaguccagu                                                    19


<210> 2958
<211> 25
<212> RNA
<213> Homo sapiens

<400> 2958
acuggacuug gagucagaag agugg                                             25


<210> 2959
<211> 25
<212> RNA
<213> Homo sapiens

<400> 2959
ccacucuucu gacuccaagu ccagu                                             25


<210> 2960
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2960
acuggacuug gagucagaaa                                                   20


<210> 2961
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2961
uuucugacuc caaguccagu                                                   20


<210> 2962
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2962
acuggacuug gagucagga                                                    19


<210> 2963
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2963
uccugacucc aaguccagu                                                    19


<210> 2964
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2964
acuggacuug gagccagaag                                                   20


<210> 2965
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2965
cuucuggcuc caaguccagu                                                   20


<210> 2966
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2966
acugggcuug gagucagaag                                                   20


<210> 2967
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2967
cuucugacuc caagcccagu                                                   20


<210> 2968
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2968
acuggacuug gugucagaug g                                                 21


<210> 2969
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2969
ccaucugaca ccaaguccag u                                                 21


<210> 2970
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2970
acuggacuag gagucagaag g                                                 21


<210> 2971
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2971
ccuucugacu ccuaguccag u                                                 21


<210> 2972
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2972
acuggauuug gagccagaa                                                    19


<210> 2973
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2973
uucuggcucc aaauccagu                                                    19


<210> 2974
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2974
aggaauguuc cuucuuugcc                                                   20


<210> 2975
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2975
ggcaaagaag gaacauuccu                                                   20


<210> 2976
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2976
ucagugcaug acagaacuug g                                                 21


<210> 2977
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2977
ccaaguucug ucaugcacug a                                                 21


<210> 2978
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2978
ucacaccugc cucgcccccc                                                   20


<210> 2979
<211> 20
<212> RNA
<213> Homo sapiens

<400> 2979
ggggggcgag gcagguguga                                                   20


<210> 2980
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2980
gugggcgggg gcaggugugu g                                                 21


<210> 2981
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2981
cacacaccug cccccgccca c                                                 21


<210> 2982
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2982
acgcccuucc cccccuucuu ca                                                22


<210> 2983
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2983
ugaagaaggg ggggaagggc gu                                                22


<210> 2984
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2984
uugcauaugu aggauguccc au                                                22


<210> 2985
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2985
augggacauc cuacauaugc aa                                                22


<210> 2986
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2986
guuugcacgg gugggccuug ucu                                               23


<210> 2987
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2987
agacaaggcc cacccgugca aac                                               23


<210> 2988
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2988
gacuauagaa cuuucccccu ca                                                22


<210> 2989
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2989
ugagggggaa aguucuauag uc                                                22


<210> 2990
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2990
agggggaaag uucuauaguc c                                                 21


<210> 2991
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2991
ggacuauaga acuuuccccc u                                                 21


<210> 2992
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2992
cuuuuugcgg ucugggcuug c                                                 21


<210> 2993
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2993
gcaagcccag accgcaaaaa g                                                 21


<210> 2994
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2994
ucuuguguuc ucuagaucag u                                                 21


<210> 2995
<211> 21
<212> RNA
<213> Homo sapiens

<400> 2995
acugaucuag agaacacaag a                                                 21


<210> 2996
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2996
cccaguguuc agacuaccug uuc                                               23


<210> 2997
<211> 23
<212> RNA
<213> Homo sapiens

<400> 2997
gaacagguag ucugaacacu ggg                                               23


<210> 2998
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2998
acaguagucu gcacauuggu ua                                                22


<210> 2999
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2999
uaaccaaugu gcagacuacu gu                                                22


<210> 3000
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3000
acaguagucu gcacauuggu ua                                                22


<210> 3001
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3001
uaaccaaugu gcagacuacu gu                                                22


<210> 3002
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3002
cccaguguuu agacuaucug uuc                                               23


<210> 3003
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3003
gaacagauag ucuaaacacu ggg                                               23


<210> 3004
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3004
uggaguguga caaugguguu ug                                                22


<210> 3005
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3005
caaacaccau ugucacacuc ca                                                22


<210> 3006
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3006
ugcccuaaau gccccuucug gc                                                22


<210> 3007
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3007
gccagaaggg gcauuuaggg ca                                                22


<210> 3008
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3008
uaaggugcau cuagugcagu uag                                               23


<210> 3009
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3009
cuaacugcac uagaugcacc uua                                               23


<210> 3010
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3010
cuccuauaug augccuuucu uc                                                22


<210> 3011
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3011
gaagaaaggc aucauauagg ag                                                22


<210> 3012
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3012
gaacggcuuc auacaggagu u                                                 21


<210> 3013
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3013
aacuccugua ugaagccguu c                                                 21


<210> 3014
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3014
ugugacuggu ugaccagagg gg                                                22


<210> 3015
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3015
ccccucuggu caaccaguca ca                                                22


<210> 3016
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3016
acugcccuaa gugcuccuuc ugg                                               23


<210> 3017
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3017
ccagaaggag cacuuagggc agu                                               23


<210> 3018
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3018
uaaggugcau cuagugcaga uag                                               23


<210> 3019
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3019
cuaucugcac uagaugcacc uua                                               23


<210> 3020
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3020
cagugcaaug augaaagggc au                                                22


<210> 3021
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3021
augcccuuuc aucauugcac ug                                                22


<210> 3022
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3022
acucuuuccc uguugcacua c                                                 21


<210> 3023
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3023
guagugcaac agggaaagag u                                                 21


<210> 3024
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3024
uuuggcaaug guagaacuca cacu                                              24


<210> 3025
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3025
agugugaguu cuaccauugc caaa                                              24


<210> 3026
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3026
agggcccccc cucaauccug u                                                 21


<210> 3027
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3027
acaggauuga gggggggccc u                                                 21


<210> 3028
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3028
cagugcaaug uuaaaagggc au                                                22


<210> 3029
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3029
augcccuuuu aacauugcac ug                                                22


<210> 3030
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3030
uucacauugu gcuacugucu gc                                                22


<210> 3031
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3031
gcagacagua gcacaaugug aa                                                22


<210> 3032
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3032
ucggauccgu cugagcuugg cu                                                22


<210> 3033
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3033
agccaagcuc agacggaucc ga                                                22


<210> 3034
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3034
cugaagcuca gagggcucug au                                                22


<210> 3035
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3035
aucagagccc ucugagcuuc ag                                                22


<210> 3036
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3036
ccucuucccc uugucucucc ag                                                22


<210> 3037
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3037
cuggagagac aaggggaaga gg                                                22


<210> 3038
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3038
ugagugacag gggaaauggg ga                                                22


<210> 3039
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3039
uccccauuuc cccugucacu ca                                                22


<210> 3040
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3040
ucaggacacu ucugaacuug ga                                                22


<210> 3041
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3041
uccaaguuca gaaguguccu ga                                                22


<210> 3042
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3042
caguucagaa guguuccuga gu                                                22


<210> 3043
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3043
acucaggaac acuucugaac ug                                                22


<210> 3044
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3044
uuucccuuuc cauccuggca g                                                 21


<210> 3045
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3045
cugccaggau ggaaagggaa a                                                 21


<210> 3046
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3046
uugccagggc aggaggugga a                                                 21


<210> 3047
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3047
uuccaccucc ugcccuggca a                                                 21


<210> 3048
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3048
agagauuggu agaaaucagg u                                                 21


<210> 3049
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3049
accugauuuc uaccaaucuc u                                                 21


<210> 3050
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3050
aaucggaccc auuuaaaccg gag                                               23


<210> 3051
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3051
cuccgguuua aauggguccg auu                                               23


<210> 3052
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3052
ucugggcaca ggcggaugga cagg                                              24


<210> 3053
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3053
ccuguccauc cgccugugcc caga                                              24


<210> 3054
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3054
ccagugacug agcuggagcc a                                                 21


<210> 3055
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3055
uggcuccagc ucagucacug g                                                 21


<210> 3056
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3056
aggauaggaa gaaugaagug cu                                                22


<210> 3057
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3057
agcacuucau ucuuccuauc cu                                                22


<210> 3058
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3058
aggagagugg auuccaggug gu                                                22


<210> 3059
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3059
accaccugga auccacucuc cu                                                22


<210> 3060
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3060
uccuccucua ccucauccca gu                                                22


<210> 3061
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3061
acugggauga gguagaggag ga                                                22


<210> 3062
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3062
ugagggguuu ggaaugggau gg                                                22


<210> 3063
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3063
ccaucccauu ccaaaccccu ca                                                22


<210> 3064
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3064
auccaguucu cugagggggc u                                                 21


<210> 3065
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3065
agcccccuca gagaacugga u                                                 21


<210> 3066
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3066
aaccccuaag gcaacuggau gg                                                22


<210> 3067
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3067
ccauccaguu gccuuagggg uu                                                22


<210> 3068
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3068
ucauccucgu cucccuccca g                                                 21


<210> 3069
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3069
cugggaggga gacgaggaug a                                                 21


<210> 3070
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3070
agggaagggg acgaggguug gg                                                22


<210> 3071
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3071
cccaacccuc guccccuucc cu                                                22


<210> 3072
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3072
aagaagagac ugagucaucg aau                                               23


<210> 3073
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3073
auucgaugac ucagucucuu cuu                                               23


<210> 3074
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3074
caauggcaca aacucauucu uga                                               23


<210> 3075
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3075
ucaagaauga guuugugcca uug                                               23


<210> 3076
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3076
acugaauccu cuuuuccuca g                                                 21


<210> 3077
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3077
cugaggaaaa gaggauucag u                                                 21


<210> 3078
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3078
ugggaugagg gauugaagug ga                                                22


<210> 3079
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3079
uccacuucaa ucccucaucc ca                                                22


<210> 3080
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3080
caggccauau ugugcugccu ca                                                22


<210> 3081
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3081
ugaggcagca caauauggcc ug                                                22


<210> 3082
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3082
uagcagcaca uaaugguuug ug                                                22


<210> 3083
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3083
cacaaaccau uaugugcugc ua                                                22


<210> 3084
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3084
cgaaucauua uuugcugcuc ua                                                22


<210> 3085
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3085
uagagcagca aauaaugauu cg                                                22


<210> 3086
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3086
uagcagcaca ucaugguuua ca                                                22


<210> 3087
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3087
uguaaaccau gaugugcugc ua                                                22


<210> 3088
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3088
ccaauauuac ugugcugcuu ua                                                22


<210> 3089
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3089
uaaagcagca caguaauauu gg                                                22


<210> 3090
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3090
cuagguaugg ucccagggau cc                                                22


<210> 3091
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3091
ggaucccugg gaccauaccu ag                                                22


<210> 3092
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3092
guguguggaa augcuucugc                                                   20


<210> 3093
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3093
gcagaagcau uuccacacac                                                   20


<210> 3094
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3094
gugugcggaa augcuucugc ua                                                22


<210> 3095
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3095
uagcagaagc auuuccgcac ac                                                22


<210> 3096
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3096
agcagcauug uacagggcua uca                                               23


<210> 3097
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3097
ugauagcccu guacaaugcu gcu                                               23


<210> 3098
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3098
aacuggcccu caaagucccg cu                                                22


<210> 3099
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3099
agcgggacuu ugagggccag uu                                                22


<210> 3100
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3100
cgggguuuug agggcgagau ga                                                22


<210> 3101
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3101
ucaucucgcc cucaaaaccc cg                                                22


<210> 3102
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3102
gcagggacag caaaggggug c                                                 21


<210> 3103
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3103
gcaccccuuu gcugucccug c                                                 21


<210> 3104
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3104
uucccuuugu cauccuucgc cu                                                22


<210> 3105
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3105
aggcgaagga ugacaaaggg aa                                                22


<210> 3106
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3106
auggccaaaa cugcaguuau uuu                                               23


<210> 3107
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3107
aaaauaacug caguuuuggc cau                                               23


<210> 3108
<211> 25
<212> RNA
<213> Homo sapiens

<400> 3108
aaaaaccaca auuacuuuug cacca                                             25


<210> 3109
<211> 25
<212> RNA
<213> Homo sapiens

<400> 3109
uggugcaaaa guaauugugg uuuuu                                             25


<210> 3110
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3110
caaaagugau cgugguuuuu g                                                 21


<210> 3111
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3111
caaaaaccac gaucacuuuu g                                                 21


<210> 3112
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3112
caaagacugc aauuacuuuu gcg                                               23


<210> 3113
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3113
cgcaaaagua auugcagucu uug                                               23


<210> 3114
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3114
aaaaguaacu gcgguuuuug ccu                                               23


<210> 3115
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3115
aggcaaaaac cgcaguuacu uuu                                               23


<210> 3116
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3116
ugccuggaac auaguaggga cu                                                22


<210> 3117
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3117
agucccuacu auguuccagg ca                                                22


<210> 3118
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3118
auaggacuca uauagugcca g                                                 21


<210> 3119
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3119
cuggcacuau augaguccua u                                                 21


<210> 3120
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3120
agacacuaua cgagucauau                                                   20


<210> 3121
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3121
auaugacucg uauagugucu                                                   20


<210> 3122
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3122
ugugacugca uuaugaaaau ucu                                               23


<210> 3123
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3123
agaauuuuca uaaugcaguc aca                                               23


<210> 3124
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3124
uggcuuuuaa cuuugauggc                                                   20


<210> 3125
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3125
gccaucaaag uuaaaagcca                                                   20


<210> 3126
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3126
cacagcaagu guagacaggc a                                                 21


<210> 3127
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3127
ugccugucua cacuugcugu g                                                 21


<210> 3128
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3128
ccugucugug ccugcuguac a                                                 21


<210> 3129
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3129
uguacagcag gcacagacag g                                                 21


<210> 3130
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3130
uaaauagagu aggcaaagga ca                                                22


<210> 3131
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3131
uguccuuugc cuacucuauu ua                                                22


<210> 3132
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3132
uccuuugccu auucuauuua ag                                                22


<210> 3133
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3133
cuuaaauaga auaggcaaag ga                                                22


<210> 3134
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3134
guugggacaa gaggacgguc uu                                                22


<210> 3135
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3135
aagaccgucc ucuuguccca ac                                                22


<210> 3136
<211> 17
<212> RNA
<213> Homo sapiens

<400> 3136
cagagaauug uuuaauc                                                      17


<210> 3137
<211> 17
<212> RNA
<213> Homo sapiens

<400> 3137
gauuaaacaa uucucug                                                      17


<210> 3138
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3138
uagaggaagc uguggagaga                                                   20


<210> 3139
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3139
ucucuccaca gcuuccucua                                                   20


<210> 3140
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3140
uccccuucug caggccugcu gg                                                22


<210> 3141
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3141
ccagcaggcc ugcagaaggg ga                                                22


<210> 3142
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3142
aucagggcuu guggaauggg aag                                               23


<210> 3143
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3143
cuucccauuc cacaagcccu gau                                               23


<210> 3144
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3144
ucuggcaagu aaaaaacucu cau                                               23


<210> 3145
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3145
augagaguuu uuuacuugcc aga                                               23


<210> 3146
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3146
ucgaggacug guggaagggc cuu                                               23


<210> 3147
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3147
aaggcccuuc caccaguccu cga                                               23


<210> 3148
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3148
uggguagaga aggagcucag agga                                              24


<210> 3149
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3149
uccucugagc uccuucucua ccca                                              24


<210> 3150
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3150
uaaagaacuc uuaaaaccca au                                                22


<210> 3151
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3151
auuggguuuu aagaguucuu ua                                                22


<210> 3152
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3152
ugauggauaa aagacuacau auu                                               23


<210> 3153
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3153
aauauguagu cuuuuaucca uca                                               23


<210> 3154
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3154
ugccuaggcu gagacugcag ug                                                22


<210> 3155
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3155
cacugcaguc ucagccuagg ca                                                22


<210> 3156
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3156
uggcccaacc uauucaguua gu                                                22


<210> 3157
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3157
acuaacugaa uagguugggc ca                                                22


<210> 3158
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3158
cugacugaau agguaggguc auu                                               23


<210> 3159
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3159
aaugacccua ccuauucagu cag                                               23


<210> 3160
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3160
ucuguagccu gggagcaaug gggu                                              24


<210> 3161
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3161
accccauugc ucccaggcua caga                                              24


<210> 3162
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3162
uaggagcuca acagaugccu guu                                               23


<210> 3163
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3163
aacaggcauc uguugagcuc cua                                               23


<210> 3164
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3164
gagggcgggu ggaggagga                                                    19


<210> 3165
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3165
uccuccucca cccgcccuc                                                    19


<210> 3166
<211> 25
<212> RNA
<213> Homo sapiens

<400> 3166
auaacauugu aaagcgcuuc uuucg                                             25


<210> 3167
<211> 25
<212> RNA
<213> Homo sapiens

<400> 3167
cgaaagaagc gcuuuacaau guuau                                             25


<210> 3168
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3168
agauauuuug aguguuugga auug                                              24


<210> 3169
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3169
caauuccaaa cacucaaaau aucu                                              24


<210> 3170
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3170
aacuccaaac acucaaaacu ca                                                22


<210> 3171
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3171
ugaguuuuga guguuuggag uu                                                22


<210> 3172
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3172
caugcuagga uagaaagaau gg                                                22


<210> 3173
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3173
ccauucuuuc uauccuagca ug                                                22


<210> 3174
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3174
gguugggcag ugaggagggu guga                                              24


<210> 3175
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3175
ucacacccuc cucacugccc aacc                                              24


<210> 3176
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3176
uggaaaaaac uggugugugc uu                                                22


<210> 3177
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3177
aagcacacac caguuuuuuc ca                                                22


<210> 3178
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3178
cuggggagau ccucgagguu gg                                                22


<210> 3179
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3179
ccaaccucga ggaucucccc ag                                                22


<210> 3180
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3180
caaccucgac gaucuccuca gc                                                22


<210> 3181
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3181
gcugaggaga ucgucgaggu ug                                                22


<210> 3182
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3182
ugaggagauc gucgagguug g                                                 21


<210> 3183
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3183
ccaaccucga cgaucuccuc a                                                 21


<210> 3184
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3184
caaccucgag gaucucccca gc                                                22


<210> 3185
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3185
gcuggggaga uccucgaggu ug                                                22


<210> 3186
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3186
gguggggcaa ugggaucagg u                                                 21


<210> 3187
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3187
accugauccc auugccccac c                                                 21


<210> 3188
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3188
ggggaaagcg aguagggaca uuu                                               23


<210> 3189
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3189
aaaugucccu acucgcuuuc ccc                                               23


<210> 3190
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3190
cagaagggga guugggagca ga                                                22


<210> 3191
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3191
ucugcuccca acuccccuuc ug                                                22


<210> 3192
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3192
ccaggcucug cagugggaac u                                                 21


<210> 3193
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3193
aguucccacu gcagagccug g                                                 21


<210> 3194
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3194
cucccacuuc cagaucuuuc u                                                 21


<210> 3195
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3195
agaaagaucu ggaaguggga g                                                 21


<210> 3196
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3196
aaagaucugg aagugggaga ca                                                22


<210> 3197
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3197
ugucucccac uuccagaucu uu                                                22


<210> 3198
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3198
cugcccuagu cuagcugaag cu                                                22


<210> 3199
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3199
agcuucagcu agacuagggc ag                                                22


<210> 3200
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3200
uucagccagg cuagugcagu cu                                                22


<210> 3201
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3201
agacugcacu agccuggcug aa                                                22


<210> 3202
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3202
uaggauuaca agugucggcc ac                                                22


<210> 3203
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3203
guggccgaca cuuguaaucc ua                                                22


<210> 3204
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3204
agagcugaga cuagaaagcc ca                                                22


<210> 3205
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3205
ugggcuuucu agucucagcu cu                                                22


<210> 3206
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3206
ggcuuucuag ucucagcucu cc                                                22


<210> 3207
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3207
ggagagcuga gacuagaaag cc                                                22


<210> 3208
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3208
cugauaagaa cagaggccca gau                                               23


<210> 3209
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3209
aucugggccu cuguucuuau cag                                               23


<210> 3210
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3210
ucccuacccc uccacucccc a                                                 21


<210> 3211
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3211
uggggagugg agggguaggg a                                                 21


<210> 3212
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3212
uuagggagua gaaggguggg gag                                               23


<210> 3213
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3213
cuccccaccc uucuacuccc uaa                                               23


<210> 3214
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3214
uauaaaauga gggcaguaag ac                                                22


<210> 3215
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3215
gucuuacugc ccucauuuua ua                                                22


<210> 3216
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3216
ugugacuuua agggaaaugg cg                                                22


<210> 3217
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3217
cgccauuucc cuuaaaguca ca                                                22


<210> 3218
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3218
agguggaugc aaugugaccu ca                                                22


<210> 3219
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3219
ugaggucaca uugcauccac cu                                                22


<210> 3220
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3220
cgcagacaau gccuacuggc cua                                               23


<210> 3221
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3221
uaggccagua ggcauugucu gcg                                               23


<210> 3222
<211> 17
<212> RNA
<213> Homo sapiens

<400> 3222
gaguucuaca gucagac                                                      17


<210> 3223
<211> 17
<212> RNA
<213> Homo sapiens

<400> 3223
gucugacugu agaacuc                                                      17


<210> 3224
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3224
uaggacugug cuuggcacau ag                                                22


<210> 3225
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3225
cuaugugcca agcacagucc ua                                                22


<210> 3226
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3226
cugggguucu gagacagaca gu                                                22


<210> 3227
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3227
acugucuguc ucagaacccc ag                                                22


<210> 3228
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3228
aaaggaggaa auaggcaggc ca                                                22


<210> 3229
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3229
uggccugccu auuuccuccu uu                                                22


<210> 3230
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3230
ugcccugccu guuuucuccu uu                                                22


<210> 3231
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3231
aaaggagaaa acaggcaggg ca                                                22


<210> 3232
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3232
uagugaguua gagaugcaga gcc                                               23


<210> 3233
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3233
ggcucugcau cucuaacuca cua                                               23


<210> 3234
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3234
acuggccugg gacuaccgg                                                    19


<210> 3235
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3235
ccgguagucc caggccagu                                                    19


<210> 3236
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3236
ugcacggcac uggggacacg u                                                 21


<210> 3237
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3237
acgugucccc agugccgugc a                                                 21


<210> 3238
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3238
uguguacaca cgugccaggc gcu                                               23


<210> 3239
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3239
agcgccuggc acguguguac aca                                               23


<210> 3240
<211> 17
<212> RNA
<213> Homo sapiens

<400> 3240
ggggcgcggc cggaucg                                                      17


<210> 3241
<211> 17
<212> RNA
<213> Homo sapiens

<400> 3241
cgauccggcc gcgcccc                                                      17


<210> 3242
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3242
agaaggggug aaauuuaaac gu                                                22


<210> 3243
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3243
acguuuaaau uucaccccuu cu                                                22


<210> 3244
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3244
aucgggcccu cggcgccgg                                                    19


<210> 3245
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3245
ccggcgccga gggcccgau                                                    19


<210> 3246
<211> 17
<212> RNA
<213> Homo sapiens

<400> 3246
gcuucuguag uguaguc                                                      17


<210> 3247
<211> 17
<212> RNA
<213> Homo sapiens

<400> 3247
gacuacacua cagaagc                                                      17


<210> 3248
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3248
gccucucucg gagucgcucg ga                                                22


<210> 3249
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3249
uccgagcgac uccgagagag gc                                                22


<210> 3250
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3250
aaagucucgc ucucugcccc uca                                               23


<210> 3251
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3251
ugaggggcag agagcgagac uuu                                               23


<210> 3252
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3252
ugaggggccu cagaccgagc uuuu                                              24


<210> 3253
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3253
aaaagcucgg ucugaggccc cuca                                              24


<210> 3254
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3254
agaagaaggc ggucggucug cgg                                               23


<210> 3255
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3255
ccgcagaccg accgccuucu ucu                                               23


<210> 3256
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3256
uuggccaugg ggcugcgcgg                                                   20


<210> 3257
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3257
ccgcgcagcc ccauggccaa                                                   20


<210> 3258
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3258
ccugggcagc guguggcuga agg                                               23


<210> 3259
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3259
ccuucagcca cacgcugccc agg                                               23


<210> 3260
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3260
agaggcuuug ugcggauacg ggg                                               23


<210> 3261
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3261
ccccguaucc gcacaaagcc ucu                                               23


<210> 3262
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3262
cccuuggguc ugauggggua g                                                 21


<210> 3263
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3263
cuaccccauc agacccaagg g                                                 21


<210> 3264
<211> 25
<212> RNA
<213> Homo sapiens

<400> 3264
ugccccaucu gugcccuggg uagga                                             25


<210> 3265
<211> 25
<212> RNA
<213> Homo sapiens

<400> 3265
uccuacccag ggcacagaug gggca                                             25


<210> 3266
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3266
uguggaaggu agacggccag aga                                               23


<210> 3267
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3267
ucucuggccg ucuaccuucc aca                                               23


<210> 3268
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3268
ucuggccagc uacgucccca                                                   20


<210> 3269
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3269
uggggacgua gcuggccaga                                                   20


<210> 3270
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3270
uggggacgua gcuggccaga cag                                               23


<210> 3271
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3271
cugucuggcc agcuacgucc cca                                               23


<210> 3272
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3272
cucucuggcc gucuaccuuc ca                                                22


<210> 3273
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3273
uggaagguag acggccagag ag                                                22


<210> 3274
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3274
ucugggaggu uguagcagug gaa                                               23


<210> 3275
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3275
uuccacugcu acaaccuccc aga                                               23


<210> 3276
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3276
uccugcguag gaucugagga gu                                                22


<210> 3277
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3277
acuccucaga uccuacgcag ga                                                22


<210> 3278
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3278
agcucugcug cucacuggca gu                                                22


<210> 3279
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3279
acugccagug agcagcagag cu                                                22


<210> 3280
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3280
ggccagccac caggagggcu g                                                 21


<210> 3281
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3281
cagcccuccu gguggcuggc c                                                 21


<210> 3282
<211> 17
<212> RNA
<213> Homo sapiens

<400> 3282
cgcgccgggc ccggguu                                                      17


<210> 3283
<211> 17
<212> RNA
<213> Homo sapiens

<400> 3283
aacccgggcc cggcgcg                                                      17


<210> 3284
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3284
ggaggcgcag gcucggaaag gcg                                               23


<210> 3285
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3285
cgccuuuccg agccugcgcc ucc                                               23


<210> 3286
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3286
guggaguccu ggggaaugga ga                                                22


<210> 3287
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3287
ucuccauucc ccaggacucc ac                                                22


<210> 3288
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3288
agggacugcc uuaggagaaa guu                                               23


<210> 3289
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3289
aacuuucucc uaaggcaguc ccu                                               23


<210> 3290
<211> 17
<212> RNA
<213> Homo sapiens

<400> 3290
gggauaugaa gaaaaau                                                      17


<210> 3291
<211> 17
<212> RNA
<213> Homo sapiens

<400> 3291
auuuuucuuc auauccc                                                      17


<210> 3292
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3292
uggaagggag aagagcuuua au                                                22


<210> 3293
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3293
auuaaagcuc uucucccuuc ca                                                22


<210> 3294
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3294
acuuuccuca cucccgugaa gu                                                22


<210> 3295
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3295
acuucacggg agugaggaaa gu                                                22


<210> 3296
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3296
uucgcgggcg aaggcaaagu c                                                 21


<210> 3297
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3297
gacuuugccu ucgcccgcga a                                                 21


<210> 3298
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3298
caucuggcau ccgucacaca ga                                                22


<210> 3299
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3299
ucugugugac ggaugccaga ug                                                22


<210> 3300
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3300
ugagggacag augccagaag ca                                                22


<210> 3301
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3301
ugcuucuggc aucugucccu ca                                                22


<210> 3302
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3302
aaacuaaucu cuacacugcu gc                                                22


<210> 3303
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3303
gcagcagugu agagauuagu uu                                                22


<210> 3304
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3304
gcaguagugu agagauuggu uu                                                22


<210> 3305
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3305
aaaccaaucu cuacacuacu gc                                                22


<210> 3306
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3306
gcugcaccgg agacugggua a                                                 21


<210> 3307
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3307
uuacccaguc uccggugcag c                                                 21


<210> 3308
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3308
uacccagucu ccggugcagc c                                                 21


<210> 3309
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3309
ggcugcaccg gagacugggu a                                                 21


<210> 3310
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3310
uguggacagu gagguagagg gagu                                              24


<210> 3311
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3311
acucccucua ccucacuguc caca                                              24


<210> 3312
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3312
agcuuuuggg aauucaggua gu                                                22


<210> 3313
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3313
acuaccugaa uucccaaaag cu                                                22


<210> 3314
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3314
accugaauua ccaaaagcuu u                                                 21


<210> 3315
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3315
aaagcuuuug guaauucagg u                                                 21


<210> 3316
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3316
auauaccugu ucggucucuu ua                                                22


<210> 3317
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3317
uaaagagacc gaacagguau au                                                22


<210> 3318
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3318
aggggaccaa agagauauau ag                                                22


<210> 3319
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3319
cuauauaucu cuuugguccc cu                                                22


<210> 3320
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3320
uuuguaugga uaugugugug uau                                               23


<210> 3321
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3321
auacacacac auauccauac aaa                                               23


<210> 3322
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3322
uguguuagaa uaggggcaau aa                                                22


<210> 3323
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3323
uuauugcccc uauucuaaca ca                                                22


<210> 3324
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3324
auugccucug uucuaacaca ag                                                22


<210> 3325
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3325
cuuguguuag aacagaggca au                                                22


<210> 3326
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3326
aagggcuucc ucucugcagg ac                                                22


<210> 3327
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3327
guccugcaga gaggaagccc uu                                                22


<210> 3328
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3328
ccugcagaga ggaagcccuu c                                                 21


<210> 3329
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3329
gaagggcuuc cucucugcag g                                                 21


<210> 3330
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3330
aggauuucag aaauacuggu gu                                                22


<210> 3331
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3331
acaccaguau uucugaaauc cu                                                22


<210> 3332
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3332
agauguaugg aaucuguaua uauc                                              24


<210> 3333
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3333
gauauauaca gauuccauac aucu                                              24


<210> 3334
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3334
cggggagaga acgcagugac gu                                                22


<210> 3335
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3335
acgucacugc guucucuccc cg                                                22


<210> 3336
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3336
uggggcggag cuuccggag                                                    19


<210> 3337
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3337
cuccggaagc uccgcccca                                                    19


<210> 3338
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3338
ucacgcggag agauggcuuu g                                                 21


<210> 3339
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3339
caaagccauc ucuccgcgug a                                                 21


<210> 3340
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3340
caggcgucug ucuacguggc uu                                                22


<210> 3341
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3341
aagccacgua gacagacgcc ug                                                22


<210> 3342
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3342
caccuugcgc uacucagguc ug                                                22


<210> 3343
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3343
cagaccugag uagcgcaagg ug                                                22


<210> 3344
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3344
aaucugagaa ggcgcacaag gu                                                22


<210> 3345
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3345
accuugugcg ccuucucaga uu                                                22


<210> 3346
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3346
aaggccuuuc ugaaccuuca ga                                                22


<210> 3347
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3347
ucugaagguu cagaaaggcc uu                                                22


<210> 3348
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3348
gugacaucac auauacggca gc                                                22


<210> 3349
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3349
gcugccguau augugauguc ac                                                22


<210> 3350
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3350
ucagaacaaa ugccgguucc caga                                              24


<210> 3351
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3351
ucugggaacc ggcauuuguu cuga                                              24


<210> 3352
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3352
ugagaaccac gucugcucug ag                                                22


<210> 3353
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3353
cucagagcag acgugguucu ca                                                22


<210> 3354
<211> 17
<212> RNA
<213> Homo sapiens

<400> 3354
ucauauugcu ucuuucu                                                      17


<210> 3355
<211> 17
<212> RNA
<213> Homo sapiens

<400> 3355
agaaagaagc aauauga                                                      17


<210> 3356
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3356
ugugacagau ugauaacuga aa                                                22


<210> 3357
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3357
uuucaguuau caaucuguca ca                                                22


<210> 3358
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3358
uggaguccag gaaucugcau uuu                                               23


<210> 3359
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3359
aaaaugcaga uuccuggacu cca                                               23


<210> 3360
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3360
aagcccuuac cccaaaaagu au                                                22


<210> 3361
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3361
auacuuuuug ggguaagggc uu                                                22


<210> 3362
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3362
aagcccuuac cccaaaaagc au                                                22


<210> 3363
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3363
augcuuuuug ggguaagggc uu                                                22


<210> 3364
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3364
uggaauguaa ggaagugugu gg                                                22


<210> 3365
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3365
ccacacacuu ccuuacauuc ca                                                22


<210> 3366
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3366
cuuaucagau uguauuguaa uu                                                22


<210> 3367
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3367
aauuacaaua caaucugaua ag                                                22


<210> 3368
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3368
uuauaauaca accugauaag ug                                                22


<210> 3369
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3369
cacuuaucag guuguauuau aa                                                22


<210> 3370
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3370
cuuagcaggu uguauuauca uu                                                22


<210> 3371
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3371
aaugauaaua caaccugcua ag                                                22


<210> 3372
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3372
auauaauaca accugcuaag ug                                                22


<210> 3373
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3373
cacuuagcag guuguauuau au                                                22


<210> 3374
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3374
cacuuagcag guuguauuau au                                                22


<210> 3375
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3375
auauaauaca accugcuaag ug                                                22


<210> 3376
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3376
auaauacaac cugcuaagug cu                                                22


<210> 3377
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3377
agcacuuagc agguuguauu au                                                22


<210> 3378
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3378
uuuggucccc uucaaccagc ug                                                22


<210> 3379
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3379
cagcugguug aaggggacca aa                                                22


<210> 3380
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3380
uuuggucccc uucaaccagc ua                                                22


<210> 3381
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3381
uagcugguug aaggggacca aa                                                22


<210> 3382
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3382
uguaaacauc cuugacugga ag                                                22


<210> 3383
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3383
cuuccaguca aggauguuua ca                                                22


<210> 3384
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3384
ugucaguuug ucaaauaccc ca                                                22


<210> 3385
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3385
ugggguauuu gacaaacuga ca                                                22


<210> 3386
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3386
cguguauuug acaagcugag uu                                                22


<210> 3387
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3387
aacucagcuu gucaaauaca cg                                                22


<210> 3388
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3388
uucacagugg cuaaguuccg c                                                 21


<210> 3389
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3389
gcggaacuua gccacuguga a                                                 21


<210> 3390
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3390
agggcuuagc ugcuugugag ca                                                22


<210> 3391
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3391
ugcucacaag cagcuaagcc cu                                                22


<210> 3392
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3392
aucacauugc cagggauuac c                                                 21


<210> 3393
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3393
gguaaucccu ggcaauguga u                                                 21


<210> 3394
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3394
uggguuccug gcaugcugau uu                                                22


<210> 3395
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3395
aaaucagcau gccaggaacc ca                                                22


<210> 3396
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3396
cuuucagucg gauguuuaca gc                                                22


<210> 3397
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3397
gcuguaaaca uccgacugaa ag                                                22


<210> 3398
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3398
ugccuacuga gcugauauca gu                                                22


<210> 3399
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3399
acugauauca gcucaguagg ca                                                22


<210> 3400
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3400
ugccuacuga gcugaaacac ag                                                22


<210> 3401
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3401
cuguguuuca gcucaguagg ca                                                22


<210> 3402
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3402
uggcucaguu cagcaggaac ag                                                22


<210> 3403
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3403
cuguuccugc ugaacugagc ca                                                22


<210> 3404
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3404
uucacagugg cuaaguucug c                                                 21


<210> 3405
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3405
gcagaacuua gccacuguga a                                                 21


<210> 3406
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3406
agagcuuagc ugauugguga ac                                                22


<210> 3407
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3407
guucaccaau cagcuaagcu cu                                                22


<210> 3408
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3408
uguaguguuu ccuacuuuau gga                                               23


<210> 3409
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3409
uccauaaagu aggaaacacu aca                                               23


<210> 3410
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3410
cauaaaguag aaagcacuac u                                                 21


<210> 3411
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3411
aguagugcuu ucuacuuuau g                                                 21


<210> 3412
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3412
ugaaggucua cugugugcca gg                                                22


<210> 3413
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3413
ccuggcacac aguagaccuu ca                                                22


<210> 3414
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3414
uuguacaugg uaggcuuuca uu                                                22


<210> 3415
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3415
aaugaaagcc uaccauguac aa                                                22


<210> 3416
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3416
cuggauggcu ccuccauguc u                                                 21


<210> 3417
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3417
agacauggag gagccaucca g                                                 21


<210> 3418
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3418
ucuuggagua ggucauuggg ugg                                               23


<210> 3419
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3419
ccacccaaug accuacucca aga                                               23


<210> 3420
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3420
cucaucugca aagaaguaag ug                                                22


<210> 3421
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3421
cacuuacuuc uuugcagaug ag                                                22


<210> 3422
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3422
aacuguuugc agaggaaacu ga                                                22


<210> 3423
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3423
ucaguuuccu cugcaaacag uu                                                22


<210> 3424
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3424
cuugguucag ggaggguccc ca                                                22


<210> 3425
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3425
uggggacccu cccugaacca ag                                                22


<210> 3426
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3426
aggaccuucc cugaaccaag ga                                                22


<210> 3427
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3427
uccuugguuc agggaagguc cu                                                22


<210> 3428
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3428
accuccugug ugcauggauu a                                                 21


<210> 3429
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3429
uaauccaugc acacaggagg u                                                 21


<210> 3430
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3430
uacccauugc auaucggagu ug                                                22


<210> 3431
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3431
caacuccgau augcaauggg ua                                                22


<210> 3432
<211> 18
<212> RNA
<213> Homo sapiens

<400> 3432
aaagcugggu ugagaagg                                                     18


<210> 3433
<211> 18
<212> RNA
<213> Homo sapiens

<400> 3433
ccuucucaac ccagcuuu                                                     18


<210> 3434
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3434
gguauccguu uggggauggu                                                   20


<210> 3435
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3435
accaucccca aacggauacc                                                   20


<210> 3436
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3436
gaaggcagca gugcuccccu gu                                                22


<210> 3437
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3437
acaggggagc acugcugccu uc                                                22


<210> 3438
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3438
ucagugcauc acagaacuuu gu                                                22


<210> 3439
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3439
acaaaguucu gugaugcacu ga                                                22


<210> 3440
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3440
aaguucuguu auacacucag gc                                                22


<210> 3441
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3441
gccugagugu auaacagaac uu                                                22


<210> 3442
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3442
cuggcccucu cugcccuucc gu                                                22


<210> 3443
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3443
acggaagggc agagagggcc ag                                                22


<210> 3444
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3444
cuagacugaa gcuccuugag g                                                 21


<210> 3445
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3445
ccucaaggag cuucagucua g                                                 21


<210> 3446
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3446
ucgaggagcu cacagucuag u                                                 21


<210> 3447
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3447
acuagacugu gagcuccucg a                                                 21


<210> 3448
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3448
cacauuacac ggucgaccuc u                                                 21


<210> 3449
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3449
agaggucgac cguguaaugu g                                                 21


<210> 3450
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3450
aggugguccg uggcgcguuc gc                                                22


<210> 3451
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3451
gcgaacgcgc cacggaccac cu                                                22


<210> 3452
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3452
cgcauccccu agggcauugg ugu                                               23


<210> 3453
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3453
acaccaaugc ccuaggggau gcg                                               23


<210> 3454
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3454
ccucugggcc cuuccuccag                                                   20


<210> 3455
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3455
cuggaggaag ggcccagagg                                                   20


<210> 3456
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3456
ccuaguaggu guccaguaag ugu                                               23


<210> 3457
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3457
acacuuacug gacaccuacu agg                                               23


<210> 3458
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3458
acggugcugg auguggccuu u                                                 21


<210> 3459
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3459
aaaggccaca uccagcaccg u                                                 21


<210> 3460
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3460
ucagcaccag gauauuguug gag                                               23


<210> 3461
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3461
cuccaacaau auccuggugc uga                                               23


<210> 3462
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3462
ucaacaaaau cacugaugcu gga                                               23


<210> 3463
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3463
uccagcauca gugauuuugu uga                                               23


<210> 3464
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3464
aacaauaucc uggugcugag ug                                                22


<210> 3465
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3465
cacucagcac caggauauug uu                                                22


<210> 3466
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3466
ggcagguucu cacccucucu agg                                               23


<210> 3467
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3467
ccuagagagg gugagaaccu gcc                                               23


<210> 3468
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3468
gacacgggcg acagcugcgg ccc                                               23


<210> 3469
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3469
gggccgcagc ugucgcccgu guc                                               23


<210> 3470
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3470
auguaugugu gcaugugcau g                                                 21


<210> 3471
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3471
caugcacaug cacacauaca u                                                 21


<210> 3472
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3472
uauacaaggg cagacucucu cu                                                22


<210> 3473
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3473
agagagaguc ugcccuugua ua                                                22


<210> 3474
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3474
ggcggcggcg gaggcggggg                                                   20


<210> 3475
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3475
cccccgccuc cgccgccgcc                                                   20


<210> 3476
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3476
gcaggugcuc acuuguccuc cu                                                22


<210> 3477
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3477
aggaggacaa gugagcaccu gc                                                22


<210> 3478
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3478
ggggccuggc ggugggcgg                                                    19


<210> 3479
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3479
ccgcccaccg ccaggcccc                                                    19


<210> 3480
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3480
gcccaaaggu gaauuuuuug gg                                                22


<210> 3481
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3481
cccaaaaaau ucaccuuugg gc                                                22


<210> 3482
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3482
caaagaauuc uccuuuuggg cu                                                22


<210> 3483
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3483
agcccaaaag gagaauucuu ug                                                22


<210> 3484
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3484
cugcaaugua agcacuucuu ac                                                22


<210> 3485
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3485
guaagaagug cuuacauugc ag                                                22


<210> 3486
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3486
aaaagugcuu acagugcagg uag                                               23


<210> 3487
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3487
cuaccugcac uguaagcacu uuu                                               23


<210> 3488
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3488
acuguaguau gggcacuucc ag                                                22


<210> 3489
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3489
cuggaagugc ccauacuaca gu                                                22


<210> 3490
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3490
caaagugcuc auagugcagg uag                                               23


<210> 3491
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3491
cuaccugcac uaugagcacu uug                                               23


<210> 3492
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3492
gggguauugu uuccgcugcc agg                                               23


<210> 3493
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3493
ccuggcagcg gaaacaauac ccc                                               23


<210> 3494
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3494
uagcagcggg aacaguucug cag                                               23


<210> 3495
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3495
cugcagaacu guucccgcug cua                                               23


<210> 3496
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3496
cgagccucaa gcaagggacu u                                                 21


<210> 3497
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3497
aagucccuug cuugaggcuc g                                                 21


<210> 3498
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3498
uagucccuuc cuugaagcgg uc                                                22


<210> 3499
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3499
gaccgcuuca aggaagggac ua                                                22


<210> 3500
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3500
acuggacuug gagucagaag g                                                 21


<210> 3501
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3501
ccuucugacu ccaaguccag u                                                 21


<210> 3502
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3502
cuccugacuc cagguccugu gu                                                22


<210> 3503
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3503
acacaggacc uggagucagg ag                                                22


<210> 3504
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3504
uuuguucguu cggcucgcgu ga                                                22


<210> 3505
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3505
ucacgcgagc cgaacgaaca aa                                                22


<210> 3506
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3506
acggauguuu gagcaugugc ua                                                22


<210> 3507
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3507
uagcacaugc ucaaacaucc gu                                                22


<210> 3508
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3508
ucaaaugcuc agacuccugu ggu                                               23


<210> 3509
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3509
accacaggag ucugagcauu uga                                               23


<210> 3510
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3510
cggcaacaag aaacugccug ag                                                22


<210> 3511
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3511
cucaggcagu uucuuguugc cg                                                22


<210> 3512
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3512
uagguaguuu cauguuguug gg                                                22


<210> 3513
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3513
cccaacaaca ugaaacuacc ua                                                22


<210> 3514
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3514
caauguuucc acagugcauc ac                                                22


<210> 3515
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3515
gugaugcacu guggaaacau ug                                                22


<210> 3516
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3516
gugcauugua guugcauugc a                                                 21


<210> 3517
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3517
ugcaaugcaa cuacaaugca c                                                 21


<210> 3518
<211> 18
<212> RNA
<213> Homo sapiens

<400> 3518
aucccaccuc ugccacca                                                     18


<210> 3519
<211> 18
<212> RNA
<213> Homo sapiens

<400> 3519
ugguggcaga ggugggau                                                     18


<210> 3520
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3520
aucccaccac ugccaccau                                                    19


<210> 3521
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3521
augguggcag uggugggau                                                    19


<210> 3522
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3522
accuuccucu ccaugggucu uu                                                22


<210> 3523
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3523
aaagacccau ggagaggaag gu                                                22


<210> 3524
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3524
aaagacccau ugaggagaag gu                                                22


<210> 3525
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3525
accuucuccu caaugggucu uu                                                22


<210> 3526
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3526
aauguagaga uugaucaaaa u                                                 21


<210> 3527
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3527
auuuugauca aucucuacau u                                                 21


<210> 3528
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3528
acggaauaug uauacggaau aua                                               23


<210> 3529
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3529
uauauuccgu auacauauuc cgu                                               23


<210> 3530
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3530
agagcucaca gcuguccuuc ucua                                              24


<210> 3531
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3531
uagagaagga cagcugugag cucu                                              24


<210> 3532
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3532
aucaaauaag gacuagucug ca                                                22


<210> 3533
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3533
ugcagacuag uccuuauuug au                                                22


<210> 3534
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3534
augagacuca uguaaaacau cuu                                               23


<210> 3535
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3535
aagauguuuu acaugagucu cau                                               23


<210> 3536
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3536
auggaaugua uauacggaau a                                                 21


<210> 3537
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3537
uauuccguau auacauucca u                                                 21


<210> 3538
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3538
auuguagaac cuaagauugg cc                                                22


<210> 3539
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3539
ggccaaucuu agguucuaca au                                                22


<210> 3540
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3540
caucucuaag gaacuccccc aa                                                22


<210> 3541
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3541
uugggggagu uccuuagaga ug                                                22


<210> 3542
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3542
uauggggcuu cuguagagau uuc                                               23


<210> 3543
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3543
gaaaucucua cagaagcccc aua                                               23


<210> 3544
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3544
ccguguuucc cccacgcuuu                                                   20


<210> 3545
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3545
aaagcguggg ggaaacacgg                                                   20


<210> 3546
<211> 15
<212> RNA
<213> Homo sapiens

<400> 3546
aggagauccu ggguu                                                        15


<210> 3547
<211> 15
<212> RNA
<213> Homo sapiens

<400> 3547
aacccaggau cuccu                                                        15


<210> 3548
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3548
cucgugggcu cuggccacgg cc                                                22


<210> 3549
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3549
ggccguggcc agagcccacg ag                                                22


<210> 3550
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3550
caguggccag agcccugcag ug                                                22


<210> 3551
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3551
cacugcaggg cucuggccac ug                                                22


<210> 3552
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3552
cugcagaguu uguacggacc gg                                                22


<210> 3553
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3553
ccgguccgua caaacucugc ag                                                22


<210> 3554
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3554
uccguacaaa cucugcugug                                                   20


<210> 3555
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3555
cacagcagag uuuguacgga                                                   20


<210> 3556
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3556
cuucccccca guaaucuuca uc                                                22


<210> 3557
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3557
gaugaagauu acugggggga ag                                                22


<210> 3558
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3558
ugaggauaug gcagggaagg gga                                               23


<210> 3559
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3559
uccccuuccc ugccauaucc uca                                               23


<210> 3560
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3560
uuuugcauga cccugggagu agg                                               23


<210> 3561
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3561
ccuacuccca gggucaugca aaa                                               23


<210> 3562
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3562
gacucacuca caggauugug ca                                                22


<210> 3563
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3563
ugcacaaucc ugugagugag uc                                                22


<210> 3564
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3564
acacagugcu ucauccacua cu                                                22


<210> 3565
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3565
aguaguggau gaagcacugu gu                                                22


<210> 3566
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3566
uaguggauga ugcacucugu gc                                                22


<210> 3567
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3567
gcacagagug caucauccac ua                                                22


<210> 3568
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3568
ugaugauaca gguggaggua g                                                 21


<210> 3569
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3569
cuaccuccac cuguaucauc a                                                 21


<210> 3570
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3570
cuacuucuac cuguguuauc au                                                22


<210> 3571
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3571
augauaacac agguagaagu ag                                                22


<210> 3572
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3572
ugcgacauug gaaguaguau ca                                                22


<210> 3573
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3573
ugauacuacu uccaaugucg ca                                                22


<210> 3574
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3574
uuagaccuag uacacguccu u                                                 21


<210> 3575
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3575
aaggacgugu acuaggucua a                                                 21


<210> 3576
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3576
uuuccuaccc uaccugaaga cu                                                22


<210> 3577
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3577
agucuucagg uaggguagga aa                                                22


<210> 3578
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3578
aucuguaaga gaaaguaaau ga                                                22


<210> 3579
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3579
ucauuuacuu ucucuuacag au                                                22


<210> 3580
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3580
cccggacagg cguucgugcg acgu                                              24


<210> 3581
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3581
acgucgcacg aacgccuguc cggg                                              24


<210> 3582
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3582
accuggaccc agcguagaca aag                                               23


<210> 3583
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3583
cuuugucuac gcugggucca ggu                                               23


<210> 3584
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3584
accaagucug cgucauccuc uc                                                22


<210> 3585
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3585
gagaggauga cgcagacuug gu                                                22


<210> 3586
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3586
aguggaugau ggagacucgg uac                                               23


<210> 3587
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3587
guaccgaguc uccaucaucc acu                                               23


<210> 3588
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3588
guuccacacu gacacugcag aagu                                              24


<210> 3589
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3589
acuucugcag ugucagugug gaac                                              24


<210> 3590
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3590
ccugcugguc aggaguggau acug                                              24


<210> 3591
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3591
caguauccac uccugaccag cagg                                              24


<210> 3592
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3592
gagggucuug ggagggaugu gac                                               23


<210> 3593
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3593
gucacauccc ucccaagacc cuc                                               23


<210> 3594
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3594
auauacaggg ggagacucuu au                                                22


<210> 3595
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3595
auaagagucu cccccuguau au                                                22


<210> 3596
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3596
auauacaggg ggagacucuc au                                                22


<210> 3597
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3597
augagagucu cccccuguau au                                                22


<210> 3598
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3598
agaggauacc cuuuguaugu u                                                 21


<210> 3599
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3599
aacauacaaa ggguauccuc u                                                 21


<210> 3600
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3600
ucuacaaagg aaagcgcuuu cu                                                22


<210> 3601
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3601
agaaagcgcu uuccuuugua ga                                                22


<210> 3602
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3602
ucaaaacuga ggggcauuuu cu                                                22


<210> 3603
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3603
agaaaaugcc ccucaguuuu ga                                                22


<210> 3604
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3604
uucuccaaaa gaaagcacuu ucug                                              24


<210> 3605
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3605
cagaaagugc uuucuuuugg agaa                                              24


<210> 3606
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3606
uucucgagga aagaagcacu uuc                                               23


<210> 3607
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3607
gaaagugcuu cuuuccucga gaa                                               23


<210> 3608
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3608
ccucuagaug gaagcacugu cu                                                22


<210> 3609
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3609
agacagugcu uccaucuaga gg                                                22


<210> 3610
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3610
aucgugcauc ccuuuagagu gu                                                22


<210> 3611
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3611
acacucuaaa gggaugcacg au                                                22


<210> 3612
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3612
aucgugcauc ccuuuagagu gu                                                22


<210> 3613
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3613
acacucuaaa gggaugcacg au                                                22


<210> 3614
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3614
aucgugcauc cuuuuagagu gu                                                22


<210> 3615
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3615
acacucuaaa aggaugcacg au                                                22


<210> 3616
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3616
caaagcgcuc cccuuuagag gu                                                22


<210> 3617
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3617
accucuaaag gggagcgcuu ug                                                22


<210> 3618
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3618
caaagcgcuu cucuuuagag ugu                                               23


<210> 3619
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3619
acacucuaaa gagaagcgcu uug                                               23


<210> 3620
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3620
ucucuggagg gaagcacuuu cug                                               23


<210> 3621
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3621
cagaaagugc uucccuccag aga                                               23


<210> 3622
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3622
gaaagcgcuu cucuuuagag g                                                 21


<210> 3623
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3623
ccucuaaaga gaagcgcuuu c                                                 21


<210> 3624
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3624
cucuagaggg aagcacuuuc uc                                                22


<210> 3625
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3625
gagaaagugc uucccucuag ag                                                22


<210> 3626
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3626
aaagugcauc cuuuuagagu gu                                                22


<210> 3627
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3627
acacucuaaa aggaugcacu uu                                                22


<210> 3628
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3628
cucuagaggg aagcgcuuuc ug                                                22


<210> 3629
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3629
cagaaagcgc uucccucuag ag                                                22


<210> 3630
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3630
caaagugccu cccuuuagag ug                                                22


<210> 3631
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3631
cacucuaaag ggaggcacuu ug                                                22


<210> 3632
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3632
aagugccucc uuuuagagug uu                                                22


<210> 3633
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3633
aacacucuaa aaggaggcac uu                                                22


<210> 3634
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3634
uucuccaaaa gggagcacuu uc                                                22


<210> 3635
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3635
gaaagugcuc ccuuuuggag aa                                                22


<210> 3636
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3636
aaagugcuuc ccuuuggacu gu                                                22


<210> 3637
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3637
acaguccaaa gggaagcacu uu                                                22


<210> 3638
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3638
cuccagaggg aaguacuuuc u                                                 21


<210> 3639
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3639
agaaaguacu ucccucugga g                                                 21


<210> 3640
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3640
acaaagugcu ucccuuuaga gu                                                22


<210> 3641
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3641
acucuaaagg gaagcacuuu gu                                                22


<210> 3642
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3642
cuacaaaggg aagcacuuuc uc                                                22


<210> 3643
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3643
gagaaagugc uucccuuugu ag                                                22


<210> 3644
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3644
gaaggcgcuu cccuuuagag cg                                                22


<210> 3645
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3645
cgcucuaaag ggaagcgccu uc                                                22


<210> 3646
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3646
cuccagaggg augcacuuuc u                                                 21


<210> 3647
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3647
agaaagugca ucccucugga g                                                 21


<210> 3648
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3648
cucuagaggg aagcacuuuc ug                                                22


<210> 3649
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3649
cagaaagugc uucccucuag ag                                                22


<210> 3650
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3650
gaaagugcuu ccuuuuagag gc                                                22


<210> 3651
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3651
gccucuaaaa ggaagcacuu uc                                                22


<210> 3652
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3652
cucuugaggg aagcacuuuc ugu                                               23


<210> 3653
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3653
acagaaagug cuucccucaa gag                                               23


<210> 3654
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3654
acuggacuua gggucagaag gc                                                22


<210> 3655
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3655
gccuucugac ccuaagucca gu                                                22


<210> 3656
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3656
aaacaaacau ggugcacuuc uu                                                22


<210> 3657
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3657
aagaagugca ccauguuugu uu                                                22


<210> 3658
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3658
gaaguugccc auguuauuuu cg                                                22


<210> 3659
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3659
cgaaaauaac augggcaacu uc                                                22


<210> 3660
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3660
aaucauucac ggacaacacu u                                                 21


<210> 3661
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3661
aaguguuguc cgugaaugau u                                                 21


<210> 3662
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3662
gaaguuguuc gugguggauu cg                                                22


<210> 3663
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3663
cgaauccacc acgaacaacu uc                                                22


<210> 3664
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3664
ccuccguguu accuguccuc uag                                               23


<210> 3665
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3665
cuagaggaca gguaacacgg agg                                               23


<210> 3666
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3666
ugaggaugga uagcaaggaa gcc                                               23


<210> 3667
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3667
ggcuuccuug cuauccaucc uca                                               23


<210> 3668
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3668
uucagauccc agcggugccu cu                                                22


<210> 3669
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3669
agaggcaccg cugggaucug aa                                                22


<210> 3670
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3670
guccuaggag gcuccucug                                                    19


<210> 3671
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3671
cagaggagcc uccuaggac                                                    19


<210> 3672
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3672
caauucucaa aggagccucc c                                                 21


<210> 3673
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3673
gggaggcucc uuugagaauu g                                                 21


<210> 3674
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3674
guuggggugc aggggucugc u                                                 21


<210> 3675
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3675
agcagacccc ugcaccccaa c                                                 21


<210> 3676
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3676
uuuccggcuc gcgugggugu gu                                                22


<210> 3677
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3677
acacacccac gcgagccgga aa                                                22


<210> 3678
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3678
ugagugugug ugugugagug ugu                                               23


<210> 3679
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3679
acacacucac acacacacac uca                                               23


<210> 3680
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3680
agugggaggc cagggcacgg ca                                                22


<210> 3681
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3681
ugccgugccc uggccuccca cu                                                22


<210> 3682
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3682
ugagcccugu ccucccgcag                                                   20


<210> 3683
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3683
cugcgggagg acagggcuca                                                   20


<210> 3684
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3684
aagugccgcc aucuuuugag ugu                                               23


<210> 3685
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3685
acacucaaaa gauggcggca cuu                                               23


<210> 3686
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3686
acucaaacug ugggggcacu                                                   20


<210> 3687
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3687
agugccccca caguuugagu                                                   20


<210> 3688
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3688
aagugccccc acaguuugag ugc                                               23


<210> 3689
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3689
gcacucaaac ugugggggca cuu                                               23


<210> 3690
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3690
acucaaaaga uggcggcacu uu                                                22


<210> 3691
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3691
aaagugccgc caucuuuuga gu                                                22


<210> 3692
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3692
aaaccugugu uguucaagag uc                                                22


<210> 3693
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3693
gacucuugaa caacacaggu uu                                                22


<210> 3694
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3694
acaguagagg gaggaaucgc ag                                                22


<210> 3695
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3695
cugcgauucc ucccucuacu gu                                                22


<210> 3696
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3696
gugaaauguu uaggaccacu ag                                                22


<210> 3697
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3697
cuaguggucc uaaacauuuc ac                                                22


<210> 3698
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3698
uugaacuguu aagaaccacu gga                                               23


<210> 3699
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3699
uccagugguu cuuaacaguu caa                                               23


<210> 3700
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3700
uagugguccu aaacauuuca ca                                                22


<210> 3701
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3701
ugugaaaugu uuaggaccac ua                                                22


<210> 3702
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3702
ugcaggacca agaugagccc u                                                 21


<210> 3703
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3703
agggcucauc uugguccugc a                                                 21


<210> 3704
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3704
cucccacaug caggguuugc a                                                 21


<210> 3705
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3705
ugcaaacccu gcauguggga g                                                 21


<210> 3706
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3706
caucccuugc augguggagg g                                                 21


<210> 3707
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3707
cccuccacca ugcaagggau g                                                 21


<210> 3708
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3708
aaaaugaaau gagcccagcc ca                                                22


<210> 3709
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3709
ugggcugggc ucauuucauu uu                                                22


<210> 3710
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3710
agccgcgggg aucgccgagg g                                                 21


<210> 3711
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3711
cccucggcga uccccgcggc u                                                 21


<210> 3712
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3712
agggaccuga gugucuaag                                                    19


<210> 3713
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3713
cuuagacacu caggucccu                                                    19


<210> 3714
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3714
aggugugucu guagagucc                                                    19


<210> 3715
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3715
ggacucuaca gacacaccu                                                    19


<210> 3716
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3716
cauagcccgg ucgcugguac auga                                              24


<210> 3717
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3717
ucauguacca gcgaccgggc uaug                                              24


<210> 3718
<211> 18
<212> RNA
<213> Homo sapiens

<400> 3718
cggcuggagg ugugagga                                                     18


<210> 3719
<211> 18
<212> RNA
<213> Homo sapiens

<400> 3719
uccucacacc uccagccg                                                     18


<210> 3720
<211> 18
<212> RNA
<213> Homo sapiens

<400> 3720
cuaagaaguu gacugaag                                                     18


<210> 3721
<211> 18
<212> RNA
<213> Homo sapiens

<400> 3721
cuucagucaa cuucuuag                                                     18


<210> 3722
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3722
gacuggacaa gcugaggaa                                                    19


<210> 3723
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3723
uuccucagcu uguccaguc                                                    19


<210> 3724
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3724
gcuugucgcu gcgguguugc u                                                 21


<210> 3725
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3725
agcaacaccg cagcgacaag c                                                 21


<210> 3726
<211> 17
<212> RNA
<213> Homo sapiens

<400> 3726
ggcgggugcg ggggugg                                                      17


<210> 3727
<211> 17
<212> RNA
<213> Homo sapiens

<400> 3727
ccacccccgc acccgcc                                                      17


<210> 3728
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3728
ugugucccau uauuggugau u                                                 21


<210> 3729
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3729
aaucaccaau aaugggacac a                                                 21


<210> 3730
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3730
uuuaagaaaa caccauggag au                                                22


<210> 3731
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3731
aucuccaugg uguuuucuua aa                                                22


<210> 3732
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3732
gcuauuucac gacaccaggg uu                                                22


<210> 3733
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3733
aacccuggug ucgugaaaua gc                                                22


<210> 3734
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3734
agcugguguu gugaaucagg ccg                                               23


<210> 3735
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3735
cggccugauu cacaacacca gcu                                               23


<210> 3736
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3736
aauaauacau gguugaucuu u                                                 21


<210> 3737
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3737
aaagaucaac cauguauuau u                                                 21


<210> 3738
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3738
agaucgaccg uguuauauuc gc                                                22


<210> 3739
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3739
gcgaauauaa cacggucgau cu                                                22


<210> 3740
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3740
aaucaugugc agugccaaua ug                                                22


<210> 3741
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3741
cauauuggca cugcacauga uu                                                22


<210> 3742
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3742
uuuggcacua gcacauuuuu gcu                                               23


<210> 3743
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3743
agcaaaaaug ugcuagugcc aaa                                               23


<210> 3744
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3744
uccuguacug agcugccccg ag                                                22


<210> 3745
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3745
cucggggcag cucaguacag ga                                                22


<210> 3746
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3746
gcuacuucac aacaccaggg cc                                                22


<210> 3747
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3747
ggcccuggug uugugaagua gc                                                22


<210> 3748
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3748
caucaucguc ucaaaugagu cu                                                22


<210> 3749
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3749
agacucauuu gagacgauga ug                                                22


<210> 3750
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3750
acuccauuug uuuugaugau gga                                               23


<210> 3751
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3751
uccaucauca aaacaaaugg agu                                               23


<210> 3752
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3752
cuccuacaua uuagcauuaa ca                                                22


<210> 3753
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3753
uguuaaugcu aauauguagg ag                                                22


<210> 3754
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3754
uuaaugcuaa ucgugauagg ggu                                               23


<210> 3755
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3755
accccuauca cgauuagcau uaa                                               23


<210> 3756
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3756
agaucagaag gugauugugg cu                                                22


<210> 3757
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3757
agccacaauc accuucugau cu                                                22


<210> 3758
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3758
uacugcagac guggcaauca ug                                                22


<210> 3759
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3759
caugauugcc acgucugcag ua                                                22


<210> 3760
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3760
guuagggcca acaucucuug g                                                 21


<210> 3761
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3761
ccaagagaug uuggcccuaa c                                                 21


<210> 3762
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3762
aacauagagg aaauuccacg u                                                 21


<210> 3763
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3763
acguggaauu uccucuaugu u                                                 21


<210> 3764
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3764
gguggauauu ccuucuaugu u                                                 21


<210> 3765
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3765
aacauagaag gaauauccac c                                                 21


<210> 3766
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3766
ucauagcccu guacaaugcu gcu                                               23


<210> 3767
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3767
agcagcauug uacagggcua uga                                               23


<210> 3768
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3768
uaacacuguc ugguaaagau gg                                                22


<210> 3769
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3769
ccaucuuuac cagacagugu ua                                                22


<210> 3770
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3770
caucuuccag uacaguguug ga                                                22


<210> 3771
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3771
uccaacacug uacuggaaga ug                                                22


<210> 3772
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3772
aacuggccua caaaguccca gu                                                22


<210> 3773
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3773
acugggacuu uguaggccag uu                                                22


<210> 3774
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3774
ugggucuuug cgggcgagau ga                                                22


<210> 3775
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3775
ucaucucgcc cgcaaagacc ca                                                22


<210> 3776
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3776
augaccuaug aauugacaga c                                                 21


<210> 3777
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3777
gucugucaau ucauagguca u                                                 21


<210> 3778
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3778
aagcugccag uugaagaacu gu                                                22


<210> 3779
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3779
acaguucuuc aacuggcagc uu                                                22


<210> 3780
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3780
aguucuucag uggcaagcuu ua                                                22


<210> 3781
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3781
uaaagcuugc cacugaagaa cu                                                22


<210> 3782
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3782
acagauucga uucuagggga au                                                22


<210> 3783
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3783
auuccccuag aaucgaaucu gu                                                22


<210> 3784
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3784
uacccuguag aaccgaauuu gug                                               23


<210> 3785
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3785
cacaaauucg guucuacagg gua                                               23


<210> 3786
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3786
uagcagcacg uaaauauugg cg                                                22


<210> 3787
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3787
cgccaauauu uacgugcugc ua                                                22


<210> 3788
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3788
ugagaugaag cacuguagcu c                                                 21


<210> 3789
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3789
gagcuacagu gcuucaucuc a                                                 21


<210> 3790
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3790
ggugcagugc ugcaucucug gu                                                22


<210> 3791
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3791
accagagaug cagcacugca cc                                                22


<210> 3792
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3792
uugcucacug uucuucccua g                                                 21


<210> 3793
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3793
cuagggaaga acagugagca a                                                 21


<210> 3794
<211> 18
<212> RNA
<213> Homo sapiens

<400> 3794
cagggucagc ugagcaug                                                     18


<210> 3795
<211> 18
<212> RNA
<213> Homo sapiens

<400> 3795
caugcucagc ugacccug                                                     18


<210> 3796
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3796
aagcauucuu ucauugguug g                                                 21


<210> 3797
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3797
ccaaccaaug aaagaaugcu u                                                 21


<210> 3798
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3798
ccgucgccgc cacccgagcc g                                                 21


<210> 3799
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3799
cggcucgggu ggcggcgacg g                                                 21


<210> 3800
<211> 27
<212> RNA
<213> Homo sapiens

<400> 3800
cacuguaggu gauggugaga gugggca                                           27


<210> 3801
<211> 27
<212> RNA
<213> Homo sapiens

<400> 3801
ugcccacucu caccaucacc uacagug                                           27


<210> 3802
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3802
gggaugguag accggugacg ugc                                               23


<210> 3803
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3803
gcacgucacc ggucuaccau ccc                                               23


<210> 3804
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3804
uaggacacau ggucuacuuc u                                                 21


<210> 3805
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3805
agaaguagac cauguguccu a                                                 21


<210> 3806
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3806
cuccugagcc auucugagcc uc                                                22


<210> 3807
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3807
gaggcucaga auggcucagg ag                                                22


<210> 3808
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3808
gugccagcug caguggggga g                                                 21


<210> 3809
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3809
cucccccacu gcagcuggca c                                                 21


<210> 3810
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3810
cccggagcca ggaugcagcu c                                                 21


<210> 3811
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3811
gagcugcauc cuggcuccgg g                                                 21


<210> 3812
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3812
ucguggccug gucuccauua u                                                 21


<210> 3813
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3813
auaauggaga ccaggccacg a                                                 21


<210> 3814
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3814
ucugcagggu uugcuuugag                                                   20


<210> 3815
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3815
cucaaagcaa acccugcaga                                                   20


<210> 3816
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3816
uguucaugua gauguuuaag c                                                 21


<210> 3817
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3817
gcuuaaacau cuacaugaac a                                                 21


<210> 3818
<211> 18
<212> RNA
<213> Homo sapiens

<400> 3818
ucagcuggcc cucauuuc                                                     18


<210> 3819
<211> 18
<212> RNA
<213> Homo sapiens

<400> 3819
gaaaugaggg ccagcuga                                                     18


<210> 3820
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3820
uggcagggag gcugggaggg g                                                 21


<210> 3821
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3821
ccccucccag ccucccugcc a                                                 21


<210> 3822
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3822
ucacuguuca gacaggcgga                                                   20


<210> 3823
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3823
uccgccuguc ugaacaguga                                                   20


<210> 3824
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3824
ccccaccucc ucucuccuca g                                                 21


<210> 3825
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3825
cugaggagag aggagguggg g                                                 21


<210> 3826
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3826
gugaggacuc gggaggugg                                                    19


<210> 3827
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3827
ccaccucccg aguccucac                                                    19


<210> 3828
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3828
ugagccccug ugccgccccc ag                                                22


<210> 3829
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3829
cugggggcgg cacaggggcu ca                                                22


<210> 3830
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3830
guggguacgg cccagugggg gg                                                22


<210> 3831
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3831
ccccccacug ggccguaccc ac                                                22


<210> 3832
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3832
ucaccagccc uguguucccu ag                                                22


<210> 3833
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3833
cuagggaaca cagggcuggu ga                                                22


<210> 3834
<211> 26
<212> RNA
<213> Homo sapiens

<400> 3834
gugagggcau gcaggccugg augggg                                            26


<210> 3835
<211> 26
<212> RNA
<213> Homo sapiens

<400> 3835
ccccauccag gccugcaugc ccucac                                            26


<210> 3836
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3836
cucucaccac ugcccuccca cag                                               23


<210> 3837
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3837
cugugggagg gcagugguga gag                                               23


<210> 3838
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3838
guggguaggg uuugggggag agcg                                              24


<210> 3839
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3839
cgcucucccc caaacccuac ccac                                              24


<210> 3840
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3840
gugucugggc ggacagcugc                                                   20


<210> 3841
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3841
gcagcugucc gcccagacac                                                   20


<210> 3842
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3842
cuuccucguc ugucugcccc                                                   20


<210> 3843
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3843
ggggcagaca gacgaggaag                                                   20


<210> 3844
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3844
gugaguggga gccccagugu gug                                               23


<210> 3845
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3845
cacacacugg ggcucccacu cac                                               23


<210> 3846
<211> 27
<212> RNA
<213> Homo sapiens

<400> 3846
accuucuugu auaagcacug ugcuaaa                                           27


<210> 3847
<211> 27
<212> RNA
<213> Homo sapiens

<400> 3847
uuuagcacag ugcuuauaca agaaggu                                           27


<210> 3848
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3848
ggcgacaaaa cgagacccug uc                                                22


<210> 3849
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3849
gacagggucu cguuuugucg cc                                                22


<210> 3850
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3850
uugcuugaac ccaggaagug ga                                                22


<210> 3851
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3851
uccacuuccu ggguucaagc aa                                                22


<210> 3852
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3852
ggagauggag guugcagug                                                    19


<210> 3853
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3853
cacugcaacc uccaucucc                                                    19


<210> 3854
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3854
accacugcac uccagccuga g                                                 21


<210> 3855
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3855
cucaggcugg agugcagugg u                                                 21


<210> 3856
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3856
ggugguugag gcugcaguaa gu                                                22


<210> 3857
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3857
acuuacugca gccucaacca cc                                                22


<210> 3858
<211> 17
<212> RNA
<213> Homo sapiens

<400> 3858
ucgccuccuc cucuccc                                                      17


<210> 3859
<211> 17
<212> RNA
<213> Homo sapiens

<400> 3859
gggagaggag gaggcga                                                      17


<210> 3860
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3860
ucuauacaga cccuggcuuu uc                                                22


<210> 3861
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3861
gaaaagccag ggucuguaua ga                                                22


<210> 3862
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3862
ucugggcaac aaagugagac cu                                                22


<210> 3863
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3863
aggucucacu uuguugccca ga                                                22


<210> 3864
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3864
gaucucacuu uguugcccag g                                                 21


<210> 3865
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3865
ccugggcaac aaagugagau c                                                 21


<210> 3866
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3866
ucgcgccccg gcucccguuc                                                   20


<210> 3867
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3867
gaacgggagc cggggcgcga                                                   20


<210> 3868
<211> 25
<212> RNA
<213> Homo sapiens

<400> 3868
ugggaacggg uuccggcaga cgcug                                             25


<210> 3869
<211> 25
<212> RNA
<213> Homo sapiens

<400> 3869
cagcgucugc cggaacccgu uccca                                             25


<210> 3870
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3870
uuaggccgca gaucugggug a                                                 21


<210> 3871
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3871
ucacccagau cugcggccua a                                                 21


<210> 3872
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3872
aauaggccac ggaucugggc aa                                                22


<210> 3873
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3873
uugcccagau ccguggccua uu                                                22


<210> 3874
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3874
cacccagauc ugcggccuaa u                                                 21


<210> 3875
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3875
auuaggccgc agaucugggu g                                                 21


<210> 3876
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3876
uuagggcccu ggcuccaucu cc                                                22


<210> 3877
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3877
ggagauggag ccagggcccu aa                                                22


<210> 3878
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3878
uucauucggc uguccagaug ua                                                22


<210> 3879
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3879
uacaucugga cagccgaaug aa                                                22


<210> 3880
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3880
uugcagcugc cugggaguga cuuc                                              24


<210> 3881
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3881
gaagucacuc ccaggcagcu gcaa                                              24


<210> 3882
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3882
uugggacaua cuuaugcuaa a                                                 21


<210> 3883
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3883
uuuagcauaa guauguccca a                                                 21


<210> 3884
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3884
ucucacugua gccucgaacc cc                                                22


<210> 3885
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3885
gggguucgag gcuacaguga ga                                                22


<210> 3886
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3886
uuugaggcua cagugagaug ug                                                22


<210> 3887
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3887
cacaucucac uguagccuca aa                                                22


<210> 3888
<211> 18
<212> RNA
<213> Homo sapiens

<400> 3888
cagggaggug aaugugau                                                     18


<210> 3889
<211> 18
<212> RNA
<213> Homo sapiens

<400> 3889
aucacauuca ccucccug                                                     18


<210> 3890
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3890
gaugaugcug cugaugcug                                                    19


<210> 3891
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3891
cagcaucagc agcaucauc                                                    19


<210> 3892
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3892
ccagacagaa uucuaugcac uuuc                                              24


<210> 3893
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3893
gaaagugcau agaauucugu cugg                                              24


<210> 3894
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3894
cuccuggggc ccgcacucuc gc                                                22


<210> 3895
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3895
gcgagagugc gggccccagg ag                                                22


<210> 3896
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3896
cuccguuugc cuguuucgcu g                                                 21


<210> 3897
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3897
cagcgaaaca ggcaaacgga g                                                 21


<210> 3898
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3898
cucggcgcgg ggcgcgggcu cc                                                22


<210> 3899
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3899
ggagcccgcg ccccgcgccg ag                                                22


<210> 3900
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3900
gcccuccgcc cgugcacccc g                                                 21


<210> 3901
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3901
cggggugcac gggcggaggg c                                                 21


<210> 3902
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3902
gcccgcgugu ggagccaggu gu                                                22


<210> 3903
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3903
acaccuggcu ccacacgcgg gc                                                22


<210> 3904
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3904
aaaaccgucu aguuacaguu gu                                                22


<210> 3905
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3905
acaacuguaa cuagacgguu uu                                                22


<210> 3906
<211> 18
<212> RNA
<213> Homo sapiens

<400> 3906
uccagugccc uccucucc                                                     18


<210> 3907
<211> 18
<212> RNA
<213> Homo sapiens

<400> 3907
ggagaggagg gcacugga                                                     18


<210> 3908
<211> 18
<212> RNA
<213> Homo sapiens

<400> 3908
ugaggcagua gauugaau                                                     18


<210> 3909
<211> 18
<212> RNA
<213> Homo sapiens

<400> 3909
auucaaucua cugccuca                                                     18


<210> 3910
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3910
aggggcuggc uuuccucugg uc                                                22


<210> 3911
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3911
gaccagagga aagccagccc cu                                                22


<210> 3912
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3912
uggagagaaa ggcaguuccu ga                                                22


<210> 3913
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3913
ucaggaacug ccuuucucuc ca                                                22


<210> 3914
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3914
ucgugucuug uguugcagcc gg                                                22


<210> 3915
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3915
ccggcugcaa cacaagacac ga                                                22


<210> 3916
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3916
ggcuacaaca caggacccgg gc                                                22


<210> 3917
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3917
gcccgggucc uguguuguag cc                                                22


<210> 3918
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3918
cggcggggac ggcgauuggu c                                                 21


<210> 3919
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3919
gaccaaucgc cguccccgcc g                                                 21


<210> 3920
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3920
cgcaggggcc gggugcucac cg                                                22


<210> 3921
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3921
cggugagcac ccggccccug cg                                                22


<210> 3922
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3922
ugagugccgg ugccugcccu g                                                 21


<210> 3923
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3923
cagggcaggc accggcacuc a                                                 21


<210> 3924
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3924
gcugcgcuug gauuucgucc cc                                                22


<210> 3925
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3925
ggggacgaaa uccaagcgca gc                                                22


<210> 3926
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3926
caacggaauc ccaaaagcag cug                                               23


<210> 3927
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3927
cagcugcuuu ugggauuccg uug                                               23


<210> 3928
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3928
ucaggccagg cacaguggcu ca                                                22


<210> 3929
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3929
ugagccacug ugccuggccu ga                                                22


<210> 3930
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3930
accgugcaaa gguagcaua                                                    19


<210> 3931
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3931
uaugcuaccu uugcacggu                                                    19


<210> 3932
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3932
ccuccugccc uccuugcugu                                                   20


<210> 3933
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3933
acagcaagga gggcaggagg                                                   20


<210> 3934
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3934
uguuuugaua acaguaaugu                                                   20


<210> 3935
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3935
acauuacugu uaucaaaaca                                                   20


<210> 3936
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3936
guguuaauua aaccucuauu uac                                               23


<210> 3937
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3937
guaaauagag guuuaauuaa cac                                               23


<210> 3938
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3938
cuguaauaua aauuuaauuu auu                                               23


<210> 3939
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3939
aauaaauuaa auuuauauua cag                                               23


<210> 3940
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3940
uuggggaaac ggccgcugag ug                                                22


<210> 3941
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3941
cacucagcgg ccguuucccc aa                                                22


<210> 3942
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3942
ccucccaugc caagaacucc c                                                 21


<210> 3943
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3943
gggaguucuu ggcaugggag g                                                 21


<210> 3944
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3944
gguucuuagc auaggagguc u                                                 21


<210> 3945
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3945
agaccuccua ugcuaagaac c                                                 21


<210> 3946
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3946
uguucucuuu gccaaggaca g                                                 21


<210> 3947
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3947
cuguccuugg caaagagaac a                                                 21


<210> 3948
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3948
aaaucucugc aggcaaaugu ga                                                22


<210> 3949
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3949
ucacauuugc cugcagagau uu                                                22


<210> 3950
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3950
caugguucug ucaagcaccg cg                                                22


<210> 3951
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3951
cgcggugcuu gacagaacca ug                                                22


<210> 3952
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3952
uugugcuuga ucuaaccaug u                                                 21


<210> 3953
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3953
acaugguuag aucaagcaca a                                                 21


<210> 3954
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3954
ucugcaagug ucagaggcga gg                                                22


<210> 3955
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3955
ccucgccucu gacacuugca ga                                                22


<210> 3956
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3956
gagagcagug uguguugccu gg                                                22


<210> 3957
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3957
ccaggcaaca cacacugcuc uc                                                22


<210> 3958
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3958
aucacauugc cagugauuac cc                                                22


<210> 3959
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3959
ggguaaucac uggcaaugug au                                                22


<210> 3960
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3960
agcagaggca gagaggcuca gg                                                22


<210> 3961
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3961
ccugagccuc ucugccucug cu                                                22


<210> 3962
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3962
ugaggcucug uuagccuugg cuc                                               23


<210> 3963
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3963
gagccaaggc uaacagagcc uca                                               23


<210> 3964
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3964
uaucauggag uugguaaagc ac                                                22


<210> 3965
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3965
gugcuuuacc aacuccauga ua                                                22


<210> 3966
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3966
guuuuaccac cuccaggaga cu                                                22


<210> 3967
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3967
agucuccugg aggugguaaa ac                                                22


<210> 3968
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3968
cgccucuuca gcgcugucuu cc                                                22


<210> 3969
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3969
ggaagacagc gcugaagagg cg                                                22


<210> 3970
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3970
caggcaguga cuguucagac guc                                               23


<210> 3971
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3971
gacgucugaa cagucacugc cug                                               23


<210> 3972
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3972
agaauugcgu uuggacaauc agu                                               23


<210> 3973
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3973
acugauuguc caaacgcaau ucu                                               23


<210> 3974
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3974
agauguccag ccacaauucu cg                                                22


<210> 3975
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3975
cgagaauugu ggcuggacau cu                                                22


<210> 3976
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3976
agcagaagca gggagguucu ccca                                              24


<210> 3977
<211> 24
<212> RNA
<213> Homo sapiens

<400> 3977
ugggagaacc ucccugcuuc ugcu                                              24


<210> 3978
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3978
uaugugggau gguaaaccgc uu                                                22


<210> 3979
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3979
aagcgguuua ccaucccaca ua                                                22


<210> 3980
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3980
ugguuuaccg ucccacauac au                                                22


<210> 3981
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3981
auguaugugg gacgguaaac ca                                                22


<210> 3982
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3982
cagugcaaug auauugucaa agc                                               23


<210> 3983
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3983
gcuuugacaa uaucauugca cug                                               23


<210> 3984
<211> 17
<212> RNA
<213> Homo sapiens

<400> 3984
uaauugcuuc cauguuu                                                      17


<210> 3985
<211> 17
<212> RNA
<213> Homo sapiens

<400> 3985
aaacauggaa gcaauua                                                      17


<210> 3986
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3986
uugccacacu gcaacaccuu aca                                               23


<210> 3987
<211> 23
<212> RNA
<213> Homo sapiens

<400> 3987
uguaaggugu ugcagugugg caa                                               23


<210> 3988
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3988
ucuggcuguu guggugugca a                                                 21


<210> 3989
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3989
uugcacacca caacagccag a                                                 21


<210> 3990
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3990
gauaucagcu caguaggcac cg                                                22


<210> 3991
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3991
cggugccuac ugagcugaua uc                                                22


<210> 3992
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3992
guuccugcug aacugagcca g                                                 21


<210> 3993
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3993
cuggcucagu ucagcaggaa c                                                 21


<210> 3994
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3994
auauggguuu acuaguuggu                                                   20


<210> 3995
<211> 20
<212> RNA
<213> Homo sapiens

<400> 3995
accaacuagu aaacccauau                                                   20


<210> 3996
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3996
ugcuaugcca acauauugcc au                                                22


<210> 3997
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3997
auggcaauau guuggcauag ca                                                22


<210> 3998
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3998
aggcaagaug cuggcauagc u                                                 21


<210> 3999
<211> 21
<212> RNA
<213> Homo sapiens

<400> 3999
agcuaugcca gcaucuugcc u                                                 21


<210> 4000
<211> 18
<212> RNA
<213> Homo sapiens

<400> 4000
cggggcggca ggggccuc                                                     18


<210> 4001
<211> 18
<212> RNA
<213> Homo sapiens

<400> 4001
gaggccccug ccgccccg                                                     18


<210> 4002
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4002
aaaagcuggg uugagagga                                                    19


<210> 4003
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4003
uccucucaac ccagcuuuu                                                    19


<210> 4004
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4004
cccaauacac ggucgaccuc uu                                                22


<210> 4005
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4005
aagaggucga ccguguauug gg                                                22


<210> 4006
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4006
agguuguccg uggugaguuc gca                                               23


<210> 4007
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4007
ugcgaacuca ccacggacaa ccu                                               23


<210> 4008
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4008
gcaaagcaca cggccugcag aga                                               23


<210> 4009
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4009
ucucugcagg ccgugugcuu ugc                                               23


<210> 4010
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4010
ucucugggcc ugugucuuag gc                                                22


<210> 4011
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4011
gccuaagaca caggcccaga ga                                                22


<210> 4012
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4012
gccccugggc cuauccuaga a                                                 21


<210> 4013
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4013
uucuaggaua ggcccagggg c                                                 21


<210> 4014
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4014
uccgucucag uuacuuuaua gc                                                22


<210> 4015
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4015
gcuauaaagu aacugagacg ga                                                22


<210> 4016
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4016
aacacaccua uucaaggauu ca                                                22


<210> 4017
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4017
ugaauccuug aauaggugug uu                                                22


<210> 4018
<211> 24
<212> RNA
<213> Homo sapiens

<400> 4018
aauccuugga accuaggugu gagu                                              24


<210> 4019
<211> 24
<212> RNA
<213> Homo sapiens

<400> 4019
acucacaccu agguuccaag gauu                                              24


<210> 4020
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4020
uaaugccccu aaaaauccuu au                                                22


<210> 4021
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4021
auaaggauuu uuaggggcau ua                                                22


<210> 4022
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4022
agggacuuuu gggggcagau gug                                               23


<210> 4023
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4023
cacaucugcc cccaaaaguc ccu                                               23


<210> 4024
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4024
uaaugccccu aaaaauccuu au                                                22


<210> 4025
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4025
auaaggauuu uuaggggcau ua                                                22


<210> 4026
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4026
agggacuuuc aggggcagcu gu                                                22


<210> 4027
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4027
acagcugccc cugaaagucc cu                                                22


<210> 4028
<211> 24
<212> RNA
<213> Homo sapiens

<400> 4028
gaaaaugaug aguagugacu gaug                                              24


<210> 4029
<211> 24
<212> RNA
<213> Homo sapiens

<400> 4029
caucagucac uacucaucau uuuc                                              24


<210> 4030
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4030
ugagcaccac acaggccggg cgc                                               23


<210> 4031
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4031
gcgcccggcc uguguggugc uca                                               23


<210> 4032
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4032
gcuggucugc guggugcucg g                                                 21


<210> 4033
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4033
ccgagcacca cgcagaccag c                                                 21


<210> 4034
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4034
gccugcuggg guggaaccug gu                                                22


<210> 4035
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4035
accagguucc accccagcag gc                                                22


<210> 4036
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4036
gaagugcuuc gauuuugggg ugu                                               23


<210> 4037
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4037
acaccccaaa aucgaagcac uuc                                               23


<210> 4038
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4038
acucaaaaug ggggcgcuuu cc                                                22


<210> 4039
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4039
ggaaagcgcc cccauuuuga gu                                                22


<210> 4040
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4040
uauguaacau gguccacuaa cu                                                22


<210> 4041
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4041
aguuagugga ccauguuaca ua                                                22


<210> 4042
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4042
ugguagacua uggaacguag g                                                 21


<210> 4043
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4043
ccuacguucc auagucuacc a                                                 21


<210> 4044
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4044
uguagauacg agcaccagcc ac                                                22


<210> 4045
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4045
guggcuggug cucguaucua ca                                                22


<210> 4046
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4046
acaggcggcu guagcaaugg ggg                                               23


<210> 4047
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4047
cccccauugc uacagccgcc ugu                                               23


<210> 4048
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4048
aauucccuug uagauaaccc gg                                                22


<210> 4049
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4049
ccggguuauc uacaagggaa uu                                                22


<210> 4050
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4050
uacgcgcaga ccacaggaug uc                                                22


<210> 4051
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4051
gacauccugu ggucugcgcg ua                                                22


<210> 4052
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4052
uuacacacaa cugaggauca ua                                                22


<210> 4053
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4053
uaugauccuc aguugugugu aa                                                22


<210> 4054
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4054
uagcccccag gcuucacuug gcg                                               23


<210> 4055
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4055
cgccaaguga agccuggggg cua                                               23


<210> 4056
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4056
agggcauagg agaggguuga uau                                               23


<210> 4057
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4057
auaucaaccc ucuccuaugc ccu                                               23


<210> 4058
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4058
gaauguugcu cggugaaccc cu                                                22


<210> 4059
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4059
agggguucac cgagcaacau uc                                                22


<210> 4060
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4060
agguuacccg agcaacuuug cau                                               23


<210> 4061
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4061
augcaaaguu gcucggguaa ccu                                               23


<210> 4062
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4062
uauguaacac gguccacuaa cc                                                22


<210> 4063
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4063
gguuagugga ccguguuaca ua                                                22


<210> 4064
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4064
uaguagaccg uauagcguac g                                                 21


<210> 4065
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4065
cguacgcuau acggucuacu a                                                 21


<210> 4066
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4066
acuucaccug guccacuagc cgu                                               23


<210> 4067
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4067
acggcuagug gaccagguga agu                                               23


<210> 4068
<211> 18
<212> RNA
<213> Homo sapiens

<400> 4068
guguucucug auggacag                                                     18


<210> 4069
<211> 18
<212> RNA
<213> Homo sapiens

<400> 4069
cuguccauca gagaacac                                                     18


<210> 4070
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4070
caggucgucu ugcagggcuu cu                                                22


<210> 4071
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4071
agaagcccug caagacgacc ug                                                22


<210> 4072
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4072
ugucuugcag gccgucaugc a                                                 21


<210> 4073
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4073
ugcaugacgg ccugcaagac a                                                 21


<210> 4074
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4074
aucaugaugg gcuccucggu gu                                                22


<210> 4075
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4075
acaccgagga gcccaucaug au                                                22


<210> 4076
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4076
uugcuaguug cacuccucuc ugu                                               23


<210> 4077
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4077
acagagagga gugcaacuag caa                                               23


<210> 4078
<211> 25
<212> RNA
<213> Homo sapiens

<400> 4078
uaggcagugu auugcuagcg gcugu                                             25


<210> 4079
<211> 25
<212> RNA
<213> Homo sapiens

<400> 4079
acagccgcua gcaauacacu gccua                                             25


<210> 4080
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4080
auuggggaca uuuugcauuc au                                                22


<210> 4081
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4081
augaaugcaa aaugucccca au                                                22


<210> 4082
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4082
uuuugcgaug uguuccuaau au                                                22


<210> 4083
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4083
auauuaggaa cacaucgcaa aa                                                22


<210> 4084
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4084
uugggaucau uuugcaucca ua                                                22


<210> 4085
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4085
uauggaugca aaaugauccc aa                                                22


<210> 4086
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4086
uuuugcaaua uguuccugaa ua                                                22


<210> 4087
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4087
uauucaggaa cauauugcaa aa                                                22


<210> 4088
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4088
gcaguccaug ggcauauaca c                                                 21


<210> 4089
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4089
guguauaugc ccauggacug c                                                 21


<210> 4090
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4090
uaugugccuu uggacuacau cg                                                22


<210> 4091
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4091
cgauguaguc caaaggcaca ua                                                22


<210> 4092
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4092
auacacauac acgcaacaca cau                                               23


<210> 4093
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4093
auguguguug cguguaugug uau                                               23


<210> 4094
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4094
uugcauguca gauuguaauu ccc                                               23


<210> 4095
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4095
gggaauuaca aucugacaug caa                                               23


<210> 4096
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4096
ucacuccucu ccucccgucu u                                                 21


<210> 4097
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4097
aagacgggag gagaggagug a                                                 21


<210> 4098
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4098
ucaggcucag uccccucccg au                                                22


<210> 4099
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4099
aucgggaggg gacugagccu ga                                                22


<210> 4100
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4100
gucauacacg gcucuccucu cu                                                22


<210> 4101
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4101
agagaggaga gccguguaug ac                                                22


<210> 4102
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4102
agaggcuggc cgugaugaau uc                                                22


<210> 4103
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4103
gaauucauca cggccagccu cu                                                22


<210> 4104
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4104
aaucauacag ggacauccag uu                                                22


<210> 4105
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4105
aacuggaugu cccuguauga uu                                                22


<210> 4106
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4106
aaucguacag ggucauccac uu                                                22


<210> 4107
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4107
aaguggauga cccuguacga uu                                                22


<210> 4108
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4108
uugaaaggcu auuucuuggu c                                                 21


<210> 4109
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4109
gaccaagaaa uagccuuuca a                                                 21


<210> 4110
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4110
cccagauaau ggcacucuca a                                                 21


<210> 4111
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4111
uugagagugc cauuaucugg g                                                 21


<210> 4112
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4112
caaccuggag gacuccaugc ug                                                22


<210> 4113
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4113
cagcauggag uccuccaggu ug                                                22


<210> 4114
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4114
ccauggaucu ccaggugggu                                                   20


<210> 4115
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4115
acccaccugg agauccaugg                                                   20


<210> 4116
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4116
cuuaugcaag auucccuucu ac                                                22


<210> 4117
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4117
guagaaggga aucuugcaua ag                                                22


<210> 4118
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4118
aguggggaac ccuuccauga gg                                                22


<210> 4119
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4119
ccucauggaa ggguucccca cu                                                22


<210> 4120
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4120
aggaccugcg ggacaagauu cuu                                               23


<210> 4121
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4121
aagaaucuug ucccgcaggu ccu                                               23


<210> 4122
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4122
caaaccacac ugugguguua ga                                                22


<210> 4123
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4123
ucuaacacca cagugugguu ug                                                22


<210> 4124
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4124
cagcagcaca cugugguuug u                                                 21


<210> 4125
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4125
acaaaccaca gugugcugcu g                                                 21


<210> 4126
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4126
uuucaagcca gggggcguuu uuc                                               23


<210> 4127
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4127
gaaaaacgcc cccuggcuug aaa                                               23


<210> 4128
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4128
ucacuaccug acaauacagu                                                   20


<210> 4129
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4129
acuguauugu cagguaguga                                                   20


<210> 4130
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4130
ugcuguauug ucagguagug a                                                 21


<210> 4131
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4131
ucacuaccug acaauacagc a                                                 21


<210> 4132
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4132
uucugccucu guccaggucc uu                                                22


<210> 4133
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4133
aaggaccugg acagaggcag aa                                                22


<210> 4134
<211> 24
<212> RNA
<213> Homo sapiens

<400> 4134
agggcuggac ucagcggcgg agcu                                              24


<210> 4135
<211> 24
<212> RNA
<213> Homo sapiens

<400> 4135
agcuccgccg cugaguccag cccu                                              24


<210> 4136
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4136
ugacugccuc acugaccacu u                                                 21


<210> 4137
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4137
aaguggucag ugaggcaguc a                                                 21


<210> 4138
<211> 24
<212> RNA
<213> Homo sapiens

<400> 4138
aauuugguuu cugaggcacu uagu                                              24


<210> 4139
<211> 24
<212> RNA
<213> Homo sapiens

<400> 4139
acuaagugcc ucagaaacca aauu                                              24


<210> 4140
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4140
uacuuuucua gguuguuggg g                                                 21


<210> 4141
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4141
ccccaacaac cuagaaaagu a                                                 21


<210> 4142
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4142
ucacaacaac cuugcagggu aga                                               23


<210> 4143
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4143
ucuacccugc aagguuguug uga                                               23


<210> 4144
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4144
cuuggauuuu ccugggccuc ag                                                22


<210> 4145
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4145
cugaggccca ggaaaaucca ag                                                22


<210> 4146
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4146
ugaggacagg gcaaauucac ga                                                22


<210> 4147
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4147
ucgugaauuu gcccuguccu ca                                                22


<210> 4148
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4148
aucauaugaa ccaaacucua au                                                22


<210> 4149
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4149
auuagaguuu gguucauaug au                                                22


<210> 4150
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4150
uagagucugg cugauauggu uu                                                22


<210> 4151
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4151
aaaccauauc agccagacuc ua                                                22


<210> 4152
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4152
ccugugcucc cagggccucg c                                                 21


<210> 4153
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4153
gcgaggcccu gggagcacag g                                                 21


<210> 4154
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4154
ugaggcccuu ggggcacagu gg                                                22


<210> 4155
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4155
ccacugugcc ccaagggccu ca                                                22


<210> 4156
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4156
uccuaaaucu gaaaguccaa aa                                                22


<210> 4157
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4157
uuuuggacuu ucagauuuag ga                                                22


<210> 4158
<211> 24
<212> RNA
<213> Homo sapiens

<400> 4158
uuggacuuuu ucagauuugg ggau                                              24


<210> 4159
<211> 24
<212> RNA
<213> Homo sapiens

<400> 4159
auccccaaau cugaaaaagu ccaa                                              24


<210> 4160
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4160
augcaccugg gcaaggauuc ug                                                22


<210> 4161
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4161
cagaauccuu gcccaggugc au                                                22


<210> 4162
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4162
uaauccuugc uaccugggug aga                                               23


<210> 4163
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4163
ucucacccag guagcaagga uua                                               23


<210> 4164
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4164
uuuugugucu cccauucccc ag                                                22


<210> 4165
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4165
cuggggaaug ggagacacaa aa                                                22


<210> 4166
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4166
agggggaugg cagagcaaaa uu                                                22


<210> 4167
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4167
aauuuugcuc ugccaucccc cu                                                22


<210> 4168
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4168
gugcauggcu guauauauaa ca                                                22


<210> 4169
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4169
uguuauauau acagccaugc ac                                                22


<210> 4170
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4170
uauauauaca gccaugcacu c                                                 21


<210> 4171
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4171
gagugcaugg cuguauauau a                                                 21


<210> 4172
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4172
aaugcacccg ggcaaggauu cu                                                22


<210> 4173
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4173
agaauccuug cccgggugca uu                                                22


<210> 4174
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4174
aauccuuugu cccuggguga ga                                                22


<210> 4175
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4175
ucucacccag ggacaaagga uu                                                22


<210> 4176
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4176
aaugcaccug ggcaaggauu ca                                                22


<210> 4177
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4177
ugaauccuug cccaggugca uu                                                22


<210> 4178
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4178
auccuugcua ucugggugcu a                                                 21


<210> 4179
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4179
uagcacccag auagcaagga u                                                 21


<210> 4180
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4180
agacccuggu cugcacucua uc                                                22


<210> 4181
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4181
gauagagugc agaccagggu cu                                                22


<210> 4182
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4182
uugcagcugc gguuguaagg u                                                 21


<210> 4183
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4183
accuuacaac cgcagcugca a                                                 21


<210> 4184
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4184
cgucaacacu ugcugguuuc cu                                                22


<210> 4185
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4185
aggaaaccag caaguguuga cg                                                22


<210> 4186
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4186
gggagccagg aaguauugau gu                                                22


<210> 4187
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4187
acaucaauac uuccuggcuc cc                                                22


<210> 4188
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4188
uaaggcaccc uucugaguag a                                                 21


<210> 4189
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4189
ucuacucaga agggugccuu a                                                 21


<210> 4190
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4190
uauucaggaa gguguuacuu aa                                                22


<210> 4191
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4191
uuaaguaaca ccuuccugaa ua                                                22


<210> 4192
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4192
uuuugcaccu uuuggaguga a                                                 21


<210> 4193
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4193
uucacuccaa aaggugcaaa a                                                 21


<210> 4194
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4194
ugauuguagc cuuuuggagu aga                                               23


<210> 4195
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4195
ucuacuccaa aaggcuacaa uca                                               23


<210> 4196
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4196
ggguuuguag cuuugcuggc aug                                               23


<210> 4197
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4197
caugccagca aagcuacaaa ccc                                               23


<210> 4198
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4198
cagggcucag ggauuggaug gag                                               23


<210> 4199
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4199
cuccauccaa ucccugagcc cug                                               23


<210> 4200
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4200
augcuacucg gaaaucccac uga                                               23


<210> 4201
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4201
ucagugggau uuccgaguag cau                                               23


<210> 4202
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4202
gugggauuuc ugaguagcau c                                                 21


<210> 4203
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4203
gaugcuacuc agaaauccca c                                                 21


<210> 4204
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4204
ccggggcaga uugguguagg gug                                               23


<210> 4205
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4205
cacccuacac caaucugccc cgg                                               23


<210> 4206
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4206
acggagacga caagacugug cug                                               23


<210> 4207
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4207
cagcacaguc uugucgucuc cgu                                               23


<210> 4208
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4208
aauccacgcu gagcuuggca uc                                                22


<210> 4209
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4209
gaugccaagc ucagcgugga uu                                                22


<210> 4210
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4210
aggaaaugag gcuggcuagg agc                                               23


<210> 4211
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4211
gcuccuagcc agccucauuu ccu                                               23


<210> 4212
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4212
ugauugguac gucugugggu ag                                                22


<210> 4213
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4213
cuacccacag acguaccaau ca                                                22


<210> 4214
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4214
aaucagugaa ugccuugaac cu                                                22


<210> 4215
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4215
agguucaagg cauucacuga uu                                                22


<210> 4216
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4216
uuacaggcgu gaaccaccgc g                                                 21


<210> 4217
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4217
cgcggugguu cacgccugua a                                                 21


<210> 4218
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4218
uacugcagac aguggcaauc a                                                 21


<210> 4219
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4219
ugauugccac ugucugcagu a                                                 21


<210> 4220
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4220
guuucaccau guuggucagg c                                                 21


<210> 4221
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4221
gccugaccaa cauggugaaa c                                                 21


<210> 4222
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4222
uaaauuucac cuuucugaga agg                                               23


<210> 4223
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4223
ccuucucaga aaggugaaau uua                                               23


<210> 4224
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4224
uucacaagga ggugucauuu au                                                22


<210> 4225
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4225
auaaaugaca ccuccuugug aa                                                22


<210> 4226
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4226
uaaauuucac cuuucugaga aga                                               23


<210> 4227
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4227
ucuucucaga aaggugaaau uua                                               23


<210> 4228
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4228
uucucaagga ggugucguuu au                                                22


<210> 4229
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4229
auaaacgaca ccuccuugag aa                                                22


<210> 4230
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4230
auugacacuu cugugaguag a                                                 21


<210> 4231
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4231
ucuacucaca gaagugucaa u                                                 21


<210> 4232
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4232
uacucuggag agugacaauc aug                                               23


<210> 4233
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4233
caugauuguc acucuccaga gua                                               23


<210> 4234
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4234
auugacaccu cugugagugg a                                                 21


<210> 4235
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4235
uccacucaca gaggugucaa u                                                 21


<210> 4236
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4236
uucucaagag ggaggcaauc au                                                22


<210> 4237
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4237
augauugccu cccucuugag aa                                                22


<210> 4238
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4238
gagugccuuc uuuuggagcg uu                                                22


<210> 4239
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4239
aacgcuccaa aagaaggcac uc                                                22


<210> 4240
<211> 18
<212> RNA
<213> Homo sapiens

<400> 4240
ugcuuccuuu cagagggu                                                     18


<210> 4241
<211> 18
<212> RNA
<213> Homo sapiens

<400> 4241
acccucugaa aggaagca                                                     18


<210> 4242
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4242
aucuggaggu aagaagcacu uu                                                22


<210> 4243
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4243
aaagugcuuc uuaccuccag au                                                22


<210> 4244
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4244
gaaagcgcuu cccuuugcug ga                                                22


<210> 4245
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4245
uccagcaaag ggaagcgcuu uc                                                22


<210> 4246
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4246
cugcaaaggg aagcccuuuc                                                   20


<210> 4247
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4247
gaaagggcuu cccuuugcag                                                   20


<210> 4248
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4248
caaagcgcuu cccuuuggag c                                                 21


<210> 4249
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4249
gcuccaaagg gaagcgcuuu g                                                 21


<210> 4250
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4250
cucuagaggg aagcacuuuc ug                                                22


<210> 4251
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4251
cagaaagugc uucccucuag ag                                                22


<210> 4252
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4252
aaagcgcuuc ccuucagagu g                                                 21


<210> 4253
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4253
cacucugaag ggaagcgcuu u                                                 21


<210> 4254
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4254
cucuagaggg aagcgcuuuc ug                                                22


<210> 4255
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4255
cagaaagcgc uucccucuag ag                                                22


<210> 4256
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4256
aaagugcauc cuuuuagagg uu                                                22


<210> 4257
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4257
aaccucuaaa aggaugcacu uu                                                22


<210> 4258
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4258
cucuagaggg aagcgcuuuc ug                                                22


<210> 4259
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4259
cagaaagcgc uucccucuag ag                                                22


<210> 4260
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4260
aaagugcauc uuuuuagagg au                                                22


<210> 4261
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4261
auccucuaaa aagaugcacu uu                                                22


<210> 4262
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4262
cucuagaggg aagcgcuuuc ug                                                22


<210> 4263
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4263
cagaaagcgc uucccucuag ag                                                22


<210> 4264
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4264
aaagugcuuc cuuuuagagg g                                                 21


<210> 4265
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4265
cccucuaaaa ggaagcacuu u                                                 21


<210> 4266
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4266
aaagugcuuc cuuuuagagg gu                                                22


<210> 4267
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4267
acccucuaaa aggaagcacu uu                                                22


<210> 4268
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4268
cucuagaggg aagcacuuuc ug                                                22


<210> 4269
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4269
cagaaagugc uucccucuag ag                                                22


<210> 4270
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4270
aaagugcuuc ucuuuggugg gu                                                22


<210> 4271
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4271
acccaccaaa gagaagcacu uu                                                22


<210> 4272
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4272
cuacaaaggg aagcccuuuc                                                   20


<210> 4273
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4273
gaaagggcuu cccuuuguag                                                   20


<210> 4274
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4274
aaagugcuuc cuuuuugagg g                                                 21


<210> 4275
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4275
cccucaaaaa ggaagcacuu u                                                 21


<210> 4276
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4276
aagugcuucc uuuuagaggg uu                                                22


<210> 4277
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4277
aacccucuaa aaggaagcac uu                                                22


<210> 4278
<211> 24
<212> RNA
<213> Homo sapiens

<400> 4278
acaaagugcu ucccuuuaga gugu                                              24


<210> 4279
<211> 24
<212> RNA
<213> Homo sapiens

<400> 4279
acacucuaaa gggaagcacu uugu                                              24


<210> 4280
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4280
aacgcacuuc ccuuuagagu gu                                                22


<210> 4281
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4281
acacucuaaa gggaagugcg uu                                                22


<210> 4282
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4282
aaaaugguuc ccuuuagagu gu                                                22


<210> 4283
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4283
acacucuaaa gggaaccauu uu                                                22


<210> 4284
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4284
cucuagaggg aagcgcuuuc ug                                                22


<210> 4285
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4285
cagaaagcgc uucccucuag ag                                                22


<210> 4286
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4286
gaacgcgcuu cccuauagag ggu                                               23


<210> 4287
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4287
acccucuaua gggaagcgcg uuc                                               23


<210> 4288
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4288
cucuagaggg aagcgcuuuc ug                                                22


<210> 4289
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4289
cagaaagcgc uucccucuag ag                                                22


<210> 4290
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4290
gaaggcgcuu cccuuuggag u                                                 21


<210> 4291
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4291
acuccaaagg gaagcgccuu c                                                 21


<210> 4292
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4292
cugcaaaggg aagcccuuuc                                                   20


<210> 4293
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4293
gaaagggcuu cccuuugcag                                                   20


<210> 4294
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4294
ccucccacac ccaaggcuug ca                                                22


<210> 4295
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4295
ugcaagccuu ggguguggga gg                                                22


<210> 4296
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4296
caugccuuga guguaggacc gu                                                22


<210> 4297
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4297
acgguccuac acucaaggca ug                                                22


<210> 4298
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4298
aucauacaag gacaauuucu uu                                                22


<210> 4299
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4299
aaagaaauug uccuuguaug au                                                22


<210> 4300
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4300
ggagaaauua uccuuggugu gu                                                22


<210> 4301
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4301
acacaccaag gauaauuucu cc                                                22


<210> 4302
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4302
uggugggcac agaaucugga cu                                                22


<210> 4303
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4303
aguccagauu cugugcccac ca                                                22


<210> 4304
<211> 25
<212> RNA
<213> Homo sapiens

<400> 4304
aaaggauucu gcugucgguc ccacu                                             25


<210> 4305
<211> 25
<212> RNA
<213> Homo sapiens

<400> 4305
agugggaccg acagcagaau ccuuu                                             25


<210> 4306
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4306
ucggggauca ucaugucacg aga                                               23


<210> 4307
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4307
ucucgugaca ugaugauccc cga                                               23


<210> 4308
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4308
aaacauucgc ggugcacuuc uu                                                22


<210> 4309
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4309
aagaagugca ccgcgaaugu uu                                                22


<210> 4310
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4310
auucugcauu uuuagcaagu uc                                                22


<210> 4311
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4311
gaacuugcua aaaaugcaga au                                                22


<210> 4312
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4312
accugagguu gugcauuucu aa                                                22


<210> 4313
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4313
uuagaaaugc acaaccucag gu                                                22


<210> 4314
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4314
ucagcaaaca uuuauugugu gc                                                22


<210> 4315
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4315
gcacacaaua aauguuugcu ga                                                22


<210> 4316
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4316
ucaguaaaug uuuauuagau ga                                                22


<210> 4317
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4317
ucaucuaaua aacauuuacu ga                                                22


<210> 4318
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4318
agcuacaguu acuuuugcac ca                                                22


<210> 4319
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4319
uggugcaaaa guaacuguag cu                                                22


<210> 4320
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4320
uaaaaacugc aauuacuuuc                                                   20


<210> 4321
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4321
gaaaguaauu gcaguuuuua                                                   20


<210> 4322
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4322
ugcaaaagua auugcaguuu uug                                               23


<210> 4323
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4323
caaaaacugc aauuacuuuu gca                                               23


<210> 4324
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4324
aaagaccgug acuacuuuug ca                                                22


<210> 4325
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4325
ugcaaaagua gucacggucu uu                                                22


<210> 4326
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4326
agaaguaacu acgguuuuug ca                                                22


<210> 4327
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4327
ugcaaaaacc guaguuacuu cu                                                22


<210> 4328
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4328
aaaaaccaca auuacuuuu                                                    19


<210> 4329
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4329
aaaaguaauu gugguuuuu                                                    19


<210> 4330
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4330
aaaaguaauu gcggucuuu                                                    19


<210> 4331
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4331
aaagaccgca auuacuuuu                                                    19


<210> 4332
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4332
caaaaacugc aauuacuuuu gc                                                22


<210> 4333
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4333
gcaaaaguaa uugcaguuuu ug                                                22


<210> 4334
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4334
gaaaguaauu gcuguuuuug cc                                                22


<210> 4335
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4335
ggcaaaaaca gcaauuacuu uc                                                22


<210> 4336
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4336
uaaaacugca guuauuuuug c                                                 21


<210> 4337
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4337
gcaaaaauaa cugcaguuuu a                                                 21


<210> 4338
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4338
aaaaguaauu gcaguuuuug c                                                 21


<210> 4339
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4339
gcaaaaacug caauuacuuu u                                                 21


<210> 4340
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4340
uaaaacccac aauuauguuu gu                                                22


<210> 4341
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4341
acaaacauaa uuguggguuu ua                                                22


<210> 4342
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4342
aaaaguaauu gcggguuuug cc                                                22


<210> 4343
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4343
ggcaaaaccc gcaauuacuu uu                                                22


<210> 4344
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4344
caaaaccgca guaacuuuug u                                                 21


<210> 4345
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4345
acaaaaguua cugcgguuuu g                                                 21


<210> 4346
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4346
aaaaguuauu gcgguuuugg cu                                                22


<210> 4347
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4347
agccaaaacc gcaauaacuu uu                                                22


<210> 4348
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4348
uggcaguuac uuuugcacca g                                                 21


<210> 4349
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4349
cuggugcaaa aguaacugcc a                                                 21


<210> 4350
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4350
aaaaguaauu gcgguuuuug c                                                 21


<210> 4351
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4351
gcaaaaaccg caauuacuuu u                                                 21


<210> 4352
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4352
aaaacugcag uuacuuuugc                                                   20


<210> 4353
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4353
gcaaaaguaa cugcaguuuu                                                   20


<210> 4354
<211> 18
<212> RNA
<213> Homo sapiens

<400> 4354
aaaaguacuu gcggauuu                                                     18


<210> 4355
<211> 18
<212> RNA
<213> Homo sapiens

<400> 4355
aaauccgcaa guacuuuu                                                     18


<210> 4356
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4356
gugcaaaagu caucacgguu                                                   20


<210> 4357
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4357
aaccgugaug acuuuugcac                                                   20


<210> 4358
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4358
gcuggugcaa aaguaauggc gg                                                22


<210> 4359
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4359
ccgccauuac uuuugcacca gc                                                22


<210> 4360
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4360
aaaaguaauc acuguuuuug cc                                                22


<210> 4361
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4361
ggcaaaaaca gugauuacuu uu                                                22


<210> 4362
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4362
agugccugag ggaguaagag                                                   20


<210> 4363
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4363
cucuuacucc cucaggcacu                                                   20


<210> 4364
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4364
ugucuuacuc ccucaggcac au                                                22


<210> 4365
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4365
augugccuga gggaguaaga ca                                                22


<210> 4366
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4366
agugccugag ggaguaagag ccc                                               23


<210> 4367
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4367
gggcucuuac ucccucaggc acu                                               23


<210> 4368
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4368
gcgacccacu cuugguuucc a                                                 21


<210> 4369
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4369
uggaaaccaa gagugggucg c                                                 21


<210> 4370
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4370
uuagcuuaag gaguaccaga uc                                                22


<210> 4371
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4371
gaucugguac uccuuaagcu aa                                                22


<210> 4372
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4372
uaugguacuc cuuaagcuaa c                                                 21


<210> 4373
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4373
guuagcuuaa ggaguaccau a                                                 21


<210> 4374
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4374
ugagcugcug uaccaaaau                                                    19


<210> 4375
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4375
auuuugguac agcagcuca                                                    19


<210> 4376
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4376
cacauaugaa gugagccagc ac                                                22


<210> 4377
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4377
gugcuggcuc acuucauaug ug                                                22


<210> 4378
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4378
ugcuggcuca uuucauaugu gu                                                22


<210> 4379
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4379
acacauauga aaugagccag ca                                                22


<210> 4380
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4380
uuccaugccu ccuagaaguu cc                                                22


<210> 4381
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4381
ggaacuucua ggaggcaugg aa                                                22


<210> 4382
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4382
agccuuccag gagaaaugga ga                                                22


<210> 4383
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4383
ucuccauuuc uccuggaagg cu                                                22


<210> 4384
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4384
uaaaacuuua agugugccua gg                                                22


<210> 4385
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4385
ccuaggcaca cuuaaaguuu ua                                                22


<210> 4386
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4386
uaggcacacu uaaaguuaua gc                                                22


<210> 4387
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4387
gcuauaacuu uaagugugcc ua                                                22


<210> 4388
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4388
gaauaugggu auauuaguuu gg                                                22


<210> 4389
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4389
ccaaacuaau auacccauau uc                                                22


<210> 4390
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4390
aaacuaauau acccauauuc ug                                                22


<210> 4391
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4391
cagaauaugg guauauuagu uu                                                22


<210> 4392
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4392
uaguucuucc cuuugcccaa uu                                                22


<210> 4393
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4393
aauugggcaa agggaagaac ua                                                22


<210> 4394
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4394
cagggaaaug ggaagaacua ga                                                22


<210> 4395
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4395
ucuaguucuu cccauuuccc ug                                                22


<210> 4396
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4396
cugaauagcu gggacuacag gu                                                22


<210> 4397
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4397
accuguaguc ccagcuauuc ag                                                22


<210> 4398
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4398
ugaaguacca gcuacucgag ag                                                22


<210> 4399
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4399
cucucgagua gcugguacuu ca                                                22


<210> 4400
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4400
cagagugaca agcugguuaa ag                                                22


<210> 4401
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4401
cuuuaaccag cuugucacuc ug                                                22


<210> 4402
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4402
uauccagcuu guuacuauau gc                                                22


<210> 4403
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4403
gcauauagua acaagcugga ua                                                22


<210> 4404
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4404
gccccgggca gugugaucau c                                                 21


<210> 4405
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4405
gaugaucaca cugcccgggg c                                                 21


<210> 4406
<211> 18
<212> RNA
<213> Homo sapiens

<400> 4406
auggucaccu ccgggacu                                                     18


<210> 4407
<211> 18
<212> RNA
<213> Homo sapiens

<400> 4407
agucccggag gugaccau                                                     18


<210> 4408
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4408
aagucccacu aaugccagc                                                    19


<210> 4409
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4409
gcuggcauua gugggacuu                                                    19


<210> 4410
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4410
acuggcauua gugggacuuu u                                                 21


<210> 4411
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4411
aaaaguccca cuaaugccag u                                                 21


<210> 4412
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4412
ugcacauggc aaccuagcuc cca                                               23


<210> 4413
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4413
ugggagcuag guugccaugu gca                                               23


<210> 4414
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4414
ggcugggugc ucuugugcag u                                                 21


<210> 4415
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4415
acugcacaag agcacccagc c                                                 21


<210> 4416
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4416
uaaaguaaau augcaccaaa a                                                 21


<210> 4417
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4417
uuuuggugca uauuuacuuu a                                                 21


<210> 4418
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4418
aauaaaguuc auguauggca a                                                 21


<210> 4419
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4419
uugccauaca ugaacuuuau u                                                 21


<210> 4420
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4420
uugccauaca uagacuuuau u                                                 21


<210> 4421
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4421
aauaaagucu auguauggca a                                                 21


<210> 4422
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4422
auacccauag cuuagcuccc a                                                 21


<210> 4423
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4423
ugggagcuaa gcuaugggua u                                                 21


<210> 4424
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4424
ugggagcuaa gcuaugggua u                                                 21


<210> 4425
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4425
auacccauag cuuagcuccc a                                                 21


<210> 4426
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4426
caaaguuuaa gauccuugaa gu                                                22


<210> 4427
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4427
acuucaagga ucuuaaacuu ug                                                22


<210> 4428
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4428
aucaaggauc uuaaacuuug cc                                                22


<210> 4429
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4429
ggcaaaguuu aagauccuug au                                                22


<210> 4430
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4430
aaaguagcug uaccauuugc                                                   20


<210> 4431
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4431
gcaaauggua cagcuacuuu                                                   20


<210> 4432
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4432
aggcacggug ucagcaggc                                                    19


<210> 4433
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4433
gccugcugac accgugccu                                                    19


<210> 4434
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4434
gggcgccugu gaucccaac                                                    19


<210> 4435
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4435
guugggauca caggcgccc                                                    19


<210> 4436
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4436
aguauguucu uccaggacag aac                                               23


<210> 4437
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4437
guucuguccu ggaagaacau acu                                               23


<210> 4438
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4438
gagaaaugcu ggacuaaucu gc                                                22


<210> 4439
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4439
gcagauuagu ccagcauuuc uc                                                22


<210> 4440
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4440
agaaagggug gcaauaccuc uu                                                22


<210> 4441
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4441
aagagguauu gccacccuuu cu                                                22


<210> 4442
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4442
agguauugcc acccuuucua gu                                                22


<210> 4443
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4443
acuagaaagg guggcaauac cu                                                22


<210> 4444
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4444
guagcaccuu gcaggauaag gu                                                22


<210> 4445
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4445
accuuauccu gcaaggugcu ac                                                22


<210> 4446
<211> 24
<212> RNA
<213> Homo sapiens

<400> 4446
uacagaugca gauucucuga cuuc                                              24


<210> 4447
<211> 24
<212> RNA
<213> Homo sapiens

<400> 4447
gaagucagag aaucugcauc ugua                                              24


<210> 4448
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4448
aacucuagcc ugagcaacag                                                   20


<210> 4449
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4449
cuguugcuca ggcuagaguu                                                   20


<210> 4450
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4450
acagcccagc aguuaucacg gg                                                22


<210> 4451
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4451
cccgugauaa cugcugggcu gu                                                22


<210> 4452
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4452
uaucguaucg uauuguauug u                                                 21


<210> 4453
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4453
acaauacaau acgauacgau a                                                 21


<210> 4454
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4454
uuagaacguu uuagggucaa au                                                22


<210> 4455
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4455
auuugacccu aaaacguucu aa                                                22


<210> 4456
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4456
uaacaaacac cuguaaaaca gc                                                22


<210> 4457
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4457
gcuguuuuac agguguuugu ua                                                22


<210> 4458
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4458
agcauacacc uguaguccua ga                                                22


<210> 4459
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4459
ucuaggacua cagguguaug cu                                                22


<210> 4460
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4460
aguuaaugaa uccuggaaag u                                                 21


<210> 4461
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4461
acuuuccagg auucauuaac u                                                 21


<210> 4462
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4462
ucagcuacua ccucuauuag g                                                 21


<210> 4463
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4463
ccuaauagag guaguagcug a                                                 21


<210> 4464
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4464
uugcucugag cuccgagaaa gc                                                22


<210> 4465
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4465
gcuuucucgg agcucagagc aa                                                22


<210> 4466
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4466
caaauaauac cacagugggu gu                                                22


<210> 4467
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4467
acacccacug ugguauuauu ug                                                22


<210> 4468
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4468
aauaauauca caguaggugu                                                   20


<210> 4469
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4469
acaccuacug ugauauuauu                                                   20


<210> 4470
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4470
aauaauauca caguaggugu ac                                                22


<210> 4471
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4471
guacaccuac ugugauauua uu                                                22


<210> 4472
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4472
gcaguggcuc ugaaaugaac uc                                                22


<210> 4473
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4473
gaguucauuu cagagccacu gc                                                22


<210> 4474
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4474
cagaucaugg gacugucuca g                                                 21


<210> 4475
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4475
cugagacagu cccaugaucu g                                                 21


<210> 4476
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4476
acuccaagaa gaaucuagac ag                                                22


<210> 4477
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4477
cugucuagau ucuucuugga gu                                                22


<210> 4478
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4478
cucauuuaag uagucugaug cc                                                22


<210> 4479
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4479
ggcaucagac uacuuaaaug ag                                                22


<210> 4480
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4480
ucaaguaguu ucaugauaaa gg                                                22


<210> 4481
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4481
ccuuuaucau gaaacuacuu ga                                                22


<210> 4482
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4482
ugggggagug cagugauugu gg                                                22


<210> 4483
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4483
ccacaaucac ugcacucccc ca                                                22


<210> 4484
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4484
uccugucuuu ccuuguugga gc                                                22


<210> 4485
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4485
gcuccaacaa ggaaagacag ga                                                22


<210> 4486
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4486
uaaugcauua aauuauugaa gg                                                22


<210> 4487
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4487
ccuucaauaa uuuaaugcau ua                                                22


<210> 4488
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4488
uuauugucac guucugauu                                                    19


<210> 4489
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4489
aaucagaacg ugacaauaa                                                    19


<210> 4490
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4490
ugagucagca acauauccca ug                                                22


<210> 4491
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4491
caugggauau guugcugacu ca                                                22


<210> 4492
<211> 18
<212> RNA
<213> Homo sapiens

<400> 4492
aggagaaguc gggaaggu                                                     18


<210> 4493
<211> 18
<212> RNA
<213> Homo sapiens

<400> 4493
accuucccga cuucuccu                                                     18


<210> 4494
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4494
cgaaaacagc aauuaccuuu gc                                                22


<210> 4495
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4495
gcaaagguaa uugcuguuuu cg                                                22


<210> 4496
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4496
uuaggccauc aucccauuau gc                                                22


<210> 4497
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4497
gcauaauggg augauggccu aa                                                22


<210> 4498
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4498
uguuucgggg cucauggccu gug                                               23


<210> 4499
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4499
cacaggccau gagccccgaa aca                                               23


<210> 4500
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4500
aaagguaauu gcaguuuuuc cc                                                22


<210> 4501
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4501
gggaaaaacu gcaauuaccu uu                                                22


<210> 4502
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4502
uucuggauaa caugcugaag cu                                                22


<210> 4503
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4503
agcuucagca uguuauccag aa                                                22


<210> 4504
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4504
acguuugaau gcuguacaag gc                                                22


<210> 4505
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4505
gccuuguaca gcauucaaac gu                                                22


<210> 4506
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4506
augagcgacu gugccugacc                                                   20


<210> 4507
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4507
ggucaggcac agucgcucau                                                   20


<210> 4508
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4508
gagccaguug gacaggagc                                                    19


<210> 4509
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4509
gcuccugucc aacuggcuc                                                    19


<210> 4510
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4510
uucauuuggu auaaaccgcg auu                                               23


<210> 4511
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4511
aaucgcgguu uauaccaaau gaa                                               23


<210> 4512
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4512
uugagaauga ugaaucauua gg                                                22


<210> 4513
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4513
ccuaaugauu caucauucuc aa                                                22


<210> 4514
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4514
uuacaguugu ucaaccaguu acu                                               23


<210> 4515
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4515
aguaacuggu ugaacaacug uaa                                               23


<210> 4516
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4516
caaagaggaa ggucccauua c                                                 21


<210> 4517
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4517
guaaugggac cuuccucuuu g                                                 21


<210> 4518
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4518
ucaguuccag gccaaccagg cu                                                22


<210> 4519
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4519
agccugguug gccuggaacu ga                                                22


<210> 4520
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4520
uuaugguuug ccugggacug ag                                                22


<210> 4521
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4521
cucaguccca ggcaaaccau aa                                                22


<210> 4522
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4522
ugggcguauc uguaugcua                                                    19


<210> 4523
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4523
uagcauacag auacgccca                                                    19


<210> 4524
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4524
agaccauggg uucucauugu                                                   20


<210> 4525
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4525
acaaugagaa cccauggucu                                                   20


<210> 4526
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4526
uugugucaau augcgaugau gu                                                22


<210> 4527
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4527
acaucaucgc auauugacac aa                                                22


<210> 4528
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4528
ugucucugcu gggguuucu                                                    19


<210> 4529
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4529
agaaacccca gcagagaca                                                    19


<210> 4530
<211> 25
<212> RNA
<213> Homo sapiens

<400> 4530
aggcaccagc caggcauugc ucagc                                             25


<210> 4531
<211> 25
<212> RNA
<213> Homo sapiens

<400> 4531
gcugagcaau gccuggcugg ugccu                                             25


<210> 4532
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4532
gaagugugcc gugguguguc u                                                 21


<210> 4533
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4533
agacacacca cggcacacuu c                                                 21


<210> 4534
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4534
aagccugccc ggcuccucgg g                                                 21


<210> 4535
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4535
cccgaggagc cgggcaggcu u                                                 21


<210> 4536
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4536
guugugucag uuuaucaaac                                                   20


<210> 4537
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4537
guuugauaaa cugacacaac                                                   20


<210> 4538
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4538
uggucuagga uuguuggagg ag                                                22


<210> 4539
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4539
cuccuccaac aauccuagac ca                                                22


<210> 4540
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4540
cacacacugc aauuacuuuu gc                                                22


<210> 4541
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4541
gcaaaaguaa uugcagugug ug                                                22


<210> 4542
<211> 25
<212> RNA
<213> Homo sapiens

<400> 4542
agggguggug uugggacagc uccgu                                             25


<210> 4543
<211> 25
<212> RNA
<213> Homo sapiens

<400> 4543
acggagcugu cccaacacca ccccu                                             25


<210> 4544
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4544
ugagcuaaau gugugcuggg a                                                 21


<210> 4545
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4545
ucccagcaca cauuuagcuc a                                                 21


<210> 4546
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4546
gcgaggaccc cucggggucu gac                                               23


<210> 4547
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4547
gucagacccc gagggguccu cgc                                               23


<210> 4548
<211> 25
<212> RNA
<213> Homo sapiens

<400> 4548
gcugggcagg gcuucugagc uccuu                                             25


<210> 4549
<211> 25
<212> RNA
<213> Homo sapiens

<400> 4549
aaggagcuca gaagcccugc ccagc                                             25


<210> 4550
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4550
gggaaaagga agggggagga                                                   20


<210> 4551
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4551
uccucccccu uccuuuuccc                                                   20


<210> 4552
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4552
gcggaaggcg gagcggcgga                                                   20


<210> 4553
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4553
uccgccgcuc cgccuuccgc                                                   20


<210> 4554
<211> 18
<212> RNA
<213> Homo sapiens

<400> 4554
gugaaggccc ggcggaga                                                     18


<210> 4555
<211> 18
<212> RNA
<213> Homo sapiens

<400> 4555
ucuccgccgg gccuucac                                                     18


<210> 4556
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4556
ugagggagug ggugggagg                                                    19


<210> 4557
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4557
ccucccaccc acucccuca                                                    19


<210> 4558
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4558
acuggaauug gagucaaaa                                                    19


<210> 4559
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4559
uuuugacucc aauuccagu                                                    19


<210> 4560
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4560
ugagggaguu ggguguaua                                                    19


<210> 4561
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4561
uauacaccca acucccuca                                                    19


<210> 4562
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4562
ugagggagug gauuguaug                                                    19


<210> 4563
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4563
cauacaaucc acucccuca                                                    19


<210> 4564
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4564
ggcuggucag augggagug                                                    19


<210> 4565
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4565
cacucccauc ugaccagcc                                                    19


<210> 4566
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4566
agcagggcug gggauugca                                                    19


<210> 4567
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4567
ugcaaucccc agcccugcu                                                    19


<210> 4568
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4568
ugagggagga gguugggua                                                    19


<210> 4569
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4569
uacccaaccu ccucccuca                                                    19


<210> 4570
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4570
ugagguggua ggauguaga                                                    19


<210> 4571
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4571
ucuacauccu accaccuca                                                    19


<210> 4572
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4572
uccgagccug ggucucccuc uu                                                22


<210> 4573
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4573
aagagggaga cccaggcucg ga                                                22


<210> 4574
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4574
gggggucccc ggugcucgga uc                                                22


<210> 4575
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4575
gauccgagca ccggggaccc cc                                                22


<210> 4576
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4576
agucauugga ggguuugagc ag                                                22


<210> 4577
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4577
cugcucaaac ccuccaauga cu                                                22


<210> 4578
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4578
cagcaggagg ugaggggag                                                    19


<210> 4579
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4579
cuccccucac cuccugcug                                                    19


<210> 4580
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4580
acucaaaacc cuucagugac uu                                                22


<210> 4581
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4581
aagucacuga aggguuuuga gu                                                22


<210> 4582
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4582
agacuuccca uuugaaggug gc                                                22


<210> 4583
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4583
gccaccuuca aaugggaagu cu                                                22


<210> 4584
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4584
aaacucuacu uguccuucug agu                                               23


<210> 4585
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4585
acucagaagg acaaguagag uuu                                               23


<210> 4586
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4586
ggcuagcaac agcgcuuacc u                                                 21


<210> 4587
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4587
agguaagcgc uguugcuagc c                                                 21


<210> 4588
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4588
acagucugcu gagguuggag c                                                 21


<210> 4589
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4589
gcuccaaccu cagcagacug u                                                 21


<210> 4590
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4590
aucccuugca ggggcuguug ggu                                               23


<210> 4591
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4591
acccaacagc cccugcaagg gau                                               23


<210> 4592
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4592
gugagucucu aagaaaagag ga                                                22


<210> 4593
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4593
uccucuuuuc uuagagacuc ac                                                22


<210> 4594
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4594
ucuaguaaga guggcagucg a                                                 21


<210> 4595
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4595
ucgacugcca cucuuacuag a                                                 21


<210> 4596
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4596
augcugacau auuuacuaga gg                                                22


<210> 4597
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4597
ccucuaguaa auaugucagc au                                                22


<210> 4598
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4598
guucucccaa cguaagccca gc                                                22


<210> 4599
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4599
gcugggcuua cguugggaga ac                                                22


<210> 4600
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4600
uggguuuacg uugggagaac u                                                 21


<210> 4601
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4601
aguucuccca acguaaaccc a                                                 21


<210> 4602
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4602
gugucugcuu ccuguggga                                                    19


<210> 4603
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4603
ucccacagga agcagacac                                                    19


<210> 4604
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4604
cuaauaguau cuaccacaau aaa                                               23


<210> 4605
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4605
uuuauugugg uagauacuau uag                                               23


<210> 4606
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4606
ugugcuugcu cgucccgccc gca                                               23


<210> 4607
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4607
ugcgggcggg acgagcaagc aca                                               23


<210> 4608
<211> 25
<212> RNA
<213> Homo sapiens

<400> 4608
agggaucgcg ggcggguggc ggccu                                             25


<210> 4609
<211> 25
<212> RNA
<213> Homo sapiens

<400> 4609
aggccgccac ccgcccgcga ucccu                                             25


<210> 4610
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4610
augauccagg aaccugccuc u                                                 21


<210> 4611
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4611
agaggcaggu uccuggauca u                                                 21


<210> 4612
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4612
aguguggcuu ucuuagagc                                                    19


<210> 4613
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4613
gcucuaagaa agccacacu                                                    19


<210> 4614
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4614
ucuaggcugg uacugcuga                                                    19


<210> 4615
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4615
ucagcaguac cagccuaga                                                    19


<210> 4616
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4616
aagcagcugc cucugaggc                                                    19


<210> 4617
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4617
gccucagagg cagcugcuu                                                    19


<210> 4618
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4618
guggcugcac ucacuuccuu c                                                 21


<210> 4619
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4619
gaaggaagug agugcagcca c                                                 21


<210> 4620
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4620
aggaggcagc gcucucagga c                                                 21


<210> 4621
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4621
guccugagag cgcugccucc u                                                 21


<210> 4622
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4622
aauggcgcca cuaggguugu g                                                 21


<210> 4623
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4623
cacaacccua guggcgccau u                                                 21


<210> 4624
<211> 25
<212> RNA
<213> Homo sapiens

<400> 4624
caacccuagg agagggugcc auuca                                             25


<210> 4625
<211> 25
<212> RNA
<213> Homo sapiens

<400> 4625
ugaauggcac ccucuccuag gguug                                             25


<210> 4626
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4626
auaauacaug guuaaccucu uu                                                22


<210> 4627
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4627
aaagagguua accauguauu au                                                22


<210> 4628
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4628
aauauuauac agucaaccuc u                                                 21


<210> 4629
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4629
agagguugac uguauaauau u                                                 21


<210> 4630
<211> 25
<212> RNA
<213> Homo sapiens

<400> 4630
ggcggaggga aguagguccg uuggu                                             25


<210> 4631
<211> 25
<212> RNA
<213> Homo sapiens

<400> 4631
accaacggac cuacuucccu ccgcc                                             25


<210> 4632
<211> 24
<212> RNA
<213> Homo sapiens

<400> 4632
ugccuggguc ucuggccugc gcgu                                              24


<210> 4633
<211> 24
<212> RNA
<213> Homo sapiens

<400> 4633
acgcgcaggc cagagaccca ggca                                              24


<210> 4634
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4634
aggcggggcg ccgcgggacc gc                                                22


<210> 4635
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4635
gcggucccgc ggcgccccgc cu                                                22


<210> 4636
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4636
gguggcccgg ccgugccuga gg                                                22


<210> 4637
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4637
ccucaggcac ggccgggcca cc                                                22


<210> 4638
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4638
accaggaggc ugaggccccu                                                   20


<210> 4639
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4639
aggggccuca gccuccuggu                                                   20


<210> 4640
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4640
gucccugagu guauguggug                                                   20


<210> 4641
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4641
caccacauac acucagggac                                                   20


<210> 4642
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4642
uccgguucuc agggcuccac c                                                 21


<210> 4643
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4643
gguggagccc ugagaaccgg a                                                 21


<210> 4644
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4644
aggaagcccu ggaggggcug gag                                               23


<210> 4645
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4645
cuccagcccc uccagggcuu ccu                                               23


<210> 4646
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4646
cuguaugccc ucaccgcuca                                                   20


<210> 4647
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4647
ugagcgguga gggcauacag                                                   20


<210> 4648
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4648
uggugcggag agggcccaca gug                                               23


<210> 4649
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4649
cacugugggc ccucuccgca cca                                               23


<210> 4650
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4650
caacuagacu gugagcuucu ag                                                22


<210> 4651
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4651
cuagaagcuc acagucuagu ug                                                22


<210> 4652
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4652
aaggagcuua caaucuagcu ggg                                               23


<210> 4653
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4653
cccagcuaga uuguaagcuc cuu                                               23


<210> 4654
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4654
gggacccagg gagagacgua ag                                                22


<210> 4655
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4655
cuuacgucuc ucccuggguc cc                                                22


<210> 4656
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4656
gcagagugca aacaauuuug ac                                                22


<210> 4657
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4657
gucaaaauug uuugcacucu gc                                                22


<210> 4658
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4658
cggcucuggg ucugugggga                                                   20


<210> 4659
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4659
uccccacaga cccagagccg                                                   20


<210> 4660
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4660
gcagcagggu gaaacugaca ca                                                22


<210> 4661
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4661
ugugucaguu ucacccugcu gc                                                22


<210> 4662
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4662
uggaggagaa ggaaggugau g                                                 21


<210> 4663
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4663
caucaccuuc cuucuccucc a                                                 21


<210> 4664
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4664
ucugcucaua ccccaugguu ucu                                               23


<210> 4665
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4665
agaaaccaug ggguaugagc aga                                               23


<210> 4666
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4666
ugcaccaugg uugucugagc aug                                               23


<210> 4667
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4667
caugcucaga caaccauggu gca                                               23


<210> 4668
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4668
cugggaucuc cggggucuug guu                                               23


<210> 4669
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4669
aaccaagacc ccggagaucc cag                                               23


<210> 4670
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4670
ugagaccucu ggguucugag cu                                                22


<210> 4671
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4671
agcucagaac ccagaggucu ca                                                22


<210> 4672
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4672
uccaguacca cgugucaggg cca                                               23


<210> 4673
<211> 23
<212> RNA
<213> Homo sapiens

<400> 4673
uggcccugac acgugguacu gga                                               23


<210> 4674
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4674
ggagacugau gaguucccgg ga                                                22


<210> 4675
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4675
ucccgggaac ucaucagucu cc                                                22


<210> 4676
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4676
gcaggaacuu gugagucucc u                                                 21


<210> 4677
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4677
aggagacuca caaguuccug c                                                 21


<210> 4678
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4678
cugcccuggc ccgagggacc ga                                                22


<210> 4679
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4679
ucggucccuc gggccagggc ag                                                22


<210> 4680
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4680
ccuggaaaca cugagguugu g                                                 21


<210> 4681
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4681
cacaaccuca guguuuccag g                                                 21


<210> 4682
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4682
uauaccucag uuuuaucagg ug                                                22


<210> 4683
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4683
caccugauaa aacugaggua ua                                                22


<210> 4684
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4684
uggugguuua caaaguaauu ca                                                22


<210> 4685
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4685
ugaauuacuu uguaaaccac ca                                                22


<210> 4686
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4686
uggauuucuu ugugaaucac ca                                                22


<210> 4687
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4687
uggugauuca caaagaaauc ca                                                22


<210> 4688
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4688
uccucuucuc ccuccuccca g                                                 21


<210> 4689
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4689
cugggaggag ggagaagagg a                                                 21


<210> 4690
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4690
guagaggaga uggcgcaggg                                                   20


<210> 4691
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4691
cccugcgcca ucuccucuac                                                   20


<210> 4692
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4692
gugaacgggc gccaucccga gg                                                22


<210> 4693
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4693
ccucgggaug gcgcccguuc ac                                                22


<210> 4694
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4694
gacugacacc ucuuugggug aa                                                22


<210> 4695
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4695
uucacccaaa gaggugucag uc                                                22


<210> 4696
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4696
uacucaaaaa gcugucaguc a                                                 21


<210> 4697
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4697
ugacugacag cuuuuugagu a                                                 21


<210> 4698
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4698
uuaauaucgg acaaccauug u                                                 21


<210> 4699
<211> 21
<212> RNA
<213> Homo sapiens

<400> 4699
acaaugguug uccgauauua a                                                 21


<210> 4700
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4700
auccgcgcuc ugacucucug cc                                                22


<210> 4701
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4701
ggcagagagu cagagcgcgg au                                                22


<210> 4702
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4702
gugagucagg guggggcugg                                                   20


<210> 4703
<211> 20
<212> RNA
<213> Homo sapiens

<400> 4703
ccagccccac ccugacucac                                                   20


<210> 4704
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4704
ugcccuuaaa ggugaaccca gu                                                22


<210> 4705
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4705
acuggguuca ccuuuaaggg ca                                                22


<210> 4706
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4706
ucuucucugu uuuggccaug ug                                                22


<210> 4707
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4707
cacauggcca aaacagagaa ga                                                22


<210> 4708
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4708
aaauuauugu acaucggaug ag                                                22


<210> 4709
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4709
cucauccgau guacaauaau uu                                                22


<210> 4710
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4710
uucaacgggu auuuauugag ca                                                22


<210> 4711
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4711
ugcucaauaa auacccguug aa                                                22


<210> 4712
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4712
cuauacaacu uacuacuuuc cc                                                22


<210> 4713
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4713
gggaaaguag uaaguuguau ag                                                22


<210> 4714
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4714
ugagguagua aguuguauug uu                                                22


<210> 4715
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4715
aacaauacaa cuuacuaccu ca                                                22


<210> 4716

<400> 4716
000


<210> 4717

<400> 4717
000


<210> 4718

<400> 4718
000


<210> 4719

<400> 4719
000


<210> 4720

<400> 4720
000


<210> 4721

<400> 4721
000


<210> 4722

<400> 4722
000


<210> 4723

<400> 4723
000


<210> 4724

<400> 4724
000


<210> 4725

<400> 4725
000


<210> 4726

<400> 4726
000


<210> 4727

<400> 4727
000


<210> 4728

<400> 4728
000


<210> 4729

<400> 4729
000


<210> 4730

<400> 4730
000


<210> 4731

<400> 4731
000


<210> 4732

<400> 4732
000


<210> 4733

<400> 4733
000


<210> 4734
<211> 3131
<212> DNA
<213> Adeno-associated virus

<400> 4734
gcggccgcga attcgccctt ggctgcgtca actggaccaa tgagaacttt cccttcaatg       60

attgcgtcga caagatggtg atctggtggg aggagggcaa gatgacggcc aaggtcgtgg      120

agtccgccaa ggccattctc ggcggcagca aggtgcgcgt ggaccaaaag tgcaagtcgt      180

ccgcccagat cgaccccacc cccgtgatcg tcacctccaa caccaacatg tgcgccgtga      240

ttgacgggaa cagcaccacc ttcgagcacc agcagcctct ccaggaccgg atgtttaagt      300

tcgaactcac ccgccgtctg gagcacgact ttggcaaggt gacaaagcag gaagtcaaag      360

agttcttccg ctgggccagt gatcacgtga ccgaggtggc gcatgagttt tacgtcagaa      420

agggcggagc cagcaaaaga cccgcccccg atgacgcgga taaaagcgag cccaagcggg      480

cctgcccctc agtcgcggat ccatcgacgt cagacgcgga aggagctccg gtggactttg      540

ccgacaggta ccaaaacaaa tgttctcgtc acgcgggcat gcttcagatg ctgtttccct      600

gcaaaacgtg cgagagaatg aatcggaatt tcaacatttg cttcacacac ggggtcagag      660

actgctcaga gtgtttcccc ggcgtgtcag aatctcaacc ggtcgtcaga aagaggacgt      720

atcggaaact ccgtgcgatt catcatctgc tggggcgggc tcccgagatt gcttgctcgg      780

cctgcgatct ggtcaacgtg gacctggatg actgtgtttc tgagcaataa atgacttaaa      840

ccaggtatgg ctgccgatgg ttatcttcca gattggctcg aggacaacct ctctgagggc      900

attcgcgagt ggtgggcgct gaaacctgga gccccgaagc ccaaagccaa ccagcaaaag      960

caggacgacg gccggggtct ggtgcttcct ggctacaagt acctcggacc cttcaacgga     1020

ctcgacaagg gggagcccgt caacgcggcg gacgcagcgg ccctcgagca cgacaaggct     1080

tacgaccagc agctgcaggc gggtgacaat ccgtacctgc ggtataacca cgccgacgcc     1140

gagtttcagg agcgtctgca agaagatacg tcttttgggg gcaacctcgg gcgagcagtc     1200

ttccaggcca agaagcgggt tctcgaacct ctcggtctgg ttgaggaagg cgctaagacg     1260

gctcctggaa agaagagacc ggtagagcca tcaccccagc gttctccaga ctcctctacg     1320

ggcatcggca agaaaggcca acagcccgcc agaaaaagac tcaattttgg tcagactggc     1380

gactcagagt cagttccaga ccctcaacct ctcggagaac ctccagcagc gccctctggt     1440

gtgggaccta atacaatggc tgcaggcggt ggcgcaccaa tggcagacaa taacgaaggc     1500

gccgacggag tgggtagttc ctcgggaaat tggcattgcg attccacatg gctgggcgac     1560

agagtcatca ccaccagcac ccgaacctgg gccctgccca cctacaacaa ccacctctac     1620

aagcaaatct ccaacgggac atcgggagga gccaccaacg acaacaccta cttcggctac     1680

agcaccccct gggggtattt tgactttaac agattccact gccacctttc accacgtgac     1740

tggcagcgac tcatcaacaa caactgggga ttccgaccca agagactcag cttcaagctc     1800

ttcaacatcc aggtcaagga ggtcacgcag aatgaaggca ccaagaccat cgccaataac     1860

ctcaccagca ccatccaggt gtttacggac tcggagtacc agctgccgta cgttctcggc     1920

tctgtccacc agggctgcct gcctccgttc ccggcggacg tgttcatgat tccccagtac     1980

ggctacctaa cactcaacaa cggtagtcag gccgtgggac gctcctcctt ctactgcctg     2040

gaatactttc cttcgcagat gctgagaacc ggcaacaact tccagtttac ttacaccttc     2100

gaggacgtgc ctttccacag cagctacgcc cacagctaga gcttggaccg gctgatgaat     2160

cctctgattg accagtacct gtactacttg tctcggactc aaacaacagg aggcacggca     2220

aatacgcaga ctctgggctt cagccaaggt gggcctaata caatggccaa tcaggcaaag     2280

aactggctgc caggaccctg ttaccgccaa caacgcgtct caacgacaac cgggcaaaac     2340

aacaatagca actttgcctg gactgctggg accaaatacc atctgaatgg aagaaattca     2400

ttggctaatc ctggcatcgc tatggcaaca cacaaagacg acgaggagcg tttttttccc     2460

agtaacggga tcctgatttt tggcaaacaa aatgctgcca gagacaatgc ggattacagc     2520

gatgtcatgc tcaccagcga ggaagaaatc aaaaccacta accctgtggc tacagaggaa     2580

tacggtatcg tggcagataa cttgcagcag caaaacacgg ctcctcaaat tggaactgtc     2640

aacagccagg gggccttacc cggtatggtc tggcagaacc gggacgtgta cctgcagggt     2700

cccatctggg ccaagattcc tcacacggac ggcaacttcc acccgtctcc gctgatgggc     2760

ggctttggcc tgaaacatcc tccgcctcag atcctgatca agaacacgcc tgtacctgcg     2820

gatcctccga ccaccttcaa ccagtcaaag ctgaactctt tcatcacgca atacagcacc     2880

ggacaggtca gcgtggaaat tgaatgggag ctgcagaagg aaaacagcaa gcgctggaac     2940

cccgagatcc agtacacctc caactactac aaatctataa gtgtggactt tgctgttaat     3000

acagaaggcg tgtactctga accccgcccc attggcaccc gttacctcac ccgtaatctg     3060

taattgcctg ttaatcaata aaccggttga ttcgtttcag ttgaactttg gtctctgcga     3120

agggcgaatt c                                                          3131


<210> 4735
<211> 728
<212> PRT
<213> Adeno-associated virus

<400> 4735
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Met Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Gly Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Gly Val Phe Thr Pro 
                645                 650                 655     


Ala Leu Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210> 4736
<211> 644
<212> PRT
<213> Adeno-associated virus


<220>
<221> MOD_RES
<222> (434)..(434)
<223> Any amino acid

<400> 4736
Lys Ala Tyr Asp Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg 
1               5                   10                  15      


Tyr Asn His Ala Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr 
            20                  25                  30          


Ser Phe Gly Gly Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg 
        35                  40                  45              


Val Leu Glu Pro Leu Gly Leu Val Glu Thr Pro Ala Lys Thr Ala Pro 
    50                  55                  60                  


Gly Lys Lys Arg Pro Val Asp Ser Pro Asp Ser Thr Ser Gly Ile Gly 
65                  70                  75                  80  


Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                85                  90                  95      


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            100                 105                 110         


Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly 
        115                 120                 125             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    130                 135                 140                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
145                 150                 155                 160 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                165                 170                 175     


Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn Val 
            180                 185                 190         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        195                 200                 205             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    210                 215                 220                 


Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile Gln 
225                 230                 235                 240 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                245                 250                 255     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            260                 265                 270         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        275                 280                 285             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    290                 295                 300                 


Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
305                 310                 315                 320 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                325                 330                 335     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            340                 345                 350         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg 
        355                 360                 365             


Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln Phe 
    370                 375                 380                 


Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp Leu 
385                 390                 395                 400 


Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp Gln 
                405                 410                 415     


Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His Leu 
            420                 425                 430         


Asn Xaa Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr His 
        435                 440                 445             


Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe 
    450                 455                 460                 


Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu Met 
465                 470                 475                 480 


Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu Glu 
                485                 490                 495     


Tyr Gly Ile Val Ser Ser Asn Leu Gln Ala Ala Ser Thr Ala Ala Gln 
            500                 505                 510         


Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        515                 520                 525             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    530                 535                 540                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
545                 550                 555                 560 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                565                 570                 575     


Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            580                 585                 590         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        595                 600                 605             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    610                 615                 620                 


Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly Val 
625                 630                 635                 640 


Tyr Ser Glu Pro 
                


<210> 4737
<211> 1933
<212> DNA
<213> Adeno-associated virus

<400> 4737
caaggcctac gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc       60

cgacgccgag tttcaggagt gtcttcaaga agatacgtct tttgggggca acctcgggcg      120

agcagtcttc caggccaaaa agcgggttct cgaacctctt ggtctggttg agacgccagc      180

taagacggca cctggaaaga agcgaccggt agactcgcca gactccacct cgggcatcgg      240

caagaaaggc cagcagcccg cgaaaaagag actcaacttt gggcagactg gcgactcaga      300

gtcagtcccc gaccctcaac caatcggaga accaccagca ggcccctctg gtctgggatc      360

tggtacaatg gttgcaggcg gtggcgcacc aatggctgac aataacgagg gcgccgacgg      420

agtgggtaat gcctcaggaa attggcattg cgattccaca tggctgggcg acagagtcat      480

caccaccagc acccgaacct gggccctgcc cacctacaac aaccacctct acaagcaaat      540

ctccagtcag tcagcaggga gcaccaacga taacgtctat ttcggctaca gcaccccctg      600

ggggtatttt gacttcaaca gattccattg ccacttctca ccacgtgact ggcagcgact      660

tatcaacaac aactggggat tccggcccaa gaagctcaac ttcaagctct tcaacatcca      720

ggtcaaggag gtcacgacga atgacggtgt cacaaccatc gctaataacc ttaccagcac      780

ggttcaggtc ttttcggact cggaatatca actgccgtac gtcctcggct ccgcgcacca      840

gggctgcctg cctccgttcc cggcagacgt gttcatgatt ccgcagtacg gatacctgac      900

tctgaacaat ggcagccaat cggtaggccg ttcctccttc tactgcctgg agtactttcc      960

ttctcagatg ctgagaacgg gcaacaactt cacctttagc tacaccttcg aggacgtgcc     1020

tttccacagc agctacgcgc acagccagag tctggaccgg ctgatgaatc ccctcatcga     1080

ccagtacctg tactacttgg ccagaacaca gagcaacgca ggaggtactg ctggcaatcg     1140

ggaactgcag ttttatcagg gcggacctac caccatggcc gaacaagcaa agaactggct     1200

gcccggacct tgcttccggc aacagagagt atccaagacg ctggatcaaa ataacaacag     1260

caactttgcc tggactggtg ccacaaaata ccatttaaat ggaagaaatt cattggttaa     1320

tcccggtgtc gccatggcaa cccacaagga cgacgaggaa cgcttctccc cttcgagcgg     1380

agttctaatt tttggcaaaa ctggagcagc taataaaact acattagaaa acgtgctcat     1440

gacaaatgaa gaagaaattc gtcctaccaa cccggtagct accgaggaat acgggattgt     1500

aagcagcaac ttgcaggcgg ctagcaccgc agcccagaca caagttgtta acaaccaggg     1560

agccttacct ggcatggtct ggcagaaccg ggacgtgtac ctgcaaggtc ccatttgggc     1620

caagattcct cacacggacg gcaactttca cccgtctcct ctaatgggtg gctttggact     1680

gaaacacccg cctccccaga tcctgatcaa aaacacgccg gtacctgcta atcctccaga     1740

agtgtttact cctgccaagt ttgcttcctt catcacgcag tacagcaccg ggcaagtcag     1800

cgttgagatc gagtgggagc tgcagaaaga gaacagcaag cgctggaacc cagagattca     1860

gtacacctcc aactttgaca aacagactgg agtggacttt gctgttgaca gccagggtgt     1920

ttactctgag cct                                                        1933


<210> 4738
<211> 644
<212> PRT
<213> Adeno-associated virus

<400> 4738
Lys Ala Tyr Asp Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg 
1               5                   10                  15      


Tyr Asn His Ala Asp Ala Glu Phe Gln Glu Cys Leu Gln Glu Asp Thr 
            20                  25                  30          


Ser Phe Gly Gly Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg 
        35                  40                  45              


Val Leu Glu Pro Leu Gly Leu Val Glu Thr Pro Ala Lys Thr Ala Pro 
    50                  55                  60                  


Gly Lys Lys Arg Pro Val Asp Ser Pro Asp Ser Thr Ser Gly Ile Gly 
65                  70                  75                  80  


Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                85                  90                  95      


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            100                 105                 110         


Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Val Ala Gly Gly Gly 
        115                 120                 125             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    130                 135                 140                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
145                 150                 155                 160 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                165                 170                 175     


Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn Val 
            180                 185                 190         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        195                 200                 205             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    210                 215                 220                 


Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile Gln 
225                 230                 235                 240 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                245                 250                 255     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            260                 265                 270         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        275                 280                 285             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    290                 295                 300                 


Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
305                 310                 315                 320 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                325                 330                 335     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            340                 345                 350         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg 
        355                 360                 365             


Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln Phe 
    370                 375                 380                 


Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp Leu 
385                 390                 395                 400 


Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp Gln 
                405                 410                 415     


Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His Leu 
            420                 425                 430         


Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr His 
        435                 440                 445             


Lys Asp Asp Glu Glu Arg Phe Ser Pro Ser Ser Gly Val Leu Ile Phe 
    450                 455                 460                 


Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu Met 
465                 470                 475                 480 


Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu Glu 
                485                 490                 495     


Tyr Gly Ile Val Ser Ser Asn Leu Gln Ala Ala Ser Thr Ala Ala Gln 
            500                 505                 510         


Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        515                 520                 525             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    530                 535                 540                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
545                 550                 555                 560 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                565                 570                 575     


Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            580                 585                 590         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        595                 600                 605             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    610                 615                 620                 


Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly Val 
625                 630                 635                 640 


Tyr Ser Glu Pro 
                


<210> 4739
<211> 1933
<212> DNA
<213> Adeno-associated virus

<400> 4739
caaggcctac gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc       60

cgacgccgag tttcaggagc gtcttcaaga agatacgtct tttgggggca acctcgggcg      120

agcagtcttc caggccaaaa agcgggttct cgaacctctt ggtctggttg agacgccagc      180

taagacggca cctggaaaga agcgaccggt agactcgcca gactccacct cgggcatcgg      240

caagaaaggc cagcagcccg cgaaaaagag actcaacttt gggcagactg gcgactcaga      300

gccagtcccc gaccctcaac caatcggaga accaccagca ggcccctctg gtctgggatc      360

tggtacaatg gctgcaggcg gtggcgcacc aatggctgac aataacgagg gcgccgacgg      420

agtgggtaat gcctcaggaa attggcattg cgattccaca cggctgggcg acagagtcat      480

caccaccagc acccgaacct gggccctgcc cacctacaac aaccacctct acaagcaaat      540

ctccagtcag tcagcaggga gcaccaacga taacgtctat ttcggctaca gcaccccctg      600

ggggtatttt gacttcaaca gattccattg ccacttctca ccacgtgact ggcagcgact      660

tatcaacaac aactggggat tccggcccaa gaagctcaac ttcaagctct tcaacatcca      720

ggtcaaggag gtcacgacga atgacggcgt cacaaccatc gctaataacc ttaccagcac      780

ggttcaggtc ttttcggact cggaatatca actgccgtac gtcctcggct ccgcgcacca      840

gggctgcctg cctccgttcc cggcagacgt gttcatgatt ccgcagtacg gatacctgac      900

tctgaacaat ggcagccaat cggtaggccg ttcctccttc tactgcctgg agtactttcc      960

ttctcagatg ctgagaacgg gcaacaactt cacctttagc tacaccttcg aggacgtgcc     1020

tttccacagc agctacgcgc acagccagag tctgggccgg ctgatgaatc ccctcatcga     1080

ccagtacctg tactacttgg ccagaacaca gagcaacgca ggaggtactg ctggcaatcg     1140

ggaactgcag ttttatcagg gcggacctac caccatggcc gaacaagcaa agaactggct     1200

gcccggacct tgcttccggc aacagagagt atccaagacg ctggatcaaa ataacaacag     1260

caactttgcc tggactggtg ccacaaaata ccatttaaat ggaagaaatt cattggttaa     1320

tcccggtgtc gccatggcaa cccacaagga cgacgaggaa cgcttcttcc cttcgagcgg     1380

agttctaatt tttggcaaaa ctggagcagc taataaaact acattagaaa acgtgctcat     1440

gacaaatgaa gaagaaattc gtcctaccaa cccggtagct accgaggaat acgggattgt     1500

aagcagcaac ttgcaggcgg ctagcaccgc agcccagaca caagttgtta acaaccaggg     1560

agccttacct ggcatggtct ggcagaaccg ggacgtgtac ctgcaaggtc ccatttgggc     1620

caagattcct cacacggacg gcaactttca cccgtctcct ctaatgggtg gctttggact     1680

gaaacacccg cctccccaga tcctgatcaa aaacacaccg gtacctgcta atcctccaga     1740

agtgtttact cctgccaagt ttgcttcctt catcacgcag tacagcaccg ggcaagtcag     1800

cgttgagatc gaatgggagc tgcagaaaga gaacagcaag cgctggaacc cagagattca     1860

gtacacctcc aactttgaca aacagactgg agtggacttt gctgttgaca gccagggtgt     1920

ttactctgag cct                                                        1933


<210> 4740
<211> 644
<212> PRT
<213> Adeno-associated virus

<400> 4740
Lys Ala Tyr Asp Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg 
1               5                   10                  15      


Tyr Asn His Ala Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr 
            20                  25                  30          


Ser Phe Gly Gly Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg 
        35                  40                  45              


Val Leu Glu Pro Leu Gly Leu Val Glu Thr Pro Ala Lys Thr Ala Pro 
    50                  55                  60                  


Gly Lys Lys Arg Pro Val Asp Ser Pro Asp Ser Thr Ser Gly Ile Gly 
65                  70                  75                  80  


Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                85                  90                  95      


Gly Asp Ser Glu Pro Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            100                 105                 110         


Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly 
        115                 120                 125             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    130                 135                 140                 


Ser Gly Asn Trp His Cys Asp Ser Thr Arg Leu Gly Asp Arg Val Ile 
145                 150                 155                 160 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                165                 170                 175     


Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn Val 
            180                 185                 190         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        195                 200                 205             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    210                 215                 220                 


Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile Gln 
225                 230                 235                 240 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                245                 250                 255     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            260                 265                 270         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        275                 280                 285             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    290                 295                 300                 


Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
305                 310                 315                 320 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                325                 330                 335     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Gly 
            340                 345                 350         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg 
        355                 360                 365             


Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln Phe 
    370                 375                 380                 


Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp Leu 
385                 390                 395                 400 


Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp Gln 
                405                 410                 415     


Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His Leu 
            420                 425                 430         


Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr His 
        435                 440                 445             


Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe 
    450                 455                 460                 


Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu Met 
465                 470                 475                 480 


Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu Glu 
                485                 490                 495     


Tyr Gly Ile Val Ser Ser Asn Leu Gln Ala Ala Ser Thr Ala Ala Gln 
            500                 505                 510         


Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        515                 520                 525             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    530                 535                 540                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
545                 550                 555                 560 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                565                 570                 575     


Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            580                 585                 590         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        595                 600                 605             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    610                 615                 620                 


Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly Val 
625                 630                 635                 640 


Tyr Ser Glu Pro 
                


<210> 4741
<211> 1933
<212> DNA
<213> Adeno-associated virus

<400> 4741
caaggcctac gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc       60

cgacgccgag tttcaggagc gtcttcaaga agatacgtct tttgggggca acctcgggcg      120

agcagtcttc caggccaaaa agcgggttct cgaacctctt ggtctggttg agacgccagc      180

taagacggca cctggaaaga agcgaccggt agactcgcca gactccacct cgggcatcgg      240

caagaaaggc cagcagcccg cgaaaaagag actcaacttt gggcagactg gcgactcaga      300

gccagtcccc gaccctcaac caatcggaga accaccagca ggcccctctg gtctgggatc      360

tggtacaatg gctgcaggcg gtggcgcacc aatggctgac aataacgagg gcgccgacgg      420

agtgggtaat gcctcaggaa attggcattg cgattccaca cggctgggcg acagagtcat      480

caccaccagc acccgaacct gggccctgcc cacctacaac aaccacctct acaagcaaat      540

ctccagtcag tcagcaggga gcaccaacga taacgtctat ttcggctaca gcaccccctg      600

ggggtatttt gacttcaaca gattccattg ccacttctca ccacgtgact ggcagcgact      660

tatcaacaac aactggggat tccggcccaa gaagctcaac ttcaagctct tcaacatcca      720

ggtcaaggag gtcacgacga atgacggcgt cacaaccatc gctaataacc ttaccagcac      780

ggttcaggtc ttttcggact cggaatatca actgccgtac gtcctcggct ccgcgcacca      840

gggctgcctg cctccgttcc cggcagacgt gttcatgatt ccgcagtacg gatacctgac      900

tctgaacaat ggcagccaat cggtaggccg ttcctccttc tactgcctgg agtactttcc      960

ttctcagatg ctgagaacgg gcaacaactt cacctttagc tacaccttcg aggacgtgcc     1020

tttccacagc agctacgcgc acagccagag tctgggccgg ctgatgaatc ccctcatcga     1080

ccagtacctg tactacttgg ccagaacaca gagcaacgca ggaggtactg ctggcaatcg     1140

ggaactgcag ttttatcagg gcggacctac caccatggcc gaacaagcaa agaactggct     1200

gcccggacct tgcttccggc aacagagagt atccaagacg ctggatcaaa ataacaacag     1260

caactttgcc tggactggtg ccacaaaata ccatttaaat ggaagaaatt cattggttaa     1320

tcccggtgtc gccatggcaa cccacaagga cgacgaggaa cgcttcttcc cttcgagcgg     1380

agttctaatt tttggcaaaa ctggagcagc taataaaact acattagaaa acgtgctcat     1440

gacaaatgaa gaagaaattc gtcctaccaa cccggtagct accgaggaat acgggattgt     1500

aagcagcaac ttgcaggcgg ctagcaccgc agcccagaca caagttgtta acaaccaggg     1560

agccttacct ggcatggtct ggcagaaccg ggacgtgtac ctgcaaggtc ccatttgggc     1620

caagattcct cacacggacg gcaactttca cccgtctcct ctaatgggtg gctttggact     1680

gaaacacccg cctccccaga tcctgatcaa aaacacaccg gtacctgcta atcctccaga     1740

agtgtttact cctgccaagt ttgcttcctt catcacgcag tacagcaccg ggcaagtcag     1800

cgttgagatc gaatgggagc tgcagaaaga gaacagcaag cgctggaacc cagagattca     1860

gtacacctcc aactttgaca aacagactgg agtggacttt gctgttgaca gccagggtgt     1920

ttactctgag cct                                                        1933


<210> 4742
<211> 644
<212> PRT
<213> Adeno-associated virus

<400> 4742
Lys Ala Tyr Asp Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg 
1               5                   10                  15      


Tyr Asn His Ala Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr 
            20                  25                  30          


Ser Phe Gly Gly Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg 
        35                  40                  45              


Val Leu Glu Pro Leu Gly Leu Val Glu Thr Pro Ala Lys Thr Ala Pro 
    50                  55                  60                  


Gly Lys Lys Arg Pro Val Asp Ser Pro Asp Ser Thr Ser Gly Ile Gly 
65                  70                  75                  80  


Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                85                  90                  95      


Gly Asp Ser Glu Pro Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            100                 105                 110         


Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly 
        115                 120                 125             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    130                 135                 140                 


Ser Gly Asn Trp His Cys Asp Ser Thr Arg Leu Gly Asp Arg Val Ile 
145                 150                 155                 160 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                165                 170                 175     


Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn Val 
            180                 185                 190         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        195                 200                 205             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    210                 215                 220                 


Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile Gln 
225                 230                 235                 240 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                245                 250                 255     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            260                 265                 270         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        275                 280                 285             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    290                 295                 300                 


Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
305                 310                 315                 320 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                325                 330                 335     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Gly 
            340                 345                 350         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg 
        355                 360                 365             


Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln Phe 
    370                 375                 380                 


Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp Leu 
385                 390                 395                 400 


Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp Gln 
                405                 410                 415     


Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His Leu 
            420                 425                 430         


Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr His 
        435                 440                 445             


Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe 
    450                 455                 460                 


Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu Met 
465                 470                 475                 480 


Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu Glu 
                485                 490                 495     


Tyr Gly Ile Val Ser Ser Asn Leu Gln Ala Ala Ser Thr Ala Ala Gln 
            500                 505                 510         


Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        515                 520                 525             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    530                 535                 540                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
545                 550                 555                 560 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                565                 570                 575     


Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            580                 585                 590         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        595                 600                 605             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    610                 615                 620                 


Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly Val 
625                 630                 635                 640 


Tyr Ser Glu Pro 
                


<210> 4743
<211> 1933
<212> DNA
<213> Adeno-associated virus

<400> 4743
caaggcctac gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc       60

cgacgccgag tttcaggagc gtcttcaaga agatacgtct tttgggggca acctcgggcg      120

agcagtcttc caggccaaaa agcgggttct cgaacctctt ggtctggttg agacgccagc      180

taagacggca cctggaaaga agcgaccggt agactcgcca gactccacct cgggcatcgg      240

caagaaaggc cagcagcccg cgaaaaagag actcaacttt gggcagactg gcgactcaga      300

gtcagtcccc gaccctcaac caatcggaga accaccagca ggcccctctg gtctgggatc      360

tggtacaatg gctgcaggcg gtggcgcacc aatggctgac aatagcgagg gcgccgacgg      420

agtgggtaat gcctcaggaa attggcattg cgattccaca tggctgggcg acagagtcat      480

caccaccagc acccgaacct gggccctgcc cacctacaac aaccacctct acaagcaaat      540

ctccagtcag tcagcaggga gcaccaacga taacgtctat ttcggctaca gcaccccctg      600

ggggtatttt gacttcaaca gattccattg ccacttctca ccacgtgact ggcagcgact      660

tatcaacaac aactggggat tccggcccaa gaagctcaac ttcaagctct tcaacatcca      720

ggtcaaggag gtcacgacga atgacggtgt cacaaccatc gctaataacc ttaccagcac      780

ggttcaggtc ttttcggact cggaatatca actgccgtac gtcctcggct ccgcgcacca      840

gggctgcctg cctccgttcc cggcagacgt gttcatgatt ccgcagtacg gatacctgac      900

tctgaacaat ggcagccaat cggtaggccg ttcctccttc tactgcctgg agtactttcc      960

ttctcagatg ctgagaacgg gcaacaactt cacctttagc tacaccttcg aggacgtgcc     1020

tttccacagc agctacgcgc acagccagag tctggaccgg ctgatgaatc ccctcatcga     1080

ccagtacctg tactacttgg ccagaacaca gagcaacgca ggaggtactg ctggcaatcg     1140

ggaactgcag ttttatcagg gcggacctac caccatggcc gaacaagcaa agaactggct     1200

gcccggacct tgcttccggc aacagagagt atccaagacg ctggatcaaa ataacaacag     1260

caactttgcc tggactggtg ccacaaaata ccatttaaat ggaagaaatt cattggttaa     1320

tcccggtgtc gccatggcaa cccacaagga cgacgaggaa cgcttcttcc cttcgagcgg     1380

agttctaatt tttggcaaaa ctggagcagc taataaaact acattagaaa acgtgctcat     1440

gacaaatgaa gaagaaattc gtcctaccaa cccggtagct accgaggaat acgggattgt     1500

aagcagcaac ttgcaggcgg ctagcaccgc agcccagaca caagttgtta acaaccaggg     1560

agccttacct ggcatggtct ggcagaaccg ggacgtgtac ctgcaaggtc ccatttgggc     1620

caagattcct cacacggacg gcaactttca cccgtctcct ctaatgggtg gctttggact     1680

gaaacacccg cctccccaga tcctgatcaa aaacacaccg gtacctgcta atcctccaga     1740

agtgtttact cctgccaagc ttgcttcctt catcacgcag tacagcaccg ggcaagtcag     1800

cgttgagatc gagtgggagc tgcagaaaga gaacagcaag cgctggaacc cagagattca     1860

gtacacctcc aactttgaca aacagactgg agtggacttt gctgttgaca gccagggtgt     1920

ttactctgag cct                                                        1933


<210> 4744
<211> 644
<212> PRT
<213> Adeno-associated virus

<400> 4744
Lys Ala Tyr Asp Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg 
1               5                   10                  15      


Tyr Asn His Ala Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr 
            20                  25                  30          


Ser Phe Gly Gly Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg 
        35                  40                  45              


Val Leu Glu Pro Leu Gly Leu Val Glu Thr Pro Ala Lys Thr Ala Pro 
    50                  55                  60                  


Gly Lys Lys Arg Pro Val Asp Ser Pro Asp Ser Thr Ser Gly Ile Gly 
65                  70                  75                  80  


Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                85                  90                  95      


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            100                 105                 110         


Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly 
        115                 120                 125             


Ala Pro Met Ala Asp Asn Ser Glu Gly Ala Asp Gly Val Gly Asn Ala 
    130                 135                 140                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
145                 150                 155                 160 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                165                 170                 175     


Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn Val 
            180                 185                 190         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        195                 200                 205             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    210                 215                 220                 


Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile Gln 
225                 230                 235                 240 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                245                 250                 255     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            260                 265                 270         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        275                 280                 285             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    290                 295                 300                 


Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
305                 310                 315                 320 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                325                 330                 335     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            340                 345                 350         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg 
        355                 360                 365             


Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln Phe 
    370                 375                 380                 


Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp Leu 
385                 390                 395                 400 


Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp Gln 
                405                 410                 415     


Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His Leu 
            420                 425                 430         


Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr His 
        435                 440                 445             


Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe 
    450                 455                 460                 


Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu Met 
465                 470                 475                 480 


Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu Glu 
                485                 490                 495     


Tyr Gly Ile Val Ser Ser Asn Leu Gln Ala Ala Ser Thr Ala Ala Gln 
            500                 505                 510         


Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        515                 520                 525             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    530                 535                 540                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
545                 550                 555                 560 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                565                 570                 575     


Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Leu Ala Ser Phe Ile Thr 
            580                 585                 590         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        595                 600                 605             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    610                 615                 620                 


Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly Val 
625                 630                 635                 640 


Tyr Ser Glu Pro 
                


<210> 4745
<211> 1933
<212> DNA
<213> Adeno-associated virus

<400> 4745
caaggcctac gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc       60

cgacgccgag tttcaggagc gtcttcaaga agatacgtct tttgggggca acctcgggcg      120

agcagtcttc caggccaaaa agcgggttct cgaacctctt ggtctggttg agacgccagc      180

taagacggca cctggaaaga agcgaccggt agactcgcca gactccacct cgggcatcgg      240

caagaaaggc cagcagcccg cgaaaaagag actcaacttt gggcagactg gcgactcaga      300

gtcagtcccc gaccctcaac caatcggaga accaccagca ggcccctctg gtctgggatc      360

tggtacaatg gctgcaggcg gtggcgcacc aatggctgac aataacgagg gcgccgacgg      420

agtgggtaat gcctcaggaa attggcattg cgattccaca tggctgggcg acagagtcat      480

caccaccagc acccgaacct gggccctgcc cacctacaac aaccacctct acaagcaaat      540

ctccagtcag tcagcaggga gcaccaacga taacgtctat ttcggctaca gcaccccctg      600

ggggtatttt gacttcaaca gattccattg ccacttctca ccacgtgact ggcagcgact      660

tatcaacaac aactggggat tccggcccaa gaagctcaac ttcaagctct tcaacatcca      720

ggtcaaggag gtcacgacga atgacggcgt cacaaccatc gctaataacc ttaccagcac      780

ggttcaggtc ttttcggacc cggaatatca actgccgtac gtcctcggct ccgcgcacca      840

gggctgcctg cctccgttcc cggcagacgt gttcatgatt ccgcagtacg gatacctgac      900

tctgaacaat ggcagccaat cggtaggccg ttcctccttc tactgcctgg agtactttcc      960

ttctcagatg ctgagaacgg gcaacaactt cacctttagc tacaccttcg aggacgtgcc     1020

tttccacagc agctacgcgc acagccagag tctggaccgg ctgatgaatc ccctcatcga     1080

ccagtacctg tactacttgg ccagaacaca gagcaacgca ggaggtactg ctggcaatcg     1140

ggaactgcag ttttatcagg gcggacctac caccatggcc gaacaagcaa agaactggct     1200

gcccggacct tgcttccggc aacagagagt atccaagacg ctggatcaaa ataacaacag     1260

caactttgcc tggactggtg ccacaaaata ccatttaaat ggaagaaatt cattggttaa     1320

tcccggtgtc gccatggcaa cccacaagga cgacgaggaa cgcttcttcc cttcgagcgg     1380

agttctaatt tttggcaaaa ctggagcagc taataaaact acattagaaa acgtgctcat     1440

gacaaatgaa gaagaaattc gtcctaccaa cccggtagct accgaggaat acgggattgt     1500

aagcagcaac ttgcaggcgg ctagcaccgc agcccagaca caagttgtta acaaccaggg     1560

agccttacct ggcatggtct ggcagaaccg ggacgtgtac ctgcaaggtc ccatttgggc     1620

caagattcct cacacggacg gcaactttca cccgtctcct ctaatgggtg gctttggact     1680

gaaacacccg cctccccaga tcctgatcaa aaacacaccg gtacctgcta atcctccaga     1740

agtgtttact cctgccaaga ttgcttcctt catcacgcag tacagcaccg ggcaagtcag     1800

cgttgagatc gagtgggagc tgcagaaaga gaacagcaag cgctggaacc cagagattca     1860

gtacacctcc aactttgaca aacagactgg agtggacttt gctgttgaca gccagggtgt     1920

ttactctgag cct                                                        1933


<210> 4746
<211> 644
<212> PRT
<213> Adeno-associated virus

<400> 4746
Lys Ala Tyr Asp Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg 
1               5                   10                  15      


Tyr Asn His Ala Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr 
            20                  25                  30          


Ser Phe Gly Gly Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg 
        35                  40                  45              


Val Leu Glu Pro Leu Gly Leu Val Glu Thr Pro Ala Lys Thr Ala Pro 
    50                  55                  60                  


Gly Lys Lys Arg Pro Val Asp Ser Pro Asp Ser Thr Ser Gly Ile Gly 
65                  70                  75                  80  


Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                85                  90                  95      


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            100                 105                 110         


Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly 
        115                 120                 125             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    130                 135                 140                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
145                 150                 155                 160 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                165                 170                 175     


Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn Val 
            180                 185                 190         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        195                 200                 205             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    210                 215                 220                 


Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile Gln 
225                 230                 235                 240 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                245                 250                 255     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Pro Glu Tyr Gln Leu Pro 
            260                 265                 270         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        275                 280                 285             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    290                 295                 300                 


Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
305                 310                 315                 320 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                325                 330                 335     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            340                 345                 350         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg 
        355                 360                 365             


Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln Phe 
    370                 375                 380                 


Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp Leu 
385                 390                 395                 400 


Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp Gln 
                405                 410                 415     


Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His Leu 
            420                 425                 430         


Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr His 
        435                 440                 445             


Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe 
    450                 455                 460                 


Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu Met 
465                 470                 475                 480 


Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu Glu 
                485                 490                 495     


Tyr Gly Ile Val Ser Ser Asn Leu Gln Ala Ala Ser Thr Ala Ala Gln 
            500                 505                 510         


Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        515                 520                 525             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    530                 535                 540                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
545                 550                 555                 560 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                565                 570                 575     


Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Ile Ala Ser Phe Ile Thr 
            580                 585                 590         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        595                 600                 605             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    610                 615                 620                 


Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly Val 
625                 630                 635                 640 


Tyr Ser Glu Pro 
                


<210> 4747
<211> 728
<212> PRT
<213> Adeno-associated virus

<400> 4747
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Arg Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Val Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Ser Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Val His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Cys Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210> 4748
<211> 728
<212> PRT
<213> Adeno-associated virus

<400> 4748
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Ser Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Cys Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Val 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Leu 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Arg Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Glu Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210> 4749
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4749
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Thr Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala Arg Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Gly Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Asp 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4750
<211> 3121
<212> DNA
<213> Adeno-associated virus

<400> 4750
gaattcgccc ttcgcagaga ccaaagttca actgaaacga atcaaccggt ttattgatta       60

acaagcaatt acagattacg ggtgaggtaa cgggtgccga tggggcgagg ctcagaataa      120

gtgccatctg tgttaacagc aaagtccaca tttgtagatt tgtagtagtt ggaagtgtat      180

tgaatctctg ggttccagcg tttgctgttt tctttctgca gctcccattc aatttccacg      240

ctgacctgtc cggtgctgta ctgcgtgatg aacgacgcca gcttagcttg actgaaggta      300

gttggaggat ccgcgggaac aggtgtattc ttaatcagga tctgaggagg cgggtgtttc      360

agtccaaagc cccccatcag cggcgaggga tgaaagtttc cgtccgtgtg aggaatcttg      420

gcccagatag gaccctgcag gtacacgtcc cggttctgcc agaccatgcc aggtaaggct      480

ccttgactgt tgacggcccc tacaatagga gcggcgtttt gctgttgcag gttatcggcc      540

accacgccgt actgttctgt ggccactggg ttggtggttt taatttcttc ctcactggtt      600

agcataacgc tgctatagtc cacgttgcct tttccagctc cctgtttccc aaacattaag      660

actccgctgg acggaaaaaa tcgctcttcg tcgtccttgt gggttgccat agcgacaccg      720

ggatttacca gagagtctct gccattcaga tgatacttgg tggcaccggt ccaggcaaag      780

ttgctgttgt tattttgcga cagtgtcgtg gagacgcgtt gctgccggta gcagggcccg      840

ggtagccagt ttttggcctg agccgacatg ttattaggcc cggcctgaga aaatagcaac      900

tgctgagttc ctgcggtacc tcccgtggac tgagtccgag acaggtagta caggtactgg      960

tcgatgaggg ggttcatcag ccggtccagg ctttggctgt gcgcgtagct gctgtgaaaa     1020

ggcacgtcct caaactggta gctgaactca aagttgttgc ccgttctcag catttgagaa     1080

ggaaagtact ccaggcagta gaaggaggaa cggcccacgg cctgactgcc attgttcaga     1140

gtcaggtacc cgtactgagg aatcatgaag acgtccgccg ggaacggagg caggcagccc     1200

tggcgcgcag agccgaggac gtacgggagc tggtattccg agtccgtaaa gacctgaatc     1260

gtgctggtaa ggttattggc gatggtcttg gtgccttcat tctgcgtgac ctccttgacc     1320

tggatgttga agagcttgaa gttgagtctc ttgggccgga atccccagtt gttgttgatg     1380

agtcgctgcc agtcacgtgg tgagaagtgg cagtggaatc tgttaaagtc aaaatacccc     1440

cagggggtgc tgtagccgaa gtaggtgttg tcgttggtgc ttcctcccga agtcccgttg     1500

gagatttgct tgtagaggtg gttgttgtag gtggggaggg cccaggttcg ggtgctggtg     1560

gtgatgactc tgtcgcccag ccatgtggaa tcgcaatgcc aatttcctga ggaactaccc     1620

actccgtcgg cgccttcgtt attgtctgcc attggagcgc caccgcctgc agccattgta     1680

ccagatccca gaccagaggg gcctgcgggg ggttctccga ttggttgagg gtcgggcact     1740

gactctgagt cgccagtctg cccaaagttg agtctctttt tcgcgggctg ctggcctttc     1800

ttgccgatgc ccgtagtgga gtctggagaa cgctggggtg atggctctac cggtctcttc     1860

tttccaggag ccgtcttagc gccttcctca accagaccga gaggttcgag aacccgcttc     1920

ttggcctgga agactgctcg tccgaggttg cccccaaaag acgtatcttc ttgcagacgc     1980

tcctgaaact cggcgtcggc gtggttatac cgcaggtacg gattgtcacc cgctttgagc     2040

tgctggtcgt aggccttgtc gtgctcgagg gccgctgcgt ccgccgcgtt gacgggctcc     2100

cccttgtcga gtccgttgaa gggtccgagg tacttgtagc caggaagcac cagaccccgg     2160

ccgtcgtcct gcttttgctg gttggctttg ggcttcgggg ctccaggttt cagcgcccac     2220

cactcgcgaa tgccctcaga gaggttgtcc tcgagccaat ctggaagata accatcggca     2280

gccatacctg atctaaatca tttattgttc aaagatgcag tcatccaaat ccacattgac     2340

cagatcgcag gcagtgcaag cgtctggcac ctttcccatg atatgatgaa tgtagcacag     2400

tttctgatac gcctttttga cgacagaaac gggttgagat tctgacacgg gaaagcactc     2460

taaacagtct ttctgtccgt gagtgaagca gatatttgaa ttctgattca ttctctcgca     2520

ttgtctgcag ggaaacagca tcagattcat gcccacgtga cgagaacatt tgttttggta     2580

cctgtccgcg tagttgatcg aagcttccgc gtctgacgtc gatggctgcg caactgactc     2640

gcgcacccgt ttgggctcac ttatatctgc gtcactgggg gcgggtcttt tcttggctcc     2700

accctttttg acgtagaatt catgctccac ctcaaccacg tgatcctttg cccaccggaa     2760

aaagtctttg acttcctgct tggtgacctt cccaaagtca tgatccagac ggcgggtgag     2820

ttcaaatttg aacatccggt cttgcaacgg ctgctggtgt tcgaaggtcg ttgagttccc     2880

gtcaatcacg gcgcacatgt tggtgttgga ggtgacgatc acgggagtcg ggtctatctg     2940

ggccgaggac ttgcatttct ggtccacgcg caccttgctt cctccgagaa tggctttggc     3000

cgactccacg accttggcgg tcatcttccc ctcctcccac cagatcacca tcttgtcgac     3060

acagtcgttg aagggaaagt tctcattggt ccagttgacg cagccgtaga agggcgaatt     3120

c                                                                     3121


<210> 4751
<211> 3121
<212> DNA
<213> Adeno-associated virus

<400> 4751
gaattcgccc ttctacggct gcgtcaactg gaccaatgag aactttccct tcaacgactg       60

tgtcgacaag atggtgatct ggtgggagga ggggaagatg accgccaagg tcgtggagtc      120

ggccaaagcc attctcggag gaagcaaggt gcgcgtggac cagaaatgca agtcctcggc      180

ccagatagac ccgactcccg tgatcgtcac ctccaacacc aacatgtgcg ccgtgattga      240

cgggaactca acgaccttcg aacaccagca gccgttgcaa gaccggatgt tcaaatttga      300

actcacccgc cgtctggatc atgactttgg gaaggtcacc aagcaggaag tcaaagactt      360

tttccggtgg gcaaaggatc acgtggttga ggtggagcac gaattctacg tcaaaaaggg      420

tggagccaag aaaagacccg cccccagtga cgcagatata agtgagccca aacgggtgcg      480

cgagtcagtt gcgcagccat cgacgtcaga cgcggaagct tcgatcaact acgcagacag      540

gtaccaaaac aaatgttctc gtcacgcggg catgaatctg atgctgtttc cctgcagaca      600

atgcgagaga atgaatcaga attcaaatat ctgcttcact cacggacaga aagactgttt      660

agagtgcttt cccgtgtcag aatctcaacc cgtttctgtc gtcaaaaagg cgtatcagaa      720

actgtgctac attcatcata tcatgggaaa ggtgccagac gcttgcactg cctgcgatct      780

ggtcgatgtg gatttggatg actgcatctt tgaacaataa atgatttaaa tcaggtatgg      840

ctgccgatgg ttatcttcca gattggctcg aggacaacct ctctgagggc attcgcgagt      900

ggtgggcgct gaaacctgga gccccgaagc ccaaagccaa ccagcaaaag caggacggcg      960

gccggggtct ggtgcttcct ggctacaagt acctcggacc cttcaacgga ctcgacaagg     1020

gggagcccgt caacgcggcg gacgcagcgg ccctcgagca cgacaaggcc tacgaccagc     1080

agctcaaagc gggtgacaat ccgtacctgc ggtataacca cgccgacgcc gagtttcagg     1140

agcgtctgca agaagatacg tcttttgggg gcaacctcgg gcgagcagtc ttccaggcca     1200

agaagcgggt tctcgaacct ctcggtctgg ttgaggaagg cgctaagacg gctcctggaa     1260

agaagagacc ggtagagcca tcaccccagc gttctccaga ctcctctacg ggcatcggca     1320

agaaaggcca gcagcccgcg aaaaagagac tcaactttgg gcagactggc gactcagagt     1380

cagtgcccga ccctcaacca atcggagaac cccccgcagg cccctctggt ctgggatctg     1440

gtacaatggc tgcaggcggt ggcgctccaa tggcagacaa taacgaaggc gccgacggag     1500

tgggtagttc ctcaggaaat tggcattgcg attccacatg gctgggcgac tgagtcatca     1560

ccaccagcac ccgaacctgg gccctcccca cctacaacaa ccacctctac aagcaaatct     1620

ccaacgggac ttcgggagga agcaccaacg acaacaccta cttcggctac agcaccccct     1680

gggggtattt tgactttaac agattccact gccacttctc accacgtgac tggcagcgac     1740

tcatcaacaa caactgggga ttccggccca agagactcaa cttcaagctc ttcaacatcc     1800

aggtcaagga ggtcacgcag aatgaaggca ccaagaccat cgccaataac cttaccagca     1860

cgattcaggt ctttacggac tcggaatacc agctcccgta cgtcctcggc tctgcgcacc     1920

agggctgcct gcctccgttc ccggcggacg tcttcatgat tcctcagtac gggtacctga     1980

ctctgaacaa tggcagtcag gccgtgggcc gttcctcctt ctactgcctg gagtactttc     2040

cttctcaaat gctgagaacg ggcaacaact ttgagttcag ctaccagttt gaggacgtgc     2100

cttttcacag cagctacgcg cacagccaaa gcctggaccg gctgatgaac cccctcatcg     2160

accagtacct gtactacctg tctcggactc agtccacggg aggtaccgca ggaactcagc     2220

agttgctatt ttctcaggcc gggcctaata acatgtcggc tcaggccaaa aactggctac     2280

ccgggccctg ctaccggcag taacgcgtct ccacgacact gtcgcaaaat aacaacagca     2340

actttgtctg gaccggtgcc accaagtatc atctgaatgg cagagactct ctggtagatc     2400

ccggtgtcgc tatggcaacc cacaaggacg acgaagagcg attttttccg tccagcggag     2460

tcataatgtt tgggaaacag ggagctggaa aagacaacgt ggactatagc agcgtcatgc     2520

taaccagtga ggaagaaatt aaaaccacca acccagtggc cacagaacag tacggcgtgg     2580

tggccgataa cctgcaacag caaaacgccg ctcctattgt aggggccgtc aacagtcaag     2640

gagccttacc tggcatggtc tggcagaacc gggacgtgta cctgcagggt cctacctggg     2700

ccaagattcc tcacacggac ggaaactttc atccctcgcc gctgatggga ggctttggac     2760

tgaaacaccc gcctcctcag atcctgatta agaatacacc tgttcccgcg gatcctccaa     2820

ctaccttcag tcaagctaag ctggcgtcgt tcatcacgca gtacagcacc ggacaggtca     2880

gcgtggaaat tgaatgggag ctgcaggaag aaaacagcaa acgctggaac ccagagattc     2940

aatacacttc caactactac aaatctacaa atgtggactt tgctgttaac acagatggca     3000

cttattctga gcctcgcccc atcggcaccc gttacctcac ccgtaatctg taattgcttg     3060

ttaatcaata aaccggttga ttcgtttcag ttgaactttg gtctctgcga agggcgaatt     3120

c                                                                     3121


<210> 4752
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4752
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Gly Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Ser Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asp Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Asp 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4753
<211> 3121
<212> DNA
<213> Adeno-associated virus

<400> 4753
gaattcgccc ttcgcgagac caaagttcaa ctgaaacgaa tcaaccggtt tattgattaa       60

caagcaatta cagattacgg gtgaggtaac gggtgccgat ggggcgaggc tcagaataag      120

tgccatctgt gttaacagca aagtccacat ttgtagattt gtagtagttg gaagtgtatt      180

gaatctctgg gttccagcgt ttgctgtttt ctttctgcag ctcccattca atttccacgc      240

tgacctgtcc ggtgctgtac tgcgtgatga acgacgccag cttagcttga ctgaaggtag      300

ttggaggatc cgcgggaaca ggtgtattct taatcaggat ctgaggaggc gggtgtttca      360

gtccaaagcc tcccatcagc ggcgagggat gaaagtttcc gtccgtgtga ggaatcttgg      420

cccagatagg accctgcagg tacacgtccc ggttctgcca gaccatgcca ggtaaggctc      480

cttgactgtt gacggcccct acaataggag cggcgttttg ctgttgcagg ttatcggcca      540

ccacgccgta ctgttctgtg gccactgggt tggtggtttt aatttcttcc tcactggtta      600

gcataacgct gctatagtcc acgttgtctt ttccagctcc ctgtttccca aacattaaga      660

ctccgctgga cggaaaaaat cgctcttcgt cgtccttgtg ggttgccata gcgacaccgg      720

gatttaccag agagtctctg ccattcagat gatacttggt ggcaccggtc caggcaaagt      780

tgctgttgtc attttgcgac agtgtcgtgg agacgcgttg ctgccggtag cagggcccgg      840

gtagccagtt tttggcctga gccgacatgt tattaggccc ggcctgagaa aatagcaact      900

gctgagttcc tgcggtacct cccgtggact gagtccgaga caggtagtac aggtactggt      960

cgatgagggg gttcatcagc cggtccaggc tttggctgtg cgcgtagctg ctgtgaaaag     1020

gcacgtcctc aaactggtag ctgaactcaa agttgttgcc cgttctcagc atttgagaag     1080

gaaagtactc caggcagtag aaggaggaac ggcccacggc ctgactgcca ttgttcagag     1140

tcaggtaccc gtactgagga atcatgaaga cgtccgccgg gaacggaggc aggcagccct     1200

ggtgcgcaga gccgaggacg tacgggagct ggtattccga gtccgtaaag acctgaatcg     1260

tgctggtaag gttattggcg atggtcttgg tgccttcatt ctgcgtgacc tccttgacct     1320

ggatgttgaa gagcttgaag ttgaggctct tgggccggaa tccccagttg ttgttgatga     1380

gtcgctgcca gtcacgtggt gagaagtggc agtggaatct gttaaagtca aaataccccc     1440

agggggtgct gtagccgaag taggtgttgt cgttggtgct tcctcccgaa gtcccgttgg     1500

agatttgctt gtagaggtgg ttgttgtagg tggggagggc ccaggttcgg gtgctggtgg     1560

tgatgactcc gtcgcccagc catgtggaat cgcaatgcca atttcctgag gaactaccca     1620

ctccgtcggc gccttcgtta ttgtctgcca ttggagcgcc accgcctgca gccattgtac     1680

cagatcccag accagagggg cctgcggggg gttctccgat tggttgaggg tcgggcactg     1740

actctgagtc gccagtctgc ccaaagttga gtctcttttt cgcgggctgc tggcctttct     1800

tgccgatgcc cgtagaggag tctggagaac gctggggtga tggctctacc ggtctcttct     1860

ttccaggagc cgtcttagcg ccttcctcaa ccagaccgag aggttcgaga acccgcttct     1920

tggcctggaa gactgctcgc ccgaggttgc ccccaaaaga cgtatcttct tgcagacgct     1980

cctgaaactc ggcgtcggcg tggttatacc gcaggtacgg attgtcaccc gctttgagct     2040

gctggtcgta ggccttgtcg tgctcgaggg ccgctgcgtc cgccgcgttg acgggctccc     2100

ccttgtcgag tccgttgaag ggtccgaggt acttgtagcc aggaagcacc agaccccggc     2160

cgtcgtcctg cttttgctgg ttggctttgg gcttcggggc tccaggtttc agcgcccacc     2220

actcgcgaat gccctcagag aggttgtcct cgagccaatc tggaagataa ccatcggcag     2280

ccatacctga tttaaatcat ttattgttca aagatgcagt catccaaatc cacattgacc     2340

agatcgcagg cagtgcaagc gtctggcacc tttcccatga tatgatgaat gtagcacagt     2400

ttctgatacg cctttttgac gacagaaacg ggttgagatt ctgacacggg aaagcactct     2460

aaacagtctt tctgtccgtg agtgaagcag atatttgaat tctgattcat tctctcgcat     2520

tgtctgcagg gaaacagcat cagattcatg cccacgtgac gagaacattt gttttggtac     2580

ctgtctgcgt agttgatcga agcttccgcg tctgacgtcg atggctgcgc aactgactcg     2640

cgcacccgtt tgggctcact tatatctgcg tcactggggg cgggtctttt cttggctcca     2700

ccctttttga cgtagaattc atgctccacc tcaaccacgt gatcctttgc ccaccggaaa     2760

aagtctttga cttcctgctt ggtgaccttc ccaaagtcat gatccagacg gcgggtgagt     2820

tcaaatttga acatccggtc ttgcaacggc tgctggtgtt cgaaggtcgt tgagttcccg     2880

tcaatcacgg cgcacatgtt ggtgttggag gtgacgatca cgggagtcgg gtctatctgg     2940

gccgaggact tgcatttctg gtccacgcgc accttgcttc ctccgagaat ggctttggcc     3000

gactccacga ccttggcggt catcttcccc tcctcccacc agatcaccat cttgtcgaca     3060

cagtcgttga agggaaagtt ctcattggtc cagttgacgc agccgtagaa agggcgaatt     3120

c                                                                     3121


<210> 4754
<211> 2211
<212> DNA
<213> Adeno-associated virus

<400> 4754
atggctgctg acggttatct tccagattgg ctcgaggaca acctttctga aggcattcgt       60

gagtggtggg ctctgaaacc tggagtccct caacccaaag cgaaccaaca acaccaggac      120

aaccgtcggg gtcttgtgct tccgggttac aaatacctcg gacccggtaa cggactcgac      180

aaaggagagc cggtcaacga ggcggacgcg gcagccctcg aacacgacaa agcttacgac      240

cagcagctca aggccggtga caacccgtac ctcaagtaca accacgccga cgccgagttt      300

caggagcgtc ttcaagaaga tacgtctttt gggggcaacc ttggcagagc agtcttccag      360

gccaaaaaga ggatccttga gcctcttggt ctggttgagg aagcagctaa aacggctcct      420

ggaaagaagg gggctgtaga tcagtctcct caggaaccgg actcatcatc tggtgttggc      480

aaatcgggca aacagcctgc cagaaaaaga ctaaatttcg gtcagactgg agactcagag      540

tcagtcccag accctcaacc tctcggagaa ccaccagcag cccccacaag tttgggatct      600

aatacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca ccagaacctg ggccctgccc acttacaaca accatctcta caagcaaatc      780

tccagccaat caggagcttc aaacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact ttaacagatt ccactgccac ttctcaccac gtgactggca gcgactcatt      900

aacaacaact ggggattccg gcccaagaaa ctcagcttca agctcttcaa catccaagtt      960

agaggggtca cgcagaacga tggcacgacg actattgcca ataaccttac cagcacggtt     1020

caagtgttta cggactcgga gtatcagctc ccgtacgtgc tcgggtcggc gcaccaaggc     1080

tgtctcccgc cgtttccagc ggacgtcttc atggtccctc agtatggata cctcaccctg     1140

aacaacggaa gtcaagcggt gggacgctca tccttttact gcctggagta cttcccttcg     1200

cagatgctaa ggactggaaa taacttccaa ttcagctata ccttcgagga tgtacctttt     1260

cacagcagct acgctcacag ccagagtttg gatcgcttga tgaatcctct tattgatcag     1320

tatctgtact acctgaacag aacgcaagga acaacctctg gaacaaccaa ccaatcacgg     1380

ctgcttttta gccaggctgg gcctcagtct atgtctttgc aggccagaaa ttggctacct     1440

gggccctgct accggcaaca gagactttca aagactgcta acgacaacaa caacagtaac     1500

tttccttgga cagcggccag caaatatcat ctcaatggcc gcgactcgct ggtgaatcca     1560

ggaccagcta tggccagtca caaggacgat gaagaaaaat ttttccctat gcacggcaat     1620

ctaatatttg gcaaagaagg gacaacggca agtaacgcag aattagataa tgtaatgatt     1680

acggatgaag aagagattcg taccaccaat cctgtggcaa cagagcagta tggaactgtg     1740

gcaaataact tgcagagctc aaatacagct cccacgactg gaactgtcaa tcatcagggg     1800

gccttacctg gcatggtgtg gcaagatcgt gacgtgtacc ttcaaggacc tatctgggca     1860

aagattcctc acacggatgg acactttcat ccttctcctc tgatgggagg ctttggactg     1920

aaacatccgc ctcctcaaat catgatcaaa aatactccgg taccggcaaa tcctccgacg     1980

actttcagcc cggccaagtt tgcttcattt atcactcagt actccactgg acaggtcagc     2040

gtggaaattg agtgggagct acagaaagaa aacagcaaac gttggaatcc agagattcag     2100

tacacttcca actacaacaa gtctgttaat gtggacttta ctgtagacac taatggtgtt     2160

tatagtgaac ctcgccctat tggaacccgg tatctcacac gaaacttgtg a              2211


<210> 4755
<211> 737
<212> PRT
<213> Adeno-associated virus

<400> 4755
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asn Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Asn Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Ala Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Val Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Glu Gln Ile Ser Ser Glu Thr Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Arg Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Ser 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asp Pro Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Ser Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Thr Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Ile Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asp Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Glu Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 4756
<211> 2211
<212> DNA
<213> Adeno-associated virus

<400> 4756
atggctgctg acggttatct tccagattgg ctcgaggaca acctttctga aggcattcgt       60

gagtggtggg ctctgaaacc tggagtccct caacccaaag cgaaccaaca acaccaggac      120

aaccgtcggg gtcttgtgct tccgggttac aaatacctcg gacccggtaa cggactcgac      180

aaaggagagc cggtcaacga ggcggacgcg gcagccctcg aacacgacaa agcttacgac      240

cagcagctca aggccggtga caacccgtac ctcaagtaca accacgccga cgccgagttt      300

caggagcgtc ttcaagaaga tacgtctttt gggggcaacc ttggcagagc agtcttccag      360

gccaaaaaga ggatccttga gcctcttggt ctggttgagg aagcagctaa aacggctcct      420

ggaaagaagg gggctgtaga tcagtctcct caggaaccgg actcatcatc tggtgttggc      480

aaatcgggca aacagcctgc cagaaaaaga ctaaatttcg gtcagactgg agactcagag      540

tcagtcccag accctcaacc tctcggagaa ccaccagcag cccccacaag tttgggatct      600

aatacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca ccagaacctg ggccctgccc acttacaaca accatctcta caagcaaatc      780

tccagccaat caggagcttc aaacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact ttaacagatt ccactgccac ttctcaccac gtgactggca gcgactcatt      900

aacaacaact ggggattccg gcccaagaaa ctcagcttca agctcttcaa catccaagtt      960

agaggggtca cgcagaacga tggcacgacg actattgcca ataaccttac cagcacggtt     1020

caagtgttta cggactcgga gtatcagctc ccgtacgtgc tcgggtcggc gcaccaaggc     1080

tgtctcccgc cgtttccagc ggacgtcttc atggtccctc agtatggata cctcaccctg     1140

aacaacggaa gtcaagcggt gggacgctca tccttttact gcctggagta cttcccttcg     1200

cagatgctaa ggactggaaa taacttccaa ttcagctata ccttcgagga tgtacctttt     1260

cacagcagct acgctcacag ccagagtttg gatcgcttga tgaatcctct tattgatcag     1320

tatctgtact acctgaacag aacgcaagga acaacctctg gaacaaccaa ccaatcacgg     1380

ctgcttttta gccaggctgg gcctcagtct atgtctttgc aggccagaaa ttggctacct     1440

gggccctgct accggcaaca gagactttca aagactgcta acgacaacaa caacagtaac     1500

tttccttgga cagcggccag caaatatcat ctcaatggcc gcgactcgct ggtgaatcca     1560

ggaccagcta tggccagtca caaggacgat gaagaaaaat ttttccctat gcacggcaat     1620

ctaatatttg gcaaagaagg gacaacggca agtaacgcag aattagataa tgtaatgatt     1680

acggatgaag aagagattcg taccaccaat cctgtggcaa cagagcagta tggaactgtg     1740

gcaaataact tgcagagctc aaatacagct cccacgactg gaactgtcaa tcatcagggg     1800

gccttacctg gcatggtgtg gcaagatcgt gacgtgtacc ttcaaggacc tatctgggca     1860

aagattcctc acacggatgg acactttcat ccttctcctc tgatgggagg ctttggactg     1920

aaacatccgc ctcctcaaat catgatcaaa aatactccgg taccggcaaa tcctccgacg     1980

actttcagcc cggccaagtt tgcttcattt atcactcagt actccactgg acaggtcagc     2040

gtggaaattg agtgggagct acagaaagaa aacagcaaac gttggaatcc agagattcag     2100

tacacttcca actacaacaa gtctgttaat gtggacttta ctgtagacac taatggtgtt     2160

tatagtgaac ctcgccctat tggaacccgg tatctcacac gaaacttgta a              2211


<210> 4757
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 4757
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Val Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Arg Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Gly 
    130                 135                 140                 


Ala Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Arg Gly Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 4758
<211> 728
<212> PRT
<213> Adeno-associated virus

<400> 4758
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Arg Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro Ala Gly Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210> 4759
<211> 728
<212> PRT
<213> Adeno-associated virus

<400> 4759
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro Ala Gly Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Arg Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asp Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210> 4760
<211> 685
<212> PRT
<213> Adeno-associated virus

<400> 4760
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Thr Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ala Arg Thr Gln Ser Thr Thr Gly Ser Thr Arg Gly Leu Gln Phe His 
    450                 455                 460                 


Gln Ala Gly Pro Asn Thr Met Ala Glu Gln Ser Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Asn Ile Asp Ser Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Thr Asn Pro Gly Val Ala Met Ala Thr Asn Lys 
        515                 520                 525             


Asp Asp Glu Asp Gln Phe Phe Pro Ile Asn Gly Val Leu Val Phe Gly 
    530                 535                 540                 


Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu Met Thr 
545                 550                 555                 560 


Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Glu Tyr 
                565                 570                 575     


Gly Val Val Ser Ser Asn Leu Gln Ser Ser Thr Ala Gly Pro Gln Thr 
            580                 585                 590         


Gln Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asn 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Tyr Thr Ser Asn Tyr Tyr Lys 
                645                 650                 655     


Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Thr Tyr Ser Glu 
            660                 665                 670         


Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
        675                 680                 685 


<210> 4761
<211> 733
<212> PRT
<213> Adeno-associated virus

<400> 4761
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro Ala Gly Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp Asn Thr Tyr Phe Gly 
            260                 265                 270         


Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His 
        275                 280                 285             


Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe 
    290                 295                 300                 


Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu 
305                 310                 315                 320 


Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn Asn Leu Thr Ser 
                325                 330                 335     


Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu 
            340                 345                 350         


Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe 
        355                 360                 365             


Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ala 
    370                 375                 380                 


Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met 
385                 390                 395                 400 


Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Gln Phe Glu Asp Val 
                405                 410                 415     


Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met 
            420                 425                 430         


Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr Gln Ser 
        435                 440                 445             


Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu Phe Ser Gln Ala Gly 
    450                 455                 460                 


Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp Leu Pro Gly Pro Cys 
465                 470                 475                 480 


Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Ser Gln Asn Asn Asn Ser 
                485                 490                 495     


Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asp 
            500                 505                 510         


Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr His Lys Gly Asp Glu 
        515                 520                 525             


Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met Phe Gly Lys Gln Gly 
    530                 535                 540                 


Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val Met Leu Thr Ser Glu 
545                 550                 555                 560 


Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly Val 
                565                 570                 575     


Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala Pro Ile Val Gly Ala 
            580                 585                 590         


Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp 
        595                 600                 605             


Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly 
    610                 615                 620                 


Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro 
625                 630                 635                 640 


Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro 
                645                 650                 655     


Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe Ile Thr Gln Tyr Ser 
            660                 665                 670         


Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn 
        675                 680                 685             


Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys 
    690                 695                 700                 


Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Thr Tyr Ser Glu 
705                 710                 715                 720 


Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Ser Leu 
                725                 730             


<210> 4762
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4762
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Pro Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Arg Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4763
<211> 733
<212> PRT
<213> Adeno-associated virus

<400> 4763
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Arg Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro Ala Gly Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp Asn Thr Tyr Phe Gly 
            260                 265                 270         


Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His 
        275                 280                 285             


Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe 
    290                 295                 300                 


Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu 
305                 310                 315                 320 


Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn Asn Leu Thr Ser 
                325                 330                 335     


Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu 
            340                 345                 350         


Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe 
        355                 360                 365             


Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ala 
    370                 375                 380                 


Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met 
385                 390                 395                 400 


Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Gln Phe Glu Asp Val 
                405                 410                 415     


Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met 
            420                 425                 430         


Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr Gln Ser 
        435                 440                 445             


Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu Phe Ser Gln Ala Gly 
    450                 455                 460                 


Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp Leu Pro Gly Pro Cys 
465                 470                 475                 480 


Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Ser Gln Asn Asn Asn Ser 
                485                 490                 495     


Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asp 
            500                 505                 510         


Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr His Lys Gly Asp Glu 
        515                 520                 525             


Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met Phe Gly Lys Gln Gly 
    530                 535                 540                 


Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val Met Leu Thr Ser Glu 
545                 550                 555                 560 


Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly Val 
                565                 570                 575     


Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala Pro Ile Val Gly Ala 
            580                 585                 590         


Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp 
        595                 600                 605             


Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly 
    610                 615                 620                 


Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro 
625                 630                 635                 640 


Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro 
                645                 650                 655     


Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe Ile Thr Gln Tyr Ser 
            660                 665                 670         


Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn 
        675                 680                 685             


Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys 
    690                 695                 700                 


Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Thr Tyr Ser Glu 
705                 710                 715                 720 


Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730             


<210> 4764
<211> 3098
<212> DNA
<213> Adeno-associated virus

<400> 4764
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaagg tgcgcgtgga ccaaaagtgc aagtcttccg      180

cccagatcga tcccaccccc gtgatcgtca cttccaacac caacatgtgc gctgtgattg      240

acgggaacag caccaccttc gagcaccagc agccgttaca agaccggatg ttcaaatttg      300

aactcacccg ccgtctggag cacgactttg gcaaggtgac aaagcaggaa gtcaaagagt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca tgagttctac gtcagaaagg      420

gtggagccaa caagagaccc gcccccgatg acgcggataa aagcgagccc aagcgggcct      480

gcccctcagt cgcggatcca tcgacgtcag acgcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg tttccctgca      600

agacatgcga gagaatgaat cagaatttca acatttgctt cacgcacggg accagagact      660

gttcagaatg tttccccggc gtgtcagaat ctcaaccggt cgtcagaaag aggacgtatc      720

ggaaactctg tgccattcat catctgctgg ggcgggctcc cgagattgct tgctcggcct      780

gcgatctggt caacgtggac ctggatgacc gtgtttctga gcaataaatg acttaaacca      840

ggtatggctg ccgatggtta tcttccagat tggctcgagg acaacctctc tgagggcatt      900

cgcgagtggt gggacttgaa acctggagcc ccgaaaccca aagccaacca gcaaaagcag      960

gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt caacggactc     1020

gacaagggag agccggtcaa cgaggcagac gccgcggccc tcgagcacga caaggcctac     1080

gacaagcagc tcgagcaggg ggacaacccg tacctcaagt acaaccacgc cgacgccgag     1140

tttcaggagc gtcttcaaga agatacgtct tttgggggca acctcgggcg agcagtcttc     1200

caggccaaga agcgggttct cgaacctctc ggtctggttg aggaaggcgc taagacggct     1260

cctggaaaga agagacccat agaatccccc gactcctcca cgggcatcgg caagaaaggc     1320

cagcagcccg ctaaaaagaa gctcaacttt gggcagactg gcgactcaga gtcagtgccc     1380

gacccccaac ctctcggaga acctcccgcc gcgccctcag gtctgggatc tggtacaatg     1440

gctgcaggcg gtggcgcacc aatggcagac aataacgaag gcgccgacgg agtgggtaat     1500

gcctccggaa attggcattg cgattccaca tggctgggcg acagagtcat caccaccagc     1560

acccgcacct gggccctgcc cacctacaac aaccacctct acaagcagat atcaagtcag     1620

agcggggcta ccaacgacaa ccacttcttc ggctacagca ccccctgggg ctattttgac     1680

ttcaacagat tccactgcca cttctcacca cgtgactggc agcgactcat caacaacaac     1740

tggggattcc ggcccagaaa gctgcggttc aagttgttca acatccaggt caaggaggtc     1800

acgacgaacg acggcgttac gaccatcgct aataacctta ccagcacgat tcaggtcttc     1860

tcggactcgg agtaccaact gccgtacgtc ctcggctctg cgcaccaggg ctgcctccct     1920

ccgttccctg cggacgtgtt catgattcct cagtacggat atctgactct aaacaacggc     1980

agtcagtctg tgggacgttc ctccttctac tgcctggagt actttccttc tcagatgctg     2040

agaacgggca ataactttga attcagctac acctttgagg aagtgccttt ccacagcagc     2100

tatgcgcaca gccagagcct ggaccggctg atgaatcccc tcatcgacca gtacctgtac     2160

tacctggccc ggacccagag cactacgggg tccacaaggg agctgcagtt ccatcaggct     2220

gggcccaaca ccatggccga gcaatcaaag aactggctgc ccggaccctg ttatcggcag     2280

cagagactgt caaaaaacat agacagcaac aacaacagta actttgcctg gaccggggcc     2340

actaaatacc atctgaatgg tagaaattca ttaaccaacc cgggcgtagc catggccacc     2400

aacaaggacg acgaggacca gttctttccc atcaacggag tgctggtttt tggcgaaacg     2460

ggggctgcca acaagacaac gctggaaaac gtgctaatga ccagcgagga ggagatcaaa     2520

accaccaatc ccgtggctac agaagaatac ggtgtggtct ccagcaacct gcaatcgtct     2580

acggccggac cccagacaca gactgtcaac agccaggggg ctctgcccgg catggtctgg     2640

cagaaccggg acgtgtacct gcagggtccc atctgggcca aaattcctca cacggacggc     2700

aactttcacc cgtctcccct gatgggcgga tttggactca aacacccgcc tcctcaaatt     2760

ctcatcaaaa acaccccggt acctgctaat cctccagagg tgtttactcc tgccaagttt     2820

gcctcattta tcacgcagta cagcaccggc caggtcagcg tggagatcga gtgggaactg     2880

cagaaagaaa acagcaaacg ctggaatcca gagattcagt acacctcaaa ttatgccaag     2940

tctaataatg tggaatttgc tgtcaacaac gaaggggttt atactgagcc tcgccccatt     3000

ggcacccgtt acctcacccg taacctgtaa ttgcctgtta atcaataaac cggttaattc     3060

gtttcagttg aactttggtc tctgcgaagg gcgaattc                             3098


<210> 4765
<211> 728
<212> PRT
<213> Adeno-associated virus

<400> 4765
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Glu Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210> 4766
<211> 733
<212> PRT
<213> Adeno-associated virus

<400> 4766
Met Ala Ala Asp Gly His Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro Ala Gly Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp Asn Thr Tyr Phe Gly 
            260                 265                 270         


Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His 
        275                 280                 285             


Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Ser Trp Gly Phe 
    290                 295                 300                 


Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu 
305                 310                 315                 320 


Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn Asn Leu Thr Ser 
                325                 330                 335     


Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu 
            340                 345                 350         


Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe 
        355                 360                 365             


Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ala 
    370                 375                 380                 


Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met 
385                 390                 395                 400 


Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Gln Phe Glu Asp Val 
                405                 410                 415     


Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met 
            420                 425                 430         


Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr Gln Ser 
        435                 440                 445             


Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu Phe Ser Gln Ala Gly 
    450                 455                 460                 


Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp Leu Pro Gly Pro Cys 
465                 470                 475                 480 


Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser Gln Asn Asn Asn Ser 
                485                 490                 495     


Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asp 
            500                 505                 510         


Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr His Lys Asp Asp Glu 
        515                 520                 525             


Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met Phe Gly Lys Gln Gly 
    530                 535                 540                 


Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val Met Leu Thr Ser Glu 
545                 550                 555                 560 


Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly Val 
                565                 570                 575     


Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala Pro Ile Val Gly Ala 
            580                 585                 590         


Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp 
        595                 600                 605             


Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly 
    610                 615                 620                 


Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro 
625                 630                 635                 640 


Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro 
                645                 650                 655     


Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe Ile Thr Gln Tyr Ser 
            660                 665                 670         


Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn 
        675                 680                 685             


Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys 
    690                 695                 700                 


Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Thr Tyr Ser Glu 
705                 710                 715                 720 


Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730             


<210> 4767
<211> 2495
<212> DNA
<213> Adeno-associated virus

<400> 4767
gaattcgccc tttctacggc tgcgtcaact agaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattcatcat ctgctggggc gggctcccga gattgcttgc tcggcctgcg      180

atctggtcaa cgtggacctg gatgactgtg tttctgagca ataaatgact taaaccaggt      240

atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc      300

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      360

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      420

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      480

aagcagctcg agcaggggga caacccgtac ctcaagtaca accacgccga cgccgagttt      540

caggagcgtc ttcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      600

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      660

ggaaagaaga gacccataga atcccccgac tcctccacgg gcatcggcaa gaaaggccag      720

cagcccgcta aaaagaagct caactttggg cagactggcg actcagagtc agtgcccgac      780

cctcaaccaa tcggagaacc ccccgcaggc ccctctggtc tgggatctgg tacaatggct      840

gcaggcggtg gcgctccaat ggcagacaat aacgaaggcg ccgacggagt gggtaatgcc      900

tccggaaatt ggcattgcga ttccacatgg ctgggcgaca gagtcatcac caccagcacc      960

cgcacctggg ccctgcccac ctacaacaac cacctctaca agcagatatc aagtcagagc     1020

ggggctacca acgacaacca cttcttcggc tacagcaccc cctggggcta ttttgacttc     1080

aacagattcc actgccactt ctcaccacgt gactggcagc gactcatcaa caacaactgg     1140

ggattccggc ccagaaagct gcggttcaag ttgttcaaca tccaggtcaa ggaggtcacg     1200

acgaacgacg gcgttacgac catcgctaat aaccttacca gcacgattca ggtcttctcg     1260

gactcggagt accaactgcc gtacgtcctc ggctctgcgc accagggctg cctccctccg     1320

ttccctgcgg acgtgttcat gattcctcag tacggatatc tgactctaaa caacggcagt     1380

cagtctgtgg gacgttcctc cttctactgc ctggagtact ttccttctca gatgctgaga     1440

acgggcaata actttgaatt cagctacacc tttgaggaag tgcctttcca cagcagctat     1500

gcgcacagcc agagcctgga ccggctgatg aatcccctca tcgaccagta cctgtactac     1560

ctggcccgga cccagagcac tacggggtcc acaagggagc tgcagttcca tcaggctggg     1620

cccaacacca tggccgagca atcaaagaac tggctgcccg gaccctgtta tcggcagcag     1680

agactgtcaa aaaacataga cagcaacaac accagtaact ttgcctggac cggggccact     1740

aaataccatc tgaatggtag aaattcatta accaacccgg gcgtagccat ggccaccaac     1800

aaggacgacg aggaccagtt ctttcccatc aacggagtgc tggtttttgg caaaacgggg     1860

gctgccaaca agacaacgct ggaaaacgtg ctaatgacca gcgaggagga gatcaaaacc     1920

accaatcccg tggctacaga acagtacggt gtggtctcca gcaacctgca atcgtctacg     1980

gccggacccc agacacagac tgtcaacagc cagggggctc tgcccggcat ggtctggcag     2040

aaccgggacg tgtacctgca gggtcccatc tgggccaaaa ttcctcacac ggacggcaac     2100

tttcacccgt ctcccctgat gggcggattt ggactcaaac acccgcctcc tcaaattctc     2160

atcaaaaaca ccccggtacc tgctaatcct ccagaggtgt ttactcctgc caagtttgcc     2220

tcatttatca cgcagtacag caccggccag gtcagcgtgg agatcgagtg ggaactgcag     2280

aaagaaaaca gcaaacgctg gaatccagag attcagtaca cctcaaatta tgccaagtct     2340

aataatgtgg aatttgctgt caacaacgaa ggggtttata ctgagcctcg ccccattggc     2400

acccgttacc tcacccgtaa cctgtaattg cctgttaatc aataaaccgg ttaattcgtt     2460

tcagttgaac tttggtctct gcgaagggcg aattc                                2495


<210> 4768
<211> 728
<212> PRT
<213> Adeno-associated virus

<400> 4768
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro Ala Gly Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Thr Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210> 4769
<211> 2504
<212> DNA
<213> Adeno-associated virus

<400> 4769
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattcatcat ctgctggggc gggctcccga gattgcttgc tcggcctgcg      180

atctggtcaa cgtggacctg gatgactgtg tttctgagca ataaatgact taaaccaggt      240

atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc      300

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      360

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      420

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      480

aagcagctcg agcaggggga caacccgtac ctcaagtaca accacgccga cgccgagttt      540

caggagcgtc ttcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      600

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      660

ggaaagaaga gacccataga atcccccgac tcctccacgg gcatcggcaa gaaaggccag      720

cagcccgcta aaaagaagct caactttggg cagactggcg actcagagtc agtgcccgac      780

cctcaaccaa tcggagaacc ccccgcaggc ccctctggtc tgggatctgg tacaatggct      840

gcaggcggtg gcgctccaat ggcagacaat aacgaaggcg ccgacggagt gggtaatgcc      900

tccggaaatt ggcattgcga ttccacatgg ctgggcgaca gagtcatcac caccagcacc      960

cgcacctggg ccctgcccac ctacaacaac cacctctaca agcagatatc aagtcagagc     1020

ggggctacca acgacaacca cttcttcggc tacagcaccc cctggggcta ttttgacttc     1080

aacagattcc actgccactt ctcatcacgt gactggcagc gactcatcaa caacaactgg     1140

ggattccggc ccaagagact caacttcaag ctcttcaaca tccaggtcaa ggaggtcacg     1200

cagaatgaag gcaccaagac catcgccaat aaccttacca gcacgattca ggtctttacg     1260

gactcggaat accggctccc gtacgtcctc ggctctgcgc accagggctg cctgcctccg     1320

ttcccggcgg acgtcttcat gattcctcag tacgggtacc tgactctgaa caacggcagt     1380

caggccgtgg gccgttcctc cttctactgc ctggagtact ttccttctca aatgctgaga     1440

acgggcaaca actttgagtt cagctaccag tttgaggacg tgccttttca cagcagctac     1500

gcgcacagcc aaagcctgga ccggctgatg aaccccctca tcgaccagta cctgtactac     1560

ctgtctcgga ctcagtccac gggaggtacc gcaggaactc agcagttgct attttctcag     1620

gccgggccta ataacatgtc ggctcaggcc aaaaactggc tacccgggcc ctgctaccgg     1680

cagcaacgcg tctccacgac actgtcgcaa aataacaaca gcaactttgc ttggaccggt     1740

gccaccaagt atcatctgaa tggcagagac tctctggtaa atcccggtgt cgctatggca     1800

acgcacaagg acgacgaaga gcgatttttt ccatccagcg gagtcttgat gtttgggaaa     1860

cagggagctg gaaaagacaa cgtggactat agcagcgtta tgctaaccag tgaggaagaa     1920

atcaaaacca ccaacccagt ggccacagaa cagtacggcg tggtggccga taacctgcaa     1980

cagcaaaacg ccgctcctat tgtaggggcc gtcaacagtc aaggagcctt acctggcatg     2040

gtctggcaga accgggacgt gtacctgcag ggtcctatct gggccaagat tcctcacacg     2100

gacggcaact ttcatccttc gccgctgatg ggaggctttg gactgaaaca cccgcctcct     2160

cagatcctga ttaagaatac acctgttccc gcggatcctc caactacctt cagtcaagcc     2220

aagccggcgt cgttcatcac gcagtacagc accggacagg tcagcgtgga aattgaatgg     2280

gagctgcaga aagagaacag caagcgctgg aacccagaga ttcagtatac ttccaactac     2340

tacaaatcta caaatgtgga ctttgctgtc aatactgagg gtacttattc agagcctcgc     2400

cccattggca cccgttacct cacccgtaac ctgtaattgc ctgttaatca ataaaccggt     2460

taattcgttt cagttgaact ttggtctctg cgaagggcga attc                      2504


<210> 4770
<211> 731
<212> PRT
<213> Adeno-associated virus

<400> 4770
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro Ala Gly Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Ser Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Thr Asp Ser Glu Tyr Arg Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ala Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Gln Phe Glu Asp Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr Gln Ser Thr Gly 
        435                 440                 445             


Gly Thr Ala Gly Thr Gln Gln Leu Leu Phe Ser Gln Ala Gly Pro Asn 
    450                 455                 460                 


Asn Met Ser Ala Gln Ala Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg 
465                 470                 475                 480 


Gln Gln Arg Val Ser Thr Thr Leu Ser Gln Asn Asn Asn Ser Asn Phe 
                485                 490                 495     


Ala Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asp Ser Leu 
            500                 505                 510         


Val Asn Pro Gly Val Ala Met Ala Thr His Lys Asp Asp Glu Glu Arg 
        515                 520                 525             


Phe Phe Pro Ser Ser Gly Val Leu Met Phe Gly Lys Gln Gly Ala Gly 
    530                 535                 540                 


Lys Asp Asn Val Asp Tyr Ser Ser Val Met Leu Thr Ser Glu Glu Glu 
545                 550                 555                 560 


Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly Val Val Ala 
                565                 570                 575     


Asp Asn Leu Gln Gln Gln Asn Ala Ala Pro Ile Val Gly Ala Val Asn 
            580                 585                 590         


Ser Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr 
        595                 600                 605             


Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe 
    610                 615                 620                 


His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro 
625                 630                 635                 640 


Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Thr 
                645                 650                 655     


Phe Ser Gln Ala Lys Pro Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly 
            660                 665                 670         


Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys 
        675                 680                 685             


Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Thr 
    690                 695                 700                 


Asn Val Asp Phe Ala Val Asn Thr Glu Gly Thr Tyr Ser Glu Pro Arg 
705                 710                 715                 720 


Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730     


<210> 4771
<211> 731
<212> PRT
<213> Adeno-associated virus

<400> 4771
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Arg Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Arg Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Gln Phe Glu Asp Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr Gln Ser Thr Gly 
        435                 440                 445             


Gly Thr Ala Gly Thr Gln Gln Leu Leu Phe Ser Gln Ala Gly Pro Asn 
    450                 455                 460                 


Asn Met Ser Ala Gln Ala Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg 
465                 470                 475                 480 


Gln Gln Arg Val Ser Thr Thr Leu Ser Gln Asn Asn Asn Ser Asn Phe 
                485                 490                 495     


Ala Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asp Ser Leu 
            500                 505                 510         


Val Asn Pro Gly Val Ala Met Ala Thr His Lys Asp Asp Glu Glu Arg 
        515                 520                 525             


Phe Phe Pro Ser Ser Gly Val Leu Met Phe Gly Lys Gln Gly Ala Gly 
    530                 535                 540                 


Lys Asp Asn Val Asp Tyr Ser Ser Val Met Leu Thr Ser Glu Glu Glu 
545                 550                 555                 560 


Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly Val Val Ala 
                565                 570                 575     


Asp Asn Leu Gln Gln Gln Asn Ala Ala Pro Ile Val Gly Ala Val Asn 
            580                 585                 590         


Ser Gln Gly Ala Leu Pro Gly Met Ala Trp Gln Asn Arg Asp Val Tyr 
        595                 600                 605             


Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe 
    610                 615                 620                 


His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro 
625                 630                 635                 640 


Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Thr 
                645                 650                 655     


Phe Ser Gln Ala Lys Leu Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly 
            660                 665                 670         


Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys 
        675                 680                 685             


Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Thr 
    690                 695                 700                 


Asn Val Asp Phe Ala Val Asn Thr Glu Gly Thr Tyr Ser Glu Pro Arg 
705                 710                 715                 720 


Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730     


<210> 4772
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4772
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4773
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4773
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Arg Lys Leu Arg Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Thr Asp Asp Gly Val Thr Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Ser Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ala Arg Thr Gln Ser Thr Thr Gly Ser Thr Arg Glu Leu Gln Phe His 
    450                 455                 460                 


Gln Ala Gly Pro Asn Thr Met Ala Glu Gln Ser Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Asn Ile Asp Ser Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Thr Asn Pro Gly Val Ala Met Ala Thr Asn Lys 
        515                 520                 525             


Asp Asp Glu Asp Gln Phe Phe Pro Ile Asn Gly Val Leu Val Phe Gly 
    530                 535                 540                 


Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu Met Thr 
545                 550                 555                 560 


Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Glu Tyr 
                565                 570                 575     


Gly Val Val Ser Ser Asn Leu Gln Ser Ser Thr Ala Gly Pro Gln Thr 
            580                 585                 590         


Gln Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asn 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly Asn Phe His Pro Ser Pro Leu Met Asp Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Ala Lys Ser Asn Asn Val Glu Phe Ala Val Asn Asn Glu Gly Val Tyr 
705                 710                 715                 720 


Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4774
<211> 3128
<212> DNA
<213> Adeno-associated virus

<400> 4774
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaagg tgcgcgtgga ccaaaagtgc aagtcttccg      180

cccagatcga tcccaccccc gtgatcgtca cttccaacac caacatgtgc gccgtgattg      240

acgggaacag caccaccttc gagcaccagc agccgttaca agaccggatg ttcaaatttg      300

aactcacccg ccgtctggag cacgactttg gcaaggtgac aaagcaggaa gtcaaagagt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca tgagttctac gtcagaaagg      420

gtggagccaa caagagaccc gcccccgatg acgcggataa aagcgagccc aagcgggcct      480

gcccctcagt cgcggatcca tcgacgtcag acgcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg tttccctgca      600

agacatgcga gagaatgaat cagaatttca acatttgctt cacgcacggg accagagact      660

gttcagaatg tttccccggc gtgtcagaat ctcaaccggt cgtcagaaag aggacgtatc      720

ggaaactctg tgccattcat catctgctag ggcgggctcc cgagattgct tgctcggcct      780

gcgatctggt caacgtggac ctggatgact gtgtttctga gcaataaatg acttaaacca      840

ggtatggctg ccgatggtta tcttccagat tggctcgagg acaacctctc tgagggcatt      900

cgcgagtggt gggacttgaa acctggagcc ccgaaaccca aagccaacca gcaaaagcag      960

gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt caacggactc     1020

gacaaggggg agcccgtcaa cgcggcggac gcagcggccc tcgagcacga caaggcctac     1080

gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc cgacgccgag     1140

tttcaggagc gtctgcaaga agatacgtct tttgggggca acctcgggcg agcagtcttc     1200

caggccaaga agcgggttct cgaacctctc ggtctggttg aggaaggcgc taagacggct     1260

cctggaaaga agagaccggt agagccatca ccccagcgtt ctccagactc ctctacgggc     1320

atcggcaaga caggccagca gcccgcgaaa aagagactca actttgggca gactggcgac     1380

tcagagtcag tgcccgaccc tcaaccaatc ggagaacccc ccgcaggccc ctctggtctg     1440

ggatctggta caatggctgc aggcggtggc gctccaatgg cagacaataa cgaaggcgcc     1500

gacggagtgg gtagttcctc aggaaattgg cattgcgatt ccacatggct gggcgacaga     1560

gtcatcacca ccagcacccg aacctgggcc ctccccacct acaacaacca cctctacaag     1620

caaatctcca acgggacatc gggaggaagc accaacgaca acacctactt cggctacagc     1680

accccctggg ggtattttga ctttaacaga ttccactgcc acttctcacc acgtgactgg     1740

cagcgactca tcaacaacaa ctggggattc cggcccaaga gactcaactt caagctcttc     1800

aacatccagg tcaaggaggt cacgcagaat gaaggcacca agaccatcgc caataacctt     1860

accagcacga ttcaggtctt tacggactcg gaataccagc tcccgtacgt cctcggctct     1920

gcgcaccagg gctgcctgcc tccgttcccg gcggacgtct tcatgattcc tcagtacggg     1980

tacctgactc tgaacaacgg cagtcaggcc gtgggccgtt cctccttcta ctgcctggag     2040

tactttcctt ctcaaatgct gagaacgggc aacaactttg agttcagcta ccagtttgag     2100

gacgtgcctt ttcacagcag ctacgcgcac agccaaagcc tggaccggct gatgaacccc     2160

ctcatcgacc agtacctgta ctacctgtct cggactcagt ccacgggagg taccgcagga     2220

actcagcagt tgctattttc tcaggccggg cctaataaca tgtcggctca ggccaaaaac     2280

tggctacccg ggccctgcta ccggcagcaa cgcgtctcca cgacactgtc gcaaaataac     2340

aacagcaact ttgcttggac cggtgccacc aagtatcatc tgaatggcag agactctctg     2400

gtaaatcccg gtgtcgctat ggcaacgcac aaggacgacg aagagcgatt ttttccatcc     2460

agcggagtct tgatgtttgg gaaacaggga gctggaaaag acaacgtgga ctatagcagc     2520

gttatgctaa ccagtgagga agaaatcaaa accaccaacc cagtggccac agaacagtac     2580

ggcgtggtgg ccgataacct gcaacagcaa aacgccgctc ctattgtagg ggccgtcaac     2640

agtcaaggag ccttacctgg catggtctgg cagaaccggg acgtgtacct gcagggtcct     2700

atctgggcca agattcctca cacggacggc aactttcatc cttcgccgct gatgggaggc     2760

tttggactga aacacccgcc tcctcagatc ctgattaaga atacacctgt tcccgcggat     2820

cctccaacta ccttcagtca agccaagctg gcgtcgttca tcacgcagta cagcaccgga     2880

caggtcagcg tggaaattga atgggagctg cagaaagaga acagcaagcg ctggaaccca     2940

gagattcagt atacttccaa ctactacaaa tctacaaatg tggactttgc tgtcaatact     3000

gagggtactt attcagagcc tcgccccatt ggcacccgtt acctcacccg taacctgtaa     3060

ttgcctgtta atcaataaac cggctaattc gtttcagttg aactttggtc tctgcgaagg     3120

gcgaattc                                                              3128


<210> 4775
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4775
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4776
<211> 3084
<212> DNA
<213> Adeno-associated virus

<400> 4776
gaattcgccc tttctacggc tgcatcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaagg tgcgcgtgga ccaaaagtgc aagtcgtccg      180

cccagatcga ccccaccccc gtgatcgtca cctccaacac caacatgtgc gccgtgattg      240

acgggaacag caccaccttc gagcaccagc agccgttgca ggaccggatg ttcaagttcg      300

aactcacccg ccgtctggag cacgactttg gcaaggtgac caagcaggaa gtcaaagagt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca tgagttctac gtcagaaagg      420

gcggagccag caaaagaccc gcccccgatg acgcggatat aagcgagccc aagcgggcct      480

gcccctcagt cgcggatcca tcgacgtcag acgcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg tttccctgca      600

aaacgtgcga gaaaatgaat cagaatttca acatttgctt cacgcacggg gtcagagact      660

gctcagaatg tttccccggt gcatcagaat ctcaaccggt cgtcagaaaa aaaacgtatc      720

agaaactgtg tgccattcat catctgctgg ggcgggcacc cgagattgct tgctcggcct      780

gcgatctggt caacgtggac ctggacgact gtgtttctga gcaataaatg acttaaacca      840

ggtatggctg ccgatggtta tcttccagat tggcttgagg acaacctctc tgagggcatt      900

cgcgagtggt gggacctgaa acctggagcc ccgaaaccca aagccaacca gcaaaagcag      960

gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt caacggactc     1020

gacaaggggg agcccgtcaa cgcggcggac gcagcggccc tcgagcacga caaggcctac     1080

gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc cgacgccgag     1140

tttcaggagc gtctgcaaga agatacgtct tttgggggca acctcgggcg agcagtcttc     1200

caggccaaga agcgggttct cgaacctctc ggtctggttg aggaaggcgc taagacggct     1260

cctggaaaga agagaccggt agagccatca cctcagcgtt cccccgactc ctccacgggc     1320

atcggcaaga aaggccacca gcccgcgaga aagagactga actttgggca gactggcgac     1380

tcggagtcag tccccgaccc tcaaccaatc ggagaaccac cagcaggccc ctctggtctg     1440

ggatctggta caatggctgc aggcggtggc gctccaatgg cagacaataa cgaaggcgcc     1500

gacggagtgg gtagttcctc aggaaattgg cattgcgatt ccacatggct gggcgacaga     1560

gtcatcacca ccagcacccg aacctgggcc ctgcccacct acaacaacca tctctacaag     1620

caaatctcca acgggacatc gggaggaagc actaacgaca acacctactt tggctacagc     1680

accccctggg ggtattttga cttcaacaga ttccactgcc acttctcacc acgtgactgg     1740

cagcgactca tcaacaataa ctggggattc cggcccaaga gactcaactt caagctcttc     1800

aacatccagg tcaaggaggt cacgcagaat gaaggcacca agaccatcgc caataacctt     1860

accagcacga ttcaggtgtt tacggactcg gaataccagc tcccgtacgt ccccggctct     1920

gcgcaccagg gctgcctccc tccgttcccg gcggacgtct tcatgattcc tcagtacggg     1980

tatctgaccc taaacaatgg cagtcaggct gtgggccgtt cctccttcta ctgcctggaa     2040

tacttccctt ctcaaatgct gaggacgggc aacaactttg aattcagcta caccttcgag     2100

gacgtgcctt tccacagcag ctacgcgcac agccagagcc tggaccggct gatgaaccct     2160

ctcatcgacc agtacctgta ttacttatcc agaactcagt ccacaggagg aactcaaggt     2220

actcagcaat tgttattttc tcaagccggg cccgcaaaca tgtcggctca ggccaagaac     2280

tggctacctg gaccgtgtta ccgtcagcaa cgagtttcca cgacactgtc gcaaaacaac     2340

aacagcaatt ttgcttggac cggtgccacc aagtatcacc tgaatggcag agactccctg     2400

gttaatcccg gcgttgccat ggctacccac aaggacgacg aggagcgctt cttcccgtca     2460

agcggagttc taatgtttgg caagcagggg gctggaaaag acaatgtgga ctacagcagc     2520

gtgatgctca ccagcgaaga agaaattaaa actactaacc cagtggctac agagcagtat     2580

ggtgtggtgg cagacaacct gcagcagacc aacggagctc ccattgtggg aactgtcaac     2640

agccaggggg ccttacctgg tatggtctgg caaaaccggg acgtgtacct gcagggcccc     2700

atctgggcca aaattcctca cacggacggc aactttcatc cttcgccgct gatgggaggc     2760

tttggactga aacacccgcc tcctcagatc ctggtgaaaa acactcctgt tcctgcggat     2820

cctccgacca ccttcagcca ggccaagctg gcttctttta tcacgcagta cagcaccgga     2880

caggtcagcg tggaaatcga atgggagctg cagaaagaaa acagcaagcg ctggaaccca     2940

gagattcagt atacttccaa ctactacaaa tctacaaatg tggactttgc tgtcaatact     3000

gagggtactt attcagagcc tcgccccatt ggcactcgtt atctcacccg taatctgtaa     3060

ttgcttgtta atcaataaac cggt                                            3084


<210> 4777
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4777
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly His Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Pro Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Gly Ala 
            580                 585                 590         


Pro Ile Val Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Val Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4778
<211> 3123
<212> DNA
<213> Adeno-associated virus

<400> 4778
gaattcgccc ttggctgcgt caactggacc aatgagaact ttcccttcaa cgattgcgtc       60

gacaagatgg tgatctggtg ggaggagggc aagatgacgg ccaaggtcgt ggagtccgcc      120

aaggccattc tcggcggcag caaggtgcgc gtggaccaaa agtgcaagtc gtccgcccag      180

atcgacccca cccccgtgat cgtcacctcc aacaccaaca tgtgcgccgt gattgacggg      240

aacagcacca ccttcgagca ccagcagccg ttgcaggacc ggatgttcaa gttcgaactc      300

acccgccgtc tggagcacga ctttggcaag gtgaccaagc aggaagtcaa agagttcttc      360

cgctgggcgc aggatcacgt gaccgaggtg gcgcatgagt tctacgtcag aaagggcgga      420

gccagcaaaa gacccgcccc cgatgacgcg gatataagcg agcccaagcg ggcctgcccc      480

tcagtcgcgg atccatcgac gtcagacgcg gaaggagctc cggtggactt tgccgacagg      540

taccaaaaca aatgttctcg tcacgcgggc atgctccaga tgctgtttcc ctgcaaaacg      600

tgcgagagaa tgaatcagaa tttcaacatt tgcttcacgc acggggtcag agactgctca      660

gaatgtttcc ccggtgcatc agaatctcaa ccggtcgtca gaaaaaaaac gtatcagaaa      720

ctgtgtgcca ttcatcatct gctggggcgg gcacccgaga ttgcttgctc ggcctgcgat      780

ctggtcaacg tggacctgga cgactgtgtt tctgagcaat aaatgactta aaccaggtat      840

ggctgccgat ggttatcttc cagattggct tgaggacaac ctctctgagg gcattcgcga      900

gtggtgggac ctgaaacctg gagccccgaa acccaaagcc aaccagcaaa agcaggacga      960

cggccggggt ctggtgcttc ctggctacaa gtacctcgga cccttcaacg gactcgacaa     1020

gggggagccc gtcaacgcgg cggacgcagc ggccctcgag cacgacaagg cctacgacca     1080

gcagctcaaa gcgggtgaca atccgtacct gcggtataac cacgccgacg ccgagtttca     1140

ggagcgtctg caagaagata cgtcttttgg gggcaacctc gggcgagcag tcttccaggc     1200

caagaagcgg gttctcgaac ctctcggtct ggttgaggaa ggcgctaaga cggctcctgg     1260

aaagaagaga ccggtagagc catcacctca gcgttccccc gactcctcca cgggcatcgg     1320

caagaaaggc caccagcccg cgagaaagag actgaacttt gggcagactg gcgactcgga     1380

gtcagtcccc gaccctcaac caatcggaga accaccagca ggcccctctg gtctgggatc     1440

tggtacaatg gctgcaggcg gtggcgctcc aatggcagac aataacgaag gcgccgacgg     1500

agtgggtagt tcctcaggaa attggcattg cgattccaca tggctgggcg acagagtcat     1560

caccaccagc acccgaacct gggccctgcc cacctacaac aaccatctct acaagcaaat     1620

ctccaacggg acatcgggag gaagcactaa cgacaacacc tactttggct acagcacccc     1680

ctgggggtat tttgacttca acagattcca ctgccacttc tcaccacgtg actggcagcg     1740

actcatcaac aataactggg gattccggcc caagagactc aacttcaagc tcttcaacat     1800

ccaggtcaag gaggtcacgc agaatgaagg caccaagacc atcgccaata accttaccag     1860

cacgattcag gtgtttacgg actcggaata ccagctcccg tacgtcctcg gctctgcgca     1920

ccagggctgc ctccctccgt tcccggcgga cgtcttcatg attcctcagt acgggtatct     1980

gaccctaaac aatggcagtc aggctgtggg ccgttcctcc ttctactgcc tggaatactt     2040

cccttctcaa atgctgagga cgggcaacaa ctttgaattc agctacacct tcgaggacgt     2100

gcctttccac agcagctacg cgcacagcca gagcctggac cggctgatga accctctcat     2160

cgaccagtac ctgtattact tatccagaac tcagtccaca ggaggaactc aaggtactca     2220

gcaattgtta ttttctcaag ccgggcccgc aaacatgtcg gctcaggcca agaactggct     2280

acctggaccg tgttaccgtc agcaacgagt ttccacgaca ctgtcgcaaa acaacaacag     2340

caattttgct tggaccggtg ccaccaagta tcacctgaat ggcagagact ccctggttaa     2400

tcccggcgtt gccatggcta cccacaagga cgacgaggag cgcttcttcc cgtcaagcgg     2460

agttctaatg tttggcaagc agggggctgg aaaagacaat gtggactaca gcagcgtgat     2520

gctcaccagc gaagaagaaa ttaaaactac taacccagtg gctacagagc agtatggtgt     2580

ggtggcagac aacctgcagc agaccaacgg agctcccatt gtgggaactg tcaacagcca     2640

gggggcctta cctggtatgg tctggcaaaa ccgggacgtg tacctgcagg gccccatctg     2700

ggccaaaatt cctcacacgg acggcaactt tcatccttcg ccgctgatgg gaggctttgg     2760

actgaaacac ccgcctcctc agatcctggt gaaaaacact cctgttcctg cggatcctcc     2820

gaccaccttc agccaggcca agctggcttc ttttatcacg cagtacagca ccggacaggt     2880

cagcgtggaa atcgaatggg agctgcagaa agaaaacagc aagcgctgga acccagagat     2940

tcagtatact tccaactact acaaatctac aaatgtggac tttgctgtca atactgaggg     3000

tacttattca gagcctcgcc ccattggcac tcgttatctc acccgtaatc tgtaattgct     3060

tgttaatcaa taaaccggtt aattcgtttc agttgaactt tggtctctgc gaagggcgaa     3120

ttc                                                                   3123


<210> 4779
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4779
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly His Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Gly Ala 
            580                 585                 590         


Pro Ile Val Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Val Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4780
<211> 3122
<212> DNA
<213> Adeno-associated virus

<400> 4780
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaagg tgcgtgtgga ccaaaagtgc aagtcttccg      180

cccagatcga tcccaccccc gtgatcgtca cctccaacac caacatgtgc gccgtgattg      240

acgggaacag cgccaccttc gagcaccagc agccgttgca ggaccggatg ttcaaatttg      300

aactcacccg ccgtctggag catgactttg gcaaggtgac gaagcaggaa gtcaaagagt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca tgagttccac gtcagaaagg      420

gtggagccaa caagagaccc gcccccgatg acgcggatat aagcgagccc aagcgggcct      480

gcccctcagt cgcggatcca tcgacgtcag acgcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg tttccctgca      600

agacatgcga gagaatgaat cagaatttca acatttgctt cacgcacggg accagagact      660

gttcagaatg tttccccggc gtgtcagaat ctcaaccggt cgtcagaaag aggacgtatc      720

ggaaactctg tgcgattcat catctgctgg ggcgggctcc cgagattgct tgctcggcct      780

gcgatctggt caacgtggac ctggatgact gtgtttctga gcaataaatg acttaaacca      840

ggtatggctg ccgatggtta tcttccagat tggctcgagg acaacctctc tgagggcatt      900

cgcgagtggt gggacttgaa acctggagcc ccgaaaccca aagccaacca gcaaaagcag      960

gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt caacggactc     1020

gacaaggggg agcccgtcaa cgcggcggac gcagcggccc tcgagcacga caaagcctac     1080

gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataatcacgc cgacgccgag     1140

tttcaggagc gtctgcaaga agatacgtct tttgggggca acctcgggcg agcagtcttc     1200

caggccaaga agcgggttct cgaacctctc ggtctggttg aggaaggcgc taagacggct     1260

cctggaaaga agagactggt agagcagtcg ccacaagagc cagactcctc ctcgggcatc     1320

ggcaagacag gccagcagcc cgctaaaaag agactcaatt ttggtcagac tggcgactca     1380

gagtcagtcc ccgacccaca acctctcgga gaacctccag cagccccctc aggtctggga     1440

cctaatacaa tggcttcagg cggtggcgct ccaatggcag acaataacga aggcgccgac     1500

ggagtgggta attcctcggg aaattggcat tgcgattcca catggctggg ggacagagtc     1560

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa     1620

atctccaacg gcacctcggg aggaagcacc aacgacaaca cctattttgg ctacagcacc     1680

ccctgggggt attttgactt caacagattc cactgtcact tttcaccacg tgactggcaa     1740

cgactcatca acaacaattg gggattccgg cccaaaagac tcaacttcaa gctgttcaac     1800

atccaggtca aggaagtcac gacgaacgaa ggcaccaaga ccatcgccaa taatctcacc     1860

agcaccgtgc aggtctttac ggactcggag taccagttac cgtacgtgct aggatccgct     1920

caccagggat gtctgcctcc gttcccggcg gacgtcttca cggttcctca gtacggctat     1980

ttaactttaa acaatggaag ccaagccctg ggacgttcct ccttctactg tctggagtat     2040

ttcccatcgc agatgctgag aaccggcaac aactttcagt tcagctacac cttcgaggac     2100

gtgcctttcc acagcagcta cgcgcacagc cagagcctgg acaggctgat gaatcccctc     2160

atcgaccagt acctgtacta cctggtcaga acgcaaacga ctggaactgg agggacgcag     2220

actctggcat tcagccaagc gggtcctagc tcaatggcca accaggctag aaattgggtg     2280

cccggacctt gctaccggca gcagcgcgtc tccacgacaa ccaaccagaa caacaacagc     2340

aactttgcct ggacgggagc tgccaagttt aagctgaacg gccgagactc tctaatgaat     2400

ccgggcgtgg caatggcttc ccacaaggat gacgacgacc gcttcttccc ttcgagcggg     2460

gtcctgattt ttggcaagca aggagccggg aacgatggag tggattacag ccaagtgctg     2520

attacagatg aggaagaaat caaggctacc aaccccgtgg ccacagaaga atatggagca     2580

gtggccatca acaaccaggc cgccaatacg caggcgcaga ccggactcgt gcacaaccag     2640

ggggtgattc ccggcatggt gtggcagaat agagacgtgt acctgcaggg tcccatctgg     2700

gccaaaattc ctcacacgga cggcaacttt cacccgtctc ccctgatggg cggctttgga     2760

ctgaagcacc cgcctcctca aattctcatc aagaacacac cggttccagc ggacccgccg     2820

cttaccttca accaggccaa gctgaactct ttcatcacgc agtacagcac cggacaggtc     2880

agcgtggaaa tcgagtggga gctgcagaaa gaaaacagca aacgctggaa tccagagatt     2940

caatacactt ccaactacta caaatctaca aatgtggact ttgctgtcaa cacggaagga     3000

gtttatagcg agcctcgccc cattggcacc cgttacctca cccgcaacct gtaattacat     3060

gttaatcaat aaaccggtta attcgtttca gttgaacttt ggtctctgcg aagggcgaat     3120

tc                                                                    3122


<210> 4781
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 4781
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Leu Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Pro Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Thr Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Leu Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Val 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Thr Gly Gly Thr Gln Thr Leu Ala Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Ser Ser Met Ala Asn Gln Ala Arg Asn Trp Val Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Asn Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Ala Lys Phe Lys Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Met Asn Pro Gly Val Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Asp Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Ala Gly Asn Asp Gly Val Asp Tyr Ser Gln Val Leu Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ala Val Ala Ile Asn Asn Gln Ala Ala Asn Thr Gln Ala Gln 
            580                 585                 590         


Thr Gly Leu Val His Asn Gln Gly Val Ile Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Leu Thr Phe Asn Gln Ala Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 4782
<211> 3117
<212> DNA
<213> Adeno-associated virus

<400> 4782
gaattcgccc ttggctgcgt caactggacc aatgagaact ttcccttcaa cgattgcgtc       60

gacaagatgg tgatctggtg ggaggagggc aagatgacgg ccaaggtcgt ggagtccgcc      120

aaggccattc tcggcggcag caaggtgcgt gtggaccaaa agtgcaagtc ttccgcccag      180

atcgatccca cccccgtgat cgtcacctcc aacaccaaca tgtgcgccgt gattgacggg      240

aacagcacca ccttcgagca ccagcagccg ttgcaggacc ggatgttcaa atttgaactc      300

acccgccgtc tggagcatga ctttggcaag gtgacgaagc aggaagtcaa agagttcttc      360

cgctgggcgc aggatcacgt gaccgaggtg gcgcatgagt tccacgtcag aaagggtgga      420

gccaacaaga gacccgcccc cgatgacgcg gatataagcg agcccaagcg ggcctgcccc      480

tcagtcgcgg atccatcgac gtcagacgcg gaaggagctc cggtggactt tgccgacagg      540

taccaaaaca aatgttctcg tcacgcgggc atgcttcaga tgctgtttcc ctgcaagaca      600

tgcgagagaa tgaatcagaa tttcaacatt tgcttcacgc acgggaccag agactgttca      660

gaatgtttcc ccggcgtgtc agaatctcaa ccggtcgtca gaaagaggac gtatcggaaa      720

ctctgtgcga ttcatcatct gctggggcgg gctcccgaga ttgcttgctc ggcctgcgat      780

ctggtcaacg tggacctgga tgactgtgtt tctgagcaat aaatgactta aaccaggtat      840

ggctgccgat ggttatcttc cagattggct cgaggacaac ctctctgagg gcattcgcga      900

gtggtgggac ttgaaacctg gagccccgaa acccaaagcc aaccagcaaa agcaggacga      960

cggccggggt ctggtgcttc ctggctacaa gtacctcgga cccttcaacg gactcgacaa     1020

gggggagccc gtcaacgcgg cggacgcagc ggccctcgag cacgacaaag cctacgacca     1080

gcagctcaaa gcgggtgaca atccgtacct gcggtataat cacgccgacg ccgagtttca     1140

ggagcgtctg caagaagata cgtcttttgg gggcaacctc gggcgagcag tcttccaggc     1200

caagaagcgg gttctcgaac ctctcggtct ggttgaggaa ggcgctaaga cggctcctgg     1260

aaagaagaga ccggtagagc agtcgccaca agagccagac tcctcctcgg gcatcggcaa     1320

gacaggccag cagcccgcta aaaagagact caattttggt cagactggcg actcagagtc     1380

agtccccgac ccacaacctc tcggagaacc tccagcagcc ccctcaggtc tgggacctaa     1440

tacaatggct tcaggcggtg gcgctccaat ggcagacaat aacgaaggcg ccgacggagt     1500

gggtaattcc tcgggaaatt ggcattgcga ttccacatgg ctgggggaca gagtcatcac     1560

caccagcacc cgaacctggg ccctgcccac ctacaacaac cacctctaca agcaaatctc     1620

caacggcacc tcgggaggaa gcaccaacga caacacctat tttggctaca gcaccccctg     1680

ggggtatttt gacttcaaca gattccactg tcacttttca ccacgtgact ggcaacgact     1740

catcaacaac aattggggat tccggcccaa aagactcaac ttcaagctgt tcaacatcca     1800

ggtcaaggaa gtcacgacga acgaaggcac caagaccatc gccaataatc tcaccagcac     1860

cgtgcgggtc tttacggact cggagtacca gttaccgtac gtgctaggat ccgctcacca     1920

gggatgtctg cctccgttcc cggcggacgt cttcatggtt cctcagtacg gctatttaac     1980

tttaaacaat ggaagccaag ccctgggacg ttcctccttc tactgtctgg agtatttccc     2040

atcgcagatg ctgagaaccg gcaacaactt tcagttcagc tacaccttcg aggacgtgcc     2100

tttccacagc agctacgcgc acagccagag cctggacagg ctgatgaatc ccctcatcga     2160

ccagtacctg tactacctgg tcagaacgca aacgactgga actggaggga cgcagactct     2220

ggcattcagc caagcgggtc ctagctcaat ggccaaccag gctagaaatt gggtgcccgg     2280

accttgctac cggcagcagc gcgtctccac gacaaccaac cagagcaaca acagcaactt     2340

tgcctggacg ggagctgcca agtttaagct gaacggccga gactctctaa tgaatccggg     2400

cgtggcaatg gcttcccaca aggatgacga cgaccgcttc ttcccttcga gcggggtcct     2460

gatttttggc aagcaaggag ccgggaacga tggagtggat tacagccaag tgctgattac     2520

agatgaggaa gaaatcaagg ctaccaaccc cgtggccaca gaagaatatg gagcagtggc     2580

catcaacaac caggccgcca atacgcaggc gcagaccgga ctcgtgcaca accagggggt     2640

gattcccggc atggtgtggc agaatagaga cgtgtacctg cagggtccca tctgggccaa     2700

aattcctcac acggacggca actttcaccc gtctcccctg atgggcggct ttggactgaa     2760

gcacccgcct cctcaaattc tcatcaagaa cacaccggtt ccagcggacc cgccgcttac     2820

cttcaaccag gccaagctga actctttcat cacgcagtac agcaccggac aggtcagcgt     2880

ggaaatcgag tgggagctgc agaaagaaaa cagcaaacgc tggaatccag agattcaata     2940

cacttccaac tactacaaat ctacaaatgt ggactttgct gtcaacacgg aaggagttta     3000

tagcgagcct cgccccattg gcacccgtta cctcacccgc aacctgtaat tacatgttaa     3060

tcaataaacc ggttaattcg tttcagttga actttggtct ctgcgaaggg cgaattc        3117


<210> 4783
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 4783
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Pro Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Arg Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Leu Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Val 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Thr Gly Gly Thr Gln Thr Leu Ala Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Ser Ser Met Ala Asn Gln Ala Arg Asn Trp Val Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Asn Gln Ser 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Ala Lys Phe Lys Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Met Asn Pro Gly Val Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Asp Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Ala Gly Asn Asp Gly Val Asp Tyr Ser Gln Val Leu Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ala Val Ala Ile Asn Asn Gln Ala Ala Asn Thr Gln Ala Gln 
            580                 585                 590         


Thr Gly Leu Val His Asn Gln Gly Val Ile Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Leu Thr Phe Asn Gln Ala Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 4784
<211> 3121
<212> DNA
<213> Adeno-associated virus

<400> 4784
gaattcgccc ttctacggct gcgtcaactg gaccaatgag aactttccct tcaacgattg       60

cgtcgacaag atggtgatct ggtgggagga gggcaagatg acggccaagg tcgtggagtc      120

cgccaaggcc attctcggcg gcagcaaggt gcgtgtggac caaaagtgca agtcttccgc      180

ccagatcgat cccacccccg tgatcgtcac ctccaacacc aacatgtgcg ccgtgattga      240

cgggaacagc accaccttcg agcaccagca gccgttgcag gaccggatgt tcaaatttga      300

actcacccgc cgtctggagc atgactttgg caaggtgacg aagcaggaag tcaaagagtt      360

cttccgctgg gcgcaggatc acgtgaccga ggtggcgcat gagttccacg tcagaaaggg      420

tggcgccaac aagagacccg cccccgatga cgcggatata agcgagccca agcgggcctg      480

cccctcagtc gcggatccat cgacgtcaga cgcggaagga gctccggtgg actttgccga      540

caggtaccaa aacaaatgtt ctcgtcacgc gggcatgctt cagatgctgt ttccctgcaa      600

gacatgcgag agaatgaatc agaatttcaa catttgcttc acgcacggga ccagagactg      660

ttcagaatgt ttccccggcg tgtcagaatc tcaaccggtc gtcagaaaga ggacgtatcg      720

gaaactctgt gcgattcatc atctgctggg gcgggctccc gagattgctt gctcggcctg      780

cgatctggtc aacgtggacc tggatgactg tgtttctgag caataaatga cttaaaccag      840

gtatggctgc cgatggttat cttccagatt ggctcgagga caacctctct gagggcattc      900

gcgagtggtg ggacttgaaa cctggagccc cgaaacccaa agccaaccag caaaagcagg      960

acgacggccg gggtctggtg cttcctggct acaagtacct cggacccttc aacggactcg     1020

acaaggggga gcccgtcaac gcggcggacg cagcggccct cgagcacgac aaagcctacg     1080

accagcagct caaagcgggt gacaatccgt acctgcggta taatcacgcc gacgccgagt     1140

ttcaggagcg tctgcaagaa gatacgtcct ttgggggcaa cctcgggcga gcagtcttcc     1200

aggccaagaa gcgggttctc gaacctctcg gtctggttga ggaaggcgct aagacggctc     1260

ctggaaagaa gagaccggta gagcagtcgc cacaagagcc agactcctcc tcgggcatcg     1320

gcaagacagg ccagcagccc gctaaaaaga gactcaattt tggtcagact ggcgactcag     1380

agtcagtccc cgacccacaa cctctcggag aacctccagc agccccctca ggtctgggac     1440

ctaatacaat ggcttcaggc ggtggcgctc caatggcaga caataacgaa ggcgccgacg     1500

gagtgggtaa ttcctcggga aattggcatt gcgattccac atggctgggg gacagagtca     1560

tcaccaccag cacccgaacc tgggccctgc ccacctacaa caaccacctc tacaagcaaa     1620

tctccaacgg cacctcggga ggaagcacca acgacaacac ctattttggc tacagcaccc     1680

cctgggggta ttttgacttc aacagattcc actgtcactt ttcaccacgt gactggcaac     1740

gactcatcaa caacaattgg ggattccggc ccaaaagact caacttcaag ctgttcaaca     1800

tccaggtcaa ggaagtcacg acgaacgaag gcaccaagac catcgccaat aatctcacca     1860

gcaccgtgca ggtctttacg gacttggagt accagttacc gtacgtgcta ggatccgctc     1920

accagggatg tctgcctccg ttcccggcgg acgtcttcat ggttcctcag tacggctatt     1980

taactttaaa caatggaagc caagccctgg gacgttcctc cttctactgt ctggagtatt     2040

tcccatcgca gatgccgaga accggcaaca actttcagtt cagctacacc ttcgaggacg     2100

tgcctttcca cagcagctac gcgcacagcc agagcctgga caggctgatg aatcccctca     2160

tcgaccagta cctgtactac ctggtcagaa cgcaaacgac tggaactgga gggacgcaga     2220

ctctggcatt cagccaagcg ggtcctagct caatggccaa ccaggctaga aattgggtgc     2280

ccggaccttg ctaccggcag cagcgcgtct ccacgacaac caaccagaac aacaacagca     2340

actttgcctg gacgggagct gccaagttta agctgaacgg ccgagactct ctaatgaatc     2400

cgggcgtggc aatggcttcc cacaaggatg acgacgaccg cttcttccct tcgagcgggg     2460

tcctgatttt tggcaagcaa ggagccggga acgatggagt ggattacagc caagtgctga     2520

ttacagatga ggaagaaatc aaggctacca accccgtggc cacagaagaa tatggagcag     2580

tggccatcaa caaccaggcc gccaatacgc aggcgcagac cggactcgtg cacaaccagg     2640

gggtgattcc cggcatggtg tggcagaata gagacgtgta cctgcagggt cccatctggg     2700

ccaaaattcc tcacacggac ggcaactttc acccgtctcc cctgatgggc ggctttggac     2760

tgaagcaccc gcctcctcaa attctcatca agaacacacc ggttccagcg gacccgccgc     2820

ttaccttcaa ccaggccaag ctgaactctt tcatcacgca gtacagcacc ggacaggtca     2880

gcgtggaaat cgagtgggag ctgcagaaag aaaacagcaa acgctggaat ccagagattc     2940

aatacacttc caactactac aaatctacaa atgtggactt tgctgtcaac acggaaggag     3000

tttatagcga gcctcgcccc attggcaccc gttacctcac ccgcaacctg taattacatg     3060

ttaatcaata aaccggttaa ttcgtttcag ttgaactttg gtctctgcga agggcgaatt     3120

c                                                                     3121


<210> 4785
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 4785
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Pro Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Leu Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Leu Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Pro Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Val 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Thr Gly Gly Thr Gln Thr Leu Ala Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Ser Ser Met Ala Asn Gln Ala Arg Asn Trp Val Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Asn Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Ala Lys Phe Lys Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Met Asn Pro Gly Val Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Asp Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Ala Gly Asn Asp Gly Val Asp Tyr Ser Gln Val Leu Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ala Val Ala Ile Asn Asn Gln Ala Ala Asn Thr Gln Ala Gln 
            580                 585                 590         


Thr Gly Leu Val His Asn Gln Gly Val Ile Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Leu Thr Phe Asn Gln Ala Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 4786
<211> 3122
<212> DNA
<213> Adeno-associated virus

<400> 4786
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaagg tgcgtgtgga ccaaaagtgc aagtcttccg      180

cccagatcga tcccaccccc gtgatcgtca cctccaacac caacatgtgc gccgtgattg      240

acgggaacag caccaccttc gagcaccagc agccgttgca ggaccggatg ttcaaatttg      300

aactcacccg ccgtctggag catgactttg gcaaggtgac gaagcaggaa gtcaaagggt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca tgagttccac gtgcgagccc      420

aagcgggcct gcccctcagt cgcggatcca tcgacgtcag accagaaagg gtggagccaa      480

caagagaccc gcccccgatg acgcggatat aagcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg tttccctgca      600

agacatgcga gagaatgaat cagaatttca acatttgctt cacgcacggg accagagact      660

gttcagaatg tttccccggc gtgtcagaat ctcaaccggt cgtcagaaag aggacgtatc      720

ggaaactctg tgcgattcat catctgctgg ggcgggctcc cgagattgct tgctcggcct      780

gcgatctggt caacgtggac ctggatgact gtgtttctga gcaataaatg acttaaacca      840

ggtatggctg ccgatggtta tcttccagat tggctcgagg acaacctctc tgagggcatt      900

cgcgagtggt gggacttgaa acctggagcc ccgaaaccca aagccaacca gcaaaagcag      960

gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt caacggactc     1020

gacaaggggg agcccgtcaa cgcggcggac gcagcggccc tcgagcacga caaagcctac     1080

gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataatcacgc cgacgccgag     1140

tttcaggagc gtctgcaaga agatacgtct tttgggggca acctcgggcg agcagtcttc     1200

caggccaaga agcgggttct cgaacctctc ggtctggttg aggaaggcgc taagacggct     1260

cctggaaaga agagaccggt agagcagtcg ccacaagagc cagactcctc ctcgggcatc     1320

ggcaagacag gccagcagcc cgctaaaaag agactcaatt ttggtcagac tggcgactca     1380

gagtcagtcc ccgacccaca acctctcgga gaacctccag cagccccctc aggtctggga     1440

cctaatacaa tggcttcagg cggtggcgct ccaatggcag acaataacga aggcgccgac     1500

ggagtgggta attcctcggg aaattggcat tgcgattcca catggctggg ggacagagtc     1560

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa     1620

atctccaacg gcacctcggg aggaagcacc aacgacaaca cctattttgg ctacagcacc     1680

ccctgggggt attttgactt caacagattc cactgtcact tttcaccacg tgactggcaa     1740

cgactcatca acaacaattg gggattccgg cccaaaagac tcaacttcaa gctgttcaac     1800

atccaggtca aggaagtcac gacgaacgaa ggcaccaaga ccatcgccaa taatctcacc     1860

agcaccgtgc aggtctttac ggactcggag taccagttac cgtacgtgct aggatccgct     1920

caccagggat gtctgcctcc gttcccggcg gacgtcttca tggttcctca gtacggctat     1980

ttaactttaa acaatggaag ccaagccctg ggacgttcct ccttctactg tctggagtat     2040

ttcccatcgc agatgctgag aaccggcaac aactttcagt tcagctacac cttcgaggac     2100

gtgcctttcc acagcagcta cgcgcacagc cagagcctgg acaggctgat gaatcccctc     2160

atcgaccagt acctgtacta cctggtcaga acgcaaacga ctggaactgg agggacgcag     2220

actctggcat tcagccaagc gggtcctagc tcaatggcca accaggctag aaattgggtg     2280

cccggacctt gctaccggca gcagcgcgtc tccacgacaa ccaaccagaa caacaacagc     2340

aactttgcct ggacgggagc tgccaagttt aagctgaacg gccgagactc tctaatgaat     2400

ccgggcgtgg caatggcttc ccacaaggat gacgacgacc gcttcttccc ttcgagcggg     2460

gtcctgattt ttggcaagca aggagccggg aacgatggag tggattacag ccaagtgctg     2520

attacagatg aggaagaaat caaggctacc aaccccgtgg ccacagaaga atatggagca     2580

gtggccatca acaaccaggc cgccaatacg caggcgcaga ccggactcgt gcacaaccag     2640

ggggtgattc ccggcatggt gtggcagaat agagacgtgt acctgcaggg tcccatctgg     2700

gccaaaattc ctcacacgga cggcaacttt cacccgtctc ccctgatggg cggctttgga     2760

ctgaagcacc cgcctcctca aattctcatc aagaacacac cggttccagc ggacccgccg     2820

cttaccttca accaggccaa gctgaactct ttcatcacgc agtacagcac cggacaggtc     2880

agcgtggaaa tcgagtggga gctgcagaaa gaaaacagca aacgctggaa tccagagatt     2940

caatacactt ccaactacta caaatctaca aatgtggact ttgctgtcaa cacggagggg     3000

gtttatagcg agcctcgccc cattggcacc cgttacctca cccgcaacct gtaattacat     3060

gttaatcaat aaaccggtta attcgtttca gttgaacttt ggtctctgcg aagggcgaat     3120

tc                                                                    3122


<210> 4787
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 4787
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Pro Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Leu Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Val 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Thr Gly Gly Thr Gln Thr Leu Ala Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Ser Ser Met Ala Asn Gln Ala Arg Asn Trp Val Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Asn Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Ala Lys Phe Lys Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Met Asn Pro Gly Val Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Asp Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Ala Gly Asn Asp Gly Val Asp Tyr Ser Gln Val Leu Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ala Val Ala Ile Asn Asn Gln Ala Ala Asn Thr Gln Ala Gln 
            580                 585                 590         


Thr Gly Leu Val His Asn Gln Gly Val Ile Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Leu Thr Phe Asn Gln Ala Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 4788
<211> 2370
<212> DNA
<213> Adeno-associated virus

<400> 4788
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaagg tgcgcgtgga ccaaaagtgc aagtcgtccg      180

cccagatcga ccccaccccc gtgatcgtca cctccaacac caacatgtgc gccgtgattg      240

acgggaacag caccaccttc gagcaccagc agccgttgca ggaccggatg ttcaagttcg      300

aactcacccg ccgtctggag cacgactttg gcaaggtgac caagcaggaa gtcaaagagt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca tgagttctac gtcagaaagg      420

gcggagccag caaaagaccc gcccccgatg acgcggatat aagcgagccc aagcgggcct      480

gcccctcagt cgcggatcca tcgacgtcag acgcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagacgctg tttccctgca      600

aaacgtgcga gagaatgaat cagaatttca acatttgctt cacgcacggg gtcagagact      660

gctcagaatg tttccccggt gcatcagaat ctcaaccggt cgtcagaaaa aaaacgtatc      720

agaaactgtg tgccattcat catctgctgg ggcgggcacc cgagattgct tgctcggcct      780

gcgatctggt caacgtggac ctggacgact gtgtttctga gcaataaatg acttaaacca      840

ggtatggctg ccgatggtta tcttccagat tggcttgagg acaacctctc tgagggcatt      900

cgcgagtggt gggacctgaa acctggagcc ccgaaaccca aagccaacca gcaaaagcag      960

gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt caacggactc     1020

gacaaggggg agcccgtcaa cgcggcggac gcagcggccc tcgagcacga caaggcctac     1080

gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc cgacgccgag     1140

tttcaggagc gtctgcaaga agatacgtct tttgggggca acctcgggcg agcagtcttc     1200

caggccaaga agcgggttct cgaacctctc ggtctggttg aggaaggcgc taagacggct     1260

cctggaaaga agagaccggt agagccatca cctcagcgtt cccccgactc ctccacgggc     1320

atcggcaaga aaggccacca gcccgcgaga aagagactga actttgggca gactggcgac     1380

tcggagtcag tccccgaccc tcaaccaatc ggagaaccac cagcaggccc ctctggtctg     1440

ggatctggta caatggctgc aggcggtggc gctccaatgg cagacaataa cgaaggcgcc     1500

gacggagtgg gtagttcctc aggaaattgg cattgcgatt ccacatggct gggcgacaga     1560

gtcatcacca ccagcacccg aacctgggcc ctgcccacct acaacaacca tctctacaag     1620

caaatctcca acgggacatc gggaggaagc actaacgaca acacctactt tggctacagc     1680

accccctggg ggtattttga cttcaacaga ttccactgcc acttctcacc acgtgactgg     1740

cagcgactca tcaacaataa ctggggattc cggcccaaga gactcaactt caagctcttc     1800

aacatccagg tcaaggaggt cacgcagaat gaaggcacca agaccatcgc caataacctt     1860

accagcacga ttcaggtgtt tacggactcg gaataccagc tcccgtacgt cctcggctct     1920

gcgcaccagg gctgcctccc tccgttcccg gcggacgtct tcatgattcc tcagtacggg     1980

tatctgaccc taaacaatgg cagtcaggct gtgggccgtt cctccttcta ctgcctggaa     2040

tacttccctt ctcaaatgct gaggacgggc aacaactttg aattcagcta caccttcgag     2100

gacgtgcctt tccacagcag ctacgcgcac agccagagcc tggaccggct gatgaaccct     2160

ctcatcgacc agtacctgta ttacttatcc agaactcagt ccacaggagg aactcaaggt     2220

actcagcaat tgttattttc tcaagccggg cccgcaaaca tgtyggctca ggccaagaac     2280

tggctacctg gaccgtgtta ccgtcagcaa cgagtttcca cgacactgtc gcaaaacaac     2340

aacagcaatt ttgctggacc ggtgccacca                                      2370


<210> 4789
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4789
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly His Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Gly Ala 
            580                 585                 590         


Pro Ile Val Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Val Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4790
<211> 2205
<212> DNA
<213> Adeno-associated virus

<400> 4790
atgactgacg gttaccttcc agattggcta gaggacaacc tctctgaagg cgttcgagag       60

tggtgggcgc tgcaacctgg agcccctaaa cccaaggcaa atcaacaaca tcaggacaac      120

gctcggggtc ttgtgcttcc gggttacaaa tacctcggac ccggcaacgg actcgacaag      180

ggggaacccg tcaacgcagc ggacgcggca gccctcgagc acgacaaggc ctacgaccag      240

cagctcaagg ccggtgacaa cccctacctc aagtacaacc acgccgacgc ggagttccag      300

cagcggcttc agggcgacac atcgtttggg ggcaacctcg gcagagcagt cttccaggcc      360

aaaaagaggg ttcttgaacc tcttggtctg gttgagcaag cgggtgagac ggctcctgga      420

aagaagagac cgttgattga atccccccag cagcccgact cctccacggg tatcggcaaa      480

aaaggcaagc agccggctaa aaagaagctc gttttcgaag acgaaactgg agcaggcgac      540

ggaccccctg agggatcaac ttccggagcc atgtctgatg acagtgagat gcgtgcagca      600

gctggcggag ctgcagtcga gggcggacaa ggtgccgatg gagtgggtaa tgcctcgggt      660

gattggcatt gcgattccac ctggtctgag ggccacgtca cgaccaccag caccagaacc      720

tgggtcttgc ccacctacaa caaccacctc tacaagcgac tcggagagag cctgcagtcc      780

aacacctaca acggattctc caccccctgg ggatactttg acttcaaccg cttccactgc      840

cacttctcac cacgtgactg gcagcgactc atcaacaaca actggggcat gcgacccaaa      900

gccatgcggg tcaaaatctt caacatccag gtcaaggagg tcacgacgtc gaacggcgag      960

acaacggtgg ctaataacct taccagcacg gttcagatct ttgcggactc gtcgtacgaa     1020

ctgccgtacg tgatggatgc gggtcaagag ggcagcctgc ctccttttcc caacgacgtc     1080

tttatggtgc cccagtacgg ctactgtgga ctggtgaccg gcaacacttc gcagcaacag     1140

actgacagaa atgccttcta ctgcctggag tactttcctt cgcagatgct gcggactggc     1200

aacaactttg aaattacgta cagttttgag aaggtgcctt tccactcgat gtacgcgcac     1260

agccagagcc tggaccggct gatgaaccct ctcatcgacc agtacctgtg gggactgcaa     1320

tcgaccacca ccggaaccac cctgaatgcc gggactgcca ccaccaactt taccaagctg     1380

cggcctacca acttttccaa ctttaaaaag aactggctgc ccgggccttc aatcaagcag     1440

cagggcttct caaagactgc caatcaaaac tacaagatcc ctgccaccgg gtcagacagt     1500

ctcatcaaat acgagacgca cagcactctg gacggaagat ggagtgccct gacccccgga     1560

cctccaatgg ccacggctgg acctgcggac agcaagttca gcaacagcca gctcatcttt     1620

gcggggccta aacagaacgg caacacggcc accgtacccg ggactctgat cttcacctct     1680

gaggaggagc tggcagccac caacgccacc gatacggaca tgtggggcaa cctacctggc     1740

ggtgaccaga gcaacagcaa cctgccgacc gtggacagac tgacagcctt gggagccgtg     1800

cctggaatgg tctggcaaaa cagagacatt tactaccagg gtcccatttg ggccaagatt     1860

cctcataccg atggacactt tcacccctca ccgctgattg gtgggtttgg gctgaaacac     1920

ccgcctcctc aaatttttat caagaacacc ccggtacctg cgaatcctgc aacgaccttc     1980

agctctactc cggtaaactc cttcattact cagtacagca ctggccaggt gtcggtgcag     2040

attgactggg agatccagaa ggagcggtcc aaacgctgga accccgaggt ccagtttacc     2100

tccaactacg gacagcaaaa ctctctgttg tgggctcccg atgcggctgg gaaatacact     2160

gagcctaggg ctatcggtac ccgctacctc acccaccacc tgtaa                     2205


<210> 4791
<211> 734
<212> PRT
<213> Adeno-associated virus

<400> 4791
Met Thr Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser Glu 
1               5                   10                  15      


Gly Val Arg Glu Trp Trp Ala Leu Gln Pro Gly Ala Pro Lys Pro Lys 
            20                  25                  30          


Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro Val 
    50                  55                  60                  


Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp Gln 
65                  70                  75                  80  


Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Gln Arg Leu Gln Gly Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Leu 
        115                 120                 125             


Gly Leu Val Glu Gln Ala Gly Glu Thr Ala Pro Gly Lys Lys Arg Pro 
    130                 135                 140                 


Leu Ile Glu Ser Pro Gln Gln Pro Asp Ser Ser Thr Gly Ile Gly Lys 
145                 150                 155                 160 


Lys Gly Lys Gln Pro Ala Lys Lys Lys Leu Val Phe Glu Asp Glu Thr 
                165                 170                 175     


Gly Ala Gly Asp Gly Pro Pro Glu Gly Ser Thr Ser Gly Ala Met Ser 
            180                 185                 190         


Asp Asp Ser Glu Met Arg Ala Ala Ala Gly Gly Ala Ala Val Glu Gly 
        195                 200                 205             


Gly Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys 
    210                 215                 220                 


Asp Ser Thr Trp Ser Glu Gly His Val Thr Thr Thr Ser Thr Arg Thr 
225                 230                 235                 240 


Trp Val Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Arg Leu Gly Glu 
                245                 250                 255     


Ser Leu Gln Ser Asn Thr Tyr Asn Gly Phe Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Asn Trp Gly Met Arg Pro Lys Ala Met Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Thr Ser Asn Gly Glu 
305                 310                 315                 320 


Thr Thr Val Ala Asn Asn Leu Thr Ser Thr Val Gln Ile Phe Ala Asp 
                325                 330                 335     


Ser Ser Tyr Glu Leu Pro Tyr Val Met Asp Ala Gly Gln Glu Gly Ser 
            340                 345                 350         


Leu Pro Pro Phe Pro Asn Asp Val Phe Met Val Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Cys Gly Leu Val Thr Gly Asn Thr Ser Gln Gln Gln Thr Asp Arg Asn 
    370                 375                 380                 


Ala Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly 
385                 390                 395                 400 


Asn Asn Phe Glu Ile Thr Tyr Ser Phe Glu Lys Val Pro Phe His Ser 
                405                 410                 415     


Met Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile 
            420                 425                 430         


Asp Gln Tyr Leu Trp Gly Leu Gln Ser Thr Thr Thr Gly Thr Thr Leu 
        435                 440                 445             


Asn Ala Gly Thr Ala Thr Thr Asn Phe Thr Lys Leu Arg Pro Thr Asn 
    450                 455                 460                 


Phe Ser Asn Phe Lys Lys Asn Trp Leu Pro Gly Pro Ser Ile Lys Gln 
465                 470                 475                 480 


Gln Gly Phe Ser Lys Thr Ala Asn Gln Asn Tyr Lys Ile Pro Ala Thr 
                485                 490                 495     


Gly Ser Asp Ser Leu Ile Lys Tyr Glu Thr His Ser Thr Leu Asp Gly 
            500                 505                 510         


Arg Trp Ser Ala Leu Thr Pro Gly Pro Pro Met Ala Thr Ala Gly Pro 
        515                 520                 525             


Ala Asp Ser Lys Phe Ser Asn Ser Gln Leu Ile Phe Ala Gly Pro Lys 
    530                 535                 540                 


Gln Asn Gly Asn Thr Ala Thr Val Pro Gly Thr Leu Ile Phe Thr Ser 
545                 550                 555                 560 


Glu Glu Glu Leu Ala Ala Thr Asn Ala Thr Asp Thr Asp Met Trp Gly 
                565                 570                 575     


Asn Leu Pro Gly Gly Asp Gln Ser Asn Ser Asn Leu Pro Thr Val Asp 
            580                 585                 590         


Arg Leu Thr Ala Leu Gly Ala Val Pro Gly Met Val Trp Gln Asn Arg 
        595                 600                 605             


Asp Ile Tyr Tyr Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp 
    610                 615                 620                 


Gly His Phe His Pro Ser Pro Leu Ile Gly Gly Phe Gly Leu Lys His 
625                 630                 635                 640 


Pro Pro Pro Gln Ile Phe Ile Lys Asn Thr Pro Val Pro Ala Asn Pro 
                645                 650                 655     


Ala Thr Thr Phe Ser Ser Thr Pro Val Asn Ser Phe Ile Thr Gln Tyr 
            660                 665                 670         


Ser Thr Gly Gln Val Ser Val Gln Ile Asp Trp Glu Ile Gln Lys Glu 
        675                 680                 685             


Arg Ser Lys Arg Trp Asn Pro Glu Val Gln Phe Thr Ser Asn Tyr Gly 
    690                 695                 700                 


Gln Gln Asn Ser Leu Leu Trp Ala Pro Asp Ala Ala Gly Lys Tyr Thr 
705                 710                 715                 720 


Glu Pro Arg Ala Ile Gly Thr Arg Tyr Leu Thr His His Leu 
                725                 730                 


<210> 4792
<211> 3128
<212> DNA
<213> Adeno-associated virus

<400> 4792
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatgttgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaaag tgcgcgtgga ccaaaagtgc aagccgtccg      180

cccagatcga ccccaccccc gtgatcgtca cctccaacac caacatgtgc gccgtgattg      240

acgggaacag caccaccttc gagcaccagc agccgttgcg ggaccggatg ttcaagtttg      300

aactcacccg ccgtctggag cacgactttg gcaaggtgac aaagcaggaa gtcagagagt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca cgagttctac gtcagaaagg      420

gtggagccaa caagagaccc gcccccgatg acgcggataa aagcgagccc aagcgggcct      480

gcccctcagt cgcggatcca tcgacgtcag acgcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg tttccctgca      600

aaacatgcga gagaatgaat cagaatttca acatttgctt cacgcacggg accagagact      660

gttcagaatg tttccccggc gtgtcagaat ctcaaccggt cgtcagaaaa aagacgtatc      720

ggaaactctg tgcgattcat catctgctgg ggcgggcacc cgagattgct tgctcggcct      780

gcgatctggt caacgtggac ctagatgact gtgtttctga gcaataaatg acttaaacca      840

ggtatggctg ccgatggtta tcttccagat tggctcgagg acaacctctc tgagggcatt      900

cgcgagtggt gggacttgaa acctggagcc ccgaaaccca aagccaacca gcaaaagcag      960

gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt caacggactc     1020

gacaaggggg agcccgtcaa cgcggcggac gcagcggccc tcgagcacga caaggcctac     1080

gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc cgacgccgag     1140

tttcaggagc gtctgcaaga agatacgtct tttgggggca acctcgggcg agcagtcttc     1200

caggccaaga agcgggttct cgaacctctc ggtctggttg aggaaggcgc taagacggct     1260

cctggaaaga agagaccggt agagccatca ccccagcgtt ctccagactc ctctacgggc     1320

atcggcaaga aaggccagca gcccgcgaaa aagagactca actttgggca gactggcgac     1380

tcagagtcag tgcccgaccc tcaaccaatc ggagaacccc ccgcaggccc ctctggtctg     1440

ggatctggta caatggctgc aggcggtggc gctccaatgg cagacaataa cgaaggcgcc     1500

gacggagtgg gtagttcctc aggaaattgg cattgcgatt ccacatggct gggcgacaga     1560

gtcatcacca ccagcacccg aacctgggcc ctccccacct acaacaacca cctctacaag     1620

caaatctcca acgggacttc gggaggaagc accaacgaca acacctactt cggctacagc     1680

accccctggg ggtattttga ctttaacaga ttccactgcc acttctcacc acgtgactgg     1740

cagcgactca tcaacaacaa ctggggattc cggcccaaga gactcaactt caagctcttc     1800

aacatccagg tcaaggaggt cacgcagaat gaaggcacca agaccatcgc caataacctt     1860

accagcacga ttcaggtctt tacggactcg gaataccagc tcccgtacgt cctcggctct     1920

gcgcaccagg gctgcctgcc tccgttcccg gcggacgtct tcatgattcc tcagtacggg     1980

tacctgactc tgaacaatgg cagtcaggcc gtgggccgtt cctccttcta ctgcctggag     2040

tactttcctt ctcaaatgct gagaacgggc aacaactttg agttcagcta ccagtttgag     2100

gacgtgcctt ttcacagcag ctacgcgcac agccaaagcc tggaccggct gatgaacccc     2160

ctcatcgacc agtacctgta ctacctgtct cggactcagt ccacgggagg taccgcagga     2220

actcagcagt tgctattttc tcaggccggg cctaataaca tgtcggctca ggccaaaaac     2280

tggctacccg ggccctgcta ccggcagcaa cgcgtctcca cgacactgtc gcaaaataac     2340

aacagcaact gtaaatcccg gtgtcgctat ggcaacccac aaggacgacg aagagcgatt     2400

ttgcctggac cggtgccacc aagtatcatc tgaatggcag agactctctg ttttccgtcc     2460

agcggagtct taatgtttgg gaaacaggga gctggaaaag acaacgtgga ctatagcagc     2520

gttatgctaa ccagtgagga agaaattaaa accaccaacc cagtggccac ggaacagtac     2580

ggcgtggtgg ccgataacct gcaacagcaa aacgccgctc ctattgtagg ggccgtcaac     2640

agtcaaggag ccttacctgg catggtctgg cagaaccggg acgtgtacct gcagggtcct     2700

atctgggcca agattcctca cacggacgga aactttcatc cctcgccgct gatgggaggc     2760

tttggactga aacacccgcc tcctcagatc ctgattaaga atacacctgt tcccgcggat     2820

cctccaacta ccttcagtca agctaagctg gcgtcgttca tcacgcagta cagcaccgga     2880

caggtcagcg tggaaattga atgggagctg cagaaagaaa acagcaaacg ctggaaccca     2940

gagattcaat acacttccaa ctactacaaa tctacaaatg tggacttcgc tgttaacaca     3000

gatggcactt attctgagcc tcgccccatt ggcacccgtt acctcacccg taatctgtaa     3060

ttgctcgtta atcaataaac cggttgattc gtttcagttg aactttggtc tctgcgaagg     3120

gcgaattc                                                              3128


<210> 4793
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4793
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Asp 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4794
<211> 3129
<212> DNA
<213> Adeno-associated virus

<400> 4794
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaaag tgcgcgtgga ccaaaagtgc aagtcgtccg      180

cccagatcga ccccaccccc gtgatcgtca cctccaacac caacatgtgc gccgtgattg      240

acgggaacag caccaccttc gagcaccagc agccgttgca ggaccggatg ttcaagtttg      300

aactcacccg ccgtctggag cacgactttg gcaaggtgac aaagcaggaa gtcagagagt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca cgagttctac gtcagaaagg      420

gtggagccaa caagagaccc gcccccgatg acgcggataa aagcgagccc aagcgggcct      480

gcccctcagt cgcggatcca tcgacgtcag acgcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg tttccctgca      600

aaacatgcga gagaatgaat cagaatttca acatttgctt cacgcacggg accagagact      660

gttcagaatg tttccccggc gtgtcagaat ctcaaccggt cgtcagaaaa aagacgtatc      720

ggaaactctg tgcgattcat catctgctgg gggcgggcac ccgagattgc ttgctcggcc      780

tgcgatctgg tcaacgtgga cctagatgac tgtgtttctg agcaataaat gacttaaacc      840

aggtatggct gccgatggtt atcttccaga ttggctcgag gacaacctct ctgagggcat      900

tcgcgagtgg tgggacttga aacctggagc cccgaaaccc aaagccaacc agcaaaagca      960

ggacgacggc cggggtctgg tgcttcctgg ctacaagtac ctcggaccct tcaacggact     1020

cgacaagggg gagcccgtca acgcggcgga cgcagcggcc ctcgagcacg acaaggccta     1080

cgaccagcag ctcaaagcgg gtgacaatcc gtacctgcgg tataaccacg ccgacgccga     1140

gtttcaggag cgtctgcaag aagatacgtc ttttgggggc aacctcgggc gagcagtctt     1200

ccaggccaag aagcgggttc tcgaacctct cggtctggtt gaggaaggcg ctaagacggc     1260

tcctggaaag aagagaccgg tagagccatc accccagcgt tctccagact cctctacggg     1320

catcggcaag aaaggccagc agcccgcgaa aaagagactc aactttgggc agactggcga     1380

ctcagagtca gtgcccgacc ctcaaccaat cggagaaccc cccgcaggcc cctctggtct     1440

gggatctggt acaatggctg caggcggtgg cgctccaatg gcagacaata acgaaggcgc     1500

cgacggagtg ggtagttcct caggaaattg gcattgcgat tccacatggc tgggcgacag     1560

agtcatcacc accagcaccc gaacctgggc cctccccacc tacaacaacc acctctacaa     1620

gcaaatctcc aacgggactt cgggaggaag caccaacgac aacacctact tcggctacag     1680

caccccctgg gggtattttg actttaacag attccactgc cacttctcac cacgtgactg     1740

gcagcgactc atcaacaaca actggggatt ccggcccaag agactcaact tcaagctctt     1800

caacatccag gtcaaggagg tcacgcagaa tgaaggcacc aagaccatcg ccaataacct     1860

taccagcacg attcaggtct ttacggactc ggaataccag ctcccgtacg tcctcggctc     1920

tgcgcaccag ggctgcctgc ctccgttccc ggcggacgtc ttcatgattc ctcagtacgg     1980

gtacctgact ctgaacaatg gcagtcaggc cgtgggccgt tcctccttct actgcctgga     2040

gtactttcct tctcaaatgc tgagaacggg caacaacttt gagttcagct accagtttga     2100

ggacgtgcct tttcacagca gctacgcgca cagccaaagc ctggaccggc tgatgaaccc     2160

cctcatcgac cagtacctgt actacctgtc tcggactcag tccacgggag gtaccgcagg     2220

aactcagcag ttgctatttt ctcaggccgg gcctaataac atgtcggctc aggccaaaaa     2280

ctggctaccc gggccctgct accggcagca acgcgtctcc acgacactgt cgcaaaataa     2340

caacagcaac tttgcctgga ccggtgccac caagtatcat ctgaatggca gagactctct     2400

ggtaaatccc ggtgtcgcta tggcaaccca caaggacgac gaagagcgat tttttccgtc     2460

cagcggagtc ttaatgtttg ggaaacaggg agctggaaaa gacaacgtgg actatagcag     2520

cgttatgcta accagtgagg aagaaattaa aaccaccaac ccagtggcca cagaacagta     2580

cggcgtggtg gccgataacc tgcaacagca aaacgccgct cctattgtag gggccgtcaa     2640

cagtcaagga gccttacctg gcatggtctg gcagaaccgg gacgtgtacc tgcagggtcc     2700

tatctgggcc aagattcctc acacggacgg aaactttcat ccctcgccgc tgatgggagg     2760

ctttggactg aaacacccgc ctcctcagat cctgattaag aatacacctg ttcccgcgga     2820

tcctccaact accttcagtc aagctaagct ggcgtcgttc atcacgcagt acagcaccgg     2880

acaggtcagc gtggaaattg aatgggagct gcagaaagaa aacagcaaac gctggaaccc     2940

agagattcaa tacacttcca actactacaa atctacaaat gtggactttg ctgttaacac     3000

agatggcact tattctgagc ctcgccccat cggcacccgt tacctcaccc gtaatctgta     3060

attgcttgtt aatcaataaa ccggttgatt cgtttcagtt gaactttggt ctctgcgaag     3120

ggcgaattc                                                             3129


<210> 4795
<211> 3128
<212> DNA
<213> Adeno-associated virus

<400> 4795
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaaag tgcgcgtgga ccaaaagtgc aagtcgtccg      180

cccagatcga ccccaccccc gtgatcgtca cctccaacac caacatgtgc gccgtgattg      240

acgggaacag caccaccttc gagcaccagc agccgttgca ggaccggatg ttcaagtttg      300

aactcacccg ccgtctggag cacgactttg gcaaggtgac aaagcaggaa gtcagagagt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca cgagttctac gtcagaaagg      420

gtggagccaa caagagaccc gcccccgatg acgcggataa aagcgagccc aagcgggcct      480

gcccctcagt cgcggatcca tcgacgtcag acgcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg tttccctgca      600

aaacatgcga gagaatgaat cagaatttca acatttgctt cacgcacggg accagagact      660

gttcagaatg tttccccggc gtgtcagaat ctcaaccggt tgtcagaaaa aagacgtatc      720

ggaaactctg tgcgattcat catctgctgg ggcgggcacc cgagattgct tgctcggcct      780

gcgatctggt caacgtggac ctagatgact gtgtttctga gcaataaatg acttaaacca      840

ggtatggctg ccgatggtta tcttccagat tggctcgagg acaacctctc tgagggcatt      900

cgcgagtggt gggacttgaa acctggagcc ccgaaaccca aagccaacca gcaaaagcag      960

gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt caacggactc     1020

gacaaggggg agcccgtcaa cgcggcggac gcagcggccc tcgagcacga caaggcctac     1080

gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc cgacgccgag     1140

tttcaggagc gtctgcaaga agatacgtct tttgggggca acctcgggcg agcagtcttc     1200

caggccaaga agcgggttct cgaacctctc ggtctggttg aggaaggcgc taagacggct     1260

cctggaaaga agagaccggt agagccatca ccccagcgtt ctccagactc ctctacgggc     1320

atcggcaaga aaggccagca gcccgcgaaa aagagactca actttgggca gactggcgac     1380

tcagagtcag tgcccgaccc tcaaccaatc ggagaacccc ccgcaggccc ctctggtctg     1440

ggatctggta caatggctgc aggcggtggc gctccaatgg cagacaataa cgaaggcgcc     1500

gacggagtgg gtagttcctc aggaaattgg cattgcgatt ccacatggct gggcgacaga     1560

gtcatcacca ccagcacccg aacctgggcc ctccccacct acaacaacca cctctacaag     1620

caaatctcca acgggacttc gggaggaagc accaacgaca acacctactt cggctacagc     1680

accccctggg ggtattttga ctttaacaga ttccactgcc acttctcacc acgtgactgg     1740

cagcgactca tcaacaacaa ctggggattc cggcccaaga gacccaactt caagctcttc     1800

aacatccagg tcaaggaggt cacgcagaat gaaggcacca agaccatcgc caataacctt     1860

accagcacga ttcaggtctt tacggactcg gaataccagc tcccgtacgt cctcggctct     1920

gcgcaccagg gctgcctgcc tccgttcccg gcggacgtct tcatgattcc tcagtacggg     1980

tacctgactc tgaacaatgg cagtcaggcc gtgggccgtt cctccttcta ctgcctggag     2040

tactttcctt ctcaaatgct gagaacgggc aacaactttg agttcagcta ccagtttgag     2100

gacgtgcctt ttcacagcag ctacgcgcac agccaaagcc tggaccggct gatgaacccc     2160

ctcatcgacc agtacctgta ctacctgtct cggactcagt ccacgggagg taccgcagga     2220

actcagcagt tgctattttc tcaggccggg cctaataaca tgtcggctca ggccaaaaac     2280

tggctacccg ggccctgcta ccggcagcaa cgcgtctcca cgacactgtc gcaaaataac     2340

aacagcaact ttgcctggac cggtgccacc aagtatcatc tgaatggcag agactctctg     2400

gtaaatcccg gtgtcgctat ggcaacccac aaggacgacg aagagcgatt ttttccgtcc     2460

agcggagtct taatgtttgg gaaacaggga gctggaaaag acaacgtgga ctatagcagc     2520

gttatgctaa ccagtgagga agaaattaaa accaccaacc cagtggccac agaacagtac     2580

ggcgtggtgg ccgataacct gcaacagcaa aacgccgctc ctattgtagg ggccgtcaac     2640

agtcaaggag ccttacctgg catggtctgg cagaaccggg acgtgtacct gcagggtcct     2700

atctgggcca agattcctca cacggacgga aactttcatc cctcgccgct gatgggaggc     2760

tttggactga aacacccgcc tcctcagatc ctgattaaga atacacctgt tcccgcggat     2820

cctccaacta ccttcagtca agctaagctg gcgtcgttca tcacgcagta cagcaccgga     2880

caggtcagcg tggaaattga atgggagctg cagaaagaaa acagcaaacg ctggaaccca     2940

gagattcaat acacttccaa ctactacaaa tctacaaatg tggactttgc tgttaacaca     3000

gatggcactt attctgagcc tcgccccatt ggcacccgtt acctcacccg taatctgtaa     3060

ttgcttgtta atcaataaac cggttgattc gtttcagttg aactttggtc tctgcgaagg     3120

gcgaattc                                                              3128


<210> 4796
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4796
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Pro Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Asp 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4797
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4797
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4798
<211> 720
<212> PRT
<213> Adeno-associated virus

<400> 4798
Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 
    130                 135                 140                 


Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 
145                 150                 155                 160 


Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 
                165                 170                 175     


Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 
            180                 185                 190         


Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 
        195                 200                 205             


Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 
    210                 215                 220                 


Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 
225                 230                 235                 240 


Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 
                245                 250                 255     


Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 
305                 310                 315                 320 


Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 
                325                 330                 335     


Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 
            340                 345                 350         


Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 
    370                 375                 380                 


Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 
                405                 410                 415     


Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 
            420                 425                 430         


Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 
        435                 440                 445             


Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 
    450                 455                 460                 


Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 
465                 470                 475                 480 


Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 
                485                 490                 495     


Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 
            500                 505                 510         


Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 
        515                 520                 525             


Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 
    530                 535                 540                 


Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 
545                 550                 555                 560 


Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser Ser 
                565                 570                 575     


Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val Pro 
            580                 585                 590         


Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 
        595                 600                 605             


Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala Met 
    610                 615                 620                 


Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys Asn 
625                 630                 635                 640 


Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro Val Ser 
                645                 650                 655     


Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu 
            660                 665                 670         


Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln 
        675                 680                 685             


Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp 
    690                 695                 700                 


Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu 
705                 710                 715                 720 


<210> 4799
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 4799
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 4800
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 4800
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 4801
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 4801
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 4802
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 4802
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 4803
<211> 728
<212> PRT
<213> Adeno-associated virus

<400> 4803
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Gly Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Arg Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Asn Gly Gln 
145                 150                 155                 160 


Pro Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asp Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210> 4804
<211> 2211
<212> DNA
<213> Adeno-associated virus

<400> 4804
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctccgc gggtattggc      480

aaatcgggtg cacagcccgc taaaaagaga ctcaatttcg gtcagactgg cgacacagag      540

tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca gtggcagaca ataacgaagg tgccgatgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgccacttct caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggcct aagcgactca acttcaagct cttcaacatt      960

caggtcaaag aggttacgga caacaatgga gtcaagacca tcgccaataa ccttaccagc     1020

acggtccagg tcttcacgga ctcagactat cagctcccgt acgtgctcgg gtcggctcac     1080

gagggctgcc tcccgccgtt cccagcggac gttttcatga ttcctcagta cgggtatctg     1140

acgcttaatg atggaagcca ggccgtgggt cgttcgtcct tttactgcct ggaatatttc     1200

ccgtcgcaaa tgctaagaac gggtaacaac ttccagttca gctacgagtt tgagaacgta     1260

cctttccata gcagctacgc tcacagccaa agcctggacc gactaatgaa tccactcatc     1320

gaccaatact tgtactatct ctcaaagact attaacggtt ctggacagaa tcaacaaacg     1380

ctaaaattca gtgtggccgg acccagcaac atggctgtcc agggaagaaa ctacatacct     1440

ggacccagct accgacaaca acgtgtctca accactgtga ctcaaaacaa caacagcgaa     1500

tttgcttggc ctggagcttc ttcttgggct ctcaatggac gtaatagctt gatgaatcct     1560

ggacctgcta tggccagcca caaagaagga gaggaccgtt tctttccttt gtctggatct     1620

ttaatttttg gcaaacaagg aactggaaga gacaacgtgg atgcggacaa agtcatgata     1680

accaacgaag aagaaattaa aactactaac ccggtagcaa cggagtccta tggacaagtg     1740

gccacaaacc accagagtgc ccaagcacag gcgcagaccg gctgggttca aaaccaagga     1800

atacttccgg gtatggtttg gcaggacaga gatgtgtacc tgcaaggacc catttgggcc     1860

aaaattcctc acacggacgg caactttcac ccttctccgc tgatgggagg gtttggaatg     1920

aagcacccgc ctcctcagat cctcatcaaa aacacacctg tacctgcgga tcctccaacg     1980

gccttcaaca aggacaagct gaactctttc atcacccagt attctactgg ccaagtcagc     2040

gtggagatcg agtgggagct gcagaaggaa aacagcaagc gctggaaccc ggagatccag     2100

tacacttcca actattacaa gtctaataat gttgaatttg ctgttaatac tgaaggtgta     2160

tatagtgaac cccgccccat tggcaccaga tacctgactc gtaatctgta a              2211


<210> 4805
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 4805
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 4806
<211> 2460
<212> DNA
<213> Adeno-associated virus

<400> 4806
ggtaattcct ccggaaattg gcattgcgat tccacatggc tgggcgaccg agtcattacc       60

accagcaccc ggacttgggc cctgcccacc tacaacaacc acctctacaa gcaaatctcc      120

agccaatcgg gtgccaccaa cgacaaccac tacttcggct acagcacccc ttgggggtat      180

tttgatttca acagattcca ctgccatttc tcaccacgtg actggcagcg actcatcaac      240

aacaactggg gattcatggc tgccgatggt tatcttccag attggctcga ggacactctc      300

tctgaaggaa tcagacagtg gtggaagctc aaacctggcc caccaccgcc gaaacctaac      360

caacaacacc gggacgacag taggggtctt gtgcttcctg ggtacaagta cctcggaccc      420

ttcaacggac tcgacaaagg agagccggtc aacgaggcag acgccgcggc cctcgagcac      480

gacaaagcct acgaccacca gctcaagcaa ggggacaacc cgtacctcaa atacaaccac      540

gcggacgctg aatttcagga gcgtcttcaa gaagatacgt ctttcggggg caacctcggg      600

cgagcagtct tccaggccaa aaagagggta ctcgagcctc ttggtctggt tgaggaagct      660

gttaagacgg ctcctggaaa aaagagacct atagagcagt ctcctgcaga accggactct      720

tcctcgggca tcggcaaatc aggccagcag cccgctaaga aaagactcaa ttttggtcag      780

actggcgaca cagagtcagt cccagaccct caaccaatcg gagaaccccc cgcagccccc      840

tctggtgtgg gatctaatac aatggcttca ggcggtgggg caccaatggc agacaataac      900

gaaggcgccg acggagtggg taattcctcg ggaaattggc attgcgattc cacatggatg      960

ggcgacagag ttatcaccac cagcacaaga acctgggccc tccccaccta caataatcac     1020

ctctacaagc aaatctccag cgaatcggga gccaccaacg acaaccacta cttcggctac     1080

agcaccccct gggggtattt tgactttaac agattccact gtcacttctc accacgtgac     1140

tggcagcgac tcatcaacaa caactgggga tttagaccca agaaactcaa tttcaagctc     1200

ttcaacatcc aagtcaagga ggtcacgcag aatgatggaa ccacgaccat cgccaataac     1260

cttaccagca cggtgcaggt cttcacagac tctgagtacc agctgcccta cgtcctcggt     1320

tcggctcacc agggctgcct tccgccgttc ccagcagacg tcttcatgat tcctcagtac     1380

ggctacttga ctctgaacaa tggcagccaa gcggtaggac gttcttcatt ctactgtcta     1440

gagtattttc cctctcagat gctgaggacg ggaaacaact tcaccttcag ctacactttt     1500

gaagacgtgc ctttccacag cagctacgcg cacagccaga gtctggatcg gctgatgaat     1560

cctctcattg accagtacct gtattacctg agcaaaactc agggtacaag tggaacaacg     1620

cagcaatcga gactgcagtt cagccaagct gggcctagct ccatggctca gcaggccaaa     1680

aactggctac cgggacccag ctaccgacag cagcgaatgt ctaagacggc taatgacaac     1740

aacaacagtg aatttgcttg gactgcagcc accaaatatt acctgaatgg aagaaattct     1800

ctggtcaatc ccgggccccc aatggccagt cacaaggacg atgaggaaaa gtatttcccc     1860

atgcacggaa atctcatctt tggaaaacaa ggcacaggaa ctaccaatgt ggacattgaa     1920

tcagtgctta ttacagacga agaagaaatc agaacaacta atcctgtggc tacagaacaa     1980

tacggacagg ttgccaccaa ccatcagagt cagaacacca cagcttccta tggaagtgtg     2040

gacagccagg gaatcttacc tggaatggtg tggcaggacc gcgatgtcta tcttcaaggt     2100

cccatttggg ccaaaactcc tcacacggac ggacactttc atccttctcc gctcatggga     2160

ggctttggac tgaaacaccc tcctccccag atcctgatca aaaacacacc tgtgccagcg     2220

aatcccgcga ccactttcac tcctggaaag tttgcttcgt tcattaccca gtattccacc     2280

ggacaggtca gcgtggaaat agagtgggag ctgcagaaag aaaacagcaa acgctggaac     2340

ccagaaattc agtacacctc caactacaac aagtcggtga atgtggagtt taccgtggac     2400

gcaaacggtg tttattctga accccgccct attggcactc gttaccttac ccggaacttg     2460


<210> 4807
<211> 3123
<212> DNA
<213> Adeno-associated virus

<400> 4807
gaattcgccc tttctacggc tgcgtcaact ggaccaatga aaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggaaagat gaccgccaag gtcgtggaat      120

ctgccaaagc cattctgggt ggaggcaagg ttcgtgtgga ccagaaatgc aagtcttcgg      180

cccagatcga cccgactccg gtgattgtca cctctaacac caacatgtgc gccgtgattg      240

acggaaactc gaccaccttc gagcaccagc agccgttgca agaccggatg ttcaaatttg      300

aacttacccg ccgtttggat catgactttg ggaaggtcac caagcaggaa gtcaaagact      360

ttttccggtg ggctcaagat cacgtgactg aggtggagca tgagttctac gtcaaaaagg      420

gtggagccaa gaaaaggccc gcccccgatg atgtatatat aaatgagccc aagcgggcgc      480

gcgagtcagt tgcgcagcca tcgacgtcag acgcggaagc ttcgataaac tacgcggaca      540

ggtaccaaaa caaatgttct cgtcacgtgg gcatgaatct gatgctgttt ccctgtcgac      600

aatgcgaaag aatgaatcag aattcaaata tctgcttcac acacgggcaa aaagactgtt      660

tggaatgctt tcccgtgtca gaatctcaac ccgtttctgt cgtcagaaaa acgtatcaga      720

aactttgtta cattcatcat atcatgggaa aagtaccaga cgcctgcact gcctgcgacc      780

tggtaaatgt ggacttggat gactgtattt ctgagcaata aatgacttaa atcaggtatg      840

gctgctgacg gttatcttcc agattggctc gaggacactc tctctgaagg aatcagacag      900

tggtggaagc tcaaacctgg cccaccaccg ccgaaaccta accaacaaca ccgggacgac      960

agtaggggtc ttgtgcttcc tgggtacaag tacctcggac ccttcaacgg actcgacaaa     1020

ggagagccgg tcaacgaggc agacgccgcg gccctcgagc acgacaaagc ctacgaccac     1080

cagctcaagc aaggggacaa cccgtacctc aaatacaacc acgcggacgc tgaatttcag     1140

gagcgtcttc aagaagatac gtctttcggg ggcaacctcg ggcgagcagt cttccaggcc     1200

aaaaagaggg tactcgagcc tcttggtctg gttgaggaag ctgttaagac ggctcctgga     1260

aaaaagagac ctatagagca gtctcctgca gaaccggact cttcctcggg catcggcaaa     1320

tcaggccagc agcccgctaa gaaaagactc aattttggtc agactggcga cacagagtca     1380

gtcccaggcc ctcaaccaat cggagaaccc cccgcagccc cctctggtgt gggatctaat     1440

acaatggctt caggcggtgg ggcaccaatg gcagacaata acgaaggcgc cgacggagtg     1500

ggtaattcct cgggaaattg gcattgcgat tccacatgga tgggcgacag agttatcacc     1560

accagcacaa gaacctgggc cctccccacc tacaataatc acctctacaa gcaaatctcc     1620

agcgaatcgg gagccaccaa cgacaaccac tacttcggct acagcacccc ctgggggtat     1680

tttgacttta acagattcca ctgtcacttc tcaccacgtg actggcagcg actcatcaac     1740

aacaactggg gatttagacc caagaaactc aatttcaagc tcttcaacat ccaagtcaag     1800

gaggtcacgc agaatgatgg aaccacgacc atcgccaata accttaccag cgcggtgcag     1860

gtcttcacag actctgagta ccagctgccc tacgtcctcg gttcggctca ccagggctgc     1920

cttccgccgt tcccagcaga cgtcttcatg attcctcagt acggctactt gactctgaac     1980

aatggcagcc aagcggtagg acgttcttca ttctactgtc tagagtattt tccctctcag     2040

atgctgagga cgggaaacaa cttcaccttc agctacactt ttgaagacgt gcctttccac     2100

agcagctacg cgcacagcca gagtctggat cggctgatga atcctctcat tgaccagtac     2160

ctgtattacc tgagcaaaac tcagggtaca agtggaacaa cgcagcaatc gagactgcag     2220

ttcagccaag ctgggcctag ctccatggct cagcaggcca aaaactggct accgggaccc     2280

agctaccgac agcagcgaat gtctaagacg gctaatgaca acaacaacag tgaatttgct     2340

tggactgcag ccaccaaata ttacctgaat ggaagaaatt ctctggtcaa tcccgggccc     2400

ccagtggcca gtcacaagga cgatgaggaa aagtatttcc ccatgcacgg aaatctcatc     2460

tttggaaaac aaggcacagg aactaccaat gtggacattg aatcagtgct tattacagac     2520

gaagaagaaa tcagaacaac taatcctgtg gctacagaac aatacggaca ggttgccacc     2580

aaccatcaga gtcagaacac cacagcttcc tatggaagtg tggacagcca gggaatctta     2640

cctggaatgg tgtggcagga ccgcgatgtc tatcttcaag gtcccatttg ggccaaaact     2700

cctcacacgg acggacactt tcatccttct ccgctcatgg gaggctttgg actgaaacac     2760

cctcctcccc agatcctgat caaaaacaca cctgtgccag cgaatcccgc gaccactttc     2820

actcctggaa agtttgcttc gttcattacc cagtattcca cctgacaggt cagcgtggaa     2880

atagagtggg agctgcagaa agaaaacagc aaacgctgga acccagaaat tcagtacacc     2940

tccaactaca acaagtcggt gaatgtggag tttaccgtgg acgcaaacgg tgtttattct     3000

gaaccccgcc ctattggcac tcgttacctt acccggaact tgtaatttcc tgttaatgaa     3060

taagccgatt tatgcgtttc agttgaactt tggtctctgc gaagggcgaa ttcgtttaaa     3120

cct                                                                   3123


<210> 4808
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4808
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Asn Gln Gln His Arg Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


His Gln Leu Lys Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Gln Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Gly Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Glu Ser Gly Ala Thr Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Ala Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr 
        435                 440                 445             


Gln Gly Thr Ser Gly Thr Thr Gln Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Ser Ser Met Ala Gln Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Ser Tyr Arg Gln Gln Arg Met Ser Lys Thr Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Phe Ala Trp Thr Ala Ala Thr Lys Tyr Tyr Leu Asn Gly 
            500                 505                 510         


Arg Asn Ser Leu Val Asn Pro Gly Pro Pro Val Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Met His Gly Asn Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Gly Thr Thr Asn Val Asp Ile Glu Ser Val Leu Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Gln Val Ala Thr Asn His Gln Ser Gln Asn Thr Thr Ala Ser Tyr 
            580                 585                 590         


Gly Ser Val Asp Ser Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Thr Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ala Thr Thr Phe Thr Pro Gly Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Glu Phe Thr Val Asp Ala Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4809
<211> 3123
<212> DNA
<213> Adeno-associated virus

<400> 4809
gaattcgccc tttctacggc tgcgtcaact ggaccaatga aaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggaaagat gaccgccaag gtcgtggaat      120

ctgccaaagc cattctgggt ggaagcaagg ttcgtgtgga ccagaaatgc aagtcttcgg      180

cccagatcga cccgactccg gtgattgtca cctctaacac caacatgtgc gccgtgattg      240

acggaaactc gaccaccttc gagcaccagc agccgttgca agaccggatg ttcaaatttg      300

aacttacccg ccgtttggat catgactttg ggaaggtcac caagcaggaa gtcaaagact      360

ttttccggtg ggctcaagat cacgtgactg aggtggagca tgagttctac gtcaaaaagg      420

gtggagccaa gaaaaggccc gcccccgatg atgtatatat aaatgagccc aagcgggcgc      480

gcgagtcagt tgcgcagcca tcgacgtcag acgcggaagc ttcgataaac tacgcgggca      540

ggtaccaaaa caaatgttct cgtcacgtgg gcatgaatct gatgctgttt ccctgtcgac      600

aatgcgaaag aatgaatcag aattcaaata tctgcttcac acacgggcaa aaagactgtt      660

tggaatgctt tcccgtgtca gaatctcaac ccgtttctgt cgtcagaaaa acgtatcaga      720

aactttgtta cattcatcat atcatgggaa aagaaccaga cgcctgcact gcctgcgacc      780

tggtaaatgt ggacttggat gactgtattt ctgagcaata aatgacttaa atcaggtatg      840

gctgctgacg gttatcttcc agattggctc gaggacactc tctctgaagg aatcagacag      900

tggtggaagc tcaaacctgg cccaccaccg ccgaaaccta accaacaaca ccgggacgac      960

agtaggggtc ttgtgcttcc tgggtacaag tacctcggac ccttcaacgg actcgacaaa     1020

ggagagccgg tcaacgaggc agacgccgcg gccctcgagc acgacaaagc ctacgaccac     1080

cagctcaagc aaggggacaa cccgtacctc aaatacaacc acgcggacgc tgaatttcag     1140

gagcgtcttc aagaagatac gtctttcggg ggcaacctcg ggcgagcagt cttccaggcc     1200

aaaaagaggg tactcgagcc tcttggtctg gttgaggaag ctgttaagac ggctcctgga     1260

aaaaagagac ctatagagca gtctcctgca gaaccggact cttcctcggg catcggcgaa     1320

tcaggccagc agcccgctaa gaaaagactc aattttggtc agactggcga cacagagtca     1380

gtcccagacc ctcaaccaat cggagaaccc cccgcagccc cctctggtgt gggatctaat     1440

acaatggctt caggcggtgg ggcaccaatg gcagacgata acgaaggcgc cgacggagtg     1500

ggtaattcct cgggaaattg gcattgcgat tccacatgga tgggcgacag agttatcacc     1560

accagcacaa gaacctgggc cctccccacc tacaataatc acctctacaa gcaaatctcc     1620

agcgaatcgg gagccaccaa cgacaaccac tacttcggct acagcacccc ctgggggtat     1680

tttgacttta acagattcca ctgtcacttc tcaccacgtg actggcagcg actcatcaac     1740

aacaactggg gatttagacc caagaaactc aatttcaagc tcttcaacat ccaagtcaag     1800

gaggtcacgc agaatgatgg aaccacgacc atcgccaata accttaccag cacggtgcag     1860

gtcttcacag actctgagta ccagctgccc tacgtcctcg gttcggctca ccagggctgc     1920

cttccgccgt tcccagcaga cgtcttcatg attcctcagt acggctactt gactctgaac     1980

aatggcagcc aagcggtagg acgttcttca ttctactgtc tagagtattt tccctctcag     2040

atgctgagga cgggaaacaa cttcaccttc agctacactt ttgaagacgt gcctttccac     2100

agcagctacg cgcacagcca gagtctggat cggctgatga atcctctcat tgaccagtac     2160

ctgtattacc tgagcaaaac tcagggtaca agtggaacaa cgcagcaatc gagactgcag     2220

ttcagccaag ctgggcctag ctccatggct cagcaggcca aaaactggct accgggaccc     2280

agctaccgac agcagcgaat gtctaagacg gctaatgaca acaacaacag tgaatttgct     2340

tggactgcag ccaccaaata ttacctgaat ggaagaaatt ctctggtcaa tcccgggccc     2400

ccaatggcca gtcacaagga cgatgaggaa aagtatttcc ccatgcacgg aaatctcatc     2460

tttggaaaac aaggcacagg aactaccaat gtggacattg aatcagtgct tattacagac     2520

gaagaagaaa tcagaacaac taatcctgtg gctacagaac aatacggaca ggttgccacc     2580

aaccatcaga gtcaggacac cacagcttcc tatggaagtg tggacagcca gggaatctta     2640

cctggaatgg tgtggcagga ccgcgatgtc tatcttcaag gtcccatttg ggccaaaact     2700

cctcacacgg acggacactt tcatccttct ccgctcatgg gaggctttgg actgaaacac     2760

cctcctcccc agatcctgat caaaaacaca cctgtgccag cgaatcccgc gaccactttc     2820

actcctggaa agtttgcttc gttcattacc cagtattcca ccggacaggt cagcgtggaa     2880

atagagtggg agctgcagaa agaaaacagc aaacgctgga acccagaaat tcagtacacc     2940

tccaactaca acaagtcggt gaatgtggag tttaccgtgg acgcaaacgg tgtttattct     3000

gaaccccgcc ctattggcac tcgttacctt acccggaact tgtaatttcc tgttaatgaa     3060

taaaccgatt tatgcgtttc agttgaactt tggtctctgc gaagggcgaa ttcgcggccg     3120

cta                                                                   3123


<210> 4810
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4810
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Asn Gln Gln His Arg Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


His Gln Leu Lys Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Gln Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Glu Ser Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asp Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Glu Ser Gly Ala Thr Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr 
        435                 440                 445             


Gln Gly Thr Ser Gly Thr Thr Gln Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Ser Ser Met Ala Gln Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Ser Tyr Arg Gln Gln Arg Met Ser Lys Thr Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Phe Ala Trp Thr Ala Ala Thr Lys Tyr Tyr Leu Asn Gly 
            500                 505                 510         


Arg Asn Ser Leu Val Asn Pro Gly Pro Pro Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Met His Gly Asn Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Gly Thr Thr Asn Val Asp Ile Glu Ser Val Leu Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Gln Val Ala Thr Asn His Gln Ser Gln Asp Thr Thr Ala Ser Tyr 
            580                 585                 590         


Gly Ser Val Asp Ser Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Thr Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ala Thr Thr Phe Thr Pro Gly Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Glu Phe Thr Val Asp Ala Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4811
<211> 3113
<212> DNA
<213> Adeno-associated virus

<400> 4811
gaattcgccc tttctacggc tgcgtcaact ggaccaatga aaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggaaagat gaccgccaag gtcgtggaat      120

ctgccaaagc cattctgggt ggaagcaagg ttcgtgtgga ccagaaatgc aagtcttcgg      180

cccagatcga cccgactccg gtgattgtca cctctaacac caacatgtgc gccgtgattg      240

acggaaactc gaccaccttc gagcaccagc agccgttgca agaccggatg ttcaaatttg      300

aacttacccg ccgtttggat catgactttg ggaaggtcac caagcaggaa gtcaaagact      360

ttttccggtg ggctcaagat cacgtgactg aggtggagca tgagttctac gtcaaaaagg      420

gtggagccaa gaaaaggccc gcccccgatg atgtatatat aaatgagccc aagcgggcgc      480

gcgagtcagt tgcgcagcca tcgacgtcag acgcggaagc ttcgataaac tacgcggaca      540

ggtaccaaaa caaatgttct cgtcacgtgg gcatgaatct gatgctgttt ccctgtcgac      600

aatgcgaaag aatgaatcag aattcaaata tctgcttcac acacgggcaa aaagactgtt      660

tggaatgctt tcccgtgtca gaatctcaac ccgttcctgt cgtcagaaaa acgtatcaga      720

aactttgtta cattcatcat atcatgggaa aagtaccaga cgcctgcact gcctgcgacc      780

tggtaaatgt ggacttggat gactgtattt ctgagcaata aatgacttaa atcaggtatg      840

gctgctgacg gttatcttcc agattggctc gaggacactc tctctgaagg aatcagacag      900

tggtggaagc tcaaacctgg cccaccaccg ccgaaaccta accaacaaca ccgggacgac      960

agtaggggtc ttgtgcttcc tgggtacaag tacctcggac ccttcaacgg actcgacaaa     1020

ggagagccgg tcaacgaggc agacgccgcg gccctcgagc acgacaaagc ctacgaccac     1080

cagctcaagc aaggggacaa cccgtacctc aaatacaacc acgcggacgc tgaatttcag     1140

gagcgtcttc aagaagatac gtctttcggg ggcaacctcg ggcgagcagt cttccaggcc     1200

aaaaagaggg tactcgagcc tcttggtctg gttgaggaag ctgttaagac ggctcctgga     1260

aaaaagagac ctatagagca gtctcctgca gaaccggact cttcctcggg catcggcaaa     1320

tcaggccagc agcccgctaa gaaaagactc aattttggtc agactggcga cacagagtca     1380

gtcccagacc ctcaaccaat cggagaaccc cccgcagccc cctctggtgt gggatctaat     1440

acaatggctt caggcggtgg ggcaccaatg gcagacaata acgaaggcgc cgacggagtg     1500

ggtaattcct cgggaaattg gcattgcgat tccacatgga tgggcgacag agttatcacc     1560

accagcacaa gaacctgggc cctccccacc tacaataatc acctctacaa gcaaatctcc     1620

agcgaatcgg gagccaccaa cgacaaccac tacttcggct acagcacccc ctgggggtat     1680

tttgacttta acagattcca ctgtcacttc tcaccacgtg actggcagcg actcatcaat     1740

aacaactggg gatttagacc caagaaactc aatttcaagc tcttcaacat ccaagtcaag     1800

gaggtcacgc agaatgatgg aaccacgacc atcgccaata accttaccag cacggtgcag     1860

gtcttcacag actctgagta ccagctgccc tacgtcctcg gttcggctca ccagggctgc     1920

cttccgccgt tcccagcaga cgtcttcatg attcctcagt acggctactt gactctgaac     1980

aatggcagcc aagcggtagg acgttcttca ttctactgtc tagagtattt tccctctcag     2040

atgctgagga cgggaaacaa cttcaccttc agctacactt ttgaagacgt gcctttccac     2100

agcagctacg cgcacagcca gagtctggat cggctgatga atcctctcat tgaccagtac     2160

ctgtattacc tgagcaaaac tcagggtaca agtggaacaa cgcagcaatc gagactgcag     2220

ttcaaccaag ctgggcctag ctccatggct cagcaggcca aaaactggct accgggaccc     2280

agctaccgac agcagcgaat gtctaagacg gctaatgaca acaacaacag tgaatttgct     2340

tggactgcag ccaccaaata ttacccgaat ggaagaaatt ctctggtcaa tcccgggccc     2400

ccaatggcca gtcacaagga cgatgaggaa aagtatttcc ccatgcacgg aaatctcatc     2460

tttggaaaac aaggcacagg aactaccaat gtggacattg aatcagtgct tattacagac     2520

gaagaagaaa tcagaacgac taatcctgtg gctacagaac aatacggaca ggttgccacc     2580

aaccgtcaga gtcagaacac cacagcttcc tatggaagtg tggacagcca gggaatctta     2640

cctggaatgg tgtggcagga ccgcgatgtc tatcttcaag gtcccatttg ggccaaaact     2700

cctcacacgg acggacactt tcatccttct ccgctcatgg gaggctttgg actgaaacac     2760

cctcctcccc agatcctgat caaaaacaca cctgtgccag cgaatcccgc gaccactttc     2820

actcctggaa agtttgcttc gttcattacc cagtattcca ccggacaggt cagcgtggaa     2880

atagagtggg agctgcagaa agaaaacagc aaacgctgga acccggaaat tcagtacacc     2940

tccaactaca acaagtcggt gaatgtggag tttaccgtgg acgcaaacgg tgtttattct     3000

gaaccccgcc ctattggcac tcgttacctt acccggaact tgtaatttcc tgttaatgaa     3060

taaaccgatt tatgcgtttc agttgaactt tggtctctgc gaagggcgaa ttc            3113


<210> 4812
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4812
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Asn Gln Gln His Arg Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


His Gln Leu Lys Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Gln Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Glu Ser Gly Ala Thr Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr 
        435                 440                 445             


Gln Gly Thr Ser Gly Thr Thr Gln Gln Ser Arg Leu Gln Phe Asn Gln 
    450                 455                 460                 


Ala Gly Pro Ser Ser Met Ala Gln Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Ser Tyr Arg Gln Gln Arg Met Ser Lys Thr Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Phe Ala Trp Thr Ala Ala Thr Lys Tyr Tyr Pro Asn Gly 
            500                 505                 510         


Arg Asn Ser Leu Val Asn Pro Gly Pro Pro Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Met His Gly Asn Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Gly Thr Thr Asn Val Asp Ile Glu Ser Val Leu Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Gln Val Ala Thr Asn Arg Gln Ser Gln Asn Thr Thr Ala Ser Tyr 
            580                 585                 590         


Gly Ser Val Asp Ser Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Thr Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ala Thr Thr Phe Thr Pro Gly Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Glu Phe Thr Val Asp Ala Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4813
<211> 3122
<212> DNA
<213> Adeno-associated virus

<400> 4813
agcggccgcg aattcgccct ttctacggct gcgtcaactg gaccaatgaa aactttccct       60

tcaacgattg cgtcgacaag atggtgatct ggtgggagga gggaaagatg accgccaagg      120

tcgtggaatc tgccaaagcc attctgggtg gaagcaaggt tcgtgtggac cagaaatgca      180

ggtcttcggc ccagatcgac ccgactccgg tgattgtcac ctctaacacc aacatgtgcg      240

ccgtgattga cggaaactcg accaccttcg agcaccagca gccgttgcaa gaccggatgt      300

tcaaatttga acttacccgc cgtttggatc atgactttgg gaaggtcacc aagcaggaag      360

tcaaagactt tttccggtgg gctcaagatc acgtgactga ggtggagcat gagttctacg      420

tcaaaaaggg tggagccaag aaaaggcccg cccccgatga tgtatatata aatgagccca      480

agcgggcgcg cgagtcagtt gcgcagccat cgacgtcaga cgcggaagct tcgataaact      540

acgcggacag gtaccaaaac aaatgttctc gtcacgtggg catgaatctg atgctgtttc      600

cctgtcgaca atgcgaaaga atgaatcaga attcaaatat ctgcttcaca cacgggcaaa      660

aagactgttt ggaatgcttt cccgtgtcag aatctcaacc cgtttctgtc gtcagaaaaa      720

cgtatcagaa actttgttac attcatcata tcatgggaaa agtaccagac gcctgcactg      780

cctgcgacct ggtaaatgtg gacttggatg actgtatttc tgagcaataa atgacttaaa      840

tcaggtatgg ctgctgacgg ttatcttcca gattggctcg aggacactct ctctgaagga      900

atcagacagt ggtggaagct caaacctggc ccaccaccgc cgaaacctaa ccaacaacac      960

cgggacgaca gtaggggtct tgtgcttcct gggtacaagt acctcggacc cttcaacgga     1020

ctcgacaaag gagagccggt caacgaggca gacgccgcgg ccctcgagca cgacaaagcc     1080

tacgaccacc agctcaagca aggggacaac ccgtacctca aatacaacca cgcggacgct     1140

gaatttcagg agcgtcttca agaagatacg tctttcgggg gcaacctcgg gcgagcagtc     1200

ttccaggcca aaaagagggt actcgagcct cttggtctgg ttgaggaagc tgttaagacg     1260

gctcctggaa aaaagagacc tatagagcag tctcctgcag aaccggactc ttcctcgggc     1320

atcggcaaat caggccagca gcccgctaag aaaagactca attttggtca gactggcgac     1380

acagagtcag tcccagaccc tcaaccaatc ggagaacccc ccgcagcccc ctctggtgtg     1440

ggatctaata caatggcttc aggcggtggg gcaccaatgg cagacaataa cgaaggcgcc     1500

gacggagtgg gtaattcctc gggaaattgg cattgcgatt ccacatggat gggcgacaga     1560

gttatcacca ccagcacaag aacctgggcc ctccccacct acaataatcg cctctacaag     1620

caaatctcca gcgaatcggg agccaccaac gacaaccact acttcggcta cagcaccccc     1680

tgggggtatt ttgactttaa cagattccac tgtcacttct caccacgtga ctggcagcga     1740

ctcatcaaca acaactgggg atttagaccc aagaaactca atttcaagct cttcaacatc     1800

caagtcaagg aggtcacgca gaatgatgga accacgacca tcgccaataa ccttaccagc     1860

acggtgcagg tcttcacaga ctctgagtac cagctgccct acgtcctcgg ttcggctcac     1920

cagggctgcc ttccgccgtt cccagcagac gtcttcatga ttcctcagta cggctacttg     1980

actctgaaca atggcagcca agcggtagga cgttcttcat tctactgtct agagtatttt     2040

ccctctcaga tgctgaggac gggaaacaac ttcaccttca gctacacttt tgaagacgtg     2100

cctttccaca gcagctacgc gcacagccag agtctggatc ggctgatgaa tcctctcatt     2160

gaccagtacc tgtattacct gagcaaaact cagggtacaa gtggaacaac gcagcaatcg     2220

agactgcagt tcagccaagc tgggcctagc tccatggctc agcaggccaa aaactggcta     2280

ccgggaccca gctaccgaca gcagcgaatg tctaagacgg ctaatgacaa caacaacagt     2340

gaatttgctt ggactgcagc caccaaatat tacctgaatg gaagaaattc tctggtcaat     2400

cccgggcccc caatggccag tcacaaggac gatgaggaaa agtatttccc catgcacgga     2460

aatctcatct ttggaaaaca aggcacagga actaccaatg tggacattga atcagtgctt     2520

attacagacg aagaagaaat cagaacaact aatcctgtgg ctacagaaca atacggacag     2580

gttgccacca accatcagag tcagaacacc acagcttcct atggaagtgt ggacagccag     2640

ggaatcttac ctggaatggt gtggcaggac cgcgatgtct atcttcaagg tcccatttgg     2700

gccaaaactc ctcacacgga cggacacttt catccttctc cgctcatggg aggctttgga     2760

ctgaaacacc ctcctcccca gatcctgatc aaaaacacac ctgtgccagc gaatcccgcg     2820

accactttca ctcctggaaa gtttgcttcg ttcattaccc agtattccac cggacaggtc     2880

agcgtggaaa tagagtggga gctgcagaaa gaaaacagca aacgctggaa cccagaaatt     2940

cagtacacct ccaactacaa caagtcggtg aatgtggagt ttaccgtgga cgcaaacggt     3000

gtttattctg aaccccgccc tattggcact cgttacctta cccggaactt gtaatttcct     3060

gttaatgaat aaaccgattt atgcgtttca gttgaacttt ggtctctgcg aagggcgaat     3120

tc                                                                    3122


<210> 4814
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4814
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Asn Gln Gln His Arg Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


His Gln Leu Lys Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Gln Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn Arg Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Glu Ser Gly Ala Thr Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr 
        435                 440                 445             


Gln Gly Thr Ser Gly Thr Thr Gln Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Ser Ser Met Ala Gln Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Ser Tyr Arg Gln Gln Arg Met Ser Lys Thr Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Phe Ala Trp Thr Ala Ala Thr Lys Tyr Tyr Leu Asn Gly 
            500                 505                 510         


Arg Asn Ser Leu Val Asn Pro Gly Pro Pro Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Met His Gly Asn Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Gly Thr Thr Asn Val Asp Ile Glu Ser Val Leu Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Gln Val Ala Thr Asn His Gln Ser Gln Asn Thr Thr Ala Ser Tyr 
            580                 585                 590         


Gly Ser Val Asp Ser Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Thr Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ala Thr Thr Phe Thr Pro Gly Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Glu Phe Thr Val Asp Ala Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4815
<211> 733
<212> PRT
<213> Adeno-associated virus

<400> 4815
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Leu Glu Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly Lys 
145                 150                 155                 160 


Lys Gly Lys Gln Pro Ala Lys Lys Arg Leu Asn Phe Glu Glu Asp Thr 
                165                 170                 175     


Gly Ala Gly Asp Gly Pro Pro Glu Gly Ser Asp Thr Ser Ala Met Ser 
            180                 185                 190         


Ser Asp Ile Glu Met Arg Ala Ala Pro Gly Gly Asn Ala Val Asp Ala 
        195                 200                 205             


Gly Gln Gly Ser Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys 
    210                 215                 220                 


Asp Ser Thr Trp Ser Glu Gly Lys Val Thr Thr Thr Ser Thr Arg Thr 
225                 230                 235                 240 


Trp Val Leu Pro Thr Tyr Asn Asn His Leu Tyr Leu Arg Leu Gly Thr 
                245                 250                 255     


Thr Ser Asn Ser Asn Thr Tyr Asn Gly Phe Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Asn Trp Gly Leu Arg Pro Lys Ala Met Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Thr Ser Asn Gly Glu 
305                 310                 315                 320 


Thr Thr Val Ala Asn Asn Leu Thr Ser Thr Val Gln Ile Phe Ala Asp 
                325                 330                 335     


Ser Ser Tyr Glu Leu Pro Tyr Val Met Asp Ala Gly Gln Glu Gly Ser 
            340                 345                 350         


Leu Ser Pro Phe Pro Asn Asp Val Phe Met Val Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Cys Gly Ile Val Thr Gly Glu Asn Gln Asn Gln Thr Asp Arg Asn Ala 
    370                 375                 380                 


Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Glu Met Ala Tyr Asn Phe Gly Lys Val Pro Phe His Ser Met 
                405                 410                 415     


Tyr Ala Tyr Ser Gln Ser Pro Asp Arg Leu Met Asn Pro Leu Leu Asp 
            420                 425                 430         


Gln Tyr Leu Trp His Leu Gln Ser Thr Thr Ser Gly Glu Thr Leu Asn 
        435                 440                 445             


Gln Gly Asn Ala Ala Thr Thr Phe Gly Lys Ile Arg Ser Gly Asp Phe 
    450                 455                 460                 


Ala Phe Tyr Arg Lys Asn Trp Leu Pro Gly Pro Cys Val Lys Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Thr Ala Ser Gln Asn Tyr Lys Ile Pro Ala Ser Gly 
                485                 490                 495     


Gly Asn Ala Leu Leu Lys Tyr Asp Thr His Tyr Thr Leu Asn Asn Arg 
            500                 505                 510         


Trp Ser Asn Ile Ala Pro Gly Pro Pro Met Ala Thr Ala Gly Pro Ser 
        515                 520                 525             


Asp Gly Asp Phe Ser Asn Ala Gln Leu Ile Phe Pro Gly Pro Ser Val 
    530                 535                 540                 


Thr Gly Asn Thr Thr Thr Ser Ala Asn Asn Leu Leu Phe Thr Ser Glu 
545                 550                 555                 560 


Glu Glu Ile Ala Ala Thr Asn Pro Arg Asp Thr Asp Met Phe Gly Gln 
                565                 570                 575     


Ile Ala Asp Asn Asn Gln Asn Ala Thr Thr Ala Pro Ile Thr Gly Asn 
            580                 585                 590         


Val Thr Ala Met Gly Val Leu Pro Gly Met Val Trp Gln Asn Arg Asp 
        595                 600                 605             


Ile Tyr Tyr Gln Gly Pro Ile Trp Ala Lys Ile Pro His Ala Asp Gly 
    610                 615                 620                 


His Phe His Pro Ser Pro Leu Ile Gly Gly Phe Gly Leu Lys His Pro 
625                 630                 635                 640 


Pro Pro Gln Ile Phe Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Ala 
                645                 650                 655     


Thr Thr Phe Thr Ala Ala Arg Val Asp Ser Phe Ile Thr Gln Tyr Ser 
            660                 665                 670         


Thr Gly Gln Val Ala Val Gln Ile Glu Trp Glu Ile Glu Lys Glu Arg 
        675                 680                 685             


Ser Lys Arg Trp Asn Pro Glu Val Gln Phe Thr Ser Asn Tyr Gly Asn 
    690                 695                 700                 


Gln Ser Ser Met Leu Trp Ala Pro Asp Thr Thr Gly Lys Tyr Thr Glu 
705                 710                 715                 720 


Pro Arg Val Ile Gly Ser Arg Tyr Leu Thr Asn His Leu 
                725                 730             


<210> 4816
<211> 733
<212> PRT
<213> Adeno-associated virus

<400> 4816
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Leu 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe His Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Leu Glu Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly Lys 
145                 150                 155                 160 


Lys Gly Lys Gln Pro Ala Lys Lys Arg Leu Asn Phe Glu Glu Asp Thr 
                165                 170                 175     


Gly Ala Gly Asp Gly Pro Pro Glu Gly Ser Asp Thr Ser Ala Met Ser 
            180                 185                 190         


Ser Asp Ile Glu Met Arg Ala Ala Pro Gly Gly Asn Ala Val Asp Ala 
        195                 200                 205             


Gly Gln Gly Ser Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys 
    210                 215                 220                 


Asp Ser Thr Trp Ser Glu Gly Lys Val Thr Thr Thr Ser Thr Arg Thr 
225                 230                 235                 240 


Trp Val Leu Pro Thr Tyr Asn Asn His Leu Tyr Leu Arg Leu Gly Thr 
                245                 250                 255     


Thr Ser Asn Ser Asn Thr Tyr Asn Gly Phe Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Asn Trp Gly Leu Arg Pro Lys Ala Met Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Thr Ser Asn Gly Glu 
305                 310                 315                 320 


Thr Thr Val Ala Asn Asn Leu Thr Ser Thr Val Gln Ile Phe Ala Asp 
                325                 330                 335     


Ser Ser Tyr Glu Leu Pro Tyr Val Met Asp Ala Gly Gln Glu Gly Ser 
            340                 345                 350         


Leu Pro Pro Phe Pro Asn Asp Val Phe Met Val Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Cys Gly Ile Val Thr Gly Glu Asn Gln Asn Gln Thr Asp Arg Asn Ala 
    370                 375                 380                 


Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Glu Met Ala Tyr Asn Phe Glu Lys Val Pro Phe His Ser Met 
                405                 410                 415     


Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Leu Asp 
            420                 425                 430         


Gln Tyr Leu Trp His Leu Gln Ser Thr Thr Ser Gly Glu Thr Leu Asn 
        435                 440                 445             


Gln Gly Asn Ala Ala Thr Thr Phe Gly Lys Ile Arg Ser Gly Asp Phe 
    450                 455                 460                 


Ala Phe Tyr Arg Lys Asn Trp Leu Pro Gly Pro Cys Val Lys Gln Gln 
465                 470                 475                 480 


Arg Phe Ser Lys Thr Ala Ser Gln Asn Tyr Lys Ile Pro Ala Ser Gly 
                485                 490                 495     


Gly Asn Ala Leu Leu Lys Tyr Asp Thr His Tyr Thr Leu Asn Asn Arg 
            500                 505                 510         


Trp Ser Asn Ile Ala Pro Gly Pro Pro Met Ala Thr Ala Gly Pro Ser 
        515                 520                 525             


Asp Gly Asp Phe Ser Asn Ala Gln Leu Ile Phe Pro Gly Pro Ser Val 
    530                 535                 540                 


Thr Gly Asn Thr Thr Thr Ser Ala Asn Asn Leu Leu Phe Thr Ser Glu 
545                 550                 555                 560 


Gly Glu Ile Ala Ala Thr Asn Pro Arg Asp Thr Asp Met Phe Gly Gln 
                565                 570                 575     


Ile Ala Asp Asn Asn Gln Asn Ala Thr Thr Ala Pro Ile Thr Gly Asn 
            580                 585                 590         


Val Thr Ala Met Gly Val Leu Pro Gly Met Val Trp Gln Asn Arg Asp 
        595                 600                 605             


Ile Tyr Tyr Gln Gly Pro Ile Trp Ala Lys Ile Pro His Ala Asp Gly 
    610                 615                 620                 


His Phe His Pro Ser Pro Leu Ile Gly Gly Phe Gly Leu Lys His Pro 
625                 630                 635                 640 


Pro Pro Gln Ile Phe Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Ala 
                645                 650                 655     


Thr Thr Phe Thr Ala Ala Arg Val Asp Ser Phe Ile Thr Gln Tyr Ser 
            660                 665                 670         


Thr Gly Gln Val Ala Val Gln Ile Glu Trp Glu Ile Glu Lys Glu Arg 
        675                 680                 685             


Ser Lys Arg Arg Asn Pro Glu Val Gln Phe Thr Ser Asn Tyr Gly Asn 
    690                 695                 700                 


Gln Ser Ser Met Leu Trp Ala Pro Asp Thr Thr Gly Lys Tyr Thr Glu 
705                 710                 715                 720 


Pro Arg Val Ile Gly Ser Arg Tyr Leu Thr Asn His Leu 
                725                 730             


<210> 4817
<211> 733
<212> PRT
<213> Adeno-associated virus

<400> 4817
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Glu Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Leu Glu Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly Lys 
145                 150                 155                 160 


Lys Gly Lys Gln Pro Ala Lys Lys Arg Leu Asn Phe Glu Glu Asp Thr 
                165                 170                 175     


Gly Ala Gly Asp Gly Pro Pro Glu Gly Ser Asp Thr Ser Ala Met Ser 
            180                 185                 190         


Ser Asp Ile Glu Met Arg Ala Ala Pro Gly Gly Asn Ala Val Asp Ala 
        195                 200                 205             


Gly Gln Gly Ser Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys 
    210                 215                 220                 


Asp Ser Thr Trp Ser Glu Gly Lys Val Thr Thr Thr Ser Thr Arg Thr 
225                 230                 235                 240 


Trp Val Leu Pro Thr Tyr Asn Asn His Leu Tyr Leu Arg Leu Gly Thr 
                245                 250                 255     


Thr Ser Asn Ser Asn Thr Tyr Asn Gly Phe Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Asn Trp Gly Leu Arg Pro Lys Ala Met Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Thr Ser Asn Gly Glu 
305                 310                 315                 320 


Thr Thr Val Ala Asn Asn Leu Thr Ser Thr Val Gln Ile Phe Ala Asp 
                325                 330                 335     


Ser Ser Tyr Glu Leu Pro Tyr Val Met Asp Ala Gly Gln Glu Gly Ser 
            340                 345                 350         


Leu Pro Pro Phe Pro Asn Asp Val Phe Met Val Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Cys Gly Ile Val Thr Gly Glu Asn Gln Asn Gln Thr Asp Arg Asn Ala 
    370                 375                 380                 


Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Glu Thr Ala Tyr Asn Phe Glu Lys Val Pro Phe His Ser Met 
                405                 410                 415     


Tyr Ala His Ser Gln Ser Leu Asp Gly Leu Met Asn Pro Leu Leu Asp 
            420                 425                 430         


Gln Tyr Leu Trp His Leu Gln Ser Thr Thr Ser Gly Glu Thr Leu Asn 
        435                 440                 445             


Gln Gly Asn Ala Ala Thr Thr Phe Gly Lys Ile Arg Ser Gly Asp Phe 
    450                 455                 460                 


Ala Phe Tyr Arg Lys Asn Trp Leu Pro Gly Pro Cys Val Lys Gln Gln 
465                 470                 475                 480 


Arg Phe Ser Lys Thr Ala Ser Gln Asn Tyr Lys Ile Pro Ala Ser Gly 
                485                 490                 495     


Gly Asn Ala Leu Leu Lys Tyr Asp Thr His Tyr Thr Leu Asn Asn Arg 
            500                 505                 510         


Trp Ser Asn Ile Ala Pro Gly Pro Pro Met Ala Thr Ala Gly Pro Ser 
        515                 520                 525             


Asp Gly Asp Phe Ser Asn Ala Gln Leu Ile Phe Pro Gly Pro Ser Val 
    530                 535                 540                 


Thr Gly Asn Thr Thr Thr Ser Ala Asn Asn Leu Leu Phe Thr Ser Glu 
545                 550                 555                 560 


Glu Glu Ile Ala Ala Thr Asn Pro Arg Asp Thr Asp Met Phe Gly Gln 
                565                 570                 575     


Ile Ala Asp Asn Asn Gln Asn Ala Thr Thr Ala Pro Ile Thr Gly Asn 
            580                 585                 590         


Val Thr Ala Met Gly Val Leu Pro Gly Met Val Trp Gln Asn Arg Asp 
        595                 600                 605             


Ile Tyr Tyr Gln Gly Pro Ile Trp Ala Lys Ile Pro His Ala Asp Gly 
    610                 615                 620                 


His Phe His Pro Ser Pro Leu Ile Gly Gly Phe Gly Leu Lys His Pro 
625                 630                 635                 640 


Pro Pro Gln Ile Phe Ile Lys Asn Thr Pro Val Pro Ala Tyr Pro Ala 
                645                 650                 655     


Thr Thr Phe Thr Ala Ala Arg Val Asp Ser Phe Ile Thr Gln Tyr Ser 
            660                 665                 670         


Thr Gly Gln Val Ala Val Gln Ile Glu Trp Glu Ile Glu Lys Glu Arg 
        675                 680                 685             


Ser Lys Arg Trp Asn Pro Glu Val Gln Phe Thr Ser Asn Cys Gly Asn 
    690                 695                 700                 


Gln Ser Ser Met Leu Trp Ala Pro Asp Thr Thr Gly Lys Tyr Thr Glu 
705                 710                 715                 720 


Pro Arg Val Ile Gly Ser Arg Tyr Leu Thr Asn His Leu 
                725                 730             


<210> 4818
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4818
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Asn Gln Gln His Arg Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


His Gln Leu Lys Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Gln Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Glu Ser Gly Ala Thr Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr 
        435                 440                 445             


Gln Gly Thr Ser Gly Thr Thr Gln Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Ser Ser Met Ala Gln Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Ser Tyr Arg Gln Gln Arg Met Ser Lys Thr Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Phe Ala Trp Thr Ala Ala Thr Lys Tyr Tyr Leu Asn Gly 
            500                 505                 510         


Arg Asn Ser Leu Val Asn Pro Gly Pro Pro Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Met His Gly Asn Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Gly Thr Thr Asn Val Asp Ile Glu Ser Val Leu Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Gln Val Ala Thr Asn His Gln Ser Gln Asn Thr Thr Ala Ser Tyr 
            580                 585                 590         


Gly Ser Val Asp Ser Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ala Thr Thr Phe Thr Pro Gly Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Glu Phe Thr Val Asp Ala Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4819
<211> 3127
<212> DNA
<213> Adeno-associated virus

<400> 4819
gcggccgcga attcgccctt cgcagagacc aaagttcaac tgaaacgaat caaccggttt       60

attgattaac atgcaattac agattacggg tgaggtaacg agtgccaata gggcgaggct      120

cagagtaaac accctggctg tcaacggcaa agtccacacc agtctgcttt tcaaagttgg      180

aggtgtactg aatctccggg tcccagcgct tgctgttttc cttctgcagc tcccactcga      240

tttccacgct gacttgtccg gtgctgtact gtgtgatgaa cgaagcaaac ttggcaggag      300

taaacacctc cggaggatta gcgggaacgg gagtgttctt gatcaggatc tgaggaggcg      360

gatgtttaag tccaaagccg cccatcaaag gagacgggtg aaagttgcca tccgtgtgag      420

gaatcttggc ccagatggga ccctgcaggt acacgtcccg gttctgccag accatgccag      480

gtaaggctcc ctggttgttg acaacttgtg tctgggctgc agtattagcc gcttgtaagt      540

tgctgctgac tatcccgtat tcttccgtgg ctacaggatt agtaggacga atttcttctt      600

catttgtcat taacacattt tccaatgtag ttttgttagt tgctccagtt tttccaaaaa      660

tcaggactcc gctggatggg aaaaagcggt cctcgtcgtc cttgtgagtt gccatggcga      720

cgccgggatt aaccaacgag tttctgccgt tcaggtgata tttggtggca ccagtccaag      780

caaagttgct gttgttgttt tgatccagcg ttttggagac cctttgttgc cggaagcagg      840

gtccaggtaa ccaattcttg gcttgttcgg ccatagttga aggcccgccc tggtaaaact      900

gcagttcccg attgccagct gtgcctcctg ggtcactctg tgttctggcc aggtagtaca      960

agtactggtc gatgagggga ttcatcagcc ggtccaggct ctggctgtgt gcgtagctgc     1020

tgtggaaagg cacgtcctcg aagctgtagc tgaactcaaa gttgttgccc gttctcagca     1080

tctgagaggg gaagtactcc aggcagtaga aggaggaacg tcccacagac tgactgccat     1140

tgttgagagt caggtagccg tactgaggaa tcatgaagac gtccgccggg aacggaggca     1200

ggcagccctg gtgcgcagag ccgaggacgt acggcagctg gtattccgag tccgagaata     1260

cctgaatcgt gctggtaagg ttattagcga tggtcgtaac gccgtcattc gtcgtgacct     1320

ccttgacctg gatgttgaag agcttgaacc gcagcttctt gggccggaat ccccagttgt     1380

tgttgatgag tcgctgccag tcacgtggtg agaagtggca gtggaatctg ttaaagtcaa     1440

aataccccca gggggtgctg tagccgaagt aggtgttgtc gttggtacta cctgcagttt     1500

cactggagat ttgctcgtag aggtggttgt tgtaggtggg cagggcccag gttcgggtgc     1560

tggtggtaat gactctgtcg cccagccatg tggaatcgca atgccaattt cctgaggcat     1620

tacccactcc gtcggcacct tcgttattgt ctgccattgg tgcgccaccg cctgcagcca     1680

ctgtaccaga tcccacacta gagggcgctg ctggaggttc tccgagaggt tgagggtcgg     1740

ggactgactc tgagtcgcca gtctgaccga aattgagtct ctttctggcg ggctgctggc     1800

ccttcttgcc gatgcccgtg gaggagtcgg gggaacgctg aggtgacggc tctaccggtc     1860

tcttctttgc aggagccgtc ttagcgcctt cctcaaccag accgagaggt tcgagaaccc     1920

gcttcttggc ctggaagact gctcgcccga ggttgccccc aaatgacgta tcttcttgca     1980

gacgctcctg aaactcggcg tcggcgtggt tataccgcag gtacgggttg tcacccgcat     2040

tgagctgctg gtcgtaggcc ttgtcgtgct cgagggccgc tgcgtccgcc gcgttgacgg     2100

gctccccctt gtcgagtccg ttgaagggtc cgaggtactt gtagccagga agcaccagac     2160

cccggccgtt gtcctgcttt tgctggttgg ctttgggttt cggggctcca ggtttcaggt     2220

cccaccactc gcgaatgccc tcagagaggt tgtcctcgag ccaatctgga agataaccat     2280

cggcagccat acctgattta aatcatttat tgttcaaaga tgcagtcatc caaatccaca     2340

ttgaccagat cgcaggcagt gcaagcgtct ggcacctttc ccatgatatg atgaatgtag     2400

cacagtttct gatacgcctt tttgacgaca gaaacgggtt tagattctga cacgggaaag     2460

cactctaaac agtctttctg tccgtgagtg aagcagatat ttgaattctg attcattctc     2520

tcgcattgtc tgcagggaaa cagcatcaga ttcatgccca cgtgacgaga acatttgttt     2580

tggtacctgt ctgcgtagtt gatcgaagct tccgcgtctg acgtcgatgg ctgcgcaact     2640

gactcgcgca cccgtttggg ctcacttata tctgcgtcac tgggggcggg tcttttcttg     2700

gctccaccct ttttgacgta gaattcatgc tccacctcaa ccacgtaatc ctttgcccac     2760

cggaaaaagt ctttgacttc ctgcttggtg accttcccaa agtcatgatc cagacggcgg     2820

gtgagttcaa atttgaacat ccggtcttgc aacggctgct ggtgttcgaa ggtcgttgag     2880

ttcccgtcga tcacggcgca catgttggtg ttggagatga cgatcgcggg agtcgggtct     2940

atctgggccg aggacttgca tttctggtcc acgcgcacct tgcttcctcc gagaatggct     3000

ttggccgact ccacgacctt ggcggtcatc ttcccctcct cccaccagat caccatcttg     3060

tcgacacagt cgttgaaggg aaagttctca ttggtccagt tgacgcagcc gtagaaaggg     3120

cgaattc                                                               3127


<210> 4820
<211> 3106
<212> DNA
<213> Adeno-associated virus

<400> 4820
gcggccgcga attcgccctt cgcagagacc aaagttcaac tgaaacgaat caaccggttt       60

attgattaac aagtaattac aggttacggg tgaggtaacg ggtgccaatg gggcgaggct      120

cagtataaac cccttcgttg ttgacagcaa attccacatt attagacttg gcataatttg      180

aggtgtactg aatctctgga ttccagcgtt tgctgttttc tttctgcagt tcccactcga      240

tctccacgct gacctggccg gtgctgtact gcgtgataaa tgaggcaaac ttggcaggag      300

taaacacctc tggaggatta gcaggtaccg gggtgttttt gatgagaatt tgaggaggcg      360

ggtgtttgag tccaaatccg cccatcaggg gagacgggtg aaagttgccg tccgtgtgag      420

gaattttggc ccagatggga ccctgcaggc acacgtcccg gttctgccag accatgccgg      480

gcagagcccc ctggctgttg acagtctgtg tctggggtcc ggccgtagac gattgcaggt      540

tgctggagac cacaccgtat tcttctgtag ccacgggatt ggtggttttg atctcctcct      600

cgctggtcat tagcacgttt tccagcgttg tcttgttggc agcccccgtt ttgccaaaaa      660

ccagcactcc gttgatggga aagaactggt cctcgtcgtc cttgttggtg gccatggcta      720

cgcccgggtt ggttaatgaa tttctaccat tcagatggta tttagtggcc ccggtccagg      780

caaagttact gttgttgttg ctgtctatgt tttttgacag tctctgctgc cgataacagg      840

gtccgggcag ccagttcttt gattgctcgg ccatggtgtt gggcccagcc tgatggaact      900

gcagctccct tgtggacccc gtagtgctct gggtccgggc caggtagtac aggtactggt      960

cgatgagggg attcatcagc cggtctaggc tctggctgtg cacatagctg ctgtggaaag     1020

gcacttcctc aaaggtgtag ctgaattcaa agttattgcc cgttctcagc atctgagaag     1080

gaaagtactc caggcagtag aaggaggaac gtcccacaga ctgactgccg ttgtttagag     1140

tcagatatcc gtactgagga atcatgaaca cgtccgcagg gaacggaggg aggcagccct     1200

ggtgcgcaga gccgaggacg tacggcagtt ggtactccga gtccgagaag acctgaatcg     1260

tgctggtaag gttattagcg atggtcgtaa cgccgtcgtt cgtcgtgacc tccttgacct     1320

ggatgttgaa caacttgaac cgcagctttc tgggccggaa tccccagttg ttgttgatga     1380

gtcgctgcca gtcacgtggt gagaagtggc agtggaatct gttgaagtca aaatagcccc     1440

agggggtgct gtagctgaag aagtggttgt cgttggtagc cccgctctga cttgatatct     1500

gcttgtagag gtggttgttg taggtgggca gggcccaggt gcgggtgctg gtggtgatga     1560

ctctgtcgcc cagccatgtg gaatcgcaat gccaatttcc ggaggcatta cccactccgt     1620

cggcgccttc gttattgtct gccattggtg cgccaccgcc tgcagccatt gtaccagatc     1680

ccagacctga gggcgcggcg ggaggttctc cgagaggttg ggggtcgggc actgactctg     1740

agtcgccagt ctgcccaaag ttgagcttct ttttagcggg ctgctggcct ttcttgccga     1800

tgcccgtgga ggagtcgggg gattctatgg gtctcttctt tccaggagcc gtcttagcga     1860

cttcctcaac cagaccgaga ggttcgagaa cccgcttctt ggcctggaag actgctcgcc     1920

cgaggttgcc cccaaaagac gtatcttctt gaagacgctc ctgaaactcg gcgtcggcgt     1980

ggttgtactt gaggtacggg ttgtccccct gctcgagctg cttgtcgtag gccttgtcgt     2040

gctcgagggc cgcggcgtct gcctcgttga ccggctctcc cttgtcgagt ccgttgaagg     2100

gtctgaggta cttgtagcca ggaagcacca gaccccggcc gtcgtcctgc ttttgctggt     2160

tggctttggg tttcggggct ccaggtttca agtcccacca ctcgcgaatg ccctcagaga     2220

ggttgtcctc gagccaatct ggaagataac catcggcagc catacctggt ttaagtcatt     2280

tattgctcag aaacacagtc atccaggtcc acgttgacca gatcgcaggc cgagcaagca     2340

atctcgggag cccgccccag cagatgatga atggcacaga gtttccgata cgtcctcttt     2400

ctgacgaccg gttgagattc tgacacgccg gggaaacatt ctgaacagtc tctggtcccg     2460

tgcgtgaagc aaatgttgaa attctgattc actctctcgc atgtcttgca gggaaacagc     2520

atctgaagca tgcccgcgtg acgagaacat ttgttttggt acctgtcggc aaagtccacc     2580

ggagctcctt ccgcgtctga cgtcgatgga ttcgcgactg aggggcaggc ccgcttgggc     2640

tcgcttttat ccgcgtcatc gggggcgggt ctcttgttgg ccccaccctt tctgacgtag     2700

aacccatgcg ccacctcggt cacgtgatcc tgcgcccagc ggaagaacct tttgacttcc     2760

tgctttgtca ccttgccaaa gttatgctcc agacggcggg tgggttcaaa tttgaacatc     2820

cggtcctgca acggctgctg gtgctcgaag gtggcgctgt tcccgtcaat cacggcgcac     2880

atgttggtgt tggaggtgac ggtcacgggg gtggggtcga tctgggcgga cgacttgcac     2940

ttttggtcca cgcgcacctt gctgccgccg agaatggcct tggcggactc cacgaccttg     3000

gccgtcatct tgccctcctc ccaccagatc accatcttgt cggcgcaatc gttgaaggga     3060

aagttctcat tggtccagtt gacgcagccg tagaaagggc gaattc                    3106


<210> 4821
<211> 3102
<212> DNA
<213> Adeno-associated virus

<400> 4821
gcggccgcga attcgccctt cgcagagacc aaagttcaac tgaaacgaat caaccggttt       60

attgattaac aagtaattac aggttacggg tgaggtaacg ggtgccaatg gggcgaggct      120

cagtataaac cccttcgttg ttgacagcaa attccacatt attagacttg gcataatttg      180

aggtgtactg aatctctgga ttccagcgtt tgctgttttc tttctgcagt tcccactcga      240

tctccacgct gacctggccg gtgctgtact gcgtgataaa tgaggcaaac ttggcaggag      300

taaacacctc tggaggatta gcaggtaccg gggtgttttt gatgagaatt tgaggaggcg      360

ggtgtttgag tccaaatccg cccatcaggg gagacgggtg aaagttgccg tccgtgtgag      420

gaatttcggc ccagatggga ccctgcaggt acacgtcccg gttctgccag accatgccgg      480

gcagagcccc ctggctgttg acagtctgtg tccggggtcc ggccgtagac gattgcaggt      540

tgctggagac cacaccgtat tcttctgtag ccacgggatt ggtggttttg atctcctcct      600

cgctggtcat tagcacgttt tccagcgttg tcttgttggc agcccccgtt ttgccaaaaa      660

ccagcactcc gttgatggga aggaactggt cctcgtcgtc cttgttggtg gccatggcta      720

cgcccgggtt ggttaatgaa tttctaccat tcagatggta tttagtggcc ccggtccagg      780

caaagttact gttgttgttg ctgtctatgt tttttgacag tctctgctgc cgataacagg      840

gtccgggcag ccagttcttt gattgctcgg ccacggtgtt gggcccagcc tgatggaact      900

gcagctccct tgtggacccc gtagtgctct gggtccgggc caggtagtac aggtactggt      960

cgatgagggg attcatcagc cggtccaggc tctggctgtg cgcatagctg ctgtggaaag     1020

gcacttcctc aaaggtgtag ctgaattcaa agttattgcc cgttctcagc atctgagaag     1080

gaaagtactc caggcagcag aaggaggaac gtcccacaga ctgactgccg ttgtttagag     1140

tcagatatcc gtactgagga atcatgaaca cgtccgcagg gaacggaggg aggcagccct     1200

ggtgcgcaga gccgaggacg tacggcagtt ggtactccga gtccgagaag acctgaatcg     1260

tgctggtaag gttattagcg atggtcgtaa cgccgtcgtt cgtcgtgacc tccttgacct     1320

ggatgttgaa caacttgaac cgcagctttc tgggccggaa tccccagttg ttgttgatga     1380

gtcgctgcca gtcacgtggt gagaagtggc agtggaatct gttgaagtca aaatagcccc     1440

agggggtgct gtagccgaag aagtggttgt cgttggtagc cccgctctga cttgatatct     1500

gcttgtagag gtggttgttg taggtgggca gggcccaggt gcgggtgctg gtggtgatga     1560

ctctgtcgcc cagccatgtg gaatcgcaat gccaatttcc ggaggcatta cccactccgt     1620

cggcgccttc gttattgtct gccattggtg cgccaccgcc tgcagccatt gtaccagatc     1680

ccagacctga gggcgcggcg ggaggttctc cgagaggttg ggggtcgggc actgactctg     1740

agtcgccagt ctgcccaaag ttgagcttct ttttagcggg ctgctggcct ttcttgccga     1800

tgcccgtgga ggagtcgggg gattctatgg gtctcttctt tccggaagcc gtcttagcgc     1860

cttcctcaac cagaccgaga ggttcgagaa cccgcttctt ggcctggaag actgctcgcc     1920

cgaggttgcc cccaaaagac gtatcttctt gaagacgctc ctgaaactcg gcgtcggcgt     1980

ggttgtactt gaggtacggg ttgtccccct gctcgagctg cttgtcgtag gccttgtcgt     2040

gctcgagggc cgcggcgtct gcctcgttga ccggctctcc cttgtcgagt ccgttgaagg     2100

gtccgaggta cttgtagcca ggaagcacca gaccccggcc gtcgtcctgc ttttgctggt     2160

tggctttggg tttcggggct ccaggtttca agtcccacca ctcgcgaatg ccctcagaga     2220

ggttgtcctc gagccaatct ggaagataac catcggcagc catacctggt ttaagtcatt     2280

tattgctcag aaacacagtc atccaggtcc acgttgacca gatcgcaggc cgagcaagca     2340

atctcgggag cccgccccag cagatgatga atggcacaga gtttccgata cgtcctcttt     2400

ctgacgaccg gttgagattc tgacacgccg gggaaacatt ctgaacagtc tctggtcccg     2460

tgcgtgaagc aaatgttgaa attctgattc attctctcgc atgtcttgca gggaaacagc     2520

atctgaagca tgcccgcgtg acgagaacat ttgttttggt acctgtcggc aaagtccacc     2580

ggagctcctt ccgcgtctga cgtcgatgga tccgcgactg aggggcaagc ccgcttgggc     2640

tcgcttttat ccgcgtcatc gggggcgggt ctcttgttgg ctccaccctt tctgacgtag     2700

aactcatgcg ccacctcggt cacgtgatcc tgcgcccagc ggaagaactc tttgacttcc     2760

tgctttgtca ccttgccaaa gtcatgctcc agacggcggg tgagttcaaa tttgaacatc     2820

cggtcttgta acggctgctg gtgctcgaag gtggtgctgt tcccgtcaat cacggcgcac     2880

atgttggtgt tggaagtgac gatcacgggg gtgggatcga tctgggcgga cgacttgcac     2940

ttttggtcca cgcgcacctt gctgccgccg agaatggcct tggcggactc cacgaccttg     3000

gccgtcatct tgccctcctc ccaccagatc accatcttgt cgacgcaatc gttgaaggga     3060

aagttctcat tggtccagtt gacgcagccg aagggcgaat tc                        3102


<210> 4822
<211> 728
<212> PRT
<213> Adeno-associated virus

<400> 4822
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Arg Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Asn Gly Gln 
145                 150                 155                 160 


Pro Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210> 4823
<211> 2187
<212> DNA
<213> Adeno-associated virus

<400> 4823
atggctgccg atggttatct tccagattgg ctcgagggca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aggtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

aagcagctcg agcaggggga caacccgtac ctcaagtaca accacgccga cgccgagttt      300

caggagcgtc ttcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gacccataga atcccccgac tcctccacgg gcatcggcaa gaacggccag      480

ccgcccgcta aaaagaagct caactttggg cagactggcg actcagagtc agtgcccgac      540

ccccaacctc tcggagaacc tcccgccgcg ccctcaggtc tgggatctgg tacaatggct      600

gcaggcggtg gcgcaccaat ggcagacaat aacgaaggcg ccgacggagt gggtaatgcc      660

tccggaaatt ggcattgcga ttccacatgg ctgggcgaca gagtcatcac caccagcacc      720

cgcacctggg ccctgcccac ctacaacaac cacctctaca agcagatatc aagtcagagc      780

ggggctacca acgacaacca cttcttcggc tacagcaccc cctggggcta ttttgacttc      840

aacagattcc actgccactt ctcaccacgt gactggcagc gactcatcaa caacaactgg      900

ggattccggc ccagaaagct gcggttcaag ttgttcaaca tccaggtcaa ggaggtcacg      960

acgaacgacg gcgttacgac catcgctaat aaccttacca gcacgattca ggtcttctcg     1020

gactcggagt accaactgcc gtacgtcctc ggctctgcgc accagggctg cctccctccg     1080

ttccctgcgg acgtgttcat gattcctcag tacggatatc tgactctaaa caacggcagt     1140

cagtctgtgg gacgttcctc cttctactgc ctggagtact ttccttctca gatgctgaga     1200

acgggcgata actttgaatt cagctacacc tttgaggaag tgcctttcca cagcagctat     1260

gcgcacagcc agagcctgga ccggctgatg aatcccctca tcgaccagta cctgtactac     1320

ctggcccgga cccagagcac tacggggtcc acaagggagc tgcagttcca tcaggctggg     1380

cccaacacca tggccgagca atcaaagaac tggctgcccg gaccctgtta tcggcagcag     1440

agactgtcaa aaaacataga cagcaacaac aacagtaact ttgcctggac cggggccact     1500

aaataccatc tgaatggtag aaattcatta accaacccgg gcgtagccat ggccaccaac     1560

aaggacgacg aggaccagtt ctttcccatc aacggagtgc tggtttttgg caaaacgggg     1620

gctgccaaca agacaacgct ggaaaacgtg ctaatgacca gcgaggagga gatcaaaacc     1680

accaatcccg tggctacaga agaatacggt gtggtctcca gcaacctgca atcgtctacg     1740

gccggacccc agacacagac tgtcaacagc cagggggctc tgcccggcat ggtctggcag     1800

aaccgggacg tgtacctgca gggtcccatc tgggccaaaa ttcctcacac ggacggcaac     1860

tttcacccgt ctcccctgat gggcggattt ggactcaaac acccgcctcc tcaaattctc     1920

atcaaaaaca ccccggtacc tgctaatcct ccagaggtgt ttactcctgc caagtttgcc     1980

tcatttatca cgcagtacag caccggccag gtcagcgtgg agatcgagtg ggaactgcag     2040

aaagaaaaca gcaaacgctg gaatccagag attcagtaca cctcaaatta tgccaagtct     2100

aataatgtgg aatttgctgt caacaacgaa ggggtttata ctgagcctcg ccccattggc     2160

acccgttacc tcacccgtaa cctgtaa                                         2187


<210> 4824
<211> 728
<212> PRT
<213> Adeno-associated virus

<400> 4824
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Gly Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Arg Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Asn Gly Gln 
145                 150                 155                 160 


Pro Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asp Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210> 4825
<211> 3106
<212> DNA
<213> Adeno-associated virus

<400> 4825
gcggccgcga attcgccctt cgcagagacc aaagttcaac tgaaacgaat cagccggttt       60

attgattaac aagtaattac aggttacggg tgaggtaacg ggtgccaatg gggcgaggct      120

cagtataaac cccttcgttg ttgacagcaa attccacatt attagacttg gcataatttg      180

aggtgtactg aatctctgga ttccagcgtt tgctgttttc tttctgcagt tcccactcga      240

tctccacgct gacctggccg gtgctgtact gcgtgataaa tgaggcaaac ttggcaggag      300

taaacacctc tggaggatta gcaggtaccg gggtgttttt gatgagaatt tgaggaggcg      360

ggtgtttgag tccaaatccg cccatcaggg gagacgggtg aaagttgccg tccgtgtgag      420

gaattttggc ccagatggga ccctgcaggt acacgtcccg gttctgccag accatgccgg      480

gcagagcccc ctggctgttg acagtctgtg tctggggtcc ggccgtagac gattgcaggt      540

tgctggagac cacaccgtat tcttctgtag ccacgggatt ggtggttttg atctcctcct      600

cgctggtcat tagcacgttt tccagcgttg tcttgttggc agcccccgtt ttgccaaaaa      660

ccagcactcc gttgatggga aagaactggt cctcgtcgtc cttgttggtg gccatggcta      720

cgcccgggtt ggttaatgaa tttctaccat tcagatggta tttagtggcc ccggtccagg      780

caaagttact gttgttgttg ctgtctatgt tttttgacag tctctgctgc cgataacagg      840

gtccgggcag ccagttcttt gattgctcgg ccatggtgtt gggcccagcc tgatggaact      900

gcagctccct tgtggacccc gtagtgctct gggtccgggc caggtagtac aggtactggt      960

cgatgagggg attcatcagc cggtccaggc tctggctgtg cgcatagctg ctgtggaaag     1020

gcacttcctc aaaggtgtag ctgaattcaa agttatcgcc cgttctcagc atctgagaag     1080

gaaagtactc caggcagtag aaggaggaac gtcccacaga ctgactgccg ttgtttagag     1140

tcagatatcc gtactgagga atcatgaaca cgtccgcagg gaacggaggg aggcagccct     1200

ggtgcgcaga gccgaggacg tacggcagtt ggtactccga gtccgagaag acctgaatcg     1260

tgctggtaag gttattagcg atggtcgtaa cgccgtcgtt cgtcgtgacc tccttgacct     1320

ggatgttgaa caacttgaac cgcagctttc tgggccggaa tccccagttg ttgttgatga     1380

gtcgctgcca gtcacgtggt gagaagtggc agtggaatct gttgaagtca aaatagcccc     1440

agggggtgct gtagccgaag aagtggttgt cgttggtagc cccgctctga cttgatatct     1500

gcttgtagag gtggttgttg taggtgggca gggcccaggt gcgggtgctg gtggtgatga     1560

ctctgtcgcc cagccatgtg gaatcgcaat gccaatttcc ggaggcatta cccactccgt     1620

cggcgccttc gttattgtct gccattggtg cgccaccgcc tgcagccatt gtaccagatc     1680

ccagacctga gggcgcggcg ggaggttctc cgagaggttg ggggtcgggc actgactctg     1740

agtcgccagt ctgcccaaag ttgagcttct ttttagcggg cggctggccg ttcttgccga     1800

tgcccgtgga ggagtcgggg gattctatgg gtctcttctt tccaggagcc gtcttagcgc     1860

cttcctcaac cagaccgaga ggttcgagaa cccgcttctt ggcctggaag actgctcgcc     1920

cgaggttgcc cccaaaagac gtatcttctt gaagacgctc ctgaaactcg gcgtcggcgt     1980

ggttgtactt gaggtacggg ttgtccccct gctcgagctg cttgtcgtag gccttgtcgt     2040

gctcgagggc cgcggcgtct gcctcgttga ccggctctcc cttgtcgagt ccgttgaagg     2100

gtccgaggta cctgtagcca ggaagcacca gaccccggcc gtcgtcctgc ttttgctggt     2160

tggctttggg tttcggggct ccaggtttca agtcccacca ctcgcgaatg ccctcagaga     2220

ggttgccctc gagccaatct ggaagataac catcggcagc catacctggt ttaagtcatt     2280

tattgctcag aaacacagtc atccaggtcc acgttggcca gatcgcaggc cgagcaagca     2340

atctcgggag cccgccccag cagatgatga atggcacaga gtttccgata cgtcctcttt     2400

ctgacgaccg gttgagattc tgacacgccg gggaaacatt ctgaacagtc tctggtcccg     2460

tgcgtgaagc aaatgttgaa attctgattc attctctcgc atgtcttgca ggggaacagc     2520

atctgaagca tgcccgcgtg acgagaacat ttgttttggt acctgtcggc aaagtccacc     2580

ggagctcctt ccgcgtctga cgtcgatgga tccgcgactg aggggcaggc ccgcttgggc     2640

tcgcttttat ccgcgtcatc gggggcgggt ctcttgttgg ctccaccctt tctgacgtag     2700

aactcatacg ccacctcggt cacgtgatcc tgcgcccagc ggaagaactc tttgacttcc     2760

tgctttgtca ccttgccaaa gtcatgctcc agacggcggg tgagttcaaa tttgaacatc     2820

cggtcttgta acggctgctg gtgctcgaag gtggtgctgt tcccgtcaat cacggcgcac     2880

atgttggtgt tggaagtgac gatcacgggg gtgggatcga tctgggcgga cgacttgcac     2940

ttttggtcca cgcgcacctt gctgccgccg agaatggcct tggcggactc cacgaccttg     3000

gccgtcatcc tgccctcctc ccaccagatc accatcttgt cgacgcaatc gttgaaggga     3060

aagttctcat tggtccagtt gacgcagccg tagaaagggc gaattc                    3106


<210> 4826
<211> 728
<212> PRT
<213> Adeno-associated virus

<400> 4826
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Arg Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Asn Gly Gln 
145                 150                 155                 160 


Pro Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asp Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210> 4827
<211> 728
<212> PRT
<213> Adeno-associated virus

<400> 4827
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Arg Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Asn Gly Gln 
145                 150                 155                 160 


Pro Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210> 4828
<211> 728
<212> PRT
<213> Adeno-associated virus

<400> 4828
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Asn Gly Gln 
145                 150                 155                 160 


Pro Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210> 4829
<211> 728
<212> PRT
<213> Adeno-associated virus

<400> 4829
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210> 4830
<211> 3098
<212> DNA
<213> Adeno-associated virus

<400> 4830
gaattcgccc ttcgcagaga ccaaagttca actgaaacga atcaaccggt ttattgatta       60

acaagtaatt acaggttacg ggtgaggtaa cgggtgccaa tggggcgagg ctcagtataa      120

accccttcgt tgttgacagc aaattccaca ttattagact tggcataatt tgaggtgtac      180

tgaatctctg gattccagcg tttgctgttt tctttctgca gttcccactc gatctccacg      240

ctgacctggc cggtgctgta ctgcgtgata aatgaggcaa actaggcagg agtaaacacc      300

cctggaggat tagcaggtac cggggtgttt ttgatgagaa tttgaggagg cgggtgtttg      360

agtccaaatc cgcccatcag gggagacggg tgaaagttgc cgtccgtgtg aggaattttg      420

gcccagatgg gaccctgcag gtacacgtcc cggttctgcc agaccatgcc gggcagagcc      480

ccctggctgt tgacagtctg tgtctggggt ccggccgtag acgattgcag gttgctggag      540

accacaccgt attcttctgt agccacggga ttggtggttt tgatctcctc ctcgctggtc      600

attagcacgt tttccagcgt tgtcttgttg gcagcccccg ttttgccaaa aaccagcact      660

ccgttgatgg gaaagaactg gccctcgtcg tccttgttgg tggccatggc tacgcccggg      720

ttggttaatg aatttctacc attcagatgg tatttagtgg ccccggtcca ggcaaagtta      780

ctgttgttgt tgctgtctat gttttttgac agtctctgct gccgataaca gggtccgggc      840

agccagttct ttgattgctc ggccatggtg ttgggcccag cctgatggaa ctgcagctcc      900

cttgtggacc ccgtagtgct ctgggtccgg gccaggtagt acaggtactg gtcgatgagg      960

ggattcatca gccggtccag gctctggctg tgcgcatagc tgctgtggaa aggcacttcc     1020

tcaaaggtgt agctgaattc aaagttattg cccgttctca gcatctgaga aggaaagtac     1080

tccaggcagt agaaggagga acgtcccata gactgactgc cgttgtttag agtcagatat     1140

ccgtactgag gaatcatgaa cacgtccgca gggaacggag ggaggcagcc ctggtgcgca     1200

gagccgagga cgtacggcag ttggtactcc gagtccgaga agacctgaat cgtgctggta     1260

aggttattag cgatggtcgt aacgccgtcg ttcgtcgtga cctccttgac ctggatgttg     1320

aacaacttga accgcagctt tctgggccgg aatccccagt tgttgttgat gagtcgctgc     1380

cagtcacgtg gtgagaagtg gcagtggaat ctgttgaagt caaaatagcc ccagggggtg     1440

ctgtagccga agaagtggtt gtcgttggta gccccgctct gacttgatat ctgcttgtag     1500

aggtggttgt tgtaggtggg cagggcccag gtgcgggtgc tggtggtgat gactctgtcg     1560

cccagccatg tggaatcgca atgccaattt ccggaggcat tacccactcc gtcggcgcct     1620

tcgttattgt ctgccattgg tgcgccaccg cctgcagcca ttgtaccaga tcccagacct     1680

gagggcgcgg cgggaggttc tccgagaggt tgggggtcgg gcactgactc tgagtcgcca     1740

gtctgcccaa agttgagctt ctttttagcg ggctgctggc ctttcttgcc gatgcccgtg     1800

gaggagtcgg gggattctat gggtctcttc tttccaggag ccgtcttagc gccttcctca     1860

accagaccga gaggttcgag aacccgcttc ttggcctgga agactgctcg cccgaggttg     1920

cccccaaaag acgtatcttc ttgaagacgc tcctgaaact cagcgtcggc gtggttgtac     1980

ttgaggtacg ggttgtcccc ctgctcgagc tgcttgtcgt aggccttgtc gtgctcgagg     2040

gccgcggcgt ctgcctcgtt gaccggctct cccttgtcga gtccgttgaa gggtccgagg     2100

tacttgtagc caggaagcac cagaccccgg ccgtcgtcct gcttttgctg gttggctttg     2160

ggtttcgggg ctccaggttt caagtcccac cactcgcgaa tgccctcaga gaggttgtcc     2220

tcgagccaat ctggaagata accatcggca gccatacctg gtttaagtca tttattgctc     2280

agaaacacag tcatccaggt ccacgttgac cagatcgcag gccgagcaag caatctcggg     2340

agcccgcccc agcagatgat gaatggcaca gagtttccga tacgtcctct ttctgacgac     2400

cggttgagat tctgacacgc cggggaaaca ttctgaacag tctctggtcc cgtgcgtgaa     2460

gcaaatgttg aaattctgat tcattctctc gcatgtcttg cagggaaaca gcatctgaag     2520

catgcccgcg tgacgagaac atttgttttg gtacctgtcg gcaaagtcca ccggagctcc     2580

ttccgcgtct gacgtcgatg gatccgcgac tgaggggcag gcccgcttgg gctcgctttt     2640

atccgcgtca tcgggggcgg gcctcttgtt ggctccaccc tttctgacgt agaactcatg     2700

cgccacctcg gtcacgtgat cctgcgccca gcggaagaac tctttgactt cctgctttgt     2760

caccttgcca aagtcctgct ccagacggcg ggtgagttca aatttgaaca tccggtcttg     2820

taacggctgc tggtgctcga aggtggtgct gttcccgtca atcacggcgc acatgttggt     2880

gttggaagtg acgatcacgg gggtgggatc gatctgggcg gacgacttgc acttttggtc     2940

cacgcgcacc ttgctgccgc cgagaatggc cttggcggac tccacgacct tggccgtcat     3000

cttgccctcc tcccaccaga tcaccatctt gtcgacgcaa tcgttgaagg gaaagttctc     3060

attggtccag ttgacgcagc cgtagaaagg gcgaattc                             3098


<210> 4831
<211> 729
<212> PRT
<213> Adeno-associated virus

<400> 4831
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Asp Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Ser Ser Ser Gly Ala Thr Asn Asp Asn His Tyr Phe Gly Tyr 
            260                 265                 270         


Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe 
        275                 280                 285             


Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg 
    290                 295                 300                 


Pro Lys Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val 
305                 310                 315                 320 


Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr 
                325                 330                 335     


Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly 
            340                 345                 350         


Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met 
        355                 360                 365             


Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val 
    370                 375                 380                 


Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu 
385                 390                 395                 400 


Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Ser Phe Glu Asp Val Pro 
                405                 410                 415     


Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn 
            420                 425                 430         


Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr 
        435                 440                 445             


Thr Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr 
    450                 455                 460                 


Met Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln 
465                 470                 475                 480 


Gln Gly Leu Ser Lys Asn Leu Asp Phe Asn Asn Asn Ser Asn Phe Ala 
                485                 490                 495     


Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr 
            500                 505                 510         


Asn Pro Gly Ile Pro Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe 
        515                 520                 525             


Phe Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn 
    530                 535                 540                 


Lys Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys 
545                 550                 555                 560 


Thr Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn 
                565                 570                 575     


Leu Gln Pro Ser Thr Ala Gly Pro Gln Ser Gln Thr Ile Asn Ser Gln 
            580                 585                 590         


Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln 
        595                 600                 605             


Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro 
    610                 615                 620                 


Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile 
625                 630                 635                 640 


Leu Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr 
                645                 650                 655     


Pro Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val 
            660                 665                 670         


Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp 
        675                 680                 685             


Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val 
    690                 695                 700                 


Glu Phe Ala Val Asn Pro Asp Gly Val Tyr Thr Glu Pro Arg Pro Ile 
705                 710                 715                 720 


Gly Thr Arg Tyr Leu Pro Arg Asn Leu 
                725                 


<210> 4832
<211> 1458
<212> PRT
<213> Adeno-associated virus

<400> 4832
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Asp Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Thr Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Ser Ser Ser Gly Ala Thr Asn Asp Asn His Tyr Phe Gly Tyr 
            260                 265                 270         


Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe 
        275                 280                 285             


Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg 
    290                 295                 300                 


Pro Lys Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val 
305                 310                 315                 320 


Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr 
                325                 330                 335     


Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly 
            340                 345                 350         


Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met 
        355                 360                 365             


Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val 
    370                 375                 380                 


Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu 
385                 390                 395                 400 


Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Ser Phe Glu Asp Val Pro 
                405                 410                 415     


Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn 
            420                 425                 430         


Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr 
        435                 440                 445             


Thr Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr 
    450                 455                 460                 


Met Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln 
465                 470                 475                 480 


Gln Arg Leu Ser Lys Asn Leu Asp Phe Asn Asn Asn Ser Asn Phe Ala 
                485                 490                 495     


Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr 
            500                 505                 510         


Asn Pro Gly Ile Pro Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe 
        515                 520                 525             


Phe Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn 
    530                 535                 540                 


Lys Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys 
545                 550                 555                 560 


Thr Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn 
                565                 570                 575     


Leu Gln Ser Ser Thr Ala Gly Pro Gln Ser Gln Thr Ile Asn Ser Gln 
            580                 585                 590         


Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln 
        595                 600                 605             


Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro 
    610                 615                 620                 


Ser Pro Leu Met Gly Gly Phe Gly Leu Glu His Pro Pro Pro Gln Ile 
625                 630                 635                 640 


Leu Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr 
                645                 650                 655     


Pro Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val 
            660                 665                 670         


Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp 
        675                 680                 685             


Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val 
    690                 695                 700                 


Glu Phe Ala Val Asn Pro Asp Gly Val Tyr Thr Glu Pro Arg Pro Ile 
705                 710                 715                 720 


Gly Thr Arg Tyr Leu Thr Arg Asn Leu Met Ala Ala Asp Gly Tyr Leu 
                725                 730                 735     


Pro Asp Trp Leu Glu Asp Asn Leu Ser Glu Gly Ile Arg Glu Trp Trp 
            740                 745                 750         


Asp Leu Lys Pro Gly Ala Pro Lys Pro Lys Ala Asn Gln Gln Lys Gln 
        755                 760                 765             


Asp Asp Gly Arg Gly Leu Val Leu Pro Gly Tyr Lys Tyr Leu Gly Pro 
    770                 775                 780                 


Phe Asn Gly Leu Asp Lys Gly Glu Pro Val Asn Ala Ala Asp Ala Ala 
785                 790                 795                 800 


Ala Leu Glu His Asp Lys Ala Tyr Asp Gln Gln Leu Lys Ala Gly Asp 
                805                 810                 815     


Asn Pro Tyr Leu Arg Tyr Asn His Ala Asp Ala Glu Phe Gln Glu Arg 
            820                 825                 830         


Leu Gln Glu Asp Thr Ser Phe Gly Gly Asn Leu Gly Arg Ala Val Phe 
        835                 840                 845             


Gln Ala Lys Lys Arg Val Leu Glu Pro Leu Gly Leu Val Glu Glu Gly 
    850                 855                 860                 


Ala Lys Thr Ala Pro Gly Lys Lys Arg Pro Ile Gly Ser Pro Asp Ser 
865                 870                 875                 880 


Ser Thr Gly Ile Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Lys Leu 
                885                 890                 895     


Asn Phe Gly Gln Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro 
            900                 905                 910         


Leu Gly Glu Pro Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met 
        915                 920                 925             


Ala Ala Gly Gly Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp 
    930                 935                 940                 


Gly Val Gly Asn Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu 
945                 950                 955                 960 


Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr 
                965                 970                 975     


Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Ser Ser Ser Ser Gly Ala 
            980                 985                 990         


Thr Asn Asp Asn His Tyr Phe Gly  Tyr Ser Thr Pro Trp  Gly Tyr Phe 
        995                 1000                 1005             


Asp Phe  Asn Arg Phe His Cys  His Phe Ser Pro Arg  Asp Trp Gln 
    1010                 1015                 1020             


Arg Leu  Ile Asn Asn Asn Trp  Gly Phe Arg Pro Lys  Lys Leu Arg 
    1025                 1030                 1035             


Phe Lys  Leu Leu Asn Ile Gln  Val Lys Glu Val Thr  Thr Asn Asp 
    1040                 1045                 1050             


Gly Val  Thr Thr Ile Ala Asn  Asn Leu Thr Ser Thr  Val Gln Val 
    1055                 1060                 1065             


Phe Ser  Asp Ser Glu Tyr Gln  Leu Pro Tyr Val Leu  Gly Ser Ala 
    1070                 1075                 1080             


His Gln  Gly Cys Leu Pro Pro  Phe Pro Ala Asp Val  Phe Met Ile 
    1085                 1090                 1095             


Pro Gln  Tyr Gly Tyr Leu Thr  Leu Asp Asn Gly Ser  Gln Ser Val 
    1100                 1105                 1110             


Gly Arg  Ser Ser Phe Tyr Cys  Leu Glu Tyr Phe Pro  Ser Gln Met 
    1115                 1120                 1125             


Leu Arg  Thr Gly Asn Asn Phe  Glu Phe Ser Tyr Ser  Phe Glu Asp 
    1130                 1135                 1140             


Val Pro  Phe His Ser Ser Tyr  Ala His Ser Gln Ser  Leu Asp Arg 
    1145                 1150                 1155             


Leu Met  Asn Pro Leu Ile Asp  Gln Tyr Leu Tyr Tyr  Leu Ala Arg 
    1160                 1165                 1170             


Thr Gln  Ser Thr Thr Gly Ser  Thr Arg Glu Leu Gln  Phe His Gln 
    1175                 1180                 1185             


Ala Gly  Pro Asn Thr Met Ala  Glu Gln Ser Lys Asn  Trp Leu Pro 
    1190                 1195                 1200             


Gly Pro  Cys Tyr Arg Gln Gln  Arg Leu Ser Lys Asn  Leu Asp Phe 
    1205                 1210                 1215             


Asn Asn  Asn Ser Asn Phe Ala  Trp Thr Ala Ala Thr  Lys Tyr His 
    1220                 1225                 1230             


Leu Asn  Gly Arg Asn Ser Leu  Thr Asn Pro Gly Ile  Pro Met Ala 
    1235                 1240                 1245             


Thr Asn  Lys Asp Asp Glu Asp  Gln Phe Phe Pro Ile  Asn Gly Val 
    1250                 1255                 1260             


Leu Val  Phe Gly Lys Thr Gly  Ala Ala Asn Lys Thr  Thr Leu Glu 
    1265                 1270                 1275             


Asn Val  Leu Met Thr Ser Glu  Glu Glu Ile Lys Thr  Thr Asn Pro 
    1280                 1285                 1290             


Val Ala  Thr Glu Glu Tyr Gly  Val Val Ser Ser Asn  Leu Gln Ser 
    1295                 1300                 1305             


Ser Thr  Ala Gly Pro Gln Ser  Gln Thr Ile Asn Ser  Gln Gly Ala 
    1310                 1315                 1320             


Leu Pro  Gly Met Val Trp Gln  Asn Arg Asp Val Tyr  Leu Gln Gly 
    1325                 1330                 1335             


Pro Ile  Trp Ala Lys Ile Pro  His Thr Asp Gly Asn  Phe His Pro 
    1340                 1345                 1350             


Ser Pro  Leu Met Gly Gly Phe  Gly Leu Lys His Pro  Pro Pro Gln 
    1355                 1360                 1365             


Ile Leu  Ile Lys Asn Thr Pro  Val Pro Ala Asn Pro  Pro Glu Val 
    1370                 1375                 1380             


Phe Thr  Pro Ala Lys Phe Ala  Ser Phe Ile Thr Gln  Tyr Ser Thr 
    1385                 1390                 1395             


Gly Gln  Val Ser Val Glu Ile  Glu Trp Glu Leu Gln  Lys Glu Asn 
    1400                 1405                 1410             


Ser Lys  Arg Trp Asn Pro Glu  Ile Gln Tyr Thr Ser  Asn Tyr Ala 
    1415                 1420                 1425             


Lys Ser  Asn Asn Val Glu Phe  Ala Val Asn Pro Asp  Gly Val Tyr 
    1430                 1435                 1440             


Thr Glu  Pro Arg Pro Ile Gly  Thr Arg Tyr Leu Thr  Arg Asn Leu 
    1445                 1450                 1455             


<210> 4833
<211> 729
<212> PRT
<213> Adeno-associated virus

<400> 4833
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Asp Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Thr Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Ser Ser Ser Gly Ala Thr Asn Asp Asn His Tyr Phe Gly Tyr 
            260                 265                 270         


Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe 
        275                 280                 285             


Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg 
    290                 295                 300                 


Pro Lys Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val 
305                 310                 315                 320 


Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr 
                325                 330                 335     


Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly 
            340                 345                 350         


Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met 
        355                 360                 365             


Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val 
    370                 375                 380                 


Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu 
385                 390                 395                 400 


Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Ser Phe Glu Asp Val Pro 
                405                 410                 415     


Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn 
            420                 425                 430         


Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr 
        435                 440                 445             


Thr Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr 
    450                 455                 460                 


Met Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln 
465                 470                 475                 480 


Gln Arg Leu Ser Lys Asn Leu Asp Phe Asn Asn Asn Ser Asn Phe Ala 
                485                 490                 495     


Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr 
            500                 505                 510         


Asn Pro Gly Ile Pro Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe 
        515                 520                 525             


Phe Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn 
    530                 535                 540                 


Lys Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys 
545                 550                 555                 560 


Thr Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn 
                565                 570                 575     


Leu Gln Ser Ser Thr Ala Gly Pro Gln Ser Gln Thr Ile Asn Ser Gln 
            580                 585                 590         


Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln 
        595                 600                 605             


Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro 
    610                 615                 620                 


Ser Pro Leu Met Gly Gly Phe Gly Leu Glu His Pro Pro Pro Gln Ile 
625                 630                 635                 640 


Leu Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr 
                645                 650                 655     


Pro Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val 
            660                 665                 670         


Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp 
        675                 680                 685             


Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val 
    690                 695                 700                 


Glu Phe Ala Val Asn Pro Asp Gly Val Tyr Thr Glu Pro Arg Pro Ile 
705                 710                 715                 720 


Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 


<210> 4834
<211> 3075
<212> DNA
<213> Adeno-associated virus

<400> 4834
tgagaacttt cctttcaacg attgcgtcgg acaagatggt gatctggtgg gaggagggga       60

agatgaccgc caaggtcgtg gagtcggcca aagccattct tggaggaagc aaggtgcgtg      120

tggaccagaa atgcaagtcc tcggcccaga tagacccgac tcccgtgatc gtcacctcca      180

acaccaacat gtgcgccgtg attgacggga actcaacgac cttcgagcac cagcagccgt      240

tgcaagaccg gatgttcaaa tttgaactta cccgccgtct ggatcatgac tttggaaagg      300

tcaccaagca ggaagtgaaa gactttttcc ggtgggcaaa ggatcacgtg gttgaggtgg      360

agcatgaatt ctacgtcaaa aagggtggag ctaagaaaag acccgccccc agtgacgcag      420

atataagtga gcccaaacgg gcgcgcgagt cagttgcgca gccatcaacg tcagacgcgg      480

aagcttcgat caactacgcg gacaggtacc aaaaacaaat gttctcgtca cgtgggcatg      540

aatctgatgc tgtttccctg cagacaatgc gagagaatga atcagaattc aaatatctgc      600

ttcactcacg gacagaaaga ctgtttagag tgctttcccg tgtcagaatc tcaacccgtt      660

tctgtcgtca aaaaggcgta tcagaaactg tgctacattc atcatatcat gggaaaggtg      720

ccagacgctt gcactgcctg cgatctggtc aatgtggatt tggatgactg catctctgaa      780

caataaatga tttaaatcag gtatggctgc cgatggttat cctccagatt ggctcgagga      840

cactctctct gaagggataa gacagtggtg gaagctcaaa cctggcccac caccaccaaa      900

gcccgcagag cggcataagg acgacagcag gggtcttgtg cttcctgggt acaagtacct      960

cggacccttc aacggactcg acaaggggga gccggtcaac gaggcagacg ccgcggccct     1020

cgagcacgac aaggcctacg accggcagct cgacagcgga gacaacccgt acctcaagta     1080

caaccacgcc gacgcagagt ttcaggagcg ccttaaagaa gatacgtctt ttgggggcaa     1140

cctcggacga gcagtcttcc aggcgaaaaa gagggttctt gaacctctgg gcctggttga     1200

ggaacctgtt aagacggctc cgggaaaaaa gaggccggta gagcactctc ctgtggagcc     1260

agactcctcc tcgggaaccg gaaaagcggg ccagcggcct gcaagaaaaa gattaaattt     1320

tggtcagact ggagacgcag actccgtacc tgacccccag cctctcggac agccaccagc     1380

agccccctct ggtctgggat ctactacaat ggctacaggc agtggcgcac caatggcaga     1440

caataacgag ggtgccgatg gagtgggtaa ttcctcagga aattggcatt gcgattccca     1500

atggctgggc gacagagtca tcaccaccag cacccgaacc tgggccctgc ccacatacaa     1560

caaccacctc tacaagcaaa tctccagcca atcaggagcc agcaacgaca accactactt     1620

tggctacagc accccctggg ggtattttga cttcaacaga ttccactgcc acttttcacc     1680

acgtgactgg caaagactca tcaacaacaa ctggggattc cggcccaaaa gactcaactt     1740

caagctcttt aatattcaag tcaaagaggt cacgcagaat gacggtacga cgacgattgc     1800

caataacctt accagcacgg ttcaggtgtt tactgactcg gagtaccagc tcccgtacgt     1860

cctgggctcg gcgcatcaag gatgcctccc gccgtttcca gcggacgtct tcatggtccc     1920

acagtatgga tacctcaccc tgaacaacgg gagtcaggcg gtaggacgct cttcctttta     1980

ctgcctggag tactttcctt ctcagatgct gcgtactgga aacaactttc agttcagcta     2040

cacttttgaa gacgtgcctt tccacagcag ctacgctcac agccagagtc tggatcggct     2100

gatgaatcct ctgatcgacc agtacctgta ttatctgaac aagacacaaa caaatagtgg     2160

aactcttcag cagtctcggc tactgtttag ccaagctgga ccaaccaaca tgtctcttca     2220

agctaaaaac tggctgcctg gaccttgcta cagacagcag cgtctgtcaa aacaggcaaa     2280

cgacaacaac aacagcaact ttccctggac tgcagctaca aagtatcatc taaatggccg     2340

ggactcgttg gttaatccag gaccagctat ggccagtcac aaggatgacg aagaaaagtt     2400

tttccccatg catggaaccc tgatatttgg taaacaagga acaaatgcca acgacgcgga     2460

tttggaaaat gtcatgatta cagatgaaga agaaatcagg gccaccaatc ccgtggctac     2520

ggagcagtac gggactgtgt caaataattt gcaaaactca aacactggtc caactactgg     2580

aactgtcaat cgccaaggag cgttacctgg tatggtgtgg caggatcgag acgtgtacct     2640

gcagggaccc atttgggcca agattcctca caccgatgga cactttcatc cttctccact     2700

gatgggaggt tttggactca aacacccgcc tcctcagatc atgatcaaaa acactcccgt     2760

tccagccaat cctcccacaa acttcagttc tgccaagttt gcttctttca tcacacagta     2820

ttccacggga caggtcagcg tggagatcga gtgggagctg cagaaggaga acagcaaacg     2880

ctggaatccc gaaattcagt acacttccaa ctacaacaag tctgttaatg tggactttac     2940

tgtggacact aatggtgtgt attcagagcc tcgccccatt ggcaccagat acctgactcg     3000

taatctgtaa ttgcttgtta atcaataaac cgtttaattc gtttcagttg aactttggtc     3060

tctgcgaagg gcgaa                                                      3075


<210> 4835
<211> 3142
<212> DNA
<213> Adeno-associated virus

<400> 4835
aaaacgacgg gccagtgatt gtaatacgac tcactatagg gcgaaattga aattagcggc       60

cgcgaattcg cctttcgcag agaccaaagt tcaactgaaa cgaattaaac ggtttattga      120

ttaacaagca attacagatt acgagtcagg tatctggtgc caatggggcg aggctctgaa      180

tacacaccat tagtgtccac agtaaagtcc acattaacag acttgttgta gttggaagtg      240

tactgaattt cgggattcca gcgtttgctg ttctccttct gcagctccca ctcgatctcc      300

acgctgacct gtcccgtgga atactgtgtg atgaaagaag caaacttggc agaactgaag      360

tttgtgggag gattggctgg aacgggagtg tttttgatca tgatctgagg aggcgggtgt      420

ttgagtccaa aacctcccat cagtggagaa ggatgaaagt gtccatcggt gtgaggaatc      480

ttggcccaaa tgggtccctg caggtacacg tctcgatcct gccacaccat accaggtaac      540

gctccttggt gattgacagt tccagtagtt ggaccagtgt ttgagttttg caaattattt      600

gacacagtcc cgtactgctc cgtagccacg ggattggtgg ccctgatttc ttcttcatct      660

gtaatcatga cattttccaa atccgcgtcg ttggcatttg ttccttgttt accaaatatc      720

agggttccat gcatggggaa aaacttttct tcgtcatcct tgtgactggc catagctggt      780

cctggattaa ccaacgagtc ccggccattt agatgatact ttgtagctgc agtccaggga      840

aagttgctgt tgttgttgtc gtttgcctgt tttgacagac gctgctgtct gtagcaaggt      900

ccaggcagcc agtttttagc ttgaagagac atgttggttg gtccagcttg gctaaacagt      960

agccgagact gctgaagagt tccactattt gtttgtgtct tgttcagata atacaggtac     1020

tggtcgatca gaggattcat cagccgatcc agactctggc tgtgagcgta gctgctgtgg     1080

aaaggcacgt cttcaaaagt gtagctgaac tgaaagttgt ttccagtacg cagcatctga     1140

gaaggaaagt actccaggca gtaaaaggaa gagcgtccta ccgcctgact cccgttgttc     1200

agggtgaggt atccatactg tgggaccatg aagacgtccg ctggaaacgg cgggaggcat     1260

ccttgatgcg ccgagcccag gacgtacggg agctggtact ccgagtcagt aaacacctga     1320

accgtgctgg taaggttatt ggcaatcgtc gtcgtaccgt cattctgcgt gacctctttg     1380

acttgaatat taaagagctt gaagttgagt cttttgggcc ggaatccccg gttgttgttg     1440

acgagtcttt gccagtcacg tggtgaaaag tggcagtgga atctgttgaa gtcaaaatac     1500

ccccaggggg tgctgtagcc aaagtagtgg ttgtcgttgc tggctcctga ttggctggag     1560

atttgcttgt agaggtggtt gttgtatgtg ggcagggccc aggttcgggt gctggtggtg     1620

atgactctgt cgcccagcca ttgggaatcg caatgccaat ttcctgagga attacccact     1680

ccatcggcac cctcgttatt gtctgccatt ggtgcgccac tgcctgtagc cattgtagta     1740

gatcccagac cagagggggc tgctggtggc tgtccgagag gctgggggtc aggtacggag     1800

tctgcgtctc cagtctgacc aaaatttaat ctttttcttg caggctgctg gcccgctttt     1860

ccggttcccg aggaggagtc tggctccaca ggagagtgct ctaccggcct cttttttccc     1920

ggagccgtct taacaggctc ctcaaccagg cccagaggtt caagaaccct ctttttcgcc     1980

tggaagactg ctcgtccgag gttgccccca aaagacgtat cttctttaag gcgctcctga     2040

aactctgcgt cggcgtggtt gtacttgagg tacgggttgt ctccgctgtc gagctgccgg     2100

tcgtaggcct tgtcgtgctc gagggccgcg gcgtctgcct cgttgaccgg ctcccccttg     2160

tcgagtccgt tgaagggtcc gaggtacttg tacccaggaa gcacaagacc cctgctgtcg     2220

tccttatgcc gctctgcggg ctttggtggt ggtgggccag gtttgagctt ccaccactgt     2280

cttattcctt cagagagagt gtcctcgagc caatctggaa gataaccatc ggcagccata     2340

cctgatttaa atcatttatt gttcagagat gcagtcatcc aaatccacat tgaccagatc     2400

gcaggcagtg caagcgtctg gcacctttcc catgatatga tgaatgtagc acagtttctg     2460

atacgccttt ttgacgacag aaacgggttg agattctgac acgggaaagc actctaaaca     2520

gtctttctgt ccgtgagtga agcagatatt tgaattctga ttcattctct cgcattgtct     2580

gcagggaaac agcatcagat tcatgcccac gtgacgagaa catttgtttt ggtacctgtc     2640

cgcgtagttg atcgaagctt ccgcgtctga cgtcgatggc tgcgcaactg actcgcgcgc     2700

ccgtttgggc tcacttatat ctgcgtcact gggggcgggt cttttcttag ctccaccctt     2760

tttgacgtag aattcatgct ccacctcaac cacgtgatcc tttgcccacc ggaaaaagtc     2820

tttcacttcc tgcttggtga cctttccaaa gtcatgatcc agacggcggg taagttcaaa     2880

tttgaacatc cggtcttgca acggctgctg gtgctcgaag gtcgttgagt tcccgtcaat     2940

cacggcgcac atgttggtgt tggaggtgac gatcacggga gtcgggtcta tctgggccga     3000

ggacttgcat ttctggtcca cacgcacctt gcttcctcca agaatggctt tggccgactc     3060

cacgaccttg gcggtcatct tcccctcctc ccaccagatc accatcttgt cgacgcaatg     3120

gtaaaaggaa agttctcatt gg                                              3142


<210> 4836
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4836
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcagagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaaaaga ttaaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggatct      600

actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acatacaaca accacctcta caagcaaatc      780

tccagccaat caggagccag caacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg gcccaaaaga ctcaacttca agctctttaa tattcaagtc      960

aaagaggtca cgcagaatgg cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tgggctcggc gcatcaagga     1080

tgcctcccgc cgtttccagc ggacgtcttc atggtcccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgctgc gtactggaaa caactttcag ttcagctaca cttttgaaga cgtgcctttc     1260

cacagcagct acgctcacag ccagagtctg gatcggctga tgaatcctct gatcgaccag     1320

tacctgtatt atctgaacaa gacacaaaca aatagtggaa ctcttcagca gtctcggcta     1380

ctgtttagcc aagctggacc aaccaacatg tctcttcaag ctaaaaactg gctgcctgga     1440

ccttgctaca gacagcagcg tctgtcaaaa caggcaaacg gcaacaacaa cagcaacttt     1500

ccctggactg cagctacaaa gtatcatcta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagtcacaa ggatgacgaa gaaaagtttt tccccatgca tggaaccctg     1620

atatttggta aacaaggaac aaatgccaac gacgcggatt tggaaaatgt catgattaca     1680

gatgaagaag aaatcagggc caccaatccc gtggctacgg agcagtacgg gactgtgtca     1740

aataatttgc aaaactcaaa cactggtcca actactggaa ctgtcaatca ccaaggagcg     1800

ttacctggta tggtgtggca ggatcgagac gtgtacctgc agggacccat ttgggccaag     1860

attcctcaca ccgatggaca ctttcatcct tctccactga cgggaggttt tggactcaaa     1920

cacccgcctc ctcagatcat gatcaaaaac actcccgttc cagccaatcc tcccacaaac     1980

ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4837
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4837
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Gly Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys Thr 
        435                 440                 445             


Gln Thr Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Asn Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Gly Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Glu Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Ala Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Thr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Thr Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4838
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4838
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc tcgcagagcg gcatcaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aaaggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc atcagcctgc gagaaagaga ttgaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag cccccacaag tctgggatct      600

actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caagcaaatc      780

tccagccaat caggagcctc gaacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgtcac ttctccccac gtgattggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgtttccagc ggacgtcttc acggtcccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgctgc gtactggaaa caaccttacc ttcagctaca cctttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtttg gaccggctga tgaatcctct gatcgaccag     1320

tatctatatt atctgaacag gacacaatca aatagtggaa ctcttcagca gtctaggcta     1380

ctgtttagcc aagctggacc caccagcatg tctcttcaag ctaaaaactg gctgcctgga     1440

ccttgctaca gacagcagcg tctttcaaag caggcaaacg acaacaacaa cagcaacttt     1500

ccctggactg cggctacaaa gtatcatcta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagccacaa agacgatgaa gaaaagtttt tccccatgca tggaaccctg     1620

atatttggta aacaaggaac aaatgctaac gacgcggatt tggagcatgt tatgattaca     1680

gatgaagaag aaatcaggac caccaatcct gtggctacag agcagtacgg aaacgtgtca     1740

aataatttgc aaaactcaaa tactggtcca actacagaaa atgtcaatca ccagggagcg     1800

ttacctggta tggtgtggca ggatcgagac gtgtacctgc agggacccat ttgggccaag     1860

attcctcaca ccgacggaca ctttcaccct tctccactga tgggaggttt tggactcaaa     1920

cacccgcctc ctcaaatcat gatcaaaaac actcccgttc cagccaatcc tcccacaaac     1980

tacagttctg ccaagtttgc ttctttcatc acacagtatt ccacgggcca ggtcagcgtg     2040

gagattgagt gggagctgcg gaaggagaac agcaaacgct ggaaccccga gatccagtat     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4839
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4839
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Leu Ala Glu Arg His Gln Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly His Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Thr Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Leu Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Ser Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Glu His Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Asn Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Glu Asn Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Tyr Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Arg Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4840
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4840
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcatcaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aaaggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaagcgggcc atcagcctgc gagaaagaga ttgaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag cccccacaag tttgggatct      600

actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caagcaaatc      780

tccagccaat caggagcctc gaacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgtcac ttctccccac gtgattggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaggaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgtttccagc ggacgtcttc atggtcccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgctgc gtactggaaa caactttacc ttcagctaca cctttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtttg gaccggctga tgaatcctct gatcgaccag     1320

tatctatatt atctgaacag gacacaatca aatagtggaa ctcttcagca gtctaggcta     1380

ctgtttagcc aagctggacc caccagcatg tctcttcaag ctaaaaactg gctgcctgga     1440

ccttgctaca gacagcagcg tctttcaaag caggcaaacg acaacaacaa cagcaacttt     1500

ccctggactg cggctacaaa gtatcgtcta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagccacaa agacgatgaa gaaaagtttt tccccatgca tggaaccctg     1620

atatttggta aacaaggaac aaatgctaac gacgcggatt tggagcatgt tatgattaca     1680

gatgaagaag aaatcaggac caccaatcct gtggctacag agcagtacgg aaacgtgtca     1740

aataatttgc aaaactcaaa tactggtcca actacagaaa atgtcaatca ccagggagcg     1800

ttacctggta tggtgtggca ggatcgagac gtgtacctgc agggacccat ttgggccaag     1860

attcctcaca ccgacggaca ctttcaccct tctccactga tgggaggttt tggactcaaa     1920

cacccgcctc ctcaaatcat gatcaaaaac actcccgttc cagccaatcc tcccacaaac     1980

ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacgggcca ggtcagcgtg     2040

gagattgagt gggagctgca gaaggagaac agcaaacgct ggaaccccga gatccagtat     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4841
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4841
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Gln Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly His Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Ser Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr Arg Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Glu His Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Asn Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Glu Asn Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4842
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4842
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcatcaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aaaggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaagcgggcc atcagcctgc gagaaagaga ttgaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag cccccacaag tttgggatct      600

actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caagcaaatc      780

tccagccaat caggagcctc gaacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgtcac ttctccccac gtgattggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgtttccagc ggacgtcttc atggtcccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgccct tccttttact gcctggagta ctttccttct     1200

cagatgctgc gtactggaaa caactttacc ttcagctaca cctttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtttg gaccggctga tgaatcctct gatcgaccag     1320

tatctatatt atctgaacag gacacaatca aatagtggaa ctcttcagca gtctaggcta     1380

ctgtttagcc aagctggacc caccagcatg tctcttcaag ctaaaaactg gctgcctgga     1440

ccttgctaca gacagcagcg tctttcaaag caggcaaacg acaacaacaa cagcaacttt     1500

ccctggactg cggctacaaa gtatcatcta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagccacaa agacgatgaa gaaaagtttt tccccatgca tgggaccctg     1620

atatttggta aacaaggaac aaatgctaac gacgcggatt tggagcatgt tatgattaca     1680

gatgaagaag aaatcaggac caccaatcct gtggctacag agcagtacgg aaacgtgtca     1740

aataatttgc aaaactcaaa tactggtcca actacagaaa atgtcaatca ccagggagcg     1800

ttacctggta tggtgtggca ggatcgagac gtgtacctgc agggacccat ttgggccaag     1860

attcctcaca ccgacggaca ctttcaccct tctccactga tgggaggttt tggactcaaa     1920

cacccgcctc ctcaaatcat gatcaaaaac actcccgttc cagccaatcc tcccacaaac     1980

ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacgggcca ggtcagcgtg     2040

gagattgagt gggagctgca gaaggagaac agcaaacgct ggaaccccga gatccagtat     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4843
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4843
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Gln Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly His Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Pro Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Ser Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Glu His Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Asn Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Glu Asn Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4844
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4844
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcaaaaaaga gggttcttga acctctgggc ctggttgagg agcctgttaa aacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaaaaga ttgaatttcg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg cttcaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacttg ggccctgccc acctacaaca accatctcta caagcaaatc      780

tccagccaat caggagccag caacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg gcccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cctttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtttg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgca gtccaggctt     1380

cagttttctc aggccggagc aagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg ccagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac caccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctgc agggcggcaa cacacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagac gtgtacctgc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttctttcatc acacagtatt ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga gatccagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg ttgacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4845
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4845
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Ser Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Gly Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4846
<211> 3161
<212> DNA
<213> Adeno-associated virus

<400> 4846
gattgaattt agcggccgcg aattcgccct tgctgcgtca actggaccaa tgagaacttt       60

ccattcaatg attgcgtcga caagatggtg atctggtggg aggagggaaa gatgaccgcc      120

aaggtcatgg agtcggccaa agccattctc ggaggaagca aggtgcgcgt ggaccagaaa      180

tgtaagtcct cggcccagat agacccgact cccgtgattg tcacctccaa caccaacatg      240

tgcgccgtga ttgacgggaa ctcaacgacc ttcgagcacc agcagccgtt gcaagaccgg      300

atgttcaaat ttgaactcac ccgccgtctg gatcatgact ttgggaaggt caccaagcag      360

gaagtcaaag actttttccg gtgggcaaag gatcacgtgg ttgaggtgga gcatgaattc      420

tacgtcaaaa agggtggagc caagaaaaga cccgccccca gtgacgcaga tataagtgag      480

cccaaacggg cgcgcgggtc agttgcgcag ccatcgacgt cagacgcgga agcttcgatc      540

aactacgcgg acaggtacca aaacaaatgt tctcgtcacg tgggcatgaa tctgatgctg      600

tttccctgca gacaatgcga gagaatgaat caaaattcaa atatctgctt cactcacgga      660

cagaaggact gtttagagtg ctttcccgtg tcagaatctc aacccgtttc tgtcgtcaaa      720

aaggcgtatc agaaactttg ctacattcat catatcatgg gaaaggtgcc agacgcttgc      780

actgcctgcg atctggtcaa tgtggatttg gatgactgca tctctgaaca ataaatgatt      840

taaatcaggt atggctgccg atggttatct tccagattgg ctcaaggaca ctctctctga      900

aggaataaga cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg      960

gcataaggac gacagcgggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa     1020

cggactcgac aagggagagc cggtcaacga ggcagacgcc gcggccctcg agtacgacaa     1080

ggcctacgac cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga     1140

cgcggagttt caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc     1200

agtcttccag gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa     1260

gacggctccg ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc     1320

gggaacagga aaagcgggcc agcagcctgc gagaaagaga ttgaattttg gtcagactgg     1380

agacgcagac tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg     1440

tctgggaact aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg     1500

cgccgacgga gtgggtaatt cctcgggaag ttggcattgc gattccacat ggatgggcga     1560

cagagtcatc accaccagca cccgaacctg ggctctgccc acctacaaca accatctgta     1620

caagcagatc tccagccaat caggagccag caacgacaac cactactttg gctacagcac     1680

cccttggggg tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca     1740

aagactcatc aacaacaact ggggattccg gcccaagaga ctcaacttca agctctttaa     1800

cattcaagtc aaggaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac     1860

cagcacggtt caggtgttta ctgactcgga gtaccagctc ccgtacgtcc ccggctcggc     1920

gcatcaagga tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata     1980

cctcaccctg aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta     2040

ctttccttct cagatgcttc gtaccggaaa caactttacc ttcagctaca cctttgagga     2100

tgttcctttc cacagcagct acgctcacag ccagagtttg gaccgtctca tgaatcctct     2160

catcgaccag tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgca     2220

gtccaggctt cagttttctc aggccggagc aagtgacatt cgggaccagt ctaggaactg     2280

gcttcctgga ccctgttacc gccagcagcg agtatcaaag acagctgcgg acaacaacaa     2340

cagtgaatac tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt     2400

gaatccgggc ccggccatgg ccagccacaa ggacgatgaa gaaaagtttt ttcctcaaag     2460

cggggttctc atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt     2520

catgattaca gacgaagagg aaatcagaac caccaatccc gtggccacgg agcagtatgg     2580

ttctgtatct accaacctcc agagcggcaa cacacaagca gctactgcag atgtcaacac     2640

acaaggcgtt cttccaggca tggtctggca ggacagagac gtgcacctgc aggggcctat     2700

ctgggcaaag attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt     2760

tggacttaaa caccctcctc cacagattct catcaagaac accccggtac ctgcaaatcc     2820

ttcgaccacc ttcagtgcgg caaagtttgc ttccttcatc acacagtatt ccacagggca     2880

ggtcagcgtg gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaaccccga     2940

gatccagtac acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa     3000

tggtgtgtat tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaatt     3060

gcttgttaat caataaaccg tttaattcgt ttcagttgaa ctttggtctc tgcgaagggc     3120

gaattcgttt aaaccctgca ggactagtcc ctttagtgag g                         3161


<210> 4847
<211> 3162
<212> DNA
<213> Adeno-associated virus

<400> 4847
gaattgaatt tagcggccgc gaattcgccc ttcgcagaga ccaaagttca actgaaacga       60

attaaacggt ttattgatta acaagcaatt acagattacg agtcaggtat ctggtgccaa      120

tggggcgagg ctctgaatac acgccattag tgtccacagt aaagtccaca ttaacagact      180

tgttgtagtt ggaagtgtac tgaatttcgg gattccagcg tttgctgttt tccttctgca      240

gctcccactc gatctccacg ctgacctgtc ccgtggagta ctgtgtgatg aaggaagcaa      300

actttgccgc actgaaggtg gtcgaaggat tcgcaggtac cggggtgttc ttgatgagaa      360

tctgtggagg agggtgttta agtccgaatc cacccatgag gggagagggg tgaaaatgtc      420

cgtccgtgtg tggaatcttt gcccagatgg gcccctgaag gtacacatct ctgtcctgcc      480

agaccatgcc tggaagaacg ccttgtgtgt tgacatctgc ggtagctgct tgtctgttgc      540

ctctctggag gttggtagat acagaaccgt actgctccgt agccacggga ttggttgtcc      600

tgatttcctc ttcgtctgta atcatgacct tttcaatgtc cacatttgtt ttctctgagc      660

cttgcttccc aaagatgaga accccgctct gaggaaaaaa cttttcttca ttgtccttgt      720

ggcttgccat ggccgggccc ggattcacca gagagtctct gccattgagg tggtacttgg      780

tagctccagt ccacgagtat tcactgttgt tgttatccgc agatgtcttt gatactcgct      840

gctggcggta acagggtcca ggaagccagt tcctagactg gtcccgaatg tcactcgctc      900

cggcctgaga aaactgaagc cttgactgcg tggtggttcc acttggagtg tttgttgtgc      960

tcaagtaata caggtactgg tcgatgagag gattcatgag acggtccaga ctctggctgt     1020

gagcgtagcc gctgtggaaa ggaacgtcct caaaagtgta gctgaaggta aagttgtttc     1080

cggtacgcag catctgagaa ggaaagtact ccaggcagta aaatgaagag cgtcctactg     1140

cctgactccc gttgttcagg gtgaggtatc catactgtgg caccatgaag acgtctgctg     1200

ggaacggcgg gaggcatcct tgatgcgccg agccgaggac gtacgggagc tggtactccg     1260

agtcagtaaa cacctgaacc gtgctggtaa ggttattggc aatcgtcgtc gtaccgtcat     1320

tctgcgtgac ctctttgact tgaatgttaa agagcttgaa gttgagtctc ttgggtcgga     1380

atccccagtt gttgttgatg agtctttgcc agtcacgtgg tgaaaagtgg cagtggaatc     1440

tgttgaagtc aaaatacccc caaggggtgc tgtagccaaa gtagtgattg tcgttcgagg     1500

ctcctgattg gctggaaatt tgtttgtaga ggtggttgtt gtaggtgggc agggcccagg     1560

ttcgggtgct ggtggtgatg actctgtcgc ccatccatgt ggaatcgcaa tgccaatttc     1620

ccgaggaatt acccactccg tcggcgccct cgttattgtc tgccattggt gcgccactgc     1680

ctgtagccat cgtattagtt cccagaccag agggggctgc tggtggctgt ccgagaggct     1740

gggggtcagg tactgagtct gcgtctccag tctgaccaaa attcaatctt tttcttgcag     1800

gctgctggcc cgcctttccg gttcccgagg aggagtctgg ctccacagga gagtgctcta     1860

ccggcctctt ttttcctgga gccgtcttga caggttcccc aaccaggccc agaggttcaa     1920

gaaccctctt tttcgcctgg aagactgctc gtccgaggtt gcccccaaaa gacgtatctt     1980

ctttaaggcg ctcctgaaac tccgcgtcgg cgtggttgta cttgaggtac gggttgtctc     2040

cgctgtcgag ctgccggtcg taggctttgt cgtgctcgag ggccgcggcg tctgcctcgt     2100

tgaccggctc tcccttgtcg agtccgttga agggtccgag gtacttgtac ccaggaagca     2160

caagacccct gctgtcgtcc ttatgccgct ctgcgggctt tggtggtggt gggccaggtt     2220

tgagcttcca ccactgtctt attccttcag agagagtgtc ctcgagccaa tctggaagat     2280

aaccatcggc agccatacct gatttaaatc atttattgtt caaagatgca gtcatccaaa     2340

tccacattga ccagatcgca ggcagtgcaa gcgtctggca cctttcccat gatatgatga     2400

atgtagcaca gtttctgata cgcctttttg acgacagaaa cgggttgaga ttctgacacg     2460

ggaaagcact ctaaacagtc tttctgtccg tgagtgaagc agatatttga attctgattc     2520

attctctcgc attgtctgca gggaaacagc atcagattca tgcccacgtg acgagaacat     2580

ttgttttggt acctgtctgc gtagttgatc gaagcttccg cgtctgacgt cgatggctgc     2640

gcaactgact cgcgcacccg tttgggctca cttatatctg cgtcactggg ggcgggtctt     2700

ttcttggctc cacccttttt gacgtagaat tcatgctcca cctcaaccac gtgatccttt     2760

gcccaccgga aaaagtcttt gacttcctgc ttggtgacct tcccaaagtc atgatccaga     2820

cggcgggtga gttcaaattt gaacatccgg tcttgcaacg gctgctggtg ttcgaaggtc     2880

gttgagttcc cgtcaatcac ggcgcacatg ttggtgttgg aggtgacgat cacgggagtc     2940

gggtctatct gggccgagga cttgcatttc tggtccacgc gcaccttgct tcctccgaga     3000

atggctttgg ccgactccac gaccttggcg gtcatcttcc cctcctccca ccagatcacc     3060

atcttgtcga cacagtcgtt gaagggaaag ttctcattgg tccagttgac gcagcaaggg     3120

cgaattcgtt taaacctgca ggactagtcc ctttagtgag gg                        3162


<210> 4848
<211> 3164
<212> DNA
<213> Adeno-associated virus

<400> 4848
gcgaattgaa tttagcggcc gcgaattcgc ccttcgcaga gaccaaagtt caactgaaac       60

gaattaaacg gtttattgat taacaagcaa ttacaaatta cgagtcaggt atctggtgcc      120

aatggggcga ggctctgaat acacgccatt agtgtccaca gtaaagtcca cattaacaga      180

cttgttgtag ttggaagtgt actgaatttc gggattccag cgtttgctgt tttccttctg      240

cagctcccac tcgatctcca cgctgacctg tcccgtggag tactgtgtga tgaaggaagc      300

aaactttgcc gcactgaagg tggtcgaagg attcgcaggt accggggtgt tcttgatgag      360

aatctgtgga ggagggtgtt taggtccgaa tccacccatg aggggagagg ggtgaaaatg      420

tccgtccgtg tgtggaatct ttgcccagat gggcccctga aggtacacat ctctgtcctg      480

ccagaccatg cctggaagaa cgccttgtgt gttgacatct gcggtagctg cttgtctgtt      540

gcctctctgg aggttggtag atacagaacc atactgctcc gtagccacgg gattggttgt      600

cctgatttcc tcttcgtctg taatcatgac cttttcaatg tccacatttg ttttctctga      660

gccttgcttc ccaaagatga gaaccccgct ctgaggaaaa aacttttctt cattgtcctt      720

gtggcttgcc atggccgggc ccggattcac cagagagtct ctgccattga ggtggtactt      780

ggtagctcca gtccacgagt attcactgtt gttgttatcc gcagatgtct ttgatactcg      840

ctgctggcgg taacagggtc caggaagcca gttcctagac tggtcccgaa tgtcactcgc      900

tccggcctga gaaaactgaa gccttgactg cgtggtggtt ccacttggag tgtttgttgt      960

gctcaagtaa tacaggtact ggtcgatgag aggattcatg agacggtcca gactctggct     1020

gtgagcgtag ctgctgtgga aaggaacgtc ctcaaaagtg tagctgaagg taaagttgtt     1080

tccggtacgc agcatctgag aaggaaagta ctccgggcag taaaatgaag agcgtcctac     1140

tgcctgactc ccgttgctca gggtgaggta tccatactgt ggcaccatga agacgtctgc     1200

tgggaacggc gggaggcatc cttgatgcgc cgagccgagg acgtacggga gctggtactc     1260

cgagtcagta aacacctgaa ccgtgctggt aaggttattg gcaatcgtcg tcgtaccgtc     1320

attctgcgtg acctctttga cttgaatgtt aaagagcttg aagttgagtc tcttgggtcg     1380

gaatccccag ttgttgttga tgagtctttg ccagtcacgt ggtgaaaagt ggcagtggaa     1440

tctgttgaag tcaaaatacc cccaaggggt gctgtagcca aagtagtgat tgtcgttcga     1500

ggctcctgat tggctggaaa tttgtctgta gaggtggttg ttgtaggtgg gcagggccca     1560

ggttcgggtg ctggtggtga tgactctgtc gcccatccat gtggaatcgc aatgccgatt     1620

tcccgaggaa ttacccactc cgtcggcgcc ctcgttattg tctgccattg gtgcgccact     1680

gcctgtagcc atcgtattag ttcccagacc agagggggct gctggtggct gtccgagagg     1740

ctgggggtca ggtactgagt ctgcgtctcc agtctgacca aaattcaatc tttttcttgc     1800

aggctgctgg cccgcctttc cggttcccga ggaggagtct ggctccacag gagagtgctc     1860

taccggcctc ttttttcccg gagccgtctt aacaggttcc ccaaccaggc ccagaggttc     1920

aagaaccctc tttttcgcct ggaagactgc tcgtccgagg ttgcccccaa aagacgtatc     1980

ttctttaagg cgctcctgaa actccgcgtc ggcgtggttg tacttgaggt acgggttgtc     2040

tccgctgtcg agctgccggt cgtaggcttt gtcgtgctcg agggccgcgg cgtctgcctc     2100

gttgaccggc tctcccttgt cgagtccgtt gaagggtccg aggtacttgt acccaggaag     2160

cacaagaccc ctgctgtcgt ccttatgccg ctctgcgggc tttggtggtg gtgggccagg     2220

tttgagcttc caccactgtc ttattccttc agagagagtg tcctcgagcc aatctggaag     2280

ataaccatcg gcagccatac ctgatttaaa tcatttattg ttcaaagatg cagtcatcca     2340

aatccacatt gaccagatcg caggcagtgc aagcgtctgg cacctttccc atgatatgat     2400

gaatgtagca cagtttctga tacgcctttt tgacgacaga aacgggttga gattctgaca     2460

cgggaaagca ctctaaacag tctttctgtc cgtgagtgaa gcagatattt gaattctgat     2520

tcattctctc gcattgtctg cagggaaaca gcatcagatt catgcccacg tgacgagaac     2580

atttgttttg gtacctgtct gcgtagttga tcgaagcttc cgcgtctgac gtcgatggct     2640

gcgcaactga ctcgcgcacc cgtttgggcc cacttatatc tgcgtcactg ggggcgggtc     2700

ttttcttggc tccacccttt ttgacgtaga attcatgctc cacctcaacc acgtgatcct     2760

ttgcccaccg gaaaaagtct ttgacttcct gcttggtgac cttcccaaag tcatgatcca     2820

gacggcgggt gagttcaaat ttgaacatcc ggtcttgcaa cggctgctgg tgttcgaagg     2880

tcgttgagtt cccgtcaatc acggcgcaca tgttggtgtt ggaggtgacg atcacgggag     2940

tcgggtctat ctgggccgag gacttgcatt tctggtccac gcgcaccttg cttcctccga     3000

gaatggcttt ggccgactcc acgaccttgg cggtcatctt cccctcctcc caccagatca     3060

ccatcttgtc gacacagtcg ttgaagggaa agttctcatt ggtccagttg acgcagcaag     3120

ggcgaattcg tttaaacctg caggactagt ccctttagtg aggg                      3164


<210> 4849
<211> 3163
<212> DNA
<213> Adeno-associated virus

<400> 4849
accctcacta aagggactag tcctgcaggt ttaaacgaat tcgcccttgc tgcgtcaact       60

ggagcaatga gaactttccc ttcaacgact gtgtcgacaa gatggtgatt tggtgggagg      120

aggggaagat gaccgccaag gtcgtggagt cggccaaagc cattctcgga ggaagcaagg      180

tgcgcgtgga ccagaaatgc aagtcctcgg cccagataga tccgactccc gtgatcgtca      240

cctccaacac caacatgtgc gccgtgattg acgggaactc aacgaccttc gaacaccagc      300

agccgttgca agaccggatg ttcaaatttg aactcacccg ccgtctggat catgactttg      360

ggaaggtcac caagcaggaa gtcaaagact ttttccggtg ggcaaaggat cacgtggttg      420

aggtggagca tggattctac gtcaaaaagg gtggagccaa gaaaagaccc gcccctagtg      480

acgcagatat aagtgagccc aaacgggtgc gcgagtcagt tgcgcagcca tcgacgtcgg      540

acgcggaagc ttcgatcaac tacgcggaca ggtaccaaaa caaatgttct cgtcacgtgg      600

gcatgaatct gatgctgttt ccctgcagac aatgcgagag aatgaatcaa aattcaaata      660

tctgcttcac tcacggacag aaagactgtt tagagtgctt tcccgtgtca gaatctcaac      720

ctgtttctgt cgtcaaaaag gcgtatcaga aactgcgcta cattcatcat atcatgggaa      780

aggtgccaga cgcttgcact gcctgcgatc tggtcaatgt ggatttggat gactgcatct      840

ctgaacaata aatgatttaa atcaggtatg gctgccgatg gttatcttcc agattggctc      900

gaggacactc tctctgaagg aataagacag tggtggaagc tcaaacctgg cccaccacca      960

ccaaagcccg cagagcggca taaggacgac agcaggggtc ttgtgcttcc tgggtacaag     1020

tacctcggac ccttcaacgg actcgacaag ggagagccgg tcaacgaggc agacgccgcg     1080

gccctcgagc acgacaaggc ctacgaccgg cagctcgaca gcggagacaa cccgtacctc     1140

aagtacaacc acgccgacgc ggagtttcag gagcgtctta aagaagatac gtcttttggg     1200

ggcaacctcg gacgagcagt cttccaggcg aaaaagaggg ttcttgaacc tctgggcctg     1260

gttgaggaac ctgttaagac ggctccggga aaaaagaggc cggtagagca ctctcctgcg     1320

gagccagact cctcctcggg aaccggaaaa gcgggccagc agcctgcaag aaaaagactg     1380

aatttcggtc agactggaga cgcagactcc gtacctgacc cccagcctct cggacagcca     1440

ccagcagccc ccacaagttt gggatctact acaatggcta caggcagtgg cgcaccaatg     1500

gcagacaata acgagggtgc cgatggagtg ggtaattcct caggaaattg gcattgcgat     1560

tcccaatggc tgggcgacag agtcatcacc accagcaccc gaacctgggc cctgcccacc     1620

tacaacaacc acctttacaa gcaaatctcc agccaatcag gagcctcaaa cgacaaccac     1680

tactttggct acagcacccc ctgggggtat tttgacttca acagattcca ctgccacttt     1740

tcaccacgtg actggcaaag actcatcaac aacaactggg gattccgacc caagagactc     1800

aacttcaagc tctttaacat tcaagtcaaa gaggtcacgc agaatgacgg tacgacgacg     1860

attgccaata accttaccag cacggttcag gtgtttactg actcggagta ccagctcccg     1920

tacgtcctcg gctcggcgca tcaaggatgc ctcccgccgt ttccagcgga cgtcttcatg     1980

gtcccacagt atggatacct caccctgaac aacgggagtc aggcggtagg acgctcttcc     2040

ttttactgcc tggagtgctt tccttctcag atgctgcgta ctggaaacaa ctttcagttc     2100

agctacactt ttgaagacgt gcctttccac agcagctacg ctcacagcca gagtttggat     2160

cggctgatga atcctctgat cgaccagtac ctgtattatc taaacagaac acaaacagct     2220

agtggaactc agcagtctcg gctactgttt agccaagctg gacccacaag catgtctctt     2280

caagctaaaa actggctgcc tggaccgtgt tatcgccagc agcgtttgtc aaagcaggca     2340

aacgacaaca acaacagcaa ctttccctgg actggagcta ccaagtacca cctcaatggc     2400

agagactctt tggtgaaccc gggcccggcc atggccagcc acaaggacga tgaagaaaag     2460

tttttcccca tgcatggaac cctaatattt ggtaaagaag gaacaaatgc taccaacgcg     2520

gaattggaaa atgtcatgat tacagatgaa gaggaaatca ggaccaccaa tcccgtggct     2580

acagagcagt acggatatgt gtcaaataat ttgcaaaact caaatactgc tgcaagtact     2640

gaaactgtga atcaccaagg agcattacct ggtatggtgt ggcaggatcg agacgtgtac     2700

ctgcagggac ccatttgggc caagattcct cacaccgatg gacactttca tccttctcca     2760

ctgatgggag gttttggact caaacacccg cctcctcaga ttatgatcaa aaacactccc     2820

gttccagcca atcctcccac aaacttcagt tctgccaagt ttgcttcctt catcacacag     2880

tattccacgg gacaggtcag cgtggagatc gagtgggagc tgcagaagga gaacagcaaa     2940

cgctggaatc ccgaaattca gtacacttcc aactacaaca aatctgttaa tgtggacttt     3000

actgtggaca ctaatggtgt gtattcagag cctcgcccca ttggcaccag atacctgact     3060

cgtaatctgt aattgcttgt taatcaataa accgtttaat tcgtttcagt tgaactttgg     3120

tctctgcgaa gggcgaattc gcggccgcta aattcaattc gcc                       3163


<210> 4850
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4850
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Tyr Lys Gly Glu Pro 
    50                  55                  60                  


Val Asp Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Gly Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Asn Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Arg Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Gly Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Leu Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys Thr 
        435                 440                 445             


Gln Ser Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Asp Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Tyr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asp Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Pro Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4851
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4851
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactctac      180

aagggagagc cggtcgacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gccaaaaaga gggttcttga acctctgggc ttggttgggg agcctgttaa aacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaagcgggca accagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggatct      600

actacaatgg ctacaggcag tggcgcacca gtggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggctctgccc acctacaata accacctcta caagcaaatc      780

tccagccaat caggagcctc aaacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgaccggca aagactcatc      900

aacaacaact ggggattccg accaaaaaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcggg gtaccagctc ccgtacgtcc tcggcttggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgctgc gtactggaaa caactttcag ttcagctaca cctttgaaga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gatcggctga tgaatcctct gatcgaccag     1320

tacctgtatt atctgaacaa gacacaatca aatagtggaa ctcttcagca gtctcggcta     1380

ctgtttagcc aagctggacc caccagcatg tctcttcaag ctaaaaactg gctgcctgga     1440

ccttgctaca gacagcagcg tctgtcaaag caggcaaacg acaacaacaa cagcaacttt     1500

ccctggactg cggctacaaa gtatcatcta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagccacaa agacgatgaa gaaaagtttt tccccatgca tggaaccctg     1620

atatttggta aacaaggaac aaatgctaac gacgcggatt tggacaatgt catgattaca     1680

gatgaagaag aaatccgcac caccaatccc gtggctacgg agcagtacgg atatgtgtca     1740

aataatttgc aaaactcaaa tactggtcca actactggaa ctgtcaatca ccaaggagcg     1800

ttacctggta tggtgtggca ggatcgagac gtgtacctgc agggacccat ttgggccaag     1860

attcctcaca ccgatggaca ctttcatcct tctccactta tgggaggttt tggactcaaa     1920

cacccacctc ctcagatcat gattaaaaac actcccgttc cagccaatcc tcccacaaac     1980

ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacgggaca agtcagcgtg     2040

gagatcgagt gggagctgca gaaggaggac agcaaacgct ggaaccccga gatccagtac     2100

acttccaact ataacaaacc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4852
<211> 3161
<212> DNA
<213> Adeno-associated virus

<400> 4852
cgaattgatt tagcggccgc gaattcgccc ttcgcagaga ccaaagttca actgaaacga       60

attaaacggt ttattgatta acaagcaatt acagattacg agtcaggtat ctggtgccaa      120

tggggcgagg ctctgaatac acaccattag tgtccacagt aaagtccaca ttaacagatt      180

tgttgtagtt ggaagtgtac tggatctcgg gattccagcg tttgctgttc tccttctgta      240

gctcccactc gatctccacg ctgacccgcc ccgtggaata ctgtgtgatg aaggaagcaa      300

actttgccgc actgaaggtg gtcgaaggat tcgcaggtac cggggtgttt ttgatgagaa      360

tctgtggagg agggtgttta agtccgaatc cgcccatgag gggagagggg tgaaaatgtc      420

cgtccgtgtg cggaatcttt gcccagatag gcccctgcag gtacacgtct ctgtcctgcc      480

agaccatgcc tggaagaacg ccttgtgtgt tgacatctgc agtagatgct tgtgtgttgc      540

cgctctggag gttggtagat acagaaccat actgctccgt ggccacggga ttggtggttc      600

tgatttcctc ttcgtctgta atcatgacct tttcaatgtc cacatttgtt ttctctgatc      660

cttgttttcc aaagatgaga accccgctct gaggaaaaaa cttttcttca tcgtccttgt      720

ggctggccat tgccgggccc ggattcacca gagagtctct gccattgagg tggtacttgg      780

tagctccaat ccacgagtat tcactgttgt tgttgtccgc agatgtcttt gatactcgct      840

gctggcggta acagggtcca ggaagccagt tcctagactg atcccgaatg tcactcgctc      900

cggcctgaga aaactgaagc ctggactgcg tggtggttcc gcttggagtg tttgttctgc      960

tcaagtaata caggtactgg tcgatgagag gattcatgag acggtccaaa ctctggctgt     1020

gagcgtagct gctgtggaaa ggaacatcct caaaggtgta gctgaaggta aagttgtttc     1080

cggtacgcag catctgagaa gggaagtact ccaggcagta aaatgaagag cgtcctactg     1140

cctgactccc gttgttcagg gtgaggtatc catactgtgg caccatgaag acgtctgctg     1200

ggaacggcgg gaggcatcct tgatgcgccg agccgaggac gtacgggagc tggtactccg     1260

agtcagtaaa cacctgaacc gtgctggtaa ggttattggc aatcgtcgtc gtaccatcat     1320

tctgcgtgac ctctctgact tgaatgttaa agagcttgaa gttgagtctc ttgggccgga     1380

atccccagtt gttgttgatg agtctttgcc agtcacgtgg tgaaaagtgg cagtggaatc     1440

tgttgaagtc aaaatacccc caaggggtgc tgtagccaaa gtagtggttg tcgttgctgg     1500

ctcctgattg gctggaaatc tgcttgtaca gatggttgtt gtaggtgggc agagcccagg     1560

ttcgggtgct ggtggtgatg actctgtcgc ccatccatgt ggaatcgcaa tgccaatttc     1620

ccgaggaatt acccactccg tcggcgccat cgttattgtc tgccattggt gcgccactgc     1680

ctgtagccat cgtattagtt cccagaccag agggggctgc tggtggctgt ccgagaggct     1740

gggggtcagg tacggagtct gcgtctccag tctgaccgaa attcaatctc tttcttgcag     1800

gctggttgcc cgcttttccg gttcccgagg aggagtctgg ctccacagga gagtgctcta     1860

ccggcctctt ttttcccgga gccgtcttaa caggctcctc aaccaggccc agaggttcaa     1920

gaaccctctt ttttgcctgg aagactgctc gtccgaggtt gcccccaaaa gacgtatctt     1980

ctttaaggcg ctcctgaaac tccgcgtcgg cgtggtcgta cttgaggtac gggttgtctc     2040

cgctgtcgag ctgccggtcg taggccttgt cgtgctcgag ggccgcggcg tctgcctcgt     2100

tgaccggctc tcccttgtcg agtccgttga agggtccgag gtacttgtac ccaggaagca     2160

caagacccct gctgtcgtcc ttatgccgct ctgcgggctt tggtggtggt gggccaggtt     2220

tgagcttcca ccactgtctt attccttcag agagagtgtc ctcgagccaa tctggaagat     2280

aaccatcggc agccatacct gatttaaatc atttattgtt cagagatgca gtcatccaaa     2340

tccacattga ccagatcgca ggcagtgcaa gcgtctggca cctttcccat gatatgatga     2400

atgtagcaaa gtttctgata cgcctttttg acgacagaaa cgggttgaga ttctgacacg     2460

ggaaagcact ctaaacagtc tttctgtccg tgagtgaagc agatatttga attctgattc     2520

attctctcgc attgtctgca gggaaacagc atcagattca tgcccacgtg acgagaacat     2580

ttgttttggt acctgtccgc gtagttgatc gaagcttccg cgtctgacgt cgatggctgc     2640

gcaactgact cgcgcgcccg tttgggctca cttatatctg cgtcactggg ggcgggtctt     2700

ttcttggctc cacccttttt gacgtagaat tcatgctcca cctcaaccac gtgatccttt     2760

gcccaccgga aaaagtcttt cacttcctgc ttggtgacct tcccaaagtc atgatccaga     2820

cggcgggtta gttcaaattt gaacatccgg tcttgcaacg gctgctggtg ttcgaaggtc     2880

gttgagttcc cgtcaatcac ggcgcacatg ttggtgttgg aggtggcgat cacgggagtc     2940

gggtctatct gggccgagga cttgcacttt tggtccacgc gcaccttgct tcctccgaga     3000

atggcttcgg ccgattccac gaccttggcg gtcatctttc cctcctccca ccagatcacc     3060

atcttgtcga cacagtcgtt gaagggaaag ttctcattgg tccagttgac gcagcaaggg     3120

cgaattcgtt taaacctgca ggaactagtc ccttagtgag g                         3161


<210> 4853
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4853
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Tyr Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Gly Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Asn Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys Thr 
        435                 440                 445             


Gln Ser Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Asp Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Tyr Val Ser Asn Asn Leu Gln Asp Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4854
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4854
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccgccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactctac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccgg cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gccaaaaaga gggttcttga acctctgggc ttggttgagg agcctgttaa aacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaagcgggca accagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggatct      600

actacaatgg ctacaggcag tggcgcacca gtggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggctctgccc acctacaaca accacctcta caagcaaatc      780

tccagccaat caggagcctc aaacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg accaaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgctgc gtactggaaa caactttcag ttcagctaca cctttgaaga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gatcggctga tgaatcctct gatcgaccag     1320

tacctgtatt atctgaacaa gacacaatca aatagtggaa cccttcagca gtctcggcta     1380

ctgtttagcc aagctggacc caccagcatg tctcttcaag ctaaaaactg gctgcctgga     1440

ccttgctaca gacagcagcg tctgtcaaag caggcaaacg acaacaacaa cagcaacttt     1500

ccctggactg cggctacaaa gtatcatcta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagccacaa agacgatgaa gaaaagtttt tccccatgca tggaaccctg     1620

atatttggta aacaaggaac aaatgctaac gacgcggatt tggacaatgt catgattaca     1680

gatgaagaag aaatccgcac caccaatccc gtggctacgg agcagtacgg atatgtgtca     1740

aataatttgc aagactcaaa tactggtcca actactggaa ctgtcaatca ccaaggagcg     1800

ttacctggta tggtgtggca ggatcgagac gtgtacctgc agggacccat ttgggccaag     1860

attcctcaca ccgatggaca ctttcatcct tctccactta tgggaggttt tggactcaaa     1920

cacccacctc ctcagatcat gattaaaaac actcccgttc cagccaatcc tcccacaaac     1980

ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacgggaca agtcagcgta     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaaccccga gatccagtac     2100

acttccaact ataacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4855
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4855
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Cys Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Pro Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Arg Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4856
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 4856
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctgc aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagacag gccagcagcc cgcgaaaaag agactcaact ttgggcagac tggcgactca      540

gagtcagtgc ccgaccctca accaatcgga gaaccccccg caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctc cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacatcggg aggaagcacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcaacttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taaccttacc     1020

agcacgattc aggtctttac ggactcggaa taccagctcc cgtacgtcct cggctctgcg     1080

caccagggct gcccgcctcc gttcccggcg gacgtcttca tgattcctca gtacgggtac     1140

ctgactctga acaacggcag tcaggccgtg ggccgttcct ccttctactg cctggagtac     1200

tttccttctc aaatgcggag aacgggcaac aactttgagt tcagctacca gtttgaggac     1260

gtgccttttc acagcagcta cgcgcatagc caaagcctgg accggctgat gaaccccctc     1320

atcgaccagt acctgtacta cctgtctcgg actcagtcca cgggaggtac cgcaggaact     1380

cagcagttgc tattttctca ggccgggcct aataacatgt cggctcaggc caaaaactgg     1440

ctacccgggc cctgctaccg gcagcaacgc gtctccacga cactgtcgca aaataacaac     1500

agcaactttg cttggaccgg tgccaccaag tatcatctga atggcagaga ctctctggta     1560

aatcccggtg tcgctatggc aacgcacaag gacgacgaag agcgattttt tccatccagc     1620

ggagtcttga tgtttgggaa acagggagct ggaaaagaca acgtggacta tagcagcgtt     1680

atgctaacca gtgaggaaga aatcaaaacc accaacccag tggccacaga acagtacggc     1740

gtggtggccg ataacctgca acagcaaaac gccgctccta ttgtaggggc cgtcaacagt     1800

caaggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatc     1860

tgggccaaga ttcctcacac ggacggcaac tttcatcctt cgccgctgat gggaggcttt     1920

ggactgaaac acccgcctcc tcagatcctg attaagaata cacctgttcc cgcggatcct     1980

ccaactacct tcagtcaagc caagctggcg tcgttcatca cgcagtacag caccggacag     2040

gtcagcgtgg aaattgaatg ggagctgcag aaagagaaca gcaagcgctg gaacccagag     2100

attcagtata cttccaacta taacaaatct gttaatgtgg actttactgt ggacactaat     2160

ggtgtgtatt cagagcctcg ccccattggc accagatacc tgactcgtaa tctgtaa        2217


<210> 4857
<211> 3167
<212> DNA
<213> Adeno-associated virus

<400> 4857
attgaattta gcggccgcga attcgccctt cgcagagacc aaagttcaac tgaaacgaat       60

taaacggttt attgattaac aagcaattac agattacgag tcaggtacct ggtgccaatg      120

gggcgaggct ctgaatacac accattagtg tccacagtaa agtccacatt aacagatttg      180

ttgtagttgg aagtgtactg aatctcggga ttccagcgtt tgctgttctc cttctgcagc      240

tcccactcga tctccacgct gacctgcccc gtggagtact gtgtaatgaa ggaagcaaac      300

tttgccgcac tgaaggtagt cgaaggattc gcaggtaccg gggtgttctt gatgagaatc      360

tgcgggggag ggtgtttaag tccgaatccg cccatgaggg gagaggggtg aaaatgtccg      420

tccgtgtgtg gaatctttgc ccagatgggc ccctgcaggt acacgtctct gtcctgccac      480

accatgcctg gaagaacgcc ttgtgtgttg acatctgagg tagctgcttg tgtgttgccg      540

ctctggaggt tggtagatac agaaccatac tgctccgtag ccacgggatt ggtggtcctg      600

atttcctctt cgtctgtaat catgaccttt tcaatgtcca cattagtttt tcccgagtct      660

tgttttccaa agatgagaac cccgctctga ggaaaaaact tttcttcatc gtccttgtgg      720

ctggccatgg ccgggcccgg attcaccaga gagtctcttc cattaaggtg gtacttggta      780

gctccagtcc acgagtattc actgttgttg ttatccgcag atgtctttga tactcgctgc      840

tggcggtaac agggtccagg aagccagttc ctagactggt cccgaatgtc acttgctccg      900

gcctgagaaa actgaagcct tgactgcgtg gtggttccgc ttggagtgtt tgttctgctc      960

aagtaataca ggtactggtc gatgagagga ttcatgagac ggtccaaact ctggctgtgg     1020

gcgtagctgc tgtggaaagg aacgtcctca aaggtgtagc tgaaggtaaa gttgtttccg     1080

gtacgcagca tctgagaagg aaagtactcc aggcagtaaa atgaagagcg tcctactgcc     1140

tgactcccgt tgttcagggt gaggtatcca tactgtggca ccatgaagac gtctgctggg     1200

aacggcggga ggcatccttg atgcgccgag ccgaggacgt acgggagctg gtactccgag     1260

tcagtaaaca cctgaaccgt gctggtaagg ttattggcaa tcgtcgtcgt accgtcattc     1320

tgcgtgacct ccttgacttg aatgttaaag agcttgaagt tgagtctttt gggccggaat     1380

ccccaattgt tgttgatgag tctttgccag tcacgtggcg aaaagtggca gtggaatctg     1440

ttgaagtcaa aataccccca aggggtgctg tagccaaagt agtggttgtc gtttgaggct     1500

cctgattggc tggaaatctg cttgtagagg tggttgttgt aggtgggcag agcccaggtg     1560

cgggtgctgg tggtgatgac tctgtcgccc atccatgtgg aatcgcaatg ccaatttccc     1620

gaggaattac ccactccgtc ggcgccctcg ttattgtctg ccattggtgc gccactgcct     1680

gtagccatcg tattagttcc cagaccagag ggggctgctg gtggctgtcc gagaggctgg     1740

gggtcaggta cggagtctgc gtctccagtc tgaccgaaat tcaatctctt tcttgcaggc     1800

tgctggcccg cttttccggt tcccgaggag gagtctggct ccgcaggaga gtgctctacc     1860

ggcctctttt ttcccggagc cgtcttaaca ggttcctcaa ccaggcccag aggttcaaga     1920

accctctttt tcgcctggaa gactgctcgt ccgaggttgc ccccaaaaga cgtatcttct     1980

ttaagacgct cctggaactc cgcgtcggcg tggttgtact tggggtacgg gttgtctccg     2040

ctgtcgagct gccggtcgta ggccttgtcg tgctcgaggg ccgcggcgtc tgcctcgttg     2100

accggctctc ccttgtcgag tccgttgaag ggtccaaggt acttgtaccc aggaagcaca     2160

agacccctgc tgtcgtcctt atgccgctct gcgggctttg gtggtggtgg gccaggtttg     2220

agcttccacc actgtcttat tccttcagag agagtgtcct cgagccaatc tggaagataa     2280

ccatcggcag ccatacctga tttaaatcat ttattgttca gagatgcagt catccaaatc     2340

cacattgacc agatcgcaag cagtgcaagc gtctggcacc tttcccatga tatgatgaat     2400

gtagcacagt ttctgatacg cctttttgac gacagaaacg ggttgagatt ctgacacggg     2460

aaagcactct aaacagtctt tctgtccgtg agtgaagcag atatttgaat tctgattcat     2520

tctctcgcat tgtctgcagg gaaacagcat cagattcatg cccacgtgac gagaacattt     2580

gttttggtac ctgtccgcgt agttgattga agcttccgcg tctgacgtcg atggctgcgc     2640

aactgactcg cgcgcccgtt tgggctcact tatatctgcg tcactggggg cgggtctttt     2700

tttggctcca ccctttttga cgtagaattc atgctctacc tcaaccacgt gatcctttgc     2760

ccaccggaaa aagtctttga cttcctgctt ggtgaccttc ccaaagtcat gatccagacg     2820

gcgggtgagt tcaaatttga acatccggtc ttgcaacggc tgctggtgtt cgaaggtcgt     2880

tgagttcccg tcaatcactg cgcacatgtt ggtgttggag gtgacaatca cgggagtcgg     2940

gtctatctgg gccgaggact tgcatttctg gtccacgcgc accttgcttc ctccgagaat     3000

ggctttggcc gactccacga ccttggcggt catcttcccc tcctcccacc agatcaccat     3060

cttgtcgacg caatcattga aaggaaagtt ctcattggtc cagttgacgc agccgtagaa     3120

agggcgaatt cgtttaaacc tgcaggacta gtccctttag tgagggt                   3167


<210> 4858
<211> 3161
<212> DNA
<213> Adeno-associated virus

<400> 4858
aattgaattt agcggccgcg aattcgccct tcgcagagac caaagttcaa ctgaaacgaa       60

ttaaacggtt tattgattaa caagcaatta cagattacga gtcaggtatc tggtgccaat      120

ggggcgaggc tctgaataca caccattagt gtccacagta aagtccacat taacagattt      180

gttgtagttg gaagtgtact gaatctcggg attccagcgt ttgctgttct ccttctgcag      240

ctcccactcg atctccacgc tgacctgccc cgtggagtac tgtgtaatga aggaagcaaa      300

ctttgccgca ctgaaggtag tcgaaggatt cgcaggtacc ggggtgttct tgatgagaat      360

ctgcggggga gggtgtttaa gtccgaatcc gcccatgagg ggagaggggt gaaaatgtcc      420

gtccgtgtgt ggaatctttg cccagatggg cccctgcagg tacacgtctc tgtcctgcca      480

caccatgcct ggaagaacgc cttgtgtgtt gacatctgag gtagctgctt gtgtgttgcc      540

gctctggagg ttggtagata cagaaccata ctgctccgta gccacgggat tggtggtcct      600

gatttcctct tcgtctgtaa tcatgacctt ttcaatgtcc acattagttt ttcccgagtc      660

ttgttttcca aagatgagaa ccccgctctg aggaaaaaac ttttcttcat cgtccttgtg      720

gctggccatg gccgggcccg gattcaccag agagtctctt ccattaaggt ggtacttggt      780

agctccagtc cacgagtatt cactgttgtt gttatccgca gatgtctttg atactcgctg      840

ctggcggtaa cagggtccag gaagccagtt cctagactgg tcccgaatgt cacttgctcc      900

ggcctgagaa aactgaagcc ttgactgcgt ggtggttccg cttggagtgt ttgttctgct      960

caagtaatac aggtactggt cgacgagagg attcatgaga cggtccaaac tctggctgtg     1020

ggcgtagctg ctgtggaaag gaacgtcctc aaaggtgtag ctgaaggtaa agttgtttcc     1080

ggtacgcagc atctgagaag gaaagtactc caggcagtaa aatgaagagc gtcctactgc     1140

ctgactcccg ttgttcaggg tgaggtatcc atactgtggc accatgaaga cgtctgctgg     1200

gaacggcggg aggcatcctt gatgcgccga gccgaggacg tacgggagct ggtactccga     1260

gtcagtaaac acctgaaccg tgctggtaag gttattggca atcgtcgtcg taccgtcatt     1320

ctgcgtgacc tccttgactt gaatgttaaa gagcttgaag ttgagtcttt tgggccggga     1380

tccccaattg ttgttgatga gtctttgcca gtcacgtggc gaaaagtggc agtggaatct     1440

gttgaagtca aaataccccc aaggggtgct gtagccaaag tagtggttgt cgtttgaggc     1500

tcctgattgg ctggaaatct gcctgtagag gtggttgttg taggtgggca gagcccaggt     1560

gcgggtgctg gtggtgatga ctctgtcgcc catccatgtg gaatcgcaat gccaatttcc     1620

cgaggaatta cccactccgt cggcgccctc gttattgtct gccattggtg cgccactgcc     1680

tgtagccatc gtattagttc ccagaccaga gggggctgct ggtggctgtc cgagaggctg     1740

ggggtcaggt acggagtctg cgtctccagt ctgaccgaaa ttcaatctcc ttcttgcagg     1800

ctgctggccc gcttttccgg ttcccgagga ggagtctggc tccgcaagag agtgctctac     1860

cggcctcttt tttcccggag ccgtcttaac aggttcctca accaggccca gaggttcaag     1920

aaccctcttt ttcgcctgga agactgctcg tccgaggttg cccccaaaag acgtatcttc     1980

tttaagacgc tcctggaact ccgcgtcggc gtggttgtac ttgaggtacg ggttgtctcc     2040

gccgtcgagc tgccggtcgt aggccttgtc gtgctcgagg gccgcggcgt ctgcctcgtt     2100

gaccggctct cccttgtcga gtccgttgaa gggtccaagg tacttgtacc caggaagcac     2160

aagacccctg ctgtcgtcct tatgccgctc tgcgggcttt ggtggtggtg ggccaggttt     2220

gagcttccac cactgtctta ttccttcaga gagagtgtcc tcgagccaat ctggaagata     2280

accatcggca gccatacctg atttaaatca tttattgttc agagatgcag tcatccaaat     2340

ccacattgac cagatcgcaa gcagtgcaag cgtctggcac ctttcccatg atatgatgaa     2400

tgtagcacag tttctgatac gcctttttga cgacagaaac gggttgagat tctgacacgg     2460

gaaagcactc taaacagtct ttctgtccgt gagtgaagca gatatttgaa ttctgattca     2520

ttctctcgca ttgtctgcag ggaaacagca tcagattcat gcccacgtga cgagaacatt     2580

tgttttggta cctgtccgcg tagttgattg aagcttccgc gtctgacgtc gatggctgcg     2640

caactgactc gcgcgcccgt ttgggctcac ttatatctgc gtcactgggg gcgggtcttt     2700

ttttggctcc accctttttg acgtagaatt catgctctac ctcaaccacg tgatcctttg     2760

cccaccggaa aaagtctttg acttcctgct tggtgacctt cccaaagtca tgatccagac     2820

ggcgggtgag ttcaaatttg aacatccggt cttgcaacgg ctgctggtgt tcgaaggtcg     2880

ttgagttccc gtcaatcact gcgcacatgt tggtgttgga ggtgacaatc acgggagtcg     2940

ggtctatctg ggccgaggac ttgcatttct ggtccacgcg caccttgctt cctccgagaa     3000

tggctttggc cgactccacg accttggcgg tcatcttccc ctcctcccac cagatcacca     3060

tcttgtcgac gcaatcattg aaaggaaagt tctcattggt ccagttgacg cagcaagggc     3120

gaattcgttt aaacctgcag gactagtccc tttagtgagg g                         3161


<210> 4859
<211> 3172
<212> DNA
<213> Adeno-associated virus

<400> 4859
gattgaattt agcggccgcg aattcgccct tgctgcgtca actggaccaa tgagaacttt       60

cccttcaacg attgcgtcga caagatggtg atctggtggg aggagggcaa gatgaccgcc      120

aaggtcgtgg agtccgccaa ggccattctg ggtggaagca aggtgcgcgt ggaccaaaag      180

tgcaagtcat cggcccagat cgaccccacg cccgtgatcg tcacctccaa caccaacatg      240

tgcgccgtga tcgacgggaa cagcaccacc ttcgagcacc agcagcccct gcaggaccgc      300

atgttcaagt tcgagctcac ccgccgtctg gagcacgact ttggcaaggt gaccaagcag      360

gaagtcaaag agttcttccg ctgggctcag gatcacgtga ctgaggtggc gcatgagttc      420

tacgtcagaa agggcggagc caccaaaaga cccgccccca gtgacgcgga tataagcgag      480

cccaagcggg cctgcccctc agttgcggag ccatcgacgt cagacgcgga agcaccggtg      540

gactttgcgg acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg      600

tttccctgca agacatgcga gagaatgaat cagaatttca acgtctgctt cacgcacggg      660

gtcagagact gctcagagtg cttccccggc gcgtcggaat ctcaacccgt cgtcagaaaa      720

aagacgtatc agaaactgtg cgcgattcat catctgctgg ggcgggcacc cgagattgcg      780

tgttcggcct gcgatctcgt caacgtggac ttggatgact gtgtttctga gcaataaatg      840

acttaaacca ggtatggctg ctgacggtta tcttccagat tggctcgagg acaacctctc      900

tgagggcatt cgcgagtggt gggacctgaa acctggagcc cccaagccca aggccaacca      960

gcagaagcag gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt     1020

caacggactc gacaaggggg agcccgtcaa cgcggcggac gcagcggccc tcgagcacga     1080

caaggcctac gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc     1140

cgacgccgag tttcaggagc gtctgcaaga agatacgtct tttgggggca acctcgggcg     1200

agcagtcttc caggccaaga agcgggttct cgaacctctc ggtctggttg aggaagctgc     1260

taagacggct cctggaaaga agagaccggt agaaccgtca cctcagcgtt cccccgactc     1320

ctccgcgggc atcggcaaga aaggccagca gcccgctaaa aagagactga actttggtca     1380

gactggcgac tcagagtcag tccccgaccc tcaaccaatc ggagaaccac cagcaggccc     1440

ctctggtctg ggatctggta caatggctgc aggcggtggc gctccaatgg cagacaataa     1500

cgaaggcgcc gacggagtgg gtagttcctc aggaaattgg cattgcgatt ccacatggct     1560

gggcgacaga gtcatcacca ccagcacccg aacctgggcc ctgcccacct acaacaacca     1620

cctctacaag caaatatcca atgggacatc gggaggaagc accaacgaca acacctactt     1680

cggctacagc accccctggg ggtattttga cttcaacaga ttccactgcc acttctcacc     1740

acgtgactgg cagcgactca tcaacaacaa ctggggattc cggccaaaaa gactcagctt     1800

caagctcttc aacatccagg tcaaggaggt cacgcagaat gaaggcaccg agaccatcgc     1860

caataacctt accagcacga ttcaggtatt tacggactcg gaataccagc tgccgtacgt     1920

cctcggctcc gcgcaccagg gctgcctgcc tccgttcccg gcggacgtct tcatgattcc     1980

ccagtacggc taccttacac tgaacaatgg aagtcaagcc gtaggccgtt cctccttcta     2040

ctgcctggaa tattttccat ctcaaatgct gcgaactgga aacaattttg aattcagcta     2100

caccttcgag gacgtgcctt tccacagcag ctgcgcacac agccagagct cggaccgact     2160

gatgaatcct ctcatcgacc agtacctgta ctacttatcc agaactcggt ccacaggagg     2220

aactcaaggt acccagcaat tgttattttc tcaagctggg cctgcaaaca tgtcggctca     2280

ggctaagaac tggctacctg gaccttgcta ccggcagcag cgagtctcta cgacactgtc     2340

gcaaaacaac aacagcaact ttgcttggac tggtgccacc aaatatcacc tgaacggaag     2400

agactctttg gtaaatcccg gtgtcgccat ggcaacccac aaggacgacg aggaacgctt     2460

cttcccgtcg agtggagtcc tgatgtttgg aaaacagggt gctggaagag acaatgtgga     2520

ctacagcagc gttatgctaa ccagcgaaga agaaattaaa accactaacc ctgtagccac     2580

agaacaatac ggtgtggtgg ctgacaactt gcagcaaacc aatacagggc ctattgtggg     2640

aaatgtcaac agccaaggag ccttacctgg catggtctgg cagaaccgag acgtgtacct     2700

gcagggtccc atctgggcca agattcctca cacggacggc aacttccacc cttcaccgct     2760

aatgggagga tttggactga agcacccacc tcctcagatc ctgatcaaga acacgccggt     2820

acctgcggat cctccaacaa cgttcagcca ggcgaaattg gcttccttca ttacgcagta     2880

cagcaccgga caggtcagcg tggaaatcga gtgggagctg cagaaggaga acagcaaacg     2940

ctggaaccca gagattcagt acacttcaaa ctactacaaa tctacaaatg tggactttgc     3000

tgtcaataca gagggaactt attctgagcc tcgccccatt ggtactcgtt acctcacccg     3060

taatctgtaa ttgctggtta atcaataaac cgtttgattc gtttcagttg aactttggtc     3120

tctgcgaagg gcgaattcgt ttaaacctgc aggactagtc cctttagtga gg             3172


<210> 4860
<211> 3172
<212> DNA
<213> Adeno-associated virus

<400> 4860
gattgaattt agcggccgcg aattcgccct tgctgcgtca actggaccaa tgagaacttt       60

cccttcaacg attgcgtcga caagatggtg atctggtggg aggagggcaa gatgaccgcc      120

aaggtcgtgg agtccgccaa ggccattctg ggtggaagca aggtgcgcgt ggaccaaaag      180

tgcaagtcat cggcccagat cgaccccacg cccgtgatcg tcacctccaa caccaacatg      240

tgcgccgtga tcggcgggaa cagcaccacc ttcgagcacc agcagcccct gcaggaccgc      300

atgttcaagt tcgagctcac ccgccgtctg gagcacgact ttggcaaggt gaccaagcag      360

gaagtcaaag agttcttccg ctgggctcag gatcacgtga ctgaggtggc gcatgagttc      420

tacgtcagaa agggcggagc caccaaaaga cccgccccca gtgacgcgga tataagcgag      480

cccaagcggg cctgcccctc agttgcggag ccatcgacgt cagacgcgga agcaccggtg      540

gactttgcgg acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg      600

tttccctgca agacatgcga gagaatgaat cagaatttca acgtctgctt cacgcacggg      660

gtcagagact gctcagagtg cctccccggc gcgtcagaat ctcaacccgt cgtcagaaaa      720

aagacgtatc agaaactgtg cgcgattcat catctgctgg ggcgggcacc cgagattgcg      780

tgttcggcct gcgatctcgt caacgtggac ttggatgact gtgtttctga gcaataaatg      840

acttaaacca ggtatggctg ctgacggtta tcttccagat tggctcgagg acaacctctc      900

tgagggcatt cgcgagtggt gggacctgaa acctggagcc cccaagccca aggccaacca      960

gcagaagcag gacgacggcc ggggtctggt gcttcttggc tacaagtacc tcggaccctt     1020

caacggactc gacaaggggg agcccgtcaa tgcggcggac gcagcggccc tcgagcacga     1080

caaggcctac gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc     1140

cgacgccgag tttcaggagc gtctgcaaga agatacgtct tttgggggca acctcgggcg     1200

agcagtcttc caggccaaga agcgggttct cgaacctctc ggtctggttg aggaagctgc     1260

taagacggct cctggaaaga agagaccggt agaaccgtca cctcagcgtt cccccgactc     1320

ctccacgggc atcggcaaga aaggccagca gcccgctaaa aagagactga actttggtca     1380

gactggcgac tcagagtcag tccccgaccc tcaaccaatc ggagaaccac cagcaggccc     1440

ctctggtctg ggatctggta caatggctgc aggcggtggc gctccaatgg cagacaataa     1500

cgaaggcgcc gacggagtgg gtagttcctc aggaaattgg cattgcgatt ccacatggct     1560

gggcgacaga gtcatcacca ccagcacccg aacctgggcc ctgcccacct acaacaacca     1620

cctctacaag caaatatcca atgggacatc gggaggaagc accaacgaca acacctactt     1680

cggctacagc accccctggg ggtattttga cttcaacaga ttccactgcc acttctcacc     1740

acgtgactgg cagcgactca tcaacaacaa ctggggattc cggccaaaaa gactcagctt     1800

caagctcttc aacatccagg tcaaggaggt cacgcagaat gaaggcacca agaccatcgc     1860

caataacctt accagcacga ttcaggtatt tacggactcg gaataccagc tgccgtacgt     1920

cctcggctcc gcgcaccagg gctgcctgcc tccgttcccg gcggacgtct tcatgattcc     1980

ccagtacggc taccttacac tgaacaatgg aagtcaagcc gtaggccgtt cctccttcta     2040

ctgcctggaa tattttccat ctcaaatgct gcgaactgga aacaattttg aattcagcta     2100

caccttcgag gacgtgcctt tccacagcgg ctacgcacac agccagagct tggaccgact     2160

gatgaatcct ctcatcgacc agtacctgta ctacttatcc agaactcagt ccacaggagg     2220

aactcaaggt acccagcaat tgttattttc tcaagctggg cctgcaaaca tgtcggctca     2280

ggctaagaac tggctacctg gaccttgcta ccggcagcag cgagtctcta cgacactgtc     2340

gcaaaacaac aacagcaact ttgcttggac tggtgccacc aaatatcacc tgaacggaag     2400

agactctttg gtaaatcccg gtgtcgccat ggcaacccac aaggacgacg aggaacgctt     2460

cttcccgtcg agtggagtcc tgatgtttgg aaaacagggt gctggaagag acaatgtgga     2520

ctacagcagc gttatgctaa ccagcgaaga agaaattaaa accactaacc ctgtagccac     2580

agaacaatac ggtgtggtgg ctgacaactt gcagcaaacc aatacagggc ctattgtggg     2640

aaatgtcaac agccaaggag ccttacctgg catggtctgg cagaaccgag acgtgtacct     2700

gcagggtccc atctgggcca agattcctca cacggacggc aacttccacc cttcaccgct     2760

aatgggagga tttggactga agcacccacc tcctcagatc ctgatcaaga acacgccggt     2820

acctgcggat cctccaacga cgttcagcca ggcgaaattg gcttccttca ttacgcagta     2880

cagcaccgga caggtcagcg tggaaatcga gtgggagctg cagaaggaga acagcaaacg     2940

ctggaaccca gagattcagt acacttcaaa ctactacaaa tctacaaatg tggactttgc     3000

tgtcaataca gagggaactt attctgagcc tcgccccatt ggtactcgtt acctcacccg     3060

taatctgtaa ttgctggtta atcaataaac cgtttgattc gtttcagttg aactttggtc     3120

tctgcgaagg gcgaattcgt ttaaacctgc aggactagtc cctttagtga gg             3172


<210> 4861
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4861
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg aaagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg agcctgttaa aacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc gagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggatct      600

actacaatgg cttcaggcag tggcgcacca gtggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caagcaaatc      780

tccagccaat caggagcctc aaacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacagct ggggattccg acccaaaaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caagtgttta ccgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttt atggtcccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgctgc gtactggaaa caactttcag ttcagctaca cctttgaaga cgttcccttc     1260

cacagcagct acgctcacag ccagagtctg gatcggctgc tgaatcctct gatcgaccag     1320

tacctatatt atctgaacaa gacacaatca aatagtggaa ctcttcagca gtctcggcta     1380

ctgtttagcc aagctggacc caccagcatg tctcttcaag ctaaaaactg gctgcctgga     1440

ccttgctaca gacagcagcg tctgtcaaag caggcaaacg acaacaacaa cagcaacttt     1500

ccctggactg cggctacaaa gtatcatcta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagccacaa agacgatgaa gaaaagtttt tccccatgca tggaaccctg     1620

atatttggta aacaaggaac aaatgctaac gacgcggatt tggacaatgt catgattaca     1680

gatgaagaag aaatccgcac caccaatccc gtggctacgg agcagtacgg atatgtgtca     1740

aataatttgc aaaactcaaa tactggtcca actactggaa ctgtcaatca ccaaggagcg     1800

ttacctggta tggtgtggca ggatcgagac gtgtacctgc agggacccat ttgggccaag     1860

attcctcaca cggacgggca ctttcatcct tctccactaa tgggaggttt tgggctcaaa     1920

cacccgcctc ctcagatcat gatcaaaaac actcccgttc cagccaatcc tcctacaaac     1980

ttcagttctt ccaagtttgc ttctttcatc acacagtatt ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtat     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ccgactcgta atctgtaa                  2208


<210> 4862
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4862
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Glu Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Ser Gly Ser Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Ser Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Leu Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys Thr 
        435                 440                 445             


Gln Ser Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Asp Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Tyr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ser Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Pro Thr Arg Asn Leu 
                725                 730                 735 


<210> 4863
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4863
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gccaaaaaga ggattcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggagaaaaga ggccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaagaga ttgaattttg gccagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg cttcaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggtattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgcacctg ggccctgccc acctacaaca accatctgta caagcaaatc      780

tccagccagt ctggagccag caacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttctccccac gtgactggca aagactcatc      900

aacaacaact ggggattccg gcccaagaga ctcagcttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggca gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgcttc gtaccggaaa caactttacc ttcagctaca cctttgaaga cgttcctttc     1260

catagcagct acgctcacag ccaaagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgat gtccaggctt     1380

cagttttctc aggccggagc aagtgacatt cgggaccagt ctagaaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acagctgcgg acaacaacaa cagtgattac     1500

tcgtggactg gagctaccaa gtaccacctc aatggaagag actctctggt gaatccgggc     1560

ccagctatgg ccagccacaa ggacgatgaa gaaaaatatt ttcctcagag cggggttctc     1620

atctttggaa aacaagactc gggaaaaact aatgtggaca ttgaaaaggt tatgattaca     1680

gacgaagagg aaatcaggac caccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca gctacctcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagac gtgtacctgc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctcg tgggcggatt cggacttaaa     1920

caccctcctc cacaaattct catcaagaac accccggtac ctgcgaatcc ttcgaccact     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4864
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4864
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Glu Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Ser Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp Tyr Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Met Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Asp Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Asp Ser Gly Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ser Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Val Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4865
<211> 2209
<212> DNA
<213> Adeno-associated virus

<400> 4865
atggctgccg atggttatcc tccagattgg ctcgaggaca ctctctctga agggataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcagagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcggcctgc aagaaaaaga ttaaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggatct      600

actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acatacaaca accacctcta caagcaaatc      780

tccagccaat caggagccag caacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg gcccaaaaga ctcaacttca agctctttaa tattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tgggctcggc gcatcaagga     1080

tgcctcccgc cgtttccagc ggacgtcttc atggtcccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgctgc gtactggaaa caactttcag ttcagctaca cttttgaaga cgtgcctttc     1260

cacagcagct acgctcacag ccagagtctg gatcggctga tgaatcctct gatcgaccag     1320

tacctgtatt atctgaacaa gacacaaaca aatagtggaa ctcttcagca gtctcggcta     1380

ctgtttagcc aagctggacc aaccaacatg tctcttcaag ctaaaaactg gctgcctgga     1440

ccttgctaca gacagcagcg tctgtcaaaa caggcaaacg acaacaacaa cagcaacttt     1500

ccctggactg cagctacaaa gtatcatcta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagtcacaa ggatgacgaa gaaaagtttt tccccatgca tggaaccctg     1620

atatttggta aacaaggaac aaatgccaac gacgcggatt tggaaaatgt catgattaca     1680

gatgaagaag aaatcagggc caccaatccc gtggctacgg agcagtacgg gactgtgtca     1740

aataatttgc aaaactcaaa cactggtcca actactggaa ctgtcaatcg ccaaggagcg     1800

ttacctggta tggtgtggca ggatcgagac gtgtacctgc agggacccat ttgggccaag     1860

attcctcaca ccgatggaca ctttcatcct tctccactga tgggaggttt tggactcaaa     1920

cacccgcctc ctcagatcat gatcaaaaac actcccgttc cagccaatcc tcccacaaac     1980

ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaat                 2209


<210> 4866
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4866
Met Ala Ala Asp Gly Tyr Pro Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Arg Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys Thr 
        435                 440                 445             


Gln Thr Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Asn Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Glu Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Ala Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Thr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Gly Thr Val Asn Arg Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4867
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4867
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aggtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgtcga cgcggagttt      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gccaaaaaga ggattcttga acctctgggc ctggttgagg aacctgttaa ggcggctccg      420

ggagaaaaga ggccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaagaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg cttcaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgcacctg ggccctgccc acctacaaca accatctgta caagcaaatc      780

tccagccagt ctggagccag caacgacaac cactactttg gctacagcac cccctggggg      840

cattttgact tcaacagatt ccactgccac ttctccccac gtgactggca aagactcatc      900

aacaacaact ggggattccg gcccaagaga ctcagcttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggca gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgcttc gtaccggaaa caactttacc ttcagctaca cctttgaaga cgttcctttc     1260

catagcagct acgctcacag ccaaagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgat gtccaggctt     1380

cagttttctc aggccggagc aagtgacatt cgggaccagt ctagaaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acagctgcgg acaacaacaa cagtgattac     1500

tcgtggactg gagctaccaa gtaccacctc aatggaagag actctctggt gaatccgggc     1560

ccagctatgg ccagccacaa ggacgatgaa gaaaaatatt ttcctcagag cggggttctc     1620

atctttggaa aacaagactc gggaaaaact aatgtggaca ttgaaaaggt tatgattaca     1680

gacgaagagg aaatcaggac caccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca gctacctcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagac gtgtacctgc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccccca tgggcggatt cggacttaaa     1920

caccctcctc cacaaattct catcaagaac accccggtac ctgcgaatcc ttcgaccact     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg cgccagatac ctgactcgta atctgtaa                  2208


<210> 4868
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4868
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Arg Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Val 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Ala Ala Pro Gly Glu Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Ser Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly His Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Met Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Asp Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Asp Ser Gly Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ser Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Pro Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Ala Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4869
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4869
atggctgccg atggttatct tccagattgg ctcgaggaca ccctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga taacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagagga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gccaaaaaga ggattcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaagaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccggcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg cttcaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgcacctg ggccctgccc acctacaaca accatctgta caagcaaatc      780

tccagccagt ctggagccag caacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttctccccac gtgactggca aagactcatc      900

aacaacaact ggggattccg gcccaagaga ctcagcttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggca gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgcttc gtaccggaaa caactttacc ttcagctaca cctttgaaga cgttcctttc     1260

catagcagct acgctcacag ccaaagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgat gtccaggctt     1380

cagttttctc aggccggagc aagtgacatt cgggaccagt ctagaaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acagctgcgg acaacaacaa cagtgattac     1500

tcgtggactg gagctaccaa gtaccacctc aatggaagag actctctggt gaatccgggc     1560

ccagctatgg ccagccacaa ggacgatgaa gaaaaatatt ttcctcagag cggggttctc     1620

atctttggaa aacaagactc gggaaaaact aatgtggaca ttgaaaaggt tatgattaca     1680

gacgaagagg aaatcaggac caccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca gctacctcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagac gtgtacctgc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt cggacttaaa     1920

caccctcctc cacaaattct catcaagaac accccggtac ctgcgaatcc ttcgaccact     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4870
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4870
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Arg Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Ser Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Met Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Asp Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Asp Ser Gly Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ser Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4871
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4871
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaaggaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gccaaaaaga ggattcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaagaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg cttcaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcgg cagagtcatc      720

accaccagca cccgcacctg ggccctgccc acctacaaca accatctgta caagcaaatc      780

tccagccagt ctggagccag caacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttctccccac gtgactggca aagactcatc      900

aacaacaact ggggattccg gcccaagaga ctcagcttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggca gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagacgcttc gtaccggaaa caactttacc ttcagctaca cctttgaaga cgttcctttc     1260

catagcagct acgctcacag ccaaagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgat gtccaggctt     1380

cagttttctc aggccggagc aagtgacatt cgggaccagt ctagaaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acagctgcgg acaacaacaa cagtgattac     1500

tcgtggactg gagctaccaa gtaccacctc aatggaagag actctctggt gaatccgggc     1560

ccagctatgg ccagccacaa ggacgatgaa gaaaaatatt ttcctcagag cggggttctc     1620

atctttggaa aacaagactc gggaaaaact aatgtggaca ttgaaaaggt tatgattaca     1680

gacgaagagg aaatcaggac caccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca gctacctcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagac gtgtacctgc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt cggacttaaa     1920

caccctcctc cacaaattct catcaagaac accccggtac ctgcgaatcc ttcgaccact     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4872
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4872
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Gly Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Ser Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Gly Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Thr Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Met Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Asp Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Asp Ser Gly Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ser Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4873
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4873
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gccaaaaaga ggattcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaagaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg cttcaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgcacctg ggccctgccc acctgcaaca accatctgta caagcaaatc      780

tccagccagt ctggagccag caacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttctccccac gtgactggca aagactcatc      900

aacaacaact ggggattccg gcccaagaga ctcagcttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggca gtcaggcggt aggacgctct tccttttact gcctggagta ttttccttct     1200

cagatgcttc gtaccggaaa caactttacc ttcagctaca cctttgaaga cgttcctttc     1260

catagcagct acgctcacag ccaaagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgat gtccaggctt     1380

cagttttctc aggccggagc aagtgacatt cgggaccagt ctagaaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acagctgcgg acaacaacaa cagtgattac     1500

tcgtggactg gagctaccaa gtaccacctc aatggaagag actctctggt gaatccgggc     1560

ccagctatgg ccagccacaa ggacgatgaa gaaaaatatt ttcctcagag cggggttctc     1620

atctttggaa aacaagactc gggaaaaact aatgtggaca ttgaaaaggt tatgattaca     1680

gacgaagagg aaatcaggac caccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

acctacctcc agagcggcaa cacacaagca gctacctcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagac gtgtacctgc gggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt tggacttaaa     1920

caccctcctc cacaaattct catcaagaac accccggtac ctgcgaatcc ttcgaccact     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4874
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4874
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Ser Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Cys Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Met Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Asp Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Asp Ser Gly Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Tyr Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ser Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Arg Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4875
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4875
atggctgccg atggttatct tccagattgg ctcgaggaca ccctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga taacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagagga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gccaaaaaga ggattcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaagaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccggcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg cttcaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgcacctg ggccctgccc acctacaaca accatctgta caagcaaatc      780

tccagccagt ctggagccag caacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttctccccac gtgactggca aagactcatc      900

aacaacaact ggggattccg gcccaagaga ctcagcttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggca gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgcttc gtaccggaaa caactttacc ttcagctaca cctttgaaga cgttcctttc     1260

catagcagct acgctcacag ccaaagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgat gtccaggctt     1380

cagttttctc aggccggagc aagtgacatt cgggaccagt ctagaaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acagctgcgg acaacaacaa cagtgattac     1500

tcgtggactg gagctaccaa gtaccacctc aatggaagag actctctggt gaatccgggc     1560

ccagctatgg ccagccacaa ggacgatgaa gaaaaatatt ttcctcagag cggggttctc     1620

atctttggaa aacaagactc gggaaaaact aatgtggaca ttgaaaaggt tatgattaca     1680

gacgaagagg aaatcaggac caccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca gctacctcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagac gtgtacctgc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt cggacttaaa     1920

caccctcctc cacaaattct catcaagaac accccggtac ctgcgaatcc ttcgaccact     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4876
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4876
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Arg Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Ser Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Met Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Asp Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Asp Ser Gly Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ser Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4877
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4877
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

ggcagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctca acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcaaaaaaga gggttcttga acctctgggc ctggttgagg agcctgttaa aacggctccg      420

ggaaaaaaga gaccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaagaga ttgaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggatct      600

actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accacaagca ctcgaacctg ggccctgccc acctacaaca accacctcta caagcaaatc      780

tccagccaat caggagcctc aaacgacaac cactattttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc ggacgtcttc atggtcccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct cccttttact gcctggagta ctttccttct     1200

cagatgctgc gtactggaaa caactttcag ttcagctaca cttttgaaga cgtgcctttc     1260

cacagcagct acgctcacag ccagagtctg gatcggctga tgaatcctct gatcgaccag     1320

tacctgtatt atctgaacaa gacacaaaca aatagtggaa ctcttcagca gtctcggcta     1380

ctgtttagcc aagctggacc caccaacatg tctcttcaag ctaaaaactg gctgcctgga     1440

ccttgctaca gacagcagcg tctgtcaaag caggcaaacg acaacaacaa cagcaacttt     1500

ccctggactg cagctacaaa gtatcatcta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagtcacaa ggatgacgaa gaaaagtttt tccccatgca tggaaccctg     1620

atatttggta aacaaggaac aaatgccaac gacgcggatt tggaaaatgt catgattaca     1680

gatgaagaag aaatcaggac caccaatccc gtggctacgg agcagtacgg gactgtgtca     1740

aataatttgc aaaactcaaa cactggtcca actactggaa ctgtcaatca ccaaggagcg     1800

ttacctggta tggtgtggca ggatcgagat gtgtaccttc agggacccat ttgggccaag     1860

attcctcaca ccgatggaca ctttcatcct tctccactga tgggaggttt tggactcaaa     1920

cacccgcctc ctcagattat gatcaaaaac actcccgttc cagccaatcc tcctacaaac     1980

ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacaataa tggcgtgtac     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4878
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4878
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Gly Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asn Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Pro Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys Thr 
        435                 440                 445             


Gln Thr Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Asn Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Glu Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Thr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Asn Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4879
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4879
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gccaaaaaga ggattcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaagaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg cttcaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgcacctg ggccctgccc acctacaaca accatctgta caagcaaatc      780

tccagccagt ctggagccag caacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttctccccac gtgactggca aagactcatc      900

aacaacaact ggggattccg gcccaagaga ctcagcttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggca gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgcttc gtaccggaaa caactttacc ttcagctaca cctttgaaga cgttcctttc     1260

catagcagct acgctcacag ccaaagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgat gtccaggctt     1380

cagttttctc aggccggagc aagtgacatt cgggaccagt ctagaaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acagctgcgg acaacaacaa cagtgattac     1500

tcgtggactg gagctaccaa gtaccacctc aatggaagag actctctggt gaatccgggc     1560

ccagctatgg ccagccacaa ggacgatgaa gaaaaatatt ttcctcagag cggggttctc     1620

atctttggaa aacaagactc gggaaaaact aatgtggaca ttgaaaaggt tatgattaca     1680

gacgaagagg aaatcaggac caccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca gctacctcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagac gtgtacctgc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt cggacttaaa     1920

caccctcctc cacaaattct catcaagaac accccggtac ctgcgaatcc ttcgaccact     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4880
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4880
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Ser Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Met Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Asp Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Asp Ser Gly Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ser Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4881
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4881
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gccaaaaaga ggattcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaagaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg cttcaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgcacctg ggccctgccc acctacaaca accatctgta caagcaaatc      780

tccagccagt ctggagccag caacgacaac cactactttg gctacagcac cccctggggg      840

tatttcgact tcaacagatt ccactgccac ttctccccac gtgactggca aagactcatc      900

aacaacaact ggggattccg gcccaagaga ctcagcttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcggg gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgccttccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggca gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgcttc gtaccggaaa caactttacc ttcagctaca cctttgaaga cgttcctttc     1260

catagcagct acgctcacgg ccaaagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgat gtccaggctt     1380

cagttttctc aggccggagc aagtgacgtt cgggaccagt ctagaaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acagctgcgg acaacaacaa cagtgattac     1500

tcgtggactg gagctaccaa gtaccacctc aatggaagag actctctggt gaatccgggc     1560

ccagctatgg ccagccacaa ggacgatgaa gaaaaatatt ttcctcagag cggggttctc     1620

gtctttggaa aacaagactc gggaaaaact aatgtggaca ttgaaaaggt tatgattaca     1680

gacgaagagg aaatcaggac caccaatccc gcggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca gctacctcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagac gtgtacctgc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt cggacttaaa     1920

caccctcctc cacaaattct catcaagaac accccggtac ctgcgaatcc ttcgaccact     1980

ttcagtgcgg caaagtttgt ttccttcatc acacagtact ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4882
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4882
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Ser Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Gly Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Gly Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Met Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Val Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Asp Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Gln Ser Gly Val Leu Val Phe Gly Lys 
    530                 535                 540                 


Gln Asp Ser Gly Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Ala Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ser Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Val Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4883
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4883
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga aactcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcaaaaaaga gggttctgga acctctgagc ctggttgagg agcctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctccc gcagagccag attcctcctc cggaactgga      480

aagtcgggca accagcctgc aagaaagaga ttgaatttcg gtcagactgg agactcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accatctgta caagcaaata      780

tccagccagt ctggagccag caacgacaat cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctagagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cctttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtttg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgca gtccaggctt     1380

cagttttctc aggccggagc gagtgacatt caggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gtcagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg ccagccacaa agacgatgaa gaaaagtttt ttcctcagag cggggttctt     1620

atctttggga agcaaggctc agagaaaaca aatgtggata ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac caccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtcgggca agacagagac gtgtacctgc aggggcctac ttgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt tggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatt acacagtact ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga gatccagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4884
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4884
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Ser Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ser Gly Asn Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Gln Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Gly Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Thr Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4885
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4885
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcagagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcaaaaaaga gggttctgga acctctgggc ctggttgagg agcctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gcagagccag attcctcctc cggaactgga      480

aagtcgggca accagcctgc aagaaagaga ttgaatttcg gtcagactgg agactcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accatctgta caagcaaata      780

tccagccagt ctggagccag caacgacaat cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctagggta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cctttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtttg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgca gtccaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gtcagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg ccagccacaa agacgatgaa gaaaagtttt ttcctcagag cggggttctt     1620

atctttggga agcaaggccc agagaaaaca aatgtggata ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac caccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca agacagagac gtgtacctgc aggggcctat ttgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt tggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatt acacagtact ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga gatccagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4886
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4886
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ser Gly Asn Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Gly Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Pro Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4887
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4887
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ser Gly Asn Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Pro Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4888
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4888
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ser Gly Asn Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Pro Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4889
<211> 2211
<212> DNA
<213> Adeno-associated virus

<400> 4889
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcagagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgcgg cctggtttga ggaaacctgt taagacggct      420

ccgggaaaaa agaggccggt agagcactct cctgtggagc cagactcctc ctcgggaacc      480

ggaaaagcgg gccagcagcc tgcaagaaaa agattaaatt ttggtcagac tggagacgca      540

gactccgtac ctgaccccca gcctctcgga cagccaccag cagccccctc tggtctggga      600

tctactacaa tggctacagg cagtggcgca ccaatggcag acaataacga gggtgccgat      660

ggagtgggta attcctcagg aaattggcat tgcgattccc aatggctgga cgacagagtc      720

atcgccacca gcacccgaac ctgggccctg cccacataca acaaccacct ctacaagcaa      780

atctccagcc aatcaggagc ctgcaacgac aaccactact ttggctacag caccccctgg      840

gggtattttg acttcaacag attccactgc cacttttcac cacgtgactg gcaaagactc      900

atcaacagca actggggatt ccggcccaaa agactcaact tcaagctctt taatattcaa      960

gtcaaagagg tcacgcagaa tgacggtacg acgacgattg ccaataacct taccagcacg     1020

gttcaggtgt ttactgactc ggagtaccag ctcccgtacg tcccgggctc ggcgcatcaa     1080

ggatgcctcc cgccgtttcc agcggacgtc ttcatggtcc cacagtatgg atacctcacc     1140

ctgaacaacg ggagtcaggc ggtaggacgc tcttcctttt actgcctgga gtactttcct     1200

tctcagatgc tgcgtactgg aaacaacttt cagttcagct acacttttga agacgtgcct     1260

ttccacagca gctacgctca ctgccagagt ctggatcggc tgatgaatcc tctgatcgac     1320

cagtacctgt attatctgaa caagacacaa acaaatagtg gaactcttca gcagtctcgg     1380

ctactgttta gccaagctgg accaaccaac atgtctcttc aagctaaaaa ctggctgcct     1440

ggaccttgct acagacagca gcgtctgtca aaacaggcaa acgacaataa caactgcaac     1500

tttccctgga ctgcagctac aaagtatcat ctaaatggcc gggactcgtt ggttaatcca     1560

ggaccagcta tggccagtca caaggatgac gaagaaaagt ttttccccat gcatggaacc     1620

ctgatatttg gtaaacaagg aacaaatgcc aacgacgcgg atttggaaaa tgtcatgatt     1680

acagatgaag aagaaatcag gcccaccaat cccgtggcta cggagcagta cgggactgtg     1740

tcaaataatt tgcaaaactc aaacactggt ccaactacag gaactgtcaa tcaccaagga     1800

gcgttacctg gtatggtgtg gcaggatcga gacgtgtacc tgcagggacc catttgggcc     1860

aagattcctc acaccgatgg acactttcat ccttctccac tgatgggagg ttttggactc     1920

aaacacccgc ctcctcagat catgatcaaa agcactcccg ttccagccaa tcctcccaca     1980

aacttcagtt ctgccaagtt tgcttcttcc atcacacagt attccacggg acaggtcagc     2040

gtggagatcg agtgggagct gcagaaggag aacagcaaac gctggaatcc cgaaattcag     2100

tacacttcca actacaacaa gtctgttaat gtggacttta ctgtggacac taatggtgtg     2160

tattcagagc ctcgccccat tggcaccaga tacctgactc gtaatctgta a              2211


<210> 4890
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 4890
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Arg Pro Gly Leu Arg Lys Pro Val Lys Thr Ala Pro Gly Lys Lys 
    130                 135                 140                 


Arg Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr 
145                 150                 155                 160 


Gly Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Thr Gly Ser 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Asp Asp Arg Val 
225                 230                 235                 240 


Ile Ala Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Cys Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Ser Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Pro Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Cys Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys 
        435                 440                 445             


Thr Gln Thr Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Thr Asn Met Ser Leu Gln Ala Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Cys Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Glu Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr 
            580                 585                 590         


Thr Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Ser Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Ser Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 4891
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4891
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagagga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcaaaaaaga gggttctgga acctctgggc ctggttgagg agcctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gcagagccag attcctcctc cggaactgga      480

aagtcgggca accagcctgc aagaaagaga ttgaatttcg gtcagactgg agactcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accatctgta caagcaaata      780

tccagccagt ctggagccag caacgacaat cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctagagta ctttccttct     1200

cagatgctgc gtaccggaaa cagctttacc ttcagctaca cctttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtttg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgca gtccaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gtcagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg ccagccacaa agacgatgaa gaaaagttct ttcctcagag cggggttctt     1620

atctttggga agcaaggctc agagaaaaca aatgtggata ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac caccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca agacagagac gtgtacctgc aggggcctat ttgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt tggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatt acacagtact ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga gatccagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4892
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4892
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ser Gly Asn Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Ser Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4893
<211> 2211
<212> DNA
<213> Adeno-associated virus

<400> 4893
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctccgc gggtattggc      480

aaatcgggtg cacagcccgc taaaaagaga ctcaatttcg gtcagactgg cgacacagag      540

tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca gtggcagaca ataacgaagg tgccgatgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgccacttct caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggcct aagcgactca acttcaagct cttcaacatt      960

caggtcaaag aggttacgga caacaatgga gtcaagacca tcgccaataa ccttaccagc     1020

acggtccagg tcttcacgga ctcagactat cagctcccgt acgtgctcgg gtcggctcac     1080

gagggctgcc tcccgccgtt cccagcggac gttttcatga ttcctcagta cgggtatctg     1140

acgcttaatg atggaagcca ggccgtgggt cgttcgtcct tttactgcct ggaatatttc     1200

ccgtcgcaaa tgctaagaac gggtaacaac ttccagttca gctacgagtt tgagaacgta     1260

cctttccata gcagctacgc tcacagccaa agcctggacc gactaatgaa tccactcatc     1320

gaccaatact tgtactatct ctcaaagact attaacggtt ctggacagaa tcaacaaacg     1380

ctaaaattca gtgtggccgg acccagcaac atggctgtcc agggaagaaa ctacatacct     1440

ggacccagct accgacaaca acgtgtctca accactgtga ctcaaaacaa caacagcgaa     1500

tttgcttggc ctggagcttc ttcttgggct ctcaatggac gtaatagctt gatgaatcct     1560

ggacctgcta tggccagcca caaagaagga gaggaccgtt tctttccttt gtctggatct     1620

ttaatttttg gcaaacaagg aactggaaga gacaacgtgg atgcggacaa agtcatgata     1680

accaacgaag aagaaattaa aactactaac ccggtagcaa cggagtccta tggacaagtg     1740

gccacaaacc accagagtgc ccaagcacag gcgcagaccg gctgggttca aaaccaagga     1800

atacttccgg gtatggtttg gcaggacaga gatgtgtacc tgcaaggacc catttgggcc     1860

aaaattcctc acacggacgg caactttcac ccttctccgc tgatgggagg gtttggaatg     1920

aagcacccgc ctcctcagat cctcatcaaa aacacacctg tacctgcgga tcctccaacg     1980

gccttcaaca aggacaagct gaactctttc atcacccagt attctactgg ccaagtcagc     2040

gtggagatcg agtgggagct gcagaaggaa aacagcaagc gctggaaccc ggagatccag     2100

tacacttcca actattacaa gtctaataat gttgaatttg ctgttaatac tgaaggtgta     2160

tatagtgaac cccgccccat tggcaccaga tacctgactc gtaatctgta a              2211


<210> 4894
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 4894
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ser Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Gly Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Ser Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 4895
<211> 2211
<212> DNA
<213> Adeno-associated virus

<400> 4895
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctccgc gggtattggc      480

aaatcgggtt cacagcccgc taaaaagaaa ctcaatttcg gtcagactgg cgacacagag      540

tcagtccccg accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca gtggcagaca ataacgaagg tgccgatgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgccacttct caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggcct aagcgactca acttcaagct cttcaacatt      960

caggtcaaag aggttacgga caacaatgga gtcaagacca tcgccaataa ccttaccagc     1020

acggtccagg tcttcacgga ctcagactat cagctcccgt acgtgctcgg gtcggctcac     1080

gagggctgcc tcccgccgtt cccagcggac gttttcatga ttcctcagta cgggtatctg     1140

acgcttaatg atgggagcca ggccgtgggt cgttcgtcct tttactgcct ggaatatttc     1200

ccgtcgcaaa tgctaagaac gggtaacaac ttccagttca gctacgagtt tgagaacgta     1260

cctttccata gcagctacgc tcacagccaa agcctggacc gactaatgaa tccactcatc     1320

gaccaatact tgtactatct ctcaaagact attaacggtt ctggacagaa tcaacaaacg     1380

ctaaaattca gcgtggccgg acccagcaac atggctgtcc agggaagaaa ctacatacct     1440

ggacccagct accgacaaca acgtgtctca accactgtga ctcaaaacaa caacagcgaa     1500

tttgcttggc ctggagcttc ttcttgggct ctcaatggac gtaatagctt gatgaatcct     1560

ggacctgcta tggccagcca caaagaagga gaggaccgtt tctttccttt gtctggatct     1620

ttaatttttg gcaaacaagg aactggaaga gacaacgtgg atgcggacaa agtcatgata     1680

accaacgaag aagaaattaa aactactaac ccggtagcaa cggagtccta tggacaagtg     1740

gccacaaacc accagagtgc ccaagcacag gcgcagaccg gctgggttca aaaccaagga     1800

atacttccgg gtatggtttg gcaggacaga gatgtgtacc tgcaaggacc catttgggcc     1860

aaaattcctc acacggacgg caactttcac ccttctccgc taatgggagg gtttggaatg     1920

aagcacccgc ctcctcagat cctcatcaaa aacacacctg tacctgcgga tcctccaacg     1980

gctttcaata aggacaagct gaactctttc atcacccagt attctactgg ccaagtcagc     2040

gtggagattg agtgggagct gcagaaggaa aacagcaagc gctggaaccc ggagatccag     2100

tacacttcca actattacaa gtctaataat gttgaatttg ctgttaatac tgaaggtgta     2160

tatagtgaac cccgccccat tggcaccaga tacctgactc gtaatctgta a              2211


<210> 4896
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 4896
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ser Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 4897
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4897
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagcggtgga agctcaaacc tggcccacca ccaccagagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggtacttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cggcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg ggccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4898
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4898
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Arg Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Glu Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Gly Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Gly Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4899
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4899
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagcggtgga agctcaaacc tggcccacca ccaccagagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtccttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggtacttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacgaga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg ggccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4900
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4900
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Arg Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Glu Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Glu Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Gly Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4901
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4901
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagcggtgga agctcaaacc tggcccacca ccaccagagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggtacttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtaccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg ggccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4902
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4902
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Arg Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Glu Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Gly Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4903
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4903
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagcggtgga agctcaaacc tggcccacca ccaccagagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggtactcga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagc aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg ggccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc cgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4904
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4904
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Arg Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Glu Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Ala Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Gly Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4905
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4905
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4906
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 4906
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctaaaaag agactgaact ttggtcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atatccaatg ggacatcggg aggaagcacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt caacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg ccaaaaagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taaccttacc     1020

agcacgattc aggtatttac ggactcggaa taccagctgc cgtacgtcct cggctccgcg     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcccca gtacggctac     1140

cttacactga acaatggaag tcaagccgta ggccgttcct ccttctactg cctggaatat     1200

tttccatctc aaatgctgcg aactggaaac aattttgaat tcagctacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcacacagc cagagcttgg accgactgat gaatcctctc     1320

atcgaccagt acctgtacta cttatccaga actcagtcca caggaggaac tcaaggtacc     1380

cagcaattgt tattttctca agctgggcct gcaaacatgt cggctcaggc taagaactgg     1440

ctacctggac cttgctaccg gcagcagcga gtctctacga cactgtcgca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa tatcacctga acggaagaga ctctttggta     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccgtcgagt     1620

ggagtcctga tgttcggaaa acagggtgct ggaagagaca atgtggacta cagcagcgtt     1680

atgctaacca gcgaagaaga aattaaaacc actaaccccg tagccacaga acaatacggt     1740

gtggtggctg acaacttgca gcaaaccaat acagggccta ttgtgggaaa tgtcaacagc     1800

caaggagcct tacctggcat ggtctggcag aaccgagacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccaccctt caccgctaat gggaggattt     1920

ggactgaagc acccacctcc tcagatcctg atcaagaaca cgccggtacc tgcggatcct     1980

ccaacaacgt tcagccaggc gaaattggct tccttcatta cgcagtacag caccggacag     2040

gtcagcgtgg aaatcgagtg ggagctgcag aaggagaaca gcaaacgctg gaacccagag     2100

attcagtaca cttcaaacta ctacaaatct acaaatgtgg actttgctgt caatacagag     2160

ggaacttatt ctgagcctcg ccccattggt actcgttacc tcacccgtaa tctgtaa        2217


<210> 4907
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4907
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Cys His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4908
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4908
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Arg 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Leu Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Ala Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Pro Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Arg Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Thr Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Ala Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Ala Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4909
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 4909
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcggac tggcgactca      540

gagtcagtcc ccgaccctca acctatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtt      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacctcggg aggcagcacc aacgacaaca cctactttgg ctacagcacc      840

ccctgggggt atcttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcgcc     1020

agcaccatcc aggtgtttac ggactcggaa taccagccgc cgtacgtcct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcctca gtacggctac     1140

ctgactctca acaacggtag tcaggccgtg ggacgttcct ccttctactg cctggagtac     1200

ttcccctctc agatgctgag aacgggcaac aacttttcct tcagctacac tttcgaggac     1260

gtgcctttcc acagcagcta cgcgcacagc cagagtttgg acaggctgat gaatcctctc     1320

atcgaccagt acctgtacta cctgtcaaga acccagtcta cgggaggcac agcgggaacc     1380

cagcagttgc tgttttctcg ggccgggcct agcaacatgt cggctcaggc cagaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga acggcagaga ctctctggtg     1560

aatccgggcg tcgccatggc aaccaacaag gacgacgagg accgcttctt cccatccagc     1620

ggcatcctca tgtttggcaa gcagggagct ggaaaagaca acgtggacta tagcaacgtg     1680

atgctaacca gcgaggaaga aatcaagacc accaaccccg tggccacaga acagtatggc     1740

gtggtggctg ataacctaca gcagcaaaac accgctccta ctgtgggggc cgtcaacagc     1800

cagggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatt     1860

tgggccaaga ttcctcacac agatggcaac tttcacccgt ctcctttaat gggcggcttt     1920

ggacttaaac atccgcctcc tcagatcctc atcaaaaaca ctcctgttcc tgcggatcct     1980

ccaacagcgt tcaaccaggc caagctgaat tctttcatcg cgcagtacag caccggacaa     2040

gtcagcgtgg agatcgagtg ggagctgcag aaggagaaca gcaagcgctg gaacccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgcgg actttgctgt taatactgag     2160

ggtgtttact ctgagcctcg ccccattggc actcgttacc tcacccgtaa tctgtaa        2217


<210> 4910
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4910
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcagagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg agcctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaaaaga ttaaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggatct      600

actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acatacaaca accacctcta caagcaaatc      780

tccagccaat caggagccag caacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcgtc      900

aacaacaacc ggggattccg gcccaaaaga ctcaacttca agctctttaa tattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tgggctcggc gcatcaagga     1080

tgcctcccgc cgtttccagc ggacgtcttc atggtcccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgctgc gtactggaaa caactttcag ttcagctaca cttttgaaga cgtgcctttc     1260

cacagcagct acgctcacag ccagagtctg gatcggctga tgaatcctct gatcgaccag     1320

tacctgtatt atctgaacaa gacacaaaca aatagtggaa ctcttcagca gtctcggcta     1380

ctgtttagcc aagctggacc aaccaacatg tctcttcaag ctaaaaactg gctgcctgga     1440

ccttgctaca gacagcagcg tctgtcaaaa caggcaaacg acaacaacaa cagcaacttt     1500

ccctggactg cagctacaaa gtatcatcta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagtcacaa ggatgacgaa gaaaagtttt tccccatgca tggaaccctg     1620

atatttggta aacaaggaac aaatgccaac gacgcggatt tggaaaatgt catgattaca     1680

gatgaagaag aaatcagggc caccaatccc gtggctacgg agcagtacgg gactgtgtca     1740

aataatttgc aaaactcaaa cactggtcca actactggaa ctgtcaatca ccaaggagcg     1800

ttacctggta tggtgtggca ggatcgagac gtgtacctgc agggacccat ttgggccaag     1860

attcctcaca ccgatggaca ctttcatcct tctccactga tgggaggttt tggactcaaa     1920

cacccgcctc ctcagatcat gatcaaaaac actcccgttc cagccaatcc tcccacaaac     1980

ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4911
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4911
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Val Asn Asn Asn Arg 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys Thr 
        435                 440                 445             


Gln Thr Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Asn Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Glu Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Ala Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Thr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4912
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4912
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Ser Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Ser Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4913
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 4913
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctaaaaag agactgagct ttggtcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atatccaatg ggacatcggg aggaagcacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt caacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg ccaaaaagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taaccttacc     1020

agcacgattc aggtatttac ggactcggaa taccagctgc cgtacgtcct cggctccgcg     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcccca gtacggctac     1140

cttacactga acaatggaag tcaagccgta ggccgttcct ccttctactg cctggaatat     1200

tttccatctc aaatgctgcg aactggaaac aattctgaat tcagctacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcacacagc cagagcttgg accgactgat gaatcctctc     1320

atcgaccagt acctgtacta cttatccaga actcagtcca caggaggaac tcaaggtacc     1380

cagcaattgt tattttctca agctgggcct gcaaacatgt cggctcaggc taagaactgg     1440

ctacctggac cttgctaccg gcagcagcga gtctctacga cactgtcgca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa tatcacctga acggaagaga ctctttggta     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccgtcgagt     1620

ggagtcctga tgtttggaaa acagggtgct ggaagagaca atgtggacta cagcagcgtt     1680

atgctaacca gcgaagaaga aattaaaacc actaaccctg tagccacaga acaatacggt     1740

gtggtggctg acaacttgca gcaaaccaat acagggccta ttgtgggaaa tgtcaacagc     1800

caaggagcct tacctggcat ggtctggcag aaccgagacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccaccctt caccgctaat gggaggattt     1920

ggactgaagc acccacctcc tcagatcctg atcaagaaca cgccggtacc tgcggatcct     1980

ccaacaacgt tcagccaggc gaaattggct tccttcatta cgcagtacag caccggacag     2040

gtcagcgtgg aaatcgagtg ggagctgcag aaggagaaca gcaaacgctg gaacccagag     2100

attcagtaca cttcaaacta ctacaaatct acaaatgtgg actttgctgt caatacagag     2160

ggaacttatt ctgagcctcg ccccattggt actcgttacc tcacccgtaa tctgtaa        2217


<210> 4914
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4914
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Pro Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Pro Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Val Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4915
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 4915
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tacaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ccggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgccacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctaaaaag agactgaact ttggtcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atatccaatg ggacatcggg aggaagcacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt caacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg ccaaaaagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccgtcgccaa taaccttacc     1020

agcacgattc aggtatttac ggactcggaa taccagctgc cgtacgtcct cggctccgcg     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcccca gtacggctac     1140

cttacactga acaatggaag tcaagccgta ggccgttcct ccttctactg cctggaatat     1200

tttccatctc aaatgctgcg aactggaaac aattttgaat tcagctacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcacacagc cagagcttgg accgactgat gaatcctctc     1320

atcgaccagt acctgtacta cttatccaga actcagtcca caggaggaac tcaaggtacc     1380

cagcaattgt tattttctca agctgggcct gcaaacatgt cggctcaggc taagaactgg     1440

ctacctggac cttgctaccg gcagcagcga gtctctacga cactgtcgca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa tatcacctga acggaagaga ctctttggta     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccgtcgagt     1620

ggagtcctga tgtttggaaa acagggtgct ggaagagaca atgtggacta cagcagcgtt     1680

atgctaacca gcgaagaaga aattaaaacc actaaccctg tagccacaga acaatacggt     1740

gtggtggctg acaacttgca gcaaaccaat acagggccta ttgtgggaaa tgtcaacagc     1800

caaggagcct tacctggcat ggtctggcag aaccgagacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccaccctt caccgctaat gggaggattt     1920

ggactgaagc acccacctcc tcagatcctg atcaagaaca cgccggtacc tgcggatcct     1980

ccaacaacgt tcagccaggc gaaattggct tccttcatta cgcagtacag caccggacag     2040

gtcagcgtgg aaatcgagtg ggagctgcag aaggagaaca gcaaacgttg gaacccagag     2100

attcagtaca cttcaaacta ctacaaatct acaaatgtgg actttgctgt caatacagag     2160

ggaacttatt ctgagcctcg ccccattggt actcgttacc tcacccgtaa tctgtaa        2217


<210> 4916
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4916
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Ser Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Leu 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4917
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 4917
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctaaaaag agactgaact ttggtcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atatccaatg ggacatcggg aggaagcacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt caacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg ccaaaaagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taaccttacc     1020

agcacgattc aggtatttac ggactcggaa taccagctgc cgtacgtcct cggctccgcg     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcccca gtacggctac     1140

cttacactga acaatggaag tcaagccgta ggccgttcct ccttctactg cctggaatat     1200

tttccatctc aaatgctgcg aactggaaac aattttgaat tcagctacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcacacagc cagagcttgg accgactgat gaatcctctc     1320

atcgaccagt acctgtacta cttatccaga actcagtcca caggaggaac tcaaggtacc     1380

cagcaattgt tattttctca agctgggcct gcaaacatgt cggctcaggc taagaactgg     1440

ctacctggac cttgctaccg gcagcagcga gtctctacga cactgtcgca aagcaacaac     1500

agcaactttg cttggactgg tgccaccaaa tatcacctga acggaagaga ctctttggta     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccgtcgagt     1620

ggagtcctga tgtttggaaa acagggtgct ggaagagaca atgtggacta cagcagcgtt     1680

atgctaacca gcgaagaaga aattaaaacc actaaccctg tagccacaga acaatacggt     1740

gtggtggctg acaacttgca gcaaaccaat acagggccta ttgtgggaaa tgtcaacagc     1800

caaggagcct tacctggcat ggtctggcag aaccgagacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccaccctt caccgctaat gggaggactt     1920

ggactgaagc acccacctcc tcagatcctg atcaagaaca cgccggtacc tgcggatcct     1980

ccaacaacgt tcagccaggc gaaattggct tccttcatta cgcagtacag caccggacag     2040

gtcagcgtgg aaatcgagtg ggagctgcag aaggagaaca gcaaacgctg gaacccagag     2100

attcagtaca cttcaaacta ctacaaatct acaaatgtgg actttgctgt caatacagag     2160

ggaacttatt ctgagcctcg ccccattggt actcgttacc tcacccgtaa tctgtaa        2217


<210> 4918
<211> 737
<212> PRT
<213> Adeno-associated virus

<400> 4918
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Pro Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Pro Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn 
            260                 265                 270         


His Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Glu Val Pro Leu His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Val Gln Tyr Leu Tyr Tyr Leu Asn 
        435                 440                 445             


Arg Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe 
    450                 455                 460                 


Ser Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp 
                485                 490                 495     


Asn Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu 
            500                 505                 510         


Asn Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His 
        515                 520                 525             


Lys Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe 
    530                 535                 540                 


Gly Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met 
545                 550                 555                 560 


Ile Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Arg Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro 
            580                 585                 590         


Ala Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Ala Lys Ser Ala Ser Val Asp Phe Thr Val Asp Asn Asn Gly 
705                 710                 715                 720 


Leu Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro 
                725                 730                 735     


Leu 
    


<210> 4919
<211> 737
<212> PRT
<213> Adeno-associated virus

<400> 4919
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Pro Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn 
            260                 265                 270         


His Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Glu Val Pro Leu His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn 
        435                 440                 445             


Arg Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe 
    450                 455                 460                 


Ser Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp 
                485                 490                 495     


Asn Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu 
            500                 505                 510         


Asn Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His 
        515                 520                 525             


Lys Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe 
    530                 535                 540                 


Gly Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met 
545                 550                 555                 560 


Ile Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Arg Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro 
            580                 585                 590         


Ala Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Ala Lys Ser Ala Ser Val Asp Phe Thr Val Asp Asn Asn Gly 
705                 710                 715                 720 


Leu Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro 
                725                 730                 735     


Leu 
    


<210> 4920
<211> 2214
<212> DNA
<213> Adeno-associated virus

<400> 4920
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ccgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgcctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctaaaaag agactgaact ttggtcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta atgcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgcac ctgggccttg cccacctaca ataaccacct ctacaagcaa      780

atctccagtg cttcaacggg ggccagcaac gacaaccact acttcggcta cagcaccccc      840

tgggggtatt ttgatttcaa cagattccac tgccactttt caccacgtga ctggcagcga      900

ctcatcaaca acaattgggg attccggccc aagagactca acttcaaact cttcaacatc      960

caagtcaagg aggtcacgac gaatgatggc gtcacaacca tcgctaataa ccttaccagc     1020

acggttcaag tcttctcgga ctcggagtac cagcttccgt acgtcctcgg ctctgcgcac     1080

cagggctgcc tccctccgtt cccggcggac gtgttcatga ttccgcaata cggctacctg     1140

acgctcaaca atggcagcca agccgtggga cgttcatcct tttactgcct ggaatatttc     1200

ccttctcaga tgctgagaac gggcaacaac tttaccttca gctacacctt tgaggaagtg     1260

cctctccaca gcagctacgc gcacagccag agcctggacc ggctgatgaa tcctctcatc     1320

gtccaatacc tgtattacct gaacagaact caaaatcagt ccggaagtgc ccaaaacaag     1380

gacttgctgt tcagccgtgg gtctccagct ggcatgtctg ttcagcccaa aaactggcta     1440

cctggaccct gttatcggca gcagcgcgtt tctaaaacaa aaacagacaa caacaacagc     1500

aattttacct ggactggtgc ttcaaaatat aacctcaatg ggcgtgaatc catcatcaac     1560

cctggcactg ctatggcctc acacaaagac gacgaagaca agttctttcc catgagcggt     1620

gtcatgattt ttggaaaaga gagcgccgga gcttcaaaca ctgcattgga caatgtcatg     1680

attacagacg aagaggaaat taaagccact aaccctgtgg ccaccgaaag atttgggacc     1740

gtggcagtca atttccagag cagcagcaca gaccctgcga ccggagatgt gcatgctatg     1800

ggagcattac ctggcatggt gtggcaagat agagacgtgt acctgcaggg tcccatttgg     1860

gccaaaattc ctcacacaga tggacacttt cacccgtctc ctcttatggg cggctttgga     1920

ctcaagaacc cgcctcctca gatcctcatc aaaaacacgc ctgttcctgc gaatcctccg     1980

gcggagtttt cagctacaaa gtttgcttca ttcatcaccc aatactccac aggacaagtg     2040

agtgtggaaa ttgaatggga gctgcagaaa gaaaacagca agcgctggaa tcccgaagtg     2100

cagtacacat ccaattatgc aaaatctgcc agcgttgatt ttactgtgga caacaatgga     2160

ctttatactg agcctcgccc cattggcacc cgttacctta cccgtcccct gtaa           2214


<210> 4921
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 4921
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Arg Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Glu Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Gly Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Pro Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Gly Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 4922
<211> 2211
<212> DNA
<213> Adeno-associated virus

<400> 4922
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcagacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctga gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagggccag actcctcctc gggcatcggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg atccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgcacctg ggccttgccc acctacaata accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc cacttttcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaaactctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acaaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag cttccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcaatacgg ctacctgacg     1140

ctcaacaatg gcagccaagc cgtgggacgt tcatcctttt actgcctgga atatttccct     1200

tctcagatgc tgagaacggg caacaacttt accttcagct acacctttga ggaagtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

caatacctgt attacccgaa cagaactcaa aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgtgggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaat     1500

tttacctgga ctggtgcttc aaaatataac ctcaatgggc gtgaatccat catcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaagagag cgccggagct tcaaacactg cattggacaa tgtcatgatt     1680

acagacgaag aggaaattaa agccactaac cctgtggcca ccgaaagatt tgggaccgtg     1740

gcagtcaatt tccagagcag cagcacagac cctgcgaccg gagatgtgca tgctatggga     1800

gcattacctg gcatggtgtg gcaaggtaga gacgtgtacc tgcagggtcc catttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccaat actccacagg acaagtgagt     2040

gtggaaattg aatgggagct gcagaaagaa aacagcaagc gctggaatcc cgaagtgcag     2100

tacacatcca attatgcaaa atctgccaac gttgatttta ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt taccttaccc gtcccctgta a              2211


<210> 4923
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 4923
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Arg Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Gly Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Pro Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Gly Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 4924
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 4924
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Arg Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Gly Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Gly Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 4925
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 4925
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Arg Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Gly Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 4926
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4926
atggctgccg atggctatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcatagggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcggg gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata ccccaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcac aacaaacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccgtgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4927
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4927
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Arg Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Gly Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Pro Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Thr Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Val Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4928
<211> 2211
<212> DNA
<213> Adeno-associated virus

<400> 4928
atggctgccg acggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcgggcgggc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actccccctc gggcatcggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg atccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcactgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgcacctg ggccttgccc acctacaata accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc cacttttcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaaactctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acaaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag cttccgtacg tcctcggctc tgcgcaccag     1080

ggccgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcaatacgg ctacctgacg     1140

ctcaacaatg gcagccaagc cgtgggacgt tcatcctctt actgcctgga atatttccct     1200

tctcagatgc tgagaacggg caacaacttt accttcagct acacctttga ggaagtgcct     1260

ctccacagca gctgcgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

caatacctgt attacctgaa cagaactcaa aatcagtccg gaagtgccca aaacagggac     1380

ttgctgttca gccgtgggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaat     1500

tttacctgga ctggtgcttc aaaatataac ctcaatgggc gtgaatccat catcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaagagag cgccggagct tcaaacactg cattggacaa tgtcatgatt     1680

acagacgaag aggaaattaa agccactaac cctgtggcca ccgaaagatt tgggaccgtg     1740

gcagtcaatt tccagagcag cagcacagac cctgcgaccg gagatgtgca tgctatggga     1800

gcattacctg gcatggtgtg gcaagataga gacgtgtacc tgcagggtcc catttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccaat actccgcagg acaagtgagt     2040

gtggaaattg aatgggagct gcagaaagaa aacagcaagc gctggaatcc cgaagtgcag     2100

tacacatcca attatgcaaa atctgccaac gttgatttta ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt taccttaccc gtcccctgta a              2211


<210> 4929
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 4929
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Pro Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Arg Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Ser Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Leu His Ser Ser Cys Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Arg Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Ala Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 4930
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 4930
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Leu His Ser Ser Cys Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Arg Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 4931
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4931
atggctgccg atggctatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcatagggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgggg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacagt cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcac aacaaacact ccaagtggaa ccaccacgca gtcaaggctc     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacaatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4932
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4932
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Arg Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Gly Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Ser His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Thr Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asn Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4933
<211> 737
<212> PRT
<213> Adeno-associated virus

<400> 4933
Arg Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu 
1               5                   10                  15      


Ser Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys 
            20                  25                  30          


Pro Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu 
        35                  40                  45              


Pro Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu 
    50                  55                  60                  


Pro Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr 
65                  70                  75                  80  


Asp Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His 
                85                  90                  95      


Ala Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly 
            100                 105                 110         


Gly Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu 
        115                 120                 125             


Pro Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys 
    130                 135                 140                 


Arg Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile 
145                 150                 155                 160 


Gly Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Thr Ser Thr Gly Ala Ser Asn Asp Asn 
            260                 265                 270         


His Tyr Phe Gly Tyr Gly Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Glu Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn 
        435                 440                 445             


Arg Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe 
    450                 455                 460                 


Ser Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp 
                485                 490                 495     


Asn Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu 
            500                 505                 510         


Asn Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Val Ala Ser His 
        515                 520                 525             


Lys Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe 
    530                 535                 540                 


Gly Lys Glu Ser Ala Gly Ala Ser Ser Thr Ala Leu Asp Asn Val Met 
545                 550                 555                 560 


Ile Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Arg Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro 
            580                 585                 590         


Ala Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly 
705                 710                 715                 720 


Leu Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro 
                725                 730                 735     


Leu 
    


<210> 4934
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 4934
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Thr Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Gly Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Glu Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Val Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Ser Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 4935
<211> 2211
<212> DNA
<213> Adeno-associated virus

<400> 4935
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcatcggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gccagactgg cgactcagag      540

tcagtccccg atccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgcacctg ggccttgccc acctacaata accacctcta caagcaaatc      780

tccagtactt caacgggggc cagcaacgac aaccactact tcggctacgg caccccctgg      840

gggtattttg atttcaacag attccactgc cacttttcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaaactctt caacatccaa      960

gtcgaggagg tcacgacgaa tgatggcgtc acaaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag cttccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcaatacgg ctacctgacg     1140

ctcaacaatg gcagccaagc cgtgggacgt tcatcctttt actgcctgga atatttccct     1200

tctcagatgc tgagaacggg caacaacttt accttcagct acacctttga ggaagtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

caatacctgt attacctgaa cagaacacaa aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgtgggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaat     1500

tttacctgga ctggtgcttc aaaatataac ctcaatgggc gtgaatccat catcaaccct     1560

ggcaccgctg tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaagagag cgccggagct tcaagcactg cattggacaa tgtcatgatt     1680

acagacgaag aggaaattaa agccactaac cctgtggcca ccgaaagatt tgggaccgtg     1740

gcagtcaatt tccagagcag cagcacagac cctgcgaccg gagatgtgca tgctatggga     1800

gcattacctg gcatggtgtg gcaagataga gacgtgtacc tgcagggtcc catttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccaat actccacagg acaagtgagt     2040

gtggaaattg aatgggagct gcagaaagaa aacagcaagc gctggaatcc cgaagtgcag     2100

tacacatcca attatgcaaa atctgccaac gttgatttta ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt taccttaccc gtcccctgta a              2211


<210> 4936
<211> 737
<212> PRT
<213> Adeno-associated virus

<400> 4936
Arg Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu 
1               5                   10                  15      


Ser Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys 
            20                  25                  30          


Pro Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu 
        35                  40                  45              


Pro Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu 
    50                  55                  60                  


Pro Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr 
65                  70                  75                  80  


Asp Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His 
                85                  90                  95      


Ala Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly 
            100                 105                 110         


Gly Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu 
        115                 120                 125             


Pro Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys 
    130                 135                 140                 


Arg Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile 
145                 150                 155                 160 


Gly Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Thr Ser Thr Gly Ala Ser Asn Asp Asn 
            260                 265                 270         


His Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Glu Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn 
        435                 440                 445             


Arg Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe 
    450                 455                 460                 


Ser Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp 
                485                 490                 495     


Asn Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu 
            500                 505                 510         


Asn Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Val Ala Ser His 
        515                 520                 525             


Lys Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe 
    530                 535                 540                 


Gly Lys Glu Ser Ala Gly Ala Ser Ser Thr Ala Leu Asp Asn Val Met 
545                 550                 555                 560 


Ile Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Arg Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro 
            580                 585                 590         


Ala Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly 
705                 710                 715                 720 


Leu Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro 
                725                 730                 735     


Leu 
    


<210> 4937
<211> 737
<212> PRT
<213> Adeno-associated virus

<400> 4937
Arg Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu 
1               5                   10                  15      


Ser Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys 
            20                  25                  30          


Pro Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu 
        35                  40                  45              


Pro Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu 
    50                  55                  60                  


Pro Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr 
65                  70                  75                  80  


Asp Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His 
                85                  90                  95      


Ala Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly 
            100                 105                 110         


Gly Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu 
        115                 120                 125             


Pro Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys 
    130                 135                 140                 


Arg Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile 
145                 150                 155                 160 


Gly Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Thr Ser Thr Gly Ala Ser Asn Asp Asn 
            260                 265                 270         


His Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn 
        435                 440                 445             


Arg Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe 
    450                 455                 460                 


Ser Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp 
                485                 490                 495     


Asn Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu 
            500                 505                 510         


Asn Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Val Ala Ser His 
        515                 520                 525             


Lys Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe 
    530                 535                 540                 


Gly Lys Glu Ser Ala Gly Ala Ser Ser Thr Ala Leu Asp Asn Val Met 
545                 550                 555                 560 


Ile Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Arg Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro 
            580                 585                 590         


Ala Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly 
705                 710                 715                 720 


Leu Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro 
                725                 730                 735     


Leu 
    


<210> 4938
<211> 737
<212> PRT
<213> Adeno-associated virus

<400> 4938
Arg Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu 
1               5                   10                  15      


Ser Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys 
            20                  25                  30          


Pro Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu 
        35                  40                  45              


Pro Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu 
    50                  55                  60                  


Pro Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr 
65                  70                  75                  80  


Asp Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His 
                85                  90                  95      


Ala Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly 
            100                 105                 110         


Gly Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu 
        115                 120                 125             


Pro Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys 
    130                 135                 140                 


Arg Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile 
145                 150                 155                 160 


Gly Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Thr Ser Thr Gly Ala Ser Asn Asp Asn 
            260                 265                 270         


His Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn 
        435                 440                 445             


Arg Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe 
    450                 455                 460                 


Ser Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp 
                485                 490                 495     


Asn Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu 
            500                 505                 510         


Asn Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Val Ala Ser His 
        515                 520                 525             


Lys Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe 
    530                 535                 540                 


Gly Lys Glu Ser Ala Gly Ala Asn Ser Thr Ala Leu Asp Asn Val Met 
545                 550                 555                 560 


Ile Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Arg Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro 
            580                 585                 590         


Ala Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly 
705                 710                 715                 720 


Leu Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro 
                725                 730                 735     


Leu 
    


<210> 4939
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4939
atggctgccg atggttatct tccagattgg ctcaaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcgggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agtacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaacagga      480

aaagcgggcc agcagcctgc gagaaagaga ttgaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaag ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggctctgccc acctacaaca accatctgta caagcagatc      780

tccagccaat caggagccag caacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg gcccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaggaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc ccggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgcttc gtaccggaaa caactttacc ttcagctaca cctttgagga tgttcctttc     1260

cacagcagct acgctcacag ccagagtttg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgca gtccaggctt     1380

cagttttctc aggccggagc aagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acagctgcgg acaacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg ccagccacaa ggacgatgaa gaaaagtttt ttcctcaaag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcagaac caccaatccc gtggccacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca gctactgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagac gtgcacctgc aggggcctat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt tggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcaaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtatt ccacagggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaaccccga gatccagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4940
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4940
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Lys Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Gly Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu Tyr Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Ser Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Pro Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val His Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4941
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4941
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcagagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaaaaga ttaaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggatct      600

actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acatacaaca accacctcta caagcaaatc      780

tccagccaat caggagccag caacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg gcccaaaaga ctcaacttca agctctttaa tattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tgggctcggc gcatcaagga     1080

tgcctcccgc cgtttccagc ggacgtcttc atggtcccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgctgc gtactggaaa caactttcag ttcagctaca cttttgaaga cgtgcctttc     1260

cacagcagct acgctcacag ccagagtctg gatcggctga tgaatcctct gatcgaccag     1320

tacctgtatt atctgaacaa gacacaaaca aatagtggaa ctcttcagca gtctcggcta     1380

ctgtttagcc aagctggacc aaccaacatg tctcttcaag ctaaaaactg gctgcctgga     1440

ccttgctaca gacagcagcg tctgtcaaaa caggcaaacg acaacaacaa cagcaacttt     1500

ccctggactg cagctacaaa gtatcatcta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagtcgcaa ggatgacgaa gaaaagtttt tccccatgca tggaaccctg     1620

atatttggta aacaaggaac aaatgccaac gacgcggatt tggaaaatgt catgattaca     1680

gatgaagaag aaatcagggc caccaatccc gtggctacgg agcagtacgg gactgtgtca     1740

aataatttgc aaaactcaaa cactggtcca actactggaa ctgtcaatca ccaaggagcg     1800

ttacctggta tggtgtggca ggatcgagac gtgtacctgc agggacccat ttgggccaag     1860

attcctcaca ccgatggaca ctttcatcct tctccactga tgggaggttt tggactcaaa     1920

cacccgcctc ctcagatcat gatcaaaaac actcccgttc cagccaatcc tcccacaaac     1980

ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4942
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4942
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys Thr 
        435                 440                 445             


Gln Thr Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Asn Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser Arg Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Glu Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Ala Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Thr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4943
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4943
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgggg aacctgtcaa gacggctcca      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcggct acgctcacag ccagagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcac aacaaacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacaatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtacgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4944
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4944
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Gly Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Gly Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Thr Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asn Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4945
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4945
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgggg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa tcggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta cagacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

agcaacggga gtcaggcagt aggacgctct tcattttact gcccggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcac aacaaacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacaatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacctaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atttgtaa                  2208


<210> 4946
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4946
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Gly Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Arg His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Arg Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Ser Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Pro Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Thr Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asn Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Pro Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4947
<211> 2205
<212> DNA
<213> Adeno-associated virus

<400> 4947
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaaaaga ctgaatttcg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcagacag ccaccagcag cccccacaag tttgggatct      600

actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accaccttta caagcaaatc      780

tccagccaat caggagcctc aaacgacaac cactactttg gctacagcac cccctggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgtttccagc ggacgtcttc atggtcccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgctgc gtactggaaa caactttcag ttcagctaca cttttgaaga cgtgcctttc     1260

cacagcagct acgctcacag ccagagtttg gatcggctga tgaatcctct gatcgaccag     1320

tacctgtatt atctaaacag aacacaaaca gctagtggaa ctcagcagtc tcggctactg     1380

tttagccaag ctggacccac aagcatgtct cttcaagcta aaaactggct gcctggaccg     1440

tgttatcgcc agcagcgttt gtcaaagcag gcaaacgaca acaacaacag caactttccc     1500

tggactggag ctaccaagta ctacctcaat ggcagagact ctttggtgaa cccgggcccg     1560

gccatggcca gccacaagga cgatgaagaa aagtttttcc ccatgcatgg aaccctaata     1620

tttggtaaag aaggaacaaa tgctaccaac gcggaattgg aaaatgtcat gattacagat     1680

gaagaggaaa tcaggaccac caatcccgtg gctacagagc agtacggata tgtgtcaaat     1740

aatttgcaaa actcaaatac tgctgcaagt actgaaactg tgaatcacca aggagcatta     1800

cctggtatgg tgtggcagga tcgagacgtg tacctgcagg gacccatttg ggccaagatt     1860

cctcacaccg atggacactt tcatccttct ccactgatgg gaggttttgg actcaaacac     1920

ccgcctcctc agattatgat caaaaacact cccgttccag ccaatcctcc cacaaacttc     1980

agttctgcca agtttgcttc cttcatcaca cagtattcca cgggacaggt cagcgtggag     2040

atcgagtggg agctgcagaa ggagaacagc aaacgctgga atcccgaaat tcagtacact     2100

tccaactaca acaaatctgt taatgtggac tttactgtgg acactaatgg tgtgtattca     2160

gagcctcgcc ccattggcac cagatacctg actcgtaatc tgtaa                     2205


<210> 4948
<211> 734
<212> PRT
<213> Adeno-associated virus

<400> 4948
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Arg Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Thr Ala Ser Gly Thr Gln Gln Ser Arg Leu Leu Phe Ser Gln Ala 
    450                 455                 460                 


Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly Pro 
465                 470                 475                 480 


Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn Asn 
                485                 490                 495     


Ser Asn Phe Pro Trp Thr Gly Ala Thr Lys Tyr Tyr Leu Asn Gly Arg 
            500                 505                 510         


Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp Asp 
        515                 520                 525             


Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys Glu 
    530                 535                 540                 


Gly Thr Asn Ala Thr Asn Ala Glu Leu Glu Asn Val Met Ile Thr Asp 
545                 550                 555                 560 


Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly 
                565                 570                 575     


Tyr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Ala Ala Ser Thr Glu 
            580                 585                 590         


Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp Arg 
        595                 600                 605             


Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp 
    610                 615                 620                 


Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His 
625                 630                 635                 640 


Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn Pro 
                645                 650                 655     


Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr 
            660                 665                 670         


Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu 
        675                 680                 685             


Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Asn 
    690                 695                 700                 


Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr Ser 
705                 710                 715                 720 


Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 


<210> 4949
<211> 3160
<212> DNA
<213> Adeno-associated virus

<400> 4949
acccttcact aaagggacta gtcctgcagg tttaaacgaa ttcgcccttg ctgcgtcaac       60

tggaccaatg agaactttcc cttcaacgac tgtgtcgaca agatggtgat ttggtgggag      120

gaggggaaga tgaccgccaa ggtcgtggag tcggccaaag ccattctcgg aggaagcaag      180

gtgcgcgtgg accagaaatg caagtcctcg gcccagatag atccgactcc cgtgatcgtc      240

acctccaaca ccaacatgtg cgccgtgatt gacgggaact caacgacctt cgaacaccag      300

cagccgttgc aagaccggat gttcaaattt gaactcaccc gccgtctgga tcatgacttt      360

gggaaggtca ccaagcggga agtcaaagac tttttccggt gggcaaagga tcacgtggtt      420

gaggtggagc atgaattcta cgtcaaaaag ggtggagcca agaaaagacc cgcccctagt      480

gacgcagata taagtgagcc caaacgggtg cgcgagtcag ttgcgcagcc atcgacgtca      540

gacgcggaag cttcgatcaa ctacgcggac aggtaccaaa acaaatgttc tcgtcacgtg      600

ggcatgaatc tgatgctgtt tccctgcaga caatgcgaga gaatgaatca aaattcaaat      660

atctgcttca ctcacggaca gaaagactgt ttagagtgct ttcccgtgtc agaatctcaa      720

cctgtttctg tcgtcaaaaa ggcgtatcag aaactgtgct acattcatca tatcatggga      780

aaggtgccag acgcttgcac tgcctgcgat ctggtcaatg tggatttgga tgactgcatc      840

tctgaacaat aaatgattta aatcaggtat ggctgccgat ggttatcttc cagattggct      900

cgaggacact ctctctgaag gaataagaca gtggtggaag ctcaaacctg gcccaccacc      960

accaaagccc gcagagcggc ataaggacga cagcaggggt cttgtgcttc ctgggtacaa     1020

gtacctcgga cccttcaacg gactcgacaa gggagagccg gtcaacgagg cagacgccgc     1080

ggccctcgag cacgacaagg cctacgaccg gcagctcgac agcggagaca acccgtacct     1140

caagtacaac cacgccgacg cggagtttca ggagcgtctt aaagaagata cgtcttttgg     1200

gggcaacctc ggacgagcag tcttccaggc gaaaaagagg gttcttgaac ctctgggcct     1260

ggttgaggaa cctgttaaga cggctccggg aaaaaagagg ccggtagagc actctcctgc     1320

ggagccagac tcctcctcgg gaaccggaaa agcgggccag cagcctgcaa gaaaaagact     1380

gaatttcggt cagactggag acgcagactc cgtacctgac ccccagcctc tcagacagcc     1440

accagcagcc cccacaagtt tgggatctac tacaatggct acaggcagtg gcgcaccaat     1500

ggcagacaat aacgagggtg ccgatggagt gggtaattcc tcaggaaatt ggcattgcga     1560

ttcccaatgg ctgggcgaca gagtcatcac caccagcacc cgaacctggg ccctgcccac     1620

ctacaacaac cacctttaca agcaaatctc cagccaatca ggagcctcaa acgacaacca     1680

ctactttggc tacagcaccc cctgggggta ttttgacttc aacagattcc actgccactt     1740

ttcaccacgt gactggcaaa gactcatcaa caacaactgg ggattccgac ccaagagact     1800

caacttcaag ctctttaaca ttcaagtcaa agaggtcacg cagaatgacg gtacgacgac     1860

gattgccaat aaccttacca gcacggttca ggtgtttact gactcggagt accagctccc     1920

gtacgtcctc ggctcggcgc atcaaggatg cctcccgccg tttccagcgg acgtcttcat     1980

ggtcccacag tatggatacc tcaccctgaa caacgggagt caggcggtag gacgctcttc     2040

cttttactgc ctggagtact ttccttctca gatgctgcgt actggaaaca actttcagtt     2100

cagctacact tttgaagacg tgcctttcca cagcagctac gctcacagcc agagtttgga     2160

tcggctgatg aatcctctga tcgaccagta cctgtattat ctaaacagaa cacaaacagc     2220

tagtggaact cagcagtctc ggctactgtt tagccaagct ggacccacaa gcatgtctct     2280

tcaagctaaa aactggctgc ctggaccgtg ttatcgccag cagcgtttgt caaagcaggc     2340

aaacgacaac aacaacagca actttccctg gactggagct accaagtact acctcaatgg     2400

cagagactct ttggtgaacc cgggcccggc catggccagc cacaaggacg atgaagaaaa     2460

gtttttcccc atgcatggaa ccctaatatt tggtaaagaa ggaacaaatg ctaccaacgc     2520

ggaattggaa aatgtcatga ttacagatga agaggaaatc aggaccacca atcccgtggc     2580

tacagagcag tacggatatg tgtcaaataa tttgcaaaac tcaaatactg ctgcaagtac     2640

tgaaactgtg aatcaccaag gagcattacc tggtatggtg tggcaggatc gagacgtgta     2700

cctgcaggga cccatttggg ccaagattcc tcacaccgat ggacactttc atccttctcc     2760

actgatggga ggttttggac tcaaacaccc gcctcctcag attatgatca aaaacactcc     2820

cgttccagcc aatcctccca caaacttcag ttctgccaag tttgcttcct tcatcacaca     2880

gtattccacg ggacaggtca gcgtggagat cgagtgggag ctgcagaagg agaacagcaa     2940

acgctggaat cccgaaattc agtacacttc caactacaac aaatctgtta atgtggactt     3000

tactgtggac actaatggtg tgtattcaga gcctcgcccc attggcacca gatacctgac     3060

tcgtaatctg taattgcttg ttaatcaata aaccgtttaa ttcgtttcag ttgaactttg     3120

gtctctgcga agggcgaatt cgcggccgct aaatcaatcg                           3160


<210> 4950
<211> 734
<212> PRT
<213> Adeno-associated virus

<400> 4950
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys Arg Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Gly Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Thr Ala Ser Gly Thr Gln Gln Ser Arg Leu Leu Phe Ser Gln Ala 
    450                 455                 460                 


Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly Pro 
465                 470                 475                 480 


Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn Asn 
                485                 490                 495     


Ser Asn Phe Pro Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Gly 
            500                 505                 510         


Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp Asp 
        515                 520                 525             


Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys Glu 
    530                 535                 540                 


Gly Thr Asn Ala Thr Asn Ala Glu Leu Glu Asn Val Met Ile Thr Asp 
545                 550                 555                 560 


Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly 
                565                 570                 575     


Tyr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Ala Ala Ser Thr Glu 
            580                 585                 590         


Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp Arg 
        595                 600                 605             


Asp Val Tyr Leu Arg Gly Pro Ile Trp Ala Lys Ile Pro His Ala Asp 
    610                 615                 620                 


Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His 
625                 630                 635                 640 


Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn Pro 
                645                 650                 655     


Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr 
            660                 665                 670         


Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu 
        675                 680                 685             


Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Asn 
    690                 695                 700                 


Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr Ser 
705                 710                 715                 720 


Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 


<210> 4951
<211> 3157
<212> DNA
<213> Adeno-associated virus

<400> 4951
ctcactaagg gactagtcct gcaggtttaa acgaattcgc ccttgctgcg tcaactggac       60

caatgagaac tttcccttca acgactgtgt cgacaagatg gtgatttggt gggaggaggg      120

gaagatgacc gccaaggtcg tggagtcggc caaagccact ctcggaggaa gcaaggtgcg      180

cgtggaccag aaacgcaagt cctcggccca gatagatccg actcccgtga tcgtcacctc      240

caacaccaac atgtgcgccg tgattgacgg gaactcaacg accttcgaac accagcagcc      300

gttgcaagac cgaatgttca aatttgaact cacccgccgt ctggatcatg acttcgggaa      360

ggtcaccaag caggaagtca aagacttttt ccggtgggca aaggatcacg tggttgaggt      420

ggagcatgaa ttctacgtca aaaagggtgg agccaagaaa agacccgccc ctagtgacgc      480

agatataagt gagcccaaac gggtgcgcga gtcagttgcg cagccatcga cgtcagacgc      540

ggaagcttcg atcaactacg cggacaggta ccaaaacaaa tgttctcgtc acgtgggcat      600

gaatctgatg ctgtttccct gcagacaatg cgagagaatg aatcaaaatt caaatatctg      660

cttcactcac ggacagaaag actgtttaga gtgctttccc gtgtcagaat ctcaacctgt      720

ttctgtcgtc aaaaaggcgt atcagaaact gtgctacatt catcatatca tgggaaaggt      780

gccagacgct tgcactgcct gcgatctggt caatgtggat ttggatgact gcatctctga      840

acaataaatg atttaaatca ggtatggctg ccgatggtta tcttccagat tggctcgagg      900

acactctctc tgaaggaata agacagtggt ggaagctcaa acctggccca ccaccaccaa      960

agcccgcaga gcggcataag gacgacagca ggggtcttgt gcttcctggg tacaagtacc     1020

tcggaccctt caacggactc gacaagggag agccggtcaa cgaggcagac gccgcggctc     1080

tcgagcacga caaggcctac gaccggcagc tcgacagcgg agacaacccg tacctcaagt     1140

acaaccacgc cgacgcggag tttcaggagc gtcttaaaga agatacgtct tttgggggca     1200

acctcggacg agcagtcttc caggcgaaaa agagggttct tgaacctctg ggcctggttg     1260

aggaacctgt taagacggct ccgggaaaaa agaggccggt agagcactct cctgcggagc     1320

cagactcctc ctcgggaacc ggaaaagcgg gccagcagcc tgcaagaaaa agactgaatt     1380

tcggtcagac tggagacgca gactccgtac ctgaccccca gcctctcgga cagccaccag     1440

cagcccccac aagtttggga tctactacaa tggctacagg cagtggcgca ccaatggcag     1500

acaataacga gggtgccgat ggagtgggta attcctcagg aaattggcat tgcgattccc     1560

aatggctggg cgacagagtc atcaccacca gcacccgaac ctgggccctg cccacctaca     1620

acaaccacct ttacaagcaa atctccagcc aatcaggagc ctcaaacgac aaccactact     1680

ttggctacag caccccctgg gggtattttg acttcaacag attccactgc cgcttttcac     1740

cacgtgactg gcaaagactc atcaacaaca actggggatt ccgacccaag agactcaact     1800

tcaagctctt taacattcaa gtcaaagagg tcacgcagaa tgacggtacg acgacgattg     1860

ccaataacct taccagcacg gttcaggtgt ttactgactc ggagtaccag ctcccgtacg     1920

tcctcggctc ggcgcatcaa ggatgcctcc cgccgtttcc agcggacgtc ttcatggtcc     1980

cacagtatgg atacctcacc ctgaacaacg ggagtcaggc ggtaggacgc tcttcctttt     2040

actgcctgga gtactttcct tctcagatgc tgcgtactgg aaacaacttt cagttcagct     2100

acacttttga agacgtgcct ttccacagca gctacgctca cagccagggt ttggatcggc     2160

tgatgaatcc tctgatcgac cagtacctgt attatctaaa cagaacacaa acagctagtg     2220

gaactcagca gtctcggcta ctgtttagcc aagctggacc cacaagcatg tctcttcaag     2280

ctaaaaactg gctgcctgga ccgtgttatc gccagcagcg tttgtcaaag caggcaaacg     2340

acaacaacaa cagcaacttt ccctggactg gagctaccaa gtaccacctc aatggcggag     2400

actctttggt gaacccgggc ccggccatgg ccagccacaa ggacgatgaa gaaaagtttt     2460

tccccatgca tggaacccta atatttggta aagaaggaac aaatgctacc aacgcggaat     2520

tggaaaatgt catgattaca gatgaagagg aaatcaggac caccaatccc gtggctacag     2580

agcagtacgg atatgtgtca aataatttgc aaaactcaaa tactgctgca agtactgaaa     2640

ctgtgaatca ccaaggagca ttacctggta tggtgtggca ggatcgagac gtgtacctgc     2700

ggggacccat ttgggccaag attcctcacg ccgatggaca ctttcatcct tctccactga     2760

tgggaggttt tggactcaaa cacccgcctc ctcagattat gatcaaaaac actcccgttc     2820

cagccaatcc tcccacaaac ttcagttctg ccaagtttgc ttccttcatc acacagtatt     2880

ccacgggaca ggtcagcgtg gagatcgagt gggagctgca gaaggagaac agcaaacgct     2940

ggaatcccga aattcagtac acttccaact acaacaaatc tgttaatgtg gactttactg     3000

tggacactaa tggtgtgtat tcagagcctc gccccattgg caccagatac ctgactcgta     3060

atctgtaatt gcttgttaat caataaaccg tttaattcgt ttcagttgaa ctttggtctc     3120

tgcgaagggc gaattcgcgg ccgctaaatt caattcg                              3157


<210> 4952
<211> 734
<212> PRT
<213> Adeno-associated virus

<400> 4952
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Cys Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Thr Ala Ser Gly Thr Gln Gln Ser Arg Leu Leu Phe Ser Gln Ala 
    450                 455                 460                 


Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly Pro 
465                 470                 475                 480 


Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn Asn 
                485                 490                 495     


Ser Asn Phe Pro Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg 
            500                 505                 510         


Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp Asp 
        515                 520                 525             


Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys Glu 
    530                 535                 540                 


Gly Thr Asn Ala Thr Asn Ala Glu Leu Glu Asn Val Met Ile Thr Asp 
545                 550                 555                 560 


Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly 
                565                 570                 575     


Tyr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Ala Ala Ser Thr Glu 
            580                 585                 590         


Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp Arg 
        595                 600                 605             


Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp 
    610                 615                 620                 


Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His 
625                 630                 635                 640 


Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn Pro 
                645                 650                 655     


Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr 
            660                 665                 670         


Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu 
        675                 680                 685             


Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Asn 
    690                 695                 700                 


Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr Ser 
705                 710                 715                 720 


Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 


<210> 4953
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4953
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctggatac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaagcgggca accagcctgc aagaaaaaga ttgaatttcg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcat ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcgtc      720

accaccagca cccgcacctg ggccctgccc acctacaaca accacctcta caagcagatt      780

tccagccaat caggagccag caacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcgccac gcgactggca gagactcatc      900

aacaacaact ggggattccg gcccaaaaga ctcaacttca agctgtttaa cattcaagtc      960

aaggaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgacttgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgcttc gcaccggaaa caactttacc ttcagctaca cttttgaaga cgttcctttc     1260

cacagcagct acgctcacag tcaaagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccactacgca gtccaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acagctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg ccagccacaa ggacgatgaa gaaaagtttt ttcctcaaag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac caccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca gctacctcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagac gtgtacctgc aggggcccat ctgggcaaaa     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt tggacttaaa     1920

caccctcctc cacagattct cattaagaat accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagcgcgg caaagtttgc ttccttcatc acacagtatt ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggggtgtat     2160

tcagagcctc gccctattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4954
<211> 3159
<212> DNA
<213> Adeno-associated virus

<400> 4954
gattgattta gcggccgcga attcgccctt gctgcgtcaa ctggaccaat gagaactttc       60

ccttcaacga ttgcgtcgac aagatggtga tctggtggga ggagggaaag atgaccgcca      120

aggtcgtgga gtcggccaaa gccattctcg gaggaagcaa ggtgcgtgtg gaccaaaagt      180

gcaagtcttc ggcccagatc gacccgactc ccgtgatcgt cacctccaac accaacatgt      240

gcgccgtgat tgatggaaac tcaacgacct tcgagcacca gcagccgttg caagaccgga      300

tgttcaaatt tgaacttacc cgccgtctgg atcatgactt tggaaaggtc accaagcagg      360

aagtgaaaga ctttttccgg tgggcaaagg atcacgtggt tgaggtggag catgagttct      420

acgtcaaaaa gggtggagcc aaaaaaagac ccgcccccag tgacgcagat ataagtgagc      480

ccaaacgggc gcgcgagtca gttgcgcagc catcgacgtc agacgcggaa gcttcgatca      540

actacgcgga caggtaccaa aacaaatgtt ctcgtcacgt gggcatgaat ctgatgctgt      600

ttccctgcag acaatgcgag agaatgaatc agaattcaaa tatctgcttc actcacggac      660

agaaagactg tccatagtgc tttcccgtgt cagaatctca acccgtttct gtcgtcaaaa      720

aggcgtatca gaaactgtgc tacattcatc acatcatggg aaaggtgcca gacgcttgca      780

ctgcttgcga cctggtcaat gtggatttgg atgactgcat ctctgaacaa taaatgattt      840

aaatcaggta tggctgccga tggttatctt ccagattggc tcgaggacac tctctctgaa      900

ggaataagac agtggtggaa gctcaaacct ggcccaccac caccaaagcc cgcagagcgg      960

cataaggacg acagcagggg tcttgtgctt cctggataca agtacctcgg acccttcaac     1020

ggactcgaca agggagagcc ggtcaacgag gcagacgccg cggccctcga gcacgacaag     1080

gcctacgacc ggcagctcga cagcggagac aacccgtacc tcaagtacaa ccacgccgac     1140

gcggagtttc aggagcgcct taaagaagat acgtcttttg ggggcaacct cggacgagca     1200

gtcttccagg cgaaaaagag ggttcttgaa cctctgggcc tggttgagga acctgttaag     1260

acggctccgg gaaaaaagag gccggtagag cactctcctg tggagccaga ctcctcctcg     1320

ggaaccggaa aagcgggcaa ccagcctgca agaaaaagat tgaatttcgg tcagactgga     1380

gacgcagact ccgtacctga cccccagcct ctcggacagc caccagcatc cccctctggt     1440

ctgggaacta atacgatggc tacaggcagt ggcgcaccaa tggcagacaa taacgagggc     1500

gccgacggag tgggtaattc ctcgggaaat tggcattgcg attccacatg gatgggcgac     1560

agagtcgtca ccaccagcac ccgcacctgg gccctgccca cctacaacaa ccacctctac     1620

aagcagattt ccagccaatc aggagccagc aacgacaacc actactttgg ctacagcacc     1680

ccttgggggt attttgactt caacagattc cactgccact tttcgccacg cgactggcag     1740

agactcatca acaacaactg gggattccgg cccaaaagac tcaacttcaa gctgtttaac     1800

attcaagtca aggaggtcac gcagaatgac ggtacgacga cgattgccaa taaccttacc     1860

agcacggttc aggtgtttac tgacttggag taccagctcc cgtacgtcct cggctcggcg     1920

catcaaggat gcctcccgcc gttcccagca gacgtcttca tggtgccaca gtatggatac     1980

ctcaccctga acaacgggag tcaggcggta ggacgctctt ccttttactg cctggagtac     2040

tttccttctc agatgcttcg caccggaaac aactttacct tcagctacac ttttgaagac     2100

gttcctttcc acagcagcta cgctcacagt caaagtctgg accgtctcat gaatcctctc     2160

atcgaccagt acctgtatta cttgagcaga acaaacactc caagcggaac cactacgcag     2220

tccaggcttc agttttctca ggccggagcg agtgacattc gggaccagtc taggaactgg     2280

cttcctggac cctgttaccg ccagcagcga gtatcaaaga cagctgcgga taacaacaac     2340

agtgaatact cgtggactgg agctaccaag taccacctca atggcagaga ctctctggtg     2400

aatccgggcc cggccatggc cagccacaag gacgatgaag aaaagttttt tcctcaaagc     2460

ggggttctca tctttgggaa gcaaggctca gagaaaacaa atgtggacat tgaaaaggtc     2520

atgattacag acgaagagga aatcaggacc accaatcccg tggctacgga gcagtatggt     2580

tctgtatcta ccaacctcca gagcggcaac acacaagcag ctacctcaga tgtcaacaca     2640

caaggcgttc ttccaggcat ggtctggcag gacagagacg tgtacctgca ggggcccatc     2700

tgggcaaaaa ttccacacac ggacggacat tttcacccct ctcccctcat gggcggattt     2760

ggacttaaac accctcctcc acagattctc attaagaata ccccggtacc tgcgaatcct     2820

tcgaccacct tcagcgcggc aaagtttgct tccttcatca cacagtattc cacggggcag     2880

gtcagcgtgg agatcgagtg ggagctgcag aaggagaaca gcaaacgctg gaatcccgaa     2940

attcagtaca cttccaacta caacaaatct gttaatgtgg actttactgt ggacactaat     3000

ggggtgtatt cagagcctcg ccctattggc accagatacc tgactcgtaa tctgtaattg     3060

cttgttaatc aataaaccgt ttaattcgtt tcagttgaac tttggtctct gcgaagggcg     3120

aattcgttta aacctgcagg actagtccct ttagtgagg                            3159


<210> 4955
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4955
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Asn Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ser Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Val 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Leu Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ser Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4956
<211> 2205
<212> DNA
<213> Adeno-associated virus

<400> 4956
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaaagcccg cagagcggca taaggacgac      120

agcaggggtc ttgtgcttcc tggatacaag tacctcggac ccttcaacgg actcgacaag      180

ggagagccgg tcaacgaggc agacgccgcg gccctcgagc acgacaaggc ctacgaccgg      240

cagctcgaca gcggagacaa cccgtacctc aagtacaacc acgccgacgc ggagtttcag      300

gagcgcctta aagaagatac gtcttttggg ggcaacctcg gacgagcagt cttccaggcg      360

aaaaagaggg ttcttgaacc tctgggcctg gttgaggaac ctgttaagac ggctccggga      420

aaaaagaggc ccgtagagca ctctcctgtg gagccagact cctcctcggg aaccggaaaa      480

gcgggcaacc agcctgcaag aaaaagattg aatttcggtc agactggaga cgcagactcc      540

gtacctgacc cccagcctct cggacagcca ccagcagccc cctctggtct gggaactaat      600

acgatggcta caggcagtgg cgcaccaatg gcagacaata acgagggcgc cgacggagtg      660

ggtaattcct cgggagattg gcattgcgat tccacatgga tgggcgacag agtcatcacc      720

accagcaccc gcacctgggc cctgcccacc tacaacaacc acctctacaa gcagatttcc      780

agccaatcag gagccagcaa tgacaaccac tactttggct acagcacccc ttgggggtat      840

tttgacttca acagattcca ctgccacttt tcgccacgcg actggcagag actcatcaac      900

aacaactggg gattccggcc caaaagactc aacctcaagc tgtttaacat tcaagtcaag      960

gaggtcacgc agaatgacgg tacgacgacg attgccaata accttaccag cacggttcag     1020

gtgtttactg acttggagta ccagctcccg tacgtcctcg gctcggcgca tcaaggatgc     1080

ctcccgccgt tcccagcaga cgtcttcatg gtgccacagt atggatacct caccctgaac     1140

aacgggagtc aggcggtagg acgctcttcc ttttactgcc tggagtactt tccttctcag     1200

atgcttcgta ccggaaacaa ctttaccttc agctacactt ttgaagacgt tcctttccac     1260

agcagctacg ctcacagtca aagtctggac cgtctcatga atcctctcat cgaccagtac     1320

ctgtattact tgagcagaac aaacactcca agcggaacca ctacgcagtc caggcttcag     1380

ttttctcagg ccggagcgag tgacattcgg gaccagtcta ggaactggct tcctggaccc     1440

tgttaccgcc agcagcgagt atcaaagaca gctgcggata acaacaacgg tgaatactcg     1500

tggactggag ctaccaagta ccacctcaat ggcagagact ctctggtgaa tccgggcccg     1560

gccatggcca gccacaagga cgatgaagaa aagttttttc ctcaaagcgg ggttctcatc     1620

tttgggaagc aaggctcaga gaaaacaaat gtggacattg aaaaggtcat gattacagac     1680

gaagaggaaa tcaggaccac caatcccgtg gctacggagc agtatggttc tgtatctacc     1740

aacctccaga gcggcaacac acgagcagct acctcagatg tcaacacaca aggcgttctt     1800

ccaggcatgg tctggcagga cagagacgtg tacctgcagg ggcccatctg ggcaaaaatt     1860

ccacacacgg acggacattt tcacccctct cccctcatgg gcggatttgg acttaaacac     1920

cctcctccac agattctcat taagaatacc ccggtacctg cgaatccttc gaccaccttc     1980

agcgcggcaa agtttgcttc cttcatcaca cagtattcca cggggcaggt cagcgtggag     2040

atcgagtggg agctgcagaa ggagaacagc aaacgctgga atcccgaaat tcagtacact     2100

tccaactaca acaaatctgt taatgtggac tttactgtgg acactaatgg ggtgtattca     2160

gagcctcgcc ctattggcac cagatacctg actcgtaatc tgtaa                     2205


<210> 4957
<211> 3156
<212> DNA
<213> Adeno-associated virus

<400> 4957
cgattgaatt tagcggccgc gaattcgccc ttgctgcgtc aacggaccaa tgagaacttt       60

cccttcaacg attgcgtcga caagatggtg atctggtggg aggagggaaa gatgaccgcc      120

aaggtcgtgg agtcggccaa agccattctc ggaggaagca aggtgcgtgt ggaccaaaag      180

tgcaagtctt cggcccagat cgacccgact cccgtgatcg tcacctccaa caccaacatg      240

tgcgccgtga ttgatggaaa ctcaacgacc ttcgagcacc agcagccgtt gcaagaccgg      300

atgttcaaat ttgaacttac ccgccgtctg gatcatgact ttggaaaggt caccaagcag      360

gaagtgaaag actttttccg gtgggcaaag gatcacgtgg ttgaggtgga gcatgagttc      420

tacgtcaaaa agggtggagc caaaaaaaga cccgccccca gtgacgcaga tataagtgag      480

cccaaacggg cgcgcgagtc agttgcgcag ccatcgacgt cagacgcgga agcttcgatc      540

aactacgcgg acaggtacca aaacaaatgt tctcgtcacg tgggcatgaa tctgatgctg      600

tttccctgca gacaatgcga gcgaatgaat cagaattcaa atatctgctt cactcacgga      660

cagaaagact gtttagagtg ctttcccgtg tcagaatctc aacccgtttc tgtcgtcaaa      720

aaggcgtatc agaaactgtg ctacattcat cacatcatgg gaaaggtgcc agacgcttgc      780

actgcttgcg acctggtcaa tgtggatttg gatgactgca tctctgaaca ataaatgatt      840

taaatcaggt atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga      900

aggaataaga cagtggtgga agctcaaacc tggcccacca ccaaagcccg cagagcggca      960

taaggacgac agcaggggtc ttgtgcttcc tggatacaag tacctcggac ccttcaacgg     1020

actcgacaag ggagagccgg tcaacgaggc agacgccgcg gccctcgagc acgacaaggc     1080

ctacgaccgg cagctcgaca gcggagacaa cccgtacctc aagtacaacc acgccgacgc     1140

ggagtttcag gagcgcctta aagaagatac gtcttttggg ggcaacctcg gacgagcagt     1200

cttccaggcg aaaaagaggg ttcttgaacc tctgggcctg gttgaggaac ctgttaagac     1260

ggctccggga aaaaagaggc ccgtagagca ctctcctgtg gagccagact cctcctcggg     1320

aaccggaaaa gcgggcaacc agcctgcaag aaaaagattg aatttcggtc agactggaga     1380

cgcagactcc gtacctgacc cccagcctct cggacagcca ccagcagccc cctctggtct     1440

gggaactaat acgatggcta caggcagtgg cgcaccaatg gcagacaata acgagggcgc     1500

cgacggagtg ggtaattcct cgggagattg gcattgcgat tccacatgga tgggcgacag     1560

agtcatcacc accagcaccc gcacctgggc cctgcccacc tacaacaacc acctctacaa     1620

gcagatttcc agccaatcag gagccagcaa tgacaaccac tactttggct acagcacccc     1680

ttgggggtat tttgacttca acagattcca ctgccacttt tcgccacgcg actggcagag     1740

actcatcaac aacaactggg gattccggcc caaaagactc aacctcaagc tgtttaacat     1800

tcaagtcaag gaggtcacgc agaatgacgg tacgacgacg attgccaata accttaccag     1860

cacggttcag gtgtttactg acttggagta ccagctcccg tacgtcctcg gctcggcgca     1920

tcaaggatgc ctcccgccgt tcccagcaga cgtcttcatg gtgccacagt atggatacct     1980

caccctgaac aacgggagtc aggcggtagg acgctcttcc ttttactgcc tggagtactt     2040

tccttctcag atgcttcgta ccggaaacaa ctttaccttc agctacactt ttgaagacgt     2100

tcctttccac agcagctacg ctcacagtca aagtctggac cgtctcatga atcctctcat     2160

cgaccagtac ctgtattact tgagcagaac aaacactcca agcggaacca ctacgcagtc     2220

caggcttcag ttttctcagg ccggagcgag tgacattcgg gaccagtcta ggaactggct     2280

tcctggaccc tgttaccgcc agcagcgagt atcaaagaca gctgcggata acaacaacgg     2340

tgaatactcg tggactggag ctaccaagta ccacctcaat ggcagagact ctctggtgaa     2400

tccgggcccg gccatggcca gccacaagga cgatgaagaa aagttttttc ctcaaagcgg     2460

ggttctcatc tttgggaagc aaggctcaga gaaaacaaat gtggacattg aaaaggtcat     2520

gattacagac gaagaggaaa tcaggaccac caatcccgtg gctacggagc agtatggttc     2580

tgtatctacc aacctccaga gcggcaacac acgagcagct acctcagatg tcaacacaca     2640

aggcgttctt ccaggcatgg tctggcagga cagagacgtg tacctgcagg ggcccatctg     2700

ggcaaaaatt ccacacacgg acggacattt tcacccctct cccctcatgg gcggatttgg     2760

acttaaacac cctcctccac agattctcat taagaatacc ccggtacctg cgaatccttc     2820

gaccaccttc agcgcggcaa agtttgcttc cttcatcaca cagtattcca cggggcaggt     2880

cagcgtggag atcgagtggg agctgcagaa ggagaacagc aaacgctgga atcccgaaat     2940

tcagtacact tccaactaca acaaatctgt taatgtggac tttactgtgg acactaatgg     3000

ggtgtattca gagcctcgcc ctattggcac cagatacctg actcgtaatc tgtaattgct     3060

tgttaatcaa taaaccgttt aattcgtttc agttgaactt tggtctctgc gaagggcgaa     3120

ttcgtttaaa cctgcaggac tagtcccttt agtgag                               3156


<210> 4958
<211> 734
<212> PRT
<213> Adeno-associated virus

<400> 4958
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Lys 
            20                  25                  30          


Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro Val 
    50                  55                  60                  


Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp Arg 
65                  70                  75                  80  


Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Leu 
        115                 120                 125             


Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg Pro 
    130                 135                 140                 


Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly Lys 
145                 150                 155                 160 


Ala Gly Asn Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr Gly 
                165                 170                 175     


Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro Ala 
            180                 185                 190         


Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly Ala 
        195                 200                 205             


Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser Ser 
    210                 215                 220                 


Gly Asp Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile Thr 
225                 230                 235                 240 


Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr 
                245                 250                 255     


Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr Phe 
            260                 265                 270         


Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys 
        275                 280                 285             


His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly 
    290                 295                 300                 


Phe Arg Pro Lys Arg Leu Asn Leu Lys Leu Phe Asn Ile Gln Val Lys 
305                 310                 315                 320 


Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu Thr 
                325                 330                 335     


Ser Thr Val Gln Val Phe Thr Asp Leu Glu Tyr Gln Leu Pro Tyr Val 
            340                 345                 350         


Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val 
        355                 360                 365             


Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln 
    370                 375                 380                 


Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln 
385                 390                 395                 400 


Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu Asp 
                405                 410                 415     


Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu 
            420                 425                 430         


Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr Asn 
        435                 440                 445             


Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln Ala 
    450                 455                 460                 


Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly Pro 
465                 470                 475                 480 


Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn Asn 
                485                 490                 495     


Gly Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg 
            500                 505                 510         


Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp Asp 
        515                 520                 525             


Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys Gln 
    530                 535                 540                 


Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr Asp 
545                 550                 555                 560 


Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly 
                565                 570                 575     


Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Arg Ala Ala Thr Ser 
            580                 585                 590         


Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp Arg 
        595                 600                 605             


Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp 
    610                 615                 620                 


Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His 
625                 630                 635                 640 


Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn Pro 
                645                 650                 655     


Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr 
            660                 665                 670         


Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu 
        675                 680                 685             


Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Asn 
    690                 695                 700                 


Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr Ser 
705                 710                 715                 720 


Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 


<210> 4959
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4959
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtacg accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcaaaaaaga gggttcttga acctctgggc ctggttgagg agcctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaagcgggca accagcctgc aagaaagaga ttgaatttcg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgatgg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggctctgccc acctacaaca accatctgta caagcagatt      780

tccagccaat caggagccag caacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg gcccaagaga ctcaacttca agctctttaa cattcaagtc      960

agagaggtca cgcagaatga tggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta cttcccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cctttgagga tgttcctttc     1260

cacagcagct acgctcacag ccagagtttg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgca gtccaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggatcagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg acaacaacaa cagtgaatac     1500

tcgtggattg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggcaatgg ccagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggaa aacaaggatc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcagaac caccaatccc gtggccacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca tctactgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagac gtgtacctgc aggggcctat ctgggcaaag     1860

attccgcaca cggacggaca ttttcacccc tctcccctca tgggcggatt cggacttaaa     1920

caccctcctc cacagattct catcaaaaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtatt ccacggggcg ggtcagcgtg     2040

gagatcgagt gggagctaca gaaggagaac agcaaacgct ggaatcccga gatccagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4960
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4960
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asp His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Asn Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Asp Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Arg Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Ile Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ser Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Arg Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4961
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 4961
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagacag gccagcagcc cgcgaaaaag agactcaact ttgggcagac tggcgactca      540

gagtcagtgc ccgaccctca accaatcgga gaaccccccg caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcagg aaattggcat tgcgattccg catggctggg cgacagagtc      720

atcaccacca gcacccgacc ctgggccctc cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacatcggg aggaagcacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcaacttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taaccttacc     1020

agcacgattc aggtctttac ggactcggaa taccagctcc cgtacgtcct cggctctgcg     1080

caccagggct gcccgcctcc gttcccggcg gacgtcttca tgattcctca gtacgggtac     1140

ctgactctga acaacggcag tcaggccgtg ggccgttcct ccttctactg cctggagtac     1200

tttccttctc aaatgcggag aacgggcaac aactttgagt tcagctacca gtttgaggac     1260

gtgccttttc acagcagcta cgcgcatagc caaagcctgg accggctgat gaaccccctc     1320

atcgaccagt acctgtacta cctgtctcgg actcagtcca cgggaggtac cgcaggaact     1380

cagcagttgc tattttctca ggccgggcct aataacatgt cggctcaggc caaaaactgg     1440

ctacccgggc cctgctaccg gcagcaacgc gtctccacga cactgtcgca aaataacaac     1500

agcaactttg cttggaccgg tgccaccaag tatcatctga atggcagaga ctctctggta     1560

aatcccggtg tcgctatggc aacgcacaag gacgacgaag agcgattttt tccatccagc     1620

ggagtcttga tgtttgggaa acagggagct ggaaaagaca acgtggacta tagcagcgtt     1680

atgctaacca gtgaggaaga aatcaaaacc accaacccag tggccacaga acagtacggc     1740

gtggtggccg ataacctgca acagcaaaac gccgctccta ttgtaggggc cgtcaacagt     1800

caaggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatc     1860

tgggccaaga ttcctcacac ggacggcaac tttcatcctt cgccgctgat gggaggcttt     1920

ggactgaaac acccgcctcc tcagatcctg attaagaata cacctgttcc cgcggatcct     1980

ccaactacct tcagtcaagc caagctggcg tcgttcatca cgcagtacag caccggacag     2040

gtcagcgtgg aaattgaatg ggagctgcag aaagagaaca gcaagcgctg gaacccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgtgg actttgctgt caatactgag     2160

ggtacttatt cagagcctcg ccccattggc acccgttacc tcacccgtaa cctgtaa        2217


<210> 4962
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4962
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Ala Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Pro Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Pro Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Arg Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4963
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4963
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Val Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys Thr 
        435                 440                 445             


Gln Thr Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Asn Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Glu Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Thr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4964
<211> 3158
<212> DNA
<213> Adeno-associated virus

<400> 4964
gattgaattt agcggccgcg aattcgccct tgctgcgtca actggaccaa tgagaacttt       60

cctttcaatg attgcgtcga caagatggtg atctggtggg aggagggaaa gatgaccgcc      120

aaggtcgtgg agtcggccaa agccattctc ggaggaagca aggtgcgcgc ggaccagaaa      180

tgcaagtcct cggcccagat agacccgact cccgtgattg tcacctccaa caccaacatg      240

tgcgccgtga ttgacgggaa ctcaacgacc ttcgaacacc agcagccgtt gcaagaccgg      300

atgttcaaat ttgaactcac ccgccgtctg gatcatgact ttgggaaggt caccaagcag      360

gaagtcaaag actttttccg gtgggcaaag gatcacgtgg ttgaggtgga gcatgaattc      420

tacgtcaaaa agggtggagc taagaaaaga cccgccccca gtgacgcaga tataagtgag      480

cccaaacggg cgcgcgagtc agttgcgcag ccatcgacgt cagacgcgga agcttcgatc      540

aactacgcgg gcaggtacca aaacaaatgt tctcgtcacg tgggcatgaa tctgatgctg      600

tttccctgca gacaatgcga gagaatgaat cagaattcaa atatctgctt cactcacgga      660

cagaaagact gtttagagtg ctttcccgtg tcagaatctc aacccgtttc tgtcgtcaaa      720

aaggcgtatc agaaactttg ctacattcat catatcatgg gaaaggtgcc agacgcttgc      780

actgcctgcg atctggtcaa tgtggatttg gatgactgca tctctgaaca ataaatgatt      840

taaatcaggt atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga      900

aggaataaga cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg      960

gcataaggac gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa     1020

cggactcgac aagggggagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa     1080

ggcctacgac cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga     1140

cgcggagttt caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc     1200

agtcttccag gcaaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa     1260

aacggctccg ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc     1320

gggaaccgga aaagcgggcc agcagcctgc aagaaaaaga ttgaatttcg gtcagactgg     1380

agacgcagac tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg     1440

tctgggatct actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg     1500

tgccgatgga gtgggtaatt cctcgggaaa ttggcattgc gattcccaat ggctgggcga     1560

cagagtcatc accaccagca cccgcacctg ggccctgccc acctacaaca accacctcta     1620

caagcaaatc tccagccaat caggagcctc aaacgacaac cactactttg gctacagcac     1680

cccctggggg tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca     1740

aagactcatc aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa     1800

cattcaagtc aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac     1860

cagcacggtt caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc     1920

gcatcaagga tgcctcccgc cgtttccagc ggacgtcttc atggtcccac agtatggata     1980

cctcaccctg aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta     2040

ctttccttct cagatgctgc gtaccggaaa caactttcaa ttcagctaca cttttgaaga     2100

cgtgcctttc cacagcagct acgctcacag ccagagtctg gatcggctga tgaatcctct     2160

ggtcgaccag tacctgtatt atctgaacaa gacacaaaca aatagtggaa ctcttcagca     2220

gtctcggcta ctgtttagcc aagctggacc caccaacatg tctcttcaag ctaaaaactg     2280

gctgcctgga ccttgctaca gacagcagcg tctgtcaaag caggcaaacg acaacaacaa     2340

cagcaacttt ccctggactg cagctacaaa gtatcatcta aatggccggg actcgttggt     2400

taatccagga ccagctatgg ccagtcacaa ggatgacgaa gaaaagtttt tccccatgca     2460

tggaaccctt atatttggta aacaaggaac aaatgccaac gacgcggatt tggaaaatgt     2520

catgattaca gatgaagaag aaatcaggac caccaatccc gtggctacgg agcagtacgg     2580

aactgtatca aataatttgc aaaactcaaa cactggtcca actactggaa ctgtcaatca     2640

ccaaggagcg ttacctggta tggtgtggca ggatcgagac gtgtacctgc agggacccat     2700

ttgggccaag attcctcaca ccgatggaca ctttcatcct tctccactga tgggaggttt     2760

tggactcaaa cacccacctc ctcaaatcat gatcaaaaac actcccgttc cagccaatcc     2820

tcccacaaac ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacggggca     2880

ggtcagcgtg gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga     2940

aattcagtac acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa     3000

tggtgtgtat tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaatt     3060

gcttgttaat caataaaccg tttaattcgt ttcagttgaa ctttggtctc tgcgaagggc     3120

gaattcgttt aaacctgcag gactagtccc tttagtga                             3158


<210> 4965
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4965
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Pro Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys Thr 
        435                 440                 445             


Gln Thr Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Asn Met Ser Leu Gln Ala Lys Asn Arg Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Glu Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Thr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Val Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4966
<211> 3159
<212> DNA
<213> Adeno-associated virus

<400> 4966
gattgaattt agcggccgcg aattcgccct tgctgcgtca actggaccaa tgagaacttt       60

cctttcaatg attgcgtcga caagatggtg atctggtggg aggagggaaa gatgaccgcc      120

aaggtcgtgg agtcggccaa agccattctc ggaggaagca aggtgcgcgt ggaccagaaa      180

tgcaagtcct cggcccagat agacccgact cccgtgattg tcacctccaa caccgacatg      240

tgcgccgtga ttgacgggaa ctcaacgacc ttcgaacacc agcagccgtt gcaagaccgg      300

atgttcaaat ttgaactcac ccgccgtctg gatcatgact ttgggaaggt caccaagcag      360

gaagtcaaag actttttccg gtgggcaaag gatcacgtgg ttgaggtgga gcatgaattc      420

tacgtcaaaa agggtggagc taagaaaaga cccgccccca gtgacgcaga tataagtgag      480

cccaaacggg cgcgcgagtc agttgcgcag ccatcgacgt cagacgcgga agcttcgatc      540

aactacgcgg acaggtacca aaacaaatgt tctcgtcacg tgggcatgaa tctgatgctg      600

tttccctgca gacaatgcga gagaatgaat cagaattcaa atatctgctt cactcacgga      660

cagaaagact gtttagagtg ctttcccgtg tcagaatctc aacccgtttc tgtcgtcaaa      720

aaggcgtatc agaaactttg ctacattcat catatcatgg gaaaggtgcc agacgcttgc      780

actgcctgcg atctggtcaa tgtggatttg gatgactgca tctctgaaca ataaatgatt      840

taaatcaggt atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga      900

aggaataaga cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg      960

gcataaggac gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa     1020

cggactcgac aagggggagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa     1080

ggcctacgac cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga     1140

cgcggagttt caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc     1200

agtcttccag gcaaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa     1260

aacggctccg ggaaaaaaga ggccggtaga gcaccctcct gtggagccag actcctcctc     1320

gggaaccgga aaagcgggcc agcagcctgc aagaaaaaga ttgaatttcg gtcagactgg     1380

agacgcagac tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg     1440

tctgggatct actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg     1500

tgccgatgga gtgggtaatt cctcgggaaa ttggcattgc gattcccaat ggctgggcga     1560

cagagtcatc accaccagca cccgcacctg ggccctgccc acctacaaca accacctcta     1620

caagcaaatc tccagccaat caggagcctc aaacgacaac cactactttg gctacagcac     1680

cccctggggg tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca     1740

aagactcatc aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa     1800

cattcaagtc aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac     1860

cagcacggtt caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc     1920

gcatcaagga tgcctcccgc cgtttccagc ggacgtcttc atggtcccac agtatggata     1980

cctcaccctg aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta     2040

ctttccttct cagatgctgc gtaccggaaa caactttcag ttcagctaca cttttgaaga     2100

cgtgcctttc cacagcagct acgctcacag ccagagtctg gatcggctga tgaatcctct     2160

gatcgaccag tacctgtatt atctgaacaa gacacaaaca aatagtggaa ctcttcagca     2220

gtctcggcta ctgtttagcc aagctggacc caccaacatg tctcttcaag ctaaaaaccg     2280

gctgcctgga ccttgctaca gacagcagcg tctgtcaaag caggcaaacg acaacaacaa     2340

cagcaacttt ccctggaccg cagctacaaa gtatcatcta aatggccggg actcgttggt     2400

taatccagga ccagctatgg ccagtcacaa ggatgacgaa gaaaagtttt tccccatgca     2460

tggaaccctt atatttggta aacaaggaac aaatgccaac gacgcggatt tggaaaatgt     2520

catgattaca gatgaagaag aaatcaggac caccaatccc gtggctacgg agcagtacgg     2580

aactgtatca aataatttgc aaaactcaaa cactggtcca actactggaa ctgtcaatca     2640

ccaaggagcg ttacctggta tggtgtggca ggatcgagac gtgtacctgc agggacccat     2700

ttgggccaag attcctcaca ccgatggaca ctttcatcct tctccactgg tgggaggttt     2760

tggactcaaa cacccacctc ctcaaatcat gatcaaaaac actcccgttc cagccaatcc     2820

tcccacaaac ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacggggca     2880

ggtcagcgtg gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga     2940

aattcagtac acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa     3000

tggtgtgtat tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaatt     3060

gcttgttaat caataaaccg tttaattcgt ttcagttgaa ctttggtctc tgcgaagggc     3120

gaattcgttt aaacctgcag gactagtccc tttagtgag                            3159


<210> 4967
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4967
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtaccttg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac cccaagtaca accacgccga cgcggagttc      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaagaga ttgaatttcg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgcacctg ggctctgccc acctacaaca accacctcta caagcagatt      780

tccagccaat caggagcctc aaacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcgccac gtgactggca aagactcatc      900

aacaacaatt ggggattccg gcccaaaaga ctcaacttca agctctttaa cattcaagtc      960

aaggaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cctttgagga cgttcctttc     1260

cacagcagct acgcccacag ccagagtttg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc aagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctt aatggaagag actctctggt gaatccgggc     1560

ccggccatgg ccagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggaa aacaagactc gggaaaaact aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac caccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca gctacctcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtgtggca ggacagagac gtgtacctgc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt cggacttaaa     1920

caccctcccc cgcagattct catcaagaac accccggtac ctgcgaatcc ttcgactacc     1980

ttcagtgcgg caaagtttgc ttccttcatt acacagtact ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga gattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccaggtac ctgactcgta atctgtaa                  2208


<210> 4968
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4968
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Pro Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Asp Ser Gly Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ser Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4969
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4969
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtaccttg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acggcggaga caacccgtac ctcaagtaca accacgccga cgcggagttc      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctctt gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaggaga ttgaatttcg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgcacctg ggctctgccc acctacaaca accacctcta caggcagatt      780

tccagccaat caggagcctc aaacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcgccac gtgactggca aagactcatc      900

aacaacaatt ggggatcccg gcccaaaaga ctcaacttca agctctttaa cattcaagtc      960

aaggaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cctttgagga cgttcctttc     1260

cacagcagct acgcccacag ccagagtttg gaccgtctca tgaatcctct cgtcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagcggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc aagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctt aatggaagag actctctggt gaatccgggc     1560

ccggccatgg ccagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggaa aacaagactc gggaaaaact aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac caccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagcggcaa cacacaagca gctacctcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtgtggca ggacagagac gtgtacctgc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggcggatt cggacttaaa     1920

caccctcccc cgcagattct catcaagaac accccggtac ctgcgaatcc ttcgactacc     1980

ttcagtgcgg caaagtttgc ttccttcatt acacagtact ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaaacgct ggaatcccga gattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4970
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4970
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Gly Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Leu Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Arg Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Arg Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Ser Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Val Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Asp Ser Gly Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ser Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4971
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4971
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Ala Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Glu Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Cys Ala His Ser Gln Ser 
            420                 425                 430         


Ser Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Arg Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4972
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 4972
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcttggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaatgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctaaaaag agactgaact ttggtcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atatccaatg ggacatcggg aggaagcacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt caacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg ccaaaaagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taaccttacc     1020

agcacgattc aggtatttac ggactcggaa taccagctgc cgtacgtcct cggctccgcg     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcccca gtacggctac     1140

cttacactga acaatggaag tcaagccgta ggccgttcct ccttctactg cctggaatat     1200

tttccatctc aaatgctgcg aactggaaac aattttgaat tcagctacac cttcgaggac     1260

gtgcctttcc acagcggcta cgcacacagc cagagcttgg accgactgat gaatcctctc     1320

atcgaccagt acctgtacta cttatccaga actcagtcca caggaggaac tcaaggtacc     1380

cagcaattgt tattttctca agctgggcct gcaaacatgt cggctcaggc taagaactgg     1440

ctacctggac cttgctaccg gcagcagcga gtctctacga cactgtcgca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa tatcacctga acggaagaga ctctttggta     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccgtcgagt     1620

ggagtcctga tgtttggaaa acagggtgct ggaagagaca atgtggacta cagcagcgtt     1680

atgctaacca gcgaagaaga aattaaaacc actaaccctg tagccacaga acaatacggt     1740

gtggtggctg acaacttgca gcaaaccaat acagggccta ttgtgggaaa tgtcaacagc     1800

caaggagcct tacctggcat ggtctggcag aaccgagacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccaccctt caccgctaat gggaggattt     1920

ggactgaagc acccacctcc tcagatcctg atcaagaaca cgccggtacc tgcggatcct     1980

ccaacgacgt tcagccaggc gaaattggct tccttcatta cgcagtacag caccggacag     2040

gtcagcgtgg aaatcgagtg ggagctgcag aaggagaaca gcaaacgctg gaacccagag     2100

attcagtaca cttcaaacta ctacaaatct acaaatgtgg actttgctgt caatacagag     2160

ggaacttatt ctgagcctcg ccccattggt actcgttacc tcacccgtaa tctgtaa        2217


<210> 4973
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4973
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Leu 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Gly Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4974
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4974
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Pro Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys Thr 
        435                 440                 445             


Gln Ser Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Asp Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Tyr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4975
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4975
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Gly Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys Thr 
        435                 440                 445             


Gln Ser Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Asp Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Tyr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4976
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4976
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg gacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tttgggatct      600

actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caagcaaatc      780

tcaagccaat caggagcctc aaacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcgggtcggc gcatcaagga     1080

tgcctcccgc cgtttccagc ggacgtcttc atggtcccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgcttc gtactggaaa caactttcag ttcagctaca cctttgaaga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gatcggctga tgaatcctct gatcgaccag     1320

tacctgtatt atctgaacaa aacacaatca aatagtggaa ctcttcagca gtctcggcta     1380

ctgtttagtc aagctggacc caccagcatg tctcttcaag ctaaaaactg gctacctgga     1440

ccttgctaca gacagcagcg tctgtcaaag caggcaaacg acaacaacaa cagcaacttt     1500

ccctggactg cggctacaaa gtatcaccta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagtcacaa agacgatgaa gaaaagtttt tccccatgca tggaaccctg     1620

atatttggta aacaaggaac aaatgctaac gacgcggatt tggacaatgt catgattaca     1680

gatgaagaag aaatccgcac caccaatccc gtggctacgg agcagtacgg atatgtgtca     1740

aataatttgc aaaactcaaa tactggtcca actactggaa ctgtcaatca ccaaggagcg     1800

ttacctggca tggtgtggca ggatcgagac gtgtacctgc agggacccat ttgggccaag     1860

attcctcaca ccgatggaca ctttcatcct tctccactga tgggaggttt tgggctcaaa     1920

cacccgcctc ctcagatcat gatcaaaaac actcccgttc cagccaatcc tcccacaaac     1980

ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaagagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4977
<211> 2211
<212> DNA
<213> Adeno-associated virus

<400> 4977
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcatcggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg atccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgcacctg ggccttgccc acctacaata accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc cacttttcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaaactctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acaaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag cttccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcaatacgg ctacctgacg     1140

ctcaacaatg gcagccaagc cgtgggacgt tcatcctttt actgcctgga atatttccct     1200

tctcagatgc tgagaacggg caacaacttt accttcagct acacctttga ggaagtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

caatacctgt attacctgaa cagaactcaa aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgtgggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaat     1500

tttacctgga ctggtgcttc aaaatataac ctcaatgggc gtgaatccat catcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaagagag cgccggagct tcaaacactg cattggacaa tgtcatgatt     1680

acagacgaag aggaaattaa agccactaac cctgtggcca ccgaaagatt tgggaccgtg     1740

gcagtcaatt tccagagcag cagcacagac cctgcgaccg gagatgtgca tgctatggga     1800

gcattacctg gcatggtgtg gcaagataga gacgtgtacc tgcagggtcc catttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccaat actccacagg acaagtgagt     2040

gtggaaattg aatgggagct gcagaaagaa aacagcaagc gctggaatcc cgaagtgcag     2100

tacacatcca attatgcaaa atctgccaac gttgatttta ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt taccttaccc gtcccctgta a              2211


<210> 4978
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4978
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaacaaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tttgggatct      600

actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caagcaaatc      780

tcaagccaat caggagcctc aaacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcgggtcggc gcatcaagga     1080

tgcctcccgc cgtttccagc ggacgtcttc atggtcccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgcttc gtactggaaa caactttcag ttcagctaca cctttgaaga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gatcggctga tgaatcctct gatcgaccag     1320

tacctgtatt atctgaacaa aacacaatca aatagtggaa ctcttcagca gtctcggcta     1380

ctgtttagtc aagctggacc caccagcatg tctcttcaag ctaaaaactg gctacctgga     1440

ccttgctaca gacagcagcg tctgtcaaag caggcaaacg acaacaacaa cagcaacttt     1500

ccctggactg cggctacaaa gtaccaccta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagtcacaa agacgatgaa gaaaagtttt tccccatgca tggaaccctg     1620

atatttggta aacaaggaac aaatgctaac gacgcggatt tggacaatgt catgattaca     1680

gatgaagaag aaatccgcac caccaatccc gtggctacgg agcagtacgg atatgtgtca     1740

aataatttgc aaaactcaaa tactggtcca actactggaa ctgtcaatca ccaaggagcg     1800

ttacctggca tggtgtggca ggatcgagac gtgtacctgc agggacccat ttgggccaag     1860

attcctcaca ccgatggaca ctttcatcct tctccactga tgggaggttt tgggctcaaa     1920

cacccgcctc ctcagatcat gatcaaaaac actcccgttc cagccaatcc tcccacaaac     1980

ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaagagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4979
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 4979
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctaaaaag agactgaact ttggtcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccacctg caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atatccaatg ggacatcggg agggagcacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt caacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg ccaaaaagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taaccttacc     1020

agcacgattc aggtatttac ggactcggaa taccagctgc cgtacgtcct cggctccgcg     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcccca gtacggctac     1140

cttacactga acaatggaag tcaagccgta ggccgttcct ccttctactg cctggaatat     1200

tttccatctc aaatgctgcg aactggaaac aattttgaat tcagctacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcacacagc cagagcttgg accgactgat gaatcctctc     1320

atcgaccagt acctgtacta cttatccaga actcagtcca caggaggaac tcaaggtacc     1380

cagcaattgt tattttctca agctgggcct gcaaacatgt cggctcaggc taagaactgg     1440

ctacctggac cttgctaccg gcagcagcga gtctctacga cactgtcgca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa tatcacctga acggaagaga ctctttggta     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccgtcgagt     1620

ggagtcctga tgtttggaaa acagggtgct ggaagagaca atgtggacta cagcagcgtt     1680

atgctaacca gcgaagaaga aattaaaacc actaaccctg tagccacaga acaatacggt     1740

gtggtggctg acaacttgca gcaaaccaat acagggccta ttgtgggaaa tgtcaacagc     1800

caaggagcct tacctggcat ggtctggcag aaccgagacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac tgccaccctt caccgctaat gggaggattt     1920

ggactgaagc acccacctcc tcagatcctg atcaagaaca cgccggtacc tgcggatcct     1980

ccaacaacgt tcagccaggc gaaattggct tccttcatta cgcagtacag caccggacag     2040

gtcagcgtgg aaatcgagtg ggagctgcag aaggagaaca gcaaacgctg gaacccagag     2100

attcagtaca cttcaaacta ctacaaatct acaaatgtgg actttgctgt caatacagag     2160

ggaacttatt ctgagcctcg ccccattggt actcgttacc tcacccgtaa tctgtaa        2217


<210> 4980
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4980
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Thr Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys Thr 
        435                 440                 445             


Gln Ser Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Asp Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Tyr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4981
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 4981
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcatcaggac      120

aacagcaggg gtcttgtgct tcctgggtac aagtacctcg gaccctccaa cggactcgac      180

aaaggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaagcgggcc atcagcctgc gagaaagaga ttgaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag cccccacaag tttgggatct      600

actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caagcaaatc      780

tccagccaat caggagcctc gaacgacaac cactactttg gctgcagcac cccctggggg      840

tattttgact tcaacagatt ccactgtcac ttctccccac gtgattggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtacccgctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgtttccagc ggacgtcttc atggtcccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cctttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtttg gaccggctga tgaatcctct gatcgaccag     1320

tatctatatt atctgaacag gacacaatca aatagtggaa ctcttcagca gtctaggcta     1380

ctgtttagcc aagctggacc caccagcatg tctcttcaag ctaaaaactg gctgcctgga     1440

ccttgctaca gacagcagcg tctttcaaag caggcaaacg acaacaacaa cagcaacttt     1500

ccctggactg cggctacaaa gtatcatcta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagccacaa agacgatgaa gaaaagtttt tccccatgca tggaaccctg     1620

atatttggta aacaaggaac aaatgctaac gacgcggatt tggagcatgt tatgattaca     1680

gatgaagaag aaatcaggac caccaatcct gtggctacag agcagtacgg aaacgtgtca     1740

aataatttgc aaaactcaaa tactggtcca actacagaaa atgtcaatca ccagggagcg     1800

ttacctggta tggtgtggca ggatcgagac gtgtacctgc agggacccat ttgggccaag     1860

attcctcaca ccgacggaca ctttcaccct tctccactga tgggaggttt tggactcaaa     1920

cacccgcctc ctcaaatcat gatcaaaaac actcccgttc cagccaatcc tcccacaaac     1980

ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacgggcca ggtcagcgtg     2040

gagattgagt gggagctgca gaaggagaac agcaaacgct ggaaccccga gatccagtat     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggtgtgtat     2160

tcagagcctt gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 4982
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 4982
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Gln Asp Asn Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Ser Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly His Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Cys Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Pro Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Ser Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Glu His Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Asn Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Glu Asn Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Cys Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 4983
<211> 2196
<212> DNA
<213> Adeno-associated virus

<400> 4983
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg caacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacga ggcggacgcc gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caagagcgtc tgcaagaaga tacgtccttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga gggtactcga gcctctgggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaagc ggccagtaga accggactcc agctcgggca tcggcaagtc aggccagcag      480

cccgcgaaaa agagactgaa ttttgggcag actggcgact cagagtcagt gcctgacccc      540

caacctctct cagaaccacc cgcaggtccc tctggtctgg gatctggtac aatggctgct      600

ggcggtggcg ctccaatggc agacaataac gaaggcgccg acggagtggg taatgtctca      660

ggaaattggc attgcgattc cacatggctg ggcgaccgag tcatcaccac cagcactcgg      720

acctgggccc tccccaccta caacaaccac ctctacaagc aaatctccaa cgggacctcg      780

ggaggcagca gcaacgacaa cacctacttt ggctacagca ccccctgggg gtattttgac      840

tttaacagat tccactgcca cttttcacca cgtgactggc agcgactcat caacaacaac      900

tgggggttcc ggcccaagaa gctcaacttc aagctcttca acatccaggt caaggaggtc      960

acccagaatg aaggcaccaa gaccatcgcc aataacctca ccagcacggt gcaggtcttt     1020

acggactcgg agtaccagct cccgtacgtg ctcggctctg cccaccaggg ctgcctgcct     1080

ccgttcccgg cggacgtgtt catgattccg cagtacgggt acctgacgct gaacaacggg     1140

agccaggccg tggggcgatc ctccttctac tgcctggagt actttccctc gcagatgctg     1200

agaacgggca acaactttac cttcagctac accttcgagg acgtgccctt ccacagcagc     1260

tacgcgcaca gccagagcct ggaccggctg atgaacccgc tgattgacca gtacctgtac     1320

tacctgtctc ggactcagac caacgggacc aatgccacgc agactctgtt gtttgctcag     1380

gccgggcctc agaacatgtc ggctcaggcc aagaactggc tgcctggtcc ttgctatcgg     1440

cagcagcgcg tctctacgac agtgtcgcaa aacaacaaca gcaactttac ctggaccggg     1500

gcgaccaagt accacctgaa cggccgagac tccctggtga gccccggtgt cgccatggca     1560

acgcacaagg acgacgagga gcgcttcttc ccgagcagcg gggtcctgat gtttggcaag     1620

cagggcgctg gaaaggacaa tgtcgagtac accaacgtga tgctcaccag cgaggaggag     1680

atcaagacca ccaaccctgt ggccacggag cagtacggcg tggtggctga caatctgcag     1740

cagaccaact cagctcccat tgtgggggca gtcaacagcc agggggcctt acccggtatg     1800

gtctggcaga accgggacgt gtacctgcag ggtcccatct gggccaagat cccgcatacg     1860

gacggcaact ttcacccgtc tcctctcatg ggcggctttg gactgaaaca cccgcctccc     1920

cagatcctga tcaaaaacac gccggtacct gcggatcccc cggtgaactt tacggacgct     1980

aagctggcga gtttcatcac gcagtacagc accgggcagg tcagcgtgga gattgagtgg     2040

gagctgcaga aggagaacag caagcgctgg aatcccgaga ttcagtacac ttccaattat     2100

tataaatcag ctaatgtgga ctttgccgtc aatgcagatg gtgtatatag tgaaccccgc     2160

cccattggca ctcgttacct cacccgtaat ctgtaa                               2196


<210> 4984
<211> 731
<212> PRT
<213> Adeno-associated virus

<400> 4984
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Asp Ser Ser Ser Gly Ile Gly Lys Ser Gly Gln Gln 
145                 150                 155                 160 


Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu Ser 
                165                 170                 175     


Val Pro Asp Pro Gln Pro Leu Ser Glu Pro Pro Ala Gly Pro Ser Gly 
            180                 185                 190         


Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala Asp 
        195                 200                 205             


Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Val Ser Gly Asn Trp His 
    210                 215                 220                 


Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr Arg 
225                 230                 235                 240 


Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser 
                245                 250                 255     


Asn Gly Thr Ser Gly Gly Ser Ser Asn Asp Asn Thr Tyr Phe Gly Tyr 
            260                 265                 270         


Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe 
        275                 280                 285             


Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg 
    290                 295                 300                 


Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val 
305                 310                 315                 320 


Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr 
                325                 330                 335     


Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly 
            340                 345                 350         


Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met 
        355                 360                 365             


Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ala Val 
    370                 375                 380                 


Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu 
385                 390                 395                 400 


Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu Asp Val Pro 
                405                 410                 415     


Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn 
            420                 425                 430         


Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr Gln Thr Asn 
        435                 440                 445             


Gly Thr Asn Ala Thr Gln Thr Leu Leu Phe Ala Gln Ala Gly Pro Gln 
    450                 455                 460                 


Asn Met Ser Ala Gln Ala Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg 
465                 470                 475                 480 


Gln Gln Arg Val Ser Thr Thr Val Ser Gln Asn Asn Asn Ser Asn Phe 
                485                 490                 495     


Thr Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asp Ser Leu 
            500                 505                 510         


Val Ser Pro Gly Val Ala Met Ala Thr His Lys Asp Asp Glu Glu Arg 
        515                 520                 525             


Phe Phe Pro Ser Ser Gly Val Leu Met Phe Gly Lys Gln Gly Ala Gly 
    530                 535                 540                 


Lys Asp Asn Val Glu Tyr Thr Asn Val Met Leu Thr Ser Glu Glu Glu 
545                 550                 555                 560 


Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly Val Val Ala 
                565                 570                 575     


Asp Asn Leu Gln Gln Thr Asn Ser Ala Pro Ile Val Gly Ala Val Asn 
            580                 585                 590         


Ser Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr 
        595                 600                 605             


Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe 
    610                 615                 620                 


His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro 
625                 630                 635                 640 


Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Val Asn 
                645                 650                 655     


Phe Thr Asp Ala Lys Leu Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly 
            660                 665                 670         


Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys 
        675                 680                 685             


Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Ala 
    690                 695                 700                 


Asn Val Asp Phe Ala Val Asn Ala Asp Gly Val Tyr Ser Glu Pro Arg 
705                 710                 715                 720 


Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730     


<210> 4985
<211> 2196
<212> DNA
<213> Adeno-associated virus

<400> 4985
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg caacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacga ggcggacgcc gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caagagcgtc tgcaagaaga tacgtccttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga gggtactcga gcctctgggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaagc ggccagtaga accggactcc agctcgggca tcggcaagtc aggccggcag      480

cccgcgaaaa agagactgaa ttttgggcag actggcgact cagagtcagt gcctgacccc      540

caacctctct cagaaccacc cgcaggtccc tctggtctgg gatctggtac aatggctgca      600

ggcggtggcg ctccaatggc agacaataac gaaggcgccg acggagtggg taatgcctca      660

ggaaattggc attgcgattc cacatggctg ggcgaccgag tcatcaccac cagcactcgg      720

acctgggccc tccccaccta caacaaccac ctctacaagc aaatctccaa cgggacctcg      780

ggaggcagca gcaacgacaa cacctacttt ggctacagca ccccctgggg gtattttgac      840

tttaacagat tccactgcca cttttcacca cgtgactggc agcgactcat caacaacaac      900

tggggattcc ggcccaagag gctcaacttc aagctcttca acatccaggt caaggaggtc      960

acccagaatg aaggcaccaa gaccatcgcc aataacctca ccagcacggt gcaggtcttt     1020

acggactcga agtaccagct cccgtacgtg ctcggctctg cccaccaggg ctgcctgcct     1080

ccgttcccgg cggacgtgtt catgattccg cagtacgggt acctgacgct gaacaacggg     1140

agccaggccg tggggcgatc ctccttctac tgcctggagt actttccctc gcagatgctg     1200

agaacgggca acaactttac cttcagctac accttcgagg acgtgccctt ccacagcagc     1260

tacgcgcaca gccagagcct ggaccggctg atgaacccgc tgattgacca gtacctgtac     1320

tacctgtctc ggactcagac caacgggacc aatgccacgc agactctgtt gtttgctcag     1380

gccgggcctc agaacatgtc ggctcaggcc aagaactggc tgcctggtcc ttgctatcgg     1440

cagcagcgcg tctctacgac agtgtcgcaa aacaacaaca gcaactttac ctggaccggg     1500

gcgaccaagt accacctgaa cggccgagac tccctggtga accccggtgt cgccatggca     1560

acgcacaagg acgacgagga gcgcttcttc ccgagcagcg gggtcctgat gtttggcaag     1620

cagggcgctg gaaaggacaa tgtcgagtac accaacgtga tgctcaccag cgaggaggag     1680

atcaagacca ccaaccctgt ggccacggag cagtacggtg tggtggctga caatctgcag     1740

cagaccaact cggctcccat tgtgggggca gtcaacagcc agggggcctt acccggtatg     1800

gtctggcaga accgggacgt gtacctgcag ggtcccatct gggccaagat cccgcatacg     1860

gacggcaact ttcacccgtc tcctctcatg ggcggctttg gactgaaaca cccgcctccc     1920

cagatcctga tcaaaaacac gccggtacct gcggatcccc cggtgaactt tacggacgct     1980

aagctggcga gtttcatcac gcagtacagc accgggcagg tcagcgtgga gattgagtgg     2040

gagctgcaga aggagaacag caagcgctgg aatcccgaga ttcagtacac ttccaattat     2100

tataaatcag ctaatgtgga ctttgccgtc aatgcagatg gtgtatatag tgaaccccgc     2160

cccattggca ctcgttacct cacccgtaat ctgtaa                               2196


<210> 4986
<211> 731
<212> PRT
<213> Adeno-associated virus

<400> 4986
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Asp Ser Ser Ser Gly Ile Gly Lys Ser Gly Arg Gln 
145                 150                 155                 160 


Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu Ser 
                165                 170                 175     


Val Pro Asp Pro Gln Pro Leu Ser Glu Pro Pro Ala Gly Pro Ser Gly 
            180                 185                 190         


Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala Asp 
        195                 200                 205             


Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp His 
    210                 215                 220                 


Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr Arg 
225                 230                 235                 240 


Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser 
                245                 250                 255     


Asn Gly Thr Ser Gly Gly Ser Ser Asn Asp Asn Thr Tyr Phe Gly Tyr 
            260                 265                 270         


Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe 
        275                 280                 285             


Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg 
    290                 295                 300                 


Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val 
305                 310                 315                 320 


Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr 
                325                 330                 335     


Val Gln Val Phe Thr Asp Ser Lys Tyr Gln Leu Pro Tyr Val Leu Gly 
            340                 345                 350         


Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met 
        355                 360                 365             


Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ala Val 
    370                 375                 380                 


Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu 
385                 390                 395                 400 


Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu Asp Val Pro 
                405                 410                 415     


Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn 
            420                 425                 430         


Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr Gln Thr Asn 
        435                 440                 445             


Gly Thr Asn Ala Thr Gln Thr Leu Leu Phe Ala Gln Ala Gly Pro Gln 
    450                 455                 460                 


Asn Met Ser Ala Gln Ala Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg 
465                 470                 475                 480 


Gln Gln Arg Val Ser Thr Thr Val Ser Gln Asn Asn Asn Ser Asn Phe 
                485                 490                 495     


Thr Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asp Ser Leu 
            500                 505                 510         


Val Asn Pro Gly Val Ala Met Ala Thr His Lys Asp Asp Glu Glu Arg 
        515                 520                 525             


Phe Phe Pro Ser Ser Gly Val Leu Met Phe Gly Lys Gln Gly Ala Gly 
    530                 535                 540                 


Lys Asp Asn Val Glu Tyr Thr Asn Val Met Leu Thr Ser Glu Glu Glu 
545                 550                 555                 560 


Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly Val Val Ala 
                565                 570                 575     


Asp Asn Leu Gln Gln Thr Asn Ser Ala Pro Ile Val Gly Ala Val Asn 
            580                 585                 590         


Ser Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr 
        595                 600                 605             


Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe 
    610                 615                 620                 


His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro 
625                 630                 635                 640 


Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Val Asn 
                645                 650                 655     


Phe Thr Asp Ala Lys Leu Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly 
            660                 665                 670         


Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys 
        675                 680                 685             


Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Ala 
    690                 695                 700                 


Asn Val Asp Phe Ala Val Asn Ala Asp Gly Val Tyr Ser Glu Pro Arg 
705                 710                 715                 720 


Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730     


<210> 4987
<211> 2196
<212> DNA
<213> Adeno-associated virus

<400> 4987
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg caacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacga ggcggacgcc gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caagagcgtc tgcaagaaga tacgtccttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga gggtactcga gcctctgggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaagc ggccagtaga accggactcc agctcgggca tcggcaagtc aggccagcag      480

cccgcgaaaa agagactgaa ttttgggccg actggcgact cagagtcagt gcctgacccc      540

caacctctct cagaaccacc tgcaggtccc tctggtctgg gatctggtac aatggctgca      600

ggcggtggcg ctccaatggc agacaataac gaaggcgccg acggagtggg taatgtctca      660

ggaaattggc attgcgattc cacatggctg ggcgaccgag tcatcaccac cagcactcgg      720

acctgggccc tccccaccta caacaaccac ctctacaagc aaatctccaa cgggacctcg      780

ggaggcagca gcaacgacaa cacctacttt ggctacagca ccccctgggg gtattttgac      840

tttaacagat tccactgcca cttttcacca cgcgactggc agcgactcat caacaacaac      900

tggggattcc ggcccaagaa gctcaacttc aagctcttca acatccaggt caaggaggtc      960

acccagaatg aaggcaccaa gaccaccgcc aataacctca ccagcacggt gcaggtcttt     1020

acggactcgg agtaccagct cccgtacgtg ctcggctctg cccaccaggg ctgcctgcct     1080

ccgttcccgg cggacgtgtt catgattccg cagtacgggt acctgacgct gaacaacggg     1140

agccaggccg tggggcgatc ctccttctac tgcctggagt actttccctc gcagatgctg     1200

agaacgggca acaactttac cttcagctac accttcgagg acgtgccctt ccacagcagc     1260

tacgcgcaca gccagagcct ggaccggctg atgaacccgc tgattgacca gtacctgtac     1320

tacctgtctc ggactcagac caacgggacc aatgccacgc agactctgtt gtttgctcag     1380

gccgggcctc agaacatgtc ggctcaggcc aagaactggc tgcctggtcc ttgctatcgg     1440

cagcagcgcg tctctacggc agtgtcgcaa aacaacaaca gcaactttac ctggaccggg     1500

gcgaccaagt accacctgaa cggccgagac tccctggtga accccggtgt cgccatggca     1560

acgcacaagg acgacgagga gcgcttcttc ccgagcagcg gggtcctgat gtttggcaag     1620

cagggcgctg gaaaggacaa tgtcgagtac accaacgtga tgctcaccag cgaggaggag     1680

atcaagacca ccaaccctgt ggccacggag cagtacggtg tggtggctga caatctgcag     1740

cagaccaact cggctcccat tgtgggggca gtcaacagcc agggggcctt acccggtatg     1800

gtctggcaga accgggacgt gtacctgcag ggtcccatct gggccaagat cccgcatacg     1860

gacggcaact ttcacccgtc tcctctcatg ggcggctttg gactgaaaca cccgcctccc     1920

cagatcctga tcaaaaacac gccggtacct gcggatcccc cggtgaactt tacggacgct     1980

aagctggcga gtttcatcac gcagtacagc accgggcagg tcagcgtgga gattgagtgg     2040

gagctgcaga aggagaacag caagcgctgg aatcccgaga ttcagtacac ttccaattat     2100

tataaatcag ctaatgtgga ctttgccgtc aatgcagatg gtgtatatag cgaaccccgc     2160

cccattggca ctcgttacct cacccgtaat ctgtaa                               2196


<210> 4988
<211> 731
<212> PRT
<213> Adeno-associated virus

<400> 4988
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Asp Ser Ser Ser Gly Ile Gly Lys Ser Gly Gln Gln 
145                 150                 155                 160 


Pro Ala Lys Lys Arg Leu Asn Phe Gly Pro Thr Gly Asp Ser Glu Ser 
                165                 170                 175     


Val Pro Asp Pro Gln Pro Leu Ser Glu Pro Pro Ala Gly Pro Ser Gly 
            180                 185                 190         


Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala Asp 
        195                 200                 205             


Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Val Ser Gly Asn Trp His 
    210                 215                 220                 


Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr Arg 
225                 230                 235                 240 


Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser 
                245                 250                 255     


Asn Gly Thr Ser Gly Gly Ser Ser Asn Asp Asn Thr Tyr Phe Gly Tyr 
            260                 265                 270         


Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe 
        275                 280                 285             


Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg 
    290                 295                 300                 


Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val 
305                 310                 315                 320 


Thr Gln Asn Glu Gly Thr Lys Thr Thr Ala Asn Asn Leu Thr Ser Thr 
                325                 330                 335     


Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly 
            340                 345                 350         


Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met 
        355                 360                 365             


Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ala Val 
    370                 375                 380                 


Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu 
385                 390                 395                 400 


Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu Asp Val Pro 
                405                 410                 415     


Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn 
            420                 425                 430         


Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr Gln Thr Asn 
        435                 440                 445             


Gly Thr Asn Ala Thr Gln Thr Leu Leu Phe Ala Gln Ala Gly Pro Gln 
    450                 455                 460                 


Asn Met Ser Ala Gln Ala Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg 
465                 470                 475                 480 


Gln Gln Arg Val Ser Thr Ala Val Ser Gln Asn Asn Asn Ser Asn Phe 
                485                 490                 495     


Thr Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asp Ser Leu 
            500                 505                 510         


Val Asn Pro Gly Val Ala Met Ala Thr His Lys Asp Asp Glu Glu Arg 
        515                 520                 525             


Phe Phe Pro Ser Ser Gly Val Leu Met Phe Gly Lys Gln Gly Ala Gly 
    530                 535                 540                 


Lys Asp Asn Val Glu Tyr Thr Asn Val Met Leu Thr Ser Glu Glu Glu 
545                 550                 555                 560 


Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly Val Val Ala 
                565                 570                 575     


Asp Asn Leu Gln Gln Thr Asn Ser Ala Pro Ile Val Gly Ala Val Asn 
            580                 585                 590         


Ser Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr 
        595                 600                 605             


Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe 
    610                 615                 620                 


His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro 
625                 630                 635                 640 


Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Val Asn 
                645                 650                 655     


Phe Thr Asp Ala Lys Leu Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly 
            660                 665                 670         


Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys 
        675                 680                 685             


Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Ala 
    690                 695                 700                 


Asn Val Asp Phe Ala Val Asn Ala Asp Gly Val Tyr Ser Glu Pro Arg 
705                 710                 715                 720 


Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730     


<210> 4989
<211> 4404
<212> DNA
<213> Adeno-associated virus

<400> 4989
atggctgccg atggttatct tccagattgg ctcgagggca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aggtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

aagcagctcg agcaggggga caacccgtac ctcaagtaca accacgccga cgccgagttt      300

caggagcgtc ttcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gacccataga atcccccgac tcctccacgg gcatcggcaa gaacggccag      480

ccgcccgcta aaaagaagct caactttggg cagactggcg actcagagtc agtgcccgac      540

ccccaacctc tcggagaacc tcccgccgcg ccctcaggtc tgggatctgg tacaatggct      600

gcaggcggtg gcgcaccaat ggcagacaat aacgaaggcg ccgacggagt gggtaatgcc      660

tccggaaatt ggcattgcga ttccacatgg ctgggcgaca gagtcatcac caccagcacc      720

cgcacctggg ccctgcccac ctacaacaac cacctctaca agcagatatc aagtcagagc      780

ggggctacca acgacaacca cttcttcggc tacagcaccc cctggggcta ttttgacttc      840

aacagattcc actgccactt ctcaccacgt gactggcagc gactcatcaa caacaactgg      900

ggattccggc ccagaaagct gcggttcaag ttgttcaaca tccaggtcaa ggaggtcacg      960

acgaacgacg gcgttacgac catcgctaat aaccttacca gcacgattca ggtcttctcg     1020

gactcggagt accaactgcc gtacgtcctc ggctctgcgc accagggctg cctccctccg     1080

ttccctgcgg acgtgttcat gattcctcag tacggatatc tgactctaaa caacggcagt     1140

cagtctgtgg gacgttcctc cttctactgc ctggagtact ttccttctca gatgctgaga     1200

acgggcgata actttgaatt cagctacacc tttgaggaag tgcctttcca cagcagctat     1260

gcgcacagcc agagcctgga ccggctgatg aatcccctca tcgaccagta cctgtactac     1320

ctggcccgga cccagagcac tacggggtcc acaagggagc tgcagttcca tcaggctggg     1380

cccaacacca tggccgagca atcaaagaac tggctgcccg gaccctgtta tcggcagcag     1440

agactgtcaa aaaacataga cagcaacaac aacagtaact ttgcctggac cggggccact     1500

aaataccatc tgaatggtag aaattcatta accaacccgg gcgtagccat ggccaccaac     1560

aaggacgacg aggaccagtt ctttcccatc aacggagtgc tggtttttgg caaaacgggg     1620

gctgccaaca agacaacgct ggaaaacgtg ctaatgacca gcgaggagga gatcaaaacc     1680

accaatcccg tggctacaga agaatacggt gtggtctcca gcaacctgca atcgtctacg     1740

gccggacccc agacacagac tgtcaacagc cagggggctc tgcccggcat ggtctggcag     1800

aaccgggacg tgtacctgca gggtcccatc tgggccaaaa ttcctcacac ggacggcaac     1860

tttcacccgt ctcccctgat gggcggattt ggactcaaac acccgcctcc tcaaattctc     1920

atcaaaaaca ccccggtacc tgctaatcct ccagaggtgt ttactcctgc caagtttgcc     1980

tcatttatca cgcagtacag caccggccag gtcagcgtgg agatcgagtg ggaactgcag     2040

aaagaaaaca gcaaacgctg gaatccagag attcagtaca cctcaaatta tgccaagtct     2100

aataatgtgg aatttgctgt caacaacgaa ggggtttata ctgagcctcg ccccattggc     2160

acccgttacc tcacccgtaa cctgtaaatg gctgccgatg gttatcttcc agattggctc     2220

gaggacaacc tctctgaggg cattcgcgag tggtgggact tgaaacctgg agccccgaaa     2280

cccaaagcca accagcaaaa gcaggacgac ggccggggtc tggtgcttcc tggctacaag     2340

tacctcggac ccttcaacgg actcgacaag ggggagcccg tcaacgcggc ggacgcagcg     2400

gccctcgagc acgacaaggc ctacgaccag cagctcaaag cgggtgacaa tccgtacctg     2460

cggtataacc acgccgacgc cgagtttcag gagcgtctgc aagaagatac gtcttttggg     2520

ggcaacctcg ggcgagcagt cttccaggcc aagaagcggg ttctcgaacc tctcggtctg     2580

gttgaggaag gcgctaagac ggctcctgga aagaagagac cggtagagcc atcaccccag     2640

cgttctccag actcctctac gggcatcggc aagaaaggcc agcagcccgc gaaaaagaga     2700

ctcaactttg ggcagactgg cgactcagag tcagtgcccg accctcaacc aatcggagaa     2760

ccccccgcag gcccctctgg tctgggatct ggtacaatgg ctgcaggcgg tggcgctcca     2820

atggcagaca ataacgaagg cgccgacgga gtgggtagtt cctcaggaaa ttggcattgc     2880

gattccacat ggctgggcga cagagtcatc accaccagca cccgaacctg ggccctcccc     2940

acctacaaca accacctcta caagcaaatc tccaacggga cttcgggagg aagcaccaac     3000

gacaacacct acttcggcta cagcaccccc tgggggtatt ttgactttaa cagattccac     3060

tgccacttct caccacgtga ctggcagcga ctcatcaaca acaactgggg attccggccc     3120

aagagactca acttcaagct cttcaacatc caggtcaagg aggtcacgca gaatgaaggc     3180

accaagacca tcgccaataa ccttaccagc acgattcagg tctttacgga ctcggaatac     3240

cagctcccgt acgtcctcgg ctctgcgcac cagggctgcc tgcctccgtt cccggcggac     3300

gtcttcatga ttcctcagta cgggtacctg actctgaaca atggcagtca ggccgtgggc     3360

cgttcctcct tctactgcct ggagtacttt ccttctcaaa tgctgagaac gggcaacaac     3420

tttgagttca gctaccagtt tgaggacgtg ccttttcaca gcagctacgc gcacagccaa     3480

agcctggacc ggctgatgaa ccccctcatc gaccagtacc tgtactacct gtctcggact     3540

cagtccacgg gaggtaccgc aggaactcag cagttgctat tttctcaggc cgggcctaat     3600

aacatgtcgg ctcaggccaa aaactggcta cccgggccct gctaccggca gcaacgcgtc     3660

tccacgacac tgtcgcaaaa taacaacagc aactttgcct ggaccggtgc caccaagtat     3720

catctgaatg gcagagactc tctggtaaat cccggtgtcg ctatggcaac ccacaaggac     3780

gacgaagagc gattttttcc gtccagcgga gtcttaatgt ttgggaaaca gggagctgga     3840

aaagacaacg tggactatag cagcgttatg ctaaccagtg aggaagaaat taaaaccacc     3900

aacccagtgg ccacagaaca gtacggcgtg gtggccgata acctgcaaca gcaaaacgcc     3960

gctcctattg taggggccgt caacagtcaa ggagccttac ctggcatggt ctggcagaac     4020

cgggacgtgt acctgcaggg tcctatctgg gccaagattc ctcacacgga cggaaacttt     4080

catccctcgc cgctgatggg aggctttgga ctgaaacacc cgcctcctca gatcctgatt     4140

aagaatacac ctgttcccgc ggatcctcca actaccttca gtcaagctaa gctggcgtcg     4200

ttcatcacgc agtacagcac cggacaggtc agcgtggaaa ttgaatggga gctgcagaaa     4260

gaaaacagca aacgctggaa cccagagatt caatacactt ccaactacta caaatctaca     4320

aatgtggact ttgctgttaa cacagatggc acttattctg agcctcgccc catcggcacc     4380

cgttacctca cccgtaatct gtaa                                            4404


<210> 4990
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4990
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Asp 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4991
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 4991
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Asp 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 4992
<211> 2501
<212> DNA
<213> Adeno-associated virus

<400> 4992
gaattcgccc ttggctgcgt caactggacc aatgagaact ttcccttcaa cgattgcgtc       60

gacaagatgg tgatctggtg ggaggagggc aagatgacgg ccaaggtcgt ggagtccgcc      120

aaggccattc atcatctgct ggggcgggct cccgagattg cttgctcggc ctgcgatctg      180

gtcaacgtgg acctggatga ctgtgtttct gagcaataaa tgacttaaac caggtatggc      240

tgccgatggt tatcttccag attggctcga ggacaacctc tctgagggca ttcgcgagtg      300

gtgggacttg agacctggag ccccgaaacc caaagccaac cagcaaaagc aggacgacgg      360

ccggggtctg gtgcttcctg gctacaagta cctcggaccc ttcaacggac tcgacaaggg      420

agagccggtc aacgaggcag acgccgcggc cctcgagcac gacaaggcct acgacaagca      480

gctcgagcag ggggacaacc cgtacctcaa gtacaaccac gccgacgccg agtttcagga      540

gcgtcttcaa gaagatacgt cttttggggg caacctcggg cgagcagtct tccaggccaa      600

gaagcgggtt ctcgaacctc tcggtctggt tgaggaaggc gctaagacgg ctcctggaaa      660

gaagagaccc atagaatccc ccgactcctc cacgggcatc ggcaagaaag gccagcagcc      720

cgctaaaaag agactcaact ttgggcagac tggcgactca gagtcagtgc ccgaccctca      780

accaatcgga gaaccccccg caggcccctc tggtctggga tctggcacaa tggctgcagg      840

cggtggcgct ccaatggcag acaataacga aggcgccgac ggagtgggta gttcctcagg      900

aaattggcat tgcgattcca catggctggg cgacagagtc atcaccacca gcacccgaac      960

ctgggccctc cccacctaca acaaccacct ctacaagcaa atctccaacg ggacatcggg     1020

aggaagcacc aacgacaaca cctacttcgg ctacagcacc ccctgggggt attttgactt     1080

taacagattc cactgccact tctcaccacg tgactggcag cgactcatca acaacaactg     1140

gggattccgg cccaagagac tcaacttcaa gctcttcaac atccaggtca aggaggtcac     1200

gcagaatgaa ggcaccaaga ccatcgccaa taaccttacc agcacgattc aggtctttac     1260

ggactcggaa taccagctcc cgtacgtcct cggctctgcg caccagggct gcctgcctcc     1320

gttcccggcg gacgtcttca tgattcctca gtacgggtac ctgactctga acaacggcag     1380

tcaggccgtg ggccgttcct ccttctactg cctggagtac tttccttctc aaatgctgag     1440

aacgggcaac aactttgagt tcagctacca gtttgaggac gtgccttttc acagcagcta     1500

tgcgcacagc caaagcctgg accggctgat gaaccccctc atcgaccagt acctgtacta     1560

cctgtctcgg actcagtcca cgggaggtac cgcaggaact cagcagttgc tattttctca     1620

ggccgggcct aataacatgt cggctcaggc caaaaactgg ctacccgggc cctgctaccg     1680

gcagcaacgc gtctccacga cagtgtcgca aaataacaac agcaactttg cttggaccgg     1740

tgccaccaag tatcatctga atggcagaga ctctctggta aatcccggtg tcgctatggc     1800

aacgcacaag ggcgacgaag agcgattttt tccatccagc ggagtcttga tgtttgggaa     1860

acagggagct ggaaaagaca acgtagacta tagcagcgtt atgctaacca gtgaggaaga     1920

aatcaaaacc accaacccag tggccacaga acagtacggc gtggtggccg ataacctgca     1980

acagcaaaac gccgctccta ttgtaggggc cgtcaacagt caaggagcct tacctggcat     2040

ggtctggcag aaccgggacg tgtacctgca gggtcctatc tgggccaaga ttcctcacac     2100

ggacggcaac tttcatcctt cgccgctgat gggaggcttt ggactgaaac acccgcctcc     2160

tcagatcctg attaagaata cacctgttcc cgcggatcct ccaactacct tcagtcaagc     2220

caagctggcg tcgttcatca cgcagtacag caccggacag gtcagcgtgg aaattgaatg     2280

ggagctgcag aaagagaaca gcaagcgctg gaacccagag attcagtata cttccaacta     2340

ctacaaatct acaaatgtgg actttgctgt caatactgag ggtacttatt cagagcctcg     2400

ccccattggc acccgttacc tcacccgtaa cctgtaattg cctgttaatc aataaaccgg     2460

ttgattcgtt tcagttgaac tttggtctca agggcgaatt c                         2501


<210> 4993
<211> 2187
<212> DNA
<213> Adeno-associated virus

<400> 4993
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

aagcagctcg agcaggggga caacccgtac ctcaagtaca accacgccga cgccgagttt      300

caggagcgtc ttcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gacccataga atcccccgac tcctccacgg gcatcggcaa gaaaggccag      480

cagcccgcta aaaagaagct caactttggg cagactggcg actcagagtc agtgcccgac      540

ccccaacctc tcggagaacc tcccgccgcg ccctcaggtc tgggatctgg tacaatggct      600

gcaggcggtg gcgcaccaat ggcagacaat aacgaaggcg ccgacggagt gggtaatgcc      660

tccggaaatt ggcattgcga ttccacatgg ctgggcgaca gagtcatcac caccagcacc      720

cgcacctggg ccctgcccac ctacaacaac cacctctaca agcagatatc aagtcagagc      780

ggggctacca acgacaacca cttcttcggc tacagcaccc cctggggcta ttttgacttc      840

aacagattcc actgccactt ctcaccacgt gactggcagc gactcatcaa caacaactgg      900

ggattccggc ccagaaagct gcggttcaag ttgttcaaca tccaggtcaa ggaggtcacg      960

acgaacgacg gcgttacgac catcgctaat aaccttacca gcacgattca ggtcttctcg     1020

gactcggagt accaactgcc gtacgtcctc ggctctgcgc accagggctg cctccctccg     1080

ttccctgcgg acgtgttcat gattcctcag tacggatatc tgactctaaa caacggcagt     1140

cagtctgtgg gacgttcctc cttctactgc ctggagtact ttccttctca gatgctgaga     1200

acgggcaata actttgaatt cagctacacc tttgaggaag tgcctttcca cagcagctat     1260

gcgcacagcc agagcctgga ccggctgatg aatcccctca tcgaccagta cctgtactac     1320

ctggcccgga cccagagcac tacggggtcc acaagggagc tgcagttcca tcaggctggg     1380

cccaacacca tggccgagca atcaaagaac tggctgcccg gaccctgtta tcggcagcag     1440

agactgtcaa aaaacataga cagcaacaac aacagtaact ttgcctggac cggggccact     1500

aaataccatc tgaatggtag aaattcatta accaacccgg gcgtagccat ggccaccaac     1560

aaggacgacg aggaccagtt ctttcccatc aacggagtgc tggtttttgg cgaaacgggg     1620

gctgccaaca agacaacgct ggaaaacgtg ctaatgacca gcgaggagga gatcaaaacc     1680

accaatcccg tggctacaga agaatacggt gtggtctcca gcaacctgca atcgtctacg     1740

gccggacccc agacacagac tgtcaacagc cagggggctc tgcccggcat ggtctggcag     1800

aaccgggacg tgtacctgca gggtcccatc tgggccaaaa ttcctcacac ggacggcaac     1860

tttcacccgt ctcccctgat gggcggattt ggactcaaac acccgcctcc tcaaattctc     1920

atcaaaaaca ccccggtacc tgctaatcct ccagaggtgt ttactcctgc caagtttgcc     1980

tcatttatca cgcagtacag caccggccag gtcagcgtgg agatcgagtg ggaactgcag     2040

aaagaaaaca gcaaacgctg gaatccagag attcagtaca cctcaaatta tgccaagtct     2100

aataatgtgg aatttgctgt caacaacgaa ggggtttata ctgagcctcg ccccattggc     2160

acccgttacc tcacccgtaa cctgtaa                                         2187


<210> 4994
<211> 728
<212> PRT
<213> Adeno-associated virus

<400> 4994
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Glu Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210> 4995
<211> 728
<212> PRT
<213> Adeno-associated virus

<400> 4995
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210> 4996
<211> 728
<212> PRT
<213> Adeno-associated virus

<400> 4996
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Lys Gln Leu Glu Gln Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Glu Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His Phe Phe Gly Tyr Ser 
            260                 265                 270         


Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser 
        275                 280                 285             


Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro 
    290                 295                 300                 


Arg Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr 
305                 310                 315                 320 


Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile 
                325                 330                 335     


Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser 
            340                 345                 350         


Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile 
        355                 360                 365             


Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val Gly 
    370                 375                 380                 


Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr Thr 
        435                 440                 445             


Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr Met 
    450                 455                 460                 


Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
465                 470                 475                 480 


Arg Leu Ser Lys Asn Ile Asp Ser Asn Asn Asn Ser Asn Phe Ala Trp 
                485                 490                 495     


Thr Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr Asn 
            500                 505                 510         


Pro Gly Val Ala Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe Phe 
        515                 520                 525             


Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn Lys 
    530                 535                 540                 


Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn Leu 
                565                 570                 575     


Gln Ser Ser Thr Ala Gly Pro Gln Thr Gln Thr Val Asn Ser Gln Gly 
            580                 585                 590         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr Pro 
                645                 650                 655     


Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val Glu 
    690                 695                 700                 


Phe Ala Val Asn Asn Glu Gly Val Tyr Thr Glu Pro Arg Pro Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210> 4997
<211> 3113
<212> DNA
<213> Adeno-associated virus

<400> 4997
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaagg tgcgcgtgga ccaaaagtgc aagtcgtccg      180

cccagatcga tcccaccccc gtgatcgtca cttccaacac caacatgtgc gccgtgattg      240

acgggaacag caccaccttc gagcaccagc agccgttaca agaccggatg ttcaaatttg      300

aactcacccg ccgtctggag catgactttg gcaaggtgac aaagcaggaa gtcaaagagt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca tgagttctac gtcagaaagg      420

gtggagccaa caagagaccc gcccccgatg acgcggataa aagcgagccc aagcgggcct      480

gcccctcagt cgcggatcca tcgacgtcag acgcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg cttccctgca      600

agacatgcga gagaatgaat cagaatttca gcatttgctt cacgcacggg accagagact      660

gttcagaatg tttccccggc gtgtcagaat ctcaaccggt cgtcagaaag aggacgtatc      720

ggaaactctg tgccattcat catctgctgg ggcgggctcc cgagattgct tgctcggcct      780

gcgatctggt caacgtggac ctggatgact gtgtttctga gcaataaatg acttaaacca      840

ggtatggctg ccgatggtca tcttccagat tggctcgagg acaacctctc tgagggcatt      900

cgcgagtggt gggacttgaa acctggagcc ccgaaaccca aagccaacca gcaaaagcag      960

gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt caacggactc     1020

gacaaggggg agcccgtcaa cgcggcggac gcagcggccc tcgagcacga caaggcctac     1080

gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc cgacgccgag     1140

tttcaggagc gtcttcaaga agatacgtct tttgggggca acctcgggcg agcagtcttc     1200

caggccaaga agcgggttct cgaacctctc ggtctggttg aggaaggcgc taagacggct     1260

cctggaaaga agagacccat agaatccccc gactcctcca cgggcatcgg caagaaaggc     1320

cagcagcccg ctaaaaagaa gctcaacttt gggcagactg gcgactcaga gtcagtgccc     1380

gaccctcaac caatcggaga accccccgca ggcccctctg gtctgggatc tggtacaatg     1440

gctgcaggcg gtggcgctcc aatggcagac aataacgaag gcgccgacgg agtgggtagt     1500

tcctcaggaa attggcattg cgattccaca tagctgggcg acagagtcat caccaccagc     1560

acccgaacct gggccctccc cacctacaac aaccacctct acaagcaaat ctccaacggg     1620

acatcgggag gaagcaccaa cgacaacacc tacttcggct acagcacccc ctgggggtat     1680

tttgacttta acagattcca ctgccacttc tcaccacgtg actggcagcg actcatcaac     1740

aacagctggg gattccggcc caagagactc aacttcaagc tcttcaacat ccaggtcaag     1800

gaggtcacgc agaatgaagg caccaagacc atcgccaata accttaccag cacgattcag     1860

gtctttacgg actcggaata ccagctcccg tacgtcctcg gctctgcgca ccagggctgc     1920

ctgcctccgt tcccggcgga cgtcttcatg attcctcagt acgggtacct gactctgaac     1980

aacggcagtc aggccgtggg ccgttcctcc ttctactgcc tggagtactt tccttctcaa     2040

atgctgagaa cgggcaacaa ctttgagttc agctaccagt ttgaggacgt gccttttcac     2100

agcagctacg cgcacagcca aagcctggac cggctgatga accccctcat cgaccagtac     2160

ctgtactacc tgtctcggac tcagtccacg ggaggtaccg caggaactca gcagttgcta     2220

ttttctcagg ccgggcctaa taacatgtcg gctcaggcca aaaactggct acccgggccc     2280

tgctaccggc agcaacgcgt ctccacgaca ctgtcgcaaa ataacaacag caactttgct     2340

tggaccggtg ccaccaagta tcatctgaat ggcagagact ctctggtaaa tcccggtgtc     2400

gctatggcaa cgcacaagga cgacgaagag cgattttttc catccagcgg agtcttgatg     2460

tttgggaaac agggagctgg aaaagacaac gtggactata gcagcgttat gctaaccagt     2520

gaggaagaaa tcaaaaccac caacccagtg gccacagaac agtacggcgt ggtggccgat     2580

aacctgcaac agcaaaacgc cgctcctatt gtaggggccg tcaacagtca aggagcctta     2640

cctggcatgg tctggcagaa ccgggacgtg tacctgcagg gtcctatctg ggccaagatt     2700

cctcacacgg acggcaactt tcatccttcg ccgctgatgg gaggctttgg actgaaacac     2760

ccgcctcctc agatcctgat taagaataca cctgttcccg cggatcctcc aactaccttc     2820

agtcaagcca agctggcgtc gttcatcacg cagtacagca ccggacaggt cagcgtggaa     2880

attgaatggg agctgcagaa agagaacagc aagcgctgga acccagagat tcagtatact     2940

tccaactact acaaatctac aaatgtggac tttgctgtca atactgaggg tacttattca     3000

gagcctcgcc ccattggcac ccgttacctc acccgtaacc tgtaattgcc tgttaatcaa     3060

taaaccggtt aattcgtttc agttgaactt tggtctctgc gaagggcgaa ttc            3113


<210> 4998
<211> 3106
<212> DNA
<213> Adeno-associated virus

<400> 4998
gaattcgccc ttctacggct gcgtcaactg gaccaatgag aactttccct tcaacgattg       60

cgtcgacaag atggtgatct ggtgggagga gggcaagatg acggccaagg tcgtggagtc      120

cgccaaggcc attctcggcg gcagcaaggt gcgcgtggac caaaagtgca agtcgtccgc      180

ccagatcgac cccacccccg tgatcgtcac ctccaacacc aacatgtgcg ccgtgattga      240

cgggaacagc accaccttcg agcaccagca gccgttgcag gaccggatgt tcaaatttga      300

actcacccgc cgtctggagc atgactttgg caaggcgaca aagcaggaag tcaaagagtt      360

cttccgctgg gcgcaggatc acgtgaccga ggtggcgcat gagttctacg tcagaaaggg      420

tggagccaac aagagacccg cccccgatga cgcggataaa agcgagccca agcgggcccg      480

cccctcagtc gcggatccat cgacgtcaga cgcggaagga gctccggtgg actttgccga      540

caggtaccaa aacaaatgtt ctcgtcacgc gggcatgctt cagatgctgt ttccctgcaa      600

aacatgcgag agaatgaatc agaatttcaa catttgcttc acgcacggga ccagagactg      660

ttcagaatgt ttccccggcg tgtcagaatc tcaaccggtc gtcagaaaga ggacgtatcg      720

gaaactctgt gccattcatc atctgctggg gcgggctccc gagattgctt gctcggcctg      780

cgatctggtc aacgtggacc tggatgactg tgtttctgag caataaatga cttaaaccag      840

gtatggctgc cgatggttat cttccagatt ggctcgagga caacctctct gagggcattc      900

gcgagtggtg ggacttgaaa cctggagccc cgaaacccaa agccaaccag caaaagcagg      960

acgacggccg gggtctggtg cttcctggct acaagtacct cggacccttc aacggactcg     1020

acaagggaga gccggtcaac gaggcagacg ccgcggccct cgagcacgac aaggcctacg     1080

acaagcagct cgagcagggg gacaacccgt acctcaagta caaccacgcc gacgccgagt     1140

ttcaggagcg tcttcaagaa gatacgtctt ttgggggcaa cctcgggcga gcagtcttcc     1200

gggccaagaa gcgggttctc gaacctctcg gtctggttga ggaaggcgct aagacggctc     1260

ctggaaagaa gagacccata gaatcccccg actcctccac gggcatcggc aagaaaggcc     1320

agcagcccgc taaaaagaag ctcaactttg ggcagactgg cgactcagag tcagtgcccg     1380

acccccaacc tctcggagaa cctcccgccg cgccctcagg tctgggatct ggtacaatgg     1440

ctgcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga gtgggtaatg     1500

cctccggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc accaccagca     1560

cccgcacctg ggccctgccc acctacaaca accacctcta caagcagata tcaagtcaga     1620

gcggggctac caacgacaac cacttcttcg gctacagcac cccctggggc tattttgact     1680

tcaacagatt ccactgccac ttctcaccac gtgactggca gcgactcatc aacaacaacc     1740

ggggattccg gcccagaaag ctgcggttca agttgttcaa catccaggtc aaggaggtca     1800

cgacgaacga cggcgttacg accatcgcta ataaccttac cagcacgatt caggtcttct     1860

cggactcgga gtaccaactg ccgtacgtcc tcggctctgc gcaccagggc tgcctccctc     1920

cgttccctgc ggacgtgttc atgattcctc agtacggata tctgactcta aacaacggca     1980

gtcagtctgt gggacgttcc tccttctact gcctggagta ctttccttct cagatgctga     2040

gaacgggcaa taactttgaa ttcagctacc agtttgagga cgtgcccttt cacagcagct     2100

acgcgcacag ccaaagcctg gaccggctga tgaaccccct catcgaccag tacctgtact     2160

acctgtctcg gactcagtcc acgggaggta ccgcaggaac tcagcagttg ctattttctc     2220

aggccgggcc taataacatg tcggctcagg ccaaaaactg gctacccggg ccctgctacc     2280

ggcagcaacg cgtctccacg acactgtcgc aaaataacaa cagcaacttt gcttggaccg     2340

gtgccaccaa gtatcatctg aatggcagag actctctggt aaatcccggt gtcgctatgg     2400

caacgcacaa ggacgacgaa gagcgatttt ttccatccag cggagtcttg atgtttggga     2460

aacagggagc tggaaaagac aacgtggact atagcagcgt tatgctaacc agtgaggaag     2520

aaatcaaaac caccaaccca gtggccacag aacagtacgg cgtggtggcc gataacctgc     2580

aacagcaaaa cgccgctcct attgtagggg ccgtcaacag tcaaggagcc ttacctggca     2640

tggcctggca gaaccgggac gtgtacctgc agggtcctat ctgggccaag attcctcaca     2700

cggacggcaa ctttcatcct tcgccgctga tgggaggctt tggactgaaa cacccgcctc     2760

ctcagatcct gattaagaat acacctgttc ccgcggatcc tccaactacc ttcagtcaag     2820

ccaagctggc gtcgttcatc acgcagtaca gcaccggaca ggtcagcgtg gaaattgaat     2880

gggagctgca gaaagagaac agcaagcgct ggaacccaga gattcagtat acttccaact     2940

actacaaatc tacaaatgtg gactttgctg tcaatactga gggtacttat tcagagcctc     3000

gccccattgg cacccgttac ctcacccgta acctgtaatt gcctgttaat caataaaccg     3060

gttaattcgt ttcagttgaa ctttggtctc tgcgaagggc gaattc                    3106


<210> 4999
<211> 3197
<212> DNA
<213> Adeno-associated virus

<400> 4999
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaagg tgcgcgtgga ccaaaagtgc aagtcgtccg      180

cccagatcga ccccaccccc gtgatcgtca cctccaacac caacatgtgc gccgtgattg      240

acgggaacag caccaccttc gagcaccagc agccgttaca agaccggatg ttcaaatttg      300

aactcacccg ccgtctggag cacgactttg gcaaggtgac aaagcaggaa gtcaaagagt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca tgagttctac gtcagaaagg      420

gtggagccaa caagagaccc gcccccgatg acgcggataa aagcgagccc aagcgggcct      480

gcccctcagt cgcggatcca tcgacgtcag acgcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg tttccctgca      600

agacatgcga gagaatgaat cagaatttca acatttgctt cacgcacggg accagagact      660

gttcagaatg tttccccggc gtgtcagaat ctcaaccggt cgtcagaaag aggacgtatc      720

ggaaactctg tgccattcat catctgctgg ggcgggctcc cgagattgct tgctcggcct      780

gcgatctggt caacgtggac ctggatgact gtgtttctga gcaataaatg acttaaacca      840

ggtatggctg ccgatggtta tcttccagat tggctcgagg acaacctctc tgagggcatt      900

cgcgagtggt gggacttgaa acctggagcc ccgaaaccca aagccaacca gcaaaagcag      960

gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt caacggactc     1020

gacaagggag agccggtcaa cgaggcagac gccgcggccc tcgagcacga caaggcctac     1080

gacaagcagc tcgagcaggg ggacaacccg tacctcaagt acaaccacgc cgacgccgag     1140

tttcaggagc gtcttcaaga agatacgtct tttgggggca acctcgggcg agcagtcttc     1200

caggccaaga agcgggttct cgaacctctc ggtctggttg aggaaggcgc taagacggct     1260

cctggaaaga agagaccggt agagccatca ccccagcgtt ctccagactc ctctacgggc     1320

atcggcaaga caggccagca gcccgcgaaa aagagactca actttgggca gactggcgac     1380

tcagagtcag tgcccgaccc tcaaccaatc ggagaacccc ccgcaggccc ctctggtctg     1440

ggatctggta caatggctgc aggcggtggc gctccaatgg cagacaataa cgaaggcgcc     1500

gacggagtgg gtagttcctc aggaaattgg cattgcgatt ccacatggct gggcgacaga     1560

gtcatcacca ccagcacccg aacctgggcc ctccccacct acaacaacca cctctacaag     1620

caaatctcca acgggacatc gggaggaagc accaacgaca acacctactt cggctacagc     1680

accccctggg ggtattttga ctttaacaga ttccactgcc acttctcacc acgtgactgg     1740

cagcgactca tcaacaacaa ctggggattc cggcccaaga gactcaactt caagctcttc     1800

aacatccagg tcaaggaggt cacgcagaat gaaggcacca agaccatcgc caataacctt     1860

accagcacga ttcaggtctt tacggactcg gaataccagc tcccgtacgt cctcggctct     1920

gcgcaccagg gctgcctgcc tccgttcccg gcggacgtct tcatgattcc tcagtacggg     1980

tacctgactc tgaacaacgg cagtcaggcc gtgggccgtt cctccttcta ctgcctggag     2040

tactttcctt ctcaaatgct gagaacgggc aacaactttg agttcagcta ccagtttgag     2100

gacgtgcctt ttcacagcag ctacgcgcac agccaaagcc tggaccggct gatgaacccc     2160

ctcatcgacc agtacctgta ctacctgtct cggactcagt ccacgggagg taccgcagga     2220

actcagcagt tgctattttc tcaggccggg cctaataaca tgtcggctca ggccaaaaac     2280

tggctacccg ggccctgcta ccggcagcaa cgcgtctcca cgacactgtc gcaaaataac     2340

aacagcaact ttgcttggac cggtgccacc aagtatcatc tgaatggcag agactctctg     2400

gtaaatcccg gtgtcgctat ggcaacgcac aaggacgacg aagagcgatt ttttccatcc     2460

agcggagtct tgatgtttgg gaaacaggga gctggaaaag acaacgtgga ctatagcagc     2520

gttatgctaa ccagtgagga agaaatcaaa accaccaacc cagtggccac agaacagtac     2580

ggcgtggtgg ccgataacct gcaacagcaa aacgccgctc ctattgtagg ggccgtcaac     2640

agtcaaggag ccttacctgg catggtctgg cagaaccggg acgtgtacct gcagggtcct     2700

atctgggcca agattcctca cacggacggc aactttcatc cttcgccgct gatgggaggc     2760

tttggactga aacacccgcc tcctcagatc ctgattaaga atacacctgt tcccgcggat     2820

cctccaacta ccttcagtca agccaagctg gcgtcgttca tcacgcagta cagcaccgga     2880

caggtcagcg tggaaattga atgggagctg cagaaagaga acagcaagcg ctggaaccca     2940

gagattcagt atacttccaa ctactacaaa tctacaaatg tggactttgc tgtcaatact     3000

gagggtactt attcagagcc tcgccccatt ggcacccgtt acctcacccg taacctgtaa     3060

ttgcctgtta atcaataaac cggttaattc gtttcagttg aactttggtc tctgcgaagg     3120

gcgaattcgt ttaaacctgc aggactagtc cctttagtga gggttaattc tgagcttggc     3180

gtaatcatgg gtcatag                                                    3197


<210> 5000
<211> 3276
<212> DNA
<213> Adeno-associated virus

<400> 5000
gaattcgccc ttcgcagaga ccaaagttca actgaaacga attaaccggt ttattgatta       60

acaggcaatt acaggttacg ggtgaggtaa cgggtgccaa tggggcgagg ctcagtataa      120

accccttcgt tgttgacagc aaattccaca ttattagact tggcataatt tgaggtgtac      180

tgaatctctg gattccagcg tttgctgttt tctttctgca gttcccactc gatctccacg      240

ctgacctggc cggtgctgta ctgcgtgata aatgaggcaa acttggcagg agtaaacacc      300

tctggaggat tagcaggtac cggggtgttt ttgatgagaa tttgaggagg cgggtgtttg      360

agtccaaatc cgtccatcag gggagacggg tgaaagttgc cgtccgtgtg aggaattttg      420

gcccagatgg gaccctgcag gtacacgtcc cggttctgcc agaccatgcc gggcagagcc      480

ccctggctgt tgacagtctg tgtctggggt ccggccgtag acgattgcag gttgctggag      540

accacaccgt attcttctgt agccacggga ttggtggttt tgatctcctc ctcgctggtc      600

attagcacgt tttccagcgt tgtcttgttg gcagcccccg ttttgccaaa aaccagcact      660

ccgttgatgg gaaagaactg gtcctcgtcg tccttgttgg tggccatggc tacgcccggg      720

ttggttaatg aatttctacc attcagatgg tatttagtgg ccccggtcca ggcaaagtta      780

ctgttgttgt tgctgtctat gttttttgac agtctctgct gccgataaca gggtccgggc      840

agccagttct ttgattgctc ggccatggtg ttgggcccag cctgatggaa ctgcagctcc      900

cttgtggacc ccgtagtgct ctgggtccgg gccaggtagt acaggtactg gtcgatgagg      960

ggattcatca gccggtccag gctctggcta tgcgcatagc tgctgtggaa aggcacttcc     1020

tcaaaggtgt agctgaattc aaagttattg cccgttctca gcatctgaga aggaaagtac     1080

tccaggcagt agaaggagga acgtcccaca gactgactgc cgttgtttag agtcagatat     1140

ccgtactgag gaatcatgaa cacgtccgca gggaacggag ggaggcagcc ctggtgcgca     1200

gagccgagga cgtacggcag ttggtactcc gagtccgaga agacctgaat cgtgctggta     1260

aggttattag cgatggtcgt aacgccgtcg tccgtcgtga cctccttgac ctggatgttg     1320

aacaacttga accgcagctt tctgggccgg aatccccagt tgttgttgat gagtcgctgc     1380

cagtcacgtg gtgagaagtg gcagtggaat ctgttaaagt caaaataccc ccagggggtg     1440

ctgtagccga agtaggtgtt gtcgttggtg cttcctcccg atgtcccgtt ggagatttgc     1500

ttgtagaggt ggttgttgta ggtggggagg gcccaggttc gggtgctggt ggtgatgact     1560

ctgtcgccca gccatgtgga atcgcaatgc caatttcctg aggaactacc cactccgtcg     1620

gcgccttcgt tattgtctgc cattggagcg ccaccgcctg cagccattgt accagatccc     1680

agaccagagg ggcctgcggg gggttctccg attggttgag ggtcgggcac tgactctgag     1740

tcgccagtct gcccaaagtt gagtctcttt ttcgcgggct gctggcctgt cttgccgatg     1800

cccgtagagg agtctggaga acgctggggt gatggctcta ccggtctctt ctttccagga     1860

gccgtcttag cgccttcctc aaccagaccg agaggttcga gaacccgctt cttggcctgg     1920

aagactgctc gcccgaggtt gcccccaaaa gacgtatctt cttgaagacg ctcctgaaac     1980

tcggcgtcgg cgtggttgta cttgaggtac gggttgtccc cctgctcgag ctgcttgtcg     2040

taggccttgt cgtgctcgag ggccgcggcg tctgcctcgt tgaccggctc tcccttgtcg     2100

agtccgttga agggtccgag gtacttgtag ccaggaagca ccagaccccg gccgtcgtcc     2160

tgcttttgct ggttggcttt gggtttcggg gctccaggtt tcaagtccca ccactcgcga     2220

atgccctcag agaggttgtc ctcgagccaa tctggaagat aaccatcggc agccatacct     2280

ggtttaagtc atttattgct cagaaacaca gtcatccagg tccacgttga ccagatcgca     2340

ggccgagcaa gcaatctcgg gagcccgccc cagcagatga tgaatggcac agagtttccg     2400

atacgtcctc tttctgacga ccggttgaga ttctgacacg ccggggaaac attctgaaca     2460

gtctctggtc ccgtgcgtga agcaaatgtt gaaattctga ttcattctct cgcatgtctt     2520

gcagggaaac agcatctgaa gcatgcccgc gtgacgagaa cacttgtttt ggtacctgtc     2580

ggcaaagtcc accggagctc cttccgcgtc tgacgtcgat ggatgcaaaa tgtcgcaaaa     2640

gcactcacgt gacagctaat acaggaccac tcccctatga cgtgatttac gtcagcgcta     2700

tgcccgcgtg acgagaacat ttgttttggt acctgtcggc aaagtccacc ggagctcctt     2760

ccgcgtctga cgtcgatgga tccgcgactg aggggcaggc ccgcttgggc tcgcttttat     2820

ccgcgtcatc gggggcgggt ctcttgttgg ctccaccctt tctgacgtag aactcatgcg     2880

ccacctcggt cacgtgatcc tgcgcccagc ggaagaactc tttgacttcc tgctttgtca     2940

ccttgccaaa gtcatgctcc agacggcggg tgagttcaaa tttgaacatc cggtcctgca     3000

acggctgctg gtgctcgaag gtggtgctgt tcccgtcaat cacggcgcac atgttggtgt     3060

tggaagtgac gatcacgggg gtgggatcga tctgggcgga agacttgcac ttttggtcca     3120

cgcgcacctt gctgccgccg agaatggcct tggcggactc cacgaccttg gccgtcatct     3180

tgccctcctc ccaccagatc accatcttgt cgacgcaatc gttgaaggga aagttctcat     3240

tggtccagtt gacgcagccg tagaaagggc gaattc                               3276


<210> 5001
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5001
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly His Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Pro Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Gly Ala 
            580                 585                 590         


Pro Ile Val Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Val Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5002
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5002
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly His Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Pro Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Gly Ala 
            580                 585                 590         


Pro Ile Val Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5003
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5003
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5004
<211> 2489
<212> DNA
<213> Adeno-associated virus

<400> 5004
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtgaagt      120

ccgccaaggc cattcatcat ctgctggggc gggctcccga gattgcttgc tcggcctgcg      180

atctggtcaa cgtggacctg gatgactgtg tttctgagca ataaatgact taaaccaggt      240

atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc      300

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      360

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      420

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      480

aagcagctcg agcaggggga caacccgtac ctcaagtaca accacgccga cgccgagttt      540

caggagcgtc ttcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      600

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      660

ggaaagaaga gacccataga atcccccgac tcctccacgg gcatcggcag gaaaggccag      720

cagcccgcta aaaagaagct caactttggg cagactggcg actcagagtc agtgcccgac      780

cctcaaccaa tcggagaacc ccccgcaggc ccctctggtc tgggatctgg tacaatggct      840

gcaggcggtg gcgctccaat ggcagacaat aacgaaggcg ccgacggagt gggtaatgcc      900

tccggaaatt ggcattgcga ttccacatgg ctgggcgaca gagtcatcac caccagcacc      960

cgcacctggg ccctgcccac ctacaacaac cacctctaca agcagatatc aagtcagagc     1020

ggggctacca acgacaacca cttcttcggc tacagcaccc cctggggcta ttttgacttc     1080

aacagattcc actgccactt ctcaccacgt gactggcagc gactcatcaa caacaactgg     1140

ggattccggc ccagaaagct gcggttcaag ttgttcaaca tccaggtcaa ggaggtcacg     1200

acgaacgacg gcgttacgac catcgccaat aaccttacca gcacgattca ggtcttctcg     1260

gactcggagt accaactgcc gtacgtcctc ggctctgcgc accagggctg cctccctccg     1320

ttccctgcgg acgtgttcat gattcctcag tacggatatc tgactctaaa caacggcagt     1380

cagtctgtgg gacgttcctc cttctactgc ctggagtact ttccttctca gatgctgaga     1440

acgggcaata actttgaatt cagctacacc tttgaggaag tgcctttcca cagcagctat     1500

gcgcacagcc agagcctgga ccggctgatg aatcccctca tcgaccagta cctgtactac     1560

ctggcccgga cccagagcac tacggggtcc acaagggagc tgcagttcca tcaggctggg     1620

cccaacacca tggccgagca atcaaagaac tggctgcccg gaccctgtta tcggcagcag     1680

agactgtcaa aaaacataga cagcaacaac aacagtaact ttgcctggac cggggccact     1740

aaataccatc tgaatggtag aaattcatta accaacccgg gcgtagccat ggccaccaac     1800

aaggacgacg aggaccagtt ctttcccatc aacggagtgc tggtttttgg caaaacgggg     1860

gctgccaaca agacaacgct ggaaaacgtg ctaatgacca gcgaggagga gatcaaaacc     1920

accaatcccg tggctacaga agaatacggt gtggtctcca gcaacctgca atcgtctacg     1980

gccggacccc agacacagac tgtcaacagc cagggggctc tgcccggcat ggtctggcag     2040

aaccgggacg tgtacctgca gggtcccatc tgggccaaaa ttcctcacac ggacggcaac     2100

tttcacccgt ctcccctgat gggcggattt ggactcaaac acccgcctcc tcaaattctc     2160

atcaaaaaca ccccggtacc tgctaatcct ccagaggtgt ttactcctgc caagtttgcc     2220

tcatttatca cgcagtacag caccggccag gtcagcgtgg agatcgagtg ggaactgcag     2280

aaagaaaaca gcaaacgctg gaatccagag attcagtaca cctcaaatta tgccaagtct     2340

aataatgtgg aatttgctgt caacaacgaa ggggtttata ctgagcctcg ccccattggc     2400

acccgttacc tcacccgtaa cctgtaattg cctgttaatc aataaaccgg ttaattcgtt     2460

tcagttgaac tttggtcaag ggcgaattc                                       2489


<210> 5005
<211> 3098
<212> DNA
<213> Adeno-associated virus

<400> 5005
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaagg tgcgcgtgga ccaaaagtgc aagtcttccg      180

cccagatcga tcccaccccc gtgatcgtca cttccaacac caacatgtgc gccgtgattg      240

acgggaacag caccaccttc gagcaccagc agccgttaca agaccggatg ttcaaatttg      300

aactcacccg ccgtctggag cacgactttg gcaaggtgac aaagcaggaa gtcaaagagt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca tgagttctac gtcagaaagg      420

gtggagccaa caagagaccc gcccccgatg acgcggataa aagcgagccc aagcgggcct      480

gcccctcagt cgcggatcca tcgacgtcag acgcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg tttccctgca      600

agacatgcga gagaatgaat cagaatttca acatttgctt cacgcacggg accggagact      660

gttcagaatg tttccccggc gtgtcagaat ctcaaccggt cgtcagaaag aggacgtatc      720

ggaaactctg tgccattcat catctgctgg ggcgggctcc cgagattgct tgctcggcct      780

gcgatctggt caacgtggac ctggatgact gtgtttctga gcaataaatg acttaaacca      840

ggtatggctg ccgatggtta tcttccagat tggctcgagg acaacctctc tgagggcatt      900

cgcgagtggt gggacttgaa acctggagcc ccgaaaccca aagccaacca gcaaaagcag      960

gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt caacggactc     1020

gacaagggag agccggtcaa cgcggcggac gcagcggccc tcgagcacga caaggcctac     1080

gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc cgacgccgag     1140

tttcaggagc gtcttcaaga agatacgtct tttgggggca acctcgggcg agcagtcttc     1200

caggccaaga agcgggttct cgaacctctc ggtctggttg aggaaggcgc taagacggct     1260

cctggaaaga agagacccat agaatccccc gactcctcca cgggcatcgg caagaaaggc     1320

cagcagcccg ctaaaaagaa gctcaacttt gggcagactg gcgactcaga gtcagtgccc     1380

gaccctcaac caatcggaga accccccgca ggcccctctg gtctgggatc tggtacaatg     1440

gctgcaggcg gtggcgctcc aatggcagac aataacgaag gcgccgacgg agtgggtaat     1500

gcctccggaa attggcattg cgattccaca tggctgggcg acagagtcat caccaccagc     1560

acccgcacct gggccctgcc cacctacaac aaccacctct acaagcagat atcaagtcag     1620

agcggggcta ccaacgacaa ccacttcttc ggctacagca ccccctgggg ctattttgac     1680

ttcaacagat tccactgcca cttctcacca cgtgactggc agcgactcat caacaacaac     1740

tggggattcc ggcccagaaa gctgcggttc aagttgttca acatccaggt caaggaggtc     1800

acgacgaacg acggcgttac gaccatcgct aataacctta ccagcacgat tcaggtcttc     1860

tcggactcgg agtaccaact gccgtacgtc ctcggctctg cgcaccaggg ctgcctccct     1920

ccgttccctg cggacgtgtt catgattcct cagtacggat atctgactct aaacaacggc     1980

agtcagtctg tgggacgttc ctccttctac tgcctggagt actttccttc tcagatgctg     2040

agaacgggca ataactttga attcagctac acctttgagg aagtgccttt ccacagcagc     2100

tatgcgcaca gccagagcct ggaccggctg atgaatcccc tcatcgacca gtacctgtac     2160

tacctggccc ggacccagag cactacgggg tccacaaggg agctgcagtt ccatcaggct     2220

gggcccaaca ccatggccga gcaatcaaag aactggctgc ccggaccctg ttatcggcgg     2280

cagagactgt caaaagacat agacagcaac aacaacagta actttgcctg gaccggggcc     2340

actaaatacc atctgaatgg tagaaattca ttaaccaacc cgggcgtagc catggccacc     2400

aacaaggacg acgaggacca gttctttccc atcaacggag tgctggtttt tggcaaaacg     2460

ggggctgcca acaagacaac gctggaaaac gtgctaatga ccagcgagga ggagatcaaa     2520

accaccaatc ccgtggctac agaagaatac ggtgtggtct ccagcaacct gcaatcgtct     2580

acggccggac cccagacaca gactgtcaac agccaggggg ctctgcccgg catggtctgg     2640

cagaaccggg acgtgtacct gcagggtccc atctgggcca aaattcctca cacggacggc     2700

aactttcacc cgtctcccct gatgggcgga tttggactca aacacccgcc tcctcaaatt     2760

ctcatcaaaa acaccccggt acctgctaat cctccagagg tgtttactcc tgccaagttt     2820

gcctcattta tcacgcagta cagcaccggc caggtcagcg tggagatcga gtgggaactg     2880

cagaaagaga acagcaaacg ctggaatcca gagattcagt acacctcaaa ttatgccaag     2940

tctaataatg tggaatttgc tgtcaacaac gaaggggttt atactgagcc tcgccccatt     3000

ggcacccgtt acctcacccg taacctgtaa ttacttgtta atcaataaac cggttgattc     3060

gtttcagttg aactttggtc tctgcgaagg gcgaattc                             3098


<210> 5006
<211> 2969
<212> DNA
<213> Adeno-associated virus

<400> 5006
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaagg tgcgcgtgga ccaaaagtgc aagtcgtccg      180

cccagatcga ccccaccccc gtgatcgtca cctccaacac caacatgtgc gccgtgattg      240

acgggaacag caccaccttc gagcaccagc agccgttaca agaccggatg ttcaaatttg      300

aactcacccg ccgtctggag cacgactttg gcaaggtgac aaagcaggaa gtcaaagagt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca tgagttctac gtcagaaagg      420

gtggagccaa caagagaccc gcccccgatg acgcggataa aagcgagccc aagcgggcct      480

gcccctcagt cgcggatcca tcgacgtcag acgcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg tttccctgca      600

agacatgcga gagaatgaat cagaatttca acatttgctt cacgcacggg accagagact      660

gttcagaatg tttccccggc gtgtcagaat ctcaaccggt cgtcagaaag aggacgtatc      720

ggaaactctg tgccattcat catctgctgg ggcgggctcc cgagattgct tgctcggcct      780

gcgatctggt caacgtggac ctggatgact gtgtttctga gcaataaatg acttaaacca      840

ggtatggctg ccgatggtta tcttccagat tggctcgagg acaacctctc tgagggcatc      900

cgcgagtggt gggacttgaa acctggagcc ccgaaaccca aagccaacca gcaaaagcag      960

gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt caacggactc     1020

gacaagggag agccggtcaa cgaggcagac gccgcggccc tcgagcacga caaggcctac     1080

gacaagcagc tcgagcaggg ggacaacccg tacctcaagt acaaccacgc cgacgccgag     1140

tttcaggagc gtcttcaaga agatacgtct tttgggggca acctcgggcg agcagtcttc     1200

caggccaaga agcgggttct cgaacctctc ggtctggttg aggaaggcgc taagacggct     1260

cctggaaaga agagaccggt agagccatca ccccagcgtt ctccagactc ctctacgggc     1320

atcggcaaga caggccagca gcccgcgaaa aagagactca actttgggca gactggcgac     1380

tcagagtcag tgcccgaccc tcaaccaatc ggagaacccc ccgcaggccc ctctggtctg     1440

ggatctggta caatggctgc aggcggtggc gctccaatgg cagacaataa cgaaggcgcc     1500

gacggagtgg gtagttcctc aggaaattgg cattgcgatt ccacatggct gggcgacaga     1560

gtcatcacca ccagcacccg aacctgggcc ctccccacct acaacaacca cctctacaag     1620

caaatctcca acgggacatc gggaggaagc accaacgaca acacctactt cggctacagc     1680

accccctggg ggtattttga ctttaacaga ttccactgcc acttctcacc acgtgactgg     1740

cagcgactca tcaacaacaa ctggggattc cggcccaaga gactcaactt caagctcttc     1800

aacatccagg tcaaggaggt cacgcagaat gaaggcacca agaccatcgc caataacctt     1860

accagcacga ttcaggtctt tacggactcg gaataccagc tcccgtacgt cctcggctct     1920

gcgcaccagg gctgcctgcc tccgttcccg gcggacgtct tcatgattcc tcagtacggg     1980

tacctgactc tgaacaacgg cagtcaggcc gtgggccgtt cctccttcta ctgcctggag     2040

tactttcctt ctcaaatgct gagaacgggc aacaactttg agttcagcta ccagtttgag     2100

gacgtgcctt ttcacagcag ctacgcgcac agccaaagcc tggaccggct gacgaacccc     2160

ctcatcgacc agtacctgta ctacctggcc cggacccaga gcactacggg gtccacaagg     2220

gggctgcagt tccatcaggc tgggcccaac accatggccg agcaatcaaa gaactggctg     2280

cccggaccct gttatcggca gcagagactg tcaaaaaaca tagacagcaa caacaacagt     2340

aactttgcct ggaccggggc cactaaatac catctgaatg gtagaaattc attaaccaac     2400

ccgggcgtag ccatggccac caacaaggac gacgaggacc agttctttcc catcaacgga     2460

gtgctggttt ttggcaaaac gggggctgcc aacaagacaa cgctggaaaa cgtgctaatg     2520

accagcgagg aggagatcaa aaccaccaat cccgtggcta cagaagaata cggtgtggtc     2580

tccagcaacc tgcaatcgtc tacggccgga ccccagacac agactgtcaa cagccagggg     2640

gctctgcccg gcatggtctg gcagaaccgg gacgtgtacc tgcagggtcc catctgggcc     2700

aaaattcctc acacggacgg caactttcac ccgtctcccc tgatgggcgg atttggactc     2760

aaacacccgc ctcctcaaat tctcatcaag tatacttcca actactacaa atctacaaat     2820

gtggactttg ctgtcaatac tgagggtact tattcagagc ctcgccccat tggcacccgt     2880

tacctcaccc gtaacctgta attgcctgtt aatcaataaa ccggttaatt cgtttcagtt     2940

gaactttggt ctctgcgaag ggcgaattc                                       2969


<210> 5007
<211> 3113
<212> DNA
<213> Adeno-associated virus

<400> 5007
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaagg tgcgcgtgga ccaaaagtgc aagtcgtccg      180

cccagatcga tcccaccccc gtgatcgtca cttccaacac caacatgtgc gccgtgattg      240

acgggaacag caccaccttc gagcaccagc agccgttaca agaccggatg ttcaaatttg      300

aactcacccg ccgtctggag catgactttg gcaaggtgac aaagcaggaa gtcaaagagt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca tgagttctac gtcagaaagg      420

gtggagccaa caagagaccc gcccccgatg acgcggataa aagcgagccc aagcgggcct      480

gcccctcagt cgcggatcca tcgacgtcag acgcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg tttccctgca      600

agacatgcga gagaatgaat cagaatttca acatttgctt cacgcacggg accagagact      660

gttcagaatg tttccccggc gtgtcagaat ctcaaccggt cgtcagaaag aggacgtatc      720

ggaaactctg tgccattcat catctgctgg ggcgggctcc cgagattgct tgctcggcct      780

gcgatctggt caacgtggac ctggatgact gtgtttctga gcaataaatg acttaaacca      840

ggtatggctg ccgatggtta tcttccagat tggctcgagg acaacctctc tgagggcatt      900

cgcgagtggt gggacttgaa acctggagcc ccgaaaccca aagccaacca gcaaaagcag      960

gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt caacggactc     1020

gacaaggggg agcccgtcaa cgcggcggac gcagcggccc tcgagcacga caaggcctac     1080

gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc cgacgccgag     1140

tttcaggagc gtcttcaaga agatacgtct tttgggggca acctcgggcg agcagtcttc     1200

caggccaaga agcgggttct cgaacctctc ggtctggttg aggaaggcgc taagacggct     1260

cctggaaaga agagacccat agaatccccc gactcctcca cgggcatcgg caagaaaggc     1320

cagcagcccg ctaaaaagaa gctcaacttt gggcagactg gcgactcaga gtcagtgccc     1380

gaccctcaac caatcggaga accccccgca ggcccctctg gtctgggatc tggtacaatg     1440

gctgcaggcg gtggcgctcc aatggcagac aataacgaag gcgccgacgg agtgggtagt     1500

tcctcaggaa attggcattg cgattccaca tggctgggcg acagagtcat caccaccagc     1560

acccgaacct gggccctccc cacctacaac aaccacctct acaagcaaat ctccaacggg     1620

acatcgggag gaagcaccaa cgacaacacc tacttcggct acagcacccc ctgggggtat     1680

tttgacttta acagattcca ctgccacttc tcaccacgtg actggcagcg actcatcaac     1740

aacaactggg gattccggcc caagagactc aacttcaagc tcttcaacat ccaggtcaag     1800

gaggtcacgc agaatgaagg caccaagacc atcgccaata accttaccag cacgattcag     1860

gtctttacgg actcggaata ccagctcccg tacgtcctcg gctctgcgca ccagggctgc     1920

ctgcctccgt tcccggcgga cgtcttcatg attcctcagt acgggtacct gactctgaac     1980

aacggcagtc aggccgtggg ccgttcctcc ttctactgcc tggagtactt tccttctcaa     2040

atgctgagaa cgggcaacaa ctttgagttc agctaccagt ttgaggacgt gccttttcac     2100

agcagctatg cgcacagcca aagcctggac cggctgatga accccctcat cgaccagtac     2160

ctgtactacc tgtctcggac tcagtccacg ggaggtaccg caggaactca gcagttgcta     2220

ttttctcagg ccgggcctaa taacatgtcg gctcaggcca aaaactggct acccgggccc     2280

tgctaccggc agcaacgcgt ctccacgaca gtgtcgcaaa ataacaacag caactttgct     2340

tggaccggtg ccaccaagta tcatctgaat ggcagagact ctctggtaaa tcccggtgtc     2400

gctatggcaa cgcacaaggg cgacgaagag cgattttttc catccagcgg agtcttgatg     2460

tttgggaaac agggagctgg aaaagacaac gtggactata gcagcgttat gctaaccagt     2520

gaggaagaaa tcaaaaccac caacccagtg gccacagaac agtacggcgt ggtggccgat     2580

aacctgcaac agcaaaacgc cgctcctatt gtaggggccg tcaacagtca aggagcctta     2640

cctggcatgg tctggcagaa ccgggacgtg tacctgcagg gtcctatctg ggccaagatt     2700

cctcacacgg acggcaactt tcatccttcg ccgctgatgg gaggctttgg actgaaacac     2760

ccgcctcctc agatcctgat taagaataca cctgttcccg cggatcctcc aactaccttc     2820

agtcaagcca agctggcgtc gttcatcacg cagtacagca ccggacaggt cagcgtggaa     2880

attgaatggg agctgcagaa agagaacagc aagcgctgga acccagagat tcagtatact     2940

tccaactact acaaatctac aaatgtggac tttgctgtca atactgaggg tacttattca     3000

gagcctcgcc ccattggcac ccgttacctc acccgtagcc tgtaattgcc tgttaatcaa     3060

taaaccggtt gattcgtttc agttgaactt tggtctctgc gaagggcgaa ttc            3113


<210> 5008
<211> 3128
<212> DNA
<213> Adeno-associated virus

<400> 5008
gaattcgccc tttctacggc tgcgtcaact ggaccaatga gaactttccc ttcaacgatt       60

gcgtcgacaa gatggtgatc tggtgggagg agggcaagat gacggccaag gtcgtggagt      120

ccgccaaggc cattctcggc ggcagcaagg tgcgcgtgga ccaaaagtgc aagtcgtccg      180

cccagatcga ccccaccccc gtgatcgtca cctccaacac caacatgtgc gccgtgattg      240

acgggaacag caccaccttc gagcaccagc agccgttgca ggaccggatg ttcaaatttg      300

aactcacccg ccgtctggag catgactttg gcaaggtgac aaagcaggaa gtcaaagagt      360

tcttccgctg ggcgcaggat cacgtgaccg aggtggcgca tgagttctac gtcagaaagg      420

gtggagccaa caagagaccc gcccccgatg acgcggataa aagcgagccc aagcgggcct      480

gcccctcagt cgcggatcca tcgacgtcag acgcggaagg agctccggtg gactttgccg      540

acaggtacca aaacaaatgt tctcgtcacg cgggcatgct tcagatgctg tttccctgca      600

agacatgcga gagaatgaat cagaatttca acatttgctt cacgcgcggg accagagact      660

gttcagaatg tttcccgggc gtgtcagaat ctcaaccggt cgtcagaaag aggacgtatc      720

ggaaactctg tgccattcat catctgctgg ggcgggctcc cgagattgct tgctcggcct      780

gcgatctggt caacgtggac ctggatgact gtgtttctga gcaataaatg acttaaacca      840

ggtatggctg ccgatggtta tcttccagat tggctcgagg acaacctctc tgagggcatt      900

cgcgagtggt gggacttgaa acctggagcc ccgaaaccca aagccaacca gcaaaagcag      960

gacgacggcc ggggtctggt gcttcctggc tacaagtacc tcggaccctt caacggactc     1020

gacaaggggg agcccgtcaa cgcggcggac gcagcggccc tcgagcacga caaggcctac     1080

gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc cgacgccgag     1140

tttcaggagc gtctgcaaga agatacgtct tttgggggca acctcgggcg agcagtcttc     1200

caggccaaga agcgggttct cgaacctctc ggtctggttg aggaaggcgc taagacggct     1260

cctggaaaga agagaccggt agagccatca ccccagcgtt ctccagactc ctctacgggc     1320

atcggcaaga caggccagca gcccgcgaaa aagagactca actttgggca gactggcgac     1380

tcagagtcag tgcccgaccc tcaaccaatc ggagaacccc ccgcaggccc ctctggtctg     1440

ggatctggta caatggctgc aggcggtggc gctccaatgg cagacaataa cgaaggcgcc     1500

gacggagtgg gtagttcctc aggaaattgg cattgcgatt ccacatggct gggcgacaga     1560

gtcatcacca ccagcacccg aacctgggcc ctccccacct acaacaacca cctctacaag     1620

caaatctcca acgggacatc gggaggaagc accaacgaca acacctactt cggctacagc     1680

accccctggg ggtattttga ctttaacaga ttccactgcc acttctcacc acgtgactgg     1740

cagcgactca tcaacaacaa ctggggattc cggcccaaga gactcaactt caagctcttc     1800

aacatccagg tcaaggaggt cacgcagaat gaaggcacca agaccatcgc caataacctt     1860

accagcacga ttcaggtctt tacggactcg gaataccagc tcccgtacgt cctcggctct     1920

gcgcaccagg gctgcccgcc tccgttcccg gcggacgtct tcatgattcc tcagtacggg     1980

tacctgactc tgaacaacgg cagtcaggcc gtgggccgtt cctccttcta ctgcctggag     2040

tactttcctt ctcaaatgcg gagaacgggc aacaactttg agttcagcta ccagtttgag     2100

gacgtgcctt ttcacagcag ctacgcgcat agccaaagcc tggaccggct gatgaacccc     2160

ctcatcgacc agtacctgta ctacctgtct cggactcagt ccacgggagg taccgcagga     2220

actcagcagt tgctattttc tcaggccggg cctaataaca tgtcggctca ggccaaaaac     2280

tggctacccg ggccctgcta ccggcagcaa cgcgtctcca cgacactgtc gcaaaataac     2340

aacagcaact ttgcttggac cggtgccacc aagtatcatc tgaatggcag agactctctg     2400

gtaaatcccg gtgtcgctat ggcaacgcac aaggacgacg aagagcgatt ttttccatcc     2460

agcggagtct tgatgtttgg gaaacaggga gctggaaaag acaacgtgga ctatagcagc     2520

gttatgctaa ccagtgagga agaaatcaaa accaccaacc cagtggccac agaacagtac     2580

ggcgtggtgg ccgataacct gcaacagcaa aacgccgctc ctattgtagg ggccgtcaac     2640

agtcaaggag ccttacctgg catggtctgg cagaaccggg acgtgtacct gcagggtcct     2700

atctgggcca agattcctca cacggacggc aactttcatc cttcgccgct gatgggaggc     2760

tttggactga aacacccgcc tcctcagatc ctgattaaga atacacctgt tcccgcggat     2820

cctccaacta ccttcagtca agccaagctg gcgtcgttca tcacgcagta cagcaccgga     2880

caggtcagcg tggaaattga atgggagctg cagaaagaga acagcaagcg ctggaaccca     2940

gagattcagt atacttccaa ctactacaaa tctacaaatg tggactttgc tgtcaatact     3000

gagggtactt attcagagcc tcgccccatt ggcacccgtt acctcacccg taacctgtaa     3060

ttgcctgtta atcaataaac cggttaattc gtttcagttg aactttggtc tctgcgaagg     3120

gcgaattc                                                              3128


<210> 5009
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5009
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly His Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Pro Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Gly Ala 
            580                 585                 590         


Pro Ile Val Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5010
<211> 1933
<212> DNA
<213> Adeno-associated virus


<220>
<221> modified_base
<222> (1302)..(1302)
<223> a, c, t or g

<400> 5010
caaggcctac gaccagcagc tcaaagcggg tgacaatccg tacctgcggt ataaccacgc       60

cgacgccgag tttcaggagc gtcttcaaga agatacgtct tttgggggca acctcgggcg      120

agcagtcttc caggccaaaa agcgggttct cgaacctctt ggtctggttg agacgccagc      180

taagacggca cctggaaaga agcgaccggt agactcgcca gactccacct cgggcatcgg      240

caagaaaggc cagcagcccg cgaaaaagag actcaacttt gggcagactg gcgactcaga      300

gtcagtcccc gaccctcaac caatcggaga accaccagca ggcccctctg gtctgggatc      360

tggtacaatg gctgcaggcg gtggcgcacc aatggctgac aataacgagg gcgccgacgg      420

agtgggtaat gcctcaggaa attggcattg cgattccaca tggctgggcg acagagtcat      480

caccaccagc acccgaacct gggccctgcc cacctacaac aaccacctct acaagcaaat      540

ctccagtcag tcagcaggga gcaccaacga taacgtctat ttcggctaca gcaccccctg      600

ggggtatttt gacttcaaca gattccattg ccacttctca ccacgtgact ggcagcgact      660

tatcaacaac aactggggat tccggcccaa gaagctcaac ttcaagctct tcaacatcca      720

ggtcaaggag gtcacgacga atgacggtgt cacaaccatc gctaataacc ttaccagcac      780

ggttcaggtc ttttcggact cggaatatca actgccgtac gtcctcggct ccgcgcacca      840

gggctgcctg cctccgttcc cggcagacgt gttcatgatt ccgcagtacg gatacctgac      900

tctgaacaat ggcagccaat cggtaggccg ttcctccttc tactgcctgg agtactttcc      960

ttctcagatg ctgagaacgg gcaacaactt cacctttagc tacaccttcg aggacgtgcc     1020

tttccacagc agctacgcgc acagccagag tctggaccgg ctgatgaatc ccctcatcga     1080

ccagtacctg tactacttgg ccagaacaca gagcaacgca ggaggtactg ctggcaatcg     1140

ggaactgcag ttttatcagg gcggacctac caccatggcc gaacaagcaa agaactggct     1200

gcccggacct tgcttccggc aacagagagt atccaagacg ctggatcaaa ataacaacag     1260

caactttgcc tggactggtg ccacaaaata ccatttaaat gnaagaaatt cattggttaa     1320

tcccggtgtc gccatggcaa cccacaagga cgacgaggaa cgcttcttcc cttcgagcgg     1380

agttctaatt tttggcaaaa ctggagcagc taataaaact acattagaaa acgtgctcat     1440

gacaaatgaa gaagaaattc gtcctaccaa cccggtagct accgaggaat acgggattgt     1500

aagcagcaac ttgcaggcgg ctagcaccgc agcccagaca caagttgtta acaaccaggg     1560

agccttacct ggcatggtct ggcagaaccg ggacgtgtac ctgcaaggtc ccatttgggc     1620

caagattcct cacacggacg gcaactttca cccgtctcct ctaatgggtg gctttggact     1680

gaaacacccg cctccccaga tcctgatcaa aaacacaccg gtacctgcta atcctccaga     1740

agtgtttact cctgccaagt ttgcttcctt catcacgcag tacagcaccg ggcaagtcag     1800

cgttgagatc gagtgggagc tgcagaaaga gaacagcaag cgctggaacc cagagattca     1860

gtacacctcc aactttgaca aacagactgg agtggacttt gctgttgaca gccagggtgt     1920

ttactctgag cct                                                        1933


<210> 5011
<211> 3105
<212> DNA
<213> Adeno-associated virus

<400> 5011
gaattcgccc ttgctgcgtc aactggacca atgagaactt tcccttcaac gattgcgtcg       60

acaagatggt gatctggtgg gaggagggca agatgaccgc caaggtcgtg gagtccgcca      120

aggccattct gggcggaagc aaggtgcgcg tggaccaaaa gtgcaagtca tcggcccaga      180

tcgaccccac gcccgtgatc gtcacctcca acaccaacat gtgcgccgtg atcgacggga      240

acagcaccac cttcgagcac cagcagccgc tgcaggaccg catgttcaag ttcgagctca      300

cccgccgtct ggagcacgac tttggcaagg tgaccaagca ggaagtcaaa gagttcttcc      360

gctgggctca ggatcacgtg actgaggtgg cgcatgagtt ctacgtcaga aagggcggag      420

ccaccaaaag acccgccccc agtgacgcgg atataagcga gcccaagcgg gcctgcccct      480

cagttgcgga gccatcgacg tcagacgcgg aagcaccggt ggactttgcg gacaggtacc      540

aaaacaaatg ttctcgtcac gcgggcatgc ttcagatgct gtttccctgc aagacatgcg      600

agagaatgaa tcagaatttc aacgtctgct tcacgcacgg ggtcagagac tgctcagagt      660

gcttccccgg cgcgtcagaa tctcaacccg tcgtcagaaa aaagacgtat cagaaactgt      720

gcgcgattca tcatctgctg gggcgggcac ccgagattgc gtgttcggcc cgcgatctcg      780

tcaacgtgga cttggatgac tgtgtttctg agcaataaat gacttaaacc aggtatggct      840

gctgacggtt atcttccaga ttggctcgag gacaacctct ctgagggcat tcgcgagtgg      900

tgggacctga aacctggagc ccccaagccc aaggccaacc agcagaagca ggacgacggc      960

cggggtctgg tgcttcctgg ctacaagtac ctcggaccct tcaacggact cgacaagggg     1020

gagcccgtca acgcggcgga cgcagcggcc ctcgagcacg acaaggccta cgaccagcag     1080

ctcaaagcgg gtgacaatcc gtacctgcgg tataaccacg ccgacgccga gtttcaggag     1140

cgtctgcaag aagatacgtc ttttgggggc aacctcgggc gagcagtctt ccaggccaag     1200

aagagggtac tcgaacctct gggcctggtt gaagaaggtg ctaagacggc tcctggaaag     1260

aagagaccgt tagagtcacc acaagagccc gactcctcct caggaatcgg caaaaaaggc     1320

aaacaaccag ccaaaaagag actcaacttt gaagaggaca ctggagccgg agacggaccc     1380

cctgaaggat cagataccag cgccatgtct tcagacattg aaatgcgtgc agcaccgggc     1440

ggaaatgctg tcgatgcggg acaaggttcc gatggagtgg gtaatgcctc gggtgattgg     1500

cattgcgatt ccacctggtc tgagggcaag gtcacaacaa cctcgaccag aacctgggtc     1560

ttgcccacct acaacaacca cttgtacctg cggctcggaa caacatcaaa cagcaacacc     1620

tacaacggat tctccacccc ctggggatac tttgacttta acagattcca ctgtcacttc     1680

tcaccacgtg actggcaaag actcatcaac aacaactggg gactacgacc aaaagccatg     1740

cgcgttaaaa tcttcaatat ccaagttaag gaggtcacaa cgtcgaacgg cgagactacg     1800

gtcgctaata accttaccag cacggttcag atatttgcgg actcgtcgta tgagctcccg     1860

tacgtgatgg acgctggaca agagggaagt ctgtctcctt tccccaatga cgtcttcatg     1920

gtgcctcaat atggctactg tggcattgtg actggcgaaa atcagaacca gacggacaga     1980

aatgctttct actgcctgga gtattttcct tcacaaatgc tgagaactgg caataacttt     2040

gaaatggctt acaactttgg gaaggtgccg ttccactcaa tgtatgctta cagccagagc     2100

ccggacagac tgatgaatcc cctcctggac cagtacctgt ggcacttaca gtcgaccacc     2160

tctggagaga ctctgaatca aggcaatgca gcaaccacat ttggaaaaat caggagtgga     2220

gactttgcct tttacagaaa gaactggctg cctgggcctt gtgttaaaca gcagagactc     2280

tcaaaaactg ccagtcaaaa ttacaagatt cctgccagcg ggggcaacgc tctgttaaag     2340

tatgacaccc actatacctt aaacaaccgc tggagcaaca tagcgcctgg acctccaatg     2400

gcaacagctg gaccttcaga tggggacttc agcaacgccc agctcatctt ccctggacca     2460

tcagtcaccg gaaacacaac aacctcagca aacaatctgt tgtttacatc agaagaagaa     2520

attgctgcca ccaacccaag agacacggac atgtttggtc agattgctga caataatcag     2580

aatgctacaa ctgctcccat aaccggcaac gtgactgcta tgggagtgct tcctggcatg     2640

gtgtggcaaa acagagacat ttactaccaa gggccaattt gggccaagat cccacacgcg     2700

gacggacatt ttcatccttc accgctaatt ggcggttttg gactgaaaca tccgcctccc     2760

cagatattta tcaaaaacac ccccgtacct gccaatcctg cgacaacctt cactgcagcc     2820

agagtggact ctttcatcac acaatacagc accggccagg tcgctgttca gattgaatgg     2880

gaaatcgaaa aggaacgctc caaacgctgg aatcctgaag tgcagtttac ttcaaactat     2940

gggaaccagt cttctatgtt gtgggctccc gatacaactg ggaagtatac agagccgcgg     3000

gttattggct ctcgttattt gactaatcat ttgtaactgc ctagttaatc aataaaccgt     3060

gtgattcgtt tcagttgaac tttggtctct gcgaagggcg aattc                     3105


<210> 5012
<211> 733
<212> PRT
<213> Adeno-associated virus

<400> 5012
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Leu Glu Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly Lys 
145                 150                 155                 160 


Lys Gly Lys Gln Pro Ala Lys Lys Arg Leu Asn Phe Glu Glu Asp Thr 
                165                 170                 175     


Gly Ala Gly Asp Gly Pro Pro Glu Gly Ser Asp Thr Ser Ala Met Ser 
            180                 185                 190         


Ser Asp Ile Glu Met Arg Ala Ala Pro Gly Gly Asn Ala Val Asp Ala 
        195                 200                 205             


Gly Gln Gly Ser Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys 
    210                 215                 220                 


Asp Ser Thr Trp Ser Glu Gly Lys Val Thr Thr Thr Ser Thr Arg Thr 
225                 230                 235                 240 


Trp Val Leu Pro Thr Tyr Asn Asn His Leu Tyr Leu Arg Leu Gly Thr 
                245                 250                 255     


Thr Ser Asn Ser Asn Thr Tyr Asn Gly Phe Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Asn Trp Gly Leu Arg Pro Lys Ala Met Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Thr Ser Asn Gly Glu 
305                 310                 315                 320 


Thr Thr Val Ala Asn Asn Leu Thr Ser Thr Val Gln Ile Phe Ala Asp 
                325                 330                 335     


Ser Ser Tyr Glu Leu Pro Tyr Val Met Asp Ala Gly Gln Glu Gly Ser 
            340                 345                 350         


Leu Pro Pro Phe Pro Asn Asp Val Phe Met Val Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Cys Gly Ile Val Thr Gly Glu Asn Gln Asn Gln Thr Asp Arg Asn Ala 
    370                 375                 380                 


Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Glu Met Ala Tyr Asn Phe Glu Lys Val Pro Phe His Ser Met 
                405                 410                 415     


Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Leu Asp 
            420                 425                 430         


Gln Tyr Leu Trp His Leu Gln Ser Thr Thr Ser Gly Glu Thr Leu Asn 
        435                 440                 445             


Gln Gly Asn Ala Ala Thr Thr Phe Gly Lys Ile Arg Ser Gly Asp Phe 
    450                 455                 460                 


Ala Phe Tyr Arg Lys Asn Trp Leu Pro Gly Pro Cys Val Lys Gln Gln 
465                 470                 475                 480 


Arg Phe Ser Lys Thr Ala Ser Gln Asn Tyr Lys Ile Pro Ala Ser Gly 
                485                 490                 495     


Gly Asn Ala Leu Leu Lys Tyr Asp Thr His Tyr Thr Leu Asn Asn Arg 
            500                 505                 510         


Trp Ser Asn Ile Ala Pro Gly Pro Pro Met Ala Thr Ala Gly Pro Ser 
        515                 520                 525             


Asp Gly Asp Phe Ser Asn Ala Gln Leu Ile Phe Pro Gly Pro Ser Val 
    530                 535                 540                 


Thr Gly Asn Thr Thr Thr Ser Ala Asn Asn Leu Leu Phe Thr Ser Glu 
545                 550                 555                 560 


Glu Glu Ile Ala Ala Thr Asn Pro Arg Asp Thr Asp Met Phe Gly Gln 
                565                 570                 575     


Ile Ala Asp Asn Asn Gln Asn Ala Thr Thr Ala Pro Ile Thr Gly Asn 
            580                 585                 590         


Val Thr Ala Met Gly Val Leu Pro Gly Met Val Trp Gln Asn Arg Asp 
        595                 600                 605             


Ile Tyr Tyr Gln Gly Pro Ile Trp Ala Lys Ile Pro His Ala Asp Gly 
    610                 615                 620                 


His Phe His Pro Ser Pro Leu Ile Gly Gly Phe Gly Leu Lys His Pro 
625                 630                 635                 640 


Pro Pro Gln Ile Phe Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Ala 
                645                 650                 655     


Thr Thr Phe Thr Ala Ala Arg Val Asp Ser Phe Ile Thr Gln Tyr Ser 
            660                 665                 670         


Thr Gly Gln Val Ala Val Gln Ile Glu Trp Glu Ile Glu Lys Glu Arg 
        675                 680                 685             


Ser Lys Arg Trp Asn Pro Glu Val Gln Phe Thr Ser Asn Tyr Gly Asn 
    690                 695                 700                 


Gln Ser Ser Met Leu Trp Ala Pro Asp Thr Thr Gly Lys Tyr Thr Glu 
705                 710                 715                 720 


Pro Arg Val Ile Gly Ser Arg Tyr Leu Thr Asn His Leu 
                725                 730             


<210> 5013
<211> 3105
<212> DNA
<213> Adeno-associated virus

<400> 5013
gaattcgccc ttgctgcgtc aactggacca atgagaactt tcccttcaac gattgcgtcg       60

acaagatggt gatctggtgg gaggagggca agatgaccgc caaggtcgtg gagtccgcca      120

aggccattct gggcggaagc aaggtgcgcg tggaccaaaa gtgcaagtca tcggcccaga      180

tcgaccccac gcccgtgatc gtcacctcca acaccaacat gtgcgccgtg atcgacggga      240

acagcaccac cttcgagcac cagcagccgc tgcaggaccg catgttcaag ttcgagctca      300

cccgccgtct ggagcacgac tttggcaagg tgaccaagca ggaagtcaaa gagttcttcc      360

gctgggctca ggatcacgtg actgaggtgg cgcatgagtt ctacgtcaga aagggcggag      420

ccaccaaaag acccgccccc agtgacgcgg atataagcga gcccaagcgg gcctgcccct      480

cagttgcgga gccatcgacg tcagacgcgg aagcaccggt ggactttgcg gacaggtacc      540

aaaacaaatg ttctcgtcac gcgggcatgc ttcagatgct gtttccctgc aagacatgcg      600

agagaatgaa tcagaatttc aacgtctgct tcacgcacgg ggtcagagac tgctcagagt      660

gcttccccgg cgcgtcagaa tctcaacccg tcgtcagaaa aaagacgtat cagaaactgt      720

gcgcgattca tcatctgctg gggcgggcac ccgagattgc gtgttcggcc tgcgatctcg      780

tcaacgtgga cttggatgac tgtgtttctg agcaataaat gacttaaacc aggtatggct      840

gctgacggtt atcttccaga ttggctcgag gacaacctct ctgagggcat tcgcgagtgg      900

tgggacctga aacctggagc ccccaagctc aaggccaacc agcagaagca ggacgacggc      960

cggggtctgg tgcttcctgg ctacaagtac ctcggaccct tccacggact cgacaagggg     1020

gagcccgtca acgcggcgga cgcagcggcc ctcgagcacg acaaggccta cgaccagcag     1080

ctcaaagcgg gtgacaatcc gtacctgcgg tataaccacg ccgacgccga gtttcaggag     1140

cgtctgcaag aagatacgtc ttttgggggc aacctcgggc gagcagtctt ccaggccaag     1200

aagagggtac tcgaaccact gggcctggtt gaagaaggtg ctaagacggc tcctggaaag     1260

aagagaccgt tagagtcacc acaagagccc gactcctcct caggaatcgg caaaaaaggc     1320

aaacaaccag ccaaaaagag actcaacttt gaagaggaca ctggagccgg agacggaccc     1380

cctgaaggat cagataccag cgccatgtct tcagacattg aaatgcgtgc agcaccgggc     1440

ggaaatgctg tcgatgcggg acaaggttcc gatggagtgg gtaatgcctc gggtgattgg     1500

cattgcgatt ccacctggtc tgagggcaag gtcacaacaa cctcgaccag aacctgggtc     1560

ttgcccacct acaacaacca cttgtacctg cggctcggaa caacatcaaa cagcaacacc     1620

tacaacggat tctccacccc ctggggatac tttgacttta acagattcca ctgtcacttc     1680

tcaccacgtg actggcaaag actcatcaac aacaactggg gactacgacc aaaagccatg     1740

cgcgttaaaa tcttcaatat ccaagttaag gaggtcacaa cgtcgaacgg cgagactacg     1800

gtcgctaata accttaccag cacggttcag atatttgcgg actcgtcgta tgagctcccg     1860

tacgtgatgg acgctggaca agagggaagt ctgcctcctt tccccaatga cgtcttcatg     1920

gtgcctcaat atggctactg tggcattgtg actggcgaaa atcagaacca gacggacaga     1980

aatgctttct actgcctgga gtattttcct tcacaaatgc tgagaactgg caataacttt     2040

gaaatggctt acaactttga gaaggtgccg ttccactcaa tgtatgctca cagccagagc     2100

ctggacagac tgatgaatcc cctcctggac cagtacctgt ggcacttaca gtcgaccacc     2160

tctggagaga ctctgaatca aggcaatgca gcaaccacat ttggaaaaat caggagtgga     2220

gactttgcct tttacagaaa gaactggctg cctgggcctt gtgttaaaca gcagagattc     2280

tcaaaaactg ccagtcaaaa ttacaagatt cctgccagcg ggggcaacgc tctgttaaag     2340

tatgacaccc actatacctt aaacaaccgc tggagcaaca tagcgcctgg acctccaatg     2400

gcaacagctg gaccttcaga tggggacttc agcaacgccc agctcatctt ccctggacca     2460

tcagtcaccg gaaacacaac aacctcagca aacaatctgt tgtttacatc agaaggagaa     2520

attgctgcca ccaacccaag agacacggac atgtttggtc agattgctga caataatcag     2580

aatgctacaa ctgctcccat aaccggcaac gtgactgcta tgggagtgct tcctggcatg     2640

gtgtggcaaa acagagacat ttactaccaa gggccaattt gggccaagat cccacacgcg     2700

gacggacatt ttcatccttc accgctaatt ggcggttttg gactgaaaca tccgcctccc     2760

cagatattta tcaaaaacac ccccgtacct gccaatcctg cgacaacctt cactgcagcc     2820

agagtggact ctttcatcac acaatacagc accggccagg tcgctgttca gattgaatgg     2880

gaaatcgaaa aggaacgctc caaacgccgg aatcctgaag tgcagtttac ttcaaactat     2940

gggaaccagt cttctatgtt gtgggctccc gatacaactg ggaagtatac agagccgcgg     3000

gttattggct ctcgttattt gactaatcat ttgtaactgc ctagttaatc aataaaccgt     3060

gtgattcgtt tcagttgaac tttggtctct gcgaagggcg aattc                     3105


<210> 5014
<211> 3105
<212> DNA
<213> Adeno-associated virus

<400> 5014
gaattcgccc ttcgcagaga ccaaagttca actgaaacga atcacacggt ttattgatta       60

actaggcagt tacaaatgat tagtcaaata acgagagcca ataacccgcg gctctgtata      120

cttcccagtt gtatcgggag cccacaacat agaagactgg ttcccacagt ttgaagtaaa      180

ctgcacttca ggattccagc gtttggagcg ttccttttcg atttcccatt caatctgaac      240

agcgacctgg ccggtgctgt attgtgtgat gaaagagtcc actctggctg cagtgaaggt      300

tgtcgcagga taggcaggta cgggggtgtt tttgataaat atctggggag gcggatgttt      360

cagtccaaaa ccgccaatta gcggtgaagg atgaaaatgt ccgtccgcgt gtgggatctt      420

ggcccaaatt ggcccttggt agtaaatgtc tctgttttgc cacaccatgc caggaagcac      480

tcccatagca gtcacgttgc cggttatggg agcagttgta gcattctgat tattgtcagc      540

aatctgacca aacatgtccg tgtctcttgg gttggtggca gcaatttctt cttctgatgt      600

aaacaacaga ttgtttgctg aggttgttgt gtttccggtg actgatggtc cagggaagat      660

gagctgggcg ttgctgaagt ccccatctga aggtccagct gttgccattg gaggtccagg      720

cgctatgttg ctccagcggt tgtttaaggt atagtgggtg tcatacttta acagagcgtt      780

gcccccgctg gcaggaatct tgtaattttg actggcagtt tttgagaatc tctgctgttt      840

aacacaaggc ccaggcagcc agttctttct gtaaaaggca aagtctccac tcctgatttt      900

tccaaatgtg gttgctgcat tgccttgatt cagagtctct ccagaggtgg tcgactgtaa      960

gtgccacagg tactggtcca ggaggggatt catcagtccg tccaggctct ggctgtgagc     1020

atacattgag tggaacggca ccttctcaaa gttgtaagcc gtttcaaagt tattgccagt     1080

tctcagcatt tgtgaaggaa aatactccag gcagtagaaa gcatttctgt ccgtctggtt     1140

ctgattttcg ccagtcacaa tgccacagta gccatattga ggcaccatga agacgtcatt     1200

ggggaaagga ggcagacttc cctcttgtcc agcgtccatc acgtacggga gctcatacga     1260

cgagtccgca aatatctgaa ccgtgctggt aaggttatta gcgaccgtag tctcgccgtt     1320

cgacgttgtg acctccttaa cttggatatt gaagatttta acgcgcatgg cttttggtcg     1380

tagtccccag ttgttgttga tgagtctttg ccagtcacgt ggtgagaagt gacagtggaa     1440

tctgttaaag tcaaagtatc cccagggggt ggagaatccg ttgtaggtgt tgctgtttga     1500

tgttgttccg agccgcaggt acaagtggtt gttgtaggtg ggcaagaccc aggttctggt     1560

cgaggttgtt gtgaccttgc cctcagacca ggtggaatcg caatgccaat cacccgaggc     1620

attacccact ccatcggaac cttgtcccgc atcgacagca tttccgcccg gtgctgcacg     1680

catttcaatg tctgaagaca tggcgctggt atctgatcct tcagggggtc cgtctccggc     1740

tccagtgtcc tcttcaaagt tgagtctctt tttggctggt tgtttgcctt ttttgccgat     1800

tcctgaggag gagtcgggct cttgtggtga ctctaacggt ctcttctttc caggagccgt     1860

cttagcacct tcttcaacca ggcccagagg ttcgagtacc ctcttcttgg cctggaagac     1920

tgctcgcccg aggttgcccc caaaagacgt atcttcttgc agacgctcct gaaactcggc     1980

gtcggcgtgg ttataccgca ggtacggatt gtcacccgct ttgagctgct ggtcgtaggc     2040

cttgtcgtgc tcgagggccg ctgcgtccgc cgcgttgacg ggctccccct tgtcgagtcc     2100

gttgaagggt ccgaggtact cgtagccagg aagcaccaga ccccggccgt cgtcctgctt     2160

ctgctggttg gccttgggct tgggggctcc aggtttcagg tcccaccact cgcgaatgcc     2220

ctcagagagg ttgtcctcga gccaatctgg aagataaccg tcagcagcca tacctggttt     2280

aagtcattta ttgctcagaa acacagtcat ccaagtccac gttgacgaga tcgcaggccg     2340

aacacgcaat ctcgggtgcc cgccccagca gatgatgaat cgcgcacagt ttctgatacg     2400

tcttttttct gacgacgggt tgagattctg acgcgccggg gaagcactct gagcagtctc     2460

tgaccccgtg cgtgaagcag acgttgaaat tctgattcat tctctcgcat gtcttgcagg     2520

gaaacagcat ctgaagcatg cccgcgtgac gagaacattt gttttggtac ctgtccgcaa     2580

ggtccaccgg tgcttccgcg tctgacgtcg atggctccgc aactgagggg caggcccgct     2640

tgggctcgct tatatccgcg tcactggggg cgggtctttt ggtggctccg ccctttctga     2700

cgtagaactc atgcgccacc tcagtcacgt gatcctgagc ccagcggaag aactctttga     2760

cttcctgctt ggtcaccttg ccaaagtcgt gctccagacg gcgggtgagc tcgaacttga     2820

acatgcggtc ctgcagcggc tgctggtgct cgaaggtggt gctgttcccg tcgatcacgg     2880

cgcacatgtt ggtgttggag gtgacgatca cgggcgtggg gtcgatctgg gccgatgact     2940

tgcacttttg gtccacgcgc accttgcttc cgcccagaat ggccttggcg gactccacga     3000

ccttggcggt catcttgccc tcctcccacc agatcaccat cttgtcgacg caatcgttga     3060

agggaaagtt ctcattggtc cagttgacgc agcaagggcg aattc                     3105


<210> 5015
<211> 3094
<212> DNA
<213> Adeno-associated virus

<400> 5015
gaattcgccc ttgctgcgtc aactggacca agagaacttt cccttcaacg attgcgtcga       60

caagatggtg atctggtggg aggagggcaa gatgacggcc aaggtcgtgg agtccgccaa      120

agccattctg ggcggaagca aggtgcgcgt cgaccaaaag tgcaagtcct cggcccagat      180

cgatcccacc cccgtgatcg tcacctccaa caccaacatg tgcgccgtga tcgacgggaa      240

cagcaccacc ttcgagcacc agcagccgtt gcaggaccgg atgttcaaat ttgaactcac      300

ccgccgtctg gaacacgact ttggcaaggt gaccaagcag gaagtcaaag agttcttccg      360

ctgggctagt gatcacgtga ctgaggtgac gcatgagttc tacgtcagaa agggcggagc      420

cagcaaaaga cccgcccccg atgacgcgga tataagcgag cccaagcggg cctgtccctc      480

agtcacggac ccatcgacgt cagacgcgga aggagctccg gtggactttg ccgacaggta      540

ccaaaacaaa tgttctcgtc acgcgggcat gcttcagatg ctgtttccct gcaaaacgtg      600

cgagagaatg aatcagaatt tcaacatttg cttcacgcac ggggtcagag actgtttaga      660

atgtttcccc ggcgtgtcag aatctcaacc ggtcgtcaga aaaaagacgt atcggaagct      720

gtgtgcgatt catcatctgc tggggcgggc acccgagatt gcttgctcgg cctgcgacct      780

ggtcaacgtg gacctggacg actgtgtttc tgagcaataa atgacttaaa ccgggtatgg      840

ctgccgatgg ttatcttcca gattggctcg aggacaacct ctctgagggc attcgcgagt      900

ggtgggacct gaaacctgga gccccgaaac ccaaagccaa ccagcaaaag caggacgacg      960

gccggggtct ggtgcttcct ggctacaagt acctcggacc cttcaacgga ctcgacaagg     1020

gggagcccgt caacgcggcg gacgcagcgg ccctcgagca cgacaaggcc tacgaccagc     1080

agctcaaagc gggtgacaat ccgtacctgc ggtataacca cgccgacgcc gagtttcagg     1140

agcgtctgca agaagatacg tcatttgggg gcaacctcgg gcgagcagtc ttccaggcca     1200

agaagcgggt tctcgaacct ctcggtctgg ttgaggaagg cgctaagacg gctcctggaa     1260

agaagagacc catagactct ccagactcct ccacgggcat cggcaaaaaa ggccagcagc     1320

ccgctaaaaa gaagctcaat tttggtcaga ctggcgactc agagtcagtc cccgaccctc     1380

aacctcttgg agaacctcca gcagcgccct ctagtgtggg atctggtaca atggctgcag     1440

gcggtggcgc accaatggca gacaataacg aaggtgccga cggagtgggt aatgcctcag     1500

gaaattggca ttgcgattcc acatggctgg gcgacagagt catcaccacc agcaccagaa     1560

cctgggccct ccccacctac aacaaccacc tctacaagca aatctccagc agcagctcag     1620

gagccaccaa tgacaaccac tacttcggct acagcacccc ctgggggtat tttgacttta     1680

acagattcca ctgccacttc tcaccacgtg actggcagcg actcatcaac aacaactggg     1740

gattccggcc caagaagctg cggttcaagc tcttcaacat ccaggtcaag gaggtcacaa     1800

cgaatgacgg cgtcacgacc atcgctaata accttaccag cacggttcag gtcttctcgg     1860

actcggaata ccagctgccg tacgtcctcg gctctgcgca ccagggctgc ctgcctccgt     1920

tcccggcgga cgtcttcatg attcctcagt acggctacct gactctgaac aacggcagcc     1980

aatcggtggg ccgttcctcc ttctactgcc tggaatattt cccctctcaa atgctgagaa     2040

cgggcaacaa ctttgagttc agttacagct tcgaggacgt gcctttccac agcagctacg     2100

cgcacagcca gagcctagac cggctgatga accctctcat cgaccagtac ctgtactacc     2160

tggcccggac ccagagcacc acgggttcca ccagggaact gcaatttcat caagctgggc     2220

ccaatactat ggccgagcag tcaaagaact ggctgcctgg accctgctat aggcaacagg     2280

gactgtcaaa gaacttggac tttaacaaca acagcaattt tgcctggact gctgccacta     2340

aatatcatct gaatggcaga aactctttga ccaatcctgg cattcccatg gcaaccaaca     2400

aggatgatga ggaccagttc tttcccatca acggggtact ggtttttggc aagacgggag     2460

ctgccaacaa aactacgctg gaaaacgttc tgatgaccag cgaggaggag atcaagacca     2520

ctaaccctgt ggctacagaa gaatacggtg tggtctccag caacctgcag ccgtctacag     2580

ccgggcctca atcacagact atcaacagcc agggagcact gcctggcatg gtctggcaga     2640

accgggacgt gtatctgcag ggtcccatct gggccaaaat tcctcacacg gatggcaact     2700

ttcacccgtc tcctctgatg ggcggttttg gactcaaaca cccgcctcca cagatcctga     2760

tcaaaaacac acctgtacct gctaatcctc cggaggtgtt tactcctgcc aagtttgcct     2820

ccttcatcac gcagtacagc accggacaag tcagcgtgga aatcgagtgg gagctgcaga     2880

aagaaaacag caagcgctgg aacccagaaa ttcagtatac ttccaattat gccaagtcta     2940

ataatgttga atttgctgtg aaccctgatg gtgtttatac tgagcctcgc cccattggca     3000

ctcgttacct cccccgtaat ctgtaattgc ttgttaatca ataaaccggt tgattcgttt     3060

cagttgaact ttggtctctg cgaagggcga attc                                 3094


<210> 5016
<211> 3095
<212> DNA
<213> Adeno-associated virus

<400> 5016
gaattcgccc ttcgcagaga ccaaagttca actgaaacga atcaaccggt ttattgatta       60

acaagcaatt acagattacg ggtgaggtaa cgagtgccaa tggggcgagg ctcagtataa      120

acaccatcag ggttcacagc aaattcaaca ttattagact tggcataatt ggaagtatac      180

tgaatttctg ggttccagcg cttgctgttt tctttctgca gctcccactc gatttccacg      240

ctgacttgtc cggtgctgta ctgcgtgatg aaggaggcaa acttggcagg agtaaacacc      300

tccggaggat tagcaggtac aggtgtgttt ttgatcagga tctgtggagg cgggtgtttg      360

agtccaaaac cgcccatcag aggagacggg tgaaagttgc catccgtgtg aggaattttg      420

gcccagatgg gaccctgcag atacacgtcc cggttctgcc agaccatgcc aggcagtgct      480

ccctggctgt tgatagtctg tgattgaggc ccggctgtag acgactgcag gttgctggag      540

accacaccgt attcttctgt agccacaggg ttagtggtct tgatctcctc ctcgctggtc      600

atcagaacgt tttccagcgt agttttgttg gcagctcccg tcttgccaaa aaccagtacc      660

ccgttgatgg gaaagaactg gtcctcatca tccttgttgg ttgccatggg aatgccagga      720

ttggtcaaag agtttctgcc attcagatga tatttagtgg cagcagtcca ggcaaaattg      780

ctgttgttgt taaagtccaa gttctttgac agtctctgtt gcctatagca gggtccaggc      840

agccagttct ttgactgctc ggccatagta ttgggcccag cttgatgaaa ttgcagttcc      900

ctggtggaac ccgtggtgct ctgggtccgg gccaggtagt acaggtactg gtcgatgaga      960

gggttcatca gccggtctag gctctggctg tgcgcgtagc tgctgtggaa aggcacgtcc     1020

tcgaagctgt aactgaactc aaagttgttg cccgttctca gcatttgaga ggggaaatat     1080

tccaggcagt agaaggagga acggcccacc gattggctgc cgttgtccag agtcaggtag     1140

ccgtactgag gaatcatgaa gacgtccgcc gggaacggag gcaggcagcc ctggtgcgca     1200

gagccgagga cgtacggcag ctggtattcc gagtccgaga agacctgaac cgtgctggta     1260

aggttattag cgatggtcgt gacgccgtca ttcgttgtga cctccttgac ctggatgttg     1320

aggagcttga accgcagctt cttgggccgg aatccccagt tgttgttgat gagtcgctgc     1380

cagtcacgtg gtgagaagtg gcagtggaat ctgttaaagt caaaataccc ccagggggtg     1440

ctgtagccga agtagtggtt gtcattggtg gctcctgagc tgctgctgga gatttgcttg     1500

tagaggtggt tgttgtaggt ggggagggcc caggttctgg tgctggtggt gatgactctg     1560

tcgcccagcc atgtggaatc gcaatgccaa tttcctgagg cattacccac tccgtcggca     1620

ccttcgttat tgtctgccat tggtgcgcca ccgcctgcag ccattgtacc agatcccaca     1680

ctagagggcg ctgctggagg ttctccaaga ggttgagggt cggggactga ctctgagtcg     1740

ccagtctgac caaaattgag cttcttttta gcgggctgct ggcctttttt gccgatgccc     1800

gtggaggagt ctggagagcc tatgggtctc ttctttccag gagccgtctt agcgccttcc     1860

tcaaccagac cgagaggttc gagaacccgc ttcttggcct ggaagactgc tcgcccgagg     1920

ttgcccccaa atgacgtatc ttcttgcaga cgctcctgaa actcggcgtc ggcgtggtta     1980

taccgcaggt acggattgtc acccgctttg agctgctggt cgtaggcctt gtcgtgctcg     2040

agggccgctg cgtccgccgc gttgacgggc tcccccttgt cgagtccgtt gaagggtccg     2100

aggtacttgt agccaggaag caccagaccc cggccgtcgt cctgcttttg ctggttggct     2160

ttgggtttcg gggctccagg tttcaggtcc caccactcgc gaatgccctc agagaggttg     2220

tcctcgagcc aatctggaag ataaccatcg gcagccatac ctggtttaag tcatttattg     2280

ctcagaaaca cagtcgtcca ggtccacgtt gaccaggtcg caggccgagc aagcaatctc     2340

gggtgcccgc cccagcagat gatgaatcgc acacagcttc cgatacgtct tttttctgac     2400

gaccggttga gattctgaca cgccggggaa acattctaaa cagtctctga ccccgtgcgt     2460

gaagcaaatg ttgaaattct gattcattct ctcgcacgtt ttgcagggaa acagcacctg     2520

aagcatgccc gcgtgacgag aacatttgtt ttggtacctg tcggcaaagt ccaccggagc     2580

tccttccgcg tctgacgtcg atgggtccgt gactgaggga cgggcccgct tgggctcgct     2640

tatatccgcg tcatcggggg cgggtctttt gctggctccg ccctttctga cgtagaactc     2700

atgcgtcacc tcagtcacgt gatcactagc ccagcggaag aactctttga cttcctgctt     2760

tgtcaccttg ccaaagtcgt gttccagacg gcgggtgagt tcaaatttga acatccggtc     2820

ctgcaacggt tgctggtgct cgaaggtggt gctgttcccg tcgatcacgg cgcacatgtt     2880

ggtgttggag gtgacgatca cgggggtggg atcgatctgg gcggacgact tgcacttttg     2940

gtccacgcgc accttgctgc cgccgagaat ggccttggcg gactccacga ccttggccgt     3000

catcttgccc tcctcccacc agatcaccat cttgtcgacg caatcgttga agggaaagtt     3060

ctcattggtc cagttgacgc agcaagggcg aattc                                3095


<210> 5017
<211> 3095
<212> DNA
<213> Adeno-associated virus

<400> 5017
gaattcgccc ttcgcagaga ccaaagttca actgaaacga atcaaccggt ttattgatta       60

acaagcaatt acagattacg ggtgaggtaa cgagtgccaa tggggcgagg ctcagtataa      120

acaccatcag ggttcacagc aaattcaaca ttattagact tggcataatt ggaagtatac      180

tgaatttctg ggttccagcg cttgctgttt tctttctgca gctcccactc gatttccacg      240

ctgacttgtc cggtgctgta ctgcgtgatg aaggaggcaa acttggcagg agtaaacacc      300

tccggaggat tagcaggtac aggtgtgttt ttgatcagga tctgtggagg cgggtgttcg      360

agtccaaaac cgcccatcag aggagacggg tgaaagttgc catccgtgtg aggaattttg      420

gcccagatgg gaccctgcag atacacgtcc cggttctgcc agaccatgcc aggcagtgct      480

ccctggctgt tgatagtctg tgattgaggc ccggctgtag acgactgcag gttgctggag      540

accacaccgt attcttctgt agccacaggg ttagtggtct tgatctcctc ctcgctggtc      600

atcagaacgt tttccagcgt agttttgttg gcagctcccg tcttgccaaa aaccagtacc      660

ccgttgatgg gaaagaactg gtcctcatca tccttgttgg ttgccatggg aatgccagga      720

ttggtcaaag agtttctgcc attcagatga tatttagtgg cagcagtcca ggcaaaattg      780

ctgttgttgt taaagtccaa gttctttgac agtctctgtt gcctatagca gggtccaggc      840

agccagttct ttgactgctc ggccatagta ttgggcccag cttgatgaaa ttgcagttcc      900

ctggtggaac ccgtggtgct ctgggtccgg gccaggtagt acaggtactg gtcgatgaga      960

gggttcatca gccggtctag gctctggctg tgcgcgtagc tgctgtggaa aggcacgtcc     1020

tcgaagctgt aactgaactc aaagttgttg cccgttctca gcatttgaga ggggaaatat     1080

tccaggcagt agaaggagga acggcccacc gattggctgc cgttgttcag agtcaggtag     1140

ccgtactgag gaatcatgaa gacgtccgcc gggaacggag gcaggcagcc ctggtgcgca     1200

gagccgagga cgtacggcag ctggtattcc gagtccgaga agacctgaac cgtgctggta     1260

aggttattag cgatggtcgt gacgccgtca ttcgttgtga cctccttgac ctggatgttg     1320

aagagcttga accgcagctt cttgggccgg aatccccagt tgttgttgat gagtcgctgc     1380

cagtcacgtg gtgagaagtg gcagtggaat ctgttaaagt caaaataccc ccagggggtg     1440

ctgtagccga agtagtggtt gtcattggtg gctcctgagc tgctgctgga gatttgcttg     1500

tagaggtggt tgttgtaggt ggggagggcc caggttctgg tgctggtggt gatgactctg     1560

tcgcccagcc atgtggaatc gcaatgccaa tttcctgagg cattacccac tccgtcggca     1620

ccttcgttat tgtctgccgt tggtgcgcca ccgcctgcag ccattgtacc agatcccaca     1680

ctagagggcg ctgctggagg ttctccaaga ggttgagggt cggggactga ctctgagtcg     1740

ccagtctgac caaaattgag cttcttttta gcgggctgct ggcctttttt gccgatgccc     1800

gtggaggagt ctggagagtc tatgggtctc ttctttccag gagccgtctt agcgccttcc     1860

tcaaccagac cgagaggttc gagaacccgc ttcttggcct ggaagactgc tcgcccgagg     1920

ttgcccccaa atgacgtatc ttcttgcagg cgctcctgaa actcggcgtc ggcgtggtta     1980

taccgcaggt acggattgtc acccgctttg agctgctggt cgtaggcctt gtcgtgctcg     2040

agggccgctg cgtccgccgc gttgacgggc tcccccttgt cgagtccgtt gaagggtccg     2100

aggtacttgt agccaggaag caccagaccc cggccgtcgt cctgcttttg ctggttggct     2160

ttgggtttcg gggctccagg tttcaggtcc caccactcgc gaatgccctc agagaggttg     2220

tcctcgagcc aatctggaag ataaccatcg gcagccatac ctggtttaag ccatttattg     2280

ctcagaaaca cagtcgtcca ggtccacgtt gaccaggtcg caggccgagc aggcaatctc     2340

gggtgcccgc cccagcagat gatgaatcgc acacagcttc cgatacgtct tttttctgac     2400

gaccggttga gattctgaca cgccggggaa acattctaaa cagtctctga ccccgtgcgt     2460

gaagcaaatg ttgaaattct gattcattct ctcgcacgtt ttgcagggaa acagcatctg     2520

aagcatgccc gcgtggcgag aacatttgtt ttggtacctg tcggcaaagt ccaccggagc     2580

tccttccgcg tctgacgtcg atgggtccgt gactgaggga caggcccgct tgggctcgct     2640

tatatccgcg tcatcggggg cgggtctttt gctggctccg ccctttctga cgtagaactc     2700

atgcgtcacc tcagtcacgt gatcactagc ccagcggaag aactctttga cttcctgctt     2760

tgtcaccttg ccaaagtcgt gttccagacg gcgggtgagt tcaaatttga acatccggtc     2820

ctgcaacggc tgctggtgct cgaaggtggt gctgttcccg tcgatcacgg cgcgcatgtt     2880

ggtgttggag gtgacgatca cgggggtggg atcgatctgg gcggacgact tgcacttttg     2940

gtccacgcgc accttgctgc cgccgagaat ggccttggcg gactccacga ccttggccgt     3000

catcttgccc tcctcccacc agatcaccat cttgtcgacg caatcgttga agggaaagtt     3060

ctcattggtc cagttgacgc agcaagggcg aattc                                3095


<210> 5018
<211> 729
<212> PRT
<213> Adeno-associated virus

<400> 5018
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Asp Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Thr Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Ser Ser Ser Gly Ala Thr Asn Asp Asn His Tyr Phe Gly Tyr 
            260                 265                 270         


Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe 
        275                 280                 285             


Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg 
    290                 295                 300                 


Pro Lys Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val 
305                 310                 315                 320 


Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr 
                325                 330                 335     


Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly 
            340                 345                 350         


Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met 
        355                 360                 365             


Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val 
    370                 375                 380                 


Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu 
385                 390                 395                 400 


Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Ser Phe Glu Asp Val Pro 
                405                 410                 415     


Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn 
            420                 425                 430         


Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr 
        435                 440                 445             


Thr Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr 
    450                 455                 460                 


Met Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln 
465                 470                 475                 480 


Gln Arg Leu Ser Lys Asn Leu Asp Phe Asn Asn Asn Ser Asn Phe Ala 
                485                 490                 495     


Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr 
            500                 505                 510         


Asn Pro Gly Ile Pro Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe 
        515                 520                 525             


Phe Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn 
    530                 535                 540                 


Lys Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys 
545                 550                 555                 560 


Thr Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn 
                565                 570                 575     


Leu Gln Ser Ser Thr Ala Gly Pro Gln Ser Gln Thr Ile Asn Ser Gln 
            580                 585                 590         


Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln 
        595                 600                 605             


Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro 
    610                 615                 620                 


Ser Pro Leu Met Gly Gly Phe Gly Leu Glu His Pro Pro Pro Gln Ile 
625                 630                 635                 640 


Leu Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr 
                645                 650                 655     


Pro Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val 
            660                 665                 670         


Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp 
        675                 680                 685             


Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val 
    690                 695                 700                 


Glu Phe Ala Val Asn Pro Asp Gly Val Tyr Thr Glu Pro Arg Pro Ile 
705                 710                 715                 720 


Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 


<210> 5019
<211> 729
<212> PRT
<213> Adeno-associated virus

<400> 5019
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Asp Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Thr Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Ser Ser Ser Gly Ala Thr Asn Asp Asn His Tyr Phe Gly Tyr 
            260                 265                 270         


Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe 
        275                 280                 285             


Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg 
    290                 295                 300                 


Pro Lys Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val 
305                 310                 315                 320 


Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr 
                325                 330                 335     


Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly 
            340                 345                 350         


Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met 
        355                 360                 365             


Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val 
    370                 375                 380                 


Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu 
385                 390                 395                 400 


Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Ser Phe Glu Asp Val Pro 
                405                 410                 415     


Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn 
            420                 425                 430         


Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr 
        435                 440                 445             


Thr Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr 
    450                 455                 460                 


Met Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln 
465                 470                 475                 480 


Gln Arg Leu Ser Lys Asn Leu Asp Phe Asn Asn Asn Ser Asn Phe Ala 
                485                 490                 495     


Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr 
            500                 505                 510         


Asn Pro Gly Ile Pro Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe 
        515                 520                 525             


Phe Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn 
    530                 535                 540                 


Lys Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys 
545                 550                 555                 560 


Thr Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn 
                565                 570                 575     


Leu Gln Ser Ser Thr Ala Gly Pro Gln Ser Gln Thr Ile Asn Ser Gln 
            580                 585                 590         


Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln 
        595                 600                 605             


Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro 
    610                 615                 620                 


Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile 
625                 630                 635                 640 


Leu Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr 
                645                 650                 655     


Pro Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val 
            660                 665                 670         


Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp 
        675                 680                 685             


Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val 
    690                 695                 700                 


Glu Phe Ala Val Asn Pro Asp Gly Val Tyr Thr Glu Pro Arg Pro Ile 
705                 710                 715                 720 


Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 


<210> 5020
<211> 729
<212> PRT
<213> Adeno-associated virus

<400> 5020
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Ile Asp Ser Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln 
145                 150                 155                 160 


Gln Pro Ala Lys Lys Lys Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu 
                165                 170                 175     


Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser 
            180                 185                 190         


Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala 
        195                 200                 205             


Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile 
                245                 250                 255     


Ser Ser Ser Ser Ser Gly Ala Thr Asn Asp Asn His Tyr Phe Gly Tyr 
            260                 265                 270         


Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe 
        275                 280                 285             


Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg 
    290                 295                 300                 


Pro Lys Lys Leu Arg Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val 
305                 310                 315                 320 


Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr 
                325                 330                 335     


Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly 
            340                 345                 350         


Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met 
        355                 360                 365             


Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ser Val 
    370                 375                 380                 


Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu 
385                 390                 395                 400 


Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Ser Phe Glu Asp Val Pro 
                405                 410                 415     


Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn 
            420                 425                 430         


Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Thr 
        435                 440                 445             


Thr Gly Ser Thr Arg Glu Leu Gln Phe His Gln Ala Gly Pro Asn Thr 
    450                 455                 460                 


Met Ala Glu Gln Ser Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln 
465                 470                 475                 480 


Gln Arg Leu Ser Lys Asn Leu Asp Phe Asn Asn Asn Ser Asn Phe Ala 
                485                 490                 495     


Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Thr 
            500                 505                 510         


Asn Pro Gly Ile Pro Met Ala Thr Asn Lys Asp Asp Glu Asp Gln Phe 
        515                 520                 525             


Phe Pro Ile Asn Gly Val Leu Val Phe Gly Lys Thr Gly Ala Ala Asn 
    530                 535                 540                 


Lys Thr Thr Leu Glu Asn Val Leu Met Thr Ser Glu Glu Glu Ile Lys 
545                 550                 555                 560 


Thr Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Val Val Ser Ser Asn 
                565                 570                 575     


Leu Gln Ser Ser Thr Ala Gly Pro Gln Ser Gln Thr Ile Asn Ser Gln 
            580                 585                 590         


Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln 
        595                 600                 605             


Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro 
    610                 615                 620                 


Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile 
625                 630                 635                 640 


Leu Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Glu Val Phe Thr 
                645                 650                 655     


Pro Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val 
            660                 665                 670         


Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp 
        675                 680                 685             


Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Asn Asn Val 
    690                 695                 700                 


Glu Phe Ala Val Asn Pro Asp Gly Val Tyr Thr Glu Pro Arg Pro Ile 
705                 710                 715                 720 


Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 


<210> 5021
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 5021
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tacaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcggcc cgctaaaaag agactgaact ttggtcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atatccaatg ggacatcggg aggaagcacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt caacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg ccaaaaagac tcagcttcaa gcccttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taaccttacc     1020

agcacgattc aggtatttac ggactcggaa taccagctgc cgtacgtcct cggctccgcg     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcccca gtacggctac     1140

cttacactga acaatggaag tcaagccgta ggccgttcct ccttctactg cctggaatat     1200

tttccatctc aaatgctgcg aactggaaac aattttgaat tcagctacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcacacagc cagagcttgg accgactgat gaatcctctc     1320

atcgaccagt acctgcacta cttatccaga actcagtcca caggaggaac tcaaggtacc     1380

cagcaattgt tattttctca agctgggcct gcaaacatgt cggctcaggc taagaactgg     1440

ctacctggac cttgctaccg gcagcagcga gtctctacga cactgtcgca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa tatcacctga acggaagaga ctctttggta     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccgtcgagt     1620

ggagtcctga tgtttggaaa acagggtgct ggaagagaca atgtggacta cagcagcgtt     1680

atgctaacca gcgaagaaga aattaaaacc actaaccctg tagccacaga acaatacggt     1740

gtggtggctg acaacttgca gcaaaccaat acagggccta ttgtgggaaa tgtcaacagc     1800

caaggagcct tacctggcat ggtctggcag aaccgagacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccaccctt caccgctaat gggaggattt     1920

ggactgaagc acccacctcc tcagatcctg atcaagaaca cgccggtacc tgcggatcct     1980

ccaacaacgt tcagccaggc gaaattggct tccttcatta cgcagtacag caccggacag     2040

gtcagcgtgg aaatcgagtg ggagctgcag aaggagaaca gcaaacgctg gaacccagag     2100

attcagtaca cttcaaacta ctacaaatct acaaatgtgg actttgctgt caatacagag     2160

ggaacttatt ctgagcctcg ccccattggt actcgctacc tcacccgtaa tctgtaa        2217


<210> 5022
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5022
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Arg Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Pro Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu His Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5023
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 5023
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctaaaaag agactgaact ttggtcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atatccaatg ggacatcggg aggaagcacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt caacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg ccaaaaagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taaccttacc     1020

agcacgattc aggtatttac ggactcggaa taccagctgc cgtacgtcct cggctccgcg     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcccca gtacggctac     1140

cttacactga acaatggaag tcaagccgta ggccgttcct ccttctactg cctggaatat     1200

tttccatctc aaatgctgcg aactggaaac aattttgaat tcagctacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcacacagc cagagcttgg accgactgat gaatcctctc     1320

atcgaccagt acctgtacta cttatccaga actcagtcca caggaggaac tcaaggtacc     1380

cagcaattgt tattttctca agctgggcct gcaaacatgt cggctcaggc taagaactgg     1440

ctacctggac cttgctaccg gcagcagcga gtctctacga cactgtcgca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa tatcacctga acggaagaga ctctttggta     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccgtcgagt     1620

ggagtcctga tgtttggaaa acagggtgct ggaagagaca atgtggacta cagcagcgtt     1680

atgctaacca gcgaagaaga aattaaaacc actaaccctg tagccacaga acaatacggt     1740

gtggtggctg ataacttgca gcaaaccaat acggggccta ttgtgggaaa tgtcaacagc     1800

caaggagcct tacctggcat ggtctggcag aaccgagacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccaccctt caccgctaat gggaggattt     1920

ggactgaagc acccacctcc tcagatcctg atcaagaaca cgccggtacc tgcggatcct     1980

ccaacaacgt tcagccaggc gaaattggct tccttcatta cgcagtacag caccggacag     2040

gtcagcgtgg aaatcgagtg ggagctgcag aaggagaaca gcaaacgctg gaacccagag     2100

attcagtaca cttcaaacta ctacaaatct acaaatgtgg actttgctgt caatacagag     2160

ggaacttatt ctgagcctcg ccccattggt actcgttacc tcacccgtaa tctgtaa        2217


<210> 5024
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5024
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5025
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5025
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asp Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Arg Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Ala Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Ser Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5026
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 5026
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctaaaaag agactgaact ttggtcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atatccaatg ggacatcggg aggaagcacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt caacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg ccaaaaagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcaggatgaa ggcaccaaga ccatcgccaa taaccttacc     1020

agcacgattc aggtatttac ggactcggaa taccagctgc cgtacgtcct cggctccgcg     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcccca gtacggctac     1140

cttacactga acaatggaag tcaagccgta ggccgttcct ccttctactg cctggaatat     1200

tttccatctc aaatgctgcg aactggaaac aattttgaat tcagctacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcacacagc cagagcttgg accgactgat gaatcctctc     1320

atcgaccagt acctgtacta cttatccaga actcagtcca caggaggaac tcaaggtacc     1380

cagcaattgt tattttctca agctgggcct gcaaacatgt cggctcgggc taagaactgg     1440

ctacctggac cttgctaccg gcagcagcga gtctctacga cactgtcgca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa tatcacctga acggaagaga ctctttggta     1560

aatcccggtg ttgctatggc aacgcataag gacgacgagg aacgtttctt tccatcgagc     1620

ggagtcctga tgtttggaaa acagggtgct ggaagagaca atgtggacta tagcagcgtt     1680

atgctaacca gcgaggaaga aattaaaacc actaaccctg tagccacaga acaatacggt     1740

gtggtggctg acaacttgca gcaagccaat acagggccta ttgtgggaaa tgtcaacagc     1800

caaggagcct tacctggcat ggtctggcag aaccgagacg tgtacctgca gggtcccatc     1860

tgggccaaaa ttcctcacac ggacggcaat tttcacccgt ctcctctgat gggcggcttt     1920

ggactgaagc acccacctcc ccagatcctg atcaagaata cgccggtacc tgcggatcct     1980

ccaacgacgt tcagccaggc aaaattggct tccttcatca cgcagtacag caccggccag     2040

gtcagcgtgg agatcgagtg ggagctgcag aaggagaaca gcaagcgatg gaacccagaa     2100

attcagtaca cttccaacta ctacaaatct acaaatgtgg actttgctgt caattctgag     2160

ggtacatatt cagagcctcg ccccattggt actcgttatc tgacacgtaa tctgtaa        2217


<210> 5027
<211> 2211
<212> DNA
<213> Adeno-associated virus

<400> 5027
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gcctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctcg aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccagtaga gcagtcaccc caagaaccag actcctcctc gggcatcggc      480

aagaaaggcc aacagcccgc cagaaaaaga ctcaattttg gccagactgg cgactcagag      540

tcagttccag accctcaacc tctcggagaa cctccagcag cgccctctgg tgtgggacct      600

aatacaatgg ctgcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caagcaaatc      780

tccaacggga catcgggagg agccaccaac gacaacacct acttcggcta cagcaccccc      840

tgggggtatt ttgactttaa cagattccac tgccactttt caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggccc aagagactca gcttcaagct cttcaacatc      960

caggtcaagg aggtcacgca gaatgaaggc accaagacca tcgccaataa cctcaccagc     1020

accatccagg tgtttacgga ctcggagtac cagctgccgt acgttctcgg ctctgcccac     1080

cagggctgcc tgcctccgtt cccggcggac gtgttcatga ttccccagta cggctaccta     1140

acactcaaca acggtagtca ggccgtggga cgctcctcct tctactgcct ggaatacttt     1200

ccttcgcaga tgctgagaac cggcaacaac ttccagttta cttacacctt cgaggacgtg     1260

cctttccaca gcagctacgc ccacagccag agcttggacc ggctgatgaa tcctctgatt     1320

gaccagtacc tgtactactt gtctcggact caaacaacag gaggcacggc aaatacgcag     1380

actctgggct tcagccaagg tgggcctaat acaatggcca atcaggcaaa gaactggctg     1440

ccaggaccct gttaccgcca acaacgcgtc tcaacgacaa ccgggcaaaa caacaatagc     1500

aactttgcct ggactgctgg gaccaaatac catctgaatg gaagaaattc attggctaat     1560

cctggcatcg ctatggcaac acacaaagac gacgaggagc gttttttccc agtaacggga     1620

tcctgttttt ggcaacaaaa tgctgccaga gacaatgcgg attacagcga tgtcatgctc     1680

accagcgagg aagaaatcaa aaccactaac cctgtggcta cagaggaata cggtatcgtg     1740

gcagataact tgcagcagca aaacacggct cctcaaattg gaactgtcaa cagccagggg     1800

gccttacccg gtatggtctg gcagaaccgg gacgtgtacc tgcagggtcc catctgggcc     1860

aagattcctc acacggacgg caacttccac ccgtctccgc tgatgggcgg ctttggcctg     1920

aaacatcctc cgcctcagat cctgatcaag aacacgcctg tacctgcgga tcctccgacc     1980

accttcaacc agtcaaagct gaactctttc atcacgcaat acagcaccgg acaggtcagc     2040

gtggaaattg aatgggagct acagaaggaa aacagcaagc gctggaaccc cgagatccag     2100

tacacctcca actactacaa atctacaagt gtggactttg ctgttaatac agaaggcgtg     2160

tactctgaac cccgccccat tggcacccgt tacctcaccc gtaatctgta a              2211


<210> 5028
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 5028
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly Phe 
    450                 455                 460                 


Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly Gln 
                485                 490                 495     


Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His Leu 
            500                 505                 510         


Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr His 
        515                 520                 525             


Lys Asp Asp Glu Glu Arg Phe Phe Pro Val Thr Gly Ser Cys Phe Trp 
    530                 535                 540                 


Gln Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val Met Leu 
545                 550                 555                 560 


Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala Pro Gln 
            580                 585                 590         


Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 5029
<211> 2214
<212> DNA
<213> Adeno-associated virus

<400> 5029
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcagcgc ggcggacgca gcggccctcg agcacgacaa ggcctgcgac      240

cagcggctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaagg gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctagaaag agactgaact ttgggcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggctg acaataacga gggcgccgac      660

ggagtgggta atgcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggctttg cccacctaca acaatcacct ctacaagcaa      780

atctccagtc agtcagcagg tagcaccaac gacaacgtct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgtcacttct caccacgtga ctggcagcgg      900

ctcatcaaca acaactgggg attccggccc aagaagctca acttcaagct gttcaacatc      960

caggtcaagg aggtcacaac gaatgacggc gtcacgacca tcgccaataa ccttaccagc     1020

acggttcagg tcttttcgga ctcggaatac cagctgccct acgtcctcgg ctccgcacac     1080

cagggctgcc tgcctccgtt cccggcggac gtcttcatga ttccccagta cggctacctg     1140

actctgaaca atggcagcca atcggtgggt cgttcctctt tctactgcct ggaatatttc     1200

ccttctcaaa tgctgagaac gggcaacaac ttcaccttca gctacacctt cgaggacgtt     1260

cccttccaca gcagctacgc acacagccag agcctggacc ggctgatgaa tcctcttatc     1320

gaccagtacc tgtattacct ggccagaaca cagagcaacg caggaggcac agctggcaat     1380

cgggaactgc agttttatca gggcgggcct accaccatgg ccgaacaagc caaaaactgg     1440

ctgcctggac cttgcttccg gcaacaaaga gtctccaaga cgctggatca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa taccatctaa atggaagaaa ttcattggtt     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccttcgagc     1620

ggagtcctga tttttggaaa aactggagca gctaataaga ctacactgga aaatgtgtta     1680

atgacaaatg aagaggaaat tcgtcctacc aacccggtag ccaccgagga atacgggact     1740

gttagcagca acctgcaggc ggctaacact gcagcccaga cacaagttgt caacaaccag     1800

ggagccttac ctggtatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga cggcaacttt cacccgtctc cgctgatggg cggctttgga     1920

ctgaagcatc cgcctcctca gatcctgatc aaaaacactc ctgttcctgc taatcccccg     1980

gaggtgttta cgcctgccaa gtttgcttct ttcatcacac agtacagcac cggccaggtc     2040

agcgtggaga tcgagtggga gctgcagaag gagaacagca agcgctggaa cccagagatt     2100

cagtatacct ccaattttga cgaacagact ggtgtggact ttgccgttga cagccagggt     2160

gtttattctg agcctcgccc cattggtact cgttacctca cccgtaatct gtaa           2214


<210> 5030
<211> 737
<212> PRT
<213> Adeno-associated virus

<400> 5030
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Ser Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Cys Asp 
65                  70                  75                  80  


Gln Arg Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Gly 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Thr Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Asp Glu Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5031
<211> 2214
<212> DNA
<213> Adeno-associated virus

<400> 5031
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctagaaag agactgaact ttgggcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta atgcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggctttg cccacctaca acaaccacct ctacaagcaa      780

atctccagtc agtcagcagg tagcaccaac gacaacgtct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgtcacttct caccacgtga ctggcagcgg      900

ctcatcaaca acaactgggg attccggccc aagaagctca acttcaagct gttcaacatc      960

caggtcaagg aggtcacaac gaatgacggc gtcacgacca tcgccaataa ccttaccagc     1020

acggttcagg tcttttcgga ctcggaatac cagctgccct acgtcctcgg ctccgcacac     1080

cagggctgcc tgcctccgtt cccggcggac gtcttcatga ttcctcagta cggctacctg     1140

actctcaaca acggtagtca ggccgtggga cgttcctcct tctactgcct ggagtacttc     1200

ccctctcaga tgctgagaac gggcaacaac ttttccttca gctacacttt cgaggacgtg     1260

cctttccaca gcagctacgc gcacagccag agtttggaca ggctgatgaa tcctctcatc     1320

gaccagtacc tgtactacct gtcaagaacc cagtctacgg gaggcacagc gggaacccag     1380

cagttgctgt tttctcaggc cgggcctagc aacatgtcga ctcaggccag aaactggctg     1440

cctggaccct gctacagaca gcagcgcgtc tccacgacac tgtcgcaaaa caacaacagc     1500

aactttgcct ggactggtgc caccaagtat catctgaacg gcagagactc tctggtgaat     1560

ccgggcgtcg ccatggcaac caacaaggac gacgaggacc gcttcttccc atccagcggc     1620

atcctcatgt ttggcaagca gggagctgga aaagacaacg tggactatag caacgtgatg     1680

ctaaccagcg aggaagaaat caagaccacc aaccccgtgg ccacagaaca gtatggcgtg     1740

gtggctgata acctacagca gcaaaacacc gctcctattg tgggggccgt caacagccag     1800

ggagccttac ctggcatggt ctggcagaac cgggacgtgt acctgcaggg tcctatttgg     1860

gccaagattc ctcacacaga tggcaacttt cacccgtctc ctttaatggg cggctttgga     1920

cttaaacatc cgcctcctca gatccttatc aaaaacactc ctgttcctgc ggatcctcca     1980

acagcgttca accaggccaa gctgaattct ttcatcacgc agtacagcac cggacaagtc     2040

agcgtggaga tcgagtggga gctgcagaag gagaacagca agcgctggaa cccagagatt     2100

cagtatactt ccaactacta caaatctaca aatgtggact ttgctgttaa tactgagggt     2160

gcttactctg agcctcgccc cattggcact cgttacctca cccgtaatct gtaa           2214


<210> 5032
<211> 737
<212> PRT
<213> Adeno-associated virus

<400> 5032
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu Phe 
    450                 455                 460                 


Ser Gln Ala Gly Pro Ser Asn Met Ser Thr Gln Ala Arg Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser Gln 
                485                 490                 495     


Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His Leu 
            500                 505                 510         


Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr Asn 
        515                 520                 525             


Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met Phe 
    530                 535                 540                 


Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val Met 
545                 550                 555                 560 


Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala Pro 
            580                 585                 590         


Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly 
705                 710                 715                 720 


Ala Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5033
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 5033
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacctcggg aggcagcacc aacgacaaca cctactttgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggaa taccagctgc cgtacgtcct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcctca gtacggctac     1140

ctgactctca acaacggtag tcaggccgtg ggacgttcct ccttctactg cctggagtac     1200

ttcccctctc agatgctgag aacgggcaac aacttttcct tcagctacac tttcgaggac     1260

gtgcctttcc acagcagcta cgcgcacagc cagagtttgg acaggctgat gaatcctctc     1320

atcgaccagt acctgtacta cctgtcaaga acccagtcta cgggaggcac agcgggaacc     1380

cagcagttgc tgttttctca ggccgggcct agcaacatgt cggctcaggc cagaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga acggcagaga ctctctggtg     1560

aatccgggcg tcgccatggc aaccaacaag gacgacgagg accgcttctt cccatccagc     1620

ggcatcctca tgtttggcaa gcagggagct ggaaaagaca acgtggacta tagcaacgtg     1680

atgctaacca gcgaggaaga aatcaaggcc accaaccccg tggccacaga acagtatggc     1740

gtggtggctg ataacctaca gcagcaaaac accgctccta ttgtgggggc cgtcaacagc     1800

cagggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatt     1860

tgggccaaga ttcctcacac agatggcaac tttcacccgt ctcctttaat gggcggcttt     1920

ggacttaaac atccgcctcc tcagatcctc atcaaaaaca ctcctgttcc tgcggatcct     1980

ccaacagcgt tcaaccaggc caagctgaat tctttcatca cgcagtacag caccggacaa     2040

gtcagcgtgg agatcgagtg ggagctgcag aaggagaaca gcaagcgctg gaacccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgtgg actttgctgt taatactgag     2160

ggtgtttact ctgagcctcg ccccattggc actcgttacc tcacccgtaa tctgtaa        2217


<210> 5034
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5034
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5035
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 5035
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagcacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgctga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacctcggg aggcagcacc aacgacaaca cctactttgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taaccttacc     1020

agcacggttc aggtcttttc ggactcggaa taccagctgc cctacgtcct cggctccgca     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcccca gtacggctac     1140

ctgactctga acaatggcag ccaatcggtg ggtcgttcct ctttctactg cctggaatat     1200

ttcccttctc aaatgctgag aacgggcaac aacttcacct tcagctacac cttcgaggac     1260

gttcccttcc acagcagcta cgcacacagc cagagcctgg accggctgat gaatcctctt     1320

atcgaccagt acctgtatta cctggccaga acacagagca acgcaggagg cacagctggc     1380

aatcgggaac tgcagtttta tcagggcggg cctaccacca tggccgaaca agccaaaaac     1440

tggctgcctg gaccttgctt ccggcaacaa agagtctcca agacgctgga tcaaaacaac     1500

aacagcaact ttgcttggac tggtgccacc aaataccatc taaatggaag aaattcattg     1560

gttaatcccg gtgtcgccat ggcaacccac aaggacgacg aggaacgctt cttcccttcg     1620

agcggagtcc tgatttttgg aaaaactgga gcagctaata agactacact ggaaaatgtg     1680

ttaatgacaa atgaagagga aattcgtcct accaacccgg tagccaccga ggaatacggg     1740

actgttagca gcaacctgca ggcggctaac actgcagccc agacacaagt tgtcaacaac     1800

cagggagcct tacctggtat ggtctggcag aaccgggacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac tttcacccgt ctccgctgat gggcggcttt     1920

ggactgaagc atccgcctcc tcagatcctg atcaaaaaca ctcctgttcc tgctaatccc     1980

ccggaggtgt ttacgcctgc caagtttgct tctttcatca cacagtacag caccggccag     2040

gtcagcgtgg agatcgagtg ggagctgcag aaggagaaca gcaagcgctg gaacccagag     2100

attcagtata cctccaattt tgacaaacag actggtgtgg actttgccgt tgacagccag     2160

ggtgtttatt ctgagcctcg ccccattggt actcgttacc tcacccgtaa tctgtaa        2217


<210> 5036
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5036
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys His Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ala Arg Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu 
    450                 455                 460                 


Gln Phe Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn 
465                 470                 475                 480 


Trp Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu 
                485                 490                 495     


Asp Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr 
            500                 505                 510         


His Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala 
        515                 520                 525             


Thr His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu 
    530                 535                 540                 


Ile Phe Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val 
545                 550                 555                 560 


Leu Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Glu Tyr Gly Thr Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala 
            580                 585                 590         


Ala Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5037
<211> 737
<212> PRT
<213> Adeno-associated virus

<400> 5037
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Lys Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Ser 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Thr Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5038
<211> 2214
<212> DNA
<213> Adeno-associated virus

<400> 5038
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctagaaag agactgaact ttgggcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggctg acaataacaa gggcgccgac      660

ggagtgggta atgcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggctttg cccacctaca acaaccacct ctacaagcaa      780

atctccagtc agtcagcagg tagcaccaac gacaacgtct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgtcacttct caccacgtga ctggcagcgg      900

ctcatcaaca gcaactgggg attccggccc aagaagctca acttcaagct gttcaacatc      960

caggtcaagg aggtcacaac gaatgacggc gtcacgacca tcgccaataa ccttaccagc     1020

acggttcagg tcttttcgga ctcggaatac cagctgccct acgtcctcgg ctccgcacac     1080

cagggctgcc tgcctccgtt cccggcggac gtcttcatga ttccccagta cggctacctg     1140

actctgaaca atggcagcca atcggtgggt cgttcctctt tctactgcct ggaatatttc     1200

ccttctcaaa tgctgagaac gggcaacaac ttcaccttca gctacacctt cgaggacgtt     1260

cccttccaca gcagctacgc acacagccag agcctggacc ggctgatgaa tcctcttatc     1320

gaccagtacc tgtattacct ggccagaaca cagagcaacg caggaggcac agctggcaat     1380

cgggaactgc agttttatca gggcgggcct accaccatgg ccgaacaagc caaaaactgg     1440

ctgcctggac cttgcttccg gcaacaaaga gtctccaaga cgctggatca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa taccatctaa atggaagaaa ttcattggtt     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccttcgagc     1620

ggagtcctga tttttggaaa aactggagca gctaataaga ctacactgga aaatgtgtta     1680

atgacaaatg aagaggaaat tcgtcctacc aacccggtag ccaccgagga atacgggact     1740

gttagcagca acctgcaggc ggctaacact gcagcccaga cacaagttgt caacaaccag     1800

ggagccttac ctggtatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga cggcaacttt cacccgtctc cgctgatggg cggctttgga     1920

ctgaagcatc cgcctcctca gatcctgatc aaaaacactc ctgttcctgc taatcccccg     1980

gaggtgttta cgcctgccaa gtttgcttct ttcatcacac agtacagcac cggccaggtc     2040

agcgtggaga tcgagtggga gctgcagaag gagaacagca agcgctggaa cccagagatt     2100

cagtatacct ccaattttga caaacagact ggtgtggact ttgccgttga cagccagggt     2160

gtttattctg agcctcgccc cattggtact cgttacctca cccgtaatct gtaa           2214


<210> 5039
<211> 737
<212> PRT
<213> Adeno-associated virus

<400> 5039
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Ser 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Thr Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5040
<211> 737
<212> PRT
<213> Adeno-associated virus

<400> 5040
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Thr Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5041
<211> 737
<212> PRT
<213> Adeno-associated virus

<400> 5041
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Lys Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Thr Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5042
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 5042
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgcac ctgcggtata atcacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acttatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacctcggg aggcagcacc aacgacaaca cctactttgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggag taccagctgc cgtacgtcct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcctca gtacggcaac     1140

ctgactctca acaacggtag tcaggccgtg ggacgttcct ccttctactg cctggagtac     1200

ttcccctctc agatgctgag aacgggcaac aacttttcct tcagctacac tttcgaggac     1260

gtgcctttcc acagcagcta cgcgcacagc cagagtttgg acaggctgat gaatcctctc     1320

atcgaccagt acctgtacta cctgtcaaga acccagtcta cgggaggcac agcgggaacc     1380

cagcagttgc tgttttctca ggccgggcct agcaacatgt cggctcaggc cagaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga acggcagaga ctctctggtg     1560

aatccgggcg tcgccatggc aaccaacaag gacgacgagg accgcttctt cccatccagc     1620

ggcatcctca tgtttggcaa gcagggagct ggaaaagaca acatgggcta tagcaacgtg     1680

atgctaacca gcgaggaaga aatcaagacc accaaccccg tggccacaga acagtatggc     1740

gtggtggctg ataacctaca gcagcaaaac accgctccta ttgtgggggc cgtcaacagc     1800

cagggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatt     1860

tgggccaaga ttcctcacac agatggcaac tttcacccgt ctcctttaat gggcggcttt     1920

ggacttaaac atccgcctcc tcagatcctc atcaaaaaca ctcctgttcc tgcggatcct     1980

ccaacagcgt tcaaccaggc caagctgaat tctttcatca cgcagtacgg caccggacaa     2040

gtcagcgtgg agatcgagtg ggagctgcag aaggagaaca gcaagcgctg gaacccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgtgg actttgctgt taatactgag     2160

ggtgtttact ctgagcctcg ccccattggc actcgttacc tcacccgtaa tctgtaa        2217


<210> 5043
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5043
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro His Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Leu Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Asn Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Met Gly Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Gly Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5044
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 5044
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccggaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacctcggg aggcagcacc aacgacaaca cctactttgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggaa taccagctgc cgtacgtcct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcctca gtacggctac     1140

ctgactctca acaacggtag tcaggccgtg ggacgttcct ccttctactg cctggagtac     1200

ttcccctctc agatgctgag aacgggcaac aacttttcct tcagctacac tttcgaggac     1260

gtgcctttcc acagcagcta cgcgcacagc cagagtttgg acaggctgat gaatcctctc     1320

gtcgaccagt acctgtacta cctgtcaaga acccagtcta cgggaggcac agcgggaacc     1380

cagcagttgc tgttttctca ggccgggcct agcaacatgt cggctcaggc cagaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga acggcagaga ctctctggtg     1560

aatccgggcg tcgccatggc aaccaacaag gacgacgagg accgcttctt cccatccagc     1620

ggcatcctca tgtttggcaa gcagggagct ggaaaagaca acgtggacta tagcaacgtg     1680

atgctaacca gcgaggaaga aatcaagacc accaaccccg tggccacaga acagtatggc     1740

gtggtggctg ataacctaca gcagcaaaac accgctccta ttgtgggggc cgtcaacagc     1800

cagggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatt     1860

tgggccaaga ttcctcacac agatggcaac tttcacccgt ctcctttaat gggcggcttt     1920

ggacttaaac atccgcctcc tcagatcctc atcaaaaaca ctcctgttcc tgcggatcct     1980

ccaacagcgt tcaaccaggc caagctgaat tctttcatca cgcagtacag caccggacaa     2040

gtcagcgtgg agatcgagtg ggagctgcag aaggagaaca gcaagcgctg gagcccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgtgg actttgctgt taatactgag     2160

ggtgtttact ctgagcctcg ccccattggc actcgttacc tcacccgtaa tctgtaa        2217


<210> 5045
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5045
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Gly Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Val Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Ser Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5046
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 5046
atggttgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcagggc      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctta aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagctt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgcg ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacctcggg aggcagcacc aacgacaaca cctactttgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggaa taccagctgc cgtacgtcct cggctctgcc     1080

caccagggct gccagcctcc gttcccggcg gacgtcttca tgattcctca gtacggctac     1140

ctgactctca acaacggtag tcaggccgtg ggacgttcct ccttctactg cctggagtac     1200

ttcccctctc agatgctgag aacgggcaac aacttttcct tcagctacac tttcgaggac     1260

gtgcctttcc acagcagcta cgcgcacagc cagagtttgg acaggctgat gaatcctctc     1320

atcgaccagt acctgtacta cctgtcaaga acccagtcta cgggaggcac agcgggaacc     1380

cagcagttgc tgttttctca ggccgggcct agcaacatgt cggctcaggc cagaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga acggcagaga ctctctggtg     1560

aatccgggcg tcgccatggc aaccaacaag gacgacgagg accgcttctt cccatccagc     1620

ggcatcctca tgtttggcaa gcagggagct ggaaaagaca acgtggacta tagcaacgtg     1680

atgctaacca gcgaggaaga aatcaagacc accaaccccg tggccacaga acagtatggc     1740

gtggtggctg ataacctaca gcagcaaaac accgctccta ttgtgggggc cgtcaacagc     1800

cagggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatt     1860

tgggccaaga ttcctcacac agatggcaac tttcacccgt ctcctttaat gggcggcttt     1920

ggacttaaac atccgcctcc tcagatcctc atcaaaaaca ctcctgttcc tgcggatcct     1980

ccaacagcgt tcaaccaggc caagctgaat tctttcatca cgcagtacag caccggacaa     2040

gtcagcgtgg agatcgagtg ggagccgcag aaggagaaca gcaagcgctg gaacccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgtgg actttgctgt taatactgag     2160

ggtgtttact ctgagcctcg ccccattggc actcgttacc tcacccgtaa tctgtaa        2217


<210> 5047
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5047
Met Val Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Gly Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Leu Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Gln Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Pro Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5048
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 5048
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacctcggg aggcagcacc aacgacaaca cctactttgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa tagcctcacc     1020

agcaccatcc aggtgtttac ggactcggaa taccagctgc cgtacgtcct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcctca gtacggctac     1140

ctgactccca acaacggtag tcaggccgtg ggacgttcct ccttctactg cctggagtac     1200

ttcccctctc agatgctgag aacgggcaac aacttttcct tcagctacac tttcgaggac     1260

gtgcctttcc acagcagcta cgcgcacagc cagagtttgg acaggctgat gaatcctctc     1320

atcgaccagt acctgtacta cctgtcaaga acccagtcta cgggaggcac agcgggaacc     1380

cagcagttgc tgtcttctca ggccgggcct agcaacatgt cggctcaggc cagaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga acggcagaga ctctctggtg     1560

aatccgggcg tcgccatggc aaccaacaag gacgacgagg accgcttctt cccatccagc     1620

ggcatcctca tgtttggcaa gcagggagct ggaaaagaca acgtggacta tagcaacgtg     1680

atgctaacca gcgaggaaga aatcaagacc accaaccccg tggccacaga acagtatggc     1740

gtggtggctg ataacctaca gcagcaaaac accgctccta ttgtgggggc cgtcaacagc     1800

cagggagcct tacctggcat ggtctggcag aaccgggacg tgtacttgca gggtcctatt     1860

tgggccaaga ttcctcacac agatggcaac tttcacccgt ctcctttaat gggcggcttt     1920

ggacttaaac atccgcctcc tcagatcctc atcaaaaaca ctcctgttcc tgcggatcct     1980

ccaacagcgt tcaaccaggc caagctgaat tctttcatca cgcagtacag caccggacaa     2040

gtcagcgtgg agatcgagtg ggagctgcag aaggagaaca gcaagcgctg gaacccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgtgg actttgctgt taatactgag     2160

ggtgtttact ctgagcctcg ccccattggc actcgttacc tcacccgtaa tctgtaa        2217


<210> 5049
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5049
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Ser Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Pro Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Ser Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5050
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5050
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Val His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Ser Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Pro Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5051
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 5051
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacctcggg aggcagcacc aacgacaaca cctactttgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggaa taccagctgc cgtacgtcct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcctca gtacggctac     1140

ctgactctca acaacggtag tcaggccgtg ggacgttcct ccttctactg cctggagtac     1200

ttcccctctc agatgctgag aacgggcaac aacttttcct tcagctacac tttcgaggac     1260

gtgcctttcc acagcagcta cgtgcacagc cagagtttgg acaggctgat gaatcctctc     1320

atcgaccagt acctgtacta cctgtcaaga acccagtcta cgggaggcac agcgggaacc     1380

cagcagttgc tgttttctca ggccgggcct agcaacatgt cggctcaggc cagaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga acggcagaga ctctctggtg     1560

aattcgggcg tcgccatggc aaccaacaag gacgacgagg accgcttctt cccatccagc     1620

ggcatcctca tgtttggcaa gcagggagct ggaaaagaca acgtggacta tagcaacgtg     1680

atgctaacca gcgaggaaga aatcaagacc accaaccccg tggccacaga acagtatggc     1740

gtggtggctg ataacctaca gcagcaaaac accgctccta ttgtgggggc cgtcaacagc     1800

cagggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatt     1860

tgggccaaga ttcctcacac agatggcaac tttcacccgt ctcctttaat gggcggcttt     1920

ggacttaaac atccgcctcc tcagatcctc atcaaaaaca ctcctgttcc tgcggatcct     1980

ccaacagcgt tcaaccaggc caagctgaat tctttcatca cgcagtacag caccggacaa     2040

gtcagcgtgg agatcgagtg ggagctgcag aaggagaaca gcaagcgctg gaacccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgtgg actttgctgt taatactgag     2160

ggtgtttact ctgagcctcg ccccattggc actcgttacc ccacccgtaa tctgtaa        2217


<210> 5052
<211> 734
<212> PRT
<213> Adeno-associated virus

<400> 5052
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Arg Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Thr Ala Ser Gly Thr Gln Gln Ser Arg Leu Leu Phe Ser Gln Ala 
    450                 455                 460                 


Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly Pro 
465                 470                 475                 480 


Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn Asn 
                485                 490                 495     


Ser Asn Phe Pro Trp Thr Gly Ala Thr Lys Tyr Tyr Leu Asn Gly Arg 
            500                 505                 510         


Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp Asp 
        515                 520                 525             


Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys Glu 
    530                 535                 540                 


Gly Thr Asn Ala Thr Asn Ala Glu Leu Glu Asn Val Met Ile Thr Asp 
545                 550                 555                 560 


Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly 
                565                 570                 575     


Tyr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Ala Ala Ser Thr Glu 
            580                 585                 590         


Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp Arg 
        595                 600                 605             


Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp 
    610                 615                 620                 


Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His 
625                 630                 635                 640 


Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn Pro 
                645                 650                 655     


Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr 
            660                 665                 670         


Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu 
        675                 680                 685             


Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Asn 
    690                 695                 700                 


Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr Ser 
705                 710                 715                 720 


Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 


<210> 5053
<211> 2214
<212> DNA
<213> Adeno-associated virus

<400> 5053
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctagaaag agactgaact ttgggcagac tggcgactca      540

gagtcagtcc ccgaccctca acctctcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta atgcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggctttg cccacctaca acaaccacct ctacaagcaa      780

atctccagtc agtcagcagg tagcaccaac gacaacgtct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgtcacttct caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggccc aagaagctca acttcaagct cttcaacatc      960

caagtcaagg aggtcacgac gaatgacggc gtcacgacca tcgctaataa ccttaccagc     1020

acggttcagg tcttttcgga ctcggagtac cagctgccgt acgtcctcgg ctctgcccac     1080

cagggctgcc tgcctccgtt cccggcggac gtcttcatga ttcctcagta cggctacctg     1140

actctgaaca atggcagcca atcggtggga cgttcatcct tctactgcct ggaatacttc     1200

ccttctcagg tgctgagaac gggtaacaac ttcaccttca gttacacctt cgaggacgtg     1260

cctttccaca gcagctacgc gcacagccag agcctagacc ggctgatgaa tcccctcatc     1320

gaccagtacc tgtattacct ggctagaaca cagagtaacc caggaggcac atctggcaat     1380

cgggaactgc agttttacca gggcgggcct tccaccatgg ccgaacaagc caagaactgg     1440

ttacctggac cttgcttccg gcaacaaaga gtttccaaaa cactggatca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa tatcacctga acggcagaaa ctcattggtg     1560

aatcctggtg tcgccatggc aactcacaag gacgacgagg accgcttttt cccatccagc     1620

ggagtcctga tttttggaaa aactggagca accaacaaga ctacattgga aaacgtgtta     1680

atgacaaatg aagaagaaat tcgtcctact aatcctgtgg ccacagaaga atacgggata     1740

gtcagcagca atttacaagc ggccaatact gcagcccaga cacaagttgt caacaaccag     1800

ggagccttac ctggcatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaaaattc ctcacacaga cggcaacttt cacccgtctc cgctgatggg cggctttgga     1920

ctgaagcatc cgcctcctca gatcctgatc aaaaacactc ctgttcctgc taatcccccg     1980

gaggtgttta cgcctgccaa gtttgcttct ttcatcacac agtacagcac cggccaggtc     2040

agcgtggaga tcgagtggga gctgcagaag gagaacagca agcgctggaa cccagagatt     2100

cagtatacct ccaattttga caaacagact ggtgtggact ttgccgttga cagccagggt     2160

gtttattctg agcctcgccc cattggtact cgttacctca cccgtaatct gtaa           2214


<210> 5054
<211> 737
<212> PRT
<213> Adeno-associated virus

<400> 5054
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Val Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Pro Gly Gly Thr Ser Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Ser Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Thr Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Ile Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5055
<211> 2214
<212> DNA
<213> Adeno-associated virus

<400> 5055
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca cacggctggg cgacagagtc      720

atcaccacca gcacccggac ctgggctttg cccacctaca acaaccacct ctacaagcaa      780

atctccagtc agtcagcagg tagcaccaac gacaacgtct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgtcacttct caccacgtga ctggcagcgg      900

ctcatcaaca acaactgggg attccggccc aagaagctca acttcaagct gttcaacatc      960

caggtcaagg aggtcacaac gaatgacggc gtcacgacca tcgccaataa ccttaccagc     1020

acggttcagg tcttttcgga ctcggaatac cagctgccct acgtcctcgg ctccgcacac     1080

cagggctgcc tgcctccgtt cccggcggac gtcttcatga ttccccagta cggctacctg     1140

actctgaaca atggcagcca atcggtgggt cgttcctctt tctactgcct ggaatatttc     1200

ccttctcaaa tgctgagaac gggcaacaac ttcaccttca gctacacctt cgaggacgtt     1260

cccttccaca gcagctacgc acacagccag agcctggacc ggctgatgaa tcctcttatc     1320

gaccagtacc tgtattacct ggccagaaca cagagcaacg caggaggcac agctggcaat     1380

cgggaactgc agttttatca gggcgggcct accaccatgg ccgaacaagc caaaaactgg     1440

ctgcctggac cttgcttccg gcaacgaaga gtctccaaga cgctggatca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa taccatctaa atggaagaaa ttcattggtt     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccttcgagc     1620

ggagtcctga tttttggaaa aactggagca gctaataaga ctacactgga aaatgtgtta     1680

atgacaaatg aagaggaaat tcgtcctacc aacccggtag ccaccgagga atacgggact     1740

gttagcagca acctgcaggc ggctaacact gcagcccaga cacaagttgt caacaaccag     1800

ggagccttac ctggtatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga cggcaacttt cacccgtctc cgctgatggg cggctttgga     1920

ctgaagcatc cgcctcctca gatcctgatc aaaaacactc ctgttcctgc taatcccccg     1980

gaggtgttta cgcctgccaa gtttgcttct ttcatcacac agtacagcac cggccaggtc     2040

agcgtggaga tcgagtggga gctgcagaag gagaacagca agcgctggaa cccagagatt     2100

cagtatacct ccaattttga caaacagact ggtgtggact ttgccgttga cagccagggt     2160

gtttattctg agcctcgccc cattggtact cgttacctca cccgtaatct gtaa           2214


<210> 5056
<211> 737
<212> PRT
<213> Adeno-associated virus

<400> 5056
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Arg Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Arg Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Thr Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5057
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 5057
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgtc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gcggagccag actcctcctc gggaaccgga      480

aaagcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tccgtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tttgggatct      600

actacaatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cttcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggcccagccc acctacaaca accacctcta caagcaaatc      780

tcaagccaat caggagcctc aaacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcgggtcggc gcatcaagga     1080

tgcctcccgc cgtttccagc ggacgtcttc atggtcccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcggt aggacgctct tccttttact gcctggagta ctttccttct     1200

cagatgcttc gtactggaaa caactttcag ttcagctaca cctttgaaga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gatcggctga tgaatcctct gatcgaccag     1320

tacctgtatt atctgaacaa aacacaatca aatagtggag ctcttcagca gtctcggcta     1380

ctgtttagtc aagctggacc caccagcatg tctcttcaag ctaaaaactg gctacctgga     1440

ccttgctaca gacagcagcg tctgtcaaag caggcaaacg acaacaacaa cagcaacttt     1500

ccctggactg cggctacaaa gtaccaccta aatggccggg actcgttggt taatccagga     1560

ccagctatgg ccagtcacaa agacgatgaa gaaaagtttt tccccatgca tggaaccctg     1620

atatttggta aacaaggaac aaatgctaac gacgcggatt tggacaatgt catgattaca     1680

gatgaagaag aaatccgcac caccaatccc gtggctacgg agcagtacgg atatgtgtca     1740

aataatttgc aaaactcaaa tactggtcca actactggaa ctgtcaatca ccgaggagcg     1800

ttacctggca tggtgtggca ggatcgagac gtgtacctgc agggacccat ttgggccaag     1860

attcctcaca ccgatggaca ctttcatcct tctccactga tgggaggttt tgggctcaaa     1920

cacccgcctc ctcagatcat gatcaaaaac actcccgttc cagccaatcc tcccacaaac     1980

ttcagttctg ccaagtttgc ttctttcatc acacagtatt ccacggggca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaagagaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaaatc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 5058
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 5058
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Gln Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Lys Thr 
        435                 440                 445             


Gln Ser Asn Ser Gly Ala Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Asp Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Tyr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Gly Thr Val Asn His Arg Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 5059
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 5059
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgcg ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

acctccaacg ggacctcggg aggcagcacc aacgacaaca cctactttgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggaa taccagctgc cgtacgtcct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcctca gtacggctac     1140

ctgactctca acaacggtag tcaggccgtg ggacgttcct ccttctactg cctggagtac     1200

ttcccctctc agatgctgag aacgggcaac aacttttcct tcagctacac tttcgaggac     1260

gtgcctttcc acagcagcta cgcgcacagc cagagtttgg acaggctgat gaatcctctc     1320

atcgaccagt acctgtacta cctgtcaaga acccagtcta cgggaggcac agcgggaacc     1380

cagcagttgc tgttttctca ggccgggcct agcaacatgt cggctcaggc cagaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga acggcagaga ctctctggtg     1560

aatccgggcg tcgccatggc aaccaacaag gacgacgagg accgcttctt cccatccagc     1620

ggcatcctca tgtttggcaa gcagggagct ggaaaagaca acgtggacta tagcaacgtg     1680

atgctaacca gcgaggaaga aatcaagacc accaaccccg tggccacaga acagtatggc     1740

gtggtggctg ataacctaca gcagcaaaac accgctccta ttgtgggggc cgtcaacagc     1800

cagggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatt     1860

tgggccaaga ttcctcacac agatggcaac tttcacccgt ctcctttaat gggcggcttt     1920

ggacttaaac atccgcctcc tcagatcctc atcaaaaaca ctcctgttcc tgcggatcct     1980

ccaacagcgt tcaaccaggc caagctgaat tctttcatca cgcagtacag caccggacaa     2040

gtcagcgcgg agatcgagtg ggagctgcag aaggagaaca gcaagcgctg gaacccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgtgg actttgctgt taatactgag     2160

ggtgtttact ctgagcctcg ccccattggc actcgttacc tcacccgtaa tctgtaa        2217


<210> 5060
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5060
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Thr Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Ala Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5061
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 5061
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctagaaag agactgaact ttgggcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggccgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacctcggg aggcagcacc aacgacaaca cctactttgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggaa taccagctgc cgtacgtcct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcctca gtacggctac     1140

ctgactctca acaacggtag tcaggccgtg ggacgttcct ccttctactg cctggagtac     1200

ttcccctctc agatgctgag aacgggcaac aacttttcct tcagctacac tttcgaggac     1260

gtgcctttcc acagcagcta cgcgcacagc cagagtttgg acaggctgat gaatcctctc     1320

atcgaccagt acctgtacta cctgtcaaga acccagtcta cgggaggcac agcgggaacc     1380

cagcagctgc tgttttctca ggccgggcct agcaacatgt cggctcaggc cagaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga acggcagaga ctctctggtg     1560

aatccgggcg tcgccatggc aaccaacaag gacgacgagg accgcttctt cccatccagc     1620

ggcatcctca tgtttggcaa gcagggagct ggaaaagaca acgtggacta tagcaacgtg     1680

atgctaacca gcgaggaaga aatcaagacc accaaccccg tggccacaga acagtatggc     1740

gtggtggctg ataacctaca gcagcaaaac accgctccta ttgtgggggc cgtcaacagc     1800

cagggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatt     1860

tgggccaaga ttcctcacac agatggcaac tttcacccgt ctcctttaat gggcggcttt     1920

ggacttaaac atccgcctcc tcagatcctc atcaaaagca ctcctgttcc tgcggatcct     1980

ccaacagcgt tcaaccaggc caagctgaat tctttcatca cgcagtacag caccggacaa     2040

gtcagcgtgg agatcgagtg ggagctgcag aaggagaaca gcaagtgctg gaacccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgtgg actttgctgt taatactgag     2160

ggtgtttact ctgagcctcg ccccattggc actcgttacc tcacccgtaa tctgtaa        2217


<210> 5062
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5062
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Ser Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Cys Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5063
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5063
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Ser Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5064
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 5064
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctagaaag agactgaact ttgggcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggctg acaataacga gggcgccgac      660

ggagtgggta atgcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggctttg cccacctaca acaaccacct ctacaagcaa      780

atctccagtc agtcagcagg tagcaccaac gacaacgtct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgtcacttct caccacgtga ctggcagcgg      900

ctcatcaaca acaactgggg attccggccc aagaagctca acttcaagct gttcaacatc      960

caggtcaagg aggtcacaac gaatgacggc gtcacgacca tcgccaataa ccctaccagc     1020

acggttcagg tcttttcgga ctcggaatac cagctgccct acgtcctcgg ctccgcacac     1080

cagggctgcc tgcctccgtt cccggcggac gtcttcatga ttccccagta cggctacctg     1140

actctgaaca atggcagcca atcggtgggt cgttcctctt tctactgcct ggaatatttc     1200

ccttctcaaa tgctgagaac gggcaacaac ttcaccttca gctacacctt cgaggacgtt     1260

cccttccaca gcagctacgc acacagccag agcctggacc ggctgatgaa tcctcttatc     1320

gaccagtacc tgtattacct ggccagaaca cagagcaacg caggaggcac agctggcaat     1380

cgggaactgc agttttatca gggcgggcct accaccatgg ccgaacaagc caaaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga acggcagaga ctctctggtg     1560

aatccgggcg tcgccatggc aaccaacaag gacgacgagg accgcttctt cccatccagc     1620

ggcatcctca tgtttggcaa gcagggagct ggaaaagaca acgtggacta tagcaacgtg     1680

atgctaacca gcgaggaaga aatcaagacc accaaccccg tggccacaga acagtatggc     1740

gtggtggctg ataacctaca gcagcaaaac accgctccta ttgtgggggc cgtcaacagc     1800

cagggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatt     1860

tgggccaaga ttcctcacac agatggcaac tttcacccgt ctcctttaat gggcggcttt     1920

ggacttaaac atccgcctcc tcagatcctc atcaaaaaca ctcctgttcc tgcggatcct     1980

ccaacagcgt tcaaccaggc caagctgaat tctttcatca cgcagtacag caccggacaa     2040

gtcagcgtgg agatcgagtg ggagctgcag aaggagaaca gcaagcgctg gaacccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgtgg actttgctgt taatactgag     2160

ggtgtttact ctgagcctcg ccccattggc actcgttacc tcacccgtaa tctgtaa        2217


<210> 5065
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5065
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Pro Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5066
<211> 2208
<212> DNA
<213> Adeno-associated virus

<400> 5066
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcac       60

gagtggtggg acccgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacccaca acaaccacct ctacaagcaa      780

atctccaacg ggacctcggg aggcagcacc aacgacaacg tctacttcgg ctacagcacc      840

ccctgggggt attttgactt caacagattc cactgtcact tctcaccacg tgaccggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggaa taccagctgc cgtacgtcct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcctca gtacggctac     1140

ctgactctca acaacggtag tcaggccgtg ggacgttcct ccttctactg cctggagtac     1200

ttcccctctc agatgctgag aacgggcaac aacttttcct tcagctacac tttcgaggac     1260

gtgcctttcc acagcagcta cgcgcacagc cagagtttgg acaggctgat gaatcctctc     1320

atcgaccagt acctgtacta cctgtcaaga acccagtcta cggaaggcac agcgggaacc     1380

cagcagttgc tgttttctca ggccgggcct agcaacatgt cggctcaggc cagaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga acggcagaga ctctctggtg     1560

aatccgggcg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccttcgagc     1620

ggagtcctga tttttggaaa aactggagca gctaataaga ctacactgga aaatgtgtta     1680

atgacaaatg aagaggaaat tcgtcctacc aacccggtag ccaccgagga atacgggact     1740

gttagcagca acctgcaggc ggctaacact gcagcccaga cacaagttgt caacaaccag     1800

ggagccttac ctggtatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga cggcaacttt cacccgtctc cgctgatggg cggctttgga     1920

ctgaagcatc ctcagatcct gatcaaaaac actcctgttc ctgctaatcc cccggaggtg     1980

tttacgcctg ccaagtttgc ttctttcatc acacagtaca gcaccggcca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggagaac agcaagcgct ggaacccaga gattcagtat     2100

acctccaatt ttgacaaaca gactggtgtg gactttgccg ttgacagcca gggtgtttat     2160

tctgagcctc gccccattgg tactcgttac ctcacccgta atctgtaa                  2208


<210> 5067
<211> 735
<212> PRT
<213> Adeno-associated virus

<400> 5067
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile His Glu Trp Trp Asp Pro Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr His Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Arg Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Glu Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Thr Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Phe 
    690                 695                 700                 


Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 5068
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5068
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Pro Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Pro Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asp Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Val Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5069
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 5069
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaagg ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacctcggg aggcagcacc aacgacaaca cctactttgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgacccatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggaa taccagctgc cgtacgtcct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcctca gtacggctac     1140

ctgactctca acaacggtag tcaggccgtg ggacgttcct ccttctactg cctggagtac     1200

ttcccctctc agatgctgag aacgggcaac aacttttcct tcagctaccc tttcgaggac     1260

gtgcctttcc acagcagcta cgcgcacagc cagagtttgg acaggctgat gaatcctctc     1320

atcgaccagt acctgtacta cctgtcaaga acccagtcta cgggaggcac agcgggaacc     1380

cagcagttgc tgttttctca ggccgggcct agcaacatgt cggctcaggc cagaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga acggcagaga ctctctggtg     1560

aatccgggcg tcgccatggc aaccaacaag gacgacgagg accgcttctt cccatccagc     1620

ggcatcctca tgtttggcaa gcagggagct ggaaaagaca acgtggacta tagcaacgtg     1680

atgctaacca gcgaggaaga aatcaagacc accaaccccg tggccacaga acagtatggc     1740

gtggtggctg ataacctaca gcagcaagac accgctccta ttgtgggggc cgtcaacagc     1800

cagggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatt     1860

tgggccaaga ttcctcacac agatggcaac tttcacccgt ctcctttaat gggcggcttt     1920

ggacttaaac atccgcctcc tcaggtcctc atcaaaaaca ctcctgttcc tgcggatcct     1980

ccaacagcgt tcaaccaggc caagctgaat tctttcatca cgcagtacag caccggacaa     2040

gtcagcgtgg agatcgagtg ggagctgcag aaggagaaca gcaagcgctg gaacccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgtgg actttgctgt taatactgag     2160

ggtgtttact ctgagcctcg ccccattggc actcgttacc tcacccgtaa tctgtaa        2217


<210> 5070
<211> 2214
<212> DNA
<213> Adeno-associated virus

<400> 5070
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttc      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggctgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctagaaag agactgaact ttgggcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gagccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggctg acaataacaa gggcgccgac      660

ggagtgggta atgcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggctttg cccacctaca acaaccacct ctacaagcaa      780

atctccagtc agtcagcagg tagcaccaac gacaacgtct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgtcacttct caccacgtga ctggcagcgg      900

ctcatcaaca acaactgggg attccggccc aagaagctca acttcaagct gttcaacatc      960

caggtcaagg aggtcacaac gggtgacggc gtcacgacca tcgccaataa ccttaccagc     1020

acggttcagg tcttttcgga ctcggaatac cagctgccct acgtcctcgg ctccgcacac     1080

cagggctgcc tgcctccgtt cccggcggac gtcttcatga ttccccagta cggctacctg     1140

actctgaaca atgacagcca atcggtgggt cgttcctctt tctactgcct ggaatatttc     1200

ccttctcaaa tgctgagaac gggcaacaac ttcaccttca gctacacctt cgaggacgtt     1260

cccttccaca gcagctacgc acacagccag agcctggacc ggctgatgaa tcctcttatc     1320

gaccagtacc tgtattacct ggccagaaca cagagcaacg caggaggcac agctggcaat     1380

cgggaactgc agttttatca gggcgggcct accaccatgg ccgaacaagc caaaaactgg     1440

ctgcctggac cttgcttccg gcaacaaaga gtctccaaga cgctggatca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa taccatctaa atggaagaaa ttcattggtt     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccttcgagc     1620

ggagtcctga tttttggaaa aactggagca gctaataaga ctacactgga aaatgtgtta     1680

atgacaaatg aagaggaaat tcgtcctacc aacccggtag ccaccgagga atacgggact     1740

gttagcagca acctgcaggc ggctaacact gcagcccaga cacaagttgt caacaaccag     1800

ggagccttac ctggtatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga cggcaacttt cacccgtctc cgctgatggg cggctttgga     1920

ctgaagcatc cgcctcctca gatcctgatc aaaaacactc ctgttcctgc taatcccccg     1980

gaggtgttta cgcctgccaa gtttgcttct ttcatcacac agtacagcac cggccaggtc     2040

agcgtggaga tcgagtggga gctgcagaag gagaacagca agcgctggaa cccagagatt     2100

cagtatacct ccaattttga caaacagact ggtgtggact ttgccgttga cagccagggt     2160

gtttattctg agcctcgccc cattggtact cgttacctca cccgtaatct gtaa           2214


<210> 5071
<211> 737
<212> PRT
<213> Adeno-associated virus

<400> 5071
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Ala Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Lys Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Gly Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Asp Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Thr Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5072
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 5072
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacctcggg aggcagcacc aacgacaaca cctactttgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggaa taccagctgc cgtacgtcct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcctca gtacggctac     1140

ctgactctca acaacggtag tcaggccgtg ggacgttcct ccttctactg cctggagtac     1200

ttcccctctc agatgctgag aacgggcaac aacttttcct tcagctacac tttcgaggac     1260

gtgcctttcc acagcagcta cgcgcacagc cagagtttgg acaggctgat gaatcctctc     1320

atcgaccagt acctgtacta cctgtcaaga acccagtcta cgggaggcac agcgggaacc     1380

cagcagttgc tgttttctca ggccgggcct agcaacatgt cggctcaggc cagaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga acggcagaga ctctctggtg     1560

aatccgggcg tcgccatggc aaccaacaag gacgacgagg accgcttctt cccatccagc     1620

ggcatcctca tgtttggcaa gcagggagct ggaaaagaca acgtggacta tagcaacgtg     1680

atgctaacca gcgaggaaga aatcaagacc accaaccccg tggccacaga acagtatggc     1740

gtggtggctg ataacctaca gcagcaaaac accgctccta ttgtgggggc cgtcaacagc     1800

cagggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatt     1860

tgggccaaga ttcctcacac agatggcaac tttcacccgt ctcctttaat gggcggcttt     1920

ggacttaaac atccgcctcc tcagatcctc atcaaaaaca ctcctgttcc tgcggatcct     1980

ccaacagcgt tcaaccaggc caagctgaat tctttcatca cgcagtacag caccggacaa     2040

gtcagcgtgg agatcgtgtg ggagctgcag aaggagaaca gcaagcgcag gaacccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgtgg actttgctgt taatactgag     2160

ggtgtttact ctgagcctcg ccccattggc actcgttacc tcacccgtaa tctgtaa        2217


<210> 5073
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5073
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Val Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Arg Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5074
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5074
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5075
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5075
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Val Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5076
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5076
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5077
<211> 2214
<212> DNA
<213> Adeno-associated virus

<400> 5077
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctagaaag agactgaact ttgggcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta atgcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggctttg cccacctaca acaaccacct ctacaagcaa      780

atctccagtc agtcagcagg tagcaccaac gacaacgtct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgtcacttct caccacgtga ctggcagcgg      900

ctcatcaaca acaactgggg attccggccc aagaagctca acttcaagct gttcaacatc      960

caggtcaagg aggtcacaac gaatgacggc gtcacgacca tcgccaataa ccttaccagc     1020

acggttcagg tcttttcgga ctcggaatac cagctgccct acgtcctcgg ctccgcacac     1080

cagggctgcc tgcctccgtt cccggcggac gtcttcatga ttccccagta cggctacctg     1140

actctgaaca atggcagcca atcggtgggt cgttcctctt tctactgcct ggaatatttc     1200

ccttctcaaa tgctgagaac gggcaacaac ttcaccttca gctacacctt cgaggacgtt     1260

cccttccaca gcagctacgc acacagccag agcctggacc ggctgatgaa tcctcttatc     1320

gaccagtacc tgtattacct ggccagaaca cagagcaacg caggaggcac agctggcaat     1380

cgggaactgc agttttatca gggcgggcct accaccatgg ccgaacaagc caaaaactgg     1440

ctgcctagac cttgcttccg gcaacaaaga gtctccaaga cgctggatca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa taccatctaa atggaagaaa ttcattggtt     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccttcgagc     1620

ggagtcctga tttttggaaa aactggagca gctaataaga ctacactgga aaatgtgtta     1680

atgacaaatg aagaggaaat tcgtcctacc aacccggtag ccaccgagga atacgggact     1740

gttagcagca acctgcaggc ggctaacact gcagcccaga cacaagttgt caacaaccag     1800

ggagccttac ctggtatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga cggcaacttt cacccgtctc cgctgatggg cggctttgga     1920

ctgaagcatc cgcctcctca gatcctgatc aaaaacactc ctgttcctgc taatcccccg     1980

gaggtgttta cgcctgccaa gtttgcttct ttcatcacac agtacagcac cggccaggtc     2040

agcgtggaga tcgagtggga gctgcagaag gagaacagca agcgctggaa cccagagatt     2100

cagtatacct ccaattttga caaacagact ggtgtggact ttgccgttga cagccagggt     2160

gtttattctg agcctcgccc cattggtact cgttacctca cccgtaatct gtaa           2214


<210> 5078
<211> 737
<212> PRT
<213> Adeno-associated virus

<400> 5078
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Arg Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Thr Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5079
<211> 2214
<212> DNA
<213> Adeno-associated virus

<400> 5079
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accatgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcctccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctagaaag agactgaact ttgggcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta atgcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggctttg cccacctaca acaaccacct ctacaagcaa      780

atctccagtc agtcagcagg tagcaccaac gacaacgtct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgtcacttct caccacgtga ctggcagcgg      900

ctcatcaaca acaactgggg attccggccc aagaagctca acttcaagct gttcaacatc      960

caggtcaagg aggtcacaac gaatgacggc gtcacgacca tcgccaataa ccttaccagc     1020

acggttcagg tcttttcgga ctcggaatac cagctgccct acgtcctcgg ctccgcacac     1080

cagggctgcc tgcctccgtt cccggcggac gtcttcatga ttccccagta cggctacctg     1140

actctgaaca atggcagcca atcggtgggt cgttcctctt tctactgcct ggaatatttc     1200

ccttctcaaa tgctgagaac gggcaacaac ttcaccttca gctacacctt cgaggacgtt     1260

cccttccaca gcagctacgc acacagccag agcctggacc ggctgatgaa tcctcttatc     1320

gaccagtacc tgtattacct ggccagaaca cagagcaacg caggaggcac agctggcaat     1380

cgggaactgc agttttatca gggcgggcct accaccatgg ccgaacaagc caaaaactgg     1440

ctgcctggac cttgcttccg gcaacaaaga gtctccaaga cgctggatca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa taccatctaa atggaagaaa ttcattggtt     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccttcgagc     1620

ggagtcctga tttttggaaa aactggagca gctaataaga ctacactgga aaatgtgtta     1680

atgacaaatg aagaggaaat tcgtcctacc aacccggtag ccaccgagga atacgggact     1740

gttagcagca acctgcaggc ggctaacact gcagcccaga cacaagttgt caacaaccag     1800

ggagccttac ctggtatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga cggcaacttt cacccgtctc cgctgatggg cggctttgga     1920

ctgaagcatc cgcctcctca gatcctgatc aaaaacactc ctgttcctgc taatcccccg     1980

gaggtgttta cgcctgccaa gtttgcttct ttcatcacac agtacagcac cggccaggtc     2040

agcgtggaga tcgagtggga gctgcagaag gagaacagca agcgctggaa cccagagatt     2100

cagtatacct ccaattttga caaacagact ggtgtggact ttgccgttga cagccagggt     2160

gtttattctg agcctcgccc cattggtact cgttacctca cccgtaatct gtaa           2214


<210> 5080
<211> 737
<212> PRT
<213> Adeno-associated virus

<400> 5080
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Thr Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5081
<211> 737
<212> PRT
<213> Adeno-associated virus

<400> 5081
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Leu Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Thr Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Asp Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5082
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 5082
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacctcggg aggcagcacc aacgacaaca cctactttgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggaa taccagctgc cgtacgtcct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcctca gtacggctac     1140

ctgactctca acaacggtag tcaggccgtg ggacgttcct ccttctactg cctggagtac     1200

ttcccctctc agatgctgag aacgggcaac aacttttcct tcagctacac tttcgaggac     1260

gtgcctttcc acagcagcta cgcgcacagc cagagtttgg acaggctgat gaatcctctc     1320

atcgaccagt acctgtacta cctgtcaaga acccagtcta cgggaggcac agcgggaacc     1380

cagcagttgc tgttttctca ggccgggcct agcaacatgt cggctcaggc cagaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga acggcagaga ctctctggtg     1560

aatccgggcg tcgccatggc aaccaacaag gacgacgagg accgcttctt cccacccagc     1620

ggcatcctca tgtttggcaa gcagggagct ggaaaagaca acgtggacta tagcaacgtg     1680

atgctaacca gcgaggaaga aatcaagacc accaaccccg tggccacaga acagtatggc     1740

gtggtggctg ataacctaca gcagcaaaac accgctccta ttgtgggggc cgtcaacagc     1800

cagggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatt     1860

tgggccaaga ttcctcacac agatggcaac tttcacccgt ctcctttaat gggcggcttt     1920

ggacttaaac atccgcctcc tcagatcctc atcaaaaaca ctcctgttcc tgcggatcct     1980

ccaacagcgt tcaaccaggc caagctgaat tctttcatca cgcagtacag caccggacaa     2040

gtcagcgtgg tgatcgagtg ggagctgcag aaggagaaca gcaagcgctg gaacccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgtgg actttgctgt taatactgag     2160

ggtgtttact ctgagcttcg ccccattggc actcgttacc tcacccgtaa tctgtaa        2217


<210> 5083
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5083
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Pro Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Val Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Leu Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5084
<211> 2214
<212> DNA
<213> Adeno-associated virus

<400> 5084
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctagaaag agactgaact ttgggcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgcc ccaatggcag acaataacga aggcgccgac      660

ggagtgggta atgcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggctttg cccacctaca acaaccacct ctacaagcaa      780

atctccagtc agtcagcagg tagcaccaac gacaacgtct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgtcacttct caccacgtga ctggcagcgg      900

ctcatcaaca acaactgggg attccggccc aagaagctca acttcaagct gttcaacatc      960

caggtcaagg aggtcacaac gaatgacggc gtcacgacca tcgccaataa ccttaccagc     1020

acggttcagg tcttttcgga ctcggaatac cagctgccct acgtcctcgg ctccgcacac     1080

cagggctgcc tgcctccgtt cccggcggac gtcttcatga ttccccagta cggctacctg     1140

actctgaaca atggcagcca atcggtgggt cgttcctctt tctactgcct ggaatatttc     1200

ccttctcaaa tgctgagaac gggcaacaac ttcaccatca gctacacctt cgaggacgtt     1260

cccttccaca gcagctacgc acacagccag agcctggacc ggctgatgaa tcctcttatc     1320

gaccagtacc tgtattacct ggccagaaca cagagcaacg caggaggcac agctggcaat     1380

caggaactgc agttttatca gggcgggcct accaccatgg ccgaacaagc caaaaactgg     1440

ctgcctggac cttgcttccg gcaacaaaga gtctccaaga cgctggatca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa taccatctaa atggaagaaa ttcattggtt     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccttcgagc     1620

ggagtcctga tttttggaaa aactggagca gctaataaga ctacactgga aaatgtgtta     1680

atgacaaatg aagaggaaat tcgtcctacc aacccggtag ccaccgagga atacgggact     1740

gttagcagca acctgcaggc ggctaacact gcagcccaga cacaagttgt caacaaccag     1800

ggagccttac ctggtatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacaga tggcaacttt cacccgtctc ctttaatggg cggctttgga     1920

cttaaacatc cgcctcctca gatcctcatc aaaaacactc ctgttcctgc ggatcctcca     1980

acagcgttca accaggccaa gctgaattct ttcatcacgc agtacagcac cggacaagtc     2040

agcgtggaga tcgagtggga gctgcagaag gagaacagca agcgctggaa cccagagatt     2100

cagtatactt ccaactacta caaatctaca aatgtggact ttgctgttaa tactgagggt     2160

gtttactctg agcctcgccc cattggcact cgttacctca cccgtaatct gtaa           2214


<210> 5085
<211> 737
<212> PRT
<213> Adeno-associated virus

<400> 5085
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Val Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Ile Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Ala Gly Gly Thr Ala Gly Asn Gln Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Thr Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Ala Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Thr Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5086
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 5086
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccgtcacca cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctatcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccgcctaca acaaccacct ctacaagcaa      780

atctccaacg ggacctcggg aggcagcacc aacgacaaca cctactttgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aagaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggaa taccagctgc cgtacgtcct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gatgtcttca tgattcctca gtacggctac     1140

ctgactctca acaacggtag tcaggccgtg ggacgttcct ccttctactg cctggagtac     1200

ttcccctctc agatgctgag aacgggcaac aacttttcct tcagctacac tttcgaggac     1260

gtgcctttcc acagcagcta cgcgcacagc cagagtttgg acaggctgat gaatcctctc     1320

atcgaccagt acctgtacta cctgtcaaga acccagtcta cgggaggcac agcgggaacc     1380

cagcagttgc tgttttctca ggccgggcct agcaacatgt cggctcaggc cagaaactgg     1440

ctgcctggac cctgctacag acagcagcgc gtctccacga cactgtcgca aaacaacaac     1500

agcaactttg cctggactgg tgccaccaag tatcatctga gcggcagaga ctctctggtg     1560

aatccgggcg tcgccatggc aaccaacaag gacgacgagg accgcttctt cccatccagc     1620

ggcatcctca tgtttggcaa gcagggagct ggaaaagaca acgtggacta tagcaacgtg     1680

atgctaacca gcgaggaaga aatcaagacc accaaccccg tggccacaga acagtatggc     1740

gtggtggctg ataacctaca gcagcaaaac accgctccta ttgtgggggc cgtcaacagc     1800

cagggagcct tacctggcat ggtctggcag aaccgggacg tgtacctgca gggtcctatt     1860

tgggccaaga ttcctcacac agatggcaac tttcacccgt ctcctttaat gggcggcttt     1920

ggacttaaac atccgcctcc tcagatcctc atcaaaaaca ctcctgttcc tgcggatcct     1980

ccaacagcgt tcaaccaggc caagctgaat tcttccatca cgcagtacag caccggacaa     2040

gtcagcgtgg agatcgagtg ggagctgcag aaggagaaca gcaagcgctg gaacccagag     2100

attcagtata cttccaacta ctacaaatct acaaatgtgg actttgctgt taatactgag     2160

ggtgtttact ctgagcctcg ccccattggc actcgttacc tcacccgtaa tttgtaa        2217


<210> 5087
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5087
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Ala Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Ser Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Ser 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5088
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 5088
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5089
<211> 2217
<212> DNA
<213> Adeno-associated virus

<400> 5089
atggctgctg acggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccc aagcccaagg ccaaccagca gaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aagctgctaa gacggctcct      420

ggaaagaaga gaccggtaga accgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgctaaaaag agactgaact ttggtcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atatccaatg ggacatcggg aggaagcacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt caacagattc cactgccact tctcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg ccaaaaagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taaccttacc     1020

agcacgattc aggtatttac ggactcggaa taccagctgc cgtacgtcct cggctccgcg     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcccca gtacggctac     1140

cttacactga acaatggaag tcaagccgta ggccgttcct ccttctactg cctggaatat     1200

tttccatctc aaatgctgcg aactggaaac aattttgaat tcagctacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcacacagc cagagcttgg accgactgat gaatcctctc     1320

atcgaccagt acctgtacta cttatccaga actcagtcca caggaggaac tcaaggtacc     1380

cagcaattgt tattttctca agctgggcct gcaaacatgt cggctcaggc taagaactgg     1440

ctacctggac cttgctaccg gcagcagcga gtctctacga cactgtcgca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa tatcacctga acggaagaga ctctttggta     1560

aatcccggtg tcgccatggc aacccacaag gacgacgagg aacgcttctt cccgtcgagt     1620

ggagtcctga tgtttggaaa acagggtgct ggaagagaca atgtggacta cagcagcgtt     1680

atgctaacca gcgaagaaga aattaaaacc actaaccctg tagccacaga acaatacggt     1740

gtggtggctg acaacttgca gcaaaccaat acagggccta ttgtgggaaa tgtcaacagc     1800

caaggagcct tacctggcat ggtctggcag aaccgagacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccaccctt caccgctaat gggaggattt     1920

ggactgaagc acccacctcc tcagatcctg atcaagaaca cgccggtacc tgcggatcct     1980

ccaacaacgt tcagccaggc gaaattggct tccttcatta cgcagtacag caccggacag     2040

gtcagcgtgg aaatcgagtg ggagctgcag aaggagaaca gcaaacgctg gaacccagag     2100

attcagtaca cttcaaacta ctacaaatct acaaatgtgg actttgctgt caatacagag     2160

ggaacttatt ctgagcctcg ccccattggt actcgttacc tcacccgtaa tctgtaa        2217


<210> 5090
<211> 738
<212> PRT
<213> Adeno-associated virus

<400> 5090
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Arg Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5091
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 5091
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Leu Asn Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Asp Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Gly 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Lys Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Thr Pro Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Ser Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Ser Pro His Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Glu Ala Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ser Asp Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Thr Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys 
        435                 440                 445             


Thr Gln Gly Thr Asn Ala Thr Val Gln Gly Ala Lys Leu Gln Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Ser Asn Met Arg Asp Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Glu Tyr Ala Trp Thr Gly Ala Thr Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met Asn Gly Thr Leu Val Phe Gly 
    530                 535                 540                 


Lys Asn Gly Ala Gly Asn Ser Asn Val Asp Ile Glu Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Val Val Ser Asp Asn Leu Gln Ser Ser Asn Thr Arg Pro Ile 
            580                 585                 590         


Thr Gly Asp Val Asp Ser Gln Gly Val Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Ala Thr Thr Phe Thr Pro Gly Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Gln Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 5092
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 5092
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Pro Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Leu Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Val 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Thr Gly Gly Thr Gln Thr Leu Ala Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Ser Ser Met Ala Asn Gln Ala Arg Asn Trp Val Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Asn Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Ala Lys Phe Lys Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Met Asn Pro Gly Val Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Asp Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Ala Gly Asn Asp Gly Val Asp Tyr Ser Gln Val Leu Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ala Val Ala Ile Asn Asn Gln Ala Ala Asn Thr Gln Ala Gln 
            580                 585                 590         


Thr Gly Leu Val His Asn Gln Gly Val Ile Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Leu Thr Phe Asn Gln Ala Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 5093
<211> 736
<212> PRT
<213> Adeno-associated virus

<400> 5093
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Pro Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Leu Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Val 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Thr Gly Gly Thr Gln Thr Leu Ala Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Ser Ser Met Ala Asn Gln Ala Arg Asn Trp Val Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Asn Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Ala Lys Phe Lys Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Met Asn Pro Gly Val Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Ala Gly Asn Asp Gly Val Asp Tyr Ser Gln Val Leu Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ala Val Ala Ile Asn Asn Gln Ala Ala Asn Thr Gln Ala Gln 
            580                 585                 590         


Thr Gly Leu Val His Asn Gln Gly Val Ile Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Leu Thr Phe Asn Gln Ala Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 5094
<211> 2211
<212> DNA
<213> Adeno-associated virus 1

<400> 5094
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcatcggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg atccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgcacctg ggccttgccc acctacaata accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc cacttttcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaaactctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acaaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag cttccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcaatacgg ctacctgacg     1140

ctcaacaatg gcagccaagc cgtgggacgt tcatcctttt actgcctgga atatttccct     1200

tctcagatgc tgagaacggg caacaacttt accttcagct acacctttga ggaagtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

caatacctgt attacctgaa cagaactcaa aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgtgggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaat     1500

tttacctgga ctggtgcttc aaaatataac ctcaatgggc gtgaatccat catcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaagagag cgccggagct tcaaacactg cattggacaa tgtcatgatt     1680

acagacgaag aggaaattaa agccactaac cctgtggcca ccgaaagatt tgggaccgtg     1740

gcagtcaatt tccagagcag cagcacagac cctgcgaccg gagatgtgca tgctatggga     1800

gcattacctg gcatggtgtg gcaagataga gacgtgtacc tgcagggtcc catttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccaat actccacagg acaagtgagt     2040

gtggaaattg aatgggagct gcagaaagaa aacagcaagc gctggaatcc cgaagtgcag     2100

tacacatcca attatgcaaa atctgccaac gttgatttta ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt taccttaccc gtcccctgta a              2211


<210> 5095
<211> 736
<212> PRT
<213> Adeno-associated virus 1

<400> 5095
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5096
<211> 4718
<212> DNA
<213> Adeno-associated virus 1

<400> 5096
ttgcccactc cctctctgcg cgctcgctcg ctcggtgggg cctgcggacc aaaggtccgc       60

agacggcaga gctctgctct gccggcccca ccgagcgagc gagcgcgcag agagggagtg      120

ggcaactcca tcactagggg taatcgcgaa gcgcctccca cgctgccgcg tcagcgctga      180

cgtaaattac gtcatagggg agtggtcctg tattagctgt cacgtgagtg cttttgcgac      240

attttgcgac accacgtggc catttagggt atatatggcc gagtgagcga gcaggatctc      300

cattttgacc gcgaaatttg aacgagcagc agccatgccg ggcttctacg agatcgtgat      360

caaggtgccg agcgacctgg acgagcacct gccgggcatt tctgactcgt ttgtgagctg      420

ggtggccgag aaggaatggg agctgccccc ggattctgac atggatctga atctgattga      480

gcaggcaccc ctgaccgtgg ccgagaagct gcagcgcgac ttcctggtcc aatggcgccg      540

cgtgagtaag gccccggagg ccctcttctt tgttcagttc gagaagggcg agtcctactt      600

ccacctccat attctggtgg agaccacggg ggtcaaatcc atggtgctgg gccgcttcct      660

gagtcagatt agggacaagc tggtgcagac catctaccgc gggatcgagc cgaccctgcc      720

caactggttc gcggtgacca agacgcgtaa tggcgccgga ggggggaaca aggtggtgga      780

cgagtgctac atccccaact acctcctgcc caagactcag cccgagctgc agtgggcgtg      840

gactaacatg gaggagtata taagcgcctg tttgaacctg gccgagcgca aacggctcgt      900

ggcgcagcac ctgacccacg tcagccagac ccaggagcag aacaaggaga atctgaaccc      960

caattctgac gcgcctgtca tccggtcaaa aacctccgcg cgctacatgg agctggtcgg     1020

gtggctggtg gaccggggca tcacctccga gaagcagtgg atccaggagg accaggcctc     1080

gtacatctcc ttcaacgccg cttccaactc gcggtcccag atcaaggccg ctctggacaa     1140

tgccggcaag atcatggcgc tgaccaaatc cgcgcccgac tacctggtag gccccgctcc     1200

gcccgcggac attaaaacca accgcatcta ccgcatcctg gagctgaacg gctacgaacc     1260

tgcctacgcc ggctccgtct ttctcggctg ggcccagaaa aggttcggga agcgcaacac     1320

catctggctg tttgggccgg ccaccacggg caagaccaac atcgcggaag ccatcgccca     1380

cgccgtgccc ttctacggct gcgtcaactg gaccaatgag aactttccct tcaatgattg     1440

cgtcgacaag atggtgatct ggtgggagga gggcaagatg acggccaagg tcgtggagtc     1500

cgccaaggcc attctcggcg gcagcaaggt gcgcgtggac caaaagtgca agtcgtccgc     1560

ccagatcgac cccacccccg tgatcgtcac ctccaacacc aacatgtgcg ccgtgattga     1620

cgggaacagc accaccttcg agcaccagca gccgttgcag gaccggatgt tcaaatttga     1680

actcacccgc cgtctggagc atgactttgg caaggtgaca aagcaggaag tcaaagagtt     1740

cttccgctgg gcgcaggatc acgtgaccga ggtggcgcat gagttctacg tcagaaaggg     1800

tggagccaac aaaagacccg cccccgatga cgcggataaa agcgagccca agcgggcctg     1860

cccctcagtc gcggatccat cgacgtcaga cgcggaagga gctccggtgg actttgccga     1920

caggtaccaa aacaaatgtt ctcgtcacgc gggcatgctt cagatgctgt ttccctgcaa     1980

gacatgcgag agaatgaatc agaatttcaa catttgcttc acgcacggga cgagagactg     2040

ttcagagtgc ttccccggcg tgtcagaatc tcaaccggtc gtcagaaaga ggacgtatcg     2100

gaaactctgt gccattcatc atctgctggg gcgggctccc gagattgctt gctcggcctg     2160

cgatctggtc aacgtggacc tggatgactg tgtttctgag caataaatga cttaaaccag     2220

gtatggctgc cgatggttat cttccagatt ggctcgagga caacctctct gagggcattc     2280

gcgagtggtg ggacttgaaa cctggagccc cgaagcccaa agccaaccag caaaagcagg     2340

acgacggccg gggtctggtg cttcctggct acaagtacct cggacccttc aacggactcg     2400

acaaggggga gcccgtcaac gcggcggacg cagcggccct cgagcacgac aaggcctacg     2460

accagcagct caaagcgggt gacaatccgt acctgcggta taaccacgcc gacgccgagt     2520

ttcaggagcg tctgcaagaa gatacgtctt ttgggggcaa cctcgggcga gcagtcttcc     2580

aggccaagaa gcgggttctc gaacctctcg gtctggttga ggaaggcgct aagacggctc     2640

ctggaaagaa acgtccggta gagcagtcgc cacaagagcc agactcctcc tcgggcatcg     2700

gcaagacagg ccagcagccc gctaaaaaga gactcaattt tggtcagact ggcgactcag     2760

agtcagtccc cgatccacaa cctctcggag aacctccagc aacccccgct gctgtgggac     2820

ctactacaat ggcttcaggc ggtggcgcac caatggcaga caataacgaa ggcgccgacg     2880

gagtgggtaa tgcctcagga aattggcatt gcgattccac atggctgggc gacagagtca     2940

tcaccaccag cacccgcacc tgggccttgc ccacctacaa taaccacctc tacaagcaaa     3000

tctccagtgc ttcaacgggg gccagcaacg acaaccacta cttcggctac agcaccccct     3060

gggggtattt tgatttcaac agattccact gccacttttc accacgtgac tggcagcgac     3120

tcatcaacaa caattgggga ttccggccca agagactcaa cttcaaactc ttcaacatcc     3180

aagtcaagga ggtcacgacg aatgatggcg tcacaaccat cgctaataac cttaccagca     3240

cggttcaagt cttctcggac tcggagtacc agcttccgta cgtcctcggc tctgcgcacc     3300

agggctgcct ccctccgttc ccggcggacg tgttcatgat tccgcaatac ggctacctga     3360

cgctcaacaa tggcagccaa gccgtgggac gttcatcctt ttactgcctg gaatatttcc     3420

cttctcagat gctgagaacg ggcaacaact ttaccttcag ctacaccttt gaggaagtgc     3480

ctttccacag cagctacgcg cacagccaga gcctggaccg gctgatgaat cctctcatcg     3540

accaatacct gtattacctg aacagaactc aaaatcagtc cggaagtgcc caaaacaagg     3600

acttgctgtt tagccgtggg tctccagctg gcatgtctgt tcagcccaaa aactggctac     3660

ctggaccctg ttatcggcag cagcgcgttt ctaaaacaaa aacagacaac aacaacagca     3720

attttacctg gactggtgct tcaaaatata acctcaatgg gcgtgaatcc atcatcaacc     3780

ctggcactgc tatggcctca cacaaagacg acgaagacaa gttctttccc atgagcggtg     3840

tcatgatttt tggaaaagag agcgccggag cttcaaacac tgcattggac aatgtcatga     3900

ttacagacga agaggaaatt aaagccacta accctgtggc caccgaaaga tttgggaccg     3960

tggcagtcaa tttccagagc agcagcacag accctgcgac cggagatgtg catgctatgg     4020

gagcattacc tggcatggtg tggcaagata gagacgtgta cctgcagggt cccatttggg     4080

ccaaaattcc tcacacagat ggacactttc acccgtctcc tcttatgggc ggctttggac     4140

tcaagaaccc gcctcctcag atcctcatca aaaacacgcc tgttcctgcg aatcctccgg     4200

cggagttttc agctacaaag tttgcttcat tcatcaccca atactccaca ggacaagtga     4260

gtgtggaaat tgaatgggag ctgcagaaag aaaacagcaa gcgctggaat cccgaagtgc     4320

agtacacatc caattatgca aaatctgcca acgttgattt tactgtggac aacaatggac     4380

tttatactga gcctcgcccc attggcaccc gttaccttac ccgtcccctg taattacgtg     4440

ttaatcaata aaccggttga ttcgtttcag ttgaactttg gtctcctgtc cttcttatct     4500

tatcggttac catggttata gcttacacat taactgcttg gttgcgcttc gcgataaaag     4560

acttacgtca tcgggttacc cctagtgatg gagttgccca ctccctctct gcgcgctcgc     4620

tcgctcggtg gggcctgcgg accaaaggtc cgcagacggc agagctctgc tctgccggcc     4680

ccaccgagcg agcgagcgcg cagagaggga gtgggcaa                             4718


<210> 5097
<211> 255
<212> DNA
<213> Adeno-associated virus 10

<400> 5097
ggtaattcct ccggaaattg gcattgcgat tccacatggc tgggcgacag agtcatcacc       60

accagcaccc gaacctgggt cctgcccacc tacaacaacc acatctacaa gcaaatctcc      120

agcgagacag gagccaccaa cgacaaccac tacttcggct acagcacccc ctgggggtat      180

tttgacttta acagattcca ctgccacttt tcaccacgtg actggcagcg actcatcaac      240

aacaactggg gattc                                                       255


<210> 5098
<211> 738
<212> PRT
<213> Adeno-associated virus 10

<400> 5098
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Glu Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Ala Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5099
<211> 738
<212> PRT
<213> Adeno-associated virus 10

<400> 5099
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Asp 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5100
<211> 258
<212> DNA
<213> Adeno-associated virus 11

<400> 5100
ggtaattcct ccggaaattg gcattgcgat tccacatggc tgggcgacag agtcatcacc       60

accagcaccc gaacctgggc cctgccaacc tacaacaacc acctctacaa acaaatctcc      120

agcgcttcaa cgggggccag caacgacaac cactactttg gctacagcac cccctggggg      180

tattttgact ttaacagatt ccactgccac ttctcaccac gtgactggca gcgactcatc      240

aacaacaact ggggattc                                                    258


<210> 5101
<211> 255
<212> DNA
<213> Adeno-associated virus 12

<400> 5101
ggtaattcct ccggaaattg gcattgcgat tccacatggc tgggcgaccg agtcattacc       60

accagcaccc ggacttgggc cctgcccacc tacaacaacc acctctacaa gcaaatctcc      120

agccaatcgg gtgccaccaa cgacaaccac tacttcggct acagcacccc ttgggggtat      180

tttgatttca acagattcca ctgccatttc tcaccacgtg actggcagcg actcatcaac      240

aacaactggg gattc                                                       255


<210> 5102
<211> 2208
<212> DNA
<213> Adeno-associated virus 2

<400> 5102
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 5103
<211> 735
<212> PRT
<213> Adeno-associated virus 2

<400> 5103
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 5104
<211> 621
<212> PRT
<213> Adeno-associated virus 2

<400> 5104
Met Pro Gly Phe Tyr Glu Ile Val Ile Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Gly His Leu Pro Gly Ile Ser Asp Ser Phe Val Asn Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Asp Phe Leu 
    50                  55                  60                  


Thr Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Glu Ser Tyr Phe His Met His Val Leu Val Glu 
                85                  90                  95      


Thr Thr Gly Val Lys Ser Met Val Leu Gly Arg Phe Leu Ser Gln Ile 
            100                 105                 110         


Arg Glu Lys Leu Ile Gln Arg Ile Tyr Arg Gly Ile Glu Pro Thr Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Glu Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Glu Gln Tyr Leu 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Thr Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Lys Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys 
            260                 265                 270         


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Gln 
        275                 280                 285             


Pro Val Glu Asp Ile Ser Ser Asn Arg Ile Tyr Lys Ile Leu Glu Leu 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Thr Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Thr Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
        435                 440                 445             


Glu Leu Thr Arg Arg Leu Asp His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Asp Phe Phe Arg Trp Ala Lys Asp His Val Val Glu Val 
465                 470                 475                 480 


Glu His Glu Phe Tyr Val Lys Lys Gly Gly Ala Lys Lys Arg Pro Ala 
                485                 490                 495     


Pro Ser Asp Ala Asp Ile Ser Glu Pro Lys Arg Val Arg Glu Ser Val 
            500                 505                 510         


Ala Gln Pro Ser Thr Ser Asp Ala Glu Ala Ser Ile Asn Tyr Ala Asp 
        515                 520                 525             


Arg Tyr Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu 
    530                 535                 540                 


Phe Pro Cys Arg Gln Cys Glu Arg Met Asn Gln Asn Ser Asn Ile Cys 
545                 550                 555                 560 


Phe Thr His Gly Gln Lys Asp Cys Leu Glu Cys Phe Pro Val Ser Glu 
                565                 570                 575     


Ser Gln Pro Val Ser Val Val Lys Lys Ala Tyr Gln Lys Leu Cys Tyr 
            580                 585                 590         


Ile His His Ile Met Gly Lys Val Pro Asp Ala Cys Thr Ala Cys Asp 
        595                 600                 605             


Leu Val Asn Val Asp Leu Asp Asp Cys Ile Phe Glu Gln 
    610                 615                 620     


<210> 5105
<211> 4675
<212> DNA
<213> Adeno-associated virus 2

<400> 5105
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtgaat tacgtcatag      180

ggttagggag gtcctgtatt agaggtcacg tgagtgtttt gcgacatttt gcgacaccat      240

gtggtcacgc tgggtattta agcccgagtg agcacgcagg gtctccattt tgaagcggga      300

ggtttgaacg cgcagccgcc atgccggggt tttacgagat tgtgattaag gtccccagcg      360

accttgacgg gcatctgccc ggcatttctg acagctttgt gaactgggtg gccgagaagg      420

aatgggagtt gccgccagat tctgacatgg atctgaatct gattgagcag gcacccctga      480

ccgtggccga gaagctgcag cgcgactttc tgacggaatg gcgccgtgtg agtaaggccc      540

cggaggccct tttctttgtg caatttgaga agggagagag ctacttccac atgcacgtgc      600

tcgtggaaac caccggggtg aaatccatgg ttttgggacg tttcctgagt cagattcgcg      660

aaaaactgat tcagagaatt taccgcggga tcgagccgac tttgccaaac tggttcgcgg      720

tcacaaagac cagaaatggc gccggaggcg ggaacaaggt ggtggatgag tgctacatcc      780

ccaattactt gctccccaaa acccagcctg agctccagtg ggcgtggact aatatggaac      840

agtatttaag cgcctgtttg aatctcacgg agcgtaaacg gttggtggcg cagcatctga      900

cgcacgtgtc gcagacgcag gagcagaaca aagagaatca gaatcccaat tctgatgcgc      960

cggtgatcag atcaaaaact tcagccaggt acatggagct ggtcgggtgg ctcgtggaca     1020

aggggattac ctcggagaag cagtggatcc aggaggacca ggcctcatac atctccttca     1080

atgcggcctc caactcgcgg tcccaaatca aggctgcctt ggacaatgcg ggaaagatta     1140

tgagcctgac taaaaccgcc cccgactacc tggtgggcca gcagcccgtg gaggacattt     1200

ccagcaatcg gatttataaa attttggaac taaacgggta cgatccccaa tatgcggctt     1260

ccgtctttct gggatgggcc acgaaaaagt tcggcaagag gaacaccatc tggctgtttg     1320

ggcctgcaac taccgggaag accaacatcg cggaggccat agcccacact gtgcccttct     1380

acgggtgcgt aaactggacc aatgagaact ttcccttcaa cgactgtgtc gacaagatgg     1440

tgatctggtg ggaggagggg aagatgaccg ccaaggtcgt ggagtcggcc aaagccattc     1500

tcggaggaag caaggtgcgc gtggaccaga aatgcaagtc ctcggcccag atagacccga     1560

ctcccgtgat cgtcacctcc aacaccaaca tgtgcgccgt gattgacggg aactcaacga     1620

ccttcgaaca ccagcagccg ttgcaagacc ggatgttcaa atttgaactc acccgccgtc     1680

tggatcatga ctttgggaag gtcaccaagc aggaagtcaa agactttttc cggtgggcaa     1740

aggatcacgt ggttgaggtg gagcatgaat tctacgtcaa aaagggtgga gccaagaaaa     1800

gacccgcccc cagtgacgca gatataagtg agcccaaacg ggtgcgcgag tcagttgcgc     1860

agccatcgac gtcagacgcg gaagcttcga tcaactacgc agacaggtac caaaacaaat     1920

gttctcgtca cgtgggcatg aatctgatgc tgtttccctg cagacaatgc gagagaatga     1980

atcagaattc aaatatctgc ttcactcacg gacagaaaga ctgtttagag tgctttcccg     2040

tgtcagaatc tcaacccgtt tctgtcgtca aaaaggcgta tcagaaactg tgctacattc     2100

atcatatcat gggaaaggtg ccagacgctt gcactgcctg cgatctggtc aatgtggatt     2160

tggatgactg catctttgaa caataaatga tttaaatcag gtatggctgc cgatggttat     2220

cttccagatt ggctcgagga cactctctct gaaggaataa gacagtggtg gaagctcaaa     2280

cctggcccac caccaccaaa gcccgcagag cggcataagg acgacagcag gggtcttgtg     2340

cttcctgggt acaagtacct cggacccttc aacggactcg acaagggaga gccggtcaac     2400

gaggcagacg ccgcggccct cgagcacgta caaagcctac gaccggcagc tcgacagcgg     2460

agacaacccg tacctcaagt acaaccacgc cgacgcggag tttcaggagc gccttaaaga     2520

agatacgtct tttgggggca acctcggacg agcagtcttc caggcgaaaa agagggttct     2580

tgaacctctg ggcctggttg aggaacctgt taagacggct ccgggaaaaa agaggccggt     2640

agagcactct cctgtggagc cagactcctc ctcgggaacc ggaaaggcgg gccagcagcc     2700

tgcaagaaaa agattgaatt ttggtcagac tggagacgca gactcagtac ctgaccccca     2760

gcctctcgga cagccaccag cagccccctc tggtctggga actaatacga tggctacagg     2820

cagtggcgca ccaatggcag acaataacga gggcgccgac ggagtgggta attcctccgg     2880

aaattggcat tgcgattcca catggatggg cgacagagtc atcaccacca gcacccgaac     2940

ctgggccctg cccacctaca acaaccacct ctacaaacaa atttccagcc aatcaggagc     3000

ctcgaacgac aatcactact ttggctacag caccccttgg gggtattttg acttcaacag     3060

attccactgc cacttttcac cacgtgactg gcaaagactc atcaacaaca actggggatt     3120

ccgacccaag agactcaact tcaagctctt taacattcaa gtcaaagagg tcacgcagaa     3180

tgacggtacg acgacgattg ccaataacct taccagcacg gttcaggtgt ttactgactc     3240

ggagtaccag ctcccgtacg tcctcggctc ggcgcatcaa ggatgcctcc cgccgttccc     3300

agcagacgtc ttcatggtgc cacagtatgg atacctcacc ctgaacaacg ggagtcaggc     3360

agtaggacgc tcttcatttt actgcctgga gtactttcct tctcagatgc tgcgtaccgg     3420

aaacaacttt accttcagct acacttttga ggacgttcct ttccacagca gctacgctca     3480

cagccagagt ctggaccgtc tcatgaatcc tctcatcgac cagtacctgt attacttgag     3540

cagaacaaac actccaagtg gaaccaccac gcagtcaagg cttcagtttt ctcaggccgg     3600

agcgagtgac attcgggacc agtctaggaa ctggcttcct ggaccctgtt accgccagca     3660

gcgagtatca aagacatctg cggataacaa caacagtgaa tactcgtgga ctggagctac     3720

caagtaccac ctcaatggca gagactctct ggtgaatccg gccatggcaa gccacaagga     3780

cgatgaagaa aagttttttc ctcagagcgg ggttctcatc tttgggaagc aaggctcaga     3840

gaaaacaaat gtgaacattg aaaaggtcat gattacagac gaagaggaaa tcggaacaac     3900

caatcccgtg gctacggagc agtatggttc tgtatctacc aacctccaga gaggcaacag     3960

acaagcagct accgcagatg tcaacacaca aggcgttctt ccaggcatgg tctggcagga     4020

cagagatgtg taccttcagg ggcccatctg ggcaaagatt ccacacacgg acggacattt     4080

tcacccctct cccctcatgg gtggattcgg acttaaacac cctcctccac agattctcat     4140

caagaacacc ccggtacctg cgaatccttc gaccaccttc agtgcggcaa agtttgcttc     4200

cttcatcaca cagtactcca cgggacacgg tcagcgtgga gatcgagtgg gagctgcaga     4260

aggaaaacag caaacgctgg aatcccgaaa ttcagtacac ttccaactac aacaagtctg     4320

ttaatcgtgg acttaccgtg gatactaatg gcgtgtattc agagcctcgc cccattggca     4380

ccagatacct gactcgtaat ctgtaattgc ttgttaatca ataaaccgtt taattcgttt     4440

cagttgaact ttggtctctg cgtatttctt tcttatctag tttccatggc tacgtagata     4500

agtagcatgg cgggttaatc attaactaca aggaacccct agtgatggag ttggccactc     4560

cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg     4620

gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg gccaa          4675


<210> 5106
<211> 4679
<212> DNA
<213> Adeno-associated virus 2

<400> 5106
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtgaat tacgtcatag      180

ggttagggag gtcctgtatt agaggtcacg tgagtgtttt gcgacatttt gcgacaccat      240

gtggtcacgc tgggtattta agcccgagtg agcacgcagg gtctccattt tgaagcggga      300

ggtttgaacg cgcagccgcc atgccggggt tttacgagat tgtgattaag gtccccagcg      360

accttgacgg gcatctgccc ggcatttctg acagctttgt gaactgggtg gccgagaagg      420

aatgggagtt gccgccagat tctgacatgg atctgaatct gattgagcag gcacccctga      480

ccgtggccga gaagctgcag cgcgactttc tgacggaatg gcgccgtgtg agtaaggccc      540

cggaggccct tttctttgtg caatttgaga agggagagag ctacttccac atgcacgtgc      600

tcgtggaaac caccggggtg aaatccatgg ttttgggacg tttcctgagt cagattcgcg      660

aaaaactgat tcagagaatt taccgcggga tcgagccgac tttgccaaac tggttcgcgg      720

tcacaaagac cagaaatggc gccggaggcg ggaacaaggt ggtggatgag tgctacatcc      780

ccaattactt gctccccaaa acccagcctg agctccagtg ggcgtggact aatatggaac      840

agtatttaag cgcctgtttg aatctcacgg agcgtaaacg gttggtggcg cagcatctga      900

cgcacgtgtc gcagacgcag gagcagaaca aagagaatca gaatcccaat tctgatgcgc      960

cggtgatcag atcaaaaact tcagccaggt acatggagct ggtcgggtgg ctcgtggaca     1020

aggggattac ctcggagaag cagtggatcc aggaggacca ggcctcatac atctccttca     1080

atgcggcctc caactcgcgg tcccaaatca aggctgcctt ggacaatgcg ggaaagatta     1140

tgagcctgac taaaaccgcc cccgactacc tggtgggcca gcagcccgtg gaggacattt     1200

ccagcaatcg gatttataaa attttggaac taaacgggta cgatccccaa tatgcggctt     1260

ccgtctttct gggatgggcc acgaaaaagt tcggcaagag gaacaccatc tggctgtttg     1320

ggcctgcaac taccgggaag accaacatcg cggaggccat agcccacact gtgcccttct     1380

acgggtgcgt aaactggacc aatgagaact ttcccttcaa cgactgtgtc gacaagatgg     1440

tgatctggtg ggaggagggg aagatgaccg ccaaggtcgt ggagtcggcc aaagccattc     1500

tcggaggaag caaggtgcgc gtggaccaga aatgcaagtc ctcggcccag atagacccga     1560

ctcccgtgat cgtcacctcc aacaccaaca tgtgcgccgt gattgacggg aactcaacga     1620

ccttcgaaca ccagcagccg ttgcaagacc ggatgttcaa atttgaactc acccgccgtc     1680

tggatcatga ctttgggaag gtcaccaagc aggaagtcaa agactttttc cggtgggcaa     1740

aggatcacgt ggttgaggtg gagcatgaat tctacgtcaa aaagggtgga gccaagaaaa     1800

gacccgcccc cagtgacgca gatataagtg agcccaaacg ggtgcgcgag tcagttgcgc     1860

agccatcgac gtcagacgcg gaagcttcga tcaactacgc agacaggtac caaaacaaat     1920

gttctcgtca cgtgggcatg aatctgatgc tgtttccctg cagacaatgc gagagaatga     1980

atcagaattc aaatatctgc ttcactcacg gacagaaaga ctgtttagag tgctttcccg     2040

tgtcagaatc tcaacccgtt tctgtcgtca aaaaggcgta tcagaaactg tgctacattc     2100

atcatatcat gggaaaggtg ccagacgctt gcactgcctg cgatctggtc aatgtggatt     2160

tggatgactg catctttgaa caataaatga tttaaatcag gtatggctgc cgatggttat     2220

cttccagatt ggctcgagga cactctctct gaaggaataa gacagtggtg gaagctcaaa     2280

cctggcccac caccaccaaa gcccgcagag cggcataagg acgacagcag gggtcttgtg     2340

cttcctgggt acaagtacct cggacccttc aacggactcg acaagggaga gccggtcaac     2400

gaggcagacg ccgcggccct cgagcacgac aaagcctacg accggcagct cgacagcgga     2460

gacaacccgt acctcaagta caaccacgcc gacgcggagt ttcaggagcg ccttaaagaa     2520

gatacgtctt ttgggggcaa cctcggacga gcagtcttcc aggcgaaaaa gagggttctt     2580

gaacctctgg gcctggttga ggaacctgtt aagacggctc cgggaaaaaa gaggccggta     2640

gagcactctc ctgtggagcc agactcctcc tcgggaaccg gaaaggcggg ccagcagcct     2700

gcaagaaaaa gattgaattt tggtcagact ggagacgcag actcagtacc tgacccccag     2760

cctctcggac agccaccagc agccccctct ggtctgggaa ctaatacgat ggctacaggc     2820

agtggcgcac caatggcaga caataacgag ggcgccgacg gagtgggtaa ttcctccgga     2880

aattggcatt gcgattccac atggatgggc gacagagtca tcaccaccag cacccgaacc     2940

tgggccctgc ccacctacaa caaccacctc tacaaacaaa tttccagcca atcaggagcc     3000

tcgaacgaca atcactactt tggctacagc accccttggg ggtattttga cttcaacaga     3060

ttccactgcc acttttcacc acgtgactgg caaagactca tcaacaacaa ctggggattc     3120

cgacccaaga gactcaactt caagctcttt aacattcaag tcaaagaggt cacgcagaat     3180

gacggtacga cgacgattgc caataacctt accagcacgg ttcaggtgtt tactgactcg     3240

gagtaccagc tcccgtacgt cctcggctcg gcgcatcaag gatgcctccc gccgttccca     3300

gcagacgtct tcatggtgcc acagtatgga tacctcaccc tgaacaacgg gagtcaggca     3360

gtaggacgct cttcatttta ctgcctggag tactttcctt ctcagatgct gcgtaccgga     3420

aacaacttta ccttcagcta cacttttgag gacgttcctt tccacagcag ctacgctcac     3480

agccagagtc tggaccgtct catgaatcct ctcatcgacc agtacctgta ttacttgagc     3540

agaacaaaca ctccaagtgg aaccaccacg cagtcaaggc ttcagttttc tcaggccgga     3600

gcgagtgaca ttcgggacca gtctaggaac tggcttcctg gaccctgtta ccgccagcag     3660

cgagtatcaa agacatctgc ggataacaac aacagtgaat actcgtggac tggagctacc     3720

aagtaccacc tcaatggcag agactctctg gtgaatccgg gcccggccat ggcaagccac     3780

aaggacgatg aagaaaagtt ttttcctcag agcggggttc tcatctttgg gaagcaaggc     3840

tcagagaaaa caaatgtgga cattgaaaag gtcatgatta cagacgaaga ggaaatcagg     3900

acaaccaatc ccgtggctac ggagcagtat ggttctgtat ctaccaacct ccagagaggc     3960

aacagacaag cagctaccgc agatgtcaac acacaaggcg ttcttccagg catggtctgg     4020

caggacagag atgtgtacct tcaggggccc atctgggcaa agattccaca cacggacgga     4080

cattttcacc cctctcccct catgggtgga ttcggactta aacaccctcc tccacagatt     4140

ctcatcaaga acaccccggt acctgcgaat ccttcgacca ccttcagtgc ggcaaagttt     4200

gcttccttca tcacacagta ctccacggga caggtcagcg tggagatcga gtgggagctg     4260

cagaaggaaa acagcaaacg ctggaatccc gaaattcagt acacttccaa ctacaacaag     4320

tctgttaatg tggactttac tgtggacact aatggcgtgt attcagagcc tcgccccatt     4380

ggcaccagat acctgactcg taatctgtaa ttgcttgtta atcaataaac cgtttaattc     4440

gtttcagttg aactttggtc tctgcgtatt tctttcttat ctagtttcca tggctacgta     4500

gataagtagc atggcgggtt aatcattaac tacaaggaac ccctagtgat ggagttggcc     4560

actccctctc tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc     4620

ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc gcagagaggg agtggccaa      4679


<210> 5107
<211> 735
<212> PRT
<213> Adeno-associated virus 2

<400> 5107
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asp Lys Ala Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro 
                725                 730                 735 


<210> 5108
<211> 740
<212> PRT
<213> Adeno-associated virus 2

<400> 5108
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Gly Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu Leu 
                725                 730                 735     


Leu Ala Ala Ala 
            740 


<210> 5109
<211> 734
<212> PRT
<213> Adeno-associated virus 2

<400> 5109
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Gly Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Met Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Ile Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 


<210> 5110
<211> 734
<212> PRT
<213> Adeno-associated virus 2

<400> 5110
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Gly Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Glu Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 


<210> 5111
<211> 739
<212> PRT
<213> Adeno-associated virus 2

<400> 5111
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Gly Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu Leu 
                725                 730                 735     


Leu Ala Ala 
            


<210> 5112
<211> 725
<212> PRT
<213> Adeno-associated virus 2

<400> 5112
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Gly Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro 
                725 


<210> 5113
<211> 707
<212> PRT
<213> Adeno-associated virus 2

<400> 5113
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Gly Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Cys Ile Tyr Gln Pro Pro Glu Arg Gln Gln Thr Ser Ser Tyr 
            580                 585                 590         


Arg Arg Cys Gln His Thr Arg Arg Ser Ser Arg His Gly Leu Ala Gly 
        595                 600                 605             


Gln Arg Cys Val Pro Ser Gly Ala His Leu Gly Lys Asp Ser Thr His 
    610                 615                 620                 


Gly Arg Thr Phe Ser Pro Leu Ser Pro His Gly Trp Ile Arg Thr Thr 
625                 630                 635                 640 


Pro Ser Ser Thr Asp Ser His Gln Glu His Pro Gly Thr Cys Glu Ser 
                645                 650                 655     


Phe Asp His Leu Gln Cys Gly Lys Val Cys Phe Leu His His Thr Val 
            660                 665                 670         


Leu His Gly Thr Gly Gln Arg Gly Asp Arg Val Arg Ala Ala Glu Gly 
        675                 680                 685             


Lys Gln Gln Thr Leu Glu Ser Arg Asn Ser Val His Phe Gln Leu Gln 
    690                 695                 700                 


Gln Val Cys 
705         


<210> 5114
<211> 739
<212> PRT
<213> Adeno-associated virus 2

<400> 5114
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Gly Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu Leu 
                725                 730                 735     


Leu Ala Ala 
            


<210> 5115
<211> 737
<212> PRT
<213> Adeno-associated virus 2

<400> 5115
Met Ala Ser Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg 
        435                 440                 445             


Thr Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Gly Leu Gln Phe Ser 
    450                 455                 460                 


Gln Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn 
                485                 490                 495     


Asn Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala 
            580                 585                 590         


Thr Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His His Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


Leu 
    


<210> 5116
<211> 741
<212> PRT
<213> Adeno-associated virus 2

<400> 5116
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ser Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Gly Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Leu Ala Asn His Asn 
            580                 585                 590         


Asn Thr Thr Asn Ala Arg Gln Ala Ala Thr Ala Asp Val Asn Thr Gln 
        595                 600                 605             


Gly Val Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln 
    610                 615                 620                 


Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro 
625                 630                 635                 640 


Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile 
                645                 650                 655     


Leu Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Ser Thr Thr Phe Ser 
            660                 665                 670         


Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val 
        675                 680                 685             


Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp 
    690                 695                 700                 


Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Asn Lys Ser Ile Asn Val 
705                 710                 715                 720 


Asp Phe Thr Val Asp Thr Asn Gly Val Tyr Ser Glu Pro Arg Pro Ile 
                725                 730                 735     


Gly Thr Arg Tyr Leu 
            740     


<210> 5117
<211> 730
<212> PRT
<213> Adeno-associated virus 2

<400> 5117
Met Ala Ser Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Asn Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg 
                725                 730 


<210> 5118
<211> 735
<212> PRT
<213> Adeno-associated virus 2


<220>
<221> MOD_RES
<222> (239)..(239)
<223> Any amino acid

<400> 5118
Met Ala Ser Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Xaa Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Asn Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro 
                725                 730                 735 


<210> 5119
<211> 733
<212> PRT
<213> Adeno-associated virus 2

<400> 5119
Met Ala Ser Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Leu Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Asn Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr 
                725                 730             


<210> 5120
<211> 734
<212> PRT
<213> Adeno-associated virus 2

<400> 5120
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Cys Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Asn Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Asn Gln Ser Gly Ser Ala Gln Asn Asn Asp Leu Leu Phe Ser Arg 
    450                 455                 460                 


Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn Gly 
            500                 505                 510         


Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly Lys 
    530                 535                 540                 


Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg Phe 
                565                 570                 575     


Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala Thr 
            580                 585                 590         


Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu Tyr 
705                 710                 715                 720 


Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro 
                725                 730                 


<210> 5121
<211> 734
<212> PRT
<213> Adeno-associated virus 2

<400> 5121
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Ser Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Ile Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 


<210> 5122
<211> 738
<212> PRT
<213> Adeno-associated virus 2

<400> 5122
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Gly Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Gly Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu Leu 
                725                 730                 735     


Arg Pro 
        


<210> 5123
<211> 736
<212> PRT
<213> Adeno-associated virus 3

<400> 5123
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Val Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Arg Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Gly 
    130                 135                 140                 


Ala Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Arg Gly Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 5124
<211> 4726
<212> DNA
<213> Adeno-associated virus 3

<400> 5124
ttggccactc cctctatgcg cactcgctcg ctcggtgggg cctggcgacc aaaggtcgcc       60

agacggacgt gctttgcacg tccggcccca ccgagcgagc gagtgcgcat agagggagtg      120

gccaactcca tcactagagg tatggcagtg acgtaacgcg aagcgcgcga agcgagacca      180

cgcctaccag ctgcgtcagc agtcaggtga cccttttgcg acagtttgcg acaccacgtg      240

gccgctgagg gtatatattc tcgagtgagc gaaccaggag ctccattttg accgcgaaat      300

ttgaacgagc agcagccatg ccggggttct acgagattgt cctgaaggtc ccgagtgacc      360

tggacgagcg cctgccgggc atttctaact cgtttgttaa ctgggtggcc gagaaggaat      420

gggacgtgcc gccggattct gacatggatc cgaatctgat tgagcaggca cccctgaccg      480

tggccgaaaa gcttcagcgc gagttcctgg tggagtggcg ccgcgtgagt aaggccccgg      540

aggccctctt ttttgtccag ttcgaaaagg gggagaccta cttccacctg cacgtgctga      600

ttgagaccat cggggtcaaa tccatggtgg tcggccgcta cgtgagccag attaaagaga      660

agctggtgac ccgcatctac cgcggggtcg agccgcagct tccgaactgg ttcgcggtga      720

ccaaaacgcg aaatggcgcc gggggcggga acaaggtggt ggacgactgc tacatcccca      780

actacctgct ccccaagacc cagcccgagc tccagtgggc gtggactaac atggaccagt      840

atttaagcgc ctgtttgaat ctcgcggagc gtaaacggct ggtggcgcag catctgacgc      900

acgtgtcgca gacgcaggag cagaacaaag agaatcagaa ccccaattct gacgcgccgg      960

tcatcaggtc aaaaacctca gccaggtaca tggagctggt cgggtggctg gtggaccgcg     1020

ggatcacgtc agaaaagcaa tggattcagg aggaccaggc ctcgtacatc tccttcaacg     1080

ccgcctccaa ctcgcggtcc cagatcaagg ccgcgctgga caatgcctcc aagatcatga     1140

gcctgacaaa gacggctccg gactacctgg tgggcagcaa cccgccggag gacattacca     1200

aaaatcggat ctaccaaatc ctggagctga acgggtacga tccgcagtac gcggcctccg     1260

tcttcctggg ctgggcgcaa aagaagttcg ggaagaggaa caccatctgg ctctttgggc     1320

cggccacgac gggtaaaacc aacatcgcgg aagccatcgc ccacgccgtg cccttctacg     1380

gctgcgtaaa ctggaccaat gagaactttc ccttcaacga ttgcgtcgac aagatggtga     1440

tctggtggga ggagggcaag atgacggcca aggtcgtgga gagcgccaag gccattctgg     1500

gcggaagcaa ggtgcgcgtg gaccaaaagt gcaagtcatc ggcccagatc gaacccactc     1560

ccgtgatcgt cacctccaac accaacatgt gcgccgtgat tgacgggaac agcaccacct     1620

tcgagcatca gcagccgctg caggaccgga tgtttgaatt tgaacttacc cgccgtttgg     1680

accatgactt tgggaaggtc accaaacagg aagtaaagga ctttttccgg tgggcttccg     1740

atcacgtgac tgacgtggct catgagttct acgtcagaaa gggtggagct aagaaacgcc     1800

ccgcctccaa tgacgcggat gtaagcgagc caaaacggga gtgcacgtca cttgcgcagc     1860

cgacaacgtc agacgcggaa gcaccggcgg actacgcgga caggtaccaa aacaaatgtt     1920

ctcgtcacgt gggcatgaat ctgatgcttt ttccctgtaa aacatgcgag agaatgaatc     1980

aaatttccaa tgtctgtttt acgcatggtc aaagagactg tggggaatgc ttccctggaa     2040

tgtcagaatc tcaacccgtt tctgtcgtca aaaagaagac ttatcagaaa ctgtgtccaa     2100

ttcatcatat cctgggaagg gcacccgaga ttgcctgttc ggcctgcgat ttggccaatg     2160

tggacttgga tgactgtgtt tctgagcaat aaatgactta aaccaggtat ggctgctgac     2220

ggttatcttc cagattggct cgaggacaac ctttctgaag gcattcgtga gtggtgggct     2280

ctgaaacctg gagtccctca acccaaagcg aaccaacaac accaggacaa ccgtcggggt     2340

cttgtgcttc cgggttacaa atacctcgga cccggtaacg gactcgacaa aggagagccg     2400

gtcaacgagg cggacgcggc agccctcgaa cacgacaaag cttacgacca gcagctcaag     2460

gccggtgaca acccgtacct caagtacaac cacgccgacg ccgagtttca ggagcgtctt     2520

caagaagata cgtcttttgg gggcaacctt ggcagagcag tcttccaggc caaaaagagg     2580

atccttgagc ctcttggtct ggttgaggaa gcagctaaaa cggctcctgg aaagaagggg     2640

gctgtagatc agtctcctca ggaaccggac tcatcatctg gtgttggcaa atcgggcaaa     2700

cagcctgcca gaaaaagact aaatttcggt cagactggag actcagagtc agtcccagac     2760

cctcaacctc tcggagaacc accagcagcc cccacaagtt tgggatctaa tacaatggct     2820

tcaggcggtg gcgcaccaat ggcagacaat aacgagggtg ccgatggagt gggtaattcc     2880

tcaggaaatt ggcattgcga ttcccaatgg ctgggcgaca gagtcatcac caccagcacc     2940

agaacctggg ccctgcccac ttacaacaac catctctaca agcaaatctc cagccaatca     3000

ggagcttcaa acgacaacca ctactttggc tacagcaccc cttgggggta ttttgacttt     3060

aacagattcc actgccactt ctcaccacgt gactggcagc gactcattaa caacaactgg     3120

ggattccggc ccaagaaact cagcttcaag ctcttcaaca tccaagttag aggggtcacg     3180

cagaacgatg gcacgacgac tattgccaat aaccttacca gcacggttca agtgtttacg     3240

gactcggagt atcagctccc gtacgtgctc gggtcggcgc accaaggctg tctcccgccg     3300

tttccagcgg acgtcttcat ggtccctcag tatggatacc tcaccctgaa caacggaagt     3360

caagcggtgg gacgctcatc cttttactgc ctggagtact tcccttcgca gatgctaagg     3420

actggaaata acttccaatt cagctatacc ttcgaggatg taccttttca cagcagctac     3480

gctcacagcc agagtttgga tcgcttgatg aatcctctta ttgatcagta tctgtactac     3540

ctgaacagaa cgcaaggaac aacctctgga acaaccaacc aatcacggct gctttttagc     3600

caggctgggc ctcagtctat gtctttgcag gccagaaatt ggctacctgg gccctgctac     3660

cggcaacaga gactttcaaa gactgctaac gacaacaaca acagtaactt tccttggaca     3720

gcggccagca aatatcatct caatggccgc gactcgctgg tgaatccagg accagctatg     3780

gccagtcaca aggacgatga agaaaaattt ttccctatgc acggcaatct aatatttggc     3840

aaagaaggga caacggcaag taacgcagaa ttagataatg taatgattac ggatgaagaa     3900

gagattcgta ccaccaatcc tgtggcaaca gagcagtatg gaactgtggc aaataacttg     3960

cagagctcaa atacagctcc cacgactgga actgtcaatc atcagggggc cttacctggc     4020

atggtgtggc aagatcgtga cgtgtacctt caaggaccta tctgggcaaa gattcctcac     4080

acggatggac actttcatcc ttctcctctg atgggaggct ttggactgaa acatccgcct     4140

cctcaaatca tgatcaaaaa tactccggta ccggcaaatc ctccgacgac tttcagcccg     4200

gccaagtttg cttcatttat cactcagtac tccactggac aggtcagcgt ggaaattgag     4260

tgggagctac agaaagaaaa cagcaaacgt tggaatccag agattcagta cacttccaac     4320

tacaacaagt ctgttaatgt ggactttact gtagacacta atggtgttta tagtgaacct     4380

cgccctattg gaacccggta tctcacacga aacttgtgaa tcctggttaa tcaataaacc     4440

gtttaattcg tttcagttga actttggctc ttgtgcactt ctttatcttt atcttgtttc     4500

catggctact gcgtagataa gcagcggcct gcggcgcttg cgcttcgcgg tttacaactg     4560

ctggttaata tttaactctc gccatacctc tagtgatgga gttggccact ccctctatgc     4620

gcactcgctc gctcggtggg gcctggcgac caaaggtcgc cagacggacg tgctttgcac     4680

gtccggcccc accgagcgag cgagtgcgca tagagggagt ggccaa                    4726


<210> 5125
<211> 736
<212> PRT
<213> Adeno-associated virus 3A

<400> 5125
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Val Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Arg Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Gly 
    130                 135                 140                 


Ala Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Arg Gly Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 5126
<211> 624
<212> PRT
<213> Adeno-associated virus 3A

<400> 5126
Met Pro Gly Phe Tyr Glu Ile Val Leu Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Glu Arg Leu Pro Gly Ile Ser Asn Ser Phe Val Asn Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Asp Val Pro Pro Asp Ser Asp Met Asp Pro Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Glu Phe Leu 
    50                  55                  60                  


Val Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Glu Thr Tyr Phe His Leu His Val Leu Ile Glu 
                85                  90                  95      


Thr Ile Gly Val Lys Ser Met Val Val Gly Arg Tyr Val Ser Gln Ile 
            100                 105                 110         


Lys Glu Lys Leu Val Thr Arg Ile Tyr Arg Gly Val Glu Pro Gln Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Asp Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Asp Gln Tyr Leu 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Ala Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Arg Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Ser Lys 
            260                 265                 270         


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Ser Asn 
        275                 280                 285             


Pro Pro Glu Asp Ile Thr Lys Asn Arg Ile Tyr Gln Ile Leu Glu Leu 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Gln Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Ala Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Glu Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Glu Phe 
        435                 440                 445             


Glu Leu Thr Arg Arg Leu Asp His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Asp Phe Phe Arg Trp Ala Ser Asp His Val Thr Asp Val 
465                 470                 475                 480 


Ala His Glu Phe Tyr Val Arg Lys Gly Gly Ala Lys Lys Arg Pro Ala 
                485                 490                 495     


Ser Asn Asp Ala Asp Val Ser Glu Pro Lys Arg Glu Cys Thr Ser Leu 
            500                 505                 510         


Ala Gln Pro Thr Thr Ser Asp Ala Glu Ala Pro Ala Asp Tyr Ala Asp 
        515                 520                 525             


Arg Tyr Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu 
    530                 535                 540                 


Phe Pro Cys Lys Thr Cys Glu Arg Met Asn Gln Ile Ser Asn Val Cys 
545                 550                 555                 560 


Phe Thr His Gly Gln Arg Asp Cys Gly Glu Cys Phe Pro Gly Met Ser 
                565                 570                 575     


Glu Ser Gln Pro Val Ser Val Val Lys Lys Lys Thr Tyr Gln Lys Leu 
            580                 585                 590         


Cys Pro Ile His His Ile Leu Gly Arg Ala Pro Glu Ile Ala Cys Ser 
        595                 600                 605             


Ala Cys Asp Leu Ala Asn Val Asp Leu Asp Asp Cys Val Ser Glu Gln 
    610                 615                 620                 


<210> 5127
<211> 736
<212> PRT
<213> Adeno-associated virus 3B

<400> 5127
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Val Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Arg Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 5128
<211> 624
<212> PRT
<213> Adeno-associated virus 3B

<400> 5128
Met Pro Gly Phe Tyr Glu Ile Val Leu Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Glu His Leu Pro Gly Ile Ser Asn Ser Phe Val Asn Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Pro Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Glu Phe Leu 
    50                  55                  60                  


Val Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Glu Thr Tyr Phe His Leu His Val Leu Ile Glu 
                85                  90                  95      


Thr Ile Gly Val Lys Ser Met Val Val Gly Arg Tyr Val Ser Gln Ile 
            100                 105                 110         


Lys Glu Lys Leu Val Thr Arg Ile Tyr Arg Gly Val Glu Pro Gln Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Asp Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Asp Gln Tyr Leu 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Ala Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Arg Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Ser Lys 
            260                 265                 270         


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Ser Asn 
        275                 280                 285             


Pro Pro Glu Asp Ile Thr Lys Asn Arg Ile Tyr Gln Ile Leu Glu Leu 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Gln Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Ala Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Glu Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
        435                 440                 445             


Glu Leu Thr Arg Arg Leu Asp His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Asp Phe Phe Arg Trp Ala Ser Asp His Val Thr Asp Val 
465                 470                 475                 480 


Ala His Glu Phe Tyr Val Arg Lys Gly Gly Ala Lys Lys Arg Pro Ala 
                485                 490                 495     


Ser Asn Asp Ala Asp Val Ser Glu Pro Lys Arg Gln Cys Thr Ser Leu 
            500                 505                 510         


Ala Gln Pro Thr Thr Ser Asp Ala Glu Ala Pro Ala Asp Tyr Ala Asp 
        515                 520                 525             


Arg Tyr Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu 
    530                 535                 540                 


Phe Pro Cys Lys Thr Cys Glu Arg Met Asn Gln Ile Ser Asn Val Cys 
545                 550                 555                 560 


Phe Thr His Gly Gln Arg Asp Cys Gly Glu Cys Phe Pro Gly Met Ser 
                565                 570                 575     


Glu Ser Gln Pro Val Ser Val Val Lys Lys Lys Thr Tyr Gln Lys Leu 
            580                 585                 590         


Cys Pro Ile His His Ile Leu Gly Arg Ala Pro Glu Ile Ala Cys Ser 
        595                 600                 605             


Ala Cys Asp Leu Ala Asn Val Asp Leu Asp Asp Cys Val Ser Glu Gln 
    610                 615                 620                 


<210> 5129
<211> 4722
<212> DNA
<213> Adeno-associated virus 3B

<400> 5129
tggccactcc ctctatgcgc actcgctcgc tcggtggggc ctggcgacca aaggtcgcca       60

gacggacgtg ctttgcacgt ccggccccac cgagcgagcg agtgcgcata gagggagtgg      120

ccaactccat cactagaggt atggcagtga cgtaacgcga agcgcgcgaa gcgagaccac      180

gcctaccagc tgcgtcagca gtcaggtgac ccttttgcga cagtttgcga caccacgtgg      240

ccgctgaggg tatatattct cgagtgagcg aaccaggagc tccattttga ccgcgaaatt      300

tgaacgagca gcagccatgc cggggttcta cgagattgtc ctgaaggtcc cgagtgacct      360

ggacgagcac ctgccgggca tttctaactc gtttgttaac tgggtggccg agaaggaatg      420

ggagctgccg ccggattctg acatggatcc gaatctgatt gagcaggcac ccctgaccgt      480

ggccgaaaag cttcagcgcg agttcctggt ggagtggcgc cgcgtgagta aggccccgga      540

ggccctcttt tttgtccagt tcgaaaaggg ggagacctac ttccacctgc acgtgctgat      600

tgagaccatc ggggtcaaat ccatggtggt cggccgctac gtgagccaga ttaaagagaa      660

gctggtgacc cgcatctacc gcggggtcga gccgcagctt ccgaactggt tcgcggtgac      720

caaaacgcga aatggcgccg ggggcgggaa caaggtggtg gacgactgct acatccccaa      780

ctacctgctc cccaagaccc agcccgagct ccagtgggcg tggactaaca tggaccagta      840

tttaagcgcc tgtttgaatc tcgcggagcg taaacggctg gtggcgcagc atctgacgca      900

cgtgtcgcag acgcaggagc agaacaaaga gaatcagaac cccaattctg acgcgccggt      960

catcaggtca aaaacctcag ccaggtacat ggagctggtc gggtggctgg tggaccgcgg     1020

gatcacgtca gaaaagcaat ggattcagga ggaccaggcc tcgtacatct ccttcaacgc     1080

cgcctccaac tcgcggtccc agatcaaggc cgcgctggac aatgcctcca agatcatgag     1140

cctgacaaag acggctccgg actacctggt gggcagcaac ccgccggagg acattaccaa     1200

aaatcggatc taccaaatcc tggagctgaa cgggtacgat ccgcagtacg cggcctccgt     1260

cttcctgggc tgggcgcaaa agaagttcgg gaagaggaac accatctggc tctttgggcc     1320

ggccacgacg ggtaaaacca acatcgcgga agccatcgcc cacgccgtgc ccttctacgg     1380

ctgcgtaaac tggaccaatg agaactttcc cttcaacgat tgcgtcgaca agatggtgat     1440

ctggtgggag gagggcaaga tgacggccaa ggtcgtggag agcgccaagg ccattctggg     1500

cggaagcaag gtgcgcgtgg accaaaagtg caagtcatcg gcccagatcg aacccactcc     1560

cgtgatcgtc acctccaaca ccaacatgtg cgccgtgatt gacgggaaca gcaccacctt     1620

cgagcatcag cagccgctgc aggaccggat gtttaaattt gaacttaccc gccgtttgga     1680

ccatgacttt gggaaggtca ccaaacagga agtaaaggac tttttccggt gggcttccga     1740

tcacgtgact gacgtggctc atgagttcta cgtcagaaag ggtggagcta agaaacgccc     1800

cgcctccaat gacgcggatg taagcgagcc aaaacggcag tgcacgtcac ttgcgcagcc     1860

gacaacgtca gacgcggaag caccggcgga ctacgcggac aggtaccaaa acaaatgttc     1920

tcgtcacgtg ggcatgaatc tgatgctttt tccctgtaaa acatgcgaga gaatgaatca     1980

aatttccaat gtctgtttta cgcatggtca aagagactgt ggggaatgct tccctggaat     2040

gtcagaatct caacccgttt ctgtcgtcaa aaagaagact tatcagaaac tgtgtccaat     2100

tcatcatatc ctgggaaggg cacccgagat tgcctgttcg gcctgcgatt tggccaatgt     2160

ggacttggat gactgtgttt ctgagcaata aatgacttaa accaggtatg gctgctgacg     2220

gttatcttcc agattggctc gaggacaacc tttctgaagg cattcgtgag tggtgggctc     2280

tgaaacctgg agtccctcaa cccaaagcga accaacaaca ccaggacaac cgtcggggtc     2340

ttgtgcttcc gggttacaaa tacctcggac ccggtaacgg actcgacaaa ggagagccgg     2400

tcaacgaggc ggacgcggca gccctcgaac acgacaaagc ttacgaccag cagctcaagg     2460

ccggtgacaa cccgtacctc aagtacaacc acgccgacgc cgagtttcag gagcgtcttc     2520

aagaagatac gtcttttggg ggcaaccttg gcagagcagt cttccaggcc aaaaagagga     2580

tccttgagcc tcttggtctg gttgaggaag cagctaaaac ggctcctgga aagaagaggc     2640

ctgtagatca gtctcctcag gaaccggact catcatctgg tgttggcaaa tcgggcaaac     2700

agcctgccag aaaaagacta aatttcggtc agactggcga ctcagagtca gtcccagacc     2760

ctcaacctct cggagaacca ccagcagccc ccacaagttt gggatctaat acaatggctt     2820

caggcggtgg cgcaccaatg gcagacaata acgagggtgc cgatggagtg ggtaattcct     2880

caggaaattg gcattgcgat tcccaatggc tgggcgacag agtcatcacc accagcacca     2940

gaacctgggc cctgcccact tacaacaacc atctctacaa gcaaatctcc agccaatcag     3000

gagcttcaaa cgacaaccac tactttggct acagcacccc ttgggggtat tttgacttta     3060

acagattcca ctgccacttc tcaccacgtg actggcagcg actcattaac aacaactggg     3120

gattccggcc caagaaactc agcttcaagc tcttcaacat ccaagttaaa gaggtcacgc     3180

agaacgatgg cacgacgact attgccaata accttaccag cacggttcaa gtgtttacgg     3240

actcggagta tcagctcccg tacgtgctcg ggtcggcgca ccaaggctgt ctcccgccgt     3300

ttccagcgga cgtcttcatg gtccctcagt atggatacct caccctgaac aacggaagtc     3360

aagcggtggg acgctcatcc ttttactgcc tggagtactt cccttcgcag atgctaagga     3420

ctggaaataa cttccaattc agctatacct tcgaggatgt accttttcac agcagctacg     3480

ctcacagcca gagtttggat cgcttgatga atcctcttat tgatcagtat ctgtactacc     3540

tgaacagaac gcaaggaaca acctctggaa caaccaacca atcacggctg ctttttagcc     3600

aggctgggcc tcagtctatg tctttgcagg ccagaaattg gctacctggg ccctgctacc     3660

ggcaacagag actttcaaag actgctaacg acaacaacaa cagtaacttt ccttggacag     3720

cggccagcaa atatcatctc aatggccgcg actcgctggt gaatccagga ccagctatgg     3780

ccagtcacaa ggacgatgaa gaaaaatttt tccctatgca cggcaatcta atatttggca     3840

aagaagggac aacggcaagt aacgcagaat tagataatgt aatgattacg gatgaagaag     3900

agattcgtac caccaatcct gtggcaacag agcagtatgg aactgtggca aataacttgc     3960

agagctcaaa tacagctccc acgactagaa ctgtcaatga tcagggggcc ttacctggca     4020

tggtgtggca agatcgtgac gtgtaccttc aaggacctat ctgggcaaag attcctcaca     4080

cggatggaca ctttcatcct tctcctctga tgggaggctt tggactgaaa catccgcctc     4140

ctcaaatcat gatcaaaaat actccggtac cggcaaatcc tccgacgact ttcagcccgg     4200

ccaagtttgc ttcatttatc actcagtact ccactggaca ggtcagcgtg gaaattgagt     4260

gggagctaca gaaagaaaac agcaaacgtt ggaatccaga gattcagtac acttccaact     4320

acaacaagtc tgttaatgtg gactttactg tagacactaa tggtgtttat agtgaacctc     4380

gccctattgg aacccggtat ctcacacgaa acttgtaatc ctggttaatc aataaaccgt     4440

ttaattcgtt tcagttgaac tttggctctt gtgcacttct tatcttatct tgtttccatg     4500

gctactgcgt agataagcag cggcctgcgg cgcttgcgct tcgcggttta caactgctgg     4560

ttaatattta actctcgcca tacctctagt gatggagttg gccactccct ctatgcgcac     4620

tcgctcgctc ggtggggccg gacgtgcaaa gcacgtccgt ctggcgacct ttggtcgcca     4680

ggccccaccg agcgagcgag tgcgcataga gggagtggcc aa                        4722


<210> 5130
<211> 1800
<212> DNA
<213> Adeno-associated virus 4


<220>
<221> modified_base
<222> (342)..(342)
<223> a, c, t or g

<400> 5130
acggctcctg gaaagaagag accgttgatt gaatcccccc agcagcccga ctcctccacg       60

ggtatcggca aaaaaggcaa gcagccggct aaaaagaagc tcgttttcga agacgaaact      120

ggagcaggcg acggaccccc tgagggatca acttccggag ccatgtctga tgacagtgag      180

atgcgtgcag cagctggcgg agctgcagtc gagggsggac aaggtgccga tggagtgggt      240

aatgcctcgg gtgattggca ttgcgattcc acctggtctg agggccacgt cacgaccacc      300

agcaccagaa cctgggtctt gcccacctac aacaaccacc tntacaagcg actcggagag      360

agcctgcagt ccaacaccta caacggattc tccaccccct ggggatactt tgacttcaac      420

cgcttccact gccacttctc accacgtgac tggcagcgac tcatcaacaa caactggggc      480

atgcgaccca aagccatgcg ggtcaaaatc ttcaacatcc aggtcaagga ggtcacgacg      540

tcgaacggcg agacaacggt ggctaataac cttaccagca cggttcagat ctttgcggac      600

tcgtcgtacg aactgccgta cgtgatggat gcgggtcaag agggcagcct gcctcctttt      660

cccaacgacg tctttatggt gccccagtac ggctactgtg gactggtgac cggcaacact      720

tcgcagcaac agactgacag aaatgccttc tactgcctgg agtactttcc ttcgcagatg      780

ctgcggactg gcaacaactt tgaaattacg tacagttttg agaaggtgcc tttccactcg      840

atgtacgcgc acagccagag cctggaccgg ctgatgaacc ctctcatcga ccagtacctg      900

tggggactgc aatcgaccac caccggaacc accctgaatg ccgggactgc caccaccaac      960

tttaccaagc tgcggcctac caacttttcc aactttaaaa agaactggct gcccgggcct     1020

tcaatcaagc agcagggctt ctcaaagact gccaatcaaa actacaagat ccctgccacc     1080

gggtcagaca gtctcatcaa atacgagacg cacagcactc tggacggaag atggagtgcc     1140

ctgacccccg gacctccaat ggccacggct ggacctgcgg acagcaagtt cagcaacagc     1200

cagctcatct ttgcggggcc taaacagaac ggcaacacgg ccaccgtacc cgggactctg     1260

atcttcacct ctgaggagga gctggcagcc accaacgcca ccgatacgga catgtggggc     1320

aacctacctg gcggtgacca gagcaacagc aacctgccga ccgtggacag actgacagcc     1380

ttgggagccg tgcctggaat ggtctggcaa aacagagaca tttactacca gggtcccatt     1440

tgggccaaga ttcctcatac cgatggacac tttcacccct caccgctgat tggtgggttt     1500

gggctgaaac acccgcctcc tcaaattttt atcaagaaca ccccggtacc tgcgaatcct     1560

gcaacgacct tcagctctac tccggtaaac tccttcatta ctcagtacag cactggccag     1620

gtgtcggtgc agattgactg ggagatccag aaggagcggt ccaaacgctg gaaccccgag     1680

gtccagttta cctccaacta cggacagcaa aactctctgt tgtgggctcc cgatgcggct     1740

gggaaataca ctgagcctag ggctatcggt acccgctacc tcacccacca cctgtaataa     1800


<210> 5131
<211> 2208
<212> DNA
<213> Adeno-associated virus 4


<220>
<221> modified_base
<222> (750)..(750)
<223> a, c, t or g

<400> 5131
atgactgacg gttaccttcc agattggcta gaggacaacc tctctgaagg cgttcgagag       60

tggtgggcgc tgcaacctgg agcccctaaa cccaaggcaa atcaacaaca tcaggacaac      120

gctcggggtc ttgtgcttcc gggttacaaa tacctcggac ccggcaacgg actcgacaag      180

ggggaacccg tcaacgcagc ggacgcggca gccctcgagc acgacaaggc ctacgaccag      240

cagctcaagg ccggtgacaa cccctacctc aagtacaacc acgccgacgc ggagttccag      300

cagcggcttc agggcgacac atcgtttggg ggcaacctcg gcagagcagt cttccaggcc      360

aaaaagaggg ttcttgaacc tcttggtctg gttgagcaag cgggtgagac ggctcctgga      420

aagaagagac cgttgattga atccccccag cagcccgact cctccacggg tatcggcaaa      480

aaaggcaagc agccggctaa aaagaagctc gttttcgaag acgaaactgg agcaggcgac      540

ggaccccctg agggatcaac ttccggagcc atgtctgatg acagtgagat gcgtgcagca      600

gctggcggag ctgcagtcga gggsggacaa ggtgccgatg gagtgggtaa tgcctcgggt      660

gattggcatt gcgattccac ctggtctgag ggccacgtca cgaccaccag caccagaacc      720

tgggtcttgc ccacctacaa caaccacctn tacaagcgac tcggagagag cctgcagtcc      780

aacacctaca acggattctc caccccctgg ggatactttg acttcaaccg cttccactgc      840

cacttctcac cacgtgactg gcagcgactc atcaacaaca actggggcat gcgacccaaa      900

gccatgcggg tcaaaatctt caacatccag gtcaaggagg tcacgacgtc gaacggcgag      960

acaacggtgg ctaataacct taccagcacg gttcagatct ttgcggactc gtcgtacgaa     1020

ctgccgtacg tgatggatgc gggtcaagag ggcagcctgc ctccttttcc caacgacgtc     1080

tttatggtgc cccagtacgg ctactgtgga ctggtgaccg gcaacacttc gcagcaacag     1140

actgacagaa atgccttcta ctgcctggag tactttcctt cgcagatgct gcggactggc     1200

aacaactttg aaattacgta cagttttgag aaggtgcctt tccactcgat gtacgcgcac     1260

agccagagcc tggaccggct gatgaaccct ctcatcgacc agtacctgtg gggactgcaa     1320

tcgaccacca ccggaaccac cctgaatgcc gggactgcca ccaccaactt taccaagctg     1380

cggcctacca acttttccaa ctttaaaaag aactggctgc ccgggccttc aatcaagcag     1440

cagggcttct caaagactgc caatcaaaac tacaagatcc ctgccaccgg gtcagacagt     1500

ctcatcaaat acgagacgca cagcactctg gacggaagat ggagtgccct gacccccgga     1560

cctccaatgg ccacggctgg acctgcggac agcaagttca gcaacagcca gctcatcttt     1620

gcggggccta aacagaacgg caacacggcc accgtacccg ggactctgat cttcacctct     1680

gaggaggagc tggcagccac caacgccacc gatacggaca tgtggggcaa cctacctggc     1740

ggtgaccaga gcaacagcaa cctgccgacc gtggacagac tgacagcctt gggagccgtg     1800

cctggaatgg tctggcaaaa cagagacatt tactaccagg gtcccatttg ggccaagatt     1860

cctcataccg atggacactt tcacccctca ccgctgattg gtgggtttgg gctgaaacac     1920

ccgcctcctc aaatttttat caagaacacc ccggtacctg cgaatcctgc aacgaccttc     1980

agctctactc cggtaaactc cttcattact cagtacagca ctggccaggt gtcggtgcag     2040

attgactggg agatccagaa ggagcggtcc aaacgctgga accccgaggt ccagtttacc     2100

tccaactacg gacagcaaaa ctctctgttg tgggctcccg atgcggctgg gaaatacact     2160

gagcctaggg ctatcggtac ccgctacctc acccaccacc tgtaataa                  2208


<210> 5132
<211> 1872
<212> DNA
<213> Adeno-associated virus 4

<400> 5132
atgccggggt tctacgagat cgtgctgaag gtgcccagcg acctggacga gcacctgccc       60

ggcatttctg actcttttgt gagctgggtg gccgagaagg aatgggagct gccgccggat      120

tctgacatgg acttgaatct gattgagcag gcacccctga ccgtggccga aaagctgcaa      180

cgcgagttcc tggtcgagtg gcgccgcgtg agtaaggccc cggaggccct cttctttgtc      240

cagttcgaga agggggacag ctacttccac ctgcacatcc tggtggagac cgtgggcgtc      300

aaatccatgg tggtgggccg ctacgtgagc cagattaaag agaagctggt gacccgcatc      360

taccgcgggg tcgagccgca gcttccgaac tggttcgcgg tgaccaagac gcgtaatggc      420

gccggaggcg ggaacaaggt ggtggacgac tgctacatcc ccaactacct gctccccaag      480

acccagcccg agctccagtg ggcgtggact aacatggacc agtatataag cgcctgtttg      540

aatctcgcgg agcgtaaacg gctggtggcg cagcatctga cgcacgtgtc gcagacgcag      600

gagcagaaca aggaaaacca gaaccccaat tctgacgcgc cggtcatcag gtcaaaaacc      660

tccgccaggt acatggagct ggtcgggtgg ctggtggacc gcgggatcac gtcagaaaag      720

caatggatcc aggaggacca ggcgtcctac atctccttca acgccgcctc caactcgcgg      780

tcacaaatca aggccgcgct ggacaatgcc tccaaaatca tgagcctgac aaagacggct      840

ccggactacc tggtgggcca gaacccgccg gaggacattt ccagcaaccg catctaccga      900

atcctcgaga tgaacgggta cgatccgcag tacgcggcct ccgtcttcct gggctgggcg      960

caaaagaagt tcgggaagag gaacaccatc tggctctttg ggccggccac gacgggtaaa     1020

accaacatcg cggaagccat cgcccacgcc gtgcccttct acggctgcgt gaactggacc     1080

aatgagaact ttccgttcaa cgattgcgtc gacaagatgg tgatctggtg ggaggagggc     1140

aagatgacgg ccaaggtcgt agagagcgcc aaggccatcc tgggcggaag caaggtgcgc     1200

gtggaccaaa agtgcaagtc atcggcccag atcgacccaa ctcccgtgat cgtcacctcc     1260

aacaccaaca tgtgcgcggt catcgacgga aactcgacca ccttcgagca ccaacaacca     1320

ctccaggacc ggatgttcaa gttcgagctc accaagcgcc tggagcacga ctttggcaag     1380

gtcaccaagc aggaagtcaa agactttttc cggtgggcgt cagatcacgt gaccgaggtg     1440

actcacgagt tttacgtcag aaagggtgga gctagaaaga ggcccgcccc caatgacgca     1500

gatataagtg agcccaagcg ggcctgtccg tcagttgcgc agccatcgac gtcagacgcg     1560

gaagctccgg tggactacgc ggacaggtac caaaacaaat gttctcgtca cgtgggtatg     1620

aatctgatgc tttttccctg ccggcaatgc gagagaatga atcagaatgt ggacatttgc     1680

ttcacgcacg gggtcatgga ctgtgccgag tgcttccccg tgtcagaatc tcaacccgtg     1740

tctgtcgtca gaaagcggac gtatcagaaa ctgtgtccga ttcatcacat catggggagg     1800

gcgcccgagg tggcctgctc ggcctgcgaa ctggccaatg tggacttgga tgactgtgac     1860

atggaacaat aa                                                         1872


<210> 5133
<211> 1611
<212> DNA
<213> Adeno-associated virus 4

<400> 5133
atgccggggt tctacgagat cgtgctgaag gtgcccagcg acctggacga gcacctgccc       60

ggcatttctg actcttttgt gagctgggtg gccgagaagg aatgggagct gccgccggat      120

tctgacatgg acttgaatct gattgagcag gcacccctga ccgtggccga aaagctgcaa      180

cgcgagttcc tggtcgagtg gcgccgcgtg agtaaggccc cggaggccct cttctttgtc      240

cagttcgaga agggggacag ctacttccac ctgcacatcc tggtggagac cgtgggcgtc      300

aaatccatgg tggtgggccg ctacgtgagc cagattaaag agaagctggt gacccgcatc      360

taccgcgggg tcgagccgca gcttccgaac tggttcgcgg tgaccaagac gcgtaatggc      420

gccggaggcg ggaacaaggt ggtggacgac tgctacatcc ccaactacct gctccccaag      480

acccagcccg agctccagtg ggcgtggact aacatggacc agtatataag cgcctgtttg      540

aatctcgcgg agcgtaaacg gctggtggcg cagcatctga cgcacgtgtc gcagacgcag      600

gagcagaaca aggaaaacca gaaccccaat tctgacgcgc cggtcatcag gtcaaaaacc      660

tccgccaggt acatggagct ggtcgggtgg ctggtggacc gcgggatcac gtcagaaaag      720

caatggatcc aggaggacca ggcgtcctac atctccttca acgccgcctc caactcgcgg      780

tcacaaatca aggccgcgct ggacaatgcc tccaaaatca tgagcctgac aaagacggct      840

ccggactacc tggtgggcca gaacccgccg gaggacattt ccagcaaccg catctaccga      900

atcctcgaga tgaacgggta cgatccgcag tacgcggcct ccgtcttcct gggctgggcg      960

caaaagaagt tcgggaagag gaacaccatc tggctctttg ggccggccac gacgggtaaa     1020

accaacatcg cggaagccat cgcccacgcc gtgcccttct acggctgcgt gaactggacc     1080

aatgagaact ttccgttcaa cgattgcgtc gacaagatgg tgatctggtg ggaggagggc     1140

aagatgacgg ccaaggtcgt agagagcgcc aaggccatcc tgggcggaag caaggtgcgc     1200

gtggaccaaa agtgcaagtc atcggcccag atcgacccaa ctcccgtgat cgtcacctcc     1260

aacaccaaca tgtgcgcggt catcgacgga aactcgacca ccttcgagca ccaacaacca     1320

ctccaggacc ggatgttcaa gttcgagctc accaagcgcc tggagcacga ctttggcaag     1380

gtcaccaagc aggaagtcaa agactttttc cggtgggcgt cagatcacgt gaccgaggtg     1440

actcacgagt tttacgtcag aaagggtgga gctagaaaga ggcccgcccc caatgacgca     1500

gatataagtg agcccaagcg ggcctgtccg tcagttgcgc agccatcgac gtcagacgcg     1560

gaagctccgg tggactacgc ggacagattg gctagaggac aacctctctg a              1611


<210> 5134
<211> 1872
<212> DNA
<213> Adeno-associated virus 4

<400> 5134
atgccggggt tctacgagat cgtgctgaag gtgcccagcg acctggacga gcacctgccc       60

ggcatttctg actcttttgt gagctgggtg gccgagaagg aatgggagct gccgccggat      120

tctgacatgg acttgaatct gattgagcag gcacccctga ccgtggccga aaagctgcaa      180

cgcgagttcc tggtcgagtg gcgccgcgtg agtaaggccc cggaggccct cttctttgtc      240

cagttcgaga agggggacag ctacttccac ctgcacatcc tggtggagac cgtgggcgtc      300

aaatccatgg tggtgggccg ctacgtgagc cagattaaag agaagctggt gacccgcatc      360

taccgcgggg tcgagccgca gcttccgaac tggttcgcgg tgaccaagac gcgtaatggc      420

gccggaggcg ggaacaaggt ggtggacgac tgctacatcc ccaactacct gctccccaag      480

acccagcccg agctccagtg ggcgtggact aacatggacc agtatataag cgcctgtttg      540

aatctcgcgg agcgtaaacg gctggtggcg cagcatctga cgcacgtgtc gcagacgcag      600

gagcagaaca aggaaaacca gaaccccaat tctgacgcgc cggtcatcag gtcaaaaacc      660

tccgccaggt acatggagct ggtcgggtgg ctggtggacc gcgggatcac gtcagaaaag      720

caatggatcc aggaggacca ggcgtcctac atctccttca acgccgcctc caactcgcgg      780

tcacaaatca aggccgcgct ggacaatgcc tccaaaatca tgagcctgac aaagacggct      840

ccggactacc tggtgggcca gaacccgccg gaggacattt ccagcaaccg catctaccga      900

atcctcgaga tgaacgggta cgatccgcag tacgcggcct ccgtcttcct gggctgggcg      960

caaaagaagt tcgggaagag gaacaccatc tggctctttg ggccggccac gacgggtaaa     1020

accaacatcg cggaagccat cgcccacgcc gtgcccttct acggctgcgt gaactggacc     1080

aatgagaact ttccgttcaa cgattgcgtc gacaagatgg tgatctggtg ggaggagggc     1140

aagatgacgg ccaaggtcgt agagagcgcc aaggccatcc tgggcggaag caaggtgcgc     1200

gtggaccaaa agtgcaagtc atcggcccag atcgacccaa ctcccgtgat cgtcacctcc     1260

aacaccaaca tgtgcgcggt catcgacgga aactcgacca ccttcgagca ccaacaacca     1320

ctccaggacc ggatgttcaa gttcgagctc accaagcgcc tggagcacga ctttggcaag     1380

gtcaccaagc aggaagtcaa agactttttc cggtgggcgt cagatcacgt gaccgaggtg     1440

actcacgagt tttacgtcag aaagggtgga gctagaaaga ggcccgcccc caatgacgca     1500

gatataagtg agcccaagcg ggcctgtccg tcagttgcgc agccatcgac gtcagacgcg     1560

gaagctccgg tggactacgc ggacaggtac caaaacaaat gttctcgtca cgtgggtatg     1620

aatctgatgc tttttccctg ccggcaatgc gagagaatga atcagaatgt ggacatttgc     1680

ttcacgcacg gggtcatgga ctgtgccgag tgcttccccg tgtcagaatc tcaacccgtg     1740

tctgtcgtca gaaagcggac gtatcagaaa ctgtgtccga ttcatcacat catggggagg     1800

gcgcccgagg tggcctgctc ggcctgcgaa ctggccaatg tggacttgga tgactgtgac     1860

atggaacaat aa                                                         1872


<210> 5135
<211> 1617
<212> DNA
<213> Adeno-associated virus 4


<220>
<221> modified_base
<222> (162)..(162)
<223> a, c, t or g

<400> 5135
atgcgtgcag cagctggcgg agctgcagtc gagggsggac aaggtgccga tggagtgggt       60

aatgcctcgg gtgattggca ttgcgattcc acctggtctg agggccacgt cacgaccacc      120

agcaccagaa cctgggtctt gcccacctac aacaaccacc tntacaagcg actcggagag      180

agcctgcagt ccaacaccta caacggattc tccaccccct ggggatactt tgacttcaac      240

cgcttccact gccacttctc accacgtgac tggcagcgac tcatcaacaa caactggggc      300

atgcgaccca aagccatgcg ggtcaaaatc ttcaacatcc aggtcaagga ggtcacgacg      360

tcgaacggcg agacaacggt ggctaataac cttaccagca cggttcagat ctttgcggac      420

tcgtcgtacg aactgccgta cgtgatggat gcgggtcaag agggcagcct gcctcctttt      480

cccaacgacg tctttatggt gccccagtac ggctactgtg gactggtgac cggcaacact      540

tcgcagcaac agactgacag aaatgccttc tactgcctgg agtactttcc ttcgcagatg      600

ctgcggactg gcaacaactt tgaaattacg tacagttttg agaaggtgcc tttccactcg      660

atgtacgcgc acagccagag cctggaccgg ctgatgaacc ctctcatcga ccagtacctg      720

tggggactgc aatcgaccac caccggaacc accctgaatg ccgggactgc caccaccaac      780

tttaccaagc tgcggcctac caacttttcc aactttaaaa agaactggct gcccgggcct      840

tcaatcaagc agcagggctt ctcaaagact gccaatcaaa actacaagat ccctgccacc      900

gggtcagaca gtctcatcaa atacgagacg cacagcactc tggacggaag atggagtgcc      960

ctgacccccg gacctccaat ggccacggct ggacctgcgg acagcaagtt cagcaacagc     1020

cagctcatct ttgcggggcc taaacagaac ggcaacacgg ccaccgtacc cgggactctg     1080

atcttcacct ctgaggagga gctggcagcc accaacgcca ccgatacgga catgtggggc     1140

aacctacctg gcggtgacca gagcaacagc aacctgccga ccgtggacag actgacagcc     1200

ttgggagccg tgcctggaat ggtctggcaa aacagagaca tttactacca gggtcccatt     1260

tgggccaaga ttcctcatac cgatggacac tttcacccct caccgctgat tggtgggttt     1320

gggctgaaac acccgcctcc tcaaattttt atcaagaaca ccccggtacc tgcgaatcct     1380

gcaacgacct tcagctctac tccggtaaac tccttcatta ctcagtacag cactggccag     1440

gtgtcggtgc agattgactg ggagatccag aaggagcggt ccaaacgctg gaaccccgag     1500

gtccagttta cctccaacta cggacagcaa aactctctgt tgtgggctcc cgatgcggct     1560

gggaaataca ctgagcctag ggctatcggt acccgctacc tcacccacca cctgtaa        1617


<210> 5136
<211> 939
<212> DNA
<213> Adeno-associated virus 4

<400> 5136
atggagctgg tcgggtggct ggtggaccgc gggatcacgt cagaaaagca atggatccag       60

gaggaccagg cgtcctacat ctccttcaac gccgcctcca actcgcggtc acaaatcaag      120

gccgcgctgg acaatgcctc caaaatcatg agcctgacaa agacggctcc ggactacctg      180

gtgggccaga acccgccgga ggacatttcc agcaaccgca tctaccgaat cctcgagatg      240

aacgggtacg atccgcagta cgcggcctcc gtcttcctgg gctgggcgca aaagaagttc      300

gggaagagga acaccatctg gctctttggg ccggccacga cgggtaaaac caacatcgcg      360

gaagccatcg cccacgccgt gcccttctac ggctgcgtga actggaccaa tgagaacttt      420

ccgttcaacg attgcgtcga caagatggtg atctggtggg aggagggcaa gatgacggcc      480

aaggtcgtag agagcgccaa ggccatcctg ggcggaagca aggtgcgcgt ggaccaaaag      540

tgcaagtcat cggcccagat cgacccaact cccgtgatcg tcacctccaa caccaacatg      600

tgcgcggtca tcgacggaaa ctcgaccacc ttcgagcacc aacaaccact ccaggaccgg      660

atgttcaagt tcgagctcac caagcgcctg gagcacgact ttggcaaggt caccaagcag      720

gaagtcaaag actttttccg gtgggcgtca gatcacgtga ccgaggtgac tcacgagttt      780

tacgtcagaa agggtggagc tagaaagagg cccgccccca atgacgcaga tataagtgag      840

cccaagcggg cctgtccgtc agttgcgcag ccatcgacgt cagacgcgga agctccggtg      900

gactacgcgg acagattggc tagaggacaa cctctctga                             939


<210> 5137
<211> 1197
<212> DNA
<213> Adeno-associated virus 4

<400> 5137
atggagctgg tcgggtggct ggtggaccgc gggatcacgt cagaaaagca atggatccag       60

gaggaccagg cgtcctacat ctccttcaac gccgcctcca actcgcggtc acaaatcaag      120

gccgcgctgg acaatgcctc caaaatcatg agcctgacaa agacggctcc ggactacctg      180

gtgggccaga acccgccgga ggacatttcc agcaaccgca tctaccgaat cctcgagatg      240

aacgggtacg atccgcagta cgcggcctcc gtcttcctgg gctgggcgca aaagaagttc      300

gggaagagga acaccatctg gctctttggg ccggccacga cgggtaaaac caacatcgcg      360

gaagccatcg cccacgccgt gcccttctac ggctgcgtga actggaccaa tgagaacttt      420

ccgttcaacg attgcgtcga caagatggtg atctggtggg aggagggcaa gatgacggcc      480

aaggtcgtag agagcgccaa ggccatcctg ggcggaagca aggtgcgcgt ggaccaaaag      540

tgcaagtcat cggcccagat cgacccaact cccgtgatcg tcacctccaa caccaacatg      600

tgcgcggtca tcgacggaaa ctcgaccacc ttcgagcacc aacaaccact ccaggaccgg      660

atgttcaagt tcgagctcac caagcgcctg gagcacgact ttggcaaggt caccaagcag      720

gaagtcaaag actttttccg gtgggcgtca gatcacgtga ccgaggtgac tcacgagttt      780

tacgtcagaa agggtggagc tagaaagagg cccgccccca atgacgcaga tataagtgag      840

cccaagcggg cctgtccgtc agttgcgcag ccatcgacgt cagacgcgga agctccggtg      900

gactacgcgg acaggtacca aaacaaatgt tctcgtcacg tgggtatgaa tctgatgctt      960

tttccctgcc ggcaatgcga gagaatgaat cagaatgtgg acatttgctt cacgcacggg     1020

gtcatggact gtgccgagtg cttccccgtg tcagaatctc aacccgtgtc tgtcgtcaga     1080

aagcggacgt atcagaaact gtgtccgatt catcacatca tggggagggc gcccgaggtg     1140

gcctgctcgg cctgcgaact ggccaatgtg gacttggatg actgtgacat ggaacaa        1197


<210> 5138
<211> 245
<212> DNA
<213> Adeno-associated virus 4

<400> 5138
ctccatcatc taggtttgcc cactgacgtc aatgtgacgt cctagggtta gggaggtccc       60

tgtattagca gtcacgtgag tgtcgtattt cgcggagcgt agcggagcgc ataccaagct      120

gccacgtcac agccacgtgg tccgtttgcg acagtttgcg acaccatgtg gtcaggaggg      180

tatataaccg cgagtgagcc agcgaggagc tccattttgc ccgcgaattt tgaacgagca      240

gcagc                                                                  245


<210> 5139
<211> 313
<212> PRT
<213> Adeno-associated virus 4


<220>
<221> MOD_RES
<222> (313)..(313)
<223> Any amino acid

<400> 5139
Met Glu Leu Val Gly Trp Leu Val Asp Arg Gly Ile Thr Ser Glu Lys 
1               5                   10                  15      


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
            20                  25                  30          


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Ser Lys 
        35                  40                  45              


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Asn 
    50                  55                  60                  


Pro Pro Glu Asp Ile Ser Ser Asn Arg Ile Tyr Arg Ile Leu Glu Met 
65                  70                  75                  80  


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
                85                  90                  95      


Gln Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
            100                 105                 110         


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Ala Val Pro 
        115                 120                 125             


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
    130                 135                 140                 


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
145                 150                 155                 160 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
                165                 170                 175     


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
            180                 185                 190         


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
        195                 200                 205             


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
    210                 215                 220                 


Glu Leu Thr Lys Arg Leu Glu His Asp Phe Gly Lys Val Thr Lys Gln 
225                 230                 235                 240 


Glu Val Lys Asp Phe Phe Arg Trp Ala Ser Asp His Val Thr Glu Val 
                245                 250                 255     


Thr His Glu Phe Tyr Val Arg Lys Gly Gly Ala Arg Lys Arg Pro Ala 
            260                 265                 270         


Pro Asn Asp Ala Asp Ile Ser Glu Pro Lys Arg Ala Cys Pro Ser Val 
        275                 280                 285             


Ala Gln Pro Ser Thr Ser Asp Ala Glu Ala Pro Val Asp Tyr Ala Asp 
    290                 295                 300                 


Arg Leu Ala Arg Gly Gln Pro Leu Xaa 
305                 310             


<210> 5140
<211> 399
<212> PRT
<213> Adeno-associated virus 4

<400> 5140
Met Glu Leu Val Gly Trp Leu Val Asp Arg Gly Ile Thr Ser Glu Lys 
1               5                   10                  15      


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
            20                  25                  30          


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Ser Lys 
        35                  40                  45              


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Asn 
    50                  55                  60                  


Pro Pro Glu Asp Ile Ser Ser Asn Arg Ile Tyr Arg Ile Leu Glu Met 
65                  70                  75                  80  


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
                85                  90                  95      


Gln Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
            100                 105                 110         


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Ala Val Pro 
        115                 120                 125             


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
    130                 135                 140                 


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
145                 150                 155                 160 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
                165                 170                 175     


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
            180                 185                 190         


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
        195                 200                 205             


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
    210                 215                 220                 


Glu Leu Thr Lys Arg Leu Glu His Asp Phe Gly Lys Val Thr Lys Gln 
225                 230                 235                 240 


Glu Val Lys Asp Phe Phe Arg Trp Ala Ser Asp His Val Thr Glu Val 
                245                 250                 255     


Thr His Glu Phe Tyr Val Arg Lys Gly Gly Ala Arg Lys Arg Pro Ala 
            260                 265                 270         


Pro Asn Asp Ala Asp Ile Ser Glu Pro Lys Arg Ala Cys Pro Ser Val 
        275                 280                 285             


Ala Gln Pro Ser Thr Ser Asp Ala Glu Ala Pro Val Asp Tyr Ala Asp 
    290                 295                 300                 


Arg Tyr Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu 
305                 310                 315                 320 


Phe Pro Cys Arg Gln Cys Glu Arg Met Asn Gln Asn Val Asp Ile Cys 
                325                 330                 335     


Phe Thr His Gly Val Met Asp Cys Ala Glu Cys Phe Pro Val Ser Glu 
            340                 345                 350         


Ser Gln Pro Val Ser Val Val Arg Lys Arg Thr Tyr Gln Lys Leu Cys 
        355                 360                 365             


Pro Ile His His Ile Met Gly Arg Ala Pro Glu Val Ala Cys Ser Ala 
    370                 375                 380                 


Cys Glu Leu Ala Asn Val Asp Leu Asp Asp Cys Asp Met Glu Gln 
385                 390                 395                 


<210> 5141
<211> 623
<212> PRT
<213> Adeno-associated virus 4

<400> 5141
Met Pro Gly Phe Tyr Glu Ile Val Leu Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Glu His Leu Pro Gly Ile Ser Asp Ser Phe Val Ser Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Glu Phe Leu 
    50                  55                  60                  


Val Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Asp Ser Tyr Phe His Leu His Ile Leu Val Glu 
                85                  90                  95      


Thr Val Gly Val Lys Ser Met Val Val Gly Arg Tyr Val Ser Gln Ile 
            100                 105                 110         


Lys Glu Lys Leu Val Thr Arg Ile Tyr Arg Gly Val Glu Pro Gln Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Asp Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Asp Gln Tyr Ile 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Ala Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Arg Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Ser Lys 
            260                 265                 270         


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Asn 
        275                 280                 285             


Pro Pro Glu Asp Ile Ser Ser Asn Arg Ile Tyr Arg Ile Leu Glu Met 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Gln Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Ala Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
        435                 440                 445             


Glu Leu Thr Lys Arg Leu Glu His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Asp Phe Phe Arg Trp Ala Ser Asp His Val Thr Glu Val 
465                 470                 475                 480 


Thr His Glu Phe Tyr Val Arg Lys Gly Gly Ala Arg Lys Arg Pro Ala 
                485                 490                 495     


Pro Asn Asp Ala Asp Ile Ser Glu Pro Lys Arg Ala Cys Pro Ser Val 
            500                 505                 510         


Ala Gln Pro Ser Thr Ser Asp Ala Glu Ala Pro Val Asp Tyr Ala Asp 
        515                 520                 525             


Arg Tyr Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu 
    530                 535                 540                 


Phe Pro Cys Arg Gln Cys Glu Arg Met Asn Gln Asn Val Asp Ile Cys 
545                 550                 555                 560 


Phe Thr His Gly Val Met Asp Cys Ala Glu Cys Phe Pro Val Ser Glu 
                565                 570                 575     


Ser Gln Pro Val Ser Val Val Arg Lys Arg Thr Tyr Gln Lys Leu Cys 
            580                 585                 590         


Pro Ile His His Ile Met Gly Arg Ala Pro Glu Val Ala Cys Ser Ala 
        595                 600                 605             


Cys Glu Leu Ala Asn Val Asp Leu Asp Asp Cys Asp Met Glu Gln 
    610                 615                 620             


<210> 5142
<211> 537
<212> PRT
<213> Adeno-associated virus 4


<220>
<221> MOD_RES
<222> (537)..(537)
<223> Any amino acid

<400> 5142
Met Pro Gly Phe Tyr Glu Ile Val Leu Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Glu His Leu Pro Gly Ile Ser Asp Ser Phe Val Ser Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Glu Phe Leu 
    50                  55                  60                  


Val Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Asp Ser Tyr Phe His Leu His Ile Leu Val Glu 
                85                  90                  95      


Thr Val Gly Val Lys Ser Met Val Val Gly Arg Tyr Val Ser Gln Ile 
            100                 105                 110         


Lys Glu Lys Leu Val Thr Arg Ile Tyr Arg Gly Val Glu Pro Gln Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Asp Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Asp Gln Tyr Ile 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Ala Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Arg Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Ser Lys 
            260                 265                 270         


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Asn 
        275                 280                 285             


Pro Pro Glu Asp Ile Ser Ser Asn Arg Ile Tyr Arg Ile Leu Glu Met 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Gln Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Ala Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
        435                 440                 445             


Glu Leu Thr Lys Arg Leu Glu His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Asp Phe Phe Arg Trp Ala Ser Asp His Val Thr Glu Val 
465                 470                 475                 480 


Thr His Glu Phe Tyr Val Arg Lys Gly Gly Ala Arg Lys Arg Pro Ala 
                485                 490                 495     


Pro Asn Asp Ala Asp Ile Ser Glu Pro Lys Arg Ala Cys Pro Ser Val 
            500                 505                 510         


Ala Gln Pro Ser Thr Ser Asp Ala Glu Ala Pro Val Asp Tyr Ala Asp 
        515                 520                 525             


Arg Leu Ala Arg Gly Gln Pro Leu Xaa 
    530                 535         


<210> 5143
<211> 623
<212> PRT
<213> Adeno-associated virus 4

<400> 5143
Met Pro Gly Phe Tyr Glu Ile Val Leu Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Glu His Leu Pro Gly Ile Ser Asp Ser Phe Val Ser Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Glu Phe Leu 
    50                  55                  60                  


Val Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Asp Ser Tyr Phe His Leu His Ile Leu Val Glu 
                85                  90                  95      


Thr Val Gly Val Lys Ser Met Val Val Gly Arg Tyr Val Ser Gln Ile 
            100                 105                 110         


Lys Glu Lys Leu Val Thr Arg Ile Tyr Arg Gly Val Glu Pro Gln Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Asp Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Asp Gln Tyr Ile 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Ala Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Arg Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Ser Lys 
            260                 265                 270         


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Asn 
        275                 280                 285             


Pro Pro Glu Asp Ile Ser Ser Asn Arg Ile Tyr Arg Ile Leu Glu Met 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Gln Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Ala Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
        435                 440                 445             


Glu Leu Thr Lys Arg Leu Glu His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Asp Phe Phe Arg Trp Ala Ser Asp His Val Thr Glu Val 
465                 470                 475                 480 


Thr His Glu Phe Tyr Val Arg Lys Gly Gly Ala Arg Lys Arg Pro Ala 
                485                 490                 495     


Pro Asn Asp Ala Asp Ile Ser Glu Pro Lys Arg Ala Cys Pro Ser Val 
            500                 505                 510         


Ala Gln Pro Ser Thr Ser Asp Ala Glu Ala Pro Val Asp Tyr Ala Asp 
        515                 520                 525             


Arg Tyr Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu 
    530                 535                 540                 


Phe Pro Cys Arg Gln Cys Glu Arg Met Asn Gln Asn Val Asp Ile Cys 
545                 550                 555                 560 


Phe Thr His Gly Val Met Asp Cys Ala Glu Cys Phe Pro Val Ser Glu 
                565                 570                 575     


Ser Gln Pro Val Ser Val Val Arg Lys Arg Thr Tyr Gln Lys Leu Cys 
            580                 585                 590         


Pro Ile His His Ile Met Gly Arg Ala Pro Glu Val Ala Cys Ser Ala 
        595                 600                 605             


Cys Glu Leu Ala Asn Val Asp Leu Asp Asp Cys Asp Met Glu Gln 
    610                 615                 620             


<210> 5144
<211> 544
<212> PRT
<213> Adeno-associated virus 4

<400> 5144
Met Ser Asp Asp Ser Glu Met Arg Ala Ala Ala Gly Gly Ala Ala Val 
1               5                   10                  15      


Glu Gly Gly Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp Trp 
            20                  25                  30          


His Cys Asp Ser Thr Trp Ser Glu Gly His Val Thr Thr Thr Ser Thr 
        35                  40                  45              


Arg Thr Trp Val Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Arg Leu 
    50                  55                  60                  


Gly Glu Ser Leu Gln Ser Asn Thr Tyr Asn Gly Phe Ser Thr Pro Trp 
65                  70                  75                  80  


Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp 
                85                  90                  95      


Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Met Arg Pro Lys Ala Met 
            100                 105                 110         


Arg Val Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Thr Ser Asn 
        115                 120                 125             


Gly Glu Thr Thr Val Ala Asn Asn Leu Thr Ser Thr Val Gln Ile Phe 
    130                 135                 140                 


Ala Asp Ser Ser Tyr Glu Leu Pro Tyr Val Met Asp Ala Gly Gln Glu 
145                 150                 155                 160 


Gly Ser Leu Pro Pro Phe Pro Asn Asp Val Phe Met Val Pro Gln Tyr 
                165                 170                 175     


Gly Tyr Cys Gly Leu Val Thr Gly Asn Thr Ser Gln Gln Gln Thr Asp 
            180                 185                 190         


Arg Asn Ala Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
        195                 200                 205             


Thr Gly Asn Asn Phe Glu Ile Thr Tyr Ser Phe Glu Lys Val Pro Phe 
    210                 215                 220                 


His Ser Met Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
225                 230                 235                 240 


Leu Ile Asp Gln Tyr Leu Trp Gly Leu Gln Ser Thr Thr Thr Gly Thr 
                245                 250                 255     


Thr Leu Asn Ala Gly Thr Ala Thr Thr Asn Phe Thr Lys Leu Arg Pro 
            260                 265                 270         


Thr Asn Phe Ser Asn Phe Lys Lys Asn Trp Leu Pro Gly Pro Ser Ile 
        275                 280                 285             


Lys Gln Gln Gly Phe Ser Lys Thr Ala Asn Gln Asn Tyr Lys Ile Pro 
    290                 295                 300                 


Ala Thr Gly Ser Asp Ser Leu Ile Lys Tyr Glu Thr His Ser Thr Leu 
305                 310                 315                 320 


Asp Gly Arg Trp Ser Ala Leu Thr Pro Gly Pro Pro Met Ala Thr Ala 
                325                 330                 335     


Gly Pro Ala Asp Ser Lys Phe Ser Asn Ser Gln Leu Ile Phe Ala Gly 
            340                 345                 350         


Pro Lys Gln Asn Gly Asn Thr Ala Thr Val Pro Gly Thr Leu Ile Phe 
        355                 360                 365             


Thr Ser Glu Glu Glu Leu Ala Ala Thr Asn Ala Thr Asp Thr Asp Met 
    370                 375                 380                 


Trp Gly Asn Leu Pro Gly Gly Asp Gln Ser Asn Ser Asn Leu Pro Thr 
385                 390                 395                 400 


Val Asp Arg Leu Thr Ala Leu Gly Ala Val Pro Gly Met Val Trp Gln 
                405                 410                 415     


Asn Arg Asp Ile Tyr Tyr Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
            420                 425                 430         


Thr Asp Gly His Phe His Pro Ser Pro Leu Ile Gly Gly Phe Gly Leu 
        435                 440                 445             


Lys His Pro Pro Pro Gln Ile Phe Ile Lys Asn Thr Pro Val Pro Ala 
    450                 455                 460                 


Asn Pro Ala Thr Thr Phe Ser Ser Thr Pro Val Asn Ser Phe Ile Thr 
465                 470                 475                 480 


Gln Tyr Ser Thr Gly Gln Val Ser Val Gln Ile Asp Trp Glu Ile Gln 
                485                 490                 495     


Lys Glu Arg Ser Lys Arg Trp Asn Pro Glu Val Gln Phe Thr Ser Asn 
            500                 505                 510         


Tyr Gly Gln Gln Asn Ser Leu Leu Trp Ala Pro Asp Ala Ala Gly Lys 
        515                 520                 525             


Tyr Thr Glu Pro Arg Ala Ile Gly Thr Arg Tyr Leu Thr His His Leu 
    530                 535                 540                 


<210> 5145
<211> 734
<212> PRT
<213> Adeno-associated virus 4

<400> 5145
Met Thr Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser Glu 
1               5                   10                  15      


Gly Val Arg Glu Trp Trp Ala Leu Gln Pro Gly Ala Pro Lys Pro Lys 
            20                  25                  30          


Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro Val 
    50                  55                  60                  


Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp Gln 
65                  70                  75                  80  


Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Gln Arg Leu Gln Gly Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Leu 
        115                 120                 125             


Gly Leu Val Glu Gln Ala Gly Glu Thr Ala Pro Gly Lys Lys Arg Pro 
    130                 135                 140                 


Leu Ile Glu Ser Pro Gln Gln Pro Asp Ser Ser Thr Gly Ile Gly Lys 
145                 150                 155                 160 


Lys Gly Lys Gln Pro Ala Lys Lys Lys Leu Val Phe Glu Asp Glu Thr 
                165                 170                 175     


Gly Ala Gly Asp Gly Pro Pro Glu Gly Ser Thr Ser Gly Ala Met Ser 
            180                 185                 190         


Asp Asp Ser Glu Met Arg Ala Ala Ala Gly Gly Ala Ala Val Glu Gly 
        195                 200                 205             


Gly Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys 
    210                 215                 220                 


Asp Ser Thr Trp Ser Glu Gly His Val Thr Thr Thr Ser Thr Arg Thr 
225                 230                 235                 240 


Trp Val Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Arg Leu Gly Glu 
                245                 250                 255     


Ser Leu Gln Ser Asn Thr Tyr Asn Gly Phe Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Asn Trp Gly Met Arg Pro Lys Ala Met Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Thr Ser Asn Gly Glu 
305                 310                 315                 320 


Thr Thr Val Ala Asn Asn Leu Thr Ser Thr Val Gln Ile Phe Ala Asp 
                325                 330                 335     


Ser Ser Tyr Glu Leu Pro Tyr Val Met Asp Ala Gly Gln Glu Gly Ser 
            340                 345                 350         


Leu Pro Pro Phe Pro Asn Asp Val Phe Met Val Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Cys Gly Leu Val Thr Gly Asn Thr Ser Gln Gln Gln Thr Asp Arg Asn 
    370                 375                 380                 


Ala Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly 
385                 390                 395                 400 


Asn Asn Phe Glu Ile Thr Tyr Ser Phe Glu Lys Val Pro Phe His Ser 
                405                 410                 415     


Met Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile 
            420                 425                 430         


Asp Gln Tyr Leu Trp Gly Leu Gln Ser Thr Thr Thr Gly Thr Thr Leu 
        435                 440                 445             


Asn Ala Gly Thr Ala Thr Thr Asn Phe Thr Lys Leu Arg Pro Thr Asn 
    450                 455                 460                 


Phe Ser Asn Phe Lys Lys Asn Trp Leu Pro Gly Pro Ser Ile Lys Gln 
465                 470                 475                 480 


Gln Gly Phe Ser Lys Thr Ala Asn Gln Asn Tyr Lys Ile Pro Ala Thr 
                485                 490                 495     


Gly Ser Asp Ser Leu Ile Lys Tyr Glu Thr His Ser Thr Leu Asp Gly 
            500                 505                 510         


Arg Trp Ser Ala Leu Thr Pro Gly Pro Pro Met Ala Thr Ala Gly Pro 
        515                 520                 525             


Ala Asp Ser Lys Phe Ser Asn Ser Gln Leu Ile Phe Ala Gly Pro Lys 
    530                 535                 540                 


Gln Asn Gly Asn Thr Ala Thr Val Pro Gly Thr Leu Ile Phe Thr Ser 
545                 550                 555                 560 


Glu Glu Glu Leu Ala Ala Thr Asn Ala Thr Asp Thr Asp Met Trp Gly 
                565                 570                 575     


Asn Leu Pro Gly Gly Asp Gln Ser Asn Ser Asn Leu Pro Thr Val Asp 
            580                 585                 590         


Arg Leu Thr Ala Leu Gly Ala Val Pro Gly Met Val Trp Gln Asn Arg 
        595                 600                 605             


Asp Ile Tyr Tyr Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp 
    610                 615                 620                 


Gly His Phe His Pro Ser Pro Leu Ile Gly Gly Phe Gly Leu Lys His 
625                 630                 635                 640 


Pro Pro Pro Gln Ile Phe Ile Lys Asn Thr Pro Val Pro Ala Asn Pro 
                645                 650                 655     


Ala Thr Thr Phe Ser Ser Thr Pro Val Asn Ser Phe Ile Thr Gln Tyr 
            660                 665                 670         


Ser Thr Gly Gln Val Ser Val Gln Ile Asp Trp Glu Ile Gln Lys Glu 
        675                 680                 685             


Arg Ser Lys Arg Trp Asn Pro Glu Val Gln Phe Thr Ser Asn Tyr Gly 
    690                 695                 700                 


Gln Gln Asn Ser Leu Leu Trp Ala Pro Asp Ala Ala Gly Lys Tyr Thr 
705                 710                 715                 720 


Glu Pro Arg Ala Ile Gly Thr Arg Tyr Leu Thr His His Leu 
                725                 730                 


<210> 5146
<211> 598
<212> PRT
<213> Adeno-associated virus 4

<400> 5146
Thr Ala Pro Gly Lys Lys Arg Pro Leu Ile Glu Ser Pro Gln Gln Pro 
1               5                   10                  15      


Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Lys Gln Pro Ala Lys Lys 
            20                  25                  30          


Lys Leu Val Phe Glu Asp Glu Thr Gly Ala Gly Asp Gly Pro Pro Glu 
        35                  40                  45              


Gly Ser Thr Ser Gly Ala Met Ser Asp Asp Ser Glu Met Arg Ala Ala 
    50                  55                  60                  


Ala Gly Gly Ala Ala Val Glu Gly Gly Gln Gly Ala Asp Gly Val Gly 
65                  70                  75                  80  


Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp Ser Glu Gly His 
                85                  90                  95      


Val Thr Thr Thr Ser Thr Arg Thr Trp Val Leu Pro Thr Tyr Asn Asn 
            100                 105                 110         


His Leu Tyr Lys Arg Leu Gly Glu Ser Leu Gln Ser Asn Thr Tyr Asn 
        115                 120                 125             


Gly Phe Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys 
    130                 135                 140                 


His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly 
145                 150                 155                 160 


Met Arg Pro Lys Ala Met Arg Val Lys Ile Phe Asn Ile Gln Val Lys 
                165                 170                 175     


Glu Val Thr Thr Ser Asn Gly Glu Thr Thr Val Ala Asn Asn Leu Thr 
            180                 185                 190         


Ser Thr Val Gln Ile Phe Ala Asp Ser Ser Tyr Glu Leu Pro Tyr Val 
        195                 200                 205             


Met Asp Ala Gly Gln Glu Gly Ser Leu Pro Pro Phe Pro Asn Asp Val 
    210                 215                 220                 


Phe Met Val Pro Gln Tyr Gly Tyr Cys Gly Leu Val Thr Gly Asn Thr 
225                 230                 235                 240 


Ser Gln Gln Gln Thr Asp Arg Asn Ala Phe Tyr Cys Leu Glu Tyr Phe 
                245                 250                 255     


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Ile Thr Tyr Ser 
            260                 265                 270         


Phe Glu Lys Val Pro Phe His Ser Met Tyr Ala His Ser Gln Ser Leu 
        275                 280                 285             


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Trp Gly Leu Gln 
    290                 295                 300                 


Ser Thr Thr Thr Gly Thr Thr Leu Asn Ala Gly Thr Ala Thr Thr Asn 
305                 310                 315                 320 


Phe Thr Lys Leu Arg Pro Thr Asn Phe Ser Asn Phe Lys Lys Asn Trp 
                325                 330                 335     


Leu Pro Gly Pro Ser Ile Lys Gln Gln Gly Phe Ser Lys Thr Ala Asn 
            340                 345                 350         


Gln Asn Tyr Lys Ile Pro Ala Thr Gly Ser Asp Ser Leu Ile Lys Tyr 
        355                 360                 365             


Glu Thr His Ser Thr Leu Asp Gly Arg Trp Ser Ala Leu Thr Pro Gly 
    370                 375                 380                 


Pro Pro Met Ala Thr Ala Gly Pro Ala Asp Ser Lys Phe Ser Asn Ser 
385                 390                 395                 400 


Gln Leu Ile Phe Ala Gly Pro Lys Gln Asn Gly Asn Thr Ala Thr Val 
                405                 410                 415     


Pro Gly Thr Leu Ile Phe Thr Ser Glu Glu Glu Leu Ala Ala Thr Asn 
            420                 425                 430         


Ala Thr Asp Thr Asp Met Trp Gly Asn Leu Pro Gly Gly Asp Gln Ser 
        435                 440                 445             


Asn Ser Asn Leu Pro Thr Val Asp Arg Leu Thr Ala Leu Gly Ala Val 
    450                 455                 460                 


Pro Gly Met Val Trp Gln Asn Arg Asp Ile Tyr Tyr Gln Gly Pro Ile 
465                 470                 475                 480 


Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser Pro Leu 
                485                 490                 495     


Ile Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Phe Ile Lys 
            500                 505                 510         


Asn Thr Pro Val Pro Ala Asn Pro Ala Thr Thr Phe Ser Ser Thr Pro 
        515                 520                 525             


Val Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Gln 
    530                 535                 540                 


Ile Asp Trp Glu Ile Gln Lys Glu Arg Ser Lys Arg Trp Asn Pro Glu 
545                 550                 555                 560 


Val Gln Phe Thr Ser Asn Tyr Gly Gln Gln Asn Ser Leu Leu Trp Ala 
                565                 570                 575     


Pro Asp Ala Ala Gly Lys Tyr Thr Glu Pro Arg Ala Ile Gly Thr Arg 
            580                 585                 590         


Tyr Leu Thr His His Leu 
        595             


<210> 5147
<211> 129
<212> DNA
<213> Adeno-associated virus 4

<400> 5147
ttggccactc cctctatgcg cgctcgctca ctcactcggc cctgcggcca gaggccggca       60

gtctggagac ctttggtgtc cagggcaggg ccgagtgagt gagcgagcgc gcatagaggg      120

agtggccaa                                                              129


<210> 5148
<211> 125
<212> DNA
<213> Adeno-associated virus 4

<400> 5148
ttggccactc cctctatgcg cgctcgctca ctcactcggc cctggagacc aaaggtctcc       60

agactgccgg cctctggccg gcagggccga gtgagtgagc gagcgcgcat agagggagtg      120

gccaa                                                                  125


<210> 5149
<211> 4768
<212> DNA
<213> Adeno-associated virus 4


<220>
<221> modified_base
<222> (3009)..(3009)
<223> a, c, t or g

<400> 5149
ttggccactc cctctatgcg cgctcgctca ctcactcggc cctggagacc aaaggtctcc       60

agactgccgg cctctggccg gcagggccga gtgagtgagc gagcgcgcat agagggagtg      120

gccaactcca tcatctaggt ttgcccactg acgtcaatgt gacgtcctag ggttagggag      180

gtccctgtat tagcagtcac gtgagtgtcg tatttcgcgg agcgtagcgg agcgcatacc      240

aagctgccac gtcacagcca cgtggtccgt ttgcgacagt ttgcgacacc atgtggtcag      300

gagggtatat aaccgcgagt gagccagcga ggagctccat tttgcccgcg aattttgaac      360

gagcagcagc catgccgggg ttctacgaga tcgtgctgaa ggtgcccagc gacctggacg      420

agcacctgcc cggcatttct gactcttttg tgagctgggt ggccgagaag gaatgggagc      480

tgccgccgga ttctgacatg gacttgaatc tgattgagca ggcacccctg accgtggccg      540

aaaagctgca acgcgagttc ctggtcgagt ggcgccgcgt gagtaaggcc ccggaggccc      600

tcttctttgt ccagttcgag aagggggaca gctacttcca cctgcacatc ctggtggaga      660

ccgtgggcgt caaatccatg gtggtgggcc gctacgtgag ccagattaaa gagaagctgg      720

tgacccgcat ctaccgcggg gtcgagccgc agcttccgaa ctggttcgcg gtgaccaaga      780

cgcgtaatgg cgccggaggc gggaacaagg tggtggacga ctgctacatc cccaactacc      840

tgctccccaa gacccagccc gagctccagt gggcgtggac taacatggac cagtatataa      900

gcgcctgttt gaatctcgcg gagcgtaaac ggctggtggc gcagcatctg acgcacgtgt      960

cgcagacgca ggagcagaac aaggaaaacc agaaccccaa ttctgacgcg ccggtcatca     1020

ggtcaaaaac ctccgccagg tacatggagc tggtcgggtg gctggtggac cgcgggatca     1080

cgtcagaaaa gcaatggatc caggaggacc aggcgtccta catctccttc aacgccgcct     1140

ccaactcgcg gtcacaaatc aaggccgcgc tggacaatgc ctccaaaatc atgagcctga     1200

caaagacggc tccggactac ctggtgggcc agaacccgcc ggaggacatt tccagcaacc     1260

gcatctaccg aatcctcgag atgaacgggt acgatccgca gtacgcggcc tccgtcttcc     1320

tgggctgggc gcaaaagaag ttcgggaaga ggaacaccat ctggctcttt gggccggcca     1380

cgacgggtaa aaccaacatc gcggaagcca tcgcccacgc cgtgcccttc tacggctgcg     1440

tgaactggac caatgagaac tttccgttca acgattgcgt cgacaagatg gtgatctggt     1500

gggaggaggg caagatgacg gccaaggtcg tagagagcgc caaggccatc ctgggcggaa     1560

gcaaggtgcg cgtggaccaa aagtgcaagt catcggccca gatcgaccca actcccgtga     1620

tcgtcacctc caacaccaac atgtgcgcgg tcatcgacgg aaactcgacc accttcgagc     1680

accaacaacc actccaggac cggatgttca agttcgagct caccaagcgc ctggagcacg     1740

actttggcaa ggtcaccaag caggaagtca aagacttttt ccggtgggcg tcagatcacg     1800

tgaccgaggt gactcacgag ttttacgtca gaaagggtgg agctagaaag aggcccgccc     1860

ccaatgacgc agatataagt gagcccaagc gggcctgtcc gtcagttgcg cagccatcga     1920

cgtcagacgc ggaagctccg gtggactacg cggacaggta ccaaaacaaa tgttctcgtc     1980

acgtgggtat gaatctgatg ctttttccct gccggcaatg cgagagaatg aatcagaatg     2040

tggacatttg cttcacgcac ggggtcatgg actgtgccga gtgcttcccc gtgtcagaat     2100

ctcaacccgt gtctgtcgtc agaaagcgga cgtatcagaa actgtgtccg attcatcaca     2160

tcatggggag ggcgcccgag gtggcctgct cggcctgcga actggccaat gtggacttgg     2220

atgactgtga catggaacaa taaatgactc aaaccagata tgactgacgg ttaccttcca     2280

gattggctag aggacaacct ctctgaaggc gttcgagagt ggtgggcgct gcaacctgga     2340

gcccctaaac ccaaggcaaa tcaacaacat caggacaacg ctcggggtct tgtgcttccg     2400

ggttacaaat acctcggacc cggcaacgga ctcgacaagg gggaacccgt caacgcagcg     2460

gacgcggcag ccctcgagca cgacaaggcc tacgaccagc agctcaaggc cggtgacaac     2520

ccctacctca agtacaacca cgccgacgcg gagttccagc agcggcttca gggcgacaca     2580

ccgtttgggg gcaacctcgg cagagcagtc ttccaggcca aaaagagggt tcttgaacct     2640

cttggtctgg ttgagcaagc gggtgagacg gctcctggaa agaagagacc gttgattgaa     2700

tccccccagc agcccgactc ctccacgggt atcggcaaaa aaggcaagca gccggctaaa     2760

aagaagctcg ttttcgaaga cgaaactgga gcaggcgacg gaccccctga gggatcaact     2820

tccggagcca tgtctgatga cagtgagatg cgtgcagcag ctggcggagc tgcagtcgag     2880

ggsggacaag gtgccgatgg agtgggtaat gcctcgggtg attggcattg cgattccacc     2940

tggtctgagg gccacgtcac gaccaccagc accagaacct gggtcttgcc cacctacaac     3000

aaccacctnt acaagcgact cggagagagc ctgcagtcca acacctacaa cggattctcc     3060

accccctggg gatactttga cttcaaccgc ttccactgcc acttctcacc acgtgactgg     3120

cagcgactca tcaacaacaa ctggggcatg cgacccaaag ccatgcgggt caaaatcttc     3180

aacatccagg tcaaggaggt cacgacgtcg aacggcgaga caacggtggc taataacctt     3240

accagcacgg ttcagatctt tgcggactcg tcgtacgaac tgccgtacgt gatggatgcg     3300

ggtcaagagg gcagcctgcc tccttttccc aacgacgtct ttatggtgcc ccagtacggc     3360

tactgtggac tggtgaccgg caacacttcg cagcaacaga ctgacagaaa tgccttctac     3420

tgcctggagt actttccttc gcagatgctg cggactggca acaactttga aattacgtac     3480

agttttgaga aggtgccttt ccactcgatg tacgcgcaca gccagagcct ggaccggctg     3540

atgaaccctc tcatcgacca gtacctgtgg ggactgcaat cgaccaccac cggaaccacc     3600

ctgaatgccg ggactgccac caccaacttt accaagctgc ggcctaccaa cttttccaac     3660

tttaaaaaga actggctgcc cgggccttca atcaagcagc agggcttctc aaagactgcc     3720

aatcaaaact acaagatccc tgccaccggg tcagacagtc tcatcaaata cgagacgcac     3780

agcactctgg acggaagatg gagtgccctg acccccggac ctccaatggc cacggctgga     3840

cctgcggaca gcaagttcag caacagccag ctcatctttg cggggcctaa acagaacggc     3900

aacacggcca ccgtacccgg gactctgatc ttcacctctg aggaggagct ggcagccacc     3960

aacgccaccg atacggacat gtggggcaac ctacctggcg gtgaccagag caacagcaac     4020

ctgccgaccg tggacagact gacagccttg ggagccgtgc ctggaatggt ctggcaaaac     4080

agagacattt actaccaggg tcccatttgg gccaagattc ctcataccga tggacacttt     4140

cacccctcac cgctgattgg tgggtttggg ctgaaacacc cgcctcctca aatttttatc     4200

aagaacaccc cggtacctgc gaatcctgca acgaccttca gctctactcc ggtaaactcc     4260

ttcattactc agtacagcac tggccaggtg tcggtgcaga ttgactggga gatccagaag     4320

gagcggtcca aacgctggaa ccccgaggtc cagtttacct ccaactacgg acagcaaaac     4380

tctctgttgt gggctcccga tgcggctggg aaatacactg agcctagggc tatcggtacc     4440

cgctacctca cccaccacct gtaataacct gttaatcaat aaaccggttt attcgtttca     4500

gttgaacttt ggtctccgtg tccttcttat cttatctcgt ttccatggct actgcgtaca     4560

taagcagcgg cctgcggcgc ttgcgcttcg cggtttacaa ctgccggtta atcagtaact     4620

tctggcaaac catgatgatg gagttggcca ctccctctat gcgcgctcgc tcactcactc     4680

ggccctggag accaaaggtc tccagactgc cggcctctgg ccggcagggc cgagtgagtg     4740

agcgagcgcg catagaggga gtggccaa                                        4768


<210> 5150
<211> 725
<212> PRT
<213> Adeno-associated virus 5

<400> 5150
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg 
    130                 135                 140                 


Ile Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp 
145                 150                 155                 160 


Ser Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser 
                165                 170                 175     


Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp 
            180                 185                 190         


Thr Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly 
        195                 200                 205             


Ala Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr 
    210                 215                 220                 


Trp Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu 
225                 230                 235                 240 


Pro Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val 
                245                 250                 255     


Asp Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly 
            260                 265                 270         


Tyr Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp 
        275                 280                 285             


Gln Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg 
    290                 295                 300                 


Val Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser 
305                 310                 315                 320 


Thr Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr 
                325                 330                 335     


Asp Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly 
            340                 345                 350         


Cys Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly 
        355                 360                 365             


Tyr Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser 
    370                 375                 380                 


Ser Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly 
385                 390                 395                 400 


Asn Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser 
                405                 410                 415     


Ser Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val 
            420                 425                 430         


Asp Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val 
        435                 440                 445             


Gln Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn 
    450                 455                 460                 


Trp Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser 
465                 470                 475                 480 


Gly Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met 
                485                 490                 495     


Glu Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met 
            500                 505                 510         


Thr Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met 
        515                 520                 525             


Ile Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu 
    530                 535                 540                 


Glu Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn 
545                 550                 555                 560 


Arg Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser 
                565                 570                 575     


Ser Thr Thr Ala Pro Thr Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val 
            580                 585                 590         


Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile 
        595                 600                 605             


Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala 
    610                 615                 620                 


Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys 
625                 630                 635                 640 


Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro Val 
                645                 650                 655     


Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met 
            660                 665                 670         


Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile 
        675                 680                 685             


Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro 
    690                 695                 700                 


Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr 
705                 710                 715                 720 


Leu Thr Arg Pro Leu 
                725 


<210> 5151
<211> 724
<212> PRT
<213> Adeno-associated virus 5

<400> 5151
Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 
    130                 135                 140                 


Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 
145                 150                 155                 160 


Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 
                165                 170                 175     


Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 
            180                 185                 190         


Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 
        195                 200                 205             


Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 
    210                 215                 220                 


Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 
225                 230                 235                 240 


Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 
                245                 250                 255     


Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 
305                 310                 315                 320 


Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 
                325                 330                 335     


Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 
            340                 345                 350         


Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 
    370                 375                 380                 


Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 
                405                 410                 415     


Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 
            420                 425                 430         


Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 
        435                 440                 445             


Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 
    450                 455                 460                 


Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 
465                 470                 475                 480 


Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 
                485                 490                 495     


Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 
            500                 505                 510         


Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 
        515                 520                 525             


Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 
    530                 535                 540                 


Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 
545                 550                 555                 560 


Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser Ser 
                565                 570                 575     


Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val Pro 
            580                 585                 590         


Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 
        595                 600                 605             


Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala Met 
    610                 615                 620                 


Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys Asn 
625                 630                 635                 640 


Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro Val Ser 
                645                 650                 655     


Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu 
            660                 665                 670         


Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln 
        675                 680                 685             


Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp 
    690                 695                 700                 


Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu 
705                 710                 715                 720 


Thr Arg Pro Leu 
                


<210> 5152
<211> 2175
<212> DNA
<213> Adeno-associated virus 5

<400> 5152
atgtcttttg ttgatcaccc tccagattgg ttggaagaag ttggtgaagg tcttcgcgag       60

tttttgggcc ttgaagcggg cccaccgaaa ccaaaaccca atcagcagca tcaagatcaa      120

gcccgtggtc ttgtgctgcc tggttataac tatctcggac ccggaaacgg tctcgatcga      180

ggagagcctg tcaacagggc agacgaggtc gcgcgagagc acgacatctc gtacaacgag      240

cagcttgagg cgggagacaa cccctacctc aagtacaacc acgcggacgc cgagtttcag      300

gagaagctcg ccgacgacac atccttcggg ggaaacctcg gaaaggcagt ctttcaggcc      360

aagaaaaggg ttctcgaacc ttttggcctg gttgaagagg gtgctaagac ggcccctacc      420

ggaaagcgga tagacgacca ctttccaaaa agaaagaagg ctcggaccga agaggactcc      480

aagccttcca cctcgtcaga cgccgaagct ggacccagcg gatcccagca gctgcaaatc      540

ccagcccaac cagcctcaag tttgggagct gatacaatgt ctgcgggagg tggcggccca      600

ttgggcgaca ataaccaagg tgccgatgga gtgggcaatg cctcgggaga ttggcattgc      660

gattccacgt ggatggggga cagagtcgtc accaagtcca cccgaacctg ggtgctgccc      720

agctacaaca accaccagta ccgagagatc aaaagcggct ccgtcgacgg aagcaacgcc      780

aacgcctact ttggatacag caccccctgg gggtactttg actttaaccg cttccacagc      840

cactggagcc cccgagactg gcaaagactc atcaacaact actggggctt cagaccccgg      900

tccctcagag tcaaaatctt caacattcaa gtcaaagagg tcacggtgca ggactccacc      960

accaccatcg ccaacaacct cacctccacc gtccaagtgt ttacggacga cgactaccag     1020

ctgccctacg tcgtcggcaa cgggaccgag ggatgcctgc cggccttccc tccgcaggtc     1080

tttacgctgc cgcagtacgg ttacgcgacg ctgaaccgcg acaacacaga aaatcccacc     1140

gagaggagca gcttcttctg cctagagtac tttcccagca agatgctgag aacgggcaac     1200

aactttgagt ttacctacaa ctttgaggag gtgcccttcc actccagctt cgctcccagt     1260

cagaacctgt tcaagctggc caacccgctg gtggaccagt acttgtaccg cttcgtgagc     1320

acaaataaca ctggcggagt ccagttcaac aagaacctgg ccgggagata cgccaacacc     1380

tacaaaaact ggttcccggg gcccatgggc cgaacccagg gctggaacct gggctccggg     1440

gtcaaccgcg ccagtgtcag cgccttcgcc acgaccaata ggatggagct cgagggcgcg     1500

agttaccagg tgcccccgca gccgaacggc atgaccaaca acctccaggg cagcaacacc     1560

tatgccctgg agaacactat gatcttcaac agccagccgg cgaacccggg caccaccgcc     1620

acgtacctcg agggcaacat gctcatcacc agcgagagcg agacgcagcc ggtgaaccgc     1680

gtggcgtaca acgtcggcgg gcagatggcc accaacaacc agagctccac cactgccccc     1740

gcgaccggca cgtacaacct ccaggaaatc gtgcccggca gcgtgtggat ggagagggac     1800

gtgtacctcc aaggacccat ctgggccaag atcccagaga cgggggcgca ctttcacccc     1860

tctccggcca tgggcggatt cggactcaaa cacccaccgc ccatgatgct catcaagaac     1920

acgcctgtgc ccggaaatat caccagcttc tcggacgtgc ccgtcagcag cttcatcacc     1980

cagtacagca ccgggcaggt caccgtggag atggagtggg agctcaagaa ggaaaactcc     2040

aagaggtgga acccagagat ccagtacaca aacaactaca acgaccccca gtttgtggac     2100

tttgccccgg acagcaccgg ggaatacaga accaccagac ctatcggaac ccgatacctt     2160

acccgacccc tttaa                                                      2175


<210> 5153
<211> 2208
<212> DNA
<213> Adeno-associated virus 6

<400> 5153
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggatgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaaga gggttctcga accttttggt ctggttgagg aaggtgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcattggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgaacatg ggccttgccc acctataaca accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc catttctcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaagctctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acgaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag ttgccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcagtacgg ctacctaacg     1140

ctcaacaatg gcagccaggc agtgggacgg tcatcctttt actgcctgga atatttccca     1200

tcgcagatgc tgagaacggg caataacttt accttcagct acaccttcga ggacgtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

cagtacctgt attacctgaa cagaactcag aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgggggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt accggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaac     1500

tttacctgga ctggtgcttc aaaatataac cttaatgggc gtgaatctat aatcaaccct     1560

ggcactgcta tggcctcaca caaagacgac aaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaggagag cgccggagct tcaaacactg cattggacaa tgtcatgatc     1680

acagacgaag aggaaatcaa agccactaac cccgtggcca ccgaaagatt tgggactgtg     1740

gcagtcaatc tccagagcag cagcacagac cctgcgaccg gagatgtgca tgttatggga     1800

gccttacctg gaatggtgtg gcaagacaga gacgtatacc tgcagggtcc tatttgggcc     1860

aaaattcctc acacggatgg acactttcac ccgtctcctc tcatgggcgg ctttggactt     1920

aagcacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggca     1980

gagttttcgg ctacaaagtt tgcttcattc atcacccagt attccacagg acaagtgagc     2040

gtggagattg aatgggagct gcagaaagaa aacagcaaac gctggaatcc cgaagtgcag     2100

tatacatcta actatgcaaa atctgccaac gttgatttca ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtcccctg                  2208


<210> 5154
<211> 736
<212> PRT
<213> Adeno-associated virus 6

<400> 5154
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5155
<211> 623
<212> PRT
<213> Adeno-associated virus 6

<400> 5155
Met Pro Gly Phe Tyr Glu Ile Val Ile Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Glu His Leu Pro Gly Ile Ser Asp Ser Phe Val Asn Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Asp Phe Leu 
    50                  55                  60                  


Val Gln Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Glu Ser Tyr Phe His Leu His Ile Leu Val Glu 
                85                  90                  95      


Thr Thr Gly Val Lys Ser Met Val Leu Gly Arg Phe Leu Ser Gln Ile 
            100                 105                 110         


Arg Asp Lys Leu Val Gln Thr Ile Tyr Arg Gly Ile Glu Pro Thr Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Glu Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Glu Glu Tyr Ile 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Ala Glu Arg Lys Arg Leu Val Ala His Asp 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Leu Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Arg Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys 
            260                 265                 270         


Ile Met Ala Leu Thr Lys Ser Ala Pro Asp Tyr Leu Val Gly Pro Ala 
        275                 280                 285             


Pro Pro Ala Asp Ile Lys Thr Asn Arg Ile Tyr Arg Ile Leu Glu Leu 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Ala Tyr Ala Gly Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Gln Lys Arg Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Ala Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
        435                 440                 445             


Glu Leu Thr Arg Arg Leu Glu His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Glu Phe Phe Arg Trp Ala Gln Asp His Val Thr Glu Val 
465                 470                 475                 480 


Ala His Glu Phe Tyr Val Arg Lys Gly Gly Ala Asn Lys Arg Pro Ala 
                485                 490                 495     


Pro Asp Asp Ala Asp Lys Ser Glu Pro Lys Arg Ala Cys Pro Ser Val 
            500                 505                 510         


Ala Asp Pro Ser Thr Ser Asp Ala Glu Gly Ala Pro Val Asp Phe Ala 
        515                 520                 525             


Asp Arg Tyr Gln Asn Lys Cys Ser Arg His Ala Gly Met Leu Gln Met 
    530                 535                 540                 


Leu Phe Pro Cys Lys Thr Cys Glu Arg Met Asn Gln Asn Phe Asn Ile 
545                 550                 555                 560 


Cys Phe Thr His Gly Thr Arg Asp Cys Ser Glu Cys Phe Pro Gly Val 
                565                 570                 575     


Ser Glu Ser Gln Pro Val Val Arg Lys Arg Thr Tyr Arg Lys Leu Cys 
            580                 585                 590         


Ala Ile His His Leu Leu Gly Arg Ala Pro Glu Ile Ala Cys Ser Ala 
        595                 600                 605             


Cys Asp Leu Val Asn Val Asp Leu Asp Asp Cys Val Ser Glu Gln 
    610                 615                 620             


<210> 5156
<211> 4683
<212> DNA
<213> Adeno-associated virus 6

<400> 5156
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtgaat tacgtcatag      180

ggttagggag gtcctgtatt agaggtcacg tgagtgtttt gcgacatttt gcgacaccat      240

gtggtcacgc tgggtattta agcccgagtg agcacgcagg gtctccattt tgaagcggga      300

ggtttgaacg cgcagcgcca tgccggggtt ttacgagatt gtgattaagg tccccagcga      360

ccttgacgag catctgcccg gcatttctga cagctttgtg aactgggtgg ccgagaagga      420

atgggagttg ccgccagatt ctgacatgga tctgaatctg attgagcagg cacccctgac      480

cgtggccgag aagctgcagc gcgacttcct ggtccagtgg cgccgcgtga gtaaggcccc      540

ggaggccctc ttctttgttc agttcgagaa gggcgagtcc tacttccacc tccatattct      600

ggtggagacc acgggggtca aatccatggt gctgggccgc ttcctgagtc agattaggga      660

caagctggtg cagaccatct accgcgggat cgagccgacc ctgcccaact ggttcgcggt      720

gaccaagacg cgtaatggcg ccggaggggg gaacaaggtg gtggacgagt gctacatccc      780

caactacctc ctgcccaaga ctcagcccga gctgcagtgg gcgtggacta acatggagga      840

gtatataagc gcgtgtttaa acctggccga gcgcaaacgg ctcgtggcgc acgacctgac      900

ccacgtcagc cagacccagg agcagaacaa ggagaatctg aaccccaatt ctgacgcgcc      960

tgtcatccgg tcaaaaacct ccgcacgcta catggagctg gtcgggtggc tggtggaccg     1020

gggcatcacc tccgagaagc agtggatcca ggaggaccag gcctcgtaca tctccttcaa     1080

cgccgcctcc aactcgcggt cccagatcaa ggccgctctg gacaatgccg gcaagatcat     1140

ggcgctgacc aaatccgcgc ccgactacct ggtaggcccc gctccgcccg ccgacattaa     1200

aaccaaccgc atttaccgca tcctggagct gaacggctac gaccctgcct acgccggctc     1260

cgtctttctc ggctgggccc agaaaaggtt cggaaaacgc aacaccatct ggctgtttgg     1320

gccggccacc acgggcaaga ccaacatcgc ggaagccatc gcccacgccg tgcccttcta     1380

cggctgcgtc aactggacca atgagaactt tcccttcaac gattgcgtcg acaagatggt     1440

gatctggtgg gaggagggca agatgacggc caaggtcgtg gagtccgcca aggccattct     1500

cggcggcagc aaggtgcgcg tggaccaaaa gtgcaagtcg tccgcccaga tcgatcccac     1560

ccccgtgatc gtcacctcca acaccaacat gtgcgccgtg attgacggga acagcaccac     1620

cttcgagcac cagcagccgt tgcaggaccg gatgttcaaa tttgaactca cccgccgtct     1680

ggagcatgac tttggcaagg tgacaaagca ggaagtcaaa gagttcttcc gctgggcgca     1740

ggatcacgtg accgaggtgg cgcatgagtt ctacgtcaga aagggtggag ccaacaagag     1800

acccgccccc gatgacgcgg ataaaagcga gcccaagcgg gcctgcccct cagtcgcgga     1860

tccatcgacg tcagacgcgg aaggagctcc ggtggacttt gccgacaggt accaaaacaa     1920

atgttctcgt cacgcgggca tgcttcagat gctgtttccc tgcaaaacat gcgagagaat     1980

gaatcagaat ttcaacattt gcttcacgca cgggaccaga gactgttcag aatgtttccc     2040

cggcgtgtca gaatctcaac cggtcgtcag aaagaggacg tatcggaaac tctgtgccat     2100

tcatcatctg ctggggcggg ctcccgagat tgcttgctcg gcctgcgatc tggtcaacgt     2160

ggatctggat gactgtgttt ctgagcaata aatgacttaa accaggtatg gctgccgatg     2220

gttatcttcc agattggctc gaggacaacc tctctgaggg cattcgcgag tggtgggact     2280

tgaaacctgg agccccgaaa cccaaagcca accagcaaaa gcaggacgac ggccggggtc     2340

tggtgcttcc tggctacaag tacctcggac ccttcaacgg actcgacaag ggggagcccg     2400

tcaacgcggc ggatgcagcg gccctcgagc acgacaaggc ctacgaccag cagctcaaag     2460

cgggtgacaa tccgtacctg cggtataacc acgccgacgc cgagtttcag gagcgtctgc     2520

aagaagatac gtcttttggg ggcaacctcg ggcgagcagt cttccaggcc aagaagaggg     2580

ttctcgaacc ttttggtctg gttgaggaag gtgctaagac ggctcctgga aagaaacgtc     2640

cggtagagca gtcgccacaa gagccagact cctcctcggg cattggcaag acaggccagc     2700

agcccgctaa aaagagactc aattttggtc agactggcga ctcagagtca gtccccgacc     2760

cacaacctct cggagaacct ccagcaaccc ccgctgctgt gggacctact acaatggctt     2820

caggcggtgg cgcaccaatg gcagacaata acgaaggcgc cgacggagtg ggtaatgcct     2880

caggaaattg gcattgcgat tccacatggc tgggcgacag agtcatcacc accagcaccc     2940

gaacatgggc cttgcccacc tataacaacc acctctacaa gcaaatctcc agtgcttcaa     3000

cgggggccag caacgacaac cactacttcg gctacagcac cccctggggg tattttgatt     3060

tcaacagatt ccactgccat ttctcaccac gtgactggca gcgactcatc aacaacaatt     3120

ggggattccg gcccaagaga ctcaacttca agctcttcaa catccaagtc aaggaggtca     3180

cgacgaatga tggcgtcacg accatcgcta ataaccttac cagcacggtt caagtcttct     3240

cggactcgga gtaccagttg ccgtacgtcc tcggctctgc gcaccagggc tgcctccctc     3300

cgttcccggc ggacgtgttc atgattccgc agtacggcta cctaacgctc aacaatggca     3360

gccaggcagt gggacggtca tccttttact gcctggaata tttcccatcg cagatgctga     3420

gaacgggcaa taactttacc ttcagctaca ccttcgagga cgtgcctttc cacagcagct     3480

acgcgcacag ccagagcctg gaccggctga tgaatcctct catcgaccag tacctgtatt     3540

acctgaacag aactcagaat cagtccggaa gtgcccaaaa caaggacttg ctgtttagcc     3600

gggggtctcc agctggcatg tctgttcagc ccaaaaactg gctacctgga ccctgttacc     3660

ggcagcagcg cgtttctaaa acaaaaacag acaacaacaa cagcaacttt acctggactg     3720

gtgcttcaaa atataacctt aatgggcgtg aatctataat caaccctggc actgctatgg     3780

cctcacacaa agacgacaaa gacaagttct ttcccatgag cggtgtcatg atttttggaa     3840

aggagagcgc cggagcttca aacactgcat tggacaatgt catgatcaca gacgaagagg     3900

aaatcaaagc cactaacccc gtggccaccg aaagatttgg gactgtggca gtcaatctcc     3960

agagcagcag cacagaccct gcgaccggag atgtgcatgt tatgggagcc ttacctggaa     4020

tggtgtggca agacagagac gtatacctgc agggtcctat ttgggccaaa attcctcaca     4080

cggatggaca ctttcacccg tctcctctca tgggcggctt tggacttaag cacccgcctc     4140

ctcagatcct catcaaaaac acgcctgttc ctgcgaatcc tccggcagag ttttcggcta     4200

caaagtttgc ttcattcatc acccagtatt ccacaggaca agtgagcgtg gagattgaat     4260

gggagctgca gaaagaaaac agcaaacgct ggaatcccga agtgcagtat acatctaact     4320

atgcaaaatc tgccaacgtt gatttcactg tggacaacaa tggactttat actgagcctc     4380

gccccattgg cacccgttac ctcacccgtc ccctgtaatt gtgtgttaat caataaaccg     4440

gttaattcgt gtcagttgaa ctttggtctc atgtcgttat tatcttatct ggtcaccata     4500

gcaaccggtt acacattaac tgcttagttg cgcttcgcga atacccctag tgatggagtt     4560

gcccactccc tctatgcgcg ctcgctcgct cggtggggcc ggcagagcag agctctgccg     4620

tctgcggacc tttggtccgc aggccccacc gagcgagcga gcgcgcatag agggagtggg     4680

caa                                                                   4683


<210> 5157
<211> 2211
<212> DNA
<213> Adeno-associated virus 6

<400> 5157
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggatgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaaga gggttctcga accttttggt ctggttgagg aaggtgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcattggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgaacatg ggccttgccc acctataaca accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc catttctcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaagctctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acgaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag ttgccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcagtacgg ctacctaacg     1140

ctcaacaatg gcagccaggc agtgggacgg tcatcctttt actgcctgga atatttccca     1200

tcgcagatgc tgagaacggg caataacttt accttcagct acaccttcga ggacgtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

cagtacctgt attacctgaa cagaactcag aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgggggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt accggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaac     1500

tttacctgga ctggtgcttc aaaatataac cttaatgggc gtgaatctat aatcaaccct     1560

ggcactgcta tggcctcaca caaagacgac aaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaggagag cgccggagct tcaaacactg cattggacaa tgtcatgatc     1680

acagacgaag aggaaatcaa agccactaac cccgtggcca ccgaaagatt tgggactgtg     1740

gcagtcaatc tccagagcag cagcacagac cctgcgaccg gagatgtgca tgttatggga     1800

gccttacctg gaatggtgtg gcaagacaga gacgtatacc tgcagggtcc tatttgggcc     1860

aaaattcctc acacggatgg acactttcac ccgtctcctc tcatgggcgg ctttggactt     1920

aagcacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggca     1980

gagttttcgg ctacaaagtt tgcttcattc atcacccagt attccacagg acaagtgagc     2040

gtggagattg aatgggagct gcagaaagaa aacagcaaac gctggaatcc cgaagtgcag     2100

tatacatcta actatgcaaa atctgccaac gttgatttca ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtcccctgta a              2211


<210> 5158
<211> 2214
<212> DNA
<213> Adeno-associated virus 7

<400> 5158
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

aacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtcattt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

gcaaagaaga gaccggtaga gccgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctctcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacag tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta atgcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

attaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccagtg aaactgcagg tagtaccaac gacaacacct acttcggcta cagcaccccc      840

tgggggtatt ttgactttaa cagattccac tgccacttct caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggccc aagaagctgc ggttcaagct cttcaacatc      960

caggtcaagg aggtcacgac gaatgacggc gttacgacca tcgctaataa ccttaccagc     1020

acgattcagg tattctcgga ctcggaatac cagctgccgt acgtcctcgg ctctgcgcac     1080

cagggctgcc tgcctccgtt cccggcggac gtcttcatga ttcctcagta cggctacctg     1140

actctcaaca atggcagtca gtctgtggga cgttcctcct tctactgcct ggagtacttc     1200

ccctctcaga tgctgagaac gggcaacaac tttgagttca gctacagctt cgaggacgtg     1260

cctttccaca gcagctacgc acacagccag agcctggacc ggctgatgaa tcccctcatc     1320

gaccagtact tgtactacct ggccagaaca cagagtaacc caggaggcac agctggcaat     1380

cgggaactgc agttttacca gggcgggcct tcaactatgg ccgaacaagc caagaattgg     1440

ttacctggac cttgcttccg gcaacaaaga gtctccaaaa cgctggatca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa tatcacctga acggcagaaa ctcgttggtt     1560

aatcccggcg tcgccatggc aactcacaag gacgacgagg accgcttttt cccatccagc     1620

ggagtcctga tttttggaaa aactggagca actaacaaaa ctacattgga aaatgtgtta     1680

atgacaaatg aagaagaaat tcgtcctact aatcctgtag ccacggaaga atacgggata     1740

gtcagcagca acttacaagc ggctaatact gcagcccaga cacaagttgt caacaaccag     1800

ggagccttac ctggcatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga tggcaacttt cacccgtctc ctttgatggg cggctttgga     1920

cttaaacatc cgcctcctca gatcctgatc aagaacactc ccgttcccgc taatcctccg     1980

gaggtgttta ctcctgccaa gtttgcttcg ttcatcacac agtacagcac cggacaagtc     2040

agcgtggaaa tcgagtggga gctgcagaag gaaaacagca agcgctggaa cccggagatt     2100

cagtacacct ccaactttga aaagcagact ggtgtggact ttgccgttga cagccagggt     2160

gtttactctg agcctcgccc tattggcact cgttacctca cccgtaatct gtaa           2214


<210> 5159
<211> 738
<212> PRT
<213> Adeno-associated virus 7

<400> 5159
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly 
    450                 455                 460                 


Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile 
    530                 535                 540                 


Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5160
<211> 737
<212> PRT
<213> Adeno-associated virus 7

<400> 5160
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asn Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Ala Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Val Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Glu Thr Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Arg Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Ser 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Pro Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Ser Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Thr Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Ile Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Glu Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5161
<211> 623
<212> PRT
<213> Adeno-associated virus 7

<400> 5161
Met Pro Gly Phe Tyr Glu Ile Val Ile Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Glu His Leu Pro Gly Ile Ser Asp Ser Phe Val Asn Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Asp Phe Leu 
    50                  55                  60                  


Val Gln Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Glu Ser Tyr Phe His Leu His Val Leu Val Glu 
                85                  90                  95      


Thr Thr Gly Val Lys Ser Met Val Leu Gly Arg Phe Leu Ser Gln Ile 
            100                 105                 110         


Arg Glu Lys Leu Val Gln Thr Ile Tyr Arg Gly Val Glu Pro Thr Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Glu Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Glu Glu Tyr Ile 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Ala Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Leu Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Arg Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys 
            260                 265                 270         


Ile Met Ala Leu Thr Lys Ser Ala Pro Asp Tyr Leu Val Gly Pro Ser 
        275                 280                 285             


Leu Pro Ala Asp Ile Lys Thr Asn Arg Ile Tyr Arg Ile Leu Glu Leu 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Ala Tyr Ala Gly Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Gln Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Ala Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
        435                 440                 445             


Glu Leu Thr Arg Arg Leu Glu His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Glu Phe Phe Arg Trp Ala Ser Asp His Val Thr Glu Val 
465                 470                 475                 480 


Ala His Glu Phe Tyr Val Arg Lys Gly Gly Ala Ser Lys Arg Pro Ala 
                485                 490                 495     


Pro Asp Asp Ala Asp Ile Ser Glu Pro Lys Arg Ala Cys Pro Ser Val 
            500                 505                 510         


Ala Asp Pro Ser Thr Ser Asp Ala Glu Gly Ala Pro Val Asp Phe Ala 
        515                 520                 525             


Asp Arg Tyr Gln Asn Lys Cys Ser Arg His Ala Gly Met Ile Gln Met 
    530                 535                 540                 


Leu Phe Pro Cys Lys Thr Cys Glu Arg Met Asn Gln Asn Phe Asn Ile 
545                 550                 555                 560 


Cys Phe Thr His Gly Val Arg Asp Cys Leu Glu Cys Phe Pro Gly Val 
                565                 570                 575     


Ser Glu Ser Gln Pro Val Val Arg Lys Lys Thr Tyr Arg Lys Leu Cys 
            580                 585                 590         


Ala Ile His His Leu Leu Gly Arg Ala Pro Glu Ile Ala Cys Ser Ala 
        595                 600                 605             


Cys Asp Leu Val Asn Val Asp Leu Asp Asp Cys Val Ser Glu Gln 
    610                 615                 620             


<210> 5162
<211> 4721
<212> DNA
<213> Adeno-associated virus 7

<400> 5162
ttggccactc cctctatgcg cgctcgctcg ctcggtgggg cctgcggacc aaaggtccgc       60

agacggcaga gctctgctct gccggcccca ccgagcgagc gagcgcgcat agagggagtg      120

gccaactcca tcactagggg taccgcgaag cgcctcccac gctgccgcgt cagcgctgac      180

gtaaatcacg tcatagggga gtggtcctgt attagctgtc acgtgagtgc ttttgcgaca      240

ttttgcgaca ccacgtggcc atttgaggta tatatggccg agtgagcgag caggatctcc      300

attttgaccg cgaaatttga acgagcagca gccatgccgg gtttctacga gatcgtgatc      360

aaggtgccga gcgacctgga cgagcacctg ccgggcattt ctgactcgtt tgtgaactgg      420

gtggccgaga aggaatggga gctgcccccg gattctgaca tggatctgaa tctgatcgag      480

caggcacccc tgaccgtggc cgagaagctg cagcgcgact tcctggtcca atggcgccgc      540

gtgagtaagg ccccggaggc cctgttcttt gttcagttcg agaagggcga gagctacttc      600

caccttcacg ttctggtgga gaccacgggg gtcaagtcca tggtgctagg ccgcttcctg      660

agtcagattc gggagaagct ggtccagacc atctaccgcg gggtcgagcc cacgctgccc      720

aactggttcg cggtgaccaa gacgcgtaat ggcgccggcg gggggaacaa ggtggtggac      780

gagtgctaca tccccaacta cctcctgccc aagacccagc ccgagctgca gtgggcgtgg      840

actaacatgg aggagtatat aagcgcgtgt ttgaacctgg ccgaacgcaa acggctcgtg      900

gcgcagcacc tgacccacgt cagccagacg caggagcaga acaaggagaa tctgaacccc      960

aattctgacg cgcccgtgat caggtcaaaa acctccgcgc gctacatgga gctggtcggg     1020

tggctggtgg accggggcat cacctccgag aagcagtgga tccaggagga ccaggcctcg     1080

tacatctcct tcaacgccgc ctccaactcg cggtcccaga tcaaggccgc gctggacaat     1140

gccggcaaga tcatggcgct gaccaaatcc gcgcccgact acctggtggg gccctcgctg     1200

cccgcggaca ttaaaaccaa ccgcatctac cgcatcctgg agctgaacgg gtacgatcct     1260

gcctacgccg gctccgtctt tctcggctgg gcccagaaaa agttcgggaa gcgcaacacc     1320

atctggctgt ttgggcccgc caccaccggc aagaccaaca ttgcggaagc catcgcccac     1380

gccgtgccct tctacggctg cgtcaactgg accaatgaga actttccctt caacgattgc     1440

gtcgacaaga tggtgatctg gtgggaggag ggcaagatga cggccaaggt cgtggagtcc     1500

gccaaggcca ttctcggcgg cagcaaggtg cgcgtggacc aaaagtgcaa gtcgtccgcc     1560

cagatcgacc ccacccccgt gatcgtcacc tccaacacca acatgtgcgc cgtgattgac     1620

gggaacagca ccaccttcga gcaccagcag ccgttgcagg accggatgtt caaatttgaa     1680

ctcacccgcc gtctggagca cgactttggc aaggtgacga agcaggaagt caaagagttc     1740

ttccgctggg ccagtgatca cgtgaccgag gtggcgcatg agttctacgt cagaaagggc     1800

ggagccagca aaagacccgc ccccgatgac gcggatataa gcgagcccaa gcgggcctgc     1860

ccctcagtcg cggatccatc gacgtcagac gcggaaggag ctccggtgga ctttgccgac     1920

aggtaccaaa acaaatgttc tcgtcacgcg ggcatgattc agatgctgtt tccctgcaaa     1980

acgtgcgaga gaatgaatca gaatttcaac atttgcttca cacacggggt cagagactgt     2040

ttagagtgtt tccccggcgt gtcagaatct caaccggtcg tcagaaaaaa gacgtatcgg     2100

aaactctgcg cgattcatca tctgctgggg cgggcgcccg agattgcttg ctcggcctgc     2160

gacctggtca acgtggacct ggacgactgc gtttctgagc aataaatgac ttaaaccagg     2220

tatggctgcc gatggttatc ttccagattg gctcgaggac aacctctctg agggcattcg     2280

cgagtggtgg gacctgaaac ctggagcccc gaaacccaaa gccaaccagc aaaagcagga     2340

caacggccgg ggtctggtgc ttcctggcta caagtacctc ggacccttca acggactcga     2400

caagggggag cccgtcaacg cggcggacgc agcggccctc gagcacgaca aggcctacga     2460

ccagcagctc aaagcgggtg acaatccgta cctgcggtat aaccacgccg acgccgagtt     2520

tcaggagcgt ctgcaagaag atacgtcatt tgggggcaac ctcgggcgag cagtcttcca     2580

ggccaagaag cgggttctcg aacctctcgg tctggttgag gaaggcgcta agacggctcc     2640

tgcaaagaag agaccggtag agccgtcacc tcagcgttcc cccgactcct ccacgggcat     2700

cggcaagaaa ggccagcagc ccgccagaaa gagactcaat ttcggtcaga ctggcgactc     2760

agagtcagtc cccgaccctc aacctctcgg agaacctcca gcagcgccct ctagtgtggg     2820

atctggtaca gtggctgcag gcggtggcgc accaatggca gacaataacg aaggtgccga     2880

cggagtgggt aatgcctcag gaaattggca ttgcgattcc acatggctgg gcgacagagt     2940

cattaccacc agcacccgaa cctgggccct gcccacctac aacaaccacc tctacaagca     3000

aatctccagt gaaactgcag gtagtaccaa cgacaacacc tacttcggct acagcacccc     3060

ctgggggtat tttgacttta acagattcca ctgccacttc tcaccacgtg actggcagcg     3120

actcatcaac aacaactggg gattccggcc caagaagctg cggttcaagc tcttcaacat     3180

ccaggtcaag gaggtcacga cgaatgacgg cgttacgacc atcgctaata accttaccag     3240

cacgattcag gtattctcgg actcggaata ccagctgccg tacgtcctcg gctctgcgca     3300

ccagggctgc ctgcctccgt tcccggcgga cgtcttcatg attcctcagt acggctacct     3360

gactctcaac aatggcagtc agtctgtggg acgttcctcc ttctactgcc tggagtactt     3420

cccctctcag atgctgagaa cgggcaacaa ctttgagttc agctacagct tcgaggacgt     3480

gcctttccac agcagctacg cacacagcca gagcctggac cggctgatga atcccctcat     3540

cgaccagtac ttgtactacc tggccagaac acagagtaac ccaggaggca cagctggcaa     3600

tcgggaactg cagttttacc agggcgggcc ttcaactatg gccgaacaag ccaagaattg     3660

gttacctgga ccttgcttcc ggcaacaaag agtctccaaa acgctggatc aaaacaacaa     3720

cagcaacttt gcttggactg gtgccaccaa atatcacctg aacggcagaa actcgttggt     3780

taatcccggc gtcgccatgg caactcacaa ggacgacgag gaccgctttt tcccatccag     3840

cggagtcctg atttttggaa aaactggagc aactaacaaa actacattgg aaaatgtgtt     3900

aatgacaaat gaagaagaaa ttcgtcctac taatcctgta gccacggaag aatacgggat     3960

agtcagcagc aacttacaag cggctaatac tgcagcccag acacaagttg tcaacaacca     4020

gggagcctta cctggcatgg tctggcagaa ccgggacgtg tacctgcagg gtcccatctg     4080

ggccaagatt cctcacacgg atggcaactt tcacccgtct cctttgatgg gcggctttgg     4140

acttaaacat ccgcctcctc agatcctgat caagaacact cccgttcccg ctaatcctcc     4200

ggaggtgttt actcctgcca agtttgcttc gttcatcaca cagtacagca ccggacaagt     4260

cagcgtggaa atcgagtggg agctgcagaa ggaaaacagc aagcgctgga acccggagat     4320

tcagtacacc tccaactttg aaaagcagac tggtgtggac tttgccgttg acagccaggg     4380

tgtttactct gagcctcgcc ctattggcac tcgttacctc acccgtaatc tgtaattgca     4440

tgttaatcaa taaaccggtt gattcgtttc agttgaactt tggtctcctg tgcttcttat     4500

cttatcggtt tccatagcaa ctggttacac attaactgct tgggtgcgct tcacgataag     4560

aacactgacg tcaccgcggt acccctagtg atggagttgg ccactccctc tatgcgcgct     4620

cgctcgctcg gtggggcctg cggaccaaag gtccgcagac ggcagagctc tgctctgccg     4680

gccccaccga gcgagcgagc gcgcatagag ggagtggcca a                         4721


<210> 5163
<211> 2214
<212> DNA
<213> Adeno-associated virus 7

<400> 5163
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

aacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtcattt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

gcaaagaaga gaccggtaga gccgtcacct cagcgttccc ccgactcctc cacgggcatc      480

ggcaagaaag gccagcagcc cgccagaaag agactcaatt tcggtcagac tggcgactca      540

gagtcagtcc ccgaccctca acctctcgga gaacctccag cagcgccctc tagtgtggga      600

tctggtacag tggctgcagg cggtggcgca ccaatggcag acaataacga aggtgccgac      660

ggagtgggta atgcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

attaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccagtg aaactgcagg tagtaccaac gacaacacct acttcggcta cagcaccccc      840

tgggggtatt ttgactttaa cagattccac tgccacttct caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggccc aagaagctgc ggttcaagct cttcaacatc      960

caggtcaagg aggtcacgac gaatgacggc gttacgacca tcgctaataa ccttaccagc     1020

acgattcagg tattctcgga ctcggaatac cagctgccgt acgtcctcgg ctctgcgcac     1080

cagggctgcc tgcctccgtt cccggcggac gtcttcatga ttcctcagta cggctacctg     1140

actctcaaca atggcagtca gtctgtggga cgttcctcct tctactgcct ggagtacttc     1200

ccctctcaga tgctgagaac gggcaacaac tttgagttca gctacagctt cgaggacgtg     1260

cctttccaca gcagctacgc acacagccag agcctggacc ggctgatgaa tcccctcatc     1320

gaccagtact tgtactacct ggccagaaca cagagtaacc caggaggcac agctggcaat     1380

cgggaactgc agttttacca gggcgggcct tcaactatgg ccgaacaagc caagaattgg     1440

ttacctggac cttgcttccg gcaacaaaga gtctccaaaa cgctggatca aaacaacaac     1500

agcaactttg cttggactgg tgccaccaaa tatcacctga acggcagaaa ctcgttggtt     1560

aatcccggcg tcgccatggc aactcacaag gacgacgagg accgcttttt cccatccagc     1620

ggagtcctga tttttggaaa aactggagca actaacaaaa ctacattgga aaatgtgtta     1680

atgacaaatg aagaagaaat tcgtcctact aatcctgtag ccacggaaga atacgggata     1740

gtcagcagca acttacaagc ggctaatact gcagcccaga cacaagttgt caacaaccag     1800

ggagccttac ctggcatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga tggcaacttt cacccgtctc ctttgatggg cggctttgga     1920

cttaaacatc cgcctcctca gatcctgatc aagaacactc ccgttcccgc taatcctccg     1980

gaggtgttta ctcctgccaa gtttgcttcg ttcatcacac agtacagcac cggacaagtc     2040

agcgtggaaa tcgagtggga gctgcagaag gaaaacagca agcgctggaa cccggagatt     2100

cagtacacct ccaactttga aaagcagact ggtgtggact ttgccgttga cagccagggt     2160

gtttactctg agcctcgccc tattggcact cgttacctca cccgtaatct gtaa           2214


<210> 5164
<211> 737
<212> PRT
<213> Adeno-associated virus 7

<400> 5164
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asn Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Ala Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Val Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Glu Thr Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Arg Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Ser 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Pro Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Ser Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Thr Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Ile Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Glu Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5165
<211> 2217
<212> DNA
<213> Adeno-associated virus 8

<400> 5165
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagaaag gccaacagcc cgccagaaaa agactcaatt ttggtcagac tggcgactca      540

gagtcagttc cagaccctca acctctcgga gaacctccag cagcgccctc tggtgtggga      600

cctaatacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacatcggg aggagccacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tttcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggag taccagctgc cgtacgttct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtgttca tgattcccca gtacggctac     1140

ctaacactca acaacggtag tcaggccgtg ggacgctcct ccttctactg cctggaatac     1200

tttccttcgc agatgctgag aaccggcaac aacttccagt ttacttacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcccacagc cagagcttgg accggctgat gaatcctctg     1320

attgaccagt acctgtacta cttgtctcgg actcaaacaa caggaggcac ggcaaatacg     1380

cagactctgg gcttcagcca aggtgggcct aatacaatgg ccaatcaggc aaagaactgg     1440

ctgccaggac cctgttaccg ccaacaacgc gtctcaacga caaccgggca aaacaacaat     1500

agcaactttg cctggactgc tgggaccaaa taccatctga atggaagaaa ttcattggct     1560

aatcctggca tcgctatggc aacacacaaa gacgacgagg agcgtttttt tcccagtaac     1620

gggatcctga tttttggcaa acaaaatgct gccagagaca atgcggatta cagcgatgtc     1680

atgctcacca gcgaggaaga aatcaaaacc actaaccctg tggctacaga ggaatacggt     1740

atcgtggcag ataacttgca gcagcaaaac acggctcctc aaattggaac tgtcaacagc     1800

cagggggcct tacccggtat ggtctggcag aaccgggacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccacccgt ctccgctgat gggcggcttt     1920

ggcctgaaac atcctccgcc tcagatcctg atcaagaaca cgcctgtacc tgcggatcct     1980

ccgaccacct tcaaccagtc aaagctgaac tctttcatca cgcaatacag caccggacag     2040

gtcagcgtgg aaattgaatg ggagctgcag aaggaaaaca gcaagcgctg gaaccccgag     2100

atccagtaca cctccaacta ctacaaatct acaagtgtgg actttgctgt taatacagaa     2160

ggcgtgtact ctgaaccccg ccccattggc acccgttacc tcacccgtaa tctgtaa        2217


<210> 5166
<211> 2213
<212> DNA
<213> Adeno-associated virus 8

<400> 5166
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagaaag gccaacagcc cgccagaaaa agactcaatt ttggtcagac tggcgactca      540

gagtcagttc cagaccctca acctctcgga gaacctccag cagcgccctc tggtgtggga      600

cctaatacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacatcggg aggagccacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tttcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggag taccagctgc cgtacgttct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtgttca tgattcccca gtacggctac     1140

ctaacactca acaacggtag tcaggccgtg ggacgctcct ccttctactg cctggaatac     1200

tttccttcgc agatgctgag aaccggcaac aacttccagt ttacttacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcccacagc cagagcttgg accggctgat gaatcctctg     1320

attgaccagt acctgtacta cttgtctcgg actcaaacaa caggaggcac ggcaaatacg     1380

cagactctgg gcttcagcca aggtgggcct aatacaatgg ccaatcaggc aaagaactgg     1440

ctgccaggac cctgttaccg ccaacaacgc gtctcaacga caaccgggca aaacaacaat     1500

agcaactttg cctggactgc tgggaccaaa taccatctga atggaagaaa ttcattggct     1560

aatcctggca tcgctatggc aacacacaaa gacgacgagg agcgtttttt tcccagtaac     1620

gggatcctga tttttggcaa acaaaatgct gccagagaca atgcggatta cagcgatgtc     1680

atgctcacca gcgaggaaga aatcaaaacc actaaccctg tggctacaga ggaatacggt     1740

atcgtggcag ataacttgca gcagcaaaac acggctcctc aaattggaac tgtcaacagc     1800

cagggggcct tacccggtat ggtctggcag aaccgggacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccacccgt ctccgctgat gggcggcttt     1920

ggcctgaaac atcctccgcc tcagatcctg atcaagaaca cgcctgtacc tgcggatcct     1980

ccgaccacct tcaaccagtc aaagctgaac tctttcatca cgcaatacag caccggacag     2040

gtcagcgtgg aaattgaatg ggagctgcag aaggaaaaca gcaagcgctg gaaccccgag     2100

atccagtaca cctccaacta ctacaaatct acaagtgtgg actttgctgt aatacagaag     2160

gcgtgtactc tgaaccccgc cccattggca cccgttacct cacccgtaat ctg            2213


<210> 5167
<211> 4393
<212> DNA
<213> Adeno-associated virus 8

<400> 5167
cagagaggga gtggccaact ccatcactag gggtagcgcg aagcgcctcc cacgctgccg       60

cgtcagcgct gacgtaaatt acgtcatagg ggagtggtcc tgtattagct gtcacgtgag      120

tgcttttgcg gcattttgcg acaccacgtg gccatttgag gtatatatgg ccgagtgagc      180

gagcaggatc tccattttga ccgcgaaatt tgaacgagca gcagccatgc cgggcttcta      240

cgagatcgtg atcaaggtgc cgagcgacct ggacgagcac ctgccgggca tttctgactc      300

gtttgtgaac tgggtggccg agaaggaatg ggagctgccc ccggattctg acatggatcg      360

gaatctgatc gagcaggcac ccctgaccgt ggccgagaag ctgcagcgcg acttcctggt      420

ccaatggcgc cgcgtgagta aggccccgga ggccctcttc tttgttcagt tcgagaaggg      480

cgagagctac tttcacctgc acgttctggt cgagaccacg ggggtcaagt ccatggtgct      540

aggccgcttc ctgagtcaga ttcgggaaaa gcttggtcca gaccatctac ccgcggggtc      600

gagccccacc ttgcccaact ggttcgcggt gaccaaagac gcggtaatgg cgccggcggg      660

ggggaacaag gtggtggacg agtgctacat ccccaactac ctcctgccca agactcagcc      720

cgagctgcag tgggcgtgga ctaacatgga ggagtatata agcgcgtgct tgaacctggc      780

cgagcgcaaa cggctcgtgg cgcagcacct gacccacgtc agccagacgc aggagcagaa      840

caaggagaat ctgaacccca attctgacgc gcccgtgatc aggtcaaaaa cctccgcgcg      900

ctatatggag ctggtcgggt ggctggtgga ccggggcatc acctccgaga agcagtggat      960

ccaggaggac caggcctcgt acatctcctt caacgccgcc tccaactcgc ggtcccagat     1020

caaggccgcg ctggacaatg ccggcaagat catggcgctg accaaatccg cgcccgacta     1080

cctggtgggg ccctcgctgc ccgcggacat tacccagaac cgcatctacc gcatcctcgc     1140

tctcaacggc tacgaccctg cctacgccgg ctccgtcttt ctcggctggg ctcagaaaaa     1200

gttcgggaaa cgcaacacca tctggctgtt tggacccgcc accaccggca agaccaacat     1260

tgcggaagcc atcgcccacg ccgtgccctt ctacggctgc gtcaactgga ccaatgagaa     1320

ctttcccttc aatgattgcg tcgacaagat ggtgatctgg tgggaggagg gcaagatgac     1380

ggccaaggtc gtggagtccg ccaaggccat tctcggcggc agcaaggtgc gcgtggacca     1440

aaagtgcaag tcgtccgccc agatcgaccc cacccccgtg atcgtcacct ccaacaccaa     1500

catgtgcgcc gtgattgacg ggaacagcac caccttcgag caccagcagc ctctccagga     1560

ccggatgttt aagttcgaac tcacccgccg tctggagcac gactttggca aggtgacaaa     1620

gcaggaagtc aaagagttct tccgctgggc cagtgatcac gtgaccgagg tggcgcatga     1680

gttttacgtc agaaagggcg gagccagcaa aagacccgcc cccgatgacg cggataaaag     1740

cgagcccaag cgggcctgcc cctcagtcgc ggatccatcg acgtcagacg cggaaggagc     1800

tccggtggac tttgccgaca ggtaccaaaa caaatgttct cgtcacgcgg gcatgcttca     1860

gatgctgttt ccctgcaaaa cgtgcgagag aatgaatcag aatttcaaca tttgcttcac     1920

acacggggtc agagactgct cagagtgttt ccccggcgtg tcagaatctc aaccggtcgt     1980

cagaaagagg acgtatcgga aactctgtgc gattcatcat ctgctggggc gggctcccga     2040

gattgcttgc tcggcctgcg atctggtcaa cgtggacctg gatgactgtg tttctgagca     2100

ataaatgact taaaccaggt atggctgccg atggttatct tccagattgg ctcgaggaca     2160

acctctctga gggcattcgc gagtggtggg cgctgaaacc tggagccccg aagcccaaag     2220

ccaaccagca aaagcaggac gacggccggg gtctggtgct tcctggctac aagtacctcg     2280

gacccttcaa cggactcgac aagggggagc ccgtcaacgc ggcggacgca gcggccctcg     2340

agcacgacaa ggcctacgac cagcagctgc aggcgggtga caatccgtac ctgcggtata     2400

accacgccga cgccgagttt caggagcgtc tgcaagaaga tacgtctttt gggggcaacc     2460

tcgggcgagc agtcttccag gccaagaagc gggttctcga acctctcggt ctggttgagg     2520

aaggcgctaa gacggctcct ggaaagaaga gaccggtaga gccatcaccc cagcgttctc     2580

cagactcctc tacgggcatc ggcaagaaag gccaacagcc cgccagaaaa agactcaatt     2640

ttggtcagac tggcgactca gagtcagttc cagaccctca acctctcgga gaacctccag     2700

cagcgccctc tggtgtggga cctaatacaa tggctgcagg cggtggcgca ccaatggcag     2760

acaataacga aggcgccgac ggagtgggta gttcctcggg aaattggcat tgcgattcca     2820

catggctggg cgacagagtc atcaccacca gcacccgaac ctgggccctg cccacctaca     2880

acaaccacct ctacaagcaa atctccaacg ggacatcggg aggagccacc aacgacaaca     2940

cctacttcgg ctacagcacc ccctgggggt attttgactt taacagattc cactgccact     3000

tttcaccacg tgactggcag cgactcatca acaacaactg gggattccgg cccaagagac     3060

tcagcttcaa gctcttcaac atccaggtca aggaggtcac gcagaatgaa ggcaccaaga     3120

ccatcgccaa taacctcacc agcaccatcc aggtgtttac ggactcggag taccagctgc     3180

cgtacgttct cggctctgcc caccagggct gcctgcctcc gttcccggcg gacgtgttca     3240

tgattcccca gtacggctac ctaacactca acaacggtag tcaggccgtg ggacgctcct     3300

ccttctactg cctggaatac tttccttcgc agatgctgag aaccggcaac aacttccagt     3360

ttacttacac cttcgaggac gtgcctttcc acagcagcta cgcccacagc cagagcttgg     3420

accggctgat gaatcctctg attgaccagt acctgtacta cttgtctcgg actcaaacaa     3480

caggaggcac ggcaaatacg cagactctgg gcttcagcca aggtgggcct aatacaatgg     3540

ccaatcaggc aaagaactgg ctgccaggac cctgttaccg ccaacaacgc gtctcaacga     3600

caaccgggca aaacaacaat agcaactttg cctggactgc tgggaccaaa taccatctga     3660

atggaagaaa ttcattggct aatcctggca tcgctatggc aacacacaaa gacgacgagg     3720

agcgtttttt tcccagtaac gggatcctga tttttggcaa acaaaatgct gccagagaca     3780

atgcggatta cagcgatgtc atgctcacca gcgaggaaga aatcaaaacc actaaccctg     3840

tggctacaga ggaatacggt atcgtggcag ataacttgca gcagcaaaac acggctcctc     3900

aaattggaac tgtcaacagc cagggggcct tacccggtat ggtctggcag aaccgggacg     3960

tgtacctgca gggtcccatc tgggccaaga ttcctcacac ggacggcaac ttccacccgt     4020

ctccgctgat gggcggcttt ggcctgaaac atcctccgcc tcagatcctg atcaagaaca     4080

cgcctgtacc tgcggatcct ccgaccacct tcaaccagtc aaagctgaac tctttcatca     4140

cgcaatacag caccggacag gtcagcgtgg aaattgaatg ggagctgcag aaggaaaaca     4200

gcaagcgctg gaaccccgag atccagtaca cctccaacta ctacaaatct acaagtgtgg     4260

actttgctgt taatacagaa ggcgtgtact ctgaaccccg ccccattggc acccgttacc     4320

tcacccgtaa tctgtaattg cctgttaatc aataaaccgg ttgattcgtt tcagttgaac     4380

tttggtctct gcg                                                        4393


<210> 5168
<211> 738
<212> PRT
<213> Adeno-associated virus 8

<400> 5168
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly 
    450                 455                 460                 


Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile 
    530                 535                 540                 


Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5169
<211> 737
<212> PRT
<213> Adeno-associated virus 8

<400> 5169
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly 
    450                 455                 460                 


Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile 
    530                 535                 540                 


Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Ile Gln Lys 
705                 710                 715                 720 


Ala Cys Thr Leu Asn Pro Ala Pro Leu Ala Pro Val Thr Ser Pro Val 
                725                 730                 735     


Ile 
    


<210> 5170
<211> 2217
<212> DNA
<213> Adeno-associated virus 8

<400> 5170
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagaaag gccaacagcc cgccagaaaa agactcaatt ttggtcagac tggcgactca      540

gagtcagttc cagaccctca acctctcgga gaacctccag cagcgccctc tggtgtggga      600

cctaatacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacatcggg aggagccacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tttcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggag taccagctgc cgtacgttct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtgttca tgattcccca gtacggctac     1140

ctaacactca acaacggtag tcaggccgtg ggacgctcct ccttctactg cctggaatac     1200

tttccttcgc agatgctgag aaccggcaac aacttccagt ttacttacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcccacagc cagagcttgg accggctgat gaatcctctg     1320

attgaccagt acctgtacta cttgtctcgg actcaaacaa caggaggcac ggcaaatacg     1380

cagactctgg gcttcagcca aggtgggcct aatacaatgg ccaatcaggc aaagaactgg     1440

ctgccaggac cctgttaccg ccaacaacgc gtctcaacga caaccgggca aaacaacaat     1500

agcaactttg cctggactgc tgggaccaaa taccatctga atggaagaaa ttcattggct     1560

aatcctggca tcgctatggc aacacacaaa gacgacgagg agcgtttttt tcccagtaac     1620

gggatcctga tttttggcaa acaaaatgct gccagagaca atgcggatta cagcgatgtc     1680

atgctcacca gcgaggaaga aatcaaaacc actaaccctg tggctacaga ggaatacggt     1740

atcgtggcag ataacttgca gcagcaaaac acggctcctc aaattggaac tgtcaacagc     1800

cagggggcct tacccggtat ggtctggcag aaccgggacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccacccgt ctccgctgat gggcggcttt     1920

ggcctgaaac atcctccgcc tcagatcctg atcaagaaca cgcctgtacc tgcggatcct     1980

ccgaccacct tcaaccagtc aaagctgaac tctttcatca cgcaatacag caccggacag     2040

gtcagcgtgg aaattgaatg ggagctgcag aaggaaaaca gcaagcgctg gaaccccgag     2100

atccagtaca cctccaacta ctacaaatct acaagtgtgg actttgctgt taatacagaa     2160

ggcgtgtact ctgaaccccg ccccattggc acccgttacc tcacccgtaa tctgtaa        2217


<210> 5171
<211> 4385
<212> DNA
<213> Adeno-associated virus 9

<400> 5171
cagagaggga gtggccaact ccatcactag gggtaatcgc gaagcgcctc ccacgctgcc       60

gcgtcagcgc tgacgtagat tacgtcatag gggagtggtc ctgtattagc tgtcacgtga      120

gtgcttttgc gacattttgc gacaccacat ggccatttga ggtatatatg gccgagtgag      180

cgagcaggat ctccattttg accgcgaaat ttgaacgagc agcagccatg ccgggcttct      240

acgagattgt gatcaaggtg ccgagcgacc tggacgagca cctgccgggc atttctgact      300

cttttgtgaa ctgggtggcc gagaaggaat gggagctgcc cccggattct gacatggatc      360

ggaatctgat cgagcaggca cccctgaccg tggccgagaa gctgcagcgc gacttcctgg      420

tccaatggcg ccgcgtgagt aaggccccgg aggccctctt ctttgttcag ttcgagaagg      480

gcgagagcta ctttcacctg cacgttctgg tcgagaccac gggggtcaag tccatggtgc      540

taggccgctt cctgagtcag attcgggaga agctggtcca gaccatctac cgcgggatcg      600

agccgaccct gcccaactgg ttcgcggtga ccaagacgcg taatggcgcc ggcgggggga      660

acaaggtggt ggacgagtgc tacatcccca actacctcct gcccaagact cagcccgagc      720

tgcagtgggc gtggactaac atggaggagt atataagcgc gtgcttgaac ctggccgagc      780

gcaaacggct cgtggcgcag cacctgaccc acgtcagcca gacgcaggag cagaacaagg      840

agaatctgaa ccccaattct gacgcgcccg tgatcaggtc aaaaacctcc gcgcgctaca      900

tggagctggt cgggtggctg gtggaccggg gcatcacctc cgagaagcag tggatccagg      960

aggaccaggc ctcgtacatc tccttcaacg ccgcctccaa ctcgcggtcc cagatcaagg     1020

ccgcgctgga caatgccggc aagatcatgg cgctgaccaa atccgcgccc gactacctgg     1080

taggcccttc acttccggtg gacattacgc agaaccgcat ctaccgcatc ctgcagctca     1140

acggctacga ccctgcctac gccggctccg tctttctcgg ctgggcacaa aagaagttcg     1200

ggaaacgcaa caccatctgg ctgtttgggc cggccaccac gggaaagacc aacatcgcag     1260

aagccattgc ccacgccgtg cccttctacg gctgcgtcaa ctggaccaat gagaactttc     1320

ccttcaacga ttgcgtcgac aagatggtga tctggtggga ggagggcaag atgacggcca     1380

aggtcgtgga gtccgccaag gccattctcg gcggcagcaa ggtgcgcgtg gaccaaaagt     1440

gcaagtcgtc cgcccagatc gaccccactc ccgtgatcgt cacctccaac accaacatgt     1500

gcgccgtgat tgacgggaac agcaccacct tcgagcacca gcagcctctc caggaccgga     1560

tgtttaagtt cgaactcacc cgccgtctgg agcacgactt tggcaaggtg acaaagcagg     1620

aagtcaaaga gttcttccgc tgggccagtg atcacgtgac cgaggtggcg catgagtttt     1680

acgtcagaaa gggcggagcc agcaaaagac ccgcccccga tgacgcggat aaaagcgagc     1740

ccaagcgggc ctgcccctca gtcgcggatc catcgacgtc agacgcggaa ggagctccgg     1800

tggactttgc cgacaggtac caaaacaaat gttctcgtca cgcgggcatg cttcagatgc     1860

tgcttccctg caaaacgtgc gagagaatga atcagaattt caacatttgc ttcacacacg     1920

gggtcagaga ctgctcagag tgtttccccg gcgtgtcaga atctcaaccg gtcgtcagaa     1980

agaggacgta tcggaaactc tgtgcgattc atcatctgct ggggcgggct cccgagattg     2040

cttgctcggc ctgcgatctg gtcaacgtgg acctggatga ctgtgtttct gagcaataaa     2100

tgacttaaac caggtatggc tgccgatggt tatcttccag attggctcga ggacaacctc     2160

tctgagggca ttcgcgagtg gtgggcgctg aaacctggag ccccgaagcc caaagccaac     2220

cagcaaaagc aggacgacgg ccggggtctg gtgcttcctg gctacaagta cctcggaccc     2280

ttcaacggac tcgacaaggg ggagcccgtc aacgcggcgg acgcagcggc cctcgagcac     2340

ggcaaggcct acgaccagca gctgcaggcg ggtgacaatc cgtacctgcg gtataaccac     2400

gccgacgccg agtttcagga gcgtctgcaa gaagatacgt cttttggggg caacctcggg     2460

cgagcagtct tccaggccaa gaagcgggtt ctcgaacctc tcggtctggt tgaggaaggc     2520

gctaagacgg ctcctggaaa gaagagaccg gtagagccat caccccagcg ttctccagac     2580

tcctctacgg gcatcggcaa gaaaggccaa cagcccgcca gaaaaagact caattttggt     2640

cagactggcg actcagagtc agttccagac cctcaacctc tcggagaacc tccagcagcg     2700

ccctctggtg tgggacctaa tacaatggct gcaggcggtg gcgcaccaat ggcagacaat     2760

aacgaaggcg ccgacggagt gggtaattcc tcgggaaatt ggcattgcga ttccacatgg     2820

ctgggggaca gagtcatcac caccagcacc cgaacctggg cattgcccac ctacaacaac     2880

cacctctaca agcaaatctc caatggaaca tcgggaggaa gcaccaacga caacacctac     2940

tttggctaca gcaccccctg ggggtatttt gacttcaaca gattccactg ccacttctca     3000

ccacgtgact ggcagcgact catcaacaac aactggggat tccggccaaa gagactcaac     3060

ttcaagctgt tcaacatcca ggtcaaggag gttacgacga acgaaggcac caagaccatc     3120

gccaataacc ttaccagcac cgtccaggtc tttacggact cggagtacca gctaccgtac     3180

gtcctaggct ctgcccacca aggatgcctg ccaccgtttc ctgcagacgt cttcatggtt     3240

cctcagtacg gctacctgac gctcaacaat ggaagtcaag cgttaggacg ttcttctttc     3300

tactgtctgg aatacttccc ttctcagatg ctgagaaccg gcaacaactt tcagttcagc     3360

tacactttcg aggacgtgcc tttccacagc agctacgcac acagccagag tctagatcga     3420

ctgatgaacc ccctcatcga ccagtaccta tactacctgg tcagaacaca gacaactgga     3480

actgggggaa ctcaaacttt ggcattcagc caagcaggcc ctagctcaat ggccaatcag     3540

gctagaaact gggtacccgg gccttgctac cgtcagcagc gcgtctccac aaccaccaac     3600

caaaataaca acagcaactt tgcgtggacg ggagctgcta aattcaagct gaacgggaga     3660

gactcgctaa tgaatcctgg cgtggctatg gcatcgcaca aagacgacga ggaccgcttc     3720

tttccatcaa gtggcgttct catatttggc aagcaaggag ccgggaacga tggagtcgac     3780

tacagccagg tgctgattac agatgaggaa gaaattaaag ccaccaaccc tgtagccaca     3840

gaggaatacg gagcagtggc catcaacaac caggccgcta acacgcaggc gcaaactgga     3900

cttgtgcata accagggagt tattcctggt atggtctggc agaaccggga cgtgtacctg     3960

cagggcccta tttgggctaa aatacctcac acagatggca actttcaccc gtctcctctg     4020

atgggtggat ttggactgaa acacccacct ccacagattc taattaaaaa tacaccagtg     4080

ccggcagatc ctcctcttac cttcaatcaa gccaagctga actctttcat cacgcagtac     4140

agcacgggac aagtcagcgt ggaaatcgag tgggagctgc agaaagaaaa cagcaagcgc     4200

tggaatccag agatccagta tacttcaaac tactacaaat ctacaaatgt ggactttgct     4260

gtcaatacca aaggtgttta ctctgagcct cgccccattg gtactcgtta cctcacccgt     4320

aatttgtaat tgcctgttaa tcaataaacc ggttaattcg tttcagttga actttggtct     4380

ctgcg                                                                 4385


<210> 5172
<211> 4382
<212> DNA
<213> Adeno-associated virus 9

<400> 5172
cagagaggga gtggccaact ccatcactag gggtaatcgc gaagcgcctc ccacgctgcc       60

gcgtcagcgc tgacgtagat tacgtcatag gggagtggtc ctgtattagc tgtcacgtga      120

gtgcttttgc gacattttgc gacaccacat ggccatttga ggtatatatg gccgagtgag      180

cgagcaggat ctccattttg accgcgaaat ttgaacgagc agcagccatg ccgggcttct      240

acgagattgt gatcaaggtg ccgagcgacc tggacgagca cctgccgggc atttctgact      300

cttttgtgaa ctgggtggcc gagaaggaat gggagctgcc cccggattct gacatggatc      360

ggaatctgat cgagcaggca cccctgaccg tggccgagaa gctgtagcgc gacttcctgg      420

tccaatggcg ccgcgtgagt aaggccccgg aggccctctt ctttgttcag ttcgagaagg      480

gcgagagcta ctttcacctg cacgttctgg tcgagaccac gggggtcaag tccatggtgc      540

taggccgctt cctgagtcag attcgggaga agctggtcca gaccatctac cgcgggatcg      600

agccgaccct gcccaactgg ttcgcggtga ccaagacgcg taatggcgcc ggcgggggga      660

acaaggtggt ggacgagtgc tacatcccca actacctcct gcccaagact cagcccgagc      720

tgcagtgggc gtggactaac atggaggagt atataagcgc gtgcttgaac ctggccgagc      780

gcaaacggct cgtggcgcag cacctgaccc acgtcagcca gacgcaggag cagaacaagg      840

agaatctgaa ccccaattct gacgcgcccg tgatcaggtc aaaaacctcc gcgcgctaca      900

tggagctggt cgggtggctg gtggaccggg gcatcacctc cgagaagcag tggatccagg      960

aggaccaggc ctcgtacatc tccttcaacg ccgcctccaa ctcgcggtcc cagatcaagg     1020

ccgcgctgga caatgccggc aagatcatgg cgctgaccaa atccgcgccc gactacctgg     1080

taggcccttc acttccggtg gacattacgc agaaccgcat ctaccgcatc ctgcagctca     1140

acggctacga ccctgcctac gccggctccg tctttctcgg ctgggcacaa aagaagttcg     1200

ggaaacgcaa caccatctgg ctgtttgggc cggccaccac gggaaagacc aacatcgcag     1260

aagccattgc ccacgccgtg cccttctacg gctgcgtcaa ctggaccaat gagaactttc     1320

ccttcaacga ttgcgtcgac aagatggtga tctggtggga ggagggcaag atgacggcca     1380

aggtcgtgga gtccgccaag gccattctcg gcggcagcaa ggtgcgcgtg gaccaaaagt     1440

gcaagtcgtc cgcccagatc gaccccactc ccgtgatcgt cacctccaac accaacatgt     1500

gcgccgtgat tgacgggaac agcaccacct tcgagcacca gcagcctctc caggaccgga     1560

tgtttaagtt cgaactcacc cgccgtctgg agcacgactt tggcaaggtg acaaagcagg     1620

aagtcaaaga gttcttccgc tgggccagtg atcacgtgac cgaggtggcg catgagtttt     1680

acgtcagaaa gggcggagcc agcaaaagac ccgcccccga tgacgcggat aaaagcgagc     1740

ccaagcgggc ctgcccctca gtcgcggatc catcgacgtc agacgcggaa ggagctccgg     1800

tggactttgc cgacaggtac caaaacaaat gttctcgtca cgcgggcatg cttcagatgc     1860

tgcttccctg caaaacgtgc gagagaatga atcagaattt caacatttgc ttcacacacg     1920

gggtcagaga ctgctcagag tgtttccccg gcgtgtcaga atctcaaccg gtcgtcagaa     1980

agaggacgta tcggaaactc tgtgcgattc atcatctgct ggggcgggct cccgagattg     2040

cttgctcggc ctgcgatctg gtcaacgtgg acctggatga ctgtgtttct gagcaataaa     2100

tgacttaaac caggtatggc tgccgatggt tatcttccag attggctcga ggacaacctc     2160

tctgagggca ttcgcgagtg gtgggacctg aaacctggag ccccgaaacc caaagccaac     2220

cagcaaaagc aggacgacgg ccggggtctg gtgcttcctg gctacaagta cctcggaccc     2280

ttcaacggac tcgacaaggg ggagcccgtc aacgcggcgg acgcagcggc cctcgagcac     2340

gacaaggcct acgaccagca gctcaaagcg ggtgacaatc cgtacctgcg gtataaccac     2400

gccgacgccg agtttcagga gcgtctgcaa gaagatacgt cttttggggg caacctcggg     2460

cgagcagtct tccaggccaa gaagcgggtt ctcgaacctc tcggtctggt tgaggaaggc     2520

gctaagacgg ctcctggaaa gaagagaccg gtagagcagt caccccaaga accagactca     2580

tcctcgggca tcggcaaatc aggccagcag cccgctaaaa agagactcaa ttttggtcag     2640

actggcgact cagagtcagt ccccgaccca caacctctcg gagaacctcc agaagccccc     2700

tcaggtctgg gacctaatac aatggcttca ggcggtggcg ctccaatggc agacaataac     2760

gaaggcgccg acggagtggg taattcctcg ggaaattggc attgcgattc cacatggctg     2820

ggggacagag tcatcaccac cagcacccga acctgggcat tgcccaccta caacaaccac     2880

ctctacaagc aaatctccaa tggaacatcg ggaggaagca ccaacgacaa cacctacttt     2940

ggctacagca ccccctgggg gtattttgac ttcaacagat tccactgcca cttctcacca     3000

cgtgactggc agcgactcat caacaacaac tggggattcc ggccaaagag actcaacttc     3060

aagctgttca acatccaggt caaggaggtt acgacgaacg aaggcaccaa gaccatcgcc     3120

aataacctta ccagcaccgt ccaggtcttt acggactcgg agtaccagct accgtacgtc     3180

ctaggctctg cccaccaagg atgcctgcca ccgtttcctg cagacgtctt catggttcct     3240

cagtacggct acctgacgct caacaatgga agtcaagcgt taggacgttc ttctttctac     3300

tgtctggaat acttcccttc tcagatgctg agaaccggca acaactttca gttcagctac     3360

actttcgagg acgtgccttt ccacagcagc tacgcacaca gccagagtct agatcgactg     3420

atgaaccccc tcatcgacca gtacctatac tacctggtca gaacacagac aactggaact     3480

gggggaactc aaactttggc attcagccaa gcaggcccta gctcaatggc caatcaggct     3540

agaaactggg tacccgggcc ttgctaccgt cagcagcgcg tctccacaac caccaaccaa     3600

aataacaaca gcaactttgc gtggacggga gctgctaaat tcaagctgaa cgggagagac     3660

tcgctaatga atcctggcgt ggctatggca tcgcacaaag acgacgagga ccgcttcttt     3720

ccatcaagtg gcgttctcat atttggcaag caaggagccg ggaacgatgg agtcgactac     3780

agccaggtgc tgattacaga tgaggaagaa attaaagcca ccaaccctgt agccacagag     3840

gaatacggag cagtggccat caacaaccag gccgctaaca cgcaggcgca aactggactt     3900

gtgcataacc agggagttat tcctggtatg gtctggcaga accgggacgt gtacctgcag     3960

ggccctattt gggctaaaat acctcacaca gatggcaact ttcacccgtc tcctctgatg     4020

ggtggatttg gactgaaaca cccacctcca cagattctaa ttaaaaatac accagtgccg     4080

gcagatcctc ctcttacctt caatcaagcc aagctgaact ctttcatcac gcagtacagc     4140

acgggacaag tcagcgtgga aatcgagtgg gagctgcaga aagaaaacag caagcgctgg     4200

aatccagaga tccagtatac ttcaaactac tacaaatcta caaatgtgga ctttgctgtc     4260

aataccgaag gtgtttactc tgagcctcgc cccattggta ctcgttacct cacccgtaat     4320

ttgtaattgc ctgttaatca ataaaccggt taattcgttt cagttgaact ttggtctctg     4380

cg                                                                    4382


<210> 5173
<211> 736
<212> PRT
<213> Adeno-associated virus 9

<400> 5173
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 5174
<211> 736
<212> PRT
<213> Adeno-associated virus 9

<400> 5174
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Glu Ala Pro Ser Gly Leu Gly Pro Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Leu Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Val 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Thr Gly Gly Thr Gln Thr Leu Ala Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Ser Ser Met Ala Asn Gln Ala Arg Asn Trp Val Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Asn Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Ala Lys Phe Lys Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Met Asn Pro Gly Val Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Ala Gly Asn Asp Gly Val Asp Tyr Ser Gln Val Leu Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ala Val Ala Ile Asn Asn Gln Ala Ala Asn Thr Gln Ala Gln 
            580                 585                 590         


Thr Gly Leu Val His Asn Gln Gly Val Ile Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Leu Thr Phe Asn Gln Ala Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 5175
<211> 623
<212> PRT
<213> Adeno-associated virus 9

<400> 5175
Met Pro Gly Phe Tyr Glu Ile Val Ile Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Glu His Leu Pro Gly Ile Ser Asp Ser Phe Val Asn Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Arg Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Asp Phe Leu 
    50                  55                  60                  


Val Gln Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Glu Ser Tyr Phe His Leu His Val Leu Val Glu 
                85                  90                  95      


Thr Thr Gly Val Lys Ser Met Val Leu Gly Arg Phe Leu Ser Gln Ile 
            100                 105                 110         


Arg Glu Lys Leu Val Gln Thr Ile Tyr Arg Gly Ile Glu Pro Thr Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Glu Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Glu Glu Tyr Ile 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Ala Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Leu Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Arg Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys 
            260                 265                 270         


Ile Met Ala Leu Thr Lys Ser Ala Pro Asp Tyr Leu Val Gly Pro Ser 
        275                 280                 285             


Leu Pro Val Asp Ile Thr Gln Asn Arg Ile Tyr Arg Ile Leu Gln Leu 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Ala Tyr Ala Gly Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Gln Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Ala Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
        435                 440                 445             


Glu Leu Thr Arg Arg Leu Glu His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Glu Phe Phe Arg Trp Ala Ser Asp His Val Thr Glu Val 
465                 470                 475                 480 


Ala His Glu Phe Tyr Val Arg Lys Gly Gly Ala Ser Lys Arg Pro Ala 
                485                 490                 495     


Pro Asp Asp Ala Asp Lys Ser Glu Pro Lys Arg Ala Cys Pro Ser Val 
            500                 505                 510         


Ala Asp Pro Ser Thr Ser Asp Ala Glu Gly Ala Pro Val Asp Phe Ala 
        515                 520                 525             


Asp Arg Tyr Gln Asn Lys Cys Ser Arg His Ala Gly Met Leu Gln Met 
    530                 535                 540                 


Leu Leu Pro Cys Lys Thr Cys Glu Arg Met Asn Gln Asn Phe Asn Ile 
545                 550                 555                 560 


Cys Phe Thr His Gly Val Arg Asp Cys Ser Glu Cys Phe Pro Gly Val 
                565                 570                 575     


Ser Glu Ser Gln Pro Val Val Arg Lys Arg Thr Tyr Arg Lys Leu Cys 
            580                 585                 590         


Ala Ile His His Leu Leu Gly Arg Ala Pro Glu Ile Ala Cys Ser Ala 
        595                 600                 605             


Cys Asp Leu Val Asn Val Asp Leu Asp Asp Cys Val Ser Glu Gln 
    610                 615                 620             


<210> 5176
<211> 1797
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5176
acggctccga ccggagacaa gcggaaaggc gaagacgaac ctcgtttgcc cgacacttct       60

tcacagactc ccaagaaaaa caagaagcct cgcaaggaaa gaccttccgg cggggcagaa      120

gatccgggcg aaggcacctc ttccaacgct ggagcagcag cacccgcctc tagtgtggga      180

tcatctatca tggctgaagg aggtggcggc ccagtgggcg atgcaggcca gggtgccgat      240

ggagtgggca attcctccgg aaattggcat tgcgattccc aatggctgga aaacggagtc      300

gtcactcgaa ccacccgaac ctgggtcttg cccagctaca acaaccacct gtacaaacga      360

atccaaggac ccagcggagg cgacaacaac aacaaattct ttggattcag caccccctgg      420

ggatactttg actacaatcg attccactgc cacttttccc cgcgagactg gcaacgactc      480

atcaacaaca actggggcat ccgtcccaaa gcgatgcgct ttagactctt taacatccag      540

gttaaagagg tcacggtcca agacttcaac accaccatcg gcaacaacct caccagtacg      600

gtccaggtct ttgcggacaa ggactaccaa ctgccgtacg tcctcggatc ggctaccgaa      660

ggcaccttcc cgccgttccc agcggatatc tacacgatcc cgcagtacgg gtactgcacg      720

ctaaactaca acaacgaggc ggtggatcgt tcggccttct actgtctgga ctactttccc      780

tcagacatgc tgcggacagg aaataacttt gagtttactt acaccttcga ggacgttcct      840

ttccatagca tgtttgccca caaccagacg ctagaccggc tgatgaatcc cctcgtggat      900

cagtacctct gggctttcag ctccgtcagc caagcaggct catctggacg agctcttcat      960

tactcgcggg cgactaaaac caacatggcg gctcaatata ggaactggtt acctgggcct     1020

ttcttccgtg atcagcaaat ctttacgggc gctagcaaca tcactaaaaa taacgtcttt     1080

agcgtttggg aaaaaggcaa gcaatgggaa ctcgacaatc ggaccaacct aatgcagccc     1140

ggtcctgcgg cagcgaccac ctttagcgga gaacctgacc gtcaagccat gcaaaacacg     1200

ctggctttta gcaggaccgt ctacgatcaa acgaccgcca cgaccgatcg taaccagata     1260

ctcatcacca acgaagacga aatcagaccc accaactcgg tcggtatcga cgcgtgggga     1320

gcagttccca ccaacaacca gtcgatcgtg acccccggca ctcgcgcggc cgtcaacaat     1380

caaggggcgc ttcccgggat ggtgtggcaa aacagagaca tttaccctac agggacccat     1440

ttggccaaaa ttcccgacac tgacaatcac ttccatccgt ccccgcttat tgggcggttt     1500

ggctgcaagc atccccctcc ccagattttc attaaaaaca cacccgtccc tgccaaccct     1560

tcggaaacgt tccagacggc caaagtggcc tccttcatca accagtactc gaccggacag     1620

tgcaccgtcg aaatcttttg ggaactcaag aaggaaacct ccaagcgctg gaaccccgaa     1680

atccagttca cctccaactt tggcaacgcg gccgacatcc agtttgccgt ctccgacacg     1740

ggatcctatt ccgaacctcg tcccatcggt acccgttacc ttaccaaacc tctgtaa        1797


<210> 5177
<211> 1989
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5177
atgaggtcgt actacgaggt catcgttcag ctgcccaacg acgtcgagag tcaggtacct       60

ggaatctccg attcgttcgt caactggatt acgtcgcgag aatggacgtt gcctgaggac      120

gccgattggg atttggacca ggtcgatcaa gttcaactga cgctcggcga caaaatccaa      180

cgggagattc gaactcattg ggggacgatg gccaaagaac cggactttca ctattttatc      240

caactggaac aaggtgaggt gttctttcat ttacacgtcc tgctggaaac gtgttccgta      300

aagccgatgg tactcggaag atatatccga catattcaac aaaaaattgt gagtaaagtc      360

tactgcgcca cgagcctacg atggaaggat ggatgcgtgg tgaccaagac caaaaatttc      420

gggggcgcga acaaggtccg ggccgagtcg tatattcccg cctacctgat cccgaaacag      480

caaccggaag tgcagtgggc gtggactaac gtgcccgagt atataaaagc gtgcttgcac      540

cgagaactgc gtgccagtct cgcgcgactt cacttcgagg aggcgggcgt ctcgcaatcc      600

aaggaaaatc tcgcgagaac tgcagacggc gctcccgtga tgccgacccg cgtcagcaaa      660

cgctacatgg agctcgtgga ttggctcgtg gagaagggga tcaccaccga gaaggaatgg      720

ctgctggaaa acagagaaag ctttcggagc tttcaggcct cgagcaactc ggcgcgtcag      780

atcaagacgg ccctgcaagg cgccattcag gagatgcttc tgaccaagac ggcggaggac      840

tacctcgtcg gaaaggatcc cgtctcggac gacgacatcc gtcagaaccg catctacaag      900

attctggaac tgaaccacta cgacccagcg tacgtgggga gtattttggt cgggtggtgc      960

cagaagaaat ggggcaagcg aaacacgctg tggctgttcg gacatgcgac caccggcaag     1020

accaacatcg cggaggctat tgcccatgct gtgccgttct atggatgcgt taactggacc     1080

aacgagaact ttccgttcaa cgactgcgtc gaaaaaatga ttatctggtg ggaggagggc     1140

aaaatgaccg ccaaagtggt ggaaacagcc aaggcgattc tgggaggatc tcgggtgaga     1200

gtggaccaaa aatgcaaagc ttcggttccg atcgaaccga cgccggtcat tattaccagt     1260

aacaccaaca tgtgttatgt catcgacggg aacacgacca cgttcgagca taagcagccg     1320

ttggaggaca ggatgtttaa gctcgaattg ctgactcggt tgcctgatga ctttggtaag     1380

gtgaccaaac aggaggtgcg tcaattcttc aggtggtctc aggatcacct gacccctgtg     1440

atcccagaat tcctagtgcg gaaggcggag tctcgcaaaa gacccgcccc ttccggggaa     1500

ggctatataa gcccgacaaa gcggcccgcg ctcgcagagc agcagcaggc gtcggagagc     1560

gcggacccgg ttcccaccag gtatcgtatc aaatgctcga aacattgcgg tatggataaa     1620

atgttgtttc cttgccaaat ttgtgaatcg atgaacagag atattaatat ttgtgctatt     1680

cataaaacga ccgactgtaa agagtgtttc cccgactacg gggataaaga tgatgtagaa     1740

ctacccccct gtacagaaca caacgtgtct cgttgttatc aatgtcattc gggcgaattg     1800

tatcgcgtga cttcggactc tgacgagaaa cctgcccccg agagtgatga aggcaccgag     1860

ccatcctatg ctccctgcac gattcaccac ctgatgggca agagtcacgg gttagtcact     1920

tgcgcggcgt gtcggttgaa aaatagtacg ttgcatgatg acttggatga cggtgatctc     1980

gaacaataa                                                             1989


<210> 5178
<211> 1626
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5178
atgaggtcgt actacgaggt catcgttcag ctgcccaacg acgtcgagag tcaggtacct       60

ggaatctccg attcgttcgt caactggatt acgtcgcgag aatggacgtt gcctgaggac      120

gccgattggg atttggacca ggtcgatcaa gttcaactga cgctcggcga caaaatccaa      180

cgggagattc gaactcattg ggggacgatg gccaaagaac cggactttca ctattttatc      240

caactggaac aaggtgaggt gttctttcat ttacacgtcc tgctggaaac gtgttccgta      300

aagccgatgg tactcggaag atatatccga catattcaac aaaaaattgt gagtaaagtc      360

tactgcgcca cgagcctacg atggaaggat ggatgcgtgg tgaccaagac caaaaatttc      420

gggggcgcga acaaggtccg ggccgagtcg tatattcccg cctacctgat cccgaaacag      480

caaccggaag tgcagtgggc gtggactaac gtgcccgagt atataaaagc gtgcttgcac      540

cgagaactgc gtgccagtct cgcgcgactt cacttcgagg aggcgggcgt ctcgcaatcc      600

aaggaaaatc tcgcgagaac tgcagacggc gctcccgtga tgccgacccg cgtcagcaaa      660

cgctacatgg agctcgtgga ttggctcgtg gagaagggga tcaccaccga gaaggaatgg      720

ctgctggaaa acagagaaag ctttcggagc tttcaggcct cgagcaactc ggcgcgtcag      780

atcaagacgg ccctgcaagg cgccattcag gagatgcttc tgaccaagac ggcggaggac      840

tacctcgtcg gaaaggatcc cgtctcggac gacgacatcc gtcagaaccg catctacaag      900

attctggaac tgaaccacta cgacccagcg tacgtgggga gtattttggt cgggtggtgc      960

cagaagaaat ggggcaagcg aaacacgctg tggctgttcg gacatgcgac caccggcaag     1020

accaacatcg cggaggctat tgcccatgct gtgccgttct atggatgcgt taactggacc     1080

aacgagaact ttccgttcaa cgactgcgtc gaaaaaatga ttatctggtg ggaggagggc     1140

aaaatgaccg ccaaagtggt ggaaacagcc aaggcgattc tgggaggatc tcgggtgaga     1200

gtggaccaaa aatgcaaagc ttcggttccg atcgaaccga cgccggtcat tattaccagt     1260

aacaccaaca tgtgttatgt catcgacggg aacacgacca cgttcgagca taagcagccg     1320

ttggaggaca ggatgtttaa gctcgaattg ctgactcggt tgcctgatga ctttggtaag     1380

gtgaccaaac aggaggtgcg tcaattcttc aggtggtctc aggatcacct gacccctgtg     1440

atcccagaat tcctagtgcg gaaggcggag tctcgcaaaa gacccgcccc ttccggggaa     1500

ggctatataa gcccgacaaa gcggcccgcg ctcgcagagc agcagcaggc gtcggagagc     1560

gcggacccgg ttcccaccag attggttgga gcggttggtc aaaaagggag tgaatgctgc     1620

agctga                                                                1626


<210> 5179
<211> 1323
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5179
atggagctcg tggattggct cgtggagaag gggatcacca ccgagaagga atggctgctg       60

gaaaacagag aaagctttcg gagctttcag gcctcgagca actcggcgcg tcagatcaag      120

acggccctgc aaggcgccat tcaggagatg cttctgacca agacggcgga ggactacctc      180

gtcggaaagg atcccgtctc ggacgacgac atccgtcaga accgcatcta caagattctg      240

gaactgaacc actacgaccc agcgtacgtg gggagtattt tggtcgggtg gtgccagaag      300

aaatggggca agcgaaacac gctgtggctg ttcggacatg cgaccaccgg caagaccaac      360

atcgcggagg ctattgccca tgctgtgccg ttctatggat gcgttaactg gaccaacgag      420

aactttccgt tcaacgactg cgtcgaaaaa atgattatct ggtgggagga gggcaaaatg      480

accgccaaag tggtggaaac agccaaggcg attctgggag gatctcgggt gagagtggac      540

caaaaatgca aagcttcggt tccgatcgaa ccgacgccgg tcattattac cagtaacacc      600

aacatgtgtt atgtcatcga cgggaacacg accacgttcg agcataagca gccgttggag      660

gacaggatgt ttaagctcga attgctgact cggttgcctg atgactttgg taaggtgacc      720

aaacaggagg tgcgtcaatt cttcaggtgg tctcaggatc acctgacccc tgtgatccca      780

gaattcctag tgcggaaggc ggagtctcgc aaaagacccg ccccttccgg ggaaggctat      840

ataagcccga caaagcggcc cgcgctcgca gagcagcagc aggcgtcgga gagcgcggac      900

ccggttccca ccaggtatcg tatcaaatgc tcgaaacatt gcggtatgga taaaatgttg      960

tttccttgcc aaatttgtga atcgatgaac agagatatta atatttgtgc tattcataaa     1020

acgaccgact gtaaagagtg tttccccgac tacggggata aagatgatgt agaactaccc     1080

ccctgtacag aacacaacgt gtctcgttgt tatcaatgtc attcgggcga attgtatcgc     1140

gtgacttcgg actctgacga gaaacctgcc cccgagagtg atgaaggcac cgagccatcc     1200

tatgctccct gcacgattca ccacctgatg ggcaagagtc acgggttagt cacttgcgcg     1260

gcgtgtcggt tgaaaaatag tacgttgcat gatgacttgg atgacggtga tctcgaacaa     1320

taa                                                                   1323


<210> 5180
<211> 960
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5180
atggagctcg tggattggct cgtggagaag gggatcacca ccgagaagga atggctgctg       60

gaaaacagag aaagctttcg gagctttcag gcctcgagca actcggcgcg tcagatcaag      120

acggccctgc aaggcgccat tcaggagatg cttctgacca agacggcgga ggactacctc      180

gtcggaaagg atcccgtctc ggacgacgac atccgtcaga accgcatcta caagattctg      240

gaactgaacc actacgaccc agcgtacgtg gggagtattt tggtcgggtg gtgccagaag      300

aaatggggca agcgaaacac gctgtggctg ttcggacatg cgaccaccgg caagaccaac      360

atcgcggagg ctattgccca tgctgtgccg ttctatggat gcgttaactg gaccaacgag      420

aactttccgt tcaacgactg cgtcgaaaaa atgattatct ggtgggagga gggcaaaatg      480

accgccaaag tggtggaaac agccaaggcg attctgggag gatctcgggt gagagtggac      540

caaaaatgca aagcttcggt tccgatcgaa ccgacgccgg tcattattac cagtaacacc      600

aacatgtgtt atgtcatcga cgggaacacg accacgttcg agcataagca gccgttggag      660

gacaggatgt ttaagctcga attgctgact cggttgcctg atgactttgg taaggtgacc      720

aaacaggagg tgcgtcaatt cttcaggtgg tctcaggatc acctgacccc tgtgatccca      780

gaattcctag tgcggaaggc ggagtctcgc aaaagacccg ccccttccgg ggaaggctat      840

ataagcccga caaagcggcc cgcgctcgca gagcagcagc aggcgtcgga gagcgcggac      900

ccggttccca ccagattggt tggagcggtt ggtcaaaaag ggagtgaatg ctgcagctga      960


<210> 5181
<211> 1608
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5181
atggctgaag gaggtggcgg cccagtgggc gatgcaggcc agggtgccga tggagtgggc       60

aattcctccg gaaattggca ttgcgattcc caatggctgg aaaacggagt cgtcactcga      120

accacccgaa cctgggtctt gcccagctac aacaaccacc tgtacaaacg aatccaagga      180

cccagcggag gcgacaacaa caacaaattc tttggattca gcaccccctg gggatacttt      240

gactacaatc gattccactg ccacttttcc ccgcgagact ggcaacgact catcaacaac      300

aactggggca tccgtcccaa agcgatgcgc tttagactct ttaacatcca ggttaaagag      360

gtcacggtcc aagacttcaa caccaccatc ggcaacaacc tcaccagtac ggtccaggtc      420

tttgcggaca aggactacca actgccgtac gtcctcggat cggctaccga aggcaccttc      480

ccgccgttcc cagcggatat ctacacgatc ccgcagtacg ggtactgcac gctaaactac      540

aacaacgagg cggtggatcg ttcggccttc tactgtctgg actactttcc ctcagacatg      600

ctgcggacag gaaataactt tgagtttact tacaccttcg aggacgttcc tttccatagc      660

atgtttgccc acaaccagac gctagaccgg ctgatgaatc ccctcgtgga tcagtacctc      720

tgggctttca gctccgtcag ccaagcaggc tcatctggac gagctcttca ttactcgcgg      780

gcgactaaaa ccaacatggc ggctcaatat aggaactggt tacctgggcc tttcttccgt      840

gatcagcaaa tctttacggg cgctagcaac atcactaaaa ataacgtctt tagcgtttgg      900

gaaaaaggca agcaatggga actcgacaat cggaccaacc taatgcagcc cggtcctgcg      960

gcagcgacca cctttagcgg agaacctgac cgtcaagcca tgcaaaacac gctggctttt     1020

agcaggaccg tctacgatca aacgaccgcc acgaccgatc gtaaccagat actcatcacc     1080

aacgaagacg aaatcagacc caccaactcg gtcggtatcg acgcgtgggg agcagttccc     1140

accaacaacc agtcgatcgt gacccccggc actcgcgcgg ccgtcaacaa tcaaggggcg     1200

cttcccggga tggtgtggca aaacagagac atttacccta cagggaccca tttggccaaa     1260

attcccgaca ctgacaatca cttccatccg tccccgctta ttgggcggtt tggctgcaag     1320

catccccctc cccagatttt cattaaaaac acacccgtcc ctgccaaccc ttcggaaacg     1380

ttccagacgg ccaaagtggc ctccttcatc aaccagtact cgaccggaca gtgcaccgtc     1440

gaaatctttt gggaactcaa gaaggaaacc tccaagcgct ggaaccccga aatccagttc     1500

acctccaact ttggcaacgc ggccgacatc cagtttgccg tctccgacac gggatcctat     1560

tccgaacctc gtcccatcgg tacccgttac cttaccaaac ctctgtaa                  1608


<210> 5182
<211> 2232
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5182
atgtctctca tttctgatgc gattccagat tggttggagc ggttggtcaa aaagggagtg       60

aatgctgcag ctgatttcta ccatttggaa agcggtcctc ctcgtcctaa ggcaaatcag      120

caaactcaag aatctcttga aaaggacgat tcgagaggtc tcgtgttccc aggctacaat      180

tatctaggcc ctttcaacgg tctagataaa ggagaacccg tcaacgaggc agacgctgcc      240

gccttagaac acgacaaggc ttacgacctc gaaatcaagg acgggcacaa cccgtacttt      300

gagtacaacg aggccgacag acgtttccag gaacgtctca aagacgatac ctcctttgga      360

ggcaatttag gtaaagccat cttccaggcc aaaaagaggg ttctcgaacc ctttggtctg      420

gtggaagact caaagacggc tccgaccgga gacaagcgga aaggcgaaga cgaacctcgt      480

ttgcccgaca cttcttcaca gactcccaag aaaaacaaga agcctcgcaa ggaaagacct      540

tccggcgggg cagaagatcc gggcgaaggc acctcttcca acgctggagc agcagcaccc      600

gcctctagtg tgggatcatc tatcatggct gaaggaggtg gcggcccagt gggcgatgca      660

ggccagggtg ccgatggagt gggcaattcc tccggaaatt ggcattgcga ttcccaatgg      720

ctggaaaacg gagtcgtcac tcgaaccacc cgaacctggg tcttgcccag ctacaacaac      780

cacctgtaca aacgaatcca aggacccagc ggaggcgaca acaacaacaa attctttgga      840

ttcagcaccc cctggggata ctttgactac aatcgattcc actgccactt ttccccgcga      900

gactggcaac gactcatcaa caacaactgg ggcatccgtc ccaaagcgat gcgctttaga      960

ctctttaaca tccaggttaa agaggtcacg gtccaagact tcaacaccac catcggcaac     1020

aacctcacca gtacggtcca ggtctttgcg gacaaggact accaactgcc gtacgtcctc     1080

ggatcggcta ccgaaggcac cttcccgccg ttcccagcgg atatctacac gatcccgcag     1140

tacgggtact gcacgctaaa ctacaacaac gaggcggtgg atcgttcggc cttctactgt     1200

ctggactact ttccctcaga catgctgcgg acaggaaata actttgagtt tacttacacc     1260

ttcgaggacg ttcctttcca tagcatgttt gcccacaacc agacgctaga ccggctgatg     1320

aatcccctcg tggatcagta cctctgggct ttcagctccg tcagccaagc aggctcatct     1380

ggacgagctc ttcattactc gcgggcgact aaaaccaaca tggcggctca atataggaac     1440

tggttacctg ggcctttctt ccgtgatcag caaatcttta cgggcgctag caacatcact     1500

aaaaataacg tctttagcgt ttgggaaaaa ggcaagcaat gggaactcga caatcggacc     1560

aacctaatgc agcccggtcc tgcggcagcg accaccttta gcggagaacc tgaccgtcaa     1620

gccatgcaaa acacgctggc ttttagcagg accgtctacg atcaaacgac cgccacgacc     1680

gatcgtaacc agatactcat caccaacgaa gacgaaatca gacccaccaa ctcggtcggt     1740

atcgacgcgt ggggagcagt tcccaccaac aaccagtcga tcgtgacccc cggcactcgc     1800

gcggccgtca acaatcaagg ggcgcttccc gggatggtgt ggcaaaacag agacatttac     1860

cctacaggga cccatttggc caaaattccc gacactgaca atcacttcca tccgtccccg     1920

cttattgggc ggtttggctg caagcatccc cctccccaga ttttcattaa aaacacaccc     1980

gtccctgcca acccttcgga aacgttccag acggccaaag tggcctcctt catcaaccag     2040

tactcgaccg gacagtgcac cgtcgaaatc ttttgggaac tcaagaagga aacctccaag     2100

cgctggaacc ccgaaatcca gttcacctcc aactttggca acgcggccga catccagttt     2160

gccgtctccg acacgggatc ctattccgaa cctcgtccca tcggtacccg ttaccttacc     2220

aaacctctgt aa                                                         2232


<210> 5183
<211> 535
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5183
Met Ala Glu Gly Gly Gly Gly Pro Val Gly Asp Ala Gly Gln Gly Ala 
1               5                   10                  15      


Asp Gly Val Gly Asn Ser Ser Gly Asn Trp His Cys Asp Ser Gln Trp 
            20                  25                  30          


Leu Glu Asn Gly Val Val Thr Arg Thr Thr Arg Thr Trp Val Leu Pro 
        35                  40                  45              


Ser Tyr Asn Asn His Leu Tyr Lys Arg Ile Gln Gly Pro Ser Gly Gly 
    50                  55                  60                  


Asp Asn Asn Asn Lys Phe Phe Gly Phe Ser Thr Pro Trp Gly Tyr Phe 
65                  70                  75                  80  


Asp Tyr Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg 
                85                  90                  95      


Leu Ile Asn Asn Asn Trp Gly Ile Arg Pro Lys Ala Met Arg Phe Arg 
            100                 105                 110         


Leu Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Phe Asn Thr 
        115                 120                 125             


Thr Ile Gly Asn Asn Leu Thr Ser Thr Val Gln Val Phe Ala Asp Lys 
    130                 135                 140                 


Asp Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala Thr Glu Gly Thr Phe 
145                 150                 155                 160 


Pro Pro Phe Pro Ala Asp Ile Tyr Thr Ile Pro Gln Tyr Gly Tyr Cys 
                165                 170                 175     


Thr Leu Asn Tyr Asn Asn Glu Ala Val Asp Arg Ser Ala Phe Tyr Cys 
            180                 185                 190         


Leu Asp Tyr Phe Pro Ser Asp Met Leu Arg Thr Gly Asn Asn Phe Glu 
        195                 200                 205             


Phe Thr Tyr Thr Phe Glu Asp Val Pro Phe His Ser Met Phe Ala His 
    210                 215                 220                 


Asn Gln Thr Leu Asp Arg Leu Met Asn Pro Leu Val Asp Gln Tyr Leu 
225                 230                 235                 240 


Trp Ala Phe Ser Ser Val Ser Gln Ala Gly Ser Ser Gly Arg Ala Leu 
                245                 250                 255     


His Tyr Ser Arg Ala Thr Lys Thr Asn Met Ala Ala Gln Tyr Arg Asn 
            260                 265                 270         


Trp Leu Pro Gly Pro Phe Phe Arg Asp Gln Gln Ile Phe Thr Gly Ala 
        275                 280                 285             


Ser Asn Ile Thr Lys Asn Asn Val Phe Ser Val Trp Glu Lys Gly Lys 
    290                 295                 300                 


Gln Trp Glu Leu Asp Asn Arg Thr Asn Leu Met Gln Pro Gly Pro Ala 
305                 310                 315                 320 


Ala Ala Thr Thr Phe Ser Gly Glu Pro Asp Arg Gln Ala Met Gln Asn 
                325                 330                 335     


Thr Leu Ala Phe Ser Arg Thr Val Tyr Asp Gln Thr Thr Ala Thr Thr 
            340                 345                 350         


Asp Arg Asn Gln Ile Leu Ile Thr Asn Glu Asp Glu Ile Arg Pro Thr 
        355                 360                 365             


Asn Ser Val Gly Ile Asp Ala Trp Gly Ala Val Pro Thr Asn Asn Gln 
    370                 375                 380                 


Ser Ile Val Thr Pro Gly Thr Arg Ala Ala Val Asn Asn Gln Gly Ala 
385                 390                 395                 400 


Leu Pro Gly Met Val Trp Gln Asn Arg Asp Ile Tyr Pro Thr Gly Thr 
                405                 410                 415     


His Leu Ala Lys Ile Pro Asp Thr Asp Asn His Phe His Pro Ser Pro 
            420                 425                 430         


Leu Ile Gly Arg Phe Gly Cys Lys His Pro Pro Pro Gln Ile Phe Ile 
        435                 440                 445             


Lys Asn Thr Pro Val Pro Ala Asn Pro Ser Glu Thr Phe Gln Thr Ala 
    450                 455                 460                 


Lys Val Ala Ser Phe Ile Asn Gln Tyr Ser Thr Gly Gln Cys Thr Val 
465                 470                 475                 480 


Glu Ile Phe Trp Glu Leu Lys Lys Glu Thr Ser Lys Arg Trp Asn Pro 
                485                 490                 495     


Glu Ile Gln Phe Thr Ser Asn Phe Gly Asn Ala Ala Asp Ile Gln Phe 
            500                 505                 510         


Ala Val Ser Asp Thr Gly Ser Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
        515                 520                 525             


Arg Tyr Leu Thr Lys Pro Leu 
    530                 535 


<210> 5184
<211> 440
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5184
Met Glu Leu Val Asp Trp Leu Val Glu Lys Gly Ile Thr Thr Glu Lys 
1               5                   10                  15      


Glu Trp Leu Leu Glu Asn Arg Glu Ser Phe Arg Ser Phe Gln Ala Ser 
            20                  25                  30          


Ser Asn Ser Ala Arg Gln Ile Lys Thr Ala Leu Gln Gly Ala Ile Gln 
        35                  40                  45              


Glu Met Leu Leu Thr Lys Thr Ala Glu Asp Tyr Leu Val Gly Lys Asp 
    50                  55                  60                  


Pro Val Ser Asp Asp Asp Ile Arg Gln Asn Arg Ile Tyr Lys Ile Leu 
65                  70                  75                  80  


Glu Leu Asn His Tyr Asp Pro Ala Tyr Val Gly Ser Ile Leu Val Gly 
                85                  90                  95      


Trp Cys Gln Lys Lys Trp Gly Lys Arg Asn Thr Leu Trp Leu Phe Gly 
            100                 105                 110         


His Ala Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Ala 
        115                 120                 125             


Val Pro Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe 
    130                 135                 140                 


Asn Asp Cys Val Glu Lys Met Ile Ile Trp Trp Glu Glu Gly Lys Met 
145                 150                 155                 160 


Thr Ala Lys Val Val Glu Thr Ala Lys Ala Ile Leu Gly Gly Ser Arg 
                165                 170                 175     


Val Arg Val Asp Gln Lys Cys Lys Ala Ser Val Pro Ile Glu Pro Thr 
            180                 185                 190         


Pro Val Ile Ile Thr Ser Asn Thr Asn Met Cys Tyr Val Ile Asp Gly 
        195                 200                 205             


Asn Thr Thr Thr Phe Glu His Lys Gln Pro Leu Glu Asp Arg Met Phe 
    210                 215                 220                 


Lys Leu Glu Leu Leu Thr Arg Leu Pro Asp Asp Phe Gly Lys Val Thr 
225                 230                 235                 240 


Lys Gln Glu Val Arg Gln Phe Phe Arg Trp Ser Gln Asp His Leu Thr 
                245                 250                 255     


Pro Val Ile Pro Glu Phe Leu Val Arg Lys Ala Glu Ser Arg Lys Arg 
            260                 265                 270         


Pro Ala Pro Ser Gly Glu Gly Tyr Ile Ser Pro Thr Lys Arg Pro Ala 
        275                 280                 285             


Leu Ala Glu Gln Gln Gln Ala Ser Glu Ser Ala Asp Pro Val Pro Thr 
    290                 295                 300                 


Arg Tyr Arg Ile Lys Cys Ser Lys His Cys Gly Met Asp Lys Met Leu 
305                 310                 315                 320 


Phe Pro Cys Gln Ile Cys Glu Ser Met Asn Arg Asp Ile Asn Ile Cys 
                325                 330                 335     


Ala Ile His Lys Thr Thr Asp Cys Lys Glu Cys Phe Pro Asp Tyr Gly 
            340                 345                 350         


Asp Lys Asp Asp Val Glu Leu Pro Pro Cys Thr Glu His Asn Val Ser 
        355                 360                 365             


Arg Cys Tyr Gln Cys His Ser Gly Glu Leu Tyr Arg Val Thr Ser Asp 
    370                 375                 380                 


Ser Asp Glu Lys Pro Ala Pro Glu Ser Asp Glu Gly Thr Glu Pro Ser 
385                 390                 395                 400 


Tyr Ala Pro Cys Thr Ile His His Leu Met Gly Lys Ser His Gly Leu 
                405                 410                 415     


Val Thr Cys Ala Ala Cys Arg Leu Lys Asn Ser Thr Leu His Asp Asp 
            420                 425                 430         


Leu Asp Asp Gly Asp Leu Glu Gln 
        435                 440 


<210> 5185
<211> 319
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5185
Met Glu Leu Val Asp Trp Leu Val Glu Lys Gly Ile Thr Thr Glu Lys 
1               5                   10                  15      


Glu Trp Leu Leu Glu Asn Arg Glu Ser Phe Arg Ser Phe Gln Ala Ser 
            20                  25                  30          


Ser Asn Ser Ala Arg Gln Ile Lys Thr Ala Leu Gln Gly Ala Ile Gln 
        35                  40                  45              


Glu Met Leu Leu Thr Lys Thr Ala Glu Asp Tyr Leu Val Gly Lys Asp 
    50                  55                  60                  


Pro Val Ser Asp Asp Asp Ile Arg Gln Asn Arg Ile Tyr Lys Ile Leu 
65                  70                  75                  80  


Glu Leu Asn His Tyr Asp Pro Ala Tyr Val Gly Ser Ile Leu Val Gly 
                85                  90                  95      


Trp Cys Gln Lys Lys Trp Gly Lys Arg Asn Thr Leu Trp Leu Phe Gly 
            100                 105                 110         


His Ala Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Ala 
        115                 120                 125             


Val Pro Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe 
    130                 135                 140                 


Asn Asp Cys Val Glu Lys Met Ile Ile Trp Trp Glu Glu Gly Lys Met 
145                 150                 155                 160 


Thr Ala Lys Val Val Glu Thr Ala Lys Ala Ile Leu Gly Gly Ser Arg 
                165                 170                 175     


Val Arg Val Asp Gln Lys Cys Lys Ala Ser Val Pro Ile Glu Pro Thr 
            180                 185                 190         


Pro Val Ile Ile Thr Ser Asn Thr Asn Met Cys Tyr Val Ile Asp Gly 
        195                 200                 205             


Asn Thr Thr Thr Phe Glu His Lys Gln Pro Leu Glu Asp Arg Met Phe 
    210                 215                 220                 


Lys Leu Glu Leu Leu Thr Arg Leu Pro Asp Asp Phe Gly Lys Val Thr 
225                 230                 235                 240 


Lys Gln Glu Val Arg Gln Phe Phe Arg Trp Ser Gln Asp His Leu Thr 
                245                 250                 255     


Pro Val Ile Pro Glu Phe Leu Val Arg Lys Ala Glu Ser Arg Lys Arg 
            260                 265                 270         


Pro Ala Pro Ser Gly Glu Gly Tyr Ile Ser Pro Thr Lys Arg Pro Ala 
        275                 280                 285             


Leu Ala Glu Gln Gln Gln Ala Ser Glu Ser Ala Asp Pro Val Pro Thr 
    290                 295                 300                 


Arg Leu Val Gly Ala Val Gly Gln Lys Gly Ser Glu Cys Cys Ser 
305                 310                 315                 


<210> 5186
<211> 662
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5186
Met Arg Ser Tyr Tyr Glu Val Ile Val Gln Leu Pro Asn Asp Val Glu 
1               5                   10                  15      


Ser Gln Val Pro Gly Ile Ser Asp Ser Phe Val Asn Trp Ile Thr Ser 
            20                  25                  30          


Arg Glu Trp Thr Leu Pro Glu Asp Ala Asp Trp Asp Leu Asp Gln Val 
        35                  40                  45              


Asp Gln Val Gln Leu Thr Leu Gly Asp Lys Ile Gln Arg Glu Ile Arg 
    50                  55                  60                  


Thr His Trp Gly Thr Met Ala Lys Glu Pro Asp Phe His Tyr Phe Ile 
65                  70                  75                  80  


Gln Leu Glu Gln Gly Glu Val Phe Phe His Leu His Val Leu Leu Glu 
                85                  90                  95      


Thr Cys Ser Val Lys Pro Met Val Leu Gly Arg Tyr Ile Arg His Ile 
            100                 105                 110         


Gln Gln Lys Ile Val Ser Lys Val Tyr Cys Ala Thr Ser Leu Arg Trp 
        115                 120                 125             


Lys Asp Gly Cys Val Val Thr Lys Thr Lys Asn Phe Gly Gly Ala Asn 
    130                 135                 140                 


Lys Val Arg Ala Glu Ser Tyr Ile Pro Ala Tyr Leu Ile Pro Lys Gln 
145                 150                 155                 160 


Gln Pro Glu Val Gln Trp Ala Trp Thr Asn Val Pro Glu Tyr Ile Lys 
                165                 170                 175     


Ala Cys Leu His Arg Glu Leu Arg Ala Ser Leu Ala Arg Leu His Phe 
            180                 185                 190         


Glu Glu Ala Gly Val Ser Gln Ser Lys Glu Asn Leu Ala Arg Thr Ala 
        195                 200                 205             


Asp Gly Ala Pro Val Met Pro Thr Arg Val Ser Lys Arg Tyr Met Glu 
    210                 215                 220                 


Leu Val Asp Trp Leu Val Glu Lys Gly Ile Thr Thr Glu Lys Glu Trp 
225                 230                 235                 240 


Leu Leu Glu Asn Arg Glu Ser Phe Arg Ser Phe Gln Ala Ser Ser Asn 
                245                 250                 255     


Ser Ala Arg Gln Ile Lys Thr Ala Leu Gln Gly Ala Ile Gln Glu Met 
            260                 265                 270         


Leu Leu Thr Lys Thr Ala Glu Asp Tyr Leu Val Gly Lys Asp Pro Val 
        275                 280                 285             


Ser Asp Asp Asp Ile Arg Gln Asn Arg Ile Tyr Lys Ile Leu Glu Leu 
    290                 295                 300                 


Asn His Tyr Asp Pro Ala Tyr Val Gly Ser Ile Leu Val Gly Trp Cys 
305                 310                 315                 320 


Gln Lys Lys Trp Gly Lys Arg Asn Thr Leu Trp Leu Phe Gly His Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Ala Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Glu Lys Met Ile Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Thr Ala Lys Ala Ile Leu Gly Gly Ser Arg Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ala Ser Val Pro Ile Glu Pro Thr Pro Val 
                405                 410                 415     


Ile Ile Thr Ser Asn Thr Asn Met Cys Tyr Val Ile Asp Gly Asn Thr 
            420                 425                 430         


Thr Thr Phe Glu His Lys Gln Pro Leu Glu Asp Arg Met Phe Lys Leu 
        435                 440                 445             


Glu Leu Leu Thr Arg Leu Pro Asp Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Arg Gln Phe Phe Arg Trp Ser Gln Asp His Leu Thr Pro Val 
465                 470                 475                 480 


Ile Pro Glu Phe Leu Val Arg Lys Ala Glu Ser Arg Lys Arg Pro Ala 
                485                 490                 495     


Pro Ser Gly Glu Gly Tyr Ile Ser Pro Thr Lys Arg Pro Ala Leu Ala 
            500                 505                 510         


Glu Gln Gln Gln Ala Ser Glu Ser Ala Asp Pro Val Pro Thr Arg Tyr 
        515                 520                 525             


Arg Ile Lys Cys Ser Lys His Cys Gly Met Asp Lys Met Leu Phe Pro 
    530                 535                 540                 


Cys Gln Ile Cys Glu Ser Met Asn Arg Asp Ile Asn Ile Cys Ala Ile 
545                 550                 555                 560 


His Lys Thr Thr Asp Cys Lys Glu Cys Phe Pro Asp Tyr Gly Asp Lys 
                565                 570                 575     


Asp Asp Val Glu Leu Pro Pro Cys Thr Glu His Asn Val Ser Arg Cys 
            580                 585                 590         


Tyr Gln Cys His Ser Gly Glu Leu Tyr Arg Val Thr Ser Asp Ser Asp 
        595                 600                 605             


Glu Lys Pro Ala Pro Glu Ser Asp Glu Gly Thr Glu Pro Ser Tyr Ala 
    610                 615                 620                 


Pro Cys Thr Ile His His Leu Met Gly Lys Ser His Gly Leu Val Thr 
625                 630                 635                 640 


Cys Ala Ala Cys Arg Leu Lys Asn Ser Thr Leu His Asp Asp Leu Asp 
                645                 650                 655     


Asp Gly Asp Leu Glu Gln 
            660         


<210> 5187
<211> 541
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5187
Met Arg Ser Tyr Tyr Glu Val Ile Val Gln Leu Pro Asn Asp Val Glu 
1               5                   10                  15      


Ser Gln Val Pro Gly Ile Ser Asp Ser Phe Val Asn Trp Ile Thr Ser 
            20                  25                  30          


Arg Glu Trp Thr Leu Pro Glu Asp Ala Asp Trp Asp Leu Asp Gln Val 
        35                  40                  45              


Asp Gln Val Gln Leu Thr Leu Gly Asp Lys Ile Gln Arg Glu Ile Arg 
    50                  55                  60                  


Thr His Trp Gly Thr Met Ala Lys Glu Pro Asp Phe His Tyr Phe Ile 
65                  70                  75                  80  


Gln Leu Glu Gln Gly Glu Val Phe Phe His Leu His Val Leu Leu Glu 
                85                  90                  95      


Thr Cys Ser Val Lys Pro Met Val Leu Gly Arg Tyr Ile Arg His Ile 
            100                 105                 110         


Gln Gln Lys Ile Val Ser Lys Val Tyr Cys Ala Thr Ser Leu Arg Trp 
        115                 120                 125             


Lys Asp Gly Cys Val Val Thr Lys Thr Lys Asn Phe Gly Gly Ala Asn 
    130                 135                 140                 


Lys Val Arg Ala Glu Ser Tyr Ile Pro Ala Tyr Leu Ile Pro Lys Gln 
145                 150                 155                 160 


Gln Pro Glu Val Gln Trp Ala Trp Thr Asn Val Pro Glu Tyr Ile Lys 
                165                 170                 175     


Ala Cys Leu His Arg Glu Leu Arg Ala Ser Leu Ala Arg Leu His Phe 
            180                 185                 190         


Glu Glu Ala Gly Val Ser Gln Ser Lys Glu Asn Leu Ala Arg Thr Ala 
        195                 200                 205             


Asp Gly Ala Pro Val Met Pro Thr Arg Val Ser Lys Arg Tyr Met Glu 
    210                 215                 220                 


Leu Val Asp Trp Leu Val Glu Lys Gly Ile Thr Thr Glu Lys Glu Trp 
225                 230                 235                 240 


Leu Leu Glu Asn Arg Glu Ser Phe Arg Ser Phe Gln Ala Ser Ser Asn 
                245                 250                 255     


Ser Ala Arg Gln Ile Lys Thr Ala Leu Gln Gly Ala Ile Gln Glu Met 
            260                 265                 270         


Leu Leu Thr Lys Thr Ala Glu Asp Tyr Leu Val Gly Lys Asp Pro Val 
        275                 280                 285             


Ser Asp Asp Asp Ile Arg Gln Asn Arg Ile Tyr Lys Ile Leu Glu Leu 
    290                 295                 300                 


Asn His Tyr Asp Pro Ala Tyr Val Gly Ser Ile Leu Val Gly Trp Cys 
305                 310                 315                 320 


Gln Lys Lys Trp Gly Lys Arg Asn Thr Leu Trp Leu Phe Gly His Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Ala Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Glu Lys Met Ile Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Thr Ala Lys Ala Ile Leu Gly Gly Ser Arg Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ala Ser Val Pro Ile Glu Pro Thr Pro Val 
                405                 410                 415     


Ile Ile Thr Ser Asn Thr Asn Met Cys Tyr Val Ile Asp Gly Asn Thr 
            420                 425                 430         


Thr Thr Phe Glu His Lys Gln Pro Leu Glu Asp Arg Met Phe Lys Leu 
        435                 440                 445             


Glu Leu Leu Thr Arg Leu Pro Asp Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Arg Gln Phe Phe Arg Trp Ser Gln Asp His Leu Thr Pro Val 
465                 470                 475                 480 


Ile Pro Glu Phe Leu Val Arg Lys Ala Glu Ser Arg Lys Arg Pro Ala 
                485                 490                 495     


Pro Ser Gly Glu Gly Tyr Ile Ser Pro Thr Lys Arg Pro Ala Leu Ala 
            500                 505                 510         


Glu Gln Gln Gln Ala Ser Glu Ser Ala Asp Pro Val Pro Thr Arg Leu 
        515                 520                 525             


Val Gly Ala Val Gly Gln Lys Gly Ser Glu Cys Cys Ser 
    530                 535                 540     


<210> 5188
<211> 743
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5188
Met Ser Leu Ile Ser Asp Ala Ile Pro Asp Trp Leu Glu Arg Leu Val 
1               5                   10                  15      


Lys Lys Gly Val Asn Ala Ala Ala Asp Phe Tyr His Leu Glu Ser Gly 
            20                  25                  30          


Pro Pro Arg Pro Lys Ala Asn Gln Gln Thr Gln Glu Ser Leu Glu Lys 
        35                  40                  45              


Asp Asp Ser Arg Gly Leu Val Phe Pro Gly Tyr Asn Tyr Leu Gly Pro 
    50                  55                  60                  


Phe Asn Gly Leu Asp Lys Gly Glu Pro Val Asn Glu Ala Asp Ala Ala 
65                  70                  75                  80  


Ala Leu Glu His Asp Lys Ala Tyr Asp Leu Glu Ile Lys Asp Gly His 
                85                  90                  95      


Asn Pro Tyr Phe Glu Tyr Asn Glu Ala Asp Arg Arg Phe Gln Glu Arg 
            100                 105                 110         


Leu Lys Asp Asp Thr Ser Phe Gly Gly Asn Leu Gly Lys Ala Ile Phe 
        115                 120                 125             


Gln Ala Lys Lys Arg Val Leu Glu Pro Phe Gly Leu Val Glu Asp Ser 
    130                 135                 140                 


Lys Thr Ala Pro Thr Gly Asp Lys Arg Lys Gly Glu Asp Glu Pro Arg 
145                 150                 155                 160 


Leu Pro Asp Thr Ser Ser Gln Thr Pro Lys Lys Asn Lys Lys Pro Arg 
                165                 170                 175     


Lys Glu Arg Pro Ser Gly Gly Ala Glu Asp Pro Gly Glu Gly Thr Ser 
            180                 185                 190         


Ser Asn Ala Gly Ala Ala Ala Pro Ala Ser Ser Val Gly Ser Ser Ile 
        195                 200                 205             


Met Ala Glu Gly Gly Gly Gly Pro Val Gly Asp Ala Gly Gln Gly Ala 
    210                 215                 220                 


Asp Gly Val Gly Asn Ser Ser Gly Asn Trp His Cys Asp Ser Gln Trp 
225                 230                 235                 240 


Leu Glu Asn Gly Val Val Thr Arg Thr Thr Arg Thr Trp Val Leu Pro 
                245                 250                 255     


Ser Tyr Asn Asn His Leu Tyr Lys Arg Ile Gln Gly Pro Ser Gly Gly 
            260                 265                 270         


Asp Asn Asn Asn Lys Phe Phe Gly Phe Ser Thr Pro Trp Gly Tyr Phe 
        275                 280                 285             


Asp Tyr Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg 
    290                 295                 300                 


Leu Ile Asn Asn Asn Trp Gly Ile Arg Pro Lys Ala Met Arg Phe Arg 
305                 310                 315                 320 


Leu Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Phe Asn Thr 
                325                 330                 335     


Thr Ile Gly Asn Asn Leu Thr Ser Thr Val Gln Val Phe Ala Asp Lys 
            340                 345                 350         


Asp Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala Thr Glu Gly Thr Phe 
        355                 360                 365             


Pro Pro Phe Pro Ala Asp Ile Tyr Thr Ile Pro Gln Tyr Gly Tyr Cys 
    370                 375                 380                 


Thr Leu Asn Tyr Asn Asn Glu Ala Val Asp Arg Ser Ala Phe Tyr Cys 
385                 390                 395                 400 


Leu Asp Tyr Phe Pro Ser Asp Met Leu Arg Thr Gly Asn Asn Phe Glu 
                405                 410                 415     


Phe Thr Tyr Thr Phe Glu Asp Val Pro Phe His Ser Met Phe Ala His 
            420                 425                 430         


Asn Gln Thr Leu Asp Arg Leu Met Asn Pro Leu Val Asp Gln Tyr Leu 
        435                 440                 445             


Trp Ala Phe Ser Ser Val Ser Gln Ala Gly Ser Ser Gly Arg Ala Leu 
    450                 455                 460                 


His Tyr Ser Arg Ala Thr Lys Thr Asn Met Ala Ala Gln Tyr Arg Asn 
465                 470                 475                 480 


Trp Leu Pro Gly Pro Phe Phe Arg Asp Gln Gln Ile Phe Thr Gly Ala 
                485                 490                 495     


Ser Asn Ile Thr Lys Asn Asn Val Phe Ser Val Trp Glu Lys Gly Lys 
            500                 505                 510         


Gln Trp Glu Leu Asp Asn Arg Thr Asn Leu Met Gln Pro Gly Pro Ala 
        515                 520                 525             


Ala Ala Thr Thr Phe Ser Gly Glu Pro Asp Arg Gln Ala Met Gln Asn 
    530                 535                 540                 


Thr Leu Ala Phe Ser Arg Thr Val Tyr Asp Gln Thr Thr Ala Thr Thr 
545                 550                 555                 560 


Asp Arg Asn Gln Ile Leu Ile Thr Asn Glu Asp Glu Ile Arg Pro Thr 
                565                 570                 575     


Asn Ser Val Gly Ile Asp Ala Trp Gly Ala Val Pro Thr Asn Asn Gln 
            580                 585                 590         


Ser Ile Val Thr Pro Gly Thr Arg Ala Ala Val Asn Asn Gln Gly Ala 
        595                 600                 605             


Leu Pro Gly Met Val Trp Gln Asn Arg Asp Ile Tyr Pro Thr Gly Thr 
    610                 615                 620                 


His Leu Ala Lys Ile Pro Asp Thr Asp Asn His Phe His Pro Ser Pro 
625                 630                 635                 640 


Leu Ile Gly Arg Phe Gly Cys Lys His Pro Pro Pro Gln Ile Phe Ile 
                645                 650                 655     


Lys Asn Thr Pro Val Pro Ala Asn Pro Ser Glu Thr Phe Gln Thr Ala 
            660                 665                 670         


Lys Val Ala Ser Phe Ile Asn Gln Tyr Ser Thr Gly Gln Cys Thr Val 
        675                 680                 685             


Glu Ile Phe Trp Glu Leu Lys Lys Glu Thr Ser Lys Arg Trp Asn Pro 
    690                 695                 700                 


Glu Ile Gln Phe Thr Ser Asn Phe Gly Asn Ala Ala Asp Ile Gln Phe 
705                 710                 715                 720 


Ala Val Ser Asp Thr Gly Ser Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
                725                 730                 735     


Arg Tyr Leu Thr Lys Pro Leu 
            740             


<210> 5189
<211> 598
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5189
Thr Ala Pro Thr Gly Asp Lys Arg Lys Gly Glu Asp Glu Pro Arg Leu 
1               5                   10                  15      


Pro Asp Thr Ser Ser Gln Thr Pro Lys Lys Asn Lys Lys Pro Arg Lys 
            20                  25                  30          


Glu Arg Pro Ser Gly Gly Ala Glu Asp Pro Gly Glu Gly Thr Ser Ser 
        35                  40                  45              


Asn Ala Gly Ala Ala Ala Pro Ala Ser Ser Val Gly Ser Ser Ile Met 
    50                  55                  60                  


Ala Glu Gly Gly Gly Gly Pro Val Gly Asp Ala Gly Gln Gly Ala Asp 
65                  70                  75                  80  


Gly Val Gly Asn Ser Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu 
                85                  90                  95      


Glu Asn Gly Val Val Thr Arg Thr Thr Arg Thr Trp Val Leu Pro Ser 
            100                 105                 110         


Tyr Asn Asn His Leu Tyr Lys Arg Ile Gln Gly Pro Ser Gly Gly Asp 
        115                 120                 125             


Asn Asn Asn Lys Phe Phe Gly Phe Ser Thr Pro Trp Gly Tyr Phe Asp 
    130                 135                 140                 


Tyr Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu 
145                 150                 155                 160 


Ile Asn Asn Asn Trp Gly Ile Arg Pro Lys Ala Met Arg Phe Arg Leu 
                165                 170                 175     


Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Phe Asn Thr Thr 
            180                 185                 190         


Ile Gly Asn Asn Leu Thr Ser Thr Val Gln Val Phe Ala Asp Lys Asp 
        195                 200                 205             


Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala Thr Glu Gly Thr Phe Pro 
    210                 215                 220                 


Pro Phe Pro Ala Asp Ile Tyr Thr Ile Pro Gln Tyr Gly Tyr Cys Thr 
225                 230                 235                 240 


Leu Asn Tyr Asn Asn Glu Ala Val Asp Arg Ser Ala Phe Tyr Cys Leu 
                245                 250                 255     


Asp Tyr Phe Pro Ser Asp Met Leu Arg Thr Gly Asn Asn Phe Glu Phe 
            260                 265                 270         


Thr Tyr Thr Phe Glu Asp Val Pro Phe His Ser Met Phe Ala His Asn 
        275                 280                 285             


Gln Thr Leu Asp Arg Leu Met Asn Pro Leu Val Asp Gln Tyr Leu Trp 
    290                 295                 300                 


Ala Phe Ser Ser Val Ser Gln Ala Gly Ser Ser Gly Arg Ala Leu His 
305                 310                 315                 320 


Tyr Ser Arg Ala Thr Lys Thr Asn Met Ala Ala Gln Tyr Arg Asn Trp 
                325                 330                 335     


Leu Pro Gly Pro Phe Phe Arg Asp Gln Gln Ile Phe Thr Gly Ala Ser 
            340                 345                 350         


Asn Ile Thr Lys Asn Asn Val Phe Ser Val Trp Glu Lys Gly Lys Gln 
        355                 360                 365             


Trp Glu Leu Asp Asn Arg Thr Asn Leu Met Gln Pro Gly Pro Ala Ala 
    370                 375                 380                 


Ala Thr Thr Phe Ser Gly Glu Pro Asp Arg Gln Ala Met Gln Asn Thr 
385                 390                 395                 400 


Leu Ala Phe Ser Arg Thr Val Tyr Asp Gln Thr Thr Ala Thr Thr Asp 
                405                 410                 415     


Arg Asn Gln Ile Leu Ile Thr Asn Glu Asp Glu Ile Arg Pro Thr Asn 
            420                 425                 430         


Ser Val Gly Ile Asp Ala Trp Gly Ala Val Pro Thr Asn Asn Gln Ser 
        435                 440                 445             


Ile Val Thr Pro Gly Thr Arg Ala Ala Val Asn Asn Gln Gly Ala Leu 
    450                 455                 460                 


Pro Gly Met Val Trp Gln Asn Arg Asp Ile Tyr Pro Thr Gly Thr His 
465                 470                 475                 480 


Leu Ala Lys Ile Pro Asp Thr Asp Asn His Phe His Pro Ser Pro Leu 
                485                 490                 495     


Ile Gly Arg Phe Gly Cys Lys His Pro Pro Pro Gln Ile Phe Ile Lys 
            500                 505                 510         


Asn Thr Pro Val Pro Ala Asn Pro Ser Glu Thr Phe Gln Thr Ala Lys 
        515                 520                 525             


Val Ala Ser Phe Ile Asn Gln Tyr Ser Thr Gly Gln Cys Thr Val Glu 
    530                 535                 540                 


Ile Phe Trp Glu Leu Lys Lys Glu Thr Ser Lys Arg Trp Asn Pro Glu 
545                 550                 555                 560 


Ile Gln Phe Thr Ser Asn Phe Gly Asn Ala Ala Asp Ile Gln Phe Ala 
                565                 570                 575     


Val Ser Asp Thr Gly Ser Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg 
            580                 585                 590         


Tyr Leu Thr Lys Pro Leu 
        595             


<210> 5190
<211> 4694
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5190
tggccagttt ccaagacagg ctcgctcgct cactcgggcc ggggccccaa aggggcccct       60

agcgaccgct tcgcggtcgc ggcccgagtg agcgagcgag cctgtcttgg aaactggcca      120

gcactccggt gaggtaatgc cgtcacgtgg tcgggaatgg gaacgggaaa tctcgcgaga      180

acgtaaacaa atataagacg gcgccacacg gcgctgcgtc atacgcgcgc gcgcaccggc      240

gagatgaggt cgtactacga ggtcatcgtt cagctgccca acgacgtcga gagtcaggta      300

cctggaatct ccgattcgtt cgtcaactgg attacgtcgc gagaatggac gttgcctgag      360

gacgccgatt gggatttgga ccaggtcgat caagttcaac tgacgctcgg cgacaaaatc      420

caacgggaga ttcgaactca ttgggggacg atggccaaag aaccggactt tcactatttt      480

atccaactgg aacaaggtga ggtgttcttt catttacacg tcctgctgga aacgtgttcc      540

gtaaagccga tggtactcgg aagatatatc cgacatattc aacaaaaaat tgtgagtaaa      600

gtctactgcg ccacgagcct acgatggaag gatggatgcg tggtgaccaa gaccaaaaat      660

ttcgggggcg cgaacaaggt ccgggccgag tcgtatattc ccgcctacct gatcccgaaa      720

cagcaaccgg aagtgcagtg ggcgtggact aacgtgcccg agtatataaa agcgtgcttg      780

caccgagaac tgcgtgccag tctcgcgcga cttcacttcg aggaggcggg cgtctcgcaa      840

tccaaggaaa atctcgcgag aactgcagac ggcgctcccg tgatgccgac ccgcgtcagc      900

aaacgctaca tggagctcgt ggattggctc gtggagaagg ggatcaccac cgagaaggaa      960

tggctgctgg aaaacagaga aagctttcgg agctttcagg cctcgagcaa ctcggcgcgt     1020

cagatcaaga cggccctgca aggcgccatt caggagatgc ttctgaccaa gacggcggag     1080

gactacctcg tcggaaagga tcccgtctcg gacgacgaca tccgtcagaa ccgcatctac     1140

aagattctgg aactgaacca ctacgaccca gcgtacgtgg ggagtatttt ggtcgggtgg     1200

tgccagaaga aatggggcaa gcgaaacacg ctgtggctgt tcggacatgc gaccaccggc     1260

aagaccaaca tcgcggaggc tattgcccat gctgtgccgt tctatggatg cgttaactgg     1320

accaacgaga actttccgtt caacgactgc gtcgaaaaaa tgattatctg gtgggaggag     1380

ggcaaaatga ccgccaaagt ggtggaaaca gccaaggcga ttctgggagg atctcgggtg     1440

agagtggacc aaaaatgcaa agcttcggtt ccgatcgaac cgacgccggt cattattacc     1500

agtaacacca acatgtgtta tgtcatcgac gggaacacga ccacgttcga gcataagcag     1560

ccgttggagg acaggatgtt taagctcgaa ttgctgactc ggttgcctga tgactttggt     1620

aaggtgacca aacaggaggt gcgtcaattc ttcaggtggt ctcaggatca cctgacccct     1680

gtgatcccag aattcctagt gcggaaggcg gagtctcgca aaagacccgc cccttccggg     1740

gaaggctata taagcccgac aaagcggccc gcgctcgcag agcagcagca ggcgtcggag     1800

agcgcggacc cggttcccac caggtatcgt atcaaatgct cgaaacattg cggtatggat     1860

aaaatgttgt ttccttgcca aatttgtgaa tcgatgaaca gagatattaa tatttgtgct     1920

attcataaaa cgaccgactg taaagagtgt ttccccgact acggggataa agatgatgta     1980

gaactacccc cctgtacaga acacaacgtg tctcgttgtt atcaatgtca ttcgggcgaa     2040

ttgtatcgcg tgacttcgga ctctgacgag aaacctgccc ccgagagtga tgaaggcacc     2100

gagccatcct atgctccctg cacgattcac cacctgatgg gcaagagtca cgggttagtc     2160

acttgcgcgg cgtgtcggtt gaaaaatagt acgttgcatg atgacttgga tgacggtgat     2220

ctcgaacaat aaatgattga aatgtagcca tgtctctcat ttctgatgcg attccagatt     2280

ggttggagcg gttggtcaaa aagggagtga atgctgcagc tgatttctac catttggaaa     2340

gcggtcctcc tcgtcctaag gcaaatcagc aaactcaaga atctcttgaa aaggacgatt     2400

cgagaggtct cgtgttccca ggctacaatt atctaggccc tttcaacggt ctagataaag     2460

gagaacccgt caacgaggca gacgctgccg ccttagaaca cgacaaggct tacgacctcg     2520

aaatcaagga cgggcacaac ccgtactttg agtacaacga ggccgacaga cgtttccagg     2580

aacgtctcaa agacgatacc tcctttggag gcaatttagg taaagccatc ttccaggcca     2640

aaaagagggt tctcgaaccc tttggtctgg tggaagactc aaagacggct ccgaccggag     2700

acaagcggaa aggcgaagac gaacctcgtt tgcccgacac ttcttcacag actcccaaga     2760

aaaacaagaa gcctcgcaag gaaagacctt ccggcggggc agaagatccg ggcgaaggca     2820

cctcttccaa cgctggagca gcagcacccg cctctagtgt gggatcatct atcatggctg     2880

aaggaggtgg cggcccagtg ggcgatgcag gccagggtgc cgatggagtg ggcaattcct     2940

ccggaaattg gcattgcgat tcccaatggc tggaaaacgg agtcgtcact cgaaccaccc     3000

gaacctgggt cttgcccagc tacaacaacc acctgtacaa acgaatccaa ggacccagcg     3060

gaggcgacaa caacaacaaa ttctttggat tcagcacccc ctggggatac tttgactaca     3120

atcgattcca ctgccacttt tccccgcgag actggcaacg actcatcaac aacaactggg     3180

gcatccgtcc caaagcgatg cgctttagac tctttaacat ccaggttaaa gaggtcacgg     3240

tccaagactt caacaccacc atcggcaaca acctcaccag tacggtccag gtctttgcgg     3300

acaaggacta ccaactgccg tacgtcctcg gatcggctac cgaaggcacc ttcccgccgt     3360

tcccagcgga tatctacacg atcccgcagt acgggtactg cacgctaaac tacaacaacg     3420

aggcggtgga tcgttcggcc ttctactgtc tggactactt tccctcagac atgctgcgga     3480

caggaaataa ctttgagttt acttacacct tcgaggacgt tcctttccat agcatgtttg     3540

cccacaacca gacgctagac cggctgatga atcccctcgt ggatcagtac ctctgggctt     3600

tcagctccgt cagccaagca ggctcatctg gacgagctct tcattactcg cgggcgacta     3660

aaaccaacat ggcggctcaa tataggaact ggttacctgg gcctttcttc cgtgatcagc     3720

aaatctttac gggcgctagc aacatcacta aaaataacgt ctttagcgtt tgggaaaaag     3780

gcaagcaatg ggaactcgac aatcggacca acctaatgca gcccggtcct gcggcagcga     3840

ccacctttag cggagaacct gaccgtcaag ccatgcaaaa cacgctggct tttagcagga     3900

ccgtctacga tcaaacgacc gccacgaccg atcgtaacca gatactcatc accaacgaag     3960

acgaaatcag acccaccaac tcggtcggta tcgacgcgtg gggagcagtt cccaccaaca     4020

accagtcgat cgtgaccccc ggcactcgcg cggccgtcaa caatcaaggg gcgcttcccg     4080

ggatggtgtg gcaaaacaga gacatttacc ctacagggac ccatttggcc aaaattcccg     4140

acactgacaa tcacttccat ccgtccccgc ttattgggcg gtttggctgc aagcatcccc     4200

ctccccagat tttcattaaa aacacacccg tccctgccaa cccttcggaa acgttccaga     4260

cggccaaagt ggcctccttc atcaaccagt actcgaccgg acagtgcacc gtcgaaatct     4320

tttgggaact caagaaggaa acctccaagc gctggaaccc cgaaatccag ttcacctcca     4380

actttggcaa cgcggccgac atccagtttg ccgtctccga cacgggatcc tattccgaac     4440

ctcgtcccat cggtacccgt taccttacca aacctctgta aattaaaccc ttcaataaac     4500

cgtttatgcg taactgtatt tccgtctcct gtcgttattc agtcacatga tgcggcatta     4560

cctcaccgga gtgctggcca gtttccaaga caggctcgct cgctcactcg ggccggggcc     4620

ccaaaggggc ccctagcgac cgcttcgcgg tcgcggcccg agtgagcgag cgagcctgtc     4680

ttggaaactg gcca                                                       4694


<210> 5191
<211> 2211
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5191
atggctgctg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggtga caacccctac ctcaagtaca accacgccga cgcggagttc      300

cagcagcggc ttcagggcga cacatcgttt gggggcaacc tcggcagagc agtcttccag      360

gccaaaaaga gggttcttga acctcttggt ctggttgagc aagcgggtga gacggctcct      420

ggaaagaaga gaccgttgat tgaatccccc cagcagcccg actcctccac gggtatcggc      480

aaaaaaggca agcagccggc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggtgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgcacctg ggccttgccc acctacaata accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg acttcaacag attccactgc cacttttcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaaactctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acaaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc agactatcag ctcccgtacg tgctcgggtc ggctcacgag     1080

ggctgcctcc cgccgttccc agcagacgtc ttcatggtgc cacagtatgg atacctcacc     1140

ctgaacaacg ggagtcaggc agtaggacgc tcttcatttt actgcctgga gtactttcct     1200

tctcagatgc tgcgtaccgg aaacaacttt accttcagct acacttttga ggacgttcct     1260

ttccacagca gctacgctca cagccagagt ctggaccgtc tcatgaatcc tctcatcgac     1320

cagtacctgt attacctgaa cagaactcag aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgggggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaac     1500

tttacctgga ctggtgcttc aaaatataac cttaatgggc gtgaatctat aatcaaccct     1560

ggcactgcta tggcctcaca caaagacgac aaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaggagag cgccggagct tcaaacactg cattggacaa tgtcatgatc     1680

acagacgaag aggaaatcaa agccactaac cccgtggcca ccgaaagatt tgggactgtg     1740

gcagtcaatc tccagagcag cagcacagac cctgcgaccg gagatgtgca tgttatggga     1800

gccttacctg gaatggtgtg gcaagacaga gacgtatacc tgcagggtcc catttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccaat actccacagg acaagtgagt     2040

gtggaaattg aatgggagct gcagaaagaa aacagcaagc gctggaatcc cgaagtgcag     2100

tacacatcca attatgcaaa atctgccaac gttgatttta ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtcccctgta a              2211


<210> 5192
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5192
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Gln Arg Leu Gln Gly Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Gln Ala Gly Glu Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Leu Ile Glu Ser Pro Gln Gln Pro Asp Ser Ser Thr Gly Ile Gly 
145                 150                 155                 160 


Lys Lys Gly Lys Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Asp Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5193
<211> 2211
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5193
atggcttccg atggttatct tccagattgg ctcgaggaca acctctctga gggcatccgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggatgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca gagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaaga gggttctcga accttttggt ctggttgagg aaggtgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcattggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgaacatg ggccttgccc acctataaca accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc catttctcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaaactctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acaaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag cttccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcagtacgg ctacctaacg     1140

ctcaacaatg gcagccaggc agtgggacgg tcatcctttt actgcctgga atatttccca     1200

tcgcagatgc tgagaacggg caataacttt accttcagct acaccttcga ggacgtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

cagtacctgt attacctgaa cagaactcag aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgggggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt accggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaac     1500

tttacctgga ctggtgcttc aaaatataac cttaatgggc gtgaatctat aatcaaccct     1560

ggcactgcta tggcctcaca caaagacgac aaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaggagag cgccggagct tcaaacactg cattggacaa tgtcatgatc     1680

acagacgaag aggaaatcaa agccactaac cccgtggcca ccgaaagatt tgggactgtg     1740

gcagtcaatc tccagagcag cagcacagac cctgcgaccg gagatgtgca tgttatggga     1800

gccttacctg gaatggtgtg gcaagacaga gacgtatacc tgcagggtcc catttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactt     1920

aagcacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggca     1980

gagttttcgg ctacaaagtt tgcttcattc atcacccagt attctactgg ccaagtcagc     2040

gtggagattg aatgggagct gcagaaagaa aacagcaaac gctggaatcc cgaagtgcag     2100

tatacatcta actatgcaaa atctgccaac gttgatttca ctgtggacaa caatggactt     2160

tatactgagc ctcgtcccat tggcacccgt tacctcaccc gtcccctgta a              2211


<210> 5194
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5194
Met Ala Ser Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Arg Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5195
<211> 2211
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5195
atggctgctg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggtga caacccctac ctcaagtaca accacgccga cgcggagttc      300

cagcagcggc ttcagggcga cacatcgttt gggggcaacc tcggcagagc agtcttccag      360

gccaaaaaga gggttcttga acctcttggt ctggttgagc aagcgggtga gacggctcct      420

ggaaagaaga gaccgttgat tgaatccccc cagcagcccg actcctccac gggtatcggc      480

aaaaaaggca agcagccggc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggtgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgcacctg ggccttgccc acctacaata accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg acttcaacag attccactgc cacttttcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaaactctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acaaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc agactatcag ctcccgtacg tgctcgggtc ggctcacgag     1080

ggctgcctcc cgccgttccc agcagacgtc ttcatggtgc cacagtatgg atacctcacc     1140

ctgaacaacg ggagtcaggc agtaggacgc tcttcatttt actgcctgga gtactttcct     1200

tctcagatgc tgcgtaccgg aaacaacttt accttcagct acacttttga ggacgttcct     1260

ttccacagca gctacgctca cagccagagt ctggaccgtc tcatgaatcc tctcatcgac     1320

cagtacctgt attacctgaa cagaactcag aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgggggtc tccaactggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaac     1500

tttacctgga ctggtgcttc aaaatataac cttaatgggc gtgaatctat aatcaaccct     1560

ggcactgcta tggcctcaca caaagacgac aaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaggagag cgccggagct tcaaacactg cattggacaa tgtcatgatc     1680

acagacgaag aggaaatcaa agccactaac cccgtggcca ctgaaagatt tgggactgtg     1740

gcagtcaatc tccagagcag cagcacagac cctgcgaccg gagatgtgca tgccatggga     1800

gccttacctg gaatggtgtg gcaagacaga gacgtatacc tgcagggtcc tatttgggcc     1860

aaaattcctc acacggatgg acactttcac ccgtctcctc tcatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccagt attccacagg acaagtgagc     2040

gtggagattg aatgggagct gcagaaagaa aacagcaaac gctggaatcc cgaagtgcag     2100

tatacatcta actatgcaaa atctgccaac gttgatttca ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtcccctgta a              2211


<210> 5196
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5196
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Gln Arg Leu Gln Gly Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Gln Ala Gly Glu Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Leu Ile Glu Ser Pro Gln Gln Pro Asp Ser Ser Thr Gly Ile Gly 
145                 150                 155                 160 


Lys Lys Gly Lys Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Asp Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Thr Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5197
<211> 2211
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5197
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggatgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcaatcgcca caagagccag actcctcctc gggcatcggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgaacatg ggccttgccc acctataaca accacctcta caagcaaatc      780

tccagtgctt cgacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg actttaacag attccactgc cacttttcac cacgtgactg gcagcgactc      900

atcaacaaca actggggatt ccggcccaag agactcagct tcaagctctt caacatccag      960

gtcaaggagg tcacgacgaa tgatggcgtc acaaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag cttccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcaatacgg ctacctgacg     1140

ctcaacaatg gcagccaagc cgtgggacgt tcatcctttt actgcctgga atatttccct     1200

tctcagatgc tgagaacggg caacaacttt accttcagct acacctttga ggaagtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgat     1320

caatacctgt attacctgaa cagaactcaa aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgtgggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaat     1500

tttacctgga ctggtgcttc aaaatataac ctcaatgggc gtgaatccat catcaaccct     1560

ggcactgcta tggcctcaca taaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaagagag cgccggagct tcaaacactg cattggacaa tgtcatgatt     1680

acagacgaag aggaaattaa agccactaac cctgtggcca ccgaaagatt tgggaccgtg     1740

gcagtcaatt tccagagcag cagcacagac cctgcgaccg gagatgtgca tgctatggga     1800

gcattacctg gcatggtgtg gcaagataga gacgtgtacc tgcagggtcc catttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccaat actccacagg acaagtgagc     2040

gtggagattg aatgggagct gcagaaagaa aacagcaaac gctggaatcc cgaagtgcag     2100

tatacatcta actatgcaaa atctgccaac attgatttca ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtccccagta a              2211


<210> 5198
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5198
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Ile Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Gln 
                725                 730                 735     


<210> 5199
<211> 2211
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5199
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggatgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac cttcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga gggttctcga acctctcggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcattggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgcacctg ggccttgccc acctacaata accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg acttcaacag attccactgc cacttttcac cacgtgactg gcaaagactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaagctctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acgaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag ttgccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcagtacgg ctacctaacg     1140

ctcaacaatg gcagccaggc agtgggacgg tcatcctttt actgcctgga atatttccca     1200

tcgcagatgc tgagaacggg caacaacttt accttcagct acacctttga ggaagtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

cagtacctgt attacctgaa cagaactcaa aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgtgggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt accggcagca gtgcgtttct aaaacaaaaa cagacaacaa caacagcaac     1500

tttacctgga ctggtgcttc aaaatataac cttaatgggc gtgaatctat aatcaaccct     1560

ggcactgcta tggcctcaca caaagacgac aaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaggagag cgccggagct tcaaacactg cattggacaa tgtcatgatc     1680

acagacgaag aggaaatcaa agccactaac cccgtggcca ccgaaagatt tgggactgtg     1740

gcagtcaatc tccagagcag cagcacagac cctgcgaccg gagatgtgca tgttatggga     1800

gccttacctg gaatggtgtg gcaagacaga gacgtatacc tgcagggtcc tatttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccaat actccacagg acaagtgagc     2040

gtggagattg aatgggagct gcagaaagaa aacagcaagc gctggaatcc cgaagtgcag     2100

tacacatcca attatgcaaa atctgccaac gttgatttca ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtcccctgta a              2211


<210> 5200
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5200
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Cys Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5201
<211> 2211
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5201
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gaatggtggg acttgaaacc tggagccccg aaacccaaag tcaaccagca aaagcaggac      120

aacgctcggg gtcttgtgct tccgggttac aaatacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac cttcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc ttggacgagc agtcttccag      360

gccaagaaga gggttctcga accttttggt ctggttgagg aaggtgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcattggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgcacctg ggccttgccc acctacaata accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg acttcaacag attccactgc cacttttcac cacgtgactg gcaaagactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaagctctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acgaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag ttgccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcaatacgg ctacctgacg     1140

ctcaacaatg gcagccaggc agtgggacgg tcatcctttt actgcctgga atatttccca     1200

tcgcagatgc tgagaacggg caataacttt accttcagct acacttttga ggacgttcct     1260

ttccacagca gctacgctca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

cagtacctgt attacctgaa cagaactcag aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgtgggtc tccaactggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaac     1500

tttacctgga ctggtgcttc aaaatataac cttaatgggc gtgaatctat aatcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaggagag cgccggagct tcaaacactg cattggacaa tgtcatgatc     1680

acagacgaag aggaaatcaa agccactaac cccgtggcca ctgaaagatt tgggactgtg     1740

gcagtcaatc tccagagcag cagcacagac cctgcgaccg gagatgtgca tgccatggga     1800

gccttacctg gaatggtgtg gcaagacaga gacgtatacc tgcagggtcc tatttgggcc     1860

aaaattcctc acacggatgg acactttcac ccgtctcctc tcatgggcgg ctttggactt     1920

aagcacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggca     1980

gagttttcgg ctacaaagtt tgcttcattc atcacccagt attccacagg acaagtgagc     2040

gtggagattg aatgggagct gcagaaagaa aacagcaaac gctggaatcc cgaagtgcag     2100

tatacatcta actatgcaaa atctgccaac gttgatttca ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtcccctgta a              2211


<210> 5202
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5202
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Val Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Thr Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5203
<211> 2208
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (955)..(955)
<223> a, c, t or g

<220>
<221> modified_base
<222> (971)..(972)
<223> a, c, t or g

<220>
<221> modified_base
<222> (981)..(981)
<223> a, c, t or g

<220>
<221> modified_base
<222> (986)..(986)
<223> a, c, t or g

<220>
<221> modified_base
<222> (1235)..(1235)
<223> a, c, t or g

<220>
<221> modified_base
<222> (1694)..(1696)
<223> a, c, t or g

<220>
<221> modified_base
<222> (1698)..(1698)
<223> a, c, t or g

<220>
<221> modified_base
<222> (1763)..(1765)
<223> a, c, t or g

<220>
<221> modified_base
<222> (1778)..(1778)
<223> a, c, t or g

<220>
<221> modified_base
<222> (2204)..(2204)
<223> a, c, t or g

<400> 5203
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gaatggtggg acttgaaacc tggagccccg aaacccaaag tcaaccagca aaagcaggac      120

aacgctcggg gtcttgtgct tccgggttac aaatacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac cttcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc ttggacgagc agtcttccag      360

gccaagaaga gggttctcga accttttggt ctggttgagg aaggtgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcattggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgaacatg ggccttgccc acctataaca accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc cacttttcac cacgtgactg gcagcgactc      900

atcaataaca attggggatt ccggcccaag agactcaact tcaaactctt caacntccaa      960

gtcaaggagg nnacgacgaa ngatgncgtc acaaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag cttccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcaatacgg ctacctgacg     1140

ctcaacaatg gcagccaggc agtgggacgg tcatcctttt actgcctgga atatttccca     1200

tcgcagatgc tgagaacggg caataacttt acctncagct acacttttga ggacgttcct     1260

ttccacagca gctacgctca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

cagtacctgt attacctgaa cagaactcag aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgtgggtc tccaactggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaac     1500

tttacctgga ctggtgcttc aaaatataac cttaatgggc gtgaatctat aatcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaggagag cgccggagct tcaaacactg cattggacaa tgtcatgatc     1680

acagacgaag agannncnaa gccactaacc ccgtggccac tgaaagattt gggactgtgg     1740

cagtcaatct ccaagcagca cannnaccct gcgaccgnag atgtgcatgc catgggagcc     1800

ttacctggaa tggtgtggca agacagagac gtatacctgc agggtcctat ttgggccaaa     1860

attcctcaca cggatggaca ctttcacccg tctcctctca tgggcggctt tggacttaag     1920

cacccgcctc ctcagatcct catcaaaaac acgcctgttc ctgcgaatcc tccggcagag     1980

ttttcggcta caaagtttgc ttcattcatc acccagtatt ccacaggaca agtgagcgtg     2040

gagattgaat gggagctgca gaaagaaaac agcaaacgct ggaatcccga agtgcagtat     2100

acatctaact atgcaaaatc tgccaacgtt gatttcactg tggacaacaa tggactttat     2160

actgagcctc gccccattgg cacccgttac ctcacccgtc cccngtaa                  2208


<210> 5204
<211> 723
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5204
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Val Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Gln Val 
305                 310                 315                 320 


Lys Glu Thr Thr Asp Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr 
                325                 330                 335     


Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly 
            340                 345                 350         


Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met 
        355                 360                 365             


Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ala Val 
    370                 375                 380                 


Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu 
385                 390                 395                 400 


Arg Thr Gly Asn Asn Phe Thr Ser Tyr Thr Phe Glu Asp Val Pro Phe 
                405                 410                 415     


His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr Gln Asn Gln Ser 
        435                 440                 445             


Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser Arg Gly Ser Pro Thr 
    450                 455                 460                 


Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg 
465                 470                 475                 480 


Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn Asn Asn Ser Asn Phe 
                485                 490                 495     


Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn Gly Arg Glu Ser Ile 
            500                 505                 510         


Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys Asp Asp Glu Asp Lys 
        515                 520                 525             


Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly Lys Glu Ser Ala Gly 
    530                 535                 540                 


Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile Thr Asp Glu Glu Ala 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Arg Phe Gly Thr Val Ala Val Asn Leu 
                565                 570                 575     


Gln Ser Ser Pro Ala Thr Asp Val His Ala Met Gly Ala Leu Pro Gly 
            580                 585                 590         


Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala 
        595                 600                 605             


Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly 
    610                 615                 620                 


Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr 
625                 630                 635                 640 


Pro Val Pro Ala Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala 
                645                 650                 655     


Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu 
            660                 665                 670         


Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln 
        675                 680                 685             


Tyr Thr Ser Asn Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp 
    690                 695                 700                 


Asn Asn Gly Leu Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu 
705                 710                 715                 720 


Thr Arg Pro 
            


<210> 5205
<211> 2208
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5205
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctatgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggtc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaagttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggtaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacagacgct ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca agtgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga agttcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 5206
<211> 735
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5206
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Lys Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asp Ala Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Ser Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 5207
<211> 2208
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5207
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctatgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcaaac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaagttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcgggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggtaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacagacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca agtgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac gaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga agttcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

acagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 5208
<211> 735
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5208
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asn Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Lys Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Arg Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asp Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Ser Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 5209
<211> 2211
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5209
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcatcggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgaacatg ggccttgccc acctataaca accacctcta caagcaaatc      780

tccagtgctt cgacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg actttaacag attccactgc cacttttcac cacgtgactg gcagcgactc      900

atcaacaata actggggatt ccggcccaag agactcagct tcaagctctt caacatccag      960

gtcaaggagg tcacgacgaa tgatggcgtc acaaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag cttccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcaatacgg ctacctgacg     1140

ctcaacaatg gcagccaagc cgtgggacgt tcatcctttt actgcctgga atatttccct     1200

tctcagatgc tgagaacggg caacaacttt accttcagct acacctttga ggaagtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgat     1320

caatacctgt attacctgaa cagaactcaa aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgtgggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaat     1500

tttacctgga ctggtgcttc aaaatataac ctcaatgggc gtgaatccat catcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaagagag cgccggagct tcaaacactg cattggacaa tgtcatgatt     1680

acggacgaag aggaaattaa agccactaac cctgtggcca ccgaaagatt tgggaccgtg     1740

gcagtcaatt tccagagcag cagcacagac cctgcgaccg gagatgtgca tgctatggga     1800

gcattacctg gcatggtgtg gcaagataga gacgtgtacc tgcagggtcc catttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcactcaat actccacagg acaagtgagc     2040

gtggaaattg aatgggagct gcagaaagaa aacagcaaac gctggaatcc cgaagtgcag     2100

tatacatcta actatgcaaa atctgccaac gttgatttca ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtcccctgta a              2211


<210> 5210
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5210
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5211
<211> 735
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5211
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Lys Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asp Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asn Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Ser Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Gln 
                725                 730                 735 


<210> 5212
<211> 2208
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5212
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctatgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggaacgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaagttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggtaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacagacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cggaaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca agtgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga agttcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atcagtaa                  2208


<210> 5213
<211> 2208
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5213
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctatgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg atccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaagttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtatgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggtaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacagacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca agtgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga agttcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 5214
<211> 735
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5214
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Lys Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asp Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Ser Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 5215
<211> 2172
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5215
atgtcttttg ttgatcaccc tccagattgg ttggaagaag ttggtgaagg tcttcgcgag       60

tttttgggcc ttgaagcggg cccaccgaaa ccaaaaccca atcagcagca tcaagatcaa      120

gcccgtggtc ttgtgctgcc tggttataac tatctcggac ccggaaacgg tctcgatcga      180

ggagagcctg tcaacagggc agacgaggtc gcgcgagagc acgacatctc gtacaacgag      240

cagcttgagg cgggagacaa cccctacctc aagtacaacc acgcggacgc cgagtttcag      300

gagaagctcg ccgacgacac atccttcggg ggaaacctcg gaaaggcagt ctttcaggcc      360

aagaaaaggg ttctcgaacc ttttggcctg gttgaagagg gtgctaagac ggcccctacc      420

ggaaagcgga tagacgacca ctttccaaaa agaaagaagg ctcggaccga agaggactcc      480

aagccttcca cctcgtcaga cgccgaagct ggacccagcg gatcccagca gctgcaaatc      540

ccagcccaac cagcctcaag tttgggagct gatacaatgt ctgcgggagg tggcggccca      600

ttgggcgaca ataaccaagg tgccgatgga gtgggcaatg cctcgggaga ttggcattgc      660

gattccacgt ggatggggga cagagtcgtc accaagtcca cccgaacctg ggtgctgccc      720

agctacaaca accaccagta ccgagagatc aaaagcggct ccgtcgacgg aagcaacgcc      780

aacgcctact ttggatacag caccccctgg gggtactttg actttaaccg cttccacagc      840

cactggagcc cccgagactg gcaaagactc atcaacaact actggggctt cagaccccgg      900

tccctcagag tcaaaatctt caacattcaa gtcaaagagg tcacggtgca ggactccacc      960

accaccatcg ccaacaacct cacctccacc gtccaagtgt ttacggacga cgactaccag     1020

ctgccctacg tcgtcggcaa cgggaccgag ggatgcctgc cggccttccc tccgcaggtc     1080

tttacgctgc cgcagtacgg ttacgcgacg ctgaaccgcg acaacacaga aaatcccacc     1140

gagaggagca gcttcttctg cctagagtac tttcccagca agatgctgag aacgggcaac     1200

aactttgagt ttacctacaa ctttgaggag gtgcccttcc actccagctt cgctcccagt     1260

cagaacctgt tcaagctggc caacccgctg gtggaccagt acttgtaccg cttcgtgagc     1320

acaaataaca ctggcggagt ccagttcaac aagaacctgg ccgggagata cgccaacacc     1380

tacaaaaact ggttcccggg gcccatgggc cgaacccagg gctggaacct gggctccggg     1440

gtcaaccgcg ccagtgtcag cgccttcgcc acgaccaata ggatggagct cgagggcgcg     1500

agttaccagg tgcccccgca gccgaacggc atgaccaaca acctccaggg cagcaacacc     1560

tatgccctgg agaacactat gatcttcaac agccagccgg cgaacccggg caccaccgcc     1620

acgtacctcg agggcaacat gctcatcacc agcgagagcg agacgcagcc ggtgaaccgc     1680

gtggcgtaca acgtcggcgg gcagatggcc accaacaacc agagctccac cactgccccc     1740

gcgaccggca cgtacaacct ccaggaaatc gtgcccggca gcgtgtggat ggagagggac     1800

gtgtacctcc aaggacccat ctgggccaag atcccagaga cgggggcgca ctttcacccc     1860

tctccggcca tgggcggatt cggactcaaa cacccaccgc ccatgatgct catcaagaac     1920

acgcctgtgc ccggaaatat caccagcttc tcggacgtgc ccgtcagcag cttcatcacc     1980

cagtacagca ccgggcaggt caccgtggag atggagtggg agctcaagaa ggaaaactcc     2040

aagaggtgga acccagagat ccagtacaca aacaactaca acgaccccca gtttgtggac     2100

tttgccccgg acagcaccgg ggaatacaga accaccagac ctatcggaac ccgatacctt     2160

acccgacccc tt                                                         2172


<210> 5216
<211> 2214
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5216
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagaaag gccaacagcc cgccagaaaa agactcaatt ttggtcagac tggcgactca      540

gagtcagttc cagaccctca acctctcgga gaacctccag cagcgccctc tggtgtggga      600

cctaatacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacatcggg aggagccacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tttcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggag taccagctgc cgtacgttct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtgttca tgattcccca gtacggctac     1140

ctaacactca acaacggtag tcaggccgtg ggacgctcct ccttctactg cctggaatac     1200

tttccttcgc agatgctgag aaccggcaac aacttccagt ttacttacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcccacagc cagagcttgg accggctgat gaatcctctg     1320

attgaccagt acctgtacta cttgtctcgg actcaaacaa caggaggcac ggcaaatacg     1380

cagactctgg gcttcagcca aggtgggcct aatacaatgg ccaatcaggc aaagaactgg     1440

ctgccaggac cctgttaccg ccaacaacgc gtctcaacga caaccgggca aaacaacaat     1500

agcaactttg cctggactgc tgggaccaaa taccatctga atggaagaaa ttcattggct     1560

aatcctggca tcgctatggc aacacacaaa gacgacgagg agcgtttttt tcccagtaac     1620

gggatcctga tttttggcaa acaaaatgct gccagagaca atgcggatta cagcgatgtc     1680

atgctcacca gcgaggaaga aatcaaaacc actaaccctg tggctacaga ggaatacggt     1740

atcgtggcag ataacttgcc tgagcggacg gcgatgagtc ttccgggaac tgtcaacagc     1800

cagggggcct tacccggtat ggtctggcag aaccgggacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccacccgt ctccgctgat gggcggcttt     1920

ggcctgaaac atcctccgcc tcagatcctg atcaagaaca cgcctgtacc tgcggatcct     1980

ccgaccacct tcaaccagtc aaagctgaac tctttcatca cgcaatacag caccggacag     2040

gtcagcgtgg aaattgaatg ggagctgcag aaggaaaaca gcaagcgctg gaaccccgag     2100

atccagtaca cctccaacta ctacaaatct acaagtgtgg actttgctgt taatacagaa     2160

ggcgtgtact ctgaaccccg ccccattggc acccgttacc tcacccgtaa tctg           2214


<210> 5217
<211> 738
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5217
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly 
    450                 455                 460                 


Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile 
    530                 535                 540                 


Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Pro Glu Arg Thr Ala Met 
            580                 585                 590         


Ser Leu Pro Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5218
<211> 2214
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5218
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagaaag gccaacagcc cgccagaaaa agactcaatt ttggtcagac tggcgactca      540

gagtcagttc cagaccctca acctctcgga gaacctccag cagcgccctc tggtgtggga      600

cctaatacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacatcggg aggagccacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tttcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggag taccagctgc cgtacgttct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtgttca tgattcccca gtacggctac     1140

ctaacactca acaacggtag tcaggccgtg ggacgctcct ccttctactg cctggaatac     1200

tttccttcgc agatgctgag aaccggcaac aacttccagt ttacttacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcccacagc cagagcttgg accggctgat gaatcctctg     1320

attgaccagt acctgtacta cttgtctcgg actcaaacaa caggaggcac ggcaaatacg     1380

cagactctgg gcttcagcca aggtgggcct aatacaatgg ccaatcaggc aaagaactgg     1440

ctgccaggac cctgttaccg ccaacaacgc gtctcaacga caaccgggca aaacaacaat     1500

agcaactttg cctggactgc tgggaccaaa taccatctga atggaagaaa ttcattggct     1560

aatcctggca tcgctatggc aacacacaaa gacgacgagg agcgtttttt tcccagtaac     1620

gggatcctga tttttggcaa acaaaatgct gccagagaca atgcggatta cagcgatgtc     1680

atgctcacca gcgaggaaga aatcaaaacc actaaccctg tggctacaga ggaatacggt     1740

atcgtggcag ataacttgag ttttagtcgt gcggttcttt gtgatggaac tgtcaacagc     1800

cagggggcct tacccggtat ggtctggcag aaccgggacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccacccgt ctccgctgat gggcggcttt     1920

ggcctgaaac atcctccgcc tcagatcctg atcaagaaca cgcctgtacc tgcggatcct     1980

ccgaccacct tcaaccagtc aaagctgaac tctttcatca cgcaatacag caccggacag     2040

gtcagcgtgg aaattgaatg ggagctgcag aaggaaaaca gcaagcgctg gaaccccgag     2100

atccagtaca cctccaacta ctacaaatct acaagtgtgg actttgctgt taatacagaa     2160

ggcgtgtact ctgaaccccg ccccattggc acccgttacc tcacccgtaa tctg           2214


<210> 5219
<211> 738
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5219
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly 
    450                 455                 460                 


Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile 
    530                 535                 540                 


Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Ser Phe Ser Arg Ala Val 
            580                 585                 590         


Leu Cys Asp Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5220
<211> 2215
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5220
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg ctgcaggcgg tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caagcaaatc      780

tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc      840

tgggggtatt ttgactttaa cagattccac tgccactttt caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggccc aagagactca gcttcaagct cttcaacatc      960

caggtcaagg aggtcacgca gaatgaaggc accaagacca tcgccaataa cctcaccagc     1020

accatccagg tgtttacgga ctcggagtac cagctgccgt acgttctcgg ctctgcccac     1080

cagggctgcc tgcctccgtt cccggcggac gtgttcatga ttccccagta cggctaccta     1140

acactcaaca acggtagtca ggccgtggga cgctcctcct tctactgcct ggaatacttt     1200

ccttcgcaga tgctgagaac cggcaacaac ttccagttta cttacacctt cgaggacgtg     1260

cctttccaca gcagctacgc ccacagccag agcttggacc ggctgatgaa tcctctgatt     1320

gaccagtacc tgtactactt gtctcggact caaacaacag gaggcacgac aaatacgcag     1380

actctgggct tcagccaagg tgggcctaat acaatggcca atcaggcaaa gaactggctg     1440

ccaggaccct gttaccgcca gcagcgagta tcaaagacat ctgcggataa caacaacagt     1500

gaatactcgt ggactggagc taccaagtac cacctcaatg gcagagactc tctggtgaat     1560

ccgggcccgg ccatggcaag ccacaaggac gatgaagaaa agtttttttc ctcagagcgg     1620

ggttctcatc tttgggaagc aaggctcaga gaaaacaaat gtggacattg aaaaggtcat     1680

gattacagac gaagaggaaa tcaggacaac caatcccgtg gctacggagc agtatggttc     1740

tgtatctacc aacctccaga gaggcaacag acaagcagct accgcagatg tcaacacaca     1800

aggcgttctt ccaggcatgg tctggcagga cagagatgtg taccttcagg ggcccatctg     1860

ggcaaagatt ccacacacgg acggacattt tcacccctct cccctcatgg gtggattcgg     1920

acttaaacac cctccgcctc agatcctgat caagaacacg cctgtacctg cggatcctcc     1980

gaccaccttc aaccagtcaa agctgaactc tttcatcacc cagtattcta ctggccaagt     2040

cagcgtggag atcgagtggg agctgcagaa ggaaaacagc aagcgctgga accccgagat     2100

ccagtacacc tccaactact acaaatctac aagtgtggac tttgctgtta atacagaagg     2160

cgtgtactct gaaccccgcc ccattggcac ccgttacctc acccgtaatc tgtaa          2215


<210> 5221
<211> 737
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5221
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ala Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Lys Thr Gly Asn Asn Phe Gln Phe Thr Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Gly Thr Thr Asn Thr Gln Thr Leu Gly Phe 
    450                 455                 460                 


Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp 
                485                 490                 495     


Asn Asn Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu 
            500                 505                 510         


Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His 
        515                 520                 525             


Lys Asp Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe 
    530                 535                 540                 


Gly Lys Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met 
545                 550                 555                 560 


Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Gln Tyr Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala 
            580                 585                 590         


Ala Thr Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5222
<211> 737
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5222
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ala Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Lys Thr Gly Asn Asn Phe Gln Phe Thr Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Gly Thr Thr Asn Thr Gln Thr Leu Gly Phe 
    450                 455                 460                 


Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp 
                485                 490                 495     


Asn Asn Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu 
            500                 505                 510         


Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His 
        515                 520                 525             


Lys Asp Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe 
    530                 535                 540                 


Gly Lys Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met 
545                 550                 555                 560 


Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Gln Tyr Gly Ser Val Ser Thr Asn Leu Gln Gln Gly Asn Thr Gln Ala 
            580                 585                 590         


Ala Thr Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5223
<211> 737
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5223
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ala Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Gly Thr Thr Asn Thr Gln Thr Leu Gly Phe 
    450                 455                 460                 


Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp 
                485                 490                 495     


Asn Asn Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu 
            500                 505                 510         


Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His 
        515                 520                 525             


Lys Asp Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe 
    530                 535                 540                 


Gly Lys Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met 
545                 550                 555                 560 


Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Gln Tyr Gly Ser Val Ser Thr Asn Leu Gln Gln Gly Asn Thr Gln Ala 
            580                 585                 590         


Ala Thr Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5224
<211> 2214
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5224
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc ttggcagagc agtcttccag      360

gccaaaaaga ggatccttga gcctcttggt ctggttgagg aagcagctaa aacggctcct      420

ggaaagaaga ggcctgtaga tcagtctcct caggaaccgg actcatcatc tggtgttggc      480

aaatcgggca aacagcctgc cagaaaaaga ctaaatttcg gtcagactgg cgactcagag      540

tcagtcccag accctcaacc tctcggagaa ccaccagcag cccccacaag tttgggatct      600

aatacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaggg tgccgatggg      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacggga catcgggagg agccaccaac gacaacacct acttcggcta cagcaccccc      840

tgggggtatt ttgactttaa cagattccac tgccactttt caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggccc aagagactca gcttcaagct cttcaacatc      960

caggtcaagg aggtcacgca gaatgaaggc accaagacca tcgccaataa cctcaccagc     1020

accatccagg tgtttacgga ctcggagtac cagctgccgt acgttctcgg ctctgcgcac     1080

cagggctgcc tccctccgtt cccggcggac gtgttcatga ttccgcaata cggctacctg     1140

acgctcaaca atggcagcca agccgtggga cgttcatcct tttactgcct ggaatatttc     1200

ccttctcaga tgctgagaac gggcaacaac tttaccttca gctacacctt tgaggaagtg     1260

cctttccaca gcagctacgc gcacagccag agcttggacc ggctgatgaa tcctctgatt     1320

gaccagtacc tgtactactt gtctcggact caaacaacag gaggcacggc aaatacgcag     1380

actctgggct tcagccaagg tgggcctaat acaatggcca atcaggcaaa gaactggctg     1440

ccaggaccct gttaccgcca acaacgcgtc tcaacgacaa ccgggcaaaa caacaatagc     1500

aactttgcct ggactgctgg gaccaaatac catctgaatg gaagaaattc attggctaat     1560

cctggcatcg ctatggcaac acacaaagac gacgaggagc gtttttttcc cagtaacggg     1620

atcctgattt ttggcaaaca aaatgctgcc agagacaatg cggattacag cgatgtcatg     1680

ctcaccagcg aggaagaaat caaaaccact aaccctgtgg ctacagagga atacggtatc     1740

gtggcagata acttgcagca gcaaaacacg gctcctcaaa ttggaactgt caacagccag     1800

ggggccttac ccggtatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga cggcaacttc cacccgtctc cgctgatggg cggctttggc     1920

ctgaaacatc ctccgcctca gatcctgatc aagaacacgc ctgtacctgc ggatcctccg     1980

accaccttca accagtcaaa gctgaactct ttcatcacgc aatacagcac cggacaggtc     2040

agcgtggaga tcgagtggga gctgcagaag gaaaacagca agcgctggaa cccggagatc     2100

cagtacactt ccaactatta caagtctaat aatgttgaat ttgctgttaa tactgaaggt     2160

gtatatagtg aaccccgccc cattggcacc agatacctga ctcgtaatct gtaa           2214


<210> 5225
<211> 737
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5225
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly Phe 
    450                 455                 460                 


Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly Gln 
                485                 490                 495     


Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His Leu 
            500                 505                 510         


Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr His 
        515                 520                 525             


Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile Phe 
    530                 535                 540                 


Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val Met 
545                 550                 555                 560 


Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala Pro 
            580                 585                 590         


Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5226
<211> 2211
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5226
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcatcggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgaacatg ggccttgccc acctataaca accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc catttctcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaagctctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acgaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag ctgccgtacg ttctcggctc tgcccaccag     1080

ggctgcctgc ctccgttccc ggcggacgtg ttcatgattc cccagtacgg ctacctaaca     1140

ctcaacaacg gtagtcaggc cgtgggacgc tcctccttct actgcctgga atactttcct     1200

tcgcagatgc tgagaaccgg caacaacttc cagtttactt acaccttcga ggacgtgcct     1260

ttccacagca gctacgccca cagccagagc ttggaccggc tgatgaatcc tctgattgac     1320

cagtacctgt actacttgtc tcggactcaa acaacaggag gcacggcaaa tacgcagact     1380

ctgggcttca gccaaggtgg gcctaataca atggccaatc aggcaaagaa ctggctgcca     1440

ggaccctgtt accgccaaca acgcgtctca acgacaaccg ggcaaaacaa caatagcaat     1500

tttacctgga ctggtgcttc aaaatataac ctcaatgggc gtgaatccat catcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaagagag cgccggagct tcaaacactg cattggacaa tgtcatgatt     1680

acagacgaag aggaaattaa agccactaac cctgtggcca ccgaaagatt tgggaccgtg     1740

gcagtcaatt tccagagcag cagcacagac cctgcgaccg gagatgtgca tgctatggga     1800

gcattacctg gcatggtgtg gcaagataga gacgtgtacc tgcagggtcc catttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccaat actccacagg acaagtgagt     2040

gtggaaattg aatgggagct gcagaaagaa aacagcaagc gctggaatcc cgaagtgcag     2100

tacacatcca attatgcaaa atctgccaac gttgatttta ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtcccctgta a              2211


<210> 5227
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5227
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg 
        435                 440                 445             


Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly Phe Ser 
    450                 455                 460                 


Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5228
<211> 2211
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5228
atggctgctg acggttatct tccagattgg ctcgaggaca acctttctga aggcattcga       60

gagtggtggg cgctgcaacc tggagcccct aaacccaagg caaatcaaca acatcaggac      120

aacgctcggg gtcttgtgct tccgggttac aaatacctcg gacccggcaa cggactcgac      180

aagggggaac ccgtcaacgc agcggacgcg gcagccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggtga caacccctac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga tcagtctcct caggaaccgg actcatcatc tggtgttggc      480

aaatcgggca aacagcctgc cagaaaaaga ctaaatttcg gtcagactgg cgactcagag      540

tcagtcccag accctcaacc tctcggagaa ccaccagcag cccccacaag tttgggatct      600

aatacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca ccagaacctg ggccctgccc acttacaaca accatctcta caagcaaatc      780

tccagccaat caggagcttc aaacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact ttaacagatt ccactgccac ttctcaccac gtgactggca gcgactcatt      900

aacaacaact ggggattccg gcccaagaaa ctcagcttca agctcttcaa catccaagtt      960

aaagaggtca cgcagaacga tggcacgacg actattgcca ataaccttac cagcacggtt     1020

caagtgttta cggactcgga gtatcagctc ccgtacgtgc tcgggtcggc gcaccaaggc     1080

tgtctcccgc cgtttccagc ggacgtcttc atggtccctc agtatggata cctcaccctg     1140

aacaacggaa gtcaagcggt gggacgctca tccttttact gcctggagta cttcccttcg     1200

cagatgctaa ggactggaaa taacttccaa ttcagctata ccttcgagga tgtacctttt     1260

cacagcagct acgctcacag ccagagtttg gatcgcttga tgaatcctct tattgatcag     1320

tatctgtact acctgaacag aacgcaagga acaacctctg gaacaaccaa ccaatcacgg     1380

ctgcttttta gccaggctgg gcctcagtct atgtctttgc aggccagaaa ttggctacct     1440

gggccctgct accggcaaca gagactttca aagactgcta acgacaacaa caacagtaac     1500

tttccttgga cagcggccag caaatatcat ctcaatggcc gcgactcgct ggtgaatcca     1560

ggaccagcta tggccagtca caaggacgat gaagaaaaat ttttccctat gcacggcaat     1620

ctaatatttg gcaaagaagg gacaacggca agtaacgcag aattagataa tgtaatgatt     1680

acggatgaag aagagattcg taccaccaat cctgtggcaa cagagcagta tggaactgtg     1740

gcaaataact tgcagagctc aaatacagct cccacgacta gaactgtcaa tgatcagggg     1800

gccttacctg gcatggtgtg gcaagatcgt gacgtgtacc ttcaaggacc tatctgggca     1860

aagattcctc acacggatgg acactttcat ccttctcctc tgatgggagg ctttggactg     1920

aaacatccgc ctcctcaaat catgatcaaa aatactccgg taccggcaaa tcctccgacg     1980

actttcagcc cggccaagtt tgcttcattt atcactcagt actccactgg acaggtcagc     2040

gtggaaattg agtgggagct acagaaagaa aacagcaaac gttggaatcc agagattcag     2100

tacacttcca actacaacaa gtctgttaat gtggacttta ctgtagacac taatggtgtt     2160

tatagtgaac ctcgccccat tggcacccgt taccttaccc gtcccctgta a              2211


<210> 5229
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5229
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Gln Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5230
<211> 2211
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5230
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagaaag gccaacagcc cgctaaaaag agactcaatt ttggtcagac tggcgactca      540

gagtcagtcc ccgacccaca acctctcgga gaacctccag caacccccgc tgctgtggga      600

cctactacaa tggcttcagg cggtggcgca ccaatggcag acaataacga gggtgccgat      660

ggagtgggta attcctcagg aaattggcat tgcgattccc aatggctggg cgacagagtc      720

atcaccacca gcaccagaac ctgggccctg cccacttaca acaaccatct ctacaagcaa      780

atctccagcc aatcaggagc ttcaaacgac aaccactact ttggctacag caccccttgg      840

gggtattttg actttaacag attccactgc cacttttcac cacgtgactg gcaaagactc      900

atcaacaaca actggggatt ccgacccaag agactcaact tcaagctctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acgaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag ttgccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcagtacgg ctacctaacg     1140

ctcaacaatg gcagccaagc cgtgggacgt tcatcctttt actgcctgga atatttccct     1200

tctcagatgc tgagaacggg caacaacttt accttcagct acacttttga ggacgttcct     1260

ttccacagca gctacgctca cagccagagt ctggaccgtc tcatgaatcc tctcatcgac     1320

cagtacctgt attacttgag cagaacaaac actccaagtg gaaccaccac gcagtcaagg     1380

cttcagtttt ctcaggccgg agcgagtgac attcgggacc agtctaggaa ctggcttcct     1440

ggaccctgtt accgccagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaat     1500

tttacctgga ctggtgcttc aaaatataac cttaatgggc gtgaatctat aatcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaagagag cgccggagct tcaaacactg cattggacaa tgtcatgatt     1680

acagacgaag aggaaattaa agccactaac cctgtggcca ccgaaagatt tgggaccgtg     1740

gcagtcaatt tccagagcag cagcacagac cctgcgaccg gagatgtgca tgttatggga     1800

gccttacctg gaatggtgtg gcaagacaga gacgtatacc tgcagggtcc tatttgggcc     1860

aaaattcctc acacggatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccaat actccacagg acaagtgagt     2040

gtggaaattg aatgggagct gcagaaagaa aacagcaagc gctggaatcc cgaagtgcag     2100

tacacatcca attatgcaaa atctgccaac gttgatttta ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt taccttaccc gtcccctgta a              2211


<210> 5231
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5231
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg 
        435                 440                 445             


Thr Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser 
    450                 455                 460                 


Gln Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5232
<211> 2211
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5232
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagcccct aaacccaagg caaatcaaca acatcaggac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagaaag gccaacagcc cgctaaaaag agactcaatt ttggtcagac tggcgactca      540

gagtcagtcc ccgacccaca acctctcgga gaacctccag caacccccgc tgctgtggga      600

cctactacaa tggcttcagg cggtggcgca ccaatggcag acaataacga gggtgccgat      660

ggagtgggta attcctcagg aaattggcat tgcgattccc aatggctggg cgacagagtc      720

atcaccacca gcaccagaac ctgggccctg cccacttaca acaaccatct ctacaagcaa      780

atctccagcc aatcaggagc ttcaaacgac aaccactact ttggctacag caccccttgg      840

gggtattttg actttaacag attccactgc cacttttcac cacgtgactg gcaaagactc      900

atcaacaaca actggggatt ccgacccaag agactcaact tcaagctctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acgaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag ttgccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcagtacgg ctacctaacg     1140

ctcaacaatg gcagccaagc cgtgggacgt tcatcctttt actgcctgga atatttccct     1200

tctcagatgc tgagaacggg caacaacttt accttcagct acacttttga ggacgttcct     1260

ttccacagca gctacgctca cagccagagt ctggaccgtc tcatgaatcc cctcatcgac     1320

cagtacctgt attacttgag cagaacaaac actccaagtg gaaccaccac gcagtcaagg     1380

cttcagtttt ctcaggccgg agcgagtgac attcgggacc agtctaggaa ctggcttcct     1440

ggaccctgtt accggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaac     1500

tttacctgga ctggtgcttc aaaatataac cttaatgggc gtgaatctat aatcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaggagag cgccggagct tcaaacactg cattggacaa tgtcatgatc     1680

acagacgaag aggaaatcaa agccactaac cccgtggcca ccgaaagatt tgggactgtg     1740

gcagtcaatc tccagagcag cagcacagac cctgcgaccg gagatgtgca tgttatggga     1800

gccttacctg gaatggtgtg gcaagacaga gacgtgtacc tgcagggtcc tatttgggcc     1860

aaaattcctc acacggatgg acactttcac ccgtctcctc tcatgggcgg ctttggactt     1920

aagcacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggca     1980

gagttttcgg ctacaaagtt tgcttcattc atcacccagt attccacagg acaagtgagt     2040

gtggaaattg aatgggagct gcagaaagaa aacagcaagc gctggaatcc cgaagtgcag     2100

tacacatcca attatgcaaa atctgccaac gttgatttta ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtcccctgta a              2211


<210> 5233
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5233
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg 
        435                 440                 445             


Thr Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser 
    450                 455                 460                 


Gln Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5234
<211> 2214
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5234
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc ttggcagagc agtcttccag      360

gccaaaaaga ggatccttga gcctcttggt ctggttgagg aagcagctaa aacggctcct      420

ggaaagaaga ggcctgtaga tcagtctcct caggaaccgg actcatcatc tggtgttggc      480

aaatcgggca aacagcctgc cagaaaaaga ctaaatttcg gtcagactgg cgactcagag      540

tcagtcccag accctcaacc tctcggagaa ccaccagcag cccccacaag tttgggatct      600

aatacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaggg tgccgatggg      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat gactggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacggga catcgggagg agccaccaac gacaacacct acttcggcta cagcaccccc      840

tgggggtatt ttgactttaa cagattccac tgccactttt caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggccc aagagactca gcttcaagct cttcaacatc      960

caggtcaagg aggtcacgca gaatgaaggc accaagacca tcgccaataa cctcaccagc     1020

accatccagg tgtttacgga ctcggagtac cagctgccgt acgttctcgg ctctgcgcac     1080

cagggctgcc tccctccgtt cccggcggac gtgttcatga ttccgcaata cggctacctg     1140

acgctcaaca atggcagcca agccgtggga cgttcatcct tttactgcct ggaatatttc     1200

ccttctcaga tgctgagaac gggcaacaac tttaccttca gctacacctt tgaggaagtg     1260

cctttccaca gcagctacgc gcacagccag agcttggacc ggctgatgaa tcctctgatt     1320

gaccagtacc tgtactactt gtctcggact caaacaacag gaggcacggc aaatacgcag     1380

actctgggct tcagccaagg tgggcctaat acaatggcca atcaggcaaa gaactggctg     1440

ccaggaccct gttaccgcca acaacgcgtc tcaacgacaa ccgggcaaaa caacaatagc     1500

aactttgcct ggactgctgg gaccaaatac catctgaatg gaagaaattc attggctaat     1560

cctggcatcg ctatggcaac acacaaagac gacgaggagc gtttttttcc cagtaacggg     1620

atcctgattt ttggcaaaca aaatgctgcc agagacaatg cggattacag cgatgtcatg     1680

ctcaccagcg aggaagaaat caaaaccact aaccctgtgg ctacagagga atacggtatc     1740

gtggcagata acttgcagca gcaaaacacg gctcctcaaa ttggaactgt caacagccag     1800

ggggccttac ccggtatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga cggcaacttc cacccgtctc cgctgatggg cggctttggc     1920

ctgaaacatc ctccgcctca gatcctgatc aagaacacgc ctgtacctgc ggatcctccg     1980

accaccttca accagtcaaa gctgaactct ttcatcacgc aatacagcac cggacaggtc     2040

agcgtggaga tcgagtggga gctgcagaag gaaaacagca agcgctggaa cccggagatc     2100

cagtacactt ccaactatta caagtctaat aatgttgaat ttgctgttaa tactgaaggt     2160

gtatatagtg aaccccgccc cattggcacc agatacctga ctcgtaatct gtaa           2214


<210> 5235
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5235
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Leu Gly Asp Arg Val Ile Thr 
225                 230                 235                 240 


Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr 
                245                 250                 255     


Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp Asn Thr 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg 
        435                 440                 445             


Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly Phe Ser 
    450                 455                 460                 


Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr His Lys 
        515                 520                 525             


Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val Met Leu 
545                 550                 555                 560 


Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala Pro Gln 
            580                 585                 590         


Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 5236
<211> 2214
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5236
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc ttggcagagc agtcttccag      360

gccaaaaaga ggatccttga gcctcttggt ctggttgagg aagcagctaa aacggctcct      420

ggaaagaaga ggcctgtaga tcagtctcct caggaaccgg actcatcatc tggtgttggc      480

aaatcgggca aacagcctgc cagaaaaaga ctaaatttcg gtcagactgg cgactcagag      540

tcagtcccag accctcaacc tctcggagaa ccaccagcag cccccacaag tttgggatct      600

aatacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaggg tgccgatggg      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacggga catcgggagg agccaccaac gacaacacct acttcggcta cagcaccccc      840

tgggggtatt ttgactttaa cagattccac tgccactttt caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggccc aagagactca gcttcaagct cttcaacatc      960

caggtcaagg aggtcacgca gaatgaaggc accaagacca tcgccaataa cctcaccagc     1020

accatccagg tgtttacgga ctcggagtac cagctgccgt acgttctcgg ctctgcgcac     1080

cagggctgcc tccctccgtt cccggcggac gtgttcatga ttccgcaata cggctacctg     1140

acgctcaaca atggcagcca agccgtggga cgttcatcct tttactgcct ggaatatttc     1200

ccttctcaga tgctgagaac gggcaacaac tttaccttca gctacacctt tgaggaagtg     1260

ccttttcaca gcagctacgc gcacagccag agcttggacc ggctgatgaa tcctctgatt     1320

gaccagtacc tgtactactt gtctcggact caaacaacag gaggcacggc aaatacgcag     1380

actctgggct tcagccaagg tgggcctaat acaatggcca atcaggcaaa gaactggctg     1440

ccaggaccct gttaccgcca acaacgcgtc tcaacgacaa ccgggcaaaa caacaatagc     1500

aactttgcct ggactgctgg gaccaaatac catctgaatg gaagaaattc attggctaat     1560

cctggcatcg ctatggcaac acacaaagac gacgaggagc gtttttttcc cagtaacggg     1620

atcctgattt ttggcaaaca aaatgctgcc agagacaatg cggattacag cgatgtcatg     1680

ctcaccagcg aggaagaaat caaaaccact aaccctgtgg ctacagagga atacggtatc     1740

gtggcagata acttgcagca gcaaaacacg gctcctcaaa ttggaactgt caacagccag     1800

ggggccttac ccggtatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga cggcaacttc cacccgtctc cgctgatggg cggctttggc     1920

ctgaaacatc ctccgcctca gatcctgatc aagaacacgc ctgtacctgc ggatcctccg     1980

accaccttca accagtcaaa gctgaactct ttcatcacgc aatacagcac cggacaggtc     2040

agcgtggaga tcgagtggga gctgcagaag gaaaacagca agcgctggaa cccggagatc     2100

cagtacactt ccaactatta caagtctaat aatgttgaat ttgctgttaa tactgaaggt     2160

gtatatagtg aaccccgccc cattggcacc agatacctga ctcgtaatct gtaa           2214


<210> 5237
<211> 737
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5237
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly Phe 
    450                 455                 460                 


Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly Gln 
                485                 490                 495     


Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His Leu 
            500                 505                 510         


Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr His 
        515                 520                 525             


Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile Phe 
    530                 535                 540                 


Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val Met 
545                 550                 555                 560 


Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala Pro 
            580                 585                 590         


Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5238
<211> 2211
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5238
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagcccct aaacccaagg caaatcaaca acatcaggac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagaaag gccaacagcc cgctaaaaag agactcaatt ttggtcagac tggcgactca      540

gagtcagtcc ccgacccaca acctctcgga gaacctccag caacccccgc tgctgtggga      600

cctactacaa tggcttcagg cggtggcgca ccaatggcag acaataacga gggtgccgat      660

ggagtgggta attcctcagg aaattggcat tgcgattccc aatggctggg cgacagagtc      720

atcaccacca gcaccagaac ctgggccctg cccacttaca acaaccatct ctacaagcaa      780

atctccagcc aatcaggagc ttcaaacgac aaccactact ttggctacag caccccttgg      840

gggtattttg actttaacag attccactgc cacttttcac cacgtgactg gcaaagactc      900

atcaacaaca actggggatt ccgacccaag agactcaact tcaagctctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acgaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag ttgccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcagtacgg ctacctaacg     1140

ctcaacaatg gcagccaagc cgtgggacgt tcatcctttt actgcctgga atatttccct     1200

tctcagatgc tgagaacggg caacaacttt accttcagct acacttttga ggacgttcct     1260

ttccacagca gctacgctca cagccagagt ctggaccgtc tcatgaatcc tctcatcgac     1320

cagtacctgt attacttgag cagaacaaac actccaagtg gaaccaccac gcagtcaagg     1380

cttcagtttt ctcaggccgg agcgagtgac attcgggacc agtctaggaa ctggcttcct     1440

ggaccctgtt accgccagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaat     1500

tttacctgga ctggtgcttc aaaatataac cttaatgggc gtgaatctat aatcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaagagag cgccggagct tcaaacactg cattggacaa tgtcatgatt     1680

acagacgaag aggaaattaa agccactaac cctgtggcca ccgaaagatt tgggaccgtg     1740

gcagtcaatt tccagagcag cagcacagac cctgcgaccg gagatgtgca tgctatggga     1800

gcattacctg gcatggtgtg gcaagataga gacgtgtacc tgcagggtcc catttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccaat actccacagg acaagtgagt     2040

gtggaaattg aatgggagct gcagaaagaa aacagcaagc gctggaatcc cgaagtgcag     2100

tacacatcca attatgcaaa atctgccaac gttgatttta ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt taccttaccc gtcccctgta a              2211


<210> 5239
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5239
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg 
        435                 440                 445             


Thr Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser 
    450                 455                 460                 


Gln Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5240
<211> 2211
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5240
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tccgggttac aaatacctcg gacccggtaa cggactcgac      180

aaaggagagc cggtcaacga ggcggacgcg gcagccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctccc      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctctac gggcatcggc      480

aagaaaggcc aacagcccgc cagaaaaaga ctcaatttcg gtcagactgg cgactcagag      540

tcagttccag accctcaacc tctcggagaa cctccagcag cgccctctgg tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgaacatg ggccttgccc acctataaca accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aacacctact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc catttctcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaaactctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acgaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag ttgccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcagtacgg ctacctaacg     1140

ctcaacaatg gcagccaggc agtgggacgg tcatcctttt actgcctgga atatttccca     1200

tcgcagatgc tgagaacggg caataacttt accttcagct acaccttcga ggacgtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

cagtacctgt attacctgaa cagaactcag aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgggggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaat     1500

tttacctgga ctggtgcttc aaaatataac ctcaatgggc gtgaatccat catcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaagagag cgccggagct tcaaacactg cattggacaa tgtcatgatt     1680

acagacgaag aggaaattaa agccactaac cctgtggcca ccgaaagatt tgggaccgtg     1740

gcagtcaatt tccagagcag cagcacagac cctgcgaccg gagatgtgca tgttatggga     1800

gccttacctg gaatggtgtg gcaagacaga gacgtatacc tgcagggtcc tatttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggca     1980

gagttttcgg ctacaaagtt tgcttcattc atcacccagt attccacagg acaagtgagc     2040

gtggagattg aatgggagct gcagaaagaa aacagcaaac gctggaatcc cgaagtgcag     2100

tatacatcta actatgcaaa atctgccaac gttgatttca ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtcccctgta a              2211


<210> 5241
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5241
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Thr Gly Ile Gly 
145                 150                 155                 160 


Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn Thr 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5242
<211> 2205
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5242
atggctgctg acggttatct tccagattgg ctcgaggaca acctttctga aggcattcgt       60

gagtggtggg ctctgaaacc tggagtccct caacccaaag cgaaccaaca acaccaggac      120

aaccgtcggg gtcttgtgct tccgggttac aaatacctcg gacccggtaa cggactcgac      180

aaaggagagc cggtcaacga ggcggacgcg gcagccctcg aacacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctccgc gggtattggc      480

aaatcgggtg cacagcccgc taaaaagaga ctcaatttcg gtcagactgg cgacacagag      540

tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca gtggcagaca ataacgaagg tgccgatgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca gcgactcatc      900

aacaacaact ggggattccg gcccaagaga ctcagcttca agctcttcaa catccaggtc      960

aaagaggtta cggacaacaa tggagtcaag accatcgcca ataaccttac cagcacggtc     1020

caggtcttca cggactcaga ctatcagctc ccgtacgtgc tcgggtcggc tcacgagggc     1080

tgcctcccgc cgttcccagc ggacgttttc atgattcctc agtacgggta tctgacgctt     1140

aatgatggaa gccaggccgt gggtcgttcg tccttttact gcctggaata tttcccgtcg     1200

caaatgctaa gaacgggtaa caacttccag ttcagctacg agtttgagaa cgtacctttc     1260

catagcagct acgctcacag ccaaagcctg gaccgactaa tgaatccact catcgaccaa     1320

tacttgtact atctctcaaa gactattaac ggttctggac agaatcaaca aacgctaaaa     1380

ttcagtgtgg ccggacccag caacatggct gtccagggaa gaaactacat acctggaccc     1440

agctaccgac aacaacgtgt ctcaaccact gtgactcaaa acaacaacag cgaatttgct     1500

tggcctggag cttcttcttg ggctctcaat ggacgtaata gcttgatgaa tcctggacct     1560

gctatggcca gccacaaaga aggagaggac cgtttctttc ctttgtctgg atctttaatt     1620

tttggcaaac aaggaactgg aagagacaac gtggatgcgg acaaagtcat gataaccaac     1680

gaagaagaaa ttaaaactac taacccggta gcaacggagt cctatggaca agtggccaca     1740

aaccaccaga gtgcccaagc acaggcgcag accggctggg ttcaaaacca aggaatactt     1800

ccgggtatgg tttggcagga cagagatgtg tacctgcaag gacccatctg ggccaagatt     1860

cctcacacgg acggcaactt ccacccgtct ccgctgatgg gcggctttgg cctgaaacat     1920

cctccgcctc agatcctgat caagaacacg cctgtacctg cggatcctcc gaccaccttc     1980

aaccagtcaa agctgaactc tttcatcacg caatacagca ccggacaggt cagcgtggaa     2040

attgaatggg agctgcagaa ggaaaacagc aagcgctgga atcccgaagt gcagtataca     2100

tctaactatg caaaatctgc caacgttgat ttcactgtgg acaacaatgg actttatact     2160

gagcctcgcc ccattggcac ccgttacctc acccgtcccc tgtaa                     2205


<210> 5243
<211> 734
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5243
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Val Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Arg Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu Phe Glu 
                405                 410                 415     


Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr 
        435                 440                 445             


Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser Val Ala 
    450                 455                 460                 


Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro Gly Pro 
465                 470                 475                 480 


Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn Asn Asn 
                485                 490                 495     


Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn Gly Arg 
            500                 505                 510         


Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys Glu Gly 
        515                 520                 525             


Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly Lys Gln 
    530                 535                 540                 


Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile Thr Asn 
545                 550                 555                 560 


Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser Tyr Gly 
                565                 570                 575     


Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln Thr Gly 
            580                 585                 590         


Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp Arg 
        595                 600                 605             


Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp 
    610                 615                 620                 


Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His 
625                 630                 635                 640 


Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro 
                645                 650                 655     


Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile Thr Gln Tyr 
            660                 665                 670         


Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu 
        675                 680                 685             


Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn Tyr Ala 
    690                 695                 700                 


Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu Tyr Thr 
705                 710                 715                 720 


Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 


<210> 5244
<211> 2211
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5244
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagt gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcatcggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgcacctg ggccttgccc acctacaata accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc catttctcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaagctctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acaaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag cttccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcaatacgg ctacctgacg     1140

ctcaacaatg gcagccaagc cgtgggacgt tcatcctttt actgcctgga atatttccct     1200

tctcagatgc tgagaacggg caacaacttt accttcagct acacctttga ggaagtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

caatacctgt attacctgaa cagaactcaa aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgtgggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaat     1500

tttacctgga ctggtgcttc aaaatataac ctcaatgggc gtgaatccat catcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaggagag cgccggagct tcaaacactg cattggacaa tgtcatgatc     1680

accgacgaag aggaaatcaa agccactaac cccgtggcca ccgaaagatt tgggactgtg     1740

gcagtcaatc tccagagcag cagcacagac cctgcgaccg gagatgtgca tgttatggga     1800

gccttacctg gcatggtgtg gcaagataga gacgtgtacc tgcagggtcc catttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccaat actccacagg acaagtgagt     2040

gtggaaattg aatgggagct gcagaaagaa aacagcaagc gctggaatcc cgaagtgcag     2100

tacacatcca attatgcaaa atctgccaac gttgatttta ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtcccctgta a              2211


<210> 5245
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5245
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Trp Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5246
<211> 2214
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5246
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc ttggcagagc agtcttccag      360

gccaaaaaga ggatccttga gcctcttggt ctggttgagg aagcagctaa aacggctcct      420

ggaaagaaga ggcctgtaga tcagtctcct caggaaccgg actcatcatc tggtgttggc      480

aaatcgggca aacagcctgc cagaaaaaga ctaaatttcg gtcagactgg cgactcagag      540

tcagtcccag accctcaacc tctcggagaa ccaccagcag cccccacaag tttgggatct      600

aatacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaggg tgccgatggg      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacggga catcgggagg agccaccaac gacaacacct acttcggcta cagcaccccc      840

tgggggtatt ttgactttaa cagattccac tgccactttt caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggccc aagagactca gcttcaagct cttcaacatc      960

caggtcaagg aggtcacgca gaatgaaggc accaagacca tcgccaataa cctcaccagc     1020

accatccagg tgtttacgga ctcggagtac cagctgccgt acgttctcgg ctcggcgcac     1080

cagggctgcc tccctccgtt cccggcggac gtcttcatgg tgccacagta tggatacctg     1140

acgctcaaca atggcagcca agccgtggga cgttcatcct tttactgcct ggaatatttc     1200

ccttctcaga tgctgagaac gggcaacaac tttaccttca gctacacctt tgaggaagtg     1260

cctttccaca gcagctacgc gcacagccag agcttggacc ggctgatgaa tcctctgatt     1320

gaccagtacc tgtactactt gtctcggact caaacaacag gaggcacggc aaatacgcag     1380

actctgggct tcagccaagg tgggcctaat acaatggcca atcaggcaaa gaactggctg     1440

ccaggaccct gttaccgcca acaacgcgtc tcaacgacaa ccgggcaaaa caacaatagc     1500

aactttgcct ggactgctgg gaccaaatac catctgaatg gaagaaattc attggctaat     1560

cctggcatcg ctatggcaac acacaaagac gacgaggagc gtttttttcc cagtaacggg     1620

atcctgattt ttggcaaaca aaatgctgcc agagacaatg cggattacag cgatgtcatg     1680

ctcaccagcg aggaagaaat caaaaccact aaccctgtgg ctacagagga atacggtatc     1740

gtggcagata acttgcagca gcaaaacacg gctcctcaaa ttggaactgt caacagccag     1800

ggggacttac ccggtatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga cggcaacttc cacccgtctc cgctgatggg cggctttggc     1920

ctgaaacatc ctccgcctca gatcctgatc aagaacacgc ctgtacctgc ggatcctccg     1980

accaccttca accagtcaaa gctgaactct ttcatcacgc aatacagcac cggacaggtc     2040

agcgtggaga tcgagtggga gctgcagaag gaaaacagca agcgctggaa cccggagatc     2100

cagtacactt ccaactatta caagtctaat aatgttgaat ttgctgttaa tactgaaggt     2160

gtatatagtg aaccccgccc cattggcacc agatacctga ctcgtaatct gtaa           2214


<210> 5247
<211> 737
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5247
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly Phe 
    450                 455                 460                 


Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly Gln 
                485                 490                 495     


Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His Leu 
            500                 505                 510         


Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr His 
        515                 520                 525             


Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile Phe 
    530                 535                 540                 


Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val Met 
545                 550                 555                 560 


Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala Pro 
            580                 585                 590         


Gln Ile Gly Thr Val Asn Ser Gln Gly Asp Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5248
<211> 2205
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5248
atggctgctg acggttatct tccagattgg ctcgaggaca acctttctga aggcattcgt       60

gagtggtggg ctctgaaacc tggagtccct caacccaaag cgaaccaaca acaccaggac      120

aactgtcggg gtcttgtgct tccgggttac aaatacctcg gacccggtaa cggactcgac      180

aaaggagagc cggtcaacga ggcggacgcg gcagccctcg aacacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

accaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctccgc gggtattggc      480

aaatcgggtg cacagcccgc taaaaagaga ctcaatttcg gtcagactgg cgacacagag      540

tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca gtggcagaca ataacgaagg tgccgatgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca gcgactcatc      900

aacaacaact ggggattccg gcccaagaga ctcagcttca agctcttcaa catccaggtc      960

aaagaggtta cggacaacaa tggagtcaag accatcgcca ataaccttac cagcacggtc     1020

caggtcttca cggactcaga ctatcagctc ccgtacgtgc tcgggtcggc tcacgagggc     1080

tgcctcccgc cgttcccagc ggacgttttc atgattcctc agtacgggta tctgacgctt     1140

aatgatggaa gccaggccgt gggtcgttcg tccttttact gcctggaata tttcccgtcg     1200

caaatgctaa gaacgggtaa caacttccag ttcagctacg agtttgagaa cgtacctttc     1260

catagcagct acgctcacag ccaaagcctg gaccgactaa tgaatccact catcgaccaa     1320

tacttgtact atctctcaaa gactattaac ggttctggac agaatcaaca aacgctaaaa     1380

ttcagtgtgg ccggacccag caacatggct gtccagggaa gaaactacat acctggaccc     1440

agctaccgac aacaacgtgt ctcaaccact gtgactcaaa acaacaacag cgaatttgct     1500

tggcctggag cttcttcttg ggctctcaat ggacgtaata gcttgatgaa tcctggacct     1560

gctatggcca gccacaaaga aggagaggac cgtttctttc ctttgtctgg atctttaatt     1620

tttggcaaac aaggaactgg aagagacaac gtggatgcgg acaaagtcat gataaccaac     1680

gaagaagaaa ttaaaactac taacccggta gcaacggagt cctatggaca agtggccaca     1740

aaccaccaga gtgcccaagc acaggcgcag accggctggg ttcaaaacca aggaatactt     1800

ccgggtatgg tttggcagga cagagatgtg tacctgcaag gacccatctg ggccaagatt     1860

cctcacacgg acggcaactt ccacccgtct ccgctgatgg gcggctttgg cctgaaacat     1920

cctccgcctc agatcctgat caagaacacg cctgttcctg cgaatcctcc ggcggagttt     1980

tcagctacaa agtttgcttc attcatcacc cagtactcca caggacaagt gagtgtggaa     2040

attgaatggg agctgcagaa agaaaacagc aagcgctgga atcccgaagt gcagtacaca     2100

tccaattatg caaaatctgc caacgttgat tttactgtgg acaacaatgg actttatact     2160

gagcctcgcc ccattggcac ccgttacctt accaaacctc tgtaa                     2205


<210> 5249
<211> 734
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5249
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Val Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Cys Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Thr Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu Phe Glu 
                405                 410                 415     


Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr 
        435                 440                 445             


Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser Val Ala 
    450                 455                 460                 


Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro Gly Pro 
465                 470                 475                 480 


Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn Asn Asn 
                485                 490                 495     


Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn Gly Arg 
            500                 505                 510         


Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys Glu Gly 
        515                 520                 525             


Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly Lys Gln 
    530                 535                 540                 


Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile Thr Asn 
545                 550                 555                 560 


Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser Tyr Gly 
                565                 570                 575     


Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln Thr Gly 
            580                 585                 590         


Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp Arg 
        595                 600                 605             


Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp 
    610                 615                 620                 


Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His 
625                 630                 635                 640 


Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn Pro 
                645                 650                 655     


Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr Gln Tyr 
            660                 665                 670         


Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu 
        675                 680                 685             


Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn Tyr Ala 
    690                 695                 700                 


Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu Tyr Thr 
705                 710                 715                 720 


Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Lys Pro Leu 
                725                 730                 


<210> 5250
<211> 2211
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5250
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagcccct aaacccaagg caaatcaaca acatcaggac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagaaag gccaacagcc cgctaaaaag agactcaatt ttggtcagac tggcgactca      540

gagtcagtcc ccgacccaca acctctcgga gaacctccag caacccccgc tgctgtggga      600

cctactacaa tggcttcagg cggtggcgca ccaatggcag acaataacga gggtgccgat      660

ggagtgggta attcctcagg aaattggcat tgcgattccc aatggctggg cgacagagtc      720

atcaccacca gcaccagaac ctgggccctg cccacttaca acaaccatct ctacaagcaa      780

atctccagcc aatcaggagc ttcaaacgac aaccactact ttggctacag caccccttgg      840

gggtattttg actttaacag attccactgc cacttttcac cacgtgactg gcaaagactc      900

atcaacaaca actggggatt ccgacccaag agactcaact tcaagctctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acgaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag ttgccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcagtacgg ctacctaacg     1140

ctcaacaatg gcagccaagc cgtgggacgt tcatcctttt actgcctgga atatttccct     1200

tctcagatgc tgagaacggg caacaacttt accttcagct acacttttga ggacgttcct     1260

ttccacagca gctacgctca cagccagagt ctggaccgtc tcatgaatcc tctcatcgac     1320

cagtacctgt attacttgag cagaacaaac actccaagtg gaaccaccac gcagtcaagg     1380

cttcagtttt ctcaggccgg agcgagtgac attcgggacc agtctaggaa ctggcttcct     1440

ggaccctgtt accgccagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaat     1500

tttacctgga ctggtgcttc aaaatataac cttaatgggc gtgaatctat aatcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaagagag cgccggagct tcaaacactg cattggacaa tgtcatgatc     1680

acagacgaag aggaaatcaa agccactaac cccgtggcca ccgaaagatt tgggactgtg     1740

gcagtcaatc tccagagcag cagcacagac cctgcgaccg gagatgtgca tgttatggga     1800

gcattacctg gcatggtgtg gcaagataga gacgtgtacc tgcagggtcc catttgggcc     1860

aaaattcctc acacagatgg acactttcac ccgtctcctc ttatgggcgg ctttggactc     1920

aagaacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggcg     1980

gagttttcag ctacaaagtt tgcttcattc atcacccaat actccacagg acaagtgagt     2040

gtggaaattg aatgggagct gcagaaagaa aacagcaagc gctggaatcc cgaagtgcag     2100

tacacatcca attatgcaaa atctgccaac gttgatttta ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt taccttaccc gtcccctgta a              2211


<210> 5251
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5251
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg 
        435                 440                 445             


Thr Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser 
    450                 455                 460                 


Gln Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5252
<211> 2214
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5252
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc ttggcagagc agtcttccag      360

gccaaaaaga ggatccttga gcctcttggt ctggttgagg aagcagctaa aacggctcct      420

ggaaagaaga ggcctgtaga tcagtctcct caggaaccgg actcatcatc tggtgttggc      480

aaatcgggca aacagcctgc cagaaaaaga ctaaatttcg gtcagactgg cgactcagag      540

tcagtcccag accctcaacc tctcggagaa ccaccagcag cccccacaag tttgggatct      600

aatacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaggg tgccgatggg      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacggga catcgggagg agccaccaac gacaacacct acttcggcta cagcaccccc      840

tgggggtatt ttgactttaa cagattccac tgccactttt caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggccc aagagactca gcttcaagct cttcaacatc      960

caggtcaagg aggtcacgca gaatgaaggc accaagacca tcgccaataa cctcaccagc     1020

accatccagg tgtttacgga ctcggagtac cagctgccgt acgttctcgg ctctgcgcac     1080

cagggctgcc tccctccgtt cccggcggac gtgttcatga ttccgcaata cggctacctg     1140

acgctcaaca atggcagcca agccgtggga cgttcatcct tttactgcct ggaatatttc     1200

ccttctcaga tgctgagaac gggcaacaac tttaccttca gctacacctt tgaggaagtg     1260

cctttccaca gcagctacgc gcacagccag agcttggacc ggctgatgaa tcctctgatt     1320

gaccagtacc tgtactactt gtctcggact caaacaacag gaggcacggc aaatacgcag     1380

actctgggct tcagccaagg tgggcctaat acaatggcca atcaggcaaa gaactggctg     1440

ccaggaccct gttaccgcca acaacgcgtc tcaacgacaa ccgggcaaaa caacaatagc     1500

aactttgcct ggactgctgg gaccaaatac catctgaatg gaagaaattc attggctaat     1560

cctggcatcg ctatggcaac acacaaagac gacgaggagc gtttttttcc cagtaacggg     1620

atcctgattt ttggcaaaca aaatgctgcc agagacaatg cggattacag cgatgtcatg     1680

ctcaccagcg aggaagaaat caaaaccact aaccctgtgg ctacagagga atacggtatc     1740

gtggcagata acttgcagca gcaaaacacg gctcctcaaa ttggaactgt caacagccag     1800

ggggccttac ccggtatggt ctggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga cggcaacttc cacccgtctc cgctgatggg cggctttggc     1920

ctgaaacatc ctccgcctca gatcctgatc aagaacacgc ctgtacctgc ggatcctccg     1980

accaccttca accagtcaaa gctgaactct ttcatcacgc aatacagcac cggacaggtc     2040

agcgtggaga tcgagtggga gctgcagaag gaaaacagca agcgctggaa cccggagatc     2100

cagtacactt ccaactatta caagtctaat aatgttgaat ttgctgttaa tactgaaggt     2160

gtatatagtg aaccccgccc cattggcacc agatacctga ctcgtaatct gtaa           2214


<210> 5253
<211> 737
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5253
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly Phe 
    450                 455                 460                 


Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly Gln 
                485                 490                 495     


Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His Leu 
            500                 505                 510         


Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr His 
        515                 520                 525             


Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile Phe 
    530                 535                 540                 


Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val Met 
545                 550                 555                 560 


Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala Pro 
            580                 585                 590         


Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5254
<211> 2205
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5254
atggctgctg acggttatct tccagattgg ctcgaggaca acctttctga aggcattcgt       60

gagtggtggg ctctgaaacc tggagtccct caacccaaag cgaaccaaca acaccaggac      120

aaccgtcggg gtcttgtgct tccgggttac aaatacctcg gacccggtaa cggactcgac      180

aaaggagagc cggtcaacga ggcggacgcg gcagccctcg aacacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctccgc gggtattggc      480

aaatcgggtg cacagcccgc taaaaagaga ctcaatttcg gtcagactgg cgacacagag      540

tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca gtggcagaca ataacgaagg tgccgatgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca gcgactcatc      900

aacaacaact ggggattccg gcccaagaga ctcagcttca agctcttcaa catccaggtc      960

aaagaggtta cggacaacaa tggagtcaag accatcgcca ataaccttac cagcacggtc     1020

caggtcttca cggactcaga ctatcagctc ccgtacgtgc tcgggtcggc tcacgagggc     1080

tgcctcccgc cgttcccagc ggacgttttc atgattcctc agtacgggta tctgacgctt     1140

aatgatggaa gccaggccgt gggtcgttcg tccttttact gcctggaata tttcccgtcg     1200

caaatgctaa gaacgggtaa caacttccag ttcagctacg agtttgagaa cgtacctttc     1260

catagcagct acgctcacag ccaaagcctg gaccgactaa tgaatccact catcgaccaa     1320

tacttgtact atctctcaaa gactattaac ggttctggac agaatcaaca aacgctaaaa     1380

ttcagtgtgg ccggacccag caacatggct gtccagggaa gaaactacat acctggaccc     1440

agctaccgac aacaacgtgt ctcaaccact gtgactcaaa acaacaacag cgaatttgct     1500

tggcctggag cttcttcttg ggctctcaat ggacgtaata gcttgatgaa tcctggacct     1560

gctatggcca gccacaaaga aggagaggac cgtttctttc ctttgtctgg atctttaatt     1620

tttggcaaac aaggaactgg aagagacaac gtggatgcgg acaaagtcat gataaccaac     1680

gaagaagaaa ttaaaactac taacccggta gcaacggagt cctatggaca agtggccaca     1740

aaccaccaga gtgcccaagc acaggcgcag accggctggg ttcaaaacca aggaatactt     1800

ccgggtatgg tttggcagga cagagatgtg tacctgcaag gacccatttg ggccaaaatt     1860

cctcacacgg acggcaactt tcacccttct ccgctgatgg gagggtttgg aatgaaacac     1920

ccgcctcctc agatcctcat caaaaacaca cctgtacctg cggatcctcc aacggccttc     1980

aacaaggaca agctgaactc tttcatcacc cagtattcta ctggccaagt cagcgtggag     2040

atcgagtggg agctgcagaa ggaaaacagc aagcgctgga accccgagat ccagtacacc     2100

tccaactact acaaatctac aagtgtggac tttgctgtta atacagaagg cgtgtactct     2160

gaaccccgcc ccattggcac ccgttacctc acccgtaatc tgtaa                     2205


<210> 5255
<211> 734
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5255
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Val Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Arg Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu Phe Glu 
                405                 410                 415     


Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr 
        435                 440                 445             


Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser Val Ala 
    450                 455                 460                 


Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro Gly Pro 
465                 470                 475                 480 


Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn Asn Asn 
                485                 490                 495     


Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn Gly Arg 
            500                 505                 510         


Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys Glu Gly 
        515                 520                 525             


Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly Lys Gln 
    530                 535                 540                 


Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile Thr Asn 
545                 550                 555                 560 


Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser Tyr Gly 
                565                 570                 575     


Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln Thr Gly 
            580                 585                 590         


Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp Arg 
        595                 600                 605             


Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp 
    610                 615                 620                 


Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met Lys His 
625                 630                 635                 640 


Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro 
                645                 650                 655     


Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr Gln Tyr 
            660                 665                 670         


Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu 
        675                 680                 685             


Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr 
    690                 695                 700                 


Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu Gly Val Tyr Ser 
705                 710                 715                 720 


Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 


<210> 5256
<211> 2217
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5256
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagaaag gccaacagcc cgccagaaaa agactcaatt ttggtcagac tggcgactca      540

gagtcagttc cagaccctca acctctcgga gaacctccag cagcgccctc tggtgtggga      600

cctaatacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacatcggg aggagccacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tttcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggag taccagctgc cgtacgttct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtgttca tgattcccca gtacggctac     1140

ctaacactca acaacggtag tcaggccgtg ggacgctcct ccttctactg cctggaatac     1200

tttccttcgc agatgctgag aaccggcaac aacttccagt ttacttacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcccacagc cagagcttgg accggctgat gaatcctctg     1320

attgaccagt acctgtacta cttgtctcgg actcaaacaa caggaggcac ggcaaatacg     1380

cagactctgg gcttcagcca aggtgggcct aatacaatgg ccaatcaggc aaagaactgg     1440

ctgccaggac cctgttaccg ccaacaacgc gtctcaacga caaccgggca aaacaacaat     1500

agcaactttg cctggactgc tgggaccaaa taccatctga atggaagaaa ttcattggct     1560

aatcctggca tcgctatggc aacacacaaa gacgacgagg agcgtttttt tcccagtaac     1620

gggatcctga tttttggcaa acaaaatgct gccagagaca atgcggatta cagcgatgtc     1680

atgctcacca gcgaggaaga aatcaaaacc actaaccctg tggctacaga ggaatacggt     1740

atcgtggcag ataacttgca gcagcaaaac acggctcctc aaattggaac tgtcaacagc     1800

cagggggcct tacccggtat ggtctggcag aaccgggacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccacccct ctcccctcat gggtggattc     1920

ggacttaaac atcctccgcc tcagatcctg atcaagaaca cgcctgtacc tgcggatcct     1980

ccgaccacct tcaaccagtc aaagctgaac tctttcatca cgcaatacag caccggacag     2040

gtcagcgtgg aaattgaatg ggagctgcag aaggaaaaca gcaagcgctg gaaccccgag     2100

atccagtaca cctccaacta ctacaaatct acaagtgtgg actttgctgt taatacagaa     2160

ggcgtgtact ctgaaccccg ccccattggc acccgttacc tcacccgtaa tctgtaa        2217


<210> 5257
<211> 738
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5257
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly 
    450                 455                 460                 


Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile 
    530                 535                 540                 


Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5258
<211> 2211
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5258
atggctgctg acggttatct tccagattgg ctcgaggaca acctttctga aggcattcga       60

gagtggtggg cgctgcaacc tggagcccct aaacccaagg caaatcaaca acatcaggac      120

aacgctcggg gtcttgtgct tccgggttac aaatacctcg gacccggcaa cggactcgac      180

aagggggaac ccgtcaacgc agcggacgcg gcagccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggtga caacccctac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga tcagtctcct caggaaccgg actcatcatc tggtgttggc      480

aaatcgggca aacagcctgc cagaaaaaga ctaaatttcg gtcagactgg cgactcagag      540

tcagtcccag accctcaacc tctcggagaa ccaccagcag cccccacaag tttgggatct      600

aatacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca ccagaacctg ggccctgccc acttacaaca accatctcta caagcaaatc      780

tccagccaat caggagcttc aaacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact ttaacagatt ccactgccac ttctcaccac gtgactggca gcgactcatt      900

aacaacaact ggggattccg gcccaagaaa ctcagcttca agctcttcaa catccaagtt      960

aaagaggtca cgcagaacga tggcacgacg actattgcca ataaccttac cagcacggtt     1020

caggtgttta cggactcgga gtatcagctc ccgtacgtgc tcgggtcggc gcaccaaggc     1080

tgtctcccgc cgtttccagc ggacgtcttc atggtccctc agtatggata cctcaccctg     1140

aacaacggaa gtcaagcggt gggacgctca tccttttact gcctggagta cttcccttcg     1200

cagatgctaa ggactggaaa taacttccaa ttcagctata ccttcgagga tgtacctttt     1260

cacagcagct acgctcacag ccagagtttg gatcgcttga tgaatcctct tattgatcag     1320

tatctgtact acctgaacag aacgcaagga acaacctctg gaacaaccaa ccaatcacgg     1380

ctgcttttta gccaggctgg gcctcagtct atgtctttgc aggccagaaa ttggctacct     1440

gggccctgct accggcaaca gagactttca aagactgcta acgacaacaa caacagtaac     1500

tttccttgga cagcggccag caaatatcat ctcaatggcc gcgactcgct ggtgaatcca     1560

ggaccagcta tggccagtca caaggacgat gaagaaaaat ttttccctat gcacggcaat     1620

ctaatatttg gcaaagaagg gacaacggca agtaacgcag aattagataa tgtaatgatt     1680

acggatgaag aagagattcg taccaccaat cctgtggcaa cagagcagta tggaactgtg     1740

gcaaataact tgcagagctc aaatacagct cccacgacta gaactgtcaa tgatcagggg     1800

gccttacctg gcatggtgtg gcaagatcgt gacgtgtacc ttcaaggacc tatctgggca     1860

aagattcctc acacggatgg acactttcat ccttctcctc tgatgggagg ctttggactg     1920

aaacatccgc ctcctcaaat catgatcaaa aatactccgg taccggcaaa tcctccgacg     1980

actttcagcc cggccaagtt tgcttcattt atcactcagt actccactgg acaggtcagc     2040

gtggaaattg agtgggagct acagaaagaa aacagcaaac gttggaatcc agagattcag     2100

tacacttcca actacaacaa gtctgttaat gtggacttta ctgtagacac taatggtgtt     2160

tatagtgaac ctcgccccat tggcacccgt taccttaccc gtcccctgta a              2211


<210> 5259
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5259
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Gln Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5260
<211> 2211
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5260
atggctgctg acggttatct tccagattgg ctcgaggaca acctttctga aggcattcga       60

gagtggtggg cgctgcaacc tggagcccct aaacccaagg caaatcaaca acatcaggac      120

aacgctcggg gtcttgtgct tccgggttac aaatacctcg gacccggcaa cggactcgac      180

aagggggaac ccgtcaacgc agcggacgcg gcagccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggtga caacccctac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga tcagtctcct caggaaccgg actcatcatc tggtgttggc      480

aaatcgggca aacagcctgc cagaaaaaga ctaaatttcg gtcagactgg cgactcagag      540

tcagtcccag accctcaacc tctcggagaa ccaccagcag cccccacaag tttgggatct      600

aatacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaggg tgccgatgga      660

gtgggtaatt cctcaggaaa ttggcattgc gattcccaat ggctgggcga cagagtcatc      720

accaccagca ccagaacctg ggccctgccc acttacaaca accatctcta caagcaaatc      780

tccagccaat caggagcttc aaacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact ttaacagatt ccactgccac ttctcaccac gtgactggca gcgactcatt      900

aacaacaact ggggattccg gcccaagaaa ctcagcttca agctcttcaa catccaagtt      960

aaagaggtca cgcagaacga tggcacgacg actattgcca ataaccttac cagcacggtt     1020

caagtgttta cggactcgga gtatcagctc ccgtacgtgc tcgggtcggc gcaccaaggc     1080

tgtctcccgc cgtttccagc ggacgtcttc atggtccctc agtatggata cctcaccctg     1140

aacaacggaa gtcaagcggt gggacgctca tccttttact gcctggagta cttcccttcg     1200

cagatgctaa ggactggaaa taacttccaa ttcagctata ccttcgagga tgtacctttt     1260

cacagcagct acgctcacag ccagagtttg gatcgcttga tgaatcctct tattgatcag     1320

tatctgtact acctgaacag aacgcaagga acaacctctg gaacaaccaa ccaatcacgg     1380

ctgcttttta gccaggctgg gcctcagtct atgtctttgc aggccagaaa ttggctacct     1440

gggccctgct accggcaaca gagactttca aagactgcta acgacaacaa caacagtaac     1500

tttccttgga cagcggccag caaatatcat ctcaatggcc gcgactcgct ggtgaatcca     1560

ggaccagcta tggccagtca caaggacgat gaagaaaaat ttttccctat gcacggcaat     1620

ctaatatttg gcaaagaagg gacaacggca agtaacgcag aattagataa tgtaatgatt     1680

acggatgaag aagagattcg taccaccaat cctgtggcaa cagagcagta tggaactgtg     1740

gcaaataact tgcagagctc aaatacagct cccacgacta gaactgtcaa tgatcagggg     1800

gccttacctg gcatggtgtg gcaagatcgt gacgtgtacc ttcaaggacc tatctgggca     1860

aagattcctc acacggatgg acactttcat ccttctcctc tgatgggagg ctttggactg     1920

aaacatccgc ctcctcaaat catgatcaaa aatactccgg taccggcaaa tcctccgacg     1980

actttcagcc cggccaagtt tgcttcattt atcactcagt actccactgg acaggtcagc     2040

gtggaaattg agtgggagct acagaaagaa aacagcaaac gttggaatcc agagattcag     2100

tacacttcca actacaacaa gtctgttaat gtggacttta ctgtagacac taatggtgtt     2160

tatagtgaac ctcgccccat tggcacccgt taccttaccc gtcccctgta a              2211


<210> 5261
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5261
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Gln Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5262
<211> 2211
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5262
atggctgctg acggttatct tccagattgg ctcgaggaca acctttctga aggcattcgt       60

gagtggtggg ctctgaaacc tggagtccct caacccaaag cgaaccaaca acaccaggac      120

aaccgtcggg gtcttgtgct tccgggttac aaatacctcg gacccggtaa cggactcgac      180

aaaggagagc ccgtcaacgc ggcggatgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaaga gggttctcga accttttggt ctggttgagg aaggtgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcatcggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgcacctg ggccttgccc acctacaata accacctcta caagcaaatc      780

tccagtgctt caacgggggc cagcaacgac aaccactact tcggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc catttctcac cacgtgactg gcagcgactc      900

atcaacaaca attggggatt ccggcccaag agactcaact tcaagctctt caacatccaa      960

gtcaaggagg tcacgacgaa tgatggcgtc acgaccatcg ctaataacct taccagcacg     1020

gttcaagtct tctcggactc ggagtaccag cttccgtacg tcctcggctc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgtg ttcatgattc cgcaatacgg ctacctgacg     1140

ctcaacaatg gcagccaagc cgtgggacgt tcatcctttt actgcctgga atatttccct     1200

tctcagatgc tgagaacggg caacaacttt accttcagct acacctttga ggaagtgcct     1260

ttccacagca gctacgcgca cagccagagc ctggaccggc tgatgaatcc tctcatcgac     1320

caatacctgt attacctgaa cagaactcaa aatcagtccg gaagtgccca aaacaaggac     1380

ttgctgttta gccgtgggtc tccagctggc atgtctgttc agcccaaaaa ctggctacct     1440

ggaccctgtt atcggcagca gcgcgtttct aaaacaaaaa cagacaacaa caacagcaat     1500

tttacctgga ctggtgcttc aaaatataac ctcaatgggc gtgaatccat catcaaccct     1560

ggcactgcta tggcctcaca caaagacgac gaagacaagt tctttcccat gagcggtgtc     1620

atgatttttg gaaaagagag cgccggagct tcaaacactg cattggacaa tgtcatgatt     1680

acagacgaag aggaaattaa agccactaac cctgtggcca ccgaaagatt tgggaccgtg     1740

gcagtcaatt tccagagcag cagcacagac cctgcgaccg gagatgtgca tgttatggga     1800

gccttacctg gaatggtgtg gcaagacaga gacgtatacc tgcagggtcc tatttgggcc     1860

aaaattcctc acacggatgg acactttcac ccgtctcctc tcatgggcgg ctttggactt     1920

aagcacccgc ctcctcagat cctcatcaaa aacacgcctg ttcctgcgaa tcctccggca     1980

gagttttcgg ctacaaagtt tgcttcattc atcacccagt attccacagg acaagtgagc     2040

gtggagattg aatgggagct gcagaaagaa aacagcaaac gctggaatcc cgaagtgcag     2100

tatacatcta actatgcaaa atctgccaac gttgatttca ctgtggacaa caatggactt     2160

tatactgagc ctcgccccat tggcacccgt tacctcaccc gtcccctgta a              2211


<210> 5263
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5263
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Val Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Arg Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5264
<211> 2217
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5264
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggatgca acggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagaaag gccaacagcc cgccagaaaa agactcaatt ttggtcagac tggcgactca      540

gagtcagttc cagaccctca acctctcgga gaaccaccag cagcccccac aagtttggga      600

tctaatacaa tggcttcagg cggtggcgca ccaatggcag acaataacga gggtgccgat      660

ggagtgggta attcctcagg aaattggcat tgcgattccc aatggctggg cgacagagtc      720

atcaccacca gcacccgcac ctgggccttg cccacctaca ataaccacct ctacaagcaa      780

atctccagtg cttcaacggg ggccagcaac gacaaccact acttcggcta cagcaccccc      840

tgggggtatt ttgactttaa ccgcttccac tgccacttct cgccaagaga ctggcaaaga      900

ctcatcaaca acaattgggg attccggccc aagagactca acttcaaact cttcaacatc      960

caagtcaagg aggtcacgac gaatgatggc gtcacgacca tcgccaataa cctcaccagc     1020

accatccagg tgtttacgga ctcggagtac cagctgccgt acgttctcgg ctctgcccac     1080

cagggctgcc tgcctccgtt cccggcggac gtgttcatga ttccccagta tggatacctc     1140

accctgaaca acggaagtca agcggtggga cgctcatcct tttactgcct ggagtacttc     1200

ccttcgcaga tgctaaggac tggaaataac ttccaattca gctatacctt cgaggatgta     1260

ccttttcaca gcagctacgc tcacagccag agtttggatc gcttgatgaa tcctcttatt     1320

gatcagtatc tgtactacct gaacagaacg caaggaacaa cctctggaac aaccaaccaa     1380

tcacggctgc tttttagcca ggctgggcct cagtctatgt ctttgcaggc cagaaattgg     1440

ctacctgggc cctgctaccg gcaacagaga ctttcaaaga ctgctaacga caacaacaac     1500

agtaactttc cttggacagc agccagcaaa tatcatctca atggccgcga ctcgctggtg     1560

aatccaggac cagctatggc cagtcacaag gacgatgaag aaaaattttt ccctatgcac     1620

ggcaatctaa tatttggcaa agaagggaca acggcaagta acgcagaatt agataatgta     1680

atgattacgg atgaagaaga gattcgtacc accaatcctg tggcaacaga gcagtatgga     1740

actgtggcaa ataacttgca gagctcaaat acagctccca cgactagaac tgtcaatgat     1800

cagggggcct tacctggcat ggtgtggcaa gatcgtgacg tgtaccttca ggggcccatc     1860

tgggcaaaga ttccacacac ggacggacat tttcacccct ctcccctcat gggtggattc     1920

ggacttaaac accctcctcc gcagattctc atcaagaaca ccccggtacc tgcgaatcct     1980

tcgaccacct tcagtgcggc aaagtttgct tccttcatca cacagtactc cacgggacag     2040

gtcagcgtgg agatcgagtg ggagctgcag aaggaaaaca gcaagcgctg gaacccggag     2100

atccagtaca cttccaacta ttacaagtct aataatgttg aatttgctgt taatactgaa     2160

ggtgtatata gtgaaccccg ccccattggc accagatacc tgactcgtaa tctgtaa        2217


<210> 5265
<211> 738
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5265
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Thr Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn 
            260                 265                 270         


His Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn 
        435                 440                 445             


Arg Thr Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn 
                485                 490                 495     


Asp Asn Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser 
        515                 520                 525             


His Lys Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile 
    530                 535                 540                 


Phe Gly Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val 
545                 550                 555                 560 


Met Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala 
            580                 585                 590         


Pro Thr Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asn Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5266
<211> 2208
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5266
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg acttgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggtgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcattggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtccccg acccacaacc tctcggagaa cctccagcaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgatt tcaacagatt ccactgccac ttttcaccac gtgactggca gcgactcatc      900

aacaacaatt ggggattccg gcccaagaga ctcagcttca agctcttcaa catccaggtc      960

aaggaggtca cgcagaatga aggcaccaag accatcgcca ataaccttac cagcacggtt     1020

caagtgttta cggactcgga gtatcagctc ccgtacgtgc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gaccgtctca tgaatcctct gattgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggactatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccg tctccgctga tgggcggctt tggcctgaaa     1920

catcctccgc ctcagatcct gatcaagaac acgcctgtac ctgcggatcc tccgaccacc     1980

ttcaaccagt caaagctgaa ctctttcatc actcagtatt ctactggcca agtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaagcgct ggaaccccga gatccagtac     2100

acctccaact actacaaatc tacaagtgtg gactttgctg ttaatacaga aggcgtgtac     2160

tctgaacccc gccccattgg cacccgttac ctcacccgta atctgtaa                  2208


<210> 5267
<211> 735
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5267
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Tyr Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp 
                645                 650                 655     


Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 5268
<211> 2214
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5268
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggatgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaaga gggttctcga accttttggt ctggttgagg aaggtgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcattggc      480

aagacaggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc      840

tgggggtatt ttgatttcaa cagattccac tgccatttct caccacgtga ctggcagcga      900

ctcatcaaca acaattgggg attccggccc aagagactca acttcaagct cttcaacatc      960

caggtcaagg aggtcacgca gaatgaaggc accaagacca tcgccaataa cctcaccagc     1020

accatccagg tgtttacgga ctcggagtac cagctgccgt acgttctcgg ctctgcccac     1080

cagggctgcc tgcctccgtt cccggcggac gtgttcatga ttccccagta cggctaccta     1140

acactcaaca acggtagtca ggccgtggga cgctcctcct tctactgcct ggaatacttt     1200

ccttcgcaga tgctgagaac cggcaacaac ttccagttta cttacacctt cgaggacgtg     1260

cctttccaca gcagctacgc ccacagccag agcttggacc ggctgatgaa tcctctgatt     1320

gaccagtacc tgtactactt gtctcggact caaacaacag gaggcacgac aaatacgcag     1380

actctgggct tcagccaagg tgggcctaat acaatggcca atcaggcaaa gaactggctg     1440

ccaggaccct gttaccgcca gcagcgagta tcaaagacat ttgcggataa caacaacagt     1500

gaatactcgt ggactggagc taccaagtac cacctcaatg gcagagactc tctggtgaat     1560

ccgggcccgg ccatggcaag ccacaaggac gatgaagaaa agttttttcc tcagagcggg     1620

gttctcatct ttgggaagca aggctcagag aaaacaaatg tggacattga aaaggtcatg     1680

attacagacg aagaggaaat caggacaacc aatcccgtgg ctacggagca gtatggttct     1740

gtatctacca acctccagag aggcaacaga caagcagcta ccgcagatgt caacacacaa     1800

ggcgttcttc caggcatggt ctggcaggac agagatgtgt accttcaggg gcccatctgg     1860

gcaaagattc cacacacgga cggacatttt cacccctctc ccctcatggg tggattcgga     1920

cttaaacacc ctccgcctca gatcctgatc aagaacacgc ctgtacccgc ggatcctccg     1980

accaccttca accagtcaaa gctgaactct ttcatcaccc agtattctac tggccaagtc     2040

agcgtggaga tcgagtggga gctgcagaag gaaaacagca agcgctggaa ccccgagatc     2100

cagtacacct ccaactacta caaatctaca agtgtggact ttgctgttaa tacagaaggc     2160

gtgtactctg aaccccgccc cattggcacc cgttacctca cccgtaatct gtaa           2214


<210> 5269
<211> 737
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5269
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Gly Thr Thr Asn Thr Gln Thr Leu Gly Phe 
    450                 455                 460                 


Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Phe Ala Asp 
                485                 490                 495     


Asn Asn Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu 
            500                 505                 510         


Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His 
        515                 520                 525             


Lys Asp Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe 
    530                 535                 540                 


Gly Lys Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met 
545                 550                 555                 560 


Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Gln Tyr Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala 
            580                 585                 590         


Ala Thr Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5270
<211> 2217
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5270
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggatgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagaaag gccaacagcc cgccagaaaa agactcaatt ttggtcagac tggcgactca      540

gagtcagttc cagaccctca acctctcgga gaaccaccag cagcccccac aagtttggga      600

tctaatacaa tggcttcagg cggtggcgca ccaatggcag acaataacga gggtgccgat      660

ggagtgggta attcctcagg aaattggcat tgcgattccc aatggctggg cgacagagtc      720

atcaccacca gcacccgcac ctgggccttg cccacctaca ataaccacct ctacaagcaa      780

atctccagtg cttcaacggg ggccagcaac gacaaccact acttcggcta cagcaccccc      840

tgggggtatt ttgactttaa ccgcttccac tgccacttct cgccaagaga ctggcaaaga      900

ctcatcaaca acaattgggg attccggccc aagagactca acttcaaact cttcaacatc      960

caagtcaagg aggtcacgac gaatgatggc gtcacgacca tcgccaataa cctcaccagc     1020

accatccagg tgtttacgga ctcggagtac cagctgccgt acgttctcgg ctctgcccac     1080

cagggctgcc tgcctccgtt cccggcggac gtgttcatga ttccccagta tggatacctc     1140

accctgaaca acggaagtca agcggtggga cgctcatcct tttactgcct ggagtacttc     1200

ccttcgcaga tgctaaggac tggaaataac ttccaattca gctatacctt cgaggatgta     1260

ccttttcaca gcagctacgc tcacagccag agtttggatc gcttgatgaa tcctcttatt     1320

gatcagtatc tgtactacct gaacagaacg caaggaacaa cctctggaac aaccaaccaa     1380

tcacggctgc tttttagcca ggctgggcct cagtctatgt ctttgcaggc cagaaattgg     1440

ctacctgggc cctgctaccg gcaacagaga ctttcaaaga ctgctaacga caacaacaac     1500

agtaactttc cttggacagc agccagcaaa tatcatctca atggccgcga ctcgctggtg     1560

aatccaggac cagctatggc cagtcacaag gacgatgaag aaaaattttt ccctatgcac     1620

ggcaatctaa tatttggcaa agaagggaca acggcaagta acgcagaatt agataatgta     1680

atgattacgg atgaagaaga gattcgtacc accaatcctg tggcaacaga gcagtatgga     1740

actgtggcaa ataacttgca gagctcaaat acagctccca cgactagaac tgtcaatgat     1800

cagggggcct tacctggcat ggtgtggcaa gatcgtgacg tgtaccttca ggggcccatc     1860

tgggcaaaga ttccacacac ggacggacat tttcacccct ctcccctcat gggtggattc     1920

ggacttaaac accctcctcc gcagattctc atcaagaaca ccccggtacc tgcgaatcct     1980

tcgaccacct tcagtgcggc aaagtttgct tccttcatca cacagtactc cacgggacag     2040

gtcagcgtgg agatcgagtg ggagctgcag aaggaaaaca gcaagcgctg gaacccggag     2100

atccagtaca cttccaacta ttacaagtct aataatgttg aatttgctgt taatactgaa     2160

ggtgtatata gtgaaccccg ccccattggc accagatacc tgactcgtaa tctgtaa        2217


<210> 5271
<211> 738
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5271
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn 
            260                 265                 270         


His Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn 
        435                 440                 445             


Arg Thr Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn 
                485                 490                 495     


Asp Asn Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser 
        515                 520                 525             


His Lys Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile 
    530                 535                 540                 


Phe Gly Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val 
545                 550                 555                 560 


Met Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala 
            580                 585                 590         


Pro Thr Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asn Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210> 5272
<211> 2208
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5272
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 5273
<211> 735
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5273
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 5274
<211> 2208
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5274
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgcc gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcagctaa aacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctccgc gggtattggc      480

aaatcgggtg cacagcccgc caaaaagaga ctcaatttcg gtcagactgg cgactcagag      540

tcagtcccag accctcaacc tctcggagaa ccaccagcag cccccacaag tttgggatct      600

aatacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgcacctg ggccttgccc acctacagca accatctcta caagcaaatc      780

tccagccaat caggagcttc aaacgacaac gactactttg gctacagcac cccttggggg      840

tattttgatt tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgagg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210> 5275
<211> 735
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5275
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Ser Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn Asp Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Glu Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 5276
<211> 2208
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5276
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttc      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaaga gggttctcga accttttggt ctggttgagg aaggtgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcattggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaattttg gtcagactgg cgactcagag      540

tcagtcccag accctcaacc tctcggagaa ccaccagcag cccccacaag tttgggatct      600

aatacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcttc aaacgacaac cactactttg gctacagcac cccttggggg      840

tattttgact ttaacagatt ccactgccac ttttcaccac gtgactggca gcgactcatt      900

aacaacaact ggggattccg gcccaagaaa ctcaacttca agctctttaa catccaggtc      960

aaggaggtca cgcagaatga aggcaccaag accatcgcca ataacctcac cagcaccatc     1020

caggtgttta cggactcgga gtaccagctg ccgtacgttc tcggctctgc ccaccagggc     1080

tgcctgcctc cgttcccggc ggacgtgttc atgattcccc agtacggcta cctaacactc     1140

aacaacggta gtcaggccgt gggacgctcc tccttctact gcctggaata ctttccttcg     1200

cagatgctga gaaccggcaa caacttccag tttacttaca ccttcgagga cgtgcctttc     1260

cacagcagct acgcccacag ccagagcttg gaccggctga tgaatcctct gattgaccag     1320

tacctgtatt acttgtctcg gactcaaaca acaggaggca cgacaaatac gcagactctg     1380

ggcttcagcc aaggtgggcc taatacaatg gccaatcagg caaagaactg gctgcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt tatgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acagggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc agggtcccat ttgggccaaa     1860

attcctcaca cagatggaca ctttcacccg tcccctctta tgggcggctt tggactcaag     1920

aacccgcctc ctcagatcct catcaaaaac acgcctgttc ctgcgaatcc tccggcagag     1980

ttttcagcta caaagtttgc ttcattcatc acccaatact ccacaggaca agtgagtgtg     2040

gaaattgaat gggagctgca gaaagaaaac agcaagcgct ggaatcccga agtgcagtac     2100

acatccaatt atgcaaaatc tgccaacgtt gattttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctcacccgta atctgtaa                  2208


<210> 5277
<211> 735
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5277
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Gln Thr Thr Gly Gly Thr Thr Asn Thr Gln Thr Leu Gly Phe Ser Gln 
    450                 455                 460                 


Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 5278
<211> 2214
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5278
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acttgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggatgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aagcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaaga gggttctcga accttttggt ctggttgagg aaggtgctaa gacggctcct      420

ggaaagaaac gtccggtaga gcagtcgcca caagagccag actcctcctc gggcattggc      480

aagacaggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc      840

tgggggtatt ttgatttcaa cagattccac tgccatttct caccacgtga ctggcagcga      900

ctcatcaaca acaattgggg attccggccc aagagactca acttcaagct cttcaacatc      960

caggtcaagg aggtcacgca gaatgaaggc accaagacca tcgccaataa cctcaccagc     1020

accatccagg tgtttacgga ctcggagtac cagctgccgt acgttctcgg ctctgcccac     1080

cagggctgcc tgcctccgtt cccggcggac gtgttcatga ttccccagta cggctaccta     1140

acactcaaca acggtagtca ggccgtggga cgctcctcct tctactgcct ggaatacttt     1200

ccttcgcaga tgctgagaac cggcaacaac ttccagttta cttacacctt cgaggacgtg     1260

cctttccaca gcagctacgc ccacagccag agcttggacc ggctgatgaa tcctctgatt     1320

gaccagtacc tgtactactt gtctcggact caaacaacag gaggcacgac aaatacgcag     1380

actctgggct tcagccaagg tgggcctaat acaatggcca atcaggcaaa gaactggctg     1440

ccaggaccct gttaccgcca gcagcgagta tcaaagacat ttgcggataa caacaacagt     1500

gaatactcgt ggactggagc taccaagtac cacctcaatg gcagagactc tctggtgaat     1560

ccgggcccgg ccatggcaag ccacaaggac gatgaagaaa agttttttcc tcagagcggg     1620

gttctcatct ttgggaagca aggctcagag aaaacaaatg tggacattga aaaggtcatg     1680

attacagacg aagaggaaat caggacaacc aatcccgtgg ctacggagca gtatggttct     1740

gtatctacca acctccagag aggcaacaga caagcagcta ccgcagatgt caacacacaa     1800

ggcgttcttc caggcatggt ctggcaggac agagatgtgt accttcaggg gcccatctgg     1860

gcaaagattc cacacacgga cggacatttt cacccctctc ccctcatggg tggattcgga     1920

cttaaacacc ctccgcctca gatcctgatc aagaacacgc ctgtacccgc ggatcctccg     1980

accaccttca accagtcaaa gctgaactct ttcatcaccc agtattctac tggccaagtc     2040

agcgtggaga tcgagtggga gctgcagaag gaaaacagca agcgctggaa ccccgagatc     2100

cagtacacct ccaactacta caaatctaca agtgtggact ttgctgttaa tacagaaggc     2160

gtgtactctg aaccccgccc cattggcacc cgttacctca cccgtaatct gtaa           2214


<210> 5279
<211> 737
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5279
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Gly Thr Thr Asn Thr Gln Thr Leu Gly Phe 
    450                 455                 460                 


Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Phe Ala Asp 
                485                 490                 495     


Asn Asn Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu 
            500                 505                 510         


Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His 
        515                 520                 525             


Lys Asp Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe 
    530                 535                 540                 


Gly Lys Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met 
545                 550                 555                 560 


Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Gln Tyr Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala 
            580                 585                 590         


Ala Thr Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210> 5280
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5280
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Pro Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Leu Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Val 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Thr Gly Gly Thr Gln Thr Leu Ala Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Ser Ser Met Ala Asn Gln Ala Arg Asn Trp Val Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Asn Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Ala Lys Phe Lys Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Met Asn Pro Gly Val Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Ala Gly Asn Asp Gly Val Asp Tyr Ser Gln Val Leu Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ala Val Ala Ile Asn Asn Gln Ala Ala Asn Thr Gln Ala Gln 
            580                 585                 590         


Thr Gly Leu Val His Asn Gln Gly Val Ile Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Leu Thr Phe Asn Gln Ala Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 5281
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5281
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Pro Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Leu Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Val 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Thr Gly Gly Thr Gln Thr Leu Ala Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Ser Ser Met Ala Asn Gln Ala Arg Asn Trp Val Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Asn Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Ala Lys Phe Lys Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Met Asn Pro Gly Val Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Ala Gly Asn Asp Gly Val Asp Tyr Ser Gln Val Leu Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ala Val Ala Ile Asn Asn Gln Arg Ala Asn Thr Gln Ala Gln 
            580                 585                 590         


Thr Gly Leu Val His Asn Gln Gly Val Ile Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Leu Thr Phe Asn Gln Ala Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 5282
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5282
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Pro Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Leu Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Val 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Thr Gly Gly Thr Gln Thr Leu Ala Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Ser Ser Met Ala Asn Gln Ala Arg Asn Trp Val Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Asn Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Ala Lys Phe Lys Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Met Asn Pro Gly Val Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Ala Phe Phe Pro Ser Ser Gly Val Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Ala Gly Asn Asp Gly Val Asp Tyr Ser Gln Val Leu Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ala Val Ala Ile Asn Asn Gln Ala Ala Asn Thr Gln Ala Gln 
            580                 585                 590         


Thr Gly Leu Val His Asn Gln Gly Val Ile Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Leu Thr Phe Asn Gln Ala Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210> 5283
<211> 538
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5283
Met Arg Ala Ala Ala Gly Gly Asn Gly Gly Asp Ala Gly Gln Gly Ala 
1               5                   10                  15      


Glu Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 
            20                  25                  30          


Ser Glu Ser His Val Thr Thr Thr Ser Thr Arg Thr Trp Val Leu Pro 
        35                  40                  45              


Thr Tyr Asn Asn His Leu Tyr Leu Arg Leu Gly Ser Ser Asn Ala Ser 
    50                  55                  60                  


Asp Thr Phe Asn Gly Phe Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
65                  70                  75                  80  


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
                85                  90                  95      


Asn His Trp Gly Leu Arg Pro Lys Ser Met Gln Val Arg Ile Phe Asn 
            100                 105                 110         


Ile Gln Val Lys Glu Val Thr Thr Ser Asn Gly Glu Thr Thr Val Ser 
        115                 120                 125             


Asn Asn Leu Thr Ser Thr Val Gln Ile Phe Ala Asp Ser Thr Tyr Glu 
    130                 135                 140                 


Leu Pro Tyr Val Met Asp Ala Gly Gln Glu Gly Ser Leu Pro Pro Phe 
145                 150                 155                 160 


Pro Asn Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Cys Gly Leu Val 
                165                 170                 175     


Thr Gly Gly Ser Ser Gln Asn Gln Thr Asp Arg Asn Ala Phe Tyr Cys 
            180                 185                 190         


Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu 
        195                 200                 205             


Met Val Tyr Lys Phe Glu Asn Val Pro Phe His Ser Met Tyr Ala His 
    210                 215                 220                 


Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Leu Asp Gln Tyr Leu 
225                 230                 235                 240 


Trp Glu Leu Gln Ser Thr Thr Ser Gly Gly Thr Leu Asn Gln Gly Asn 
                245                 250                 255     


Ser Ala Thr Asn Phe Ala Lys Leu Thr Lys Thr Asn Phe Ser Gly Tyr 
            260                 265                 270         


Arg Lys Asn Trp Leu Pro Gly Pro Met Met Lys Gln Gln Arg Phe Ser 
        275                 280                 285             


Lys Thr Ala Ser Gln Asn Tyr Lys Ile Pro Gln Gly Arg Asn Asn Ser 
    290                 295                 300                 


Leu Leu His Tyr Glu Thr Arg Thr Thr Leu Asp Gly Arg Trp Ser Asn 
305                 310                 315                 320 


Phe Ala Pro Gly Thr Ala Met Ala Thr Ala Ala Asn Asp Ala Thr Asp 
                325                 330                 335     


Phe Ser Gln Ala Gln Leu Ile Phe Ala Gly Pro Asn Ile Thr Gly Asn 
            340                 345                 350         


Thr Thr Thr Asp Ala Asn Asn Leu Met Phe Thr Ser Glu Asp Glu Leu 
        355                 360                 365             


Arg Ala Thr Asn Pro Arg Asp Thr Asp Leu Phe Gly His Leu Ala Thr 
    370                 375                 380                 


Asn Gln Gln Asn Ala Thr Thr Val Pro Thr Val Asp Asp Val Asp Gly 
385                 390                 395                 400 


Val Gly Val Tyr Pro Gly Met Val Trp Gln Asp Arg Asp Ile Tyr Tyr 
                405                 410                 415     


Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His 
            420                 425                 430         


Pro Ser Pro Leu Ile Gly Gly Phe Gly Leu Lys Ser Pro Pro Pro Gln 
        435                 440                 445             


Ile Phe Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Ala Thr Thr Phe 
    450                 455                 460                 


Ser Pro Ala Arg Ile Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln 
465                 470                 475                 480 


Val Ala Val Lys Ile Glu Trp Glu Ile Gln Lys Glu Arg Ser Lys Arg 
                485                 490                 495     


Trp Asn Pro Glu Val Gln Phe Thr Ser Asn Tyr Gly Ala Gln Asp Ser 
            500                 505                 510         


Leu Leu Trp Ala Pro Asp Asn Ala Gly Ala Tyr Lys Glu Pro Arg Ala 
        515                 520                 525             


Ile Gly Ser Arg Tyr Leu Thr Asn His Leu 
    530                 535             


<210> 5284
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5284
Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Ser Ile Gly Asp 
1               5                   10                  15      


Gly Phe Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Ala Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Asp Pro Val 
    50                  55                  60                  


Asn Phe Ala Asp Glu Val Ala Arg Glu His Asp Leu Ser Tyr Gln Lys 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Ser Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro Leu 
        115                 120                 125             


Gly Leu Val Glu Thr Pro Asp Lys Thr Ala Pro Ala Ala Lys Lys Arg 
    130                 135                 140                 


Pro Leu Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Lys Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Asp Asp Glu 
                165                 170                 175     


Pro Gly Ala Gly Asp Gly Pro Pro Pro Glu Gly Pro Ser Ser Gly Ala 
            180                 185                 190         


Met Ser Thr Glu Thr Glu Met Arg Ala Ala Ala Gly Gly Asn Gly Gly 
        195                 200                 205             


Asp Ala Gly Gln Gly Ala Glu Gly Val Gly Asn Ala Ser Gly Asp Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Ser Glu Ser His Val Thr Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Val Leu Pro Thr Tyr Asn Asn His Leu Tyr Leu Arg Leu 
                245                 250                 255     


Gly Ser Ser Asn Ala Ser Asp Thr Phe Asn Gly Phe Ser Thr Pro Trp 
            260                 265                 270         


Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp 
        275                 280                 285             


Trp Gln Arg Leu Ile Asn Asn His Trp Gly Leu Arg Pro Lys Ser Met 
    290                 295                 300                 


Gln Val Arg Ile Phe Asn Ile Gln Val Lys Glu Val Thr Thr Ser Asn 
305                 310                 315                 320 


Gly Glu Thr Thr Val Ser Asn Asn Leu Thr Ser Thr Val His Ile Phe 
                325                 330                 335     


Ala Asp Ser Thr Tyr Glu Leu Pro Tyr Val Met Asp Ala Gly Gln Glu 
            340                 345                 350         


Gly Ser Leu Pro Pro Phe Pro Asn Asp Val Phe Met Val Pro Gln Tyr 
        355                 360                 365             


Gly Tyr Cys Gly Leu Val Thr Gly Gly Ser Ser Gln Asn Gln Thr Asp 
    370                 375                 380                 


Arg Asn Ala Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Met Val Tyr Lys Phe Glu Asn Val Pro Phe 
                405                 410                 415     


His Ser Met Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Leu Asp Gln Tyr Leu Trp Glu Leu Gln Ser Thr Thr Ser Gly Gly 
        435                 440                 445             


Thr Leu Asn Gln Gly Asn Ser Ala Thr Asn Phe Ala Lys Leu Thr Asn 
    450                 455                 460                 


Lys Asn Phe Ser Gly Tyr Arg Lys Asn Trp Leu Pro Gly Pro Met Met 
465                 470                 475                 480 


Lys Gln Gln Arg Phe Ser Lys Thr Ala Ser Gln Asn Tyr Lys Ile Pro 
                485                 490                 495     


Gln Gly Gly Asn Asn Ser Leu Leu His Tyr Glu Thr Arg Thr Thr Leu 
            500                 505                 510         


Asp Arg Arg Trp Ser Asn Phe Ala Pro Gly Thr Ala Met Ala Thr Ala 
        515                 520                 525             


Ala Asn Asp Ala Thr Asp Phe Ser Gln Ala Gln Leu Ile Phe Ala Gly 
    530                 535                 540                 


Pro Asn Ile Thr Gly Asn Thr Thr Thr Asp Ala Asn Asn Leu Met Phe 
545                 550                 555                 560 


Thr Ser Glu Asp Glu Leu Arg Ala Thr Asn Pro Arg Asp Thr Asp Leu 
                565                 570                 575     


Phe Gly His Leu Ala Thr Asn Gln Gln Asn Ala Thr Thr Val Pro Thr 
            580                 585                 590         


Val Asp Asp Val Asp Gly Val Gly Val Tyr Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Ile Tyr Tyr Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Ile Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Ser Pro Pro Pro Gln Ile Phe Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Ala Thr Thr Phe Ser Pro Ala Arg Ile Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ala Val Lys Ile Glu Trp Glu Ile Gln 
        675                 680                 685             


Lys Glu Arg Ser Lys Arg Trp Asn Pro Glu Val Gln Phe Thr Ser Asn 
    690                 695                 700                 


Tyr Gly Ala Gln Asp Ser Leu Leu Trp Ala Pro Asp Asn Ala Gly Ala 
705                 710                 715                 720 


Tyr Lys Glu Pro Arg Ala Ile Gly Ser Arg Tyr Leu Thr Asn His Leu 
                725                 730                 735     


<210> 5285
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5285
Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Ser Ile Gly Asp 
1               5                   10                  15      


Gly Phe Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Ala Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Asp Pro Val 
    50                  55                  60                  


Asn Phe Ala Asp Glu Val Ala Arg Glu His Asp Leu Ser Tyr Gln Lys 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Ser Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro Leu 
        115                 120                 125             


Gly Leu Val Glu Thr Pro Asp Lys Thr Ala Pro Ala Ala Lys Lys Arg 
    130                 135                 140                 


Pro Leu Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Lys Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Asp Asp Glu 
                165                 170                 175     


Pro Gly Ala Gly Asp Gly Pro Pro Pro Glu Gly Pro Ser Ser Gly Ala 
            180                 185                 190         


Met Ser Thr Glu Thr Glu Met Arg Ala Ala Ala Gly Gly Asn Gly Gly 
        195                 200                 205             


Asp Ala Gly Gln Gly Ala Glu Gly Val Gly Asn Ala Ser Gly Asp Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Ser Glu Ser His Val Thr Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Val Leu Pro Thr Tyr Asn Asn His Leu Tyr Leu Arg Leu 
                245                 250                 255     


Gly Ser Ser Asn Ala Ser Asp Thr Phe Asn Gly Phe Ser Thr Pro Trp 
            260                 265                 270         


Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp 
        275                 280                 285             


Trp Gln Arg Leu Ile Asn Asn His Trp Gly Leu Arg Pro Lys Ser Met 
    290                 295                 300                 


Gln Val Arg Ile Phe Asn Ile Gln Val Lys Glu Val Thr Thr Ser Asn 
305                 310                 315                 320 


Gly Glu Thr Thr Val Ser Asn Asn Leu Thr Ser Thr Val Gln Ile Phe 
                325                 330                 335     


Ala Asp Ser Thr Tyr Glu Leu Pro Tyr Val Met Asp Ala Gly Gln Glu 
            340                 345                 350         


Gly Ser Leu Pro Pro Phe Pro Asn Asp Val Phe Met Val Pro Gln Tyr 
        355                 360                 365             


Gly Tyr Cys Gly Leu Val Thr Gly Gly Ser Ser Gln Asn Gln Thr Asp 
    370                 375                 380                 


Arg Asn Ala Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Met Val Tyr Lys Phe Glu Asn Val Pro Phe 
                405                 410                 415     


His Ser Met Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Leu Asp Gln Tyr Leu Trp Glu Leu Gln Ser Thr Thr Ser Gly Gly 
        435                 440                 445             


Thr Leu Asn Gln Gly Asn Ser Ala Thr Asn Phe Ala Lys Leu Thr Lys 
    450                 455                 460                 


Thr Asn Phe Ser Gly Tyr Arg Lys Asn Trp Leu Pro Gly Pro Met Met 
465                 470                 475                 480 


Lys Gln Gln Arg Phe Ser Lys Thr Ala Ser Gln Asn Tyr Lys Ile Pro 
                485                 490                 495     


Gln Gly Arg Asn Asn Ser Leu Leu His Tyr Glu Thr Arg Thr Thr Leu 
            500                 505                 510         


Asp Gly Arg Trp Ser Asn Phe Ala Pro Gly Thr Ala Met Ala Thr Ala 
        515                 520                 525             


Ala Asn Asp Ala Thr Asp Phe Ser Gln Ala Gln Leu Ile Phe Ala Gly 
    530                 535                 540                 


Pro Asn Ile Thr Gly Asn Thr Thr Thr Asp Ala Asn Asn Leu Met Phe 
545                 550                 555                 560 


Thr Ser Glu Asp Glu Leu Arg Ala Thr Asn Pro Arg Asp Thr Asp Leu 
                565                 570                 575     


Phe Gly His Leu Ala Thr Asn Gln Gln Asn Ala Thr Thr Val Pro Thr 
            580                 585                 590         


Val Asp Asp Val Asp Gly Val Gly Val Tyr Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Ile Tyr Tyr Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Ile Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Ser Pro Pro Pro Gln Ile Phe Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Ala Thr Thr Phe Ser Pro Ala Arg Ile Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ala Val Lys Ile Glu Trp Glu Ile Gln 
        675                 680                 685             


Lys Glu Arg Ser Lys Arg Trp Asn Pro Glu Val Gln Phe Thr Ser Asn 
    690                 695                 700                 


Tyr Gly Ala Gln Asp Ser Leu Leu Trp Ala Pro Asp Asn Ala Gly Ala 
705                 710                 715                 720 


Tyr Lys Glu Pro Arg Ala Ile Gly Ser Arg Tyr Leu Thr Asn His Leu 
                725                 730                 735     


<210> 5286
<211> 2214
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5286
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctcctc gggcatcggc      480

aagacaggcc agcagcccgc taaaaagaga ctcaatttcg gtcagactgg cgacacagag      540

tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca gtggcagaca ataacgaagg tgccgatgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacggga catcgggagg agccaccaac gacaacacct acttcggcta cagcaccccc      840

tgggggtatt ttgactttaa cagattccac tgccactttt caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggccc aagagactca gcttcaagct cttcaacatc      960

caggtcaagg aggtcacgca gaatgaaggc accaagacca tcgccaataa ccttaccagc     1020

acggtccagg tcttcacgga ctcggagtac cagctgccgt acgttctcgg ctctgcccac     1080

cagggctgcc tgcctccgtt cccggcggac gtgttcatga ttccccagta cggctaccta     1140

acactcaaca acggtagtca ggccgtggga cgctcctcct tctactgcct ggaatacttt     1200

ccttcgcaga tgctgagaac cggcaacaac ttccagttta cttacacctt cgaggacgtg     1260

cctttccaca gcagctacgc ccacagccag agcttggacc ggctgatgaa tcctctgatt     1320

gaccagtacc tgtactactt gtctcggact caaacaacag gaggcacggc aaatacgcag     1380

actctgggct tcagccaagg tgggcctaat acaatggcca atcaggcaaa gaactggctg     1440

ccaggaccct gttaccgcca acaacgcgtc tcaacgacaa ccgggcaaaa caacaatagc     1500

aactttgcct ggactgctgg gaccaaatac catctgaatg gaagaaattc attggctaat     1560

cctggcatcg ctatggcaac acacaaagac gacaaggagc gtttttttcc cagtaacggg     1620

atcctgattt ttggcaaaca aaatgctgcc agagacaatg cggattacag cgatgtcatg     1680

ctcaccagcg aggaagaaat caaaaccact aaccctgtgg ctacagagga atacggtatc     1740

gtggcagata acttgcagca gcaaaacacg gctcctcaaa ttggaactgt caacagccag     1800

ggggccttac ccggtatggt ttggcagaac cgggacgtgt acctgcaggg tcccatctgg     1860

gccaagattc ctcacacgga cggcaacttc cacccgtctc cgctgatggg cggctttggc     1920

ctgaaacatc ctccgcctca gatcctgatc aagaacacgc ctgtacctgc ggatcctccg     1980

accaccttca accagtcaaa gctgaactct ttcatcacgc aatacagcac cggacaggtc     2040

agcgtggaaa ttgaatggga gctgcagaag gaaaacagca agcgctggaa ccccgagatc     2100

cagtacacct ccaactacta caaatctaca agtgtggact ttgctgttaa tacagaaggc     2160

gtgtactctg aaccccaccc cattggcacc cgttacctca cccgtcccct gtaa           2214


<210> 5287
<211> 737
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5287
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly Phe 
    450                 455                 460                 


Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly Gln 
                485                 490                 495     


Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His Leu 
            500                 505                 510         


Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr His 
        515                 520                 525             


Lys Asp Asp Lys Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile Phe 
    530                 535                 540                 


Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val Met 
545                 550                 555                 560 


Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala Pro 
            580                 585                 590         


Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro His Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro 
                725                 730                 735     


Leu 
    


<210> 5288
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5288
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg 
        435                 440                 445             


Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly Phe Ser 
    450                 455                 460                 


Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr His Lys 
        515                 520                 525             


Asp Asp Lys Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val Met Leu 
545                 550                 555                 560 


Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala Pro Gln 
            580                 585                 590         


Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro His Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5289
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5289
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Gly Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Glu Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg 
        435                 440                 445             


Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly Phe Ser 
    450                 455                 460                 


Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr His Lys 
        515                 520                 525             


Asp Asp Lys Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val Met Leu 
545                 550                 555                 560 


Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala Pro Gln 
            580                 585                 590         


Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro His Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210> 5290
<211> 2181
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5290
atgtcttttg ttgatcaccc tccagattgg ttggaagaag ttggtgaagg tcttcgcgag       60

tttttgggcc ttgaagcggg cccaccgaaa ccaaaaccca atcagcagca tcaagatcaa      120

gcccgtggtc ttgtgctgcc tggttataac tatctcggac ccggaaacgg tctcgatcga      180

ggagagcctg tcaacagggc agacgaggtc gcgcgagagc acgacatctc gtacaacgag      240

cagcttgagg cgggagacaa cccctacctc aagtacaacc acgcggacgc cgagtttcag      300

gagaagctcg ccgacgacac atccttcggg ggaaacctcg gaaaggcagt ctttcaggcc      360

aagaaaaggg ttctcgaacc ttttggcctg gttgaagagg gtgctaagac ggcccctacc      420

ggaaagcgga tagacgacca ctttccaaaa agaaagaagg ctcggaccga agaggactcc      480

aagccttcca cctcgtcaga cgccgaagct ggacccagcg gatcccagca gctgcaaatc      540

ccagcacaac cagcctcaag tttgggagct gatacaatgt ctgcgggagg tggcggccca      600

ttgggcgaca ataaccaagg tgccgatgga gtgggcaatg cctcgggaga ttggcattgc      660

gattccacgt ggatggggga cagagtcgtc accaagtcca cccgcacctg ggtgctgccc      720

agctacaaca accaccagta ccgagagatc aaaagcggct ccgtcgacgg aagcaacgcc      780

aacgcctact ttggatacag caccccctgg gggtactttg actttaaccg cttccacagc      840

cactggagcc cccgagactg gcaaagactc atcaacaact attggggctt cagaccccgg      900

tctctcagag tcaaaatctt caacatccaa gtcaaagagg tcacggtgca ggactccacc      960

accaccatcg ccaacaacct cacctccacc gtccaagtgt ttacggacga cgactaccaa     1020

ctcccgtacg tcgtcggcaa cgggaccgag ggatgcctgc cggccttccc cccgcaggtc     1080

tttacgctgc cgcagtacgg ctacgcgacg ctgaaccgag acaacggaga caacccgaca     1140

gagcggagca gcttcttttg cctagagtac tttcccagca agatgctgag gacgggcaac     1200

aactttgagt ttacctacag ctttgaagag gtgcccttcc actgcagctt cgccccgagc     1260

cagaacctct ttaagctggc caacccgctg gtggaccagt acctgtaccg cttcgtgagc     1320

acctcggcca cgggcgccat ccagttccaa aagaacctgg cgggcagata cgccaacacc     1380

tacaaaaact ggttcccggg gcccatgggc cgaacccagg gctggaacac gagctctggg     1440

gtcagcagca ccaacagagt cagcgtcaac aacttttccg tctcaaaccg gatgaacctg     1500

gagggggcca gctaccaagt gaacccccag cccaacggga tgacaaacac gctccaaggc     1560

agcaaccgct acgcgctgga aaacaccatg atcttcaacg ctcaaaacgc cacgccggga     1620

actacctcgg tgtacccaga ggacaatcta ctgctgacca gcgagagcga gactcagccc     1680

gtcaaccggg tggcttacaa cacgggcggt cagatggcca ccaacgccca gaacgccacc     1740

acggctccca cggtcgggac ctacaacctc caggaagtgc ttcctggcag cgtatggatg     1800

gagagggacg tgtacctcca aggacccatc tgggccaaga tcccagagac gggggcgcac     1860

tttcacccct ctccggccat gggcggattc ggactcaaac acccgccgcc catgatgctc     1920

atcaaaaaca cgccggtgcc cggcaacatc accagcttct cggacgtgcc cgtcagcagc     1980

ttcatcaccc agtacagcac cgggcaggtc accgtggaga tggaatggga gctcaaaaag     2040

gaaaactcca agaggtggaa cccagagatc cagtacacca acaactacaa cgacccccag     2100

tttgtggact ttgctccaga cggctccggc gaatacagaa ccaccagagc catcggaacc     2160

cgatacctca cccgacccct t                                               2181


<210> 5291
<211> 726
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5291
Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 
    130                 135                 140                 


Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 
145                 150                 155                 160 


Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 
                165                 170                 175     


Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 
            180                 185                 190         


Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 
        195                 200                 205             


Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 
    210                 215                 220                 


Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 
225                 230                 235                 240 


Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 
                245                 250                 255     


Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 
305                 310                 315                 320 


Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 
                325                 330                 335     


Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 
            340                 345                 350         


Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Ala Thr Leu Asn Arg Asp Asn Gly Asp Asn Pro Thr Glu Arg Ser Ser 
    370                 375                 380                 


Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Glu Phe Thr Tyr Ser Phe Glu Glu Val Pro Phe His Cys Ser 
                405                 410                 415     


Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 
            420                 425                 430         


Gln Tyr Leu Tyr Arg Phe Val Ser Thr Ser Ala Thr Gly Ala Ile Gln 
        435                 440                 445             


Phe Gln Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 
    450                 455                 460                 


Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Thr Ser Ser Gly 
465                 470                 475                 480 


Ser Ser Thr Asn Arg Val Ser Val Asn Asn Phe Ser Val Ser Asn Arg 
                485                 490                 495     


Met Asn Leu Glu Gly Ala Ser Tyr Gln Val Asn Pro Gln Pro Asn Gly 
            500                 505                 510         


Met Thr Asn Thr Leu Gln Gly Ser Asn Arg Tyr Ala Leu Glu Asn Thr 
        515                 520                 525             


Met Ile Phe Asn Ala Gln Asn Ala Thr Pro Gly Thr Thr Ser Val Tyr 
    530                 535                 540                 


Pro Glu Asp Asn Leu Leu Leu Thr Ser Glu Ser Glu Thr Gln Pro Val 
545                 550                 555                 560 


Asn Arg Val Ala Tyr Asn Thr Gly Gly Gln Met Ala Thr Asn Ala Gln 
                565                 570                 575     


Asn Ala Thr Thr Ala Pro Thr Val Gly Thr Tyr Asn Leu Gln Glu Val 
            580                 585                 590         


Leu Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 
        595                 600                 605             


Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 
    610                 615                 620                 


Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 
625                 630                 635                 640 


Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 
                645                 650                 655     


Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 
            660                 665                 670         


Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 
        675                 680                 685             


Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 
    690                 695                 700                 


Pro Asp Gly Ser Gly Glu Tyr Arg Thr Thr Arg Ala Ile Gly Thr Arg 
705                 710                 715                 720 


Tyr Leu Thr Arg Pro Leu 
                725     


<210> 5292
<211> 735
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5292
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ser Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Ser Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Met Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Asp Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Asp Ser Gly Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ser Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210> 5293
<211> 1803
<212> DNA
<213> Bovine adeno-associated virus

<400> 5293
acggcgcctg cggcaaaaaa gaggcctcta gagcagagtc ctcaagagcc agactcctcg       60

agcggagttg gcaagaaagg caaacagcct gccagaaaga gactcaactt tgacgacgaa      120

cctggagccg gagacgggcc tcccccagaa ggaccatctt ccggagctat gtctactgag      180

actgaaatgc gtgcagcagc tggcggaaat ggtggcgatg cgggacaagg tgccgaggga      240

gtgggtaatg cctccggtga ttggcattgc gattccactt ggtcagagag ccacgtcacc      300

accacctcaa cccgcacctg ggtcctgccg acctacaaca accacctgta cctgcggctc      360

ggctcgagca acgccagcga caccttcaac ggattctcca ccccctgggg atactttgac      420

tttaaccgct tccactgcca cttctcgcca agagactggc aaaggctcat caacaaccac      480

tggggactgc gccccaaaag catgcaagtc cgcatcttca acatccaagt taaggaggtc      540

acgacgtcta acggggagac gaccgtatcc aacaacctca ccagcacggt ccagatcttt      600

gcggacagca cgtacgagct cccgtacgtg atggatgcag gtcaggaggg cagcttgcct      660

cctttcccca acgacgtgtt catggtgcct cagtacgggt actgcggact ggtaaccgga      720

ggcagctctc aaaaccagac agacagaaat gccttctact gtctggagta ctttcccagc      780

cagatgctga gaaccggaaa caactttgag atggtgtaca agtttgaaaa cgtgcccttc      840

cactccatgt acgctcacag ccagagcctg gataggctga tgaacccgct gctggaccag      900

tacctgtggg agctccagtc taccacctct ggaggaactc tcaaccaggg caattcagcc      960

accaactttg ccaagctgac caaaacaaac ttttctggct accgcaaaaa ctggctcccg     1020

gggcccatga tgaagcagca gagattctcc aagactgcca gtcaaaacta caagattccc     1080

cagggaagaa acaacagtct gctccattat gagaccagaa ctaccctcga cggaagatgg     1140

agcaattttg ccccgggaac ggccatggca accgcagcca acgacgccac cgacttctct     1200

caggcccagc tcatctttgc ggggcccaac atcaccggca acaccaccac agatgccaat     1260

aacctgatgt tcacttcaga agatgaactt agggccacca acccccggga cactgacctg     1320

tttggccacc tggcaaccaa ccagcaaaac gccaccaccg ttcctaccgt agacgacgtg     1380

gacggagtcg gcgtgtaccc gggaatggtg tggcaggaca gagacattta ctaccaaggg     1440

cccatttggg ccaaaattcc acacacggat ggacactttc acccgtctcc tctcattggc     1500

ggatttggac tgaaaagccc gcctccacaa atattcatca aaaacactcc tgtacccgcc     1560

aatcccgcaa cgaccttctc tccggccaga atcaacagct tcatcaccca gtacagcacc     1620

ggacaggtgg ctgtcaaaat agaatgggaa atccagaagg agcggtccaa gagatggaac     1680

ccagaggtcc agttcacgtc caactacgga gcacaggact cgcttctctg ggctcccgac     1740

aacgccggag cctacaaaga gcccagggcc attggatccc gatacctcac caaccacctc     1800

tag                                                                   1803


<210> 5294
<211> 1617
<212> DNA
<213> Bovine adeno-associated virus

<400> 5294
atgcgtgcag cagctggcgg aaatggtggc gatgcgggac aaggtgccga gggagtgggt       60

aatgcctccg gtgattggca ttgcgattcc acttggtcag agagccacgt caccaccacc      120

tcaacccgca cctgggtcct gccgacctac aacaaccacc tgtacctgcg gctcggctcg      180

agcaacgcca gcgacacctt caacggattc tccaccccct ggggatactt tgactttaac      240

cgcttccact gccacttctc gccaagagac tggcaaaggc tcatcaacaa ccactgggga      300

ctgcgcccca aaagcatgca agtccgcatc ttcaacatcc aagttaagga ggtcacgacg      360

tctaacgggg agacgaccgt atccaacaac ctcaccagca cggtccagat ctttgcggac      420

agcacgtacg agctcccgta cgtgatggat gcaggtcagg agggcagctt gcctcctttc      480

cccaacgacg tgttcatggt gcctcagtac gggtactgcg gactggtaac cggaggcagc      540

tctcaaaacc agacagacag aaatgccttc tactgtctgg agtactttcc cagccagatg      600

ctgagaaccg gaaacaactt tgagatggtg tacaagtttg aaaacgtgcc cttccactcc      660

atgtacgctc acagccagag cctggatagg ctgatgaacc cgctgctgga ccagtacctg      720

tgggagctcc agtctaccac ctctggagga actctcaacc agggcaattc agccaccaac      780

tttgccaagc tgaccaaaac aaacttttct ggctaccgca aaaactggct cccggggccc      840

atgatgaagc agcagagatt ctccaagact gccagtcaaa actacaagat tccccaggga      900

agaaacaaca gtctgctcca ttatgagacc agaactaccc tcgacggaag atggagcaat      960

tttgccccgg gaacggccat ggcaaccgca gccaacgacg ccaccgactt ctctcaggcc     1020

cagctcatct ttgcggggcc caacatcacc ggcaacacca ccacagatgc caataacctg     1080

atgttcactt cagaagatga acttagggcc accaaccccc gggacactga cctgtttggc     1140

cacctggcaa ccaaccagca aaacgccacc accgttccta ccgtagacga cgtggacgga     1200

gtcggcgtgt acccgggaat ggtgtggcag gacagagaca tttactacca agggcccatt     1260

tgggccaaaa ttccacacac ggatggacac tttcacccgt ctcctctcat tggcggattt     1320

ggactgaaaa gcccgcctcc acaaatattc atcaaaaaca ctcctgtacc cgccaatccc     1380

gcaacgacct tctctccggc cagaatcaac agcttcatca cccagtacag caccggacag     1440

gtggctgtca aaatagaatg ggaaatccag aaggagcggt ccaagagatg gaacccagag     1500

gtccagttca cgtccaacta cggagcacag gactcgcttc tctgggctcc cgacaacgcc     1560

ggagcctaca aagagcccag ggccattgga tcccgatacc tcaccaacca cctctag        1617


<210> 5295
<211> 1173
<212> DNA
<213> Bovine adeno-associated virus

<400> 5295
atggcgctgg taagctggct ggtggaacat ggcatcactt ccgagaagca gtggattcag       60

gagaatcagg agagctacct gtccttcaac tccacgggaa actctcggag ccagattaaa      120

gccgcgcttg acaacgcgtc aaaaattatg agtctgacca aatctgcctc agactatctc      180

gtgggacaga ctgttccaga ggacatttct gaaaacagaa tctggcagat ttttgatctc      240

aacggctacg acccggcata cgcgggctct gttctctacg gctggtgcac tcgcgccttt      300

ggaaagagga acaccgtctg gctgtatgga cccgcgacca ccggaaagac caacatcgcg      360

gaagccatct ctcacaccgt gcccttttat ggctgtgtga actggactaa tgagaacttt      420

ccctttaatg actgtgtgga aaaaatgttg atctggtggg aggagggaaa gatgaccagc      480

aaggtggtgg aacccgccaa ggccatcttg ggggggtcta gagtacgagt ggatcaaaaa      540

tgtaaatcct ctgtacaagt agactctacc ccggtgatta tcacctccaa tactaacatg      600

tgtgtggtgg tggatgggaa ctccacgacc tttgaacacc agcagccgct ggaagaccgc      660

atgttcagat ttgaactcat gcggcggctc ccgccagatt ttggcaagat taccaagcag      720

gaagtcaaag acttttttgc ttgggcaaag gtcaaccagg tgccggtgac tcacgagttt      780

atggttccca agaaagtggc gggaactgag agggcggaga cttctagaaa acgcccactg      840

gatgacgtca ccaataccaa ctataaaagt ccggagaagc gggcccggct ctcagttgtt      900

cctgagacgc ctcgcagttc agacgtgcct gtagagcccg ctcctctgcg acctctcaac      960

tggtcttcca ggtatgaatg cagatgtgac tatcatgcta aatttgactc tgtaacgggg     1020

gaatgtgacg agtgtgaata tttgaatcgg ggcaaaaatg gctgtatctt tcataatgct     1080

acacattgtc aaatttgtca cgctgttcct ccatgggaaa aggaaaatgt gtcagatttt     1140

aatgattttg atgactgtaa taaagagcag taa                                  1173


<210> 5296
<211> 1833
<212> DNA
<213> Bovine adeno-associated virus

<400> 5296
atggctacct tctatgaagt cattgttcgc gttccatttg atgtggaaga gcacctgcct       60

ggaatttctg acaactttgt agactgggta actggtcaaa tttgggagct gcctcccgag      120

tcagatttga atttgactct gattgagcag cctcagctga cggtggctga cagaattcgc      180

cgcgtgttcc tgtacgagtg gaacaaattt tccaagcagg agagcaaatt ctttgtgcag      240

tttgaaaagg gatctgaata ttttcatctg cacacgctcg tggagacctc cggcatctct      300

tctatggtcc ttggccgcta cgtgagtcag attcgcgccc agctggtgaa ggtggtgttc      360

cagaacattg agccgcggat taacgactgg gtcgccatca ccaaggtaaa gaagggcgga      420

gccaataagg tggtggattc tgggtatatt cccgcctacc tgctgccgaa ggtccaacca      480

gagcttcagt gggcgtggac taacctcgaa gagtataaat tggccgccct caatctggag      540

gagcgcaaac ggctcgtcgc tcagtttcag cttgagtcct cgcagcgctc gcaagaggca      600

tcttcccaga gggacgtttc ggctgacccg gtcatcaaga gcaagacttc ccagaaatac      660

atggcgctgg taagctggct ggtggaacat ggcatcactt ccgagaagca gtggattcag      720

gagaatcagg agagctacct gtccttcaac tccacgggaa actctcggag ccagattaaa      780

gccgcgcttg acaacgcgtc aaaaattatg agtctgacca aatctgcctc agactatctc      840

gtgggacaga ctgttccaga ggacatttct gaaaacagaa tctggcagat ttttgatctc      900

aacggctacg acccggcata cgcgggctct gttctctacg gctggtgcac tcgcgccttt      960

ggaaagagga acaccgtctg gctgtatgga cccgcgacca ccggaaagac caacatcgcg     1020

gaagccatct ctcacaccgt gcccttttat ggctgtgtga actggactaa tgagaacttt     1080

ccctttaatg actgtgtgga aaaaatgttg atctggtggg aggagggaaa gatgaccagc     1140

aaggtggtgg aacccgccaa ggccatcttg ggggggtcta gagtacgagt ggatcaaaaa     1200

tgtaaatcct ctgtacaagt agactctacc ccggtgatta tcacctccaa tactaacatg     1260

tgtgtggtgg tggatgggaa ctccacgacc tttgaacacc agcagccgct ggaagaccgc     1320

atgttcagat ttgaactcat gcggcggctc ccgccagatt ttggcaagat taccaagcag     1380

gaagtcaaag acttttttgc ttgggcaaag gtcaaccagg tgccggtgac tcacgagttt     1440

atggttccca agaaagtggc gggaactgag agggcggaga cttctagaaa acgcccactg     1500

gatgacgtca ccaataccaa ctataaaagt ccggagaagc gggcccggct ctcagttgtt     1560

cctgagacgc ctcgcagttc agacgtgcct gtagagcccg ctcctctgcg acctctcaac     1620

tggtcttcca ggtatgaatg cagatgtgac tatcatgcta aatttgactc tgtaacgggg     1680

gaatgtgacg agtgtgaata tttgaatcgg ggcaaaaatg gctgtatctt tcataatgct     1740

acacattgtc aaatttgtca cgctgttcct ccatgggaaa aggaaaatgt gtcagatttt     1800

aatgattttg atgactgtaa taaagagcag taa                                  1833


<210> 5297
<211> 2211
<212> DNA
<213> Bovine adeno-associated virus

<400> 5297
atgtcttttg ttgaccaccc tccagattgg ttggaatcga tcggcgacgg ctttcgtgaa       60

tttctcggcc ttgaggcggg tcccccgaaa cccaaggcca atcaacagaa gcaagataac      120

gctcgaggtc ttgtgcttcc tgggtacaag tatcttggtc ctgggaacgg ccttgataag      180

ggcgatcctg tcaattttgc tgacgaggtt gcccgagagc acgacctctc ctaccagaaa      240

cagcttgagg cgggcgataa cccttacctc aagtacaacc acgcggacgc agagtttcag      300

gagaaactcg cttctgacac ttcttttggg ggaaaccttg ggaaggctgt tttccaggct      360

aaaaagagga ttctcgaacc tcttggcctg gttgagacgc cggataaaac ggcgcctgcg      420

gcaaaaaaga ggcctctaga gcagagtcct caagagccag actcctcgag cggagttggc      480

aagaaaggca aacagcctgc cagaaagaga ctcaactttg acgacgaacc tggagccgga      540

gacgggcctc ccccagaagg accatcttcc ggagctatgt ctactgagac tgaaatgcgt      600

gcagcagctg gcggaaatgg tggcgatgcg ggacaaggtg ccgagggagt gggtaatgcc      660

tccggtgatt ggcattgcga ttccacttgg tcagagagcc acgtcaccac cacctcaacc      720

cgcacctggg tcctgccgac ctacaacaac cacctgtacc tgcggctcgg ctcgagcaac      780

gccagcgaca ccttcaacgg attctccacc ccctggggat actttgactt taaccgcttc      840

cactgccact tctcgccaag agactggcaa aggctcatca acaaccactg gggactgcgc      900

cccaaaagca tgcaagtccg catcttcaac atccaagtta aggaggtcac gacgtctaac      960

ggggagacga ccgtatccaa caacctcacc agcacggtcc agatctttgc ggacagcacg     1020

tacgagctcc cgtacgtgat ggatgcaggt caggagggca gcttgcctcc tttccccaac     1080

gacgtgttca tggtgcctca gtacgggtac tgcggactgg taaccggagg cagctctcaa     1140

aaccagacag acagaaatgc cttctactgt ctggagtact ttcccagcca gatgctgaga     1200

accggaaaca actttgagat ggtgtacaag tttgaaaacg tgcccttcca ctccatgtac     1260

gctcacagcc agagcctgga taggctgatg aacccgctgc tggaccagta cctgtgggag     1320

ctccagtcta ccacctctgg aggaactctc aaccagggca attcagccac caactttgcc     1380

aagctgacca aaacaaactt ttctggctac cgcaaaaact ggctcccggg gcccatgatg     1440

aagcagcaga gattctccaa gactgccagt caaaactaca agattcccca gggaagaaac     1500

aacagtctgc tccattatga gaccagaact accctcgacg gaagatggag caattttgcc     1560

ccgggaacgg ccatggcaac cgcagccaac gacgccaccg acttctctca ggcccagctc     1620

atctttgcgg ggcccaacat caccggcaac accaccacag atgccaataa cctgatgttc     1680

acttcagaag atgaacttag ggccaccaac ccccgggaca ctgacctgtt tggccacctg     1740

gcaaccaacc agcaaaacgc caccaccgtt cctaccgtag acgacgtgga cggagtcggc     1800

gtgtacccgg gaatggtgtg gcaggacaga gacatttact accaagggcc catttgggcc     1860

aaaattccac acacggatgg acactttcac ccgtctcctc tcattggcgg atttggactg     1920

aaaagcccgc ctccacaaat attcatcaaa aacactcctg tacccgccaa tcccgcaacg     1980

accttctctc cggccagaat caacagcttc atcacccagt acagcaccgg acaggtggct     2040

gtcaaaatag aatgggaaat ccagaaggag cggtccaaga gatggaaccc agaggtccag     2100

ttcacgtcca actacggagc acaggactcg cttctctggg ctcccgacaa cgccggagcc     2160

tacaaagagc ccagggccat tggatcccga tacctcacca accacctcta g              2211


<210> 5298
<211> 4694
<212> DNA
<213> Bovine adeno-associated virus

<400> 5298
gtggcactcc cccccctgtc gcgttcgctc gttcgctggc tcgattgggg gggtggcagc       60

tcaaagagct gccagacgac ggccctctgg gccgtcgccc ccccaatcga gccagcgaac      120

gagcgaacgc gacagggggg ggagtgccac actctctagc aagggggttt tgtaggtggt      180

gatgtcattg ttgatgtcat tatagttgtc acgcgatagt taatgattaa cagtcatgtg      240

atgtgtgtta tccaatagga tgaaagcgcg cgaatgagat ctcgcgagac ttccggggta      300

taaaaggggt gagtgaacga gcccgccgcc attctctgct ctggactgct agaggaccct      360

cgctgccatg gctaccttct atgaagtcat tgttcgcgtt ccatttgatg tggaagagca      420

cctgcctgga atttctgaca actttgtaga ctgggtaact ggtcaaattt gggagctgcc      480

tcccgagtca gatttgaatt tgactctgat tgagcagcct cagctgacgg tggctgacag      540

aattcgccgc gtgttcctgt acgagtggaa caaattttcc aagcaggaga gcaaattctt      600

tgtgcagttt gaaaagggat ctgaatattt tcatctgcac acgctcgtgg agacctccgg      660

catctcttct atggtccttg gccgctacgt gagtcagatt cgcgcccagc tggtgaaggt      720

ggtgttccag aacattgagc cgcggattaa cgactgggtc gccatcacca aggtaaagaa      780

gggcggagcc aataaggtgg tggattctgg gtatattccc gcctacctgc tgccgaaggt      840

ccaaccagag cttcagtggg cgtggactaa cctcgaagag tataaattgg ccgccctcaa      900

tctggaggag cgcaaacggc tcgtcgctca gtttcagctt gagtcctcgc agcgctcgca      960

agaggcatct tcccagaggg acgtttcggc tgacccggtc atcaagagca agacttccca     1020

gaaatacatg gcgctggtaa gctggctggt ggaacatggc atcacttccg agaagcagtg     1080

gattcaggag aatcaggaga gctacctgtc cttcaactcc acgggaaact ctcggagcca     1140

gattaaagcc gcgcttgaca acgcgtcaaa aattatgagt ctgaccaaat ctgcctcaga     1200

ctatctcgtg ggacagactg ttccagagga catttctgaa aacagaatct ggcagatttt     1260

tgatctcaac ggctacgacc cggcatacgc gggctctgtt ctctacggct ggtgcactcg     1320

cgcctttgga aagaggaaca ccgtctggct gtatggaccc gcgaccaccg gaaagaccaa     1380

catcgcggaa gccatctctc acaccgtgcc cttttatggc tgtgtgaact ggactaatga     1440

gaactttccc tttaatgact gtgtggaaaa aatgttgatc tggtgggagg agggaaagat     1500

gaccagcaag gtggtggaac ccgccaaggc catcttgggg gggtctagag tacgagtgga     1560

tcaaaaatgt aaatcctctg tacaagtaga ctctaccccg gtgattatca cctccaatac     1620

taacatgtgt gtggtggtgg atgggaactc cacgaccttt gaacaccagc agccgctgga     1680

agaccgcatg ttcagatttg aactcatgcg gcggctcccg ccagattttg gcaagattac     1740

caagcaggaa gtcaaagact tttttgcttg ggcaaaggtc aaccaggtgc cggtgactca     1800

cgagtttatg gttcccaaga aagtggcggg aactgagagg gcggagactt ctagaaaacg     1860

cccactggat gacgtcacca ataccaacta taaaagtccg gagaagcggg cccggctctc     1920

agttgttcct gagacgcctc gcagttcaga cgtgcctgta gagcccgctc ctctgcgacc     1980

tctcaactgg tcttccaggt atgaatgcag atgtgactat catgctaaat ttgactctgt     2040

aacgggggaa tgtgacgagt gtgaatattt gaatcggggc aaaaatggct gtatctttca     2100

taatgctaca cattgtcaaa tttgtcacgc tgttcctcca tgggaaaagg aaaatgtgtc     2160

agattttaat gattttgatg actgtaataa agagcagtaa ataaagtgag tagtcatgtc     2220

ttttgttgac caccctccag attggttgga atcgatcggc gacggctttc gtgaatttct     2280

cggccttgag gcgggtcccc cgaaacccaa ggccaatcaa cagaagcaag ataacgctcg     2340

aggtcttgtg cttcctgggt acaagtatct tggtcctggg aacggccttg ataagggcga     2400

tcctgtcaat tttgctgacg aggttgcccg agagcacgac ctctcctacc agaaacagct     2460

tgaggcgggc gataaccctt acctcaagta caaccacgcg gacgcagagt ttcaggagaa     2520

actcgcttct gacacttctt ttgggggaaa ccttgggaag gctgttttcc aggctaaaaa     2580

gaggattctc gaacctcttg gcctggttga gacgccggat aaaacggcgc ctgcggcaaa     2640

aaagaggcct ctagagcaga gtcctcaaga gccagactcc tcgagcggag ttggcaagaa     2700

aggcaaacag cctgccagaa agagactcaa ctttgacgac gaacctggag ccggagacgg     2760

gcctccccca gaaggaccat cttccggagc tatgtctact gagactgaaa tgcgtgcagc     2820

agctggcgga aatggtggcg atgcgggaca aggtgccgag ggagtgggta atgcctccgg     2880

tgattggcat tgcgattcca cttggtcaga gagccacgtc accaccacct caacccgcac     2940

ctgggtcctg ccgacctaca acaaccacct gtacctgcgg ctcggctcga gcaacgccag     3000

cgacaccttc aacggattct ccaccccctg gggatacttt gactttaacc gcttccactg     3060

ccacttctcg ccaagagact ggcaaaggct catcaacaac cactggggac tgcgccccaa     3120

aagcatgcaa gtccgcatct tcaacatcca agttaaggag gtcacgacgt ctaacgggga     3180

gacgaccgta tccaacaacc tcaccagcac ggtccagatc tttgcggaca gcacgtacga     3240

gctcccgtac gtgatggatg caggtcagga gggcagcttg cctcctttcc ccaacgacgt     3300

gttcatggtg cctcagtacg ggtactgcgg actggtaacc ggaggcagct ctcaaaacca     3360

gacagacaga aatgccttct actgtctgga gtactttccc agccagatgc tgagaaccgg     3420

aaacaacttt gagatggtgt acaagtttga aaacgtgccc ttccactcca tgtacgctca     3480

cagccagagc ctggataggc tgatgaaccc gctgctggac cagtacctgt gggagctcca     3540

gtctaccacc tctggaggaa ctctcaacca gggcaattca gccaccaact ttgccaagct     3600

gaccaaaaca aacttttctg gctaccgcaa aaactggctc ccggggccca tgatgaagca     3660

gcagagattc tccaagactg ccagtcaaaa ctacaagatt ccccagggaa gaaacaacag     3720

tctgctccat tatgagacca gaactaccct cgacggaaga tggagcaatt ttgccccggg     3780

aacggccatg gcaaccgcag ccaacgacgc caccgacttc tctcaggccc agctcatctt     3840

tgcggggccc aacatcaccg gcaacaccac cacagatgcc aataacctga tgttcacttc     3900

agaagatgaa cttagggcca ccaacccccg ggacactgac ctgtttggcc acctggcaac     3960

caaccagcaa aacgccacca ccgttcctac cgtagacgac gtggacggag tcggcgtgta     4020

cccgggaatg gtgtggcagg acagagacat ttactaccaa gggcccattt gggccaaaat     4080

tccacacacg gatggacact ttcacccgtc tcctctcatt ggcggatttg gactgaaaag     4140

cccgcctcca caaatattca tcaaaaacac tcctgtaccc gccaatcccg caacgacctt     4200

ctctccggcc agaatcaaca gcttcatcac ccagtacagc accggacagg tggctgtcaa     4260

aatagaatgg gaaatccaga aggagcggtc caagagatgg aacccagagg tccagttcac     4320

gtccaactac ggagcacagg actcgcttct ctgggctccc gacaacgccg gagcctacaa     4380

agagcccagg gccattggat cccgatacct caccaaccac ctctagccca attctgttgc     4440

ataccctcaa taaaccgtgt attcgtttca gtaaaatact gcctcttgtg gtcattcggc     4500

gtacaacagc ttacaacaac aacaaaaccc ccttgctaga gagtgtggca ctcccccccc     4560

tgtcgcgttc gctcgttcgc tggctcgatt gggggggtgg cagctcaaag agctgccaga     4620

cgacggccct ctgggccgtc gcccccccaa tcgagccagc gaacgagcga acgcgacagg     4680

ggggggagtg ccac                                                       4694


<210> 5299
<211> 390
<212> PRT
<213> Bovine adeno-associated virus

<400> 5299
Met Ala Leu Val Ser Trp Leu Val Glu His Gly Ile Thr Ser Glu Lys 
1               5                   10                  15      


Gln Trp Ile Gln Glu Asn Gln Glu Ser Tyr Leu Ser Phe Asn Ser Thr 
            20                  25                  30          


Gly Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Ser Lys 
        35                  40                  45              


Ile Met Ser Leu Thr Lys Ser Ala Ser Asp Tyr Leu Val Gly Gln Thr 
    50                  55                  60                  


Val Pro Glu Asp Ile Ser Glu Asn Arg Ile Trp Gln Ile Phe Asp Leu 
65                  70                  75                  80  


Asn Gly Tyr Asp Pro Ala Tyr Ala Gly Ser Val Leu Tyr Gly Trp Cys 
                85                  90                  95      


Thr Arg Ala Phe Gly Lys Arg Asn Thr Val Trp Leu Tyr Gly Pro Ala 
            100                 105                 110         


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ser His Thr Val Pro 
        115                 120                 125             


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
    130                 135                 140                 


Cys Val Glu Lys Met Leu Ile Trp Trp Glu Glu Gly Lys Met Thr Ser 
145                 150                 155                 160 


Lys Val Val Glu Pro Ala Lys Ala Ile Leu Gly Gly Ser Arg Val Arg 
                165                 170                 175     


Val Asp Gln Lys Cys Lys Ser Ser Val Gln Val Asp Ser Thr Pro Val 
            180                 185                 190         


Ile Ile Thr Ser Asn Thr Asn Met Cys Val Val Val Asp Gly Asn Ser 
        195                 200                 205             


Thr Thr Phe Glu His Gln Gln Pro Leu Glu Asp Arg Met Phe Arg Phe 
    210                 215                 220                 


Glu Leu Met Arg Arg Leu Pro Pro Asp Phe Gly Lys Ile Thr Lys Gln 
225                 230                 235                 240 


Glu Val Lys Asp Phe Phe Ala Trp Ala Lys Val Asn Gln Val Pro Val 
                245                 250                 255     


Thr His Glu Phe Met Val Pro Lys Lys Val Ala Gly Thr Glu Arg Ala 
            260                 265                 270         


Glu Thr Ser Arg Lys Arg Pro Leu Asp Asp Val Thr Asn Thr Asn Tyr 
        275                 280                 285             


Lys Ser Pro Glu Lys Arg Ala Arg Leu Ser Val Val Pro Glu Thr Pro 
    290                 295                 300                 


Arg Ser Ser Asp Val Pro Val Glu Pro Ala Pro Leu Arg Pro Leu Asn 
305                 310                 315                 320 


Trp Ser Ser Arg Tyr Glu Cys Arg Cys Asp Tyr His Ala Lys Phe Asp 
                325                 330                 335     


Ser Val Thr Gly Glu Cys Asp Glu Cys Glu Tyr Leu Asn Arg Gly Lys 
            340                 345                 350         


Asn Gly Cys Ile Phe His Asn Ala Thr His Cys Gln Ile Cys His Ala 
        355                 360                 365             


Val Pro Pro Trp Glu Lys Glu Asn Val Ser Asp Phe Asn Asp Phe Asp 
    370                 375                 380                 


Asp Cys Asn Lys Glu Gln 
385                 390 


<210> 5300
<211> 610
<212> PRT
<213> Bovine adeno-associated virus

<400> 5300
Met Ala Thr Phe Tyr Glu Val Ile Val Arg Val Pro Phe Asp Val Glu 
1               5                   10                  15      


Glu His Leu Pro Gly Ile Ser Asp Asn Phe Val Asp Trp Val Thr Gly 
            20                  25                  30          


Gln Ile Trp Glu Leu Pro Pro Glu Ser Asp Leu Asn Leu Thr Leu Ile 
        35                  40                  45              


Glu Gln Pro Gln Leu Thr Val Ala Asp Arg Ile Arg Arg Val Phe Leu 
    50                  55                  60                  


Tyr Glu Trp Asn Lys Phe Ser Lys Gln Glu Ser Lys Phe Phe Val Gln 
65                  70                  75                  80  


Phe Glu Lys Gly Ser Glu Tyr Phe His Leu His Thr Leu Val Glu Thr 
                85                  90                  95      


Ser Gly Ile Ser Ser Met Val Leu Gly Arg Tyr Val Ser Gln Ile Arg 
            100                 105                 110         


Ala Gln Leu Val Lys Val Val Phe Gln Asn Ile Glu Pro Arg Ile Asn 
        115                 120                 125             


Asp Trp Val Ala Ile Thr Lys Val Lys Lys Gly Gly Ala Asn Lys Val 
    130                 135                 140                 


Val Asp Ser Gly Tyr Ile Pro Ala Tyr Leu Leu Pro Lys Val Gln Pro 
145                 150                 155                 160 


Glu Leu Gln Trp Ala Trp Thr Asn Leu Glu Glu Tyr Lys Leu Ala Ala 
                165                 170                 175     


Leu Asn Leu Glu Glu Arg Lys Arg Leu Val Ala Gln Phe Gln Leu Glu 
            180                 185                 190         


Ser Ser Gln Arg Ser Gln Glu Ala Ser Ser Gln Arg Asp Val Ser Ala 
        195                 200                 205             


Asp Pro Val Ile Lys Ser Lys Thr Ser Gln Lys Tyr Met Ala Leu Val 
    210                 215                 220                 


Ser Trp Leu Val Glu His Gly Ile Thr Ser Glu Lys Gln Trp Ile Gln 
225                 230                 235                 240 


Glu Asn Gln Glu Ser Tyr Leu Ser Phe Asn Ser Thr Gly Asn Ser Arg 
                245                 250                 255     


Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Ser Lys Ile Met Ser Leu 
            260                 265                 270         


Thr Lys Ser Ala Ser Asp Tyr Leu Val Gly Gln Thr Val Pro Glu Asp 
        275                 280                 285             


Ile Ser Glu Asn Arg Ile Trp Gln Ile Phe Asp Leu Asn Gly Tyr Asp 
    290                 295                 300                 


Pro Ala Tyr Ala Gly Ser Val Leu Tyr Gly Trp Cys Thr Arg Ala Phe 
305                 310                 315                 320 


Gly Lys Arg Asn Thr Val Trp Leu Tyr Gly Pro Ala Thr Thr Gly Lys 
                325                 330                 335     


Thr Asn Ile Ala Glu Ala Ile Ser His Thr Val Pro Phe Tyr Gly Cys 
            340                 345                 350         


Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp Cys Val Glu Lys 
        355                 360                 365             


Met Leu Ile Trp Trp Glu Glu Gly Lys Met Thr Ser Lys Val Val Glu 
    370                 375                 380                 


Pro Ala Lys Ala Ile Leu Gly Gly Ser Arg Val Arg Val Asp Gln Lys 
385                 390                 395                 400 


Cys Lys Ser Ser Val Gln Val Asp Ser Thr Pro Val Ile Ile Thr Ser 
                405                 410                 415     


Asn Thr Asn Met Cys Val Val Val Asp Gly Asn Ser Thr Thr Phe Glu 
            420                 425                 430         


His Gln Gln Pro Leu Glu Asp Arg Met Phe Arg Phe Glu Leu Met Arg 
        435                 440                 445             


Arg Leu Pro Pro Asp Phe Gly Lys Ile Thr Lys Gln Glu Val Lys Asp 
    450                 455                 460                 


Phe Phe Ala Trp Ala Lys Val Asn Gln Val Pro Val Thr His Glu Phe 
465                 470                 475                 480 


Met Val Pro Lys Lys Val Ala Gly Thr Glu Arg Ala Glu Thr Ser Arg 
                485                 490                 495     


Lys Arg Pro Leu Asp Asp Val Thr Asn Thr Asn Tyr Lys Ser Pro Glu 
            500                 505                 510         


Lys Arg Ala Arg Leu Ser Val Val Pro Glu Thr Pro Arg Ser Ser Asp 
        515                 520                 525             


Val Pro Val Glu Pro Ala Pro Leu Arg Pro Leu Asn Trp Ser Ser Arg 
    530                 535                 540                 


Tyr Glu Cys Arg Cys Asp Tyr His Ala Lys Phe Asp Ser Val Thr Gly 
545                 550                 555                 560 


Glu Cys Asp Glu Cys Glu Tyr Leu Asn Arg Gly Lys Asn Gly Cys Ile 
                565                 570                 575     


Phe His Asn Ala Thr His Cys Gln Ile Cys His Ala Val Pro Pro Trp 
            580                 585                 590         


Glu Lys Glu Asn Val Ser Asp Phe Asn Asp Phe Asp Asp Cys Asn Lys 
        595                 600                 605             


Glu Gln 
    610 


<210> 5301
<211> 736
<212> PRT
<213> Bovine adeno-associated virus

<400> 5301
Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Ser Ile Gly Asp 
1               5                   10                  15      


Gly Phe Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Ala Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Asp Pro Val 
    50                  55                  60                  


Asn Phe Ala Asp Glu Val Ala Arg Glu His Asp Leu Ser Tyr Gln Lys 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Ser Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro Leu 
        115                 120                 125             


Gly Leu Val Glu Thr Pro Asp Lys Thr Ala Pro Ala Ala Lys Lys Arg 
    130                 135                 140                 


Pro Leu Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Lys Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Asp Asp Glu 
                165                 170                 175     


Pro Gly Ala Gly Asp Gly Pro Pro Pro Glu Gly Pro Ser Ser Gly Ala 
            180                 185                 190         


Met Ser Thr Glu Thr Glu Met Arg Ala Ala Ala Gly Gly Asn Gly Gly 
        195                 200                 205             


Asp Ala Gly Gln Gly Ala Glu Gly Val Gly Asn Ala Ser Gly Asp Trp 
    210                 215                 220                 


His Cys Asp Ser Thr Trp Ser Glu Ser His Val Thr Thr Thr Ser Thr 
225                 230                 235                 240 


Arg Thr Trp Val Leu Pro Thr Tyr Asn Asn His Leu Tyr Leu Arg Leu 
                245                 250                 255     


Gly Ser Ser Asn Ala Ser Asp Thr Phe Asn Gly Phe Ser Thr Pro Trp 
            260                 265                 270         


Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp 
        275                 280                 285             


Trp Gln Arg Leu Ile Asn Asn His Trp Gly Leu Arg Pro Lys Ser Met 
    290                 295                 300                 


Gln Val Arg Ile Phe Asn Ile Gln Val Lys Glu Val Thr Thr Ser Asn 
305                 310                 315                 320 


Gly Glu Thr Thr Val Ser Asn Asn Leu Thr Ser Thr Val Gln Ile Phe 
                325                 330                 335     


Ala Asp Ser Thr Tyr Glu Leu Pro Tyr Val Met Asp Ala Gly Gln Glu 
            340                 345                 350         


Gly Ser Leu Pro Pro Phe Pro Asn Asp Val Phe Met Val Pro Gln Tyr 
        355                 360                 365             


Gly Tyr Cys Gly Leu Val Thr Gly Gly Ser Ser Gln Asn Gln Thr Asp 
    370                 375                 380                 


Arg Asn Ala Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg 
385                 390                 395                 400 


Thr Gly Asn Asn Phe Glu Met Val Tyr Lys Phe Glu Asn Val Pro Phe 
                405                 410                 415     


His Ser Met Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro 
            420                 425                 430         


Leu Leu Asp Gln Tyr Leu Trp Glu Leu Gln Ser Thr Thr Ser Gly Gly 
        435                 440                 445             


Thr Leu Asn Gln Gly Asn Ser Ala Thr Asn Phe Ala Lys Leu Thr Lys 
    450                 455                 460                 


Thr Asn Phe Ser Gly Tyr Arg Lys Asn Trp Leu Pro Gly Pro Met Met 
465                 470                 475                 480 


Lys Gln Gln Arg Phe Ser Lys Thr Ala Ser Gln Asn Tyr Lys Ile Pro 
                485                 490                 495     


Gln Gly Arg Asn Asn Ser Leu Leu His Tyr Glu Thr Arg Thr Thr Leu 
            500                 505                 510         


Asp Gly Arg Trp Ser Asn Phe Ala Pro Gly Thr Ala Met Ala Thr Ala 
        515                 520                 525             


Ala Asn Asp Ala Thr Asp Phe Ser Gln Ala Gln Leu Ile Phe Ala Gly 
    530                 535                 540                 


Pro Asn Ile Thr Gly Asn Thr Thr Thr Asp Ala Asn Asn Leu Met Phe 
545                 550                 555                 560 


Thr Ser Glu Asp Glu Leu Arg Ala Thr Asn Pro Arg Asp Thr Asp Leu 
                565                 570                 575     


Phe Gly His Leu Ala Thr Asn Gln Gln Asn Ala Thr Thr Val Pro Thr 
            580                 585                 590         


Val Asp Asp Val Asp Gly Val Gly Val Tyr Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Ile Tyr Tyr Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Ile Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Ser Pro Pro Pro Gln Ile Phe Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Ala Thr Thr Phe Ser Pro Ala Arg Ile Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ala Val Lys Ile Glu Trp Glu Ile Gln 
        675                 680                 685             


Lys Glu Arg Ser Lys Arg Trp Asn Pro Glu Val Gln Phe Thr Ser Asn 
    690                 695                 700                 


Tyr Gly Ala Gln Asp Ser Leu Leu Trp Ala Pro Asp Asn Ala Gly Ala 
705                 710                 715                 720 


Tyr Lys Glu Pro Arg Ala Ile Gly Ser Arg Tyr Leu Thr Asn His Leu 
                725                 730                 735     


<210> 5302
<211> 600
<212> PRT
<213> Bovine adeno-associated virus

<400> 5302
Thr Ala Pro Ala Ala Lys Lys Arg Pro Leu Glu Gln Ser Pro Gln Glu 
1               5                   10                  15      


Pro Asp Ser Ser Ser Gly Val Gly Lys Lys Gly Lys Gln Pro Ala Arg 
            20                  25                  30          


Lys Arg Leu Asn Phe Asp Asp Glu Pro Gly Ala Gly Asp Gly Pro Pro 
        35                  40                  45              


Pro Glu Gly Pro Ser Ser Gly Ala Met Ser Thr Glu Thr Glu Met Arg 
    50                  55                  60                  


Ala Ala Ala Gly Gly Asn Gly Gly Asp Ala Gly Gln Gly Ala Glu Gly 
65                  70                  75                  80  


Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp Ser Glu 
                85                  90                  95      


Ser His Val Thr Thr Thr Ser Thr Arg Thr Trp Val Leu Pro Thr Tyr 
            100                 105                 110         


Asn Asn His Leu Tyr Leu Arg Leu Gly Ser Ser Asn Ala Ser Asp Thr 
        115                 120                 125             


Phe Asn Gly Phe Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
    130                 135                 140                 


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn His 
145                 150                 155                 160 


Trp Gly Leu Arg Pro Lys Ser Met Gln Val Arg Ile Phe Asn Ile Gln 
                165                 170                 175     


Val Lys Glu Val Thr Thr Ser Asn Gly Glu Thr Thr Val Ser Asn Asn 
            180                 185                 190         


Leu Thr Ser Thr Val Gln Ile Phe Ala Asp Ser Thr Tyr Glu Leu Pro 
        195                 200                 205             


Tyr Val Met Asp Ala Gly Gln Glu Gly Ser Leu Pro Pro Phe Pro Asn 
    210                 215                 220                 


Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Cys Gly Leu Val Thr Gly 
225                 230                 235                 240 


Gly Ser Ser Gln Asn Gln Thr Asp Arg Asn Ala Phe Tyr Cys Leu Glu 
                245                 250                 255     


Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Met Val 
            260                 265                 270         


Tyr Lys Phe Glu Asn Val Pro Phe His Ser Met Tyr Ala His Ser Gln 
        275                 280                 285             


Ser Leu Asp Arg Leu Met Asn Pro Leu Leu Asp Gln Tyr Leu Trp Glu 
    290                 295                 300                 


Leu Gln Ser Thr Thr Ser Gly Gly Thr Leu Asn Gln Gly Asn Ser Ala 
305                 310                 315                 320 


Thr Asn Phe Ala Lys Leu Thr Lys Thr Asn Phe Ser Gly Tyr Arg Lys 
                325                 330                 335     


Asn Trp Leu Pro Gly Pro Met Met Lys Gln Gln Arg Phe Ser Lys Thr 
            340                 345                 350         


Ala Ser Gln Asn Tyr Lys Ile Pro Gln Gly Arg Asn Asn Ser Leu Leu 
        355                 360                 365             


His Tyr Glu Thr Arg Thr Thr Leu Asp Gly Arg Trp Ser Asn Phe Ala 
    370                 375                 380                 


Pro Gly Thr Ala Met Ala Thr Ala Ala Asn Asp Ala Thr Asp Phe Ser 
385                 390                 395                 400 


Gln Ala Gln Leu Ile Phe Ala Gly Pro Asn Ile Thr Gly Asn Thr Thr 
                405                 410                 415     


Thr Asp Ala Asn Asn Leu Met Phe Thr Ser Glu Asp Glu Leu Arg Ala 
            420                 425                 430         


Thr Asn Pro Arg Asp Thr Asp Leu Phe Gly His Leu Ala Thr Asn Gln 
        435                 440                 445             


Gln Asn Ala Thr Thr Val Pro Thr Val Asp Asp Val Asp Gly Val Gly 
    450                 455                 460                 


Val Tyr Pro Gly Met Val Trp Gln Asp Arg Asp Ile Tyr Tyr Gln Gly 
465                 470                 475                 480 


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser 
                485                 490                 495     


Pro Leu Ile Gly Gly Phe Gly Leu Lys Ser Pro Pro Pro Gln Ile Phe 
            500                 505                 510         


Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Ala Thr Thr Phe Ser Pro 
        515                 520                 525             


Ala Arg Ile Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ala 
    530                 535                 540                 


Val Lys Ile Glu Trp Glu Ile Gln Lys Glu Arg Ser Lys Arg Trp Asn 
545                 550                 555                 560 


Pro Glu Val Gln Phe Thr Ser Asn Tyr Gly Ala Gln Asp Ser Leu Leu 
                565                 570                 575     


Trp Ala Pro Asp Asn Ala Gly Ala Tyr Lys Glu Pro Arg Ala Ile Gly 
            580                 585                 590         


Ser Arg Tyr Leu Thr Asn His Leu 
        595                 600 


<210> 5303
<211> 180809
<212> DNA
<213> Homo sapiens

<400> 5303
gggaggcggg gctgctacct ccacgggcgc gccctggcag gaggggcgca gtctgcttgc       60

aggcggtcgc cagcgctcca gcggcggctg tcggctttcc aattccgcca gctcggctga      120

ggctgggcta gcctgggtgc cagtggctgc tagcggcagg cgtcccctga gcaacaggag      180

cccagagaaa aagaagcagc cctgagagag cgccggggaa ggagaggccc gcgccctctc      240

ctggagccag attctgcagg tgcactgggt ggggatgatc ggcgggctag gttgcaagta      300

agtgcctttt cttttgctgc ttctgtgggg aggggaggag aagccctcgg tctttcgccc      360

gtgctcgcct caaccgccac acccacctgt gtctattttc acatctcggt tctggaaccc      420

tgtattacgc cacctggaaa gaagagaggg gagaagcttg accgggtggt tccagcaatg      480

ggaggaagaa gggctggaag cgtagttatt tcgatagctg ggcagctcct gtgcggtttt      540

gactctgtgg gtttgctgcc aggttctgaa actgtggaaa ggaagggtag caatgcctgg      600

tggtttactg tcttttattt ctgtttacgc tagcagagtt gttagatgga cttcaattca      660

aggggcagct cacatttttt acgagcaaaa agcatgtgct gtatttccca tctgcaaagc      720

tgagcgtgca gaaccagctt agcagataca acctgtgggg acagaaaaga accccgcacc      780

ccttaagagc acacaaacac aaataattga caggacagct ctgcccctat ttctcagcgc      840

agattattta tttatttttt cgaataagca ctttatagtg aaattcagaa aagatgcaga      900

atccttttaa ctttttatcg aattcaactt gggaaactca tttactttta ggaaaaaatg      960

gatattttcg tgccttatat tcaagacaaa aatcagaaca agaaactaga aacattaatg     1020

ccagtttttg tgattatagt aaacatttca ctcattattt tagttttttt tttttaagtt     1080

ggagcgttca tagattatat ctactctgat gttaagagca atttacatga gaaacttagg     1140

ggggttttta agaagctagt gtcagtaaga taaaagccaa atcaaagtaa gctttcaagg     1200

aagtgatagc ttgtcagtta ctgaatagga agtcagtgtt gggaagttca gttcttttca     1260

gaaacatatt tattattctt ttctatttct tcttccctgt agacaagata aagattttct     1320

ttctctttct ttccttgtta tttaaatata ttttataatt tttgctttaa catcaatata     1380

aacctatttt atataaactg caaaccaaat ccaattatta aactgttcat tttattgcaa     1440

attcttcaga ttttttccac tatttaaaaa agtttataat tttttcttat aattatggtg     1500

agatttttta aaaattattg attagtttga aagctagtct tatctgatcc ctgtgtcgca     1560

aattttcatg attgttagac tagcttatca acaacaaaac tctagacaga atatggtatt     1620

tgatgtaaag aagaatgtgc cctctattta ggcaactgat agtttggctt aagacaagtt     1680

ttttaaaatt ttgtagaggt ttaaaaggag gtttccttaa gtaagccact gtgcagttgt     1740

gggactcagt gatgtgtttt tacagtgact ggatatatga tatgccttga ttcctatggt     1800

gcagggctag gctcacagag tacctgatgc ttctacagaa gaaagatgag tcaggtctgg     1860

ctctctgcca aaagcatctt gggcctcctt tcccctaggg cctgcatata atcatgggag     1920

cccttctgtg gtaatgcttc tatgttttta ctacctgttg ctgtgctgag tttcagaagc     1980

aaaatagata aacaaataaa taaattcaga agagcaatca gtagggttct atttatttaa     2040

tataatcaac ccactttctc tgtggcaagg aaaaaagtag aatttttcat tttacatgaa     2100

taataaaatc tattttttat ccaatttcta ttcctattag ttatgcaaaa gagtgtgaag     2160

tgctagaagg atttatatgg tacttttcta agacaagtca tgatcttgta aaagagctta     2220

aagtttattg atgtaaatgg aacattctag atgtcataat gataataatt tatgactttc     2280

cctaaaactc tgtctcagat tctttcctcc catcttcatt atctgaataa atgccttcac     2340

catccaagta ttgaaatcac ctttgattgc tctcttcctt attactccat ttcagccctt     2400

tccagcctgt aagtagatct atcaatctta tctcccaaac ttatttctat ttcatcatac     2460

gtctcagatg cctctcattc accctctttt ctgtatctac acggccacca aattagttca     2520

ggtcatcatc ataatttact tggaatcctg ccacagcctc catatcaatc tctccacttc     2580

tgtaattttc tcccctgcaa ttcattctct atacaaagca ataccatcct gtctccccta     2640

acaaacattg gctcacaact gcatttaaaa aaaaaaaaaa agaggaagaa gaagaggaga     2700

agaagaaata aacatggcaa cacagagacc aattagcaac aacagtaaat gcctttcctc     2760

agcatatggt ttactctctg ttctgtccct tctctccaac ctcaccagaa cctattctct     2820

tctcattaag gtgctcctgc ccaggtcgtg gctaaaacac atgaaacaat agcactcttt     2880

aaggcctttt caaatgctgt tcccaatgcc tgaactctat gcgtgcttac tccttcttaa     2940

actttaaatc tcaactcgag gtttttttgt tttggaaaga tcatttttga tcatcttgtt     3000

aaaagtaggt tgtcccgtgt tggtcttgat gttggaacct tgtttctttc atactgcttg     3060

ttacagcatg caggtatttt gtgaatttgc ataccaaata ctccaaggga acccagacta     3120

tgtcttcatt gttgacttag cttccagaat agtgcctggc atcaagtagt agggggttcg     3180

tagatattta tataaataat aaaatacaaa aatatggatt cttccagaat aaagcatatt     3240

aaccctggaa acatgaattt tgtgattcta ttttttattt gtcaagcatt tagtattttt     3300

acaatatcat ggtatgatat tgaggaggta aaattaaaat atcctgagat gtattctctc     3360

ttttatcagt gtaggtgata atgtacttaa aggtaagtaa tttgtaatgc attcttagaa     3420

aggcagtgac cacaaatgta ttaaaatata ttttaagaaa aaattggatt gcataaacta     3480

atatggttat aagtgactcc aaatctaaaa tgataacctt gttaggttta aatctgtatc     3540

atctaacaga aatttgaggg ccagtcaata gtcactgact atgaatttaa aatattcttt     3600

taaaataaac atagatgctt atgtgagctc agttgataga aatgtagtca gatgaggcgg     3660

aggccataag ttaggtttcc acacggtcta aattgatgtt tgccccaggt acaaagggca     3720

cattatccaa atatttgaag cattctctaa ggaaggttca gagaggcaat gtgggcttat     3780

ccatgaagac ccatcactgt tattagagtg gaagtaagga ctgcaaactt catgctcata     3840

aatgattgtg tcattttcat actagaattt taccacacac acactcacac tcacacacac     3900

acacacacac actttgtatg gtgatttgcc tccccccttt atttttgcag actatgctta     3960

aagatattaa acaaacaact agttttgcta ttaacatttg gttgaaaatt tagctttcaa     4020

ttaggtgaca aactgattaa tgattttttt atgtagcaaa tggccagcca cagatttttg     4080

gtaaataatt tggttaccac attacatctt gaaggactaa attatttcac taattgtgag     4140

cagggatttt taaaaatttg ctctgaagag gacatattgt ggatgttgta ttggagggca     4200

tctgtgtact aattgaagat ggtccttcat attacacatc acaaattagc taatttattc     4260

tttacagaag tattatgaca tcttccttta gaactgtgta gagttagatt accacttgag     4320

aggcaaggtc atattaaaat agatattata aaattgtata aaaatatttt atatgaggat     4380

ttatgagagc atccagagaa tgtgggtaga atacttttgt ggaatatgag ataacaattt     4440

tggtgtcctg ccattctaaa aaatgaaatt tcttcattga aggtatcact taccctttcc     4500

tctgccttgc tggaaggaaa tggctttagg caaaagaaaa agccatcagc tcttggcagc     4560

taaaggtgga atgaagtttg gaggaatgaa acccttctgg gtggtgagga aaaatgccag     4620

gccatgataa agtggggaag gaagagggga atgccttgaa cagtgccagt aagcataatc     4680

tgccacagac aagtttgaat tgacatatgt agaactgaat tattctatat ctttttagtt     4740

ctatagagaa aaccgttctt tccacgtctc tttttaaaat aacaacttac tgtaagcaaa     4800

aaatatgttg ttgttgtttc tttaacacag gagatgaact atctttagat tttttaaagt     4860

gatataacat ggagccaaaa atgccatata ttactgttga aacctaacgt tactttaact     4920

gtaatttcct tgctattcat tttatgattt cctcttgtta tgtcaagtgt tagagagact     4980

gctattactg atcataaatt tctttaaaat gtctccttgg attttttaca aagctttctg     5040

aatcatttat caaaatacaa taaagctcta attgcaccta ggattgttca cttggaaatt     5100

tagaaagagt gtgtacattt acaattaagt tagcatcctg ccctgcaatg aatgcccttt     5160

ttcttttttt ttttccttct tctctcctac atctcatctt ccaaatgttt gatatgtacg     5220

ccagtaaggc aaattttact ccacttttag gtcaaactat tagtacaaat aattggaaaa     5280

ttgagcctct aaagaaagat aaataagatt agaagcatgc attaaaatat aagtattaaa     5340

aacattccca taagattttt aataaaaatt ttatgtgcta tatgcacacc tagactccct     5400

gtattatctg atttttaaag attctttttt ttttttattt tttatttttt tgagacggag     5460

tctcgctctg tcgcccaggc tggagtgcag tggcgcgatc ttggctcact gcaagctccg     5520

cgtcctgggt tcacaccatt ctcctgcctc agcctccgag tagctgggac tacaggcgcc     5580

taccaccgtg cccggctaat gtttttgtat ttttagtaga gacggagttt caccatgtta     5640

gccaggatgg tctcaatctc ctgacctagt gatccgcccg cctcgacctc ccaaagtgct     5700

gggattacaa gcatgagcca ccgcgctcag cccattatct aatgatgatg atgatgatta     5760

ttattattat tattattatt attattatta ttattattat tttaactggg ggtaatttca     5820

ctggatgtgg tatctgtcaa cttttactag ttgctcctac actatatgtt tttaaatcca     5880

atgtaattat tttaaaaata tgtcatcttc ttgagagtct atactttaga atttgaaaaa     5940

agaagtaaat gtagatattc aaatccatgc agatgagtaa aacagggaaa aatgagaaaa     6000

atgtttcatg ataataaaat attatgtcag gcacagctgg tcacccctgc aatcccatca     6060

ctttgggagg ccgaggctgg aggattgctt gatccaggag ttctagatca gcctgggcaa     6120

taaaaggaaa atctgtttct acaaaaaaat taaaatttat atttcatata ttgatttaag     6180

ctctactaaa tgactattct ttcaagtcta atagacagtg tatcttttag ggctcagagt     6240

aaagataatt tattgaggac attttgaata ggatgaatta aatgctttat tggtaagtga     6300

tgcctttatc tgagtgattc cttctaggta aatattatgg gaccaatctt tgtaaatgat     6360

ctttgcatgg aacaaaatat tataaagttg aagtgatgaa tttgtttccc tcttaacaaa     6420

atatgtattc ttgttacccc atttacaaac ttggctcatg gtaattcagg taggaaaaag     6480

ggaagtggcc tactcaggga tcaactggga ataaggttct tataatccca tgagatcagc     6540

tgacagactt ttaggaatga acacttgtag aacagctagg cagagaagtg cctttcaaaa     6600

tttatattac atctctacta tatttcagac tgtaaaatat ttttataaag tgttaaaagc     6660

acagataaat aaatttgagt tcaaattagt atagtgaaag gaagtttatt tttcccaaat     6720

atttccttta ctcagtatgt ggtcttagtc aaatattaat ttcttaaata ttgctttcct     6780

gtaaattagt agtatttact tctaaggact atattatatg ttatatatag agtatattat     6840

atattaggag atatatatgt atatacatcg taatttgttt tttccaaaac agccacttta     6900

gtgtcttaca catgataagt agatatgagt agatgttcaa taatggtatc taggcattta     6960

ataacttaga atattataat caaaatgcat tctttttttt ttttttgaga ccgagtttca     7020

ctcttgttgc ccaggctgga gtgcaatggt acgatcttgg ctcactgcaa cttccgcctc     7080

ccaggttcaa gcaattctcc tgcctcagcc tcccgagtag ccgggattac aggcatgagc     7140

cacctcgcct ggctaatttt gtatttttag tagagatagg atttcaccag gttgggcagg     7200

ctggtcttga actcctgagt tcaggtgatc tgcccgccta ggccccccaa agtgctggga     7260

ttataggcgt gagccaccat gcccagcctc tttttttttt tttttttaat taagtttcaa     7320

ggtacatttg caggatgtgc aggtttttta cataggtaaa ggtgtgccgg tttcactctg     7380

ttgcccaggc tggagtgcag tggtacgatg ttggctcgct gcaacctctg cctcccagat     7440

tcaagtgatt ctcctgcctc agcctcccaa gtagctggga ttacaggcat gtaccaccat     7500

gcccggctaa ttttgcagtt ttagtagaga tggggtttca ccatgttggc cagactagtc     7560

tcgaattcct gacctcaggt gatctgccca cctcggcctt ctaaagtgtt gggattacag     7620

gtgtaagcca ctgtgcaagg ccagcaatta tgctgttaca aggaaaaata catacggaaa     7680

agtttacatc ttgctaacat tactgataat attaatgtaa cagtcttatg tatggacgtc     7740

tccttaatgc taactgagca gtttgttaag ggattttcat atgctccgtt taaatcctca     7800

tgaccaccat ttgaggtgag aacactaagg ctcagaaatt acctaacctt tccaaagact     7860

cacaatggtt actaaacttg aataacatac acatttcttt tataggaaag aaatcttata     7920

tattccaaga atacgtttgc acatacccca cacagatata cctggtggtt acgctaccaa     7980

gcattctatc aaatatgttt aacccttaat ggagctaaaa taaaattaca tttgcaatca     8040

aacatactaa atcatgtaat tacagctaat agaaaacaac aaaaaaagaa agatggatga     8100

ctgtttcaat tttcttcttg gacaccaatt cctgaggggt atattgtgtt aagtcaaaat     8160

agagattttg gtggaagttt gaagacatta tgaaaagagt acctatgcat ttaaagtgtt     8220

tttgaagttg ttttataggt tgaatgactt cactttcctg gtctaggagt attattgcac     8280

tactgtgact tgactttgct atgattcgca tattttgttt taacattaaa aaactgaaat     8340

gggaaaaagg ccttccccaa ggtagaaaag atttgaaaaa agaggaatgg tgtaattaaa     8400

agggaaatat gtataaaatg tctagggtgg gccaggcgcg gtggcttacg cccgtaatcc     8460

agcactttgg aaggctgagg caggctgatc acttgaggtc aggagttgga gaccagcctg     8520

gtcaacatag tgaaacccca tctctactaa aaaaaataca aaaactatcc aggcatggtg     8580

gccagcacct gtagtcccag cttctcggga ggctgaggca ggagaattgc ctgaacctgg     8640

gagatggagg ttgcagtgag ctgagatcga gccactgcac tcctgcctgg gcaacagagc     8700

gagactcagt ctcaagaaaa aaaattaaaa aaatgtctag gatgaagttt attctgaaat     8760

ggagaagaaa cagggaatga agttacacac gttgagatcc tggagctagc agatggagaa     8820

gtatgaaaag caaagtgatc ttgtgcagga taagatgatg gtgttcattg gaagtattta     8880

tatatcttgg aaaataaaaa tttagatatt ctatattgga ggagtacaaa tatttagagc     8940

atcacaaatt gatacacaca aatgaaacct aaatcacagt acttattgtc atgaagactc     9000

aattatctaa gtcagttaaa ttgtctaaca tcagtaatgc aagaagttga cttttaaggg     9060

ttttaaaaca gttttggaaa actaatttat tttacattat gtttataata atttttgcat     9120

gcaatttttt taaatatcta ttatccactt agatactgta ctttgggata taaaaaccat     9180

gggaaatttg gcccttgagt tctatgatac gtctcaatct attttagtga tttgtggatt     9240

ggtagcttat cctctagact aagtggttaa ggttttatca gcactgcaat gagataatca     9300

tctcacacct gttaagatgg ctgttataaa aaagtgaaag gtgttgttga gaatgtgaag     9360

aaaatgaaag cattgtccac tgttggtggg aatgtataat agtgtagctg ctatggaaaa     9420

taatatggaa gttcctcaaa aaattaaaaa tagaactacc atatgatcca gcaattgaaa     9480

tcagaatctc aaagagatat atgcacttct gtgtttactg cagcattatt cacaatagca     9540

aaaatatgaa aacaacccaa atgatcatca acagataaaa gagtaaagaa aatgtggtct     9600

gtatataaaa tagaatatta tctagcctta aaaaaagaag gaaatcttac tatttgtgac     9660

agcatgcatg gacctagaag agacatgcta agtgaaataa gtaaagggac acgaaaactt     9720

ttgacagtga cagatatgct taacaggtag actggcagat aagaaaaaac aaagttaaag     9780

ctgaaatttc caactgattt atcttagcct agggattaat cattagatcc ggtctagttg     9840

gcctccaaaa tgtgtaggtc aggagttggc atccaagttg gtattggtgc cattgaggtt     9900

tgtagggagg gaagacctgg cagagatccc aagggcagtg gtaagcggct gctgagtccc     9960

tccaggccag ttccaagaac tcacaacctc actcctctca gcatttatac tcttcctgga    10020

atttaaaagc aattccttct ttccttccct ctttcttttt tccctctctt ccttcttcat    10080

aaagttttat tgtagacatc agatatagca atgaacaaca catggagatg tgacgccgat    10140

tttaagagat aatgaagaga taaatattcg ccactatcca tcattgtacc ataagatatg    10200

ctgtgaaaaa caataaaaca ggacagagaa ttgagagaag gaggtattat ttaaagtggt    10260

ctgaaaaatt ttatacaggg tatttgagta gagacatgaa gtaaatgaaa aactaaggga    10320

gctagctaaa caactgaaga atcattctag tcacaaaaaa cagcaattgc aaaagcccta    10380

aggcatattt gatgtattta aggagaagca agaaaaccag catggttgaa atacagacag    10440

caagattgaa agcagaagat gagggttttt cttgattttg tagggattac taacctgcgt    10500

cgagggctgc gtgataaacc aatgctaaaa ttaccagcat gggtacaact ttggaaaggg    10560

atgagtgtgc tcttttttaa ctggatctct ttctggacat gggtaacata aaaccagaaa    10620

aaaatgtttg agaagtttct aatttctata caaaaataat gtttttgtct ttttttgtga    10680

tttagatgta aatgtatatg tacatgcatg tatatgtatt tatgtactga tttactattt    10740

atgtatatgt aaatgtattt atatttaaat gtcctatatt ctcttcctgt ctgtaatgga    10800

ttggattctt ggaacctctt actatttggg gcagggggca gggctaataa gacaaagatt    10860

acaattgaga gtaactttaa atgtttgcat tttggaaact taatggtggg agtacagtaa    10920

tattttgtat atttcgatca attttgatgt ttattatatg attatttctc atgaaatagt    10980

ggtactgcat agatataaat gactactgcc tagcaaaaca gataccaagg agacaccgca    11040

tgttgtcagg gttgaccggt tgctaactgc tgtgattttg ttctcttact gactctttct    11100

gccttacgga tctcaaaaca cgctagtgaa tttaaaaatt tatattttgg taaaatatat    11160

ataacaaaat ttaccatttt aaccatttca aatgtacagt ttagaggtat taagcacatt    11220

catgttgtac acgatcacca ccatccatct tcagaacatt ttcatcattc caaacaaaaa    11280

ctcggtaact attaaacaat gactccacac tcctctcttc ccctatcacc cagtaaccac    11340

tattctactt tctctatgaa tgtgactatt ctaggtacct catgtaagtg gaaccctata    11400

gcatttgtct tttcatgtct ggcttatttc acttagcata atgttttcaa ggtgttcatc    11460

cgggtcgtag catatatcag aattttattc atttttaagg ctgtgtagta ttttattgtg    11520

catttataca cattttgttt atctgttcat ctgttgatag acatttgggt tgttttcact    11580

ttttggctac tgtgattagt gctgctatga acattggtgt acagataact acatgcgtcc    11640

cttctattaa ttgtttagga tgtataccct aaagtagaat tgctggatca tgtgatattt    11700

ctgtttaatt ttttgaggaa ccaccacagt gttttccaca gcagctgcac tattttatat    11760

tcctatcagc aatgcacaag ggttacaatt tctccacacc cttgtcaatg tttcttttcc    11820

tttttttttt ttaaacaata accatccgac caagtgtgaa gtgatatttt attgtggttt    11880

tgatttgcat ttcccaaatg atcggtgatg ttgagcatct tcccatgtac tgattgactt    11940

tctttggaaa aatgtctttt caaatccttt gttcattttt aatctgcttg tttatttttt    12000

gttgaggagt aggaattttt tacatattgc caatgttaat cccttatcag atatatgatt    12060

tgcaattatt ttctcccatc atatggattg ccttttcact ttctagtagt gttctttgat    12120

gcacaacagt ttcaattttg acaaaatcca attcagctct ttttttcttt tgttgaccgt    12180

gcttttggtt ccatgtccat gtgccaaatc taatgtctcg aagatttttc cctatgatat    12240

tttcttagaa atttacagtt ctaactctga cgtttaggtc tgtgattcat tggtgatttt    12300

ttaaaaattc ctatataatt cgtagactct aagagagttt ccagctttcc catacccatt    12360

gtccccagag atctggtttt tagtctgaat gtgccttact ctgaacatgt gccttccatt    12420

tcaagaactc ccatttcatt ttgttttgtt ctgttttttc ttttatacca gtattaaaac    12480

ttttgagttg ttgtataaat atactagcaa tttaggagaa ttcctgatgg gaaagaatat    12540

ccttgcctag ctagttaatg aatttaggga cccttcattt tctaatccta gatatgatta    12600

aatcaaacaa ggattcattg tgctgtagtt gtaatccaca cagaccattt tacaaggctt    12660

tgcacagaga aggtgcttaa tacttgagta aacaaattga attaatgagt aagaaagaaa    12720

agctatcttg ttttctcaac ggtcaagtag atcaatgatt tctactattt agaatcttag    12780

atttatttta ataaagcaag ttcaaaaatc tcctctctct gttaattttt agtaaagtca    12840

cttatttttc actcagtttt gttaaagtgt tttcagaaga gtttgttacc gaaaactgaa    12900

gttttaaggt tagtgtttat accacagata tttcttgttt ttagacaatc cttgtggagg    12960

ttaagtcccc taggcaatac cttttcccac tggggagtta caagcaaatg aaaaatggtg    13020

actatttatg gaaactccag gtcactaagt aaattttgca ttttcatgaa aatatgacat    13080

atggacattt aaaaaaatga acaggtcaat tcatcagtta gaataataaa aagaagtctg    13140

taaataaaag ttaagcacct ttgtcattga attgttgtga accgtttttg cctatgcact    13200

tgctttatct cagaatccaa gcctcctggt caaagttata ttcctaataa atttaaaaat    13260

aataatttaa taattttaat tccttctgga atataaattt gatcaggagt cttggattct    13320

gagataaagc aaatgtttag gcaaaacact tccttctgga atataaattt gaggaaggat    13380

aggaattatt ttcttcctat tcatttgtga tcctgtgatt gttatctaat ttggaatatt    13440

cttcatgact ccaatcctat ttatatctgt gaggttctga aaattctgcc ccaaaatggc    13500

agaaagtaag aaatactatc acacatttaa ttcaccctta aaaaaatagc catacccttt    13560

atctttgaat atatttttaa caacaacaac agaaagagaa tgcattttaa acaatatcac    13620

atgagtttca tcatattccc agattatggt gagggttcct agataccttg ccataatcac    13680

agcctttagt tccaagagag agcagagaaa taagaaacac aggaagtcat atctatgaac    13740

atgttagttt gcaaaaggtt tgttagtaaa ctcatgttat ttataccata gtactttacc    13800

atctccagat gaatttccac taaataaact gttcctttag actcctcaaa ccagattacc    13860

cccttccttt gctaatatag attctcaaac aatgtcttca tcaaaaatct tatgagtaga    13920

tgtcactagt tttgacaatg tccacaaatg ttccaaagaa tactttggca tgcatgcttc    13980

ttaactcact tattttgata ttgaattaaa gggcttttaa caattcctgc cccatcagga    14040

atatttcatc agcagctgtt actgtgcttg gattttgcct tcttgaatga atacctagtc    14100

ttttctcact ttagcattaa gttctggagc atccgctgct aatgaaaaat cctctgactc    14160

atgctagagc attttcattt ttttaaaaaa acaatgttcc ttgtatcttg ctggctattg    14220

cctaagctca ttattttaaa cttttgcata attctgctca gtcctagagg gtcatcatta    14280

ctgtcaatga ttaaactttt atgcacttgc cacatttatt attttcttac tttcgatcat    14340

tttattattt ttctttggtt cccatgatat tccaatgttt ttgttattaa atctttcaac    14400

atcctcggtg tgttcagtgt atccacattt atcaaacctg atggatttaa gaatttatat    14460

aaccttgaaa gcaaggccca catcctgtag acactgaata aactaatgaa ctttgtattg    14520

gcaggactaa aatggctgtg tgtggcatat attgccacct gttggtagaa ggcaatgtag    14580

tcttggtttt gctataagca tacattttag tctttaaaat attctgagtt gaaagctccc    14640

taagaagaaa aggttttgta tatgcaatac aaaagctttt ctattataaa gtaagcaaat    14700

atattctcgt tcctaagaac attagcttta ggtatacaaa atcaacttag aagaaagttg    14760

ctaaaatcac taataataac agttacaatg tattgtgcac tgaaagtgta acaggaaatg    14820

tgctaagtta ttaaaattca gtgtctaatt ttttccacta aaataacctt aaaggattat    14880

cattttcagc tccggtttgc tatataagaa ctgagcttta gagaagttaa ttaaattccc    14940

caaggacata agctagtaag cagtagagat gggatgtgaa cccatgcctc tctcactctg    15000

gagccatgaa tttaacaact gggttatgct gtcttactat tttactgcag atctatattt    15060

taaattaaag ccataaacat gtttggcaag ataaaacata ggtaacaaat atactccaca    15120

taagattttc gtaaggtttt gtgtttattg gccaactcat ggcttattat ttaaaaattt    15180

cagtctgtat agggaagaag gataataatc ttgctgttat ttatttagcc taggcactgt    15240

ggtaggcact ttaccaaaac catttctatt ctacatgata actttataag acagatatat    15300

ttctctcttt catttatggg gaatttgcat aatgctgcag agctaattat atggaataaa    15360

caggaaattc aaacctaagt ctgcctggtg ccaaagttat tactatgcac tttctcctaa    15420

atcatgttga tgttttgagg gaagtggata catgtataat aatattggaa atacattttc    15480

tctctaatta tttaaataag ggtatagaac ctgttctgca gccataagtc tgtgataatt    15540

ttgtgctctc aataaagtct taactaacag agagatggga tttaacgtga actaagaagt    15600

attttctgtc ttcctttata catgctgtac agataagact ttatgaattt tttattaaaa    15660

cgttcagata tgccagcaaa tgttgacact aatcttaagt tttcccaggg taatacactt    15720

cttaagatta taaactttaa tttctttttt tttttttctt tttttttttt ttttgagaca    15780

gagtttcgct cttgttgccc aggctggagt gcaatggccc gatctcagct cactacaatc    15840

cacctcccgg gttcaagcag ttctcctgcc tcagcctcct gagtagctgg gattacaggc    15900

atgcgccacc atgaccagct aattttgtat ttttagtaga gacggggttt ctccatgttg    15960

gtcaggctgg tcttgaattc ctgacctcag gtgatccgcc tgcctcggct tcccaaagtg    16020

ctgggattat aggcgtgagc caccacgccc ggcaaacttt catttcttat aaacttgagg    16080

aatactatat tttaaaaggc tatacataag actaacttct atcttaataa taaaataata    16140

aatataatat aaatgattat tacagggtat tatgaaatac ccaaatcaca atattttaat    16200

aatcatagaa tttagaaata gtccctatca gttgtctgaa tataaaatta tcgcatatac    16260

agcttaattt gttttgcata ccagttgttc aactactata aaatgccata aaattgaatg    16320

attttaggac atgaaatatt gaactactct tgttgaagtt attaaactga tttgccatct    16380

accaaattaa gcatttctaa gaaataataa ttattttaag aatttattta catgattaac    16440

ataatgttac ttatgaagga tgcaatggta agatttcagc aatcaggcaa gtatttaatg    16500

aaaagtattt ggtttcatat atattgtatt tgatttcata tatattgata cacttaacat    16560

tagaggttct aaaatgagta gccagcctgc ctgtttttct tgtgatatta tacttggcat    16620

actttgtttt tataatctaa agaagaggta ttaaaaaaag agtcagagtg cttaccattg    16680

gcagttcctt ttaacctttt aatttataaa gacattgcaa tcccaatgaa aataaaaata    16740

gaaattttcc catttggaat tagataatct ggatctagtt gggaaattgt acacacataa    16800

aagagtaata tctaatagca ccaaccctaa tacataatgt tattttatgc aaatagggta    16860

attaaaatag tatggtgacc tacatagata gttcattgga agaaaatacg atatccagaa    16920

atagacatag ttacatatga gaattataaa ggtagcatct taaataggtt gaaagaaata    16980

ttatttaata gttatcattg ggacacctgg gtagtcatgt ggataaaaat aaattcagat    17040

tactgctttg ccacctaacc caagatacat tttagtggaa tcaaatattt aaaataacat    17100

acaaaccaca aaactgctag aagaaaacat gtgaaggttt tgttttcttt tttcttttca    17160

cctgagatgg ataatatatc aatgtcatta caaggtttga gggaggaata tctcacatat    17220

gcatgtgaaa acccagtcat cacacttatg aagtacttga agtagaaatt attttctaag    17280

ataatataaa acacaggagc cactggagaa aggattggtg aattcaattt aattaaaatg    17340

tagatgcttt taaaagataa actaccataa accaaaagaa acaaaaacag caaacttaca    17400

aaaatatttg tattgtatac cacagaaaaa aagctaattt tattattttg ttaagagttc    17460

ctaaattaat aaaacactga tagtctatta aaaaagtgga caagactaca tacagacaga    17520

gcacagaaaa aaaagcacaa atggcatctg aggatatgaa aagatccctg acctcactca    17580

caaaagaaaa tgcaaactaa aatgataaga attaagaagt tttcggccgg gtgtggtggc    17640

tcatgtttgt gatcccagca ctttgggaag ctgagatggg tggatcacat gaggtcagga    17700

gttggagacc agcctggcca acatggtgaa aacctgtctc tactaaaggt acaaaaatta    17760

gccgggtgtg gtggtgggta cctctaatcc gagctactca ggaggctgag gcaggagaac    17820

tgcttgaacc caggaggcag atgttgcagt gagctgagat cgcaccaagg cactccagcc    17880

tgggcaatga gagagcgact ccatctcaaa ataaataaat aaataaataa ataaataaat    17940

aaataaataa ataaataaaa gttttattcc ccacttatta ggctcacaaa gatgaaaaaa    18000

aatttatgaa atactttatt gaaggtatgt gcaaacaatc cctgacacat tgtttgggga    18060

gagcatggat tgataggcct ttatgaagga gttaccaata taccaataac ctccttggta    18120

gtttcaaaag gtggcatctt tccctgtttg gtattggaga cccaatacaa gaaatgggaa    18180

agtgagcatc aagcaatgca agctttattc gatggccaaa gaatggagaa gtgcaagtat    18240

ggcgcacaag ctaacttctt gactagtgag gagtgaggaa attgaaatag aaagtatatc    18300

taatgaagaa gttggtcatt aagagtgagg ggaggaatgt tcatgtcttt tccagaaata    18360

ggtggtgaac ttcttggaac cagagtgccg ccttcctttt tgtcctttta tggcttcttc    18420

tggtcattgt catggggatt atcaactgtc atggcactgg tgggggtgtc atttagcatg    18480

aaaatgagat tataatgatg cctgaggtct tcttgaagtc ctttagtcaa ctatcttggt    18540

tctaagcaat ctcagctgct ctggttacaa atggaacatt ttacctgttt cttaaagatc    18600

agcagagtta gggtaggata gaaattcagc tatggccctg taggcgttac actaggtaac    18660

aaaagagaat tcggcaatat tttattatgg caaattaaaa acgcacatac aattatgact    18720

cagcaatttc actctgaagc atttgtctta caaataaaat accgtactgt gaaactattc    18780

aagagaatgt cctcacttat aagtgagagc taaatgatga gaacacatgg acacataggt    18840

gggaacaaca cacactgggg cccattggag ggtggagggt ggcaggaggg aggggatcag    18900

gaaaaataac taataagtac ttggcttaag accttggtga tgaaataaga tgtagaacaa    18960

aaccctgtaa cacaagtttc cctgtgtaac aaacctgtgc atgtacccct gaacttaaaa    19020

taaaagttac aaaaagagcc cacaaaagag taggttaaaa aaagaaaaaa actaatgaga    19080

agataattat tgtagctttg ggaaacaacc taaatgttct acagtgtggg aatgactaaa    19140

taatttgggt acagctgtac aataggactt tatgaagctg ctataaaaag aagtagcttt    19200

atacatgctg atacagaaag atttccaagt ctgattttta agtgacgaag gaaggtatga    19260

aacaatgttt atatagggta ttatttgcat gaaaagaaaa atgaatagat gtatacatgc    19320

tgataaaacc acatggatgg atacacaagg ggttggtact gtggttgtcc acaggggagg    19380

aatttggatg gctgggaaac attgaagagt gagagaatta tttttcgtta tacatacttt    19440

tgagttttgt ggctaaattt attcttcaaa aataaatata agaatgctat ttatggggaa    19500

aaaatgggag tcataaacct gcaatttgga cctaactttt caacttaaaa atgttctgtt    19560

cttggagtta ctaactgctc tgatgcttag gatgataatc aaataatagt tcctctaaaa    19620

tatgtctgga atgaacttga atgaatgaat gaatgaatgt tttttgcaaa ccattatgtg    19680

tgtaaaaatg tagagtatta atataaggtt tatttagaat agagtcatct gcattaaaga    19740

aacttcgtta tacaaaaatc taaataaaaa aatgttgtac agtagctctg aggaggtgga    19800

tgacccaaac actgagaaaa gaaaagaggc agaggctgag caggatagtt cagtttgagg    19860

taaagaagca gcctcaccca gcctcagaca agactccagg gactgtgtga aaaacctcat    19920

tttggccagg cgcagtggct cacgcctgta atcccagcat tttgggaggc caaggcgggc    19980

agatcacaag gtcaagagat caagaccatc ctggccaaca tggtgaaacc ctgtcgctac    20040

taaaaataca aaaattagct gggcgtggtg gcaggcacct atagtcccag ctactcagga    20100

ggctgaggca ggagaatcac ttgaatccag gaggcagagg ttatagtgag ctgagatcat    20160

gccactgcac tccagactga gaatctgtca aaaaaaaaaa aaaatctcat ttctaggcct    20220

atgtttccca gaaatatgtc atgaaaataa aactgccctc ccaatgggaa aacatatata    20280

tgcacaaaaa ggtaaatatt tttaatgtta aagttactgc ataattcctt taaagagtaa    20340

ttatatattt ctattcattt ttgaaaacca gttttagtaa agacaaagtt aaaagatgac    20400

aaactggcaa aagaaaaaaa aaagaaattt ttgtgaaaag gtatcaatat ccttagcgtg    20460

tgcacacaca cccacacaca cacacaatcc cttggcaaac aagaaaataa tgaatatttc    20520

aatagaaaaa agatcaagag actaaagaca ctgaccaaag aagaactaga aatgtttcac    20580

gaaattcaca ttttagataa aaacgtttta aatatcaaat tatgaagttt ttttttaaat    20640

gactatactt aacattgtgg gaaaatatat gcttacatgt tgctaaaaat gatatacatt    20700

tttatagcct ttctggaaac attttgtcag tatgtatata tatataaaag aagacaggtt    20760

gggtgtggtg gctcatgcct gttatcccag tgctgccaag aggcagaggt tgcagtgatg    20820

gagtgagccg agatcatatc actgcactcc agcctgggtg acagagagag actccattaa    20880

aaaaaaaaat tagccagaca tagtggtgca cacctgtagt cctagctact tgggaggctg    20940

aggtgggaag aacacttgag cccatgaggt ttggaggttg cagtcagcta tgattgcacc    21000

acagcctggg taacagtagg agacattgtc tctttaaaaa aaaaaatcag taattttctt    21060

ggaataggtt aatttcattt atttttttct atgcttttca gttttctaaa ttttctccca    21120

atgaaaattt gctatattta tattcaacca tattaataac cccaaattag tcacatgtgc    21180

aactttctgc aaataaatgt gtcttggatt taatggaaat gaaatctttt cagtatagct    21240

tctccctgtt atttgcgtac aagcttcaaa ctgcataaac tattttaatg gcaaaaatta    21300

agttagggtt aatcaaccat ctaggattgt atctgtgcct aggtttctaa aacaattaaa    21360

tacttgatcg ctttgttgga tgttcaaaga tttggcaatt tgtccttaaa tatatgtttc    21420

aaataaaata tctacaattt taaggtgctt aagtactggt gaacatgtca aaatgtgcct    21480

aatgtatttt taagttctgc tgtgaactta aaaactttgg gatttgtgta atcccaaatt    21540

agagaatttt aaactttagt tggtgtccac catattgtcc cccttttcat ccatctgacc    21600

aaacttttaa ccttcctgtt tatggctggg gaaaaaaaaa gctactttaa ttaaacctaa    21660

gcagatagtg ttgtttttaa attgtatttc gatgtcacta aaatggggaa acaggttgta    21720

atagcagaat ccttatattt tttgcacata tcagcctcca taaaaggatg gaaattgctt    21780

tgtttttcaa tgttttaatt tttttaatga ggagaaaaag agcaattgag agtgccataa    21840

attaaagata gcgtttctga tgtaaaatca atgatagtta tggattattg taaatgtttg    21900

aagatgctct tggaacactg aaaaatctta gaaaattttg ttaaataata attaaaattg    21960

tcttaaatta gtgtgacatc tatgttaaag gcaatataat tagatagcgt gcttcttcaa    22020

gtgcttgggt taggagaagt atttcaccat cttcattcat caagcattta acaattttat    22080

atgatgtgcc agatatcatg ttataccttg gtgataatac atgcctaaga caaatttcct    22140

gtctatgaag tttggaatct agttgaagga gacaggcgtg atgaaagaaa taaagcactg    22200

tagaagtagg ataaaaatcc gcatttaggg gactgctggc agctcaaagc agactggaga    22260

tatgggagaa agagaagctg atgaagggtt gaatttatat ttgagggaag gaaggaggcg    22320

aagtcagatc ttttcataca agaggtattg agccaaatat tacaaagcaa gtaatcaggt    22380

gatcaggata gttgaaactg ttcagataaa gggaacatta tgaggatgca gaaattatct    22440

agctgacctt tggggaaatt aaacgtagaa taatgtagct ggaatgtaga ctgcaaatag    22500

ggaaacagaa gaggctgtca gcatcaggtt agtaaaacct tctatgacag accaaagaca    22560

tgacaggtta ttctgtacat agtggggagc tgtagattat aatttttttt tagtcatggg    22620

aagattatca aatttcctat tgcagacaaa gggtctcttg ttcattgaat gaatattaca    22680

taatttattc aaacttgctt ggtgttaggc aactaaatgt tttaaggcat ttttttgtag    22740

cacagctctt ttttctcttt tttttttttt tggaaacagg gactcactat ttttgtattt    22800

ttgaagggaa ggggtttcat catgttggtc aggctggact tgaactcctg acctcaagtg    22860

atctgcccac ttcggcctcc caaagtgctg ggattacaga cattagccac cacgcccaga    22920

aagcacagat cttttttcaa aagaaatttg tgatgtttta ataagaaaga aattaaaaaa    22980

aaaacagata caatggaaag atatcgatcc tggaactttt aaatcttggt ttagagaaaa    23040

cagtttatta tttgaacaac ttcaaacact caagttaaaa agcactaaca aggcacatct    23100

cacttgcaca aaaatgatac caattatcaa ttgttggtgg caacagaatg gagcagcaca    23160

gaaatctgga gacccgtttt cagttgaatg ctcatagttc taaaataggc tctgatttgg    23220

aattccttgt cttacttttc agtttgatta acgtggaagt ctcaatatct tcttatgctg    23280

tgtgtaggaa aagtatcttg atcagtatat agaagaatat cccacaatgt tactgcaact    23340

aagaaaaaat taacccattg gagaaaacat ttttaatcag ttcattaaga gtctaatgaa    23400

ggtgcatata cgaaaagcaa gatgtacttt aattaatgat tgatgttttg tgattgaagc    23460

ttgctttcct aaataatatt tctatacttc agtacagaat gtaaggtcct tgctaatgcc    23520

ttatttggtt tcttagtttc agtcttactg cagtctgctt ttattgtagg cttattacat    23580

ttatcaccat cattaattta ccatggtgtt ttatcttttt aacttgttat ttagatcaca    23640

ttgtataatg ctttatttct ggtcttgtag caaaggaatg catacaacaa gcatgtaaaa    23700

ctttattgaa tagaacagtc tttaaagggg aatcatccat aagtcagata aatccatgag    23760

tagtatagat ttatctactg taaattttct gtcaggctgt taaaagtagg gccgtgtaaa    23820

tcttactgtc attcacatta taataggcac acttaccaat ataccaactt tatagttttt    23880

tctccccatt ttacgggttt agggcttatt ttttttgaga tgtcaagtac tattttaaca    23940

ttgtacgtgt ttcttaagaa acgccataga atgaagacaa tagggaagtc tatttgtgat    24000

atattctagc tcacttacat tttttactgt atcttacaac agtaaacata tcacactata    24060

cttgaattta aattttttca agtatcattg cattattttg cacataaaca tattcttaga    24120

tggtatcagg ttgatgatga tgagcttcat ggtaattatt taaaactcca taatgagatt    24180

tgtttccaat ctaatcaaga agggtaagaa tttggggaaa aaaaatctgt tctatagtaa    24240

ttaaagttag ccatatgggc acttggctct aaagacttgg atgtagtgaa tctacccaac    24300

ccccaagact aatgacttgg atggtcttac tgtattctct tgtccatagc aaagactgat    24360

gaatccagcc agggaattct ccaccagctc tgcttctctg aaaccacaaa gtcaggaaat    24420

gtaatcagag tgctcagctg aaccagagca agagctttcc taatggctaa ctgtgacttt    24480

agaaatcaca tccattagat aaagtgatta aatatacatc agtcttttgg caagagagcc    24540

atgaagatat tgcaatagaa ccttaccaca tgacccacat cttttgcttg aaaaagaaac    24600

atgttttcac ctttgacaca tatcatccct aaattcctca gctcagttgc aggaagcaat    24660

tttttcatga taagttgtat gcagttcata attttatata aaccataaag taattgtgtg    24720

gttgataaac tttataagga aaatgtttct gactttctca tttcaccacc ctgatgtgtg    24780

ggtttttgtt ttgtattatt cttcttttta ggcttttcat gcttcaagac ttcaagatat    24840

tttgttaaat tcttcccttg gaagcctttg tgtcgccaaa tcagattttt ttaaaactta    24900

gatatgaatg tcttaagtgt ctacttagga aatatgtgtg tatgtctgtg tgtgcgtctg    24960

tgcttatata tagagagcag gcaaattact cttagcactc tgaaaaagct ttttttgtta    25020

aaataatgtt ttaaaaatat tataaaaaaa gtcaccgtca aaatagcatt cgctttatat    25080

ttgtagttga aataattcct gtttcttact cttagttata accatctttt gattaataat    25140

atactgccct tcacatttta atacacatgc aactaagccg ctgatgtaat acatatactt    25200

aaaatgttct ttttgagctt tgaataacct tttgcctttt ccctggtgat caccagtggg    25260

caagatgatt gacagagaat gtgtttacaa acatggaatc attgatgact aagttaaaag    25320

tgacctcata aaatatagtt ctaattctta tttacagaca aaattctaag agctcaattc    25380

aatgtgtcta ggataatagt gggcatagtt aaataaataa taggaagtga ttatcattta    25440

caaaatttca ttagtgaatt actaaagtat acccctatgc atactaattc ctcttcccca    25500

aatcaaaact tctcatattc ttaaatttct gaattcctaa aatcagcaga gatgaaggga    25560

tggaccagca actataattt tgttgtgttt tgtgtttctg aggcacatat agggatacct    25620

agtttcatga aaccaagtgg tggggacatt acacacaaag agaaagctgt taaaggcaga    25680

atgcccagac aagaatgaaa atgaaattcc tggaggggca tccccatagt ttttctgata    25740

atctctctcc ttacataaaa agcttgaatt actggtaaat tatccatgca ggaataatag    25800

aatcatagaa tttttgtagt ataaggaatt ttattgacat catagttgaa agcagtcatt    25860

ttgtaaatgt ttttggtgcc cagagatact ttaattatgg cagaggaagt tatagacaag    25920

tccacgaacc aggagtagaa aagttttcaa atgagaaata ttgcagacca agcatgttaa    25980

ttttatttta ttttttattt tttatttttt attttttttg tgagagggag tttcactctt    26040

gttgcccagg ctggagtgca atggcgcaat cttggctcgc cacaacctcc gcctcccagg    26100

ttcaagcaat tcttctgcct cagcctcctg agtagctggg attacaggca tgccccacca    26160

cgcctggcta attttgtatt tttagtagag acagggtttc tccatgttgg tcagactggt    26220

ctcgaactcc cgacttcagg tgatccacct gcctcggcct tccaaagtgc tgggattaca    26280

ggcgtgagcc accatgcccg gtctgaggta ttgttatata cacggcaact ctagccttat    26340

aatgcattgc ccttatagtc tacttagggt ttttaggaat attgtgacct aatttaaaag    26400

tttgtagaga gattctaatt ttcagaatta acagtacttt cattttctct gaccattgaa    26460

atactcctaa attgcaaaat gaagtggaag tacacagtag attagtaaaa catatggttc    26520

aatgcataaa ttgaaataaa taaaatgaga ctatttagaa aatgataaca aatacaacag    26580

taaaaagaac tcattacata actttgtgac ttttttcttt ttctttcatt ggttccttac    26640

attttgaact ctttctcact ttttctgttt ccttcttttt aaagtaagga atagagaaag    26700

agtgtataca actgaataag tatttattga ttaccttcta tgtaccccat tgggctaaat    26760

atgggagtag aaagatgaat aagatggtca cagcttgggg gagggtgatt atgtcaaatc    26820

atgatgagag gagttttttg tttgtttgtt tgtttgtttg tttgttttga cggagttttg    26880

ctcttgttgc ccatcctgaa gtgcaatggc gtgatctcgg ctcaccgcaa tctccgctcc    26940

tgggttcaag cgattctcct gcctcagcct tccgaggagc cgggattata agcacgcgcc    27000

accacgcccg gctaattttg tatttttttt agtagagatg gagtttctcc atgttggtca    27060

ggctggtctt gaacttccga cctcaagtga tctgcccacc tctgcctccc aaagtgttgg    27120

gattacagac gtgagccact gcacccggcc actactttgg aggtttaaga aaagtagttg    27180

taggtttaaa actcttggac tggctcctga gggaagaatt aaaatgccct attggagcat    27240

agccacctat ctaggatctt gagtcctaga taggtgggtg ggaatgagta tcaggaaatt    27300

gggctgggac cacttaggac aggcccttgt gggttaatcc cataagctat tgagaagcca    27360

ctgatgattt tttaacagaa gagagatgtg atcaattttt aattaccact ctgacagtac    27420

tatatattct gtggataaga caaaatgaga gtggaaacct agagacttgg agaccattgt    27480

gatagtacag ataaaagata aagagaaaaa gcaaagggaa agggtttagg gttgatttag    27540

aaagtataat caatagccct tgttgattag atgttactct attctgagtt cccagggagt    27600

aaatggtact ttttattact agcactggct actgactggc aatcatttaa atgagcgggt    27660

taaaataaga gtatatgaaa aattagagtt tgtggaactt gaggggcata tctaggctgg    27720

aaaatagcta cttgtcattt ttttttttta atgttggaag actttctatt cttagtttgt    27780

aggaaaaatg tacatgataa tcaacaaacc gttacacatg tgctaaggtg gtatattaac    27840

taattttcat tggctcatga gttacatgct acctggcatc ctcttgcctc ttcctctctg    27900

gagccacaga ttgttagcag agaagctgga agaacctacc atcttgccat aggaaaaagg    27960

tttggtcctt ctggaacatg cctgtgaaaa gttgccaatt tcctatgtag gtcctggact    28020

tatctggaat tcaaatatga ctagacacca tgtattttat ctggcactcc gatcctatgt    28080

gttttttttt aaatatttat cctcctttgt ctcttcatga ccttattata caagttctag    28140

atcagagtgt aacagcctct ttaaattctg tggcatgaac tttaaatgcc tgtgaagaat    28200

ggggctgggt tacgattggc taccagtgaa ttccaggtaa tttagacact tcctggattt    28260

gttttccgtg tcatcattta ttgattactt catataaagt cttaatgtgt ttattactca    28320

ggaaaaatga tggaatagta gcagcaatgc cacaggtgtg ttgtgaacat taattagtta    28380

attacaaagc atttagttga gaggcattct aaatagcaca gaactcaagg ctttcctccc    28440

caaccagggg tccacttaaa tagctcttta ctaagtcagg agaaacaaac acatcttgta    28500

catgaggtac atcaaccact aggcatgttg atctcccagg gtgattttct gcatgaaaac    28560

ctatcccctg ggtgtcaaga gctttctaag agcaatgatt catgaaccct ctggatttag    28620

gacaatgcta tgaaattatt ttcatctgta ttctgaaata attacttgat gtcctattaa    28680

agtattttat attttttgcc agaagttgta ggtgtaattg gaaacaacag aatactcaaa    28740

aaaataaaag atcccaaagg agaataagaa gaaagagaga gaggaatggg ctataaagac    28800

ggcaagagtg atggaccagt gcctaaagat tttagacaga ctctcaaatt tactcttctt    28860

atgttctctc taaacaccat tcttattagt tcagcatcac tgtaataact aaaaatattt    28920

taaaaagtgg acaaggcaga tgtcagcaaa ttgatgtgga gaaatgggac agacacatgg    28980

atgactcact cccagtccca attccctatt ttattttttc atttgaaata tccatctctt    29040

cagagttctg tctagtgtga ggttcaaaca atttaaatgc ttttctcaaa actattgtgc    29100

aaatgtctgt ttttctgtat ttttgtgtct ttctgatgtt cctctcctgg cttttcacct    29160

actatcacaa attacatact ttattatgta cttttatata tcatatactt ttcaatgagc    29220

ttgattccca cctgaaccca cgctttagag agaacaatga taggtttctc tgcacctgct    29280

ccatatttag taagtttcca attccttttg gtgtcaaaca atagcaggta tctctgcagt    29340

cccttaggtc actaatgtgc ttggttttgt tgtcagggta gcagctgaac catatctttc    29400

acaaacagga gatacatatt ttttcccagc ttgagcagag catctcacat ttattaggag    29460

aaatgcccct agaggcccat ctgtgtgtct ttgacggctc aagtattatg tactttaaga    29520

agtttaatac attttctact ggacagtatt gagttgtttt aaaatattaa aatcttactt    29580

tgctgagata aataaaaggt attcaggctt ttccaagaca agtatgagaa atgccaagtt    29640

acaacaggtt cactaatgag ggagaagaaa agtttcatga taatactatg atctttgcta    29700

ttgcatttgg aatttagtta gacctaaata atgagaagac ttttgtgatg atctattcaa    29760

tttttatggc ctatggtctt tttgagaaat tgattaaggc aggggaaagg ggatagtggt    29820

agggcatcac tgactcttgt tttcttgctt gtttactctt ttcacgaagt ggtaatacaa    29880

attacctccc acagcagcac aggttactca aaagcccaga ggagcaggag aatgagacat    29940

tccttattca tatttcagta aggtattctt ctccatcttt gttgtttcaa ggcagatgac    30000

aaaatttagt agccatttta gtgcagaata ctcccaaatt cagggaggaa gctagattca    30060

gttgtttttc agtaatattg gaaagtgtaa tgtgtaatgc ccatgtttaa acagttgctt    30120

tcttcctaac atgataaact tctatcgtta gaagatattc tcttgggatg aaaataaaaa    30180

gatatagcat aggccccgtt tattttattt ggggaggagg tagtagtagc ggaaaatata    30240

accagcgata ccatcttcat tactaatgat gacaacttac aacatcagga gctcaggaag    30300

aaggaaagca ataaatacct tcatcttcaa caggattttc tggcaattat atctgttttt    30360

gtttgtatgt ttgtttgttt tgtcctctat taatttgaaa tgcctagatt gtttttctgg    30420

aacttagttt tatatcaatc aataaacccc ttttccctac ttttttttgt tacttttttt    30480

caagagcata ctgacctcaa cgtggtgaaa gttttcaaaa gaggcggata taagcttaaa    30540

acctgcctct gcccactcct gatctatctc aaatgaacat ctgtaactct ccatgaatta    30600

aaatgaggat aataacatgt tctaattgtt atagaaaaaa ttacatttgt agcacagggt    30660

agctgcttta tgcatatttt tttctaagtt atgcacacca caattcagta ctaattttgt    30720

catgatgtcc tgaagaaatc ctaaaaatag agattctgtg aaagaacatt gagtaccaca    30780

taatcaagat atatatgtct tgattcattg attgattcat tcattcaggg cattatatag    30840

cagtcatttt tttgctaccc ttccacatgg atgatagtta aagactctac tgaagccact    30900

agatacccat cttatacaca ggctgtaata ttttaactcc tggagtaatt ggggtatatt    30960

cacaataaaa tcagctcaaa tctaatttat ttctttcatg aggtctgaaa tgtagtcaaa    31020

gcttccattt agttcctcga gaaaaagctt ctggcaaaga taacaaagga catgattcaa    31080

atgctttctg tcttacactg ctgcttcaca tcaggggcag aggattttat gtttcatggc    31140

cttctcctcc cacatatttt gggttttctc atctaatcat acagctatga tgtcagtgat    31200

ggaaatttcc acctcttagt ttggtatctt gattgttttt tctttccctg tttgcacaaa    31260

ggattgtagg tggctttcca gaaaagagac atgaaaagga tcactaaaag gagcttcaaa    31320

acaaattaga ttatttgttg tggggagaaa aatcatagca gcaggaaatt tcattgtgcc    31380

ttttacacaa gatctaacat gctgatgaat tgctagtata atgatgattt atagagctga    31440

gtttcttttg accaagccca gtactcttgc aaggttaaac aattctaatg gcggatgact    31500

tgaaggacta ttttctaagc gaatgtacaa attacaagtc cttagtttcg taagatgctg    31560

tttcatcaaa ggcttttctt tgtggtttct catatttcat attcatgttg actcccaggt    31620

gatagttaat ggtatctttt ttagtagtgc tattatcagc ttcaaatgaa ataatagata    31680

ataaaaagcc ttattattaa tgtcatattt tgatatattt ttaactttat aaggcttttt    31740

agtattatta atgtcatatt ttgatatact tttaacctta tacttcattt attctaagta    31800

atgtgatgtg atcaataatt tttcaattaa gtacttttct ttttgtctgt gctagtttag    31860

tttagttgat tggaatatga tgttactgta actaaagcaa agtttggatt cctgtaaaaa    31920

gacttagcat ttctccatag aaaggcatat gtacttttag ataattctcc atgatcctaa    31980

tctgttatct cacaagtaaa gaattgacac ttagcatttt gagatttaat atgtattgag    32040

tggttcttgt gctttgcccc tctactcact ttacattata aagcatctac ataaaatgat    32100

ttgtacatta tctattgtaa tgcacacaat aatataatga agatggggat aattgctatc    32160

tccacttttt cttttctttt cttttctttt ctttttttga aacacaatct cactctgtct    32220

cccaggctga gtgcagtggc acagtcacag ttcactgcaa cctccatccc caggggctca    32280

agcaaacatc ctgtctcagc ctcttgagta gctgagatcc actcccctcg gcctcccaaa    32340

gtgctgggat tataggcatg agccatcaca cctggccttc cactttttca atgaggaaac    32400

cgtggtttag agaagtaaag acatgttatc acatgcaaca agaaaaaaac agaactgcaa    32460

ttcaaatcag gttctttctc atagttctta ataccatcct atagtcctca aaccaaaggt    32520

tccctcttgc ttgactttga gatgatgtat agaatcactc ttgaaataaa ataaatattt    32580

tatttaattt ttttcttttt cccagaaaag taatctagta ttttgtatca atcaaaaact    32640

tctattttga aaatacaagc attcctagtt ctataaaata tcaacatatg taaagtctcc    32700

taaaagcttt gggtttttat atgtgaagcc tttacttctg ttttcttttt gaaataaaac    32760

attgattaga attctaaata ggttatcaca aatctataat ttttttccta taaaacaagc    32820

aaagtatatg acaaaaaaat cggtgctctt ttttcacctc accaagaaaa ttagtgtaat    32880

tatttcatat gaataagact ttttacctgc actacattat ttagttaatt ttacaggctc    32940

tagaaagatg ttatgcaaga gaagacattt caattaatct gatgttgaaa gaatgctagt    33000

tttaaaactc aatgcactct atgtgctaaa aacgtttttg cagcatgaag gtagggatgg    33060

acagggacat gtttgcctga gttctccagg gaagctttgg tggtggatgt atgcaaaggg    33120

cataatctgt ggtttccaaa gttgaatatg cacacctaag aacaatgctg gaagagcttt    33180

gtcttcattc ttatctttaa aagtttcaat tttattcaag atcaaggtaa tgatagattt    33240

aaaaaataat gataaaataa aaaatagttt caattttgtg tatattttta aatgcatatg    33300

ttttacactg catgtgtaga ttgtttataa tttagcaagc atataaattc atttattggg    33360

agatctttta ttattattgg tattgctatt attgagctgg taagggtgat gatcaaaaat    33420

aattggagac tctattctaa acgtgaggta gaaaattttc tctgactcta atggtttaat    33480

ctttaaaaaa cagtttaagc cacactataa ttaaagccat aatgtttgta acacttaatt    33540

ataaggatgg aaaacttggt cctatagata ttatcacctt aaggaaaggc aggaaagcta    33600

actgcagtag ttgaccattg gcacattgaa ggggtcatga ctggcctgca gtgtcaaaaa    33660

gtgaccaaac agggacatct ccatatggca ttcattgact agattggttc tattactgat    33720

tgaagtcatt tgtgtttttt gtacaaactt taaatagccc aaagattcta aacgatttta    33780

aagtaaatgc aatatattat tagtattata tagtctatac atacgtgctg atgtgtttgt    33840

gcgcttttct ctatttatag ggcatcataa tttctcaaat ataaggtata atataatcag    33900

gacaagactt gggaacaaca tagtatacat aataatcaca tagttattat tttgacaaac    33960

atttatgcca cacatgcaga aacacaagtc tgcaaccctc cctatgtatt gacattattc    34020

tgcaagtatg cttacaaaac aatataagag agatcagaat atcctagtat tcttaaggtt    34080

aaaaccgaaa cctttcttgt atttcctgaa tgaaatgaca gattaatgtt attgatgaaa    34140

tgaatatggc ttggcttcct tgagacacag gctgttagta aaaaagcaat taagaaaata    34200

ataaagaaat gaaacagcaa ttcctcttcc tttttccttt cttctgtact gtgtcatagc    34260

aaaagtaata taatagcaac taattatagg aaatctccca gactttgtaa ttggatcttt    34320

cattttttcc cacagcaact gtgaactaag aatttattca cagagcagct gtagtttgtt    34380

tccagtaact cttagcagtg tctctttgtg gagtcttaaa gagacccatg tacatattta    34440

ggcatattgg ctaaactagt gccttttaaa acatctgcag gtctattgtt gccaattctt    34500

tcattgtctt ctatcaaatt aacttttctt agacggtata aagtgggaga agccactgaa    34560

ctcaaagctc aaagcctgac ttctggtcat agcttcaatg tttccttaaa catgacttgg    34620

taacaagcac caaactttgt aaatctcaat gtcacctttg gtaagaaaaa tgaaaggaat    34680

ctttgcagtt tatattttag agcattgcta tatgtgaaag agctgtgaaa attataaacc    34740

agtgtaactc accatgtcat tatatagata tgtctaagtt attcttgaat gtgaaatttc    34800

catttgcttg acaaatgtca ctctattaca tacatgatag ttaaaagcat cttattttcc    34860

atttgttccc cagcccagtt ttcaactttt cttctaaaaa ggtaaggtca attaagagat    34920

atttccaaag gaaatagttc tttagaaaat actttagtat atcaatgcac ataataatac    34980

aaagaaatgc agttataaaa ataaaatata gaataaatac acagctacca tattcttggc    35040

atatatttgt acatgaagaa ataaacttca aagccaggca ggacggctca tgcctgcaat    35100

cccagcactt tgggaggctg aggtgggtgg atcacttgag cccaggagtt caagaccagc    35160

cggggcaaca tagtaagacc ccatttctat aaaaaataga caaaacttag ccgggtgttg    35220

tggcgcctgc ctgcagtcct agctacttga gaggctgagg tgggagggtc acttgaatcc    35280

cagaggtgga ggctgcagtg agctgtcaat gcactactgc actacagcct gggtgacaca    35340

gaaatacact atcaaaaaag aaagaagaga aaggaaagaa agaaagaaaa agaaagaaag    35400

aaagaaagaa agaaagaaag aaagaaagaa agaaagaaag aaagaaagaa agggaaagaa    35460

aagaaaggag agagggaagg aaggaaaaga aagaaagaaa gaaaaaaaga aagagaaaga    35520

aagaaaacgt tgtgatatga ttagaggact aagtcttaac gattagaagc ctgattttta    35580

aaaaattcaa aaaccaagaa tcagtagtag tagttgagaa agtaaaactg agtgaaaagt    35640

agttttgcaa tcaatgtgga aacactattt ggtaaaatgc acttgtactt gaccttcaag    35700

taatagatat gtcaatgtta aaatggcatg ttttgaaaga aaacccatgt caaatagtcg    35760

atataaatta tagattatat ttctcagata attataaatt ataaaatttc tgagtacatt    35820

cttcccaaga tgtgttattt gaggcttttg tcttcactca ttttcattaa ggagactggt    35880

ttcccatttg ttttctcttt tctttgtttt caagctgtaa tactgtagag taaaccctag    35940

ccaggtgctt gtcctgcctt acttcatccc ctctttctaa cagactaccc gtgtaacttc    36000

ctcaccagtg aaataggaga catagttcct gaggttaaat catttactca ggttcataca    36060

agagtggtaa agccaacatt tggacttata atttcctaca atatgctacc tctctagata    36120

gtagaattaa atttcaaaga gaaatgtcag gagaaattcc atattctaca ctaaggttct    36180

catctatttt attttccacc atattattac atagaagtta tttaatttaa aagtctgatt    36240

ttaaggtaac ctttatacta ttaactctcc tccttgaagt gctacattta caagtaatta    36300

acaaatactg tttgagcaag cacttgttca ggtgccaggg actccagttt ttgttaattt    36360

aaatatagat gcttgatatc atttattggg gtgaaagaga ataaaacacc ttctcaccca    36420

ccttcctaaa ttcattatag ttaacagagg gagtctataa aaatactagg acatagggac    36480

tcattacatt ctaacaaaat tctaagaaca tgcatgtctt tccccaggca tttagcttcc    36540

cctccctcct cctatttttt catatcttaa agtaagatct aaattaaaaa tttagaaatt    36600

cccaaattat gttgctgttg ataaaaggcc actacatgtg aaatcagcct tttctgtgat    36660

acattatata tcagagagtc agctattact tgtttgtgcc tttaagaaag ttaagaccaa    36720

cttacctgtc attttaaatt tgatttccga agagcagtgt gccagaaatt tggcttaaac    36780

agaccaacaa agcgtggctt ctaggtgttc ctgatgggca ggcttttttc aattaacttc    36840

ctggggattg ttttatttaa ttacaaggac agtttaccag ataaactact cactgattga    36900

atttctaaac tcaagtctgc tgaataaagc caaatgagtc atcgataaaa attcagatgc    36960

caagaccttt gcaacaggta catactctaa gccatgtatt tctgcatttt aaagttttaa    37020

aacatccttc ctctaatgtt atcttttttt tctatactgg cctggggagt aacagatctt    37080

agttcaaatc ctggctctgc tacacacagc tgtgttacct tgagcaaagt atctaattcc    37140

atagataacg ctttagtttc cttagttgtg aattgaaaaa ttcagtgaac ccaagttgag    37200

acgcattcta caaaataact gatttgtatt ctgcccaatt gtcaggtcac gaaagaaaag    37260

aaaacaattg aagttctgtt gcagataaaa agagactaat gaggtataac aactaaatgc    37320

aataaaaaat gatgtaattt aagtaagatt tgcaattcag atagtaatat catactggtg    37380

ttaattttct tgattactat ggttatataa ttgttaacat tataggaagt ggggcagggg    37440

gtacaaggga atatttagta ctatttttgc tcctttccta taattagctc acaataaaaa    37500

atttaaaaaa caaataaaag ttatggagag aggagaagcc aacaaatagc ataagtatag    37560

aactgttttt gtacacatgg gcgttagaca gatagtaata gtaatatctt gtataatttt    37620

aatataaaga gcaccgaaag agaaaaaaaa ataagcccta aatcaatgcc gagggtgtca    37680

tctttctttg gaaccccctt aatgcagtga ctcctgtaag tgggcatgtc cctttcatac    37740

agagttgcag ttgttacaat tgataagggt tcatgtgaga caagcaattt tgaagcaggg    37800

caactcccac aactgctcaa tgtggacctc atctccttgt atttgcatag atatgctttg    37860

ctgcatggat tgctgcaaaa ttgctgaaaa gactcccata caaggagaat gcctggcact    37920

actcctccgt ttgaaagctc tggtttctct cttgtatcct gggaagagtg ctgccaagta    37980

gtccatagac ctcttcttat ttccttaact tgctgtgtac attttgaagc atttatgtgt    38040

cagtttattt aactccccct gcctaataat gataataaca ataatagagg tatgtattga    38100

gttcttattg gttcaagtat gattctagag tgtttatatg cattaactca tttaaatatt    38160

caaaatcctt ttcatactca ttttaccgat gagtaaactg agatacacag ttaagtaact    38220

taactaaggt gacctagctt ttcagtgttg gagtctggat taaaaagaag gtagcctggc    38280

ttgcactttt cagcctttag aaatatacat acgaccatat ccatctgctg aattccaact    38340

caactttcct tctttcctat accagctcaa accaatttct aaccccttgt gtttccaagg    38400

tacttttaaa atacttccat tcaagctgtt ttgccatgtt ttgtactatg atcatttatg    38460

tacacgtctt tcttaaaaac cattagcctc ttgggactag gaatattcct gggcaatgtc    38520

aaaatactct ttatatgctg gtgtctccaa agttactatt tccaacccag cctcccattt    38580

taagttccag agtaacatgg ttagctactt attggacctg tctactttgt gtctcccagg    38640

catctcaaac acaggatgtc caaaattgga tttatcattt ttcttccctg ttctttaagc    38700

ctcatcctcc tagtttcctc tcataagaaa tcactggagt attaacttgg caggccaagt    38760

cagatacctg aaagtaatct tggatgctca tctcacttct ggaatcccga gttcaactgc    38820

catttccagc ctttcattat ctttcaaatg taaccacata cctatacctc aatatgtttc    38880

cataccccca ccaatcatat cagttttatt cacttggtaa ccgatctttc tgctgtaaat    38940

ttaccctcta gactatgtga aaagtgagtt ttacaaaata tggacttgat cattttcctg    39000

cttaatctct tcaaaatcat acatctacct tcctctggac cccctttctc tccactttct    39060

ttgttaagga aatagtccct taaaaataat gaaaataatc agtcaatatt ttccaatgag    39120

ttagtgtcaa tgcccagggt ctacaactca gcacaggtat cctttattaa gtgtactata    39180

aaaggagtac caaagcttag agcttaatca ctggatgaca ctggaatgat tacaactgaa    39240

aacagttagt gattagcctt ggtggatata ttggaagcct agaatacctc tcagaagata    39300

tagaactaaa aacccagcca gcctctcagg ccgtttacag tgtaaacaaa gcaattagag    39360

ccaaaggagc aagtaagttc taaggaccct ggcattgtta aatggaaaaa gcctccaggt    39420

gaaattgtgg tctaagcata ggtttctcaa cctcagctta atcgattttg ggggcattcc    39480

tataggaact ttagcagcct ctctgtcctc tacccaccag gtgtccatag caagcaccct    39540

tcttcctcca tgttcccatg agggaggaga gtccgatatc tatacagtat atgaaactag    39600

gaaatgtatg taatgatttt gtcctgcacc ctttattggc tttgtcaaga cagcctaaat    39660

ttcctgtatc ttagcttttt tcaataaatt acaaaaattt gacagttgga gccatttttc    39720

tgcgacagta attggtgatt aaatcgctta aatgccaaca ttagccaaaa tgtttacctc    39780

tacaaatgag aatctttaca atccctatcc tctttctagc aggtttggct aagggaacac    39840

caaaagcaca ggcagaaaat tacaattaca attgtccctc agtatcagtg agggattggt    39900

tctaggacct catgagatac tgaaatctgg agatgctcaa gttctttaca taaaatggtg    39960

taacatttgc acataatcta ttcacatcct accgtatact ttaaatcatc tctagattac    40020

ttataatacc taatccaatg taattgttgt tattctgcat tcattaggaa ataatgacaa    40080

gaaaaaaaac tctgtacatg ctcagactgt gcttattttt catattcaag aaaggaaaag    40140

aatggtcttt aagcccaagt ttcaagttgt gaacaggtaa tcatcattat ttatcattaa    40200

ctcagaatca gtacacaggc tctgaaaatc agctaaatct gtgaaattct cattccagtg    40260

gccatgtttc tgaaaataaa ccagtcaata actgcctcac tccagtaact atgcttctga    40320

aagttagcaa gtgaaggcca gtccaagctt ttgaaagtct gctaatgata aactcccagt    40380

cccgaacatc accctgtcag tgcctgcccc tatggtgcta gagaacagcc aatcagtaag    40440

tgtcccactc tagtgaccat gtttccaaaa tttagaaggt caacggcagt cttactccag    40500

tgtccacact aacacagctg gaagtccttg agtctctaaa cactctgcac atttccccaa    40560

accttatata atgtcagctg tggctttgtt ccaggaactt atctctcaca aatacagttc    40620

tctcttgctg gcaaacagaa cgtttagatt tttggcatcc aatatttagt tcaatttact    40680

gtaagttcac aagtttgcaa tcctttcatt ggctcaactc ttgtttatgt ttagttatga    40740

gtttgtacct gtgagtgact gacagtgaca aagctgtgag attatcaaat tcaatctttt    40800

caattcctgg gtcaattact aatatccatt ttttatttgt gtagaagtaa actcaaaaat    40860

gtcaaaatgc aagtaagttt tgtgataaat tttatgaaca atggatgtgc attaaacaaa    40920

gaaaaactcc ttttgaagct ctttgtgcag catacaattg tttagctaat attgaaaatg    40980

gtgaaaactt ggatgtaagc cagcaaatac taacagctaa gcaaatagat gtatgatttc    41040

ctcaacttgt accaaagaaa gtaataaaat cacatcttat tgaaagaaat tcagatgaag    41100

aagataaaat aattgcagca caagttgtct tccactttgt atatcataca aggttttaag    41160

ctcacatgac ttaatttgaa ttgtgctaca agtatttttt aatgcaaaat tgtaagtaaa    41220

ttttctagtg ctataggaca aaatctactg ccgtaataaa aattagaata actccattta    41280

ctgttacaga gattaccaca gctcaaatgt tttacttttt tatggcatag ccatgaatgc    41340

aagtaatcac aatttggggg aaaaattcct ttactcgtat aataattttc tcataaaaag    41400

acttgcttac aaggctattg taacacgcct tccagatgag tcttcagaaa caacaagaaa    41460

ttgttgcaga gaccctatga ttgagttagt agtcataaaa attatactta ttttgtggag    41520

gtaatacaaa tataaattgg tggatatttg cataaaggtg tgatatttat tgaaagttaa    41580

agcaaagtat aaatgggact atgaacagtg ttgcctcttc tgccatattc tacatgacgc    41640

tgctcaaaca gcatctgata tcagtaaagt aattgccagt aaagaaattg tcaagaaatt    41700

attctatttc agcatttatt ctgttcagac tctactaatg aagaattttt gtaattttgt    41760

tggcattcgt tattttcagt tctttcacat tttaaaattc actggctctc tttaatagat    41820

gcagttgaga gaattcttag tttatttaaa gcaccgaaat catactttaa ttctgaagaa    41880

aaggtctcac aaattcttgc tgacttttaa aataacccat tgagtaaaga ctacttattt    41940

cttgctcata gcattccata tcttttagca ataggattat gcaatttgaa agaagagtaa    42000

acattgttaa ttgatgccct ccattgctta caaagagttg ttgaatgtat taaagataaa    42060

atggatgaaa agtttatccc ttgtatgcca aggctgtttt aagaggaaca acacaactta    42120

gggacaggga aaaagtccgt attgaagtgg ataattattt ttacatttgt catgagtata    42180

ttttgaaatg tattttatcc cttgaagaat ttgatccttt aatggaacag gagaaattat    42240

atgcactcaa agaagggaat aaaaattcat gacaatgttc tgttttgtca gtggaaaata    42300

tttttaaaag ttgtagatca aaatatgcaa tctaatcctg aaaaataaaa aaaaacaagt    42360

tatgtcatga aatatggtat tgtgttcttt agcaaaagag taagtcccag agttaacttt    42420

aagtcaatac atgttcagaa gtccagctta taaggctaac actgaacatg ttcaataagc    42480

tggacttata agctggactt cacgatgttc tcattaatga atgttgaatg gagaaaagag    42540

aaaatttgga tgtgaccact atggaagaca tgttacattg tagggggaac ataggcttta    42600

actataagga attttataag tcaactctgc aaaacaagga gctgttaatg aaagccaatc    42660

atcgaggaaa ttttcagaaa agaaatctct aatttacata ctgatcattt attttagata    42720

aacaattagt aaattttaag attaagactg ttctgtaaaa acatttccat ttatggtcag    42780

aatatgtata cacaatgata aataattcaa atttaactga ctgtgtattc tttttgctaa    42840

ctctggtaac tccacctgga ggtagggaag aattatcctg ttgaggacca ctggtttaga    42900

ccaagataaa atattatagc attcttacaa ttattattta ataactttat tatactattt    42960

atatttctta aaataaatat attcttggat ttgccatatt ttcttgagga caaaaatatt    43020

tttgaaatat aataaaatat aattttaaaa gaaaatttaa ttttaaaata ttttagagta    43080

ttgaaagttt gttttattgt agtaagttag catcatcagg ttgcttatgg aaggcttatg    43140

gtcctgcaag attaaataat ggcttggttt tgttatattt acatctgtga tttcattttt    43200

aaaaactaag aataatagtg tagaagatat aaaagcagtg tgtatattta aagtgaattt    43260

taaggacgga cttagtccaa aataaaagtt ttggactgtg gatattgcag aaatattatt    43320

aataaagata atgagcaaaa tcatcatatc tattttatag tataagaagt aatatgatag    43380

gaacaatatt gaaatggatt ctgcatttac agactgcatt atgtttcttt taaatcacta    43440

cttctgaggt caagtgatta attttcaagt gattcagaag aaatgcttta atcacttagc    43500

aaaactgtca tagccaaaag gagcttgttt tggtcataac ctagttccca caaagtgagc    43560

caaaagtaat ttctcatatt aagcaaagat attgattaca agcaagagaa acaaacactg    43620

gctgtcccaa gccaaatgga gatttattgg aagttgttgg gtactcatgc attcattgga    43680

aggctttggg aaactagagc agctgtatag gaaaatgagc tgacaaaagg gaaatctaga    43740

ggctgtttgg cagacccagc tggctagact actggtcact gctgccacac aggattctac    43800

tatagctgta catagaccca gcacaaggga atttcaataa aatcttcctt tatttggctt    43860

cattcaccaa gttcaaagta aagggcaaca gaatccattt gaataagctt aggagatgat    43920

ggcctcacca cttaaaataa caggagtgga atggaaatat agtcacttta gtcactttag    43980

ctttccacgg caggtgtcaa ggctctgaat tccatcacca ctacacacaa tgggaaatac    44040

ctgttcattc tagataagaa ggaagattgg atattggata gaaaaaaaag tagacatata    44100

attaggtcat atcatatgac attctttgtc atttttgact ttttatatta aagtagtgat    44160

ggaaagttag tggaatatga aacaaaagtt acaaggatga gcaataaaat aaacagaaat    44220

tatattaaca ttgagcaatg aactataaca aagttttgtc ataccagaag caaaagtaaa    44280

aagtattatt tctcaaagaa gaagacactc atctcttata gcactattaa ataaattctt    44340

ggattgtgta ataatccagt ttataaagaa gagtgaatca tatgaatatg ttgaggaaaa    44400

atattaggat gtcttgctca tttgccataa aatggccaaa catgttgaga taacaaactc    44460

ttcatacatc actacattga ggatattgat aacagagtgg ttgggtgttg tcgatttaga    44520

gtatataaga ttagcttctg aataaggaca ctgtacaggc tctgatatct tacaactcat    44580

atgtgaaaga aacttgatgg aggtgttccc aaatttgaca gtaatactga aaattttcat    44640

gccattacca aaaacaagtt gtaaaactca gagaaatttg ctcaactatc agtaatgaac    44700

atacacacac tatactcagt tgtggtaaaa gaaagactaa atttttctat cttctccatt    44760

acaaaattga tacaaagtaa agggaagatc aaagagaatg aagccaaaaa tgaagggaag    44820

tcctaaagaa atgtgttaag gagtaaatta ataaaatttt ggaatttatg gtattggtta    44880

attattttta atacagagac aacttattta atttttgttc tcacttttaa taaacattca    44940

cttttatatt aatctgtctt ttgtgcctaa tttgcccttg tatttttgca ttttttctca    45000

acctcctccc ccagttgtat aagccacaga tccataaaac ctggatctgt ttataggcca    45060

cagtgggtta gatcaggggt ttccatcccc tgggccagtg acagatactg gtccatggcc    45120

tgttaggaac caggctgcac agcaggaggt gagcagcagc ccagtgaaca ttaccacctg    45180

agttcttcct cctgttagat cagccttggc attagactct cagagaagtg caagctttat    45240

tgtgaactgc acatacgagg gatctaagtt gcacactcct tatgagactc taactaatgc    45300

ctgatcatct gaagtggaat agtttcgtcc caaaacctac ctccttccct gctgccctga    45360

aaaaattgtc ttccatgaaa ccagtccttg gttccaagaa ggttggggac tgctggattg    45420

ccaggtgtta tcactaagag agcaaatagg taaaatgtct ggtaatatac actggaatat    45480

tatgcagtag ttagaagtgc agattagatg tatttacaac aacatgaatg ctaagtactt    45540

taaatcatag tgcttagtaa ataaaaacaa acaatgagaa aatgtatgta aattagagat    45600

tcatgtgtac aatattcaat tttcaagaaa acagaaagat gttcataaac acattataat    45660

ggttgctaag catgggaatg aaaaacaggt agagtggcag agaatgggat atgggggcaa    45720

tggagaaaaa atattaataa aaggaggctt tgcatggcca atgataacaa ttggccacaa    45780

actgggaatt taacctggaa cttgaggtta aaaaaatctg tagaatgcag gaactttggt    45840

tgatattatc cacaatacaa gtaagttatg atttaacctt tagaaggaaa ataagctttg    45900

tgcatccttt aaaattttta attagaatag tttgaagact agacaagtac aggaatagaa    45960

aatctagaga gtttatgaag ctatatattt caaattccat cgaaggacaa agccaaagat    46020

gatttttttt cttgtttgga aaagttgaga gtaagtaagg acaatcagac ttgatgacaa    46080

agccaaaaat gaaggagaca gctcctggat catagcaaac tgttaacaca agagggagga    46140

attgtaggag atacctgtca tagtacagac cagcaaattt ctactcatct tccttccctg    46200

accaaaatct ttcttcctaa gtccaagtta ggtgcctttt ctgtgtgttc tcattgctct    46260

catatagtag gtgtgttgta attgtttacc tgctggtttt ccccaacaga ctgtaagccc    46320

tagaggacaa ggatcaaggc cacctagtta gtattgtgtc ccaggcacct ggcaccttaa    46380

aaatatttgt tgctcttacc tccaaacaac aacaacaacc cccccccaac aataacaaac    46440

aacaaaaatg ggtaacaact agagatggta gatatgttaa tttcctttac tatggtaacc    46500

ttttttttac tatctacatg tatccaatag catcatgttg tataccttaa atatacacaa    46560

taaagtgtat tttaaaatat ctgttgaaga gtaagtaaaa tgaaatgaac ctattaaagg    46620

aatatcagta taatatttca cacatgtgac cattattttc ataacttgct gcgggggtaa    46680

accttaaaat caagactacc ttcattttgt tttggtaatt tgaaaagtaa ggaaccgata    46740

atatttaggc atttttttac tttaatcttt tgtagtttaa taaagaaaaa tttccaaact    46800

acattctgtt aattgtgcta gcaagttatt atgatggcat tttaaaaaat taatgcaaat    46860

aataatgatg cagataatca atttaattga tggctggtca cttaagatcg ctttctaatt    46920

ttcagttatt aaaaggtctt tcaaaataag gctacttttg taaaaaaata atttttatac    46980

tatattgtac attaagggaa ttcatggatg gtgttttcta cacaacagag aaaaaatttt    47040

atgtaaacct gagagcaatt actttaccaa ttaaatcact caaatgttgt agactaaaat    47100

aattgaaagt caaaataaga ttaaagaaaa tcagttttca tatacaaata atggtaaggg    47160

attcaagaaa ataaaaattg gacttaatgc attttaacct atatagtttt gaaaaccata    47220

aaacataaac cttattgctt tgtgtagtca tttttcacct ttgtagagtc catttttcct    47280

tacatgtaaa caggcgccta ttctaatatt cttcatttct tgctgtgttt ccattctttt    47340

tgtctaagat cttttccttc tgcctaaagt acttccttta gtgtatattt tagtacaatg    47400

attaattctc tcaacttgag ttttcagaaa aagaagtttt taaaaacatt ttacgttcat    47460

ctttttaact tttcattaag tataacatac ttaaataaaa atgcatatat catgttctcg    47520

cttataagtg agacacatag aggggaaaaa cacacactgg aacctttcaa atacagtaga    47580

gggtgggagg aggcagaaga tcaggaaaaa taaccaatga gtactaggtc taatacctgg    47640

gtgatgaaat aagctgtaaa acaaaccccc atgacacaag tttacctatg taacaaacct    47700

ggacttgtac tcctgaactt aaaataaaag ttaaaaaaaa aatgcatata tcctaaaaat    47760

atagtttgat gaattcttca caaacgaaac aaaccatgta accaatactg ggatgaaaac    47820

acagaattcc ttcactctag aataatattt tcactctctc taatgttcca gagtgtcagg    47880

gactacaaag gctacaaaac caaatgacag gtctgctttg ttccaagcaa tgttacaggc    47940

taaagataca ctgcttgtag gatttcatac tcttaaaagt tcccaggtac ataaaattct    48000

actaattagt taaatgaagc tgtgtattca tggacaatag ttaaattgtg acacagatga    48060

gtgtacctag caccttgtta gagaaagctc cttagtatca atgagatgtg aaggacatct    48120

aagagttatc agggctagag gtctggggag agttatcctg gctcatgcta gtcttttagt    48180

gaaatggcct ggacaaattc atagtgaaga tgggcagtca attgataaga ttatattata    48240

tttgactgtt tatttctaat aagattataa aaagattata aagttaaaag caaattgagg    48300

tgttgtagtg aggaaagagg attgtataga ttcataatgg ctggctcaat tccagtgttt    48360

ttactctact taagtgtata gatttggtta atttttaaaa tttcaggtaa caaataatat    48420

ggtcatcatt gaaatcccta aatataataa attacaacca ttgtttttac tgaatctaga    48480

ctaggggaag agtaagataa aacaagataa gtagaatgtt ggcaatttaa aaaattgtgc    48540

caggctcagt ggttgatgcc tgtaacccca gcactttggg aggccaagga gggcagatca    48600

cttgagccca ggagttcaag acgagcctgg gcaacatggt gagaccttgt ctctacaaaa    48660

aatgctttaa aaaattagcc cagcatggtg gcacgcacct gtggtcccag ctacttggga    48720

aggtgggagg tcgcttgagt gcacgaggat gatgctccag tgagccgtga tcacagtatt    48780

gcactgcaac ctgggcaaca gagtgagtga gaccttgtgt ttataagaaa atttatacct    48840

ttcaaaaatt taaactcata ctttctgccc atattacagc tgcctccttc tgtggtataa    48900

acgcaatatt aaatattgtg tttattttta tcaaaataag acagaaattc tcaagacaga    48960

aaatgaaaag ttttgtcaag gggtttcaca gacctttcat tgaattttaa ttgcaatgct    49020

aaacaatatt tgaagataac ccatagtggt cccagtcttc agcctgaagt caagaacctt    49080

tagttatctg aatgttctca agctccaaga ctccctagga tgttatttaa gcaaagtgca    49140

ggatttccaa acactagtga ttaatatatg acatctgctt actacagcac tgttgtgcag    49200

ccacaaaatc tttcagaaaa gttcacaata actatggctt actttgataa agaatagtca    49260

gtaggatggt tagtctaata tgctctcata aaaaaagaaa agtattatga ggtggtgcca    49320

ggaccttggg tcctatttgg ctatttctcc aaggatctct caatggtaag atcatcatat    49380

atctaagctt gcctagaaca gtccaaggtc attcctgctg tcttggtatt ttctgtgttg    49440

tgtagcattt attcttgaca caaaatcctg gcttggaaca taaatgctgt agacatcctg    49500

ccaaggattg aatcaaattt ataagtgtaa ccctgacagc tagggtagag ctgtctattt    49560

ccttcctcca aagatgttat caggtattta gattagtaaa atgagaaata ctgagatacc    49620

cttataattc aaggagcaca taggaatgga tatagacttg gtttaagtat tatttttccc    49680

ctgtattctc cagattcaat cgtttcgcac ctttgacttt cttatctaaa ctgtagagct    49740

attcaatgac taaattgtac ttcttattgt ctttgaatgt ttcagcttta tcttgttatt    49800

gacatataga atttttatta tcttgatatt tcacttattc aatcggaggc caggtgtagg    49860

aaggactcca atattttctt ggtgccaaga catagaacag agttttcaga tccatctgga    49920

aatttttctg ttttcatggg agaaggccta taagagttca tactggaagg aaacattgcc    49980

tctctcatct ctcctgatga catatttctc ttttatcatg ggaagtctta tgttatgagt    50040

agataagtta tgaaggtgat gttatcgaac ataggagagt aatttaaaat attattgaca    50100

aaaggggctt ttgtagttat aaaccagggt taagcgtatc cttgtcagcc agagtggagc    50160

tgtatttttg tcttgctctg atgatgttat caggtgttca gagctcagta aaatgagaat    50220

ctcagagtca aatacatttc ttttatctct atgttacctc acagttccta aagtaacaca    50280

gaaatcaaaa gtcagccttt tgtaccttaa cggcatcatt aagatggata tgtaataaag    50340

cttcaattta acaacttaaa agatatttag tatgcttacc atggttgagg gagttaaatt    50400

gtacttattc taaaagaaaa tacacacaga ttccctcata agtgtatttt tttagcctat    50460

tataataaga cataatgact ctcaagtata attaggactc agacattgtg actccagttt    50520

agttctatgt ttataagtca taagctcatt cctgacccag gagagtgcat ttatagaaaa    50580

ttatcctccc aggcatgatt actttaagaa aactgatcag catttctaat ggatctccta    50640

ttgatcaaag caatgctatt ttgtactgtg taaaatatgt atttttaatg tattaattgt    50700

aattcatttt aattaaaagt ggttcaaatt tatgtctatt atcacttagg tatattatag    50760

ataatataga taatggcaat gcatttacct gataaattca aattcactga gctattatta    50820

cctttattta atattagaat aattctacat ctgtgatttc cttttgctta aacttttgtc    50880

ttggaataga tttatggaaa aatggtgcag atagtaagga cagtttcaat ataccccaca    50940

tccagtttcc cctgttatta acagtttata ttagtatggc gcatttgtca caattaacaa    51000

aaccatgtga tacatcatta ttattaacaa atgcccttac cctattcaga gttccttagt    51060

ttttcactaa tttccttttt ctctttcaag atctcaccca ggctaccaca ttacatttaa    51120

ccatcatacc atcatatcac cttaagcatc tctaggctgt cgcaatttct caggctttcc    51180

ttgtttttga tgatgttgat actttgagtg agtataggtt aggtattttg tagaatgttc    51240

ctgaattggt atttgtctga tatttttctc atggttagat taaggctata agttttggga    51300

aggaagatca catatgtaaa aggccattct catcacatag tatcaatggt acacattgtc    51360

aatgagttat cgttgttgat gttaactatg atttaaataa actttttagg ttctcatgtt    51420

ctgattctat ggtgccttga gaatgcttta aaaattaatg gtacttcagt caagatttta    51480

cctgcaggaa aaaatcacta tgtgtttcta gagaagtgac attttcaaag cagtatttca    51540

ttttacaaca gttagcatca ataaaaatgt attttttatt tatctttaca tttgtccact    51600

gtcttaaata tttatactga ctcaatctca ttcagatttt ggcagatctt ccaaatgatt    51660

aattggacca attttaaata aataaattta tttatttatt tgagatggag tcccgctctc    51720

tggttcaggc tggagtgcag tggcgcgatc tcggctcact gcaacctctg cctgctgggt    51780

tcaagtaatt ctcctgcctc agcctcctga gtagctgaga ttgcaggcgc ccacaccaca    51840

cctggctaat tgttgtaatt ttatcgaaat aagattaagt tatttacagg taagaggctc    51900

agtgatggaa tgcaaaacag cctgaaatta ttatagagtt gtgagcatgt agctattttc    51960

ctgctccttg aaataagaaa atatagagtt gtgagcgtgt agctattttc ctgctccttg    52020

aaataagaaa atgtcatatc atagtccctc taatcaagat taaagaaaca aacaagtaaa    52080

cactacttgc tttctacaag agatgtcaaa agttatcaaa ggaaacatac tgtttaaagg    52140

aattatctgg gagatatttt taagagaata acttattctc ttaaataaat atagctttca    52200

tatataagat aaacattaat tattacaaaa gcacaacata ttacaaaatt atatggacat    52260

aatatgcaca tactctaact gagccacaat agaattggtg ccctgacact aataaatcat    52320

ttgggaactg cagtttggag tatttagtac ctgttatgtg gccaagaagg taatagaggc    52380

cactgagacc ttttccagtc taatataatg ggcacaactc acattttttc cttttagtta    52440

ttaggtaaaa attagtgttg gtgtttactt cagtgatttt ttagaggatt tacaattttt    52500

actgtgaaca cttagggaaa cccacttccc acctcatcct atagattttc cctatgtgaa    52560

gggttttcat agtaccttgg ggatgaaagg aagtccccca aataattttc ctgatgtctg    52620

cttccaatat ttgacttcaa gaataccgtt ttccaaatag tatgttcaga gccataccag    52680

gcacacagag tctctaaaac tctggagaga ctgtaatatt tctttgcttg aaggaaggga    52740

tcattcttgt attctgttca gagattacat taatgatatt taaatgtttc tcagaagata    52800

aaccaagtgt tggaatttat ttgcttttga ccctgttcag caatattcaa tgaataaaaa    52860

agaaaaaagt cttaatgata gttcttgagc cacatgactt tgtctaatta aaaaatattt    52920

tgcaagtctt catataaagt tcaaaacaac aaaggtgaaa tgatgggaat tttcttaaga    52980

aaggaaattc tgcagtgacc caatcctttg agcaatcaac agtcattcta gggatactct    53040

tgtattgttt aaaattacat tttacaaaat aaataatgtc ctaaatgcct caacattttt    53100

agaatcagaa aagttgctta actgggatgt ccaagatcat ttagctagta agtagtgaat    53160

ccagtattca aaacccaggc tttctagctc ctgaacttgt cctagactca ctactctaaa    53220

ctaaatctct gtttaatatt acatgctcat atgaaatgtt tcatgtttaa aaggccaata    53280

cattcccata aatggaaata tcctcattta atataattaa tatattttaa ttatggaagc    53340

atgataaaat tatccaaagc aaggaattaa aatagaagga tgagacaagt taataatctt    53400

atgagctcca tgaatacgtg ttcattatgt gcaaaactct tcctgttaag cactttatat    53460

acagttaacc atcacaatct aaaccactct tcggagcatg attattaact caatttttca    53520

aactaggaat cttaggctca gagaggttat gtcatctcca cagggtcaac agctctaaaa    53580

tgtggagcac aaattgtaat gggaaaggcc aagatgatta ttgacctgtg agccactgaa    53640

accagtgtga attgttctgt atggaataga agtacacttc atgatatata ttgtaactgt    53700

tgctgaagga ttttattcat tttacattgg atcaaatgga aatcgagctg tatattaaag    53760

attttacaaa agctccaaat taagaagaaa ctatagaaac tcaaataaaa tgaaattttt    53820

tttaaaaaag tgttttctaa gtagtgtttc ataaagtaat acaaattttt agttattagg    53880

ctgataaaat aaatctattt cttttagtat ctttgtcctt tctttttgaa tgttgttaca    53940

cattcctgaa agttggaaga tcagcgtttt aaaataaatg ctaggaaaga cctaatgtaa    54000

ctcttgatta ttttacagca tcaagagttc ttccttcttc ttgcttattg cttgacaaca    54060

gattgactga ggatgcttta gagctgacag gtttggagga tgagggatga gtgagtatga    54120

gcaaaactct gaggaggagc actgcatgcc tcaaaagaac ttggagagaa taagagttac    54180

caaaaaaaaa aaaaaaaaaa gattttgcca ggctataatt ggaatgaagt gatataagtg    54240

acatgaatga tgcttaaaat gttgagaatt aaaaagtaaa tattaaaaca ttgaaaaact    54300

tttttttacc ctttttggtt tatcatcttc cttctctcct tcaacttcca tttttttcat    54360

tcagtttttc ccctcattcc aactcttctt tctttaattg aacataatag agactcggag    54420

ttcaaaatat gtgttgtttc tattgaattg atagattttt tttttttttt tgagacaggg    54480

tctctgtctg tcatccaagc tggaccgcag tggtgtgatc atggctcact gcagactcaa    54540

cctccccagg ctcaggtgat cctcccacct tagctactct caagcagctg agactacagg    54600

tgcacagctc catgcctggc taatttttgt acttttccta gagacagggt gtcactgtgt    54660

tgcccatgct gttcttgaac tcctgccctc aagtgattca cccgccttgg cctccgaaaa    54720

tgttggaatt acaggcacga gccactgtgc ctggtctatt gaatggaatt tatgtttatc    54780

ctttccaatt ttaaaatagt taactttaaa gttgtgtatt ttacattcat tgtcttcaaa    54840

ccaaacaaaa tccaaaaact tttctacttt ttgaattgaa ttttttctct ccttttgaat    54900

aataaaacct ggtcattgat gtatgtgtac tcatctgata tttttgattt aacaaaatca    54960

aatggagggt tcacgttagt attttatgct ttttaaaagt agacatgctt atgctcttcc    55020

ctaaaacttt tatttcagca ttacttagat aagccctggc atctgtattt ttttaggtta    55080

cacagatgat ttttttgtat accctggtca atagccacag tggagtatac ctgcattctg    55140

atatatacac tcttgacaac catagagaca aatgatactt agctgcattt ttaacattac    55200

ctaacataag tgaaagggat tttaaaacag tagtattttg gaaaacagca gataataaaa    55260

cattaatttt gtgttgtggg ttattggtat taagtatcat gtaatgccca catctcaaag    55320

ctcactatgg aagaattggt gtcagataat aggaagattg atattgttga aaaccatgca    55380

ttcagcaagc cagccattgg tagcacccaa tgaagtgttc agtattcatc taagcagaga    55440

aagtagaaga cacaatcttt actgtaactt tgagtgtttg cagtgtgtca gatggtccct    55500

tgaagaagaa atattaataa aaatgaattg caaattgtct ccaatttacc tgaaagagat    55560

caaaataatg tatctaaata tatggtgttt gaaaggtgta gagtcagtcc atatttttca    55620

agcccagtga aggtaacaga acagtttcta cttaagcagc tgtttgttgg tttctttggc    55680

tcaagagaga ggtataatat cttcttttat tttacagctt tttaatcata ataataacta    55740

ttataaaatt aacaaatgca catggtaact aattcaaaca atttttgctt tatcccttta    55800

aagccattat ctagggaata atcacttccc gcttttttaa aaaaaagttt ttctgatatt    55860

ttccttttta tctctaaata atatgcttat gtctcatttt tatttcatca acttatgtaa    55920

tgttttctaa ctttctaatt tgaaaatgag gaatttattt tatttatgta aacttttctc    55980

tttctgcccc attctcaaat tccaagcagt tatgttttca tttctaagta attctatggg    56040

ttggatttat acctttaaat ggaatatacc tgaacctcta tttcttgtta cttaaacttt    56100

agccaggatg cactaactgc cttcaatgta agataagggg tcagctctcc aacttttccc    56160

tcaccactaa tccccctcta cctctcaatt tttgtaagct attccattac ttttacactg    56220

ataatattta acacatatat gtgtatatct tgtctttgtg taaataaagt tctataattg    56280

tacttacatt ttatatatgc tttggtaatt ggcacatttg tgagatgatt aactgataca    56340

atttaacaat attataatta tgtatgtatt tttcatttta aaacaagtaa catggtttga    56400

tctagaggag gaatttaaac ctctcattca aactctgcta cttgaagaac acatcaaact    56460

caagtggatc ctctctgctt caattctacc agttgttcaa gttcatgcct cattttgaat    56520

tgattcctat ttggacaata tggctattta cacgttctaa agaaacaaat tccctttgct    56580

tttattcaca ctatttgtga aacatcttgt attctatgtg ttttagaagt actttttttt    56640

ttttgctcta ccttaatcca aagtaactta aaaaaaaaag ataaaaagga gttaaatttt    56700

gaattttctt atacctagaa atatattttg tttgccatca cacttgataa taggttgtct    56760

gataatagaa tttgattcaa aatattttct ctcatcacac tgaaagcatt gattgtgttc    56820

tagtgtcaat tatggctaag gaaattttaa tggcaatcta attttcattc tttttagtta    56880

gttatcttat ttttggaaga ttataaaatc ttgtttctat tgttaatgct ctaaactttc    56940

acaagaatgg aacttttaaa ttgatcttct tttgtacttt tagcttgatg actcttggtg    57000

aattttctgc cattactttg tttattattt cctatctact atttgctgct ctcttgagac    57060

taatgtcgaa caacatggat tattctgtat cttctaagtt ttattttgta cttttttaat    57120

ttttaaaatt ctcctaaaat atatagaaaa atctaagata tagaactcca tgcattttta    57180

catatacata ttttcccatg taaccatcac atagatcaag gtatagaacg tttctagcac    57240

ctgagaatgc tcactggtgc cccattctgg taaagtgccc cttttgggta aagtaaaagg    57300

taactacaat tatgacttct ccttttcagc aagcattcta ctgaaatttt ttgtttcaca    57360

aagcatgacc tttacccaga attgatgttg ttgtttttgg tagcctattt ttttttttta    57420

ataaaagata ctctgtctcc tcaaatttct ctaggaatac taactttaac ttctcaatat    57480

cccacaatgt ttgctttttt ttttctaaag ttaaaagttt ggtctgttca tcttagtctt    57540

tcaattttat gtttggtaga tcttcattac caatttattc ttgataatct attaatattt    57600

atggaagaaa ggccaggttg gtgttggcca ggtttgcatc tgtctttata caggtctgtt    57660

tcccagacaa atcctctctt gaaagagagg gatgactgaa aggtctgtgt atatacatgt    57720

atggtgtact gacaggcagg ctacatttta ggatgtatgg atgaggagta gataagggag    57780

tcacctttcc ctcgactcca ccctggttct agctaaaatg gacatggata ccctaggagt    57840

cctaccttaa ttaatgcaga tattatcctt ttggtgatag cttggagata aaccactctg    57900

ctacatattt aacatagaga gggaagtggg acaatgtttt ctgcaacatt attgaataaa    57960

taatccatgg attaatcaac ttgttttctg atctacatca catatttgcc atagaaatct    58020

gtgacttctc tgctagaaag aaattctaac attctcagat gagtgttcta gactgtagct    58080

tctgctttga tctcctcact agggtaatct tatgatttat gataactttt tttgtcttcc    58140

tctggttttt agtgatatta tctaacattt cgccactgta catctttgtt tttactgcaa    58200

tggaaatttg aaggccagag agtgtgataa acacatggga taagaccatt ttcatgaact    58260

gggagctgac attgctttga ctggaaagat gtgtgaagaa aaatagatgc tagatagaca    58320

aatacatgat atgatatttg gacagacata gatccataga tggataagca tagataaaac    58380

atatctatat atatgtgtgt gtctgcatac atagaaaata agaaagagtt cagaataaat    58440

atttccatat tgattttaac tataggaaat cttagataca agaataacac attcattttt    58500

taattttagt agttgcctaa gtattctcta atatgagatt aatggtgagt gggtaagata    58560

gtaatgagaa aacaaaagta ctgcctttat atgcaacatt gggatttcat tctaaagaag    58620

atacaatcat agtaatgtta ataaaagtgg aaatgtagca atatattttt caaaattgta    58680

aattaaacat gacaagaata aatattgatt gatttcattg actatataaa attaggtcaa    58740

ataattttaa atgatttttt tcaaagtata ttttctttct tctggataga aaaacatgac    58800

attttcgttg tacaaatttg aaaagtaaag tataaagaca taaaaataat ccataatctc    58860

ttaactaggg ctaaactttg ttaaatgcat tgtgtattta aattaaatat cattttaaaa    58920

attattatta atttacatct atctgtgtgt ataacctgga ttccacttat tatgcattat    58980

atttttataa ttcatttaat tcattaaata gtctttgaac gctctctttc aaagctgctc    59040

attatttcat tatacattca ttacttcatt tagtgtaacc cttactgtta ggattttgga    59100

ttgattataa tttttcaata ttataaaaat attgtagtaa atatatttat acatgttaga    59160

ggacacctga gattactgtc tttgaataaa ttcctagaag gaaaattatt tggcaatata    59220

aacgaattca cgtgtttaag gcttttgata gatattacaa aattaccctc aaaaagtttg    59280

tacactttat ttatttattt gagacggagt ctcgctctat tgcccaggct ggagtgcagt    59340

ggcacgatct tggctcactg caagctccgc ctcctgggtt cacgccattc tctgcctcag    59400

cctcccgagc agctgggact ataggcgcct gccaacatgc ctggctaatt tttttgtact    59460

tttagtagag acagggtttc acagtgttcg ccaggttggt ctcgatctcc tgacctcatg    59520

atctgcctgc ctgggcctcc caaagttctg ggattatagg cgtgagccac cgcacccaga    59580

cagtacacat tatttattac tttcatccag acaggcaaca ctgatttccc ctataacctc    59640

tctaatatca ctattacttt tgttaaaatc tttgctaatg attaataggc caaatttggt    59700

tccccatgtt tattttaata tttgtttctt tgattactag tgaggtttga catggttaca    59760

agtgtttatt aaccatttgt atttttagat aattatgttt tttactaaat tttatgagat    59820

atattaatat ctttattcat taaaggaaaa gcacttcatc tgtcatttgt attgtacttt    59880

ttttattttg tggatgcctt ccacttttaa aaaccttcat tgttatgaga ttaaatctag    59940

cattctttat ctttttcgat tttgcctttg gtgtaatgct ttacaagtcc tctctactct    60000

cacattaaat aagtattcat tttcactttt attagaatgt ttgagcttta tttttccatt    60060

taaatattta ctccaccaga aatctcaaat cttaaactaa atgcctgact aatgaaaact    60120

cctgtggcct gtttatccag aagactaagg gaagaggaaa gaagttgtag tcacacatag    60180

gtcctgcccc atcattgcat cttctttgtg tgtgttggtg aagtgtgagg ctccattttt    60240

acttatgttg ccctctgtaa ccctgtcagc ctatcatctt gccaccccac tggcctggta    60300

caataacttc caagcaaact cagatgccaa ctaaagctgc tcttcttcaa agctataaaa    60360

ttagtaaaat gaaaggaagt ttcacctctc caaactagag gatgatgatg aaatctgatc    60420

aaggtctctt caacttccat ttcacagatc atgatgttaa gcaggtgctt agtgtcttcc    60480

tttaatttag cttgatcagg gaaatattgc ccatgcatgg taccactagc attgaccacc    60540

ctttgcctct gcttttttca tatactttag tcattctgga gctgtgttga gcatgtgcat    60600

gggggttggg ggagacagag acagaggaga ataggaatat tggaagaatc aaactggtaa    60660

tggacatctg agttcacaac atctttgtac ctagatttct gtcaaataat tcttgaaaga    60720

gatggtaccc tccagttgaa tgtagaatct acaaaaacac cagttattca agccaacttt    60780

tcttcaagag ccacagtatg tctacactga aagtctagtg aggcaagtta tcccgtcttc    60840

tcacctttat gatttccaaa agtgttgagg aatctccaaa gcacaagtgg caactgcttt    60900

gatttgattc attgatttgt ttccttttta ctaaatctct tcctattctg aggacaattt    60960

tcacatattt taggattcaa aattcttaat gcatattcat agtagtttta ttaagatata    61020

atttacacac cataaaaaat caccatttta aagtgtatca ctcagtggtt tttagtatgt    61080

tcacaaaggt atgcaacaat catcattatg tagttttaga atatttttat caccccaaaa    61140

gaagccccat actctttaac cattaaccac ataaccatca ataatcactt cctattacac    61200

ccagcctctg acaaaaaata ctctacattt tgtttctggg gatttgccta ttctggacat    61260

ttcataagat ggaatcatat cgtatgtggc cttttggctc tgtgttcttt cacggggttt    61320

tcatcacatc catgttgtaa catgtaccta tacttcattt gtttttattg ctaaatacta    61380

attcagtgtt tgaatatccc acattccttt atccatttat tcattggtga gtaatgaggt    61440

tgtgtttact ttttggctag tatgaataat gctgctgaac attcatgtaa acgttcttgt    61500

gtggacatat gttttaaatt cccttgagtc tgtaccaagt agtggaattg ccgagtcata    61560

acttactctt tacctttcag aatcatccta cttttgaatg tgtatatgaa atatccctta    61620

tttttcacta cattctttaa aaacctttat cctaactttg gtttccatca aaatacaggc    61680

atacttcatt ttatggggct ttactttatt gcacttcaag atactgcatt ctttacaagt    61740

tgaaggtttg tggcaaccct gcattaagca agtctgtcag cgtaattttt tcaacagcat    61800

gtgctcactt catgcatctg tgtcacactt tggcaattct cacaatattt caactttgta    61860

attgccatta tttaattatt actgtatgtg ttatggtgat ctatgatcag tgatctttgt    61920

tgttactgtg gtaattgttt tggggtgcta tgaaccacat ccacataaga cagcaaacaa    61980

tcattaaatg tgacgtgttc tgtttcagca tccctatctc tctccctttc ctcaggcttc    62040

cctgttccct gacacacaac gatgttaaaa ttaggccaat tagtaaccca ttcccacccc    62100

taatgttcaa gtaaaggaag aattgcgcat ttctcacttt aaatcagaag ctagaaatga    62160

ttaagcttag tgaggaaggc atgttgaaag ccaagatagg ccaaaatcta ggcctcttgc    62220

actaagtact tagccaagtt gtgaatgcaa aggaaacatt cttgaaggaa atcaaatgtg    62280

ctactccagt gaacacatga atgataagaa aacaaaacag ccttattgca aatatagaga    62340

aagttttagt gatctagata gaagatcaac cagccacaac atttccttaa gccaaagcct    62400

aatccacagc aaggccataa ctccaattgt atgaaggctg agaggtgaag aagctggaaa    62460

aaaaaggttt gaagctggca gacggtaccc catgagattg aaggaaagaa gtcactgcca    62520

taacataaaa atgcaaggtg aaacagcaag tgccaatgga gaagatgcag caagttattc    62580

agaagatcta gctaagatca ttgataagag tggttacatt aaacaacaga tttgcaatga    62640

aggtctaaca gccttctact agaagaatat attatagcta gaaaggagaa gtcaatgtct    62700

ggcttcaaag cttcaacgaa caggctgact ctcttgttag gggataatgc agctggtgac    62760

tttaaattga agcaaatgct aatttatcgt tcagaaaatc ttagaattat attatttaat    62820

tattcagaat attaataatt atttactatt cagaaaatta cataataatt atattattta    62880

ctattcagaa aattacataa taattatatt atttactatt cagaaaatta aataattata    62940

ttctttacta ttcagaaaat taaataataa ctatattatt taattattca gaaaattaaa    63000

taataattat attatttaat cattcagaaa atctcttaag aattatacta aatctactct    63060

gcctgtgctc tataaataga acaacaaagc ctggatgaca gcacgtctgt ttacagcatg    63120

gttcactaaa tattttaggc ccagtgttga tacttatagc tcaggaaaaa aaaaaaagat    63180

ttctttcaaa atatcactgc ctattgacaa tgtgcctggt cactcaagag ctctaacgga    63240

gaggtacaag ggcattaatg ttattttcat gcctgctaac gctatccatt ctgtagccta    63300

tgggccaaag agtaatttca acttttaagt cttatttttt aataaataca ttttataaga    63360

ctatagctgc catagatagt gattcctctg atgggtctgg gaaaagtaaa ttgaaaatct    63420

tctggaaagg attcaccatt ctagatgtta ttagaacatt aatgatttgt gggaggaggg    63480

caatatacaa acattaatag gaaattggaa tgagttgatt ccaactctca tggatgacta    63540

tgagaggttt aagacttcag tgatggaaag aactgcagat gtggtggaaa tagcaagaga    63600

attagaatta agagatggag cctaaaattg tgactgaatt gctgccatct cgcggtaact    63660

tgaatggatg aggagttgct tctgattgat aagcaaagaa agtggtttcg tgagatggaa    63720

tcttctcctg gtcaagatgt tatgaacatt gttgaagtga cagcagagga tttagaatat    63780

tacataagtt tagttggtaa aacagcatca ggctggagag tggtgctacc aaaggcatta    63840

tcataaagac ttttaaaaga ggaaagttga gttgaattgc accaaaggta aatatagacg    63900

aaaagaaggg gaatttagga aaatttactc agaaaattgt cattttttac tttaaagcta    63960

tgaagcgtaa acttcaaatt tctgagtata aagatggtta gaaggcacga aagataagtc    64020

ccgcccattg cctgacacat agtaatccct taacaagctg ataattctag aacatgttac    64080

cttttgtagt tgaaactaaa aatctgttta tgttgttatt attagttttt aatgggcctt    64140

tcttggcagg caaatagtta agtctttatt tctttgtttc catccaggcc tcttatgtga    64200

ggagctgaag aggaattaaa atatacagga tgaaaagatg gcaatgttgc ctcccccagg    64260

acctcagagc tttgtccatt tcacaaaaca gtctcttgcc ctcattgaac aacgcattgc    64320

tgaaagaaaa tcaaaggaac ccaaagaaga aaagaaagat gatgatgaag aagccccaaa    64380

gccaagcagt gacttggaag ctggcaaaca gctgcccttc atctatgggg acattcctcc    64440

cggcatggtg tcagagcccc tggaggactt ggacccctac tatgcagaca aaaaggtgag    64500

tttattttga cttcagtggt cagtttctgt tggcttcctt ctgtataaaa attattttaa    64560

attgagatta gtgaaattta gtgaataacc atatcatgac cagaatgtta aattaaatat    64620

atatatatat atatatatat atatatatat atatatatat ataggatatt cagaatctgt    64680

actttttcaa atttttcatt gaaattggct ctggcattgg catactactt ttaatttttt    64740

tttttaatta tactttaagt tttagggtac atgtgcacat tgtgcaggtt agttacatat    64800

gtatacatgt gccatgctgg tgcgctgcac ccactaactg gtcatctagc attaggtata    64860

tctcccaatg ctatccctcc cccctccccc caccccacca cagtccctag agtgtgatat    64920

tccccttcct gtgtccatgt gatttcattg ttcaattccc acctatgagt gagaatatgc    64980

ggtgtttggt tttttattct tgtgatagtt tactgagaat gatgatttcc aattgcatcc    65040

atgtccctac aaaggacgtg aactcatcat tttttatggc tgcatagtat tccatggtgt    65100

atatgagcca cattttctta atccagtcta tcattgttgg acatttgggt tggttccaag    65160

tgtttgctat tgtgaataat gccacaataa acatatgtgt gcatgtgtct ttatagcagc    65220

atgatttata gtcctttggg tatataccca gtaatgggat ggctgggtca aatggtattt    65280

ctagttctag atccctgagg aatcgccaca ctgacttcca caatggttga actagtttac    65340

caccaacagt gtaaaagtgt tcctatttct ccacatcctc tccagcacct gttgtttcct    65400

gactttttaa tgattgccat tctaactggt gtgagatggt atctcattgt ggttttgatt    65460

tgcatttctc tgatggccag tgatgatgag cattttttca tgtgtttttt ggctgcataa    65520

atgtcttctt ttgagaagtg tctgttcatg tcctttgccc actttttgat ggggttgttt    65580

gtttttttct tgtaaatttg tttgagttca ttgtagattc tggatattag ccttttgtca    65640

gatgagtagg ttgcgaaaat tgtctcccat tttgtaggtt gcatgttcac tctgatggta    65700

gtttattttg ctgtgcagaa gctctttagt ttaattagat cccatttgtc aattttgtct    65760

tttgttgcca ttgcttttgg tgttttagac atgaagtcct tgcccatgcc tatgtcctga    65820

atggtaatgc ctgggttttc ttctagggtt tttatggttt taggtctaat gtttaagtct    65880

ttaatccatc ttgaattgat ttttgtataa ggtgtaagga agggatccag tttcagcttt    65940

ctacatatgg ctagccagtt ttcccagcac catttgttaa atagggaatc ctttccccat    66000

tgcttgtttt tctcaggttt gtcaaagatc agatagttgt agatatgtgg cgttatttct    66060

gagggctctg ttctgttcca ttgatctata tctctgtttt ggtaccagta ccatgctgtt    66120

tgggttactg tagccttgta gtgtagtttg aagtcaggta gcgtgatgcc tccagctttg    66180

ttcttttggc ttaggattga cttggcgatg cgggctcttt tttggttcca tatgaacttt    66240

aaagtagttt tttccagttc tgtgaagaaa gtcattggta gcttgatggg gatggcattg    66300

aatctgtaaa ttaccttggg cagtatggcc attttcacga tattgattct tcctacacat    66360

gagcatggaa tgttcttcca tttgtttgta tcctctttta tttccttgag cagtggtttg    66420

tagttctcct cgaagaggtc cttcacatcc cttgtaagtt ggattcctag gtattttatt    66480

ctctttgaag caattgtgaa atttagtata atgtttagta taacatagta tacattgttt    66540

agtataattg tttagcataa catttttgga catgacacag tgatctgcca aattttataa    66600

tcatacctat tttttcctgc taataattaa ctctcatgtg tatgcagacc caaaaatcac    66660

ttaaaagttt ttaatgagaa tgaaaattgc taatttcaat tttaaaatac caacaattct    66720

ttttattaaa atttcaagta taaggtaact tgatcttgcc aatactatgt agtatgttgt    66780

gatttttcat gttagctcag atgacctccg gtttataaag tctccctgat aattttgaca    66840

gtcatgtgac cctgttccct cttcactctc attcttcccc ctttatattt ttctgtatga    66900

tatctgtcac atcttgcctt atattagtta ctttcttctt ttcatttttc taggaagttc    66960

cttgaataca aaactcatgc cttatttttg ttcaaactcc ttttcattac ctgttatgat    67020

atagtttctg actatacatg tattagtctt tttttttttt ttttttttga gacagagtct    67080

ccctctgttg cccaggctgg agtgccgtgg cgcgattttg gctcactgca agctccgcct    67140

cccgggttca cgccattctc ccacctcagc ctccagggta gctgggacta caggtacccg    67200

ccaccacacc tggctaattt tgtttttgta tttttagtag agacggggat tcaccgtgtt    67260

agccaggatg gtctcgatct cctgacgttg tgttctgccc accttggcct cccaaagtgc    67320

tgggaacaca ggcgtgagcc accacgcccg gccgtattag tccattttta cactgctata    67380

aagaactacc tgagactggg taatttataa agaaaagaga tttaatttac tcactgttct    67440

gaatggcagg ggaggcctca gaaaacttac aatcatggtc gaaggcaaag gggaagcaag    67500

gcacatctta acatggtgca ggagagggag aaagaggagg gaaatgccgc acttttaaac    67560

ccatcagatc tcatgagaac tcactcactc actatcatga gaacagcact ggggaaaccg    67620

ctcccatgat ccaatcactt accaccaggt ccctcccctg agacgtgggg attacaattc    67680

aaaatgagat ttgggcgggg acacagagcc aaaccatgtc aatacaattg cagaaagaat    67740

ggatgaataa ttttttaaaa atacagtcta ctgagattta agacaaaaag gattgtactt    67800

gaggactagg tattaatttt aaaataattt tccatgtaaa agtgaatttt acattaaatt    67860

gtatttagat agaactgata cagtgaaagg gagcaggaaa ataaaaggac acctgaaaac    67920

aatagactct gatttgtttt cttgagggaa cgctgccgca tacaaataaa aagcctgact    67980

cacagactta cctcctgaat acggtgagaa atgcttattg ccagaaaccc actgataacc    68040

ctatataaaa tttagaaagt cagtgtcttt cagctaacac aagtcatctt cctgccaacc    68100

ggagaaaaat aaggctggga tttgaacttt gtctttctga tttctaagcc aatgctttag    68160

gttgctttaa tattttgttg ttactgctgg ttgtttttat ttcttaactg aatactaaag    68220

ctatggaaaa ggacacttat ggaatggcta caataacatt tcaagaatgt ttgcttctat    68280

tcatatcgtt ttttaaatta ccgtggttag taagtgagga atcctcttaa tttaagtccc    68340

ttttaaaagc taatattagt attataacta aaataaagaa attgaactca gtgattggaa    68400

ggattcttcc aactctgacg ttccttcaac ttaggaaaat attttttgaa ataactcata    68460

ttttggaaca tgtgctgcta accataacaa ttgccagcaa gtattaaaat tctcaaggtt    68520

ttatgataaa aatattagag atagctagtt tctatttggc tttcttaaaa tgcagtgtaa    68580

tggaagggaa agaagttgta ctttaaaata acttaaccac agttattgtt actggtgaaa    68640

gaaaatgaaa aatatgaaat acagtatttt gaaagctcta agcaatacat gctaacaaat    68700

agctcaattt ttaaagttac tatgaagaag tggacttgga gttcattggc caaggtgaca    68760

ttgatagatg cgttgatgac attggaacca cattgctgga gtctgatggc agtgtttctt    68820

caatataaca ctgccatgta gaaaggtaaa ctgctgatat tgatgtgaaa aattgatatt    68880

ttggattctc aatttcatcc tttctttttc ctcctgcaga ctttcatagt attgaacaaa    68940

gggaaaacaa tcttccgttt caatgccaca cctgctttat atatgctttc tcctttcagt    69000

cctctaagaa gaatatctat taagatttta gtacactcat atccttttaa aaatgattac    69060

atccagtggc actttatggt gtaatttttg ctattttatt caaatataga tgttatacct    69120

tttgcacctt gaaagactct ggttttagtt tattaatttc agtattatta atataatttg    69180

tcatgggtct cagagaagac tgggagagtg gcaatattaa gattttagga tatgttactt    69240

ttatttatta ctctcttgtt caaagagaca aaatagtcta caagctcatt tagaattttt    69300

ttcttaggaa aagttgtaag catttcaaca agtgtcatcc tcaaatattt caaattccca    69360

ctgtcgtctc ttttgttcct tgattctaag ctaccttatt cagcatgctc atcatgtgca    69420

ctattctgac aaactgcata tttatgacca tgaataaccc accggactgg accaaaaatg    69480

tcgagtaagt gggtataagt acattttaat atagttttgg tattatcatt tcatcctttc    69540

cttttcctgc caggaagtta ctgcatttat gaagatgggg aatctttacc ttcccatgtt    69600

atatgcttgc ttttcttttg ttctttacct cctctatgat attaacctgc tagattagaa    69660

aaattagatg ctacagtgtt ttctcaaaga atgaacttgt cagatgctcc atcctgttct    69720

tagacatgtt acacatattt tattcttggg tgtatgtttt ataattatat gggtgtattt    69780

ttaaatgatt gggtgaattt ttgatagaag caatgtagga aatttttagg cagatctgag    69840

acctatattc ttagttattt caagtacctc tgctttctgg gagtgtttct gatattgaca    69900

ttttaatatt ttctggatag acctattgta gtttaatagg gtgtgtccat aacccaacag    69960

ccatcctcca atatatgtct tccagtggtt aattagagaa aataagttat aaagatttac    70020

atggtggttg tattcttttc acatctagta tcccaatgga atcttgtgtt taggtacact    70080

tttactggaa tatatacttt tgaatcactt gtaaaaatcc ttgcaagagg cttctgtgta    70140

ggagaattca cttttcttcg tgacccgtgg aactggctgg attttgtcgt cattgttttt    70200

gcgtaagtac tttcagcttt ttgaaacggc aaatttatga aaatctcagg cagcacagtg    70260

ttccaataac agcaaacctc tggggtctga tttttccagc atggaatgtc tgtatttaaa    70320

ggaaaatgga agctatatga aagctagtca ttgataggca aatactaaat ttttcaaaaa    70380

gactatctcc cactcagagg tatgtgacat cattgagatt gatcatcttc ctccatgctc    70440

agcacttgga tggatagtct atgcagtgcc aattaggttt acactttttc caagttcttg    70500

tttaaaaatg aataaaacct ataagaagca cacaaaaaac tcaggccttt aaatacaagt    70560

acagtgctct ttatattacc ctgtattatt caattatttt atatttttgt attaaaatat    70620

aaaagtatat atttgtaaaa gagctgtcac tgcttactaa gcctaagatt aatgcattgt    70680

atacacatta tatatacact cagtttattt tcaaggaaaa tattacatta cagtataatt    70740

ttaatttatt cataattgtt actcttttcc caaatgtatt tatcagaaaa atggattttt    70800

acaatctcat atctagatat tctattttcc gttaatgact ttgaattatc aaagtaatcc    70860

aggttcactg gagccaccta gacaatacag aagggtctta agattcctaa tatccgattc    70920

cttcatccct gcctaacctc ttttccatca ggctccctcc ttttgaggtc acatatgatg    70980

gggcagttcc atctgctacc tgctgctaag aaaacattgt gcaaagaaga ctgcctcttc    71040

tcataggtct cctttttttc ctattggtac aattcaaata ctacaaaatt cacaatttta    71100

aagtatacaa ttcagtgttt ttcagtatat tgacaaactt gcgcaacatc accactacct    71160

aattagagaa gtttaacaac cccaaataga aactctgtac tcattagcag tcacttcaat    71220

ttccttctct ccctggcccc ttggaaacca ctcatctatg ttttatctct atggatttgt    71280

ctatttggat ttttttatga atggaaatat caaacagtat gcagcctttt gtgtctgaca    71340

cttagcatac tattttcaat gttttataaa aaattaaaag tctaaattac cataatgtta    71400

agggtccaac aattgaaaca tttagttgtt tacgcattta agtgtatgaa tccaatttaa    71460

taatatataa tatctgtatt ttgtttgcat caaatgagtc aaatcaatgc taattaaatt    71520

aagttagtta tgatagcaaa aaagacttgc agaactatac atttaaaata gaagccccaa    71580

acgtagaaaa taccttgact aaaggctcag gtaagtatca tagactctat ctaaattctg    71640

aataattctg atttaattct acaggtattt aacagaattt gtaaacctag gcaatgtttc    71700

agctcttcga actttcagag tattgagagc tttgaaaact atttctgtaa tcccaggtaa    71760

gaagtaattg gtgtgaagca ttaggccact cataactcca actatttggg agttgttctt    71820

tgttcgtttg tgtgtgtgtc gtcactgtgt gtataaactc ccctattaca gatatgtgac    71880

agagtttgtg gacctgggca atgtctcagc attgagaaca ttcagagttc tccgagcatt    71940

gaaaacaatt tcagtcattc caggtgagag tggggttaaa caccagggct gactttgatc    72000

ttttgaaaga aagacataaa aaaaaccttt ctttatgcaa ttttaattaa atttgatttc    72060

ttctgttttc cacaatcatt atcaaaagtc aacctttgag tttaatcaat tgcatgggtc    72120

tttaggatga ggatgactac ttggctcaca tctcaacttg aaatcttccc tcctgtctga    72180

gggtttgttt ttccatttgc ttatacagga aggaaaattt caatccattt taattgattt    72240

taaaatactt aggaaagaga tcataaatat cagcatgggg atattgcatg acattgtttt    72300

ttattttttc tcagcaaacc atttctttat tgaaaattat tacaaggtgt cactatatgc    72360

tgtaatttgt tttggtgcca tttatagaga agtggtttgt ttgacaaaca ttagaactta    72420

caaaaattat ttttaaagtg gtttgaatag ccaaattgtt cattttgaca acctaggtat    72480

tctttgagaa tatgttccta tttttaacca tttgctgtaa tatataaaaa caaagtatat    72540

ataaaatagc aaacccagaa ggcttttttt gaattaggtt acttaaggtc attgatttga    72600

tataatgcat gactttctag gaaagcttgt gttttttgtt tcgattcaga ggctttatgt    72660

cattacaaac acttttttct cccattttca ggcctgaaga caattgtagg ggctttgatc    72720

cagtcagtga agaagctttc tgatgtcatg atcctgactg tgttctgtct gagtgtgttt    72780

gcactaattg gactacagct gttcatggga aacctgaagc ataaatgttt tcgaaattca    72840

cttgaaaata atgaaacatt agaaagcata atgaataccc tagagagtga agaagacttt    72900

agaagtaaga atgtccttgc atttgttatt aggttgaaat aatgctaaaa acattgctct    72960

cttttaataa tgaaatgttg ctttcatttt aatcatttca aagctattca aatatataga    73020

aagctgctac agtgtgaatt tgggtcatgt tatatatgat tttcataaat catcctggtt    73080

ctaagctatc tagcagtact ggcaaaagga acacaggata gttccataat tcctaatttc    73140

tatatcataa aaaagaatta ttttctctag agaaataaat gtagccttga attaataaca    73200

ttaaccatta catttaacaa tataatagat tatatatttt atataatttt attatatagt    73260

acatacttat atttattata tataatgtga catatttatt atgatagatt tttatactta    73320

atagattgta ctcataacta taacatctta aagttctatt aatcatatat aatgataata    73380

ttaattatca aatataaaga tagtatctgt atcttgatag tattcctaaa gatttgtaca    73440

aagcaaaatc atttgctcag ctttatcaac atccactttg taaccaatga cgagtttcat    73500

agctgttttt aatggcttcc ttcaatatag gctgatggca agatatcaaa gtttagttca    73560

gtagaattat ttctgtaggt accacatgag atcatctgta tgcactctca gaagtctgct    73620

taattcagaa gtatcaatta gagtttctta cataaagcat gaattgaatg ttctctaaac    73680

aattatcccc tagcatggtg tctctcactg gaacggttga tgaatattgg atgaagatat    73740

gatcaagatt gtactttctg tctgacacct ggaatgtatc tatctgatgg tgcccacgtg    73800

aatacataaa tcttaataga taatttgacc caggtgtggt atggaagtca cgaaaccttt    73860

caaatatatg tgctgttgcc aaaaggaaat gagggaggaa aggtcaggat tctccttaga    73920

taataaaaag taatatacat cattttctta ttttaccaaa tgtgtccttt ctcactcact    73980

gtgataaata aaatcaaata acacctagcc cacatggtaa aagactataa ataaaatgac    74040

agaaaaaaat agaagcctta acaagaaaac tgaaagtttt gaagtaaaat gtttagcata    74100

tatattttta ctaccaccat ttgatgagga atttagcata ttttcccctt ctttttatat    74160

ttaccctctt ttccagtttc tgattgttac aaacatgatt tgaaacttat ttccaatgga    74220

tggagaattt tatttcttaa tttatatgct gtaaaattaa tatatctgat gagtaactta    74280

catttaatat tgtagattat tttaccacac ttatttaaac ttaagttttc tcactgggat    74340

ctgtcctttt attctgagtc ttgctcctat ttctgagttt atactgtgaa tggttttctt    74400

aacctttgtt aaaagaaaaa ttttcaacaa attaaattta gcagcttatt tcagcaatga    74460

aatagtattt attgctgaaa taagataata ataataatga tttaggcagc actcagaacc    74520

aagagaagtt cggagagctc aactcagcaa catgagcagg agtatttata gacagaaaaa    74580

gggagtgacg cacaaaaaca gcttgattgc ttatagcttg acatttgcct tatgtggaca    74640

ttgtctgata aatcagcagg ctgtggttgg ctgaagctca gctgctgtga ttggctgaga    74700

cagctacttg ttacaagaat atactaatag attagaatgc aatttgttta catatgaagt    74760

tagattgcaa ttctctatgt acacagacag cctttaatca aatttaattt aattcatcgc    74820

tttctggaat tgcttcatgt attttttttt ttttttgcta aaaaataata caaaaaaaga    74880

agaaaaaaaa agaaaccccg tctctactaa aaatacaaaa aattagccgg gcatggtggt    74940

gggcgcctgt aattccagct actcaggagg ctgaggcagg agaatcgctt gaactcggga    75000

ggcagaggtt gcggtgagcc gagatcgtgc cattgcactc cagcctgggc aacaagagcg    75060

aaactgtctc aaaaataaat aaattaataa attaataata ataatagagc ccttgagtta    75120

tgtgaattat ctttatatta tatttaaaca tgaatgcatg acaattagct aataatgaat    75180

cttataccac aatcctgtct tccaaatctg tacattattc tttattttct tctgaaatgt    75240

agttttagtg aagaggtgtt taaatcaagt ctgaattttg cttctgtttc ctatgtcata    75300

gaagccattt ttgactgcat aattgattca aactttcatt tattggtgcg tttattacat    75360

ggtttccctg agctatagca ataaatgata gcctcagccc ttgctttcac agagcttatc    75420

atctagtggg aatgaaaaaa aatgtttaag ggggaacaga caaataaatt aaaaatatct    75480

caagttataa taaatgccat gcaaaggaag tgagtctcag gtgctgagat atcaactaga    75540

tgagaagaca tctctgaggt gatggcattt aagctgagat ctaaaagata gtaagaagcc    75600

ataaaatagt ttaagtgtgg gtgtgagtct atgtgtgggg ggtgctgctt caattaggag    75660

aaatagcatg ggcaaaggtc ctgaataaag ggagggtatg ggtttaaaga atggaaaaac    75720

agcagcgtgg tttggtaaga gaaaggaaga atggcaacag agaaagtagc agaaaaaata    75780

ggggtcatat catgcaggac atttcagccc atgggaagga gtttgtattt tattttaaat    75840

gcagtcattt ttattgctgt ctgtcttgtg cacaactgat tgagcaaggg tagatggtag    75900

atgggaataa gaaaggtaag ttgaaggttg cttctctcat ctaggcaaga gaaaataaag    75960

gtttcatcta gagtgatggc agagaaatga agagaaaaaa gatgagctca acatacaaag    76020

tctgtagagc ttgctgatgg attaaagaag acaggaagca ttgaggatga cttctcagtt    76080

tctggctgca ataactggat gggtggtgat ggttaatgag gaaatggtgg acacatttgt    76140

agaggaaggt cactattagc tagctaaaat taaaatgaga tgcctttgag atgtccaggt    76200

ggatatataa tatagagaat tggagattta agtatagaaa tcagagggcc tgctgagttt    76260

ggagataaat tccagagcaa tcagcaaaaa gaaaggacac acacacctct acctctgaac    76320

atccctgata tttttaagta gatagagaat gggaaacctg gtatttaaag caatctggta    76380

ccaagatcta caactctgac atttagaatt caggtagaaa agaggaccca gaaaagaaca    76440

cagagaaaga gccgccaata aagtaagaag caaagatata aataatgaag ccaagagaag    76500

aaaacatatt gtagaaacag atgtgcttgt gtagaatcat gctgcaagat caaggagtaa    76560

ggatgatgaa gaaagaaata tgcattaggt taagtaacag ggaagtcatc agagaatttc    76620

ttgagaaaat ttgggtaagt ggtagggttc aaggtaagaa taaggtgcat acaggggtga    76680

aaagaagagg tcagaaagaa ggtaatatgt gtagacaatt ctcccaagaa atttggctat    76740

aaagggaagc agaataatgg ggcaaatggc tggcatttaa aaaaatatat gggtttttgt    76800

atggatgttt tgctagtgat aatgaatgag tagttatata tgaatcaatt caggagagag    76860

agggagaagt caagtcctcg tgaaagtgaa agagtaaagg ggagcgacag ctccaccgaa    76920

acaggaggaa agatagaaga gaagactgca gagttatcaa aagatgattg agttcaaacc    76980

caatggtttt tatttcctca aagtataaga tgggatcatt gcctgagagt gcaaatgagg    77040

aagagaaaat tctacagatg atttgatgag aatgcattat atatatggtc atatcagggc    77100

atgagaaatt tagtgtattt tgagtgcaaa tttgatgttg gagattactt acttaaaata    77160

taaccattca cttggttgtg agagtttctc caccaacatt cagccatttg gtagccagca    77220

tggaaaagac agatgccaga ttatgtgtag actgtggttc tgccaggtta ggcactgatg    77280

ataatgaatg cccatggatt taagctgtac aaagagtgac aagaacttgg ttgatagatc    77340

atgagaaagt gctaaggcaa atgaattggc aatatttaaa agatcaagga attataatgg    77400

taaaggcaat ctacacagag aacctgagca taatctaaaa gcattttctg gtgcctatag    77460

caaagtattt tccgaaatgc ctttccaaat tcacaatcaa ataaattaac ccactgtctc    77520

acctcctgct gaaaaacata caatttgtag atttcctttg gtgttgctgt ctactttgat    77580

gctcatcaaa cactttttta tgctgctaca gatgaaagtg gggttcatgt gcacagtgtg    77640

tagctaaatg tgcagtatta tggagaaata tactgtggtt atattgggct aaaacaggat    77700

attctcttcc tcctgttttt ctaatatttg acatttaata gagaaagttt tgaaaaaacc    77760

gcaatattgg ccttcactac taacaggaat tttcctatct ccttcatcta cagctgtttt    77820

cttgtgagaa ctacatttgc cagagtgtag agtatcatgt gcaggccctc tgcccagtcc    77880

tgatcccctg cactagtttt ctcagagttg cattatttgc ccttcgttgg ggatatactc    77940

ttcacttcca taggcccaag ccatacacaa ttgtcataag ttgtctttct gagcaagggc    78000

agaattacca tttttttttc tattttgcta cattaatctt gaaaattaat ttaaaaactt    78060

cacccagaat cttcattaga tttaatatca attctgtatt tttgttatat caattttcat    78120

tttccccata cgtattttag tgataagttg gcatttattt acccccaccc acaacctttg    78180

ccgttatgct gcattccctt ttaaaaatag gtttattgag gaataattta tatgccacaa    78240

aattcctttt tttaaactgt ataactcatt ttttaaacta tactcagagt tgtgcaacga    78300

tcgccactat ctaatttaaa atattttcat ctttcccacc aagaaaccca gggcccgtta    78360

gtagtcattc cccatttccc ttttctccca gcccctggca accactaatc tactttctgt    78420

ccctagggat ttacccactc tgtagattta atatacatgg aagcatataa tatatggctt    78480

tttgtatctg gcttcttaca cctagcataa tgttttcaaa atttatccat ggtatagtat    78540

gtatctatgc ttcatttctt tttattgcta aatgatattt cattgtatgt atatgctata    78600

ttttgtttat acattcatca gttgatggac atttgggtta tttccgtctt ttggttataa    78660

tgcataatgt tgctgtaaac attcatgtac aagtttttgt ggaaatacat tttcaatttt    78720

cagttctcag tatataccta gtagtgggat tactgagtca tggttctttt tttttttttt    78780

tttttttttt tttttttgag atggagtctc actctgtcgc ctaggctgga atgcagtgtc    78840

gctatctcgg ctcactgtaa gctccgcctc ccgggttcac accattctcc tgcctcagcc    78900

tgccaagtag ctgggactac aggtgcccgc caccacgccc agctattttt ttgtattttt    78960

agtagagacg gggtttcatt gtgttagcca ggatggtctc gatctcctga cctcgtgatc    79020

tgcccgcctc gacctcccaa agtgctggca ttacaggcgt gagccactgc gcccggccgt    79080

gattcattct ttatctttca gaatcatccc acttttgaat atgcacaagc aatatttcat    79140

ttttctttgc attcaatttt ttcccatttt taaagatgtt aaccttaaat cttcttgaag    79200

ccaaccatct taataattta atgtctagtt gtttagaaat tattgtaaag ttttctacaa    79260

acctagagtg agctacctgc attgctttac ctttcatcat tcttatactg tgttaaatac    79320

agtagtatag cagtgtgcta atagacagct ccagagccca ttcatataat tcagctcctc    79380

agtggttgat aaatgtgaac cagcattagt ttaaaggata attctaaagt aatccatcct    79440

tattaaaata ttttggatgt ttatgtatgc aaaattgcat cttatcctct cccatactca    79500

ctctaccagg cccatccttc ccgaggttca ggagtgtttt caggaaagct tttcatgcac    79560

attttcacct acatttgcac ctcaaactgc aaggctttat tgttttatct gtgtcttcta    79620

agtaagataa aatgatgatg tgtaattcaa tcaatagttt tatctcaaat tgtataatag    79680

tttaactaat tataataact cctgtttttg agcagctagt acagaatgtg tggatcacag    79740

tatcaagtgg tttacatgca atatcctatt tatactattt aacaacttta taaagtaggt    79800

attcttatac gtattttaca gatgcagcag ctaaggctta atggcttaaa gataattcac    79860

ttacttaaga agggatagaa gcaacattca aatccaagaa tatctgattt catagtcttt    79920

cttccatgat tactccaaaa gtctcccaat aatcagattt tttaatttga cctgagtaaa    79980

ataggaagtc aggttcttat agtagaatag atatttaaga gagatgacaa aaggtttttt    80040

agtcatttaa acatttacta tacaaggata gatctgcccc cagtcttagg aacaagcctt    80100

aacagcaaat gacagaagag ttgatgagaa cttttactac taaaaattag cacaaagaat    80160

accatgaaag gtgaaacatg gaaaatctgc attgattaca ttgtcatctc ctcaacacct    80220

agaattagta ggtcctaagt aagtatggac tggtgaatga aaagtaagat aattttagaa    80280

aacaaatttt actcacttat gttactgcct tactgagtct gcctcttccg gagtattgta    80340

ccacataagg atgttttagt caatagcgga ccatatatat aatggtgatc tcataagatt    80400

ataatactgt atttttttac tgtacctttt ctgtctttag atacacactt tccattgtat    80460

aacagttgcc tacaatattg agtacagtag cccactctac aggtttgcag cccaggagca    80520

ataggctata ccacatagcc taggtgtatg gtagcctata ccatctaggt ttgtataagt    80580

gcaccctagg atgtttgcac aaggacgaaa cgtcctaatg atgcatttct cagaatgtat    80640

cacagtcatt aagtgacaca tgaccgtacc tttaatcata cttaaaatcc aaactcattt    80700

ctatgatatg caaattccga catgatccgg cccctgccta cctctgccat cacaatcctc    80760

cctctcacca cactgtagcc acactggcca tcttgctggc ttttccacac accaacttca    80820

tctctgcctt agggctttag ttctttctct tcccccagcc caaatatctc ttcaccagta    80880

ttttcatggc tgtcttcttt gtcacactta ggtcttagtt taaatatcat ctccttagaa    80940

agaccgtccc tgactgcagc ctaccacgtt gccttaattt attttcttta gatcatttat    81000

cactatctga aaatatcttg tatatttatt tatttactta aatttttatc caaccacaac    81060

ctccaccctc acctaaacat aaaggaggtc tcataaaact aatgatttta tttatcgtgt    81120

ttattgtcat gtttattgcc tagcctctaa gagattatca ataaatattt gagggagaat    81180

atatgagaaa atagtaaata aatggatgca tattgcctgg gaccaggcct gaatttgtag    81240

ataaatgtct atatcaatta atttacctcc tttatcacaa tcacagatta aagtctgtga    81300

tgttataact gttcaaattc ttcttcaaca gaatattttt attacttgga aggatccaaa    81360

gatgctctcc tttgtggttt cagcacagat tcagggtatg taatatttgt tttcttttta    81420

gtctaaaggc tgaaagagaa ggaaaagaat gttcagtcag tttgcaaatt agtctttgat    81480

tctatattgc tttttatata tttcatggta ttatttgact cattctgtcc cacagcaaat    81540

ccagtcttta aaatgttcac agttaatgca tactcttgaa agcaagactt tgagacagtg    81600

ctcgaattaa cacaagacag aagtcatata aatcttaaga aggtagaaaa tgttacttct    81660

agaaaactcc accaaaagtt ggttggataa tttcaggtct tctttctgga aaacgaagag    81720

tcacaaagtc tatttttctt tctactccca agttccactc attctccaat taaatgtgac    81780

tcataggtga ctgaatgtca tgttttggcc actctaagca aagggattcc ttggacttgg    81840

gtacacatat tttaagaata ttgtatatat aagaatattg tatatattca actgtccatc    81900

ttgctgcttc tctcttacac caacttcatt ttgtagcatc agctgcataa gctcttgctt    81960

ttccccctat gcagacatct attcatcagg ctctgtgtac actggcaaca taggaataaa    82020

ctggataagg ttgctgttcc cagaagaatc tcagaatatt gtatttattt aatggcatca    82080

ggaaaaacca gtccaccaat tttagaaaga aaaaagtctt aaagctgcac atttttatga    82140

acttagacaa ttactatatt ttgactatta ttgactctaa tctattccaa gaattataca    82200

gacagaaaga gctttggtaa cagcctacat atcaatattt actgaaccaa gaactatcac    82260

aaaacgtctg ttgaaaattt ccatgtttta atgatgatga tgctaatggc agctatgatt    82320

tattaaacac tttctatgtg caggatgtaa gctaagtaat ttgtacacat tatcttattt    82380

aaacttatta caagtcttat tttcttgagg tagatgttat tatcctattt tcacagacag    82440

acttatgcct tgaagaattt ggtaaagtca ctaagtagtc agtagccaaa tcatgtattc    82500

ttaatcctta ttcaatattg tccccctata gaagaaacct tgagtttgta acttttcagt    82560

aaggctattt agcttgtgtc ctgaagacac tctcacctat aatgttcttt ctcgtgtgta    82620

gtcagtgtcc agaggggtac acctgtgtga aaattggcag aaaccctgat tatggctaca    82680

cgagctttga cactttcagc tgggccttct tagccttgtt taggctaatg acccaagatt    82740

actgggaaaa cctttaccaa caggtgagta ccaagagaaa catgcattgt atttttgaat    82800

ggcatatgta cctggtgtat gttaagagcc tgtattagga ggttttttat ttatttgaga    82860

atggaggaaa ctctattatc ttattaccaa aattataagt gttttactcc catcactaat    82920

aatatgggta gttctcgaat cataaataat tttcttatct tttctgggca tatttaatct    82980

ctagatctct cgccttcctg agtatatcat cccatggggt cctagttaag taccaggaca    83040

tactgtaatg ttttctcaag ctgctcctgc acatggactg ttttccatgc gtgcttggga    83100

tggcctgaag agaagaggct ctctgatgtt cacctgctca ccatgtttta tttttgaact    83160

cctatttaaa gttaaagatg caattcattt ctctaagttt ttctctccca aatcaattgc    83220

tcccaactgt agacttccat gattttttgt attttcttcc atttatatca ttgatctctt    83280

gtattgcaag tggtaattca tgtggctatt tcctctaact tgaatgtgaa cctcttgggg    83340

ctgtggtctc catttacttg tatagtctca gcagccaagc caaaaggaag gagaccaaaa    83400

tgattattct atagtacaca taacaatgat tcacttttct cagaatagct gcagatctgt    83460

ttttttttct tttttggcct attttatatt tactttattt ccgagaatat tataaatgaa    83520

ttcggaaatt atgtaagatg cactttacag caaaaatggg aatgcaaata ttttttaaat    83580

atgcaagaag tggtcacctt tactcaaaat taaagaaaca caaataaaaa aattaaaata    83640

atttttcatc agaggtaaga cttatttttc atttaatatc agttgatact atcctaaatt    83700

cactttaaaa tgctttgtat gataaaagta tattacatta tacaattatt aatagaaatg    83760

ttaattatct tataaatttg tttaagttac ttgtagattc ttaatattag acctttgtca    83820

gatgggtaga ttgccaaatt tttctcccat tctatagttt gcctgttcac tctgatgtta    83880

gtttcttttg ctgtgcagaa gctctttagt ttagttatat cccatttgtc aattttggct    83940

ttggttgcaa ttgcttttgg tatttttgtc atgaagtctt tgcccatgcc tatttcctga    84000

atggtgttgc ctaggttttc ttctagggtt ttcatggttt ggggttttac attaagtctt    84060

taatccatct tgagttaatt tttgtataag gtgtaaggaa ggagcccagt ttcagttttc    84120

tgcatatggc tagccagctt ccccagcacc atttattata tagggaatcc tttccacatt    84180

gcttgttttt gtcaggtttg tcgaagatca gatgcttgta gaagtgtggt gttatttctg    84240

aggtctctat tctattccat tggcctatat gtctgtttgg gtaccactac catgctgttt    84300

tggttactgt aacctcatag tatagtttga agtcaggtag gctgatgcct ccagctttgt    84360

tctttttgct tagaattgtc tttgctatat gtgctctttc ctggtttcat atgaaattta    84420

aagtagtttt ctaattctgt gaagatgtca atggtaattt gatgggacta gcattgaatc    84480

tataaattac tttcggcagt atggccattt acatgacatt gattcttcct atccatgagt    84540

atggaatgtt tttccatttg tttgtgtcct ctcttgtttc cttgagtagt ggcttgtagt    84600

tcttgaagag gtctttcata tcctttgtaa gctgtattcc taggtatttt attctcttta    84660

tagcaattgc aaatgggagt ttattcatga tttggctctc tgcttgtcta ttgttggtgt    84720

ataggaatgc ctgtgatttt tgcacattga ttttgtatcc tgataccttg ctgaagttgc    84780

ttatcagttt aaagagtttt ggggctgaga tgatcgggtt ttctaaatat agaatcatgt    84840

catttgcaga gacaatttga cttccggtct tcctatttga atacccttta tttctttctc    84900

ttgtctgatt gccctggcca gaaattccaa cactatattg aatagcagtg gtgagagagg    84960

gcatccttgt cttgtgccag tttttaaagg gaatgcttcc agctttttcc cattcagtat    85020

gatattggct atggagtttt cataaatagc tcttattatt ttgagatatg ttccatcaat    85080

acctagttta ttgatagttt ttaacatgaa tggatgttgc attttattga agaccttctc    85140

tgcatctatt gagataatca tgtggttttt gtcattggtt ctgtttatgt gatggattac    85200

atttattgat ttgcatatat tgaaccagcc ttgcatccca tcaaaaagtg ggcaaaggat    85260

atgaacagag acttctcaaa agaagacatt tatgcggcca aaaaacatga aaaaaagctc    85320

aacatcagtg atcattaaga aacgcaaatc aaaaccacaa tgagatacca tctcaagtca    85380

gtcagaatgg tgattattaa aaagttgaga aacaatagat tctggtgagg ctatgaagaa    85440

atagtagcac ttttacactg ttggtgggag tgtaaattag ttcaacaatt ttgaagacag    85500

tgaggcaatt ccttaaggac ctagaaccag aaataccatt tgacctagca atcccattac    85560

tgggtatata ccgaaacgaa tataaatcat tctactacaa agacacatgc acacatatgt    85620

ttattgcagt actatttaca atagcaaaga gatggaatca actcaaatgc ccatcaatgt    85680

taaattgtat aaagaaaatg tggtacatat acaccatgga atactatgca gccattaaaa    85740

aagaatgaga tcatgtcctt tacagggaca tggatgaagc tggaagccat catcctcagc    85800

aaactaatac aggaagagaa aaccaaacac tgcatgttct cactcataag tgggagttga    85860

acaatttgaa cacatggaca cagggagggg aacaacacac accggggcct gttggggggt    85920

gggaggcaag gggagggaga acgttaggac aactacctaa tgcatgcagg tcttaaaacc    85980

tagataatgg gttgataggt ggagcaaacc accatagcac atgtatacct gtgtaaccaa    86040

cctgcatgtt cttcacatgt atcccataac ttaaacatat gaaaaaaagc tcatcatcac    86100

tggccattag agaaatgcaa ttcaaaacca caatgagata ccatctcatg ccagttagaa    86160

tggtgataat taaaaagtca gaaaataaca gatgctggag aaaatgtgga gaaataggaa    86220

tgcttttaaa ctgttggtag gagtgtaaat tagttcaacc agtgtggaag acagtgaccc    86280

agcaatccca ttactgggta tatacccaaa agattacata tcattctatg gtaaagacac    86340

atgcacacat atgtttattg tggcactatt cacaatagca aagactggga accaacccaa    86400

atgcccatca atgatagact ggataaagaa aatgtggcac atatacacca tggaatacta    86460

tgcagccata aaaaagaata agttcatgtc ctttgcaggg acatggatga agctagaaac    86520

catcattctc agcaaactaa aacaggaaca gaaaaccaaa caacgcatgt tctcactcat    86580

gagtgagagg tgggcaatga gaacacatgg gcaatgagaa gatcatcaca cactggggcc    86640

tgtcggtggt ggggggcaaa gggaggaata gcattaggag acatacctaa tgtaggtaac    86700

aggttgatgg gtgcagcaaa ccaccatggc acgtgtctac ccatgtaaca aacctgcacg    86760

ttatgccaaa aaaaagaaaa aaagaaaaaa aaatctctgt accttcagtt taattttcct    86820

ctaatcctaa aactattttg aaaaaaaatt ctattttaaa aagcaaagaa agcgaaaaaa    86880

aaagttaatt gaaaatacct atgagatgaa taaagtaatt aaataagacc atctgcctag    86940

tgttaacatt caatgatatt attaatattt gatgataaag aaagaaaaga tagaatttta    87000

acagtaaaag ggactatgga tatcacctgt tcctaaaatt tgaaagtgag caaaggattt    87060

aattttatga gtaattttca gactgtagga aaaaatgcat gatttttata ctactacact    87120

taataatcaa gaatcttaca tgactttagt acaagcatat tacattgcta tattcttcgt    87180

actgaaaatg tgtttaatat ttgttttcca tgaagatata acttttctct ttatattttt    87240

gataacatga gattatacca aactgtcaga tttgctcatg cctgtcaaat tgaaataatt    87300

tactaaaaaa actttttatt gttcaaatga caatttccat ttttccctag acgctgcgtg    87360

ctgctggcaa aacctacatg atcttctttg tcgtagtgat tttcctgggc tccttttatc    87420

taataaactt gatcctggct gtggttgcca tggcatatga agaacagaac caggcaaaca    87480

ttgaagaagc taaacagaaa gaattagaat ttcaacagat gttagaccgt cttaaaaaag    87540

agcaagaaga agctgaggta ctgttatttg atttaaaatt cttcctagag gtagaaatgc    87600

aaacggttac aacagaggct ctgcggtata tgcttggcct tctccagcta gattttcttt    87660

aatgaatttt tgtgtataaa ctgtatcctc atttctggtg tggaaaaagg aaccaattct    87720

gggctgagct agaattgata ctttccccat aatcatctca ctgcatgaaa agtgatctaa    87780

ggctgttcct cttaaacctt ttacctacaa tgacttagtg tgtgtgtgtg tatgtctata    87840

tatacataca catatacata taaatgtgtg tgtatatata tatatatata tatatatata    87900

aacacatgga actatgtgtt tttttaaatt attatatcat gaggaaaaat cttttagaat    87960

aattgattaa ataatatagt cagatatata atatatatat aatctcaatt tatatatata    88020

tacaatatat atatgtatat atatacacac atacacacaa tggatttccc cagagtacca    88080

attgtataca gtggtttcat gaaaattatt ttaacgttaa aattaacaga tactcttcta    88140

tggggtatga ctaaaacagt gcatcatgtt ttgttaatgt cacaaggatt tttaagataa    88200

aacatgagat attaagaaaa taattttggt gtggctaatt taggttgtca tagattctcg    88260

aaagtttcct ccttaatcct ctttccagag agattcttca gtgtaaatgt ttgagaaggc    88320

ttgtactaag agaaacataa tttcaaatgt actgcagttg ccttaacatt tgtctgaagg    88380

tttcacctag ttaaatctct tcaaggagtc taatgtatta ggggagggca atcatctgca    88440

atgcagataa attctgatgc acaaatattc agtgcagcat tttaataatg gtaaaaatca    88500

gaaaaaattt aaattttgga aaattagaaa ataactaaga aaattatgaa aattgtatat    88560

cttaaagtat tattttgcca tagaactatg tgttttttta aaattatttt atcatgagga    88620

aaaatctttt agaataatga tggattaaat aatatagtcc gatacaatct caattttaaa    88680

attatacata catataaaaa gaatggaaga aatattagca ccaattattt ctgggaggta    88740

agatgacttt ttttctgttt ttcatttata tctttatttc ccatgttttt acaagaattt    88800

tttagtgttt ataaacaaaa cattttgtaa agggatagta ctaggttatc ccaggtacta    88860

cctagggaat tcccagaagt ttcatttagg ccaatagtca ttgaccttac cactttctta    88920

caatattatg ctttaataat tcatttattt ttcaaataac tcaatcttta ttaaaccata    88980

gagtgcctga ttctattgat gatatggagt taattgcctg ataatcaaat tgtctgtctt    89040

attgcatggt ttatgcgagt tttacattcc aaaattacct tgtaaaactt taacatataa    89100

tatttaattt gtctttactg taagcaaatt aataacatgt aatagtttaa ttctaaaata    89160

caatagagct ttatttcaac ctgagacaaa aaccaaatat atactttgta agcattctga    89220

tcattgtgta aagaaaacga tcatttcatg tttaaaggac atgattatat gcaccatgtt    89280

gttatgctaa taggtgaaag atgtcctgtc ctagggtttc ctaggatttg gaaatgactc    89340

atttaagtgt taacgtcttg gcccaaccag gcaattgcag cggcagcggc tgaatataca    89400

agtattagga gaagcagaat tatgggcctc tcagagagtt cttctgaaac atccaaactg    89460

agctctaaaa gtgctaaaga aagaagaaac agaagaaaga aaaagaatca aaagaagctc    89520

tccagtggag aggaaaaggg agatgctgag aaattgtcga aatcagaatc agaggacagc    89580

atcagaagaa aaagtttcca ccttggtgtc gaagggcata ggcgagcaca tgaaaagagg    89640

ttgtctaccc ccaatcaggt accacccaaa ttgctaaatg tgtatcaccc gaggcagaat    89700

gctagagaaa aatgtcttat tttagggtaa gagaactcgg gagaggatag tgagtgattt    89760

cattggtatg attttaggta aaaacctagt atcgctaggc atttatggaa agatgtacac    89820

aggtttccat ttgggttcaa tcatttttga aagaccttat agtttcagaa ttgtcaatat    89880

attctctaat aaactaattt tcagaagcaa aatgttcctg agaaccattg tagaaataaa    89940

gagaccattc acactataga ataactttta tatttgtatt tagtctgtgt tttgtaatgc    90000

ttcattggtt aaaaactaat cttagactag tttctcttct ttcttaaaca gtataggtaa    90060

tagtatcact cacccatttg gaactttgga gaagcctttg atatcctcca cccccaacca    90120

catcaactac taatatgtag tgccatagtc tgttaattct gtttatgtgg aagttctctt    90180

tccctttctc ttttcactga aaccttcatc tctcaggcct ccctgcttat aattctgcac    90240

aaatccccaa gatgaaccat tgcttctgtt ttccttaggt cttccctgtt ttccatcaca    90300

caaccccaca aatcactttt ctaaactaaa aatctagtta aaaatctaca agattctcct    90360

gatatacaca gtaaaaaaag atagagtccc tgccttcaaa atttcacttg aacctaggtg    90420

atgatacaga acttggacac atatatcaat aaaaataaat atgacaggag cagtccaagc    90480

tggttttgag gcaaagacct taccatactt tttccattgt tcacaatagt tgccactttg    90540

ttctttacat agtaagcact aatgtctatt gaactagatc cttccaaagg atttacaccc    90600

tggacatgag tcatataagc atgaattgaa tttttcctcc tctttggtat tgggcaactt    90660

ctttttaaat atttaatgac tttataaatt aactggtgct aaaagctctc tttaaataca    90720

ctttaactga gctcttagta tgtaaggtgg attttcaatg caaagaacca tacagcatga    90780

tttccaattt ttttgtgaag cctggggatt gatatataaa aagttgaatg accagtagca    90840

atactaagtt ctttttttaa gttataagtt ctgtgcagca aaatgaatgg cattaaaaga    90900

atggagcagt aactctaggc cagaatatta gagagctgta tagcaacaaa taatttacct    90960

ggtcctgaaa ggatgaattc tacaaattgt ttcatccctt aagtggaaga agttttcttc    91020

tcactgaatt gcttcgtttt taagtatgtt tcttttaagt cagtacagag ccacctgccc    91080

tcaggccagt gggttcagtg gtatttatat gaagtgtact tctatcagta ggtgcttcag    91140

caaccacgtt ttttttaatt tttctgcagt caccactcag cattcgtggc tccttgtttt    91200

ctgcaaggcg aagcagcaga acaagtcttt ttagtttcaa aggcagagga agagatatag    91260

gatctgagac tgaatttgcc gatgatgagc acagcatttt tggagacaat gagagcagaa    91320

ggggctcact gtttgtgccc cacagacccc aggagcgacg cagcagtaac atcagccaag    91380

ccagtaggtc cccaccaatg ctgccggtga acgggaaaat gcacagtgct gtggactgca    91440

acggtgtggt ctccctggtt gatggacgct cagccctcat gctccccaat ggacagcttc    91500

tgccagaggt gataatagat aaggcaactt ctgatgacag cgtaaggacg ttttacatag    91560

ctcaggcatg gctgggccct tgttcctgca tcagtcagtc tctctgctga agggccttct    91620

ctggtcttgt gaatggctct gcattttgca atactttttc tataggaaca cacctttgat    91680

tcattagcct aatcctcatt ctatgtgttg taggcatcta actcaaagat aaaatcccat    91740

ttttgtaaaa aggtacttgt ctattaattt tataattgaa gattataaat aatctcttta    91800

gagaacaatt tatgacggat acatatatag atagatatca gtacagaaaa tgcaaggata    91860

atgctgatat tagttaataa tagatcccat ttctatgaag aaatttggat tacttgccag    91920

ctactgctat ctttttcagg tcacagctta atatgtacct attccaagga atcttatttg    91980

agttgttaat aacagcaaac acatatttag tatttatgac aaccccatga gatgatacat    92040

tattatctct gttttacaaa tgggaaaatt gaggcatggg gaaatgaagc aacttgcccc    92100

aatttactca gctaataaat ggtagctcct aagttgaaac ggaggctgtc tgtttcagat    92160

cttgtgctct taaccactca ctctgctatc tctccaatgt gcagtaggct tcttatcttg    92220

aaaaaattta gaatggctat gtattaggtc ctccatataa atgaaacata actgttttca    92280

tttttaaaaa atatttcatc tggagtctat gaatcaaaac aaaatatctg aaatgcaagc    92340

attgacacaa acaaacataa aagcaaaaca atcattttac agcagttcca aaggtctacg    92400

agtcactaag tggttagaga aaggtgtctg attaggcttg aaagtgagat ctttctcatt    92460

cctggagttt ccaggatatc tctttagccc actcactatg ctatgctgca ttaccaatat    92520

cagcaagggc tttgactaac ccaataagct tcaaacatat gctacatgct tatatattta    92580

tatttgcaga caatgtagta tttcaagtga gagtaaagtt ccatcaaatc catggccaca    92640

catatatttc aatttgaata aatgcatgtg cttttaggta acatgtgacc tctatgtgtg    92700

catgatacag cttaagccct tctgcaaggt atttttcatt attgaatgag catgttaaat    92760

ttctgtggaa tcaaactttg cttgcatttt gttttgcaat tatgtgtgta atatgtaaaa    92820

tactatataa tttatatcag attaggagat tatttcatat ttttaatgaa gtttcttcat    92880

ttaagagttt tttcaccata gaaaaatcag tatcacaata aatcctaaag tgaaaactac    92940

aaaactagag gaattagtgg atacttataa gatacaatgg aaatacagta aacataaaat    93000

tgtggcacaa tatatggttt atatgaaaac actgcataac taataacgtc atctctatac    93060

ctgaaacatg tctacatgga aaataatttg tttaatctga caaattcttg tttgacagac    93120

tatagcacag aaaacctggt tttcgagact tttcaaaaag ttgacttttt acagagatct    93180

ctcaaatggg tgtgtctgtt cacatacaca tagatgcata atacacccat gcacatatct    93240

atgcctgtat gtctgtgttt tgatacacat acatgcatga ctatacctat acaactatac    93300

aactttacaa atctagaaat atatatttaa aatatatacc acataccaca cacaagcaga    93360

caaacatgat agatctagag ttgtatagtt gtttgtgtat atatgtgtgt gtgagtgtgt    93420

gtgtgtattt ctggcctgca tggaaccaac atagtgtttt aaatttgaat tagtttccaa    93480

gttttaaaaa taagacattt tctcacaaaa ataaatacac ttgttatgca tgagttcatg    93540

tttttgcatg gcaacaattt ctagagctga agagaggtca cctctttcag atgtagcttg    93600

cattctccat ttcactaatt gttcctttca aactgagtca tttatcatca tatgctctgc    93660

tcagttcatg aggtcttcct tggcagtaag agacaaccat tacaggagct tcattaatgt    93720

tgttccctca ataaaaagta attccagaaa tttatcagag aatactgaga ttctacccct    93780

ttagatacac agcactacag cactttcact gttttcatgt aggactgtca catgacaaac    93840

tatctgaata aattgaacac tcagaaaggc agagaggtga tgatagtgat gatataacaa    93900

aaaagcagct agctttattt tttatctcat aaatattaat tcctttaatc ctcacaagaa    93960

tatgaagcaa gcactatgat tatccccatt ttaccaatat aaaactgaga cagttaagta    94020

gctctcctat gatatacagc cagtaagtag cagagccata atttgaaccc agcaatctag    94080

gctctacttt taattactca ctacagctat ataagcaaga ttttatctta tacctacaat    94140

ttattaggat tctgttctta agacattaat tgattttttt tttagggcac gaccaatcaa    94200

atacacaaga aaaggcgttg tagttcctat ctcctttcag aggatatgct gaatgatccc    94260

aacctcagac agagagcaat gagtagagca agcatattaa caaacactgt ggaaggtatg    94320

taataatctt cttttactgt acagattctt aaataaaatt aacataaatc tggtcaacct    94380

taaataggca catgaaattc ttaggaagaa ttcagagacc ataaaatggt tttaaatgat    94440

ggtaaagata accaatggat actgatggaa ttgtttttat gtgcttaaaa atggataaaa    94500

ttatttgcta ttaaacacag acattgataa catggcaaaa atgactttgc aaaatgaaaa    94560

aaagaaaacc cacaaagaca gatgttgggt gatctgacct ttcaaagata agtgatttaa    94620

tagtaattga tgcagaaaac aaggttaacc cagagctacg tgattctgtc actatataat    94680

cttacaaatt acatattcgc tcaaaaattg tctcttctaa taagcaaaga tagtcaaagg    94740

gtgacaactt tacaaactgt gctggcttct accctctccc ctgacaatat gccccaggtc    94800

ccacctggtc cctgggtcta acacttcacc ccccacattc ccattgtggg ggcaaagtgt    94860

ctactcatct cctaaataaa tggtgagaag taaatgggct aatggtgtga aatgtctatt    94920

tcatgagtcc tccataaatt atttctagtt gcttggttct aggattgttt tcacctgtga    94980

actattacag caagagtttt ttctggacag aatagtctca tcttattgtt gtcatgggac    95040

taaaaacaca ggtgaaaaat atgcatattg gtggaaaaca tacatttctc tgttaaggaa    95100

acatagttct cctgtttacc atcacatgtt aggtgcattt ttctctgaaa gatgcccaca    95160

tatgtgcttg cagtcataaa tttcacttcc ttaccctctc ttatgcttca tctaggcaac    95220

gaacatgtca taatagactt acataagagg ctatgctttc attgaaatag tactgttaaa    95280

ttttcaaaat ctaaactata aaccttgttt caatattaga atgcctgact gatttgtatc    95340

tggttaggag tgaaacagac aaatggctga ctccatgttc tctgcttttt tctcccagaa    95400

cttgaagagt ccagacaaaa atgtccacct tggtggtaca gatttgcaca caaattcttg    95460

atctggaatt gctctccata ttggataaaa ttcaaaaagt gtatctattt tattgtaatg    95520

gatccttttg tagatcttgc aattaccatt tgcatagttt taaacacatt atttatggct    95580

atggaacacc acccaatgac tgaggaattc aaaaatgtac ttgctatagg aaatttggta    95640

agtctcttat tgtgtgttat gtactcatag tttctctttt tagttgtcat cattgtcatt    95700

tcatattttt tatgtcagat gaatctgcag cctcagaatt atgcatatcc agaactttcc    95760

atatgaatgg atgtgtagag tcaagtttct ggttatgtct tttaaaataa ttgtgcagta    95820

ctgttgaggt ctacaaataa caatactatt tctataaaag gttaccatct tgggagttga    95880

taatgatttt ttctgccagc atatttcttg ggagcaacac ttaacatttt tggttctttc    95940

tcacaccttc ctaattacat tgctgctttc ttgtaagtac acacctcaca tattttcaga    96000

aaacctatgg atgtattgct ttgacataat agtagtgaag tgtttgggtc ctcagagtcc    96060

caaagtcctg ggtttgaatg ctgattctgc attatatgag tgatatgccc ttggacaaat    96120

attttaactc tgtagtattt aattttatca tttataaaat aatacttcat tataaaataa    96180

ttatttataa tataattgta actgtatttc atttatcata ttcttgggag gattaaatgc    96240

tttctgctta ttagcctggc atatagtaaa tacacaataa attaaagcta tcatcatcat    96300

caacatcatt gtcatcaaaa cttcaaagac ttaatgaaac aagctttaaa aacaactatt    96360

ttgagaaacc aaaatggttg aactggacat agaagactca aggataggca agaaggtgat    96420

caacagactt ctggaagata taagatccaa ttagtaaaat tgatgccaga gtgatctcta    96480

aaatgtacag tgctggtcac actaactcag ggtaaacaaa atgccagttt ttgactatgg    96540

atgtgaggca ggcaccagtt catttttagg gccagagaat ctcagcttat gactcttcat    96600

aaaccatgaa taactttggg tatctttgtc aatgtctata taagataatt ttgcttttgc    96660

tgtggtccca aacaaattga catttgaaga ccagaagttc ttttctgagt ctgtcttttc    96720

ttctaaattg tctacaaata ttcccaatgt ttttccccat gtgctcgctg agttagcatt    96780

cttcttccct tctatttatc tttggaaaaa ggcaggaata tctagtttct aattgttggt    96840

ggagatccgg atcttgcaaa taagtacctt ctcactgaga cgactgcatc cctgtgaact    96900

cagaaaggat ttacctggtc acagctatta ccacaacctc aagtccagct gctccctgcc    96960

aatcttcttg atcctgcatt atttgaaaat tgactcctgc agttatagac ctaaacattt    97020

cccttagaat cttctttggt cagattcctt gagtcaaagt gtacccaaag gattcatttc    97080

ggtgttgcct ttttaagtga gtcctttgat accagtatca tgaattaatg atattttgca    97140

atgcactttt gtgtcaaagc tttagaagta ttactttagc tgccacattg tcaattaaat    97200

acttttttct cttctgctga taaatcttta aagagtgagt caacatgttc tttattactc    97260

taacagtagt cagatcagaa aaaaaaagac tggctcaaaa tttcagtatc aacttatgtt    97320

ttctttttat cttcttccag aacaactttt tgacccacat aaattctttg aaaatagtga    97380

ctgtgtcaat taccaaatgt tttactcttc tgaaatttta atatgctatt ctaaaatgct    97440

gtctaaaaat gatgagcact gacaggacag ttagagcttt tcaacctttt gatgctgata    97500

tgggagccag ggaagagcaa tacctaattt acaggactaa gttagataag aatatccatt    97560

tataaagtat ttagcaaact gtctggaaca cagtaaatgc taagcaaaca gtgattatta    97620

tcattgtgtt gatttcctgt tttctaatat taacagaaaa acattatttt tctcacttag    97680

gtctttactg gaatctttgc agctgaaatg gtattaaaac tgattgccat ggatccatat    97740

gagtatttcc aagtaggctg gaatattttt gacagcctta ttgtgacttt aagtttagtg    97800

gagctctttc tagcagatgt ggaaggattg tcagttctgc gatcattcag actggtaaac    97860

ataaactaag gttgccatta tattctataa taaaggggta tttctttggt tttgcattat    97920

ttttaaaaac ttttgggaat ttgaatcaaa aggcaagatt atatcttgat atctagtaaa    97980

ataaaatcca ttcattgaca aatgcactta aagaactaaa accacatgaa tatttttaca    98040

atttttgaag acatgctcaa ttctaatttg aagtacacgc taatataata taaatatttt    98100

ctattaatat agtacaataa tttatttcag agtaagaagc ttgtggctta cagaatttca    98160

atgattatat gttcataact ttatgaattt ggtaattaaa gatcaaattg ttatccccca    98220

aaacaattgt tgtctgatct taacaatata aaaacaaata aagacttttt aaagcacatt    98280

cctctaatat gctagatttt atctaagtgt cggcatgaga aaatgtatga aagtattaga    98340

aagtagaatt aaggataaat tatcaattct aaaagaaaaa tatcacaaat tatgataaga    98400

ggtttctata gcaatcctga actaaaagta catagtttct tcataatatg tgttgtaatt    98460

ttttgtggca agtggaacaa aataacagag atattgaaaa ttgatgaaaa tgaaaaataa    98520

gaatatttta gctggataat aatgacaata ttataggact taaagtctgc tttacccttt    98580

gaacaaaaat caagattgga aacattgaaa agattttcat agtgattaac attaaacttt    98640

atatttgctt ttagctccga gtcttcaagt tggcaaaatc ctggccaaca ttgaacatgc    98700

tgattaagat cattggtaac tcagtagggg ctctaggtaa cctcacctta gtgttggcca    98760

tcatcgtctt catttttgct gtggtcggca tgcagctctt tggtaagagc tacaaagaat    98820

gtgtctgcaa gatcaatgat gactgtacgc tcccacggtg gcacatgaac gacttcttcc    98880

actccttcct gattgtgttc cgcgtgctgt gtggagagtg gatagagacc atgtgggact    98940

gtatggaggt cgctggtcaa gctatgtgcc ttattgttta catgatggtc atggtcattg    99000

gaaacctggt ggtatgtaac cagatgttca tgcattttaa tttctctgtg gaaattattt    99060

tgtgatgatg tgatctatta tttttataat tttataatta attatatcta caattattaa    99120

ttgcaaaaga atagtgataa ttttaataca agaaagaaca ggaaagagaa cgaaattttg    99180

tattagtttt cctagccaaa taacccatat ttatattttt caaaatcact gcctattcat    99240

tttaaggcaa aggtttctat ctttttctct aattttgaaa gtgatggcat atgctctctt    99300

gaagctatac tagtaaataa aatataatta agttaataat aacaaaaatg aagttaataa    99360

tggaccaagg caaatgaaag gactggtccc gcaccttata gccatgtgta agactagcct    99420

ctatagcaag gatcagcacc tatgccccac agaccaaagc cagtccaatg cctgttattg    99480

tgtggccctg ggagctaaga atgattttta catttttaag tggttaaaat aatcaaaaga    99540

agaataaatg acacatgcac attatatgaa atgcaaattt tagtgttcat aaactttatt    99600

caaacatagg aatgtcaatt catttacgta tcttctatga ctgcttttac attacagtgg    99660

cagaggtgaa tagctgccat agaaatcgta tgcccaataa agtctaaaat atttatcatt    99720

tggcccttta cgaaaaagtt ttccagccac tggcctatag catcgcgtgg acatagcaat    99780

ctgcctactt tttgaattag tgttttcttg gcttgtactt tttttttatt ttttttcttc    99840

cttatactga ttagtgaaaa ctttcaagct tacaagcagg agaaaattgg gataaaatgc    99900

tcttctatga gccactcatc tcaattctca aatctgccac gttgacttgt cacagttggt    99960

cagcttgaca tcaaatctct catcaggtat ccagaaggtg ggatatggta acagccatat   100020

ggtaagtgcc ttcacttccc actgagttga aaaaaattac taaaatattg ttgtccttgt   100080

aaccaccata aaaagaggat tcagaagtca ggacagaaac ttacattcat ccagtcacac   100140

actaaatgat actgtgccag acatacacaa aggcatttat gcagcacaaa ttctagattt   100200

ttactgcaca aaaaatatac atcctggatt accattctat aattgttgat caccctcaag   100260

ttgtagtaat aaataagctt cctagtttta tatagcctta caaattcctt ccaatatgga   100320

atgaaatgca cattctcttt gtttcttctt ctctgttttg tatttataag ctcctatagc   100380

aggatttgct tgtgtatttt tttttttttt gagatggaat ctcgctttgt tgcccaggct   100440

ggagtgcaat gatgtgatct cggctcaccc caacctccac ctcccaggtt caagcaattc   100500

ttctgcctca gcctcctgag tagctgagat tacaggtgca tgctaccgtg ccagctaatt   100560

tttgtatttt tagtagagac aggttttcgt catgttggcc aggctggtct cgaactcctg   100620

acctcaggtg atccagcctc cgtcgcctcc caaagtgcta gaattacagg cgtgagctac   100680

tgcgcccagc tgtgcatttc ttcttacaaa attttgacat aaaatcgtga aattgggaaa   100740

ggtataactt gtgaaaacat gccacatcaa agccaataat cacaaataat ttaaatgttt   100800

attatttatt caggcaaatt caaagggaaa ggcattccct tggctctcac cacattttcc   100860

actcaatatt ttttagtatc ttctctgtga aaagaaaggt atttaggtat tgtttagata   100920

ggaaggcatt gtttaggtat tatttagggt ggaagaccaa aaccaattac ccatggtcta   100980

atccttgttt ttaagatgct tattagggca cagaaaagtg gaacacaaaa gttatcagac   101040

aaggaagaag tgatgagttc taccaataag gttaaataaa atgcttctga cacttaaaga   101100

aagagttcta gattgagact taagggaggt ttttgaagtg ggcctttgaa caatggataa   101160

tataatattt gatcatggac actggtgtga gagttatgtt ttcctttgaa aggcaatata   101220

gatttatagt aaaaaacaga ggggatatat tggtgagtgt ttcattcgtg tagaattagt   101280

gttaactaac tcatattatt attctttaat tattaattct tggcaaagaa agtatacaga   101340

agaaaattca taaagttgat aaccaactct tgactaatgg aggaactacc aatatcatag   101400

aattaaaatt taaggaaaaa aatatattcc tgatatagcc ttccacatta gagttatatg   101460

ctaaactggc ttctcttttt ttatatttct ctaatttatt cttttgatca ttttattgcc   101520

agttaattga aatggttaag gaccataggt ttaggaaaac atttggaaaa ataagtttta   101580

gtcagctcgg gtctatatca ggaaacttgc gaagaccatt aatcaaaatg agactttgaa   101640

tcaagtatac attttattaa tatttcttct cttgtttaac atgataatac aaagatgata   101700

caaatggact ttattttgat ttgtgatacc cactaggtta tagaaatatt agagacttat   101760

gatttttgaa ggaaagaaag ttgtcacagc agctgttctc aacgaagtga gaaccgcatg   101820

agccactgca ccctgttaaa atggtttaac gcttgaacag attaaggaga ctaaagcagt   101880

aaaatggacc ctcagatctt caccaatatt cctattaaaa caaatataca caaacatgta   101940

tttcatagtg aaatatactt tttcattgac aactattaaa ccatttcagg gatttttagc   102000

aattatcaaa attgttcact atgattccca gacctccgac ctccagaatt ttctcctaaa   102060

tcagacttat tgagacacac aattttagcc tgctgtcttt acttacatct cagagaaatt   102120

gttttaggta tgaccaaaat gagggatgag taccttctct tcagttaggt cttacttcga   102180

tttttaaaac atgaggtaga tgatttgggc catgaaaaga cttacatcaa atgccaattc   102240

aatttccttt tttgtttcct ggataaaaca atgtttaaat ataatttaca atttacatgt   102300

ttcctgccct ctgtgaacat tttttttttt tacaatgtgg agttgacctg cacttctact   102360

tcagtgagaa aaaaaaataa ttaactcaga aataaaactt tgcttcaaga gaatagaaat   102420

tgtcctgacc ttttttgtaa tctcttctag ggcaaacata ataggcaatg aagccagcca   102480

atcataatgc cattattgca tgtgaatcag gttcaagggg caggtccttt tctgtgcttt   102540

aaaagtcaca ttaagcagta ttctagcacg cttcttggac agaatatttt attacaggaa   102600

ctttgtaagt attatgtgtt ccatttgtta gaacaagtga catttatctt ctggtaaagt   102660

gaacaaagat ctttagcaca atagaaaata gtcacaattg ttttgttcta cctgtttctc   102720

acaggtaata aagagtaatg atagatgaat gctaggagag ttttttgggt tcataaaaga   102780

gaacttgatt aaggcactac tgctacagaa atgaacttag aaatgatgta atgataatgg   102840

tgagggatca ttctctctgc tccccatggt aattcttcct gggtatggct gaccctctgc   102900

tgctgagtct gcaggggcta gtctagggat acagtgatga ggagtctacc ctcgcctctg   102960

tctctctcat gtggtcttat ccgtgtgtga aaaggtgcag aaatcttcgt tgctggtttg   103020

tattgtggcc tatattcgga aaagtgtact tattttattt tattttttat atttcctgtc   103080

tccctatttc tctaccccct ctccccaccc tgatataggt cctaaaccta tttctggcct   103140

tattattgag ctcatttagt tcagacaatc ttacagcaat tgaagaagac cctgatgcaa   103200

acaacctcca gattgcagtg actagaatta aaaagggaat aaattatgtg aaacaaacct   103260

tacgtgaatt tattctaaaa gcattttcca aaaagccaaa gatttccagg gagataagac   103320

aagcagaaga tctgaatact aagaaggaaa actatatttc taaccataca cttgctgaaa   103380

tgagcaaagg tcacaatttc ctcaaggaaa aagataaaat cagtggtttt ggaagcagcg   103440

tggacaaaca cttgatggaa gacagtgatg gtcaatcatt tattcacaat cccagcctca   103500

cagtgacagt gccaattgca cctggggaat ccgatttgga aaatatgaat gctgaggaac   103560

ttagcagtga ttcggatagt gaatacagca aagtggtaag aatgcttcat atactttgtg   103620

tttcatatta acaattagta tgaaatgaat gaaaatttca tatttctatt gtcataagtt   103680

cttcttaaca ttgcatgtag tgatggatag tttttgtgcg tgactttaca caacagcttc   103740

ctgaagattc atctggtaaa gttttcttac tagttcttaa taattgattt aatcttactt   103800

agctgtatga gaaagctcaa aggtatcttt gagccttccc atgcttcatc ccatgtttcc   103860

tgtcagttga aaagttacac agtctccctc cacagtgcct gtttgaatcc acctctcctt   103920

ttcatcacct ttcctttgta ctcactactt tttgcctaaa ccatttcaag cagagtctca   103980

actgatgcct ctgcttccat tttgcattta ctctagttta cttatttgat tattttcgct   104040

catgcagatt cagtcctaat catttcactc tcatgatgta tccatgatcc gcaaagtatc   104100

gctctctctc tctctctctt ctttttttta aaaaacggag acaggtctca ctctgttgcc   104160

cagtctggag tacagtggtg ctatcatagc ttactgcaac cttgaactcc tgggctcaag   104220

tgatcctcct gcctccacct cctgagttgc tgggactaca cacccatgcc acaacaccca   104280

gctaattttt ttaaaaaagt ttgtagagac aaggtttcac tatgtttccc aggctggtct   104340

caaactactg gactcaggca attcttcaaa ctttttcccc agttgctgag attacaggag   104400

tgagccacca cgcctggcca tccccaaagt ctcgaattat gtactgtgca caaagccttc   104460

acactatggc cctaaccagc tttgaccagc tctatctcct agtgctcacc catagatttt   104520

tacctgtacc aaaccaattt ccttttaggt cataaacact ctccacactt tgcttgggat   104580

ttccttctcc agtcaaaatc cttcaaggca tcacccttgt atttatcatc tattaaattg   104640

ttaatactta aatcgcagtt gggtcagggt taaatgaatt aacacgttaa tacatgtaaa   104700

atgtttagaa ccatactcaa tgttctcaaa atgttattta tttcatccct cctaatttct   104760

ccccaaatgg atgtagtccc ttctcatttt tgaaccgcaa acaattttat acttcttcct   104820

ggattcagta atcttaaatt ttaatttttt gagaaattat ggtatgcatc aaatagtact   104880

gtaaattcat tgagaacagg aactctttaa aacctttttt tgtgccctcc tctcccaccc   104940

ttacctgcat atttctagtg agtcaaggta tgtattgagt tttattttta ttgtgaaata   105000

taacaaccgt attacaaatt acttttatga gattgctttc aagtcttaag gcatcattta   105060

aaaataatct tttgttttct ctagctcatg ttagaaagta tttgacagat atttaccaaa   105120

tatcttctat ctccttaact tactaagact ccaccctcca tgaatttata gtggacttgg   105180

aaaacgagat tatatggaat aatcatgact gatatatata tatatatata tcagtaaaat   105240

gctcaggagg ctgaggcatg agaatcactt gagctccaga ggcggaggtt gcagtaagcc   105300

aagatcgcac cgctgcactc cagcttggac tacagagtga gactctgtct caaaaaaaat   105360

caatacataa gattaaatta aatacataag attaaattaa attaaaacaa aataaaataa   105420

aatgctctat atttaattga gtgaataaat gattaaataa ataaatcatg atatatgttt   105480

ctatgtagcc aaggacattt tttccaagac ggtaaagtaa ggaatcaaat ctagtcatcc   105540

ctcgatatct atgggcgagt agtttgaagg ccccccacag agactaaaat ctgcagatgc   105600

tcaattcctt tatataaaat ggcacaatgt ttaccataaa acctacacac atcctctcat   105660

atgtacactt taaattatct tcagattact tataatgtaa aagtaaatca ctgacacaat   105720

gtaaatattt gttttactat attttttatt tgtactattt ttattgttgt atttttatat   105780

ttattttttc caattatttt ccatctgtag ttggttgact ctacagatgt gggacccagg   105840

gatacagaag gccagctgta ttttatttgt atattttaaa atgttctaca tggaagaagt   105900

aatactccca aaattttaaa accgtgttca tttcagctta aagttagaaa atcagattcc   105960

acgtatgcct tttaaggagc aggcatctag gtttagtatc atatggaaag ggaaactaac   106020

tcagtcacct atttttttct aactaactct gtcacccatt taaagaagat taaaattata   106080

aactccaatt gcctggcaga cagttgctct cagaataaaa cttggattct aggtgttaaa   106140

gcacttcagg agctggggaa agtcaaccaa agacttctga aattatttct taacatttat   106200

gaggaattat ttcttacctg ttcatttttc tttcatttaa agtcaatggc tgacctttca   106260

tggatctcct tagctgctga caaaattctt attcttagta tgttgagttg caacattttt   106320

aagggaacct tatagaactt tccatttagc acttcatttt ctaactgaaa aagcagactc   106380

attaaaagga agtgatttta ttcacagtta taaagctaga gttatacagt tataaatcta   106440

gagttataga gttatacagt tataaaggca gagccatgtc aagagtccta ggcttgtgac   106500

ttatagctca atggaatttc tacctctctt gtcctctctt tgtccatttg aaacacaaaa   106560

caaacattcc tattggactt aataatttgt ctcccctggg gtataaagcc atgcagctat   106620

agaatttata tatctgtggc atgcagatga aggtgtgttg tcataatggt tagctatctt   106680

ttataactag tgattttatt tgtattttat aactgaaata gattatttta accattcata   106740

aaattactct gtcacttatt ccatgagccc ttccgaaagc gtatgaaatc tagtgcccta   106800

taaactgagt tgtctaaaaa tcatttgatg ttaatattct aatattcttg attttcacta   106860

atttttttct cattacataa tggttatatc tatatgataa aagagtgtac attcttactc   106920

tattacattt ccatggtatg cacaattaaa tatacaggag tttgtggcta ccttagaggt   106980

tgtagtaaca gatacacaag ctagtatttt taagtcatgt agcatagtgt ttgaattagc   107040

aagccatttt aaaaaaagtg tttgttgtca tcgatttctg catcattatt attacttaag   107100

aactcaggtt cttagtgcta ctgacttcta attatgaact ttgaaagttt acccttcttc   107160

ataaaaaatt ttccatgacg tatctcaaag tatgtcatat taagtataga caaacctacc   107220

tgaaaatata agaattgaga aataatgaag gttcaagatc tagaggaaat ttgtttgata   107280

agatattaag ctgtggtcaa ctataaaaac cttacatcta aggtctttct ttccagcctc   107340

ttcagattaa aatgtttcca gtttaaattc tgtcattttt gttttgtttt gttttcccat   107400

tcagatcact aaaatagtgt acattttatt tatttgtcta aaatgtcttt aatcctccta   107460

tgctaacttt tcctgctcta attctcataa tcttcatctc ccacttgagt tcccagagtc   107520

ttgaactgtg aattccctct tttgcaactt ttattttttt cgtatctgag atgcctttga   107580

aatagtgatg gttgtgtttg tgatgagcct ggatgagcca aagaggcaaa ttgaattacc   107640

caatagaaag taactcctaa tttatatatt tatgtcatta agtcttagcc actaccttgg   107700

gatatagtta agaatgccac tttttaagat agaatatttg cctcaaatct tagcttttga   107760

taagaccttg agcaatttac aaaaacattt ttttcagttt atttatgtgt aaaatagatt   107820

gtaataaaga ttatatgatt ctcataaata attagacaaa tgcttattga aaagtgctca   107880

atgtacaatt attataagta tggaattgag tgcttatata cacactgtaa gtagctattg   107940

gttacagatt gaatttaaaa gagatagcgt gatgaagatc agtgcttcag aattttagtg   108000

tgtgaaagac atacttgggg actttattac aaatgcctgt tctggatcat atcctttgaa   108060

ttgtttgcct aaatttggat gcaacttcag aatcattaac aacgtttgca gcagctactg   108120

atcaatagag actactatga acaatcatac tccaacaaat tggaaaacct aatggaaatt   108180

gataaattac tcaacacata caacttgcca agactgtatc atgaagaaat ggaaaactca   108240

aacagaccaa taatgagtaa caagattgaa tcagtaataa aatctctcct agcaaagaaa   108300

agtccaggac cacatggctt cactgatgaa ttctaccaaa catttaaaga agaactaata   108360

ctaattcttc ttaaattatt ccaaaaaaat caaaaggaaa ggaattcttc taaattcatt   108420

ctacaaggcc aatattaccc caataccaga acaagacagg gacacacaca cacgaaaaga   108480

aagctgaagg ccactatccc tgatgaacac agatgcaaaa tgccccaaca aaatactagc   108540

aactcaaatc caacagccta tcaaaaagat tattcaccat gctcaactgg aaatcgtccc   108600

agggatgcaa agatgtttca acatttgcag aacaataaac tttctatatt atatcaacag   108660

aatgaaacat aaaaaccata taatcatctc aatagacaga gaaaaagcat tttataaaat   108720

ccagtatcct ttatttgata aaaattatca acaaattaag tatagaagaa acatacctta   108780

atgtaatgaa ggccatatgt aacaaaccca cagctaacat gatactaacc agggaagagc   108840

tgaaagcttt ctctccaaga tctggaacaa gataaggatg cccactttca ctacttttat   108900

tcaacatagt aatgaagttc tagccagagc aatcaggcaa gagaaagaaa taaaggacat   108960

ttaaattgga aagaaggaag tcaaattctc tttgttttta tatgatctga tcttagatat   109020

agagagttct aatgacccca tgaaaaaaag tagtagattt cataaatgaa ttcagtaatg   109080

ttggaggaca caaaatcaac atgcaaaaat caatattatt tctatatgtt aacaacaaat   109140

aatctgaaaa taagaaagca atcccattta caatagctac aaaaaataaa atacctagaa   109200

ataaatttaa acaaggaggt gaaatatatt tacaatgaaa actataaaat attggtgaga   109260

gaaattgaag aggacacaaa aagggaaaga tattccatgt tcatggatta gaataattat   109320

tatttttaaa atgtccatat tacccaaagc aatctacagg tttaatgcaa tccctatcaa   109380

aataccagtg acattcttta cagaaaaaaa aaaaaaaagt cctaacattt gtatgaaacc   109440

acaaaagacc ctaaatagcc caagtaacct ggaacaaaaa gaacaaagct gatggcttca   109500

cactaactga cttcaaaaca tactataaag ctatagtaac caaacagaat gatactgaca   109560

taaaacagac acacagagca atacataaga atagagagcc cagaaataaa tctacacata   109620

tacagtcaac tgagttttga caaggttcca agtacctata atagagaaag gacagcctct   109680

ttagtaaatg gttctgggca aactgaatag ccacatgcaa aagaatgaaa ttagaccttt   109740

atctcttact ttatacacaa gtcaactcaa aatagactac ttaaatgtaa gactgaaaac   109800

tacacaacta ttagagaaga aaaaaaacag ggggaaagct tcatgatgtt gttctaggca   109860

aggatttttt tggataaaac ctaaaaagca caggcaacaa aagcaaatat agacaaattg   109920

gattatatta aactaaaaag cttctgcaca gcaaggcaaa caatcaatag agtgaagaga   109980

taacctacag aatgggaaaa taaatttgta aactatgcat ctgataatgg gttaatatct   110040

aaaacataca aggaactcaa acaactcaac aacgacaaaa aaaacaaata attcaaaaat   110100

ggacaaaaga cctgaataga tatttctcaa aagaagacaa agaaatgcca acagataaat   110160

gaaaatatgc tcaacatcac taatcaccag ggaaatgcaa atcaaaccta tcttgaggta   110220

tctcctcacc ctagttaaaa tggctaccat caaaaaatca aaagatataa gtgtttaaag   110280

gatatggaga aaagggaatc cttacacact gattgtgaga atgtaaatta gtaccaccat   110340

tatggaaagt aatatggggg ttctttaaaa aattaaaaat agaattttca tatgatccag   110400

cagtcccaat actaagtaaa tatccagatg aaatgaaatc agtatgttga agagatacag   110460

taaacataga atactgtact cctatatgtt tattgctgca ctgttcacaa tagccaagtt   110520

atcatattaa cctaaatgat cgtaaataaa taaatgcata aagaaaatgt acataagaaa   110580

aattgaacgc cattcagcca taagaaataa tgaaatcctg ttatttgtgg caacatgaat   110640

gaacctggag gacattatgt taagtgaaat cagccaggca cagaaagtca aatatctcac   110700

acatatgtgg aatctaaagg gttgtcatag aagtagatag tagaatagtg gttatcggag   110760

gatgggaggc ttggaggagc gaggtgtggg gaaagattgg tcaacaggta caaagctaca   110820

gtgagataga aagaataagt tctggtgttc tattgaatcg ttggatgact agagttaacc   110880

ataatgtgtt gtatatttca aaatagctag aagtttttaa atggtctcct cacaaagaaa   110940

tggtaaatgt tcaaagctat ggatctgcta gttaccctat ttgataatta tataatgtat   111000

acatgtatca aactatcaca tgtaccccat aaatatgtac aattattatg tgtcaataat   111060

ttttaaaata aatgatgcca acttaatccc tagcttactt ggattcaggt ttctgagata   111120

ttattttctt tattcagggg ctatgggtat atttcccctt ttgcttgttt aagaacctgc   111180

attttgagca aggggaaaaa acatcactga cctttgatat ctctccctct cttctcccta   111240

cccaaaaacc ctctctttta tgacctagca tcctggtttc tcaacagagt ttatggagaa   111300

ttttcagtgc tctcctagta taagttttca ggttgacaga tttcctcaac ctgatagaca   111360

gttaaaaata cactccagaa tcaaatcaaa atattttaca gtaaaacctc ttatcagaaa   111420

ataaccaaag agatgagtta aaacaaacgg tttagtcaaa tatcttaaac agttctgagg   111480

aaacaaatgg aaatagaaca atagcacttc tctgaagaga tagtcagtgt cagaatcaag   111540

aaagacatgc tgttatctca aaggtaccca tgagaataat actcttttca ctgtttctaa   111600

gaatgcaggc actgaactga tggctcttct cagagtcagc cttctcctga agtgcaatga   111660

agccctccaa gcacactcca aacattaaca acacactaca caggcttttt taccactggc   111720

agtgaagtgc ttcctcatta gaagccttaa aggaagtatg aaatgcaccc atttgtcaat   111780

aaatatttat tacaccttac tatgctctaa gcactgtgct aagaattgct gagggaaaaa   111840

agatcatgtt ctcacacagc tgcaacaatt taatatcggg attaacttga aagttaaaat   111900

ataagggctc agggtctaga tatataagat tgtgagctga tccaaggatg tattagtttc   111960

ttacggctgt tgtaacaaat tagcaaaact cagtggctta caacaacaga aatttattct   112020

tttgccagtt ctggaggcta gaagtctgaa atcaaggtct gagcaaggcc atgatttctc   112080

taaaggctct agtaagtatc ctgccttgct gctttctaac tttggaggtt gttggcaatc   112140

cttgcagctt gcagctgcat catcccaatc tctggcccgg tactcacgta gttttctccc   112200

tgtgtgtctc ggtcttttct tcttataagg accccagtta tattggattt ggacccacac   112260

aatgacctca tcttcattgt gtctgcaaag accatatttc caaataagat cacactcaaa   112320

catgccaggg ttaggacttc aacataactt ttggaggatt acaattcaac ccacaacaaa   112380

gaattttgac ttagaagact agatggttat tgatacaatt aagaatacac tgatggagga   112440

gaaaattgag gaggtagggg aaatacagag tttaatttgg tggcatcata aatttgaact   112500

acttgcagta caggcagtga acctgaacag gaggtatatg gaaagataaa tcttaaggaa   112560

agaagaaaag tcagagttgt agataggttg ggattttgta tgctaacttt cattaatcac   112620

gggattgtgt aggggtcagt tccctgggaa accaatcctg agagagaaat ctgagattta   112680

ctgagaagtg ttttcaggaa cgaaacgtaa catctgtaaa aagtgaggca tgcaaaatta   112740

ttgggcagag agagaagttg aactgttaaa attgcaacag agatttcggc tgatcctatt   112800

ggcatctctg atgctgtgac aaccctctgg agtagttcca aaacaaagca agagggtcag   112860

gcctttcttc tccacaccat tcattggatg caggctctcc ctttaccttt ccaggggaga   112920

agggtataac cttgggggaa gcacctccct tctgccacga taaggcccaa agagggattc   112980

agatgtgagc cttcagcatc caacactttt ggcagctggg ggaatgagca gcttgctgga   113040

aagcaggatg tggacagtgc cttagagcat ctacttcatg acagaaccac agacagcagc   113100

tgagaacagc ggatcaaaca catttgagag gtggatgcaa aagaagaaag cacgcacaca   113160

cacacggata aaatgtatac agtagcccct ttacacacat tatataattt tcgtctttgt   113220

gacctcctta ggaagtaaat ataatgcatc tatatttgca gatgactgcg attctaaaag   113280

attaagaaaa gatttggtta gtcatggacg tatctggggg tctttttaaa tttaaacccc   113340

aagctgtaat cattatacta catgccatag aaaggcaaga aaatgagtag tagtataatt   113400

gttttctgct atacctctgt aatggtgtaa ttcagggtga aattttctgt tgtaatggta   113460

ttgtacattt gctgattcat tgggattctg atattgtgct tctaatccac cttaatgctg   113520

actgattagg ttatagtcta ccttggtaat aatgtgtgat ttttatattt taggtgttta   113580

aatttgtttc ttcaaaacta tcttattccc ttctttattg aaaagtaaaa ctgattttac   113640

ttctagaata tatttctttc tcaagactac ataacccttt cctttccatt tattcagtat   113700

taaatgcata ttttatacat tatggtattt catgtgtatc tgtatattta tttttgcata   113760

tattaatgtg tctatttttt catgcaaatt attgataaat atgacaaact catctagacc   113820

aaattcaagt tcttgtagct tctgcctgat acattcattc ttctctaggt gaaaaccttg   113880

ctgaggtaac tatgaggttc ttagtgctac taagacttat ccagctctcc ctggcttgtt   113940

gatgaaattg gcaagtgact cagaaatatc actaaagtcc agatcattgc ctttaaagca   114000

tctcctttgt catgacttat tatgttatta cagaaaagta ttaaatcaat ttggcataat   114060

tttttctaca catcactttg ctctctttga acctttgtgt tctctcagga caatgtatta   114120

agtagaattg atttattatt atattatctt tcacattaag gctatattag gggctaggga   114180

gtacacttac tgccacacca aggtacacat gttaagatct taactatttg aataaaccta   114240

ttttacttaa gggtacatgg gtaatcccta tttttttgtg tgtgtgtttt gttatttttg   114300

gctatttctg agtcaggact ctgtttaact gcatgcaaca gagacttaac tacattggca   114360

taactggata gaacattctg ttttcatatt ttaaaacatc cacagatcag cagtccacgt   114420

ggcctccatg tcctaggctc catctcttct cccttctgcc aatcttcaca tgtgtttttt   114480

cttctatatt aatgcctatg attagaggtg actgttccac ctacagcttt atatccaata   114540

cccaggtaga gaaagaaata gaacgaagca gaagtaatga ctatcccact tgcctgagga   114600

agggcaaaac tttcccagag atccttatcc aactttggct tatgtcttat tggcaagaac   114660

agtgtgacat ggccacccct aacaacaagg tagcctggct gaggcaggac atttatctgg   114720

gcatattgct accctgaata aaatctggat tctcttggta agataccttg gaaggtatta   114780

acaaggtcag gcatgcttct ccaatattac tactgctact aattattatt attcctttat   114840

gaaaatgtca aaagaattga aggatggtaa ttttctattt taagagatgc agttactagg   114900

cataatttgg aataatatgc atcaattgta atgttatact ttgaaacata ttgtataaaa   114960

ttaccaaaaa acaaaagtta atttttactt attgaattag aaaatatata tgaaaataag   115020

aatattttaa gttaaataat aaaaaactaa atatccaacc atttttaatc tgcaaaaact   115080

agaaatttca tgtggctcaa cataatacaa aggcataagt aaaatataaa cttcattcta   115140

cctgtataat cttatttctt aattacataa atattatgtt actgaacaca gatattttat   115200

tcatttcttt tatttgtgca tagtagagaa cacattaaaa ttttctatga ctctctgccc   115260

agaattataa taggcataga gtttttctct cctaaattac actcatgaaa tatttttggc   115320

cccctataaa tattgagtcc cccaaaaacc acactaaaaa cttcatgtac ttcaaaggta   115380

aagggtgatt gatcattgac aacaaaaagt atacactcta atagcttgca ccttaggtaa   115440

atatacaaaa aattataaca cagaacaaag caaagcacaa tccgtaacag gacactaaac   115500

tagtccattg aggatgcatt gagtaagggg ctgtatctgg ctgacttcac atgaaaggag   115560

gtggcactta gaccagacct tacagtatgg agaaaatttc actgggcaga tgtggtacag   115620

aaggaaatct caggcagagg aacaagcatt catattgttc acctgattca ctcattcatt   115680

catctatcca cccattcatc tattcagtgt tcagtttaca aagtcattat ctttggagat   115740

acttaaatat gcttattatt atgaaatgta gtcattttgt tgacctgata aaaagttgtt   115800

tcaatatttg cagttcccaa attaaatatt taatgtcctt ttactatgtg gtggttttaa   115860

ttacactgtt atcaagactt tctctcttta gatttttaat caaagtttta gatttacctt   115920

ctgcttatta ctacacttta gaaaatataa taatctttta aaaatgcatt tgactttgaa   115980

agatttaggg attagttaca gttatgctgt ttcgtaaaat tggcatttga ttctatattt   116040

tatgcataga ttttttttaa aagcactctt ctgtagaatt gcacttagac catttgtttt   116100

tttcaggttg tttccaaaga atttgaaaaa tctttccatc ttcattggat ttgtttacgt   116160

gcctaaaaac aatgaaatat ttgtctgaca tattcaaatc aatgtgtctt attctttata   116220

ttttgataaa tttggaaact tcactttttt gcaatgctgt ttaaaatgtc aaaattaatt   116280

aaataaaaat aagtcaatca agaaatgcta attttagaat atgcttttta aagctgcata   116340

ctcttactgc cacctcaccc cctatactga gaatcactta tatttaaatg ttgcttgcat   116400

ttaaggaaaa atagaatgca aaacattgca ttagcacatt atagtattta aattcaattt   116460

ttaaatagta gagtagaatt atgtaactgt ttaattgatt gtttttaagt ctctgttgaa   116520

tgacatttaa tcttagtact gtgattcaaa tatattgctt aacgttgagt atatagcatg   116580

tactttcaaa tatgtaacta atttctactt acaggtatat gactttaaac attttaaaac   116640

acagttgact aaactctttc atcatgctgc atttctaaaa ttcagtacct aaccttcttc   116700

tcacaggggt aatatcaaac tggatcagtc aaggatgcag ctctgtgctt ttaaccaggc   116760

agagacatat gtcaccactt ttacacaggt tacctaaaaa aatcatacat acgatatttt   116820

ttcaatgtct tgcatgctgt tcagctacaa aacctttctg cctgacccac tgcaagaaag   116880

tagaaacata tacagttgtt caatagataa agtgacatca cagcatgtca ccagggcaat   116940

ttgattattt ttttgtgatt ctcttgatga cttcttgatg taaccttcat gtgcttaagt   117000

gatttcaagt gcatgatctg tagattttta ttgaattgat tataaaagta aaatgcagaa   117060

tgtaacagta gccattgaag ctacatttaa tttgaaaacc tctatcaact tcccttcctg   117120

atttaatcta cataaaaata tggagagatg tatatcacat taaattgtca catttaaatt   117180

aagtagatca aaactctaaa aaattgtgga agaagtgttt ctggcataaa tataaaatct   117240

cagagcagga aaagatcatt gtaattctag ctttgtattt aataattctg gttatgtatt   117300

tatggataag caaattgaga ctcatgcttt cttagtacac atctagaaag ttggggtcaa   117360

agccaaagta ccctgcttct agtataaact ttgaatacat tttgaaatgg ttttatgcac   117420

tgttagttat gggactttat ttttttaaat caactcagta attaacattt gattttattt   117480

gctcctatat aaaatgcatc agttaaaagt tgataggcct tgcctatgaa tgaataagtg   117540

ataagtgttc aaaatgttta attttattcc agaagtaata ttactcattg ataagaataa   117600

gtttctgatt atatacataa tcagatcagt ctctagaaac taagaggttt agatagagca   117660

tattataaat cctatctatc aataacacat agaacacttt tactgaaatt agatacagat   117720

taatatgtat tgccttattg aatatttcta aaatgtatta aaatacatac taagatatat   117780

tttaatttta gcatactttg ttgaatgact gaactttaat agttctagga tgggggcagg   117840

aatctctgcc aataagaatc ttgactcctt tttataatct agttcatatt ttgaatttct   117900

ctgtcattgt tgagatgttt gtattattgt tatctattgt gcaatgatga aagcaaaact   117960

ttatcctgaa attgacacac cttagagata atattgctaa cagtttcaaa tgaaaaatta   118020

gttattttag tgttccagtt tatttgaaga taattttaaa ggtggcctaa gtaaaagata   118080

tatttttcta tttcaaattt ggtggggatt tagaggcaat attctcatag aaaactattt   118140

tattccagaa tatggtgaat tttcttcaac tagagcctaa ataaggatgc atatacaccc   118200

aatattatct atataggtat agataaaaca tataattttt gagaaagcta tttctagaaa   118260

tatatataca tgcatagaca tataaacata tgcatatata tgttttgaat tcataaattc   118320

ttattacttt tttaccaagc tgttagaaaa gatgaggtac atgttaatga atggtcatcc   118380

tcttaagaaa aaaactgaat attcagttaa gaatgacttg aaatatggca ctttagcaaa   118440

agctgcctac ataaaggata tagttatttt atccatgtaa aatttctatt tatattttca   118500

atattagaaa tccacatgtt taaaaagcta gtaattattc cattcattaa aattcacttt   118560

tccttgccct ccttcattgt gggtagtatt agtagttaac agaaatgatt cagatatcta   118620

ggtagcttac tttgtgtttg tcattcttgt ttgtttcaaa attatagata atatttacga   118680

agcttgagtc tgcgtatcta cactttgcct ttatgtttgc taaggttcca atccttcttt   118740

acctacttgt tgcatttttt taagctggca taaatagcaa aattgtttaa atgtttgctt   118800

ctaaagactt taagacactc tgacttgacc cactgtattc cagctgcttt ctctgcaaac   118860

agtgtagcag ttctgtgaca gagcacagag agagcccttg aatatcaatg gccactttac   118920

actcctagct ctttgcttct cttcttttca ttagaaagat gcttcaagat gatactatag   118980

gacctggctg agaaatctgt agccagtcta gccttcttac atggccaact gttgttgctt   119040

ttatatgatt tctttatatt catatcttat catttagtca cgtaagtttt catgttattg   119100

gatagaaagt gccctaggta gaagattctg agaaaaagaa gaggtctccg tgaaatcact   119160

ggttttattc tgaatttctc tggtggtggc tgagatttga cctcattatt tcaccaacag   119220

aatactatat atcatgttga ccttgtgatg gaactgtgtg tttcacgctg aataagtagc   119280

tattcctccc agagcctaca caatatttct ctgctagcaa tagacaaaga aaaataggaa   119340

aggaaaaaaa attggttttc ttgccctttt tttaaaaaaa gagctaaagt tttagttgcc   119400

cataattaga atgtgagccc agaatttatt gcaactagtt aataaactga caattttctg   119460

ctaaattagt ggaagtaaca ttaaaactta gacaacagaa gaaaatacag ttgagttttc   119520

cactgatcaa taatatctgg agtatttttt aattatttcc atttttttcc tgaaattcct   119580

gagcttcagt gattttttaa cttgaggcat taccttttaa aaagaatctt gagaaatttc   119640

atatcaaaaa aaaaagattg tagagacctc aaggggccca gaaatctaaa tcatgttaag   119700

aaatgtgatt acactcaaga tgaaaagcac taatagtaat atcaataata ttaatgacct   119760

ccaattttaa aaactctata agaggataat gttcacattt ctccagaagg aaaaaaataa   119820

aggccctgaa tgattgcaag agagaagaaa ggttattttt gttctacacc agaagagagt   119880

atttaaacat ctagttgtcc tgtaacataa tgggaaactt ggaaaatatt ggactcttat   119940

gccacatagt aactatgtgt ggatttcttc tcaaaggatc ctttgatcct ttaattgaaa   120000

tttactattt tactccttaa tgattcaaga acacaattat agatattgac cgtaaaacta   120060

cacaattaaa ttaaaagatg gataatagta acttgaaact aattttaaaa tgtctttctt   120120

gcttattaac agataatgga gcttagttta ccactgtctg ccataatttt tcttctcttt   120180

tatacccatc tcctcctttt gatttgcttc tctcaacttt cttactgtct tttgtgagta   120240

ttttaaggct caggtgaaat aaccattcta ggctctgctc cttaaagaat atcttttttt   120300

ttgttgtgtg aagcaaacag tttatagtat gtacttgaaa tgtaacattt ttcagttctt   120360

ttcagcatca atcattctct ttgagtaagg tttttgttga gttctgtgtt ttgtacagtg   120420

ctgctgtgtt tgatagtttc ttcttttgag cgttagatta tcaagtcatt agacactcct   120480

acctcacacc tcttggaaca ataaataact agcattaacc atcatccatg atagcatgaa   120540

ataggcttac atcgttaatg tttatcttag gaaatgccag tgataaattt gtaagtgaac   120600

aacttaggac atgttctaat atgatacata tatttaacac aatttctact caagcagtat   120660

agtagaaaac acagcttcaa ggcaatcaaa gggaaaacca tgaagaataa taaagctttt   120720

aatttggaca tattttcagt aattgaaaag gagcatctta aatagctaca taagtttaca   120780

atcaagataa ggattgtttc acagctatag tgttgtatgg atgcacactg aaaaatatgg   120840

aaagatatgt ctctctctct ctctctctct ctctcctctc tctctttttc tctctctcga   120900

ttacctcaag ggggttgaat caaggagata gtggagggaa cttttatttt gcactgtaaa   120960

tactattata catttaaaat gtttgagtca actatatcac tttcatattt ttaaaacact   121020

tttagaaggc acagtcaata tcatattatt caataaaaag gcaggaatgc taattatggt   121080

acacttctga ttcctaatac tagtgagtcc accttcttga tcctatgctt atatttatat   121140

ttactttatt tataactaga ctgccaatga tgaaaaaaat tgatacttcc cttttattag   121200

aaatcaaatc catgtgaaaa ttacagaagg tcctatttat aatagcaaaa gaaatttctt   121260

tcatactaaa gcatttattt cacttctcta atatagtcat tctttcattt ccaaaattac   121320

atggaaaact aaacaacaga tgattgagtt taaagaaatg aagataatat agaaattaat   121380

catataaaat aatacaaata attgatatga tcttccttgt atagtaaaaa acatatattc   121440

aaagtactta aatatggtga tgcctactgt gagaattcaa tatatttcac cgcaggaaaa   121500

aaaaacttta ttatatatat cagcctttct atataaaggt attctcttag aaatctgcta   121560

aagaagctta tactgtagca agtatagatt tcaaaggctg aattgactag aactgtctat   121620

attgctaaag catgcttata aacatttaat tttatataca gtatggaaat agttactgtt   121680

tgaatactta atgcattccc aagaaaacat tgaatgtcta agaatctatt agccataata   121740

atttgtctgt aaatacaaat taattaataa tagttcatgt taaatatttt gataatttct   121800

gtcccattga acaataatat tgaataactt tatgatgtaa aattctgtgc caagctgaat   121860

tcaattgacc attaaaaaaa cataaaacct gcatatgaaa aaaagtttca acaacaagat   121920

acactatata aaatcacgtg aatttttact tgctcataat ctaatttggc ataaatcttt   121980

gttaatgctc tcttaaacag tgagaaaacc aattattgat gtttgaagat gctttcatga   122040

atttagctaa agtcagaatt ctgcaaataa gaatcatttt atttaaaagt tgttaccagc   122100

tcagagaaaa accattataa ctatttccta ttgttaatat tgtgtctaat agcagggggg   122160

tgctttgtat tctttctatc agcaattcct ctcactgctt tacctcaaaa cccaggccaa   122220

taattctttt ttcagaaatg aagggcctgg tcttaacttc acagaataat agggccttgt   122280

ctttcacttc tctggtgata gttcacgtgc agccgagagg tcaggaattg aagccattaa   122340

aactgtagtc ttctaaatat ggtactttgg attttgtggc aattggcaca aaatacatat   122400

tagtaattat aagtttatcc aacatcgttt cctggattaa tctgtatttt aaaacttata   122460

tattttaaaa ctcattctat agtttatact ttaaagccta ttctatagtt ttatagaata   122520

ttcagttata attaatttct attatcttat tttaaattaa actaatttag atgaattcaa   122580

tcagtttaaa taacatgttt ttgagtgaaa ttttgtactg atactttcat aactgaaact   122640

gttatcaaac tcctggacct ggtgggaata atgcctctag gccaacatag attggaggag   122700

ttctcttaat aggttgttca taattattta ctccagttat aagaaagaca ttgtctgctt   122760

acatcattcc ttatgtacaa tactttatcc atgccatttt tatgatgttg tatactaggt   122820

gataataata gcattgagaa tttaatgtgg tacccatcaa gaatacttct agcttccaag   122880

tcaatctcta aaagtcaaac ctttagattg ggctatcata ttaatacaaa ttcatagatt   122940

gagaatcaat ttatctgaaa taagtatttt attattttta gcacttgcac ttgcttgaac   123000

tactctaaaa aagataaagt tgtaacttaa taagagaatt gtgttgtagt aactagtagc   123060

tttcaatatt cacatgtcat ttagcaaatg agaatgaaaa attaactctt ccattgatat   123120

gctgctttac tcctttataa aacaatattt gggaaatttg acagagtttt gctacagttg   123180

ctgtatgtat tttttgtaaa gatttcttcg tgtgtgtgtg tgtatgtgta aacatcatgg   123240

ttactcataa agctctgggt gagaaaaacc tatttgcgtt atgatcactt atatgatcat   123300

aatgacaatg aattcattat tccatgtgta agtctgccat gtttaatttt cttcgatctt   123360

tgtttcagag tttgcatgtg gtgcttactt tagtagccac tttcttgaca ttataaataa   123420

tactgtttga tcttttctac tatatactaa aatgttatat acaaaatggg tggtgttggt   123480

atggtcattg gcattttgat ttcaaaaccg tatttgattt tgtggtcttg atcaaagaac   123540

ttctatctat atcatcctgc tacatatatt taaattcaag agataataaa aaatacattt   123600

ggactttatc ttgcacttat ctttttaaaa aattttaact atcaataagt tttttgccaa   123660

ctatttgatc tgagctttca atgatcaggc attagtaatt tgacacttgt attatattgc   123720

aaatagggta taggttgtcc tcaaataatg attgtcagtg tccataaatt tatattaaaa   123780

atttaaaaaa taagatgtgg tcaatacttt ccaaaagtga tagttaacat caatatatta   123840

ccttatctaa ttttggccac gtacttgtta gtataataaa cataataaag tttattattt   123900

tacaggatgg tgtagataga aagatcaagt atagatacat ttaaggttac ttgacctcaa   123960

tatgtgttta tacatttttt atggccatca tactattaat cttttttcat aatactttgc   124020

atgagtctga ttattaaata aggcttaaat atcatatttg aatgaactct aaatgaacta   124080

cctggtgggg tggtgaattc ctttctagag attaaaccgg tcaagctcct cagagtgcag   124140

cacagttgat aaccctttgc ctggagaagg agaagaagca gaggctgaac ctatgaattc   124200

cgatgagcca gaggcctgtt tcacagatgg taagacaaaa attgagacct tggttagcat   124260

tccttaatta gtgttctggg gtttgtctta acgcctaata cttaccagag gttgtcggta   124320

agtcagaaga ctccattcca tgctgattca gctatagctg tatgatgatt aagggcaagt   124380

cactagagct ctctaagctt gagtttccac atctatggca cttgactaac agtaatttcc   124440

tatcactgta tgttagactg taagcatgct actacttctt attttagagc cttaattcgt   124500

attcccagat caatggaacc accagaatac aagttaatga aagagtctgt actctggtcc   124560

ttttaatcaa aaatggaatc tactcactaa ctctcagaaa actgtttgat actgttgact   124620

acagtctctc tcaaaattct tcctttcctt agtttcagag gccatagtct acctttggtc   124680

ttttatttgt cttagagttc tgagttcctc tctctatttc tttaatgagt attttttctg   124740

cacatcctgt aaataatgat ttctccccac atgttcaatc ttcagttatc ttttcttatt   124800

ctgaagctct gaggtgtttc atgcatgcct gtggcttgaa aagccatttc tgtgctattg   124860

actcttaaca tcaatgtctt tacctctaac ctcactcttg agtcccagat ctgcttacaa   124920

ttccccattg gtcatcacca tctgttgttt gtaaaacatt ccaagtttaa taagtttttt   124980

tttttttgaa aagcaaaaac aaaaacaaaa ctttagtatg gtttacagct tcctccagtc   125040

tttattagta acttcatgat ctaccttacc ctcaagctaa agactttgag agacccttaa   125100

agttttcctt gctagtcaca agttcatcag gaactctgga gatagggccc aagcccttaa   125160

gaggatttgc atgcacacta aaatgtgaga atccttggcc tctagggtaa agtctgaagt   125220

ccttaacttg acatgtaaag ttctttacat ttggccttag tctcttgttt tgtaacagta   125280

cctccttcta ctcctgtatg ctttctgata tgctgaattt cttactactt ctggaatttg   125340

tcagggataa tgcagtattg tctgaacaag tattgtatca tctaggtaaa aatacaagcc   125400

cagagtaggg ctgcaatgta atacagtaat acaaagttca aactttggag cctgataaac   125460

atatgttcta atttgccgac ttatctgcct gtgagaactt gtgcacaatt taaaatcttg   125520

ttcttcagat atctcatctg taaaatgggg atatcagcat ccacatcaca gcgatgctaa   125580

gaggatcaaa taagataatg attataaact tactagcaca gtgcctatct tccttcttct   125640

acttttctta ttcttcaagg attctgttaa caatcttata cagaagttat gatagcacag   125700

atgctaatga cttatctagt catgggctta ccctcagcat tagtattttt tgaaaaatca   125760

tcgacttgct ttcagtgtcc aagattttct caactggttt cttataacat tcatgggtta   125820

agcaaaatga ttggaaaata aagacatcag caaactacaa agagtgcatg gattttcttt   125880

aaatacacac caaatatcat tttatgtaag aagcaaaggt gtacgacatc cagtcaatat   125940

aaattttgtg cttgctgaaa ttagtgctat aagcaaatgc acagtttcct ttaaaagtgt   126000

ccatgttaca gagatttaag aatttcatca acatgtatgg cctgctcctc aagaaattta   126060

ttagcagtat atagacttaa atttgtattg atgctaccaa gattttccct attcatttta   126120

tgaatgatca tgacttaaaa ttctaggata actagaaaga agttgggctt atcaatcaac   126180

ttaaagtttc aaaccaaaaa atgacttcaa aaaacttaaa ctcttacaga aagtattaat   126240

actatgctat ttcagactgt aggtgctgtt ataataagat ataatacaaa gtttttttaa   126300

tcctataaac atcaatgaaa atacttttgt gaatactctg agattattca ttgcttccaa   126360

actgaggcca gtatagaaga aatattatgg aaacacattt tccaatgaac ctgggcttgg   126420

accattgaaa tttactgagg gagcatatat ctctgagtca catccctttt atgtgctcca   126480

gcagagactt catacagtct ctggatctgt agcctaataa attcagtgaa gcagccaatt   126540

tgcttagcct ttcaaccgtg tattcacata atcattcttt attccagtaa acaaataatt   126600

attaaatacc tgtgtgccag gtccagttcc aggcactgga gggagatgga gctgtgaaca   126660

aaacaatacc ccttgctgaa gaaacatatc aagatgtagc aggtcagata agtgaaaagt   126720

gctatggaga aggtatatgg aaaagaggaa taccaagagt gagggggaag aacttactag   126780

cacataaata tgctatcaat gaatgattgg tcagagaaag cctgcctata aaggtggcgt   126840

ttcttccgtg atgtaaagaa aattgaaggg ggccgtgcaa atatatggag ggaaagtatt   126900

ttaggcagag taatgaaggc acatgcccca aggtgaggat atgcataaca tttgggaaaa   126960

accaagaggc caaaatagat ggagaataat gaaagatggg aagaggatta aaagttaagg   127020

tcagaggctg ggtgaagtgg ctcacaccta taattccagt actttgggag gccgaggtgg   127080

gcgatcactt gaggccagga gttcaagacc agcctggcca acgtagcgaa accccatttt   127140

tactgaaaat gaaaaaaaaa ttaattgatc ttggtgatac atgcctataa tcccagctac   127200

ttgtgaggct gaggcacgag aattacttga atccaggagg cagaggttgc agtgagccaa   127260

gattgtgcca ctgcactcca gcctggacga cagaggaaga ctctgtctcc aacaaacaaa   127320

caaataaaac aaatgacatt atttttaaaa agtgtagatc agagatgtag tagaggccag   127380

attataagac atttgaagaa cattataagg atgtgatttt aaaatctcac aatgtgcaat   127440

cttaagagtg gaagggcgaa tagcaatggc agaagctgga agatttcttg gagtttctgc   127500

ataaatccag gtgagaggtg atgggagctt agactagtat ggtagagttt tgtatagtga   127560

gggtgtgaca tgctgagtat attttgaagt tagagctgaa gggatttgtt gatggattga   127620

acattgggtg cttaaaaact ggaaatgcat agtttccaca tgaagactga gaagcatggg   127680

cttgtcagaa tgaagaatca tgaacatgtt tacttacaag ttggtaattg gtctacaaga   127740

gctgggctag aatcaatgcc agttcagagc aatgtttcac ctccagagat ctctgctacc   127800

tgaaaggtaa cagaaaaaat taaatgaagt atgaaaaaga attaaatcca agtagcatgt   127860

ttttactgaa gataaatgtt aaaacgattt tgttgttcat agtctcacat ttgttgattc   127920

atttcagctt cataattatc actttactaa tgtatttcat tgattgcatc tggttcctct   127980

tattcacctt ttctctccct cttatgcaag gttgttcctt agctctgtgt ctattacttt   128040

gtatttgaag acttcagact gcttccgtat atcttgccct gttctttact atccttagtt   128100

ctacatgact tggcaaccta tataattatg aacatgacat gactctttgg gtctatgtgg   128160

ttttatattg tgctgctttt agattatcaa attagtaaat tacataatca ggattagagt   128220

tagcgaaaaa taaccttttt cacaaggtca agagatcgag accatcctgg ctaacatggt   128280

gaaatcccgt ttctactaaa aatacaaaaa ttagctgagc ctggtggtga gcgcctgtag   128340

tcccagctac tcaagaggct gaggcaggag aatcgcttga acccaggagg cagaggttgc   128400

agtgagctga gatcctgcta ctgcactcca gcctggcaac aaagtgagac tctgtctcaa   128460

aaaataataa tggtaataat agtaatgtat ttttctgtta acttggtagg agaagccaaa   128520

tcatcttcct ttcaaaatgt tttgtattca cccccttcct ataaaataac taataattaa   128580

ttctaacttt agtaacacaa taaccaactc ctttgtgact tttatttttt ctttcttttg   128640

gaaagataat gttaacaaat atttgtttta gttatatttg atgttaagaa atggtgaaaa   128700

aagcttgttt tcataatcaa tttttaaatt aattatattg atcatgctgt tatggttttt   128760

aatgaatagt ctgtcttttg aagtggtcag tggtttcttt tttctttcct ttcctttttt   128820

tttttttttt ttttttgaga gctttggttt aacatgatga aactcagcat agactttatg   128880

taatgcacca tgagagcaca ttagtgaaac cacccaaaag aaatagcatt tactcactgg   128940

gacccattaa aatgtttgag agattctctg ttatgtttac attcaattaa tagtcctttt   129000

aaagagaagg tatgataaca ttgctaacca gcttagttgg aaatctcttg ggatatacct   129060

ttgcacaaaa accagacagg cgctccatca ctcttgcctc aaaataagag aaagaaactc   129120

tctgaggtgt aataaaccct gagggcaata tttatgaaac ttcatttcag attgaaagtt   129180

tactaacttt tctaattagg atttttagtg tttttatttc ctcaatcata agaataatgt   129240

ttcccttcaa ttttaagatt gacaaaagta aatcccagag agcaaaatct tcttaaccaa   129300

agggataatt ttcttatcca ataatttgcc cctgagaaag ataaattctt tcttatatgt   129360

gatcattgtt tttaagttta agacaaattc taaagcacta agttaatatt aaaaaattca   129420

tctcattttt ttcgctctct ctggtatttt tattttccct gaaaaagatt aacttagagt   129480

taatttttga ccctaccctt ttactctgtt tttatatcat tttatcgaat gttctctctt   129540

aactaaatgc atgtagataa taattattta agtataggat gatacataat ttcagatctg   129600

agatcatgtt cactgtaatt aacattgtat aaatgaagct atgtgtagat tttccattca   129660

cctttttttt tctttttcat ccaatgttta tgtaaagtat agaattcaca gagatgtaac   129720

ctttcaaatt atgactaact gcttagaaga ttatataact ctttttgggg aatcaagtct   129780

tttaaaaatc aactataaat gacctattaa gccaagtaga ggactatgat gagtactata   129840

agcacaaaga gcaagcatta cagactcagt ttgagtcttc tgggaactta gaaacttcca   129900

gagagaaaaa acaggaacac ataaaatata catgataaca aaaacaccag agacataggg   129960

ggagagggaa acaccttgtt tgctgtattt ctatagagct ggaaattaaa gtgctagaaa   130020

ataaccttat atcaactgga tcaatgcact aattagactt cagaaacatg aaaagattca   130080

ttacaaaaca ttttctacca ggtgcatctt gtcaagagga ttctagtttt gttgttttag   130140

aacatacaac ttatgattat ctgaagttgt tacttgaaaa ctcaatactt gttaatgaat   130200

tatattgttt tacagaaaag gagatcaatc ttttagaaat atctaaaatt caaacttctg   130260

aaacaggtat caaaaaagtg ctgcccattc ttactttccc acctcctgcc ttcatctaaa   130320

atgaggtttt tcatctaaaa ttttatgagg aagaattcac tgtagttact ttttaaagag   130380

tctctctttt cttcagagta attctagttg ctttaataaa ctttaaattg attaaaattt   130440

ttcaatgttt caatcattct ctttctgggc ctcttatgtt catagctctg tttatcactt   130500

cttataaaac tttttactct ttggtttctc ttttactgca ccctcttggt ccttcttgtt   130560

catctctcat ttcatctact tcaaagtttt ctcctctacc tgtcctagtg atgtgtaggt   130620

aaatattttt ataaactggt tctccaagga aaataaaaaa tgtgtactta tatcatttac   130680

tataaatttt actgatatta ggatatatga cacacaattt acaaataata aaatattaca   130740

actttttatt gaacattctg tatatcaaat tgtttctcaa agaatgcttt ttttgaactt   130800

tgccaaactt ttgcatgtat aggcaaccta tttttgcagc taataaacaa gtatagtttt   130860

agcatgaaga ctgcttgata tttatgttag tcagtgaaat aaaaaagaaa tgaagaagct   130920

atatgtcaga actttactca ttcatcagtg atgtaagcaa ttatttgcaa atcaaaaaac   130980

agaatttcaa taatgaaagg atatttttta atttttgtgc tattcagagt aatggctaca   131040

aacacaatac accttgactg tttatctgtt ttattggcat ttcctccatc accttcttaa   131100

ttctactcta gaaaatcaag aagctctcat ttgtagtgct tggagatttt tgtaatgtaa   131160

agattcccac catcactgat ttcaaactac tgatgtgaaa ttgctaaatg cagagttaag   131220

aagagattca cagtagctca acagtgtgac atacttccac catccagata gaataggcca   131280

gatagaatag accagcatcc agaaagaaga gttgcacagt agcccaatag tatagcatat   131340

tactactgtc cagagagaat aatccagaga gaatagacca ccgtccagaa agaagagatg   131400

cacaatagcc cgacagtatg ccatacttct gctattcaaa cggaatagac aaataaaata   131460

cagtaaaata attaggaagt gatatgtctt agtatttatt acctttcctt aaggtaagtt   131520

atagaattct aagtttatat agtcaaatat ttaataatgg ctgcttttaa caacagacaa   131580

gcaggaattt ctgacagttt aacaacaaga attggtatgg tctgctttca gcacaccatt   131640

gaattctctc ccttaatatt gttgtttcag aatgtttcgg agttggccct ttttctgctc   131700

accctaaata ctctttttgt gtgacctcaa aaactgttct gacttcagca gatacatgta   131760

tgctaattat tactaagaat tcttttctag acaggttttt cccgtttcag gttcccaccc   131820

ccatttttaa aatctatagg atatctgtat ttaaacaatt cacaggcatc tcaaaatcat   131880

tacctgccga gtcagctcct cctcctgtgg ttttcaattc actgctaaca tccacctggt   131940

agtcctggga tccttccttt ctcttacatt tgatatccaa tcaatcacca aatcctgctg   132000

attttatctg ccaaatatgt cttgaatctg ttacaactct agttcctaac taatctttcc   132060

ctccagacag gatactggac cagaatccaa atggttttct gggtatgaaa ctttcttcac   132120

ccctactcct ctctattcac ccttccaact tatcctccat gtaccgtgga gacatctatt   132180

tacattgcaa tttgcgtatc tcgttccctg cttataaccc tttacttact cctcaacctc   132240

aataggatat aagccaaact ccttaaggta aaggccaatg ctttccataa tctgaccaat   132300

ttttctaagc tcacctctca cccttgcctc ttgtgtacat tctgcttgca tcacaattct   132360

aaactggttt aaatttctat gcataacaat ttttgctgcc tggaattcca cccaaactct   132420

tttttactga tattttgatt caacccaggc tccatctctt ctaggaagcc tctactgatc   132480

tctctttctc aagaaataag ccaggtgaga ttgatttctt ccatgctatc aaaatgaacc   132540

ctgactatct gtcactttag ttgccatatc tagttatagt catttatttc tgtttttatc   132600

tacctaacca aaacctaaca taaattcact gaggaaagga aatcatgtac agaggtgaat   132660

acataaaaga tacgtaacaa gggtttgatg gacaaaagaa tgcgttaatg aatgaataaa   132720

cctaaccatt tttaagtaca attttcaatt ttttgtagca gtatattttg tacataaaaa   132780

tttaaagtca catttgtttt taacttagaa tacttgaaac agtttcatct ggatcttcta   132840

atcaagatga gtttcttttg aacttaattt caggagtttc cactaatttt ctcaatattg   132900

tttagaaagg tgtatttcag agggttttta ccatagagga gtggaagtat ctaaaattat   132960

agactagaaa aatttatctg tcagaaaaga agaccctaaa attcatgtcg tcttcagatt   133020

ttagttcatt cattcattca cacataaaat gaaagtggtt taaagactgt ggaggagact   133080

gaagagaaat tggggattac agaagacaag aatacattgt aagctaaaac taactaacaa   133140

ctatttagaa aacatcatgc aaagttagaa gatgaaggaa ggcagcatcc aaattaaatc   133200

tatctgaaat tgcaagtata ggtgttgaaa ttatttggtt gagggagtat cacagaaagc   133260

agtttgcatt aaataatgta ttaaaaattt tatttattct gaatatcaag atttaacatg   133320

catgtctttc ttgtcaggtt gtgtatggag gttctcatgc tgccaagtta acatagagtc   133380

agggaaagga aaaatctggt ggaacatcag gaaaacctgc tacaagattg ttgaacacag   133440

ttggtttgaa agcttcattg tcctcatgat cctgctcagc agtggtgccc tggtaaatga   133500

tctgacacct aagtcaatat attgattaag tcaatattct ttaaaatgag ctaaaagata   133560

aaaatatcat ggcaagttgt tttacctaga attaatccct atgattagtg ccaatgacaa   133620

aattttactt gagctcagta aatagttact gagcactcct acatgccagg cattatcctt   133680

gctgccctga atgctgttgt ccaaaggacc acccagatgg ctataataga aaagagaatt   133740

ttactggcaa tatcagtttg caaaacaggg agagagtctg tggcataaac tgaaagcact   133800

ttccctgtag aacaaagaga gaaggttaga ggttttatta aaatgggaaa atgttatata   133860

ttgctctttg agaaagttca ttggccctag taaggatctg gggaactggt aagctccaac   133920

tggcgagcaa cagtcgttgg cacaattagt cctagagtgt aacaggtttc ctcagaagct   133980

atagataaaa ctaatttcaa gttacaacaa gcagcttcaa cagtcagtct tgcagagaat   134040

tataattctt ggagtaatgt tttgtaccct gagagctttt ccccctgcct tcttgactct   134100

tagttgactg ttagttgagt aggacaagaa ctacccaatt tgtatgatca actttcacaa   134160

tgcaaagata aataagatcc aggtactgtt tattcttaag gagctcagag caatggagaa   134220

gagaagaata caaatgagta actgtagagc ttggatgtgt ttgtaagcaa agtgtaaatg   134280

tgacaaagtt ctgtagcaag gagaacaact gcttgcaatt tcagaaacgt aaatggtgct   134340

tttcagggtc tagaaagacg aacaggaatt ttctagttag gcaaggcagg ctgaggggaa   134400

caagtataca atcgtaagga ggcataaaac agcatcagat attcaggaaa ttaaaaactg   134460

ctgaactgca agtgtggtgg gaagaagaac aagtacaggt ggccagagat actatgagaa   134520

agcaaggtca gcttgtgaag catcttgtgt gttataaaaa gggaaaacag atggtagttt   134580

taggataaaa gtaggacaag tttctcattc ttgtacacat acaagcagct tccatgagag   134640

ttgaaagaga tctagtagaa ttacaagcta cctgaacctt tttcttaatt gtcatttttc   134700

ctgctgacgc tgacagagat gagccattag aagccattag gagcccagat ctagctagat   134760

ataccactgg aagtttcatt atactaaaaa tagaatactc aagaactttg taacttgcct   134820

catagacagt cttcatgagt ttggactttg attttactgt acttatatgc taataggttg   134880

atctgatact gtttcatgga tgctggcaga agatatgagg tgcttgggtc agagataaag   134940

gactttgtta cttatgtgtg gaaagtagca tgagtttcaa catgtttctg ttggttcccc   135000

ctttacccag gtctcatggg ggcattatat gagcctgaat gagtgtgtac acatatagtg   135060

gattgatgtc acagctgagg aacactgagc ttagggaatg catcctttta taccaagcaa   135120

cataagcaac cctgctcttt gtcccagaga ccctacctca tgtctcaagg ttgctcactg   135180

caaacacaac cctgaggaat gtcctaggta aggagcaggc agagcctggc attcttggca   135240

cactccccaa caacctgcag ggacccactg tggctttcct ttcctatcaa gtctcaactc   135300

tcagaaacag aaaatgtgat cagaaaagct ctattttcct tacctggagt catccaagta   135360

gaaatcatga tagtgtctac catgcaatgt attcctagta actaaggagg tttatcccat   135420

gctgactcac atatgtgact gagaatttca gagaggagat tacaaaaaaa ttaaagtttg   135480

gagtaattcc ttgttcaaaa tgtctaaaac agaggaagac atttggggag ggcattctca   135540

aaagtgtatt ttaaataaat catatgagga agaaaaggga aagatatttc aagaagctgg   135600

tgtttgtact tagacaggtt gccaattaaa ctagattttt taaaagtata gcaaaccccc   135660

atgacacgtg tttacctatg taacaaacct tcacatgtac cctcaaacct aaaataaaag   135720

ttaaaaagaa gtaatagctc tcatttagct tatacttatt gtgtttcaga atcttctttt   135780

agattttctc atttaatttt caaacaaccc tgtgagatta tgatattttg cttattttac   135840

caatgatgaa gctgggtaca gttttaaaag ttgcttaatg tcccaaagct agtaaatgac   135900

agagctatca ctgaattgac atctaaaatc aaagtcacca tatcttttca ctgtgttgtg   135960

gctcctcaga aagaagagta tacacaaaac agaaataaat gagtggtaac tgaatttagt   136020

aacagtaaag cgttaagtcc taaatcagat agagctcaca taaggtcatt cttgcctcct   136080

tgctcctaca tccacaaaat tggttctgga agctagaacc cctgtgggct gaattctaat   136140

tcctgctctg ggaccagtca gagagaggtt ctcatcatca agacttcctg cggctctgct   136200

ctgaccctgt acaccagttc tagaaacagg cttcgttttc cttgtgacta agccccttcc   136260

ttgtctttgt atttcaagga ctgagtcatt gccatagttt cggtttagat ggcttgcctg   136320

attcctccag aatttggggg tggagtggag gggaggaaaa tcctgagggc tagaagcctc   136380

cctctgcact tcaattccat tgaatttcag aacctctgcc aactgctggg accttctttt   136440

tgcatcttag taggtccatt cagtctttct gccccaactt gtctcttttc ttcaatattg   136500

ataccaacag tttcccaaaa ctgctaagga taattttaga gtattgaaag cagaacgtag   136560

aataagaaga atctgaatgg cacaagttca tgactgtaga caggtaataa atataatatt   136620

aaccacgaag gatacaggtc tttgactttc attttatcca acagggttaa tagtgtttcg   136680

atctgaaaga gaaagttcta acactttaga cctgttgaga tcagcaatca ttttcagtgt   136740

ctcaatgagc cttttttttt tttttttttt tgagacagag tcttgctctg ttgcccaggc   136800

tggagtgcag tggcgtgatc ttggctcact gcaacaatga gcccaatttt tcagtccttt   136860

caaattcttt gtcaagggac atgtggctga agtctaaagt caaagtcacc ctgtcctttc   136920

actgtgttgt ggctcctcag acagaagagc atacacaaaa taggagtaaa tgagtgataa   136980

ccaaaattag taacagtaaa gcgtaagccc tacattagat agagctcacc taatgttgtc   137040

acataatgtt gtgtgtcact tactaaaatt tcttggaaag cataggaagc accgcattaa   137100

tggagagaat agaacagtga tttttagagc tgaagctttg aaggataata tatggatgaa   137160

tagtcaaagg aaaaagcacc ctctgtgttc tataggccta ttaagctact gcagtcattc   137220

atttagcaaa tctttccttt cctgctgctg ttattaacat ggtactaggc actgggatgc   137280

acaagcattt gagagctgaa agacaggctc cacatcctac tggtggggaa aaaggggagt   137340

gtaggatgtg aaaagtttat aacagtggct ggccatggga tcatgtctta aattgctagg   137400

acttatccaa ttttaatgga gaaagaggag gaatcagatg gaggtggaaa tgatcaggtg   137460

tcagagatca tgagtctttt tgtggattat aagtaatttc attcttttgc actttctctt   137520

gacctctgaa gaccagcagc agcactggtg agaaggctag aactaactgt tatatgataa   137580

ctgtaaacca gaaaaaatgt cagctggccc atgtcaatat tatgtttcag cagtcttagc   137640

attagaattg tatttttcct gtttttttta aatgaatcat gaagcttaag ttgtgcatga   137700

ttgaaacttg aatattattt ccacaggctt ttgaagatat ttatattgaa aggaaaaaga   137760

ccattaagat tatcctggag tatgcagaca agatcttcac ttacatcttc attctggaaa   137820

tgcttctaaa atggatagca tatggttata aaacatattt caccaatgcc tggtgttggc   137880

tggatttcct aattgttgat gtaggtactt ttgagtacat tttaaaagag gatttattct   137940

tactgtgtgt tgtgaaaaaa ccttcaccac tattgcatat tatcatattt taattttgtt   138000

aagcttcata tattttcagg ctataggttt attcttttag aaatattaac acagccagtg   138060

gaaatatatc tgtgaggaat attagaacag aaatcgttca acaaatgtaa attatttctg   138120

tgacattgta acatttataa ttgagttttt tatgttttct gcaaaggaga tgtgattttt   138180

taaaaaatat gatttgaatg tcattcttgt taagaataaa acaaaattta gaagtaggag   138240

atgataaaag ggcagagaca cagattaaag agaggaaatg atgattattc ataatgtaaa   138300

attggaagat aagagaggat gaggggcaca tcaagttggc tgatatgtga gctaaaattt   138360

ttctaaaaat cattatacaa atacaaagtt aactttgtat ttggggagag agaagtcatg   138420

aaattttaaa atatctatct cagacccaat tataggaaaa accaaaatga gacacaattg   138480

tctctatctc aaatatgcga cttgcccttc atctccagaa tggcagtggg gcagaggagt   138540

aggcattatt attaatgtaa taattttaga taataaattc aaagaactgt tgaatacttg   138600

gatgatggaa aatacataat aattctttag tttacatatt attttaacga agtagaaata   138660

tttttacagg cttctgattg agatagagaa gaaatcttaa aatagtcggt gagatcaagg   138720

actctcaaat agaaactaac ggtacaatac ccattattat catttcattg aatgtactct   138780

aattatttta tattttaata atataactta ataatatata tgacatattt tgtattaatt   138840

aaaatggctt tcttacatta ttttataacc tcaatctccc agtcttattt ttctcagaat   138900

gatatgttct ttatctttta ctaattcttc tagattttca gaaacctaac ctttgtgttt   138960

agggaagaaa catcctataa tcagtcatag tttttagaga tttgttttcc atatgatgcc   139020

tgacataatt agaggtcaac acgcaaattt gtatatgcca ataagtgctt taaaatttaa   139080

ccaagggttt gcattatcga gcttttaaga aaagttgaat tcatacagca tcatatgtgg   139140

attagaaaat cacaagtaag catgatcata catagtaaaa tctgactgca aaatgttacc   139200

aaattagtca tatttactca aaagttcaat ttctcaactg ttattcaaag cttcataaac   139260

ttttggcttc tggccaggcg cggtagctca cgcctgtaat cccagcactt tgagagtccg   139320

aggcaggtgg atcacctgag gtcaggagtt tgagaccagc ctggccaaca tggtgaaacc   139380

ccgtctctac taaaaaatac aaaaaattag ccagacatgg tggcaggtgc ctgtaatccc   139440

agctactcag gaggctgagg cagaagaatc gcttgaaccc ggtaggcaga ggtttcagtg   139500

agtcgagatc gtgccactgc actccagctt gggcgacagg gtgagactcc atctcaaaaa   139560

aaataataat aattttcgtt ttcttaatca cacaacatat taaatgttaa aaacaataac   139620

ttttttctat aatatgtaat gtgaaaaaat ttttaacata gctatatatt acaccttata   139680

tgtgttatct taggtttcct ctatgagaat tctaacttcg gatatagtaa tgatttcttg   139740

ctatttttca attaatcatt catatatcaa gttatctagt tactgcctaa aaaatgaaaa   139800

atgataaaat gggtattttt gtaatatagt agttttgaag aaaggctgcc ccaaataaga   139860

agaaattata gaaggaatgt agattttctt ttctcttaaa ctgtaaatat gacggggtct   139920

ctctcttaaa aaattataca atattttaga tattttaaaa tctttaaaat attatcacaa   139980

atacactcat tttcatcatt cagtgtaaga aatgaaggtt tacaagtaaa attgaactta   140040

ttttaaatta agagatatgg ctgtttaata atggaaattg ttttatttga aaatttaaag   140100

tgatgattct cagtgagtat aacctcctgt tcaggggtat gtaatgtgca gaaatcaggg   140160

agataaacaa ctccaatttg aaatattatt taatattttg gaaacgaaca aatataatgc   140220

aaagcacaga gagtaaagct ccacacaata ttcttgctga cagagatgca aattttggga   140280

cacagatttg ggggagtggc tgattttttt tttttctgaa aagtatagaa acttatctac   140340

agcagttgtt cttgaaggat ggtctcaaaa ctgaaaacgt tggcacatgt aggtgagaac   140400

tcataagaga tgcaaattct gcccccaacc ccaagacata ctgaatcaga aactctgggg   140460

ttggatgtgg caaatcattg taacaagccc tacagatgat tctgttgtat attcagattt   140520

cagaactact tatattattt gctactcaga gaatggactt gtctgatttc tgcaggcttc   140580

tgggttattt gaaacttact tgattaaaca gtgttcttca gtacaggcgt atatttgtat   140640

atatacgtgt gtgtttatag aaagatgtga atatatatgc atatatattc tcagttacaa   140700

actataccat agtcttaata atatgcatat attccgtgtc ataaaactca cttaacagtg   140760

gcttggagaa cagacctatt agtattttag gggctgtatc aattataaca gacatgtctt   140820

agtctacctt ttattgctgt aactgaatac ctgagactgg ttaaagtatt caataaagaa   140880

atttatttct taaagttctg gaagctggga agtctaaggt gaagggtcca catctggtgg   140940

gaactttctt gctggtgggc acaccagaga gtcccaaggc agctcatggc atcacatggc   141000

gaggggtgtt cactgagagc caaactgggt tttataataa acccactctt gtgatatcta   141060

actcactccc atgataaccc attaagccct tactctatat tccattcatg aaggcagaac   141120

cttcatgacc tcatcacctt ttaaaggctc tgcctcttaa tactgttaca ttgggaatta   141180

agttccaaca tgagtttcaa aagggacaaa cattcaaacc acagcaaaac attaaaaaaa   141240

aaattttctg attaaagagg gagcatacat attttcaagt gttcttaagt ggaaaataat   141300

ggatgtgaat gactgggcaa atttaagagt ggcatgagga gtaatttatt ctgctaaata   141360

cgtagcttta ggaatttaaa aaaaaaagcc atgttacatt tagtgagaca tctggaaata   141420

ctacatgagg atgagcactt taaaacactt cccgcttcat cagtcagttt acctgtctct   141480

gatggtaaca gcaatgaact ttttgtgaac aatgactttt tctacgcctg aaatagataa   141540

atatataaag ttggctctca tctgttccta ttcttccctc gaaaaattga atctctcagt   141600

cactaactta ttcgtaatga agaactgcat tccagacatt tttcttagac atcgtctcct   141660

gctacacagg atgtgaggca aatgaatatt ttccatggaa ctaattcaga gagtaaacat   141720

atttatagat ccagatctaa ggtcatggag gagctcattg ctttgtaact aaaatgtgta   141780

ttgattgtat tgctgttcat gttctttctt aagataattt acgataagaa ctcaaatttc   141840

ttttggatac tggttatggt aattgtggct gatctatcta acatgatgaa gctcttatta   141900

tatctatatt gattgtgaag ccaatgagat cagctactct cattctctct tcagtacaat   141960

tgtgattttt ctcccatgaa aaactatttg gtagatcttt ggtgctaatc tttagaaatt   142020

gtagggcaga agcaatcttg ttgagaattt gccccaactc aaaatcatga gtcttcaaaa   142080

tgttttttaa taagatttat actaagacat agatttagtt gagtgaatac cacactttta   142140

gggcttagct tcagaatcac acacttcatt ttgacctgag ttttataatt aaaatgttca   142200

ccattgttct aattaaattt ttagatttaa taaggaatta caaagcaatt gattacaaaa   142260

gtgtgaaaag catatgcatg atttctattc aaatagaata aacaacttac tttgcttaca   142320

ttatttcttc ttattttggt taaccttctt ttaaatctat ttccttacag aaacatccat   142380

cttaccctat ttttaggcat tgactacaca actccgtata taccatctta ttgttcctgt   142440

tgagttgctt ttagtgagtt tcagaattga ctttttcctt ttatgcttca tcattttatt   142500

gacacaatta atgaaaatgt tatttttata ggtttctttg gttactttag tggcaaacac   142560

tcttggctac tcagatcttg gccccattaa atcccttcgg acactgagag ctttaagacc   142620

tctaagagcc ttatctagat ttgaaggaat gagggtaaga aaatactaaa ctttataatg   142680

ttcttatttt ttaatggggt ttaaaatata aaaacaatgg gtatgtagaa attatgagtt   142740

gtttctgttt acataaatac ataggctgtt tatgtatgtg tgtgtacata tacatatata   142800

catatgcata tatgtatata tgcatatgta tactatatag tatgcattta catactatat   142860

acagtatgca tatatactat atatagtatg catatatggt atatatatgc atattatata   142920

cactaatagt atatatatgc atattacata tactaatagt atatatgcat attatatata   142980

ctaatggtat atatgcatac taatatataa atactaatta tagcattaat taaatagtat   143040

attactaaaa atagtataat actcattagt atatactagt atattactaa aaaagtataa   143100

tactaattag tatatactat tatatattaa tatatacaga atatgaaaga ctatatataa   143160

aatatgcata tatagtatag tatatatatt atttcattta ctgtacatat tagtatatat   143220

atgcatactc tctctctctc tatatatata tatatataca cacacagtat ttcagtgcat   143280

attgtttaac aagggaataa gttaatcaca gtaatcctgc ctttatctaa tattgtcaaa   143340

caatagaatg atccaaatga gtgacttttt tcatattaaa tggaaatctt ccctgtgcta   143400

ggaagtccaa gtgaaagggg aaactattgt tcctaacatc atctctcata cataagtaat   143460

caaggaccta cttatatcag gtgttcaaat aatatttgtt taagaaacta cctgggtaag   143520

gagcattaga aaagataggt aagtgagaca gcatcagcca tcacatttaa tttcaccttt   143580

aaaataacat tgcaaagtaa gtggaattat aactaaatta tatttgagaa aactaaagct   143640

cagagagttt acttaatttg cacttaggct gcagagtgcc tgaaaagata ctcaattagc   143700

agagacaaac aagttataat gaataacaac taccataacc tagctttaag gattgtatta   143760

aaccagcaac tttgtaacac acatggagga caacaactct attttctgta attagtccat   143820

atcctcatgt gttggtactc ctctaaaatt tcttctccag atttatacct gctattttat   143880

gcctctgttc tggaatgctt cccctgccct gtcccgaccc taacccgttt gtatagcaga   143940

caaacaccta tctgtccttt aaggctcaat ttaaagttgc cttgtccgtc caccaggaga   144000

cataactgga tattctctct ctgttcagac acctaaaatc ctcattatat tgtattttac   144060

ttatttgttt acttaactgc ctccctacct taccttctct gagcaattta acacggagat   144120

tagtccagct tactgatact ttaagtgtgg tttactgacc agctattagc attatctaca   144180

aacttattaa aaagacggac ggatcatgag gtcaggagtt cgagaccagc ctggccaata   144240

tggtgaaacc ccatctctac taaaaatgca aaaaattacc cgggcatagt ggtgctcacc   144300

tgtagtctca gctactaggg aggctgaggc agaagaatcg cttgaacccg ggaggcagag   144360

gttgcagtga gccgagatca tgcaactgca ctccagcctg gggaacagag caagactctg   144420

tatcaaaaaa aaaaaaaaaa aaaaagcaaa ttcttggatc tcaccccaga cctactgagt   144480

cagaaactcc aggatgggga taagaaactt gggttttaac cagcctcaag tgaacattag   144540

agatctttca gcctaccaaa tcttcactgt tatccctaca aacctaatta tgactgcaat   144600

ctctgctatt ttaattatcc agtgtataac ggtttccaag tataaaagaa agatcatgat   144660

tatacaaaaa agttcataag cacaattcaa aaatattcta tctacaagtt gaaaattaca   144720

agtttcattt tgtgcagaaa ggtggtatta gaattcattg acattaactt aattttttga   144780

gcattaatag aatgttacaa tctatcacaa ctttccccta caaaaccact tccttcagtg   144840

attaagccag cccactattt aactctgttt gctctttgtt ctttatctgt attacaggtg   144900

aattggatgc aggagaatag tttagtatat tttgagaggc aaatgtctat ttagttacat   144960

ttgttaacca tgcaaaaaga gacatttatt catgccgcag ggctattttg aaggataaat   145020

gaaataatga aataatgcat ttgaggcata ttgtagtcag cttgtttgag tccttaggct   145080

ctttagcttt cccaactggc ttctcatcag accaataggt gcctgtcttt ctcagagacc   145140

catgattcca tcattactca cattttttag aaaaacattt taaacaccaa ctatgtgtca   145200

ggtgttgtga tataaaaaac acagagtaca gtggtacata gaccccggtc cccaaagagt   145260

gagtagggtc aatggttaca agagagacag acaagggcac ataatgatac aggaatatac   145320

agtagggagt ggctatccgg ggaagtctgg gaagacatca caaggaggtg acatttcaga   145380

catttcatga ctgaagagta agccccaaat cataggcaga taggcattca aggcagtgat   145440

accacatggt agggaggcac agaatagatt gtgcaaggtg tgcttggtca gtgactagat   145500

gtatcagagt gcctacgtga taaacatagt agggagggca gcaggaaatg agcatgaaaa   145560

ggtaggctct attaagagct ggctactttg aacttcattc tctattccta ttcctcctaa   145620

tcttttttga ggtcacatag actgtaagaa tctgatgaaa gttagaattg tctttccgga   145680

aagacagcac aaccataatg tttgttatat aatttcatgc ccccaggaaa cctctacagg   145740

tccatgaact ccaaataatc attgctctgg accaaaggtc aacaaacccc agcctgtttt   145800

tgtaaaaatg ttcttggaac acagccatac cagtttgttt atgtatgacc catgactacc   145860

atggcagagt tgaatagttg caacggagat ataacccaca aagcctaaaa atatttataa   145920

aaatgtttgc aaaccttctc cctagatgat ctgattagta gtcagagatc cttagtattt   145980

ctctatttta aagcatcttg agaacctgct taatacattg cagaaaagaa ggatcccagt   146040

gctccttccc taacaggtta atctttaaca catttgtact tgaatgggtg ctcaagctga   146100

agtgtaagat gacaggtagg ttttgaaaga ttaagtaaat aagaaaatct ggagagtgtt   146160

aaatgccaca ggaattgccc tggatgaaaa ctggagtggc aaagacaaac tggtgatcaa   146220

tagcagtaca aatgctgaaa agcagaaata aagaaaggat taaagaaaaa ctgttcctaa   146280

tttttgtctt aactgaggcc agcactatat atatttagtc aaaggcttac atataaagta   146340

tttagagtaa taataataaa tttaaaacga ttgctcttat ttcgtagaac cagccaaatc   146400

taaaggattt aaaccattta aagattctca atccttttgt ggagaatgtc tcaaaaaaag   146460

agaataagaa aagaaaataa ttaaattaaa ttaaaatgat gtccagtcat aattccacct   146520

acctgatata caccaatagt ttctctatgg gggaatcttt aatgctggta ataataggat   146580

catgaacatt taaatgtata taaatatata tttttcattt atgtttatac atttcttttt   146640

tttccagagt gtacagattt tacaagttta ccttatcaat aacaggtttt ggtttattat   146700

ttttatttat tttacattta tttaagctat tatattatct tagttatttt gtcttatatt   146760

ttgctaacaa ttttattgtg tgataatcat gtaatttgta agcctggtga tcacagagtt   146820

catgtcttat tttgtcttgc ttggcacact gctgagtgta gagtaggcat ttaataaaca   146880

tgagtcggct ggttggtttg atgtcttaga tatttaaggg cggcttttct aatttattta   146940

tgtctgcatg gcatttcttt catgttgcct atttaacatc ttactaatcc taatcatgct   147000

tttctttctt ttgaatacta ggtcgttgtg aatgcactca taggagcaat tccttccatc   147060

atgaatgtgc tacttgtgtg tcttatattc tggctgatat tcagcatcat gggagtaaat   147120

ttgtttgctg gcaagttcta tgagtgtatt aacaccacag atgggtcacg gtttcctgca   147180

agtcaagttc caaatcgttc cgaatgtttt gcccttatga atgttagtca aaatgtgcga   147240

tggaaaaacc tgaaagtgaa ctttgataat gtcggacttg gttacctatc tctgcttcaa   147300

gttgtaagtg tcccatttca tgagtgcttg gtattttaat agatattgga cgaaggatat   147360

aagttattct ttaaatagta tattaattat aaattgaaga taaaatactg tgtggttttt   147420

aaaacagtgc cagtcttggc cgggcgcagt ggctcatgcc tgtagtctct tcactttggg   147480

aggccaaggt gggcagatca tgaggtcagg agttcgagac cagtctggcc aacatagtga   147540

aaccccatct ctactaaaaa tacaaaaaaa ttagctgggt gtggtggcag gcgcctgtaa   147600

tcctagctgc ttgggaggct gaggcaggag aatcacgtga acctgggagg cggaggttgc   147660

agtgggccaa gatcgtgcca ctgcactcca gcctgggcta cagagcgaga ctcttgtctc   147720

aaaaaaaaaa aaaaaaaaaa aaaaaagtgt tggtctttcc tagaacatgt tcctacatga   147780

ataagaagca tgggttctgt tgcatttgag ttattaattt ataattgact ctttggtgtc   147840

atgtggactc ccatcttgca ccattcaaat attgcttcaa aaatgaacgt ttttgaactt   147900

cctgcttcac actatgaagg gatgagagga acttcccaca ggcatggaga accctttaaa   147960

aaatggagaa aagatgtttc ctgtcttatt cataaaattt tccttcacct ttaaaaaata   148020

aaaggttatg tgcgaaattc acaggcaact gtaacaattt agaaataatt aactgggact   148080

aagatttaga atgttacttg ggaatatgtc ctttttaaaa aaatctttac attaaatgga   148140

catgttgaat acagcaaaac ttactagtat tacttaataa ttgtggtaac attaaacaga   148200

caaaactctg tttatggcta ttttagaata tgagcttaac attcaaattc tattaatgtt   148260

attcttaaag gcaactttta agggatggac gattattatg tatgcagcag tggattctgt   148320

taatgtaagt attgattatc ttagcactaa actttatttt taaaagcttc ttagtttatt   148380

tcagtgattt ccaaactata acttcatgaa gcccttggga ctcacataga caatgaagaa   148440

catccacctg atagtagcct agtggttgtg agtacagcag ttggagatag agcctgattc   148500

aaattctagc tgtaccatat catccaagct ctacaactga cttcgggcaa attaccttac   148560

cttcttgaga cttagtttat ttgtctaatc tataatttaa tgaatctatc atttgtctaa   148620

taaatgtcta caatcatcca atgcctactc catagtgttg tgaggaccca acaagaaaat   148680

agaagcaggg cacttagtgc aggctggcat tactaaatgc tcagtaaata tgcgcttatc   148740

aaaataaaaa taaaataatt ttaatgtata gcttttactg tttttacagt ttaaaacacc   148800

ttggatgagt ttatgtgaaa taagttccat gctaagaaac tttaatgatt actccctagg   148860

taatattttt acaaaatata ataaagatgt attcggaatc aaaagaaaat acatggcaaa   148920

atgtgtataa atatgataat gtctcattta cagtactttt ggaaataaca tatacatagt   148980

atgtcactta gttattgaat tttcctacca atatgagcac aaatatgcat atgattaagc   149040

cctttgtagt tatttgaaga ttatattatt tattacataa gtatgtaata aattaaataa   149100

taagtatgta atgaatacat gttgaataaa ttgttaagag tgattatgtt aaacctcaac   149160

aatgctatgg cttcttaaat cctatgttta cctaggatag cactgtttga attacctggt   149220

caaaccatgt gaaaaagaaa ataatgaatg ttactgtcca tataatgcta acttttgtaa   149280

attttatagg tagacaagca gcccaaatat gaatatagcc tctacatgta tatttatttt   149340

gtcgtcttta tcatctttgg gtcattcttc actttgaact tgttcattgg tgtcatcata   149400

gataatttca accaacagaa aaagaagata agtatttcaa atatttttca ttgtaatgaa   149460

agggatgaac aattattttc caaaaaagat aatgtaaagt ttaatttgat atcaattcat   149520

gattaatttt attagaactt catttatttt tcaaataatt gactagtata caattacaaa   149580

tatgcttaat cttattcatt tttgcacaga aaacaatttt ctaaataata ggttctggct   149640

aacttatgat ttaggttaaa cccataggtt ttgagcaata tatcaactat tctgtttttt   149700

ccaatgtttc ctatagagga ttgaataatt aagaaaaatc aatacactat ttattcaaaa   149760

cacattttat aagtagttat ttattttatt ttgtgtaata tatattgggt tggagcttgg   149820

ggagaccaac gtaagatatg gttcctgagc tcaaggagtt tatgtcatag cagaataaat   149880

aacacaggta atgaaaatta agacttgttg aatactgtaa tttgagcaat cttctgaaat   149940

ttttaattaa ttaatcttca catcaactgt attagtttct ttgacctacg agaacaggat   150000

aatacaaacc tgagggctta aaacaagaga aatatattct ctcacacttt tggaggttag   150060

aagtccaaat tcaaagtgtc agcaggtcca tgttctcttt aaagcctcta agaaaatata   150120

ttttattgcc tcttccagct tctggtagcc caggtgtttc ttggtttatg gcaacagaac   150180

tccaatctct cccattatag tgacatgcca ttttccctct gtgtgtcttt ctcctctact   150240

agtaaggatg ccagtcacac tggattaaga gcccactcca ctccagtatg acttcatctt   150300

aattacatct gcaatgacat tattttcaaa taaggtcaca ttctgaagtg ctaagggtta   150360

ggacttatat gtaccttctt agggcacaca atccaaccca taacatcaat cacaaaagta   150420

ttattacaga gtctctttca caaatgagga aaggcacaca gaggttaagt gacttaccca   150480

aggtcatata tcgagtatgt gatgaaggtt agatagagtc agtagtaaat tcgatgtatc   150540

ttgtactcta ttaaactctc tactatgctc tatccccaaa tactataatc atgataaata   150600

caataagaaa aattaacaag cacaaaaaat atacatgaca gtcagagtaa aaatagatgc   150660

tgctatagaa tggtttatga aatacgtgac aattgagaag gctttggaag gtgggaaaga   150720

agacatgtag caacggagag gcaaaagaat ggctaaccca catggagtga aacagaaatg   150780

aatgagcaaa tgaattgtgt tgataaaaga ggcagcaatt caggggggat agcaatgctt   150840

tcggttttga agaaatttaa gatttggaga aatagtaaaa gatgaggttt taacctgcct   150900

gagagtagat ataaaaagcc gtattagacc ttttttaata gcagctggtg tttcattcat   150960

atatgttgag tagggaagaa tatggaagca ggagattgat gtttattaag actccatgat   151020

atgtcagatc ctgtgtaaaa tacttctaac ataattgtag tcaaatttta caacaaatct   151080

aaaagacata gtatcctcat ttaacctctc agaaaaatta tcttatttgc acatggcctg   151140

acagctaaaa agtagtttca ttatggatct agctccagaa ttgctttttc tagagactga   151200

gctttacaaa aaattaatct agcagtgatg cacaaaatga ctagggaagg accaaagact   151260

atttcagacc ctgcttgacc tgccacctgg accacactaa gtctccaaat tagtcctgtg   151320

tgtcaatgga gaataggaaa tatgttccat taaaacattt tagagggtag aatctacagt   151380

attgcttgtg atttgcaaga gataaaggag tctaattctg gagtttcttg tcaactaact   151440

gagatactct ggttgtggta ccacctatac aaaaagagat ctttggagac taaatggtag   151500

aattacaaaa gagaataata attttgggta ctggcttagc atctaagaag acagatgtac   151560

atgtaccaaa atgtcattag tgtgcatgat tgactatttg caagtagaca aaaatttagt   151620

aaatattgca ttatttatcc tgacatttac aaatacagat gtttattttt aaagattttt   151680

aaatttcatg ttccatttta catttataaa gtgtacactg attttcaatt tatttttctc   151740

aacttaagca ttatatatac atacatgtaa tatataagca cacacaagta attcctcagt   151800

cttccctgca taggataaat taagcgtgtc tagaaagagc agtatgagca taaataaaac   151860

agccaacatc caattgactt taatcttcct gcttgttaat gttattctta caacatttct   151920

actgcaggaa gtaaaatagg atgggttgat actatcacca ccaaagtcag gaaacagtta   151980

ctgatttaga agcatcaaaa actcatatcc cctatcattc ttccagtatt tcatcttgca   152040

atctaagtat agcttttatt ttctgacctt ttctgaatga tttagaattt ctttccactc   152100

ttccctgaaa aaacatgacc aacacttcaa ttagttaaca catgctatgt agaagtacgt   152160

agtagatgct ttgtgatgaa ctcatttatt ccaaagaaaa aaaacaaatg aaagtggtat   152220

ccttttcttt gcctttccta attttaatta ttgtggtaag gaaacttaat atgagatcta   152280

cctgcttaac aaaattttta agtatactat atatattgtt aactatagtt acgaagtact   152340

acaggaagtc cctagaactt attcatcttg cataattgaa actttattcc cattgaatag   152400

caattctcca ttctcccatc ctttcatgcc ctggcaatca ccattcttct ctctgtttcc   152460

atgagtttga ccattttagt tacttcaccg aagtggaatt atgcaatatt ttttctgtta   152520

cttcactcag cataaattta tccaggttca ttcaagttgc tgcatatggc aggatttcct   152580

tctttataag gctgaatagt gtgtgtttgt gtgtgtgtgt gtacgtgcac acgcacatgc   152640

aggtatacaa ataccacatt ttctatccca tcattcatca atagacattt aggttgtttt   152700

catatttgga tacagtaaat agtgctgaag tgaacatgga agtaaggact ctgagatcct   152760

gagttcaaat ttttaaaata tgctcagatg tggcattgct agatcaaatg gtagttatat   152820

ttttaatttt ttcaggaact ttcatactgt tttctatggc agctacatca ttttacattc   152880

caacaatgta caaaggttct aatttctcca tatccttgcc aacacctatt atcttttgat   152940

ttgggtggtt tttgtttttg ttttggtaat agccatccta gcaggtatga aatgatatct   153000

ctttacggtt ttttgttgct gttttttttt tttttttttt ttttttttgt tgtttttttt   153060

tttgagacgg agtttcgctc tgtcgcccag gctggagtgc agtggcgcga tctcgactca   153120

ctgcaagctc cgcctcccgg gttcacgcca ttctcctgcc tcagcctccc gtgtagctgg   153180

gactacaggc gtgcgccacc atgcccggct aatttttgta tttttagtag agacggggtt   153240

tcaccctgtt agccaggatg gtctcgatct cctgacctcg tgatccgccc gtctcggcct   153300

cccaaagtgc tgggattaca ggcgtgagcc accacgcccg gccttgttgc tgtttgtttg   153360

tttgtttttg aaggagtctc actctgtcac caggctggag tgcagtggcg cgatctcagc   153420

tcactgcaac ctccgactcc ctggttcaag tgattctcct gcctcagctt cccaagtagc   153480

tgggattaca ggcatgtgcc accatgccca gctaattttt gtattttcag tagagatgga   153540

gtttcaccat tttggccagg atggtcttga tctcctgacc tcatgatcca cccaccttgg   153600

cctcccaaag tgctgggata acaggcatga gccactgcac ctggccctca ttacagtttt   153660

tatttgaatt ttctgatgat tagtgatact gagcatcttt taatatacat gttggtcatt   153720

tgcatgcctt cttaagttgc aggagttccc tatatatttt ggatattaac catttattag   153780

atatatagtt ggaaatattt tctcccattc tataggttgc tttttcaccc tcttgaatgc   153840

ttcctttttt tcccaaagct ttttagtttg atatggtctc aattgtctat ttttgctctt   153900

gtttgaattt tggagtcatt gccaagaaat cattgtcaag aacagtatca tgaagctttc   153960

ctgctatgtt ttcttctaca agttttacag ttttcaggtc ttaggtttaa atgtttaatc   154020

tattttgagt ttatttttgt gtatggtata atataagaat tcaattttat ttttttatat   154080

gtgaatatcc agttttccca acattatttg ttgagtggcc tcttttctat tgtgtattct   154140

tggcacccct gttgaatatg agttaactat ttatgcatgg gtttatttct gggctctcta   154200

tcctgtttca ttggcctata tatttgtttt atgccaggac catactattt taattgttgt   154260

agctttgtta tacattttga aatgaggacc tgtggggact gggtgcaatg gctcatgctt   154320

ataatcccag caactcggga ggctaaggct ggaggatcac ttgtggccaa gagtttgaga   154380

ccagcctggg caagatagac tccttcttta cgaagatatt tgaaaagtag ccaagcatga   154440

tggcacacac ctatagtcct agctacttag gagcctgagg tgggaggatc actgaagccc   154500

aagagtatga ggctgcagtg agctatgatc atgccactgc actctggcct gggcaacagg   154560

gtgagatctt ctctctcaat aaataaataa ataagaaatg agaaaatgtg attcttccat   154620

tttgttcttt tttcttaaga ttgctttggc tattcagagt cttttgtggt tccatatgaa   154680

ttttaggatc tttttttatt ttagtaaata atgctattgg gattttgata tgtactgtat   154740

tgaattcaca gatcacttag ggtagtatgg gcattttaac aatattaagt catttaattc   154800

gtgaatactg ggtctttcca tttatttgtg tcttctttaa tttccttcat gaacattttg   154860

tagttttcag tgcatacatt ttcaatgcct tggttaagca tatcctaagt attttatttc   154920

ttttgatgtt atcataaatg ggatttcttt cctaattttc tcttcagatt gtttattgtt   154980

agtgtataga aacgcaggtg atttttgtat gttgatttta tatccttcaa catctagtaa   155040

atttgtttat tagttctaac agattttcct gatgtgtgga gtctttaggg tactctccat   155100

ataaaataat gtcatctgta aacacttttt tctttcagat tgggatgtct tttacttgtt   155160

tttcttgcct aatttctctg gctaggactt ctagtgctgt gttaaataca agtggcaaga   155220

gtagccatat ttgtcttatt cctgatctta caggaaagtt tttcagtttt tcaccattga   155280

atacgatgtt agctgtggga ttttcaagta gtctttgtta tcatgaagta tatttcctct   155340

gttctcatcc atttgtgcta ctataacaga ataccacaga ctgggtaatt tataatgaac   155400

ataaacctta tgggatcaca gtactggagg atggaaagtt catgactgag gggctgtctg   155460

gtgaggtctt atttgttgtg tcataacatg ctgtaaggta tcatgttatg atacacatgg   155520

cacaaagaga gaataagtga gaaaaggagg cagaacctgc ctgtttataa tgaactcaat   155580

cctgagataa cagcattaat gcatttaaaa gggtaaaatt ctcataactt aaacacctct   155640

taaaggtctc acctcccaat tctgtcacaa ttgcaattaa attgcaacat gagctttgga   155700

ggggacaaac cttcaagtta tagcaacttc tatacctagc ttttgttttc tttttttagt   155760

ttttaccatg aaaggttgtt gaaatttgtc aaatgcttct tctgaatctc ttctgatgat   155820

catgtgattt ttatccttct cagatcatgt ggtgtatcac attattggtc tgcatatgtt   155880

gaaccatcct tgcatcctag ggacaactcc cacttggtcg tagtacatga tcatttaatg   155940

ggctgttgca ttcagtttgc taatattttg atgaagttat ttgcatctat gttcatcagg   156000

gatcttgttc tgtagtatgt ttttttctgt ttaaatattt gttcattttt aattgacaaa   156060

aattgtgctt atttatgggg tacaaaacaa tgttttgatc tacataaaca ttgtagaaat   156120

tttcagtcac gctaattaac ataaccatca cttcacccac ttatcatttt tttgtggtaa   156180

gaaagttaaa aagctattct tttagcaatt ttgaaatata catttatttt tttcatttcc   156240

tattgtgtga cttttttgac ttttatttta agttcagggg tacatgtaca ggatgtgcag   156300

tcttgttaca taggtaaaca tgtcataggg gtttgttgta cagattattt catccctgag   156360

gtattaatcc cagtatgcat tggttatttt tcctgaccct ctccttcctc ccacccttca   156420

ccctcccata ggccccagtg tgtgttgtta ccctttatgt gtccatgtgt tctcatcatt   156480

tagctcccac ttataagtga gaacatgtgg tatttggttt tctgttcctg ccttagttta   156540

ctaatgaaaa tggcctccag ctccattcat gtccctgcaa aggatatgat ctcgtttttt   156600

tttgaatggc tgcatagtat tatatggtat atatttacca cattatcttt atccagtcta   156660

tcactgatgg tcatttgagt tgattctatg tctttgccat tgtgaatagt gctccaataa   156720

acatatgtgt gcatgtgtct ttataataga aaaatgtatt tccctttagg tatataccca   156780

gtaatgggat tgctgggttg aatggcattt ctgtctttag gtctttgagg aattgccaca   156840

cagtcttcca ttatggttga attaatttac actcccatca acagtgtgta ggcattcttt   156900

ttttctccac accctcgcca gcatctgtta ttttttgact ttttcataat agccattctg   156960

actggtgtga gatggtatct cattgtggtt ttgatttgca tttctctaat ggtcagtgac   157020

attgagcttt ttttcatatg cttgtttgtt gcatgtgtgt cttcttttca gaagtgtctg   157080

ttcatatcct ttgcccactt tttaatgggg ttgtttattt cttgtaaact catttaagtt   157140

ccttatagat tctggatatt agacctttgt cagatgcata gtctgcaaaa attttctccc   157200

attctgtaga ctgtctgctt actctgttga tagtttcttt tgctgtgcag aagctcttta   157260

gtttaattag atcccatttg ttaatttttg tttttgttgc agttgctttt ggtgtcttca   157320

tcatgaaatc tttgcccatg cctatgtcct gaatggtatt gcctaggctg tcttccaggg   157380

tttttatagt tttagatttt acatttaagt ctttaatcca tcttaagatt tattcctcta   157440

ctctaaatga aaaatgtaca tcctttgatc aagatttata ctttctccac atcgtcttcc   157500

cccagtccta tggcaaccac ctttatatgc tgtttctgta atgttgactt ctcacttttt   157560

tattttttat ttatttattt ttttatttta ctttaagttc tagggtacat gtgcacaacg   157620

tgcaggtttg ttacatatgt atacatgtgc catgttggtg tgcggcaccc attaactcgt   157680

catttacatt aggtatatct cctaatgcta tccctccccc ctccccccac cccattttac   157740

atgtaagtga gatcatgtgg tatttgtctt tctgtacctg gctaattttg cttagcataa   157800

cgtcctttag tttcattcat gttgggatga atgacaaaat ttgttctttt aaagttttgt   157860

atagtagtgc actgtgcata cctatcacat tttctttatt cattcacctg ttgatgggta   157920

caggttgcat gtatgggtta gtgcaaaagt aattgcggtt ttggccatta cttttaattg   157980

cagcaaaagt aatggtaaaa actgcaatta catttgcacc aacctaatat gtcttggttc   158040

ttgtaaataa tgctgaaatg aacatgggag tgcaggtata cctttgacag aacgatttta   158100

attcctctaa aggaattaaa tatataccac tatataccta gaagtggaat tgctgaatta   158160

tatggtaatt gtatttgttt tgggaacttc catgctattt ttctcaaaca gctgtactaa   158220

tttacatttt cactaacaat gtataagggt tcctatttct ccacatcctc atcaacactt   158280

gttatcattc atctttttga taacagccat tctaggaggt gtgaggtaat atttcattgg   158340

gattttaatt tgcatttttc tgatgattag agatgttgag cattttttaa tatatctatt   158400

ggccattcat atctcttctt ttgagaaatg tctgttcaga ttatttgccc attctacaat   158460

tggtttattg attttctagg tgttgagttg cttgagcttt ttatgtataa tgttggatat   158520

tagcccttta tcagatgtat ggtttgcaga tattttattt caatccatga tctctctctc   158580

cactctgtta ttgcttcgtt tgctgtaaag aacattttta gtttgatcta atccaacttg   158640

tctcttattg tcttttgtta cctgtgcttt tagagtccta gccaagaaat ccttgcccag   158700

ataaatgtca tacagctttt cttttatgtt ttcttctagt agctttatag tttcatttct   158760

tatatttaag tcttttactt gtttggtttt ataaacatat ggtatgagaa agggcccaat   158820

ttcattcttt tgcataagga atattcagtt ttcccaacac catttattga agagatcgtc   158880

ctttccccca ttgtttattc tttgcacctt tgctgaaaat caattgacta taaataattg   158940

ggtttatttc tgggcttttt atccttttcc attagccaat atatctgtgt ttatgccaat   159000

agcatagctt tatattttga aatgacagag tattgcacct ctagctttgt tctttttgct   159060

cagattgctt tggccattta gcatcttttt tattttattc aaatgttagg attttttact   159120

atttctgtga aaactgacat tagaattttg atagggattg cattgaatct gtagattatt   159180

ttgggtagta tggacatttt aacaatatta attcttccaa cacatgaaca tgaaatatat   159240

tacaatttat ttgtgtcttc ctcagttttt ttaaatcaac ttatagtttt cagtgtacag   159300

atcttcaact ttcctggtta aatttacttc aaagtatttt atttatttat tttgatgctg   159360

ttttaaatag gattaatttc ttaatttctt tgttggatac ctcattgtta atgtatagaa   159420

atgctactga tttttctatg ttgattttgc aaactgcaac tttactgaat ttatgtatca   159480

gttttaacag ttctcagtag agtgttcagg gttttctaca tataaagatc atgtcattag   159540

caaacagaga taattttatt tcttgctttc ttacatggat gtattttatt tctttttcct   159600

gcctaattgc tatggatggg atttctagta ctatgtcaaa aagaagtggt aatagtcgat   159660

atccttgtct tgttcctgat cttagaagaa aagctcccaa cttttcagtt tttgcataat   159720

gttagccgtg ggcttgtcat atatggcttt attttgttaa ggtacattcc ttccatatct   159780

gctttgttga gattttatta tgaacatatg ctggatttta tcaaatgctt tgtctgcatc   159840

tagtaagatg atcatatgat ttttgttctt attttgttaa tgtagcatat cacatttatt   159900

gatttatgta tgtttaacca tttttgcatc cctcagataa atcccaagta atcatggtga   159960

atgatgtttt aaatgtgcta gggaattcag tttgctaata tattgttgtg aatttttgga   160020

tctatgttca tcaagaatat tggcctgcag ttttcttttc tggtagcata ctcttagggt   160080

tttcatatca gtataatact ggcctcataa aatgaatttg acctcctttt caattttttg   160140

gaagaatttg agaagaattc atattacttc tttaaataga attcaccagt gaccttttcc   160200

tttttttttt ttttggttag gagacttaat ttattactga tctattttct ttatccagta   160260

ttggtttgtt cagatgtaat atttcttgat ttagtcttgg taggttgcat gtttctaaag   160320

attagttcat tccttctagg ttattcaatt tgatggtgta tggttgttca cattaatagt   160380

ttatgattcc ttgtatttat gtgttatcag tgttagtctc ccttctttca tttcagatat   160440

tgtttgagtt gtcttttttc ccttggttag tctagttaaa ggtttttcga ttttatcttt   160500

tcaaaaaaac aactttttag tatttgcttt gtttatttct atcattatct ttgttatttt   160560

cttccttctg caaagtttgg ggatattctg ttcttctttt tctaatctct aagatgtaat   160620

attaggttgt ttatttgaga ttttccttct ttctttaatg taggcattta ttactataaa   160680

tttttctctc agggcttctt tttctacatt ccatactatt tgttatcttg tgtttccatt   160740

gtcattgatc ccaaaatatt ttctgttttt ccgtataatt tcttctttga cccattgcct   160800

gttcaggagc atgttgttta atttccacgt aattatgagt tgttcaaggt tattcttatt   160860

gacttctagt ttcatgtcat catgaacaga aaacatactc gatatgattt taatcttctt   160920

aaatttgtta aaacttgttt ggtggcctaa catgtgatct atcctggaga gtgtttcatg   160980

tgatttgaga agaatatgta ttttgttgct gttggatgaa ctgttctata aatatctgtt   161040

agatctattg gattaaagtg tagttcaagc cttcctctaa taagaaactg cataaattat   161100

gtcaggagca agccagggaa gaagccacct tcctgttctt ggtggtagag accttccaca   161160

tcttttaaaa gaaagattgt ggccgggcgc ggtggctcac gcctgtaatc ccagcacttt   161220

gggaggccga ggcgggcgga tcacgaggtc aggagatcga gaccatcctg gctaacacgg   161280

tgaaaccccg tctctactaa aaatacaaaa aattagccgg gcgtggtagc gggcgcctgt   161340

agtcccagct actcgggagg ctgaggcagg agaatggcat gaacccggga ggcggagctt   161400

gcagtgagcc gagattgcgc cactgcactc cagcctgggc gacagagcga gacagcgaga   161460

ctccatctca aaaaaaaaaa aaaaaaaaaa gaaagattgt agagttggga ttgtctctgg   161520

aggaagccag ggaagaaggc gtggggaatg ttattcctct tgtttaggct gaagaaggtt   161580

tattcttcat ttgctatgta gatttccaag tactggaaga ggccagaacc acagggagcg   161640

gctggaaaac gtgtagccta atggtttcca tggggaagtt ggaagatggt ctgatcccag   161700

gaattaaagc ttctgagagt gctcaggcag ttcaaaaccc cccatcgttt tttgtacttg   161760

agagaaaact ccaatggctt atctctgcca ttcctcaagc atggtgatct aaaagccaag   161820

ctctgtgtca gggcctataa aagttgggtt ctacaaaatg gaaaaccaag gcaattatga   161880

agatgatttt ataatatagt tcatctcttc tctctttaca ctctagaaaa agcattttct   161940

agaaataaat acatttcctt aaattaaaaa aaagttgggt tctatatgtg tgctatagtt   162000

tctcaaccct tgggaagtag ctgcaaattt ggttttcttc ccaaatgtaa ggcactgtgc   162060

tcagggtggg gttagtgcat gagtgtcttt ccactttttc tacccatttt gatatgggta   162120

ttttctgtcc tctggtgtgc atgagttttt ctactggatt ctgggtttct ctggagagaa   162180

ctgatccatg tgtatgtaga tgtttacttg gtacgtccat gagagaaaaa atagtcataa   162240

acctcctatt ccacaatgtt gctgaagtca cttccttcaa aagctgtaat tttcttttct   162300

tacagtgtct ttgtctggct ttgatatgag aataattctg gccccataaa atgactttcg   162360

aagtgttctt tcctcttcaa agttttaaga gagtttgaga agaattaatg ttgtttcttc   162420

tttaaatgtt tggttggact tctccagaga agccgtctgg tcctgtacat ttcttttttg   162480

ggagttacta tcattatcat tattattatt attattatta ttattattat tattggttca   162540

atttgtctat tcagttattc tatttcctca tgattcagtc ttggtaggtt gtatattttt   162600

ggaatttacc tattccttct aagttatcca atttgttggt gtataattgt tcatggtagt   162660

ctctttgatc cttcttattc ccataaaatc agttgtaaat tctcctcttt catttctggt   162720

tttacatatt tgagtcctct atcttttttc ttagttatgc ttgctaagga tttgtctatt   162780

ttatctttcg aaaaaaccaa ttcttagttt tgttgacttt ttctattgct tttttattct   162840

ctatttcact tacttagctc taatacttat tatttccttc cttttgctga tgttgggctt   162900

agtttgttct ttttctagtt cctagacatg taaatctata ttgtttatat gagatatttc   162960

tttttataat gtagacatgt atctcaataa gatttgcttt tattactgct tttgctgcat   163020

ctcataaatt ttggaaattg tgctttcatt tttgtttgtt tcaagatact tttaaatttt   163080

cctattgatt ttttttcttt gacccattgc tttttcaaga gagtgttgtt taatttccac   163140

atatttgtga atttttcagt tttccttcta ttactgactt ccagtttcct tccattgtgg   163200

tcataaaaga tatctggtat gatttcaact tcttaacagt tgtcaaaaca aacttcatga   163260

cctgatatgt gatctatcct gagaatattc tgtgcgcact tgaaaagatg gtatattaag   163320

atgctgttgg gtagcatatt ctgtgtgttt gtgatccatt tggtctatag cgttgttcaa   163380

atccacagtt tgtttataga ttccatatct ggctgttctg ttcattattg caagtcgggt   163440

attgatgtat cctactgtta tggtgttgct gcatgtttat cccttcagat ctgtcaatga   163500

ttgctttacg tatttacatg ctttgatgat ggattcacat atatttataa ttgttatatc   163560

ttcttgatga attaactctt ttatcttatt ttatgaccta ctttgtctct tgtgacagtt   163620

ttttatttaa aatctatttt ggctgatata attacagggt gtcctctgtg tctgtgggtt   163680

ttacatctgt agattcagcc aatgctgatt gaaaacactg tattcatgga atgtgaaatc   163740

cacagataca gagggtcaaa tttttttatc cacaggtcct gcaagactga ctgtgggact   163800

taagcatcct caattttggt atcccttggg gttctgaaac catgaccctg tagatactga   163860

aggacgactg tatagcccca ttgctctctt ttggttacca tttctacaaa atgtatcttt   163920

tttatcaatt aactttcaaa ctatgttttc ttaaatctga aacgagtatc tggagacagc   163980

atataactgg atcttgtttt cataaatcta tgcagccatt gtaggtcttt tgattgggaa   164040

gtttaatcca tttgtatttg aaataatcat tggtaggtaa tgacttacta ttgccttttt   164100

gttaaatttt tctgttttgt aattcttttt ttctgtcttt ttctctctta actgtcttct   164160

tttgtgattg gatgatattt tattgtgata tgctatgatt tctctttttt atttctgtat   164220

ttttacgtgg attttccttg tggttatcat gaggcaatca caaatatctt ataatagtct   164280

actttaagct gataacaact taacttcaat catatatcaa aaatcttcac ttttaatacc   164340

tccctcacac tttttgttat gtcacaattt acatcttttt ataatgtgtt tctacaaaca   164400

catttttgta attttagtta ttcttaatta ttttgacatt taacttttat attagaatta   164460

taaatgattt atataatact attagagtat tacagtattc tctatttgtc catgtattta   164520

cctttactag tgagatttgt gctttcatat gctcttgtgt tgctctttac catgctttcg   164580

tttcaacttg aagaactcac tttagcattt cctataagat aaatctagtg gtgatgaact   164640

ccctcagcat ttgcttgtat gagaaagttt ttatccttcc ttaattttaa aggacagttt   164700

ttccaggtat attattcttg gtcagcagtt tttttcttta agtattttga atatatactt   164760

tcactttatt tgctctttta aagtttccac tgagaaatct gctgttcatc ttaagagagc   164820

tcttttggac atgacaattc agtttttttc ttgctgcttt caaacttccc tttcactttt   164880

ggcaatttga tgatattatg tctctagtgg agactttctt tctttttttt ccgagataga   164940

gtttcaccgt gttgcccagg ctggagtgca gtagcatgat cttggctcac tgcaacttcc   165000

acctcgtggg ttcaagcaat tctctctgcc tcagcctccc gagtagctgg gattataggc   165060

acccaccacc acacccagct gatttttgta atttttggta gagatgtggt tttgccatgt   165120

tggccaggct ggtcttgaac tcctgacctc aggtgatcca ctcccgctca gcccctcaaa   165180

gtgctgggat tacaggtgtg agccaccatg cccagccgag acttctttag atttgtccta   165240

tttgggattc tttgagtttc ctgaatttag atgttcatat ctctccccaa atttgaacat   165300

attttagtca tttaaaaaat atttttacac ccctttctgt cttctctgtg atttcataat   165360

gcatatattg ttccacttaa tgatgtccca tgaaccttca ctcatttttt tttttatttc   165420

ttcttgctcc actgactgga taattttaaa tgatctacct tttttttttt ttttggtgtc   165480

catcttttga gggtttttta attttatttt ttattttttt atttttattt tttattatac   165540

tttaagtttt agggtacatg tgcacaacgt gcaggttagt tacatatgta tacatgtgcc   165600

atgttggtgt gctacaccca ttaactcatc atttaacatt aggtatatct cctaatgtta   165660

ggtatatccc cctcctcccc ccaccccaca acaggccctg gtgtgtgatg gtccccttcc   165720

tgtgtccatg tgttctcatt gttcaattcc cacctatgag tgagaaagtg cagtgtttgg   165780

tttttttcct tgcgatagtt tgctgagaat gatggtttcc agcttcatgc atgtccctgc   165840

aaaggacttg agctcatcct tttttatggc tgcatagtat tccatggtgt atatgtgcca   165900

tattttctta atccagtcta tcattgttgg acatttggct tggttccaag tctttgctat   165960

tgtgaatagt gccgcaataa acatacgtgt gcatgcgtct ttatagcagc atgatttata   166020

atcctttggg tatataccca gtcatgggat ggctgggtca aatggtattt ctagttctag   166080

atccttgagg aatcgccaca cggacttcca cagtggttga actagtttac agtcccacca   166140

acagtgtaaa agtgttccta tttctccaca tcctctccag cacctgttgt ttcctgactt   166200

tttaatgatc accattctaa ctggtatgag atggtatctc attgcggttt tgatttgcat   166260

ttctctgatg gccagtgatg atgagcattt tttcatgtgt tttttggctg cataaatgtc   166320

ttcttttgag aagtgtctgt tcatatcctt tacccagttt ttgatggggt tgtttttttc   166380

ttggtttgtt gattctttct ccagtttgat caagtctgct attgaatcct ctagggagtt   166440

ttttagttca attattgtat tcttcaattc cagagttttt actgatattt gactttttgt   166500

gtgtgtgtgt atagtttctt tcccttcatt gatatcctca ttgtgttcat gtatcatctt   166560

cctgattttg tttagttgtc tatctctgtt ctctggtact ttgctaaact tcattaggat   166620

aattattttg aattcttttt taggcaattt ataaatctct atttctttag ggtcagtaac   166680

tgcggatttc ttttatccct ttttgttgtt tccctaattc tttgtgttcc ttgtgctttg   166740

cattggtgtc tgtgcattgg aagaatagcc acctgtcagc catccgacac aatgtcacaa   166800

aggacacaaa acagccacca agatttatgg actgactttg acagggcaag acctttgcca   166860

gtcagcctgg ctagagatac tgagagtctc tcaaacagct aatctaccgt ccccttttcc   166920

tatgtttgta gctgtatcaa ttgttctaat catactggtt ctttcagtgc tccatatgag   166980

gcaagagtga aactggaccc tagtgcagca cactgaatgg caaggacatt tgatgtgctc   167040

cactcctctc cctcccttga aagtggtatc ttgatgaaaa tgaataaatt agcccctaga   167100

aaggatggat aaattgtttc aaaccaagta acaggatacc agcacagtta tgattgaaat   167160

gcctgtttga tttgaaaacc catatctttt ccacaatgca atgttgccac ttactgcttt   167220

ttaacttcaa taatttgatc aaagcttatg gctctatcaa ctacccatgc ctctttctaa   167280

taaccaaccc tattttacta gtttttccaa ctattcatca tcctcataag tacttttttc   167340

acctctaatg atttcatgtg aaattagttt ttaataatca taaaacatac tactattaga   167400

acaaaagtca ttaatgagtt caagttataa aaaggaagat tacatgatat acaaatatat   167460

aattacaaat ttgagcaact atggagtaaa tgttaacaat aacctcattt cattaactct   167520

catcttatca ggaagtttaa tagcaccaac agtaatagta actaaaattt aatgaagact   167580

taccatgtgc cagatattat gctaagtatt cttcatgcat tacctcaatt tatcttctca   167640

gcaaacacaa atgcagtgac tactcttata atgatgaggt ggttttactt aaagaattaa   167700

gaaacttacc caaggacaaa agaaaggact tgaacaaaga tgatctgaca ccagaagtga   167760

agaagtcttt attactatgt aatacagcct caatgtagat tgtaacacag aaaaaaacta   167820

gcctgactta cagaattcct tccacctagg ttttaaaggg atacattttg cacaaggcct   167880

aaataagcta taggaaaaca aaacacccac gcaagtttct ctattgaatt aattcataat   167940

ctcctattag ttttatccca ttcttcatca tattgacaac caggatatca ttaggggaaa   168000

acaaaatcta ttactttgat tttctcttca aagttggagt tttctcctca gtttttctcc   168060

agcttcttct gtcaagttct tggcatgctg taattttcag tccccattaa tgaacagtaa   168120

aggatctggg tttctcttga cattgacatg aagtctgtct ctctcatgcc ttgccagtag   168180

gtgagatgaa tatgaaaatt acataaagac tgcatattaa atagaggaaa gctgaattaa   168240

aacactctaa ggtggccgga tatggtggct cacgcctgta atcccagcac tttgggaggc   168300

caaggctggc agatcacttg aggccaggag ttcaaaacca gaccagccaa catggtgaaa   168360

ccctgtctct actaaaaata caaaaattag cctgatgtgg tggcatgcac ctgtaatccc   168420

agctacttgg gaggctgaga catgagaatt acttgaaccc aggaggtgga ggttgcagtg   168480

agccaagatg gtggcactgc actccagcct gtgcctcaga gcaagactcc atcaaaaaca   168540

acaacaacaa caacaacaac aacaaaaaca ctctaaggca gaaagggaag tctggttacc   168600

attaggtgtt tgatgaataa gaaaattcaa tataatggga agcttcccat tcaatagcaa   168660

acaattaaaa aaataagtaa ataagaggaa gctgaatatt accaaatcca agagaataaa   168720

gggaaaccat aaccaggtca tctttaattc cagcacccta caagttaagt aatgatctca   168780

gaactataaa tccttgaaaa taaattctta attatatgga ttatactaat ttatgctgtg   168840

acttaaaaag gtgaaattat agactaatgt agaatataca taaatctgta aaacttacag   168900

ctaacttaag aaattagcag agaacaaagg gagcaactga agcttctagc ccccctttgt   168960

aagatttagg cttttccagt caaaaacctc atttagatgt tatgttattt actgttgaat   169020

tttaaaagtt atattttctt ttatgtaatc aattggaaag tccttcagtt tgggtatgat   169080

aattgataac ttcctcagta cctagaaatc tatcaaggat aatgttgaca tccaataaag   169140

tgtttatgtt gaaatccttt atttagaatt aaaaaggtag tcaaagagtt tcttgaaata   169200

gagatataga aatgtatatt atcattttag tttatattca ttttttatgt aaaggaataa   169260

tggtatatta aaatgaatat aaaattaata caattttggt tattgtatgt agcccctatt   169320

ctttttttat tattatactt taagttctag ggtacatgtg caaaacatgc aggtttgtta   169380

cataggtata catgtaccat gttggtttgc tgcaccaatc aactcatcat ttacattagg   169440

tatttctcct aagtaatccc tcccaaagct cccaaccccc taactgcccc tggtgtgtga   169500

tgttcccctc cctgtgtcca tgtgttctca ttgttcaact cccacttatg agtgagaaca   169560

tgcagagttt ggttttccgt ccttgtgata ttttgctgag aatgatggtt tccagcttca   169620

tgcatgtccc tacaaaggac atgaactcat ccttttttat ggctgcatag tattccatgg   169680

tgtatatatg ccacattttc tttatccagt ctattattga tggacatttg ggttggttcc   169740

aagtctttgc tattgtgaat agtgctgcaa taaatataca tatgcatgtg tctttatagt   169800

agcatgattt acaatccctt gagtatatac ccagtaatga gattgctggg tcaaatggta   169860

tttctagttt tagattcttg aggaatcatc acactgtctt ccacaatggt tgaactattt   169920

tacactctca ccaacagtgt aaaagcgttg ctatttctcc acatcctctc caacatctgt   169980

tgtttcctga ctttttagtg attgccattc taattggcat gaggtggtat ctcattgtgg   170040

ttttgatttg tgtttctctg atgaccagtg atgatgagca ttttttcata tgtctgttgg   170100

ctgcataaat gtcttctttt gagaagtacc tgttcatatc ctttgcccac tttttgatgg   170160

agttgtttgt ttttttcttg taaatttgtt taagttcttt gtagattctg gatattagcc   170220

cttttgtcag atggataaat tgcaaaaatt ttctcccatt ctgtaggttg cctgttcact   170280

ctgatgatag tttcttttgc tttgcagaag ctctttagtt taattagatc ccatttgtct   170340

gttttggctt ttgttgccat tgcttttggt gttttagtca tgaagtcttt gcccatgcct   170400

atgtcctgaa tgatattgcc tagagtttct tctagggttt ttatggtttt aggtcttaca   170460

tttaagtctt taatccatct tgagttaatt tttgtacaag gtgtaaggaa gggatccagt   170520

ttcaactttc tacatatggc tagccagttt tcccagcatc atttattaaa tagggaagcc   170580

tttccccgtt gcttgttttt gtgaggtttg tcaaggatca gatggttgta gatgtgtagt   170640

gttatttctg aggcctctgt tctgttctgt tggtgtatgt atctgttttg gtaccagtac   170700

catgctgttt tggttactgt agccttgtag tatagtttga agtcaggtag tgtgacgcct   170760

ccagctttgt tctttttgct taggattatc ttggctatgc aggctctttt ttggttccat   170820

atgaacttta aagtagtttt tttccaattt tgtgaagaaa gtcagtggta gcttgatggg   170880

gatagcattg aatttataaa ttaccttggg cagtaatgcc attttcatga tattgagtct   170940

tcctatccat gagcatggaa tattcttcca tttgtttgtg tcctctttta tttcgctgag   171000

cagtggtttg tagttctcct tgaagaggtc cttcacatcc cttgtaagtt ggattcctag   171060

gtattttatt ctctttgtag taattgtgaa tgggagttca ctcatgattt ggctccctat   171120

tctttataaa agttctaaat atttgccaaa tcatcaaaga agatattcat tacttttaat   171180

tcttacaaat tttcttagca ataaaagtca cagtaagaca gctagcagat aaaaaagata   171240

aaagtacata gtttaaaaca acactgatta gcacaccaaa agaatattga gccaatcctt   171300

attatatgta atacaaatat ttatatatgc acatttaact gtgtttggag acccatgttt   171360

ctacacatat gtaattattt aagatatatt ttatgtatag ctatcatgaa cataataaaa   171420

tacattttat ttctatatta acacatttta acctatttta gtaatctata gaaagatgta   171480

gacaatgatt ctggttttaa ctacatttat tttttgtttg tttctttacc ttggaggtca   171540

agacatcttt atgacagaag aacagaagaa atactataat gcaatgaaaa agctggggtc   171600

caagaagcca caaaagccaa ttcctcgacc aggggtaaaa aaatatatat atctttagca   171660

tatagatttt caaattattt ctaattcatt tttaatgcac atctttaatt tctggataat   171720

acttgaaaag tttactctgc attcgatatt attcttattt ctttgcagaa caaaatccaa   171780

ggatgtatat ttgacctagt gacaaatcaa gcctttgata ttagtatcat ggttcttatc   171840

tgtctcaaca tggtaaccat gatggtagaa aaggagggtc aaagtcaaca tatgactgaa   171900

gttttatatt ggataaatgt ggtttttata atccttttca ctggagaatg tgtgctaaaa   171960

ctgatctccc tcagacacta ctacttcact gtaggatgga atatttttga ttttgtggtt   172020

gtgattatct ccattgtagg taagaatatt tatttttcag attttatttt ttgagtaaag   172080

ctaaacttca cttatgctca aggaagtata tgctgaattc ttgaacacaa atttactctt   172140

gagtaagtca gtacaatgaa agaatgaaaa aatcctaaaa agcaaaacaa atatctgtct   172200

ctcatactac agtgtttctg ggtttacact acaggcccca aagccaaata tttctatcta   172260

ttagaaggaa attatacttg ttgatattta gtttccaata ttacctttgc aaaactagtt   172320

accatgttta tatatagctg tgtcttggaa aaccaatgtt gaatctgaaa taacttctgg   172380

ttttagcaca tgtgagactt gtcatttgat taatgataat attaatagcc agaatatctg   172440

tgaatttgtg aaaattcttc cagaatttaa agtgaagtta agatctctag aaatgccagt   172500

tttatttttt acagcttaat acttcacaag tgtataaaat gccaatcatt cctcaaccag   172560

ccatggtgtt catgtctgtg aataacagca catgatttta tacttcctat acattcattg   172620

ccatggttgt ttttctatct tcttgttttt gttgttgttg ttattttcac atatcttgca   172680

aagtatttta ggattgtatt tctttttaga attataaact tttaagagag agagattata   172740

gagattacta caagtttaat caacaggtta tcaatctgaa aaggttcaag gttgcatgac   172800

ttagaatcat aaaattgagt gccacataac agagtaagca tttaaaatca ataattttgg   172860

aaaagcatat tatcaccaga agtcatacca aaattgatat aagaaaatgt attaaaattt   172920

aggtgagaat ttcacactaa caaaaatgat tctgaaagca ttcctattaa gtcaggaaaa   172980

aaaaaagagt gtgcctgtat catccctgtt tttagtgttg ttggccaatg caattagata   173040

agaaaacaga gaggtacata tataaaaaca atggagtaaa tgatccttaa tataatgacc   173100

ttcttcatat aatgaaagaa cttgttcata tattgaaaga gaatcaacta aaaataaatt   173160

caattagagt tcaaaaggta caaattttaa attacatgtg ccaacactaa taattatctt   173220

atacatgaaa aaaattagaa aatctgattc acaattgcaa taaaaataaa gtaaattatc   173280

taataataac tttatcatat gagacttctg aagaaaactt taggatataa aagaaagcta   173340

aaataattga aaggattgtc atgtacttag ataagcttct ctcattgtaa ttaagacttt   173400

caaatttatt aatctataaa ttcaaggaaa atatcaatga gtctttttat gtagtgtggg   173460

taataaatag acaaaaacaa tataagtcta aatgattcta aattcatctg gaagaaaatt   173520

agggtgacaa gaggtggctt attctgcaaa atattaagac atatagatgt taaataaaac   173580

tgttcaaata taaaagctca gtgggtttga agagagtcca aattaaactt taatgtataa   173640

ttaccaattt actgtgtgaa aagatcacat gaatcaaaat ctaaagttaa aaaaaaagat   173700

tctagtagga aatatgtgga aatagacata taaccatata ctcttatagt cctttctatg   173760

caaaacacaa atttgtaaag ccaaaaaaaa aaatgaagaa gaaatgactg cacaaaaaaa   173820

caaaatattc tttggggaaa aaatcatcat aaataaaagg ttgaaagaca aaaaataggt   173880

gaaatgttta cataacagtt aaggccgaga aaggatcaat actttaaata gaaaattgtt   173940

cttataaatt aataagaata tagtaaaaat cccaatagac acatgggcaa ataccaaact   174000

aagccaaaaa cagaagttaa aaacaaccaa taaggataca aaataacaaa acacaaggaa   174060

aattgtggat tattttcaca aaaaatgcaa ataaattaca atagtagatg ttttcaaatg   174120

tcatgaaaat tttttggtaa aaaactataa agaagaatgg tagcactcaa tactgttgaa   174180

tgtgtaaagt atgagcacta tcatatactg ccattagaaa tgttaattag tacaggcttt   174240

ctggagatag gttcagctat atattgtgtg tatatatata cacatacaca cacatactat   174300

gtatatagta tagagtatgt atatatgtat actatatata tacatactct atactatata   174360

tatagtatac gcatactcta tactatatat atagtatacg catactctat actatatata   174420

tagtatacgc atactctata ctatatatat agtatacgca tactctatac tatatatata   174480

gtatacgcat actctatact atatatatag tatacgcata ctctatacta tatatatagt   174540

atacgcatac tctatactat atatagtata tgcatactat atgctatata gcgtatatgc   174600

atactatatg ctatatagag tatacgcata ctatatgcta tatatacata ctatatagta   174660

tacatatact atgtactgta tatacgtata cttagtatat gtatatgtat atgtatagta   174720

tatgtatatg tatagtatat gtatactata tactgtatat agtatatata gtatgtgtat   174780

atatatagta tgtgtgtata tatagtgtgt gtatatatat aaacatatat atactgttga   174840

cccaagttct attaacatat tattaaaaag tactcatgca attaggagaa catagctatt   174900

tagatattca tttcagtaac aaaaatggaa acagtataaa tgctagtctt caatttgtgg   174960

ttattttgag agaacattat accactataa taaattattt cgttgtcatt tttatgaaac   175020

tatctccatg acatataaag taaataaaat aggttacagg ctgggcactg tggctcacgc   175080

ctataatccc agcacattgg gaggccgagg tgggcgaaat cacttgaagt cagaagtttg   175140

agaccagcct ggccaacaag gtgaaaaccg tccctaccaa aaacacaaaa attaaccagg   175200

tgtggtggcg catgcctgta gtcccagcta ctctggaggc tgaggctgga gaatcatttg   175260

atcccgggat gcagagattg cagtaggcca agatcacacc accgcactcc agctttggcg   175320

acagagcaag actctgtctt gaaaaataaa taaataggtt acaaaaaaag cttatataac   175380

atgaatacat ttgtttgtgt gtgtacatgt gcttgcacag aaaaatgtct gaagtgatac   175440

tcaaaaaaat attgataata gttattgttg acatttcagg tgatttatat tttcttttta   175500

gcatttaacg gtattgcttg aattttctat gtgagtaggt atcattctta aaatgtaaaa   175560

cactattatg gagggaaaaa atggcccatg aacttagtaa aaaggagaaa atgtcacaat   175620

ggtaatgtta gtcatttctc tttggaattt cttaatcctt ttttaagtaa ttgcattcag   175680

tataaaataa ctgtcttggc cgggcacggt ggctcacgcc tgtaatccca gcactttggg   175740

aggccgaggc gggcggatca cgaggtcagg agatcgagac catcctggct aacaaggtga   175800

aaccccgtct ctactaaaaa tacaaaaaat tagccgggcg tggtagcggg cgcctgtagt   175860

cccagctact cgggaggctg aggcaggaga atggcgtgaa cccgggaggc ggagcttgca   175920

gtgagccgag atcgcgccac tgcactccag cctgggcgac agagcgagac tccgtctcaa   175980

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaact gtcttgaatt cataagaaat   176040

gagttgacag ataaaactgt ttagagtcat catttcaggt agcatacatc tttaaatatt   176100

ttatttctat tattttcctc cacatacagg tatgtttcta gctgatttga ttgaaacgta   176160

ttttgtgtcc cctaccctgt tccgagtgat ccgtcttgcc aggattggcc gaatcctacg   176220

tctagtcaaa ggagcaaagg ggatccgcac gctgctcttt gctttgatga tgtcccttcc   176280

tgcgttgttt aacatcggcc tcctgctctt cctggtcatg ttcatctacg ccatctttgg   176340

aatgtccaac tttgcctatg ttaaaaagga agatggaatt aatgacatgt tcaattttga   176400

gacctttggc aacagtatga tttgcctgtt ccaaattaca acctctgctg gctgggatgg   176460

attgctagca cctattctta acagtaagcc acccgactgt gacccaaaaa aagttcatcc   176520

tggaagttca gttgaaggag actgtggtaa cccatctgtt ggaatattct actttgttag   176580

ttatatcatc atatccttcc tggttgtggt gaacatgtac attgcagtca tactggagaa   176640

ttttagtgtt gccactgaag aaagtactga acctctgagt gaggatgact ttgagatgtt   176700

ctatgaggtt tgggagaagt ttgatcccga tgcgacccag tttatagagt tctctaaact   176760

ctctgatttt gcagctgccc tggatcctcc tcttctcata gcaaaaccca acaaagtcca   176820

gctcattgcc atggatctgc ccatggttag tggtgaccgg atccattgtc ttgacatctt   176880

atttgctttt acaaagcgtg ttttgggtga gagtggggag atggattctc ttcgttcaca   176940

gatggaagaa aggttcatgt ctgcaaatcc ttccaaagtg tcctatgaac ccatcacaac   177000

cacactaaaa cggaaacaag aggatgtgtc tgctactgtc attcagcgtg cttatagacg   177060

ttaccgctta aggcaaaatg tcaaaaatat atcaagtata tacataaaag atggagacag   177120

agatgatgat ttactcaata aaaaagatat ggcttttgat aatgttaatg agaactcaag   177180

tccagaaaaa acagatgcca cttcatccac cacctctcca ccttcatatg atagtgtaac   177240

aaagccagac aaagagaaat atgaacaaga cagaacagaa aaggaagaca aagggaaaga   177300

cagcaaggaa agcaaaaaat agagcttcat ttttgatata ttgtttacag cctgtgaaag   177360

tgatttattt gtgttaataa aactcttttg aggaagtcta tgccaaaatc ctttttatca   177420

aaatattctc gaaggcagtg cagtcactaa ctctgatttc ctaagaaagg tgggcagcat   177480

tagcagatgg ttatttttgc actgatgatt ctttaagaat cgtaagagaa ctctgtagga   177540

attattgatt atagcataca aaagtgattc agttttttgg tttttaataa atcagaagac   177600

catgtagaaa acttttacat ctgccttgtc atcttttcac aggattgtaa ttagtcttgt   177660

ttcccatgta aataaacaac acacgcatac agaaaaatct attatttatc tattatttgg   177720

aaatcaacaa aagtatttgc cttggctttg caatgaaatg cttgatagaa gtaatggaca   177780

ttagttatga atgtttagtt aaaatgcatt attagggagc ttgacttttt atcaatgtac   177840

agaggttatt ctatattttg aggtgcttaa atttattcta cattgcatca gaaccaattt   177900

atatgtgcct ataaaatgcc atgggattaa aaatatatgt aggctattca tttctacaaa   177960

tgtttttcat tcatcttgac tcacatgcca acaaggataa gacttacctt tagagtattg   178020

tgtttcatag cctttcttct ttcatatccc tttttgttca tagaataacc acagaacttg   178080

aaaaattatt ctaagtacat attacactcc tcaaaaaaaa caaagataac tgagaaaaaa   178140

gttattgaca gaagttctat ttgctattat ttacatagcc taacatttga ctgtgctgcc   178200

caaaatactg ataatagtct cttaaactct tttgtcaaat tttcctgctt tcttatgcag   178260

tattgtttag tcatcctttc gctgtaagca aagttgatga aatccttcct gatatgcagt   178320

tagttgtttg accacggtac atacttgagc agataataac ttgggcacag tatttattgc   178380

atcacttgta tacaatcccg tgtttggcaa gctttcaaat catgtaatat gacagacttt   178440

acacagatat gtgtttagta tgaataaaaa agcattgaaa tagggattct tgccaacttg   178500

ctctcttgcc accaacttac tttcctaaat tatggaagta atcttttttg gatatacttc   178560

aatgtataca atgaggaaga tgtcaccttc tccttaaaat tctatgatgt gaaatatatt   178620

ttgcctcaat caacacagta ccatgggctt ctaatttatc aagcacatat tcattttgca   178680

ttagctgtag acatctagtt ttttgaaaac acctattaat agtaatttga aaagaaataa   178740

ccataatgct ttttttcgtg agtttatttc aggaatatga gatctttctt ctataaagtt   178800

attcatgcac aggcaaaaat tgagctacac aggtagaatg tagttttact tagaagattt   178860

ttgtgggagg ttttgaagca aatatataaa acaactttca ctaatttgct ttccatattt   178920

aaaaaataat aaattacatt tatataataa atgtttaaag cacatatttt ttgttgttct   178980

ggcaatttaa aaagaaagag gatttaaacg tacctataga aacaaagatt tatggttaaa   179040

gaatgagatc agaagtctag aatgttttta aattgtgata tattttacaa catccgttat   179100

tactttgaga catttgtcct aatctacgta taaaactcaa tctagggcta aagattcttt   179160

ataccatctt aggttcattc atcttaggct atttgaacca ctttttaatt taatatgaaa   179220

gacaccatgc agtgttttcc gagactacat agatcatttt atcacatacc taccaagcct   179280

gttggaaata ggttttgata atttaagtag ggacctatac aaaatatatt acatttatca   179340

gatttttaaa tacattcaat taagaattta acatcacctt aaatttgaat tcaatctacc   179400

gttatttcaa actcacaaat ataactgcat tatgaatact tacataatgt agtaagacaa   179460

gatgtttgac aggttcgtgt gtaattttct attaatgttt ttacattgcc ttgtttttat   179520

gtaaaataaa aaatatgggc aactggtttg ttaacaacac aatttcttct tagcatttca   179580

aaaatatata taaagttgtt ctttttccta tttcatgaac tatgtttttt tttaaaataa   179640

catggttaag ttttatatat atttacgttt gtttcaggaa tgtctacttg tgacttttta   179700

tcaattaaaa ataatatttg gaagaaagag cttattaagt ataagcttga agtaaaatta   179760

gacctctctt tccatgtaga ttactgtttg tactgatggt ttcacccttc agaaggcact   179820

gtcatattaa tatttaaatt ttataatcgc tgaacttatt acacccaaca atacagaaag   179880

gcagttacac tgaagaactt aacttagaat aaaatggaag caaacaggtt ttctaaaaac   179940

ttttttaagt gaccaggtct cgctctgtca cccaggctag agtgcaatgg catgatcata   180000

gctctctgca gcctcaactc tgggctcaag caaccctcct gcctcagcct cccaagtagc   180060

taagactaca ggtacatgcc accatgcctg gctaatattt aaatttttgt agataagggg   180120

tcttgctatg ttgcccaggc tagtctcaaa ctcctggctt caagtgttcc tactgtcatg   180180

acctgccaac atgctggggt tacaggcatg agccaccatg ccccaaacag gtttgaacac   180240

aaatctttcg gatgaaaatt agagaaccta attttagctt tttgatagtt acctagtttg   180300

caaaagattt gggtgacttg tgagctgttt ttaaatgctg attgttgaac atcacaaccc   180360

aaaatactta gcatgatttt atagagtttt gatagcttta ttaaaaagag tgaaaataaa   180420

atgcatatgt aaataaagca gttctaaata gctatttcag agaaatgtta atagaagtgc   180480

tgaaagaagg gccaactaaa ttaggatggc cagggaattg gcctgggttt aggacctatg   180540

tatgaaggcc accaattttt taaaaatatc tgtggtttat tatgttatta tcttcttgag   180600

gaaaacaatc aagaattgct tcatgaaaat aaataaatag ccatgaatat cataaagctg   180660

tttacatagg attctttaca aatttcatag atctatgaat gctcaaaatg tttgagtttg   180720

ccataaatta tattgtagtt atattgtagt tatacttgag actgacacat tgtaatataa   180780

tctaagaata aaagttatac aaaataaaa                                     180809


<210> 5304
<211> 190794
<212> DNA
<213> Homo sapiens

<400> 5304
taggataaat ccagagcaac gttagttaaa gttaattcag ccccactgct aagataagac       60

ccttctgcag agtctaccca atatctcctg tgttttgagg tcttttcact ttgactgggg      120

aggataaaat attactatcc ctgtgtgagg tccaagaatt tttaacctgc tacttaagat      180

tacagtcatg tcagtcatgt gccagataac acttcagtca aggacagact gcatatatga      240

tggtggtccc acagattata atactgtatt tttactgtaa cttttctatg tttaggtatg      300

attagacaca aaaataccac tgtgttacaa ttgtctcagt acagtaacat gttgtacagg      360

tttatagcct agaagcaata ggctatacca taaagactaa gtatgtagta gactatacca      420

tctaggtttg tgtaagtact gtctctatga tgttaaaatt gcctagtgac acatttctcg      480

gtacatatct ccattgttag gcaatgcatg actgtagttc tttctctggc ttagggtatt      540

tttgttttca cacaattgca gaatgctgtc aagcaaaaac ttgaggtctc tttctacaga      600

tctctggtat actctctgtt cagctccctt gtcttaggtg tcctgtccca aataaacaaa      660

ttctagctcc ctcagcctat caaactctta ttttctggct cttcatgttt ccatcttcct      720

gagctgtggt ttagaaactt tgtgtagtat gcagagacaa tcacagcctc actttctttc      780

tcttctctag ggatcactgt cttatagata atgttgccca atgactgaaa actagtgttt      840

catatatttt gtccccttat ctaatggaag acttctacaa gggaatgtcg ataacaatag      900

ttttgatcaa aaataactcc acagaaagca cattatcagc aaaaccattg ttagggtaag      960

ggacccatca gtggactatg acactgggga aaattcttca ggaataagta atcaattaat     1020

atacttacta agcatctact acatgcaaga caaaacattt atttttcttc acatcagttt     1080

tctggccaaa aaaatccaga ccacgtcaaa ttagacgagc aaacactcag atgccaatac     1140

atttaggaaa cctcttttct tcagttgttt cattaagcat catttgccca tctcatcact     1200

ccaatctatg tctgataatc ttcattgtat attctatttc tttttagtta taatttgaag     1260

ttctactttt gaatcctact ttttagctat gtatacacaa aacttgtaac tttattcttc     1320

tattttcaca acagaataat tgttttttct tactttgtaa tattgccgtg cagccaatat     1380

tagaaggtaa aagtattttt ctaatcctat ttaattagag aaaaacaaac tctttcagta     1440

ttgtattaat tttattgcct taatattact gtctattttt tgttcttcca gaaacttcta     1500

cagttttgaa aattgcagtg gcaattgtgg aaaatacaga agtgtggata tccatttatt     1560

tctcactaag ggaaataaaa ttcttattcc tattctggta tggattgtat gatgttagtt     1620

aatttccatg actcaacatt tccacatttt tctatctaag ttacggaagg tcagttgtaa     1680

atatgattag gaacttattg gttattggct ttttcaacca gacaggcttt gtctggttcc     1740

cttaattcaa gcctaccctt taaattttaa acgtaccatc tacttatgtc tacatctgac     1800

gctgtcattt agtgtttaat gaactctcaa ggctgtgcag tgtagtattt aataagaaat     1860

ttggaaagat actttttctg ggtttaaacc aagataaaat ttctagggct gccaaaagag     1920

caagaaaaac acaaacagct aatgttctgt agactaggaa tggcacataa aagaaatgga     1980

aaggaaataa atagttggaa catgaaagaa aattgggaaa ataatgaata atatacctaa     2040

tgctttgcct atgagctcac agggaaaatc ctgcaaggga tccctcagtc agaccaagag     2100

gattttattt ttggttttat cattttccag gattttatgt ttgaagatct ctaacaagaa     2160

cctagatata ttgagaatag taagttcttg ttaatggatg cttaaagtgg aatatataat     2220

atgttatata ttatatacaa catatgtatt atacataaca tatattataa cataatatag     2280

taatataata tataacatgt tataatatat aggttatata taatgtataa tgcattatat     2340

attccactct aagaatgtat ctaacatatg tgttattcta gatataacag caaaggcata     2400

atctataaga gacataattg ctaaggtgaa ctgcattaaa attaaaaact tctgctctgc     2460

aaaaacggac aacaagccag tgttagataa atatttgcaa aagacacatc tgacaaatga     2520

ctgttaacca aaatatacaa ataaagctta aaactcaaca acaagaaaag aaataaccca     2580

atgaaaaaaa tgggccatat accttaacag accaaagaag atgcacatat tgcaaataag     2640

catataaaaa ggtgatccac atcatatatc acaggggaaa tgcaaatcaa ataacactta     2700

tggtatcaac aatgggcatg agataccacc acatatgtat tggaataacc aaaatccaga     2760

acactgatga tatcaagttc tggccaagga tgtgaggcaa caggaactct catgtattgc     2820

tggtgggaat gcaaaatgct ccagccactt tgaggacagt gtagcagttt ctttaaaaac     2880

taaacatact ctcaccatat gatccagcaa ttgtgctcct tgatgttcac ccaaaggact     2940

tgaaaacatg tccacacagt aaccttcaca aagatgttta tagaggcttt acgcataatt     3000

gctaaaactt ggaagcaaac aagatgtcct tcagtaggtg aatgaataaa ctatggtacc     3060

accagtcaat ggaatattat tcagcactgt aaagaaatga gctatcaagc tatgaaaagc     3120

catggaggaa aactaaaagc atattgctaa gtgaaaggag tcaatctgaa agggctatat     3180

tctgtattat tgcaactata ggatatcctg gagaaggcaa aactataaag acagtaaaat     3240

gatcagtact tgccaggggt tgaaatggga gatgaataag tggaacacag agaattcagg     3300

agagaactga aattactctg taagatactg taatggtgga tacatgtcat tatatatttg     3360

cctaacccca tagaatggac aacaccatga gctaacccta aatgtgaact acagaccttg     3420

ggagataatg aaacctcaaa gtaagttcat taattttaac aaatgtttca ttctggtggg     3480

gaatgttgat aatgggggag gctattcttg tgtgggagta gcggttatgt gggaaatctc     3540

tgtaccctcc cttcagtttt gctgtgaacc taaaattgct ctaaaaataa aattttaaaa     3600

ataaaagaat gtggcattgc ttgcatctaa taaaaaagac cattattcct attgcagttg     3660

aactcttctt cctatatcta ccaccaatca gggaagagaa ggcgatttgt ccaggatatg     3720

gcactgagaa ttatcacaag tgagctagtt caccttcatt gcacagtctc agtcactgaa     3780

gtttccttcc ttcaatagca catcttacaa gtcaagaatg taaggtccaa agccccagga     3840

caaatctcag aagcaaagaa agcagcaggg aaaagtagac cctgggattt gatttccttc     3900

cggttatctc taagcatcat ttccatgata gaaggtgtgg aagcaaataa taaaagtgcc     3960

cgtcactagt gtttatcctg caaagtggtc tgcccttttg agaggcaccc tgccctatgg     4020

ccatcctttg atttcttccc ttggtggaaa tttcctgttt ctctttgaga aagataattc     4080

aaccctgttt ccattgttct tcctcccagg ctgctgtagg aaagcgcacg cacacactcc     4140

acacaaaatg aatttttaaa aaatttattt tcacagtcgc tcctaccagc tctgaaattc     4200

agaacccata tgactgatgg catattcaga taatcgggtc ccaggtctgg aaaagcagcc     4260

ttttccccac gtttctttcc ccacctagga cctcctctga ttcttcactg catcttcgaa     4320

agaaaatgta ttatttgctt gcctggaaga cgctgcaatt caattgattt tatatataca     4380

tatatataaa gaaaacagaa aacatagcct agataccggt cttgagcgtc accgccccac     4440

tcgcggttgt gagcaaagcc ctacggaaga aaccaattcc cagcctagac tcttcagagc     4500

ccaaggtcgg ggaggcgctg gcctggcggt gttgtctggc tccccagcca ctgccccaga     4560

ctcagggctt tgccattggt ccccacctcc tctgctccgg agtttttctc cagctcccca     4620

ccaagccaca caaagtgact tctcggaaac attagccgat tctgctgagc aggaagggag     4680

gaaagggatg atgggggcgg gggtgagata agggaagggc tcttctggct gctggacaca     4740

cacacacaca cactcaaaca cacacacgcc ccacccaatg ggtggccgtg gatggcaggt     4800

cgtgcaaccc cctcctccgc cttctattag cgcatggtgc agaggctaca gcgtcgccac     4860

caccgcgccc ctagctgggt ccccgccctg cgccgcccgc aggagtggag agagggaggg     4920

agggagggag caaggggtgg ggacccgggc gcgctgggag gagtggagga ggcaaagcgg     4980

cgcagctgcc ctcggggagg cggggctgct acctccacgg gcgcgccctg gcaggagggg     5040

cgcagtctgc ttgcaggcgg tcgccagcgc tccagcggcg gctgtcggct ttccaattcc     5100

gccagctcgg ctgaggctgg gctagcctgg gtgccagtgg ctgctagcgg caggcgtccc     5160

ctgagcaaca ggagcccaga gaaaaagaag cagccctgag agagcgccgg ggaaggagag     5220

gcccgcgccc tctcctggag ccagattctg caggtgcact gggtggggat gatcggcggg     5280

ctaggttgca agtaagtgcc ttttcttttg ctgcttctgt ggggagggga ggagaagccc     5340

tcggtctttc gcccgtgctc gcctcaaccg ccacacccac ctgtgtctat tttcacatct     5400

cggttctgga accctgtatt acgccacctg gaaagaagag aggggagaag cttgaccggg     5460

tggttccagc aatgggagga agaagggctg gaagcgtagt tatttcgata gctgggcagc     5520

tcctgtgcgg ttttgactct gtgggtttgc tgccaggttc tgaaactgtg gaaaggaagg     5580

gtagcaatgc ctggtggttt actgtctttt atttctgttt acgctagcag agttgttaga     5640

tggacttcaa ttcaaggggc agctcacatt ttttacgagc aaaaagcatg tgctgtattt     5700

cccatctgca aagctgagcg tgcagaacca gcttagcaga tacaacctgt ggggacagaa     5760

aagaaccccg caccccttaa gagcacacaa acacaaataa ttgacaggac agctctgccc     5820

ctatttctca gcgcagatta tttatttatt ttttcgaata agcactttat agtgaaattc     5880

agaaaagatg cagaatcctt ttaacttttt atcgaattca acttgggaaa ctcatttact     5940

tttaggaaaa aatggatatt ttcgtgcctt atattcaaga caaaaatcag aacaagaaac     6000

tagaaacatt aatgccagtt tttgtgatta tagtaaacat ttcactcatt attttagttt     6060

ttttttttta agttggagcg ttcatagatt atatctactc tgatgttaag agcaatttac     6120

atgagaaact taggggggtt tttaagaagc tagtgtcagt aagataaaag ccaaatcaaa     6180

gtaagctttc aaggaagtga tagcttgtca gttactgaat aggaagtcag tgttgggaag     6240

ttcagttctt ttcagaaaca tatttattat tcttttctat ttcttcttcc ctgtagacaa     6300

gataaagatt ttctttctct ttctttcctt gttatttaaa tatattttat aatttttgct     6360

ttaacatcaa tataaaccta ttttatataa actgcaaacc aaatccaatt attaaactgt     6420

tcattttatt gcaaattctt cagatttttt ccactattta aaaaagttta taattttttc     6480

ttataattat ggtgagattt tttaaaaatt attgattagt ttgaaagcta gtcttatctg     6540

atccctgtgt cgcaaatttt catgattgtt agactagctt atcaacaaca aaactctaga     6600

cagaatatgg tatttgatgt aaagaagaat gtgccctcta tttaggcaac tgatagtttg     6660

gcttaagaca agttttttaa aattttgtag aggtttaaaa ggaggtttcc ttaagtaagc     6720

cactgtgcag ttgtgggact cagtgatgtg tttttacagt gactggatat atgatatgcc     6780

ttgattccta tggtgcaggg ctaggctcac agagtacctg atgcttctac agaagaaaga     6840

tgagtcaggt ctggctctct gccaaaagca tcttgggcct cctttcccct agggcctgca     6900

tataatcatg ggagcccttc tgtggtaatg cttctatgtt tttactacct gttgctgtgc     6960

tgagtttcag aagcaaaata gataaacaaa taaataaatt cagaagagca atcagtaggg     7020

ttctatttat ttaatataat caacccactt tctctgtggc aaggaaaaaa gtagaatttt     7080

tcattttaca tgaataataa aatctatttt ttatccaatt tctattccta ttagttatgc     7140

aaaagagtgt gaagtgctag aaggatttat atggtacttt tctaagacaa gtcatgatct     7200

tgtaaaagag cttaaagttt attgatgtaa atggaacatt ctagatgtca taatgataat     7260

aatttatgac tttccctaaa actctgtctc agattctttc ctcccatctt cattatctga     7320

ataaatgcct tcaccatcca agtattgaaa tcacctttga ttgctctctt ccttattact     7380

ccatttcagc cctttccagc ctgtaagtag atctatcaat cttatctccc aaacttattt     7440

ctatttcatc atacgtctca gatgcctctc attcaccctc ttttctgtat ctacacggcc     7500

accaaattag ttcaggtcat catcataatt tacttggaat cctgccacag cctccatatc     7560

aatctctcca cttctgtaat tttctcccct gcaattcatt ctctatacaa agcaatacca     7620

tcctgtctcc cctaacaaac attggctcac aactgcattt aaaaaaaaaa aaaaagagga     7680

agaagaagag gagaagaaga aataaacatg gcaacacaga gaccaattag caacaacagt     7740

aaatgccttt cctcagcata tggtttactc tctgttctgt cccttctctc caacctcacc     7800

agaacctatt ctcttctcat taaggtgctc ctgcccaggt cgtggctaaa acacatgaaa     7860

caatagcact ctttaaggcc ttttcaaatg ctgttcccaa tgcctgaact ctatgcgtgc     7920

ttactccttc ttaaacttta aatctcaact cgaggttttt ttgttttgga aagatcattt     7980

ttgatcatct tgttaaaagt aggttgtccc gtgttggtct tgatgttgga accttgtttc     8040

tttcatactg cttgttacag catgcaggta ttttgtgaat ttgcatacca aatactccaa     8100

gggaacccag actatgtctt cattgttgac ttagcttcca gaatagtgcc tggcatcaag     8160

tagtaggggg ttcgtagata tttatataaa taataaaata caaaaatatg gattcttcca     8220

gaataaagca tattaaccct ggaaacatga attttgtgat tctatttttt atttgtcaag     8280

catttagtat ttttacaata tcatggtatg atattgagga ggtaaaatta aaatatcctg     8340

agatgtattc tctcttttat cagtgtaggt gataatgtac ttaaaggtaa gtaatttgta     8400

atgcattctt agaaaggcag tgaccacaaa tgtattaaaa tatattttaa gaaaaaattg     8460

gattgcataa actaatatgg ttataagtga ctccaaatct aaaatgataa ccttgttagg     8520

tttaaatctg tatcatctaa cagaaatttg agggccagtc aatagtcact gactatgaat     8580

ttaaaatatt cttttaaaat aaacatagat gcttatgtga gctcagttga tagaaatgta     8640

gtcagatgag gcggaggcca taagttaggt ttccacacgg tctaaattga tgtttgcccc     8700

aggtacaaag ggcacattat ccaaatattt gaagcattct ctaaggaagg ttcagagagg     8760

caatgtgggc ttatccatga agacccatca ctgttattag agtggaagta aggactgcaa     8820

acttcatgct cataaatgat tgtgtcattt tcatactaga attttaccac acacacactc     8880

acactcacac acacacacac acacactttg tatggtgatt tgcctccccc ctttattttt     8940

gcagactatg cttaaagata ttaaacaaac aactagtttt gctattaaca tttggttgaa     9000

aatttagctt tcaattaggt gacaaactga ttaatgattt ttttatgtag caaatggcca     9060

gccacagatt tttggtaaat aatttggtta ccacattaca tcttgaagga ctaaattatt     9120

tcactaattg tgagcaggga tttttaaaaa tttgctctga agaggacata ttgtggatgt     9180

tgtattggag ggcatctgtg tactaattga agatggtcct tcatattaca catcacaaat     9240

tagctaattt attctttaca gaagtattat gacatcttcc tttagaactg tgtagagtta     9300

gattaccact tgagaggcaa ggtcatatta aaatagatat tataaaattg tataaaaata     9360

ttttatatga ggatttatga gagcatccag agaatgtggg tagaatactt ttgtggaata     9420

tgagataaca attttggtgt cctgccattc taaaaaatga aatttcttca ttgaaggtat     9480

cacttaccct ttcctctgcc ttgctggaag gaaatggctt taggcaaaag aaaaagccat     9540

cagctcttgg cagctaaagg tggaatgaag tttggaggaa tgaaaccctt ctgggtggtg     9600

aggaaaaatg ccaggccatg ataaagtggg gaaggaagag gggaatgcct tgaacagtgc     9660

cagtaagcat aatctgccac agacaagttt gaattgacat atgtagaact gaattattct     9720

atatcttttt agttctatag agaaaaccgt tctttccacg tctcttttta aaataacaac     9780

ttactgtaag caaaaaatat gttgttgttg tttctttaac acaggagatg aactatcttt     9840

agatttttta aagtgatata acatggagcc aaaaatgcca tatattactg ttgaaaccta     9900

acgttacttt aactgtaatt tccttgctat tcattttatg atttcctctt gttatgtcaa     9960

gtgttagaga gactgctatt actgatcata aatttcttta aaatgtctcc ttggattttt    10020

tacaaagctt tctgaatcat ttatcaaaat acaataaagc tctaattgca cctaggattg    10080

ttcacttgga aatttagaaa gagtgtgtac atttacaatt aagttagcat cctgccctgc    10140

aatgaatgcc ctttttcttt ttttttttcc ttcttctctc ctacatctca tcttccaaat    10200

gtttgatatg tacgccagta aggcaaattt tactccactt ttaggtcaaa ctattagtac    10260

aaataattgg aaaattgagc ctctaaagaa agataaataa gattagaagc atgcattaaa    10320

atataagtat taaaaacatt cccataagat ttttaataaa aattttatgt gctatatgca    10380

cacctagact ccctgtatta tctgattttt aaagattctt tttttttttt attttttatt    10440

tttttgagac ggagtctcgc tctgtcgccc aggctggagt gcagtggcgc gatcttggct    10500

cactgcaagc tccgcgtcct gggttcacac cattctcctg cctcagcctc cgagtagctg    10560

ggactacagg cgcctaccac cgtgcccggc taatgttttt gtatttttag tagagacgga    10620

gtttcaccat gttagccagg atggtctcaa tctcctgacc tagtgatccg cccgcctcga    10680

cctcccaaag tgctgggatt acaagcatga gccaccgcgc tcagcccatt atctaatgat    10740

gatgatgatg attattatta ttattattat tattattatt attattatta ttattttaac    10800

tgggggtaat ttcactggat gtggtatctg tcaactttta ctagttgctc ctacactata    10860

tgtttttaaa tccaatgtaa ttattttaaa aatatgtcat cttcttgaga gtctatactt    10920

tagaatttga aaaaagaagt aaatgtagat attcaaatcc atgcagatga gtaaaacagg    10980

gaaaaatgag aaaaatgttt catgataata aaatattatg tcaggcacag ctggtcaccc    11040

ctgcaatccc atcactttgg gaggccgagg ctggaggatt gcttgatcca ggagttctag    11100

atcagcctgg gcaataaaag gaaaatctgt ttctacaaaa aaattaaaat ttatatttca    11160

tatattgatt taagctctac taaatgacta ttctttcaag tctaatagac agtgtatctt    11220

ttagggctca gagtaaagat aatttattga ggacattttg aataggatga attaaatgct    11280

ttattggtaa gtgatgcctt tatctgagtg attccttcta ggtaaatatt atgggaccaa    11340

tctttgtaaa tgatctttgc atggaacaaa atattataaa gttgaagtga tgaatttgtt    11400

tccctcttaa caaaatatgt attcttgtta ccccatttac aaacttggct catggtaatt    11460

caggtaggaa aaagggaagt ggcctactca gggatcaact gggaataagg ttcttataat    11520

cccatgagat cagctgacag acttttagga atgaacactt gtagaacagc taggcagaga    11580

agtgcctttc aaaatttata ttacatctct actatatttc agactgtaaa atatttttat    11640

aaagtgttaa aagcacagat aaataaattt gagttcaaat tagtatagtg aaaggaagtt    11700

tatttttccc aaatatttcc tttactcagt atgtggtctt agtcaaatat taatttctta    11760

aatattgctt tcctgtaaat tagtagtatt tacttctaag gactatatta tatgttatat    11820

atagagtata ttatatatta ggagatatat atgtatatac atcgtaattt gttttttcca    11880

aaacagccac tttagtgtct tacacatgat aagtagatat gagtagatgt tcaataatgg    11940

tatctaggca tttaataact tagaatatta taatcaaaat gcattctttt tttttttttt    12000

gagaccgagt ttcactcttg ttgcccaggc tggagtgcaa tggtacgatc ttggctcact    12060

gcaacttccg cctcccaggt tcaagcaatt ctcctgcctc agcctcccga gtagccggga    12120

ttacaggcat gagccacctc gcctggctaa ttttgtattt ttagtagaga taggatttca    12180

ccaggttggg caggctggtc ttgaactcct gagttcaggt gatctgcccg cctaggcccc    12240

ccaaagtgct gggattatag gcgtgagcca ccatgcccag cctctttttt tttttttttt    12300

taattaagtt tcaaggtaca tttgcaggat gtgcaggttt tttacatagg taaaggtgtg    12360

ccggtttcac tctgttgccc aggctggagt gcagtggtac gatgttggct cgctgcaacc    12420

tctgcctccc agattcaagt gattctcctg cctcagcctc ccaagtagct gggattacag    12480

gcatgtacca ccatgcccgg ctaattttgc agttttagta gagatggggt ttcaccatgt    12540

tggccagact agtctcgaat tcctgacctc aggtgatctg cccacctcgg ccttctaaag    12600

tgttgggatt acaggtgtaa gccactgtgc aaggccagca attatgctgt tacaaggaaa    12660

aatacatacg gaaaagttta catcttgcta acattactga taatattaat gtaacagtct    12720

tatgtatgga cgtctcctta atgctaactg agcagtttgt taagggattt tcatatgctc    12780

cgtttaaatc ctcatgacca ccatttgagg tgagaacact aaggctcaga aattacctaa    12840

cctttccaaa gactcacaat ggttactaaa cttgaataac atacacattt cttttatagg    12900

aaagaaatct tatatattcc aagaatacgt ttgcacatac cccacacaga tatacctggt    12960

ggttacgcta ccaagcattc tatcaaatat gtttaaccct taatggagct aaaataaaat    13020

tacatttgca atcaaacata ctaaatcatg taattacagc taatagaaaa caacaaaaaa    13080

agaaagatgg atgactgttt caattttctt cttggacacc aattcctgag gggtatattg    13140

tgttaagtca aaatagagat tttggtggaa gtttgaagac attatgaaaa gagtacctat    13200

gcatttaaag tgtttttgaa gttgttttat aggttgaatg acttcacttt cctggtctag    13260

gagtattatt gcactactgt gacttgactt tgctatgatt cgcatatttt gttttaacat    13320

taaaaaactg aaatgggaaa aaggccttcc ccaaggtaga aaagatttga aaaaagagga    13380

atggtgtaat taaaagggaa atatgtataa aatgtctagg gtgggccagg cgcggtggct    13440

tacgcccgta atccagcact ttggaaggct gaggcaggct gatcacttga ggtcaggagt    13500

tggagaccag cctggtcaac atagtgaaac cccatctcta ctaaaaaaaa tacaaaaact    13560

atccaggcat ggtggccagc acctgtagtc ccagcttctc gggaggctga ggcaggagaa    13620

ttgcctgaac ctgggagatg gaggttgcag tgagctgaga tcgagccact gcactcctgc    13680

ctgggcaaca gagcgagact cagtctcaag aaaaaaaatt aaaaaaatgt ctaggatgaa    13740

gtttattctg aaatggagaa gaaacaggga atgaagttac acacgttgag atcctggagc    13800

tagcagatgg agaagtatga aaagcaaagt gatcttgtgc aggataagat gatggtgttc    13860

attggaagta tttatatatc ttggaaaata aaaatttaga tattctatat tggaggagta    13920

caaatattta gagcatcaca aattgataca cacaaatgaa acctaaatca cagtacttat    13980

tgtcatgaag actcaattat ctaagtcagt taaattgtct aacatcagta atgcaagaag    14040

ttgactttta agggttttaa aacagttttg gaaaactaat ttattttaca ttatgtttat    14100

aataattttt gcatgcaatt tttttaaata tctattatcc acttagatac tgtactttgg    14160

gatataaaaa ccatgggaaa tttggccctt gagttctatg atacgtctca atctatttta    14220

gtgatttgtg gattggtagc ttatcctcta gactaagtgg ttaaggtttt atcagcactg    14280

caatgagata atcatctcac acctgttaag atggctgtta taaaaaagtg aaaggtgttg    14340

ttgagaatgt gaagaaaatg aaagcattgt ccactgttgg tgggaatgta taatagtgta    14400

gctgctatgg aaaataatat ggaagttcct caaaaaatta aaaatagaac taccatatga    14460

tccagcaatt gaaatcagaa tctcaaagag atatatgcac ttctgtgttt actgcagcat    14520

tattcacaat agcaaaaata tgaaaacaac ccaaatgatc atcaacagat aaaagagtaa    14580

agaaaatgtg gtctgtatat aaaatagaat attatctagc cttaaaaaaa gaaggaaatc    14640

ttactatttg tgacagcatg catggaccta gaagagacat gctaagtgaa ataagtaaag    14700

ggacacgaaa acttttgaca gtgacagata tgcttaacag gtagactggc agataagaaa    14760

aaacaaagtt aaagctgaaa tttccaactg atttatctta gcctagggat taatcattag    14820

atccggtcta gttggcctcc aaaatgtgta ggtcaggagt tggcatccaa gttggtattg    14880

gtgccattga ggtttgtagg gagggaagac ctggcagaga tcccaagggc agtggtaagc    14940

ggctgctgag tccctccagg ccagttccaa gaactcacaa cctcactcct ctcagcattt    15000

atactcttcc tggaatttaa aagcaattcc ttctttcctt ccctctttct tttttccctc    15060

tcttccttct tcataaagtt ttattgtaga catcagatat agcaatgaac aacacatgga    15120

gatgtgacgc cgattttaag agataatgaa gagataaata ttcgccacta tccatcattg    15180

taccataaga tatgctgtga aaaacaataa aacaggacag agaattgaga gaaggaggta    15240

ttatttaaag tggtctgaaa aattttatac agggtatttg agtagagaca tgaagtaaat    15300

gaaaaactaa gggagctagc taaacaactg aagaatcatt ctagtcacaa aaaacagcaa    15360

ttgcaaaagc cctaaggcat atttgatgta tttaaggaga agcaagaaaa ccagcatggt    15420

tgaaatacag acagcaagat tgaaagcaga agatgagggt ttttcttgat tttgtaggga    15480

ttactaacct gcgtcgaggg ctgcgtgata aaccaatgct aaaattacca gcatgggtac    15540

aactttggaa agggatgagt gtgctctttt ttaactggat ctctttctgg acatgggtaa    15600

cataaaacca gaaaaaaatg tttgagaagt ttctaatttc tatacaaaaa taatgttttt    15660

gtcttttttt gtgatttaga tgtaaatgta tatgtacatg catgtatatg tatttatgta    15720

ctgatttact atttatgtat atgtaaatgt atttatattt aaatgtccta tattctcttc    15780

ctgtctgtaa tggattggat tcttggaacc tcttactatt tggggcaggg ggcagggcta    15840

ataagacaaa gattacaatt gagagtaact ttaaatgttt gcattttgga aacttaatgg    15900

tgggagtaca gtaatatttt gtatatttcg atcaattttg atgtttatta tatgattatt    15960

tctcatgaaa tagtggtact gcatagatat aaatgactac tgcctagcaa aacagatacc    16020

aaggagacac cgcatgttgt cagggttgac cggttgctaa ctgctgtgat tttgttctct    16080

tactgactct ttctgcctta cggatctcaa aacacgctag tgaatttaaa aatttatatt    16140

ttggtaaaat atatataaca aaatttacca ttttaaccat ttcaaatgta cagtttagag    16200

gtattaagca cattcatgtt gtacacgatc accaccatcc atcttcagaa cattttcatc    16260

attccaaaca aaaactcggt aactattaaa caatgactcc acactcctct cttcccctat    16320

cacccagtaa ccactattct actttctcta tgaatgtgac tattctaggt acctcatgta    16380

agtggaaccc tatagcattt gtcttttcat gtctggctta tttcacttag cataatgttt    16440

tcaaggtgtt catccgggtc gtagcatata tcagaatttt attcattttt aaggctgtgt    16500

agtattttat tgtgcattta tacacatttt gtttatctgt tcatctgttg atagacattt    16560

gggttgtttt cactttttgg ctactgtgat tagtgctgct atgaacattg gtgtacagat    16620

aactacatgc gtcccttcta ttaattgttt aggatgtata ccctaaagta gaattgctgg    16680

atcatgtgat atttctgttt aattttttga ggaaccacca cagtgttttc cacagcagct    16740

gcactatttt atattcctat cagcaatgca caagggttac aatttctcca cacccttgtc    16800

aatgtttctt ttcctttttt ttttttaaac aataaccatc cgaccaagtg tgaagtgata    16860

ttttattgtg gttttgattt gcatttccca aatgatcggt gatgttgagc atcttcccat    16920

gtactgattg actttctttg gaaaaatgtc ttttcaaatc ctttgttcat ttttaatctg    16980

cttgtttatt ttttgttgag gagtaggaat tttttacata ttgccaatgt taatccctta    17040

tcagatatat gatttgcaat tattttctcc catcatatgg attgcctttt cactttctag    17100

tagtgttctt tgatgcacaa cagtttcaat tttgacaaaa tccaattcag ctcttttttt    17160

cttttgttga ccgtgctttt ggttccatgt ccatgtgcca aatctaatgt ctcgaagatt    17220

tttccctatg atattttctt agaaatttac agttctaact ctgacgttta ggtctgtgat    17280

tcattggtga ttttttaaaa attcctatat aattcgtaga ctctaagaga gtttccagct    17340

ttcccatacc cattgtcccc agagatctgg tttttagtct gaatgtgcct tactctgaac    17400

atgtgccttc catttcaaga actcccattt cattttgttt tgttctgttt tttcttttat    17460

accagtatta aaacttttga gttgttgtat aaatatacta gcaatttagg agaattcctg    17520

atgggaaaga atatccttgc ctagctagtt aatgaattta gggacccttc attttctaat    17580

cctagatatg attaaatcaa acaaggattc attgtgctgt agttgtaatc cacacagacc    17640

attttacaag gctttgcaca gagaaggtgc ttaatacttg agtaaacaaa ttgaattaat    17700

gagtaagaaa gaaaagctat cttgttttct caacggtcaa gtagatcaat gatttctact    17760

atttagaatc ttagatttat tttaataaag caagttcaaa aatctcctct ctctgttaat    17820

ttttagtaaa gtcacttatt tttcactcag ttttgttaaa gtgttttcag aagagtttgt    17880

taccgaaaac tgaagtttta aggttagtgt ttataccaca gatatttctt gtttttagac    17940

aatccttgtg gaggttaagt cccctaggca ataccttttc ccactgggga gttacaagca    18000

aatgaaaaat ggtgactatt tatggaaact ccaggtcact aagtaaattt tgcattttca    18060

tgaaaatatg acatatggac atttaaaaaa atgaacaggt caattcatca gttagaataa    18120

taaaaagaag tctgtaaata aaagttaagc acctttgtca ttgaattgtt gtgaaccgtt    18180

tttgcctatg cacttgcttt atctcagaat ccaagcctcc tggtcaaagt tatattccta    18240

ataaatttaa aaataataat ttaataattt taattccttc tggaatataa atttgatcag    18300

gagtcttgga ttctgagata aagcaaatgt ttaggcaaaa cacttccttc tggaatataa    18360

atttgaggaa ggataggaat tattttcttc ctattcattt gtgatcctgt gattgttatc    18420

taatttggaa tattcttcat gactccaatc ctatttatat ctgtgaggtt ctgaaaattc    18480

tgccccaaaa tggcagaaag taagaaatac tatcacacat ttaattcacc cttaaaaaaa    18540

tagccatacc ctttatcttt gaatatattt ttaacaacaa caacagaaag agaatgcatt    18600

ttaaacaata tcacatgagt ttcatcatat tcccagatta tggtgagggt tcctagatac    18660

cttgccataa tcacagcctt tagttccaag agagagcaga gaaataagaa acacaggaag    18720

tcatatctat gaacatgtta gtttgcaaaa ggtttgttag taaactcatg ttatttatac    18780

catagtactt taccatctcc agatgaattt ccactaaata aactgttcct ttagactcct    18840

caaaccagat tacccccttc ctttgctaat atagattctc aaacaatgtc ttcatcaaaa    18900

atcttatgag tagatgtcac tagttttgac aatgtccaca aatgttccaa agaatacttt    18960

ggcatgcatg cttcttaact cacttatttt gatattgaat taaagggctt ttaacaattc    19020

ctgccccatc aggaatattt catcagcagc tgttactgtg cttggatttt gccttcttga    19080

atgaatacct agtcttttct cactttagca ttaagttctg gagcatccgc tgctaatgaa    19140

aaatcctctg actcatgcta gagcattttc atttttttaa aaaaacaatg ttccttgtat    19200

cttgctggct attgcctaag ctcattattt taaacttttg cataattctg ctcagtccta    19260

gagggtcatc attactgtca atgattaaac ttttatgcac ttgccacatt tattattttc    19320

ttactttcga tcattttatt atttttcttt ggttcccatg atattccaat gtttttgtta    19380

ttaaatcttt caacatcctc ggtgtgttca gtgtatccac atttatcaaa cctgatggat    19440

ttaagaattt atataacctt gaaagcaagg cccacatcct gtagacactg aataaactaa    19500

tgaactttgt attggcagga ctaaaatggc tgtgtgtggc atatattgcc acctgttggt    19560

agaaggcaat gtagtcttgg ttttgctata agcatacatt ttagtcttta aaatattctg    19620

agttgaaagc tccctaagaa gaaaaggttt tgtatatgca atacaaaagc ttttctatta    19680

taaagtaagc aaatatattc tcgttcctaa gaacattagc tttaggtata caaaatcaac    19740

ttagaagaaa gttgctaaaa tcactaataa taacagttac aatgtattgt gcactgaaag    19800

tgtaacagga aatgtgctaa gttattaaaa ttcagtgtct aattttttcc actaaaataa    19860

ccttaaagga ttatcatttt cagctccggt ttgctatata agaactgagc tttagagaag    19920

ttaattaaat tccccaagga cataagctag taagcagtag agatgggatg tgaacccatg    19980

cctctctcac tctggagcca tgaatttaac aactgggtta tgctgtctta ctattttact    20040

gcagatctat attttaaatt aaagccataa acatgtttgg caagataaaa cataggtaac    20100

aaatatactc cacataagat tttcgtaagg ttttgtgttt attggccaac tcatggctta    20160

ttatttaaaa atttcagtct gtatagggaa gaaggataat aatcttgctg ttatttattt    20220

agcctaggca ctgtggtagg cactttacca aaaccatttc tattctacat gataacttta    20280

taagacagat atatttctct ctttcattta tggggaattt gcataatgct gcagagctaa    20340

ttatatggaa taaacaggaa attcaaacct aagtctgcct ggtgccaaag ttattactat    20400

gcactttctc ctaaatcatg ttgatgtttt gagggaagtg gatacatgta taataatatt    20460

ggaaatacat tttctctcta attatttaaa taagggtata gaacctgttc tgcagccata    20520

agtctgtgat aattttgtgc tctcaataaa gtcttaacta acagagagat gggatttaac    20580

gtgaactaag aagtattttc tgtcttcctt tatacatgct gtacagataa gactttatga    20640

attttttatt aaaacgttca gatatgccag caaatgttga cactaatctt aagttttccc    20700

agggtaatac acttcttaag attataaact ttaatttctt tttttttttt tctttttttt    20760

ttttttttga gacagagttt cgctcttgtt gcccaggctg gagtgcaatg gcccgatctc    20820

agctcactac aatccacctc ccgggttcaa gcagttctcc tgcctcagcc tcctgagtag    20880

ctgggattac aggcatgcgc caccatgacc agctaatttt gtatttttag tagagacggg    20940

gtttctccat gttggtcagg ctggtcttga attcctgacc tcaggtgatc cgcctgcctc    21000

ggcttcccaa agtgctggga ttataggcgt gagccaccac gcccggcaaa ctttcatttc    21060

ttataaactt gaggaatact atattttaaa aggctataca taagactaac ttctatctta    21120

ataataaaat aataaatata atataaatga ttattacagg gtattatgaa atacccaaat    21180

cacaatattt taataatcat agaatttaga aatagtccct atcagttgtc tgaatataaa    21240

attatcgcat atacagctta atttgttttg cataccagtt gttcaactac tataaaatgc    21300

cataaaattg aatgatttta ggacatgaaa tattgaacta ctcttgttga agttattaaa    21360

ctgatttgcc atctaccaaa ttaagcattt ctaagaaata ataattattt taagaattta    21420

tttacatgat taacataatg ttacttatga aggatgcaat ggtaagattt cagcaatcag    21480

gcaagtattt aatgaaaagt atttggtttc atatatattg tatttgattt catatatatt    21540

gatacactta acattagagg ttctaaaatg agtagccagc ctgcctgttt ttcttgtgat    21600

attatacttg gcatactttg tttttataat ctaaagaaga ggtattaaaa aaagagtcag    21660

agtgcttacc attggcagtt ccttttaacc ttttaattta taaagacatt gcaatcccaa    21720

tgaaaataaa aatagaaatt ttcccatttg gaattagata atctggatct agttgggaaa    21780

ttgtacacac ataaaagagt aatatctaat agcaccaacc ctaatacata atgttatttt    21840

atgcaaatag ggtaattaaa atagtatggt gacctacata gatagttcat tggaagaaaa    21900

tacgatatcc agaaatagac atagttacat atgagaatta taaaggtagc atcttaaata    21960

ggttgaaaga aatattattt aatagttatc attgggacac ctgggtagtc atgtggataa    22020

aaataaattc agattactgc tttgccacct aacccaagat acattttagt ggaatcaaat    22080

atttaaaata acatacaaac cacaaaactg ctagaagaaa acatgtgaag gttttgtttt    22140

cttttttctt ttcacctgag atggataata tatcaatgtc attacaaggt ttgagggagg    22200

aatatctcac atatgcatgt gaaaacccag tcatcacact tatgaagtac ttgaagtaga    22260

aattattttc taagataata taaaacacag gagccactgg agaaaggatt ggtgaattca    22320

atttaattaa aatgtagatg cttttaaaag ataaactacc ataaaccaaa agaaacaaaa    22380

acagcaaact tacaaaaata tttgtattgt ataccacaga aaaaaagcta attttattat    22440

tttgttaaga gttcctaaat taataaaaca ctgatagtct attaaaaaag tggacaagac    22500

tacatacaga cagagcacag aaaaaaaagc acaaatggca tctgaggata tgaaaagatc    22560

cctgacctca ctcacaaaag aaaatgcaaa ctaaaatgat aagaattaag aagttttcgg    22620

ccgggtgtgg tggctcatgt ttgtgatccc agcactttgg gaagctgaga tgggtggatc    22680

acatgaggtc aggagttgga gaccagcctg gccaacatgg tgaaaacctg tctctactaa    22740

aggtacaaaa attagccggg tgtggtggtg ggtacctcta atccgagcta ctcaggaggc    22800

tgaggcagga gaactgcttg aacccaggag gcagatgttg cagtgagctg agatcgcacc    22860

aaggcactcc agcctgggca atgagagagc gactccatct caaaataaat aaataaataa    22920

ataaataaat aaataaataa ataaataaat aaaagtttta ttccccactt attaggctca    22980

caaagatgaa aaaaaattta tgaaatactt tattgaaggt atgtgcaaac aatccctgac    23040

acattgtttg gggagagcat ggattgatag gcctttatga aggagttacc aatataccaa    23100

taacctcctt ggtagtttca aaaggtggca tctttccctg tttggtattg gagacccaat    23160

acaagaaatg ggaaagtgag catcaagcaa tgcaagcttt attcgatggc caaagaatgg    23220

agaagtgcaa gtatggcgca caagctaact tcttgactag tgaggagtga ggaaattgaa    23280

atagaaagta tatctaatga agaagttggt cattaagagt gaggggagga atgttcatgt    23340

cttttccaga aataggtggt gaacttcttg gaaccagagt gccgccttcc tttttgtcct    23400

tttatggctt cttctggtca ttgtcatggg gattatcaac tgtcatggca ctggtggggg    23460

tgtcatttag catgaaaatg agattataat gatgcctgag gtcttcttga agtcctttag    23520

tcaactatct tggttctaag caatctcagc tgctctggtt acaaatggaa cattttacct    23580

gtttcttaaa gatcagcaga gttagggtag gatagaaatt cagctatggc cctgtaggcg    23640

ttacactagg taacaaaaga gaattcggca atattttatt atggcaaatt aaaaacgcac    23700

atacaattat gactcagcaa tttcactctg aagcatttgt cttacaaata aaataccgta    23760

ctgtgaaact attcaagaga atgtcctcac ttataagtga gagctaaatg atgagaacac    23820

atggacacat aggtgggaac aacacacact ggggcccatt ggagggtgga gggtggcagg    23880

agggagggga tcaggaaaaa taactaataa gtacttggct taagaccttg gtgatgaaat    23940

aagatgtaga acaaaaccct gtaacacaag tttccctgtg taacaaacct gtgcatgtac    24000

ccctgaactt aaaataaaag ttacaaaaag agcccacaaa agagtaggtt aaaaaaagaa    24060

aaaaactaat gagaagataa ttattgtagc tttgggaaac aacctaaatg ttctacagtg    24120

tgggaatgac taaataattt gggtacagct gtacaatagg actttatgaa gctgctataa    24180

aaagaagtag ctttatacat gctgatacag aaagatttcc aagtctgatt tttaagtgac    24240

gaaggaaggt atgaaacaat gtttatatag ggtattattt gcatgaaaag aaaaatgaat    24300

agatgtatac atgctgataa aaccacatgg atggatacac aaggggttgg tactgtggtt    24360

gtccacaggg gaggaatttg gatggctggg aaacattgaa gagtgagaga attatttttc    24420

gttatacata cttttgagtt ttgtggctaa atttattctt caaaaataaa tataagaatg    24480

ctatttatgg ggaaaaaatg ggagtcataa acctgcaatt tggacctaac ttttcaactt    24540

aaaaatgttc tgttcttgga gttactaact gctctgatgc ttaggatgat aatcaaataa    24600

tagttcctct aaaatatgtc tggaatgaac ttgaatgaat gaatgaatga atgttttttg    24660

caaaccatta tgtgtgtaaa aatgtagagt attaatataa ggtttattta gaatagagtc    24720

atctgcatta aagaaacttc gttatacaaa aatctaaata aaaaaatgtt gtacagtagc    24780

tctgaggagg tggatgaccc aaacactgag aaaagaaaag aggcagaggc tgagcaggat    24840

agttcagttt gaggtaaaga agcagcctca cccagcctca gacaagactc cagggactgt    24900

gtgaaaaacc tcattttggc caggcgcagt ggctcacgcc tgtaatccca gcattttggg    24960

aggccaaggc gggcagatca caaggtcaag agatcaagac catcctggcc aacatggtga    25020

aaccctgtcg ctactaaaaa tacaaaaatt agctgggcgt ggtggcaggc acctatagtc    25080

ccagctactc aggaggctga ggcaggagaa tcacttgaat ccaggaggca gaggttatag    25140

tgagctgaga tcatgccact gcactccaga ctgagaatct gtcaaaaaaa aaaaaaaatc    25200

tcatttctag gcctatgttt cccagaaata tgtcatgaaa ataaaactgc cctcccaatg    25260

ggaaaacata tatatgcaca aaaaggtaaa tatttttaat gttaaagtta ctgcataatt    25320

cctttaaaga gtaattatat atttctattc atttttgaaa accagtttta gtaaagacaa    25380

agttaaaaga tgacaaactg gcaaaagaaa aaaaaaagaa atttttgtga aaaggtatca    25440

atatccttag cgtgtgcaca cacacccaca cacacacaca atcccttggc aaacaagaaa    25500

ataatgaata tttcaataga aaaaagatca agagactaaa gacactgacc aaagaagaac    25560

tagaaatgtt tcacgaaatt cacattttag ataaaaacgt tttaaatatc aaattatgaa    25620

gttttttttt aaatgactat acttaacatt gtgggaaaat atatgcttac atgttgctaa    25680

aaatgatata catttttata gcctttctgg aaacattttg tcagtatgta tatatatata    25740

aaagaagaca ggttgggtgt ggtggctcat gcctgttatc ccagtgctgc caagaggcag    25800

aggttgcagt gatggagtga gccgagatca tatcactgca ctccagcctg ggtgacagag    25860

agagactcca ttaaaaaaaa aaattagcca gacatagtgg tgcacacctg tagtcctagc    25920

tacttgggag gctgaggtgg gaagaacact tgagcccatg aggtttggag gttgcagtca    25980

gctatgattg caccacagcc tgggtaacag taggagacat tgtctcttta aaaaaaaaaa    26040

tcagtaattt tcttggaata ggttaatttc atttattttt ttctatgctt ttcagttttc    26100

taaattttct cccaatgaaa atttgctata tttatattca accatattaa taaccccaaa    26160

ttagtcacat gtgcaacttt ctgcaaataa atgtgtcttg gatttaatgg aaatgaaatc    26220

ttttcagtat agcttctccc tgttatttgc gtacaagctt caaactgcat aaactatttt    26280

aatggcaaaa attaagttag ggttaatcaa ccatctagga ttgtatctgt gcctaggttt    26340

ctaaaacaat taaatacttg atcgctttgt tggatgttca aagatttggc aatttgtcct    26400

taaatatatg tttcaaataa aatatctaca attttaaggt gcttaagtac tggtgaacat    26460

gtcaaaatgt gcctaatgta tttttaagtt ctgctgtgaa cttaaaaact ttgggatttg    26520

tgtaatccca aattagagaa ttttaaactt tagttggtgt ccaccatatt gtcccccttt    26580

tcatccatct gaccaaactt ttaaccttcc tgtttatggc tggggaaaaa aaaagctact    26640

ttaattaaac ctaagcagat agtgttgttt ttaaattgta tttcgatgtc actaaaatgg    26700

ggaaacaggt tgtaatagca gaatccttat attttttgca catatcagcc tccataaaag    26760

gatggaaatt gctttgtttt tcaatgtttt aattttttta atgaggagaa aaagagcaat    26820

tgagagtgcc ataaattaaa gatagcgttt ctgatgtaaa atcaatgata gttatggatt    26880

attgtaaatg tttgaagatg ctcttggaac actgaaaaat cttagaaaat tttgttaaat    26940

aataattaaa attgtcttaa attagtgtga catctatgtt aaaggcaata taattagata    27000

gcgtgcttct tcaagtgctt gggttaggag aagtatttca ccatcttcat tcatcaagca    27060

tttaacaatt ttatatgatg tgccagatat catgttatac cttggtgata atacatgcct    27120

aagacaaatt tcctgtctat gaagtttgga atctagttga aggagacagg cgtgatgaaa    27180

gaaataaagc actgtagaag taggataaaa atccgcattt aggggactgc tggcagctca    27240

aagcagactg gagatatggg agaaagagaa gctgatgaag ggttgaattt atatttgagg    27300

gaaggaagga ggcgaagtca gatcttttca tacaagaggt attgagccaa atattacaaa    27360

gcaagtaatc aggtgatcag gatagttgaa actgttcaga taaagggaac attatgagga    27420

tgcagaaatt atctagctga cctttgggga aattaaacgt agaataatgt agctggaatg    27480

tagactgcaa atagggaaac agaagaggct gtcagcatca ggttagtaaa accttctatg    27540

acagaccaaa gacatgacag gttattctgt acatagtggg gagctgtaga ttataatttt    27600

tttttagtca tgggaagatt atcaaatttc ctattgcaga caaagggtct cttgttcatt    27660

gaatgaatat tacataattt attcaaactt gcttggtgtt aggcaactaa atgttttaag    27720

gcattttttt gtagcacagc tcttttttct cttttttttt tttttggaaa cagggactca    27780

ctatttttgt atttttgaag ggaaggggtt tcatcatgtt ggtcaggctg gacttgaact    27840

cctgacctca agtgatctgc ccacttcggc ctcccaaagt gctgggatta cagacattag    27900

ccaccacgcc cagaaagcac agatcttttt tcaaaagaaa tttgtgatgt tttaataaga    27960

aagaaattaa aaaaaaaaca gatacaatgg aaagatatcg atcctggaac ttttaaatct    28020

tggtttagag aaaacagttt attatttgaa caacttcaaa cactcaagtt aaaaagcact    28080

aacaaggcac atctcacttg cacaaaaatg ataccaatta tcaattgttg gtggcaacag    28140

aatggagcag cacagaaatc tggagacccg ttttcagttg aatgctcata gttctaaaat    28200

aggctctgat ttggaattcc ttgtcttact tttcagtttg attaacgtgg aagtctcaat    28260

atcttcttat gctgtgtgta ggaaaagtat cttgatcagt atatagaaga atatcccaca    28320

atgttactgc aactaagaaa aaattaaccc attggagaaa acatttttaa tcagttcatt    28380

aagagtctaa tgaaggtgca tatacgaaaa gcaagatgta ctttaattaa tgattgatgt    28440

tttgtgattg aagcttgctt tcctaaataa tatttctata cttcagtaca gaatgtaagg    28500

tccttgctaa tgccttattt ggtttcttag tttcagtctt actgcagtct gcttttattg    28560

taggcttatt acatttatca ccatcattaa tttaccatgg tgttttatct ttttaacttg    28620

ttatttagat cacattgtat aatgctttat ttctggtctt gtagcaaagg aatgcataca    28680

acaagcatgt aaaactttat tgaatagaac agtctttaaa ggggaatcat ccataagtca    28740

gataaatcca tgagtagtat agatttatct actgtaaatt ttctgtcagg ctgttaaaag    28800

tagggccgtg taaatcttac tgtcattcac attataatag gcacacttac caatatacca    28860

actttatagt tttttctccc cattttacgg gtttagggct tatttttttt gagatgtcaa    28920

gtactatttt aacattgtac gtgtttctta agaaacgcca tagaatgaag acaataggga    28980

agtctatttg tgatatattc tagctcactt acatttttta ctgtatctta caacagtaaa    29040

catatcacac tatacttgaa tttaaatttt ttcaagtatc attgcattat tttgcacata    29100

aacatattct tagatggtat caggttgatg atgatgagct tcatggtaat tatttaaaac    29160

tccataatga gatttgtttc caatctaatc aagaagggta agaatttggg gaaaaaaaat    29220

ctgttctata gtaattaaag ttagccatat gggcacttgg ctctaaagac ttggatgtag    29280

tgaatctacc caacccccaa gactaatgac ttggatggtc ttactgtatt ctcttgtcca    29340

tagcaaagac tgatgaatcc agccagggaa ttctccacca gctctgcttc tctgaaacca    29400

caaagtcagg aaatgtaatc agagtgctca gctgaaccag agcaagagct ttcctaatgg    29460

ctaactgtga ctttagaaat cacatccatt agataaagtg attaaatata catcagtctt    29520

ttggcaagag agccatgaag atattgcaat agaaccttac cacatgaccc acatcttttg    29580

cttgaaaaag aaacatgttt tcacctttga cacatatcat ccctaaattc ctcagctcag    29640

ttgcaggaag caattttttc atgataagtt gtatgcagtt cataatttta tataaaccat    29700

aaagtaattg tgtggttgat aaactttata aggaaaatgt ttctgacttt ctcatttcac    29760

caccctgatg tgtgggtttt tgttttgtat tattcttctt tttaggcttt tcatgcttca    29820

agacttcaag atattttgtt aaattcttcc cttggaagcc tttgtgtcgc caaatcagat    29880

ttttttaaaa cttagatatg aatgtcttaa gtgtctactt aggaaatatg tgtgtatgtc    29940

tgtgtgtgcg tctgtgctta tatatagaga gcaggcaaat tactcttagc actctgaaaa    30000

agcttttttt gttaaaataa tgttttaaaa atattataaa aaaagtcacc gtcaaaatag    30060

cattcgcttt atatttgtag ttgaaataat tcctgtttct tactcttagt tataaccatc    30120

ttttgattaa taatatactg cccttcacat tttaatacac atgcaactaa gccgctgatg    30180

taatacatat acttaaaatg ttctttttga gctttgaata accttttgcc ttttccctgg    30240

tgatcaccag tgggcaagat gattgacaga gaatgtgttt acaaacatgg aatcattgat    30300

gactaagtta aaagtgacct cataaaatat agttctaatt cttatttaca gacaaaattc    30360

taagagctca attcaatgtg tctaggataa tagtgggcat agttaaataa ataataggaa    30420

gtgattatca tttacaaaat ttcattagtg aattactaaa gtatacccct atgcatacta    30480

attcctcttc cccaaatcaa aacttctcat attcttaaat ttctgaattc ctaaaatcag    30540

cagagatgaa gggatggacc agcaactata attttgttgt gttttgtgtt tctgaggcac    30600

atatagggat acctagtttc atgaaaccaa gtggtgggga cattacacac aaagagaaag    30660

ctgttaaagg cagaatgccc agacaagaat gaaaatgaaa ttcctggagg ggcatcccca    30720

tagtttttct gataatctct ctccttacat aaaaagcttg aattactggt aaattatcca    30780

tgcaggaata atagaatcat agaatttttg tagtataagg aattttattg acatcatagt    30840

tgaaagcagt cattttgtaa atgtttttgg tgcccagaga tactttaatt atggcagagg    30900

aagttataga caagtccacg aaccaggagt agaaaagttt tcaaatgaga aatattgcag    30960

accaagcatg ttaattttat tttatttttt attttttatt ttttattttt tttgtgagag    31020

ggagtttcac tcttgttgcc caggctggag tgcaatggcg caatcttggc tcgccacaac    31080

ctccgcctcc caggttcaag caattcttct gcctcagcct cctgagtagc tgggattaca    31140

ggcatgcccc accacgcctg gctaattttg tatttttagt agagacaggg tttctccatg    31200

ttggtcagac tggtctcgaa ctcccgactt caggtgatcc acctgcctcg gccttccaaa    31260

gtgctgggat tacaggcgtg agccaccatg cccggtctga ggtattgtta tatacacggc    31320

aactctagcc ttataatgca ttgcccttat agtctactta gggtttttag gaatattgtg    31380

acctaattta aaagtttgta gagagattct aattttcaga attaacagta ctttcatttt    31440

ctctgaccat tgaaatactc ctaaattgca aaatgaagtg gaagtacaca gtagattagt    31500

aaaacatatg gttcaatgca taaattgaaa taaataaaat gagactattt agaaaatgat    31560

aacaaataca acagtaaaaa gaactcatta cataactttg tgactttttt ctttttcttt    31620

cattggttcc ttacattttg aactctttct cactttttct gtttccttct ttttaaagta    31680

aggaatagag aaagagtgta tacaactgaa taagtattta ttgattacct tctatgtacc    31740

ccattgggct aaatatggga gtagaaagat gaataagatg gtcacagctt gggggagggt    31800

gattatgtca aatcatgatg agaggagttt tttgtttgtt tgtttgtttg tttgtttgtt    31860

ttgacggagt tttgctcttg ttgcccatcc tgaagtgcaa tggcgtgatc tcggctcacc    31920

gcaatctccg ctcctgggtt caagcgattc tcctgcctca gccttccgag gagccgggat    31980

tataagcacg cgccaccacg cccggctaat tttgtatttt ttttagtaga gatggagttt    32040

ctccatgttg gtcaggctgg tcttgaactt ccgacctcaa gtgatctgcc cacctctgcc    32100

tcccaaagtg ttgggattac agacgtgagc cactgcaccc ggccactact ttggaggttt    32160

aagaaaagta gttgtaggtt taaaactctt ggactggctc ctgagggaag aattaaaatg    32220

ccctattgga gcatagccac ctatctagga tcttgagtcc tagataggtg ggtgggaatg    32280

agtatcagga aattgggctg ggaccactta ggacaggccc ttgtgggtta atcccataag    32340

ctattgagaa gccactgatg attttttaac agaagagaga tgtgatcaat ttttaattac    32400

cactctgaca gtactatata ttctgtggat aagacaaaat gagagtggaa acctagagac    32460

ttggagacca ttgtgatagt acagataaaa gataaagaga aaaagcaaag ggaaagggtt    32520

tagggttgat ttagaaagta taatcaatag cccttgttga ttagatgtta ctctattctg    32580

agttcccagg gagtaaatgg tactttttat tactagcact ggctactgac tggcaatcat    32640

ttaaatgagc gggttaaaat aagagtatat gaaaaattag agtttgtgga acttgagggg    32700

catatctagg ctggaaaata gctacttgtc attttttttt tttaatgttg gaagactttc    32760

tattcttagt ttgtaggaaa aatgtacatg ataatcaaca aaccgttaca catgtgctaa    32820

ggtggtatat taactaattt tcattggctc atgagttaca tgctacctgg catcctcttg    32880

cctcttcctc tctggagcca cagattgtta gcagagaagc tggaagaacc taccatcttg    32940

ccataggaaa aaggtttggt ccttctggaa catgcctgtg aaaagttgcc aatttcctat    33000

gtaggtcctg gacttatctg gaattcaaat atgactagac accatgtatt ttatctggca    33060

ctccgatcct atgtgttttt ttttaaatat ttatcctcct ttgtctcttc atgaccttat    33120

tatacaagtt ctagatcaga gtgtaacagc ctctttaaat tctgtggcat gaactttaaa    33180

tgcctgtgaa gaatggggct gggttacgat tggctaccag tgaattccag gtaatttaga    33240

cacttcctgg atttgttttc cgtgtcatca tttattgatt acttcatata aagtcttaat    33300

gtgtttatta ctcaggaaaa atgatggaat agtagcagca atgccacagg tgtgttgtga    33360

acattaatta gttaattaca aagcatttag ttgagaggca ttctaaatag cacagaactc    33420

aaggctttcc tccccaacca ggggtccact taaatagctc tttactaagt caggagaaac    33480

aaacacatct tgtacatgag gtacatcaac cactaggcat gttgatctcc cagggtgatt    33540

ttctgcatga aaacctatcc cctgggtgtc aagagctttc taagagcaat gattcatgaa    33600

ccctctggat ttaggacaat gctatgaaat tattttcatc tgtattctga aataattact    33660

tgatgtccta ttaaagtatt ttatattttt tgccagaagt tgtaggtgta attggaaaca    33720

acagaatact caaaaaaata aaagatccca aaggagaata agaagaaaga gagagaggaa    33780

tgggctataa agacggcaag agtgatggac cagtgcctaa agattttaga cagactctca    33840

aatttactct tcttatgttc tctctaaaca ccattcttat tagttcagca tcactgtaat    33900

aactaaaaat attttaaaaa gtggacaagg cagatgtcag caaattgatg tggagaaatg    33960

ggacagacac atggatgact cactcccagt cccaattccc tattttattt tttcatttga    34020

aatatccatc tcttcagagt tctgtctagt gtgaggttca aacaatttaa atgcttttct    34080

caaaactatt gtgcaaatgt ctgtttttct gtatttttgt gtctttctga tgttcctctc    34140

ctggcttttc acctactatc acaaattaca tactttatta tgtactttta tatatcatat    34200

acttttcaat gagcttgatt cccacctgaa cccacgcttt agagagaaca atgataggtt    34260

tctctgcacc tgctccatat ttagtaagtt tccaattcct tttggtgtca aacaatagca    34320

ggtatctctg cagtccctta ggtcactaat gtgcttggtt ttgttgtcag ggtagcagct    34380

gaaccatatc tttcacaaac aggagataca tattttttcc cagcttgagc agagcatctc    34440

acatttatta ggagaaatgc ccctagaggc ccatctgtgt gtctttgacg gctcaagtat    34500

tatgtacttt aagaagttta atacattttc tactggacag tattgagttg ttttaaaata    34560

ttaaaatctt actttgctga gataaataaa aggtattcag gcttttccaa gacaagtatg    34620

agaaatgcca agttacaaca ggttcactaa tgagggagaa gaaaagtttc atgataatac    34680

tatgatcttt gctattgcat ttggaattta gttagaccta aataatgaga agacttttgt    34740

gatgatctat tcaattttta tggcctatgg tctttttgag aaattgatta aggcagggga    34800

aaggggatag tggtagggca tcactgactc ttgttttctt gcttgtttac tcttttcacg    34860

aagtggtaat acaaattacc tcccacagca gcacaggtta ctcaaaagcc cagaggagca    34920

ggagaatgag acattcctta ttcatatttc agtaaggtat tcttctccat ctttgttgtt    34980

tcaaggcaga tgacaaaatt tagtagccat tttagtgcag aatactccca aattcaggga    35040

ggaagctaga ttcagttgtt tttcagtaat attggaaagt gtaatgtgta atgcccatgt    35100

ttaaacagtt gctttcttcc taacatgata aacttctatc gttagaagat attctcttgg    35160

gatgaaaata aaaagatata gcataggccc cgtttatttt atttggggag gaggtagtag    35220

tagcggaaaa tataaccagc gataccatct tcattactaa tgatgacaac ttacaacatc    35280

aggagctcag gaagaaggaa agcaataaat accttcatct tcaacaggat tttctggcaa    35340

ttatatctgt ttttgtttgt atgtttgttt gttttgtcct ctattaattt gaaatgccta    35400

gattgttttt ctggaactta gttttatatc aatcaataaa ccccttttcc ctactttttt    35460

ttgttacttt ttttcaagag catactgacc tcaacgtggt gaaagttttc aaaagaggcg    35520

gatataagct taaaacctgc ctctgcccac tcctgatcta tctcaaatga acatctgtaa    35580

ctctccatga attaaaatga ggataataac atgttctaat tgttatagaa aaaattacat    35640

ttgtagcaca gggtagctgc tttatgcata tttttttcta agttatgcac accacaattc    35700

agtactaatt ttgtcatgat gtcctgaaga aatcctaaaa atagagattc tgtgaaagaa    35760

cattgagtac cacataatca agatatatat gtcttgattc attgattgat tcattcattc    35820

agggcattat atagcagtca tttttttgct acccttccac atggatgata gttaaagact    35880

ctactgaagc cactagatac ccatcttata cacaggctgt aatattttaa ctcctggagt    35940

aattggggta tattcacaat aaaatcagct caaatctaat ttatttcttt catgaggtct    36000

gaaatgtagt caaagcttcc atttagttcc tcgagaaaaa gcttctggca aagataacaa    36060

aggacatgat tcaaatgctt tctgtcttac actgctgctt cacatcaggg gcagaggatt    36120

ttatgtttca tggccttctc ctcccacata ttttgggttt tctcatctaa tcatacagct    36180

atgatgtcag tgatggaaat ttccacctct tagtttggta tcttgattgt tttttctttc    36240

cctgtttgca caaaggattg taggtggctt tccagaaaag agacatgaaa aggatcacta    36300

aaaggagctt caaaacaaat tagattattt gttgtgggga gaaaaatcat agcagcagga    36360

aatttcattg tgccttttac acaagatcta acatgctgat gaattgctag tataatgatg    36420

atttatagag ctgagtttct tttgaccaag cccagtactc ttgcaaggtt aaacaattct    36480

aatggcggat gacttgaagg actattttct aagcgaatgt acaaattaca agtccttagt    36540

ttcgtaagat gctgtttcat caaaggcttt tctttgtggt ttctcatatt tcatattcat    36600

gttgactccc aggtgatagt taatggtatc ttttttagta gtgctattat cagcttcaaa    36660

tgaaataata gataataaaa agccttatta ttaatgtcat attttgatat atttttaact    36720

ttataaggct ttttagtatt attaatgtca tattttgata tacttttaac cttatacttc    36780

atttattcta agtaatgtga tgtgatcaat aatttttcaa ttaagtactt ttctttttgt    36840

ctgtgctagt ttagtttagt tgattggaat atgatgttac tgtaactaaa gcaaagtttg    36900

gattcctgta aaaagactta gcatttctcc atagaaaggc atatgtactt ttagataatt    36960

ctccatgatc ctaatctgtt atctcacaag taaagaattg acacttagca ttttgagatt    37020

taatatgtat tgagtggttc ttgtgctttg cccctctact cactttacat tataaagcat    37080

ctacataaaa tgatttgtac attatctatt gtaatgcaca caataatata atgaagatgg    37140

ggataattgc tatctccact ttttcttttc ttttcttttc ttttcttttt ttgaaacaca    37200

atctcactct gtctcccagg ctgagtgcag tggcacagtc acagttcact gcaacctcca    37260

tccccagggg ctcaagcaaa catcctgtct cagcctcttg agtagctgag atccactccc    37320

ctcggcctcc caaagtgctg ggattatagg catgagccat cacacctggc cttccacttt    37380

ttcaatgagg aaaccgtggt ttagagaagt aaagacatgt tatcacatgc aacaagaaaa    37440

aaacagaact gcaattcaaa tcaggttctt tctcatagtt cttaatacca tcctatagtc    37500

ctcaaaccaa aggttccctc ttgcttgact ttgagatgat gtatagaatc actcttgaaa    37560

taaaataaat attttattta atttttttct ttttcccaga aaagtaatct agtattttgt    37620

atcaatcaaa aacttctatt ttgaaaatac aagcattcct agttctataa aatatcaaca    37680

tatgtaaagt ctcctaaaag ctttgggttt ttatatgtga agcctttact tctgttttct    37740

ttttgaaata aaacattgat tagaattcta aataggttat cacaaatcta taattttttt    37800

cctataaaac aagcaaagta tatgacaaaa aaatcggtgc tcttttttca cctcaccaag    37860

aaaattagtg taattatttc atatgaataa gactttttac ctgcactaca ttatttagtt    37920

aattttacag gctctagaaa gatgttatgc aagagaagac atttcaatta atctgatgtt    37980

gaaagaatgc tagttttaaa actcaatgca ctctatgtgc taaaaacgtt tttgcagcat    38040

gaaggtaggg atggacaggg acatgtttgc ctgagttctc cagggaagct ttggtggtgg    38100

atgtatgcaa agggcataat ctgtggtttc caaagttgaa tatgcacacc taagaacaat    38160

gctggaagag ctttgtcttc attcttatct ttaaaagttt caattttatt caagatcaag    38220

gtaatgatag atttaaaaaa taatgataaa ataaaaaata gtttcaattt tgtgtatatt    38280

tttaaatgca tatgttttac actgcatgtg tagattgttt ataatttagc aagcatataa    38340

attcatttat tgggagatct tttattatta ttggtattgc tattattgag ctggtaaggg    38400

tgatgatcaa aaataattgg agactctatt ctaaacgtga ggtagaaaat tttctctgac    38460

tctaatggtt taatctttaa aaaacagttt aagccacact ataattaaag ccataatgtt    38520

tgtaacactt aattataagg atggaaaact tggtcctata gatattatca ccttaaggaa    38580

aggcaggaaa gctaactgca gtagttgacc attggcacat tgaaggggtc atgactggcc    38640

tgcagtgtca aaaagtgacc aaacagggac atctccatat ggcattcatt gactagattg    38700

gttctattac tgattgaagt catttgtgtt ttttgtacaa actttaaata gcccaaagat    38760

tctaaacgat tttaaagtaa atgcaatata ttattagtat tatatagtct atacatacgt    38820

gctgatgtgt ttgtgcgctt ttctctattt atagggcatc ataatttctc aaatataagg    38880

tataatataa tcaggacaag acttgggaac aacatagtat acataataat cacatagtta    38940

ttattttgac aaacatttat gccacacatg cagaaacaca agtctgcaac cctccctatg    39000

tattgacatt attctgcaag tatgcttaca aaacaatata agagagatca gaatatccta    39060

gtattcttaa ggttaaaacc gaaacctttc ttgtatttcc tgaatgaaat gacagattaa    39120

tgttattgat gaaatgaata tggcttggct tccttgagac acaggctgtt agtaaaaaag    39180

caattaagaa aataataaag aaatgaaaca gcaattcctc ttcctttttc ctttcttctg    39240

tactgtgtca tagcaaaagt aatataatag caactaatta taggaaatct cccagacttt    39300

gtaattggat ctttcatttt ttcccacagc aactgtgaac taagaattta ttcacagagc    39360

agctgtagtt tgtttccagt aactcttagc agtgtctctt tgtggagtct taaagagacc    39420

catgtacata tttaggcata ttggctaaac tagtgccttt taaaacatct gcaggtctat    39480

tgttgccaat tctttcattg tcttctatca aattaacttt tcttagacgg tataaagtgg    39540

gagaagccac tgaactcaaa gctcaaagcc tgacttctgg tcatagcttc aatgtttcct    39600

taaacatgac ttggtaacaa gcaccaaact ttgtaaatct caatgtcacc tttggtaaga    39660

aaaatgaaag gaatctttgc agtttatatt ttagagcatt gctatatgtg aaagagctgt    39720

gaaaattata aaccagtgta actcaccatg tcattatata gatatgtcta agttattctt    39780

gaatgtgaaa tttccatttg cttgacaaat gtcactctat tacatacatg atagttaaaa    39840

gcatcttatt ttccatttgt tccccagccc agttttcaac ttttcttcta aaaaggtaag    39900

gtcaattaag agatatttcc aaaggaaata gttctttaga aaatacttta gtatatcaat    39960

gcacataata atacaaagaa atgcagttat aaaaataaaa tatagaataa atacacagct    40020

accatattct tggcatatat ttgtacatga agaaataaac ttcaaagcca ggcaggacgg    40080

ctcatgcctg caatcccagc actttgggag gctgaggtgg gtggatcact tgagcccagg    40140

agttcaagac cagccggggc aacatagtaa gaccccattt ctataaaaaa tagacaaaac    40200

ttagccgggt gttgtggcgc ctgcctgcag tcctagctac ttgagaggct gaggtgggag    40260

ggtcacttga atcccagagg tggaggctgc agtgagctgt caatgcacta ctgcactaca    40320

gcctgggtga cacagaaata cactatcaaa aaagaaagaa gagaaaggaa agaaagaaag    40380

aaaaagaaag aaagaaagaa agaaagaaag aaagaaagaa agaaagaaag aaagaaagaa    40440

agaaagggaa agaaaagaaa ggagagaggg aaggaaggaa aagaaagaaa gaaagaaaaa    40500

aagaaagaga aagaaagaaa acgttgtgat atgattagag gactaagtct taacgattag    40560

aagcctgatt tttaaaaaat tcaaaaacca agaatcagta gtagtagttg agaaagtaaa    40620

actgagtgaa aagtagtttt gcaatcaatg tggaaacact atttggtaaa atgcacttgt    40680

acttgacctt caagtaatag atatgtcaat gttaaaatgg catgttttga aagaaaaccc    40740

atgtcaaata gtcgatataa attatagatt atatttctca gataattata aattataaaa    40800

tttctgagta cattcttccc aagatgtgtt atttgaggct tttgtcttca ctcattttca    40860

ttaaggagac tggtttccca tttgttttct cttttctttg ttttcaagct gtaatactgt    40920

agagtaaacc ctagccaggt gcttgtcctg ccttacttca tcccctcttt ctaacagact    40980

acccgtgtaa cttcctcacc agtgaaatag gagacatagt tcctgaggtt aaatcattta    41040

ctcaggttca tacaagagtg gtaaagccaa catttggact tataatttcc tacaatatgc    41100

tacctctcta gatagtagaa ttaaatttca aagagaaatg tcaggagaaa ttccatattc    41160

tacactaagg ttctcatcta ttttattttc caccatatta ttacatagaa gttatttaat    41220

ttaaaagtct gattttaagg taacctttat actattaact ctcctccttg aagtgctaca    41280

tttacaagta attaacaaat actgtttgag caagcacttg ttcaggtgcc agggactcca    41340

gtttttgtta atttaaatat agatgcttga tatcatttat tggggtgaaa gagaataaaa    41400

caccttctca cccaccttcc taaattcatt atagttaaca gagggagtct ataaaaatac    41460

taggacatag ggactcatta cattctaaca aaattctaag aacatgcatg tctttcccca    41520

ggcatttagc ttcccctccc tcctcctatt ttttcatatc ttaaagtaag atctaaatta    41580

aaaatttaga aattcccaaa ttatgttgct gttgataaaa ggccactaca tgtgaaatca    41640

gccttttctg tgatacatta tatatcagag agtcagctat tacttgtttg tgcctttaag    41700

aaagttaaga ccaacttacc tgtcatttta aatttgattt ccgaagagca gtgtgccaga    41760

aatttggctt aaacagacca acaaagcgtg gcttctaggt gttcctgatg ggcaggcttt    41820

tttcaattaa cttcctgggg attgttttat ttaattacaa ggacagttta ccagataaac    41880

tactcactga ttgaatttct aaactcaagt ctgctgaata aagccaaatg agtcatcgat    41940

aaaaattcag atgccaagac ctttgcaaca ggtacatact ctaagccatg tatttctgca    42000

ttttaaagtt ttaaaacatc cttcctctaa tgttatcttt tttttctata ctggcctggg    42060

gagtaacaga tcttagttca aatcctggct ctgctacaca cagctgtgtt accttgagca    42120

aagtatctaa ttccatagat aacgctttag tttccttagt tgtgaattga aaaattcagt    42180

gaacccaagt tgagacgcat tctacaaaat aactgatttg tattctgccc aattgtcagg    42240

tcacgaaaga aaagaaaaca attgaagttc tgttgcagat aaaaagagac taatgaggta    42300

taacaactaa atgcaataaa aaatgatgta atttaagtaa gatttgcaat tcagatagta    42360

atatcatact ggtgttaatt ttcttgatta ctatggttat ataattgtta acattatagg    42420

aagtggggca gggggtacaa gggaatattt agtactattt ttgctccttt cctataatta    42480

gctcacaata aaaaatttaa aaaacaaata aaagttatgg agagaggaga agccaacaaa    42540

tagcataagt atagaactgt ttttgtacac atgggcgtta gacagatagt aatagtaata    42600

tcttgtataa ttttaatata aagagcaccg aaagagaaaa aaaaataagc cctaaatcaa    42660

tgccgagggt gtcatctttc tttggaaccc ccttaatgca gtgactcctg taagtgggca    42720

tgtccctttc atacagagtt gcagttgtta caattgataa gggttcatgt gagacaagca    42780

attttgaagc agggcaactc ccacaactgc tcaatgtgga cctcatctcc ttgtatttgc    42840

atagatatgc tttgctgcat ggattgctgc aaaattgctg aaaagactcc catacaagga    42900

gaatgcctgg cactactcct ccgtttgaaa gctctggttt ctctcttgta tcctgggaag    42960

agtgctgcca agtagtccat agacctcttc ttatttcctt aacttgctgt gtacattttg    43020

aagcatttat gtgtcagttt atttaactcc ccctgcctaa taatgataat aacaataata    43080

gaggtatgta ttgagttctt attggttcaa gtatgattct agagtgttta tatgcattaa    43140

ctcatttaaa tattcaaaat ccttttcata ctcattttac cgatgagtaa actgagatac    43200

acagttaagt aacttaacta aggtgaccta gcttttcagt gttggagtct ggattaaaaa    43260

gaaggtagcc tggcttgcac ttttcagcct ttagaaatat acatacgacc atatccatct    43320

gctgaattcc aactcaactt tccttctttc ctataccagc tcaaaccaat ttctaacccc    43380

ttgtgtttcc aaggtacttt taaaatactt ccattcaagc tgttttgcca tgttttgtac    43440

tatgatcatt tatgtacacg tctttcttaa aaaccattag cctcttggga ctaggaatat    43500

tcctgggcaa tgtcaaaata ctctttatat gctggtgtct ccaaagttac tatttccaac    43560

ccagcctccc attttaagtt ccagagtaac atggttagct acttattgga cctgtctact    43620

ttgtgtctcc caggcatctc aaacacagga tgtccaaaat tggatttatc atttttcttc    43680

cctgttcttt aagcctcatc ctcctagttt cctctcataa gaaatcactg gagtattaac    43740

ttggcaggcc aagtcagata cctgaaagta atcttggatg ctcatctcac ttctggaatc    43800

ccgagttcaa ctgccatttc cagcctttca ttatctttca aatgtaacca catacctata    43860

cctcaatatg tttccatacc cccaccaatc atatcagttt tattcacttg gtaaccgatc    43920

tttctgctgt aaatttaccc tctagactat gtgaaaagtg agttttacaa aatatggact    43980

tgatcatttt cctgcttaat ctcttcaaaa tcatacatct accttcctct ggaccccctt    44040

tctctccact ttctttgtta aggaaatagt cccttaaaaa taatgaaaat aatcagtcaa    44100

tattttccaa tgagttagtg tcaatgccca gggtctacaa ctcagcacag gtatccttta    44160

ttaagtgtac tataaaagga gtaccaaagc ttagagctta atcactggat gacactggaa    44220

tgattacaac tgaaaacagt tagtgattag ccttggtgga tatattggaa gcctagaata    44280

cctctcagaa gatatagaac taaaaaccca gccagcctct caggccgttt acagtgtaaa    44340

caaagcaatt agagccaaag gagcaagtaa gttctaagga ccctggcatt gttaaatgga    44400

aaaagcctcc aggtgaaatt gtggtctaag cataggtttc tcaacctcag cttaatcgat    44460

tttgggggca ttcctatagg aactttagca gcctctctgt cctctaccca ccaggtgtcc    44520

atagcaagca cccttcttcc tccatgttcc catgagggag gagagtccga tatctataca    44580

gtatatgaaa ctaggaaatg tatgtaatga ttttgtcctg caccctttat tggctttgtc    44640

aagacagcct aaatttcctg tatcttagct tttttcaata aattacaaaa atttgacagt    44700

tggagccatt tttctgcgac agtaattggt gattaaatcg cttaaatgcc aacattagcc    44760

aaaatgttta cctctacaaa tgagaatctt tacaatccct atcctctttc tagcaggttt    44820

ggctaaggga acaccaaaag cacaggcaga aaattacaat tacaattgtc cctcagtatc    44880

agtgagggat tggttctagg acctcatgag atactgaaat ctggagatgc tcaagttctt    44940

tacataaaat ggtgtaacat ttgcacataa tctattcaca tcctaccgta tactttaaat    45000

catctctaga ttacttataa tacctaatcc aatgtaattg ttgttattct gcattcatta    45060

ggaaataatg acaagaaaaa aaactctgta catgctcaga ctgtgcttat ttttcatatt    45120

caagaaagga aaagaatggt ctttaagccc aagtttcaag ttgtgaacag gtaatcatca    45180

ttatttatca ttaactcaga atcagtacac aggctctgaa aatcagctaa atctgtgaaa    45240

ttctcattcc agtggccatg tttctgaaaa taaaccagtc aataactgcc tcactccagt    45300

aactatgctt ctgaaagtta gcaagtgaag gccagtccaa gcttttgaaa gtctgctaat    45360

gataaactcc cagtcccgaa catcaccctg tcagtgcctg cccctatggt gctagagaac    45420

agccaatcag taagtgtccc actctagtga ccatgtttcc aaaatttaga aggtcaacgg    45480

cagtcttact ccagtgtcca cactaacaca gctggaagtc cttgagtctc taaacactct    45540

gcacatttcc ccaaacctta tataatgtca gctgtggctt tgttccagga acttatctct    45600

cacaaataca gttctctctt gctggcaaac agaacgttta gatttttggc atccaatatt    45660

tagttcaatt tactgtaagt tcacaagttt gcaatccttt cattggctca actcttgttt    45720

atgtttagtt atgagtttgt acctgtgagt gactgacagt gacaaagctg tgagattatc    45780

aaattcaatc ttttcaattc ctgggtcaat tactaatatc cattttttat ttgtgtagaa    45840

gtaaactcaa aaatgtcaaa atgcaagtaa gttttgtgat aaattttatg aacaatggat    45900

gtgcattaaa caaagaaaaa ctccttttga agctctttgt gcagcataca attgtttagc    45960

taatattgaa aatggtgaaa acttggatgt aagccagcaa atactaacag ctaagcaaat    46020

agatgtatga tttcctcaac ttgtaccaaa gaaagtaata aaatcacatc ttattgaaag    46080

aaattcagat gaagaagata aaataattgc agcacaagtt gtcttccact ttgtatatca    46140

tacaaggttt taagctcaca tgacttaatt tgaattgtgc tacaagtatt ttttaatgca    46200

aaattgtaag taaattttct agtgctatag gacaaaatct actgccgtaa taaaaattag    46260

aataactcca tttactgtta cagagattac cacagctcaa atgttttact tttttatggc    46320

atagccatga atgcaagtaa tcacaatttg ggggaaaaat tcctttactc gtataataat    46380

tttctcataa aaagacttgc ttacaaggct attgtaacac gccttccaga tgagtcttca    46440

gaaacaacaa gaaattgttg cagagaccct atgattgagt tagtagtcat aaaaattata    46500

cttattttgt ggaggtaata caaatataaa ttggtggata tttgcataaa ggtgtgatat    46560

ttattgaaag ttaaagcaaa gtataaatgg gactatgaac agtgttgcct cttctgccat    46620

attctacatg acgctgctca aacagcatct gatatcagta aagtaattgc cagtaaagaa    46680

attgtcaaga aattattcta tttcagcatt tattctgttc agactctact aatgaagaat    46740

ttttgtaatt ttgttggcat tcgttatttt cagttctttc acattttaaa attcactggc    46800

tctctttaat agatgcagtt gagagaattc ttagtttatt taaagcaccg aaatcatact    46860

ttaattctga agaaaaggtc tcacaaattc ttgctgactt ttaaaataac ccattgagta    46920

aagactactt atttcttgct catagcattc catatctttt agcaatagga ttatgcaatt    46980

tgaaagaaga gtaaacattg ttaattgatg ccctccattg cttacaaaga gttgttgaat    47040

gtattaaaga taaaatggat gaaaagttta tcccttgtat gccaaggctg ttttaagagg    47100

aacaacacaa cttagggaca gggaaaaagt ccgtattgaa gtggataatt atttttacat    47160

ttgtcatgag tatattttga aatgtatttt atcccttgaa gaatttgatc ctttaatgga    47220

acaggagaaa ttatatgcac tcaaagaagg gaataaaaat tcatgacaat gttctgtttt    47280

gtcagtggaa aatattttta aaagttgtag atcaaaatat gcaatctaat cctgaaaaat    47340

aaaaaaaaac aagttatgtc atgaaatatg gtattgtgtt ctttagcaaa agagtaagtc    47400

ccagagttaa ctttaagtca atacatgttc agaagtccag cttataaggc taacactgaa    47460

catgttcaat aagctggact tataagctgg acttcacgat gttctcatta atgaatgttg    47520

aatggagaaa agagaaaatt tggatgtgac cactatggaa gacatgttac attgtagggg    47580

gaacataggc tttaactata aggaatttta taagtcaact ctgcaaaaca aggagctgtt    47640

aatgaaagcc aatcatcgag gaaattttca gaaaagaaat ctctaattta catactgatc    47700

atttatttta gataaacaat tagtaaattt taagattaag actgttctgt aaaaacattt    47760

ccatttatgg tcagaatatg tatacacaat gataaataat tcaaatttaa ctgactgtgt    47820

attctttttg ctaactctgg taactccacc tggaggtagg gaagaattat cctgttgagg    47880

accactggtt tagaccaaga taaaatatta tagcattctt acaattatta tttaataact    47940

ttattatact atttatattt cttaaaataa atatattctt ggatttgcca tattttcttg    48000

aggacaaaaa tatttttgaa atataataaa atataatttt aaaagaaaat ttaattttaa    48060

aatattttag agtattgaaa gtttgtttta ttgtagtaag ttagcatcat caggttgctt    48120

atggaaggct tatggtcctg caagattaaa taatggcttg gttttgttat atttacatct    48180

gtgatttcat ttttaaaaac taagaataat agtgtagaag atataaaagc agtgtgtata    48240

tttaaagtga attttaagga cggacttagt ccaaaataaa agttttggac tgtggatatt    48300

gcagaaatat tattaataaa gataatgagc aaaatcatca tatctatttt atagtataag    48360

aagtaatatg ataggaacaa tattgaaatg gattctgcat ttacagactg cattatgttt    48420

cttttaaatc actacttctg aggtcaagtg attaattttc aagtgattca gaagaaatgc    48480

tttaatcact tagcaaaact gtcatagcca aaaggagctt gttttggtca taacctagtt    48540

cccacaaagt gagccaaaag taatttctca tattaagcaa agatattgat tacaagcaag    48600

agaaacaaac actggctgtc ccaagccaaa tggagattta ttggaagttg ttgggtactc    48660

atgcattcat tggaaggctt tgggaaacta gagcagctgt ataggaaaat gagctgacaa    48720

aagggaaatc tagaggctgt ttggcagacc cagctggcta gactactggt cactgctgcc    48780

acacaggatt ctactatagc tgtacataga cccagcacaa gggaatttca ataaaatctt    48840

cctttatttg gcttcattca ccaagttcaa agtaaagggc aacagaatcc atttgaataa    48900

gcttaggaga tgatggcctc accacttaaa ataacaggag tggaatggaa atatagtcac    48960

tttagtcact ttagctttcc acggcaggtg tcaaggctct gaattccatc accactacac    49020

acaatgggaa atacctgttc attctagata agaaggaaga ttggatattg gatagaaaaa    49080

aaagtagaca tataattagg tcatatcata tgacattctt tgtcattttt gactttttat    49140

attaaagtag tgatggaaag ttagtggaat atgaaacaaa agttacaagg atgagcaata    49200

aaataaacag aaattatatt aacattgagc aatgaactat aacaaagttt tgtcatacca    49260

gaagcaaaag taaaaagtat tatttctcaa agaagaagac actcatctct tatagcacta    49320

ttaaataaat tcttggattg tgtaataatc cagtttataa agaagagtga atcatatgaa    49380

tatgttgagg aaaaatatta ggatgtcttg ctcatttgcc ataaaatggc caaacatgtt    49440

gagataacaa actcttcata catcactaca ttgaggatat tgataacaga gtggttgggt    49500

gttgtcgatt tagagtatat aagattagct tctgaataag gacactgtac aggctctgat    49560

atcttacaac tcatatgtga aagaaacttg atggaggtgt tcccaaattt gacagtaata    49620

ctgaaaattt tcatgccatt accaaaaaca agttgtaaaa ctcagagaaa tttgctcaac    49680

tatcagtaat gaacatacac acactatact cagttgtggt aaaagaaaga ctaaattttt    49740

ctatcttctc cattacaaaa ttgatacaaa gtaaagggaa gatcaaagag aatgaagcca    49800

aaaatgaagg gaagtcctaa agaaatgtgt taaggagtaa attaataaaa ttttggaatt    49860

tatggtattg gttaattatt tttaatacag agacaactta tttaattttt gttctcactt    49920

ttaataaaca ttcactttta tattaatctg tcttttgtgc ctaatttgcc cttgtatttt    49980

tgcatttttt ctcaacctcc tcccccagtt gtataagcca cagatccata aaacctggat    50040

ctgtttatag gccacagtgg gttagatcag gggtttccat cccctgggcc agtgacagat    50100

actggtccat ggcctgttag gaaccaggct gcacagcagg aggtgagcag cagcccagtg    50160

aacattacca cctgagttct tcctcctgtt agatcagcct tggcattaga ctctcagaga    50220

agtgcaagct ttattgtgaa ctgcacatac gagggatcta agttgcacac tccttatgag    50280

actctaacta atgcctgatc atctgaagtg gaatagtttc gtcccaaaac ctacctcctt    50340

ccctgctgcc ctgaaaaaat tgtcttccat gaaaccagtc cttggttcca agaaggttgg    50400

ggactgctgg attgccaggt gttatcacta agagagcaaa taggtaaaat gtctggtaat    50460

atacactgga atattatgca gtagttagaa gtgcagatta gatgtattta caacaacatg    50520

aatgctaagt actttaaatc atagtgctta gtaaataaaa acaaacaatg agaaaatgta    50580

tgtaaattag agattcatgt gtacaatatt caattttcaa gaaaacagaa agatgttcat    50640

aaacacatta taatggttgc taagcatggg aatgaaaaac aggtagagtg gcagagaatg    50700

ggatatgggg gcaatggaga aaaaatatta ataaaaggag gctttgcatg gccaatgata    50760

acaattggcc acaaactggg aatttaacct ggaacttgag gttaaaaaaa tctgtagaat    50820

gcaggaactt tggttgatat tatccacaat acaagtaagt tatgatttaa cctttagaag    50880

gaaaataagc tttgtgcatc ctttaaaatt tttaattaga atagtttgaa gactagacaa    50940

gtacaggaat agaaaatcta gagagtttat gaagctatat atttcaaatt ccatcgaagg    51000

acaaagccaa agatgatttt ttttcttgtt tggaaaagtt gagagtaagt aaggacaatc    51060

agacttgatg acaaagccaa aaatgaagga gacagctcct ggatcatagc aaactgttaa    51120

cacaagaggg aggaattgta ggagatacct gtcatagtac agaccagcaa atttctactc    51180

atcttccttc cctgaccaaa atctttcttc ctaagtccaa gttaggtgcc ttttctgtgt    51240

gttctcattg ctctcatata gtaggtgtgt tgtaattgtt tacctgctgg ttttccccaa    51300

cagactgtaa gccctagagg acaaggatca aggccaccta gttagtattg tgtcccaggc    51360

acctggcacc ttaaaaatat ttgttgctct tacctccaaa caacaacaac aacccccccc    51420

caacaataac aaacaacaaa aatgggtaac aactagagat ggtagatatg ttaatttcct    51480

ttactatggt aacctttttt ttactatcta catgtatcca atagcatcat gttgtatacc    51540

ttaaatatac acaataaagt gtattttaaa atatctgttg aagagtaagt aaaatgaaat    51600

gaacctatta aaggaatatc agtataatat ttcacacatg tgaccattat tttcataact    51660

tgctgcgggg gtaaacctta aaatcaagac taccttcatt ttgttttggt aatttgaaaa    51720

gtaaggaacc gataatattt aggcattttt ttactttaat cttttgtagt ttaataaaga    51780

aaaatttcca aactacattc tgttaattgt gctagcaagt tattatgatg gcattttaaa    51840

aaattaatgc aaataataat gatgcagata atcaatttaa ttgatggctg gtcacttaag    51900

atcgctttct aattttcagt tattaaaagg tctttcaaaa taaggctact tttgtaaaaa    51960

aataattttt atactatatt gtacattaag ggaattcatg gatggtgttt tctacacaac    52020

agagaaaaaa ttttatgtaa acctgagagc aattacttta ccaattaaat cactcaaatg    52080

ttgtagacta aaataattga aagtcaaaat aagattaaag aaaatcagtt ttcatataca    52140

aataatggta agggattcaa gaaaataaaa attggactta atgcatttta acctatatag    52200

ttttgaaaac cataaaacat aaaccttatt gctttgtgta gtcatttttc acctttgtag    52260

agtccatttt tccttacatg taaacaggcg cctattctaa tattcttcat ttcttgctgt    52320

gtttccattc tttttgtcta agatcttttc cttctgccta aagtacttcc tttagtgtat    52380

attttagtac aatgattaat tctctcaact tgagttttca gaaaaagaag tttttaaaaa    52440

cattttacgt tcatcttttt aacttttcat taagtataac atacttaaat aaaaatgcat    52500

atatcatgtt ctcgcttata agtgagacac atagagggga aaaacacaca ctggaacctt    52560

tcaaatacag tagagggtgg gaggaggcag aagatcagga aaaataacca atgagtacta    52620

ggtctaatac ctgggtgatg aaataagctg taaaacaaac ccccatgaca caagtttacc    52680

tatgtaacaa acctggactt gtactcctga acttaaaata aaagttaaaa aaaaaatgca    52740

tatatcctaa aaatatagtt tgatgaattc ttcacaaacg aaacaaacca tgtaaccaat    52800

actgggatga aaacacagaa ttccttcact ctagaataat attttcactc tctctaatgt    52860

tccagagtgt cagggactac aaaggctaca aaaccaaatg acaggtctgc tttgttccaa    52920

gcaatgttac aggctaaaga tacactgctt gtaggatttc atactcttaa aagttcccag    52980

gtacataaaa ttctactaat tagttaaatg aagctgtgta ttcatggaca atagttaaat    53040

tgtgacacag atgagtgtac ctagcacctt gttagagaaa gctccttagt atcaatgaga    53100

tgtgaaggac atctaagagt tatcagggct agaggtctgg ggagagttat cctggctcat    53160

gctagtcttt tagtgaaatg gcctggacaa attcatagtg aagatgggca gtcaattgat    53220

aagattatat tatatttgac tgtttatttc taataagatt ataaaaagat tataaagtta    53280

aaagcaaatt gaggtgttgt agtgaggaaa gaggattgta tagattcata atggctggct    53340

caattccagt gtttttactc tacttaagtg tatagatttg gttaattttt aaaatttcag    53400

gtaacaaata atatggtcat cattgaaatc cctaaatata ataaattaca accattgttt    53460

ttactgaatc tagactaggg gaagagtaag ataaaacaag ataagtagaa tgttggcaat    53520

ttaaaaaatt gtgccaggct cagtggttga tgcctgtaac cccagcactt tgggaggcca    53580

aggagggcag atcacttgag cccaggagtt caagacgagc ctgggcaaca tggtgagacc    53640

ttgtctctac aaaaaatgct ttaaaaaatt agcccagcat ggtggcacgc acctgtggtc    53700

ccagctactt gggaaggtgg gaggtcgctt gagtgcacga ggatgatgct ccagtgagcc    53760

gtgatcacag tattgcactg caacctgggc aacagagtga gtgagacctt gtgtttataa    53820

gaaaatttat acctttcaaa aatttaaact catactttct gcccatatta cagctgcctc    53880

cttctgtggt ataaacgcaa tattaaatat tgtgtttatt tttatcaaaa taagacagaa    53940

attctcaaga cagaaaatga aaagttttgt caaggggttt cacagacctt tcattgaatt    54000

ttaattgcaa tgctaaacaa tatttgaaga taacccatag tggtcccagt cttcagcctg    54060

aagtcaagaa cctttagtta tctgaatgtt ctcaagctcc aagactccct aggatgttat    54120

ttaagcaaag tgcaggattt ccaaacacta gtgattaata tatgacatct gcttactaca    54180

gcactgttgt gcagccacaa aatctttcag aaaagttcac aataactatg gcttactttg    54240

ataaagaata gtcagtagga tggttagtct aatatgctct cataaaaaaa gaaaagtatt    54300

atgaggtggt gccaggacct tgggtcctat ttggctattt ctccaaggat ctctcaatgg    54360

taagatcatc atatatctaa gcttgcctag aacagtccaa ggtcattcct gctgtcttgg    54420

tattttctgt gttgtgtagc atttattctt gacacaaaat cctggcttgg aacataaatg    54480

ctgtagacat cctgccaagg attgaatcaa atttataagt gtaaccctga cagctagggt    54540

agagctgtct atttccttcc tccaaagatg ttatcaggta tttagattag taaaatgaga    54600

aatactgaga tacccttata attcaaggag cacataggaa tggatataga cttggtttaa    54660

gtattatttt tcccctgtat tctccagatt caatcgtttc gcacctttga ctttcttatc    54720

taaactgtag agctattcaa tgactaaatt gtacttctta ttgtctttga atgtttcagc    54780

tttatcttgt tattgacata tagaattttt attatcttga tatttcactt attcaatcgg    54840

aggccaggtg taggaaggac tccaatattt tcttggtgcc aagacataga acagagtttt    54900

cagatccatc tggaaatttt tctgttttca tgggagaagg cctataagag ttcatactgg    54960

aaggaaacat tgcctctctc atctctcctg atgacatatt tctcttttat catgggaagt    55020

cttatgttat gagtagataa gttatgaagg tgatgttatc gaacatagga gagtaattta    55080

aaatattatt gacaaaaggg gcttttgtag ttataaacca gggttaagcg tatccttgtc    55140

agccagagtg gagctgtatt tttgtcttgc tctgatgatg ttatcaggtg ttcagagctc    55200

agtaaaatga gaatctcaga gtcaaataca tttcttttat ctctatgtta cctcacagtt    55260

cctaaagtaa cacagaaatc aaaagtcagc cttttgtacc ttaacggcat cattaagatg    55320

gatatgtaat aaagcttcaa tttaacaact taaaagatat ttagtatgct taccatggtt    55380

gagggagtta aattgtactt attctaaaag aaaatacaca cagattccct cataagtgta    55440

tttttttagc ctattataat aagacataat gactctcaag tataattagg actcagacat    55500

tgtgactcca gtttagttct atgtttataa gtcataagct cattcctgac ccaggagagt    55560

gcatttatag aaaattatcc tcccaggcat gattacttta agaaaactga tcagcatttc    55620

taatggatct cctattgatc aaagcaatgc tattttgtac tgtgtaaaat atgtattttt    55680

aatgtattaa ttgtaattca ttttaattaa aagtggttca aatttatgtc tattatcact    55740

taggtatatt atagataata tagataatgg caatgcattt acctgataaa ttcaaattca    55800

ctgagctatt attaccttta tttaatatta gaataattct acatctgtga tttccttttg    55860

cttaaacttt tgtcttggaa tagatttatg gaaaaatggt gcagatagta aggacagttt    55920

caatataccc cacatccagt ttcccctgtt attaacagtt tatattagta tggcgcattt    55980

gtcacaatta acaaaaccat gtgatacatc attattatta acaaatgccc ttaccctatt    56040

cagagttcct tagtttttca ctaatttcct ttttctcttt caagatctca cccaggctac    56100

cacattacat ttaaccatca taccatcata tcaccttaag catctctagg ctgtcgcaat    56160

ttctcaggct ttccttgttt ttgatgatgt tgatactttg agtgagtata ggttaggtat    56220

tttgtagaat gttcctgaat tggtatttgt ctgatatttt tctcatggtt agattaaggc    56280

tataagtttt gggaaggaag atcacatatg taaaaggcca ttctcatcac atagtatcaa    56340

tggtacacat tgtcaatgag ttatcgttgt tgatgttaac tatgatttaa ataaactttt    56400

taggttctca tgttctgatt ctatggtgcc ttgagaatgc tttaaaaatt aatggtactt    56460

cagtcaagat tttacctgca ggaaaaaatc actatgtgtt tctagagaag tgacattttc    56520

aaagcagtat ttcattttac aacagttagc atcaataaaa atgtattttt tatttatctt    56580

tacatttgtc cactgtctta aatatttata ctgactcaat ctcattcaga ttttggcaga    56640

tcttccaaat gattaattgg accaatttta aataaataaa tttatttatt tatttgagat    56700

ggagtcccgc tctctggttc aggctggagt gcagtggcgc gatctcggct cactgcaacc    56760

tctgcctgct gggttcaagt aattctcctg cctcagcctc ctgagtagct gagattgcag    56820

gcgcccacac cacacctggc taattgttgt aattttatcg aaataagatt aagttattta    56880

caggtaagag gctcagtgat ggaatgcaaa acagcctgaa attattatag agttgtgagc    56940

atgtagctat tttcctgctc cttgaaataa gaaaatatag agttgtgagc gtgtagctat    57000

tttcctgctc cttgaaataa gaaaatgtca tatcatagtc cctctaatca agattaaaga    57060

aacaaacaag taaacactac ttgctttcta caagagatgt caaaagttat caaaggaaac    57120

atactgttta aaggaattat ctgggagata tttttaagag aataacttat tctcttaaat    57180

aaatatagct ttcatatata agataaacat taattattac aaaagcacaa catattacaa    57240

aattatatgg acataatatg cacatactct aactgagcca caatagaatt ggtgccctga    57300

cactaataaa tcatttggga actgcagttt ggagtattta gtacctgtta tgtggccaag    57360

aaggtaatag aggccactga gaccttttcc agtctaatat aatgggcaca actcacattt    57420

tttcctttta gttattaggt aaaaattagt gttggtgttt acttcagtga ttttttagag    57480

gatttacaat ttttactgtg aacacttagg gaaacccact tcccacctca tcctatagat    57540

tttccctatg tgaagggttt tcatagtacc ttggggatga aaggaagtcc cccaaataat    57600

tttcctgatg tctgcttcca atatttgact tcaagaatac cgttttccaa atagtatgtt    57660

cagagccata ccaggcacac agagtctcta aaactctgga gagactgtaa tatttctttg    57720

cttgaaggaa gggatcattc ttgtattctg ttcagagatt acattaatga tatttaaatg    57780

tttctcagaa gataaaccaa gtgttggaat ttatttgctt ttgaccctgt tcagcaatat    57840

tcaatgaata aaaaagaaaa aagtcttaat gatagttctt gagccacatg actttgtcta    57900

attaaaaaat attttgcaag tcttcatata aagttcaaaa caacaaaggt gaaatgatgg    57960

gaattttctt aagaaaggaa attctgcagt gacccaatcc tttgagcaat caacagtcat    58020

tctagggata ctcttgtatt gtttaaaatt acattttaca aaataaataa tgtcctaaat    58080

gcctcaacat ttttagaatc agaaaagttg cttaactggg atgtccaaga tcatttagct    58140

agtaagtagt gaatccagta ttcaaaaccc aggctttcta gctcctgaac ttgtcctaga    58200

ctcactactc taaactaaat ctctgtttaa tattacatgc tcatatgaaa tgtttcatgt    58260

ttaaaaggcc aatacattcc cataaatgga aatatcctca tttaatataa ttaatatatt    58320

ttaattatgg aagcatgata aaattatcca aagcaaggaa ttaaaataga aggatgagac    58380

aagttaataa tcttatgagc tccatgaata cgtgttcatt atgtgcaaaa ctcttcctgt    58440

taagcacttt atatacagtt aaccatcaca atctaaacca ctcttcggag catgattatt    58500

aactcaattt ttcaaactag gaatcttagg ctcagagagg ttatgtcatc tccacagggt    58560

caacagctct aaaatgtgga gcacaaattg taatgggaaa ggccaagatg attattgacc    58620

tgtgagccac tgaaaccagt gtgaattgtt ctgtatggaa tagaagtaca cttcatgata    58680

tatattgtaa ctgttgctga aggattttat tcattttaca ttggatcaaa tggaaatcga    58740

gctgtatatt aaagatttta caaaagctcc aaattaagaa gaaactatag aaactcaaat    58800

aaaatgaaat tttttttaaa aaagtgtttt ctaagtagtg tttcataaag taatacaaat    58860

ttttagttat taggctgata aaataaatct atttctttta gtatctttgt cctttctttt    58920

tgaatgttgt tacacattcc tgaaagttgg aagatcagcg ttttaaaata aatgctagga    58980

aagacctaat gtaactcttg attattttac agcatcaaga gttcttcctt cttcttgctt    59040

attgcttgac aacagattga ctgaggatgc tttagagctg acaggtttgg aggatgaggg    59100

atgagtgagt atgagcaaaa ctctgaggag gagcactgca tgcctcaaaa gaacttggag    59160

agaataagag ttaccaaaaa aaaaaaaaaa aaaagatttt gccaggctat aattggaatg    59220

aagtgatata agtgacatga atgatgctta aaatgttgag aattaaaaag taaatattaa    59280

aacattgaaa aacttttttt tacccttttt ggtttatcat cttccttctc tccttcaact    59340

tccatttttt tcattcagtt tttcccctca ttccaactct tctttcttta attgaacata    59400

atagagactc ggagttcaaa atatgtgttg tttctattga attgatagat tttttttttt    59460

tttttgagac agggtctctg tctgtcatcc aagctggacc gcagtggtgt gatcatggct    59520

cactgcagac tcaacctccc caggctcagg tgatcctccc accttagcta ctctcaagca    59580

gctgagacta caggtgcaca gctccatgcc tggctaattt ttgtactttt cctagagaca    59640

gggtgtcact gtgttgccca tgctgttctt gaactcctgc cctcaagtga ttcacccgcc    59700

ttggcctccg aaaatgttgg aattacaggc acgagccact gtgcctggtc tattgaatgg    59760

aatttatgtt tatcctttcc aattttaaaa tagttaactt taaagttgtg tattttacat    59820

tcattgtctt caaaccaaac aaaatccaaa aacttttcta ctttttgaat tgaatttttt    59880

ctctcctttt gaataataaa acctggtcat tgatgtatgt gtactcatct gatatttttg    59940

atttaacaaa atcaaatgga gggttcacgt tagtatttta tgctttttaa aagtagacat    60000

gcttatgctc ttccctaaaa cttttatttc agcattactt agataagccc tggcatctgt    60060

atttttttag gttacacaga tgattttttt gtataccctg gtcaatagcc acagtggagt    60120

atacctgcat tctgatatat acactcttga caaccataga gacaaatgat acttagctgc    60180

atttttaaca ttacctaaca taagtgaaag ggattttaaa acagtagtat tttggaaaac    60240

agcagataat aaaacattaa ttttgtgttg tgggttattg gtattaagta tcatgtaatg    60300

cccacatctc aaagctcact atggaagaat tggtgtcaga taataggaag attgatattg    60360

ttgaaaacca tgcattcagc aagccagcca ttggtagcac ccaatgaagt gttcagtatt    60420

catctaagca gagaaagtag aagacacaat ctttactgta actttgagtg tttgcagtgt    60480

gtcagatggt cccttgaaga agaaatatta ataaaaatga attgcaaatt gtctccaatt    60540

tacctgaaag agatcaaaat aatgtatcta aatatatggt gtttgaaagg tgtagagtca    60600

gtccatattt ttcaagccca gtgaaggtaa cagaacagtt tctacttaag cagctgtttg    60660

ttggtttctt tggctcaaga gagaggtata atatcttctt ttattttaca gctttttaat    60720

cataataata actattataa aattaacaaa tgcacatggt aactaattca aacaattttt    60780

gctttatccc tttaaagcca ttatctaggg aataatcact tcccgctttt ttaaaaaaaa    60840

gtttttctga tattttcctt tttatctcta aataatatgc ttatgtctca tttttatttc    60900

atcaacttat gtaatgtttt ctaactttct aatttgaaaa tgaggaattt attttattta    60960

tgtaaacttt tctctttctg ccccattctc aaattccaag cagttatgtt ttcatttcta    61020

agtaattcta tgggttggat ttataccttt aaatggaata tacctgaacc tctatttctt    61080

gttacttaaa ctttagccag gatgcactaa ctgccttcaa tgtaagataa ggggtcagct    61140

ctccaacttt tccctcacca ctaatccccc tctacctctc aatttttgta agctattcca    61200

ttacttttac actgataata tttaacacat atatgtgtat atcttgtctt tgtgtaaata    61260

aagttctata attgtactta cattttatat atgctttggt aattggcaca tttgtgagat    61320

gattaactga tacaatttaa caatattata attatgtatg tatttttcat tttaaaacaa    61380

gtaacatggt ttgatctaga ggaggaattt aaacctctca ttcaaactct gctacttgaa    61440

gaacacatca aactcaagtg gatcctctct gcttcaattc taccagttgt tcaagttcat    61500

gcctcatttt gaattgattc ctatttggac aatatggcta tttacacgtt ctaaagaaac    61560

aaattccctt tgcttttatt cacactattt gtgaaacatc ttgtattcta tgtgttttag    61620

aagtactttt ttttttttgc tctaccttaa tccaaagtaa cttaaaaaaa aaagataaaa    61680

aggagttaaa ttttgaattt tcttatacct agaaatatat tttgtttgcc atcacacttg    61740

ataataggtt gtctgataat agaatttgat tcaaaatatt ttctctcatc acactgaaag    61800

cattgattgt gttctagtgt caattatggc taaggaaatt ttaatggcaa tctaattttc    61860

attcttttta gttagttatc ttatttttgg aagattataa aatcttgttt ctattgttaa    61920

tgctctaaac tttcacaaga atggaacttt taaattgatc ttcttttgta cttttagctt    61980

gatgactctt ggtgaatttt ctgccattac tttgtttatt atttcctatc tactatttgc    62040

tgctctcttg agactaatgt cgaacaacat ggattattct gtatcttcta agttttattt    62100

tgtacttttt taatttttaa aattctccta aaatatatag aaaaatctaa gatatagaac    62160

tccatgcatt tttacatata catattttcc catgtaacca tcacatagat caaggtatag    62220

aacgtttcta gcacctgaga atgctcactg gtgccccatt ctggtaaagt gccccttttg    62280

ggtaaagtaa aaggtaacta caattatgac ttctcctttt cagcaagcat tctactgaaa    62340

ttttttgttt cacaaagcat gacctttacc cagaattgat gttgttgttt ttggtagcct    62400

attttttttt tttaataaaa gatactctgt ctcctcaaat ttctctagga atactaactt    62460

taacttctca atatcccaca atgtttgctt ttttttttct aaagttaaaa gtttggtctg    62520

ttcatcttag tctttcaatt ttatgtttgg tagatcttca ttaccaattt attcttgata    62580

atctattaat atttatggaa gaaaggccag gttggtgttg gccaggtttg catctgtctt    62640

tatacaggtc tgtttcccag acaaatcctc tcttgaaaga gagggatgac tgaaaggtct    62700

gtgtatatac atgtatggtg tactgacagg caggctacat tttaggatgt atggatgagg    62760

agtagataag ggagtcacct ttccctcgac tccaccctgg ttctagctaa aatggacatg    62820

gataccctag gagtcctacc ttaattaatg cagatattat ccttttggtg atagcttgga    62880

gataaaccac tctgctacat atttaacata gagagggaag tgggacaatg ttttctgcaa    62940

cattattgaa taaataatcc atggattaat caacttgttt tctgatctac atcacatatt    63000

tgccatagaa atctgtgact tctctgctag aaagaaattc taacattctc agatgagtgt    63060

tctagactgt agcttctgct ttgatctcct cactagggta atcttatgat ttatgataac    63120

tttttttgtc ttcctctggt ttttagtgat attatctaac atttcgccac tgtacatctt    63180

tgtttttact gcaatggaaa tttgaaggcc agagagtgtg ataaacacat gggataagac    63240

cattttcatg aactgggagc tgacattgct ttgactggaa agatgtgtga agaaaaatag    63300

atgctagata gacaaataca tgatatgata tttggacaga catagatcca tagatggata    63360

agcatagata aaacatatct atatatatgt gtgtgtctgc atacatagaa aataagaaag    63420

agttcagaat aaatatttcc atattgattt taactatagg aaatcttaga tacaagaata    63480

acacattcat tttttaattt tagtagttgc ctaagtattc tctaatatga gattaatggt    63540

gagtgggtaa gatagtaatg agaaaacaaa agtactgcct ttatatgcaa cattgggatt    63600

tcattctaaa gaagatacaa tcatagtaat gttaataaaa gtggaaatgt agcaatatat    63660

ttttcaaaat tgtaaattaa acatgacaag aataaatatt gattgatttc attgactata    63720

taaaattagg tcaaataatt ttaaatgatt tttttcaaag tatattttct ttcttctgga    63780

tagaaaaaca tgacattttc gttgtacaaa tttgaaaagt aaagtataaa gacataaaaa    63840

taatccataa tctcttaact agggctaaac tttgttaaat gcattgtgta tttaaattaa    63900

atatcatttt aaaaattatt attaatttac atctatctgt gtgtataacc tggattccac    63960

ttattatgca ttatattttt ataattcatt taattcatta aatagtcttt gaacgctctc    64020

tttcaaagct gctcattatt tcattataca ttcattactt catttagtgt aacccttact    64080

gttaggattt tggattgatt ataatttttc aatattataa aaatattgta gtaaatatat    64140

ttatacatgt tagaggacac ctgagattac tgtctttgaa taaattccta gaaggaaaat    64200

tatttggcaa tataaacgaa ttcacgtgtt taaggctttt gatagatatt acaaaattac    64260

cctcaaaaag tttgtacact ttatttattt atttgagacg gagtctcgct ctattgccca    64320

ggctggagtg cagtggcacg atcttggctc actgcaagct ccgcctcctg ggttcacgcc    64380

attctctgcc tcagcctccc gagcagctgg gactataggc gcctgccaac atgcctggct    64440

aatttttttg tacttttagt agagacaggg tttcacagtg ttcgccaggt tggtctcgat    64500

ctcctgacct catgatctgc ctgcctgggc ctcccaaagt tctgggatta taggcgtgag    64560

ccaccgcacc cagacagtac acattattta ttactttcat ccagacaggc aacactgatt    64620

tcccctataa cctctctaat atcactatta cttttgttaa aatctttgct aatgattaat    64680

aggccaaatt tggttcccca tgtttatttt aatatttgtt tctttgatta ctagtgaggt    64740

ttgacatggt tacaagtgtt tattaaccat ttgtattttt agataattat gttttttact    64800

aaattttatg agatatatta atatctttat tcattaaagg aaaagcactt catctgtcat    64860

ttgtattgta ctttttttat tttgtggatg ccttccactt ttaaaaacct tcattgttat    64920

gagattaaat ctagcattct ttatcttttt cgattttgcc tttggtgtaa tgctttacaa    64980

gtcctctcta ctctcacatt aaataagtat tcattttcac ttttattaga atgtttgagc    65040

tttatttttc catttaaata tttactccac cagaaatctc aaatcttaaa ctaaatgcct    65100

gactaatgaa aactcctgtg gcctgtttat ccagaagact aagggaagag gaaagaagtt    65160

gtagtcacac ataggtcctg ccccatcatt gcatcttctt tgtgtgtgtt ggtgaagtgt    65220

gaggctccat ttttacttat gttgccctct gtaaccctgt cagcctatca tcttgccacc    65280

ccactggcct ggtacaataa cttccaagca aactcagatg ccaactaaag ctgctcttct    65340

tcaaagctat aaaattagta aaatgaaagg aagtttcacc tctccaaact agaggatgat    65400

gatgaaatct gatcaaggtc tcttcaactt ccatttcaca gatcatgatg ttaagcaggt    65460

gcttagtgtc ttcctttaat ttagcttgat cagggaaata ttgcccatgc atggtaccac    65520

tagcattgac caccctttgc ctctgctttt ttcatatact ttagtcattc tggagctgtg    65580

ttgagcatgt gcatgggggt tgggggagac agagacagag gagaatagga atattggaag    65640

aatcaaactg gtaatggaca tctgagttca caacatcttt gtacctagat ttctgtcaaa    65700

taattcttga aagagatggt accctccagt tgaatgtaga atctacaaaa acaccagtta    65760

ttcaagccaa cttttcttca agagccacag tatgtctaca ctgaaagtct agtgaggcaa    65820

gttatcccgt cttctcacct ttatgatttc caaaagtgtt gaggaatctc caaagcacaa    65880

gtggcaactg ctttgatttg attcattgat ttgtttcctt tttactaaat ctcttcctat    65940

tctgaggaca attttcacat attttaggat tcaaaattct taatgcatat tcatagtagt    66000

tttattaaga tataatttac acaccataaa aaatcaccat tttaaagtgt atcactcagt    66060

ggtttttagt atgttcacaa aggtatgcaa caatcatcat tatgtagttt tagaatattt    66120

ttatcacccc aaaagaagcc ccatactctt taaccattaa ccacataacc atcaataatc    66180

acttcctatt acacccagcc tctgacaaaa aatactctac attttgtttc tggggatttg    66240

cctattctgg acatttcata agatggaatc atatcgtatg tggccttttg gctctgtgtt    66300

ctttcacggg gttttcatca catccatgtt gtaacatgta cctatacttc atttgttttt    66360

attgctaaat actaattcag tgtttgaata tcccacattc ctttatccat ttattcattg    66420

gtgagtaatg aggttgtgtt tactttttgg ctagtatgaa taatgctgct gaacattcat    66480

gtaaacgttc ttgtgtggac atatgtttta aattcccttg agtctgtacc aagtagtgga    66540

attgccgagt cataacttac tctttacctt tcagaatcat cctacttttg aatgtgtata    66600

tgaaatatcc cttatttttc actacattct ttaaaaacct ttatcctaac tttggtttcc    66660

atcaaaatac aggcatactt cattttatgg ggctttactt tattgcactt caagatactg    66720

cattctttac aagttgaagg tttgtggcaa ccctgcatta agcaagtctg tcagcgtaat    66780

tttttcaaca gcatgtgctc acttcatgca tctgtgtcac actttggcaa ttctcacaat    66840

atttcaactt tgtaattgcc attatttaat tattactgta tgtgttatgg tgatctatga    66900

tcagtgatct ttgttgttac tgtggtaatt gttttggggt gctatgaacc acatccacat    66960

aagacagcaa acaatcatta aatgtgacgt gttctgtttc agcatcccta tctctctccc    67020

tttcctcagg cttccctgtt ccctgacaca caacgatgtt aaaattaggc caattagtaa    67080

cccattccca cccctaatgt tcaagtaaag gaagaattgc gcatttctca ctttaaatca    67140

gaagctagaa atgattaagc ttagtgagga aggcatgttg aaagccaaga taggccaaaa    67200

tctaggcctc ttgcactaag tacttagcca agttgtgaat gcaaaggaaa cattcttgaa    67260

ggaaatcaaa tgtgctactc cagtgaacac atgaatgata agaaaacaaa acagccttat    67320

tgcaaatata gagaaagttt tagtgatcta gatagaagat caaccagcca caacatttcc    67380

ttaagccaaa gcctaatcca cagcaaggcc ataactccaa ttgtatgaag gctgagaggt    67440

gaagaagctg gaaaaaaaag gtttgaagct ggcagacggt accccatgag attgaaggaa    67500

agaagtcact gccataacat aaaaatgcaa ggtgaaacag caagtgccaa tggagaagat    67560

gcagcaagtt attcagaaga tctagctaag atcattgata agagtggtta cattaaacaa    67620

cagatttgca atgaaggtct aacagccttc tactagaaga atatattata gctagaaagg    67680

agaagtcaat gtctggcttc aaagcttcaa cgaacaggct gactctcttg ttaggggata    67740

atgcagctgg tgactttaaa ttgaagcaaa tgctaattta tcgttcagaa aatcttagaa    67800

ttatattatt taattattca gaatattaat aattatttac tattcagaaa attacataat    67860

aattatatta tttactattc agaaaattac ataataatta tattatttac tattcagaaa    67920

attaaataat tatattcttt actattcaga aaattaaata ataactatat tatttaatta    67980

ttcagaaaat taaataataa ttatattatt taatcattca gaaaatctct taagaattat    68040

actaaatcta ctctgcctgt gctctataaa tagaacaaca aagcctggat gacagcacgt    68100

ctgtttacag catggttcac taaatatttt aggcccagtg ttgatactta tagctcagga    68160

aaaaaaaaaa agatttcttt caaaatatca ctgcctattg acaatgtgcc tggtcactca    68220

agagctctaa cggagaggta caagggcatt aatgttattt tcatgcctgc taacgctatc    68280

cattctgtag cctatgggcc aaagagtaat ttcaactttt aagtcttatt ttttaataaa    68340

tacattttat aagactatag ctgccataga tagtgattcc tctgatgggt ctgggaaaag    68400

taaattgaaa atcttctgga aaggattcac cattctagat gttattagaa cattaatgat    68460

ttgtgggagg agggcaatat acaaacatta ataggaaatt ggaatgagtt gattccaact    68520

ctcatggatg actatgagag gtttaagact tcagtgatgg aaagaactgc agatgtggtg    68580

gaaatagcaa gagaattaga attaagagat ggagcctaaa attgtgactg aattgctgcc    68640

atctcgcggt aacttgaatg gatgaggagt tgcttctgat tgataagcaa agaaagtggt    68700

ttcgtgagat ggaatcttct cctggtcaag atgttatgaa cattgttgaa gtgacagcag    68760

aggatttaga atattacata agtttagttg gtaaaacagc atcaggctgg agagtggtgc    68820

taccaaaggc attatcataa agacttttaa aagaggaaag ttgagttgaa ttgcaccaaa    68880

ggtaaatata gacgaaaaga aggggaattt aggaaaattt actcagaaaa ttgtcatttt    68940

ttactttaaa gctatgaagc gtaaacttca aatttctgag tataaagatg gttagaaggc    69000

acgaaagata agtcccgccc attgcctgac acatagtaat cccttaacaa gctgataatt    69060

ctagaacatg ttaccttttg tagttgaaac taaaaatctg tttatgttgt tattattagt    69120

ttttaatggg cctttcttgg caggcaaata gttaagtctt tatttctttg tttccatcca    69180

ggcctcttat gtgaggagct gaagaggaat taaaatatac aggatgaaaa gatggcaatg    69240

ttgcctcccc caggacctca gagctttgtc catttcacaa aacagtctct tgccctcatt    69300

gaacaacgca ttgctgaaag aaaatcaaag gaacccaaag aagaaaagaa agatgatgat    69360

gaagaagccc caaagccaag cagtgacttg gaagctggca aacagctgcc cttcatctat    69420

ggggacattc ctcccggcat ggtgtcagag cccctggagg acttggaccc ctactatgca    69480

gacaaaaagg tgagtttatt ttgacttcag tggtcagttt ctgttggctt ccttctgtat    69540

aaaaattatt ttaaattgag attagtgaaa tttagtgaat aaccatatca tgaccagaat    69600

gttaaattaa atatatatat atatatatat atatatatat atatatatat atatatagga    69660

tattcagaat ctgtactttt tcaaattttt cattgaaatt ggctctggca ttggcatact    69720

acttttaatt ttttttttta attatacttt aagttttagg gtacatgtgc acattgtgca    69780

ggttagttac atatgtatac atgtgccatg ctggtgcgct gcacccacta actggtcatc    69840

tagcattagg tatatctccc aatgctatcc ctcccccctc cccccacccc accacagtcc    69900

ctagagtgtg atattcccct tcctgtgtcc atgtgatttc attgttcaat tcccacctat    69960

gagtgagaat atgcggtgtt tggtttttta ttcttgtgat agtttactga gaatgatgat    70020

ttccaattgc atccatgtcc ctacaaagga cgtgaactca tcatttttta tggctgcata    70080

gtattccatg gtgtatatga gccacatttt cttaatccag tctatcattg ttggacattt    70140

gggttggttc caagtgtttg ctattgtgaa taatgccaca ataaacatat gtgtgcatgt    70200

gtctttatag cagcatgatt tatagtcctt tgggtatata cccagtaatg ggatggctgg    70260

gtcaaatggt atttctagtt ctagatccct gaggaatcgc cacactgact tccacaatgg    70320

ttgaactagt ttaccaccaa cagtgtaaaa gtgttcctat ttctccacat cctctccagc    70380

acctgttgtt tcctgacttt ttaatgattg ccattctaac tggtgtgaga tggtatctca    70440

ttgtggtttt gatttgcatt tctctgatgg ccagtgatga tgagcatttt ttcatgtgtt    70500

ttttggctgc ataaatgtct tcttttgaga agtgtctgtt catgtccttt gcccactttt    70560

tgatggggtt gtttgttttt ttcttgtaaa tttgtttgag ttcattgtag attctggata    70620

ttagcctttt gtcagatgag taggttgcga aaattgtctc ccattttgta ggttgcatgt    70680

tcactctgat ggtagtttat tttgctgtgc agaagctctt tagtttaatt agatcccatt    70740

tgtcaatttt gtcttttgtt gccattgctt ttggtgtttt agacatgaag tccttgccca    70800

tgcctatgtc ctgaatggta atgcctgggt tttcttctag ggtttttatg gttttaggtc    70860

taatgtttaa gtctttaatc catcttgaat tgatttttgt ataaggtgta aggaagggat    70920

ccagtttcag ctttctacat atggctagcc agttttccca gcaccatttg ttaaataggg    70980

aatcctttcc ccattgcttg tttttctcag gtttgtcaaa gatcagatag ttgtagatat    71040

gtggcgttat ttctgagggc tctgttctgt tccattgatc tatatctctg ttttggtacc    71100

agtaccatgc tgtttgggtt actgtagcct tgtagtgtag tttgaagtca ggtagcgtga    71160

tgcctccagc tttgttcttt tggcttagga ttgacttggc gatgcgggct cttttttggt    71220

tccatatgaa ctttaaagta gttttttcca gttctgtgaa gaaagtcatt ggtagcttga    71280

tggggatggc attgaatctg taaattacct tgggcagtat ggccattttc acgatattga    71340

ttcttcctac acatgagcat ggaatgttct tccatttgtt tgtatcctct tttatttcct    71400

tgagcagtgg tttgtagttc tcctcgaaga ggtccttcac atcccttgta agttggattc    71460

ctaggtattt tattctcttt gaagcaattg tgaaatttag tataatgttt agtataacat    71520

agtatacatt gtttagtata attgtttagc ataacatttt tggacatgac acagtgatct    71580

gccaaatttt ataatcatac ctattttttc ctgctaataa ttaactctca tgtgtatgca    71640

gacccaaaaa tcacttaaaa gtttttaatg agaatgaaaa ttgctaattt caattttaaa    71700

ataccaacaa ttctttttat taaaatttca agtataaggt aacttgatct tgccaatact    71760

atgtagtatg ttgtgatttt tcatgttagc tcagatgacc tccggtttat aaagtctccc    71820

tgataatttt gacagtcatg tgaccctgtt ccctcttcac tctcattctt ccccctttat    71880

atttttctgt atgatatctg tcacatcttg ccttatatta gttactttct tcttttcatt    71940

tttctaggaa gttccttgaa tacaaaactc atgccttatt tttgttcaaa ctccttttca    72000

ttacctgtta tgatatagtt tctgactata catgtattag tctttttttt tttttttttt    72060

ttgagacaga gtctccctct gttgcccagg ctggagtgcc gtggcgcgat tttggctcac    72120

tgcaagctcc gcctcccggg ttcacgccat tctcccacct cagcctccag ggtagctggg    72180

actacaggta cccgccacca cacctggcta attttgtttt tgtattttta gtagagacgg    72240

ggattcaccg tgttagccag gatggtctcg atctcctgac gttgtgttct gcccaccttg    72300

gcctcccaaa gtgctgggaa cacaggcgtg agccaccacg cccggccgta ttagtccatt    72360

tttacactgc tataaagaac tacctgagac tgggtaattt ataaagaaaa gagatttaat    72420

ttactcactg ttctgaatgg caggggaggc ctcagaaaac ttacaatcat ggtcgaaggc    72480

aaaggggaag caaggcacat cttaacatgg tgcaggagag ggagaaagag gagggaaatg    72540

ccgcactttt aaacccatca gatctcatga gaactcactc actcactatc atgagaacag    72600

cactggggaa accgctccca tgatccaatc acttaccacc aggtccctcc cctgagacgt    72660

ggggattaca attcaaaatg agatttgggc ggggacacag agccaaacca tgtcaataca    72720

attgcagaaa gaatggatga ataatttttt aaaaatacag tctactgaga tttaagacaa    72780

aaaggattgt acttgaggac taggtattaa ttttaaaata attttccatg taaaagtgaa    72840

ttttacatta aattgtattt agatagaact gatacagtga aagggagcag gaaaataaaa    72900

ggacacctga aaacaataga ctctgatttg ttttcttgag ggaacgctgc cgcatacaaa    72960

taaaaagcct gactcacaga cttacctcct gaatacggtg agaaatgctt attgccagaa    73020

acccactgat aaccctatat aaaatttaga aagtcagtgt ctttcagcta acacaagtca    73080

tcttcctgcc aaccggagaa aaataaggct gggatttgaa ctttgtcttt ctgatttcta    73140

agccaatgct ttaggttgct ttaatatttt gttgttactg ctggttgttt ttatttctta    73200

actgaatact aaagctatgg aaaaggacac ttatggaatg gctacaataa catttcaaga    73260

atgtttgctt ctattcatat cgttttttaa attaccgtgg ttagtaagtg aggaatcctc    73320

ttaatttaag tcccttttaa aagctaatat tagtattata actaaaataa agaaattgaa    73380

ctcagtgatt ggaaggattc ttccaactct gacgttcctt caacttagga aaatattttt    73440

tgaaataact catattttgg aacatgtgct gctaaccata acaattgcca gcaagtatta    73500

aaattctcaa ggttttatga taaaaatatt agagatagct agtttctatt tggctttctt    73560

aaaatgcagt gtaatggaag ggaaagaagt tgtactttaa aataacttaa ccacagttat    73620

tgttactggt gaaagaaaat gaaaaatatg aaatacagta ttttgaaagc tctaagcaat    73680

acatgctaac aaatagctca atttttaaag ttactatgaa gaagtggact tggagttcat    73740

tggccaaggt gacattgata gatgcgttga tgacattgga accacattgc tggagtctga    73800

tggcagtgtt tcttcaatat aacactgcca tgtagaaagg taaactgctg atattgatgt    73860

gaaaaattga tattttggat tctcaatttc atcctttctt tttcctcctg cagactttca    73920

tagtattgaa caaagggaaa acaatcttcc gtttcaatgc cacacctgct ttatatatgc    73980

tttctccttt cagtcctcta agaagaatat ctattaagat tttagtacac tcatatcctt    74040

ttaaaaatga ttacatccag tggcacttta tggtgtaatt tttgctattt tattcaaata    74100

tagatgttat accttttgca ccttgaaaga ctctggtttt agtttattaa tttcagtatt    74160

attaatataa tttgtcatgg gtctcagaga agactgggag agtggcaata ttaagatttt    74220

aggatatgtt acttttattt attactctct tgttcaaaga gacaaaatag tctacaagct    74280

catttagaat ttttttctta ggaaaagttg taagcatttc aacaagtgtc atcctcaaat    74340

atttcaaatt cccactgtcg tctcttttgt tccttgattc taagctacct tattcagcat    74400

gctcatcatg tgcactattc tgacaaactg catatttatg accatgaata acccaccgga    74460

ctggaccaaa aatgtcgagt aagtgggtat aagtacattt taatatagtt ttggtattat    74520

catttcatcc tttccttttc ctgccaggaa gttactgcat ttatgaagat ggggaatctt    74580

taccttccca tgttatatgc ttgcttttct tttgttcttt acctcctcta tgatattaac    74640

ctgctagatt agaaaaatta gatgctacag tgttttctca aagaatgaac ttgtcagatg    74700

ctccatcctg ttcttagaca tgttacacat attttattct tgggtgtatg ttttataatt    74760

atatgggtgt atttttaaat gattgggtga atttttgata gaagcaatgt aggaaatttt    74820

taggcagatc tgagacctat attcttagtt atttcaagta cctctgcttt ctgggagtgt    74880

ttctgatatt gacattttaa tattttctgg atagacctat tgtagtttaa tagggtgtgt    74940

ccataaccca acagccatcc tccaatatat gtcttccagt ggttaattag agaaaataag    75000

ttataaagat ttacatggtg gttgtattct tttcacatct agtatcccaa tggaatcttg    75060

tgtttaggta cacttttact ggaatatata cttttgaatc acttgtaaaa atccttgcaa    75120

gaggcttctg tgtaggagaa ttcacttttc ttcgtgaccc gtggaactgg ctggattttg    75180

tcgtcattgt ttttgcgtaa gtactttcag ctttttgaaa cggcaaattt atgaaaatct    75240

caggcagcac agtgttccaa taacagcaaa cctctggggt ctgatttttc cagcatggaa    75300

tgtctgtatt taaaggaaaa tggaagctat atgaaagcta gtcattgata ggcaaatact    75360

aaatttttca aaaagactat ctcccactca gaggtatgtg acatcattga gattgatcat    75420

cttcctccat gctcagcact tggatggata gtctatgcag tgccaattag gtttacactt    75480

tttccaagtt cttgtttaaa aatgaataaa acctataaga agcacacaaa aaactcaggc    75540

ctttaaatac aagtacagtg ctctttatat taccctgtat tattcaatta ttttatattt    75600

ttgtattaaa atataaaagt atatatttgt aaaagagctg tcactgctta ctaagcctaa    75660

gattaatgca ttgtatacac attatatata cactcagttt attttcaagg aaaatattac    75720

attacagtat aattttaatt tattcataat tgttactctt ttcccaaatg tatttatcag    75780

aaaaatggat ttttacaatc tcatatctag atattctatt ttccgttaat gactttgaat    75840

tatcaaagta atccaggttc actggagcca cctagacaat acagaagggt cttaagattc    75900

ctaatatccg attccttcat ccctgcctaa cctcttttcc atcaggctcc ctccttttga    75960

ggtcacatat gatggggcag ttccatctgc tacctgctgc taagaaaaca ttgtgcaaag    76020

aagactgcct cttctcatag gtctcctttt tttcctattg gtacaattca aatactacaa    76080

aattcacaat tttaaagtat acaattcagt gtttttcagt atattgacaa acttgcgcaa    76140

catcaccact acctaattag agaagtttaa caaccccaaa tagaaactct gtactcatta    76200

gcagtcactt caatttcctt ctctccctgg ccccttggaa accactcatc tatgttttat    76260

ctctatggat ttgtctattt ggattttttt atgaatggaa atatcaaaca gtatgcagcc    76320

ttttgtgtct gacacttagc atactatttt caatgtttta taaaaaatta aaagtctaaa    76380

ttaccataat gttaagggtc caacaattga aacatttagt tgtttacgca tttaagtgta    76440

tgaatccaat ttaataatat ataatatctg tattttgttt gcatcaaatg agtcaaatca    76500

atgctaatta aattaagtta gttatgatag caaaaaagac ttgcagaact atacatttaa    76560

aatagaagcc ccaaacgtag aaaatacctt gactaaaggc tcaggtaagt atcatagact    76620

ctatctaaat tctgaataat tctgatttaa ttctacaggt atttaacaga atttgtaaac    76680

ctaggcaatg tttcagctct tcgaactttc agagtattga gagctttgaa aactatttct    76740

gtaatcccag gtaagaagta attggtgtga agcattaggc cactcataac tccaactatt    76800

tgggagttgt tctttgttcg tttgtgtgtg tgtcgtcact gtgtgtataa actcccctat    76860

tacagatatg tgacagagtt tgtggacctg ggcaatgtct cagcattgag aacattcaga    76920

gttctccgag cattgaaaac aatttcagtc attccaggtg agagtggggt taaacaccag    76980

ggctgacttt gatcttttga aagaaagaca taaaaaaaac ctttctttat gcaattttaa    77040

ttaaatttga tttcttctgt tttccacaat cattatcaaa agtcaacctt tgagtttaat    77100

caattgcatg ggtctttagg atgaggatga ctacttggct cacatctcaa cttgaaatct    77160

tccctcctgt ctgagggttt gtttttccat ttgcttatac aggaaggaaa atttcaatcc    77220

attttaattg attttaaaat acttaggaaa gagatcataa atatcagcat ggggatattg    77280

catgacattg ttttttattt tttctcagca aaccatttct ttattgaaaa ttattacaag    77340

gtgtcactat atgctgtaat ttgttttggt gccatttata gagaagtggt ttgtttgaca    77400

aacattagaa cttacaaaaa ttatttttaa agtggtttga atagccaaat tgttcatttt    77460

gacaacctag gtattctttg agaatatgtt cctattttta accatttgct gtaatatata    77520

aaaacaaagt atatataaaa tagcaaaccc agaaggcttt ttttgaatta ggttacttaa    77580

ggtcattgat ttgatataat gcatgacttt ctaggaaagc ttgtgttttt tgtttcgatt    77640

cagaggcttt atgtcattac aaacactttt ttctcccatt ttcaggcctg aagacaattg    77700

taggggcttt gatccagtca gtgaagaagc tttctgatgt catgatcctg actgtgttct    77760

gtctgagtgt gtttgcacta attggactac agctgttcat gggaaacctg aagcataaat    77820

gttttcgaaa ttcacttgaa aataatgaaa cattagaaag cataatgaat accctagaga    77880

gtgaagaaga ctttagaagt aagaatgtcc ttgcatttgt tattaggttg aaataatgct    77940

aaaaacattg ctctctttta ataatgaaat gttgctttca ttttaatcat ttcaaagcta    78000

ttcaaatata tagaaagctg ctacagtgtg aatttgggtc atgttatata tgattttcat    78060

aaatcatcct ggttctaagc tatctagcag tactggcaaa aggaacacag gatagttcca    78120

taattcctaa tttctatatc ataaaaaaga attattttct ctagagaaat aaatgtagcc    78180

ttgaattaat aacattaacc attacattta acaatataat agattatata ttttatataa    78240

ttttattata tagtacatac ttatatttat tatatataat gtgacatatt tattatgata    78300

gatttttata cttaatagat tgtactcata actataacat cttaaagttc tattaatcat    78360

atataatgat aatattaatt atcaaatata aagatagtat ctgtatcttg atagtattcc    78420

taaagatttg tacaaagcaa aatcatttgc tcagctttat caacatccac tttgtaacca    78480

atgacgagtt tcatagctgt ttttaatggc ttccttcaat ataggctgat ggcaagatat    78540

caaagtttag ttcagtagaa ttatttctgt aggtaccaca tgagatcatc tgtatgcact    78600

ctcagaagtc tgcttaattc agaagtatca attagagttt cttacataaa gcatgaattg    78660

aatgttctct aaacaattat cccctagcat ggtgtctctc actggaacgg ttgatgaata    78720

ttggatgaag atatgatcaa gattgtactt tctgtctgac acctggaatg tatctatctg    78780

atggtgccca cgtgaataca taaatcttaa tagataattt gacccaggtg tggtatggaa    78840

gtcacgaaac ctttcaaata tatgtgctgt tgccaaaagg aaatgaggga ggaaaggtca    78900

ggattctcct tagataataa aaagtaatat acatcatttt cttattttac caaatgtgtc    78960

ctttctcact cactgtgata aataaaatca aataacacct agcccacatg gtaaaagact    79020

ataaataaaa tgacagaaaa aaatagaagc cttaacaaga aaactgaaag ttttgaagta    79080

aaatgtttag catatatatt tttactacca ccatttgatg aggaatttag catattttcc    79140

ccttcttttt atatttaccc tcttttccag tttctgattg ttacaaacat gatttgaaac    79200

ttatttccaa tggatggaga attttatttc ttaatttata tgctgtaaaa ttaatatatc    79260

tgatgagtaa cttacattta atattgtaga ttattttacc acacttattt aaacttaagt    79320

tttctcactg ggatctgtcc ttttattctg agtcttgctc ctatttctga gtttatactg    79380

tgaatggttt tcttaacctt tgttaaaaga aaaattttca acaaattaaa tttagcagct    79440

tatttcagca atgaaatagt atttattgct gaaataagat aataataata atgatttagg    79500

cagcactcag aaccaagaga agttcggaga gctcaactca gcaacatgag caggagtatt    79560

tatagacaga aaaagggagt gacgcacaaa aacagcttga ttgcttatag cttgacattt    79620

gccttatgtg gacattgtct gataaatcag caggctgtgg ttggctgaag ctcagctgct    79680

gtgattggct gagacagcta cttgttacaa gaatatacta atagattaga atgcaatttg    79740

tttacatatg aagttagatt gcaattctct atgtacacag acagccttta atcaaattta    79800

atttaattca tcgctttctg gaattgcttc atgtattttt tttttttttt gctaaaaaat    79860

aatacaaaaa aagaagaaaa aaaaagaaac cccgtctcta ctaaaaatac aaaaaattag    79920

ccgggcatgg tggtgggcgc ctgtaattcc agctactcag gaggctgagg caggagaatc    79980

gcttgaactc gggaggcaga ggttgcggtg agccgagatc gtgccattgc actccagcct    80040

gggcaacaag agcgaaactg tctcaaaaat aaataaatta ataaattaat aataataata    80100

gagcccttga gttatgtgaa ttatctttat attatattta aacatgaatg catgacaatt    80160

agctaataat gaatcttata ccacaatcct gtcttccaaa tctgtacatt attctttatt    80220

ttcttctgaa atgtagtttt agtgaagagg tgtttaaatc aagtctgaat tttgcttctg    80280

tttcctatgt catagaagcc atttttgact gcataattga ttcaaacttt catttattgg    80340

tgcgtttatt acatggtttc cctgagctat agcaataaat gatagcctca gcccttgctt    80400

tcacagagct tatcatctag tgggaatgaa aaaaaatgtt taagggggaa cagacaaata    80460

aattaaaaat atctcaagtt ataataaatg ccatgcaaag gaagtgagtc tcaggtgctg    80520

agatatcaac tagatgagaa gacatctctg aggtgatggc atttaagctg agatctaaaa    80580

gatagtaaga agccataaaa tagtttaagt gtgggtgtga gtctatgtgt ggggggtgct    80640

gcttcaatta ggagaaatag catgggcaaa ggtcctgaat aaagggaggg tatgggttta    80700

aagaatggaa aaacagcagc gtggtttggt aagagaaagg aagaatggca acagagaaag    80760

tagcagaaaa aataggggtc atatcatgca ggacatttca gcccatggga aggagtttgt    80820

attttatttt aaatgcagtc atttttattg ctgtctgtct tgtgcacaac tgattgagca    80880

agggtagatg gtagatggga ataagaaagg taagttgaag gttgcttctc tcatctaggc    80940

aagagaaaat aaaggtttca tctagagtga tggcagagaa atgaagagaa aaaagatgag    81000

ctcaacatac aaagtctgta gagcttgctg atggattaaa gaagacagga agcattgagg    81060

atgacttctc agtttctggc tgcaataact ggatgggtgg tgatggttaa tgaggaaatg    81120

gtggacacat ttgtagagga aggtcactat tagctagcta aaattaaaat gagatgcctt    81180

tgagatgtcc aggtggatat ataatataga gaattggaga tttaagtata gaaatcagag    81240

ggcctgctga gtttggagat aaattccaga gcaatcagca aaaagaaagg acacacacac    81300

ctctacctct gaacatccct gatattttta agtagataga gaatgggaaa cctggtattt    81360

aaagcaatct ggtaccaaga tctacaactc tgacatttag aattcaggta gaaaagagga    81420

cccagaaaag aacacagaga aagagccgcc aataaagtaa gaagcaaaga tataaataat    81480

gaagccaaga gaagaaaaca tattgtagaa acagatgtgc ttgtgtagaa tcatgctgca    81540

agatcaagga gtaaggatga tgaagaaaga aatatgcatt aggttaagta acagggaagt    81600

catcagagaa tttcttgaga aaatttgggt aagtggtagg gttcaaggta agaataaggt    81660

gcatacaggg gtgaaaagaa gaggtcagaa agaaggtaat atgtgtagac aattctccca    81720

agaaatttgg ctataaaggg aagcagaata atggggcaaa tggctggcat ttaaaaaaat    81780

atatgggttt ttgtatggat gttttgctag tgataatgaa tgagtagtta tatatgaatc    81840

aattcaggag agagagggag aagtcaagtc ctcgtgaaag tgaaagagta aaggggagcg    81900

acagctccac cgaaacagga ggaaagatag aagagaagac tgcagagtta tcaaaagatg    81960

attgagttca aacccaatgg tttttatttc ctcaaagtat aagatgggat cattgcctga    82020

gagtgcaaat gaggaagaga aaattctaca gatgatttga tgagaatgca ttatatatat    82080

ggtcatatca gggcatgaga aatttagtgt attttgagtg caaatttgat gttggagatt    82140

acttacttaa aatataacca ttcacttggt tgtgagagtt tctccaccaa cattcagcca    82200

tttggtagcc agcatggaaa agacagatgc cagattatgt gtagactgtg gttctgccag    82260

gttaggcact gatgataatg aatgcccatg gatttaagct gtacaaagag tgacaagaac    82320

ttggttgata gatcatgaga aagtgctaag gcaaatgaat tggcaatatt taaaagatca    82380

aggaattata atggtaaagg caatctacac agagaacctg agcataatct aaaagcattt    82440

tctggtgcct atagcaaagt attttccgaa atgcctttcc aaattcacaa tcaaataaat    82500

taacccactg tctcacctcc tgctgaaaaa catacaattt gtagatttcc tttggtgttg    82560

ctgtctactt tgatgctcat caaacacttt tttatgctgc tacagatgaa agtggggttc    82620

atgtgcacag tgtgtagcta aatgtgcagt attatggaga aatatactgt ggttatattg    82680

ggctaaaaca ggatattctc ttcctcctgt ttttctaata tttgacattt aatagagaaa    82740

gttttgaaaa aaccgcaata ttggccttca ctactaacag gaattttcct atctccttca    82800

tctacagctg ttttcttgtg agaactacat ttgccagagt gtagagtatc atgtgcaggc    82860

cctctgccca gtcctgatcc cctgcactag ttttctcaga gttgcattat ttgcccttcg    82920

ttggggatat actcttcact tccataggcc caagccatac acaattgtca taagttgtct    82980

ttctgagcaa gggcagaatt accatttttt tttctatttt gctacattaa tcttgaaaat    83040

taatttaaaa acttcaccca gaatcttcat tagatttaat atcaattctg tatttttgtt    83100

atatcaattt tcattttccc catacgtatt ttagtgataa gttggcattt atttaccccc    83160

acccacaacc tttgccgtta tgctgcattc ccttttaaaa ataggtttat tgaggaataa    83220

tttatatgcc acaaaattcc tttttttaaa ctgtataact cattttttaa actatactca    83280

gagttgtgca acgatcgcca ctatctaatt taaaatattt tcatctttcc caccaagaaa    83340

cccagggccc gttagtagtc attccccatt tcccttttct cccagcccct ggcaaccact    83400

aatctacttt ctgtccctag ggatttaccc actctgtaga tttaatatac atggaagcat    83460

ataatatatg gctttttgta tctggcttct tacacctagc ataatgtttt caaaatttat    83520

ccatggtata gtatgtatct atgcttcatt tctttttatt gctaaatgat atttcattgt    83580

atgtatatgc tatattttgt ttatacattc atcagttgat ggacatttgg gttatttccg    83640

tcttttggtt ataatgcata atgttgctgt aaacattcat gtacaagttt ttgtggaaat    83700

acattttcaa ttttcagttc tcagtatata cctagtagtg ggattactga gtcatggttc    83760

tttttttttt tttttttttt tttttttttt tgagatggag tctcactctg tcgcctaggc    83820

tggaatgcag tgtcgctatc tcggctcact gtaagctccg cctcccgggt tcacaccatt    83880

ctcctgcctc agcctgccaa gtagctggga ctacaggtgc ccgccaccac gcccagctat    83940

ttttttgtat ttttagtaga gacggggttt cattgtgtta gccaggatgg tctcgatctc    84000

ctgacctcgt gatctgcccg cctcgacctc ccaaagtgct ggcattacag gcgtgagcca    84060

ctgcgcccgg ccgtgattca ttctttatct ttcagaatca tcccactttt gaatatgcac    84120

aagcaatatt tcatttttct ttgcattcaa ttttttccca tttttaaaga tgttaacctt    84180

aaatcttctt gaagccaacc atcttaataa tttaatgtct agttgtttag aaattattgt    84240

aaagttttct acaaacctag agtgagctac ctgcattgct ttacctttca tcattcttat    84300

actgtgttaa atacagtagt atagcagtgt gctaatagac agctccagag cccattcata    84360

taattcagct cctcagtggt tgataaatgt gaaccagcat tagtttaaag gataattcta    84420

aagtaatcca tccttattaa aatattttgg atgtttatgt atgcaaaatt gcatcttatc    84480

ctctcccata ctcactctac caggcccatc cttcccgagg ttcaggagtg ttttcaggaa    84540

agcttttcat gcacattttc acctacattt gcacctcaaa ctgcaaggct ttattgtttt    84600

atctgtgtct tctaagtaag ataaaatgat gatgtgtaat tcaatcaata gttttatctc    84660

aaattgtata atagtttaac taattataat aactcctgtt tttgagcagc tagtacagaa    84720

tgtgtggatc acagtatcaa gtggtttaca tgcaatatcc tatttatact atttaacaac    84780

tttataaagt aggtattctt atacgtattt tacagatgca gcagctaagg cttaatggct    84840

taaagataat tcacttactt aagaagggat agaagcaaca ttcaaatcca agaatatctg    84900

atttcatagt ctttcttcca tgattactcc aaaagtctcc caataatcag attttttaat    84960

ttgacctgag taaaatagga agtcaggttc ttatagtaga atagatattt aagagagatg    85020

acaaaaggtt ttttagtcat ttaaacattt actatacaag gatagatctg cccccagtct    85080

taggaacaag ccttaacagc aaatgacaga agagttgatg agaactttta ctactaaaaa    85140

ttagcacaaa gaataccatg aaaggtgaaa catggaaaat ctgcattgat tacattgtca    85200

tctcctcaac acctagaatt agtaggtcct aagtaagtat ggactggtga atgaaaagta    85260

agataatttt agaaaacaaa ttttactcac ttatgttact gccttactga gtctgcctct    85320

tccggagtat tgtaccacat aaggatgttt tagtcaatag cggaccatat atataatggt    85380

gatctcataa gattataata ctgtattttt ttactgtacc ttttctgtct ttagatacac    85440

actttccatt gtataacagt tgcctacaat attgagtaca gtagcccact ctacaggttt    85500

gcagcccagg agcaataggc tataccacat agcctaggtg tatggtagcc tataccatct    85560

aggtttgtat aagtgcaccc taggatgttt gcacaaggac gaaacgtcct aatgatgcat    85620

ttctcagaat gtatcacagt cattaagtga cacatgaccg tacctttaat catacttaaa    85680

atccaaactc atttctatga tatgcaaatt ccgacatgat ccggcccctg cctacctctg    85740

ccatcacaat cctccctctc accacactgt agccacactg gccatcttgc tggcttttcc    85800

acacaccaac ttcatctctg ccttagggct ttagttcttt ctcttccccc agcccaaata    85860

tctcttcacc agtattttca tggctgtctt ctttgtcaca cttaggtctt agtttaaata    85920

tcatctcctt agaaagaccg tccctgactg cagcctacca cgttgcctta atttattttc    85980

tttagatcat ttatcactat ctgaaaatat cttgtatatt tatttattta cttaaatttt    86040

tatccaacca caacctccac cctcacctaa acataaagga ggtctcataa aactaatgat    86100

tttatttatc gtgtttattg tcatgtttat tgcctagcct ctaagagatt atcaataaat    86160

atttgaggga gaatatatga gaaaatagta aataaatgga tgcatattgc ctgggaccag    86220

gcctgaattt gtagataaat gtctatatca attaatttac ctcctttatc acaatcacag    86280

attaaagtct gtgatgttat aactgttcaa attcttcttc aacagaatat ttttattact    86340

tggaaggatc caaagatgct ctcctttgtg gtttcagcac agattcaggg tatgtaatat    86400

ttgttttctt tttagtctaa aggctgaaag agaaggaaaa gaatgttcag tcagtttgca    86460

aattagtctt tgattctata ttgcttttta tatatttcat ggtattattt gactcattct    86520

gtcccacagc aaatccagtc tttaaaatgt tcacagttaa tgcatactct tgaaagcaag    86580

actttgagac agtgctcgaa ttaacacaag acagaagtca tataaatctt aagaaggtag    86640

aaaatgttac ttctagaaaa ctccaccaaa agttggttgg ataatttcag gtcttctttc    86700

tggaaaacga agagtcacaa agtctatttt tctttctact cccaagttcc actcattctc    86760

caattaaatg tgactcatag gtgactgaat gtcatgtttt ggccactcta agcaaaggga    86820

ttccttggac ttgggtacac atattttaag aatattgtat atataagaat attgtatata    86880

ttcaactgtc catcttgctg cttctctctt acaccaactt cattttgtag catcagctgc    86940

ataagctctt gcttttcccc ctatgcagac atctattcat caggctctgt gtacactggc    87000

aacataggaa taaactggat aaggttgctg ttcccagaag aatctcagaa tattgtattt    87060

atttaatggc atcaggaaaa accagtccac caattttaga aagaaaaaag tcttaaagct    87120

gcacattttt atgaacttag acaattacta tattttgact attattgact ctaatctatt    87180

ccaagaatta tacagacaga aagagctttg gtaacagcct acatatcaat atttactgaa    87240

ccaagaacta tcacaaaacg tctgttgaaa atttccatgt tttaatgatg atgatgctaa    87300

tggcagctat gatttattaa acactttcta tgtgcaggat gtaagctaag taatttgtac    87360

acattatctt atttaaactt attacaagtc ttattttctt gaggtagatg ttattatcct    87420

attttcacag acagacttat gccttgaaga atttggtaaa gtcactaagt agtcagtagc    87480

caaatcatgt attcttaatc cttattcaat attgtccccc tatagaagaa accttgagtt    87540

tgtaactttt cagtaaggct atttagcttg tgtcctgaag acactctcac ctataatgtt    87600

ctttctcgtg tgtagtcagt gtccagaggg gtacacctgt gtgaaaattg gcagaaaccc    87660

tgattatggc tacacgagct ttgacacttt cagctgggcc ttcttagcct tgtttaggct    87720

aatgacccaa gattactggg aaaaccttta ccaacaggtg agtaccaaga gaaacatgca    87780

ttgtattttt gaatggcata tgtacctggt gtatgttaag agcctgtatt aggaggtttt    87840

ttatttattt gagaatggag gaaactctat tatcttatta ccaaaattat aagtgtttta    87900

ctcccatcac taataatatg ggtagttctc gaatcataaa taattttctt atcttttctg    87960

ggcatattta atctctagat ctctcgcctt cctgagtata tcatcccatg gggtcctagt    88020

taagtaccag gacatactgt aatgttttct caagctgctc ctgcacatgg actgttttcc    88080

atgcgtgctt gggatggcct gaagagaaga ggctctctga tgttcacctg ctcaccatgt    88140

tttatttttg aactcctatt taaagttaaa gatgcaattc atttctctaa gtttttctct    88200

cccaaatcaa ttgctcccaa ctgtagactt ccatgatttt ttgtattttc ttccatttat    88260

atcattgatc tcttgtattg caagtggtaa ttcatgtggc tatttcctct aacttgaatg    88320

tgaacctctt ggggctgtgg tctccattta cttgtatagt ctcagcagcc aagccaaaag    88380

gaaggagacc aaaatgatta ttctatagta cacataacaa tgattcactt ttctcagaat    88440

agctgcagat ctgttttttt ttcttttttg gcctatttta tatttacttt atttccgaga    88500

atattataaa tgaattcgga aattatgtaa gatgcacttt acagcaaaaa tgggaatgca    88560

aatatttttt aaatatgcaa gaagtggtca cctttactca aaattaaaga aacacaaata    88620

aaaaaattaa aataattttt catcagaggt aagacttatt tttcatttaa tatcagttga    88680

tactatccta aattcacttt aaaatgcttt gtatgataaa agtatattac attatacaat    88740

tattaataga aatgttaatt atcttataaa tttgtttaag ttacttgtag attcttaata    88800

ttagaccttt gtcagatggg tagattgcca aatttttctc ccattctata gtttgcctgt    88860

tcactctgat gttagtttct tttgctgtgc agaagctctt tagtttagtt atatcccatt    88920

tgtcaatttt ggctttggtt gcaattgctt ttggtatttt tgtcatgaag tctttgccca    88980

tgcctatttc ctgaatggtg ttgcctaggt tttcttctag ggttttcatg gtttggggtt    89040

ttacattaag tctttaatcc atcttgagtt aatttttgta taaggtgtaa ggaaggagcc    89100

cagtttcagt tttctgcata tggctagcca gcttccccag caccatttat tatataggga    89160

atcctttcca cattgcttgt ttttgtcagg tttgtcgaag atcagatgct tgtagaagtg    89220

tggtgttatt tctgaggtct ctattctatt ccattggcct atatgtctgt ttgggtacca    89280

ctaccatgct gttttggtta ctgtaacctc atagtatagt ttgaagtcag gtaggctgat    89340

gcctccagct ttgttctttt tgcttagaat tgtctttgct atatgtgctc tttcctggtt    89400

tcatatgaaa tttaaagtag ttttctaatt ctgtgaagat gtcaatggta atttgatggg    89460

actagcattg aatctataaa ttactttcgg cagtatggcc atttacatga cattgattct    89520

tcctatccat gagtatggaa tgtttttcca tttgtttgtg tcctctcttg tttccttgag    89580

tagtggcttg tagttcttga agaggtcttt catatccttt gtaagctgta ttcctaggta    89640

ttttattctc tttatagcaa ttgcaaatgg gagtttattc atgatttggc tctctgcttg    89700

tctattgttg gtgtatagga atgcctgtga tttttgcaca ttgattttgt atcctgatac    89760

cttgctgaag ttgcttatca gtttaaagag ttttggggct gagatgatcg ggttttctaa    89820

atatagaatc atgtcatttg cagagacaat ttgacttccg gtcttcctat ttgaataccc    89880

tttatttctt tctcttgtct gattgccctg gccagaaatt ccaacactat attgaatagc    89940

agtggtgaga gagggcatcc ttgtcttgtg ccagttttta aagggaatgc ttccagcttt    90000

ttcccattca gtatgatatt ggctatggag ttttcataaa tagctcttat tattttgaga    90060

tatgttccat caatacctag tttattgata gtttttaaca tgaatggatg ttgcatttta    90120

ttgaagacct tctctgcatc tattgagata atcatgtggt ttttgtcatt ggttctgttt    90180

atgtgatgga ttacatttat tgatttgcat atattgaacc agccttgcat cccatcaaaa    90240

agtgggcaaa ggatatgaac agagacttct caaaagaaga catttatgcg gccaaaaaac    90300

atgaaaaaaa gctcaacatc agtgatcatt aagaaacgca aatcaaaacc acaatgagat    90360

accatctcaa gtcagtcaga atggtgatta ttaaaaagtt gagaaacaat agattctggt    90420

gaggctatga agaaatagta gcacttttac actgttggtg ggagtgtaaa ttagttcaac    90480

aattttgaag acagtgaggc aattccttaa ggacctagaa ccagaaatac catttgacct    90540

agcaatccca ttactgggta tataccgaaa cgaatataaa tcattctact acaaagacac    90600

atgcacacat atgtttattg cagtactatt tacaatagca aagagatgga atcaactcaa    90660

atgcccatca atgttaaatt gtataaagaa aatgtggtac atatacacca tggaatacta    90720

tgcagccatt aaaaaagaat gagatcatgt cctttacagg gacatggatg aagctggaag    90780

ccatcatcct cagcaaacta atacaggaag agaaaaccaa acactgcatg ttctcactca    90840

taagtgggag ttgaacaatt tgaacacatg gacacaggga ggggaacaac acacaccggg    90900

gcctgttggg gggtgggagg caaggggagg gagaacgtta ggacaactac ctaatgcatg    90960

caggtcttaa aacctagata atgggttgat aggtggagca aaccaccata gcacatgtat    91020

acctgtgtaa ccaacctgca tgttcttcac atgtatccca taacttaaac atatgaaaaa    91080

aagctcatca tcactggcca ttagagaaat gcaattcaaa accacaatga gataccatct    91140

catgccagtt agaatggtga taattaaaaa gtcagaaaat aacagatgct ggagaaaatg    91200

tggagaaata ggaatgcttt taaactgttg gtaggagtgt aaattagttc aaccagtgtg    91260

gaagacagtg acccagcaat cccattactg ggtatatacc caaaagatta catatcattc    91320

tatggtaaag acacatgcac acatatgttt attgtggcac tattcacaat agcaaagact    91380

gggaaccaac ccaaatgccc atcaatgata gactggataa agaaaatgtg gcacatatac    91440

accatggaat actatgcagc cataaaaaag aataagttca tgtcctttgc agggacatgg    91500

atgaagctag aaaccatcat tctcagcaaa ctaaaacagg aacagaaaac caaacaacgc    91560

atgttctcac tcatgagtga gaggtgggca atgagaacac atgggcaatg agaagatcat    91620

cacacactgg ggcctgtcgg tggtgggggg caaagggagg aatagcatta ggagacatac    91680

ctaatgtagg taacaggttg atgggtgcag caaaccacca tggcacgtgt ctacccatgt    91740

aacaaacctg cacgttatgc caaaaaaaag aaaaaaagaa aaaaaaatct ctgtaccttc    91800

agtttaattt tcctctaatc ctaaaactat tttgaaaaaa aattctattt taaaaagcaa    91860

agaaagcgaa aaaaaaagtt aattgaaaat acctatgaga tgaataaagt aattaaataa    91920

gaccatctgc ctagtgttaa cattcaatga tattattaat atttgatgat aaagaaagaa    91980

aagatagaat tttaacagta aaagggacta tggatatcac ctgttcctaa aatttgaaag    92040

tgagcaaagg atttaatttt atgagtaatt ttcagactgt aggaaaaaat gcatgatttt    92100

tatactacta cacttaataa tcaagaatct tacatgactt tagtacaagc atattacatt    92160

gctatattct tcgtactgaa aatgtgttta atatttgttt tccatgaaga tataactttt    92220

ctctttatat ttttgataac atgagattat accaaactgt cagatttgct catgcctgtc    92280

aaattgaaat aatttactaa aaaaactttt tattgttcaa atgacaattt ccatttttcc    92340

ctagacgctg cgtgctgctg gcaaaaccta catgatcttc tttgtcgtag tgattttcct    92400

gggctccttt tatctaataa acttgatcct ggctgtggtt gccatggcat atgaagaaca    92460

gaaccaggca aacattgaag aagctaaaca gaaagaatta gaatttcaac agatgttaga    92520

ccgtcttaaa aaagagcaag aagaagctga ggtactgtta tttgatttaa aattcttcct    92580

agaggtagaa atgcaaacgg ttacaacaga ggctctgcgg tatatgcttg gccttctcca    92640

gctagatttt ctttaatgaa tttttgtgta taaactgtat cctcatttct ggtgtggaaa    92700

aaggaaccaa ttctgggctg agctagaatt gatactttcc ccataatcat ctcactgcat    92760

gaaaagtgat ctaaggctgt tcctcttaaa ccttttacct acaatgactt agtgtgtgtg    92820

tgtgtatgtc tatatataca tacacatata catataaatg tgtgtgtata tatatatata    92880

tatatatata tataaacaca tggaactatg tgttttttta aattattata tcatgaggaa    92940

aaatctttta gaataattga ttaaataata tagtcagata tataatatat atataatctc    93000

aatttatata tatatacaat atatatatgt atatatatac acacatacac acaatggatt    93060

tccccagagt accaattgta tacagtggtt tcatgaaaat tattttaacg ttaaaattaa    93120

cagatactct tctatggggt atgactaaaa cagtgcatca tgttttgtta atgtcacaag    93180

gatttttaag ataaaacatg agatattaag aaaataattt tggtgtggct aatttaggtt    93240

gtcatagatt ctcgaaagtt tcctccttaa tcctctttcc agagagattc ttcagtgtaa    93300

atgtttgaga aggcttgtac taagagaaac ataatttcaa atgtactgca gttgccttaa    93360

catttgtctg aaggtttcac ctagttaaat ctcttcaagg agtctaatgt attaggggag    93420

ggcaatcatc tgcaatgcag ataaattctg atgcacaaat attcagtgca gcattttaat    93480

aatggtaaaa atcagaaaaa atttaaattt tggaaaatta gaaaataact aagaaaatta    93540

tgaaaattgt atatcttaaa gtattatttt gccatagaac tatgtgtttt tttaaaatta    93600

ttttatcatg aggaaaaatc ttttagaata atgatggatt aaataatata gtccgataca    93660

atctcaattt taaaattata catacatata aaaagaatgg aagaaatatt agcaccaatt    93720

atttctggga ggtaagatga ctttttttct gtttttcatt tatatcttta tttcccatgt    93780

ttttacaaga attttttagt gtttataaac aaaacatttt gtaaagggat agtactaggt    93840

tatcccaggt actacctagg gaattcccag aagtttcatt taggccaata gtcattgacc    93900

ttaccacttt cttacaatat tatgctttaa taattcattt atttttcaaa taactcaatc    93960

tttattaaac catagagtgc ctgattctat tgatgatatg gagttaattg cctgataatc    94020

aaattgtctg tcttattgca tggtttatgc gagttttaca ttccaaaatt accttgtaaa    94080

actttaacat ataatattta atttgtcttt actgtaagca aattaataac atgtaatagt    94140

ttaattctaa aatacaatag agctttattt caacctgaga caaaaaccaa atatatactt    94200

tgtaagcatt ctgatcattg tgtaaagaaa acgatcattt catgtttaaa ggacatgatt    94260

atatgcacca tgttgttatg ctaataggtg aaagatgtcc tgtcctaggg tttcctagga    94320

tttggaaatg actcatttaa gtgttaacgt cttggcccaa ccaggcaatt gcagcggcag    94380

cggctgaata tacaagtatt aggagaagca gaattatggg cctctcagag agttcttctg    94440

aaacatccaa actgagctct aaaagtgcta aagaaagaag aaacagaaga aagaaaaaga    94500

atcaaaagaa gctctccagt ggagaggaaa agggagatgc tgagaaattg tcgaaatcag    94560

aatcagagga cagcatcaga agaaaaagtt tccaccttgg tgtcgaaggg cataggcgag    94620

cacatgaaaa gaggttgtct acccccaatc aggtaccacc caaattgcta aatgtgtatc    94680

acccgaggca gaatgctaga gaaaaatgtc ttattttagg gtaagagaac tcgggagagg    94740

atagtgagtg atttcattgg tatgatttta ggtaaaaacc tagtatcgct aggcatttat    94800

ggaaagatgt acacaggttt ccatttgggt tcaatcattt ttgaaagacc ttatagtttc    94860

agaattgtca atatattctc taataaacta attttcagaa gcaaaatgtt cctgagaacc    94920

attgtagaaa taaagagacc attcacacta tagaataact tttatatttg tatttagtct    94980

gtgttttgta atgcttcatt ggttaaaaac taatcttaga ctagtttctc ttctttctta    95040

aacagtatag gtaatagtat cactcaccca tttggaactt tggagaagcc tttgatatcc    95100

tccaccccca accacatcaa ctactaatat gtagtgccat agtctgttaa ttctgtttat    95160

gtggaagttc tctttccctt tctcttttca ctgaaacctt catctctcag gcctccctgc    95220

ttataattct gcacaaatcc ccaagatgaa ccattgcttc tgttttcctt aggtcttccc    95280

tgttttccat cacacaaccc cacaaatcac ttttctaaac taaaaatcta gttaaaaatc    95340

tacaagattc tcctgatata cacagtaaaa aaagatagag tccctgcctt caaaatttca    95400

cttgaaccta ggtgatgata cagaacttgg acacatatat caataaaaat aaatatgaca    95460

ggagcagtcc aagctggttt tgaggcaaag accttaccat actttttcca ttgttcacaa    95520

tagttgccac tttgttcttt acatagtaag cactaatgtc tattgaacta gatccttcca    95580

aaggatttac accctggaca tgagtcatat aagcatgaat tgaatttttc ctcctctttg    95640

gtattgggca acttcttttt aaatatttaa tgactttata aattaactgg tgctaaaagc    95700

tctctttaaa tacactttaa ctgagctctt agtatgtaag gtggattttc aatgcaaaga    95760

accatacagc atgatttcca atttttttgt gaagcctggg gattgatata taaaaagttg    95820

aatgaccagt agcaatacta agttcttttt ttaagttata agttctgtgc agcaaaatga    95880

atggcattaa aagaatggag cagtaactct aggccagaat attagagagc tgtatagcaa    95940

caaataattt acctggtcct gaaaggatga attctacaaa ttgtttcatc ccttaagtgg    96000

aagaagtttt cttctcactg aattgcttcg tttttaagta tgtttctttt aagtcagtac    96060

agagccacct gccctcaggc cagtgggttc agtggtattt atatgaagtg tacttctatc    96120

agtaggtgct tcagcaacca cgtttttttt aatttttctg cagtcaccac tcagcattcg    96180

tggctccttg ttttctgcaa ggcgaagcag cagaacaagt ctttttagtt tcaaaggcag    96240

aggaagagat ataggatctg agactgaatt tgccgatgat gagcacagca tttttggaga    96300

caatgagagc agaaggggct cactgtttgt gccccacaga ccccaggagc gacgcagcag    96360

taacatcagc caagccagta ggtccccacc aatgctgccg gtgaacggga aaatgcacag    96420

tgctgtggac tgcaacggtg tggtctccct ggttgatgga cgctcagccc tcatgctccc    96480

caatggacag cttctgccag aggtgataat agataaggca acttctgatg acagcgtaag    96540

gacgttttac atagctcagg catggctggg cccttgttcc tgcatcagtc agtctctctg    96600

ctgaagggcc ttctctggtc ttgtgaatgg ctctgcattt tgcaatactt tttctatagg    96660

aacacacctt tgattcatta gcctaatcct cattctatgt gttgtaggca tctaactcaa    96720

agataaaatc ccatttttgt aaaaaggtac ttgtctatta attttataat tgaagattat    96780

aaataatctc tttagagaac aatttatgac ggatacatat atagatagat atcagtacag    96840

aaaatgcaag gataatgctg atattagtta ataatagatc ccatttctat gaagaaattt    96900

ggattacttg ccagctactg ctatcttttt caggtcacag cttaatatgt acctattcca    96960

aggaatctta tttgagttgt taataacagc aaacacatat ttagtattta tgacaacccc    97020

atgagatgat acattattat ctctgtttta caaatgggaa aattgaggca tggggaaatg    97080

aagcaacttg ccccaattta ctcagctaat aaatggtagc tcctaagttg aaacggaggc    97140

tgtctgtttc agatcttgtg ctcttaacca ctcactctgc tatctctcca atgtgcagta    97200

ggcttcttat cttgaaaaaa tttagaatgg ctatgtatta ggtcctccat ataaatgaaa    97260

cataactgtt ttcattttta aaaaatattt catctggagt ctatgaatca aaacaaaata    97320

tctgaaatgc aagcattgac acaaacaaac ataaaagcaa aacaatcatt ttacagcagt    97380

tccaaaggtc tacgagtcac taagtggtta gagaaaggtg tctgattagg cttgaaagtg    97440

agatctttct cattcctgga gtttccagga tatctcttta gcccactcac tatgctatgc    97500

tgcattacca atatcagcaa gggctttgac taacccaata agcttcaaac atatgctaca    97560

tgcttatata tttatatttg cagacaatgt agtatttcaa gtgagagtaa agttccatca    97620

aatccatggc cacacatata tttcaatttg aataaatgca tgtgctttta ggtaacatgt    97680

gacctctatg tgtgcatgat acagcttaag cccttctgca aggtattttt cattattgaa    97740

tgagcatgtt aaatttctgt ggaatcaaac tttgcttgca ttttgttttg caattatgtg    97800

tgtaatatgt aaaatactat ataatttata tcagattagg agattatttc atatttttaa    97860

tgaagtttct tcatttaaga gttttttcac catagaaaaa tcagtatcac aataaatcct    97920

aaagtgaaaa ctacaaaact agaggaatta gtggatactt ataagataca atggaaatac    97980

agtaaacata aaattgtggc acaatatatg gtttatatga aaacactgca taactaataa    98040

cgtcatctct atacctgaaa catgtctaca tggaaaataa tttgtttaat ctgacaaatt    98100

cttgtttgac agactatagc acagaaaacc tggttttcga gacttttcaa aaagttgact    98160

ttttacagag atctctcaaa tgggtgtgtc tgttcacata cacatagatg cataatacac    98220

ccatgcacat atctatgcct gtatgtctgt gttttgatac acatacatgc atgactatac    98280

ctatacaact atacaacttt acaaatctag aaatatatat ttaaaatata taccacatac    98340

cacacacaag cagacaaaca tgatagatct agagttgtat agttgtttgt gtatatatgt    98400

gtgtgtgagt gtgtgtgtgt atttctggcc tgcatggaac caacatagtg ttttaaattt    98460

gaattagttt ccaagtttta aaaataagac attttctcac aaaaataaat acacttgtta    98520

tgcatgagtt catgtttttg catggcaaca atttctagag ctgaagagag gtcacctctt    98580

tcagatgtag cttgcattct ccatttcact aattgttcct ttcaaactga gtcatttatc    98640

atcatatgct ctgctcagtt catgaggtct tccttggcag taagagacaa ccattacagg    98700

agcttcatta atgttgttcc ctcaataaaa agtaattcca gaaatttatc agagaatact    98760

gagattctac ccctttagat acacagcact acagcacttt cactgttttc atgtaggact    98820

gtcacatgac aaactatctg aataaattga acactcagaa aggcagagag gtgatgatag    98880

tgatgatata acaaaaaagc agctagcttt attttttatc tcataaatat taattccttt    98940

aatcctcaca agaatatgaa gcaagcacta tgattatccc cattttacca atataaaact    99000

gagacagtta agtagctctc ctatgatata cagccagtaa gtagcagagc cataatttga    99060

acccagcaat ctaggctcta cttttaatta ctcactacag ctatataagc aagattttat    99120

cttataccta caatttatta ggattctgtt cttaagacat taattgattt tttttttagg    99180

gcacgaccaa tcaaatacac aagaaaaggc gttgtagttc ctatctcctt tcagaggata    99240

tgctgaatga tcccaacctc agacagagag caatgagtag agcaagcata ttaacaaaca    99300

ctgtggaagg tatgtaataa tcttctttta ctgtacagat tcttaaataa aattaacata    99360

aatctggtca accttaaata ggcacatgaa attcttagga agaattcaga gaccataaaa    99420

tggttttaaa tgatggtaaa gataaccaat ggatactgat ggaattgttt ttatgtgctt    99480

aaaaatggat aaaattattt gctattaaac acagacattg ataacatggc aaaaatgact    99540

ttgcaaaatg aaaaaaagaa aacccacaaa gacagatgtt gggtgatctg acctttcaaa    99600

gataagtgat ttaatagtaa ttgatgcaga aaacaaggtt aacccagagc tacgtgattc    99660

tgtcactata taatcttaca aattacatat tcgctcaaaa attgtctctt ctaataagca    99720

aagatagtca aagggtgaca actttacaaa ctgtgctggc ttctaccctc tcccctgaca    99780

atatgcccca ggtcccacct ggtccctggg tctaacactt caccccccac attcccattg    99840

tgggggcaaa gtgtctactc atctcctaaa taaatggtga gaagtaaatg ggctaatggt    99900

gtgaaatgtc tatttcatga gtcctccata aattatttct agttgcttgg ttctaggatt    99960

gttttcacct gtgaactatt acagcaagag ttttttctgg acagaatagt ctcatcttat   100020

tgttgtcatg ggactaaaaa cacaggtgaa aaatatgcat attggtggaa aacatacatt   100080

tctctgttaa ggaaacatag ttctcctgtt taccatcaca tgttaggtgc atttttctct   100140

gaaagatgcc cacatatgtg cttgcagtca taaatttcac ttccttaccc tctcttatgc   100200

ttcatctagg caacgaacat gtcataatag acttacataa gaggctatgc tttcattgaa   100260

atagtactgt taaattttca aaatctaaac tataaacctt gtttcaatat tagaatgcct   100320

gactgatttg tatctggtta ggagtgaaac agacaaatgg ctgactccat gttctctgct   100380

tttttctccc agaacttgaa gagtccagac aaaaatgtcc accttggtgg tacagatttg   100440

cacacaaatt cttgatctgg aattgctctc catattggat aaaattcaaa aagtgtatct   100500

attttattgt aatggatcct tttgtagatc ttgcaattac catttgcata gttttaaaca   100560

cattatttat ggctatggaa caccacccaa tgactgagga attcaaaaat gtacttgcta   100620

taggaaattt ggtaagtctc ttattgtgtg ttatgtactc atagtttctc tttttagttg   100680

tcatcattgt catttcatat tttttatgtc agatgaatct gcagcctcag aattatgcat   100740

atccagaact ttccatatga atggatgtgt agagtcaagt ttctggttat gtcttttaaa   100800

ataattgtgc agtactgttg aggtctacaa ataacaatac tatttctata aaaggttacc   100860

atcttgggag ttgataatga ttttttctgc cagcatattt cttgggagca acacttaaca   100920

tttttggttc tttctcacac cttcctaatt acattgctgc tttcttgtaa gtacacacct   100980

cacatatttt cagaaaacct atggatgtat tgctttgaca taatagtagt gaagtgtttg   101040

ggtcctcaga gtcccaaagt cctgggtttg aatgctgatt ctgcattata tgagtgatat   101100

gcccttggac aaatatttta actctgtagt atttaatttt atcatttata aaataatact   101160

tcattataaa ataattattt ataatataat tgtaactgta tttcatttat catattcttg   101220

ggaggattaa atgctttctg cttattagcc tggcatatag taaatacaca ataaattaaa   101280

gctatcatca tcatcaacat cattgtcatc aaaacttcaa agacttaatg aaacaagctt   101340

taaaaacaac tattttgaga aaccaaaatg gttgaactgg acatagaaga ctcaaggata   101400

ggcaagaagg tgatcaacag acttctggaa gatataagat ccaattagta aaattgatgc   101460

cagagtgatc tctaaaatgt acagtgctgg tcacactaac tcagggtaaa caaaatgcca   101520

gtttttgact atggatgtga ggcaggcacc agttcatttt tagggccaga gaatctcagc   101580

ttatgactct tcataaacca tgaataactt tgggtatctt tgtcaatgtc tatataagat   101640

aattttgctt ttgctgtggt cccaaacaaa ttgacatttg aagaccagaa gttcttttct   101700

gagtctgtct tttcttctaa attgtctaca aatattccca atgtttttcc ccatgtgctc   101760

gctgagttag cattcttctt cccttctatt tatctttgga aaaaggcagg aatatctagt   101820

ttctaattgt tggtggagat ccggatcttg caaataagta ccttctcact gagacgactg   101880

catccctgtg aactcagaaa ggatttacct ggtcacagct attaccacaa cctcaagtcc   101940

agctgctccc tgccaatctt cttgatcctg cattatttga aaattgactc ctgcagttat   102000

agacctaaac atttccctta gaatcttctt tggtcagatt ccttgagtca aagtgtaccc   102060

aaaggattca tttcggtgtt gcctttttaa gtgagtcctt tgataccagt atcatgaatt   102120

aatgatattt tgcaatgcac ttttgtgtca aagctttaga agtattactt tagctgccac   102180

attgtcaatt aaatactttt ttctcttctg ctgataaatc tttaaagagt gagtcaacat   102240

gttctttatt actctaacag tagtcagatc agaaaaaaaa agactggctc aaaatttcag   102300

tatcaactta tgttttcttt ttatcttctt ccagaacaac tttttgaccc acataaattc   102360

tttgaaaata gtgactgtgt caattaccaa atgttttact cttctgaaat tttaatatgc   102420

tattctaaaa tgctgtctaa aaatgatgag cactgacagg acagttagag cttttcaacc   102480

ttttgatgct gatatgggag ccagggaaga gcaataccta atttacagga ctaagttaga   102540

taagaatatc catttataaa gtatttagca aactgtctgg aacacagtaa atgctaagca   102600

aacagtgatt attatcattg tgttgatttc ctgttttcta atattaacag aaaaacatta   102660

tttttctcac ttaggtcttt actggaatct ttgcagctga aatggtatta aaactgattg   102720

ccatggatcc atatgagtat ttccaagtag gctggaatat ttttgacagc cttattgtga   102780

ctttaagttt agtggagctc tttctagcag atgtggaagg attgtcagtt ctgcgatcat   102840

tcagactggt aaacataaac taaggttgcc attatattct ataataaagg ggtatttctt   102900

tggttttgca ttatttttaa aaacttttgg gaatttgaat caaaaggcaa gattatatct   102960

tgatatctag taaaataaaa tccattcatt gacaaatgca cttaaagaac taaaaccaca   103020

tgaatatttt tacaattttt gaagacatgc tcaattctaa tttgaagtac acgctaatat   103080

aatataaata ttttctatta atatagtaca ataatttatt tcagagtaag aagcttgtgg   103140

cttacagaat ttcaatgatt atatgttcat aactttatga atttggtaat taaagatcaa   103200

attgttatcc cccaaaacaa ttgttgtctg atcttaacaa tataaaaaca aataaagact   103260

ttttaaagca cattcctcta atatgctaga ttttatctaa gtgtcggcat gagaaaatgt   103320

atgaaagtat tagaaagtag aattaaggat aaattatcaa ttctaaaaga aaaatatcac   103380

aaattatgat aagaggtttc tatagcaatc ctgaactaaa agtacatagt ttcttcataa   103440

tatgtgttgt aattttttgt ggcaagtgga acaaaataac agagatattg aaaattgatg   103500

aaaatgaaaa ataagaatat tttagctgga taataatgac aatattatag gacttaaagt   103560

ctgctttacc ctttgaacaa aaatcaagat tggaaacatt gaaaagattt tcatagtgat   103620

taacattaaa ctttatattt gcttttagct ccgagtcttc aagttggcaa aatcctggcc   103680

aacattgaac atgctgatta agatcattgg taactcagta ggggctctag gtaacctcac   103740

cttagtgttg gccatcatcg tcttcatttt tgctgtggtc ggcatgcagc tctttggtaa   103800

gagctacaaa gaatgtgtct gcaagatcaa tgatgactgt acgctcccac ggtggcacat   103860

gaacgacttc ttccactcct tcctgattgt gttccgcgtg ctgtgtggag agtggataga   103920

gaccatgtgg gactgtatgg aggtcgctgg tcaagctatg tgccttattg tttacatgat   103980

ggtcatggtc attggaaacc tggtggtatg taaccagatg ttcatgcatt ttaatttctc   104040

tgtggaaatt attttgtgat gatgtgatct attattttta taattttata attaattata   104100

tctacaatta ttaattgcaa aagaatagtg ataattttaa tacaagaaag aacaggaaag   104160

agaacgaaat tttgtattag ttttcctagc caaataaccc atatttatat ttttcaaaat   104220

cactgcctat tcattttaag gcaaaggttt ctatcttttt ctctaatttt gaaagtgatg   104280

gcatatgctc tcttgaagct atactagtaa ataaaatata attaagttaa taataacaaa   104340

aatgaagtta ataatggacc aaggcaaatg aaaggactgg tcccgcacct tatagccatg   104400

tgtaagacta gcctctatag caaggatcag cacctatgcc ccacagacca aagccagtcc   104460

aatgcctgtt attgtgtggc cctgggagct aagaatgatt tttacatttt taagtggtta   104520

aaataatcaa aagaagaata aatgacacat gcacattata tgaaatgcaa attttagtgt   104580

tcataaactt tattcaaaca taggaatgtc aattcattta cgtatcttct atgactgctt   104640

ttacattaca gtggcagagg tgaatagctg ccatagaaat cgtatgccca ataaagtcta   104700

aaatatttat catttggccc tttacgaaaa agttttccag ccactggcct atagcatcgc   104760

gtggacatag caatctgcct actttttgaa ttagtgtttt cttggcttgt actttttttt   104820

tatttttttt cttccttata ctgattagtg aaaactttca agcttacaag caggagaaaa   104880

ttgggataaa atgctcttct atgagccact catctcaatt ctcaaatctg ccacgttgac   104940

ttgtcacagt tggtcagctt gacatcaaat ctctcatcag gtatccagaa ggtgggatat   105000

ggtaacagcc atatggtaag tgccttcact tcccactgag ttgaaaaaaa ttactaaaat   105060

attgttgtcc ttgtaaccac cataaaaaga ggattcagaa gtcaggacag aaacttacat   105120

tcatccagtc acacactaaa tgatactgtg ccagacatac acaaaggcat ttatgcagca   105180

caaattctag atttttactg cacaaaaaat atacatcctg gattaccatt ctataattgt   105240

tgatcaccct caagttgtag taataaataa gcttcctagt tttatatagc cttacaaatt   105300

ccttccaata tggaatgaaa tgcacattct ctttgtttct tcttctctgt tttgtattta   105360

taagctccta tagcaggatt tgcttgtgta tttttttttt ttttgagatg gaatctcgct   105420

ttgttgccca ggctggagtg caatgatgtg atctcggctc accccaacct ccacctccca   105480

ggttcaagca attcttctgc ctcagcctcc tgagtagctg agattacagg tgcatgctac   105540

cgtgccagct aatttttgta tttttagtag agacaggttt tcgtcatgtt ggccaggctg   105600

gtctcgaact cctgacctca ggtgatccag cctccgtcgc ctcccaaagt gctagaatta   105660

caggcgtgag ctactgcgcc cagctgtgca tttcttctta caaaattttg acataaaatc   105720

gtgaaattgg gaaaggtata acttgtgaaa acatgccaca tcaaagccaa taatcacaaa   105780

taatttaaat gtttattatt tattcaggca aattcaaagg gaaaggcatt cccttggctc   105840

tcaccacatt ttccactcaa tattttttag tatcttctct gtgaaaagaa aggtatttag   105900

gtattgttta gataggaagg cattgtttag gtattattta gggtggaaga ccaaaaccaa   105960

ttacccatgg tctaatcctt gtttttaaga tgcttattag ggcacagaaa agtggaacac   106020

aaaagttatc agacaaggaa gaagtgatga gttctaccaa taaggttaaa taaaatgctt   106080

ctgacactta aagaaagagt tctagattga gacttaaggg aggtttttga agtgggcctt   106140

tgaacaatgg ataatataat atttgatcat ggacactggt gtgagagtta tgttttcctt   106200

tgaaaggcaa tatagattta tagtaaaaaa cagaggggat atattggtga gtgtttcatt   106260

cgtgtagaat tagtgttaac taactcatat tattattctt taattattaa ttcttggcaa   106320

agaaagtata cagaagaaaa ttcataaagt tgataaccaa ctcttgacta atggaggaac   106380

taccaatatc atagaattaa aatttaagga aaaaaatata ttcctgatat agccttccac   106440

attagagtta tatgctaaac tggcttctct ttttttatat ttctctaatt tattcttttg   106500

atcattttat tgccagttaa ttgaaatggt taaggaccat aggtttagga aaacatttgg   106560

aaaaataagt tttagtcagc tcgggtctat atcaggaaac ttgcgaagac cattaatcaa   106620

aatgagactt tgaatcaagt atacatttta ttaatatttc ttctcttgtt taacatgata   106680

atacaaagat gatacaaatg gactttattt tgatttgtga tacccactag gttatagaaa   106740

tattagagac ttatgatttt tgaaggaaag aaagttgtca cagcagctgt tctcaacgaa   106800

gtgagaaccg catgagccac tgcaccctgt taaaatggtt taacgcttga acagattaag   106860

gagactaaag cagtaaaatg gaccctcaga tcttcaccaa tattcctatt aaaacaaata   106920

tacacaaaca tgtatttcat agtgaaatat actttttcat tgacaactat taaaccattt   106980

cagggatttt tagcaattat caaaattgtt cactatgatt cccagacctc cgacctccag   107040

aattttctcc taaatcagac ttattgagac acacaatttt agcctgctgt ctttacttac   107100

atctcagaga aattgtttta ggtatgacca aaatgaggga tgagtacctt ctcttcagtt   107160

aggtcttact tcgattttta aaacatgagg tagatgattt gggccatgaa aagacttaca   107220

tcaaatgcca attcaatttc cttttttgtt tcctggataa aacaatgttt aaatataatt   107280

tacaatttac atgtttcctg ccctctgtga acattttttt tttttacaat gtggagttga   107340

cctgcacttc tacttcagtg agaaaaaaaa ataattaact cagaaataaa actttgcttc   107400

aagagaatag aaattgtcct gacctttttt gtaatctctt ctagggcaaa cataataggc   107460

aatgaagcca gccaatcata atgccattat tgcatgtgaa tcaggttcaa ggggcaggtc   107520

cttttctgtg ctttaaaagt cacattaagc agtattctag cacgcttctt ggacagaata   107580

ttttattaca ggaactttgt aagtattatg tgttccattt gttagaacaa gtgacattta   107640

tcttctggta aagtgaacaa agatctttag cacaatagaa aatagtcaca attgttttgt   107700

tctacctgtt tctcacaggt aataaagagt aatgatagat gaatgctagg agagtttttt   107760

gggttcataa aagagaactt gattaaggca ctactgctac agaaatgaac ttagaaatga   107820

tgtaatgata atggtgaggg atcattctct ctgctcccca tggtaattct tcctgggtat   107880

ggctgaccct ctgctgctga gtctgcaggg gctagtctag ggatacagtg atgaggagtc   107940

taccctcgcc tctgtctctc tcatgtggtc ttatccgtgt gtgaaaaggt gcagaaatct   108000

tcgttgctgg tttgtattgt ggcctatatt cggaaaagtg tacttatttt attttatttt   108060

ttatatttcc tgtctcccta tttctctacc ccctctcccc accctgatat aggtcctaaa   108120

cctatttctg gccttattat tgagctcatt tagttcagac aatcttacag caattgaaga   108180

agaccctgat gcaaacaacc tccagattgc agtgactaga attaaaaagg gaataaatta   108240

tgtgaaacaa accttacgtg aatttattct aaaagcattt tccaaaaagc caaagatttc   108300

cagggagata agacaagcag aagatctgaa tactaagaag gaaaactata tttctaacca   108360

tacacttgct gaaatgagca aaggtcacaa tttcctcaag gaaaaagata aaatcagtgg   108420

ttttggaagc agcgtggaca aacacttgat ggaagacagt gatggtcaat catttattca   108480

caatcccagc ctcacagtga cagtgccaat tgcacctggg gaatccgatt tggaaaatat   108540

gaatgctgag gaacttagca gtgattcgga tagtgaatac agcaaagtgg taagaatgct   108600

tcatatactt tgtgtttcat attaacaatt agtatgaaat gaatgaaaat ttcatatttc   108660

tattgtcata agttcttctt aacattgcat gtagtgatgg atagtttttg tgcgtgactt   108720

tacacaacag cttcctgaag attcatctgg taaagttttc ttactagttc ttaataattg   108780

atttaatctt acttagctgt atgagaaagc tcaaaggtat ctttgagcct tcccatgctt   108840

catcccatgt ttcctgtcag ttgaaaagtt acacagtctc cctccacagt gcctgtttga   108900

atccacctct ccttttcatc acctttcctt tgtactcact actttttgcc taaaccattt   108960

caagcagagt ctcaactgat gcctctgctt ccattttgca tttactctag tttacttatt   109020

tgattatttt cgctcatgca gattcagtcc taatcatttc actctcatga tgtatccatg   109080

atccgcaaag tatcgctctc tctctctctc tcttcttttt tttaaaaaac ggagacaggt   109140

ctcactctgt tgcccagtct ggagtacagt ggtgctatca tagcttactg caaccttgaa   109200

ctcctgggct caagtgatcc tcctgcctcc acctcctgag ttgctgggac tacacaccca   109260

tgccacaaca cccagctaat ttttttaaaa aagtttgtag agacaaggtt tcactatgtt   109320

tcccaggctg gtctcaaact actggactca ggcaattctt caaacttttt ccccagttgc   109380

tgagattaca ggagtgagcc accacgcctg gccatcccca aagtctcgaa ttatgtactg   109440

tgcacaaagc cttcacacta tggccctaac cagctttgac cagctctatc tcctagtgct   109500

cacccataga tttttacctg taccaaacca atttcctttt aggtcataaa cactctccac   109560

actttgcttg ggatttcctt ctccagtcaa aatccttcaa ggcatcaccc ttgtatttat   109620

catctattaa attgttaata cttaaatcgc agttgggtca gggttaaatg aattaacacg   109680

ttaatacatg taaaatgttt agaaccatac tcaatgttct caaaatgtta tttatttcat   109740

ccctcctaat ttctccccaa atggatgtag tcccttctca tttttgaacc gcaaacaatt   109800

ttatacttct tcctggattc agtaatctta aattttaatt ttttgagaaa ttatggtatg   109860

catcaaatag tactgtaaat tcattgagaa caggaactct ttaaaacctt tttttgtgcc   109920

ctcctctccc acccttacct gcatatttct agtgagtcaa ggtatgtatt gagttttatt   109980

tttattgtga aatataacaa ccgtattaca aattactttt atgagattgc tttcaagtct   110040

taaggcatca tttaaaaata atcttttgtt ttctctagct catgttagaa agtatttgac   110100

agatatttac caaatatctt ctatctcctt aacttactaa gactccaccc tccatgaatt   110160

tatagtggac ttggaaaacg agattatatg gaataatcat gactgatata tatatatata   110220

tatatcagta aaatgctcag gaggctgagg catgagaatc acttgagctc cagaggcgga   110280

ggttgcagta agccaagatc gcaccgctgc actccagctt ggactacaga gtgagactct   110340

gtctcaaaaa aaatcaatac ataagattaa attaaataca taagattaaa ttaaattaaa   110400

acaaaataaa ataaaatgct ctatatttaa ttgagtgaat aaatgattaa ataaataaat   110460

catgatatat gtttctatgt agccaaggac attttttcca agacggtaaa gtaaggaatc   110520

aaatctagtc atccctcgat atctatgggc gagtagtttg aaggcccccc acagagacta   110580

aaatctgcag atgctcaatt cctttatata aaatggcaca atgtttacca taaaacctac   110640

acacatcctc tcatatgtac actttaaatt atcttcagat tacttataat gtaaaagtaa   110700

atcactgaca caatgtaaat atttgtttta ctatattttt tatttgtact atttttattg   110760

ttgtattttt atatttattt tttccaatta ttttccatct gtagttggtt gactctacag   110820

atgtgggacc cagggataca gaaggccagc tgtattttat ttgtatattt taaaatgttc   110880

tacatggaag aagtaatact cccaaaattt taaaaccgtg ttcatttcag cttaaagtta   110940

gaaaatcaga ttccacgtat gccttttaag gagcaggcat ctaggtttag tatcatatgg   111000

aaagggaaac taactcagtc acctattttt ttctaactaa ctctgtcacc catttaaaga   111060

agattaaaat tataaactcc aattgcctgg cagacagttg ctctcagaat aaaacttgga   111120

ttctaggtgt taaagcactt caggagctgg ggaaagtcaa ccaaagactt ctgaaattat   111180

ttcttaacat ttatgaggaa ttatttctta cctgttcatt tttctttcat ttaaagtcaa   111240

tggctgacct ttcatggatc tccttagctg ctgacaaaat tcttattctt agtatgttga   111300

gttgcaacat ttttaaggga accttataga actttccatt tagcacttca ttttctaact   111360

gaaaaagcag actcattaaa aggaagtgat tttattcaca gttataaagc tagagttata   111420

cagttataaa tctagagtta tagagttata cagttataaa ggcagagcca tgtcaagagt   111480

cctaggcttg tgacttatag ctcaatggaa tttctacctc tcttgtcctc tctttgtcca   111540

tttgaaacac aaaacaaaca ttcctattgg acttaataat ttgtctcccc tggggtataa   111600

agccatgcag ctatagaatt tatatatctg tggcatgcag atgaaggtgt gttgtcataa   111660

tggttagcta tcttttataa ctagtgattt tatttgtatt ttataactga aatagattat   111720

tttaaccatt cataaaatta ctctgtcact tattccatga gcccttccga aagcgtatga   111780

aatctagtgc cctataaact gagttgtcta aaaatcattt gatgttaata ttctaatatt   111840

cttgattttc actaattttt ttctcattac ataatggtta tatctatatg ataaaagagt   111900

gtacattctt actctattac atttccatgg tatgcacaat taaatataca ggagtttgtg   111960

gctaccttag aggttgtagt aacagataca caagctagta tttttaagtc atgtagcata   112020

gtgtttgaat tagcaagcca ttttaaaaaa agtgtttgtt gtcatcgatt tctgcatcat   112080

tattattact taagaactca ggttcttagt gctactgact tctaattatg aactttgaaa   112140

gtttaccctt cttcataaaa aattttccat gacgtatctc aaagtatgtc atattaagta   112200

tagacaaacc tacctgaaaa tataagaatt gagaaataat gaaggttcaa gatctagagg   112260

aaatttgttt gataagatat taagctgtgg tcaactataa aaaccttaca tctaaggtct   112320

ttctttccag cctcttcaga ttaaaatgtt tccagtttaa attctgtcat ttttgttttg   112380

ttttgttttc ccattcagat cactaaaata gtgtacattt tatttatttg tctaaaatgt   112440

ctttaatcct cctatgctaa cttttcctgc tctaattctc ataatcttca tctcccactt   112500

gagttcccag agtcttgaac tgtgaattcc ctcttttgca acttttattt ttttcgtatc   112560

tgagatgcct ttgaaatagt gatggttgtg tttgtgatga gcctggatga gccaaagagg   112620

caaattgaat tacccaatag aaagtaactc ctaatttata tatttatgtc attaagtctt   112680

agccactacc ttgggatata gttaagaatg ccacttttta agatagaata tttgcctcaa   112740

atcttagctt ttgataagac cttgagcaat ttacaaaaac atttttttca gtttatttat   112800

gtgtaaaata gattgtaata aagattatat gattctcata aataattaga caaatgctta   112860

ttgaaaagtg ctcaatgtac aattattata agtatggaat tgagtgctta tatacacact   112920

gtaagtagct attggttaca gattgaattt aaaagagata gcgtgatgaa gatcagtgct   112980

tcagaatttt agtgtgtgaa agacatactt ggggacttta ttacaaatgc ctgttctgga   113040

tcatatcctt tgaattgttt gcctaaattt ggatgcaact tcagaatcat taacaacgtt   113100

tgcagcagct actgatcaat agagactact atgaacaatc atactccaac aaattggaaa   113160

acctaatgga aattgataaa ttactcaaca catacaactt gccaagactg tatcatgaag   113220

aaatggaaaa ctcaaacaga ccaataatga gtaacaagat tgaatcagta ataaaatctc   113280

tcctagcaaa gaaaagtcca ggaccacatg gcttcactga tgaattctac caaacattta   113340

aagaagaact aatactaatt cttcttaaat tattccaaaa aaatcaaaag gaaaggaatt   113400

cttctaaatt cattctacaa ggccaatatt accccaatac cagaacaaga cagggacaca   113460

cacacacgaa aagaaagctg aaggccacta tccctgatga acacagatgc aaaatgcccc   113520

aacaaaatac tagcaactca aatccaacag cctatcaaaa agattattca ccatgctcaa   113580

ctggaaatcg tcccagggat gcaaagatgt ttcaacattt gcagaacaat aaactttcta   113640

tattatatca acagaatgaa acataaaaac catataatca tctcaataga cagagaaaaa   113700

gcattttata aaatccagta tcctttattt gataaaaatt atcaacaaat taagtataga   113760

agaaacatac cttaatgtaa tgaaggccat atgtaacaaa cccacagcta acatgatact   113820

aaccagggaa gagctgaaag ctttctctcc aagatctgga acaagataag gatgcccact   113880

ttcactactt ttattcaaca tagtaatgaa gttctagcca gagcaatcag gcaagagaaa   113940

gaaataaagg acatttaaat tggaaagaag gaagtcaaat tctctttgtt tttatatgat   114000

ctgatcttag atatagagag ttctaatgac cccatgaaaa aaagtagtag atttcataaa   114060

tgaattcagt aatgttggag gacacaaaat caacatgcaa aaatcaatat tatttctata   114120

tgttaacaac aaataatctg aaaataagaa agcaatccca tttacaatag ctacaaaaaa   114180

taaaatacct agaaataaat ttaaacaagg aggtgaaata tatttacaat gaaaactata   114240

aaatattggt gagagaaatt gaagaggaca caaaaaggga aagatattcc atgttcatgg   114300

attagaataa ttattatttt taaaatgtcc atattaccca aagcaatcta caggtttaat   114360

gcaatcccta tcaaaatacc agtgacattc tttacagaaa aaaaaaaaaa aagtcctaac   114420

atttgtatga aaccacaaaa gaccctaaat agcccaagta acctggaaca aaaagaacaa   114480

agctgatggc ttcacactaa ctgacttcaa aacatactat aaagctatag taaccaaaca   114540

gaatgatact gacataaaac agacacacag agcaatacat aagaatagag agcccagaaa   114600

taaatctaca catatacagt caactgagtt ttgacaaggt tccaagtacc tataatagag   114660

aaaggacagc ctctttagta aatggttctg ggcaaactga atagccacat gcaaaagaat   114720

gaaattagac ctttatctct tactttatac acaagtcaac tcaaaataga ctacttaaat   114780

gtaagactga aaactacaca actattagag aagaaaaaaa acagggggaa agcttcatga   114840

tgttgttcta ggcaaggatt tttttggata aaacctaaaa agcacaggca acaaaagcaa   114900

atatagacaa attggattat attaaactaa aaagcttctg cacagcaagg caaacaatca   114960

atagagtgaa gagataacct acagaatggg aaaataaatt tgtaaactat gcatctgata   115020

atgggttaat atctaaaaca tacaaggaac tcaaacaact caacaacgac aaaaaaaaca   115080

aataattcaa aaatggacaa aagacctgaa tagatatttc tcaaaagaag acaaagaaat   115140

gccaacagat aaatgaaaat atgctcaaca tcactaatca ccagggaaat gcaaatcaaa   115200

cctatcttga ggtatctcct caccctagtt aaaatggcta ccatcaaaaa atcaaaagat   115260

ataagtgttt aaaggatatg gagaaaaggg aatccttaca cactgattgt gagaatgtaa   115320

attagtacca ccattatgga aagtaatatg ggggttcttt aaaaaattaa aaatagaatt   115380

ttcatatgat ccagcagtcc caatactaag taaatatcca gatgaaatga aatcagtatg   115440

ttgaagagat acagtaaaca tagaatactg tactcctata tgtttattgc tgcactgttc   115500

acaatagcca agttatcata ttaacctaaa tgatcgtaaa taaataaatg cataaagaaa   115560

atgtacataa gaaaaattga acgccattca gccataagaa ataatgaaat cctgttattt   115620

gtggcaacat gaatgaacct ggaggacatt atgttaagtg aaatcagcca ggcacagaaa   115680

gtcaaatatc tcacacatat gtggaatcta aagggttgtc atagaagtag atagtagaat   115740

agtggttatc ggaggatggg aggcttggag gagcgaggtg tggggaaaga ttggtcaaca   115800

ggtacaaagc tacagtgaga tagaaagaat aagttctggt gttctattga atcgttggat   115860

gactagagtt aaccataatg tgttgtatat ttcaaaatag ctagaagttt ttaaatggtc   115920

tcctcacaaa gaaatggtaa atgttcaaag ctatggatct gctagttacc ctatttgata   115980

attatataat gtatacatgt atcaaactat cacatgtacc ccataaatat gtacaattat   116040

tatgtgtcaa taatttttaa aataaatgat gccaacttaa tccctagctt acttggattc   116100

aggtttctga gatattattt tctttattca ggggctatgg gtatatttcc ccttttgctt   116160

gtttaagaac ctgcattttg agcaagggga aaaaacatca ctgacctttg atatctctcc   116220

ctctcttctc cctacccaaa aaccctctct tttatgacct agcatcctgg tttctcaaca   116280

gagtttatgg agaattttca gtgctctcct agtataagtt ttcaggttga cagatttcct   116340

caacctgata gacagttaaa aatacactcc agaatcaaat caaaatattt tacagtaaaa   116400

cctcttatca gaaaataacc aaagagatga gttaaaacaa acggtttagt caaatatctt   116460

aaacagttct gaggaaacaa atggaaatag aacaatagca cttctctgaa gagatagtca   116520

gtgtcagaat caagaaagac atgctgttat ctcaaaggta cccatgagaa taatactctt   116580

ttcactgttt ctaagaatgc aggcactgaa ctgatggctc ttctcagagt cagccttctc   116640

ctgaagtgca atgaagccct ccaagcacac tccaaacatt aacaacacac tacacaggct   116700

tttttaccac tggcagtgaa gtgcttcctc attagaagcc ttaaaggaag tatgaaatgc   116760

acccatttgt caataaatat ttattacacc ttactatgct ctaagcactg tgctaagaat   116820

tgctgaggga aaaaagatca tgttctcaca cagctgcaac aatttaatat cgggattaac   116880

ttgaaagtta aaatataagg gctcagggtc tagatatata agattgtgag ctgatccaag   116940

gatgtattag tttcttacgg ctgttgtaac aaattagcaa aactcagtgg cttacaacaa   117000

cagaaattta ttcttttgcc agttctggag gctagaagtc tgaaatcaag gtctgagcaa   117060

ggccatgatt tctctaaagg ctctagtaag tatcctgcct tgctgctttc taactttgga   117120

ggttgttggc aatccttgca gcttgcagct gcatcatccc aatctctggc ccggtactca   117180

cgtagttttc tccctgtgtg tctcggtctt ttcttcttat aaggacccca gttatattgg   117240

atttggaccc acacaatgac ctcatcttca ttgtgtctgc aaagaccata tttccaaata   117300

agatcacact caaacatgcc agggttagga cttcaacata acttttggag gattacaatt   117360

caacccacaa caaagaattt tgacttagaa gactagatgg ttattgatac aattaagaat   117420

acactgatgg aggagaaaat tgaggaggta ggggaaatac agagtttaat ttggtggcat   117480

cataaatttg aactacttgc agtacaggca gtgaacctga acaggaggta tatggaaaga   117540

taaatcttaa ggaaagaaga aaagtcagag ttgtagatag gttgggattt tgtatgctaa   117600

ctttcattaa tcacgggatt gtgtaggggt cagttccctg ggaaaccaat cctgagagag   117660

aaatctgaga tttactgaga agtgttttca ggaacgaaac gtaacatctg taaaaagtga   117720

ggcatgcaaa attattgggc agagagagaa gttgaactgt taaaattgca acagagattt   117780

cggctgatcc tattggcatc tctgatgctg tgacaaccct ctggagtagt tccaaaacaa   117840

agcaagaggg tcaggccttt cttctccaca ccattcattg gatgcaggct ctccctttac   117900

ctttccaggg gagaagggta taaccttggg ggaagcacct cccttctgcc acgataaggc   117960

ccaaagaggg attcagatgt gagccttcag catccaacac ttttggcagc tgggggaatg   118020

agcagcttgc tggaaagcag gatgtggaca gtgccttaga gcatctactt catgacagaa   118080

ccacagacag cagctgagaa cagcggatca aacacatttg agaggtggat gcaaaagaag   118140

aaagcacgca cacacacacg gataaaatgt atacagtagc ccctttacac acattatata   118200

attttcgtct ttgtgacctc cttaggaagt aaatataatg catctatatt tgcagatgac   118260

tgcgattcta aaagattaag aaaagatttg gttagtcatg gacgtatctg ggggtctttt   118320

taaatttaaa ccccaagctg taatcattat actacatgcc atagaaaggc aagaaaatga   118380

gtagtagtat aattgttttc tgctatacct ctgtaatggt gtaattcagg gtgaaatttt   118440

ctgttgtaat ggtattgtac atttgctgat tcattgggat tctgatattg tgcttctaat   118500

ccaccttaat gctgactgat taggttatag tctaccttgg taataatgtg tgatttttat   118560

attttaggtg tttaaatttg tttcttcaaa actatcttat tcccttcttt attgaaaagt   118620

aaaactgatt ttacttctag aatatatttc tttctcaaga ctacataacc ctttcctttc   118680

catttattca gtattaaatg catattttat acattatggt atttcatgtg tatctgtata   118740

tttatttttg catatattaa tgtgtctatt ttttcatgca aattattgat aaatatgaca   118800

aactcatcta gaccaaattc aagttcttgt agcttctgcc tgatacattc attcttctct   118860

aggtgaaaac cttgctgagg taactatgag gttcttagtg ctactaagac ttatccagct   118920

ctccctggct tgttgatgaa attggcaagt gactcagaaa tatcactaaa gtccagatca   118980

ttgcctttaa agcatctcct ttgtcatgac ttattatgtt attacagaaa agtattaaat   119040

caatttggca taattttttc tacacatcac tttgctctct ttgaaccttt gtgttctctc   119100

aggacaatgt attaagtaga attgatttat tattatatta tctttcacat taaggctata   119160

ttaggggcta gggagtacac ttactgccac accaaggtac acatgttaag atcttaacta   119220

tttgaataaa cctattttac ttaagggtac atgggtaatc cctatttttt tgtgtgtgtg   119280

ttttgttatt tttggctatt tctgagtcag gactctgttt aactgcatgc aacagagact   119340

taactacatt ggcataactg gatagaacat tctgttttca tattttaaaa catccacaga   119400

tcagcagtcc acgtggcctc catgtcctag gctccatctc ttctcccttc tgccaatctt   119460

cacatgtgtt ttttcttcta tattaatgcc tatgattaga ggtgactgtt ccacctacag   119520

ctttatatcc aatacccagg tagagaaaga aatagaacga agcagaagta atgactatcc   119580

cacttgcctg aggaagggca aaactttccc agagatcctt atccaacttt ggcttatgtc   119640

ttattggcaa gaacagtgtg acatggccac ccctaacaac aaggtagcct ggctgaggca   119700

ggacatttat ctgggcatat tgctaccctg aataaaatct ggattctctt ggtaagatac   119760

cttggaaggt attaacaagg tcaggcatgc ttctccaata ttactactgc tactaattat   119820

tattattcct ttatgaaaat gtcaaaagaa ttgaaggatg gtaattttct attttaagag   119880

atgcagttac taggcataat ttggaataat atgcatcaat tgtaatgtta tactttgaaa   119940

catattgtat aaaattacca aaaaacaaaa gttaattttt acttattgaa ttagaaaata   120000

tatatgaaaa taagaatatt ttaagttaaa taataaaaaa ctaaatatcc aaccattttt   120060

aatctgcaaa aactagaaat ttcatgtggc tcaacataat acaaaggcat aagtaaaata   120120

taaacttcat tctacctgta taatcttatt tcttaattac ataaatatta tgttactgaa   120180

cacagatatt ttattcattt cttttatttg tgcatagtag agaacacatt aaaattttct   120240

atgactctct gcccagaatt ataataggca tagagttttt ctctcctaaa ttacactcat   120300

gaaatatttt tggcccccta taaatattga gtcccccaaa aaccacacta aaaacttcat   120360

gtacttcaaa ggtaaagggt gattgatcat tgacaacaaa aagtatacac tctaatagct   120420

tgcaccttag gtaaatatac aaaaaattat aacacagaac aaagcaaagc acaatccgta   120480

acaggacact aaactagtcc attgaggatg cattgagtaa ggggctgtat ctggctgact   120540

tcacatgaaa ggaggtggca cttagaccag accttacagt atggagaaaa tttcactggg   120600

cagatgtggt acagaaggaa atctcaggca gaggaacaag cattcatatt gttcacctga   120660

ttcactcatt cattcatcta tccacccatt catctattca gtgttcagtt tacaaagtca   120720

ttatctttgg agatacttaa atatgcttat tattatgaaa tgtagtcatt ttgttgacct   120780

gataaaaagt tgtttcaata tttgcagttc ccaaattaaa tatttaatgt ccttttacta   120840

tgtggtggtt ttaattacac tgttatcaag actttctctc tttagatttt taatcaaagt   120900

tttagattta ccttctgctt attactacac tttagaaaat ataataatct tttaaaaatg   120960

catttgactt tgaaagattt agggattagt tacagttatg ctgtttcgta aaattggcat   121020

ttgattctat attttatgca tagatttttt ttaaaagcac tcttctgtag aattgcactt   121080

agaccatttg tttttttcag gttgtttcca aagaatttga aaaatctttc catcttcatt   121140

ggatttgttt acgtgcctaa aaacaatgaa atatttgtct gacatattca aatcaatgtg   121200

tcttattctt tatattttga taaatttgga aacttcactt ttttgcaatg ctgtttaaaa   121260

tgtcaaaatt aattaaataa aaataagtca atcaagaaat gctaatttta gaatatgctt   121320

tttaaagctg catactctta ctgccacctc accccctata ctgagaatca cttatattta   121380

aatgttgctt gcatttaagg aaaaatagaa tgcaaaacat tgcattagca cattatagta   121440

tttaaattca atttttaaat agtagagtag aattatgtaa ctgtttaatt gattgttttt   121500

aagtctctgt tgaatgacat ttaatcttag tactgtgatt caaatatatt gcttaacgtt   121560

gagtatatag catgtacttt caaatatgta actaatttct acttacaggt atatgacttt   121620

aaacatttta aaacacagtt gactaaactc tttcatcatg ctgcatttct aaaattcagt   121680

acctaacctt cttctcacag gggtaatatc aaactggatc agtcaaggat gcagctctgt   121740

gcttttaacc aggcagagac atatgtcacc acttttacac aggttaccta aaaaaatcat   121800

acatacgata ttttttcaat gtcttgcatg ctgttcagct acaaaacctt tctgcctgac   121860

ccactgcaag aaagtagaaa catatacagt tgttcaatag ataaagtgac atcacagcat   121920

gtcaccaggg caatttgatt atttttttgt gattctcttg atgacttctt gatgtaacct   121980

tcatgtgctt aagtgatttc aagtgcatga tctgtagatt tttattgaat tgattataaa   122040

agtaaaatgc agaatgtaac agtagccatt gaagctacat ttaatttgaa aacctctatc   122100

aacttccctt cctgatttaa tctacataaa aatatggaga gatgtatatc acattaaatt   122160

gtcacattta aattaagtag atcaaaactc taaaaaattg tggaagaagt gtttctggca   122220

taaatataaa atctcagagc aggaaaagat cattgtaatt ctagctttgt atttaataat   122280

tctggttatg tatttatgga taagcaaatt gagactcatg ctttcttagt acacatctag   122340

aaagttgggg tcaaagccaa agtaccctgc ttctagtata aactttgaat acattttgaa   122400

atggttttat gcactgttag ttatgggact ttattttttt aaatcaactc agtaattaac   122460

atttgatttt atttgctcct atataaaatg catcagttaa aagttgatag gccttgccta   122520

tgaatgaata agtgataagt gttcaaaatg tttaatttta ttccagaagt aatattactc   122580

attgataaga ataagtttct gattatatac ataatcagat cagtctctag aaactaagag   122640

gtttagatag agcatattat aaatcctatc tatcaataac acatagaaca cttttactga   122700

aattagatac agattaatat gtattgcctt attgaatatt tctaaaatgt attaaaatac   122760

atactaagat atattttaat tttagcatac tttgttgaat gactgaactt taatagttct   122820

aggatggggg caggaatctc tgccaataag aatcttgact cctttttata atctagttca   122880

tattttgaat ttctctgtca ttgttgagat gtttgtatta ttgttatcta ttgtgcaatg   122940

atgaaagcaa aactttatcc tgaaattgac acaccttaga gataatattg ctaacagttt   123000

caaatgaaaa attagttatt ttagtgttcc agtttatttg aagataattt taaaggtggc   123060

ctaagtaaaa gatatatttt tctatttcaa atttggtggg gatttagagg caatattctc   123120

atagaaaact attttattcc agaatatggt gaattttctt caactagagc ctaaataagg   123180

atgcatatac acccaatatt atctatatag gtatagataa aacatataat ttttgagaaa   123240

gctatttcta gaaatatata tacatgcata gacatataaa catatgcata tatatgtttt   123300

gaattcataa attcttatta cttttttacc aagctgttag aaaagatgag gtacatgtta   123360

atgaatggtc atcctcttaa gaaaaaaact gaatattcag ttaagaatga cttgaaatat   123420

ggcactttag caaaagctgc ctacataaag gatatagtta ttttatccat gtaaaatttc   123480

tatttatatt ttcaatatta gaaatccaca tgtttaaaaa gctagtaatt attccattca   123540

ttaaaattca cttttccttg ccctccttca ttgtgggtag tattagtagt taacagaaat   123600

gattcagata tctaggtagc ttactttgtg tttgtcattc ttgtttgttt caaaattata   123660

gataatattt acgaagcttg agtctgcgta tctacacttt gcctttatgt ttgctaaggt   123720

tccaatcctt ctttacctac ttgttgcatt tttttaagct ggcataaata gcaaaattgt   123780

ttaaatgttt gcttctaaag actttaagac actctgactt gacccactgt attccagctg   123840

ctttctctgc aaacagtgta gcagttctgt gacagagcac agagagagcc cttgaatatc   123900

aatggccact ttacactcct agctctttgc ttctcttctt ttcattagaa agatgcttca   123960

agatgatact ataggacctg gctgagaaat ctgtagccag tctagccttc ttacatggcc   124020

aactgttgtt gcttttatat gatttcttta tattcatatc ttatcattta gtcacgtaag   124080

ttttcatgtt attggataga aagtgcccta ggtagaagat tctgagaaaa agaagaggtc   124140

tccgtgaaat cactggtttt attctgaatt tctctggtgg tggctgagat ttgacctcat   124200

tatttcacca acagaatact atatatcatg ttgaccttgt gatggaactg tgtgtttcac   124260

gctgaataag tagctattcc tcccagagcc tacacaatat ttctctgcta gcaatagaca   124320

aagaaaaata ggaaaggaaa aaaaattggt tttcttgccc tttttttaaa aaaagagcta   124380

aagttttagt tgcccataat tagaatgtga gcccagaatt tattgcaact agttaataaa   124440

ctgacaattt tctgctaaat tagtggaagt aacattaaaa cttagacaac agaagaaaat   124500

acagttgagt tttccactga tcaataatat ctggagtatt ttttaattat ttccattttt   124560

ttcctgaaat tcctgagctt cagtgatttt ttaacttgag gcattacctt ttaaaaagaa   124620

tcttgagaaa tttcatatca aaaaaaaaag attgtagaga cctcaagggg cccagaaatc   124680

taaatcatgt taagaaatgt gattacactc aagatgaaaa gcactaatag taatatcaat   124740

aatattaatg acctccaatt ttaaaaactc tataagagga taatgttcac atttctccag   124800

aaggaaaaaa ataaaggccc tgaatgattg caagagagaa gaaaggttat ttttgttcta   124860

caccagaaga gagtatttaa acatctagtt gtcctgtaac ataatgggaa acttggaaaa   124920

tattggactc ttatgccaca tagtaactat gtgtggattt cttctcaaag gatcctttga   124980

tcctttaatt gaaatttact attttactcc ttaatgattc aagaacacaa ttatagatat   125040

tgaccgtaaa actacacaat taaattaaaa gatggataat agtaacttga aactaatttt   125100

aaaatgtctt tcttgcttat taacagataa tggagcttag tttaccactg tctgccataa   125160

tttttcttct cttttatacc catctcctcc ttttgatttg cttctctcaa ctttcttact   125220

gtcttttgtg agtattttaa ggctcaggtg aaataaccat tctaggctct gctccttaaa   125280

gaatatcttt ttttttgttg tgtgaagcaa acagtttata gtatgtactt gaaatgtaac   125340

atttttcagt tcttttcagc atcaatcatt ctctttgagt aaggtttttg ttgagttctg   125400

tgttttgtac agtgctgctg tgtttgatag tttcttcttt tgagcgttag attatcaagt   125460

cattagacac tcctacctca cacctcttgg aacaataaat aactagcatt aaccatcatc   125520

catgatagca tgaaataggc ttacatcgtt aatgtttatc ttaggaaatg ccagtgataa   125580

atttgtaagt gaacaactta ggacatgttc taatatgata catatattta acacaatttc   125640

tactcaagca gtatagtaga aaacacagct tcaaggcaat caaagggaaa accatgaaga   125700

ataataaagc ttttaatttg gacatatttt cagtaattga aaaggagcat cttaaatagc   125760

tacataagtt tacaatcaag ataaggattg tttcacagct atagtgttgt atggatgcac   125820

actgaaaaat atggaaagat atgtctctct ctctctctct ctctctctcc tctctctctt   125880

tttctctctc tcgattacct caagggggtt gaatcaagga gatagtggag ggaactttta   125940

ttttgcactg taaatactat tatacattta aaatgtttga gtcaactata tcactttcat   126000

atttttaaaa cacttttaga aggcacagtc aatatcatat tattcaataa aaaggcagga   126060

atgctaatta tggtacactt ctgattccta atactagtga gtccaccttc ttgatcctat   126120

gcttatattt atatttactt tatttataac tagactgcca atgatgaaaa aaattgatac   126180

ttccctttta ttagaaatca aatccatgtg aaaattacag aaggtcctat ttataatagc   126240

aaaagaaatt tctttcatac taaagcattt atttcacttc tctaatatag tcattctttc   126300

atttccaaaa ttacatggaa aactaaacaa cagatgattg agtttaaaga aatgaagata   126360

atatagaaat taatcatata aaataataca aataattgat atgatcttcc ttgtatagta   126420

aaaaacatat attcaaagta cttaaatatg gtgatgccta ctgtgagaat tcaatatatt   126480

tcaccgcagg aaaaaaaaac tttattatat atatcagcct ttctatataa aggtattctc   126540

ttagaaatct gctaaagaag cttatactgt agcaagtata gatttcaaag gctgaattga   126600

ctagaactgt ctatattgct aaagcatgct tataaacatt taattttata tacagtatgg   126660

aaatagttac tgtttgaata cttaatgcat tcccaagaaa acattgaatg tctaagaatc   126720

tattagccat aataatttgt ctgtaaatac aaattaatta ataatagttc atgttaaata   126780

ttttgataat ttctgtccca ttgaacaata atattgaata actttatgat gtaaaattct   126840

gtgccaagct gaattcaatt gaccattaaa aaaacataaa acctgcatat gaaaaaaagt   126900

ttcaacaaca agatacacta tataaaatca cgtgaatttt tacttgctca taatctaatt   126960

tggcataaat ctttgttaat gctctcttaa acagtgagaa aaccaattat tgatgtttga   127020

agatgctttc atgaatttag ctaaagtcag aattctgcaa ataagaatca ttttatttaa   127080

aagttgttac cagctcagag aaaaaccatt ataactattt cctattgtta atattgtgtc   127140

taatagcagg ggggtgcttt gtattctttc tatcagcaat tcctctcact gctttacctc   127200

aaaacccagg ccaataattc ttttttcaga aatgaagggc ctggtcttaa cttcacagaa   127260

taatagggcc ttgtctttca cttctctggt gatagttcac gtgcagccga gaggtcagga   127320

attgaagcca ttaaaactgt agtcttctaa atatggtact ttggattttg tggcaattgg   127380

cacaaaatac atattagtaa ttataagttt atccaacatc gtttcctgga ttaatctgta   127440

ttttaaaact tatatatttt aaaactcatt ctatagttta tactttaaag cctattctat   127500

agttttatag aatattcagt tataattaat ttctattatc ttattttaaa ttaaactaat   127560

ttagatgaat tcaatcagtt taaataacat gtttttgagt gaaattttgt actgatactt   127620

tcataactga aactgttatc aaactcctgg acctggtggg aataatgcct ctaggccaac   127680

atagattgga ggagttctct taataggttg ttcataatta tttactccag ttataagaaa   127740

gacattgtct gcttacatca ttccttatgt acaatacttt atccatgcca tttttatgat   127800

gttgtatact aggtgataat aatagcattg agaatttaat gtggtaccca tcaagaatac   127860

ttctagcttc caagtcaatc tctaaaagtc aaacctttag attgggctat catattaata   127920

caaattcata gattgagaat caatttatct gaaataagta ttttattatt tttagcactt   127980

gcacttgctt gaactactct aaaaaagata aagttgtaac ttaataagag aattgtgttg   128040

tagtaactag tagctttcaa tattcacatg tcatttagca aatgagaatg aaaaattaac   128100

tcttccattg atatgctgct ttactccttt ataaaacaat atttgggaaa tttgacagag   128160

ttttgctaca gttgctgtat gtattttttg taaagatttc ttcgtgtgtg tgtgtgtatg   128220

tgtaaacatc atggttactc ataaagctct gggtgagaaa aacctatttg cgttatgatc   128280

acttatatga tcataatgac aatgaattca ttattccatg tgtaagtctg ccatgtttaa   128340

ttttcttcga tctttgtttc agagtttgca tgtggtgctt actttagtag ccactttctt   128400

gacattataa ataatactgt ttgatctttt ctactatata ctaaaatgtt atatacaaaa   128460

tgggtggtgt tggtatggtc attggcattt tgatttcaaa accgtatttg attttgtggt   128520

cttgatcaaa gaacttctat ctatatcatc ctgctacata tatttaaatt caagagataa   128580

taaaaaatac atttggactt tatcttgcac ttatcttttt aaaaaatttt aactatcaat   128640

aagttttttg ccaactattt gatctgagct ttcaatgatc aggcattagt aatttgacac   128700

ttgtattata ttgcaaatag ggtataggtt gtcctcaaat aatgattgtc agtgtccata   128760

aatttatatt aaaaatttaa aaaataagat gtggtcaata ctttccaaaa gtgatagtta   128820

acatcaatat attaccttat ctaattttgg ccacgtactt gttagtataa taaacataat   128880

aaagtttatt attttacagg atggtgtaga tagaaagatc aagtatagat acatttaagg   128940

ttacttgacc tcaatatgtg tttatacatt ttttatggcc atcatactat taatcttttt   129000

tcataatact ttgcatgagt ctgattatta aataaggctt aaatatcata tttgaatgaa   129060

ctctaaatga actacctggt ggggtggtga attcctttct agagattaaa ccggtcaagc   129120

tcctcagagt gcagcacagt tgataaccct ttgcctggag aaggagaaga agcagaggct   129180

gaacctatga attccgatga gccagaggcc tgtttcacag atggtaagac aaaaattgag   129240

accttggtta gcattcctta attagtgttc tggggtttgt cttaacgcct aatacttacc   129300

agaggttgtc ggtaagtcag aagactccat tccatgctga ttcagctata gctgtatgat   129360

gattaagggc aagtcactag agctctctaa gcttgagttt ccacatctat ggcacttgac   129420

taacagtaat ttcctatcac tgtatgttag actgtaagca tgctactact tcttatttta   129480

gagccttaat tcgtattccc agatcaatgg aaccaccaga atacaagtta atgaaagagt   129540

ctgtactctg gtccttttaa tcaaaaatgg aatctactca ctaactctca gaaaactgtt   129600

tgatactgtt gactacagtc tctctcaaaa ttcttccttt ccttagtttc agaggccata   129660

gtctaccttt ggtcttttat ttgtcttaga gttctgagtt cctctctcta tttctttaat   129720

gagtattttt tctgcacatc ctgtaaataa tgatttctcc ccacatgttc aatcttcagt   129780

tatcttttct tattctgaag ctctgaggtg tttcatgcat gcctgtggct tgaaaagcca   129840

tttctgtgct attgactctt aacatcaatg tctttacctc taacctcact cttgagtccc   129900

agatctgctt acaattcccc attggtcatc accatctgtt gtttgtaaaa cattccaagt   129960

ttaataagtt tttttttttt tgaaaagcaa aaacaaaaac aaaactttag tatggtttac   130020

agcttcctcc agtctttatt agtaacttca tgatctacct taccctcaag ctaaagactt   130080

tgagagaccc ttaaagtttt ccttgctagt cacaagttca tcaggaactc tggagatagg   130140

gcccaagccc ttaagaggat ttgcatgcac actaaaatgt gagaatcctt ggcctctagg   130200

gtaaagtctg aagtccttaa cttgacatgt aaagttcttt acatttggcc ttagtctctt   130260

gttttgtaac agtacctcct tctactcctg tatgctttct gatatgctga atttcttact   130320

acttctggaa tttgtcaggg ataatgcagt attgtctgaa caagtattgt atcatctagg   130380

taaaaataca agcccagagt agggctgcaa tgtaatacag taatacaaag ttcaaacttt   130440

ggagcctgat aaacatatgt tctaatttgc cgacttatct gcctgtgaga acttgtgcac   130500

aatttaaaat cttgttcttc agatatctca tctgtaaaat ggggatatca gcatccacat   130560

cacagcgatg ctaagaggat caaataagat aatgattata aacttactag cacagtgcct   130620

atcttccttc ttctactttt cttattcttc aaggattctg ttaacaatct tatacagaag   130680

ttatgatagc acagatgcta atgacttatc tagtcatggg cttaccctca gcattagtat   130740

tttttgaaaa atcatcgact tgctttcagt gtccaagatt ttctcaactg gtttcttata   130800

acattcatgg gttaagcaaa atgattggaa aataaagaca tcagcaaact acaaagagtg   130860

catggatttt ctttaaatac acaccaaata tcattttatg taagaagcaa aggtgtacga   130920

catccagtca atataaattt tgtgcttgct gaaattagtg ctataagcaa atgcacagtt   130980

tcctttaaaa gtgtccatgt tacagagatt taagaatttc atcaacatgt atggcctgct   131040

cctcaagaaa tttattagca gtatatagac ttaaatttgt attgatgcta ccaagatttt   131100

ccctattcat tttatgaatg atcatgactt aaaattctag gataactaga aagaagttgg   131160

gcttatcaat caacttaaag tttcaaacca aaaaatgact tcaaaaaact taaactctta   131220

cagaaagtat taatactatg ctatttcaga ctgtaggtgc tgttataata agatataata   131280

caaagttttt ttaatcctat aaacatcaat gaaaatactt ttgtgaatac tctgagatta   131340

ttcattgctt ccaaactgag gccagtatag aagaaatatt atggaaacac attttccaat   131400

gaacctgggc ttggaccatt gaaatttact gagggagcat atatctctga gtcacatccc   131460

ttttatgtgc tccagcagag acttcataca gtctctggat ctgtagccta ataaattcag   131520

tgaagcagcc aatttgctta gcctttcaac cgtgtattca cataatcatt ctttattcca   131580

gtaaacaaat aattattaaa tacctgtgtg ccaggtccag ttccaggcac tggagggaga   131640

tggagctgtg aacaaaacaa taccccttgc tgaagaaaca tatcaagatg tagcaggtca   131700

gataagtgaa aagtgctatg gagaaggtat atggaaaaga ggaataccaa gagtgagggg   131760

gaagaactta ctagcacata aatatgctat caatgaatga ttggtcagag aaagcctgcc   131820

tataaaggtg gcgtttcttc cgtgatgtaa agaaaattga agggggccgt gcaaatatat   131880

ggagggaaag tattttaggc agagtaatga aggcacatgc cccaaggtga ggatatgcat   131940

aacatttggg aaaaaccaag aggccaaaat agatggagaa taatgaaaga tgggaagagg   132000

attaaaagtt aaggtcagag gctgggtgaa gtggctcaca cctataattc cagtactttg   132060

ggaggccgag gtgggcgatc acttgaggcc aggagttcaa gaccagcctg gccaacgtag   132120

cgaaacccca tttttactga aaatgaaaaa aaaattaatt gatcttggtg atacatgcct   132180

ataatcccag ctacttgtga ggctgaggca cgagaattac ttgaatccag gaggcagagg   132240

ttgcagtgag ccaagattgt gccactgcac tccagcctgg acgacagagg aagactctgt   132300

ctccaacaaa caaacaaata aaacaaatga cattattttt aaaaagtgta gatcagagat   132360

gtagtagagg ccagattata agacatttga agaacattat aaggatgtga ttttaaaatc   132420

tcacaatgtg caatcttaag agtggaaggg cgaatagcaa tggcagaagc tggaagattt   132480

cttggagttt ctgcataaat ccaggtgaga ggtgatggga gcttagacta gtatggtaga   132540

gttttgtata gtgagggtgt gacatgctga gtatattttg aagttagagc tgaagggatt   132600

tgttgatgga ttgaacattg ggtgcttaaa aactggaaat gcatagtttc cacatgaaga   132660

ctgagaagca tgggcttgtc agaatgaaga atcatgaaca tgtttactta caagttggta   132720

attggtctac aagagctggg ctagaatcaa tgccagttca gagcaatgtt tcacctccag   132780

agatctctgc tacctgaaag gtaacagaaa aaattaaatg aagtatgaaa aagaattaaa   132840

tccaagtagc atgtttttac tgaagataaa tgttaaaacg attttgttgt tcatagtctc   132900

acatttgttg attcatttca gcttcataat tatcacttta ctaatgtatt tcattgattg   132960

catctggttc ctcttattca ccttttctct ccctcttatg caaggttgtt ccttagctct   133020

gtgtctatta ctttgtattt gaagacttca gactgcttcc gtatatcttg ccctgttctt   133080

tactatcctt agttctacat gacttggcaa cctatataat tatgaacatg acatgactct   133140

ttgggtctat gtggttttat attgtgctgc ttttagatta tcaaattagt aaattacata   133200

atcaggatta gagttagcga aaaataacct ttttcacaag gtcaagagat cgagaccatc   133260

ctggctaaca tggtgaaatc ccgtttctac taaaaataca aaaattagct gagcctggtg   133320

gtgagcgcct gtagtcccag ctactcaaga ggctgaggca ggagaatcgc ttgaacccag   133380

gaggcagagg ttgcagtgag ctgagatcct gctactgcac tccagcctgg caacaaagtg   133440

agactctgtc tcaaaaaata ataatggtaa taatagtaat gtatttttct gttaacttgg   133500

taggagaagc caaatcatct tcctttcaaa atgttttgta ttcaccccct tcctataaaa   133560

taactaataa ttaattctaa ctttagtaac acaataacca actcctttgt gacttttatt   133620

ttttctttct tttggaaaga taatgttaac aaatatttgt tttagttata tttgatgtta   133680

agaaatggtg aaaaaagctt gttttcataa tcaattttta aattaattat attgatcatg   133740

ctgttatggt ttttaatgaa tagtctgtct tttgaagtgg tcagtggttt cttttttctt   133800

tcctttcctt tttttttttt tttttttttt gagagctttg gtttaacatg atgaaactca   133860

gcatagactt tatgtaatgc accatgagag cacattagtg aaaccaccca aaagaaatag   133920

catttactca ctgggaccca ttaaaatgtt tgagagattc tctgttatgt ttacattcaa   133980

ttaatagtcc ttttaaagag aaggtatgat aacattgcta accagcttag ttggaaatct   134040

cttgggatat acctttgcac aaaaaccaga caggcgctcc atcactcttg cctcaaaata   134100

agagaaagaa actctctgag gtgtaataaa ccctgagggc aatatttatg aaacttcatt   134160

tcagattgaa agtttactaa cttttctaat taggattttt agtgttttta tttcctcaat   134220

cataagaata atgtttccct tcaattttaa gattgacaaa agtaaatccc agagagcaaa   134280

atcttcttaa ccaaagggat aattttctta tccaataatt tgcccctgag aaagataaat   134340

tctttcttat atgtgatcat tgtttttaag tttaagacaa attctaaagc actaagttaa   134400

tattaaaaaa ttcatctcat ttttttcgct ctctctggta tttttatttt ccctgaaaaa   134460

gattaactta gagttaattt ttgaccctac ccttttactc tgtttttata tcattttatc   134520

gaatgttctc tcttaactaa atgcatgtag ataataatta tttaagtata ggatgataca   134580

taatttcaga tctgagatca tgttcactgt aattaacatt gtataaatga agctatgtgt   134640

agattttcca ttcacctttt tttttctttt tcatccaatg tttatgtaaa gtatagaatt   134700

cacagagatg taacctttca aattatgact aactgcttag aagattatat aactcttttt   134760

ggggaatcaa gtcttttaaa aatcaactat aaatgaccta ttaagccaag tagaggacta   134820

tgatgagtac tataagcaca aagagcaagc attacagact cagtttgagt cttctgggaa   134880

cttagaaact tccagagaga aaaaacagga acacataaaa tatacatgat aacaaaaaca   134940

ccagagacat agggggagag ggaaacacct tgtttgctgt atttctatag agctggaaat   135000

taaagtgcta gaaaataacc ttatatcaac tggatcaatg cactaattag acttcagaaa   135060

catgaaaaga ttcattacaa aacattttct accaggtgca tcttgtcaag aggattctag   135120

ttttgttgtt ttagaacata caacttatga ttatctgaag ttgttacttg aaaactcaat   135180

acttgttaat gaattatatt gttttacaga aaaggagatc aatcttttag aaatatctaa   135240

aattcaaact tctgaaacag gtatcaaaaa agtgctgccc attcttactt tcccacctcc   135300

tgccttcatc taaaatgagg tttttcatct aaaattttat gaggaagaat tcactgtagt   135360

tactttttaa agagtctctc ttttcttcag agtaattcta gttgctttaa taaactttaa   135420

attgattaaa atttttcaat gtttcaatca ttctctttct gggcctctta tgttcatagc   135480

tctgtttatc acttcttata aaacttttta ctctttggtt tctcttttac tgcaccctct   135540

tggtccttct tgttcatctc tcatttcatc tacttcaaag ttttctcctc tacctgtcct   135600

agtgatgtgt aggtaaatat ttttataaac tggttctcca aggaaaataa aaaatgtgta   135660

cttatatcat ttactataaa ttttactgat attaggatat atgacacaca atttacaaat   135720

aataaaatat tacaactttt tattgaacat tctgtatatc aaattgtttc tcaaagaatg   135780

ctttttttga actttgccaa acttttgcat gtataggcaa cctatttttg cagctaataa   135840

acaagtatag ttttagcatg aagactgctt gatatttatg ttagtcagtg aaataaaaaa   135900

gaaatgaaga agctatatgt cagaacttta ctcattcatc agtgatgtaa gcaattattt   135960

gcaaatcaaa aaacagaatt tcaataatga aaggatattt tttaattttt gtgctattca   136020

gagtaatggc tacaaacaca atacaccttg actgtttatc tgttttattg gcatttcctc   136080

catcaccttc ttaattctac tctagaaaat caagaagctc tcatttgtag tgcttggaga   136140

tttttgtaat gtaaagattc ccaccatcac tgatttcaaa ctactgatgt gaaattgcta   136200

aatgcagagt taagaagaga ttcacagtag ctcaacagtg tgacatactt ccaccatcca   136260

gatagaatag gccagataga atagaccagc atccagaaag aagagttgca cagtagccca   136320

atagtatagc atattactac tgtccagaga gaataatcca gagagaatag accaccgtcc   136380

agaaagaaga gatgcacaat agcccgacag tatgccatac ttctgctatt caaacggaat   136440

agacaaataa aatacagtaa aataattagg aagtgatatg tcttagtatt tattaccttt   136500

ccttaaggta agttatagaa ttctaagttt atatagtcaa atatttaata atggctgctt   136560

ttaacaacag acaagcagga atttctgaca gtttaacaac aagaattggt atggtctgct   136620

ttcagcacac cattgaattc tctcccttaa tattgttgtt tcagaatgtt tcggagttgg   136680

ccctttttct gctcacccta aatactcttt ttgtgtgacc tcaaaaactg ttctgacttc   136740

agcagataca tgtatgctaa ttattactaa gaattctttt ctagacaggt ttttcccgtt   136800

tcaggttccc acccccattt ttaaaatcta taggatatct gtatttaaac aattcacagg   136860

catctcaaaa tcattacctg ccgagtcagc tcctcctcct gtggttttca attcactgct   136920

aacatccacc tggtagtcct gggatccttc ctttctctta catttgatat ccaatcaatc   136980

accaaatcct gctgatttta tctgccaaat atgtcttgaa tctgttacaa ctctagttcc   137040

taactaatct ttccctccag acaggatact ggaccagaat ccaaatggtt ttctgggtat   137100

gaaactttct tcacccctac tcctctctat tcacccttcc aacttatcct ccatgtaccg   137160

tggagacatc tatttacatt gcaatttgcg tatctcgttc cctgcttata accctttact   137220

tactcctcaa cctcaatagg atataagcca aactccttaa ggtaaaggcc aatgctttcc   137280

ataatctgac caatttttct aagctcacct ctcacccttg cctcttgtgt acattctgct   137340

tgcatcacaa ttctaaactg gtttaaattt ctatgcataa caatttttgc tgcctggaat   137400

tccacccaaa ctctttttta ctgatatttt gattcaaccc aggctccatc tcttctagga   137460

agcctctact gatctctctt tctcaagaaa taagccaggt gagattgatt tcttccatgc   137520

tatcaaaatg aaccctgact atctgtcact ttagttgcca tatctagtta tagtcattta   137580

tttctgtttt tatctaccta accaaaacct aacataaatt cactgaggaa aggaaatcat   137640

gtacagaggt gaatacataa aagatacgta acaagggttt gatggacaaa agaatgcgtt   137700

aatgaatgaa taaacctaac catttttaag tacaattttc aattttttgt agcagtatat   137760

tttgtacata aaaatttaaa gtcacatttg tttttaactt agaatacttg aaacagtttc   137820

atctggatct tctaatcaag atgagtttct tttgaactta atttcaggag tttccactaa   137880

ttttctcaat attgtttaga aaggtgtatt tcagagggtt tttaccatag aggagtggaa   137940

gtatctaaaa ttatagacta gaaaaattta tctgtcagaa aagaagaccc taaaattcat   138000

gtcgtcttca gattttagtt cattcattca ttcacacata aaatgaaagt ggtttaaaga   138060

ctgtggagga gactgaagag aaattgggga ttacagaaga caagaataca ttgtaagcta   138120

aaactaacta acaactattt agaaaacatc atgcaaagtt agaagatgaa ggaaggcagc   138180

atccaaatta aatctatctg aaattgcaag tataggtgtt gaaattattt ggttgaggga   138240

gtatcacaga aagcagtttg cattaaataa tgtattaaaa attttattta ttctgaatat   138300

caagatttaa catgcatgtc tttcttgtca ggttgtgtat ggaggttctc atgctgccaa   138360

gttaacatag agtcagggaa aggaaaaatc tggtggaaca tcaggaaaac ctgctacaag   138420

attgttgaac acagttggtt tgaaagcttc attgtcctca tgatcctgct cagcagtggt   138480

gccctggtaa atgatctgac acctaagtca atatattgat taagtcaata ttctttaaaa   138540

tgagctaaaa gataaaaata tcatggcaag ttgttttacc tagaattaat ccctatgatt   138600

agtgccaatg acaaaatttt acttgagctc agtaaatagt tactgagcac tcctacatgc   138660

caggcattat ccttgctgcc ctgaatgctg ttgtccaaag gaccacccag atggctataa   138720

tagaaaagag aattttactg gcaatatcag tttgcaaaac agggagagag tctgtggcat   138780

aaactgaaag cactttccct gtagaacaaa gagagaaggt tagaggtttt attaaaatgg   138840

gaaaatgtta tatattgctc tttgagaaag ttcattggcc ctagtaagga tctggggaac   138900

tggtaagctc caactggcga gcaacagtcg ttggcacaat tagtcctaga gtgtaacagg   138960

tttcctcaga agctatagat aaaactaatt tcaagttaca acaagcagct tcaacagtca   139020

gtcttgcaga gaattataat tcttggagta atgttttgta ccctgagagc ttttccccct   139080

gccttcttga ctcttagttg actgttagtt gagtaggaca agaactaccc aatttgtatg   139140

atcaactttc acaatgcaaa gataaataag atccaggtac tgtttattct taaggagctc   139200

agagcaatgg agaagagaag aatacaaatg agtaactgta gagcttggat gtgtttgtaa   139260

gcaaagtgta aatgtgacaa agttctgtag caaggagaac aactgcttgc aatttcagaa   139320

acgtaaatgg tgcttttcag ggtctagaaa gacgaacagg aattttctag ttaggcaagg   139380

caggctgagg ggaacaagta tacaatcgta aggaggcata aaacagcatc agatattcag   139440

gaaattaaaa actgctgaac tgcaagtgtg gtgggaagaa gaacaagtac aggtggccag   139500

agatactatg agaaagcaag gtcagcttgt gaagcatctt gtgtgttata aaaagggaaa   139560

acagatggta gttttaggat aaaagtagga caagtttctc attcttgtac acatacaagc   139620

agcttccatg agagttgaaa gagatctagt agaattacaa gctacctgaa cctttttctt   139680

aattgtcatt tttcctgctg acgctgacag agatgagcca ttagaagcca ttaggagccc   139740

agatctagct agatatacca ctggaagttt cattatacta aaaatagaat actcaagaac   139800

tttgtaactt gcctcataga cagtcttcat gagtttggac tttgatttta ctgtacttat   139860

atgctaatag gttgatctga tactgtttca tggatgctgg cagaagatat gaggtgcttg   139920

ggtcagagat aaaggacttt gttacttatg tgtggaaagt agcatgagtt tcaacatgtt   139980

tctgttggtt ccccctttac ccaggtctca tgggggcatt atatgagcct gaatgagtgt   140040

gtacacatat agtggattga tgtcacagct gaggaacact gagcttaggg aatgcatcct   140100

tttataccaa gcaacataag caaccctgct ctttgtccca gagaccctac ctcatgtctc   140160

aaggttgctc actgcaaaca caaccctgag gaatgtccta ggtaaggagc aggcagagcc   140220

tggcattctt ggcacactcc ccaacaacct gcagggaccc actgtggctt tcctttccta   140280

tcaagtctca actctcagaa acagaaaatg tgatcagaaa agctctattt tccttacctg   140340

gagtcatcca agtagaaatc atgatagtgt ctaccatgca atgtattcct agtaactaag   140400

gaggtttatc ccatgctgac tcacatatgt gactgagaat ttcagagagg agattacaaa   140460

aaaattaaag tttggagtaa ttccttgttc aaaatgtcta aaacagagga agacatttgg   140520

ggagggcatt ctcaaaagtg tattttaaat aaatcatatg aggaagaaaa gggaaagata   140580

tttcaagaag ctggtgtttg tacttagaca ggttgccaat taaactagat tttttaaaag   140640

tatagcaaac ccccatgaca cgtgtttacc tatgtaacaa accttcacat gtaccctcaa   140700

acctaaaata aaagttaaaa agaagtaata gctctcattt agcttatact tattgtgttt   140760

cagaatcttc ttttagattt tctcatttaa ttttcaaaca accctgtgag attatgatat   140820

tttgcttatt ttaccaatga tgaagctggg tacagtttta aaagttgctt aatgtcccaa   140880

agctagtaaa tgacagagct atcactgaat tgacatctaa aatcaaagtc accatatctt   140940

ttcactgtgt tgtggctcct cagaaagaag agtatacaca aaacagaaat aaatgagtgg   141000

taactgaatt tagtaacagt aaagcgttaa gtcctaaatc agatagagct cacataaggt   141060

cattcttgcc tccttgctcc tacatccaca aaattggttc tggaagctag aacccctgtg   141120

ggctgaattc taattcctgc tctgggacca gtcagagaga ggttctcatc atcaagactt   141180

cctgcggctc tgctctgacc ctgtacacca gttctagaaa caggcttcgt tttccttgtg   141240

actaagcccc ttccttgtct ttgtatttca aggactgagt cattgccata gtttcggttt   141300

agatggcttg cctgattcct ccagaatttg ggggtggagt ggaggggagg aaaatcctga   141360

gggctagaag cctccctctg cacttcaatt ccattgaatt tcagaacctc tgccaactgc   141420

tgggaccttc tttttgcatc ttagtaggtc cattcagtct ttctgcccca acttgtctct   141480

tttcttcaat attgatacca acagtttccc aaaactgcta aggataattt tagagtattg   141540

aaagcagaac gtagaataag aagaatctga atggcacaag ttcatgactg tagacaggta   141600

ataaatataa tattaaccac gaaggataca ggtctttgac tttcatttta tccaacaggg   141660

ttaatagtgt ttcgatctga aagagaaagt tctaacactt tagacctgtt gagatcagca   141720

atcattttca gtgtctcaat gagccttttt tttttttttt tttttgagac agagtcttgc   141780

tctgttgccc aggctggagt gcagtggcgt gatcttggct cactgcaaca atgagcccaa   141840

tttttcagtc ctttcaaatt ctttgtcaag ggacatgtgg ctgaagtcta aagtcaaagt   141900

caccctgtcc tttcactgtg ttgtggctcc tcagacagaa gagcatacac aaaataggag   141960

taaatgagtg ataaccaaaa ttagtaacag taaagcgtaa gccctacatt agatagagct   142020

cacctaatgt tgtcacataa tgttgtgtgt cacttactaa aatttcttgg aaagcatagg   142080

aagcaccgca ttaatggaga gaatagaaca gtgattttta gagctgaagc tttgaaggat   142140

aatatatgga tgaatagtca aaggaaaaag caccctctgt gttctatagg cctattaagc   142200

tactgcagtc attcatttag caaatctttc ctttcctgct gctgttatta acatggtact   142260

aggcactggg atgcacaagc atttgagagc tgaaagacag gctccacatc ctactggtgg   142320

ggaaaaaggg gagtgtagga tgtgaaaagt ttataacagt ggctggccat gggatcatgt   142380

cttaaattgc taggacttat ccaattttaa tggagaaaga ggaggaatca gatggaggtg   142440

gaaatgatca ggtgtcagag atcatgagtc tttttgtgga ttataagtaa tttcattctt   142500

ttgcactttc tcttgacctc tgaagaccag cagcagcact ggtgagaagg ctagaactaa   142560

ctgttatatg ataactgtaa accagaaaaa atgtcagctg gcccatgtca atattatgtt   142620

tcagcagtct tagcattaga attgtatttt tcctgttttt tttaaatgaa tcatgaagct   142680

taagttgtgc atgattgaaa cttgaatatt atttccacag gcttttgaag atatttatat   142740

tgaaaggaaa aagaccatta agattatcct ggagtatgca gacaagatct tcacttacat   142800

cttcattctg gaaatgcttc taaaatggat agcatatggt tataaaacat atttcaccaa   142860

tgcctggtgt tggctggatt tcctaattgt tgatgtaggt acttttgagt acattttaaa   142920

agaggattta ttcttactgt gtgttgtgaa aaaaccttca ccactattgc atattatcat   142980

attttaattt tgttaagctt catatatttt caggctatag gtttattctt ttagaaatat   143040

taacacagcc agtggaaata tatctgtgag gaatattaga acagaaatcg ttcaacaaat   143100

gtaaattatt tctgtgacat tgtaacattt ataattgagt tttttatgtt ttctgcaaag   143160

gagatgtgat tttttaaaaa atatgatttg aatgtcattc ttgttaagaa taaaacaaaa   143220

tttagaagta ggagatgata aaagggcaga gacacagatt aaagagagga aatgatgatt   143280

attcataatg taaaattgga agataagaga ggatgagggg cacatcaagt tggctgatat   143340

gtgagctaaa atttttctaa aaatcattat acaaatacaa agttaacttt gtatttgggg   143400

agagagaagt catgaaattt taaaatatct atctcagacc caattatagg aaaaaccaaa   143460

atgagacaca attgtctcta tctcaaatat gcgacttgcc cttcatctcc agaatggcag   143520

tggggcagag gagtaggcat tattattaat gtaataattt tagataataa attcaaagaa   143580

ctgttgaata cttggatgat ggaaaataca taataattct ttagtttaca tattatttta   143640

acgaagtaga aatattttta caggcttctg attgagatag agaagaaatc ttaaaatagt   143700

cggtgagatc aaggactctc aaatagaaac taacggtaca atacccatta ttatcatttc   143760

attgaatgta ctctaattat tttatatttt aataatataa cttaataata tatatgacat   143820

attttgtatt aattaaaatg gctttcttac attattttat aacctcaatc tcccagtctt   143880

atttttctca gaatgatatg ttctttatct tttactaatt cttctagatt ttcagaaacc   143940

taacctttgt gtttagggaa gaaacatcct ataatcagtc atagttttta gagatttgtt   144000

ttccatatga tgcctgacat aattagaggt caacacgcaa atttgtatat gccaataagt   144060

gctttaaaat ttaaccaagg gtttgcatta tcgagctttt aagaaaagtt gaattcatac   144120

agcatcatat gtggattaga aaatcacaag taagcatgat catacatagt aaaatctgac   144180

tgcaaaatgt taccaaatta gtcatattta ctcaaaagtt caatttctca actgttattc   144240

aaagcttcat aaacttttgg cttctggcca ggcgcggtag ctcacgcctg taatcccagc   144300

actttgagag tccgaggcag gtggatcacc tgaggtcagg agtttgagac cagcctggcc   144360

aacatggtga aaccccgtct ctactaaaaa atacaaaaaa ttagccagac atggtggcag   144420

gtgcctgtaa tcccagctac tcaggaggct gaggcagaag aatcgcttga acccggtagg   144480

cagaggtttc agtgagtcga gatcgtgcca ctgcactcca gcttgggcga cagggtgaga   144540

ctccatctca aaaaaaataa taataatttt cgttttctta atcacacaac atattaaatg   144600

ttaaaaacaa taactttttt ctataatatg taatgtgaaa aaatttttaa catagctata   144660

tattacacct tatatgtgtt atcttaggtt tcctctatga gaattctaac ttcggatata   144720

gtaatgattt cttgctattt ttcaattaat cattcatata tcaagttatc tagttactgc   144780

ctaaaaaatg aaaaatgata aaatgggtat ttttgtaata tagtagtttt gaagaaaggc   144840

tgccccaaat aagaagaaat tatagaagga atgtagattt tcttttctct taaactgtaa   144900

atatgacggg gtctctctct taaaaaatta tacaatattt tagatatttt aaaatcttta   144960

aaatattatc acaaatacac tcattttcat cattcagtgt aagaaatgaa ggtttacaag   145020

taaaattgaa cttattttaa attaagagat atggctgttt aataatggaa attgttttat   145080

ttgaaaattt aaagtgatga ttctcagtga gtataacctc ctgttcaggg gtatgtaatg   145140

tgcagaaatc agggagataa acaactccaa tttgaaatat tatttaatat tttggaaacg   145200

aacaaatata atgcaaagca cagagagtaa agctccacac aatattcttg ctgacagaga   145260

tgcaaatttt gggacacaga tttgggggag tggctgattt tttttttttc tgaaaagtat   145320

agaaacttat ctacagcagt tgttcttgaa ggatggtctc aaaactgaaa acgttggcac   145380

atgtaggtga gaactcataa gagatgcaaa ttctgccccc aaccccaaga catactgaat   145440

cagaaactct ggggttggat gtggcaaatc attgtaacaa gccctacaga tgattctgtt   145500

gtatattcag atttcagaac tacttatatt atttgctact cagagaatgg acttgtctga   145560

tttctgcagg cttctgggtt atttgaaact tacttgatta aacagtgttc ttcagtacag   145620

gcgtatattt gtatatatac gtgtgtgttt atagaaagat gtgaatatat atgcatatat   145680

attctcagtt acaaactata ccatagtctt aataatatgc atatattccg tgtcataaaa   145740

ctcacttaac agtggcttgg agaacagacc tattagtatt ttaggggctg tatcaattat   145800

aacagacatg tcttagtcta ccttttattg ctgtaactga atacctgaga ctggttaaag   145860

tattcaataa agaaatttat ttcttaaagt tctggaagct gggaagtcta aggtgaaggg   145920

tccacatctg gtgggaactt tcttgctggt gggcacacca gagagtccca aggcagctca   145980

tggcatcaca tggcgagggg tgttcactga gagccaaact gggttttata ataaacccac   146040

tcttgtgata tctaactcac tcccatgata acccattaag cccttactct atattccatt   146100

catgaaggca gaaccttcat gacctcatca ccttttaaag gctctgcctc ttaatactgt   146160

tacattggga attaagttcc aacatgagtt tcaaaaggga caaacattca aaccacagca   146220

aaacattaaa aaaaaaattt tctgattaaa gagggagcat acatattttc aagtgttctt   146280

aagtggaaaa taatggatgt gaatgactgg gcaaatttaa gagtggcatg aggagtaatt   146340

tattctgcta aatacgtagc tttaggaatt taaaaaaaaa agccatgtta catttagtga   146400

gacatctgga aatactacat gaggatgagc actttaaaac acttcccgct tcatcagtca   146460

gtttacctgt ctctgatggt aacagcaatg aactttttgt gaacaatgac tttttctacg   146520

cctgaaatag ataaatatat aaagttggct ctcatctgtt cctattcttc cctcgaaaaa   146580

ttgaatctct cagtcactaa cttattcgta atgaagaact gcattccaga catttttctt   146640

agacatcgtc tcctgctaca caggatgtga ggcaaatgaa tattttccat ggaactaatt   146700

cagagagtaa acatatttat agatccagat ctaaggtcat ggaggagctc attgctttgt   146760

aactaaaatg tgtattgatt gtattgctgt tcatgttctt tcttaagata atttacgata   146820

agaactcaaa tttcttttgg atactggtta tggtaattgt ggctgatcta tctaacatga   146880

tgaagctctt attatatcta tattgattgt gaagccaatg agatcagcta ctctcattct   146940

ctcttcagta caattgtgat ttttctccca tgaaaaacta tttggtagat ctttggtgct   147000

aatctttaga aattgtaggg cagaagcaat cttgttgaga atttgcccca actcaaaatc   147060

atgagtcttc aaaatgtttt ttaataagat ttatactaag acatagattt agttgagtga   147120

ataccacact tttagggctt agcttcagaa tcacacactt cattttgacc tgagttttat   147180

aattaaaatg ttcaccattg ttctaattaa atttttagat ttaataagga attacaaagc   147240

aattgattac aaaagtgtga aaagcatatg catgatttct attcaaatag aataaacaac   147300

ttactttgct tacattattt cttcttattt tggttaacct tcttttaaat ctatttcctt   147360

acagaaacat ccatcttacc ctatttttag gcattgacta cacaactccg tatataccat   147420

cttattgttc ctgttgagtt gcttttagtg agtttcagaa ttgacttttt ccttttatgc   147480

ttcatcattt tattgacaca attaatgaaa atgttatttt tataggtttc tttggttact   147540

ttagtggcaa acactcttgg ctactcagat cttggcccca ttaaatccct tcggacactg   147600

agagctttaa gacctctaag agccttatct agatttgaag gaatgagggt aagaaaatac   147660

taaactttat aatgttctta ttttttaatg gggtttaaaa tataaaaaca atgggtatgt   147720

agaaattatg agttgtttct gtttacataa atacataggc tgtttatgta tgtgtgtgta   147780

catatacata tatacatatg catatatgta tatatgcata tgtatactat atagtatgca   147840

tttacatact atatacagta tgcatatata ctatatatag tatgcatata tggtatatat   147900

atgcatatta tatacactaa tagtatatat atgcatatta catatactaa tagtatatat   147960

gcatattata tatactaatg gtatatatgc atactaatat ataaatacta attatagcat   148020

taattaaata gtatattact aaaaatagta taatactcat tagtatatac tagtatatta   148080

ctaaaaaagt ataatactaa ttagtatata ctattatata ttaatatata cagaatatga   148140

aagactatat ataaaatatg catatatagt atagtatata tattatttca tttactgtac   148200

atattagtat atatatgcat actctctctc tctctatata tatatatata tacacacaca   148260

gtatttcagt gcatattgtt taacaaggga ataagttaat cacagtaatc ctgcctttat   148320

ctaatattgt caaacaatag aatgatccaa atgagtgact tttttcatat taaatggaaa   148380

tcttccctgt gctaggaagt ccaagtgaaa ggggaaacta ttgttcctaa catcatctct   148440

catacataag taatcaagga cctacttata tcaggtgttc aaataatatt tgtttaagaa   148500

actacctggg taaggagcat tagaaaagat aggtaagtga gacagcatca gccatcacat   148560

ttaatttcac ctttaaaata acattgcaaa gtaagtggaa ttataactaa attatatttg   148620

agaaaactaa agctcagaga gtttacttaa tttgcactta ggctgcagag tgcctgaaaa   148680

gatactcaat tagcagagac aaacaagtta taatgaataa caactaccat aacctagctt   148740

taaggattgt attaaaccag caactttgta acacacatgg aggacaacaa ctctattttc   148800

tgtaattagt ccatatcctc atgtgttggt actcctctaa aatttcttct ccagatttat   148860

acctgctatt ttatgcctct gttctggaat gcttcccctg ccctgtcccg accctaaccc   148920

gtttgtatag cagacaaaca cctatctgtc ctttaaggct caatttaaag ttgccttgtc   148980

cgtccaccag gagacataac tggatattct ctctctgttc agacacctaa aatcctcatt   149040

atattgtatt ttacttattt gtttacttaa ctgcctccct accttacctt ctctgagcaa   149100

tttaacacgg agattagtcc agcttactga tactttaagt gtggtttact gaccagctat   149160

tagcattatc tacaaactta ttaaaaagac ggacggatca tgaggtcagg agttcgagac   149220

cagcctggcc aatatggtga aaccccatct ctactaaaaa tgcaaaaaat tacccgggca   149280

tagtggtgct cacctgtagt ctcagctact agggaggctg aggcagaaga atcgcttgaa   149340

cccgggaggc agaggttgca gtgagccgag atcatgcaac tgcactccag cctggggaac   149400

agagcaagac tctgtatcaa aaaaaaaaaa aaaaaaaaag caaattcttg gatctcaccc   149460

cagacctact gagtcagaaa ctccaggatg gggataagaa acttgggttt taaccagcct   149520

caagtgaaca ttagagatct ttcagcctac caaatcttca ctgttatccc tacaaaccta   149580

attatgactg caatctctgc tattttaatt atccagtgta taacggtttc caagtataaa   149640

agaaagatca tgattataca aaaaagttca taagcacaat tcaaaaatat tctatctaca   149700

agttgaaaat tacaagtttc attttgtgca gaaaggtggt attagaattc attgacatta   149760

acttaatttt ttgagcatta atagaatgtt acaatctatc acaactttcc cctacaaaac   149820

cacttccttc agtgattaag ccagcccact atttaactct gtttgctctt tgttctttat   149880

ctgtattaca ggtgaattgg atgcaggaga atagtttagt atattttgag aggcaaatgt   149940

ctatttagtt acatttgtta accatgcaaa aagagacatt tattcatgcc gcagggctat   150000

tttgaaggat aaatgaaata atgaaataat gcatttgagg catattgtag tcagcttgtt   150060

tgagtcctta ggctctttag ctttcccaac tggcttctca tcagaccaat aggtgcctgt   150120

ctttctcaga gacccatgat tccatcatta ctcacatttt ttagaaaaac attttaaaca   150180

ccaactatgt gtcaggtgtt gtgatataaa aaacacagag tacagtggta catagacccc   150240

ggtccccaaa gagtgagtag ggtcaatggt tacaagagag acagacaagg gcacataatg   150300

atacaggaat atacagtagg gagtggctat ccggggaagt ctgggaagac atcacaagga   150360

ggtgacattt cagacatttc atgactgaag agtaagcccc aaatcatagg cagataggca   150420

ttcaaggcag tgataccaca tggtagggag gcacagaata gattgtgcaa ggtgtgcttg   150480

gtcagtgact agatgtatca gagtgcctac gtgataaaca tagtagggag ggcagcagga   150540

aatgagcatg aaaaggtagg ctctattaag agctggctac tttgaacttc attctctatt   150600

cctattcctc ctaatctttt ttgaggtcac atagactgta agaatctgat gaaagttaga   150660

attgtctttc cggaaagaca gcacaaccat aatgtttgtt atataatttc atgcccccag   150720

gaaacctcta caggtccatg aactccaaat aatcattgct ctggaccaaa ggtcaacaaa   150780

ccccagcctg tttttgtaaa aatgttcttg gaacacagcc ataccagttt gtttatgtat   150840

gacccatgac taccatggca gagttgaata gttgcaacgg agatataacc cacaaagcct   150900

aaaaatattt ataaaaatgt ttgcaaacct tctccctaga tgatctgatt agtagtcaga   150960

gatccttagt atttctctat tttaaagcat cttgagaacc tgcttaatac attgcagaaa   151020

agaaggatcc cagtgctcct tccctaacag gttaatcttt aacacatttg tacttgaatg   151080

ggtgctcaag ctgaagtgta agatgacagg taggttttga aagattaagt aaataagaaa   151140

atctggagag tgttaaatgc cacaggaatt gccctggatg aaaactggag tggcaaagac   151200

aaactggtga tcaatagcag tacaaatgct gaaaagcaga aataaagaaa ggattaaaga   151260

aaaactgttc ctaatttttg tcttaactga ggccagcact atatatattt agtcaaaggc   151320

ttacatataa agtatttaga gtaataataa taaatttaaa acgattgctc ttatttcgta   151380

gaaccagcca aatctaaagg atttaaacca tttaaagatt ctcaatcctt ttgtggagaa   151440

tgtctcaaaa aaagagaata agaaaagaaa ataattaaat taaattaaaa tgatgtccag   151500

tcataattcc acctacctga tatacaccaa tagtttctct atgggggaat ctttaatgct   151560

ggtaataata ggatcatgaa catttaaatg tatataaata tatatttttc atttatgttt   151620

atacatttct tttttttcca gagtgtacag attttacaag tttaccttat caataacagg   151680

ttttggttta ttatttttat ttattttaca tttatttaag ctattatatt atcttagtta   151740

ttttgtctta tattttgcta acaattttat tgtgtgataa tcatgtaatt tgtaagcctg   151800

gtgatcacag agttcatgtc ttattttgtc ttgcttggca cactgctgag tgtagagtag   151860

gcatttaata aacatgagtc ggctggttgg tttgatgtct tagatattta agggcggctt   151920

ttctaattta tttatgtctg catggcattt ctttcatgtt gcctatttaa catcttacta   151980

atcctaatca tgcttttctt tcttttgaat actaggtcgt tgtgaatgca ctcataggag   152040

caattccttc catcatgaat gtgctacttg tgtgtcttat attctggctg atattcagca   152100

tcatgggagt aaatttgttt gctggcaagt tctatgagtg tattaacacc acagatgggt   152160

cacggtttcc tgcaagtcaa gttccaaatc gttccgaatg ttttgccctt atgaatgtta   152220

gtcaaaatgt gcgatggaaa aacctgaaag tgaactttga taatgtcgga cttggttacc   152280

tatctctgct tcaagttgta agtgtcccat ttcatgagtg cttggtattt taatagatat   152340

tggacgaagg atataagtta ttctttaaat agtatattaa ttataaattg aagataaaat   152400

actgtgtggt ttttaaaaca gtgccagtct tggccgggcg cagtggctca tgcctgtagt   152460

ctcttcactt tgggaggcca aggtgggcag atcatgaggt caggagttcg agaccagtct   152520

ggccaacata gtgaaacccc atctctacta aaaatacaaa aaaattagct gggtgtggtg   152580

gcaggcgcct gtaatcctag ctgcttggga ggctgaggca ggagaatcac gtgaacctgg   152640

gaggcggagg ttgcagtggg ccaagatcgt gccactgcac tccagcctgg gctacagagc   152700

gagactcttg tctcaaaaaa aaaaaaaaaa aaaaaaaaaa gtgttggtct ttcctagaac   152760

atgttcctac atgaataaga agcatgggtt ctgttgcatt tgagttatta atttataatt   152820

gactctttgg tgtcatgtgg actcccatct tgcaccattc aaatattgct tcaaaaatga   152880

acgtttttga acttcctgct tcacactatg aagggatgag aggaacttcc cacaggcatg   152940

gagaaccctt taaaaaatgg agaaaagatg tttcctgtct tattcataaa attttccttc   153000

acctttaaaa aataaaaggt tatgtgcgaa attcacaggc aactgtaaca atttagaaat   153060

aattaactgg gactaagatt tagaatgtta cttgggaata tgtccttttt aaaaaaatct   153120

ttacattaaa tggacatgtt gaatacagca aaacttacta gtattactta ataattgtgg   153180

taacattaaa cagacaaaac tctgtttatg gctattttag aatatgagct taacattcaa   153240

attctattaa tgttattctt aaaggcaact tttaagggat ggacgattat tatgtatgca   153300

gcagtggatt ctgttaatgt aagtattgat tatcttagca ctaaacttta tttttaaaag   153360

cttcttagtt tatttcagtg atttccaaac tataacttca tgaagccctt gggactcaca   153420

tagacaatga agaacatcca cctgatagta gcctagtggt tgtgagtaca gcagttggag   153480

atagagcctg attcaaattc tagctgtacc atatcatcca agctctacaa ctgacttcgg   153540

gcaaattacc ttaccttctt gagacttagt ttatttgtct aatctataat ttaatgaatc   153600

tatcatttgt ctaataaatg tctacaatca tccaatgcct actccatagt gttgtgagga   153660

cccaacaaga aaatagaagc agggcactta gtgcaggctg gcattactaa atgctcagta   153720

aatatgcgct tatcaaaata aaaataaaat aattttaatg tatagctttt actgttttta   153780

cagtttaaaa caccttggat gagtttatgt gaaataagtt ccatgctaag aaactttaat   153840

gattactccc taggtaatat ttttacaaaa tataataaag atgtattcgg aatcaaaaga   153900

aaatacatgg caaaatgtgt ataaatatga taatgtctca tttacagtac ttttggaaat   153960

aacatataca tagtatgtca cttagttatt gaattttcct accaatatga gcacaaatat   154020

gcatatgatt aagccctttg tagttatttg aagattatat tatttattac ataagtatgt   154080

aataaattaa ataataagta tgtaatgaat acatgttgaa taaattgtta agagtgatta   154140

tgttaaacct caacaatgct atggcttctt aaatcctatg tttacctagg atagcactgt   154200

ttgaattacc tggtcaaacc atgtgaaaaa gaaaataatg aatgttactg tccatataat   154260

gctaactttt gtaaatttta taggtagaca agcagcccaa atatgaatat agcctctaca   154320

tgtatattta ttttgtcgtc tttatcatct ttgggtcatt cttcactttg aacttgttca   154380

ttggtgtcat catagataat ttcaaccaac agaaaaagaa gataagtatt tcaaatattt   154440

ttcattgtaa tgaaagggat gaacaattat tttccaaaaa agataatgta aagtttaatt   154500

tgatatcaat tcatgattaa ttttattaga acttcattta tttttcaaat aattgactag   154560

tatacaatta caaatatgct taatcttatt catttttgca cagaaaacaa ttttctaaat   154620

aataggttct ggctaactta tgatttaggt taaacccata ggttttgagc aatatatcaa   154680

ctattctgtt ttttccaatg tttcctatag aggattgaat aattaagaaa aatcaataca   154740

ctatttattc aaaacacatt ttataagtag ttatttattt tattttgtgt aatatatatt   154800

gggttggagc ttggggagac caacgtaaga tatggttcct gagctcaagg agtttatgtc   154860

atagcagaat aaataacaca ggtaatgaaa attaagactt gttgaatact gtaatttgag   154920

caatcttctg aaatttttaa ttaattaatc ttcacatcaa ctgtattagt ttctttgacc   154980

tacgagaaca ggataataca aacctgaggg cttaaaacaa gagaaatata ttctctcaca   155040

cttttggagg ttagaagtcc aaattcaaag tgtcagcagg tccatgttct ctttaaagcc   155100

tctaagaaaa tatattttat tgcctcttcc agcttctggt agcccaggtg tttcttggtt   155160

tatggcaaca gaactccaat ctctcccatt atagtgacat gccattttcc ctctgtgtgt   155220

ctttctcctc tactagtaag gatgccagtc acactggatt aagagcccac tccactccag   155280

tatgacttca tcttaattac atctgcaatg acattatttt caaataaggt cacattctga   155340

agtgctaagg gttaggactt atatgtacct tcttagggca cacaatccaa cccataacat   155400

caatcacaaa agtattatta cagagtctct ttcacaaatg aggaaaggca cacagaggtt   155460

aagtgactta cccaaggtca tatatcgagt atgtgatgaa ggttagatag agtcagtagt   155520

aaattcgatg tatcttgtac tctattaaac tctctactat gctctatccc caaatactat   155580

aatcatgata aatacaataa gaaaaattaa caagcacaaa aaatatacat gacagtcaga   155640

gtaaaaatag atgctgctat agaatggttt atgaaatacg tgacaattga gaaggctttg   155700

gaaggtggga aagaagacat gtagcaacgg agaggcaaaa gaatggctaa cccacatgga   155760

gtgaaacaga aatgaatgag caaatgaatt gtgttgataa aagaggcagc aattcagggg   155820

ggatagcaat gctttcggtt ttgaagaaat ttaagatttg gagaaatagt aaaagatgag   155880

gttttaacct gcctgagagt agatataaaa agccgtatta gacctttttt aatagcagct   155940

ggtgtttcat tcatatatgt tgagtaggga agaatatgga agcaggagat tgatgtttat   156000

taagactcca tgatatgtca gatcctgtgt aaaatacttc taacataatt gtagtcaaat   156060

tttacaacaa atctaaaaga catagtatcc tcatttaacc tctcagaaaa attatcttat   156120

ttgcacatgg cctgacagct aaaaagtagt ttcattatgg atctagctcc agaattgctt   156180

tttctagaga ctgagcttta caaaaaatta atctagcagt gatgcacaaa atgactaggg   156240

aaggaccaaa gactatttca gaccctgctt gacctgccac ctggaccaca ctaagtctcc   156300

aaattagtcc tgtgtgtcaa tggagaatag gaaatatgtt ccattaaaac attttagagg   156360

gtagaatcta cagtattgct tgtgatttgc aagagataaa ggagtctaat tctggagttt   156420

cttgtcaact aactgagata ctctggttgt ggtaccacct atacaaaaag agatctttgg   156480

agactaaatg gtagaattac aaaagagaat aataattttg ggtactggct tagcatctaa   156540

gaagacagat gtacatgtac caaaatgtca ttagtgtgca tgattgacta tttgcaagta   156600

gacaaaaatt tagtaaatat tgcattattt atcctgacat ttacaaatac agatgtttat   156660

ttttaaagat ttttaaattt catgttccat tttacattta taaagtgtac actgattttc   156720

aatttatttt tctcaactta agcattatat atacatacat gtaatatata agcacacaca   156780

agtaattcct cagtcttccc tgcataggat aaattaagcg tgtctagaaa gagcagtatg   156840

agcataaata aaacagccaa catccaattg actttaatct tcctgcttgt taatgttatt   156900

cttacaacat ttctactgca ggaagtaaaa taggatgggt tgatactatc accaccaaag   156960

tcaggaaaca gttactgatt tagaagcatc aaaaactcat atcccctatc attcttccag   157020

tatttcatct tgcaatctaa gtatagcttt tattttctga ccttttctga atgatttaga   157080

atttctttcc actcttccct gaaaaaacat gaccaacact tcaattagtt aacacatgct   157140

atgtagaagt acgtagtaga tgctttgtga tgaactcatt tattccaaag aaaaaaaaca   157200

aatgaaagtg gtatcctttt ctttgccttt cctaatttta attattgtgg taaggaaact   157260

taatatgaga tctacctgct taacaaaatt tttaagtata ctatatatat tgttaactat   157320

agttacgaag tactacagga agtccctaga acttattcat cttgcataat tgaaacttta   157380

ttcccattga atagcaattc tccattctcc catcctttca tgccctggca atcaccattc   157440

ttctctctgt ttccatgagt ttgaccattt tagttacttc accgaagtgg aattatgcaa   157500

tattttttct gttacttcac tcagcataaa tttatccagg ttcattcaag ttgctgcata   157560

tggcaggatt tccttcttta taaggctgaa tagtgtgtgt ttgtgtgtgt gtgtgtacgt   157620

gcacacgcac atgcaggtat acaaatacca cattttctat cccatcattc atcaatagac   157680

atttaggttg ttttcatatt tggatacagt aaatagtgct gaagtgaaca tggaagtaag   157740

gactctgaga tcctgagttc aaatttttaa aatatgctca gatgtggcat tgctagatca   157800

aatggtagtt atatttttaa ttttttcagg aactttcata ctgttttcta tggcagctac   157860

atcattttac attccaacaa tgtacaaagg ttctaatttc tccatatcct tgccaacacc   157920

tattatcttt tgatttgggt ggtttttgtt tttgttttgg taatagccat cctagcaggt   157980

atgaaatgat atctctttac ggttttttgt tgctgttttt tttttttttt tttttttttt   158040

ttgttgtttt tttttttgag acggagtttc gctctgtcgc ccaggctgga gtgcagtggc   158100

gcgatctcga ctcactgcaa gctccgcctc ccgggttcac gccattctcc tgcctcagcc   158160

tcccgtgtag ctgggactac aggcgtgcgc caccatgccc ggctaatttt tgtattttta   158220

gtagagacgg ggtttcaccc tgttagccag gatggtctcg atctcctgac ctcgtgatcc   158280

gcccgtctcg gcctcccaaa gtgctgggat tacaggcgtg agccaccacg cccggccttg   158340

ttgctgtttg tttgtttgtt tttgaaggag tctcactctg tcaccaggct ggagtgcagt   158400

ggcgcgatct cagctcactg caacctccga ctccctggtt caagtgattc tcctgcctca   158460

gcttcccaag tagctgggat tacaggcatg tgccaccatg cccagctaat ttttgtattt   158520

tcagtagaga tggagtttca ccattttggc caggatggtc ttgatctcct gacctcatga   158580

tccacccacc ttggcctccc aaagtgctgg gataacaggc atgagccact gcacctggcc   158640

ctcattacag tttttatttg aattttctga tgattagtga tactgagcat cttttaatat   158700

acatgttggt catttgcatg ccttcttaag ttgcaggagt tccctatata ttttggatat   158760

taaccattta ttagatatat agttggaaat attttctccc attctatagg ttgctttttc   158820

accctcttga atgcttcctt tttttcccaa agctttttag tttgatatgg tctcaattgt   158880

ctatttttgc tcttgtttga attttggagt cattgccaag aaatcattgt caagaacagt   158940

atcatgaagc tttcctgcta tgttttcttc tacaagtttt acagttttca ggtcttaggt   159000

ttaaatgttt aatctatttt gagtttattt ttgtgtatgg tataatataa gaattcaatt   159060

ttattttttt atatgtgaat atccagtttt cccaacatta tttgttgagt ggcctctttt   159120

ctattgtgta ttcttggcac ccctgttgaa tatgagttaa ctatttatgc atgggtttat   159180

ttctgggctc tctatcctgt ttcattggcc tatatatttg ttttatgcca ggaccatact   159240

attttaattg ttgtagcttt gttatacatt ttgaaatgag gacctgtggg gactgggtgc   159300

aatggctcat gcttataatc ccagcaactc gggaggctaa ggctggagga tcacttgtgg   159360

ccaagagttt gagaccagcc tgggcaagat agactccttc tttacgaaga tatttgaaaa   159420

gtagccaagc atgatggcac acacctatag tcctagctac ttaggagcct gaggtgggag   159480

gatcactgaa gcccaagagt atgaggctgc agtgagctat gatcatgcca ctgcactctg   159540

gcctgggcaa cagggtgaga tcttctctct caataaataa ataaataaga aatgagaaaa   159600

tgtgattctt ccattttgtt cttttttctt aagattgctt tggctattca gagtcttttg   159660

tggttccata tgaattttag gatctttttt tattttagta aataatgcta ttgggatttt   159720

gatatgtact gtattgaatt cacagatcac ttagggtagt atgggcattt taacaatatt   159780

aagtcattta attcgtgaat actgggtctt tccatttatt tgtgtcttct ttaatttcct   159840

tcatgaacat tttgtagttt tcagtgcata cattttcaat gccttggtta agcatatcct   159900

aagtatttta tttcttttga tgttatcata aatgggattt ctttcctaat tttctcttca   159960

gattgtttat tgttagtgta tagaaacgca ggtgattttt gtatgttgat tttatatcct   160020

tcaacatcta gtaaatttgt ttattagttc taacagattt tcctgatgtg tggagtcttt   160080

agggtactct ccatataaaa taatgtcatc tgtaaacact tttttctttc agattgggat   160140

gtcttttact tgtttttctt gcctaatttc tctggctagg acttctagtg ctgtgttaaa   160200

tacaagtggc aagagtagcc atatttgtct tattcctgat cttacaggaa agtttttcag   160260

tttttcacca ttgaatacga tgttagctgt gggattttca agtagtcttt gttatcatga   160320

agtatatttc ctctgttctc atccatttgt gctactataa cagaatacca cagactgggt   160380

aatttataat gaacataaac cttatgggat cacagtactg gaggatggaa agttcatgac   160440

tgaggggctg tctggtgagg tcttatttgt tgtgtcataa catgctgtaa ggtatcatgt   160500

tatgatacac atggcacaaa gagagaataa gtgagaaaag gaggcagaac ctgcctgttt   160560

ataatgaact caatcctgag ataacagcat taatgcattt aaaagggtaa aattctcata   160620

acttaaacac ctcttaaagg tctcacctcc caattctgtc acaattgcaa ttaaattgca   160680

acatgagctt tggaggggac aaaccttcaa gttatagcaa cttctatacc tagcttttgt   160740

tttctttttt tagtttttac catgaaaggt tgttgaaatt tgtcaaatgc ttcttctgaa   160800

tctcttctga tgatcatgtg atttttatcc ttctcagatc atgtggtgta tcacattatt   160860

ggtctgcata tgttgaacca tccttgcatc ctagggacaa ctcccacttg gtcgtagtac   160920

atgatcattt aatgggctgt tgcattcagt ttgctaatat tttgatgaag ttatttgcat   160980

ctatgttcat cagggatctt gttctgtagt atgttttttt ctgtttaaat atttgttcat   161040

ttttaattga caaaaattgt gcttatttat ggggtacaaa acaatgtttt gatctacata   161100

aacattgtag aaattttcag tcacgctaat taacataacc atcacttcac ccacttatca   161160

tttttttgtg gtaagaaagt taaaaagcta ttcttttagc aattttgaaa tatacattta   161220

tttttttcat ttcctattgt gtgacttttt tgacttttat tttaagttca ggggtacatg   161280

tacaggatgt gcagtcttgt tacataggta aacatgtcat aggggtttgt tgtacagatt   161340

atttcatccc tgaggtatta atcccagtat gcattggtta tttttcctga ccctctcctt   161400

cctcccaccc ttcaccctcc cataggcccc agtgtgtgtt gttacccttt atgtgtccat   161460

gtgttctcat catttagctc ccacttataa gtgagaacat gtggtatttg gttttctgtt   161520

cctgccttag tttactaatg aaaatggcct ccagctccat tcatgtccct gcaaaggata   161580

tgatctcgtt tttttttgaa tggctgcata gtattatatg gtatatattt accacattat   161640

ctttatccag tctatcactg atggtcattt gagttgattc tatgtctttg ccattgtgaa   161700

tagtgctcca ataaacatat gtgtgcatgt gtctttataa tagaaaaatg tatttccctt   161760

taggtatata cccagtaatg ggattgctgg gttgaatggc atttctgtct ttaggtcttt   161820

gaggaattgc cacacagtct tccattatgg ttgaattaat ttacactccc atcaacagtg   161880

tgtaggcatt ctttttttct ccacaccctc gccagcatct gttatttttt gactttttca   161940

taatagccat tctgactggt gtgagatggt atctcattgt ggttttgatt tgcatttctc   162000

taatggtcag tgacattgag ctttttttca tatgcttgtt tgttgcatgt gtgtcttctt   162060

ttcagaagtg tctgttcata tcctttgccc actttttaat ggggttgttt atttcttgta   162120

aactcattta agttccttat agattctgga tattagacct ttgtcagatg catagtctgc   162180

aaaaattttc tcccattctg tagactgtct gcttactctg ttgatagttt cttttgctgt   162240

gcagaagctc tttagtttaa ttagatccca tttgttaatt tttgtttttg ttgcagttgc   162300

ttttggtgtc ttcatcatga aatctttgcc catgcctatg tcctgaatgg tattgcctag   162360

gctgtcttcc agggttttta tagttttaga ttttacattt aagtctttaa tccatcttaa   162420

gatttattcc tctactctaa atgaaaaatg tacatccttt gatcaagatt tatactttct   162480

ccacatcgtc ttcccccagt cctatggcaa ccacctttat atgctgtttc tgtaatgttg   162540

acttctcact tttttatttt ttatttattt atttttttat tttactttaa gttctagggt   162600

acatgtgcac aacgtgcagg tttgttacat atgtatacat gtgccatgtt ggtgtgcggc   162660

acccattaac tcgtcattta cattaggtat atctcctaat gctatccctc ccccctcccc   162720

ccaccccatt ttacatgtaa gtgagatcat gtggtatttg tctttctgta cctggctaat   162780

tttgcttagc ataacgtcct ttagtttcat tcatgttggg atgaatgaca aaatttgttc   162840

ttttaaagtt ttgtatagta gtgcactgtg catacctatc acattttctt tattcattca   162900

cctgttgatg ggtacaggtt gcatgtatgg gttagtgcaa aagtaattgc ggttttggcc   162960

attactttta attgcagcaa aagtaatggt aaaaactgca attacatttg caccaaccta   163020

atatgtcttg gttcttgtaa ataatgctga aatgaacatg ggagtgcagg tatacctttg   163080

acagaacgat tttaattcct ctaaaggaat taaatatata ccactatata cctagaagtg   163140

gaattgctga attatatggt aattgtattt gttttgggaa cttccatgct atttttctca   163200

aacagctgta ctaatttaca ttttcactaa caatgtataa gggttcctat ttctccacat   163260

cctcatcaac acttgttatc attcatcttt ttgataacag ccattctagg aggtgtgagg   163320

taatatttca ttgggatttt aatttgcatt tttctgatga ttagagatgt tgagcatttt   163380

ttaatatatc tattggccat tcatatctct tcttttgaga aatgtctgtt cagattattt   163440

gcccattcta caattggttt attgattttc taggtgttga gttgcttgag ctttttatgt   163500

ataatgttgg atattagccc tttatcagat gtatggtttg cagatatttt atttcaatcc   163560

atgatctctc tctccactct gttattgctt cgtttgctgt aaagaacatt tttagtttga   163620

tctaatccaa cttgtctctt attgtctttt gttacctgtg cttttagagt cctagccaag   163680

aaatccttgc ccagataaat gtcatacagc ttttctttta tgttttcttc tagtagcttt   163740

atagtttcat ttcttatatt taagtctttt acttgtttgg ttttataaac atatggtatg   163800

agaaagggcc caatttcatt cttttgcata aggaatattc agttttccca acaccattta   163860

ttgaagagat cgtcctttcc cccattgttt attctttgca cctttgctga aaatcaattg   163920

actataaata attgggttta tttctgggct ttttatcctt ttccattagc caatatatct   163980

gtgtttatgc caatagcata gctttatatt ttgaaatgac agagtattgc acctctagct   164040

ttgttctttt tgctcagatt gctttggcca tttagcatct tttttatttt attcaaatgt   164100

taggattttt tactatttct gtgaaaactg acattagaat tttgataggg attgcattga   164160

atctgtagat tattttgggt agtatggaca ttttaacaat attaattctt ccaacacatg   164220

aacatgaaat atattacaat ttatttgtgt cttcctcagt ttttttaaat caacttatag   164280

ttttcagtgt acagatcttc aactttcctg gttaaattta cttcaaagta ttttatttat   164340

ttattttgat gctgttttaa ataggattaa tttcttaatt tctttgttgg atacctcatt   164400

gttaatgtat agaaatgcta ctgatttttc tatgttgatt ttgcaaactg caactttact   164460

gaatttatgt atcagtttta acagttctca gtagagtgtt cagggttttc tacatataaa   164520

gatcatgtca ttagcaaaca gagataattt tatttcttgc tttcttacat ggatgtattt   164580

tatttctttt tcctgcctaa ttgctatgga tgggatttct agtactatgt caaaaagaag   164640

tggtaatagt cgatatcctt gtcttgttcc tgatcttaga agaaaagctc ccaacttttc   164700

agtttttgca taatgttagc cgtgggcttg tcatatatgg ctttattttg ttaaggtaca   164760

ttccttccat atctgctttg ttgagatttt attatgaaca tatgctggat tttatcaaat   164820

gctttgtctg catctagtaa gatgatcata tgatttttgt tcttattttg ttaatgtagc   164880

atatcacatt tattgattta tgtatgttta accatttttg catccctcag ataaatccca   164940

agtaatcatg gtgaatgatg ttttaaatgt gctagggaat tcagtttgct aatatattgt   165000

tgtgaatttt tggatctatg ttcatcaaga atattggcct gcagttttct tttctggtag   165060

catactctta gggttttcat atcagtataa tactggcctc ataaaatgaa tttgacctcc   165120

ttttcaattt tttggaagaa tttgagaaga attcatatta cttctttaaa tagaattcac   165180

cagtgacctt ttcctttttt ttttttttgg ttaggagact taatttatta ctgatctatt   165240

ttctttatcc agtattggtt tgttcagatg taatatttct tgatttagtc ttggtaggtt   165300

gcatgtttct aaagattagt tcattccttc taggttattc aatttgatgg tgtatggttg   165360

ttcacattaa tagtttatga ttccttgtat ttatgtgtta tcagtgttag tctcccttct   165420

ttcatttcag atattgtttg agttgtcttt tttcccttgg ttagtctagt taaaggtttt   165480

tcgattttat cttttcaaaa aaacaacttt ttagtatttg ctttgtttat ttctatcatt   165540

atctttgtta ttttcttcct tctgcaaagt ttggggatat tctgttcttc tttttctaat   165600

ctctaagatg taatattagg ttgtttattt gagattttcc ttctttcttt aatgtaggca   165660

tttattacta taaatttttc tctcagggct tctttttcta cattccatac tatttgttat   165720

cttgtgtttc cattgtcatt gatcccaaaa tattttctgt ttttccgtat aatttcttct   165780

ttgacccatt gcctgttcag gagcatgttg tttaatttcc acgtaattat gagttgttca   165840

aggttattct tattgacttc tagtttcatg tcatcatgaa cagaaaacat actcgatatg   165900

attttaatct tcttaaattt gttaaaactt gtttggtggc ctaacatgtg atctatcctg   165960

gagagtgttt catgtgattt gagaagaata tgtattttgt tgctgttgga tgaactgttc   166020

tataaatatc tgttagatct attggattaa agtgtagttc aagccttcct ctaataagaa   166080

actgcataaa ttatgtcagg agcaagccag ggaagaagcc accttcctgt tcttggtggt   166140

agagaccttc cacatctttt aaaagaaaga ttgtggccgg gcgcggtggc tcacgcctgt   166200

aatcccagca ctttgggagg ccgaggcggg cggatcacga ggtcaggaga tcgagaccat   166260

cctggctaac acggtgaaac cccgtctcta ctaaaaatac aaaaaattag ccgggcgtgg   166320

tagcgggcgc ctgtagtccc agctactcgg gaggctgagg caggagaatg gcatgaaccc   166380

gggaggcgga gcttgcagtg agccgagatt gcgccactgc actccagcct gggcgacaga   166440

gcgagacagc gagactccat ctcaaaaaaa aaaaaaaaaa aaaagaaaga ttgtagagtt   166500

gggattgtct ctggaggaag ccagggaaga aggcgtgggg aatgttattc ctcttgttta   166560

ggctgaagaa ggtttattct tcatttgcta tgtagatttc caagtactgg aagaggccag   166620

aaccacaggg agcggctgga aaacgtgtag cctaatggtt tccatgggga agttggaaga   166680

tggtctgatc ccaggaatta aagcttctga gagtgctcag gcagttcaaa accccccatc   166740

gttttttgta cttgagagaa aactccaatg gcttatctct gccattcctc aagcatggtg   166800

atctaaaagc caagctctgt gtcagggcct ataaaagttg ggttctacaa aatggaaaac   166860

caaggcaatt atgaagatga ttttataata tagttcatct cttctctctt tacactctag   166920

aaaaagcatt ttctagaaat aaatacattt ccttaaatta aaaaaaagtt gggttctata   166980

tgtgtgctat agtttctcaa cccttgggaa gtagctgcaa atttggtttt cttcccaaat   167040

gtaaggcact gtgctcaggg tggggttagt gcatgagtgt ctttccactt tttctaccca   167100

ttttgatatg ggtattttct gtcctctggt gtgcatgagt ttttctactg gattctgggt   167160

ttctctggag agaactgatc catgtgtatg tagatgttta cttggtacgt ccatgagaga   167220

aaaaatagtc ataaacctcc tattccacaa tgttgctgaa gtcacttcct tcaaaagctg   167280

taattttctt ttcttacagt gtctttgtct ggctttgata tgagaataat tctggcccca   167340

taaaatgact ttcgaagtgt tctttcctct tcaaagtttt aagagagttt gagaagaatt   167400

aatgttgttt cttctttaaa tgtttggttg gacttctcca gagaagccgt ctggtcctgt   167460

acatttcttt tttgggagtt actatcatta tcattattat tattattatt attattatta   167520

ttattattgg ttcaatttgt ctattcagtt attctatttc ctcatgattc agtcttggta   167580

ggttgtatat ttttggaatt tacctattcc ttctaagtta tccaatttgt tggtgtataa   167640

ttgttcatgg tagtctcttt gatccttctt attcccataa aatcagttgt aaattctcct   167700

ctttcatttc tggttttaca tatttgagtc ctctatcttt tttcttagtt atgcttgcta   167760

aggatttgtc tattttatct ttcgaaaaaa ccaattctta gttttgttga ctttttctat   167820

tgctttttta ttctctattt cacttactta gctctaatac ttattatttc cttccttttg   167880

ctgatgttgg gcttagtttg ttctttttct agttcctaga catgtaaatc tatattgttt   167940

atatgagata tttcttttta taatgtagac atgtatctca ataagatttg cttttattac   168000

tgcttttgct gcatctcata aattttggaa attgtgcttt catttttgtt tgtttcaaga   168060

tacttttaaa ttttcctatt gatttttttt ctttgaccca ttgctttttc aagagagtgt   168120

tgtttaattt ccacatattt gtgaattttt cagttttcct tctattactg acttccagtt   168180

tccttccatt gtggtcataa aagatatctg gtatgatttc aacttcttaa cagttgtcaa   168240

aacaaacttc atgacctgat atgtgatcta tcctgagaat attctgtgcg cacttgaaaa   168300

gatggtatat taagatgctg ttgggtagca tattctgtgt gtttgtgatc catttggtct   168360

atagcgttgt tcaaatccac agtttgttta tagattccat atctggctgt tctgttcatt   168420

attgcaagtc gggtattgat gtatcctact gttatggtgt tgctgcatgt ttatcccttc   168480

agatctgtca atgattgctt tacgtattta catgctttga tgatggattc acatatattt   168540

ataattgtta tatcttcttg atgaattaac tcttttatct tattttatga cctactttgt   168600

ctcttgtgac agttttttat ttaaaatcta ttttggctga tataattaca gggtgtcctc   168660

tgtgtctgtg ggttttacat ctgtagattc agccaatgct gattgaaaac actgtattca   168720

tggaatgtga aatccacaga tacagagggt caaatttttt tatccacagg tcctgcaaga   168780

ctgactgtgg gacttaagca tcctcaattt tggtatccct tggggttctg aaaccatgac   168840

cctgtagata ctgaaggacg actgtatagc cccattgctc tcttttggtt accatttcta   168900

caaaatgtat cttttttatc aattaacttt caaactatgt tttcttaaat ctgaaacgag   168960

tatctggaga cagcatataa ctggatcttg ttttcataaa tctatgcagc cattgtaggt   169020

cttttgattg ggaagtttaa tccatttgta tttgaaataa tcattggtag gtaatgactt   169080

actattgcct ttttgttaaa tttttctgtt ttgtaattct ttttttctgt ctttttctct   169140

cttaactgtc ttcttttgtg attggatgat attttattgt gatatgctat gatttctctt   169200

ttttatttct gtatttttac gtggattttc cttgtggtta tcatgaggca atcacaaata   169260

tcttataata gtctacttta agctgataac aacttaactt caatcatata tcaaaaatct   169320

tcacttttaa tacctccctc acactttttg ttatgtcaca atttacatct ttttataatg   169380

tgtttctaca aacacatttt tgtaatttta gttattctta attattttga catttaactt   169440

ttatattaga attataaatg atttatataa tactattaga gtattacagt attctctatt   169500

tgtccatgta tttaccttta ctagtgagat ttgtgctttc atatgctctt gtgttgctct   169560

ttaccatgct ttcgtttcaa cttgaagaac tcactttagc atttcctata agataaatct   169620

agtggtgatg aactccctca gcatttgctt gtatgagaaa gtttttatcc ttccttaatt   169680

ttaaaggaca gtttttccag gtatattatt cttggtcagc agtttttttc tttaagtatt   169740

ttgaatatat actttcactt tatttgctct tttaaagttt ccactgagaa atctgctgtt   169800

catcttaaga gagctctttt ggacatgaca attcagtttt tttcttgctg ctttcaaact   169860

tccctttcac ttttggcaat ttgatgatat tatgtctcta gtggagactt tctttctttt   169920

ttttccgaga tagagtttca ccgtgttgcc caggctggag tgcagtagca tgatcttggc   169980

tcactgcaac ttccacctcg tgggttcaag caattctctc tgcctcagcc tcccgagtag   170040

ctgggattat aggcacccac caccacaccc agctgatttt tgtaattttt ggtagagatg   170100

tggttttgcc atgttggcca ggctggtctt gaactcctga cctcaggtga tccactcccg   170160

ctcagcccct caaagtgctg ggattacagg tgtgagccac catgcccagc cgagacttct   170220

ttagatttgt cctatttggg attctttgag tttcctgaat ttagatgttc atatctctcc   170280

ccaaatttga acatatttta gtcatttaaa aaatattttt acaccccttt ctgtcttctc   170340

tgtgatttca taatgcatat attgttccac ttaatgatgt cccatgaacc ttcactcatt   170400

ttttttttta tttcttcttg ctccactgac tggataattt taaatgatct accttttttt   170460

ttttttttgg tgtccatctt ttgagggttt tttaatttta ttttttattt ttttattttt   170520

attttttatt atactttaag ttttagggta catgtgcaca acgtgcaggt tagttacata   170580

tgtatacatg tgccatgttg gtgtgctaca cccattaact catcatttaa cattaggtat   170640

atctcctaat gttaggtata tccccctcct ccccccaccc cacaacaggc cctggtgtgt   170700

gatggtcccc ttcctgtgtc catgtgttct cattgttcaa ttcccaccta tgagtgagaa   170760

agtgcagtgt ttggtttttt tccttgcgat agtttgctga gaatgatggt ttccagcttc   170820

atgcatgtcc ctgcaaagga cttgagctca tcctttttta tggctgcata gtattccatg   170880

gtgtatatgt gccatatttt cttaatccag tctatcattg ttggacattt ggcttggttc   170940

caagtctttg ctattgtgaa tagtgccgca ataaacatac gtgtgcatgc gtctttatag   171000

cagcatgatt tataatcctt tgggtatata cccagtcatg ggatggctgg gtcaaatggt   171060

atttctagtt ctagatcctt gaggaatcgc cacacggact tccacagtgg ttgaactagt   171120

ttacagtccc accaacagtg taaaagtgtt cctatttctc cacatcctct ccagcacctg   171180

ttgtttcctg actttttaat gatcaccatt ctaactggta tgagatggta tctcattgcg   171240

gttttgattt gcatttctct gatggccagt gatgatgagc attttttcat gtgttttttg   171300

gctgcataaa tgtcttcttt tgagaagtgt ctgttcatat cctttaccca gtttttgatg   171360

gggttgtttt tttcttggtt tgttgattct ttctccagtt tgatcaagtc tgctattgaa   171420

tcctctaggg agttttttag ttcaattatt gtattcttca attccagagt ttttactgat   171480

atttgacttt ttgtgtgtgt gtgtatagtt tctttccctt cattgatatc ctcattgtgt   171540

tcatgtatca tcttcctgat tttgtttagt tgtctatctc tgttctctgg tactttgcta   171600

aacttcatta ggataattat tttgaattct tttttaggca atttataaat ctctatttct   171660

ttagggtcag taactgcgga tttcttttat ccctttttgt tgtttcccta attctttgtg   171720

ttccttgtgc tttgcattgg tgtctgtgca ttggaagaat agccacctgt cagccatccg   171780

acacaatgtc acaaaggaca caaaacagcc accaagattt atggactgac tttgacaggg   171840

caagaccttt gccagtcagc ctggctagag atactgagag tctctcaaac agctaatcta   171900

ccgtcccctt ttcctatgtt tgtagctgta tcaattgttc taatcatact ggttctttca   171960

gtgctccata tgaggcaaga gtgaaactgg accctagtgc agcacactga atggcaagga   172020

catttgatgt gctccactcc tctccctccc ttgaaagtgg tatcttgatg aaaatgaata   172080

aattagcccc tagaaaggat ggataaattg tttcaaacca agtaacagga taccagcaca   172140

gttatgattg aaatgcctgt ttgatttgaa aacccatatc ttttccacaa tgcaatgttg   172200

ccacttactg ctttttaact tcaataattt gatcaaagct tatggctcta tcaactaccc   172260

atgcctcttt ctaataacca accctatttt actagttttt ccaactattc atcatcctca   172320

taagtacttt tttcacctct aatgatttca tgtgaaatta gtttttaata atcataaaac   172380

atactactat tagaacaaaa gtcattaatg agttcaagtt ataaaaagga agattacatg   172440

atatacaaat atataattac aaatttgagc aactatggag taaatgttaa caataacctc   172500

atttcattaa ctctcatctt atcaggaagt ttaatagcac caacagtaat agtaactaaa   172560

atttaatgaa gacttaccat gtgccagata ttatgctaag tattcttcat gcattacctc   172620

aatttatctt ctcagcaaac acaaatgcag tgactactct tataatgatg aggtggtttt   172680

acttaaagaa ttaagaaact tacccaagga caaaagaaag gacttgaaca aagatgatct   172740

gacaccagaa gtgaagaagt ctttattact atgtaataca gcctcaatgt agattgtaac   172800

acagaaaaaa actagcctga cttacagaat tccttccacc taggttttaa agggatacat   172860

tttgcacaag gcctaaataa gctataggaa aacaaaacac ccacgcaagt ttctctattg   172920

aattaattca taatctccta ttagttttat cccattcttc atcatattga caaccaggat   172980

atcattaggg gaaaacaaaa tctattactt tgattttctc ttcaaagttg gagttttctc   173040

ctcagttttt ctccagcttc ttctgtcaag ttcttggcat gctgtaattt tcagtcccca   173100

ttaatgaaca gtaaaggatc tgggtttctc ttgacattga catgaagtct gtctctctca   173160

tgccttgcca gtaggtgaga tgaatatgaa aattacataa agactgcata ttaaatagag   173220

gaaagctgaa ttaaaacact ctaaggtggc cggatatggt ggctcacgcc tgtaatccca   173280

gcactttggg aggccaaggc tggcagatca cttgaggcca ggagttcaaa accagaccag   173340

ccaacatggt gaaaccctgt ctctactaaa aatacaaaaa ttagcctgat gtggtggcat   173400

gcacctgtaa tcccagctac ttgggaggct gagacatgag aattacttga acccaggagg   173460

tggaggttgc agtgagccaa gatggtggca ctgcactcca gcctgtgcct cagagcaaga   173520

ctccatcaaa aacaacaaca acaacaacaa caacaacaaa aacactctaa ggcagaaagg   173580

gaagtctggt taccattagg tgtttgatga ataagaaaat tcaatataat gggaagcttc   173640

ccattcaata gcaaacaatt aaaaaaataa gtaaataaga ggaagctgaa tattaccaaa   173700

tccaagagaa taaagggaaa ccataaccag gtcatcttta attccagcac cctacaagtt   173760

aagtaatgat ctcagaacta taaatccttg aaaataaatt cttaattata tggattatac   173820

taatttatgc tgtgacttaa aaaggtgaaa ttatagacta atgtagaata tacataaatc   173880

tgtaaaactt acagctaact taagaaatta gcagagaaca aagggagcaa ctgaagcttc   173940

tagcccccct ttgtaagatt taggcttttc cagtcaaaaa cctcatttag atgttatgtt   174000

atttactgtt gaattttaaa agttatattt tcttttatgt aatcaattgg aaagtccttc   174060

agtttgggta tgataattga taacttcctc agtacctaga aatctatcaa ggataatgtt   174120

gacatccaat aaagtgttta tgttgaaatc ctttatttag aattaaaaag gtagtcaaag   174180

agtttcttga aatagagata tagaaatgta tattatcatt ttagtttata ttcatttttt   174240

atgtaaagga ataatggtat attaaaatga atataaaatt aatacaattt tggttattgt   174300

atgtagcccc tattcttttt ttattattat actttaagtt ctagggtaca tgtgcaaaac   174360

atgcaggttt gttacatagg tatacatgta ccatgttggt ttgctgcacc aatcaactca   174420

tcatttacat taggtatttc tcctaagtaa tccctcccaa agctcccaac cccctaactg   174480

cccctggtgt gtgatgttcc cctccctgtg tccatgtgtt ctcattgttc aactcccact   174540

tatgagtgag aacatgcaga gtttggtttt ccgtccttgt gatattttgc tgagaatgat   174600

ggtttccagc ttcatgcatg tccctacaaa ggacatgaac tcatcctttt ttatggctgc   174660

atagtattcc atggtgtata tatgccacat tttctttatc cagtctatta ttgatggaca   174720

tttgggttgg ttccaagtct ttgctattgt gaatagtgct gcaataaata tacatatgca   174780

tgtgtcttta tagtagcatg atttacaatc ccttgagtat atacccagta atgagattgc   174840

tgggtcaaat ggtatttcta gttttagatt cttgaggaat catcacactg tcttccacaa   174900

tggttgaact attttacact ctcaccaaca gtgtaaaagc gttgctattt ctccacatcc   174960

tctccaacat ctgttgtttc ctgacttttt agtgattgcc attctaattg gcatgaggtg   175020

gtatctcatt gtggttttga tttgtgtttc tctgatgacc agtgatgatg agcatttttt   175080

catatgtctg ttggctgcat aaatgtcttc ttttgagaag tacctgttca tatcctttgc   175140

ccactttttg atggagttgt ttgttttttt cttgtaaatt tgtttaagtt ctttgtagat   175200

tctggatatt agcccttttg tcagatggat aaattgcaaa aattttctcc cattctgtag   175260

gttgcctgtt cactctgatg atagtttctt ttgctttgca gaagctcttt agtttaatta   175320

gatcccattt gtctgttttg gcttttgttg ccattgcttt tggtgtttta gtcatgaagt   175380

ctttgcccat gcctatgtcc tgaatgatat tgcctagagt ttcttctagg gtttttatgg   175440

ttttaggtct tacatttaag tctttaatcc atcttgagtt aatttttgta caaggtgtaa   175500

ggaagggatc cagtttcaac tttctacata tggctagcca gttttcccag catcatttat   175560

taaataggga agcctttccc cgttgcttgt ttttgtgagg tttgtcaagg atcagatggt   175620

tgtagatgtg tagtgttatt tctgaggcct ctgttctgtt ctgttggtgt atgtatctgt   175680

tttggtacca gtaccatgct gttttggtta ctgtagcctt gtagtatagt ttgaagtcag   175740

gtagtgtgac gcctccagct ttgttctttt tgcttaggat tatcttggct atgcaggctc   175800

ttttttggtt ccatatgaac tttaaagtag tttttttcca attttgtgaa gaaagtcagt   175860

ggtagcttga tggggatagc attgaattta taaattacct tgggcagtaa tgccattttc   175920

atgatattga gtcttcctat ccatgagcat ggaatattct tccatttgtt tgtgtcctct   175980

tttatttcgc tgagcagtgg tttgtagttc tccttgaaga ggtccttcac atcccttgta   176040

agttggattc ctaggtattt tattctcttt gtagtaattg tgaatgggag ttcactcatg   176100

atttggctcc ctattcttta taaaagttct aaatatttgc caaatcatca aagaagatat   176160

tcattacttt taattcttac aaattttctt agcaataaaa gtcacagtaa gacagctagc   176220

agataaaaaa gataaaagta catagtttaa aacaacactg attagcacac caaaagaata   176280

ttgagccaat ccttattata tgtaatacaa atatttatat atgcacattt aactgtgttt   176340

ggagacccat gtttctacac atatgtaatt atttaagata tattttatgt atagctatca   176400

tgaacataat aaaatacatt ttatttctat attaacacat tttaacctat tttagtaatc   176460

tatagaaaga tgtagacaat gattctggtt ttaactacat ttattttttg tttgtttctt   176520

taccttggag gtcaagacat ctttatgaca gaagaacaga agaaatacta taatgcaatg   176580

aaaaagctgg ggtccaagaa gccacaaaag ccaattcctc gaccaggggt aaaaaaatat   176640

atatatcttt agcatataga ttttcaaatt atttctaatt catttttaat gcacatcttt   176700

aatttctgga taatacttga aaagtttact ctgcattcga tattattctt atttctttgc   176760

agaacaaaat ccaaggatgt atatttgacc tagtgacaaa tcaagccttt gatattagta   176820

tcatggttct tatctgtctc aacatggtaa ccatgatggt agaaaaggag ggtcaaagtc   176880

aacatatgac tgaagtttta tattggataa atgtggtttt tataatcctt ttcactggag   176940

aatgtgtgct aaaactgatc tccctcagac actactactt cactgtagga tggaatattt   177000

ttgattttgt ggttgtgatt atctccattg taggtaagaa tatttatttt tcagatttta   177060

ttttttgagt aaagctaaac ttcacttatg ctcaaggaag tatatgctga attcttgaac   177120

acaaatttac tcttgagtaa gtcagtacaa tgaaagaatg aaaaaatcct aaaaagcaaa   177180

acaaatatct gtctctcata ctacagtgtt tctgggttta cactacaggc cccaaagcca   177240

aatatttcta tctattagaa ggaaattata cttgttgata tttagtttcc aatattacct   177300

ttgcaaaact agttaccatg tttatatata gctgtgtctt ggaaaaccaa tgttgaatct   177360

gaaataactt ctggttttag cacatgtgag acttgtcatt tgattaatga taatattaat   177420

agccagaata tctgtgaatt tgtgaaaatt cttccagaat ttaaagtgaa gttaagatct   177480

ctagaaatgc cagttttatt ttttacagct taatacttca caagtgtata aaatgccaat   177540

cattcctcaa ccagccatgg tgttcatgtc tgtgaataac agcacatgat tttatacttc   177600

ctatacattc attgccatgg ttgtttttct atcttcttgt ttttgttgtt gttgttattt   177660

tcacatatct tgcaaagtat tttaggattg tatttctttt tagaattata aacttttaag   177720

agagagagat tatagagatt actacaagtt taatcaacag gttatcaatc tgaaaaggtt   177780

caaggttgca tgacttagaa tcataaaatt gagtgccaca taacagagta agcatttaaa   177840

atcaataatt ttggaaaagc atattatcac cagaagtcat accaaaattg atataagaaa   177900

atgtattaaa atttaggtga gaatttcaca ctaacaaaaa tgattctgaa agcattccta   177960

ttaagtcagg aaaaaaaaaa gagtgtgcct gtatcatccc tgtttttagt gttgttggcc   178020

aatgcaatta gataagaaaa cagagaggta catatataaa aacaatggag taaatgatcc   178080

ttaatataat gaccttcttc atataatgaa agaacttgtt catatattga aagagaatca   178140

actaaaaata aattcaatta gagttcaaaa ggtacaaatt ttaaattaca tgtgccaaca   178200

ctaataatta tcttatacat gaaaaaaatt agaaaatctg attcacaatt gcaataaaaa   178260

taaagtaaat tatctaataa taactttatc atatgagact tctgaagaaa actttaggat   178320

ataaaagaaa gctaaaataa ttgaaaggat tgtcatgtac ttagataagc ttctctcatt   178380

gtaattaaga ctttcaaatt tattaatcta taaattcaag gaaaatatca atgagtcttt   178440

ttatgtagtg tgggtaataa atagacaaaa acaatataag tctaaatgat tctaaattca   178500

tctggaagaa aattagggtg acaagaggtg gcttattctg caaaatatta agacatatag   178560

atgttaaata aaactgttca aatataaaag ctcagtgggt ttgaagagag tccaaattaa   178620

actttaatgt ataattacca atttactgtg tgaaaagatc acatgaatca aaatctaaag   178680

ttaaaaaaaa agattctagt aggaaatatg tggaaataga catataacca tatactctta   178740

tagtcctttc tatgcaaaac acaaatttgt aaagccaaaa aaaaaaatga agaagaaatg   178800

actgcacaaa aaaacaaaat attctttggg gaaaaaatca tcataaataa aaggttgaaa   178860

gacaaaaaat aggtgaaatg tttacataac agttaaggcc gagaaaggat caatacttta   178920

aatagaaaat tgttcttata aattaataag aatatagtaa aaatcccaat agacacatgg   178980

gcaaatacca aactaagcca aaaacagaag ttaaaaacaa ccaataagga tacaaaataa   179040

caaaacacaa ggaaaattgt ggattatttt cacaaaaaat gcaaataaat tacaatagta   179100

gatgttttca aatgtcatga aaattttttg gtaaaaaact ataaagaaga atggtagcac   179160

tcaatactgt tgaatgtgta aagtatgagc actatcatat actgccatta gaaatgttaa   179220

ttagtacagg ctttctggag ataggttcag ctatatattg tgtgtatata tatacacata   179280

cacacacata ctatgtatat agtatagagt atgtatatat gtatactata tatatacata   179340

ctctatacta tatatatagt atacgcatac tctatactat atatatagta tacgcatact   179400

ctatactata tatatagtat acgcatactc tatactatat atatagtata cgcatactct   179460

atactatata tatagtatac gcatactcta tactatatat atagtatacg catactctat   179520

actatatata tagtatacgc atactctata ctatatatag tatatgcata ctatatgcta   179580

tatagcgtat atgcatacta tatgctatat agagtatacg catactatat gctatatata   179640

catactatat agtatacata tactatgtac tgtatatacg tatacttagt atatgtatat   179700

gtatatgtat agtatatgta tatgtatagt atatgtatac tatatactgt atatagtata   179760

tatagtatgt gtatatatat agtatgtgtg tatatatagt gtgtgtatat atataaacat   179820

atatatactg ttgacccaag ttctattaac atattattaa aaagtactca tgcaattagg   179880

agaacatagc tatttagata ttcatttcag taacaaaaat ggaaacagta taaatgctag   179940

tcttcaattt gtggttattt tgagagaaca ttataccact ataataaatt atttcgttgt   180000

catttttatg aaactatctc catgacatat aaagtaaata aaataggtta caggctgggc   180060

actgtggctc acgcctataa tcccagcaca ttgggaggcc gaggtgggcg aaatcacttg   180120

aagtcagaag tttgagacca gcctggccaa caaggtgaaa accgtcccta ccaaaaacac   180180

aaaaattaac caggtgtggt ggcgcatgcc tgtagtccca gctactctgg aggctgaggc   180240

tggagaatca tttgatcccg ggatgcagag attgcagtag gccaagatca caccaccgca   180300

ctccagcttt ggcgacagag caagactctg tcttgaaaaa taaataaata ggttacaaaa   180360

aaagcttata taacatgaat acatttgttt gtgtgtgtac atgtgcttgc acagaaaaat   180420

gtctgaagtg atactcaaaa aaatattgat aatagttatt gttgacattt caggtgattt   180480

atattttctt tttagcattt aacggtattg cttgaatttt ctatgtgagt aggtatcatt   180540

cttaaaatgt aaaacactat tatggaggga aaaaatggcc catgaactta gtaaaaagga   180600

gaaaatgtca caatggtaat gttagtcatt tctctttgga atttcttaat ccttttttaa   180660

gtaattgcat tcagtataaa ataactgtct tggccgggca cggtggctca cgcctgtaat   180720

cccagcactt tgggaggccg aggcgggcgg atcacgaggt caggagatcg agaccatcct   180780

ggctaacaag gtgaaacccc gtctctacta aaaatacaaa aaattagccg ggcgtggtag   180840

cgggcgcctg tagtcccagc tactcgggag gctgaggcag gagaatggcg tgaacccggg   180900

aggcggagct tgcagtgagc cgagatcgcg ccactgcact ccagcctggg cgacagagcg   180960

agactccgtc tcaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aactgtcttg   181020

aattcataag aaatgagttg acagataaaa ctgtttagag tcatcatttc aggtagcata   181080

catctttaaa tattttattt ctattatttt cctccacata caggtatgtt tctagctgat   181140

ttgattgaaa cgtattttgt gtcccctacc ctgttccgag tgatccgtct tgccaggatt   181200

ggccgaatcc tacgtctagt caaaggagca aaggggatcc gcacgctgct ctttgctttg   181260

atgatgtccc ttcctgcgtt gtttaacatc ggcctcctgc tcttcctggt catgttcatc   181320

tacgccatct ttggaatgtc caactttgcc tatgttaaaa aggaagatgg aattaatgac   181380

atgttcaatt ttgagacctt tggcaacagt atgatttgcc tgttccaaat tacaacctct   181440

gctggctggg atggattgct agcacctatt cttaacagta agccacccga ctgtgaccca   181500

aaaaaagttc atcctggaag ttcagttgaa ggagactgtg gtaacccatc tgttggaata   181560

ttctactttg ttagttatat catcatatcc ttcctggttg tggtgaacat gtacattgca   181620

gtcatactgg agaattttag tgttgccact gaagaaagta ctgaacctct gagtgaggat   181680

gactttgaga tgttctatga ggtttgggag aagtttgatc ccgatgcgac ccagtttata   181740

gagttctcta aactctctga ttttgcagct gccctggatc ctcctcttct catagcaaaa   181800

cccaacaaag tccagctcat tgccatggat ctgcccatgg ttagtggtga ccggatccat   181860

tgtcttgaca tcttatttgc ttttacaaag cgtgttttgg gtgagagtgg ggagatggat   181920

tctcttcgtt cacagatgga agaaaggttc atgtctgcaa atccttccaa agtgtcctat   181980

gaacccatca caaccacact aaaacggaaa caagaggatg tgtctgctac tgtcattcag   182040

cgtgcttata gacgttaccg cttaaggcaa aatgtcaaaa atatatcaag tatatacata   182100

aaagatggag acagagatga tgatttactc aataaaaaag atatggcttt tgataatgtt   182160

aatgagaact caagtccaga aaaaacagat gccacttcat ccaccacctc tccaccttca   182220

tatgatagtg taacaaagcc agacaaagag aaatatgaac aagacagaac agaaaaggaa   182280

gacaaaggga aagacagcaa ggaaagcaaa aaatagagct tcatttttga tatattgttt   182340

acagcctgtg aaagtgattt atttgtgtta ataaaactct tttgaggaag tctatgccaa   182400

aatccttttt atcaaaatat tctcgaaggc agtgcagtca ctaactctga tttcctaaga   182460

aaggtgggca gcattagcag atggttattt ttgcactgat gattctttaa gaatcgtaag   182520

agaactctgt aggaattatt gattatagca tacaaaagtg attcagtttt ttggttttta   182580

ataaatcaga agaccatgta gaaaactttt acatctgcct tgtcatcttt tcacaggatt   182640

gtaattagtc ttgtttccca tgtaaataaa caacacacgc atacagaaaa atctattatt   182700

tatctattat ttggaaatca acaaaagtat ttgccttggc tttgcaatga aatgcttgat   182760

agaagtaatg gacattagtt atgaatgttt agttaaaatg cattattagg gagcttgact   182820

ttttatcaat gtacagaggt tattctatat tttgaggtgc ttaaatttat tctacattgc   182880

atcagaacca atttatatgt gcctataaaa tgccatggga ttaaaaatat atgtaggcta   182940

ttcatttcta caaatgtttt tcattcatct tgactcacat gccaacaagg ataagactta   183000

cctttagagt attgtgtttc atagcctttc ttctttcata tccctttttg ttcatagaat   183060

aaccacagaa cttgaaaaat tattctaagt acatattaca ctcctcaaaa aaaacaaaga   183120

taactgagaa aaaagttatt gacagaagtt ctatttgcta ttatttacat agcctaacat   183180

ttgactgtgc tgcccaaaat actgataata gtctcttaaa ctcttttgtc aaattttcct   183240

gctttcttat gcagtattgt ttagtcatcc tttcgctgta agcaaagttg atgaaatcct   183300

tcctgatatg cagttagttg tttgaccacg gtacatactt gagcagataa taacttgggc   183360

acagtattta ttgcatcact tgtatacaat cccgtgtttg gcaagctttc aaatcatgta   183420

atatgacaga ctttacacag atatgtgttt agtatgaata aaaaagcatt gaaataggga   183480

ttcttgccaa cttgctctct tgccaccaac ttactttcct aaattatgga agtaatcttt   183540

tttggatata cttcaatgta tacaatgagg aagatgtcac cttctcctta aaattctatg   183600

atgtgaaata tattttgcct caatcaacac agtaccatgg gcttctaatt tatcaagcac   183660

atattcattt tgcattagct gtagacatct agttttttga aaacacctat taatagtaat   183720

ttgaaaagaa ataaccataa tgcttttttt cgtgagttta tttcaggaat atgagatctt   183780

tcttctataa agttattcat gcacaggcaa aaattgagct acacaggtag aatgtagttt   183840

tacttagaag atttttgtgg gaggttttga agcaaatata taaaacaact ttcactaatt   183900

tgctttccat atttaaaaaa taataaatta catttatata ataaatgttt aaagcacata   183960

ttttttgttg ttctggcaat ttaaaaagaa agaggattta aacgtaccta tagaaacaaa   184020

gatttatggt taaagaatga gatcagaagt ctagaatgtt tttaaattgt gatatatttt   184080

acaacatccg ttattacttt gagacatttg tcctaatcta cgtataaaac tcaatctagg   184140

gctaaagatt ctttatacca tcttaggttc attcatctta ggctatttga accacttttt   184200

aatttaatat gaaagacacc atgcagtgtt ttccgagact acatagatca ttttatcaca   184260

tacctaccaa gcctgttgga aataggtttt gataatttaa gtagggacct atacaaaata   184320

tattacattt atcagatttt taaatacatt caattaagaa tttaacatca ccttaaattt   184380

gaattcaatc taccgttatt tcaaactcac aaatataact gcattatgaa tacttacata   184440

atgtagtaag acaagatgtt tgacaggttc gtgtgtaatt ttctattaat gtttttacat   184500

tgccttgttt ttatgtaaaa taaaaaatat gggcaactgg tttgttaaca acacaatttc   184560

ttcttagcat ttcaaaaata tatataaagt tgttcttttt cctatttcat gaactatgtt   184620

tttttttaaa ataacatggt taagttttat atatatttac gtttgtttca ggaatgtcta   184680

cttgtgactt tttatcaatt aaaaataata tttggaagaa agagcttatt aagtataagc   184740

ttgaagtaaa attagacctc tctttccatg tagattactg tttgtactga tggtttcacc   184800

cttcagaagg cactgtcata ttaatattta aattttataa tcgctgaact tattacaccc   184860

aacaatacag aaaggcagtt acactgaaga acttaactta gaataaaatg gaagcaaaca   184920

ggttttctaa aaactttttt aagtgaccag gtctcgctct gtcacccagg ctagagtgca   184980

atggcatgat catagctctc tgcagcctca actctgggct caagcaaccc tcctgcctca   185040

gcctcccaag tagctaagac tacaggtaca tgccaccatg cctggctaat atttaaattt   185100

ttgtagataa ggggtcttgc tatgttgccc aggctagtct caaactcctg gcttcaagtg   185160

ttcctactgt catgacctgc caacatgctg gggttacagg catgagccac catgccccaa   185220

acaggtttga acacaaatct ttcggatgaa aattagagaa cctaatttta gctttttgat   185280

agttacctag tttgcaaaag atttgggtga cttgtgagct gtttttaaat gctgattgtt   185340

gaacatcaca acccaaaata cttagcatga ttttatagag ttttgatagc tttattaaaa   185400

agagtgaaaa taaaatgcat atgtaaataa agcagttcta aatagctatt tcagagaaat   185460

gttaatagaa gtgctgaaag aagggccaac taaattagga tggccaggga attggcctgg   185520

gtttaggacc tatgtatgaa ggccaccaat tttttaaaaa tatctgtggt ttattatgtt   185580

attatcttct tgaggaaaac aatcaagaat tgcttcatga aaataaataa atagccatga   185640

atatcataaa gctgtttaca taggattctt tacaaatttc atagatctat gaatgctcaa   185700

aatgtttgag tttgccataa attatattgt agttatattg tagttatact tgagactgac   185760

acattgtaat ataatctaag aataaaagtt atacaaaata aaattatgtt tacacgtatt   185820

ttctgtttca gttagaataa ccataggtgg gtaaagtcag tggatatcta aataagttgc   185880

aacaactgat agctttttcc ttttcattga aaggacagct tcaaatgtcc tccataagaa   185940

gtgttcccgg gaaacaaaga caaggacaaa gaatctagag ttccaaagta atttcttgaa   186000

atccacatca aggtttgtgc aaagggagaa aattgagaca ggaagcaaaa atatgcaaac   186060

atctagccac acagcgatgt ctacattttt gtgtaatagc attaagaggt ggtgtagcat   186120

acataatggc taagagcttt ggttcatgga gactgcattg ttcctgtatg acacagaagt   186180

agcctggatt cttacatttt tagtagcaaa ttggttgtca tactaactac tattactact   186240

aatataaatt cttgattctg tattgtcatt gttctaattt ctttgtgtag cttgtctcat   186300

tctaccctta caaccacatg gagtattact ctttttctca ttttacagat gggaaagctg   186360

taccagctct taagaggtga tatagcatac ataatggcta agagcatggg ttctaagact   186420

agaactatat ttgtatccca gttaagccat gaccctatga gtttgctgaa tacattcttt   186480

aacctatatg ggcctcaact ttcttatcta taaaatgagg agaagagtac tacttcatta   186540

tgtggttgta atgatagaat gagacaagct tcatgaagaa attaaaacaa tgactgaaaa   186600

cacattgaaa atttatatta gtagtaagag tagttagtat ggcaattaat ttgctactaa   186660

aaatgtaaga acccaggcta cctctgtatc atacaggaac aatgcactct tcatgaatgt   186720

taaataatga caatattttc tctattttat atgggtaagt ataactatag tgcccaaaag   186780

agttttatgc acccattggt aggtagtaaa tatttagtga tgtggcatat acaccaaata   186840

tttcaaaatt tagctacttt tgagatttat gaattcaaac aacatattaa aatcaggaaa   186900

tatgcacatt tataaaggtc tagcttattt ccaaaaagtg gaggtggttc ttaccatttt   186960

tagctgagta attaatacaa ccctctactt tagctataag catcaagtcc tgttgatggt   187020

cattaggtaa gatattctaa aaataattgc catactaggc cattatttca acttttatgt   187080

tatcttaata gcatgtaaaa ggtgtaaaat agtccttggg acttttgtac tgatagttgc   187140

aatagccact ctgcaaaata gaattataat cactgaataa tactgtaatc catttcaaca   187200

taagtgattg tgatacatgc aaatttttta caacaacaaa gctaaattct ttcacattgt   187260

agataatgct atgccataac ccaagcaaaa tgagctgcag gatacatggt aatctctctc   187320

aagggaggga gaaattacat actagctaga gcagagggga ttttgctgca atagtatttg   187380

atgcacacag gaaatgaaac atgaataatt gatagttata aacaagcaat agagctcaca   187440

tgctacactt agcttgactc cctattactc tgcgagccat acctacatta ataattgatc   187500

tgtctgcgaa aaggtaattt gaagagattt atgagacatt ggtaataact gcatcattgc   187560

actttagctt gaatcttttt aaatatatct ttagaaacaa aagataaaag caatgcacaa   187620

taagtataca gaaaatgttc agagcttgtt aaaaattttg caaatctagt agaactgagc   187680

aaaagttatt cgtaagttgt aatatttgct ggcatgacct agtttttatt ttatttccta   187740

caaaacaata tgtcttcaag ttagttcagt catattcttt ctataaaaat ataattcttc   187800

tctaatatac catcataatt catttttatt tttagtgatg tgtaaaattt agaatttatg   187860

ggaaaattat atccagtgaa tattaagaat acactcccat taaattacta tttctaaata   187920

tgtgagaaca taatctggat ttgcatgtgc tgctttaaac aaatacattc ttttacttat   187980

ggctggccct tcatctgagg agcctccaga tttactctct ttaaatatct tgtgtcttct   188040

actctgtaca ttgacaatat gttaaaatgt gctttctcct gttcttaggc tactcttgag   188100

aactgctcat ttttatatga gaaagaatga tatcttgctc atataagaaa aggatataaa   188160

ccaactgtga tacactaatt ccttctaaca gaacagaaaa aataagtgga tggggttaca   188220

tgtgtcttta tacaaaacac agataactat acccaggctc ctgcctcaca aaaattgtga   188280

gataatacat ttgtattatt ttaagctgct aaatttgtga tcatttgtta caaaggatca   188340

aacacaaatg catgctcctg ttttccaatg taccatgtta aggtagaaat acagatgagc   188400

aacgctacta gaaaggttat tttatcaaac cacaatggct catacagact gtggaggtaa   188460

aaagagaggg acactggtga gacagtttgg cacactgatc tcgcccgcaa aagactgatg   188520

tagaaagcaa atgttaattg ttatcttatc aaaaatttaa aggaggagat tttcctccct   188580

gttgactatc ctaatcgtgt ttaccattca gtgcacctta ttcttggcaa agcaccttac   188640

aaatttttac ccagaagcca aagaaaatgg gcaatcttaa gtaattttct caaagtcaaa   188700

gagaatctga agtatacttg tcccactcat gcctttaaaa tgtaggccaa gagaatctac   188760

agcaaatgtc ttctaaaacg tttcatttgg aacataaaaa gtttctatgt caatacattt   188820

aaggaagggt gcattatata tttcactctt agagtaacat aattcacttt agcatgttac   188880

atgcttgcag aagacatgag actcaggagt cagagataat aatagattat tacttaaagc   188940

aatagcagga gccagagtat tatcattttt gtgttggtct tagaaagctg gggctgtcat   189000

aataatatac catagactgg gtggctagaa caacagaaat ttatttctaa cagttcccga   189060

ggctgaggag tccaagatta aggcgccagc caatttcgtt ccccagtgag ggctcatttc   189120

ctggctggca gagggcagca ttctcactgt gtcttcaaat ggaggaggca gtgagctctg   189180

gtctctcttc ttttttctat aggaatacta atctcatggt ggaagatata tatatatata   189240

tatatatata tatgtatata tatatgtgtg tatatatata tatatacata tatatatatg   189300

tgtgtgtata tatatatata tatatatata tatatatata tgcattcagt cctccatatc   189360

catggtttct gatctgtgga ttcaaccaat tctggatcag aaatagttgg ggaaaaaatc   189420

cacaaagccc caaaaggcaa aacttgaatt ttccatatgc tgagtactac attgaatcca   189480

tacaaatgaa gtgatgtgta ggtaatttta aactatatag gaggatgtgt gtaggttata   189540

agcaaacact atgccatttg tataagagat ttgagcatct gtggattttg gtattctcag   189600

ggagtccaga agccaatccc cagcagatac taagggacaa ctgtatatca tggtaaataa   189660

attacatctt ccttctcatt gattagtacc accattcatc cagttttcca aactaatcct   189720

cttcattaac cctccgcatt tattcaccaa gaccagttca ttctaccacc taatgtaatg   189780

taaatacatc aacttctctt aatttccact gtcaacacct aatccaatcc attaccacct   189840

ttaacctctt tataagacaa tgtaataacc tacttgtttt atcttactaa atccattctt   189900

gcctcacttc caaatctatt ctcagtacag tagccagagt ggattttatg aggttgtgac   189960

atttccctgc ttaaaatttt gggtcatttt ccggcataaa attctgtaat atttctccat   190020

tattatgatg ataaattcta aaatcctcag caaagatttt acaaactcta tactattact   190080

gtctacaagt tctacaagct ttccagccct acaccatgtc agcctcactg ctcttatctt   190140

ccctctttcc ctatcttaat ctgtgtgctt cagcctcaat agttttcttt ctgtttgcag   190200

gatcttctca acaaaagtat agtgtattct tacattctta tacagtgcca gtgctttctg   190260

gcctgagaga gactatacat gtctttcaca tggtaagttg agtggatgtt tgaaactgtc   190320

ccactgctca caaaataaaa ttagtataga aaactggcat ttttgaagga ctaagttaaa   190380

agtgtttttc ctctatagct ttaacaaagt agaaaaaaaa cagagataat gtcaagtagg   190440

aaataaagac tgaaaaatga aaactttcat atacattcta cattaaaatc agacatttat   190500

ttctctaagg cctgagtttc tcaatattgg caatcttgat atttgagctg gataattctt   190560

tgttgtgagt ggctgtcctg tgcatggtgg gatgtttagc acgatcactg gtctctaacc   190620

tctagatatc aataaacatt cctaattcca cagttatgac aaataaaaat gtccccatct   190680

ttgctaaatg ttctcagggg gacaaaatct tccccagttg acaacgactg atctctgaca   190740

atgtctataa aagtatgaat catggataac cgacattacc ttagctatta gttt         190794


<210> 5305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5305
ggaaataaag actgaaaaat                                                   20


<210> 5306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5306
tagctttaac aaagtagaaa                                                   20


<210> 5307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5307
cacaaaataa aattagtata                                                   20


<210> 5308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5308
atccacaaag ccccaaaagg                                                   20


<210> 5309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5309
aatctacagc aaatgtcttc                                                   20


<210> 5310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5310
gggttacatg tgtctttata                                                   20


<210> 5311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5311
agtttttatt ttatttccta                                                   20


<210> 5312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5312
aagaaattaa aacaatgact                                                   20


<210> 5313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5313
gacaagcttc atgaagaaat                                                   20


<210> 5314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5314
tatgttatta tcttcttgag                                                   20


<210> 5315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5315
tggaagcaaa caggttttct                                                   20


<210> 5316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5316
catttgtcct aatctacgta                                                   20


<210> 5317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5317
gaggttttga agcaaatata                                                   20


<210> 5318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5318
ctgtagacat ctagtttttt                                                   20


<210> 5319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5319
tacatattac actcctcaaa                                                   20


<210> 5320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5320
ataaatcaga agaccatgta                                                   20


<210> 5321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5321
aagtgattta tttgtgttaa                                                   20


<210> 5322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5322
aatgagaact caagtccaga                                                   20


<210> 5323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5323
tgaacccatc acaaccacac                                                   20


<210> 5324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5324
ggatcctcct cttctcatag                                                   20


<210> 5325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5325
ataagaaatg agttgacaga                                                   20


<210> 5326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5326
aaaaaaaaaa aaaaaaaaaa                                                   20


<210> 5327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5327
taggtatcat tcttaaaatg                                                   20


<210> 5328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5328
aggtgaaaac cgtccctacc                                                   20


<210> 5329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5329
accagcctgg ccaacaaggt                                                   20


<210> 5330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5330
gtcatgaaaa ttttttggta                                                   20


<210> 5331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5331
ccaataagga tacaaaataa                                                   20


<210> 5332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5332
ctaagccaaa aacagaagtt                                                   20


<210> 5333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5333
ggcaaatacc aaactaagcc                                                   20


<210> 5334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5334
aagaagaaat gactgcacaa                                                   20


<210> 5335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5335
ctcttatagt cctttctatg                                                   20


<210> 5336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5336
taagacatat agatgttaaa                                                   20


<210> 5337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5337
agtgtgggta ataaatagac                                                   20


<210> 5338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5338
tatcatatga gacttctgaa                                                   20


<210> 5339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5339
aaacagagag gtacatatat                                                   20


<210> 5340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5340
tggccaatgc aattagataa                                                   20


<210> 5341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5341
ttatatatag ctgtgtcttg                                                   20


<210> 5342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5342
agtttccaat attacctttg                                                   20


<210> 5343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5343
aatgaaaaaa tcctaaaaag                                                   20


<210> 5344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5344
tttcactgga gaatgtgtgc                                                   20


<210> 5345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5345
aaagataaaa gtacatagtt                                                   20


<210> 5346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5346
taagttctag ggtacatgtg                                                   20


<210> 5347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5347
agatttaggc ttttccagtc                                                   20


<210> 5348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5348
gtagaatata cataaatctg                                                   20


<210> 5349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5349
acaacaacaa caacaacaac                                                   20


<210> 5350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5350
cctcagagca agactccatc                                                   20


<210> 5351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5351
atcacttgag gccaggagtt                                                   20


<210> 5352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5352
taaatagagg aaagctgaat                                                   20


<210> 5353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5353
caaccaggat atcattaggg                                                   20


<210> 5354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5354
ctaaataagc tataggaaaa                                                   20


<210> 5355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5355
aaggcctaaa taagctatag                                                   20


<210> 5356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5356
atgtagattg taacacagaa                                                   20


<210> 5357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5357
aaattagttt ttaataatca                                                   20


<210> 5358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5358
ttgaaatgcc tgtttgattt                                                   20


<210> 5359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5359
acacaatgtc acaaaggaca                                                   20


<210> 5360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5360
agattcagcc aatgctgatt                                                   20


<210> 5361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5361
ttcaacttct taacagttgt                                                   20


<210> 5362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5362
ttgtctattt tatctttcga                                                   20


<210> 5363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5363
aagttgggtt ctacaaaatg                                                   20


<210> 5364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5364
atcgtttttt gtacttgaga                                                   20


<210> 5365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5365
ctgagagtgc tcaggcagtt                                                   20


<210> 5366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5366
agaaccacag ggagcggctg                                                   20


<210> 5367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5367
tttaatcttc ttaaatttgt                                                   20


<210> 5368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5368
gtttcatgtc atcatgaaca                                                   20


<210> 5369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5369
tttcgatttt atcttttcaa                                                   20


<210> 5370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5370
ggatttttta ctatttctgt                                                   20


<210> 5371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5371
attgcagcaa aagtaatggt                                                   20


<210> 5372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5372
ttgtgcttat ttatggggta                                                   20


<210> 5373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5373
actcatttat tccaaagaaa                                                   20


<210> 5374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5374
ttctttccac tcttccctga                                                   20


<210> 5375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5375
gttactgatt tagaagcatc                                                   20


<210> 5376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5376
aagagcagta tgagcataaa                                                   20


<210> 5377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5377
gaataggaaa tatgttccat                                                   20


<210> 5378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5378
ataatacaaa cctgagggct                                                   20


<210> 5379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5379
aaatcaatac actatttatt                                                   20


<210> 5380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5380
atcttattca tttttgcaca                                                   20


<210> 5381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5381
cttttactgt ttttacagtt                                                   20


<210> 5382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5382
ttgtggtaac attaaacaga                                                   20


<210> 5383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5383
aatggacatg ttgaatacag                                                   20


<210> 5384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5384
ataaaatact gtgtggtttt                                                   20


<210> 5385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5385
ttagtcaaaa tgtgcgatgg                                                   20


<210> 5386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5386
tagagtaata ataataaatt                                                   20


<210> 5387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5387
aaataaagaa aggattaaag                                                   20


<210> 5388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5388
ccacaggaat tgccctggat                                                   20


<210> 5389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5389
gtgtcaggtg ttgtgatata                                                   20


<210> 5390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5390
tcattactca cattttttag                                                   20


<210> 5391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5391
tctatcacaa ctttccccta                                                   20


<210> 5392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5392
tataactaaa ttatatttga                                                   20


<210> 5393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5393
tttaatgggg tttaaaatat                                                   20


<210> 5394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5394
attgtgattt ttctcccatg                                                   20


<210> 5395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5395
ctacatgagg atgagcactt                                                   20


<210> 5396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5396
gacaaacatt caaaccacag                                                   20


<210> 5397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5397
tatgcatata ttccgtgtca                                                   20


<210> 5398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5398
tgaaggatgg tctcaaaact                                                   20


<210> 5399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5399
ttgttcttga aggatggtct                                                   20


<210> 5400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5400
cacacaacat attaaatgtt                                                   20


<210> 5401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5401
atctcagacc caattatagg                                                   20


<210> 5402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5402
aatgtcattc ttgttaagaa                                                   20


<210> 5403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5403
attcttactg tgtgttgtga                                                   20


<210> 5404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5404
aaatggatag catatggtta                                                   20


<210> 5405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5405
tattgatacc aacagtttcc                                                   20


<210> 5406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5406
ctcagaaaga agagtataca                                                   20


<210> 5407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5407
aattccttgt tcaaaatgtc                                                   20


<210> 5408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5408
tcttgtgtgt tataaaaagg                                                   20


<210> 5409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5409
catcagatat tcaggaaatt                                                   20


<210> 5410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5410
tatacaatcg taaggaggca                                                   20


<210> 5411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5411
gtttcctcag aagctataga                                                   20


<210> 5412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5412
ttactggcaa tatcagtttg                                                   20


<210> 5413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5413
aaaatctggt ggaacatcag                                                   20


<210> 5414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5414
aactaactaa caactattta                                                   20


<210> 5415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5415
gacaagaata cattgtaagc                                                   20


<210> 5416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5416
tctgttttta tctacctaac                                                   20


<210> 5417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5417
tactcttttt gtgtgacctc                                                   20


<210> 5418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5418
aagcaattat ttgcaaatca                                                   20


<210> 5419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5419
gctctgttta tcacttctta                                                   20


<210> 5420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5420
attatctgaa gttgttactt                                                   20


<210> 5421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5421
aaacatgaaa agattcatta                                                   20


<210> 5422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5422
cataaaatat acatgataac                                                   20


<210> 5423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5423
cttagaaact tccagagaga                                                   20


<210> 5424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5424
cttgggatat acctttgcac                                                   20


<210> 5425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5425
tttttactga agataaatgt                                                   20


<210> 5426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5426
ggattgaaca ttgggtgctt                                                   20


<210> 5427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5427
gtctccaaca aacaaacaaa                                                   20


<210> 5428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5428
ggatatgcat aacatttggg                                                   20


<210> 5429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5429
gagggagatg gagctgtgaa                                                   20


<210> 5430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5430
caaaccaaaa aatgacttca                                                   20


<210> 5431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5431
ttgaaaagca aaaacaaaaa                                                   20


<210> 5432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5432
tttttttgaa aagcaaaaac                                                   20


<210> 5433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5433
tttttttttt tttgaaaagc                                                   20


<210> 5434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5434
tcatcaccat ctgttgtttg                                                   20


<210> 5435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5435
aatctactca ctaactctca                                                   20


<210> 5436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5436
ggtcattggc attttgattt                                                   20


<210> 5437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5437
ctcataaagc tctgggtgag                                                   20


<210> 5438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5438
tatgctgctt tactccttta                                                   20


<210> 5439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5439
attttaaaac ttatatattt                                                   20


<210> 5440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5440
tcctggatta atctgtattt                                                   20


<210> 5441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5441
aggtcaggaa ttgaagccat                                                   20


<210> 5442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5442
ttcctctcac tgctttacct                                                   20


<210> 5443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5443
aagttgttac cagctcagag                                                   20


<210> 5444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5444
aatgctctct taaacagtga                                                   20


<210> 5445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5445
aattgaccat taaaaaaaca                                                   20


<210> 5446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5446
tgaattcaat tgaccattaa                                                   20


<210> 5447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5447
aatacttaat gcattcccaa                                                   20


<210> 5448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5448
tatatttcac cgcaggaaaa                                                   20


<210> 5449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5449
atgatcttcc ttgtatagta                                                   20


<210> 5450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5450
ttcatttcca aaattacatg                                                   20


<210> 5451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5451
ctatatcact ttcatatttt                                                   20


<210> 5452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5452
agcttcaagg caatcaaagg                                                   20


<210> 5453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5453
tctactcaag cagtatagta                                                   20


<210> 5454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5454
acaattatag atattgaccg                                                   20


<210> 5455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5455
tattaatgac ctccaatttt                                                   20


<210> 5456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5456
taaattagtg gaagtaacat                                                   20


<210> 5457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5457
aatggtcatc ctcttaagaa                                                   20


<210> 5458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5458
attatctata taggtataga                                                   20


<210> 5459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5459
ttagaggcaa tattctcata                                                   20


<210> 5460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5460
ctattgtgca atgatgaaag                                                   20


<210> 5461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5461
cacatttaaa ttaagtagat                                                   20


<210> 5462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5462
attgaagcta catttaattt                                                   20


<210> 5463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5463
tcttgcatgc tgttcagcta                                                   20


<210> 5464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5464
gtatatgact ttaaacattt                                                   20


<210> 5465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5465
atttaaggaa aaatagaatg                                                   20


<210> 5466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5466
ttggatttgt ttacgtgcct                                                   20


<210> 5467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5467
agtcccccaa aaaccacact                                                   20


<210> 5468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5468
ctataaatat tgagtccccc                                                   20


<210> 5469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5469
tccaaccatt tttaatctgc                                                   20


<210> 5470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5470
atattttaag ttaaataata                                                   20


<210> 5471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5471
catattgtat aaaattacca                                                   20


<210> 5472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5472
cccacttgcc tgaggaaggg                                                   20


<210> 5473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5473
aacattctgt tttcatattt                                                   20


<210> 5474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5474
acattcattc ttctctaggt                                                   20


<210> 5475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5475
ttcccttctt tattgaaaag                                                   20


<210> 5476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5476
ggtgtttaaa tttgtttctt                                                   20


<210> 5477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5477
acaaccctct ggagtagttc                                                   20


<210> 5478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5478
cggctgttgt aacaaattag                                                   20


<210> 5479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5479
aaataaccaa agagatgagt                                                   20


<210> 5480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5480
caaatcaaaa tattttacag                                                   20


<210> 5481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5481
tccctctctt ctccctaccc                                                   20


<210> 5482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5482
ctgcattttg agcaagggga                                                   20


<210> 5483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5483
aacaactcaa caacgacaaa                                                   20


<210> 5484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5484
tctgataatg ggttaatatc                                                   20


<210> 5485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5485
taggcaagga tttttttgga                                                   20


<210> 5486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5486
cacaactatt agagaagaaa                                                   20


<210> 5487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5487
gactacttaa atgtaagact                                                   20


<210> 5488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5488
caaacagaat gatactgaca                                                   20


<210> 5489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5489
ggcttcacac taactgactt                                                   20


<210> 5490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5490
aggtgaaata tatttacaat                                                   20


<210> 5491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5491
atatcaacag aatgaaacat                                                   20


<210> 5492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5492
gactgtatca tgaagaaatg                                                   20


<210> 5493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5493
aatcatactc caacaaattg                                                   20


<210> 5494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5494
taagaccttg agcaatttac                                                   20


<210> 5495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5495
attaagctgt ggtcaactat                                                   20


<210> 5496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5496
ctctttgtcc atttgaaaca                                                   20


<210> 5497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5497
gcagacagtt gctctcagaa                                                   20


<210> 5498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5498
aagtaatact cccaaaattt                                                   20


<210> 5499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5499
aaatggcaca atgtttacca                                                   20


<210> 5500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5500
tacataagat taaattaaat                                                   20


<210> 5501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5501
atgaatttat agtggacttg                                                   20


<210> 5502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5502
cattgagaac aggaactctt                                                   20


<210> 5503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5503
tctctctctt ctttttttta                                                   20


<210> 5504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5504
aagatctgaa tactaagaag                                                   20


<210> 5505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5505
aaaaataatt aactcagaaa                                                   20


<210> 5506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5506
ttcctttttt gtttcctgga                                                   20


<210> 5507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5507
ttaggtctta cttcgatttt                                                   20


<210> 5508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5508
atcttcacca atattcctat                                                   20


<210> 5509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5509
gttaaggacc ataggtttag                                                   20


<210> 5510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5510
ggcaatatag atttatagta                                                   20


<210> 5511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5511
tattatttag ggtggaagac                                                   20


<210> 5512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5512
ttgggaaagg tataacttgt                                                   20


<210> 5513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5513
tcttccttat actgattagt                                                   20


<210> 5514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5514
ttgtctgatc ttaacaatat                                                   20


<210> 5515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5515
aagatcaaat tgttatcccc                                                   20


<210> 5516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5516
gacaaatgca cttaaagaac                                                   20


<210> 5517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5517
tttggttttg cattattttt                                                   20


<210> 5518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5518
ctttgcagct gaaatggtat                                                   20


<210> 5519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5519
ctgttttcta atattaacag                                                   20


<210> 5520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5520
gacttaatga aacaagcttt                                                   20


<210> 5521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5521
atcatcaaca tcattgtcat                                                   20


<210> 5522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5522
acacacctca catattttca                                                   20


<210> 5523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5523
gaaaaatatg catattggtg                                                   20


<210> 5524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5524
cttattgttg tcatgggact                                                   20


<210> 5525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5525
atttaatagt aattgatgca                                                   20


<210> 5526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5526
actttgcaaa atgaaaaaaa                                                   20


<210> 5527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5527
ttatccccat tttaccaata                                                   20


<210> 5528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5528
gtttgacaga ctatagcaca                                                   20


<210> 5529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5529
gcacaatata tggtttatat                                                   20


<210> 5530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5530
aaatcctaaa gtgaaaacta                                                   20


<210> 5531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5531
atcacaataa atcctaaagt                                                   20


<210> 5532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5532
gacacaaaca aacataaaag                                                   20


<210> 5533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5533
ttcatctgga gtctatgaat                                                   20


<210> 5534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5534
tttgtaatgc ttcattggtt                                                   20


<210> 5535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5535
tcattggtat gattttaggt                                                   20


<210> 5536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5536
cattctgatc attgtgtaaa                                                   20


<210> 5537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5537
gctttatttc aacctgagac                                                   20


<210> 5538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5538
tacattccaa aattaccttg                                                   20


<210> 5539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5539
aattttttag tgtttataaa                                                   20


<210> 5540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5540
tgtcacaagg atttttaaga                                                   20


<210> 5541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5541
actcttctat ggggtatgac                                                   20


<210> 5542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5542
tagacgctgc gtgctgctgg                                                   20


<210> 5543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5543
aaattgaaat aatttactaa                                                   20


<210> 5544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5544
gtttaatttt cctctaatcc                                                   20


<210> 5545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5545
agcaaactaa aacaggaaca                                                   20


<210> 5546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5546
aaccatcatt ctcagcaaac                                                   20


<210> 5547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5547
gccattagag aaatgcaatt                                                   20


<210> 5548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5548
tacctaatgc atgcaggtct                                                   20


<210> 5549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5549
agcaaactaa tacaggaaga                                                   20


<210> 5550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5550
gatcattaag aaacgcaaat                                                   20


<210> 5551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5551
agaagacatt tatgcggcca                                                   20


<210> 5552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5552
taatgaccca agattactgg                                                   20


<210> 5553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5553
tactgaacca agaactatca                                                   20


<210> 5554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5554
atttatttaa tggcatcagg                                                   20


<210> 5555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5555
aatttcaggt cttctttctg                                                   20


<210> 5556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5556
ggtagaaaat gttacttcta                                                   20


<210> 5557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5557
taaacataaa ggaggtctca                                                   20


<210> 5558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5558
tgaaaagtaa gataatttta                                                   20


<210> 5559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5559
ttaatcttga aaattaattt                                                   20


<210> 5560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5560
tttaatagag aaagttttga                                                   20


<210> 5561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5561
atactgtggt tatattgggc                                                   20


<210> 5562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5562
cactgtctca cctcctgctg                                                   20


<210> 5563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5563
aaataatgaa gccaagagaa                                                   20


<210> 5564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5564
ggtatgggtt taaagaatgg                                                   20


<210> 5565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5565
agaaaaaggg agtgacgcac                                                   20


<210> 5566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5566
aaaaatagaa gccttaacaa                                                   20


<210> 5567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5567
tattaggttg aaataatgct                                                   20


<210> 5568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5568
aaccatttgc tgtaatatat                                                   20


<210> 5569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5569
ttttgaaaga aagacataaa                                                   20


<210> 5570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5570
ttcagagttc tccgagcatt                                                   20


<210> 5571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5571
ttcagagtat tgagagcttt                                                   20


<210> 5572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5572
catctgctac ctgctgctaa                                                   20


<210> 5573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5573
aaacctataa gaagcacaca                                                   20


<210> 5574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5574
agttcttgtt taaaaatgaa                                                   20


<210> 5575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5575
ttcatagtat tgaacaaagg                                                   20


<210> 5576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5576
aggaaaataa aaggacacct                                                   20


<210> 5577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5577
gaatggcagg ggaggcctca                                                   20


<210> 5578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5578
tctaggaagt tccttgaata                                                   20


<210> 5579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5579
tcagagcttt gtccatttca                                                   20


<210> 5580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5580
tattacataa gtttagttgg                                                   20


<210> 5581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5581
acacatgaat gataagaaaa                                                   20


<210> 5582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5582
agtgaacaca tgaatgataa                                                   20


<210> 5583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5583
tatttttcac tacattcttt                                                   20


<210> 5584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5584
cagttgaatg tagaatctac                                                   20


<210> 5585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5585
aaactaaatg cctgactaat                                                   20


<210> 5586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5586
tgtggatgcc ttccactttt                                                   20


<210> 5587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5587
attttctttc ttctggatag                                                   20


<210> 5588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5588
agtgggtaag atagtaatga                                                   20


<210> 5589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5589
catagatgga taagcataga                                                   20


<210> 5590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5590
tatgtatgta tttttcattt                                                   20


<210> 5591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5591
ataggaagat tgatattgtt                                                   20


<210> 5592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5592
ttttggaaaa cagcagataa                                                   20


<210> 5593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5593
tttaaaacag tagtattttg                                                   20


<210> 5594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5594
aacataagtg aaagggattt                                                   20


<210> 5595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5595
gacatgctta tgctcttccc                                                   20


<210> 5596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5596
ttttctctcc ttttgaataa                                                   20


<210> 5597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5597
cttcaaacca aacaaaatcc                                                   20


<210> 5598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5598
aagtaaatat taaaacattg                                                   20


<210> 5599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5599
gagaattaaa aagtaaatat                                                   20


<210> 5600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5600
gagggatgag tgagtatgag                                                   20


<210> 5601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5601
gaatacgtgt tcattatgtg                                                   20


<210> 5602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5602
taagtagtga atccagtatt                                                   20


<210> 5603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5603
gcaagtcttc atataaagtt                                                   20


<210> 5604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5604
taccaggcac acagagtctc                                                   20


<210> 5605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5605
agaggctcag tgatggaatg                                                   20


<210> 5606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5606
ggcgcatttg tcacaattaa                                                   20


<210> 5607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5607
cccaggcatg attactttaa                                                   20


<210> 5608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5608
agactagggg aagagtaaga                                                   20


<210> 5609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5609
gtcagggact acaaaggcta                                                   20


<210> 5610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5610
catgtaacca atactgggat                                                   20


<210> 5611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5611
ctgggtgatg aaataagctg                                                   20


<210> 5612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5612
aagtgagaca catagagggg                                                   20


<210> 5613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5613
tttcagaaaa agaagttttt                                                   20


<210> 5614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5614
ctatatagtt ttgaaaacca                                                   20


<210> 5615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5615
attttaacct atatagtttt                                                   20


<210> 5616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5616
ggttgctaag catgggaatg                                                   20


<210> 5617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5617
gtacaatatt caattttcaa                                                   20


<210> 5618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5618
aatcatagtg cttagtaaat                                                   20


<210> 5619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5619
gaagtggaat agtttcgtcc                                                   20


<210> 5620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5620
ttgtataagc cacagatcca                                                   20


<210> 5621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5621
ccattaccaa aaacaagttg                                                   20


<210> 5622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5622
aaaattttca tgccattacc                                                   20


<210> 5623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5623
gaaatgcttt aatcacttag                                                   20


<210> 5624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5624
acatctgtga tttcattttt                                                   20


<210> 5625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5625
taagattaag actgttctgt                                                   20


<210> 5626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5626
aattttataa gtcaactctg                                                   20


<210> 5627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5627
tctaatcctg aaaaataaaa                                                   20


<210> 5628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5628
tagctaatat tgaaaatggt                                                   20


<210> 5629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5629
tggatgtgca ttaaacaaag                                                   20


<210> 5630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5630
taggaaataa tgacaagaaa                                                   20


<210> 5631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5631
ctctcagaag atatagaact                                                   20


<210> 5632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5632
acactggaat gattacaact                                                   20


<210> 5633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5633
tttatgtaca cgtctttctt                                                   20


<210> 5634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5634
agctcacaat aaaaaattta                                                   20


<210> 5635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5635
tgtcaggtca cgaaagaaaa                                                   20


<210> 5636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5636
atttctgcat tttaaagttt                                                   20


<210> 5637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5637
tttattgggg tgaaagagaa                                                   20


<210> 5638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5638
taaaatggca tgttttgaaa                                                   20


<210> 5639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5639
agtagtagta gttgagaaag                                                   20


<210> 5640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5640
gcctgatttt taaaaaattc                                                   20


<210> 5641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5641
aaaaaagaaa gagaaagaaa                                                   20


<210> 5642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5642
ccatttctat aaaaaataga                                                   20


<210> 5643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5643
ttggctaaac tagtgccttt                                                   20


<210> 5644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5644
tatcctagta ttcttaaggt                                                   20


<210> 5645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5645
ttattctgca agtatgctta                                                   20


<210> 5646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5646
aacacttaat tataaggatg                                                   20


<210> 5647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5647
ctctaatggt ttaatcttta                                                   20


<210> 5648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5648
ctcaatgcac tctatgtgct                                                   20


<210> 5649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5649
tgttgaaaga atgctagttt                                                   20


<210> 5650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5650
aatctataat ttttttccta                                                   20


<210> 5651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5651
cttctgtttt ctttttgaaa                                                   20


<210> 5652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5652
tctagtattt tgtatcaatc                                                   20


<210> 5653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5653
gttatcacat gcaacaagaa                                                   20


<210> 5654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5654
aggatcacta aaaggagctt                                                   20


<210> 5655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5655
aaaagaggcg gatataagct                                                   20


<210> 5656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5656
aacaatttaa atgcttttct                                                   20


<210> 5657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5657
cccagggtga ttttctgcat                                                   20


<210> 5658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5658
aagaaaagta gttgtaggtt                                                   20


<210> 5659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5659
ggaagtacac agtagattag                                                   20


<210> 5660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5660
ctaattcctc ttccccaaat                                                   20


<210> 5661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5661
gtcgccaaat cagatttttt                                                   20


<210> 5662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5662
tgagcttcat ggtaattatt                                                   20


<210> 5663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5663
gaatgcatac aacaagcatg                                                   20


<210> 5664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5664
gaaaaaatta acccattgga                                                   20


<210> 5665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5665
cttttaaatc ttggtttaga                                                   20


<210> 5666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5666
aataagaaag aaattaaaaa                                                   20


<210> 5667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5667
ggctgtcagc atcaggttag                                                   20


<210> 5668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5668
ttaagttctg ctgtgaactt                                                   20


<210> 5669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5669
tgtatctgtg cctaggtttc                                                   20


<210> 5670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5670
acgaaattca cattttagat                                                   20


<210> 5671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5671
atatatttct attcattttt                                                   20


<210> 5672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5672
taaaactgcc ctcccaatgg                                                   20


<210> 5673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5673
ccagaaatat gtcatgaaaa                                                   20


<210> 5674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5674
aagactccag ggactgtgtg                                                   20


<210> 5675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5675
aatagatgta tacatgctga                                                   20


<210> 5676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5676
agagtaggtt aaaaaaagaa                                                   20


<210> 5677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5677
tgatgaaata agatgtagaa                                                   20


<210> 5678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5678
atattttatt atggcaaatt                                                   20


<210> 5679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5679
accagcctgg ccaacatggt                                                   20


<210> 5680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5680
gttaagagtt cctaaattaa                                                   20


<210> 5681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5681
taccataaac caaaagaaac                                                   20


<210> 5682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5682
aattattttc taagataata                                                   20


<210> 5683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5683
aatatctcac atatgcatgt                                                   20


<210> 5684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5684
aaaccacaaa actgctagaa                                                   20


<210> 5685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5685
ttaaaataac atacaaacca                                                   20


<210> 5686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5686
agactttatg aattttttat                                                   20


<210> 5687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5687
cactgtggta ggcactttac                                                   20


<210> 5688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5688
cataaacatg tttggcaaga                                                   20


<210> 5689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5689
gagcattttc atttttttaa                                                   20


<210> 5690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5690
agataaagca aatgtttagg                                                   20


<210> 5691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5691
tttcagaaga gtttgttacc                                                   20


<210> 5692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5692
tttttctttt ataccagtat                                                   20


<210> 5693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5693
acattttcat cattccaaac                                                   20


<210> 5694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5694
tctttctgcc ttacggatct                                                   20


<210> 5695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5695
tataaatgac tactgcctag                                                   20


<210> 5696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5696
ctttctggac atgggtaaca                                                   20


<210> 5697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5697
atgtatttaa ggagaagcaa                                                   20


<210> 5698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5698
gaagaatcat tctagtcaca                                                   20


<210> 5699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5699
gtagagacat gaagtaaatg                                                   20


<210> 5700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5700
agatatgctg tgaaaaacaa                                                   20


<210> 5701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5701
gtaccataag atatgctgtg                                                   20


<210> 5702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5702
aggtagactg gcagataaga                                                   20


<210> 5703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5703
tgaaataagt aaagggacac                                                   20


<210> 5704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5704
attcacaata gcaaaaatat                                                   20


<210> 5705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5705
gatactgtac tttgggatat                                                   20


<210> 5706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5706
agggttttaa aacagttttg                                                   20


<210> 5707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5707
aagttgactt ttaagggttt                                                   20


<210> 5708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5708
atctctacta aaaaaaatac                                                   20


<210> 5709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5709
catattttgt tttaacatta                                                   20


<210> 5710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5710
tcatgtaatt acagctaata                                                   20


<210> 5711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5711
acatcgtaat ttgttttttc                                                   20


<210> 5712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5712
ttcaaatcca tgcagatgag                                                   20


<210> 5713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5713
tgcattaaaa tataagtatt                                                   20


<210> 5714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5714
tatcttttta gttctataga                                                   20


<210> 5715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5715
gctcctgccc aggtcgtggc                                                   20


<210> 5716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5716
taataattta tgactttccc                                                   20


<210> 5717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5717
ttagactagc ttatcaacaa                                                   20


<210> 5718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5718
acatatatat aaagaaaaca                                                   20


<210> 5719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5719
tatatataca tatatataaa                                                   20


<210> 5720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5720
ataggatatc ctggagaagg                                                   20


<210> 5721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5721
agctatgaaa agccatggag                                                   20


<210> 5722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5722
gaggctttac gcataattgc                                                   20


<210> 5723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5723
gatgttcacc caaaggactt                                                   20


<210> 5724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5724
gacagtgtag cagtttcttt                                                   20


<210> 5725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5725
caaaatatac aaataaagct                                                   20


<210> 5726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5726
attaaaaact tctgctctgc                                                   20


<210> 5727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5727
aggtgaactg cattaaaatt                                                   20


<210> 5728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5728
agggctgcca aaagagcaag                                                   20


<210> 5729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5729
ctaatcctat ttaattagag                                                   20


<210> 5730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5730
actttttagc tatgtataca                                                   20


<210> 5731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5731
agcatctact acatgcaaga                                                   20


<210> 5732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5732
cacagaaagc acattatcag                                                   20


<210> 5733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5733
gataatgttg cccaatgact                                                   20


<210> 5734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5734
attgcagaat gctgtcaagc                                                   20


<210> 5735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5735
ctttgttaaa gctatagagg                                                   20


<210> 5736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5736
gaagatcctg caaacagaaa                                                   20


<210> 5737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5737
caagaatgga tttagtaaga                                                   20


<210> 5738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5738
taatgaagag gattagtttg                                                   20


<210> 5739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5739
taccttaaca tggtacattg                                                   20


<210> 5740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5740
tgttttgtag gaaataaaat                                                   20


<210> 5741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5741
actacctacc aatgggtgca                                                   20


<210> 5742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5742
actcttttta ataaagctat                                                   20


<210> 5743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5743
atgttcaaca atcagcattt                                                   20


<210> 5744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5744
gtcacttaaa aaagttttta                                                   20


<210> 5745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5745
gaaacaaacg taaatatata                                                   20


<210> 5746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5746
ttaaccatgt tattttaaaa                                                   20


<210> 5747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5747
ccatattttt tattttacat                                                   20


<210> 5748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5748
acataaaaac aaggcaatgt                                                   20


<210> 5749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5749
taggtcccta cttaaattat                                                   20


<210> 5750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5750
aaatgatcta tgtagtctcg                                                   20


<210> 5751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5751
tgtaaaatat atcacaattt                                                   20


<210> 5752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5752
gttgttttat atatttgctt                                                   20


<210> 5753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5753
tcccacaaaa atcttctaag                                                   20


<210> 5754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5754
actattaata ggtgttttca                                                   20


<210> 5755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5755
catgtgagtc aagatgaatg                                                   20


<210> 5756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5756
acatggtctt ctgatttatt                                                   20


<210> 5757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5757
ttctgattta ttaaaaacca                                                   20


<210> 5758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5758
tccatctccc cactctcacc                                                   20


<210> 5759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5759
aaaaaatttt catgacattt                                                   20


<210> 5760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5760
ttgcattggc caacaacact                                                   20


<210> 5761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5761
gtgaaaataa caacaacaac                                                   20


<210> 5762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5762
caacaaaaac aagaagatag                                                   20


<210> 5763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5763
aagtattaag ctgtaaaaaa                                                   20


<210> 5764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5764
atgacaagtc tcacatgtgc                                                   20


<210> 5765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5765
tctccagtga aaaggattat                                                   20


<210> 5766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5766
aaaaccacat ttatccaata                                                   20


<210> 5767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5767
aaacaaaaaa taaatgtagt                                                   20


<210> 5768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5768
ctttcttcac aaaattggaa                                                   20


<210> 5769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5769
tactacaagg ctacagtaac                                                   20


<210> 5770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5770
aaacagcatg gtactggtac                                                   20


<210> 5771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5771
tgatccttga caaacctcac                                                   20


<210> 5772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5772
tatttaataa atgatgctgg                                                   20


<210> 5773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5773
aaagacttaa atgtaagacc                                                   20


<210> 5774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5774
aatgtaagac ctaaaaccat                                                   20


<210> 5775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5775
atgggcaaag acttcatgac                                                   20


<210> 5776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5776
aaagcaatgg caacaaaagc                                                   20


<210> 5777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5777
cttaaacaaa tttacaagaa                                                   20


<210> 5778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5778
gtcatcagag aaacacaaat                                                   20


<210> 5779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5779
gtgatgattc ctcaagaatc                                                   20


<210> 5780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5780
agcaaaatat cacaaggacg                                                   20


<210> 5781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5781
cttgacagaa gaagctggag                                                   20


<210> 5782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5782
agctggagaa aaactgagga                                                   20


<210> 5783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5783
caatatgatg aagaatggga                                                   20


<210> 5784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5784
ttgtgcaaaa tgtatccctt                                                   20


<210> 5785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5785
aagtttctta attctttaag                                                   20


<210> 5786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5786
tagtatgttt tatgattatt                                                   20


<210> 5787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5787
tgaggatgat gaatagttgg                                                   20


<210> 5788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5788
acaaaaagtc aaatatcagt                                                   20


<210> 5789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5789
agaatacaat aattgaacta                                                   20


<210> 5790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5790
aagaatcaac aaaccaagaa                                                   20


<210> 5791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5791
aagaaaaaaa caaccccatc                                                   20


<210> 5792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5792
agaagacatt tatgcagcca                                                   20


<210> 5793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5793
gccatcagag aaatgcaaat                                                   20


<210> 5794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5794
cagcaaacta tcgcaaggaa                                                   20


<210> 5795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5795
cacgttgtgc acatgtaccc                                                   20


<210> 5796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5796
aaaaataaaa aataaaatta                                                   20


<210> 5797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5797
gaccagcctg gccaacatgg                                                   20


<210> 5798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5798
aagtttgaaa gcagcaagaa                                                   20


<210> 5799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5799
tattcaaaat acttaaagaa                                                   20


<210> 5800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5800
accaagaata atatacctgg                                                   20


<210> 5801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5801
ctttaaaatt aaggaaggat                                                   20


<210> 5802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5802
aagacagaaa aaaagaatta                                                   20


<210> 5803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5803
caatggctgc atagatttat                                                   20


<210> 5804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5804
gatactcgtt tcagatttaa                                                   20


<210> 5805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5805
attggctgaa tctacagatg                                                   20


<210> 5806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5806
gccaaaatag attttaaata                                                   20


<210> 5807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5807
ctggaagtca gtaatagaag                                                   20


<210> 5808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5808
aaagcaatag aaaaagtcaa                                                   20


<210> 5809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5809
agatagagga ctcaaatatg                                                   20


<210> 5810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5810
taattcttct caaactctct                                                   20


<210> 5811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5811
agaaacccag aatccagtag                                                   20


<210> 5812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5812
cagtgcctta catttgggaa                                                   20


<210> 5813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5813
ggagttttct ctcaagtaca                                                   20


<210> 5814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5814
tcaaagaaga aattatacgg                                                   20


<210> 5815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5815
tttttgaaaa gataaaatcg                                                   20


<210> 5816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5816
ggccagtatt atactgatat                                                   20


<210> 5817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5817
aagagtatgc taccagaaaa                                                   20


<210> 5818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5818
actgaattcc ctagcacatt                                                   20


<210> 5819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5819
gcccacggct aacattatgc                                                   20


<210> 5820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5820
tgacatgatc tttatatgta                                                   20


<210> 5821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5821
aacactctac tgagaactgt                                                   20


<210> 5822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5822
attaagaaat taatcctatt                                                   20


<210> 5823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5823
aagttgaaga tctgtacact                                                   20


<210> 5824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5824
aaaactataa gttgatttaa                                                   20


<210> 5825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5825
tcttcaataa atggtgttgg                                                   20


<210> 5826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5826
tttctcatac catatgttta                                                   20


<210> 5827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5827
aaactataaa gctactagaa                                                   20


<210> 5828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5828
aaaaatagca tggaagttcc                                                   20


<210> 5829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5829
ctgcaattaa aagtaatggc                                                   20


<210> 5830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5830
atgcacagtg cactactata                                                   20


<210> 5831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5831
aaagacttaa atgtaaaatc                                                   20


<210> 5832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5832
aatgtaaaat ctaaaactat                                                   20


<210> 5833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5833
acaccaaaag caactgcaac                                                   20


<210> 5834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5834
accattagag aaatgcaaat                                                   20


<210> 5835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5835
tactatgcag ccattcaaaa                                                   20


<210> 5836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5836
agtaaactaa ggcaggaaca                                                   20


<210> 5837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5837
tctacaatgt ttatgtagat                                                   20


<210> 5838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5838
gaacaaatat ttaaacagaa                                                   20


<210> 5839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5839
tttcaacaac ctttcatggt                                                   20


<210> 5840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5840
catggtaaaa actaaaaaaa                                                   20


<210> 5841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5841
taacatcgta ttcaatggtg                                                   20


<210> 5842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5842
tattcaatgg tgaaaaactg                                                   20


<210> 5843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5843
agccagagaa attaggcaag                                                   20


<210> 5844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5844
gcattgaaaa tgtatgcact                                                   20


<210> 5845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5845
aaaatagtat ggtcctggca                                                   20


<210> 5846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5846
cactcaacaa ataatgttgg                                                   20


<210> 5847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5847
aacatttaaa cctaagacct                                                   20


<210> 5848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5848
aacctaagac ctgaaaactg                                                   20


<210> 5849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5849
aaactgtaaa acttgtagaa                                                   20


<210> 5850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5850
aatcatcaga aaattcaaat                                                   20


<210> 5851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5851
tgacagagtg agactccttc                                                   20


<210> 5852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5852
cgaaactccg tctcaaaaaa                                                   20


<210> 5853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5853
aaaaaaaaaa aaaaaaaaaa                                                   20


<210> 5854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5854
aaaaaaaaaa aacagcaaca                                                   20


<210> 5855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5855
cctgctagga tggctattac                                                   20


<210> 5856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5856
aggatggcta ttaccaaaac                                                   20


<210> 5857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5857
gctattacca aaacaaaaac                                                   20


<210> 5858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5858
aaaatgatgt agctgccata                                                   20


<210> 5859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5859
tatttactgt atccaaatat                                                   20


<210> 5860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5860
atatctactc tcaggcaggt                                                   20


<210> 5861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5861
ctccaaatct taaatttctt                                                   20


<210> 5862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5862
cctctatagg aaacattgga                                                   20


<210> 5863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5863
agaatagttg atatattgct                                                   20


<210> 5864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5864
tccaaggtgt tttaaactgt                                                   20


<210> 5865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5865
tagtgtgaag caggaagttc                                                   20


<210> 5866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5866
gccaagactg gcactgtttt                                                   20


<210> 5867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5867
ttgactaaca ttcataaggg                                                   20


<210> 5868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5868
aataaataaa aataataaac                                                   20


<210> 5869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5869
ttcttattta cttaatcttt                                                   20


<210> 5870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5870
tgttccaaga acatttttac                                                   20


<210> 5871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5871
aatgttcact tgaggctggt                                                   20


<210> 5872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5872
aatggtgaac attttaatta                                                   20


<210> 5873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5873
tcttagtata aatcttatta                                                   20


<210> 5874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5874
tcacaagagt gggtttatta                                                   20


<210> 5875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5875
catcacttta aattttcaaa                                                   20


<210> 5876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5876
tatttggggc agcctttctt                                                   20


<210> 5877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5877
ttaatatgtt gtgtgattaa                                                   20


<210> 5878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5878
attatgtcag gcatcatatg                                                   20


<210> 5879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5879
catatggaaa acaaatctct                                                   20


<210> 5880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5880
aaaatcacat ctcctttgca                                                   20


<210> 5881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5881
tctcctttgc agaaaacata                                                   20


<210> 5882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5882
agcttcatga ttcatttaaa                                                   20


<210> 5883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5883
ggaaggggct tagtcacaag                                                   20


<210> 5884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5884
ttgggacatt aagcaacttt                                                   20


<210> 5885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5885
aacttgtcct acttttatcc                                                   20


<210> 5886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5886
ggggaaaagc tctcagggta                                                   20


<210> 5887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5887
ataacatttt cccattttaa                                                   20


<210> 5888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5888
tcatagggat taattctagg                                                   20


<210> 5889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5889
tacttccact cctctatggt                                                   20


<210> 5890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5890
tgtttcaagt attctaagtt                                                   20


<210> 5891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5891
taggttttgg ttaggtagat                                                   20


<210> 5892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5892
tgaagaaagt ttcataccca                                                   20


<210> 5893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5893
gtggatgtta gcagtgaatt                                                   20


<210> 5894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5894
gggtgggaac ctgaaacggg                                                   20


<210> 5895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5895
ggtgatggag gaaatgccaa                                                   20


<210> 5896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5896
atatcaagca gtcttcatgc                                                   20


<210> 5897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5897
tcactaggac aggtagagga                                                   20


<210> 5898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5898
tcctcataaa attttagatg                                                   20


<210> 5899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5899
aagattgatc tccttttctg                                                   20


<210> 5900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5900
taatcataag ttgtatgttc                                                   20


<210> 5901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5901
agttgtatgt tctaaaacaa                                                   20


<210> 5902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5902
aacattcgat aaaatgatat                                                   20


<210> 5903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5903
ttagaatttg tcttaaactt                                                   20


<210> 5904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5904
attcttatga ttgaggaaat                                                   20


<210> 5905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5905
caaaagacag actattcatt                                                   20


<210> 5906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5906
ttaatttaaa aattgattat                                                   20


<210> 5907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5907
ttcttaacat caaatataac                                                   20


<210> 5908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5908
ttataggaag ggggtgaata                                                   20


<210> 5909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5909
aatctaaaag cagcacaata                                                   20


<210> 5910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5910
ttttaacatt tatcttcagt                                                   20


<210> 5911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5911
catgtcacac cctcactata                                                   20


<210> 5912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5912
attgatgttt ataggattaa                                                   20


<210> 5913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5913
agtagaagga ggtactgtta                                                   20


<210> 5914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5914
atgaacttgt gactagcaag                                                   20


<210> 5915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5915
tttttgcttt tcaaaaaaaa                                                   20


<210> 5916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5916
ctcagatcaa atagttggca                                                   20


<210> 5917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5917
aatacataca gcaactgtag                                                   20


<210> 5918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5918
atcagtacaa aatttcactc                                                   20


<210> 5919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5919
aattataact gaatattcta                                                   20


<210> 5920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5920
tcaaacacag cagcactgta                                                   20


<210> 5921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5921
tacaaaacac agaactcaac                                                   20


<210> 5922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5922
ccagatatta ttgatcagtg                                                   20


<210> 5923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5923
acattctaat tatgggcaac                                                   20


<210> 5924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5924
tttttttaaa aaaagggcaa                                                   20


<210> 5925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5925
accaccagag aaattcagaa                                                   20


<210> 5926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5926
cactttctat ccaataacat                                                   20


<210> 5927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5927
gtaataagaa tttatgaatt                                                   20


<210> 5928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5928
gtcccataac taacagtgca                                                   20


<210> 5929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5929
atgtcattca acagagactt                                                   20


<210> 5930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5930
ttctttggaa acaacctgaa                                                   20


<210> 5931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5931
taataagcag aaggtaaatc                                                   20


<210> 5932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5932
agtcttgata acagtgtaat                                                   20


<210> 5933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5933
atgagtgtaa tttaggagag                                                   20


<210> 5934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5934
ataggcatta atatagaaga                                                   20


<210> 5935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5935
ctgtggatgt tttaaaatat                                                   20


<210> 5936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5936
tcagaaatag ccaaaaataa                                                   20


<210> 5937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5937
accattacag aggtatagca                                                   20


<210> 5938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5938
agatgttacg tttcgttcct                                                   20


<210> 5939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5939
aagaccgaga cacacaggga                                                   20


<210> 5940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5940
ttgaggaaat ctgtcaacct                                                   20


<210> 5941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5941
tctttgtgag gagaccattt                                                   20


<210> 5942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5942
ataggtactt ggaaccttgt                                                   20


<210> 5943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5943
tatctaagat cagatcatat                                                   20


<210> 5944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5944
tattttagtg atctgaatgg                                                   20


<210> 5945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5945
tagtgatctg aatgggaaaa                                                   20


<210> 5946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5946
atctgaatgg gaaaacaaaa                                                   20


<210> 5947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5947
agtacaaata aaaaatatag                                                   20


<210> 5948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5948
actttctaac atgagctaga                                                   20


<210> 5949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5949
gttatatttc acaataaaaa                                                   20


<210> 5950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5950
caattattaa gaactagtaa                                                   20


<210> 5951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5951
tgttgtgtaa agtcacgcac                                                   20


<210> 5952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5952
gtgtttgtcc acgctgcttc                                                   20


<210> 5953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5953
agttctcttt tatgaaccca                                                   20


<210> 5954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5954
cctgtgagaa acaggtagaa                                                   20


<210> 5955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5955
tccctcattt tggtcatacc                                                   20


<210> 5956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5956
tgatatagac ccgagctgac                                                   20


<210> 5957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5957
atctatattg cctttcaaag                                                   20


<210> 5958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5958
attgttcaaa ggcccacttc                                                   20


<210> 5959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5959
tgtgccctaa taagcatctt                                                   20


<210> 5960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5960
accagcctgg ccaacatgac                                                   20


<210> 5961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5961
gctataggag cttataaata                                                   20


<210> 5962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5962
aaggaatttg taaggctata                                                   20


<210> 5963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5963
aaaaaaaaag tacaagccaa                                                   20


<210> 5964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5964
atgctatagg ccagtggctg                                                   20


<210> 5965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5965
aatatgggtt atttggctag                                                   20


<210> 5966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5966
aaaagttttt aaaaataatg                                                   20


<210> 5967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5967
atgtttttct gttaatatta                                                   20


<210> 5968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5968
atattaaaat ttcagaagag                                                   20


<210> 5969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5969
gttctggaag aagataaaaa                                                   20


<210> 5970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5970
aactcagcga gcacatgggg                                                   20


<210> 5971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5971
cctgcctcac atccatagtc                                                   20


<210> 5972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5972
atagccataa ataatgtgtt                                                   20


<210> 5973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5973
atgagactat tctgtccaga                                                   20


<210> 5974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5974
tgctgtaata gttcacaggt                                                   20


<210> 5975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5975
ttatccattt ttaagcacat                                                   20


<210> 5976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5976
tggttatctt taccatcatt                                                   20


<210> 5977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5977
gtcatgtgac agtcctacat                                                   20


<210> 5978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5978
tctagaaatt gttgccatgc                                                   20


<210> 5979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5979
gtgagaaaat gtcttatttt                                                   20


<210> 5980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5980
cttggaaact aattcaaatt                                                   20


<210> 5981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5981
agtcatgcat gtatgtgtat                                                   20


<210> 5982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5982
tcaacttttt gaaaagtctc                                                   20


<210> 5983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5983
tactgatttt tctatggtga                                                   20


<210> 5984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5984
acatattaca cacataattg                                                   20


<210> 5985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5985
atgaaatatt ttttaaaaat                                                   20


<210> 5986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5986
tgcctcaatt ttcccatttg                                                   20


<210> 5987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5987
ccagccatgc ctgagctatg                                                   20


<210> 5988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5988
ttctgctgct tcgccttgca                                                   20


<210> 5989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5989
gtgactgcag aaaaattaaa                                                   20


<210> 5990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5990
gacttaaaag aaacatactt                                                   20


<210> 5991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5991
acgaagcaat tcagtgagaa                                                   20


<210> 5992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5992
gtatggtaag gtctttgcct                                                   20


<210> 5993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5993
atttgtgggg ttgtgtgatg                                                   20


<210> 5994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 5994
gaaaacaggg aagacctaag                                                   20


<210> 5995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 5995
ttttaaccaa tgaagcatta                                                   20


<210> 5996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 5996
tacaaggtaa ttttggaatg                                                   20


<210> 5997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5997
aaacactaaa aaattcttgt                                                   20


<210> 5998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5998
gggaaataaa gatataaatg                                                   20


<210> 5999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 5999
tcatgataaa ataattttaa                                                   20


<210> 6000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6000
aaaaatcctt gtgacattaa                                                   20


<210> 6001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6001
ctcatgatat aataatttaa                                                   20


<210> 6002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6002
agaaaagtta tatcttcatg                                                   20


<210> 6003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6003
acataaacag aaccaatgac                                                   20


<210> 6004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6004
atgcaacatc cattcatgtt                                                   20


<210> 6005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6005
aaataataag agctatttat                                                   20


<210> 6006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6006
aagctggaag cattcccttt                                                   20


<210> 6007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6007
atgacatgat tctatattta                                                   20


<210> 6008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6008
aaacccgatc atctcagccc                                                   20


<210> 6009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6009
gagaggacac aaacaaatgg                                                   20


<210> 6010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6010
ttgacatctt cacagaatta                                                   20


<210> 6011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6011
tactatgagg ttacagtaac                                                   20


<210> 6012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6012
tgatcttcga caaacctgac                                                   20


<210> 6013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6013
aagctggcta gccatatgca                                                   20


<210> 6014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6014
gatggattaa agacttaatg                                                   20


<210> 6015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6015
aatgtaaaac cccaaaccat                                                   20


<210> 6016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6016
aaaccatgaa aaccctagaa                                                   20


<210> 6017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6017
aaataggcca aaaaagaaaa                                                   20


<210> 6018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6018
gagcaattga tttgggagag                                                   20


<210> 6019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6019
tttaaatagg agttcaaaaa                                                   20


<210> 6020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6020
ggccatccca agcacgcatg                                                   20


<210> 6021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6021
catgtgcagg agcagcttga                                                   20


<210> 6022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6022
catattatta gtgatgggag                                                   20


<210> 6023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6023
cctccattct caaataaata                                                   20


<210> 6024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6024
gccattagca tcatcatcat                                                   20


<210> 6025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6025
atccctttgc ttagagtggc                                                   20


<210> 6026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6026
ttcagccttt agactaaaaa                                                   20


<210> 6027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6027
atatatggtc cgctattgac                                                   20


<210> 6028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6028
agtaaatgtt taaatgacta                                                   20


<210> 6029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6029
acattctgta ctagctgctc                                                   20


<210> 6030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6030
aactattata caatttgaga                                                   20


<210> 6031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6031
tcttacttag aagacacaga                                                   20


<210> 6032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6032
tgtgcatgaa aagctttcct                                                   20


<210> 6033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6033
tagctcactc taggtttgta                                                   20


<210> 6034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6034
aattgaaaat gtatttccac                                                   20


<210> 6035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6035
ctataccatg gataaatttt                                                   20


<210> 6036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6036
ggcaaataat gcaactctga                                                   20


<210> 6037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6037
ggcaaatgta gttctcacaa                                                   20


<210> 6038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6038
ggccaatatt gcggtttttt                                                   20


<210> 6039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6039
tattaaatgt caaatattag                                                   20


<210> 6040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6040
atcttatact ttgaggaaat                                                   20


<210> 6041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6041
tactcattca ttatcactag                                                   20


<210> 6042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6042
cactagcaaa acatccatac                                                   20


<210> 6043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6043
tgatttaaac acctcttcac                                                   20


<210> 6044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6044
tttcttttaa caaaggttaa                                                   20


<210> 6045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6045
aaaaggacag atcccagtga                                                   20


<210> 6046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6046
atatgctaaa cattttactt                                                   20


<210> 6047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6047
ctatattgaa ggaagccatt                                                   20


<210> 6048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6048
attattttca agtgaatttc                                                   20


<210> 6049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6049
aaagcctctg aatcgaaaca                                                   20


<210> 6050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6050
cacttctcta taaatggcac                                                   20


<210> 6051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6051
tggtttgctg agaaaaaata                                                   20


<210> 6052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6052
cttcctgtat aagcaaatgg                                                   20


<210> 6053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6053
gacttttgat aatgattgtg                                                   20


<210> 6054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6054
tttagacttt taatttttta                                                   20


<210> 6055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6055
aatagacaaa tccatagaga                                                   20


<210> 6056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6056
gcaagtttgt caatatactg                                                   20


<210> 6057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6057
aaagctgaaa gtacttacgc                                                   20


<210> 6058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6058
aaaatacacc catataatta                                                   20


<210> 6059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6059
ctgacaagtt cattctttga                                                   20


<210> 6060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6060
aaaggatgaa atgataatac                                                   20


<210> 6061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6061
taatactgaa attaataaac                                                   20


<210> 6062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6062
tatctctaat atttttatca                                                   20


<210> 6063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6063
ttactaacca cggtaattta                                                   20


<210> 6064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6064
ttagtattca gttaagaaat                                                   20


<210> 6065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6065
atgcggcagc gttccctcaa                                                   20


<210> 6066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6066
cccgtctcta ctaaaaatac                                                   20


<210> 6067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6067
tagcaatttt cattctcatt                                                   20


<210> 6068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6068
actttcttca cagaactgga                                                   20


<210> 6069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6069
aaacagcatg gtactggtac                                                   20


<210> 6070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6070
tgatctttga caaacctgag                                                   20


<210> 6071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6071
tatttaacaa atggtgctgg                                                   20


<210> 6072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6072
aaagacttaa acattagacc                                                   20


<210> 6073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6073
aacattagac ctaaaaccat                                                   20


<210> 6074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6074
aaaccataaa aaccctagaa                                                   20


<210> 6075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6075
atgggcaagg acttcatgtc                                                   20


<210> 6076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6076
ctcaaacaaa tttacaagaa                                                   20


<210> 6077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6077
agaagacatt tatgcagcca                                                   20


<210> 6078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6078
gccatcagag aaatgcaaat                                                   20


<210> 6079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6079
agtaaactat cacaagaata                                                   20


<210> 6080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6080
cacaatgtgc acatgtaccc                                                   20


<210> 6081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6081
cctgccaaga aaggcccatt                                                   20


<210> 6082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6082
tgatcttcta tctagatcac                                                   20


<210> 6083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6083
ggatgtggtt catagcaccc                                                   20


<210> 6084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6084
ggtacagact caagggaatt                                                   20


<210> 6085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6085
ctgaattagt atttagcaat                                                   20


<210> 6086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6086
tgttacaaca tggatgtgat                                                   20


<210> 6087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6087
ttggggtgat aaaaatattc                                                   20


<210> 6088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6088
catacctttg tgaacatact                                                   20


<210> 6089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6089
gtgtgtaaat tatatcttaa                                                   20


<210> 6090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6090
atatctcata aaatttagta                                                   20


<210> 6091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6091
cttcaaattt ccattgcagt                                                   20


<210> 6092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6092
aaatgttaga taatatcact                                                   20


<210> 6093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6093
caaatatgtg atgtagatca                                                   20


<210> 6094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6094
atttattcaa taatgttgca                                                   20


<210> 6095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6095
aaaaaaaaaa ataggctacc                                                   20


<210> 6096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6096
aaaattaaaa aagtacaaaa                                                   20


<210> 6097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6097
caaaaaaaaa aaagtacttc                                                   20


<210> 6098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6098
ccatagaatt acttagaaat                                                   20


<210> 6099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6099
attttcaaat tagaaagtta                                                   20


<210> 6100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6100
gataaaaagg aaaatatcag                                                   20


<210> 6101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6101
agaagagttg gaatgagggg                                                   20


<210> 6102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6102
gtctttccta gcatttattt                                                   20


<210> 6103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6103
actttatgaa acactactta                                                   20


<210> 6104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6104
ggctctgaac atactatttg                                                   20


<210> 6105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6105
tttcatcccc aaggtactat                                                   20


<210> 6106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6106
acatatgtga tcttccttcc                                                   20


<210> 6107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6107
ctcaaagtat caacatcatc                                                   20


<210> 6108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6108
agagaaaaag gaaattagtg                                                   20


<210> 6109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6109
tcttataggc cttctcccat                                                   20


<210> 6110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6110
aaaaatttcc agatggatct                                                   20


<210> 6111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6111
aggtctgtga aaccccttga                                                   20


<210> 6112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6112
tcccctagtc tagattcagt                                                   20


<210> 6113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6113
tctatacact taagtagagt                                                   20


<210> 6114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6114
gatgaacgta aaatgttttt                                                   20


<210> 6115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6115
ttttaaaaac ttctttttct                                                   20


<210> 6116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6116
ggtttatgtt ttatggtttt                                                   20


<210> 6117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6117
ccttaccatt atttgtatat                                                   20


<210> 6118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6118
aattttttct ctgttgtgta                                                   20


<210> 6119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6119
ttccttactt ttcaaattac                                                   20


<210> 6120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6120
agggcttaca gtctgttggg                                                   20


<210> 6121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6121
tacttttgct tctggtatga                                                   20


<210> 6122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6122
tgtgggaact aggttatgac                                                   20


<210> 6123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6123
tttctgcaat atccacagtc                                                   20


<210> 6124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6124
aatcacagat gtaaatataa                                                   20


<210> 6125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6125
atgatgctaa cttactacaa                                                   20


<210> 6126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6126
ttaaaaatat tttccactga                                                   20


<210> 6127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6127
ctaagttgtg ttgttcctct                                                   20


<210> 6128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6128
atggctatgc cataaaaaag                                                   20


<210> 6129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6129
caaattaagt catgtgagct                                                   20


<210> 6130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6130
attgttcata aaatttatca                                                   20


<210> 6131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6131
atgatcaagt ccatattttg                                                   20


<210> 6132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6132
aagatcggtt accaagtgaa                                                   20


<210> 6133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6133
gtacataaat gatcatagta                                                   20


<210> 6134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6134
gatcatagta caaaacatgg                                                   20


<210> 6135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6135
tgtctaacgc ccatgtgtac                                                   20


<210> 6136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6136
acattagagg aaggatgttt                                                   20


<210> 6137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6137
aaactgtcct tgtaattaaa                                                   20


<210> 6138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6138
gcatctatat ttaaattaac                                                   20


<210> 6139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6139
actctacagt attacagctt                                                   20


<210> 6140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6140
gcttgaaaac aaagaaaaga                                                   20


<210> 6141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6141
atttgacatg ggttttcttt                                                   20


<210> 6142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6142
tagtgtttcc acattgattg                                                   20


<210> 6143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6143
acctttttag aagaaaagtt                                                   20


<210> 6144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6144
ggctatttaa agtttgtaca                                                   20


<210> 6145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6145
aacaatctac acatgcagtg                                                   20


<210> 6146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6146
catccctacc ttcatgctgc                                                   20


<210> 6147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6147
acatagagtg cattgagttt                                                   20


<210> 6148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6148
tcaatgtttt atttcaaaaa                                                   20


<210> 6149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6149
gaagtaaagg cttcacatat                                                   20


<210> 6150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6150
tttgtgcaaa cagggaaaga                                                   20


<210> 6151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6151
atagctgtat gattagatga                                                   20


<210> 6152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6152
agcttatatc cgcctctttt                                                   20


<210> 6153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6153
aaggggttta ttgattgata                                                   20


<210> 6154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6154
gatataaaac taagttccag                                                   20


<210> 6155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6155
catttcaaat taatagagga                                                   20


<210> 6156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6156
aaacaaacaa acatacaaac                                                   20


<210> 6157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6157
tacactttcc aatattactg                                                   20


<210> 6158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6158
tgaaaagagt aaacaagcaa                                                   20


<210> 6159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6159
aaagtaagat tttaatattt                                                   20


<210> 6160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6160
ttcagctgct accctgacaa                                                   20


<210> 6161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6161
agaaagacac aaaaatacag                                                   20


<210> 6162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6162
aatcaataaa tgatgacacg                                                   20


<210> 6163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6163
aggaggataa atatttaaaa                                                   20


<210> 6164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6164
ttcaggatgg gcaacaagag                                                   20


<210> 6165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6165
caacaagagc aaaactccgt                                                   20


<210> 6166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6166
aacaaacaaa caaacaaaca                                                   20


<210> 6167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6167
aattaggtca caatattcct                                                   20


<210> 6168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6168
gtctgcaata tttctcattt                                                   20


<210> 6169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6169
ttaaagtatc tctgggcacc                                                   20


<210> 6170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6170
gtaaggagag agattatcag                                                   20


<210> 6171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6171
ctatatgtgc ctcagaaaca                                                   20


<210> 6172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6172
gacttttttt ataatatttt                                                   20


<210> 6173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6173
gcctaaaaag aagaataata                                                   20


<210> 6174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6174
aaagaagaat aatacaaaac                                                   20


<210> 6175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6175
ggatgatatg tgtcaaaggt                                                   20


<210> 6176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6176
aaacccgtaa aatggggaga                                                   20


<210> 6177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6177
taaataacaa gttaaaaaga                                                   20


<210> 6178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6178
aggaaagcaa gcttcaatca                                                   20


<210> 6179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6179
agaactatga gcattcaact                                                   20


<210> 6180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6180
ttttttaatt tctttcttat                                                   20


<210> 6181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6181
tgtgctacaa aaaaatgcct                                                   20


<210> 6182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6182
tttctcctca ttaaaaaaat                                                   20


<210> 6183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6183
ttaaaaaaat taaaacattg                                                   20


<210> 6184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6184
gtgacatcga aatacaattt                                                   20


<210> 6185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6185
tttcattggg agaaaattta                                                   20


<210> 6186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6186
ttaagtatag tcatttaaaa                                                   20


<210> 6187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6187
aaacttcata atttgatatt                                                   20


<210> 6188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6188
tcttttaact ttgtctttac                                                   20


<210> 6189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6189
tacacacata atggtttgca                                                   20


<210> 6190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6190
ttgaagaata aatttagcca                                                   20


<210> 6191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6191
tgagcctaat aagtggggaa                                                   20


<210> 6192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6192
atgagccacc acacccggcc                                                   20


<210> 6193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6193
tctcaggtga aaagaaaaaa                                                   20


<210> 6194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6194
ggtgaaaaga aaaaagaaaa                                                   20


<210> 6195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6195
atacctcttc tttagattat                                                   20


<210> 6196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6196
gccaagtata atatcacaag                                                   20


<210> 6197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6197
gtagttgaac aactggtatg                                                   20


<210> 6198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6198
taagaagtgt attaccctgg                                                   20


<210> 6199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6199
atacatgtat ccacttccct                                                   20


<210> 6200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6200
catgagttgg ccaataaaca                                                   20


<210> 6201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6201
aagcttttgt attgcatata                                                   20


<210> 6202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6202
actaaaatgt atgcttatag                                                   20


<210> 6203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6203
atgttgaaag atttaataac                                                   20


<210> 6204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6204
ggaacatttg tggacattgt                                                   20


<210> 6205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6205
gataaagcaa gtgcataggc                                                   20


<210> 6206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6206
aacctccaca aggattgtct                                                   20


<210> 6207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6207
tgtggtataa acactaacct                                                   20


<210> 6208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6208
tttcggtaac aaactcttct                                                   20


<210> 6209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6209
ctcttctgaa aacactttaa                                                   20


<210> 6210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6210
ttgatctact tgaccgttga                                                   20


<210> 6211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6211
tttaatactg gtataaaaga                                                   20


<210> 6212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6212
gtataaaaga aaaaacagaa                                                   20


<210> 6213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6213
gagtaaggca cattcagact                                                   20


<210> 6214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6214
atcatttggg aaatgcaaat                                                   20


<210> 6215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6215
aaaatagtgc agctgctgtg                                                   20


<210> 6216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6216
aatcacagta gccaaaaagt                                                   20


<210> 6217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6217
acgacccgga tgaacacctt                                                   20


<210> 6218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6218
tctaaatcac aaaaaaagac                                                   20


<210> 6219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6219
gtaatcccta caaaatcaag                                                   20


<210> 6220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6220
gctatatctg atgtctacaa                                                   20


<210> 6221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6221
ttatctcatt gcagtgctga                                                   20


<210> 6222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6222
tgtaaaataa attagttttc                                                   20


<210> 6223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6223
ttagttttcc aaaactgttt                                                   20


<210> 6224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6224
ccatttcagt tttttaatgt                                                   20


<210> 6225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6225
aagtgaagtc attcaaccta                                                   20


<210> 6226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6226
tcaacctata aaacaacttc                                                   20


<210> 6227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6227
tggtgaaacc ccatctctac                                                   20


<210> 6228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6228
ggcacacctt tacctatgta                                                   20


<210> 6229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6229
actaaagtgg ctgttttgga                                                   20


<210> 6230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6230
aaaataatta cattggattt                                                   20


<210> 6231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6231
tccgtctcta ctaaaaatac                                                   20


<210> 6232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6232
tttcaaccaa atgttaatag                                                   20


<210> 6233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6233
atgatcaaaa atgatctttc                                                   20


<210> 6234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6234
aaatgatctt tccaaaacaa                                                   20


<210> 6235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6235
tcagcacagc aacaggtagt                                                   20


<210> 6236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6236
atcatatatc cagtcactgt                                                   20


<210> 6237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6237
taaacctcta caaaatttta                                                   20


<210> 6238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6238
cttactgaca ctagcttctt                                                   20


<210> 6239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6239
aacgctccaa cttaaaaaaa                                                   20


<210> 6240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6240
gaaatgttta ctataatcac                                                   20


<210> 6241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6241
tggcagcaaa cccacagagt                                                   20


<210> 6242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6242
ggcttggtgg ggagctggag                                                   20


<210> 6243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6243
gagcaatttt aggttcacag                                                   20


<210> 6244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: TAAAAC

<400> 6244
cataaaatcc tggaaaatga                                                   20


<210> 6245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6245
acaattgcca ctgcaatttt                                                   20


<210> 6246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: AAAAAC

<400> 6246
ggcaatatta caaagtaaga                                                   20


<210> 6247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6247
ggtctggatt tttttggcca                                                   20


<210> 6248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6248
tctgtggagt tatttttgat                                                   20


<210> 6249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: GAAAAC

<400> 6249
acagcattct gcaattgtgt                                                   20


<210> 6250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NAAAAC; 
      PAM sequence: CAAAAC

<400> 6250
cagtcaaagt gaaaagacct                                                   20


<210> 6251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 6251
tcctctatag ctttaacaaa                                                   20


<210> 6252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 6252
gctcacaaaa taaaattagt                                                   20


<210> 6253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 6253
tggattcaac caattctgga                                                   20


<210> 6254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 6254
tagactgggt ggctagaaca                                                   20


<210> 6255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 6255
ttatcatttt tgtgttggtc                                                   20


<210> 6256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 6256
tgcctttaaa atgtaggcca                                                   20


<210> 6257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 6257
agtaattttc tcaaagtcaa                                                   20


<210> 6258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6258
caaattttta cccagaagcc                                                   20


<210> 6259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 6259
ctcgcccgca aaagactgat                                                   20


<210> 6260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 6260
aatacagatg agcaacgcta                                                   20


<210> 6261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 6261
ttccaatgta ccatgttaag                                                   20


<210> 6262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 6262
cactaattcc ttctaacaga                                                   20


<210> 6263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 6263
agaatgatat cttgctcata                                                   20


<210> 6264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 6264
actgctcatt tttatatgag                                                   20


<210> 6265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 6265
gagaactgct catttttata                                                   20


<210> 6266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 6266
aaattatatc cagtgaatat                                                   20


<210> 6267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 6267
tttttagtga tgtgtaaaat                                                   20


<210> 6268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 6268
aagcaatgca caataagtat                                                   20


<210> 6269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 6269
gaatcttttt aaatatatct                                                   20


<210> 6270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 6270
ggtaatctct ctcaagggag                                                   20


<210> 6271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 6271
tgcaatagcc actctgcaaa                                                   20


<210> 6272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 6272
tagaatgaga caagcttcat                                                   20


<210> 6273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 6273
ttcattatgt ggttgtaatg                                                   20


<210> 6274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 6274
acatcaaggt ttgtgcaaag                                                   20


<210> 6275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 6275
cgggaaacaa agacaaggac                                                   20


<210> 6276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 6276
acacgtattt tctgtttcag                                                   20


<210> 6277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 6277
tgacacattg taatataatc                                                   20


<210> 6278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 6278
atcttcttga ggaaaacaat                                                   20


<210> 6279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 6279
cagttctaaa tagctatttc                                                   20


<210> 6280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 6280
gttacactga agaacttaac                                                   20


<210> 6281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 6281
aacttattac acccaacaat                                                   20


<210> 6282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 6282
tcaattaaaa ataatatttg                                                   20


<210> 6283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 6283
gatttttaaa tacattcaat                                                   20


<210> 6284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAT

<400> 6284
taaagaatga gatcagaagt                                                   20


<210> 6285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 6285
agaaacaaag atttatggtt                                                   20


<210> 6286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 6286
aagaggattt aaacgtacct                                                   20


<210> 6287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6287
ttgttgttct ggcaatttaa                                                   20


<210> 6288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 6288
gcaaaaattg agctacacag                                                   20


<210> 6289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6289
acctattaat agtaatttga                                                   20


<210> 6290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 6290
tcaaaaaaaa caaagataac                                                   20


<210> 6291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 6291
tttcatatcc ctttttgttc                                                   20


<210> 6292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 6292
taaataaaca acacacgcat                                                   20


<210> 6293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 6293
ttaataaatc agaagaccat                                                   20


<210> 6294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 6294
tttttgcact gatgattctt                                                   20


<210> 6295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 6295
agtcactaac tctgatttcc                                                   20


<210> 6296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 6296
agaaatatga acaagacaga                                                   20


<210> 6297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 6297
agtgtaacaa agccagacaa                                                   20


<210> 6298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 6298
atgttaatga gaactcaagt                                                   20


<210> 6299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 6299
attctcttcg ttcacagatg                                                   20


<210> 6300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 6300
agaattttag tgttgccact                                                   20


<210> 6301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 6301
atgtacattg cagtcatact                                                   20


<210> 6302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 6302
aaaaaactgt cttgaattca                                                   20


<210> 6303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 6303
ctactcggga ggctgaggca                                                   20


<210> 6304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 6304
gcccatgaac ttagtaaaaa                                                   20


<210> 6305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 6305
gtgtgtgtac atgtgcttgc                                                   20


<210> 6306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 6306
ctactctgga ggctgaggct                                                   20


<210> 6307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 6307
agcactatca tatactgcca                                                   20


<210> 6308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 6308
ttttggtaaa aaactataaa                                                   20


<210> 6309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 6309
aaattgttct tataaattaa                                                   20


<210> 6310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 6310
agaaaggatc aatactttaa                                                   20


<210> 6311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CGAGAAA

<400> 6311
gtttacataa cagttaaggc                                                   20


<210> 6312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 6312
aagccaaaaa aaaaaatgaa                                                   20


<210> 6313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 6313
aatgattcta aattcatctg                                                   20


<210> 6314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6314
gaagaaaact ttaggatata                                                   20


<210> 6315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 6315
ctttatcata tgagacttct                                                   20


<210> 6316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 6316
tatcttatac atgaaaaaaa                                                   20


<210> 6317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 6317
gaacttgttc atatattgaa                                                   20


<210> 6318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 6318
tgttggccaa tgcaattaga                                                   20


<210> 6319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 6319
aaaatgtatt aaaatttagg                                                   20


<210> 6320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 6320
aagtcatacc aaaattgata                                                   20


<210> 6321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 6321
aaggttcaag gttgcatgac                                                   20


<210> 6322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 6322
ttttaggatt gtatttcttt                                                   20


<210> 6323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 6323
ttaaagtgaa gttaagatct                                                   20


<210> 6324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAT

<400> 6324
gtgaatttgt gaaaattctt                                                   20


<210> 6325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAT

<400> 6325
attaatgata atattaatag                                                   20


<210> 6326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 6326
ttgagtaagt cagtacaatg                                                   20


<210> 6327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 6327
gtgattatct ccattgtagg                                                   20


<210> 6328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 6328
tttttataat ccttttcact                                                   20


<210> 6329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 6329
tcaacatggt aaccatgatg                                                   20


<210> 6330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 6330
atctttatga cagaagaaca                                                   20


<210> 6331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 6331
ttaacctatt ttagtaatct                                                   20


<210> 6332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 6332
caacactgat tagcacacca                                                   20


<210> 6333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 6333
tagttttttt ccaattttgt                                                   20


<210> 6334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 6334
ccgtccttgt gatattttgc                                                   20


<210> 6335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 6335
gagtttcttg aaatagagat                                                   20


<210> 6336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 6336
tttatgttga aatcctttat                                                   20


<210> 6337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 6337
attgataact tcctcagtac                                                   20


<210> 6338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 6338
tgtaaaactt acagctaact                                                   20


<210> 6339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 6339
aggtgaaatt atagactaat                                                   20


<210> 6340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 6340
gctgaatatt accaaatcca                                                   20


<210> 6341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 6341
accattaggt gtttgatgaa                                                   20


<210> 6342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAA

<400> 6342
aacaacaaaa acactctaag                                                   20


<210> 6343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 6343
ctacttggga ggctgagaca                                                   20


<210> 6344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 6344
gaaaaaaact agcctgactt                                                   20


<210> 6345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 6345
gcctcaatgt agattgtaac                                                   20


<210> 6346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6346
aagaaactta cccaaggaca                                                   20


<210> 6347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 6347
ggtggtttta cttaaagaat                                                   20


<210> 6348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 6348
atgatgaggt ggttttactt                                                   20


<210> 6349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 6349
gaaaatgaat aaattagccc                                                   20


<210> 6350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 6350
gcattggtgt ctgtgcattg                                                   20


<210> 6351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 6351
ttttccttgc gatagtttgc                                                   20


<210> 6352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 6352
gttcaattcc cacctatgag                                                   20


<210> 6353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 6353
tgctctttta aagtttccac                                                   20


<210> 6354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 6354
tccctcagca tttgcttgta                                                   20


<210> 6355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 6355
tttgacattt aacttttata                                                   20


<210> 6356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 6356
acctgatatg tgatctatcc                                                   20


<210> 6357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 6357
aaagttttaa gagagtttga                                                   20


<210> 6358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 6358
gtctttgtct ggctttgata                                                   20


<210> 6359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 6359
gtttacttgg tacgtccatg                                                   20


<210> 6360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 6360
cactctagaa aaagcatttt                                                   20


<210> 6361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 6361
atctcttctc tctttacact                                                   20


<210> 6362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 6362
cccatcgttt tttgtacttg                                                   20


<210> 6363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6363
tcaaaaaaaa aaaaaaaaaa                                                   20


<210> 6364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 6364
ctactcggga ggctgaggca                                                   20


<210> 6365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6365
gagaccttcc acatctttta                                                   20


<210> 6366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 6366
tagttcaagc cttcctctaa                                                   20


<210> 6367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 6367
gagtgtttca tgtgatttga                                                   20


<210> 6368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 6368
ctagtttcat gtcatcatga                                                   20


<210> 6369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 6369
aattcatatt acttctttaa                                                   20


<210> 6370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 6370
aattttttgg aagaatttga                                                   20


<210> 6371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 6371
acctcctttt caattttttg                                                   20


<210> 6372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 6372
atttttggat ctatgttcat                                                   20


<210> 6373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 6373
ttgtcttgtt cctgatctta                                                   20


<210> 6374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 6374
ggatacctca ttgttaatgt                                                   20


<210> 6375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 6375
tatttctgtg aaaactgaca                                                   20


<210> 6376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 6376
ggttttataa acatatggta                                                   20


<210> 6377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 6377
tgtgctttta gagtcctagc                                                   20


<210> 6378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 6378
gccattcata tctcttcttt                                                   20


<210> 6379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 6379
tgtgtgcatg tgtctttata                                                   20


<210> 6380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 6380
cacttatcat ttttttgtgg                                                   20


<210> 6381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 6381
ttttgatcta cataaacatt                                                   20


<210> 6382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 6382
tggcacaaag agagaataag                                                   20


<210> 6383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 6383
atgatacaca tggcacaaag                                                   20


<210> 6384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 6384
catccatttg tgctactata                                                   20


<210> 6385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 6385
agattgttta ttgttagtgt                                                   20


<210> 6386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 6386
ataaataaat aaataagaaa                                                   20


<210> 6387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 6387
tctctcaata aataaataaa                                                   20


<210> 6388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 6388
tttttgtgta tggtataata                                                   20


<210> 6389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 6389
ttgaattttg gagtcattgc                                                   20


<210> 6390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6390
gtgatgaact catttattcc                                                   20


<210> 6391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 6391
tctgaccttt tctgaatgat                                                   20


<210> 6392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 6392
ataggataaa ttaagcgtgt                                                   20


<210> 6393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 6393
ctaaatggta gaattacaaa                                                   20


<210> 6394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 6394
agatctttgg agactaaatg                                                   20


<210> 6395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 6395
ccattaaaac attttagagg                                                   20


<210> 6396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 6396
aattagtcct gtgtgtcaat                                                   20


<210> 6397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAT

<400> 6397
gtttcattat ggatctagct                                                   20


<210> 6398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 6398
tagtatcctc atttaacctc                                                   20


<210> 6399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 6399
attcatatat gttgagtagg                                                   20


<210> 6400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 6400
tttgaagaaa tttaagattt                                                   20


<210> 6401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 6401
atagcaatgc tttcggtttt                                                   20


<210> 6402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 6402
gctaacccac atggagtgaa                                                   20


<210> 6403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 6403
catgtagcaa cggagaggca                                                   20


<210> 6404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 6404
gagtaaaaat agatgctgct                                                   20


<210> 6405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 6405
tataatcatg ataaatacaa                                                   20


<210> 6406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 6406
catgttctct ttaaagcctc                                                   20


<210> 6407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 6407
aaacctgagg gcttaaaaca                                                   20


<210> 6408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAT

<400> 6408
ctcaaggagt ttatgtcata                                                   20


<210> 6409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 6409
cctatagagg attgaataat                                                   20


<210> 6410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 6410
ttaatcttat tcatttttgc                                                   20


<210> 6411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 6411
atcatagata atttcaacca                                                   20


<210> 6412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6412
acctggtcaa accatgtgaa                                                   20


<210> 6413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6413
taaagatgta ttcggaatca                                                   20


<210> 6414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 6414
atgtgaaata agttccatgc                                                   20


<210> 6415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 6415
atagtgttgt gaggacccaa                                                   20


<210> 6416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 6416
aaactctgtt tatggctatt                                                   20


<210> 6417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 6417
taattaactg ggactaagat                                                   20


<210> 6418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 6418
tcacaggcaa ctgtaacaat                                                   20


<210> 6419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 6419
tggagaaccc tttaaaaaat                                                   20


<210> 6420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 6420
ctgcttggga ggctgaggca                                                   20


<210> 6421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6421
ctcaaaaaaa gagaataaga                                                   20


<210> 6422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 6422
aatgtctcaa aaaaagagaa                                                   20


<210> 6423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 6423
gtggagaatg tctcaaaaaa                                                   20


<210> 6424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 6424
aagattctca atccttttgt                                                   20


<210> 6425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6425
gcagaaataa agaaaggatt                                                   20


<210> 6426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6426
aaatgctgaa aagcagaaat                                                   20


<210> 6427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAA

<400> 6427
agcagtacaa atgctgaaaa                                                   20


<210> 6428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 6428
gttttgaaag attaagtaaa                                                   20


<210> 6429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAA

<400> 6429
gagaacctgc ttaatacatt                                                   20


<210> 6430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 6430
ctgtaagaat ctgatgaaag                                                   20


<210> 6431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 6431
ttttgaggtc acatagactg                                                   20


<210> 6432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 6432
ataccacatg gtagggaggc                                                   20


<210> 6433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 6433
tccatcatta ctcacatttt                                                   20


<210> 6434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 6434
ttacaggtga attggatgca                                                   20


<210> 6435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 6435
acttaatttt ttgagcatta                                                   20


<210> 6436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 6436
ttttgtgcag aaaggtggta                                                   20


<210> 6437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAA

<400> 6437
aattacaagt ttcattttgt                                                   20


<210> 6438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6438
tataacggtt tccaagtata                                                   20


<210> 6439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 6439
cagaaactcc aggatgggga                                                   20


<210> 6440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 6440
ctcaccccag acctactgag                                                   20


<210> 6441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 6441
ctactaggga ggctgaggca                                                   20


<210> 6442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 6442
aattataact aaattatatt                                                   20


<210> 6443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 6443
aactacctgg gtaaggagca                                                   20


<210> 6444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 6444
gtgttcaaat aatatttgtt                                                   20


<210> 6445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 6445
ttatctaata ttgtcaaaca                                                   20


<210> 6446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 6446
actattatat attaatatat                                                   20


<210> 6447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 6447
aatataaaaa caatgggtat                                                   20


<210> 6448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 6448
tagatttgaa ggaatgaggg                                                   20


<210> 6449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 6449
tgagttgctt ttagtgagtt                                                   20


<210> 6450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 6450
tcttttaaat ctatttcctt                                                   20


<210> 6451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 6451
tatgcatgat ttctattcaa                                                   20


<210> 6452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 6452
cacactttta gggcttagct                                                   20


<210> 6453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 6453
tagggcagaa gcaatcttgt                                                   20


<210> 6454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 6454
tagatctttg gtgctaatct                                                   20


<210> 6455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6455
gactggttaa agtattcaat                                                   20


<210> 6456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 6456
gtatatatac gtgtgtgttt                                                   20


<210> 6457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 6457
acttatatta tttgctactc                                                   20


<210> 6458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 6458
caaccccaag acatactgaa                                                   20


<210> 6459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 6459
tttttttttt tctgaaaagt                                                   20


<210> 6460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAA

<400> 6460
tgttcagggg tatgtaatgt                                                   20


<210> 6461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 6461
ctcattttca tcattcagtg                                                   20


<210> 6462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 6462
agaaaggctg ccccaaataa                                                   20


<210> 6463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 6463
ttttgtaata tagtagtttt                                                   20


<210> 6464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 6464
gttatcttag gtttcctcta                                                   20


<210> 6465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 6465
ctactcagga ggctgaggca                                                   20


<210> 6466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 6466
catacagcat catatgtgga                                                   20


<210> 6467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 6467
ggtttgcatt atcgagcttt                                                   20


<210> 6468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 6468
acctaacctt tgtgtttagg                                                   20


<210> 6469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 6469
ttactaattc ttctagattt                                                   20


<210> 6470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 6470
atctcccagt cttatttttc                                                   20


<210> 6471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 6471
gtgagatcaa ggactctcaa                                                   20


<210> 6472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 6472
aggcttctga ttgagataga                                                   20


<210> 6473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 6473
ttacatatta ttttaacgaa                                                   20


<210> 6474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAT

<400> 6474
atgcgacttg cccttcatct                                                   20


<210> 6475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 6475
gatttgaatg tcattcttgt                                                   20


<210> 6476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 6476
tatctgtgag gaatattaga                                                   20


<210> 6477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 6477
caggctatag gtttattctt                                                   20


<210> 6478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 6478
atgtttcagc agtcttagca                                                   20


<210> 6479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 6479
tgttatatga taactgtaaa                                                   20


<210> 6480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 6480
aggacttatc caattttaat                                                   20


<210> 6481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 6481
aggaagcacc gcattaatgg                                                   20


<210> 6482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 6482
taatagtgtt tcgatctgaa                                                   20


<210> 6483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 6483
gaaagcagaa cgtagaataa                                                   20


<210> 6484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 6484
tagagtattg aaagcagaac                                                   20


<210> 6485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAT

<400> 6485
agatggcttg cctgattcct                                                   20


<210> 6486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 6486
tctgaccctg tacaccagtt                                                   20


<210> 6487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 6487
gaaagaagag tatacacaaa                                                   20


<210> 6488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 6488
tttcactgtg ttgtggctcc                                                   20


<210> 6489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 6489
tagcttatac ttattgtgtt                                                   20


<210> 6490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 6490
ttttaaataa atcatatgag                                                   20


<210> 6491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 6491
tgctgactca catatgtgac                                                   20


<210> 6492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 6492
ccttacctgg agtcatccaa                                                   20


<210> 6493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 6493
ctcagaaaca gaaaatgtga                                                   20


<210> 6494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 6494
tcaagtctca actctcagaa                                                   20


<210> 6495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 6495
ttcctatcaa gtctcaactc                                                   20


<210> 6496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 6496
gaagtttcat tatactaaaa                                                   20


<210> 6497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 6497
tgagagttga aagagatcta                                                   20


<210> 6498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 6498
acaggtggcc agagatacta                                                   20


<210> 6499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 6499
taaatggtgc ttttcagggt                                                   20


<210> 6500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 6500
gagaacaact gcttgcaatt                                                   20


<210> 6501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 6501
gctcagagca atggagaaga                                                   20


<210> 6502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 6502
gcttcaacag tcagtcttgc                                                   20


<210> 6503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 6503
aaatgttata tattgctctt                                                   20


<210> 6504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 6504
ccagatggct ataatagaaa                                                   20


<210> 6505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 6505
ggaccaccca gatggctata                                                   20


<210> 6506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAT

<400> 6506
atcatggcaa gttgttttac                                                   20


<210> 6507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 6507
tatttggttg agggagtatc                                                   20


<210> 6508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 6508
taaaactaac taacaactat                                                   20


<210> 6509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 6509
aaattgggga ttacagaaga                                                   20


<210> 6510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 6510
aagactgtgg aggagactga                                                   20


<210> 6511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 6511
agactagaaa aatttatctg                                                   20


<210> 6512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 6512
gaagtatcta aaattataga                                                   20


<210> 6513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 6513
actaattttc tcaatattgt                                                   20


<210> 6514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 6514
aagtcacatt tgtttttaac                                                   20


<210> 6515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 6515
taacaagggt ttgatggaca                                                   20


<210> 6516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 6516
ctctactgat ctctctttct                                                   20


<210> 6517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAT

<400> 6517
cctccagaca ggatactgga                                                   20


<210> 6518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 6518
acatgtatgc taattattac                                                   20


<210> 6519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 6519
tctcccttaa tattgttgtt                                                   20


<210> 6520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 6520
aatttctgac agtttaacaa                                                   20


<210> 6521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 6521
acctttcctt aaggtaagtt                                                   20


<210> 6522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 6522
cagagagaat agaccaccgt                                                   20


<210> 6523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 6523
gtccagagag aataatccag                                                   20


<210> 6524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 6524
agcatattac tactgtccag                                                   20


<210> 6525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 6525
cagatagaat agaccagcat                                                   20


<210> 6526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 6526
atccagatag aataggccag                                                   20


<210> 6527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 6527
gacatacttc caccatccag                                                   20


<210> 6528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 6528
atcaccttct taattctact                                                   20


<210> 6529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 6529
aattatttgc aaatcaaaaa                                                   20


<210> 6530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6530
atgttagtca gtgaaataaa                                                   20


<210> 6531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 6531
tgtatatcaa attgtttctc                                                   20


<210> 6532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 6532
ttcatctaaa attttatgag                                                   20


<210> 6533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 6533
cagaaaagga gatcaatctt                                                   20


<210> 6534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 6534
ttaatgaatt atattgtttt                                                   20


<210> 6535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 6535
atcaatgcac taattagact                                                   20


<210> 6536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 6536
tagagctgga aattaaagtg                                                   20


<210> 6537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 6537
gggaacttag aaacttccag                                                   20


<210> 6538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 6538
agtttgagtc ttctgggaac                                                   20


<210> 6539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 6539
atccaatgtt tatgtaaagt                                                   20


<210> 6540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 6540
cttatccaat aatttgcccc                                                   20


<210> 6541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 6541
tgtttttatt tcctcaatca                                                   20


<210> 6542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6542
ctcttgcctc aaaataagag                                                   20


<210> 6543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 6543
atcactcttg cctcaaaata                                                   20


<210> 6544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6544
cacattagtg aaaccaccca                                                   20


<210> 6545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 6545
gttttagtta tatttgatgt                                                   20


<210> 6546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 6546
ctactcaaga ggctgaggca                                                   20


<210> 6547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 6547
aaaattaaat gaagtatgaa                                                   20


<210> 6548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 6548
tctctgctac ctgaaaggta                                                   20


<210> 6549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAT

<400> 6549
attggtctac aagagctggg                                                   20


<210> 6550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 6550
aagcatgggc ttgtcagaat                                                   20


<210> 6551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 6551
gactgagaag catgggcttg                                                   20


<210> 6552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CGAGAAT

<400> 6552
ctacttgtga ggctgaggca                                                   20


<210> 6553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 6553
accaagaggc caaaatagat                                                   20


<210> 6554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6554
tggcgtttct tccgtgatgt                                                   20


<210> 6555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 6555
ctatcaatga atgattggtc                                                   20


<210> 6556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 6556
acaaaacaat accccttgct                                                   20


<210> 6557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 6557
tccaaactga ggccagtata                                                   20


<210> 6558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 6558
ttcaaaaaac ttaaactctt                                                   20


<210> 6559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 6559
gacttaaaat tctaggataa                                                   20


<210> 6560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 6560
aacatgtatg gcctgctcct                                                   20


<210> 6561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 6561
gtgtccatgt tacagagatt                                                   20


<210> 6562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 6562
tttgcatgca cactaaaatg                                                   20


<210> 6563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 6563
tggaatctac tcactaactc                                                   20


<210> 6564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAT

<400> 6564
ttcccagatc aatggaacca                                                   20


<210> 6565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 6565
tattttacag gatggtgtag                                                   20


<210> 6566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 6566
gttactcata aagctctggg                                                   20


<210> 6567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 6567
ttcacatgtc atttagcaaa                                                   20


<210> 6568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 6568
gataaagttg taacttaata                                                   20


<210> 6569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 6569
attaatacaa attcatagat                                                   20


<210> 6570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 6570
gaatttaatg tggtacccat                                                   20


<210> 6571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 6571
ctaggtgata ataatagcat                                                   20


<210> 6572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 6572
ataattattt actccagtta                                                   20


<210> 6573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 6573
aaagcctatt ctatagtttt                                                   20


<210> 6574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 6574
aagggcctgg tcttaacttc                                                   20


<210> 6575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 6575
ccaggccaat aattcttttt                                                   20


<210> 6576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 6576
ttaaaagttg ttaccagctc                                                   20


<210> 6577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 6577
taaagtcaga attctgcaaa                                                   20


<210> 6578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 6578
tttcatgaat ttagctaaag                                                   20


<210> 6579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 6579
gttaatgctc tcttaaacag                                                   20


<210> 6580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 6580
ccaagaaaac attgaatgtc                                                   20


<210> 6581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 6581
ttgaatactt aatgcattcc                                                   20


<210> 6582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 6582
ttctatataa aggtattctc                                                   20


<210> 6583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 6583
aaatatggtg atgcctactg                                                   20


<210> 6584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 6584
tttaaagaaa tgaagataat                                                   20


<210> 6585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6585
aacaacagat gattgagttt                                                   20


<210> 6586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6586
aggtcctatt tataatagca                                                   20


<210> 6587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 6587
aaattgatac ttccctttta                                                   20


<210> 6588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 6588
gcaatcaaag ggaaaaccat                                                   20


<210> 6589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 6589
atttctactc aagcagtata                                                   20


<210> 6590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 6590
cattctaggc tctgctcctt                                                   20


<210> 6591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 6591
ccctgaatga ttgcaagaga                                                   20


<210> 6592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 6592
cccagaaatc taaatcatgt                                                   20


<210> 6593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 6593
ttgtagagac ctcaaggggc                                                   20


<210> 6594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 6594
ttacctttta aaaagaatct                                                   20


<210> 6595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 6595
cttgaggcat taccttttaa                                                   20


<210> 6596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 6596
acattaaaac ttagacaaca                                                   20


<210> 6597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAT

<400> 6597
cccataatta gaatgtgagc                                                   20


<210> 6598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 6598
aaagttttag ttgcccataa                                                   20


<210> 6599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6599
tttctctgct agcaatagac                                                   20


<210> 6600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 6600
ttgacctcat tatttcacca                                                   20


<210> 6601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 6601
gtgccctagg tagaagattc                                                   20


<210> 6602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 6602
gtaagttttc atgttattgg                                                   20


<210> 6603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 6603
atgatactat aggacctggc                                                   20


<210> 6604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 6604
ctttgcttct cttcttttca                                                   20


<210> 6605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 6605
gtgggtagta ttagtagtta                                                   20


<210> 6606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 6606
ttctatttat attttcaata                                                   20


<210> 6607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 6607
aaaaaaactg aatattcagt                                                   20


<210> 6608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 6608
ttaatgaatg gtcatcctct                                                   20


<210> 6609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 6609
attacttttt taccaagctg                                                   20


<210> 6610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 6610
aatttttgag aaagctattt                                                   20


<210> 6611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 6611
tagataaaac atataatttt                                                   20


<210> 6612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAT

<400> 6612
tcatagaaaa ctattttatt                                                   20


<210> 6613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 6613
gatttagagg caatattctc                                                   20


<210> 6614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 6614
ggggcaggaa tctctgccaa                                                   20


<210> 6615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 6615
atacataatc agatcagtct                                                   20


<210> 6616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 6616
gaagtaatat tactcattga                                                   20


<210> 6617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 6617
catgctttct tagtacacat                                                   20


<210> 6618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAT

<400> 6618
attgattata aaagtaaaat                                                   20


<210> 6619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 6619
gcctgaccca ctgcaagaaa                                                   20


<210> 6620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 6620
cctttctgcc tgacccactg                                                   20


<210> 6621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 6621
ttcaattttt aaatagtaga                                                   20


<210> 6622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 6622
ttgcttgcat ttaaggaaaa                                                   20


<210> 6623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 6623
tgccacctca ccccctatac                                                   20


<210> 6624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 6624
tcaatcaaga aatgctaatt                                                   20


<210> 6625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 6625
ttaaataaaa ataagtcaat                                                   20


<210> 6626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 6626
gtttttttca ggttgtttcc                                                   20


<210> 6627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 6627
ttttttaaaa gcactcttct                                                   20


<210> 6628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 6628
cttctgctta ttactacact                                                   20


<210> 6629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 6629
tagaccagac cttacagtat                                                   20


<210> 6630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAT

<400> 6630
aattttctat gactctctgc                                                   20


<210> 6631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 6631
ccatttttaa tctgcaaaaa                                                   20


<210> 6632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 6632
ttagaaaata tatatgaaaa                                                   20


<210> 6633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 6633
gttaattttt acttattgaa                                                   20


<210> 6634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 6634
attcctttat gaaaatgtca                                                   20


<210> 6635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6635
tatccaatac ccaggtagag                                                   20


<210> 6636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 6636
tttatatcca atacccaggt                                                   20


<210> 6637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 6637
ctctcaggac aatgtattaa                                                   20


<210> 6638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 6638
tcatgactta ttatgttatt                                                   20


<210> 6639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 6639
tgatgaaatt ggcaagtgac                                                   20


<210> 6640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAT

<400> 6640
aagtaaaact gattttactt                                                   20


<210> 6641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 6641
tactacatgc catagaaagg                                                   20


<210> 6642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 6642
taatcattat actacatgcc                                                   20


<210> 6643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 6643
tgactgcgat tctaaaagat                                                   20


<210> 6644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 6644
tttgagaggt ggatgcaaaa                                                   20


<210> 6645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 6645
cctgggaaac caatcctgag                                                   20


<210> 6646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 6646
aaagataaat cttaaggaaa                                                   20


<210> 6647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 6647
attaagaata cactgatgga                                                   20


<210> 6648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 6648
tagatggtta ttgatacaat                                                   20


<210> 6649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 6649
attacaattc aacccacaac                                                   20


<210> 6650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 6650
aaactcagtg gcttacaaca                                                   20


<210> 6651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 6651
ctatgctcta agcactgtgc                                                   20


<210> 6652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 6652
aatactcttt tcactgtttc                                                   20


<210> 6653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 6653
tgttatctca aaggtaccca                                                   20


<210> 6654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 6654
gagatagtca gtgtcagaat                                                   20


<210> 6655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 6655
ctctgaagag atagtcagtg                                                   20


<210> 6656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 6656
ttttacagta aaacctctta                                                   20


<210> 6657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAT

<400> 6657
tagacagtta aaaatacact                                                   20


<210> 6658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 6658
ggtttctcaa cagagtttat                                                   20


<210> 6659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6659
tttttaaatg gtctcctcac                                                   20


<210> 6660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 6660
acaaagctac agtgagatag                                                   20


<210> 6661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 6661
aggtacaaag ctacagtgag                                                   20


<210> 6662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 6662
ggttgtcata gaagtagata                                                   20


<210> 6663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 6663
ttaagtgaaa tcagccaggc                                                   20


<210> 6664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 6664
aattgaacgc cattcagcca                                                   20


<210> 6665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 6665
atgcataaag aaaatgtaca                                                   20


<210> 6666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6666
tcgtaaataa ataaatgcat                                                   20


<210> 6667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 6667
gttgaagaga tacagtaaac                                                   20


<210> 6668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 6668
ggttctttaa aaaattaaaa                                                   20


<210> 6669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 6669
gaatccttac acactgattg                                                   20


<210> 6670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 6670
tataagtgtt taaaggatat                                                   20


<210> 6671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6671
gatatttctc aaaagaagac                                                   20


<210> 6672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 6672
atagagtgaa gagataacct                                                   20


<210> 6673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 6673
aaaactacac aactattaga                                                   20


<210> 6674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 6674
aaactgaata gccacatgca                                                   20


<210> 6675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 6675
aggttccaag tacctataat                                                   20


<210> 6676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 6676
aatacataag aatagagagc                                                   20


<210> 6677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 6677
cagacacaca gagcaataca                                                   20


<210> 6678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 6678
tataaagcta tagtaaccaa                                                   20


<210> 6679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 6679
aaataccagt gacattcttt                                                   20


<210> 6680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 6680
agatattcca tgttcatgga                                                   20


<210> 6681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 6681
aaaactataa aatattggtg                                                   20


<210> 6682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 6682
agctacaaaa aataaaatac                                                   20


<210> 6683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 6683
aacaacaaat aatctgaaaa                                                   20


<210> 6684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6684
ccagagcaat caggcaagag                                                   20


<210> 6685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 6685
ctagccagag caatcaggca                                                   20


<210> 6686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 6686
ttatcaacaa attaagtata                                                   20


<210> 6687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 6687
atataatcat ctcaatagac                                                   20


<210> 6688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 6688
aaactttcta tattatatca                                                   20


<210> 6689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6689
acagggacac acacacacga                                                   20


<210> 6690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6690
gtaataaaat ctctcctagc                                                   20


<210> 6691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 6691
acttgccaag actgtatcat                                                   20


<210> 6692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 6692
gcctaaattt ggatgcaact                                                   20


<210> 6693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 6693
gcgtgatgaa gatcagtgct                                                   20


<210> 6694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 6694
taagaatgcc actttttaag                                                   20


<210> 6695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 6695
ccactacctt gggatatagt                                                   20


<210> 6696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 6696
gaggcaaatt gaattaccca                                                   20


<210> 6697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 6697
ctacctgaaa atataagaat                                                   20


<210> 6698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 6698
gacaaaccta cctgaaaata                                                   20


<210> 6699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 6699
gggtataaag ccatgcagct                                                   20


<210> 6700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 6700
tgcctggcag acagttgctc                                                   20


<210> 6701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 6701
gtgttcattt cagcttaaag                                                   20


<210> 6702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 6702
atgctcagga ggctgaggca                                                   20


<210> 6703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 6703
tttgttttct ctagctcatg                                                   20


<210> 6704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 6704
aatcttaaat tttaattttt                                                   20


<210> 6705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 6705
tttaatctta cttagctgta                                                   20


<210> 6706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 6706
tagtgaatac agcaaagtgg                                                   20


<210> 6707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAT

<400> 6707
caacctccag attgcagtga                                                   20


<210> 6708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAA

<400> 6708
ttatccgtgt gtgaaaaggt                                                   20


<210> 6709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 6709
ctactgctac agaaatgaac                                                   20


<210> 6710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 6710
ttgattaagg cactactgct                                                   20


<210> 6711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 6711
gaacaaagat ctttagcaca                                                   20


<210> 6712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 6712
tattctagca cgcttcttgg                                                   20


<210> 6713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 6713
taaaactttg cttcaagaga                                                   20


<210> 6714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 6714
agaaataaaa ctttgcttca                                                   20


<210> 6715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 6715
gagaaaaaaa aataattaac                                                   20


<210> 6716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 6716
gacctgcact tctacttcag                                                   20


<210> 6717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 6717
gctgtcttta cttacatctc                                                   20


<210> 6718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAT

<400> 6718
gattcccaga cctccgacct                                                   20


<210> 6719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6719
agacttatga tttttgaagg                                                   20


<210> 6720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 6720
tttgtgatac ccactaggtt                                                   20


<210> 6721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 6721
atggaggaac taccaatatc                                                   20


<210> 6722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 6722
cttggcaaag aaagtataca                                                   20


<210> 6723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6723
tttaattatt aattcttggc                                                   20


<210> 6724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 6724
ttggtgagtg tttcattcgt                                                   20


<210> 6725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6725
ataaaatgct tctgacactt                                                   20


<210> 6726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 6726
tttaagatgc ttattagggc                                                   20


<210> 6727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6727
ttttagtatc ttctctgtga                                                   20


<210> 6728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAT

<400> 6728
ctccgtcgcc tcccaaagtg                                                   20


<210> 6729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 6729
aagaggattc agaagtcagg                                                   20


<210> 6730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 6730
aactttcaag cttacaagca                                                   20


<210> 6731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 6731
ggcagaggtg aatagctgcc                                                   20


<210> 6732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 6732
agtggttaaa ataatcaaaa                                                   20


<210> 6733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 6733
tattgtgtgg ccctgggagc                                                   20


<210> 6734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 6734
gaatagtgat aattttaata                                                   20


<210> 6735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 6735
atctacaatt attaattgca                                                   20


<210> 6736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 6736
agctctttgg taagagctac                                                   20


<210> 6737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 6737
aaattgatga aaatgaaaaa                                                   20


<210> 6738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6738
aggataaatt atcaattcta                                                   20


<210> 6739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 6739
atgtatgaaa gtattagaaa                                                   20


<210> 6740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 6740
tgagaaaatg tatgaaagta                                                   20


<210> 6741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 6741
attttatcta agtgtcggca                                                   20


<210> 6742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 6742
gagtaagaag cttgtggctt                                                   20


<210> 6743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 6743
tttcctgttt tctaatatta                                                   20


<210> 6744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 6744
atttacagga ctaagttaga                                                   20


<210> 6745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 6745
ttactctaac agtagtcaga                                                   20


<210> 6746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 6746
tatagaccta aacatttccc                                                   20


<210> 6747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 6747
acgactgcat ccctgtgaac                                                   20


<210> 6748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 6748
accagttcat ttttagggcc                                                   20


<210> 6749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 6749
agctttaaaa acaactattt                                                   20


<210> 6750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 6750
agtacacacc tcacatattt                                                   20


<210> 6751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 6751
tgtcagatga atctgcagcc                                                   20


<210> 6752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 6752
ctataaacct tgtttcaata                                                   20


<210> 6753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 6753
acagcaagag ttttttctgg                                                   20


<210> 6754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAA

<400> 6754
gtgatttaat agtaattgat                                                   20


<210> 6755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6755
atgactttgc aaaatgaaaa                                                   20


<210> 6756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 6756
taggcacatg aaattcttag                                                   20


<210> 6757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 6757
ggcacgacca atcaaataca                                                   20


<210> 6758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 6758
attaattcct ttaatcctca                                                   20


<210> 6759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 6759
tatctgaata aattgaacac                                                   20


<210> 6760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 6760
agtaattcca gaaatttatc                                                   20


<210> 6761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 6761
tccctcaata aaaagtaatt                                                   20


<210> 6762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 6762
aactatacaa ctttacaaat                                                   20


<210> 6763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 6763
cttgtttgac agactatagc                                                   20


<210> 6764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 6764
catttaagag ttttttcacc                                                   20


<210> 6765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 6765
ctacgagtca ctaagtggtt                                                   20


<210> 6766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 6766
gcttcttatc ttgaaaaaat                                                   20


<210> 6767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 6767
ataatagatc ccatttctat                                                   20


<210> 6768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 6768
atatatagat agatatcagt                                                   20


<210> 6769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAT

<400> 6769
aatggagcag taactctagg                                                   20


<210> 6770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 6770
cagcaaaatg aatggcatta                                                   20


<210> 6771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 6771
ataaagagac cattcacact                                                   20


<210> 6772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 6772
aaatgttcct gagaaccatt                                                   20


<210> 6773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 6773
ttttgaaaga ccttatagtt                                                   20


<210> 6774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 6774
atcacccgag gcagaatgct                                                   20


<210> 6775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAT

<400> 6775
ctaaatgtgt atcacccgag                                                   20


<210> 6776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 6776
agaatcagag gacagcatca                                                   20


<210> 6777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 6777
atgctgagaa attgtcgaaa                                                   20


<210> 6778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 6778
ggagaggaaa agggagatgc                                                   20


<210> 6779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 6779
agaagaaaca gaagaaagaa                                                   20


<210> 6780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6780
aaagaaagaa gaaacagaag                                                   20


<210> 6781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 6781
tgctaaagaa agaagaaaca                                                   20


<210> 6782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 6782
ctctaaaagt gctaaagaaa                                                   20


<210> 6783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6783
aactgagctc taaaagtgct                                                   20


<210> 6784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAT

<400> 6784
atatacaagt attaggagaa                                                   20


<210> 6785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6785
aagcattctg atcattgtgt                                                   20


<210> 6786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 6786
ctttatttcc catgttttta                                                   20


<210> 6787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 6787
acatacatat aaaaagaatg                                                   20


<210> 6788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 6788
aaaattatac atacatataa                                                   20


<210> 6789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 6789
ttatcatgag gaaaaatctt                                                   20


<210> 6790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 6790
ttggaaaatt agaaaataac                                                   20


<210> 6791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 6791
aaaatttaaa ttttggaaaa                                                   20


<210> 6792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 6792
cattttaata atggtaaaaa                                                   20


<210> 6793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 6793
gtttgagaag gcttgtacta                                                   20


<210> 6794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 6794
taagataaaa catgagatat                                                   20


<210> 6795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 6795
atatcatgag gaaaaatctt                                                   20


<210> 6796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAT

<400> 6796
ggaaccaatt ctgggctgag                                                   20


<210> 6797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 6797
atttaaaatt cttcctagag                                                   20


<210> 6798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 6798
aagaagctaa acagaaagaa                                                   20


<210> 6799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 6799
acattgaaga agctaaacag                                                   20


<210> 6800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 6800
gcaaacattg aagaagctaa                                                   20


<210> 6801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 6801
atactactac acttaataat                                                   20


<210> 6802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 6802
tgatgataaa gaaagaaaag                                                   20


<210> 6803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6803
attaatattt gatgataaag                                                   20


<210> 6804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6804
tattattaat atttgatgat                                                   20


<210> 6805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6805
aaaattctat tttaaaaagc                                                   20


<210> 6806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6806
ttatgccaaa aaaaagaaaa                                                   20


<210> 6807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6807
cctgcacgtt atgccaaaaa                                                   20


<210> 6808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 6808
ctcagcaaac taaaacagga                                                   20


<210> 6809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 6809
ttgcagggac atggatgaag                                                   20


<210> 6810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 6810
gaatactatg cagccataaa                                                   20


<210> 6811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6811
ccatcaatga tagactggat                                                   20


<210> 6812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 6812
acagatgctg gagaaaatgt                                                   20


<210> 6813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 6813
gtcagaaaat aacagatgct                                                   20


<210> 6814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 6814
gaatggtgat aattaaaaag                                                   20


<210> 6815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 6815
gagataccat ctcatgccag                                                   20


<210> 6816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 6816
gctcatcatc actggccatt                                                   20


<210> 6817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 6817
ctcagcaaac taatacagga                                                   20


<210> 6818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 6818
aatactatgc agccattaaa                                                   20


<210> 6819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6819
ccatcaatgt taaattgtat                                                   20


<210> 6820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 6820
aattccttaa ggacctagaa                                                   20


<210> 6821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 6821
atagattctg gtgaggctat                                                   20


<210> 6822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 6822
aatggtgatt attaaaaagt                                                   20


<210> 6823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 6823
gagataccat ctcaagtcag                                                   20


<210> 6824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 6824
agctcaacat cagtgatcat                                                   20


<210> 6825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 6825
ctcttgtctg attgccctgg                                                   20


<210> 6826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 6826
gatgatcggg ttttctaaat                                                   20


<210> 6827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 6827
tccagctttg ttctttttgc                                                   20


<210> 6828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 6828
attacattat acaattatta                                                   20


<210> 6829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6829
ggtcaccttt actcaaaatt                                                   20


<210> 6830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CGAGAAT

<400> 6830
ttttatattt actttatttc                                                   20


<210> 6831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 6831
ataacaatga ttcacttttc                                                   20


<210> 6832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 6832
taggaggttt tttatttatt                                                   20


<210> 6833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 6833
ttaccaacag gtgagtacca                                                   20


<210> 6834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAA

<400> 6834
gtacacctgt gtgaaaattg                                                   20


<210> 6835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 6835
ttcaatattg tccccctata                                                   20


<210> 6836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 6836
cacagacaga cttatgcctt                                                   20


<210> 6837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 6837
ctattccaag aattatacag                                                   20


<210> 6838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 6838
ttattgactc taatctattc                                                   20


<210> 6839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6839
aaccagtcca ccaattttag                                                   20


<210> 6840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 6840
gaaaaaccag tccaccaatt                                                   20


<210> 6841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 6841
ttgctgttcc cagaagaatc                                                   20


<210> 6842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 6842
ggataaggtt gctgttccca                                                   20


<210> 6843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 6843
ttttaagaat attgtatata                                                   20


<210> 6844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 6844
ggacttgggt acacatattt                                                   20


<210> 6845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 6845
gaaggtagaa aatgttactt                                                   20


<210> 6846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 6846
gtcatataaa tcttaagaag                                                   20


<210> 6847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 6847
taaaggctga aagagaagga                                                   20


<210> 6848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 6848
actgttcaaa ttcttcttca                                                   20


<210> 6849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 6849
aatatttgag ggagaatata                                                   20


<210> 6850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 6850
attatcaata aatatttgag                                                   20


<210> 6851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 6851
ttagtttaaa tatcatctcc                                                   20


<210> 6852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 6852
acgtcctaat gatgcatttc                                                   20


<210> 6853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 6853
gaatgaaaag taagataatt                                                   20


<210> 6854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAT

<400> 6854
cattgtcatc tcctcaacac                                                   20


<210> 6855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 6855
ttactactaa aaattagcac                                                   20


<210> 6856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 6856
taggaagtca ggttcttata                                                   20


<210> 6857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 6857
atagaagcaa cattcaaatc                                                   20


<210> 6858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 6858
cctgtttttg agcagctagt                                                   20


<210> 6859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 6859
ataatttaat gtctagttgt                                                   20


<210> 6860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 6860
cgtgattcat tctttatctt                                                   20


<210> 6861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 6861
aatattttca tctttcccac                                                   20


<210> 6862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAT

<400> 6862
aattaattta aaaacttcac                                                   20


<210> 6863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAT

<400> 6863
agttgtcttt ctgagcaagg                                                   20


<210> 6864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 6864
tctaatattt gacatttaat                                                   20


<210> 6865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 6865
agctaaatgt gcagtattat                                                   20


<210> 6866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 6866
agaacttggt tgatagatca                                                   20


<210> 6867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 6867
tatatggtca tatcagggca                                                   20


<210> 6868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 6868
aaattctaca gatgatttga                                                   20


<210> 6869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 6869
cctgagagtg caaatgagga                                                   20


<210> 6870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAT

<400> 6870
aaatttggct ataaagggaa                                                   20


<210> 6871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 6871
atatgtgtag acaattctcc                                                   20


<210> 6872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 6872
acaggggtga aaagaagagg                                                   20


<210> 6873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 6873
gtaagtggta gggttcaagg                                                   20


<210> 6874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 6874
gaagtcatca gagaatttct                                                   20


<210> 6875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 6875
taagtaacag ggaagtcatc                                                   20


<210> 6876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6876
aaggagtaag gatgatgaag                                                   20


<210> 6877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 6877
gatcaaggag taaggatgat                                                   20


<210> 6878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 6878
gtagaaacag atgtgcttgt                                                   20


<210> 6879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 6879
ccaagagaag aaaacatatt                                                   20


<210> 6880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 6880
tataaataat gaagccaaga                                                   20


<210> 6881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 6881
gaggacccag aaaagaacac                                                   20


<210> 6882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 6882
attcaggtag aaaagaggac                                                   20


<210> 6883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 6883
ctctgacatt tagaattcag                                                   20


<210> 6884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 6884
aagatctaca actctgacat                                                   20


<210> 6885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 6885
cctgatattt ttaagtagat                                                   20


<210> 6886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6886
aattccagag caatcagcaa                                                   20


<210> 6887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 6887
agagaattgg agatttaagt                                                   20


<210> 6888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 6888
tccaggtgga tatataatat                                                   20


<210> 6889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 6889
gagtgatggc agagaaatga                                                   20


<210> 6890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 6890
gtttcatcta gagtgatggc                                                   20


<210> 6891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 6891
ttgcttctct catctaggca                                                   20


<210> 6892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 6892
gggtagatgg tagatgggaa                                                   20


<210> 6893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAA

<400> 6893
gaatggcaac agagaaagta                                                   20


<210> 6894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 6894
gagaaaggaa gaatggcaac                                                   20


<210> 6895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 6895
cgtggtttgg taagagaaag                                                   20


<210> 6896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 6896
aacagcagcg tggtttggta                                                   20


<210> 6897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 6897
taaagggagg gtatgggttt                                                   20


<210> 6898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 6898
ggggggtgct gcttcaatta                                                   20


<210> 6899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 6899
ctactcagga ggctgaggca                                                   20


<210> 6900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6900
tacaaaaaaa gaagaaaaaa                                                   20


<210> 6901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 6901
taaaaaataa tacaaaaaaa                                                   20


<210> 6902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 6902
tacaagaata tactaataga                                                   20


<210> 6903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 6903
gctgagacag ctacttgtta                                                   20


<210> 6904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 6904
atgagcagga gtatttatag                                                   20


<210> 6905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6905
ggttttctta acctttgtta                                                   20


<210> 6906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 6906
gaaacttatt tccaatggat                                                   20


<210> 6907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 6907
gaaaaaaata gaagccttaa                                                   20


<210> 6908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 6908
aaaagactat aaataaaatg                                                   20


<210> 6909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 6909
agatatcaaa gtttagttca                                                   20


<210> 6910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 6910
aaaaaagaat tattttctct                                                   20


<210> 6911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 6911
cctaatttct atatcataaa                                                   20


<210> 6912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 6912
tttcaaagct attcaaatat                                                   20


<210> 6913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 6913
agtgaagaag actttagaag                                                   20


<210> 6914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 6914
cacttgaaaa taatgaaaca                                                   20


<210> 6915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 6915
ttgacaacct aggtattctt                                                   20


<210> 6916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6916
gggctgactt tgatcttttg                                                   20


<210> 6917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 6917
tttaattcta caggtattta                                                   20


<210> 6918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 6918
ttaaaataga agccccaaac                                                   20


<210> 6919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 6919
gagaagttta acaaccccaa                                                   20


<210> 6920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 6920
ttccatctgc tacctgctgc                                                   20


<210> 6921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 6921
tcttttccca aatgtattta                                                   20


<210> 6922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 6922
ttgcaagagg cttctgtgta                                                   20


<210> 6923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 6923
atgtcttcca gtggttaatt                                                   20


<210> 6924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 6924
agatgctaca gtgttttctc                                                   20


<210> 6925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 6925
tatgatatta acctgctaga                                                   20


<210> 6926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 6926
aaaatagtct acaagctcat                                                   20


<210> 6927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 6927
ttctcctttc agtcctctaa                                                   20


<210> 6928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 6928
cttcaatata acactgccat                                                   20


<210> 6929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6929
cacagttatt gttactggtg                                                   20


<210> 6930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6930
attagtatta taactaaaat                                                   20


<210> 6931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 6931
gaatggctac aataacattt                                                   20


<210> 6932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 6932
aagtcatctt cctgccaacc                                                   20


<210> 6933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 6933
ctgataaccc tatataaaat                                                   20


<210> 6934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 6934
acggtgagaa atgcttattg                                                   20


<210> 6935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 6935
gacttacctc ctgaatacgg                                                   20


<210> 6936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 6936
ccatgtcaat acaattgcag                                                   20


<210> 6937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAA

<400> 6937
caaaccatgt caatacaatt                                                   20


<210> 6938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 6938
cttaacatgg tgcaggagag                                                   20


<210> 6939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 6939
tctgaatggc aggggaggcc                                                   20


<210> 6940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6940
cctgagactg ggtaatttat                                                   20


<210> 6941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 6941
aatcacttaa aagtttttaa                                                   20


<210> 6942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 6942
gtagtttttt ccagttctgt                                                   20


<210> 6943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 6943
ttattcttgt gatagtttac                                                   20


<210> 6944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 6944
gttcaattcc cacctatgag                                                   20


<210> 6945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 6945
tatatatata tataggatat                                                   20


<210> 6946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAT

<400> 6946
agtgaataac catatcatga                                                   20


<210> 6947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6947
tcaaaggaac ccaaagaaga                                                   20


<210> 6948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 6948
gaaaatcaaa ggaacccaaa                                                   20


<210> 6949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6949
cattgaacaa cgcattgctg                                                   20


<210> 6950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 6950
gggaatttag gaaaatttac                                                   20


<210> 6951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 6951
ttgaagtgac agcagaggat                                                   20


<210> 6952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6952
gttgcttctg attgataagc                                                   20


<210> 6953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 6953
tggtggaaat agcaagagaa                                                   20


<210> 6954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 6954
cagatgtggt ggaaatagca                                                   20


<210> 6955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 6955
taatcattca gaaaatctct                                                   20


<210> 6956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 6956
taattatatt atttaatcat                                                   20


<210> 6957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 6957
taactatatt atttaattat                                                   20


<210> 6958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 6958
ataattatat tctttactat                                                   20


<210> 6959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 6959
ataattatat tatttactat                                                   20


<210> 6960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 6960
ataattatat tatttactat                                                   20


<210> 6961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 6961
tattaataat tatttactat                                                   20


<210> 6962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 6962
gaattatatt atttaattat                                                   20


<210> 6963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 6963
aatttatcgt tcagaaaatc                                                   20


<210> 6964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 6964
agcaaatgct aatttatcgt                                                   20


<210> 6965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 6965
actagaagaa tatattatag                                                   20


<210> 6966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 6966
ggtctaacag ccttctacta                                                   20


<210> 6967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 6967
aacagcctta ttgcaaatat                                                   20


<210> 6968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 6968
tccagtgaac acatgaatga                                                   20


<210> 6969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 6969
ttctcacttt aaatcagaag                                                   20


<210> 6970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 6970
cccctaatgt tcaagtaaag                                                   20


<210> 6971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 6971
cataacttac tctttacctt                                                   20


<210> 6972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 6972
acaatcatca ttatgtagtt                                                   20


<210> 6973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 6973
atggtaccct ccagttgaat                                                   20


<210> 6974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 6974
agaggagaat aggaatattg                                                   20


<210> 6975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 6975
ttgggggaga cagagacaga                                                   20


<210> 6976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 6976
ccatttaaat atttactcca                                                   20


<210> 6977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 6977
agtattcatt ttcactttta                                                   20


<210> 6978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 6978
gtatattttc tttcttctgg                                                   20


<210> 6979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 6979
aaattgtaaa ttaaacatga                                                   20


<210> 6980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 6980
gtgagtgggt aagatagtaa                                                   20


<210> 6981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 6981
actataggaa atcttagata                                                   20


<210> 6982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 6982
catagaaaat aagaaagagt                                                   20


<210> 6983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 6983
gtgtctgcat acatagaaaa                                                   20


<210> 6984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 6984
atatgtgtgt gtctgcatac                                                   20


<210> 6985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 6985
ctttgactgg aaagatgtgt                                                   20


<210> 6986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6986
atctgtgact tctctgctag                                                   20


<210> 6987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 6987
agaaatctgt gacttctctg                                                   20


<210> 6988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 6988
atctacatca catatttgcc                                                   20


<210> 6989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 6989
ataatctatt aatatttatg                                                   20


<210> 6990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAT

<400> 6990
tcacaaagca tgacctttac                                                   20


<210> 6991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 6991
tatagaacgt ttctagcacc                                                   20


<210> 6992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 6992
ttaaaattct cctaaaatat                                                   20


<210> 6993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 6993
gttaatgctc taaactttca                                                   20


<210> 6994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 6994
tgataatagg ttgtctgata                                                   20


<210> 6995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 6995
aattttgaat tttcttatac                                                   20


<210> 6996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 6996
tatggctatt tacacgttct                                                   20


<210> 6997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 6997
gtgtcagatg gtcccttgaa                                                   20


<210> 6998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 6998
tgttcagtat tcatctaagc                                                   20


<210> 6999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 6999
acatctcaaa gctcactatg                                                   20


<210> 7000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 7000
atgaatgatg cttaaaatgt                                                   20


<210> 7001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 7001
catgcctcaa aagaacttgg                                                   20


<210> 7002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7002
ctccaaatta agaagaaact                                                   20


<210> 7003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7003
ttacaaaagc tccaaattaa                                                   20


<210> 7004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 7004
atgcctcaac atttttagaa                                                   20


<210> 7005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 7005
tcctaaatgc ctcaacattt                                                   20


<210> 7006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7006
tgaaatgatg ggaattttct                                                   20


<210> 7007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7007
agcaatattc aatgaataaa                                                   20


<210> 7008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 7008
ctgcttccaa tatttgactt                                                   20


<210> 7009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 7009
catactctaa ctgagccaca                                                   20


<210> 7010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 7010
ttatctggga gatattttta                                                   20


<210> 7011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7011
tagtccctct aatcaagatt                                                   20


<210> 7012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7012
tattttcctg ctccttgaaa                                                   20


<210> 7013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7013
tattttcctg ctccttgaaa                                                   20


<210> 7014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 7014
gttctgattc tatggtgcct                                                   20


<210> 7015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 7015
gagtataggt taggtatttt                                                   20


<210> 7016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 7016
attattacct ttatttaata                                                   20


<210> 7017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7017
cctcccaggc atgattactt                                                   20


<210> 7018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7018
tgacccagga gagtgcattt                                                   20


<210> 7019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7019
gttaaattgt acttattcta                                                   20


<210> 7020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 7020
ctcacagttc ctaaagtaac                                                   20


<210> 7021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 7021
gtgttcagag ctcagtaaaa                                                   20


<210> 7022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 7022
ctttatcttg ttattgacat                                                   20


<210> 7023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 7023
aggtatttag attagtaaaa                                                   20


<210> 7024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7024
tctaatatgc tctcataaaa                                                   20


<210> 7025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7025
taactatggc ttactttgat                                                   20


<210> 7026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 7026
ttgtgcagcc acaaaatctt                                                   20


<210> 7027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 7027
ataagacaga aattctcaag                                                   20


<210> 7028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 7028
tttattttta tcaaaataag                                                   20


<210> 7029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7029
tgagtgagac cttgtgttta                                                   20


<210> 7030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 7030
agtaagataa aacaagataa                                                   20


<210> 7031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7031
agtgtaccta gcaccttgtt                                                   20


<210> 7032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAT

<400> 7032
aaacacagaa ttccttcact                                                   20


<210> 7033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 7033
accaatactg ggatgaaaac                                                   20


<210> 7034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 7034
aattctctca acttgagttt                                                   20


<210> 7035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 7035
acaaataatg gtaagggatt                                                   20


<210> 7036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7036
ttgaaagtca aaataagatt                                                   20


<210> 7037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7037
gatggtgttt tctacacaac                                                   20


<210> 7038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7038
ttaatctttt gtagtttaat                                                   20


<210> 7039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7039
aagactagac aagtacagga                                                   20


<210> 7040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 7040
gcatccttta aaatttttaa                                                   20


<210> 7041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 7041
acttgaggtt aaaaaaatct                                                   20


<210> 7042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 7042
gaatgggata tgggggcaat                                                   20


<210> 7043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 7043
tgaaaaacag gtagagtggc                                                   20


<210> 7044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 7044
aatattcaat tttcaagaaa                                                   20


<210> 7045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 7045
tgtgtacaat attcaatttt                                                   20


<210> 7046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 7046
tagtaaataa aaacaaacaa                                                   20


<210> 7047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7047
caaaaatgaa gggaagtcct                                                   20


<210> 7048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 7048
caaagtaaag ggaagatcaa                                                   20


<210> 7049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7049
cactatactc agttgtggta                                                   20


<210> 7050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7050
aaaaacaagt tgtaaaactc                                                   20


<210> 7051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7051
tatcttacaa ctcatatgtg                                                   20


<210> 7052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 7052
aaggatgagc aataaaataa                                                   20


<210> 7053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7053
gaaggaagat tggatattgg                                                   20


<210> 7054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 7054
caagttcaaa gtaaagggca                                                   20


<210> 7055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7055
aaagatattg attacaagca                                                   20


<210> 7056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7056
attaattttc aagtgattca                                                   20


<210> 7057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAA

<400> 7057
agttttggac tgtggatatt                                                   20


<210> 7058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 7058
gtgatttcat ttttaaaaac                                                   20


<210> 7059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7059
tataataaaa tataatttta                                                   20


<210> 7060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 7060
taactccacc tggaggtagg                                                   20


<210> 7061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 7061
aaaaacattt ccatttatgg                                                   20


<210> 7062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7062
tcatcgagga aattttcaga                                                   20


<210> 7063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 7063
gccaatcatc gaggaaattt                                                   20


<210> 7064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7064
atgaatgttg aatggagaaa                                                   20


<210> 7065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 7065
ctcattaatg aatgttgaat                                                   20


<210> 7066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 7066
tttgatcctt taatggaaca                                                   20


<210> 7067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 7067
tgaaatgtat tttatccctt                                                   20


<210> 7068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7068
cgaaatcata ctttaattct                                                   20


<210> 7069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 7069
ctctttaata gatgcagttg                                                   20


<210> 7070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 7070
tctgttcaga ctctactaat                                                   20


<210> 7071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 7071
attgccagta aagaaattgt                                                   20


<210> 7072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7072
tcagtaaagt aattgccagt                                                   20


<210> 7073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 7073
agatgagtct tcagaaacaa                                                   20


<210> 7074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 7074
cacgccttcc agatgagtct                                                   20


<210> 7075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 7075
atctactgcc gtaataaaaa                                                   20


<210> 7076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7076
aataaaatca catcttattg                                                   20


<210> 7077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7077
tgatttcctc aacttgtacc                                                   20


<210> 7078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7078
acaatggatg tgcattaaac                                                   20


<210> 7079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 7079
catcattatt tatcattaac                                                   20


<210> 7080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7080
ttttcatatt caagaaagga                                                   20


<210> 7081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 7081
ctgtgcttat ttttcatatt                                                   20


<210> 7082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 7082
cattcattag gaaataatga                                                   20


<210> 7083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAA

<400> 7083
agggaacacc aaaagcacag                                                   20


<210> 7084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 7084
aaaatgttta cctctacaaa                                                   20


<210> 7085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAT

<400> 7085
ttggtggata tattggaagc                                                   20


<210> 7086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7086
atcctcctag tttcctctca                                                   20


<210> 7087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 7087
tggcttgcac ttttcagcct                                                   20


<210> 7088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 7088
ctgaaaagac tcccatacaa                                                   20


<210> 7089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7089
ttaatataaa gagcaccgaa                                                   20


<210> 7090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7090
aattgtcagg tcacgaaaga                                                   20


<210> 7091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7091
tgcccaattg tcaggtcacg                                                   20


<210> 7092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 7092
gatttccgaa gagcagtgtg                                                   20


<210> 7093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7093
ctattacttg tttgtgcctt                                                   20


<210> 7094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 7094
gtaagatcta aattaaaaat                                                   20


<210> 7095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 7095
atatcattta ttggggtgaa                                                   20


<210> 7096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 7096
aatttcaaag agaaatgtca                                                   20


<210> 7097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7097
atagtagaat taaatttcaa                                                   20


<210> 7098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 7098
atatgctacc tctctagata                                                   20


<210> 7099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7099
tgttaaaatg gcatgttttg                                                   20


<210> 7100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 7100
caagaatcag tagtagtagt                                                   20


<210> 7101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 7101
tttttaaaaa attcaaaaac                                                   20


<210> 7102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7102
agaaaaaaag aaagagaaag                                                   20


<210> 7103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7103
agaaagaaaa aaagaaagag                                                   20


<210> 7104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7104
agaaagaaag aaaaaaagaa                                                   20


<210> 7105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7105
aaagaaagaa agaaagaaaa                                                   20


<210> 7106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7106
aggaaggaaa agaaagaaag                                                   20


<210> 7107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7107
gggaaggaag gaaaagaaag                                                   20


<210> 7108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7108
gagagggaag gaaggaaaag                                                   20


<210> 7109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7109
aggagagagg gaaggaagga                                                   20


<210> 7110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7110
gaaagaaaga aagggaaaga                                                   20


<210> 7111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7111
agaaagaaag aaagaaaggg                                                   20


<210> 7112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7112
aaagaaagaa agaaagaaag                                                   20


<210> 7113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7113
aaagaaagaa agaaagaaag                                                   20


<210> 7114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7114
aaagaaagaa agaaagaaag                                                   20


<210> 7115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7115
aaagaaagaa agaaagaaag                                                   20


<210> 7116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7116
aaagaaagaa agaaagaaag                                                   20


<210> 7117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7117
aaagaaagaa agaaagaaag                                                   20


<210> 7118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7118
aaagaaagaa agaaagaaag                                                   20


<210> 7119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7119
aaagaaagaa agaaagaaag                                                   20


<210> 7120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7120
aaagaaagaa agaaagaaag                                                   20


<210> 7121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7121
aaagaaagaa agaaagaaag                                                   20


<210> 7122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7122
agaaaaagaa agaaagaaag                                                   20


<210> 7123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7123
agaaagaaaa agaaagaaag                                                   20


<210> 7124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7124
agaaagaaag aaaaagaaag                                                   20


<210> 7125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7125
ggaaagaaag aaagaaaaag                                                   20


<210> 7126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7126
gaaaggaaag aaagaaagaa                                                   20


<210> 7127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7127
agaagagaaa ggaaagaaag                                                   20


<210> 7128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7128
agaaagaaga gaaaggaaag                                                   20


<210> 7129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7129
aaaaagaaag aagagaaagg                                                   20


<210> 7130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7130
acactatcaa aaaagaaaga                                                   20


<210> 7131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7131
cacagaaata cactatcaaa                                                   20


<210> 7132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 7132
tgcactacag cctgggtgac                                                   20


<210> 7133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7133
cttggcatat atttgtacat                                                   20


<210> 7134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 7134
tgcagttata aaaataaaat                                                   20


<210> 7135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7135
atcaatgcac ataataatac                                                   20


<210> 7136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 7136
tttccaaagg aaatagttct                                                   20


<210> 7137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7137
aatctcaatg tcacctttgg                                                   20


<210> 7138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 7138
ttcccacagc aactgtgaac                                                   20


<210> 7139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7139
aaagcaatta agaaaataat                                                   20


<210> 7140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7140
gctgttagta aaaaagcaat                                                   20


<210> 7141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 7141
acaaaacaat ataagagaga                                                   20


<210> 7142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAA

<400> 7142
caaacattta tgccacacat                                                   20


<210> 7143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 7143
gactctattc taaacgtgag                                                   20


<210> 7144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7144
tttcaattaa tctgatgttg                                                   20


<210> 7145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 7145
tttagttaat tttacaggct                                                   20


<210> 7146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 7146
gtgctctttt ttcacctcac                                                   20


<210> 7147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 7147
tttttgaaat aaaacattga                                                   20


<210> 7148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 7148
atttaatttt tttctttttc                                                   20


<210> 7149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 7149
gcttgacttt gagatgatgt                                                   20


<210> 7150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 7150
agacatgtta tcacatgcaa                                                   20


<210> 7151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7151
taatctgtta tctcacaagt                                                   20


<210> 7152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7152
aaaagactta gcatttctcc                                                   20


<210> 7153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 7153
aattagatta tttgttgtgg                                                   20


<210> 7154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 7154
aaaggattgt aggtggcttt                                                   20


<210> 7155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CGAGAAA

<400> 7155
aaagcttcca tttagttcct                                                   20


<210> 7156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7156
taattttgtc atgatgtcct                                                   20


<210> 7157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7157
aataacatgt tctaattgtt                                                   20


<210> 7158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAT

<400> 7158
aatttagtag ccattttagt                                                   20


<210> 7159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 7159
ctcaaaagcc cagaggagca                                                   20


<210> 7160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 7160
tttatggcct atggtctttt                                                   20


<210> 7161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7161
acaggttcac taatgaggga                                                   20


<210> 7162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 7162
aggcttttcc aagacaagta                                                   20


<210> 7163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 7163
agagcatctc acatttatta                                                   20


<210> 7164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 7164
agatgtcagc aaattgatgt                                                   20


<210> 7165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7165
aagatcccaa aggagaataa                                                   20


<210> 7166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 7166
aaaaaataaa agatcccaaa                                                   20


<210> 7167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 7167
tgtaggtgta attggaaaca                                                   20


<210> 7168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 7168
aatagctctt tactaagtca                                                   20


<210> 7169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 7169
catgaacttt aaatgcctgt                                                   20


<210> 7170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 7170
ggaaagggtt tagggttgat                                                   20


<210> 7171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7171
atagtacaga taaaagataa                                                   20


<210> 7172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 7172
tcttggactg gctcctgagg                                                   20


<210> 7173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7173
cggccactac tttggaggtt                                                   20


<210> 7174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 7174
ccattgggct aaatatggga                                                   20


<210> 7175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7175
ttctttttaa agtaaggaat                                                   20


<210> 7176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 7176
aataaataaa atgagactat                                                   20


<210> 7177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 7177
ttgtagagag attctaattt                                                   20


<210> 7178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 7178
ggagtagaaa agttttcaaa                                                   20


<210> 7179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 7179
gacaagtcca cgaaccagga                                                   20


<210> 7180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 7180
catgcaggaa taatagaatc                                                   20


<210> 7181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 7181
aaattatcca tgcaggaata                                                   20


<210> 7182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 7182
ttaaaggcag aatgcccaga                                                   20


<210> 7183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAT

<400> 7183
caaagagaaa gctgttaaag                                                   20


<210> 7184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7184
ggtggggaca ttacacacaa                                                   20


<210> 7185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 7185
cagtgggcaa gatgattgac                                                   20


<210> 7186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7186
acccacatct tttgcttgaa                                                   20


<210> 7187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 7187
cctaatggct aactgtgact                                                   20


<210> 7188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 7188
tccaatctaa tcaagaaggg                                                   20


<210> 7189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 7189
cgtgtttctt aagaaacgcc                                                   20


<210> 7190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7190
ttaacattgt acgtgtttct                                                   20


<210> 7191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 7191
taatatttct atacttcagt                                                   20


<210> 7192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 7192
taagaaaaaa ttaacccatt                                                   20


<210> 7193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7193
tcccacaatg ttactgcaac                                                   20


<210> 7194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 7194
agtatcttga tcagtatata                                                   20


<210> 7195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 7195
tggcaacaga atggagcagc                                                   20


<210> 7196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 7196
attatcaatt gttggtggca                                                   20


<210> 7197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7197
gaacttttaa atcttggttt                                                   20


<210> 7198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7198
atttgtgatg ttttaataag                                                   20


<210> 7199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7199
agaaatttgt gatgttttaa                                                   20


<210> 7200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7200
aaagcacaga tcttttttca                                                   20


<210> 7201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 7201
acagacatta gccaccacgc                                                   20


<210> 7202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 7202
gacctttggg gaaattaaac                                                   20


<210> 7203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAA

<400> 7203
aaagggaaca ttatgaggat                                                   20


<210> 7204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 7204
caaagcagac tggagatatg                                                   20


<210> 7205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7205
tgaaggagac aggcgtgatg                                                   20


<210> 7206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 7206
tcttggaaca ctgaaaaatc                                                   20


<210> 7207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 7207
tgttttaatt tttttaatga                                                   20


<210> 7208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAT

<400> 7208
tggggaaaca ggttgtaata                                                   20


<210> 7209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 7209
gatttgtgta atcccaaatt                                                   20


<210> 7210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 7210
agacactgac caaagaagaa                                                   20


<210> 7211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7211
agaaaataat gaatatttca                                                   20


<210> 7212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 7212
acacacaatc ccttggcaaa                                                   20


<210> 7213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7213
aaactggcaa aagaaaaaaa                                                   20


<210> 7214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7214
taaaagatga caaactggca                                                   20


<210> 7215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 7215
catttctagg cctatgtttc                                                   20


<210> 7216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 7216
catgccactg cactccagac                                                   20


<210> 7217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 7217
ctactcagga ggctgaggca                                                   20


<210> 7218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7218
ggatgaccca aacactgaga                                                   20


<210> 7219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 7219
gaggtggatg acccaaacac                                                   20


<210> 7220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7220
agaatagagt catctgcatt                                                   20


<210> 7221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 7221
agtattaata taaggtttat                                                   20


<210> 7222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 7222
ttattcttca aaaataaata                                                   20


<210> 7223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 7223
ctgggaaaca ttgaagagtg                                                   20


<210> 7224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7224
atagggtatt atttgcatga                                                   20


<210> 7225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 7225
gtagctttat acatgctgat                                                   20


<210> 7226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7226
cacaaaagag taggttaaaa                                                   20


<210> 7227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 7227
ccgtactgtg aaactattca                                                   20


<210> 7228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 7228
gcgttacact aggtaacaaa                                                   20


<210> 7229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7229
atcagcagag ttagggtagg                                                   20


<210> 7230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 7230
gaggaatgtt catgtctttt                                                   20


<210> 7231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7231
tgaggagtga ggaaattgaa                                                   20


<210> 7232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7232
gcaagcttta ttcgatggcc                                                   20


<210> 7233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 7233
ttggtattgg agacccaata                                                   20


<210> 7234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 7234
gaaaatgcaa actaaaatga                                                   20


<210> 7235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7235
gatccctgac ctcactcaca                                                   20


<210> 7236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 7236
agactacata cagacagagc                                                   20


<210> 7237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 7237
aaatatttgt attgtatacc                                                   20


<210> 7238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7238
agataaacta ccataaacca                                                   20


<210> 7239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 7239
tataaaacac aggagccact                                                   20


<210> 7240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 7240
acacttatga agtacttgaa                                                   20


<210> 7241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7241
tacaaaccac aaaactgcta                                                   20


<210> 7242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7242
gtagcatctt aaataggttg                                                   20


<210> 7243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 7243
gaaatagaca tagttacata                                                   20


<210> 7244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 7244
attggaagaa aatacgatat                                                   20


<210> 7245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7245
cctacataga tagttcattg                                                   20


<210> 7246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7246
caatcccaat gaaaataaaa                                                   20


<210> 7247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 7247
ctaagaaata ataattattt                                                   20


<210> 7248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7248
tctaccaaat taagcatttc                                                   20


<210> 7249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 7249
tattttaata atcatagaat                                                   20


<210> 7250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 7250
atcacaatat tttaataatc                                                   20


<210> 7251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7251
aggtatacaa aatcaactta                                                   20


<210> 7252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7252
ctgagttgaa agctccctaa                                                   20


<210> 7253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 7253
tttatcaaac ctgatggatt                                                   20


<210> 7254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7254
acaatgtcca caaatgttcc                                                   20


<210> 7255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7255
tccaagagag agcagagaaa                                                   20


<210> 7256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7256
ctttagttcc aagagagagc                                                   20


<210> 7257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 7257
ttttaacaac aacaacagaa                                                   20


<210> 7258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 7258
atatattttt aacaacaaca                                                   20


<210> 7259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7259
tgccccaaaa tggcagaaag                                                   20


<210> 7260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAA

<400> 7260
gaaaattctg ccccaaaatg                                                   20


<210> 7261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 7261
gcctatgcac ttgctttatc                                                   20


<210> 7262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 7262
tgaacaggtc aattcatcag                                                   20


<210> 7263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 7263
agatcaatga tttctactat                                                   20


<210> 7264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7264
aaattgaatt aatgagtaag                                                   20


<210> 7265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7265
aaacaaattg aattaatgag                                                   20


<210> 7266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7266
ttaggagaat tcctgatggg                                                   20


<210> 7267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 7267
ataaatatac tagcaattta                                                   20


<210> 7268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 7268
tttttcccta tgatattttc                                                   20


<210> 7269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 7269
tttaggatgt ataccctaaa                                                   20


<210> 7270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 7270
catccgggtc gtagcatata                                                   20


<210> 7271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 7271
tggacatggg taacataaaa                                                   20


<210> 7272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 7272
ttgatgtatt taaggagaag                                                   20


<210> 7273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 7273
agggagctag ctaaacaact                                                   20


<210> 7274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 7274
gaaaaacaat aaaacaggac                                                   20


<210> 7275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7275
ttaacaggta gactggcaga                                                   20


<210> 7276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 7276
aaatgtggtc tgtatataaa                                                   20


<210> 7277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7277
tcatcaacag ataaaagagt                                                   20


<210> 7278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 7278
atatgatcca gcaattgaaa                                                   20


<210> 7279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7279
aaaggtgttg ttgagaatgt                                                   20


<210> 7280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 7280
aaaaaagtga aaggtgttgt                                                   20


<210> 7281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7281
gaagtttatt ctgaaatgga                                                   20


<210> 7282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 7282
aacagagcga gactcagtct                                                   20


<210> 7283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 7283
cttctcggga ggctgaggca                                                   20


<210> 7284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 7284
ggaaaaaggc cttccccaag                                                   20


<210> 7285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7285
gctaatagaa aacaacaaaa                                                   20


<210> 7286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7286
aaatcatgta attacagcta                                                   20


<210> 7287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 7287
gaaagaaatc ttatatattc                                                   20


<210> 7288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7288
atacacattt cttttatagg                                                   20


<210> 7289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 7289
tgaggtgaga acactaaggc                                                   20


<210> 7290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 7290
gtatctaggc atttaataac                                                   20


<210> 7291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 7291
atgagtaaaa cagggaaaaa                                                   20


<210> 7292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 7292
tcttcttgag agtctatact                                                   20


<210> 7293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7293
aattggaaaa ttgagcctct                                                   20


<210> 7294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 7294
aggattgttc acttggaaat                                                   20


<210> 7295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7295
ctatatcttt ttagttctat                                                   20


<210> 7296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7296
gaaggaaatg gctttaggca                                                   20


<210> 7297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 7297
agagcatcca gagaatgtgg                                                   20


<210> 7298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 7298
gaggatttat gagagcatcc                                                   20


<210> 7299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAT

<400> 7299
atgattgtgt cattttcata                                                   20


<210> 7300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7300
tgcttatgtg agctcagttg                                                   20


<210> 7301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 7301
gtttaaatct gtatcatcta                                                   20


<210> 7302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7302
aaatgtatta aaatatattt                                                   20


<210> 7303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 7303
aagtaatttg taatgcattc                                                   20


<210> 7304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAT

<400> 7304
atacaaaaat atggattctt                                                   20


<210> 7305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAT

<400> 7305
cttcattgtt gacttagctt                                                   20


<210> 7306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7306
gaggaagaag aagaggagaa                                                   20


<210> 7307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 7307
tctctgtggc aaggaaaaaa                                                   20


<210> 7308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7308
gagtacctga tgcttctaca                                                   20


<210> 7309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 7309
aatatggtat ttgatgtaaa                                                   20


<210> 7310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 7310
tatcaacaac aaaactctag                                                   20


<210> 7311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 7311
gttgggaagt tcagttcttt                                                   20


<210> 7312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 7312
gatgttaaga gcaatttaca                                                   20


<210> 7313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 7313
acaaaaatca gaacaagaaa                                                   20


<210> 7314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 7314
attcaagaca aaaatcagaa                                                   20


<210> 7315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAT

<400> 7315
tagtgaaatt cagaaaagat                                                   20


<210> 7316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 7316
taagcacttt atagtgaaat                                                   20


<210> 7317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 7317
agcagataca acctgtgggg                                                   20


<210> 7318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7318
cccctgagca acaggagccc                                                   20


<210> 7319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7319
gttgtgagca aagccctacg                                                   20


<210> 7320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 7320
tatacatata tataaagaaa                                                   20


<210> 7321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7321
ttttatatat acatatatat                                                   20


<210> 7322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7322
gattcttcac tgcatcttcg                                                   20


<210> 7323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 7323
ggaaatttcc tgtttctctt                                                   20


<210> 7324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7324
ccaggacaaa tctcagaagc                                                   20


<210> 7325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 7325
caatagcaca tcttacaagt                                                   20


<210> 7326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 7326
atttgtccag gatatggcac                                                   20


<210> 7327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7327
aaaataaaat tttaaaaata                                                   20


<210> 7328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 7328
ttatatattt gcctaacccc                                                   20


<210> 7329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 7329
gagatgaata agtggaacac                                                   20


<210> 7330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7330
ggaatattat tcagcactgt                                                   20


<210> 7331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7331
cttaaaactc aacaacaaga                                                   20


<210> 7332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 7332
taaagcttaa aactcaacaa                                                   20


<210> 7333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 7333
atgcattata tattccactc                                                   20


<210> 7334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 7334
taacaagaac ctagatatat                                                   20


<210> 7335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7335
aaataaatag ttggaacatg                                                   20


<210> 7336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7336
tagactagga atggcacata                                                   20


<210> 7337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 7337
ttctagggct gccaaaagag                                                   20


<210> 7338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7338
ctgtgcagtg tagtatttaa                                                   20


<210> 7339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 7339
actgtctatt ttttgttctt                                                   20


<210> 7340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7340
ttttctaatc ctatttaatt                                                   20


<210> 7341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 7341
tttattcttc tattttcaca                                                   20


<210> 7342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 7342
ttttgatcaa aaataactcc                                                   20


<210> 7343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 7343
ccatcttcct gagctgtggt                                                   20


<210> 7344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAT

<400> 7344
atttttgttt tcacacaatt                                                   20


<210> 7345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 7345
tactatccct gtgtgaggtc                                                   20


<210> 7346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7346
acaggacagc cactcacaac                                                   20


<210> 7347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 7347
aatatcaaga ttgccaatat                                                   20


<210> 7348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7348
tattgagaaa ctcaggcctt                                                   20


<210> 7349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 7349
aataaatgtc tgattttaat                                                   20


<210> 7350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 7350
catgtatagt ctctctcagg                                                   20


<210> 7351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 7351
cagaaagcac tggcactgta                                                   20


<210> 7352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 7352
actggcactg tataagaatg                                                   20


<210> 7353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 7353
ttgttgagaa gatcctgcaa                                                   20


<210> 7354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7354
tgagaagatc ctgcaaacag                                                   20


<210> 7355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 7355
taaaatcttt gctgaggatt                                                   20


<210> 7356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 7356
gaatttatca tcataataat                                                   20


<210> 7357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 7357
cataataatg gagaaatatt                                                   20


<210> 7358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 7358
atccactctg gctactgtac                                                   20


<210> 7359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 7359
gaatagattt ggaagtgagg                                                   20


<210> 7360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 7360
tatttacatt acattaggtg                                                   20


<210> 7361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 7361
ggattggctt ctggactccc                                                   20


<210> 7362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAT

<400> 7362
tttccccaac tatttctgat                                                   20


<210> 7363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 7363
gaattggttg aatccacaga                                                   20


<210> 7364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7364
accatgagat tagtattcct                                                   20


<210> 7365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 7365
tcctccattt gaagacacag                                                   20


<210> 7366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 7366
ctcctcagcc tcgggaactg                                                   20


<210> 7367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7367
ccttccttaa atgtattgac                                                   20


<210> 7368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 7368
cttcagattc tctttgactt                                                   20


<210> 7369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 7369
aaatttgtaa ggtgctttgc                                                   20


<210> 7370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 7370
tcaagagtag cctaagaaca                                                   20


<210> 7371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7371
tgaagggcca gccataagta                                                   20


<210> 7372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 7372
cagattatgt tctcacatat                                                   20


<210> 7373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 7373
aattatgatg gtatattaga                                                   20


<210> 7374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7374
tagagaagaa ttatattttt                                                   20


<210> 7375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7375
gaagaattat atttttatag                                                   20


<210> 7376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7376
atagcattat ctacaatgtg                                                   20


<210> 7377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 7377
gcctagtatg gcaattattt                                                   20


<210> 7378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7378
tatacttacc catataaaat                                                   20


<210> 7379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7379
tcttctcctc attttataga                                                   20


<210> 7380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7380
agttgaggcc catataggtt                                                   20


<210> 7381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 7381
cagctttccc atctgtaaaa                                                   20


<210> 7382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 7382
tactccatgt ggttgtaagg                                                   20


<210> 7383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7383
tagaatgaga caagctacac                                                   20


<210> 7384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 7384
gaaattagaa caatgacaat                                                   20


<210> 7385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 7385
gaacaatgac aatacagaat                                                   20


<210> 7386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 7386
ccaatttgct actaaaaatg                                                   20


<210> 7387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 7387
acaaaccttg atgtggattt                                                   20


<210> 7388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 7388
ctatggttat tctaactgaa                                                   20


<210> 7389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7389
catagatcta tgaaatttgt                                                   20


<210> 7390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 7390
ctggtcactt aaaaaagttt                                                   20


<210> 7391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7391
atatattttt gaaatgctaa                                                   20


<210> 7392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7392
aaggcaatgt aaaaacatta                                                   20


<210> 7393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7393
gaatgaacct aagatggtat                                                   20


<210> 7394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7394
tgtgcatgaa taactttata                                                   20


<210> 7395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 7395
ggcaaaatat atttcacatc                                                   20


<210> 7396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 7396
gtggcaagag agcaagttgg                                                   20


<210> 7397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7397
gatgactaaa caatactgca                                                   20


<210> 7398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 7398
ttgaggagtg taatatgtac                                                   20


<210> 7399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7399
gaacaaaaag ggatatgaaa                                                   20


<210> 7400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 7400
aagatgaatg aaaaacattt                                                   20


<210> 7401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 7401
taaattggtt ctgatgcaat                                                   20


<210> 7402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 7402
aaatttaagc acctcaaaat                                                   20


<210> 7403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7403
agagttctct tacgattctt                                                   20


<210> 7404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CGAGAAT

<400> 7404
gttagtgact gcactgcctt                                                   20


<210> 7405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 7405
tttcttccat ctgtgaacga                                                   20


<210> 7406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 7406
atgatgatat aactaacaaa                                                   20


<210> 7407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 7407
acagtcgggt ggcttactgt                                                   20


<210> 7408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 7408
atacgtttca atcaaatcag                                                   20


<210> 7409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7409
cctgtatgtg gaggaaaata                                                   20


<210> 7410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7410
gcaattactt aaaaaaggat                                                   20


<210> 7411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7411
aaaggattaa gaaattccaa                                                   20


<210> 7412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 7412
cataatagtg ttttacattt                                                   20


<210> 7413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7413
taagaatgat acctactcac                                                   20


<210> 7414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7414
gcaataccgt taaatgctaa                                                   20


<210> 7415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 7415
atatatagct gaacctatct                                                   20


<210> 7416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7416
tttatgatga ttttttcccc                                                   20


<210> 7417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7417
tttacaaatt tgtgttttgc                                                   20


<210> 7418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAT

<400> 7418
ctatttccac atatttccta                                                   20


<210> 7419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAT

<400> 7419
tctatatgtc ttaatatttt                                                   20


<210> 7420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 7420
taattttctt ccagatgaat                                                   20


<210> 7421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 7421
ctgacttaat aggaatgctt                                                   20


<210> 7422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7422
ttaaaagttt ataattctaa                                                   20


<210> 7423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7423
acaacaacaa aaacaagaag                                                   20


<210> 7424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 7424
taacttcact ttaaattctg                                                   20


<210> 7425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7425
gtataatttc cttctaatag                                                   20


<210> 7426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 7426
ttggggcctg tagtgtaaac                                                   20


<210> 7427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 7427
ctcaagagta aatttgtgtt                                                   20


<210> 7428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7428
atccttggat tttgttctgc                                                   20


<210> 7429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 7429
gattttgttc tgcaaagaaa                                                   20


<210> 7430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 7430
gtaaactttt caagtattat                                                   20


<210> 7431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 7431
agatgtgcat taaaaatgaa                                                   20


<210> 7432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7432
gatgtcttga cctccaaggt                                                   20


<210> 7433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAT

<400> 7433
aaaaataaat gtagttaaaa                                                   20


<210> 7434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7434
ataggttaaa atgtgttaat                                                   20


<210> 7435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 7435
tcttaaataa ttacatatgt                                                   20


<210> 7436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7436
cttactgtga cttttattgc                                                   20


<210> 7437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 7437
tttattgcta agaaaatttg                                                   20


<210> 7438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7438
caaatattta gaacttttat                                                   20


<210> 7439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 7439
cccattcaca attactacaa                                                   20


<210> 7440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 7440
aaagaggaca caaacaaatg                                                   20


<210> 7441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 7441
aacagaacag aacagaggcc                                                   20


<210> 7442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 7442
ggaaaactgg ctagccatat                                                   20


<210> 7443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7443
ctaaaaccat aaaaacccta                                                   20


<210> 7444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7444
taaagagctt ctgcaaagca                                                   20


<210> 7445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 7445
tcagagtgaa caggcaacct                                                   20


<210> 7446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 7446
aacaggcaac ctacagaatg                                                   20


<210> 7447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAT

<400> 7447
tctgacaaaa gggctaatat                                                   20


<210> 7448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 7448
aaagaactta aacaaattta                                                   20


<210> 7449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7449
gctcatcatc actggtcatc                                                   20


<210> 7450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 7450
gagataccac ctcatgccaa                                                   20


<210> 7451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 7451
acagatgttg gagaggatgt                                                   20


<210> 7452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 7452
aagacagtgt gatgattcct                                                   20


<210> 7453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 7453
gattcctcaa gaatctaaaa                                                   20


<210> 7454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7454
ccatcaataa tagactggat                                                   20


<210> 7455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 7455
gctttgggag ggattactta                                                   20


<210> 7456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7456
cttaaagtat aataataaaa                                                   20


<210> 7457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 7457
acatttctat atctctattt                                                   20


<210> 7458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7458
actttccaat tgattacata                                                   20


<210> 7459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 7459
attagtataa tccatataat                                                   20


<210> 7460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7460
cagacttcat gtcaatgtca                                                   20


<210> 7461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 7461
agaacttgac agaagaagct                                                   20


<210> 7462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 7462
agaagctgga gaaaaactga                                                   20


<210> 7463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7463
ggagaaaact ccaactttga                                                   20


<210> 7464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 7464
atcctggttg tcaatatgat                                                   20


<210> 7465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7465
agattatgaa ttaattcaat                                                   20


<210> 7466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 7466
gataaattga ggtaatgcat                                                   20


<210> 7467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 7467
tagtaaaata gggttggtta                                                   20


<210> 7468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7468
atgcaaagca caaggaacac                                                   20


<210> 7469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7469
ggaaacaaca aaaagggata                                                   20


<210> 7470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7470
aatccgcagt tactgaccct                                                   20


<210> 7471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7471
agatttataa attgcctaaa                                                   20


<210> 7472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7472
atgaggatat caatgaaggg                                                   20


<210> 7473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 7473
tcagtaaaaa ctctggaatt                                                   20


<210> 7474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 7474
atagcagact tgatcaaact                                                   20


<210> 7475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7475
cagacttgat caaactggag                                                   20


<210> 7476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 7476
tggagaaaga atcaacaaac                                                   20


<210> 7477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7477
gctcatcatc actggccatc                                                   20


<210> 7478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 7478
gagataccat ctcataccag                                                   20


<210> 7479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 7479
acaggtgctg gagaggatgt                                                   20


<210> 7480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 7480
gattcctcaa ggatctagaa                                                   20


<210> 7481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7481
ccaacaatga tagactggat                                                   20


<210> 7482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7482
ttatccagtc agtggagcaa                                                   20


<210> 7483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 7483
attatgaaat cacagagaag                                                   20


<210> 7484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7484
catctaaatt caggaaactc                                                   20


<210> 7485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 7485
tactcgggag gctgaggcag                                                   20


<210> 7486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7486
gaaactctat ctcggaaaaa                                                   20


<210> 7487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7487
ctctatctcg gaaaaaaaag                                                   20


<210> 7488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 7488
aaagggaagt ttgaaagcag                                                   20


<210> 7489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7489
agtatatatt caaaatactt                                                   20


<210> 7490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 7490
taaagaaaaa aactgctgac                                                   20


<210> 7491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 7491
aggtaaatac atggacaaat                                                   20


<210> 7492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 7492
aagttaaatg tcaaaataat                                                   20


<210> 7493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 7493
aaaattacaa aaatgtgttt                                                   20


<210> 7494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 7494
aggaaaatcc acgtaaaaat                                                   20


<210> 7495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7495
taaaaataca gaaataaaaa                                                   20


<210> 7496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7496
cacaaaagaa gacagttaag                                                   20


<210> 7497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 7497
gacagttaag agagaaaaag                                                   20


<210> 7498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7498
agagagaaaa agacagaaaa                                                   20


<210> 7499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 7499
cagaaaaaaa gaattacaaa                                                   20


<210> 7500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7500
ccagatactc gtttcagatt                                                   20


<210> 7501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 7501
tgataaaaaa gatacatttt                                                   20


<210> 7502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 7502
accaaatgga tcacaaacac                                                   20


<210> 7503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 7503
taccatcttt tcaagtgcgc                                                   20


<210> 7504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7504
tcttgaaaaa gcaatgggtc                                                   20


<210> 7505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7505
gatacatgtc tacattataa                                                   20


<210> 7506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 7506
tagatttaca tgtctaggaa                                                   20


<210> 7507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 7507
tagagctaag taagtgaaat                                                   20


<210> 7508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7508
aaatagagaa taaaaaagca                                                   20


<210> 7509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 7509
atagaaaaag tcaacaaaac                                                   20


<210> 7510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7510
aaatccttag caagcataac                                                   20


<210> 7511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 7511
gaggactcaa atatgtaaaa                                                   20


<210> 7512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 7512
gtaaaaccag aaatgaaaga                                                   20


<210> 7513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 7513
caagactgaa tcatgaggaa                                                   20


<210> 7514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7514
taatgatagt aactcccaaa                                                   20


<210> 7515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7515
agtccaacca aacatttaaa                                                   20


<210> 7516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAT

<400> 7516
tcgaaagtca ttttatgggg                                                   20


<210> 7517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7517
aaagccagac aaagacactg                                                   20


<210> 7518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7518
cagacaaaga cactgtaaga                                                   20


<210> 7519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7519
cacatggatc agttctctcc                                                   20


<210> 7520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAT

<400> 7520
tcagttctct ccagagaaac                                                   20


<210> 7521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 7521
ccagagaaac ccagaatcca                                                   20


<210> 7522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 7522
aaactcatgc acaccagagg                                                   20


<210> 7523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 7523
aaatacccat atcaaaatgg                                                   20


<210> 7524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7524
gcacagtgcc ttacatttgg                                                   20


<210> 7525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 7525
tgcagctact tcccaagggt                                                   20


<210> 7526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 7526
ttaaggaaat gtatttattt                                                   20


<210> 7527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 7527
tggaaatcta catagcaaat                                                   20


<210> 7528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 7528
gacatgaaac tagaagtcaa                                                   20


<210> 7529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7529
tgaacaggca atgggtcaaa                                                   20


<210> 7530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 7530
agaagaaatt atacggaaaa                                                   20


<210> 7531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 7531
gataacaaat agtatggaat                                                   20


<210> 7532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7532
atgtagaaaa agaagccctg                                                   20


<210> 7533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7533
tagtaataaa tgcctacatt                                                   20


<210> 7534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 7534
ctaatattac atcttagaga                                                   20


<210> 7535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 7535
tagagattag aaaaagaaga                                                   20


<210> 7536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7536
atccccaaac tttgcagaag                                                   20


<210> 7537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7537
agaaaataac aaagataatg                                                   20


<210> 7538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 7538
tagaaggaat gaactaatct                                                   20


<210> 7539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 7539
gcaacctacc aagactaaat                                                   20


<210> 7540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7540
tgaacaaacc aatactggat                                                   20


<210> 7541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 7541
aaaaccctaa gagtatgcta                                                   20


<210> 7542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7542
cctaagagta tgctaccaga                                                   20


<210> 7543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 7543
cacttctttt tgacatagta                                                   20


<210> 7544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7544
ccatagcaat taggcaggaa                                                   20


<210> 7545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7545
agaaataaaa tacatccatg                                                   20


<210> 7546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 7546
aatacatcca tgtaagaaag                                                   20


<210> 7547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 7547
taatgacatg atctttatat                                                   20


<210> 7548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7548
ttgcagtttg caaaatcaac                                                   20


<210> 7549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7549
ttaacaatga ggtatccaac                                                   20


<210> 7550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7550
gaggtatcca acaaagaaat                                                   20


<210> 7551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 7551
tatttcatgt tcatgtgttg                                                   20


<210> 7552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 7552
aaattctaat gtcagttttc                                                   20


<210> 7553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 7553
aatggaaaag gataaaaagc                                                   20


<210> 7554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7554
ttgattttca gcaaaggtgc                                                   20


<210> 7555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7555
aactgaatat tccttatgca                                                   20


<210> 7556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7556
acaagtaaaa gacttaaata                                                   20


<210> 7557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7557
atgaaactat aaagctacta                                                   20


<210> 7558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7558
agctactaga agaaaacata                                                   20


<210> 7559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 7559
aagctcaagc aactcaacac                                                   20


<210> 7560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 7560
agaaaatcaa taaaccaatt                                                   20


<210> 7561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 7561
atgctcaaca tctctaatca                                                   20


<210> 7562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAT

<400> 7562
gaaatattac ctcacacctc                                                   20


<210> 7563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 7563
acaagtgttg atgaggatgt                                                   20


<210> 7564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 7564
tgtaaattag tacagctgtt                                                   20


<210> 7565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7565
ccatcaacag gtgaatgaat                                                   20


<210> 7566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 7566
ctaagcaaaa ttagccaggt                                                   20


<210> 7567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 7567
aaaagtgaga agtcaacatt                                                   20


<210> 7568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 7568
ggactggggg aagacgatgt                                                   20


<210> 7569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7569
taaagagctt ctgcacagca                                                   20


<210> 7570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 7570
acagagtaag cagacagtct                                                   20


<210> 7571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 7571
agcagacagt ctacagaatg                                                   20


<210> 7572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAT

<400> 7572
atctgacaaa ggtctaatat                                                   20


<210> 7573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 7573
aaggaactta aatgagttta                                                   20


<210> 7574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7574
gctcaatgtc actgaccatt                                                   20


<210> 7575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 7575
gagataccat ctcacaccag                                                   20


<210> 7576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 7576
acagatgctg gcgagggtgt                                                   20


<210> 7577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7577
tggcgagggt gtggagaaaa                                                   20


<210> 7578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 7578
aattcctcaa agacctaaag                                                   20


<210> 7579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 7579
ctattcacaa tggcaaagac                                                   20


<210> 7580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 7580
attagtaaac taaggcagga                                                   20


<210> 7581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7581
tgtatatttc aaaattgcta                                                   20


<210> 7582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 7582
aaaaatgaac aaatatttaa                                                   20


<210> 7583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7583
tttcatggta aaaactaaaa                                                   20


<210> 7584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 7584
gcaatttaat tgcaattgtg                                                   20


<210> 7585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 7585
tttaagaggt gtttaagtta                                                   20


<210> 7586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7586
cagcactaga agtcctagcc                                                   20


<210> 7587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 7587
tcctagccag agaaattagg                                                   20


<210> 7588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7588
gtaaaagaca tcccaatctg                                                   20


<210> 7589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7589
actaacaata aacaatctga                                                   20


<210> 7590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7590
aatctgaaga gaaaattagg                                                   20


<210> 7591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7591
tcccatttat gataacatca                                                   20


<210> 7592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7592
ctgaatagcc aaagcaatct                                                   20


<210> 7593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 7593
taagaaaaaa gaacaaaatg                                                   20


<210> 7594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 7594
aatgaaacag gatagagagc                                                   20


<210> 7595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 7595
ctcatattca acaggggtgc                                                   20


<210> 7596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7596
aggggtgcca agaatacaca                                                   20


<210> 7597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7597
tgaaaactgt aaaacttgta                                                   20


<210> 7598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 7598
agagggtgaa aaagcaacct                                                   20


<210> 7599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 7599
aaaaagcaac ctatagaatg                                                   20


<210> 7600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 7600
atgctcagta tcactaatca                                                   20


<210> 7601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 7601
ctacttggga agctgaggca                                                   20


<210> 7602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 7602
ctacacggga ggctgaggca                                                   20


<210> 7603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 7603
ataggtgttg gcaaggatat                                                   20


<210> 7604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7604
tgtaaaatga tgtagctgcc                                                   20


<210> 7605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7605
gtctattgat gaatgatggg                                                   20


<210> 7606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 7606
aatttatgct gagtgaagta                                                   20


<210> 7607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 7607
caaactcatg gaaacagaga                                                   20


<210> 7608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 7608
tgccagggca tgaaaggatg                                                   20


<210> 7609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 7609
gcatgaaagg atgggagaat                                                   20


<210> 7610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7610
taattaaaat taggaaaggc                                                   20


<210> 7611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7611
gttttttcag ggaagagtgg                                                   20


<210> 7612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 7612
ggaaagaaat tctaaatcat                                                   20


<210> 7613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 7613
tctaaatcat tcagaaaagg                                                   20


<210> 7614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 7614
gattgcaaga tgaaatactg                                                   20


<210> 7615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 7615
atcctatttt acttcctgca                                                   20


<210> 7616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 7616
ttcctgcagt agaaatgttg                                                   20


<210> 7617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 7617
tgtatatata atgcttaagt                                                   20


<210> 7618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 7618
agagtatctc agttagttga                                                   20


<210> 7619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAT

<400> 7619
cagttagttg acaagaaact                                                   20


<210> 7620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 7620
ttttttgtaa agctcagtct                                                   20


<210> 7621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 7621
aagtcctaac ccttagcact                                                   20


<210> 7622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 7622
ctggcatcct tactagtaga                                                   20


<210> 7623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 7623
ggagttctgt tgccataaac                                                   20


<210> 7624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 7624
ttctaacctc caaaagtgtg                                                   20


<210> 7625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7625
ttatcctgtt ctcgtaggtc                                                   20


<210> 7626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 7626
tataggaaac attggaaaaa                                                   20


<210> 7627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 7627
agttagccag aacctattat                                                   20


<210> 7628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 7628
ccaatgaaca agttcaaagt                                                   20


<210> 7629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAT

<400> 7629
gcttggatga tatggtacag                                                   20


<210> 7630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 7630
gataatcaat acttacatta                                                   20


<210> 7631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 7631
catcccttaa aagttgcctt                                                   20


<210> 7632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 7632
tgcctttaag aataacatta                                                   20


<210> 7633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7633
ttataattaa tatactattt                                                   20


<210> 7634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAT

<400> 7634
cccatgatgc tgaatatcag                                                   20


<210> 7635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7635
tcacaacgac ctagtattca                                                   20


<210> 7636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7636
aacgacctag tattcaaaag                                                   20


<210> 7637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7637
gatgttaaat aggcaacatg                                                   20


<210> 7638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 7638
gccatgcaga cataaataaa                                                   20


<210> 7639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7639
atctgtacac tctggaaaaa                                                   20


<210> 7640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7640
agcattaaag attcccccat                                                   20


<210> 7641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 7641
gacattctcc acaaaaggat                                                   20


<210> 7642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7642
ttctcaagat gctttaaaat                                                   20


<210> 7643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 7643
agattaggag gaataggaat                                                   20


<210> 7644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 7644
atgatggaat catgggtctc                                                   20


<210> 7645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 7645
ttgtaatttt caacttgtag                                                   20


<210> 7646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 7646
agtaggtctg gggtgagatc                                                   20


<210> 7647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 7647
ttttaggtgt ctgaacagag                                                   20


<210> 7648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7648
atagcaggta taaatctgga                                                   20


<210> 7649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 7649
catgaggata tggactaatt                                                   20


<210> 7650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 7650
cagcctatgt atttatgtaa                                                   20


<210> 7651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7651
tgtttgccac taaagtaacc                                                   20


<210> 7652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7652
aagaaggtta accaaaataa                                                   20


<210> 7653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7653
aagttgttta ttctatttga                                                   20


<210> 7654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 7654
ctaccaaata gtttttcatg                                                   20


<210> 7655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 7655
aaatcacaat tgtactgaag                                                   20


<210> 7656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7656
attaccataa ccagtatcca                                                   20


<210> 7657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7657
gttcttatcg taaattatct                                                   20


<210> 7658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7658
gtgtagcagg agacgatgtc                                                   20


<210> 7659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 7659
agagattcaa tttttcgagg                                                   20


<210> 7660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 7660
tatatttatc tatttcaggc                                                   20


<210> 7661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAT

<400> 7661
ttcctaaagc tacgtattta                                                   20


<210> 7662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 7662
tatgtatgct ccctctttaa                                                   20


<210> 7663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 7663
ctctctggtg tgcccaccag                                                   20


<210> 7664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7664
cttcccagct tccagaactt                                                   20


<210> 7665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 7665
actatggtat agtttgtaac                                                   20


<210> 7666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAA

<400> 7666
ttcaaataac ccagaagcct                                                   20


<210> 7667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 7667
ttctgaaatc tgaatataca                                                   20


<210> 7668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAT

<400> 7668
agtatgtctt ggggttgggg                                                   20


<210> 7669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 7669
tagataagtt tctatacttt                                                   20


<210> 7670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 7670
aaaatttgca tctctgtcag                                                   20


<210> 7671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 7671
gaacaggagg ttatactcac                                                   20


<210> 7672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7672
cccgtcatat ttacagttta                                                   20


<210> 7673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7673
catatttaca gtttaagaga                                                   20


<210> 7674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 7674
aatgattaat tgaaaaatag                                                   20


<210> 7675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 7675
aatcattact atatccgaag                                                   20


<210> 7676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7676
attttttcac attacatatt                                                   20


<210> 7677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7677
catttaatat gttgtgtgat                                                   20


<210> 7678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 7678
atgaagcttt gaataacagt                                                   20


<210> 7679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 7679
gttaggtttc tgaaaatcta                                                   20


<210> 7680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 7680
agataaagaa catatcattc                                                   20


<210> 7681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7681
attgaggtta taaaataatg                                                   20


<210> 7682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7682
gttaaaataa tatgtaaact                                                   20


<210> 7683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 7683
ttgtatttgt ataatgattt                                                   20


<210> 7684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 7684
aaattttgtt ttattcttaa                                                   20


<210> 7685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAA

<400> 7685
taaaaaatca catctccttt                                                   20


<210> 7686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 7686
attataaatg ttacaatgtc                                                   20


<210> 7687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7687
tggctgtgtt aatatttcta                                                   20


<210> 7688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 7688
ggttttttca caacacacag                                                   20


<210> 7689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAT

<400> 7689
tatccatttt agaagcattt                                                   20


<210> 7690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7690
ctgctggtct tcagaggtca                                                   20


<210> 7691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7691
agaggtcaag agaaagtgca                                                   20


<210> 7692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 7692
gcggtgcttc ctatgctttc                                                   20


<210> 7693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7693
tcagccacat gtcccttgac                                                   20


<210> 7694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7694
aaactgttgg tatcaatatt                                                   20


<210> 7695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAA

<400> 7695
aagaaaagag acaagttggg                                                   20


<210> 7696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 7696
gactggtccc agagcaggaa                                                   20


<210> 7697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 7697
tggatgtagg agcaaggagg                                                   20


<210> 7698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 7698
agggttgttt gaaaattaaa                                                   20


<210> 7699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 7699
atttatttaa aatacacttt                                                   20


<210> 7700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 7700
caggttgttg gggagtgtgc                                                   20


<210> 7701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 7701
cctgggtaaa gggggaacca                                                   20


<210> 7702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7702
tcagcaggaa aaatgacaat                                                   20


<210> 7703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 7703
ggaagctgct tgtatgtgta                                                   20


<210> 7704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 7704
tgcttgtatg tgtacaagaa                                                   20


<210> 7705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 7705
cctcagcctg ccttgcctaa                                                   20


<210> 7706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 7706
ctccattgct ctgagctcct                                                   20


<210> 7707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 7707
cagggtacaa aacattactc                                                   20


<210> 7708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7708
tttatctttt agctcatttt                                                   20


<210> 7709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 7709
aacctccata cacaacctga                                                   20


<210> 7710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 7710
tgcatgttaa atcttgatat                                                   20


<210> 7711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 7711
tacacctttc taaacaatat                                                   20


<210> 7712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7712
aactcctgaa attaagttca                                                   20


<210> 7713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 7713
ttttggttag gtagataaaa                                                   20


<210> 7714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7714
gggttcattt tgatagcatg                                                   20


<210> 7715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 7715
atctcacctg gcttatttct                                                   20


<210> 7716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7716
ggcagcaaaa attgttatgc                                                   20


<210> 7717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 7717
gcatagaaat ttaaaccagt                                                   20


<210> 7718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAT

<400> 7718
agtttagaat tgtgatgcaa                                                   20


<210> 7719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 7719
ggcaagggtg agaggtgagc                                                   20


<210> 7720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7720
gaatagagag gagtaggggt                                                   20


<210> 7721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 7721
gggtgaagaa agtttcatac                                                   20


<210> 7722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7722
ttgattggat atcaaatgta                                                   20


<210> 7723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 7723
ctgaaacggg aaaaacctgt                                                   20


<210> 7724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7724
acgggaaaaa cctgtctaga                                                   20


<210> 7725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAA

<400> 7725
aaaaagagta tttagggtga                                                   20


<210> 7726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 7726
tgaaacaaca atattaaggg                                                   20


<210> 7727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 7727
caattcttgt tgttaaactg                                                   20


<210> 7728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 7728
aaatatttga ctatataaac                                                   20


<210> 7729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 7729
gagcttcttg attttctaga                                                   20


<210> 7730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 7730
agttcaaaaa aagcattctt                                                   20


<210> 7731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 7731
tttgagaaac aatttgatat                                                   20


<210> 7732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 7732
acatcactag gacaggtaga                                                   20


<210> 7733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7733
gaccaagagg gtgcagtaaa                                                   20


<210> 7734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 7734
gagctatgaa cataagaggc                                                   20


<210> 7735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 7735
tgaacataag aggcccagaa                                                   20


<210> 7736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAT

<400> 7736
tttaaagttt attaaagcaa                                                   20


<210> 7737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7737
aaagcaacta gaattactct                                                   20


<210> 7738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 7738
gaaggcagga ggtgggaaag                                                   20


<210> 7739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAT

<400> 7739
tatgttctaa aacaacaaaa                                                   20


<210> 7740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 7740
ctcttgacaa gatgcacctg                                                   20


<210> 7741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7741
gcactttaat ttccagctct                                                   20


<210> 7742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7742
ttacataaac attggatgaa                                                   20


<210> 7743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 7743
tttaatatta acttagtgct                                                   20


<210> 7744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7744
ttaaaaacaa tgatcacata                                                   20


<210> 7745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7745
aaacaatgat cacatataag                                                   20


<210> 7746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7746
ctcaggggca aattattgga                                                   20


<210> 7747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 7747
aaaaacacta aaaatcctaa                                                   20


<210> 7748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 7748
taattgaatg taaacataac                                                   20


<210> 7749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7749
aaaaaaaaaa aaaggaaagg                                                   20


<210> 7750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7750
aaaaaaggaa aggaaagaaa                                                   20


<210> 7751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7751
ttgttaacat tatctttcca                                                   20


<210> 7752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7752
taacattatc tttccaaaag                                                   20


<210> 7753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 7753
tggttattgt gttactaaag                                                   20


<210> 7754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 7754
tggcttctcc taccaagtta                                                   20


<210> 7755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 7755
agctaatttt tgtattttta                                                   20


<210> 7756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7756
aacaaccttg cataagaggg                                                   20


<210> 7757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAA

<400> 7757
cacctctcac ctggatttat                                                   20


<210> 7758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 7758
ctggatttat gcagaaactc                                                   20


<210> 7759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7759
tcaattttct ttacatcacg                                                   20


<210> 7760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7760
aattatttgt ttactggaat                                                   20


<210> 7761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAT

<400> 7761
ccaacttctt tctagttatc                                                   20


<210> 7762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7762
atgatatttg gtgtgtattt                                                   20


<210> 7763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7763
tgcttaaccc atgaatgtta                                                   20


<210> 7764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 7764
gaatgttata agaaaccagt                                                   20


<210> 7765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 7765
acttctgtat aagattgtta                                                   20


<210> 7766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 7766
agattgttaa cagaatcctt                                                   20


<210> 7767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7767
ttaacagaat ccttgaagaa                                                   20


<210> 7768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7768
ctgacaaatt ccagaagtag                                                   20


<210> 7769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 7769
gtagtaagaa attcagcata                                                   20


<210> 7770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 7770
tgatgttaag agtcaatagc                                                   20


<210> 7771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 7771
gcatgaaaca cctcagagct                                                   20


<210> 7772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7772
aacacctcag agcttcagaa                                                   20


<210> 7773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 7773
actgaagatt gaacatgtgg                                                   20


<210> 7774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAA

<400> 7774
aatcattatt tacaggatgt                                                   20


<210> 7775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7775
gtgcagaaaa aatactcatt                                                   20


<210> 7776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 7776
gcctctgaaa ctaaggaaag                                                   20


<210> 7777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 7777
gagcttgacc ggtttaatct                                                   20


<210> 7778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 7778
atataacatt ttagtatata                                                   20


<210> 7779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 7779
aacagtatta tttataatgt                                                   20


<210> 7780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7780
caaactctga aacaaagatc                                                   20


<210> 7781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7781
acacatacac acacacacac                                                   20


<210> 7782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7782
gtttaattta aaataagata                                                   20


<210> 7783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 7783
actgaatatt ctataaaact                                                   20


<210> 7784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 7784
taggctttaa agtataaact                                                   20


<210> 7785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7785
caggcccttc atttctgaaa                                                   20


<210> 7786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7786
agcagtgaga ggaattgctg                                                   20


<210> 7787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7787
gtgagaggaa ttgctgatag                                                   20


<210> 7788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAT

<400> 7788
aaataaaatg attcttattt                                                   20


<210> 7789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 7789
tcaattgaat tcagcttggc                                                   20


<210> 7790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 7790
caatattatt gttcaatggg                                                   20


<210> 7791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 7791
gcttctttag cagatttcta                                                   20


<210> 7792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7792
ttctaagaga atacctttat                                                   20


<210> 7793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7793
tccatgtaat tttggaaatg                                                   20


<210> 7794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7794
gaaataaatg ctttagtatg                                                   20


<210> 7795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7795
ccccttgagg taatcgagag                                                   20


<210> 7796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 7796
ttttctacta tactgcttga                                                   20


<210> 7797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7797
tgataatcta acgctcaaaa                                                   20


<210> 7798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 7798
tcaacaaaaa ccttactcaa                                                   20


<210> 7799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAT

<400> 7799
tattctttaa ggagcagagc                                                   20


<210> 7800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7800
aaaatactca caaaagacag                                                   20


<210> 7801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7801
gaggagatgg gtataaaaga                                                   20


<210> 7802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 7802
ctccattatc tgttaataag                                                   20


<210> 7803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7803
aggatcaaag gatcctttga                                                   20


<210> 7804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 7804
gcctttattt ttttccttct                                                   20


<210> 7805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAA

<400> 7805
atgttacttc cactaattta                                                   20


<210> 7806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 7806
ctcttttttt aaaaaaaggg                                                   20


<210> 7807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7807
tttctttgtc tattgctagc                                                   20


<210> 7808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7808
gtcaaatctc agccaccacc                                                   20


<210> 7809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 7809
tcagccacca ccagagaaat                                                   20


<210> 7810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 7810
acggagacct cttctttttc                                                   20


<210> 7811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7811
aaatgataag atatgaatat                                                   20


<210> 7812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7812
agaactgcta cactgtttgc                                                   20


<210> 7813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 7813
atctataatt ttgaaacaaa                                                   20


<210> 7814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7814
ttctaatatt gaaaatataa                                                   20


<210> 7815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 7815
acagcttggt aaaaaagtaa                                                   20


<210> 7816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 7816
ctatgcatgt atatatattt                                                   20


<210> 7817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7817
tccttattta ggctctagtt                                                   20


<210> 7818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 7818
tggaataaaa tagttttcta                                                   20


<210> 7819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7819
aaatccccac caaatttgaa                                                   20


<210> 7820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7820
acaaacatct caacaatgac                                                   20


<210> 7821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 7821
agtatgtatt ttaatacatt                                                   20


<210> 7822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 7822
tgatctgatt atgtatataa                                                   20


<210> 7823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7823
ccaactttct agatgtgtac                                                   20


<210> 7824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAT

<400> 7824
gcttatccat aaatacataa                                                   20


<210> 7825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAT

<400> 7825
cagaattatt aaatacaaag                                                   20


<210> 7826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 7826
tctgagattt tatatttatg                                                   20


<210> 7827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 7827
gttacatcaa gaagtcatca                                                   20


<210> 7828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAA

<400> 7828
actttcttgc agtgggtcag                                                   20


<210> 7829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 7829
agaaggttag gtactgaatt                                                   20


<210> 7830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 7830
ttaaagtcat atacctgtaa                                                   20


<210> 7831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7831
ttccaaattt atcaaaatat                                                   20


<210> 7832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 7832
aaaaaatcta tgcataaaat                                                   20


<210> 7833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7833
ctttgattaa aaatctaaag                                                   20


<210> 7834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7834
tttcatgagt gtaatttagg                                                   20


<210> 7835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7835
ataattctgg gcagagagtc                                                   20


<210> 7836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7836
ttctctacta tgcacaaata                                                   20


<210> 7837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7837
taacataata tttatgtaat                                                   20


<210> 7838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 7838
taagaaataa gattatacag                                                   20


<210> 7839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7839
tagtaactgc atctcttaaa                                                   20


<210> 7840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 7840
ccttccaagg tatcttacca                                                   20


<210> 7841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7841
taatcatagg cattaatata                                                   20


<210> 7842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 7842
ggatgtttta aaatatgaaa                                                   20


<210> 7843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 7843
cagttaaaca gagtcctgac                                                   20


<210> 7844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 7844
caaagagagc aaagtgatgt                                                   20


<210> 7845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 7845
cagcaaggtt ttcacctaga                                                   20


<210> 7846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 7846
aggaaagggt tatgtagtct                                                   20


<210> 7847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7847
aagggttatg tagtcttgag                                                   20


<210> 7848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7848
gaagggaata agatagtttt                                                   20


<210> 7849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 7849
ggtggattag aagcacaata                                                   20


<210> 7850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 7850
aaatgtacaa taccattaca                                                   20


<210> 7851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAA

<400> 7851
tacaccatta cagaggtata                                                   20


<210> 7852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 7852
ccaaatcttt tcttaatctt                                                   20


<210> 7853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7853
catccaatga atggtgtgga                                                   20


<210> 7854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7854
tataactggg gtccttataa                                                   20


<210> 7855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 7855
gaaaagaccg agacacacag                                                   20


<210> 7856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 7856
attgccaaca acctccaaag                                                   20


<210> 7857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7857
ggatacttac tagagccttt                                                   20


<210> 7858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7858
tctagcctcc agaactggca                                                   20


<210> 7859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7859
ctaatttgtt acaacagccg                                                   20


<210> 7860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 7860
tcagttcagt gcctgcattc                                                   20


<210> 7861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 7861
aaattctcca taaactctgt                                                   20


<210> 7862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7862
tatacccata gcccctgaat                                                   20


<210> 7863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 7863
tgaataaaga aaataatatc                                                   20


<210> 7864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 7864
ggcatttctt tgtcttcttt                                                   20


<210> 7865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7865
cttttttttt ttttttctgt                                                   20


<210> 7866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7866
agattatttg ttgttaacat                                                   20


<210> 7867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 7867
atcagatcat ataaaaacaa                                                   20


<210> 7868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7868
tatcttgttc cagatcttgg                                                   20


<210> 7869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7869
tttcattctg ttgatataat                                                   20


<210> 7870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 7870
attggggtaa tattggcctt                                                   20


<210> 7871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 7871
ggccttgtag aatgaattta                                                   20


<210> 7872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 7872
atttttttgg aataatttaa                                                   20


<210> 7873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 7873
agttcttctt taaatgtttg                                                   20


<210> 7874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 7874
agcatttgtc taattattta                                                   20


<210> 7875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 7875
caagtgggag atgaagatta                                                   20


<210> 7876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 7876
aacaaaacaa aacaaaaatg                                                   20


<210> 7877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7877
ttttaatctg aagaggctgg                                                   20


<210> 7878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAA

<400> 7878
tcttaagtaa taataatgat                                                   20


<210> 7879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 7879
accatggaaa tgtaatagag                                                   20


<210> 7880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 7880
tagatataac cattatgtaa                                                   20


<210> 7881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 7881
agaaaaaaat tagtgaaaat                                                   20


<210> 7882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 7882
attagtgaaa atcaagaata                                                   20


<210> 7883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 7883
acaaagagag gacaagagag                                                   20


<210> 7884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 7884
taatgagtct gctttttcag                                                   20


<210> 7885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 7885
aatgttgcaa ctcaacatac                                                   20


<210> 7886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 7886
gcaactcaac atactaagaa                                                   20


<210> 7887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7887
tcagccattg actttaaatg                                                   20


<210> 7888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7888
atgaaagaaa aatgaacagg                                                   20


<210> 7889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7889
aaataattcc tcataaatgt                                                   20


<210> 7890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAT

<400> 7890
ctcctgaagt gctttaacac                                                   20


<210> 7891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 7891
taaatgggtg acagagttag                                                   20


<210> 7892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7892
gaaaaaatgt ccttggctac                                                   20


<210> 7893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7893
aatactttct aacatgagct                                                   20


<210> 7894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 7894
tcaatacata ccttgactca                                                   20


<210> 7895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 7895
aagggactac atccatttgg                                                   20


<210> 7896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 7896
agcaactggg gaaaaagttt                                                   20


<210> 7897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7897
aatcaattat taagaactag                                                   20


<210> 7898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7898
gttaagaaga acttatgaca                                                   20


<210> 7899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 7899
tcatttcagc aagtgtatgg                                                   20


<210> 7900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 7900
tggctttttg gaaaatgctt                                                   20


<210> 7901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 7901
aaatgagctc aataataagg                                                   20


<210> 7902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7902
tcagggtggg gagagggggt                                                   20


<210> 7903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 7903
agagggtcag ccatacccag                                                   20


<210> 7904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 7904
agaattacca tggggagcag                                                   20


<210> 7905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 7905
tcattactct ttattacctg                                                   20


<210> 7906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAT

<400> 7906
tattctgtcc aagaagcgtg                                                   20


<210> 7907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 7907
cttaatgtga cttttaaagc                                                   20


<210> 7908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 7908
gtctcaataa gtctgattta                                                   20


<210> 7909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7909
tattatcatg ttaaacaaga                                                   20


<210> 7910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7910
aactggcaat aaaatgatca                                                   20


<210> 7911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7911
aatgatcaaa agaataaatt                                                   20


<210> 7912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 7912
cttctgtata ctttctttgc                                                   20


<210> 7913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7913
tttgccaaga attaataatt                                                   20


<210> 7914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7914
tttatgtcaa aattttgtaa                                                   20


<210> 7915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 7915
ctactcagga ggctgaggca                                                   20


<210> 7916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7916
tataaataca aaacagagaa                                                   20


<210> 7917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 7917
aaacagagaa gaagaaacaa                                                   20


<210> 7918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 7918
cttgagggtg atcaacaatt                                                   20


<210> 7919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAT

<400> 7919
attttttgtg cagtaaaaat                                                   20


<210> 7920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 7920
acaagtcaac gtggcagatt                                                   20


<210> 7921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7921
ttttcactaa tcagtataag                                                   20


<210> 7922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 7922
aataaaaaaa aagtacaagc                                                   20


<210> 7923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7923
atgccatcac tttcaaaatt                                                   20


<210> 7924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7924
tttcaaaatt agagaaaaag                                                   20


<210> 7925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7925
catcacaaaa taatttccac                                                   20


<210> 7926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7926
aaaattacaa cacatattat                                                   20


<210> 7927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7927
acttttagtt caggattgct                                                   20


<210> 7928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 7928
taatttgtga tatttttctt                                                   20


<210> 7929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7929
taaattattg tactatatta                                                   20


<210> 7930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 7930
atattagcgt gtacttcaaa                                                   20


<210> 7931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7931
tttaaaaata atgcaaaacc                                                   20


<210> 7932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 7932
caaagaaata cccctttatt                                                   20


<210> 7933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 7933
tgacaatcct tccacatctg                                                   20


<210> 7934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 7934
gattccagta aagacctaag                                                   20


<210> 7935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 7935
ataatgtttt tctgttaata                                                   20


<210> 7936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 7936
catcattttt agacagcatt                                                   20


<210> 7937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 7937
ttgacacagt cactattttc                                                   20


<210> 7938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7938
gttgttctgg aagaagataa                                                   20


<210> 7939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7939
tttaaagatt tatcagcaga                                                   20


<210> 7940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 7940
atccggatct ccaccaacaa                                                   20


<210> 7941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 7941
caaagataaa tagaagggaa                                                   20


<210> 7942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7942
gaatatttgt agacaattta                                                   20


<210> 7943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 7943
atttagaaga aaagacagac                                                   20


<210> 7944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAA

<400> 7944
actatatgcc aggctaataa                                                   20


<210> 7945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 7945
cagaaagcat ttaatcctcc                                                   20


<210> 7946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAT

<400> 7946
gggcatatca ctcatataat                                                   20


<210> 7947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 7947
atatgtgagg tgtgtactta                                                   20


<210> 7948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 7948
gcaatgtaat taggaaggtg                                                   20


<210> 7949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 7949
aaaatgttaa gtgttgctcc                                                   20


<210> 7950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAA

<400> 7950
tgctcccaag aaatatgctg                                                   20


<210> 7951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7951
tcccaagatg gtaacctttt                                                   20


<210> 7952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 7952
aattatttta aaagacataa                                                   20


<210> 7953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7953
gacaatgatg acaactaaaa                                                   20


<210> 7954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 7954
tatggagagc aattccagat                                                   20


<210> 7955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 7955
tctggactct tcaagttctg                                                   20


<210> 7956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7956
cacatatgtg ggcatctttc                                                   20


<210> 7957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7957
gagaactatg tttccttaac                                                   20


<210> 7958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 7958
ataagatgag actattctgt                                                   20


<210> 7959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 7959
acaatcctag aaccaagcaa                                                   20


<210> 7960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 7960
atttgtaaga ttatatagtg                                                   20


<210> 7961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 7961
tatggtctct gaattcttcc                                                   20


<210> 7962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 7962
agatttatgt taattttatt                                                   20


<210> 7963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 7963
aatcaattaa tgtcttaaga                                                   20


<210> 7964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 7964
agtgctgtgt atctaaaggg                                                   20


<210> 7965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 7965
aaaggaacaa ttagtgaaat                                                   20


<210> 7966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 7966
gaggtgacct ctcttcagct                                                   20


<210> 7967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 7967
aacaagtgta tttatttttg                                                   20


<210> 7968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 7968
ctatgttggt tccatgcagg                                                   20


<210> 7969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 7969
ctgtgctata gtctgtcaaa                                                   20


<210> 7970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7970
tggtgaaaaa actcttaaat                                                   20


<210> 7971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 7971
tgcaagcaaa gtttgattcc                                                   20


<210> 7972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 7972
tatcctggaa actccaggaa                                                   20


<210> 7973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7973
caagtaatcc aaatttcttc                                                   20


<210> 7974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 7974
gagttagatg cctacaacac                                                   20


<210> 7975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 7975
tgaatcaaag gtgtgttcct                                                   20


<210> 7976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAA

<400> 7976
ttgttctgct gcttcgcctt                                                   20


<210> 7977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAA

<400> 7977
acgaatgctg agtggtgact                                                   20


<210> 7978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 7978
ggtggctctg tactgactta                                                   20


<210> 7979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 7979
aaaacgaagc aattcagtga                                                   20


<210> 7980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 7980
cttaagggat gaaacaattt                                                   20


<210> 7981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 7981
tttttttact gtgtatatca                                                   20


<210> 7982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 7982
tttttaacta gatttttagt                                                   20


<210> 7983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAT

<400> 7983
ggttcatctt ggggatttgt                                                   20


<210> 7984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7984
agatgaaggt ttcagtgaaa                                                   20


<210> 7985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 7985
gaaagagaac ttccacataa                                                   20


<210> 7986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7986
atactattac ctatactgtt                                                   20


<210> 7987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 7987
cctatactgt ttaagaaaga                                                   20


<210> 7988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 7988
cttctgaaaa ttagtttatt                                                   20


<210> 7989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 7989
tcgttttctt tacacaatga                                                   20


<210> 7990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 7990
aaataaagct ctattgtatt                                                   20


<210> 7991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 7991
caattaactc catatcatca                                                   20


<210> 7992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 7992
attattaaag cataatattg                                                   20


<210> 7993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 7993
aataaagata taaatgaaaa                                                   20


<210> 7994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 7994
aaaaaaagtc atcttacctc                                                   20


<210> 7995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 7995
ctgcactgaa tatttgtgca                                                   20


<210> 7996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 7996
ccttctcaaa catttacact                                                   20


<210> 7997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CGAGAAT

<400> 7997
aggattaagg aggaaacttt                                                   20


<210> 7998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAT

<400> 7998
agtatcaatt ctagctcagc                                                   20


<210> 7999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 7999
aattggttcc tttttccaca                                                   20


<210> 8000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8000
tttatacaca aaaattcatt                                                   20


<210> 8001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 8001
gtttgcattt ctacctctag                                                   20


<210> 8002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 8002
tcatgttatc aaaaatataa                                                   20


<210> 8003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 8003
attaaacaca ttttcagtac                                                   20


<210> 8004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 8004
cgctttcttt gctttttaaa                                                   20


<210> 8005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 8005
ctgttcctgt tttagtttgc                                                   20


<210> 8006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 8006
tgtgtgcatg tgtctttacc                                                   20


<210> 8007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 8007
tgtgtgcatg tgtctttgta                                                   20


<210> 8008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAT

<400> 8008
actatttctt catagcctca                                                   20


<210> 8009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 8009
ctggccaggg caatcagaca                                                   20


<210> 8010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8010
ccagggcaat cagacaagag                                                   20


<210> 8011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 8011
caaatgacat gattctatat                                                   20


<210> 8012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 8012
cccatttgca attgctataa                                                   20


<210> 8013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 8013
cattccatac tcatggatag                                                   20


<210> 8014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 8014
aaattaccat tgacatcttc                                                   20


<210> 8015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 8015
ccattgacat cttcacagaa                                                   20


<210> 8016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 8016
cagacatata ggccaatgga                                                   20


<210> 8017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 8017
aatggaatag aatagagacc                                                   20


<210> 8018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAA

<400> 8018
gggaagctgg ctagccatat                                                   20


<210> 8019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 8019
cccaaaccat gaaaacccta                                                   20


<210> 8020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8020
taaagagctt ctgcacagca                                                   20


<210> 8021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 8021
tcagagtgaa caggcaaact                                                   20


<210> 8022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 8022
aacaggcaaa ctatagaatg                                                   20


<210> 8023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 8023
atctgacaaa ggtctaatat                                                   20


<210> 8024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8024
taaatataaa ataggccaaa                                                   20


<210> 8025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 8025
aaacagatct gcagctattc                                                   20


<210> 8026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 8026
gaatcattgt tatgtgtact                                                   20


<210> 8027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 8027
agagatcaat gatataaatg                                                   20


<210> 8028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 8028
ttgggagcaa ttgatttggg                                                   20


<210> 8029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 8029
gatttgggag agaaaaactt                                                   20


<210> 8030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 8030
gtccatgtgc aggagcagct                                                   20


<210> 8031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 8031
gatctagaga ttaaatatgc                                                   20


<210> 8032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 8032
ttaaatatgc ccagaaaaga                                                   20


<210> 8033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CGAGAAA

<400> 8033
ctctggacac tgactacaca                                                   20


<210> 8034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 8034
ggacaatatt gaataaggat                                                   20


<210> 8035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 8035
taggataata acatctacct                                                   20


<210> 8036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 8036
acttagctta catcctgcac                                                   20


<210> 8037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 8037
cctatgagtc acatttaatt                                                   20


<210> 8038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 8038
agaatgagtg gaacttggga                                                   20


<210> 8039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8039
tgagtggaac ttgggagtag                                                   20


<210> 8040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 8040
actttgtgac tcttcgtttt                                                   20


<210> 8041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 8041
aagactggat ttgctgtggg                                                   20


<210> 8042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 8042
tgaaatatat aaaaagcaat                                                   20


<210> 8043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8043
tctttcagcc tttagactaa                                                   20


<210> 8044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 8044
aataaaaata ttctgttgaa                                                   20


<210> 8045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8045
cagatagtga taaatgatct                                                   20


<210> 8046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 8046
gagatatttg ggctggggga                                                   20


<210> 8047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 8047
catgtcggaa tttgcatatc                                                   20


<210> 8048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 8048
ttaatgactg tgatacattc                                                   20


<210> 8049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 8049
tggaaagtgt gtatctaaag                                                   20


<210> 8050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 8050
agacttttgg agtaatcatg                                                   20


<210> 8051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 8051
ctgcatctgt aaaatacgta                                                   20


<210> 8052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 8052
tttaataagg atggattact                                                   20


<210> 8053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 8053
ctactgtatt taacacagta                                                   20


<210> 8054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 8054
aggtagctca ctctaggttt                                                   20


<210> 8055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8055
aatgggaaaa aattgaatgc                                                   20


<210> 8056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 8056
gtgggatgat tctgaaagat                                                   20


<210> 8057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 8057
ctacttggca ggctgaggca                                                   20


<210> 8058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8058
gaaatatcat ttagcaataa                                                   20


<210> 8059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 8059
gagtgggtaa atccctaggg                                                   20


<210> 8060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 8060
ttagtggttg ccaggggctg                                                   20


<210> 8061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 8061
aaaattgata taacaaaaat                                                   20


<210> 8062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 8062
ttcaagatta atgtagcaaa                                                   20


<210> 8063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 8063
aatggtaatt ctgcccttgc                                                   20


<210> 8064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 8064
aagggcaaat aatgcaactc                                                   20


<210> 8065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 8065
tctggcaaat gtagttctca                                                   20


<210> 8066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 8066
tctctattaa atgtcaaata                                                   20


<210> 8067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 8067
atattagaaa aacaggagga                                                   20


<210> 8068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 8068
aaaatacttt gctataggca                                                   20


<210> 8069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 8069
ccaaatggct gaatgttggt                                                   20


<210> 8070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 8070
gcattctcat caaatcatct                                                   20


<210> 8071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 8071
ctttatagcc aaatttcttg                                                   20


<210> 8072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 8072
accacttacc caaattttct                                                   20


<210> 8073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 8073
cacccatcca gttattgcag                                                   20


<210> 8074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 8074
ttcactaaaa ctacatttca                                                   20


<210> 8075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 8075
actacatttc agaagaaaat                                                   20


<210> 8076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 8076
aaaaaataca tgaagcaatt                                                   20


<210> 8077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 8077
taaaggctgt ctgtgtacat                                                   20


<210> 8078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 8078
atttttcttt taacaaaggt                                                   20


<210> 8079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 8079
aaaccattca cagtataaac                                                   20


<210> 8080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 8080
ctcagaaata ggagcaagac                                                   20


<210> 8081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 8081
aataaaagga cagatcccag                                                   20


<210> 8082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 8082
taattttaca gcatataaat                                                   20


<210> 8083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 8083
tcaaatcatg tttgtaacaa                                                   20


<210> 8084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 8084
attttattta tcacagtgag                                                   20


<210> 8085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 8085
aaaggacaca tttggtaaaa                                                   20


<210> 8086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 8086
tattactttt tattatctaa                                                   20


<210> 8087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 8087
agatacattc caggtgtcag                                                   20


<210> 8088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 8088
cattcaattc atgctttatg                                                   20


<210> 8089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 8089
gatgatctca tgtggtacct                                                   20


<210> 8090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 8090
aaggctacat ttatttctct                                                   20


<210> 8091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 8091
aaataattct tttttatgat                                                   20


<210> 8092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 8092
acacagtcag gatcatgaca                                                   20


<210> 8093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 8093
tgtcttcagg cctgaaaatg                                                   20


<210> 8094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 8094
aacaaaaaac acaagctttc                                                   20


<210> 8095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 8095
aaaaatagga acatattctc                                                   20


<210> 8096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8096
accttgtaat aattttcaat                                                   20


<210> 8097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 8097
tcaataaaga aatggtttgc                                                   20


<210> 8098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 8098
gataatgatt gtggaaaaca                                                   20


<210> 8099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8099
aaatttaatt aaaattgcat                                                   20


<210> 8100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 8100
attacttctt acctgggatt                                                   20


<210> 8101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 8101
acaaattctg ttaaatacct                                                   20


<210> 8102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 8102
taaatacctg tagaattaaa                                                   20


<210> 8103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 8103
tagaattaaa tcagaattat                                                   20


<210> 8104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 8104
ttcaaagtca ttaacggaaa                                                   20


<210> 8105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 8105
cagccagttc cacgggtcac                                                   20


<210> 8106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 8106
cattgggata ctagatgtga                                                   20


<210> 8107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 8107
ttaaactaca ataggtctat                                                   20


<210> 8108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 8108
aaaatattaa aatgtcaata                                                   20


<210> 8109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 8109
tgtcaatatc agaaacactc                                                   20


<210> 8110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 8110
gcagaggtac ttgaaataac                                                   20


<210> 8111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 8111
ataattataa aacatacacc                                                   20


<210> 8112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 8112
catctgacaa gttcattctt                                                   20


<210> 8113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8113
catagaggag gtaaagaaca                                                   20


<210> 8114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 8114
ggtcataaat atgcagtttg                                                   20


<210> 8115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 8115
agcatgctga ataaggtagc                                                   20


<210> 8116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 8116
gaaatgctta caacttttcc                                                   20


<210> 8117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 8117
ttcttcttag aggactgaaa                                                   20


<210> 8118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8118
atgaaagtct gcaggaggaa                                                   20


<210> 8119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 8119
ggaaaaagaa aggatgaaat                                                   20


<210> 8120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 8120
ctacatggca gtgttatatt                                                   20


<210> 8121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 8121
ccttccatta cactgcattt                                                   20


<210> 8122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 8122
ctgcatttta agaaagccaa                                                   20


<210> 8123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 8123
atatttttat cataaaacct                                                   20


<210> 8124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 8124
ttgaaggaac gtcagagttg                                                   20


<210> 8125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 8125
ccatagcttt agtattcagt                                                   20


<210> 8126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 8126
aagcaaccta aagcattggc                                                   20


<210> 8127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 8127
ctaaagcatt ggcttagaaa                                                   20


<210> 8128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 8128
tgtatgcggc agcgttccct                                                   20


<210> 8129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 8129
ctaccctgga ggctgaggtg                                                   20


<210> 8130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 8130
aaagactaat acatgtatag                                                   20


<210> 8131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 8131
ttttgtattc aaggaacttc                                                   20


<210> 8132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 8132
acttcctaga aaaatgaaaa                                                   20


<210> 8133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 8133
caagatgtga cagatatcat                                                   20


<210> 8134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 8134
tacagaaaaa tataaagggg                                                   20


<210> 8135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 8135
tatacttgaa attttaataa                                                   20


<210> 8136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 8136
aaatttcaca attgcttcaa                                                   20


<210> 8137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 8137
cattccatgc tcatgtgtag                                                   20


<210> 8138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 8138
aatggaacag aacagagccc                                                   20


<210> 8139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 8139
tatctgatct ttgacaaacc                                                   20


<210> 8140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 8140
ggaaaactgg ctagccatat                                                   20


<210> 8141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 8141
ctaaaaccat aaaaacccta                                                   20


<210> 8142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAT

<400> 8142
atctgacaaa aggctaatat                                                   20


<210> 8143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 8143
aatgaactca aacaaattta                                                   20


<210> 8144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 8144
gctcatcatc actggccatc                                                   20


<210> 8145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 8145
gagataccat ctcacaccag                                                   20


<210> 8146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 8146
acaggtgctg gagaggatgt                                                   20


<210> 8147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 8147
gattcctcag ggatctagaa                                                   20


<210> 8148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 8148
ccaacaatga tagactggat                                                   20


<210> 8149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 8149
tcattctcag taaactatca                                                   20


<210> 8150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 8150
ttttatacag aaggaagcca                                                   20


<210> 8151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8151
taagaggcct ggatggaaac                                                   20


<210> 8152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 8152
agacttaact atttgcctgc                                                   20


<210> 8153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAT

<400> 8153
actacaaaag gtaacatgtt                                                   20


<210> 8154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 8154
ccttctaacc atctttatac                                                   20


<210> 8155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAT

<400> 8155
cattaatgtt ctaataacat                                                   20


<210> 8156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 8156
tactctttgg cccataggct                                                   20


<210> 8157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8157
caataggcag tgatattttg                                                   20


<210> 8158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 8158
tatttaattt tctgaatagt                                                   20


<210> 8159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 8159
gtagcacatt tgatttcctt                                                   20


<210> 8160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 8160
ttctagcttc tgatttaaag                                                   20


<210> 8161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 8161
attacaaagt tgaaatattg                                                   20


<210> 8162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 8162
gccacaaacc ttcaacttgt                                                   20


<210> 8163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 8163
aagttaggat aaaggttttt                                                   20


<210> 8164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAT

<400> 8164
gattccatct tatgaaatgt                                                   20


<210> 8165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 8165
tgtccagaat aggcaaatcc                                                   20


<210> 8166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 8166
aaactactat gaatatgcat                                                   20


<210> 8167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 8167
aaaatatgtg aaaattgtcc                                                   20


<210> 8168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 8168
gtagacatac tgtggctctt                                                   20


<210> 8169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 8169
ctggagggta ccatctcttt                                                   20


<210> 8170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 8170
tctctttcaa gaattatttg                                                   20


<210> 8171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAT

<400> 8171
tgcacatgct caacacagct                                                   20


<210> 8172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 8172
aaggcaaaat cgaaaaagat                                                   20


<210> 8173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8173
gtcaaacctc actagtaatc                                                   20


<210> 8174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 8174
gctgctcggg aggctgaggc                                                   20


<210> 8175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 8175
atgtcatgtt tttctatcca                                                   20


<210> 8176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8176
catgtttttc tatccagaag                                                   20


<210> 8177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 8177
ttactatgat tgtatcttct                                                   20


<210> 8178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 8178
ctcaccatta atctcatatt                                                   20


<210> 8179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 8179
tacagtctag aacactcatc                                                   20


<210> 8180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 8180
agaacactca tctgagaatg                                                   20


<210> 8181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 8181
tggcaaatat gtgatgtaga                                                   20


<210> 8182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAA

<400> 8182
attatttatt caataatgtt                                                   20


<210> 8183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 8183
cataaatatt aatagattat                                                   20


<210> 8184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 8184
aacagaccaa acttttaact                                                   20


<210> 8185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 8185
aagttaaagt tagtattcct                                                   20


<210> 8186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 8186
ttgtgaaaca aaaaatttca                                                   20


<210> 8187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAT

<400> 8187
tacccaaaag gggcacttta                                                   20


<210> 8188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 8188
ccagtgagca ttctcaggtg                                                   20


<210> 8189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 8189
agatttttct atatatttta                                                   20


<210> 8190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 8190
caaaataaaa cttagaagat                                                   20


<210> 8191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAA

<400> 8191
aaataataaa caaagtaatg                                                   20


<210> 8192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 8192
gaaagtttag agcattaaca                                                   20


<210> 8193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 8193
aaaataagat aactaactaa                                                   20


<210> 8194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 8194
tcaatgcttt cagtgtgatg                                                   20


<210> 8195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 8195
acaaaatata tttctaggta                                                   20


<210> 8196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 8196
aaaaagtact tctaaaacac                                                   20


<210> 8197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 8197
ggcatgaact tgaacaactg                                                   20


<210> 8198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 8198
cctggctaaa gtttaagtaa                                                   20


<210> 8199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 8199
taaaggtata aatccaaccc                                                   20


<210> 8200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 8200
aatccaaccc atagaattac                                                   20


<210> 8201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 8201
aaacataact gcttggaatt                                                   20


<210> 8202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAA

<400> 8202
gcttggaatt tgagaatggg                                                   20


<210> 8203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 8203
aatttgagaa tggggcagaa                                                   20


<210> 8204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 8204
ataaattcct cattttcaaa                                                   20


<210> 8205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 8205
ctcattttca aattagaaag                                                   20


<210> 8206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 8206
tagagataaa aaggaaaata                                                   20


<210> 8207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8207
ttatacctct ctcttgagcc                                                   20


<210> 8208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 8208
accaacaaac agctgcttaa                                                   20


<210> 8209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 8209
ggttgtcaag agtgtatata                                                   20


<210> 8210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 8210
aggttttatt attcaaaagg                                                   20


<210> 8211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 8211
gaaaaaattc aattcaaaaa                                                   20


<210> 8212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 8212
aaaaaaaatc tatcaattca                                                   20


<210> 8213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8213
agtctctatt atgttcaatt                                                   20


<210> 8214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8214
gaatgtgtaa caacattcaa                                                   20


<210> 8215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8215
aagaaaggac aaagatacta                                                   20


<210> 8216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 8216
attactttat gaaacactac                                                   20


<210> 8217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 8217
gtctaggaca agttcaggag                                                   20


<210> 8218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAT

<400> 8218
taaacaatac aagagtatcc                                                   20


<210> 8219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAT

<400> 8219
gctcaaagga ttgggtcact                                                   20


<210> 8220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 8220
cactgcagaa tttcctttct                                                   20


<210> 8221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 8221
ccaacacttg gtttatcttc                                                   20


<210> 8222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 8222
atcattaatg taatctctga                                                   20


<210> 8223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 8223
tgtaatctct gaacagaata                                                   20


<210> 8224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8224
aatgatccct tccttcaagc                                                   20


<210> 8225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 8225
atgaaagcta tatttattta                                                   20


<210> 8226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 8226
gataactttt gacatctctt                                                   20


<210> 8227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 8227
ctactcagga ggctgaggca                                                   20


<210> 8228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 8228
gctttgaaaa tgtcacttct                                                   20


<210> 8229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 8229
taaagcattc tcaaggcacc                                                   20


<210> 8230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 8230
gtaccattga tactatgtga                                                   20


<210> 8231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 8231
ttatagcctt aatctaacca                                                   20


<210> 8232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 8232
catcaaaaac aaggaaagcc                                                   20


<210> 8233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 8233
agcctgggtg agatcttgaa                                                   20


<210> 8234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 8234
agcaaaagga aatcacagat                                                   20


<210> 8235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 8235
tttgatcaat aggagatcca                                                   20


<210> 8236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 8236
gaatctgtgt gtattttctt                                                   20


<210> 8237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8237
tgtgaggtaa catagagata                                                   20


<210> 8238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 8238
ataagacttc ccatgataaa                                                   20


<210> 8239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 8239
ataggccttc tcccatgaaa                                                   20


<210> 8240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 8240
tctgttctat gtcttggcac                                                   20


<210> 8241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 8241
gaatagctct acagtttaga                                                   20


<210> 8242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 8242
ggtgcgaaac gattgaatct                                                   20


<210> 8243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 8243
tccaagccag gattttgtgt                                                   20


<210> 8244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 8244
aagaataaat gctacacaac                                                   20


<210> 8245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 8245
cttaccattg agagatcctt                                                   20


<210> 8246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 8246
aaacttttca ttttctgtct                                                   20


<210> 8247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAA

<400> 8247
aggaggcagc tgtaatatgg                                                   20


<210> 8248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 8248
ataatctttt tataatctta                                                   20


<210> 8249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 8249
cagcttcatt taactaatta                                                   20


<210> 8250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 8250
acatggtttg tttcgtttgt                                                   20


<210> 8251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 8251
ttttctgaaa actcaagttg                                                   20


<210> 8252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 8252
aaggaaaaga tcttagacaa                                                   20


<210> 8253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 8253
caaaaagaat ggaaacacag                                                   20


<210> 8254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 8254
atggaaacac agcaagaaat                                                   20


<210> 8255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 8255
acagcaagaa atgaagaata                                                   20


<210> 8256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 8256
taaaattttt tctctgttgt                                                   20


<210> 8257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 8257
gaccttttaa taactgaaaa                                                   20


<210> 8258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 8258
ataacttgct agcacaatta                                                   20


<210> 8259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 8259
tatgagagca atgagaacac                                                   20


<210> 8260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 8260
ggcacctaac ttggacttag                                                   20


<210> 8261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 8261
tggtcaggga aggaagatga                                                   20


<210> 8262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 8262
ttactctcaa cttttccaaa                                                   20


<210> 8263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 8263
atacaactgg gggaggaggt                                                   20


<210> 8264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 8264
tcaattttgt aatggagaag                                                   20


<210> 8265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 8265
aactggatta ttacacaatc                                                   20


<210> 8266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 8266
gagatgagtg tcttcttctt                                                   20


<210> 8267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 8267
tataaaaagt caaaaatgac                                                   20


<210> 8268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAT

<400> 8268
tatccaatct tccttcttat                                                   20


<210> 8269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 8269
tgggtctatg tacagctata                                                   20


<210> 8270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 8270
atcaatatct ttgcttaata                                                   20


<210> 8271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8271
acctcagaag tagtgattta                                                   20


<210> 8272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAT

<400> 8272
acataatgca gtctgtaaat                                                   20


<210> 8273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 8273
ttcaaaaata tttttgtcct                                                   20


<210> 8274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 8274
tcaagaaaat atggcaaatc                                                   20


<210> 8275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 8275
atccaagaat atatttattt                                                   20


<210> 8276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 8276
aagttattaa ataataattg                                                   20


<210> 8277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 8277
ggagttacca gagttagcaa                                                   20


<210> 8278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 8278
aagatatgga atgctatgag                                                   20


<210> 8279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 8279
tgggttattt taaaagtcag                                                   20


<210> 8280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 8280
gaatttgtga gaccttttct                                                   20


<210> 8281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 8281
tttcggtgct ttaaataaac                                                   20


<210> 8282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 8282
tcttcattag tagagtctga                                                   20


<210> 8283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 8283
tgaacagaat aaatgctgaa                                                   20


<210> 8284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 8284
tgctgtttga gcagcgtcat                                                   20


<210> 8285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 8285
cttgtaagca agtcttttta                                                   20


<210> 8286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 8286
gtagattttg tcctatagca                                                   20


<210> 8287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 8287
agttattgac tggtttattt                                                   20


<210> 8288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 8288
cagaaacatg gccactggaa                                                   20


<210> 8289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAT

<400> 8289
gtcattattt cctaatgaat                                                   20


<210> 8290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 8290
tgttccctta gccaaacctg                                                   20


<210> 8291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAA

<400> 8291
tttaatcacc aattactgtc                                                   20


<210> 8292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 8292
aaaatcgatt aagctgaggt                                                   20


<210> 8293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8293
taagggacta tttccttaac                                                   20


<210> 8294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 8294
ttccttaaca aagaaagtgg                                                   20


<210> 8295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAA

<400> 8295
gtctagaggg taaatttaca                                                   20


<210> 8296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 8296
gatgaggctt aaagaacagg                                                   20


<210> 8297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 8297
cccaagaggc taatggtttt                                                   20


<210> 8298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 8298
taccttggaa acacaagggg                                                   20


<210> 8299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAT

<400> 8299
agttaatgca tataaacact                                                   20


<210> 8300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 8300
cactcttccc aggatacaag                                                   20


<210> 8301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8301
cactgcatta agggggttcc                                                   20


<210> 8302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 8302
aattatataa ccatagtaat                                                   20


<210> 8303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAT

<400> 8303
tttcgtgacc tgacaattgg                                                   20


<210> 8304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 8304
gaatacaaat cagttatttt                                                   20


<210> 8305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 8305
ctgttactcc ccaggccagt                                                   20


<210> 8306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAA

<400> 8306
atgttttaaa actttaaaat                                                   20


<210> 8307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 8307
tttattcagc agacttgagt                                                   20


<210> 8308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 8308
tctctgatat ataatgtatc                                                   20


<210> 8309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 8309
ggggaaagac atgcatgttc                                                   20


<210> 8310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 8310
tgcatgttct tagaattttg                                                   20


<210> 8311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 8311
aaatagatga gaaccttagt                                                   20


<210> 8312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 8312
gaagttacac gggtagtctg                                                   20


<210> 8313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8313
cagtattaca gcttgaaaac                                                   20


<210> 8314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 8314
acagcttgaa aacaaagaaa                                                   20


<210> 8315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 8315
cctcaaataa cacatcttgg                                                   20


<210> 8316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 8316
acatcttggg aagaatgtac                                                   20


<210> 8317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 8317
ttttataatt tataattatc                                                   20


<210> 8318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 8318
ctaagttttg tctatttttt                                                   20


<210> 8319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 8319
cttcatgtac aaatatatgc                                                   20


<210> 8320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 8320
taattgacct taccttttta                                                   20


<210> 8321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 8321
gcaaatggaa atttcacatt                                                   20


<210> 8322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 8322
ttctcccact ttataccgtc                                                   20


<210> 8323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 8323
taatttgata gaagacaatg                                                   20


<210> 8324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 8324
ttttgctatg acacagtaca                                                   20


<210> 8325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 8325
gtcatttcat tcaggaaata                                                   20


<210> 8326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 8326
aaaggtttcg gttttaacct                                                   20


<210> 8327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAT

<400> 8327
attgttttgt aagcatactt                                                   20


<210> 8328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 8328
attatattat accttatatt                                                   20


<210> 8329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 8329
aattatgatg ccctataaat                                                   20


<210> 8330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 8330
tgcatttact ttaaaatcgt                                                   20


<210> 8331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 8331
aagattaaac cattagagtc                                                   20


<210> 8332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 8332
gaaaattttc tacctcacgt                                                   20


<210> 8333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 8333
aaaattgaaa cttttaaaga                                                   20


<210> 8334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 8334
atagatttgt gataacctat                                                   20


<210> 8335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8335
taatcaatgt tttatttcaa                                                   20


<210> 8336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8336
ctagattact tttctgggaa                                                   20


<210> 8337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 8337
taggatggta ttaagaacta                                                   20


<210> 8338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8338
agtgagattg tgtttcaaaa                                                   20


<210> 8339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8339
gattgtgttt caaaaaaaga                                                   20


<210> 8340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8340
tgtttcaaaa aaagaaaaga                                                   20


<210> 8341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8341
caaaaaaaga aaagaaaaga                                                   20


<210> 8342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8342
aaagaaaaga aaagaaaaga                                                   20


<210> 8343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 8343
agataacaga ttaggatcat                                                   20


<210> 8344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 8344
aagtacatat gcctttctat                                                   20


<210> 8345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8345
aactaaacta gcacagacaa                                                   20


<210> 8346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 8346
tattgatcac atcacattac                                                   20


<210> 8347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 8347
gtcaacatga atatgaaata                                                   20


<210> 8348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8348
tatgaaatat gagaaaccac                                                   20


<210> 8349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 8349
cttgtaattt gtacattcgc                                                   20


<210> 8350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 8350
gtccttcaag tcatccgcca                                                   20


<210> 8351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8351
aagagtactg ggcttggtca                                                   20


<210> 8352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8352
aatcctttgt gcaaacaggg                                                   20


<210> 8353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 8353
atcatagctg tatgattaga                                                   20


<210> 8354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 8354
atgtgaagca gcagtgtaag                                                   20


<210> 8355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8355
actacatttc agacctcatg                                                   20


<210> 8356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 8356
gtggtactca atgttctttc                                                   20


<210> 8357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 8357
tgaattgtgg tgtgcataac                                                   20


<210> 8358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 8358
gattgatata aaactaagtt                                                   20


<210> 8359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 8359
aacaaaaaca gatataattg                                                   20


<210> 8360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 8360
atctttttat tttcatccca                                                   20


<210> 8361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 8361
atagaagttt atcatgttag                                                   20


<210> 8362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 8362
cttgaaacaa caaagatgga                                                   20


<210> 8363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 8363
tcgtgaaaag agtaaacaag                                                   20


<210> 8364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 8364
aaacaactca atactgtcca                                                   20


<210> 8365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 8365
actaaatatg gagcaggtgc                                                   20


<210> 8366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 8366
gaaaagccag gagaggaaca                                                   20


<210> 8367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 8367
catcagaaag acacaaaaat                                                   20


<210> 8368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 8368
agacatttgc acaatagttt                                                   20


<210> 8369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 8369
ttacagtgat gctgaactaa                                                   20


<210> 8370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 8370
taggacatca agtaattatt                                                   20


<210> 8371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 8371
gggttcatga atcattgctc                                                   20


<210> 8372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAA

<400> 8372
cccaggggat aggttttcat                                                   20


<210> 8373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 8373
agccttgagt tctgtgctat                                                   20


<210> 8374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 8374
aggcatttaa agttcatgcc                                                   20


<210> 8375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 8375
tgtacatttt tcctacaaac                                                   20


<210> 8376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 8376
atttttccta caaactaaga                                                   20


<210> 8377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 8377
accatttact ccctgggaac                                                   20


<210> 8378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 8378
actctcattt tgtcttatcc                                                   20


<210> 8379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 8379
aagaccagcc tgaccaacat                                                   20


<210> 8380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 8380
ctcctcggaa ggctgaggca                                                   20


<210> 8381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 8381
cttactttaa aaagaaggaa                                                   20


<210> 8382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 8382
aaagaaggaa acagaaaaag                                                   20


<210> 8383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8383
caaaatgtaa ggaaccaatg                                                   20


<210> 8384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8384
gtaaggaacc aatgaaagaa                                                   20


<210> 8385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 8385
ttaggagtat ttcaatggtc                                                   20


<210> 8386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 8386
agtactgtta attctgaaaa                                                   20


<210> 8387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 8387
gagaccagtc tgaccaacat                                                   20


<210> 8388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 8388
ctactcagga ggctgaggca                                                   20


<210> 8389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 8389
ttatgtaagg agagagatta                                                   20


<210> 8390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 8390
taggtatccc tatatgtgcc                                                   20


<210> 8391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 8391
tctctgctga ttttaggaat                                                   20


<210> 8392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 8392
attttaggaa ttcagaaatt                                                   20


<210> 8393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 8393
agacacattg aattgagctc                                                   20


<210> 8394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 8394
cttagaattt tgtctgtaaa                                                   20


<210> 8395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 8395
aagatggtta taactaagag                                                   20


<210> 8396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 8396
cgacacaaag gcttccaagg                                                   20


<210> 8397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 8397
aagcatgaaa agcctaaaaa                                                   20


<210> 8398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 8398
cacacatcag ggtggtgaaa                                                   20


<210> 8399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 8399
agggtggtga aatgagaaag                                                   20


<210> 8400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 8400
ttcagagaag cagagctggt                                                   20


<210> 8401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 8401
atcagtcttt gctatggaca                                                   20


<210> 8402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 8402
atcatcaacc tgataccatc                                                   20


<210> 8403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAT

<400> 8403
cagtaaaaaa tgtaagtgag                                                   20


<210> 8404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 8404
cttcattcta tggcgtttct                                                   20


<210> 8405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 8405
gccctaaacc cgtaaaatgg                                                   20


<210> 8406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 8406
gccctacttt taacagcctg                                                   20


<210> 8407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 8407
tgcattcctt tgctacaaga                                                   20


<210> 8408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 8408
gactgcagta agactgaaac                                                   20


<210> 8409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 8409
cttacattct gtactgaagt                                                   20


<210> 8410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 8410
tgtttccaaa aaaaaaaaaa                                                   20


<210> 8411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 8411
tctacagctc cccactatgt                                                   20


<210> 8412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 8412
taactatcat tgattttaca                                                   20


<210> 8413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 8413
cgatcaagta tttaattgtt                                                   20


<210> 8414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAA

<400> 8414
aatccaagac acatttattt                                                   20


<210> 8415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 8415
aatatagcaa attttcattg                                                   20


<210> 8416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 8416
aattttcatt gggagaaaat                                                   20


<210> 8417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 8417
aatttagaaa actgaaaagc                                                   20


<210> 8418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 8418
taaatgaaat taacctattc                                                   20


<210> 8419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 8419
tacatactga caaaatgttt                                                   20


<210> 8420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 8420
aaactggttt tcaaaaatga                                                   20


<210> 8421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 8421
tatttctggg aaacataggc                                                   20


<210> 8422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 8422
gcattcttat atttattttt                                                   20


<210> 8423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 8423
accctaactc tgctgatctt                                                   20


<210> 8424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 8424
ctcctgtgtt ttatattatc                                                   20


<210> 8425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8425
atattatcca tctcaggtga                                                   20


<210> 8426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8426
ccatctcagg tgaaaagaaa                                                   20


<210> 8427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 8427
gtatgccaag tataatatca                                                   20


<210> 8428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 8428
cttaaaataa ttattatttc                                                   20


<210> 8429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 8429
tatagtattc ctcaagttta                                                   20


<210> 8430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 8430
aagaccagcc tgaccaacat                                                   20


<210> 8431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8431
ctgtctcaaa aaaaaaaaaa                                                   20


<210> 8432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8432
aaaaaaaaag aaaaaaaaaa                                                   20


<210> 8433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 8433
tacagcatgt ataaaggaag                                                   20


<210> 8434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 8434
acccttattt aaataattag                                                   20


<210> 8435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 8435
caaaacatca acatgattta                                                   20


<210> 8436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 8436
aaattcccca taaatgaaag                                                   20


<210> 8437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 8437
ctgtcttata aagttatcat                                                   20


<210> 8438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 8438
ttataaagtt atcatgtaga                                                   20


<210> 8439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CGAGAAT

<400> 8439
aaagctaatg ttcttaggaa                                                   20


<210> 8440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 8440
atatatttgc ttactttata                                                   20


<210> 8441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 8441
cttcttaggg agctttcaac                                                   20


<210> 8442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8442
attggaatat catgggaacc                                                   20


<210> 8443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 8443
aataataaaa tgatcgaaag                                                   20


<210> 8444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAT

<400> 8444
tgatgaccct ctaggactga                                                   20


<210> 8445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 8445
tccagaactt aatgctaaag                                                   20


<210> 8446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAT

<400> 8446
tttttgatga agacattgtt                                                   20


<210> 8447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAT

<400> 8447
ttactttctg ccattttggg                                                   20


<210> 8448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 8448
ataaatagga ttggagtcat                                                   20


<210> 8449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 8449
acaggatcac aaatgaatag                                                   20


<210> 8450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 8450
gcctaaacat ttgctttatc                                                   20


<210> 8451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 8451
ccacaaggat tgtctaaaaa                                                   20


<210> 8452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 8452
taaatctaag attctaaata                                                   20


<210> 8453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 8453
tcattgatct acttgaccgt                                                   20


<210> 8454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 8454
tgatttaatc atatctagga                                                   20


<210> 8455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8455
aaagttttaa tactggtata                                                   20


<210> 8456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 8456
gagttagaac tgtaaatttc                                                   20


<210> 8457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8457
aaccaaaagc acggtcaaca                                                   20


<210> 8458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 8458
ttgtgcatca aagaacacta                                                   20


<210> 8459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 8459
aaaaggcaat ccatatgatg                                                   20


<210> 8460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8460
atttgaaaag acatttttcc                                                   20


<210> 8461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8461
tgtttaaaaa aaaaaaagga                                                   20


<210> 8462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 8462
agaaacattg acaagggtgt                                                   20


<210> 8463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 8463
gtggttcctc aaaaaattaa                                                   20


<210> 8464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAT

<400> 8464
gttccactta catgaggtac                                                   20


<210> 8465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 8465
cctagaatag tcacattcat                                                   20


<210> 8466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAT

<400> 8466
tagtcacatt catagagaaa                                                   20


<210> 8467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAA

<400> 8467
cgtgttttga gatccgtaag                                                   20


<210> 8468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 8468
tatgcagtac cactatttca                                                   20


<210> 8469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 8469
ccccaaatag taagaggttc                                                   20


<210> 8470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 8470
ccaatccatt acagacagga                                                   20


<210> 8471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 8471
gacaaaaaca ttatttttgt                                                   20


<210> 8472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 8472
acattatttt tgtatagaaa                                                   20


<210> 8473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 8473
tggttttatg ttacccatgt                                                   20


<210> 8474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAA

<400> 8474
gttagtaatc cctacaaaat                                                   20


<210> 8475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAT

<400> 8475
gcaattgctg ttttttgtga                                                   20


<210> 8476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8476
gaagaaggaa gagagggaaa                                                   20


<210> 8477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 8477
aatatttgta ctcctccaat                                                   20


<210> 8478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAT

<400> 8478
ttccctgttt cttctccatt                                                   20


<210> 8479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 8479
cctcaggaat tggtgtccaa                                                   20


<210> 8480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 8480
ttaagggtta aacatatttg                                                   20


<210> 8481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8481
tataagattt ctttcctata                                                   20


<210> 8482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 8482
ctacttggga ggctgaggca                                                   20


<210> 8483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 8483
ctactcggga ggctgaggca                                                   20


<210> 8484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 8484
ctcggtctca aaaaaaaaaa                                                   20


<210> 8485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 8485
atttacagga aagcaatatt                                                   20


<210> 8486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 8486
caagtttgta aatggggtaa                                                   20


<210> 8487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 8487
tacactgtct attagacttg                                                   20


<210> 8488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 8488
atataaattt taattttttt                                                   20


<210> 8489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAT

<400> 8489
gctactcgga ggctgaggca                                                   20


<210> 8490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 8490
aaataaaaaa taaaaaaaaa                                                   20


<210> 8491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8491
gagagaagaa ggaaaaaaaa                                                   20


<210> 8492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TCAGAAA

<400> 8492
attgtatttt gataaatgat                                                   20


<210> 8493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8493
aaaatccaag gagacatttt                                                   20


<210> 8494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8494
gatagttcat ctcctgtgtt                                                   20


<210> 8495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 8495
ctctatagaa ctaaaaagat                                                   20


<210> 8496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 8496
gggtaagtga taccttcaat                                                   20


<210> 8497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAT

<400> 8497
caatgaagaa atttcatttt                                                   20


<210> 8498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 8498
agatgtcata atacttctgt                                                   20


<210> 8499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 8499
tgcctctctg aaccttcctt                                                   20


<210> 8500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 8500
aagcatctat gtttatttta                                                   20


<210> 8501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 8501
atttgtggtc actgcctttc                                                   20


<210> 8502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 8502
atcacctaca ctgataaaag                                                   20


<210> 8503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 8503
aaatgcttga caaataaaaa                                                   20


<210> 8504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 8504
ggttaatatg ctttattctg                                                   20


<210> 8505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8505
atgctgtaac aagcagtatg                                                   20


<210> 8506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 8506
gcaggagcac cttaatgaga                                                   20


<210> 8507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAT

<400> 8507
aggatggtat tgctttgtat                                                   20


<210> 8508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 8508
tatagagaat gaattgcagg                                                   20


<210> 8509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 8509
aatttggtgg ccgtgtagat                                                   20


<210> 8510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 8510
catctgagac gtatgatgaa                                                   20


<210> 8511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 8511
cagataatga agatgggagg                                                   20


<210> 8512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAT

<400> 8512
aattattatc attatgacat                                                   20


<210> 8513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 8513
ttacaagatc atgacttgtc                                                   20


<210> 8514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 8514
cttttgcata actaatagga                                                   20


<210> 8515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 8515
tctacttttt tccttgccac                                                   20


<210> 8516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 8516
aaaaaatctc accataatta                                                   20


<210> 8517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 8517
ttaaatagtg gaaaaaatct                                                   20


<210> 8518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8518
aatatattta aataacaagg                                                   20


<210> 8519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 8519
tttaaataac aaggaaagaa                                                   20


<210> 8520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8520
aataacaagg aaagaaagag                                                   20


<210> 8521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 8521
tttatcttgt ctacagggaa                                                   20


<210> 8522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 8522
ttgtctacag ggaagaagaa                                                   20


<210> 8523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAT

<400> 8523
tacagggaag aagaaataga                                                   20


<210> 8524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 8524
aataaataaa taatctgcgc                                                   20


<210> 8525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAA

<400> 8525
taacaactct gctagcgtaa                                                   20


<210> 8526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8526
ccctccccac agaagcagca                                                   20


<210> 8527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAT

<400> 8527
catccccacc cagtgcacct                                                   20


<210> 8528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GCAGAAT

<400> 8528
ctttcctccc ttcctgctca                                                   20


<210> 8529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GGAGAAA

<400> 8529
gtgtggcttg gtggggagct                                                   20


<210> 8530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 8530
ttttctttcg aagatgcagt                                                   20


<210> 8531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8531
agaggaggtc ctaggtgggg                                                   20


<210> 8532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 8532
ggttgaatta tctttctcaa                                                   20


<210> 8533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 8533
acaggaaatt tccaccaagg                                                   20


<210> 8534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CAAGAAT

<400> 8534
acataaccgc tactcccaca                                                   20


<210> 8535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAT

<400> 8535
cccattatca acattcccca                                                   20


<210> 8536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ACAGAAT

<400> 8536
tatcctatag ttgcaataat                                                   20


<210> 8537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8537
tgagagtatg tttagttttt                                                   20


<210> 8538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAT

<400> 8538
ttatgccttt gctgttatat                                                   20


<210> 8539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAA

<400> 8539
ttcttgctct tttggcagcc                                                   20


<210> 8540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 8540
aattttatct tggtttaaac                                                   20


<210> 8541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 8541
actgaccttc cgtaacttag                                                   20


<210> 8542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAT

<400> 8542
ctaacatcat acaatccata                                                   20


<210> 8543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAT

<400> 8543
aatccatacc agaataggaa                                                   20


<210> 8544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TGAGAAA

<400> 8544
aagaatttta tttcccttag                                                   20


<210> 8545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TTAGAAA

<400> 8545
ttttctctaa ttaaatagga                                                   20


<210> 8546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: TAAGAAA

<400> 8546
tgcacggcaa tattacaaag                                                   20


<210> 8547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 8547
attattctgt tgtgaaaata                                                   20


<210> 8548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8548
gaacttcaaa ttataactaa                                                   20


<210> 8549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAT

<400> 8549
caaattataa ctaaaaagaa                                                   20


<210> 8550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 8550
tgatgcttaa tgaaacaact                                                   20


<210> 8551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 8551
cgtggtctgg atttttttgg                                                   20


<210> 8552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAA

<400> 8552
tttggccaga aaactgatgt                                                   20


<210> 8553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GAAGAAT

<400> 8553
ttaattgatt acttattcct                                                   20


<210> 8554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 8554
aagacagtga tccctagaga                                                   20


<210> 8555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AAAGAAA

<400> 8555
cagtgatccc tagagaagag                                                   20


<210> 8556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CCAGAAA

<400> 8556
gaagatggaa acatgaagag                                                   20


<210> 8557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CTAGAAT

<400> 8557
agtttgatag gctgagggag                                                   20


<210> 8558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: GTAGAAA

<400> 8558
agagagtata ccagagatct                                                   20


<210> 8559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: AGAGAAA

<400> 8559
aaacaaaaat accctaagcc                                                   20


<210> 8560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: CGAGAAA

<400> 8560
ctaacaatgg agatatgtac                                                   20


<210> 8561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNAGAAW; 
      PAM sequence: ATAGAAA

<400> 8561
gtgtctaatc atacctaaac                                                   20


<210> 8562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 8562
tgtctataaa agtatgaatc                                                   20


<210> 8563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 8563
ctgacaatgt ctataaaagt                                                   20


<210> 8564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 8564
agtggctgtc ctgtgcatgg                                                   20


<210> 8565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 8565
gagctggata attctttgtt                                                   20


<210> 8566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 8566
tggcaatctt gatatttgag                                                   20


<210> 8567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 8567
gacatttatt tctctaaggc                                                   20


<210> 8568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 8568
tctttcacat ggtaagttga                                                   20


<210> 8569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 8569
catgtctttc acatggtaag                                                   20


<210> 8570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 8570
aatagttttc tttctgtttg                                                   20


<210> 8571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 8571
acatttccct gcttaaaatt                                                   20


<210> 8572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 8572
ttctcagtac agtagccaga                                                   20


<210> 8573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 8573
tctattctca gtacagtagc                                                   20


<210> 8574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 8574
tgtggatttt ggtattctca                                                   20


<210> 8575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 8575
tataagagat ttgagcatct                                                   20


<210> 8576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 8576
ggtaatttta aactatatag                                                   20


<210> 8577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 8577
tccatatgct gagtactaca                                                   20


<210> 8578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 8578
aaacttgaat tttccatatg                                                   20


<210> 8579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 8579
aaagccccaa aaggcaaaac                                                   20


<210> 8580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 8580
atctgtggat tcaaccaatt                                                   20


<210> 8581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 8581
atatccatgg tttctgatct                                                   20


<210> 8582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 8582
gtctctcttc ttttttctat                                                   20


<210> 8583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 8583
tctaacagtt cccgaggctg                                                   20


<210> 8584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 8584
tcataataat ataccataga                                                   20


<210> 8585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 8585
cttaaagcaa tagcaggagc                                                   20


<210> 8586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 8586
ttgcagaaga catgagactc                                                   20


<210> 8587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 8587
tgcattatat atttcactct                                                   20


<210> 8588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 8588
ctatgtcaat acatttaagg                                                   20


<210> 8589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 8589
gcctttaaaa tgtaggccaa                                                   20


<210> 8590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 8590
gtaattttct caaagtcaaa                                                   20


<210> 8591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 8591
atttgtgatc atttgttaca                                                   20


<210> 8592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 8592
gaacagaaaa aataagtgga                                                   20


<210> 8593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 8593
taacagaaca gaaaaaataa                                                   20


<210> 8594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 8594
atatcttgct catataagaa                                                   20


<210> 8595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 8595
ctgctcattt ttatatgaga                                                   20


<210> 8596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 8596
taaatatgtg agaacataat                                                   20


<210> 8597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 8597
aattatatcc agtgaatatt                                                   20


<210> 8598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 8598
ttatgggaaa attatatcca                                                   20


<210> 8599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 8599
ttttagtgat gtgtaaaatt                                                   20


<210> 8600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 8600
ctgcatcatt gcactttagc                                                   20


<210> 8601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 8601
atgcacacag gaaatgaaac                                                   20


<210> 8602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGAT

<400> 8602
tacatactag ctagagcaga                                                   20


<210> 8603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 8603
aacccaagca aaatgagctg                                                   20


<210> 8604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 8604
gcaaaataga attataatca                                                   20


<210> 8605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 8605
gcaatagcca ctctgcaaaa                                                   20


<210> 8606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 8606
gtggttctta ccatttttag                                                   20


<210> 8607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 8607
tttagctact tttgagattt                                                   20


<210> 8608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 8608
agtataacta tagtgcccaa                                                   20


<210> 8609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 8609
caatattttc tctattttat                                                   20


<210> 8610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 8610
acaggaacaa tgcactcttc                                                   20


<210> 8611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 8611
tgaaaattta tattagtagt                                                   20


<210> 8612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 8612
tcattatgtg gttgtaatga                                                   20


<210> 8613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 8613
cttatctata aaatgaggag                                                   20


<210> 8614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 8614
gccatgaccc tatgagtttg                                                   20


<210> 8615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 8615
cccagttaag ccatgaccct                                                   20


<210> 8616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 8616
catacataat ggctaagagc                                                   20


<210> 8617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 8617
attctaccct tacaaccaca                                                   20


<210> 8618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 8618
ctgtatgaca cagaagtagc                                                   20


<210> 8619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 8619
aaagacaagg acaaagaatc                                                   20


<210> 8620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 8620
gggaaacaaa gacaaggaca                                                   20


<210> 8621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 8621
accataggtg ggtaaagtca                                                   20


<210> 8622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 8622
ttcagttaga ataaccatag                                                   20


<210> 8623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 8623
cacgtatttt ctgtttcagt                                                   20


<210> 8624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 8624
gacacattgt aatataatct                                                   20


<210> 8625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 8625
tctatgaatg ctcaaaatgt                                                   20


<210> 8626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 8626
tttacaaatt tcatagatct                                                   20


<210> 8627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 8627
atatcataaa gctgtttaca                                                   20


<210> 8628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 8628
atgaaaataa ataaatagcc                                                   20


<210> 8629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 8629
tcttcttgag gaaaacaatc                                                   20


<210> 8630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 8630
aggatggcca gggaattggc                                                   20


<210> 8631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 8631
caactaaatt aggatggcca                                                   20


<210> 8632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 8632
gaaagaaggg ccaactaaat                                                   20


<210> 8633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 8633
gttttgatag ctttattaaa                                                   20


<210> 8634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 8634
aaatacttag catgatttta                                                   20


<210> 8635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 8635
ttacctagtt tgcaaaagat                                                   20


<210> 8636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TCGGAT

<400> 8636
caggtttgaa cacaaatctt                                                   20


<210> 8637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 8637
gtcatgacct gccaacatgc                                                   20


<210> 8638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGGT

<400> 8638
tatttaaatt tttgtagata                                                   20


<210> 8639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 8639
tctcgctctg tcacccaggc                                                   20


<210> 8640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 8640
ttacactgaa gaacttaact                                                   20


<210> 8641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 8641
tatatattta cgtttgtttc                                                   20


<210> 8642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 8642
ctcacaaata taactgcatt                                                   20


<210> 8643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 8643
aatttaacat caccttaaat                                                   20


<210> 8644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 8644
atttttaaat acattcaatt                                                   20


<210> 8645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 8645
aaagaatgag atcagaagtc                                                   20


<210> 8646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 8646
gaaacaaaga tttatggtta                                                   20


<210> 8647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 8647
tctggcaatt taaaaagaaa                                                   20


<210> 8648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 8648
caaaaattga gctacacagg                                                   20


<210> 8649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 8649
ttttttcgtg agtttatttc                                                   20


<210> 8650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 8650
taaccataat gctttttttc                                                   20


<210> 8651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 8651
aattatggaa gtaatctttt                                                   20


<210> 8652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 8652
gaataaaaaa gcattgaaat                                                   20


<210> 8653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 8653
tacacagata tgtgtttagt                                                   20


<210> 8654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 8654
ttcatatccc tttttgttca                                                   20


<210> 8655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 8655
acaaggataa gacttacctt                                                   20


<210> 8656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 8656
atcttgactc acatgccaac                                                   20


<210> 8657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 8657
tatgtgccta taaaatgcca                                                   20


<210> 8658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 8658
agaagtaatg gacattagtt                                                   20


<210> 8659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 8659
tctgccttgt catcttttca                                                   20


<210> 8660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 8660
gaatcgtaag agaactctgt                                                   20


<210> 8661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 8661
ttttgcactg atgattcttt                                                   20


<210> 8662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 8662
ccacactaaa acggaaacaa                                                   20


<210> 8663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 8663
ttttgggtga gagtggggag                                                   20


<210> 8664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 8664
ttacaaagcg tgttttgggt                                                   20


<210> 8665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 8665
ttgcttttac aaagcgtgtt                                                   20


<210> 8666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CCGGAT

<400> 8666
ctgcccatgg ttagtggtga                                                   20


<210> 8667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 8667
acaaagtcca gctcattgcc                                                   20


<210> 8668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 8668
tctctgattt tgcagctgcc                                                   20


<210> 8669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 8669
tcccgatgcg acccagttta                                                   20


<210> 8670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 8670
aaagtactga acctctgagt                                                   20


<210> 8671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 8671
ctgaagaaag tactgaacct                                                   20


<210> 8672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 8672
tgtacattgc agtcatactg                                                   20


<210> 8673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 8673
gactgtggta acccatctgt                                                   20


<210> 8674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 8674
tacaacctct gctggctggg                                                   20


<210> 8675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 8675
aaattacaac ctctgctggc                                                   20


<210> 8676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 8676
gcctatgtta aaaaggaaga                                                   20


<210> 8677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 8677
atgttcatct acgccatctt                                                   20


<210> 8678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGAT

<400> 8678
cgtctagtca aaggagcaaa                                                   20


<210> 8679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CCGAAT

<400> 8679
atccgtcttg ccaggattgg                                                   20


<210> 8680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 8680
ttccgagtga tccgtcttgc                                                   20


<210> 8681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CCGAGT

<400> 8681
tttgtgtccc ctaccctgtt                                                   20


<210> 8682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 8682
agttgacaga taaaactgtt                                                   20


<210> 8683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 8683
ctgtcttgaa ttcataagaa                                                   20


<210> 8684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 8684
aaaaaaaaaa aaaaactgtc                                                   20


<210> 8685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 8685
tactcgggag gctgaggcag                                                   20


<210> 8686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GCGGAT

<400> 8686
actttgggag gccgaggcgg                                                   20


<210> 8687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 8687
taatgttagt catttctctt                                                   20


<210> 8688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 8688
gtattgcttg aattttctat                                                   20


<210> 8689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 8689
ttagcattta acggtattgc                                                   20


<210> 8690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 8690
acaaaaaaag cttatataac                                                   20


<210> 8691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CGGGAT

<400> 8691
gctggagaat catttgatcc                                                   20


<210> 8692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 8692
tactctggag gctgaggctg                                                   20


<210> 8693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 8693
tatgcatact atatgctata                                                   20


<210> 8694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 8694
cacatactat gtatatagta                                                   20


<210> 8695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 8695
aatggtagca ctcaatactg                                                   20


<210> 8696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 8696
tttggtaaaa aactataaag                                                   20


<210> 8697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 8697
aacaaaacac aaggaaaatt                                                   20


<210> 8698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 8698
agaagttaaa aacaaccaat                                                   20


<210> 8699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 8699
aattgttctt ataaattaat                                                   20


<210> 8700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 8700
cataacagtt aaggccgaga                                                   20


<210> 8701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 8701
ttactgtgtg aaaagatcac                                                   20


<210> 8702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 8702
aaaagctcag tgggtttgaa                                                   20


<210> 8703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 8703
tgttcaaata taaaagctca                                                   20


<210> 8704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 8704
aaattcatct ggaagaaaat                                                   20


<210> 8705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 8705
aatgagtctt tttatgtagt                                                   20


<210> 8706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 8706
taaattcaag gaaaatatca                                                   20


<210> 8707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 8707
aagaaagcta aaataattga                                                   20


<210> 8708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 8708
gagacttctg aagaaaactt                                                   20


<210> 8709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 8709
caactaaaaa taaattcaat                                                   20


<210> 8710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 8710
aacttgttca tatattgaaa                                                   20


<210> 8711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 8711
aggtacatat ataaaaacaa                                                   20


<210> 8712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 8712
tattaagtca ggaaaaaaaa                                                   20


<210> 8713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 8713
aaatgtatta aaatttaggt                                                   20


<210> 8714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 8714
taaaattgag tgccacataa                                                   20


<210> 8715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 8715
catgacttag aatcataaaa                                                   20


<210> 8716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 8716
aggttcaagg ttgcatgact                                                   20


<210> 8717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 8717
tttaggattg tatttctttt                                                   20


<210> 8718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 8718
acatatcttg caaagtattt                                                   20


<210> 8719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 8719
cagccatggt gttcatgtct                                                   20


<210> 8720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 8720
tgaatttgtg aaaattcttc                                                   20


<210> 8721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 8721
tattaatagc cagaatatct                                                   20


<210> 8722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 8722
ttaatgataa tattaatagc                                                   20


<210> 8723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 8723
tgtgtcttgg aaaaccaatg                                                   20


<210> 8724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 8724
tctctcatac tacagtgttt                                                   20


<210> 8725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 8725
tgagtaagtc agtacaatga                                                   20


<210> 8726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 8726
tcttgaacac aaatttactc                                                   20


<210> 8727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 8727
tatgctcaag gaagtatatg                                                   20


<210> 8728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 8728
tatttttcag attttatttt                                                   20


<210> 8729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 8729
tgattatctc cattgtaggt                                                   20


<210> 8730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 8730
actactactt cactgtagga                                                   20


<210> 8731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 8731
cagacactac tacttcactg                                                   20


<210> 8732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 8732
ttttataatc cttttcactg                                                   20


<210> 8733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 8733
catatgactg aagttttata                                                   20


<210> 8734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 8734
taaccatgat ggtagaaaag                                                   20


<210> 8735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 8735
ttctttgcag aacaaaatcc                                                   20


<210> 8736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 8736
ttaatgcaca tctttaattt                                                   20


<210> 8737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGGT

<400> 8737
caaaagccaa ttcctcgacc                                                   20


<210> 8738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 8738
ctataatgca atgaaaaagc                                                   20


<210> 8739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 8739
aacactgatt agcacaccaa                                                   20


<210> 8740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 8740
tctttgtagt aattgtgaat                                                   20


<210> 8741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 8741
ttattctctt tgtagtaatt                                                   20


<210> 8742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 8742
tccttcacat cccttgtaag                                                   20


<210> 8743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 8743
agtcttccta tccatgagca                                                   20


<210> 8744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 8744
gtaatgccat tttcatgata                                                   20


<210> 8745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 8745
gtagcttgat ggggatagca                                                   20


<210> 8746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGAT

<400> 8746
aaagtcagtg gtagcttgat                                                   20


<210> 8747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 8747
ccagctttgt tctttttgct                                                   20


<210> 8748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 8748
ttgtttttgt gaggtttgtc                                                   20


<210> 8749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 8749
ttttgtacaa ggtgtaagga                                                   20


<210> 8750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 8750
atttaagtct ttaatccatc                                                   20


<210> 8751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 8751
atattgccta gagtttcttc                                                   20


<210> 8752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 8752
atgtcctgaa tgatattgcc                                                   20


<210> 8753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 8753
tctttgccca tgcctatgtc                                                   20


<210> 8754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 8754
gatattagcc cttttgtcag                                                   20


<210> 8755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 8755
gtttaagttc tttgtagatt                                                   20


<210> 8756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 8756
atcctttgcc cactttttga                                                   20


<210> 8757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 8757
tttctagttt tagattcttg                                                   20


<210> 8758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 8758
tatacccagt aatgagattg                                                   20


<210> 8759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 8759
gtagcatgat ttacaatccc                                                   20


<210> 8760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 8760
ggttccaagt ctttgctatt                                                   20


<210> 8761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 8761
agtctattat tgatggacat                                                   20


<210> 8762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 8762
cgtccttgtg atattttgct                                                   20


<210> 8763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 8763
cacttatgag tgagaacatg                                                   20


<210> 8764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 8764
tcattgttca actcccactt                                                   20


<210> 8765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 8765
tattattata ctttaagttc                                                   20


<210> 8766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 8766
aggaataatg gtatattaaa                                                   20


<210> 8767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 8767
tatattcatt ttttatgtaa                                                   20


<210> 8768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 8768
tagaattaaa aaggtagtca                                                   20


<210> 8769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 8769
ttatgttgaa atcctttatt                                                   20


<210> 8770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 8770
tcagtaccta gaaatctatc                                                   20


<210> 8771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 8771
caattggaaa gtccttcagt                                                   20


<210> 8772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 8772
agatgttatg ttatttactg                                                   20


<210> 8773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 8773
ggtgaaatta tagactaatg                                                   20


<210> 8774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 8774
gaaaataaat tcttaattat                                                   20


<210> 8775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 8775
ctgaatatta ccaaatccaa                                                   20


<210> 8776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 8776
aataagtaaa taagaggaag                                                   20


<210> 8777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 8777
tggttaccat taggtgtttg                                                   20


<210> 8778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 8778
tacttgggag gctgagacat                                                   20


<210> 8779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 8779
ctggcagatc acttgaggcc                                                   20


<210> 8780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CCGGAT

<400> 8780
attaaaacac tctaaggtgg                                                   20


<210> 8781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 8781
gcatattaaa tagaggaaag                                                   20


<210> 8782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 8782
atgccttgcc agtaggtgag                                                   20


<210> 8783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 8783
attaatgaac agtaaaggat                                                   20


<210> 8784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 8784
gtccccatta atgaacagta                                                   20


<210> 8785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 8785
tttgattttc tcttcaaagt                                                   20


<210> 8786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 8786
ttcttcatca tattgacaac                                                   20


<210> 8787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 8787
cacccacgca agtttctcta                                                   20


<210> 8788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 8788
tccttccacc taggttttaa                                                   20


<210> 8789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 8789
aaaaaaacta gcctgactta                                                   20


<210> 8790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 8790
tgatgaggtg gttttactta                                                   20


<210> 8791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 8791
attacaaatt tgagcaacta                                                   20


<210> 8792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 8792
tattagaaca aaagtcatta                                                   20


<210> 8793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 8793
aattgtttca aaccaagtaa                                                   20


<210> 8794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 8794
taaattagcc cctagaaagg                                                   20


<210> 8795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 8795
tgaataaatt agcccctaga                                                   20


<210> 8796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 8796
aaagtggtat cttgatgaaa                                                   20


<210> 8797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 8797
ctggacccta gtgcagcaca                                                   20


<210> 8798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 8798
ttcagtgctc catatgaggc                                                   20


<210> 8799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 8799
tcagcctggc tagagatact                                                   20


<210> 8800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 8800
cattggtgtc tgtgcattgg                                                   20


<210> 8801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GCGGAT

<400> 8801
tttctttagg gtcagtaact                                                   20


<210> 8802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 8802
tttataaatc tctatttctt                                                   20


<210> 8803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 8803
acttcattag gataattatt                                                   20


<210> 8804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 8804
ggtactttgc taaacttcat                                                   20


<210> 8805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 8805
attattgtat tcttcaattc                                                   20


<210> 8806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 8806
gtctgctatt gaatcctcta                                                   20


<210> 8807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 8807
cagtttgatc aagtctgcta                                                   20


<210> 8808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 8808
atcctttacc cagtttttga                                                   20


<210> 8809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 8809
tttctagttc tagatccttg                                                   20


<210> 8810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 8810
tatacccagt catgggatgg                                                   20


<210> 8811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 8811
tttgggtata tacccagtca                                                   20


<210> 8812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 8812
gcagcatgat ttataatcct                                                   20


<210> 8813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 8813
ggttccaagt ctttgctatt                                                   20


<210> 8814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 8814
tttccttgcg atagtttgct                                                   20


<210> 8815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 8815
tcattgttca attcccacct                                                   20


<210> 8816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 8816
ttttattata ctttaagttt                                                   20


<210> 8817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 8817
ttttttggtg tccatctttt                                                   20


<210> 8818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 8818
atttcttctt gctccactga                                                   20


<210> 8819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 8819
tttgggattc tttgagtttc                                                   20


<210> 8820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 8820
tttgtcctat ttgggattct                                                   20


<210> 8821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 8821
ttctttagat ttgtcctatt                                                   20


<210> 8822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 8822
cgctcagccc ctcaaagtgc                                                   20


<210> 8823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 8823
gcctcagcct cccgagtagc                                                   20


<210> 8824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CCGAGT

<400> 8824
attctctctg cctcagcctc                                                   20


<210> 8825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 8825
ctcactgcaa cttccacctc                                                   20


<210> 8826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 8826
tttcaccgtg ttgcccaggc                                                   20


<210> 8827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 8827
tctttctttt ttttccgaga                                                   20


<210> 8828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 8828
agtttttttc tttaagtatt                                                   20


<210> 8829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 8829
aatgatttat ataatactat                                                   20


<210> 8830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 8830
ttgacattta acttttatat                                                   20


<210> 8831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 8831
ttttatttct gtatttttac                                                   20


<210> 8832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 8832
ttaactgtct tcttttgtga                                                   20


<210> 8833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 8833
tatctggaga cagcatataa                                                   20


<210> 8834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ACGAGT

<400> 8834
tatgttttct taaatctgaa                                                   20


<210> 8835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 8835
tcctcaattt tggtatccct                                                   20


<210> 8836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 8836
atgtgaaatc cacagataca                                                   20


<210> 8837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 8837
gattgaaaac actgtattca                                                   20


<210> 8838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 8838
acagggtgtc ctctgtgtct                                                   20


<210> 8839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 8839
tattttggct gatataatta                                                   20


<210> 8840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 8840
ataattgtta tatcttcttg                                                   20


<210> 8841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 8841
cgtatttaca tgctttgatg                                                   20


<210> 8842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TCGGGT

<400> 8842
gttctgttca ttattgcaag                                                   20


<210> 8843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 8843
gatggtatat taagatgctg                                                   20


<210> 8844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 8844
cctgatatgt gatctatcct                                                   20


<210> 8845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 8845
tgtttaattt ccacatattt                                                   20


<210> 8846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 8846
ttgacccatt gctttttcaa                                                   20


<210> 8847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 8847
ttttcttagt tatgcttgct                                                   20


<210> 8848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 8848
tcatttctgg ttttacatat                                                   20


<210> 8849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 8849
cttggtaggt tgtatatttt                                                   20


<210> 8850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 8850
gtcctgtaca tttctttttt                                                   20


<210> 8851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 8851
aagttttaag agagtttgag                                                   20


<210> 8852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 8852
tttcctcttc aaagttttaa                                                   20


<210> 8853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 8853
tctttgtctg gctttgatat                                                   20


<210> 8854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 8854
atgagttttt ctactggatt                                                   20


<210> 8855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 8855
ggtgtgcatg agtttttcta                                                   20


<210> 8856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 8856
ttttctgtcc tctggtgtgc                                                   20


<210> 8857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 8857
ctttttctac ccattttgat                                                   20


<210> 8858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 8858
gctcagggtg gggttagtgc                                                   20


<210> 8859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 8859
gtaaggcact gtgctcaggg                                                   20


<210> 8860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 8860
caaatgtaag gcactgtgct                                                   20


<210> 8861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 8861
ttccttaaat taaaaaaaag                                                   20


<210> 8862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 8862
tgtgtcaggg cctataaaag                                                   20


<210> 8863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 8863
tcccaggaat taaagcttct                                                   20


<210> 8864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 8864
ttggaagatg gtctgatccc                                                   20


<210> 8865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 8865
aagccaggga agaaggcgtg                                                   20


<210> 8866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 8866
aaaaagaaag attgtagagt                                                   20


<210> 8867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 8867
aaaaaaaaaa agaaagattg                                                   20


<210> 8868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 8868
tactcgggag gctgaggcag                                                   20


<210> 8869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GCGGAT

<400> 8869
actttgggag gccgaggcgg                                                   20


<210> 8870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 8870
ataaatatct gttagatcta                                                   20


<210> 8871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 8871
gaatatgtat tttgttgctg                                                   20


<210> 8872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 8872
agtgtttcat gtgatttgag                                                   20


<210> 8873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 8873
ctaacatgtg atctatcctg                                                   20


<210> 8874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 8874
tgtttaattt ccacgtaatt                                                   20


<210> 8875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGAT

<400> 8875
ttcttccttc tgcaaagttt                                                   20


<210> 8876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 8876
tctttcattt cagatattgt                                                   20


<210> 8877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 8877
attcatatta cttctttaaa                                                   20


<210> 8878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 8878
attttttgga agaatttgag                                                   20


<210> 8879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 8879
cctccttttc aattttttgg                                                   20


<210> 8880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 8880
tataatactg gcctcataaa                                                   20


<210> 8881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 8881
cttttctggt agcatactct                                                   20


<210> 8882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 8882
tttttggatc tatgttcatc                                                   20


<210> 8883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 8883
taatatattg ttgtgaattt                                                   20


<210> 8884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 8884
cagtttgcta atatattgtt                                                   20


<210> 8885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 8885
atgatgtttt aaatgtgcta                                                   20


<210> 8886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 8886
ataaatccca agtaatcatg                                                   20


<210> 8887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 8887
gattttatta tgaacatatg                                                   20


<210> 8888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 8888
tcctgcctaa ttgctatgga                                                   20


<210> 8889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 8889
ctttttcctg cctaattgct                                                   20


<210> 8890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 8890
tttatttctt gctttcttac                                                   20


<210> 8891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 8891
acagttctca gtagagtgtt                                                   20


<210> 8892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 8892
tcagttttaa cagttctcag                                                   20


<210> 8893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 8893
ttttgcaaac tgcaacttta                                                   20


<210> 8894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 8894
ttaatttctt aatttctttg                                                   20


<210> 8895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 8895
tattttgatg ctgttttaaa                                                   20


<210> 8896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 8896
cattgaatct gtagattatt                                                   20


<210> 8897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 8897
gaattttgat agggattgca                                                   20


<210> 8898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 8898
actgacatta gaattttgat                                                   20


<210> 8899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 8899
atttctgtga aaactgacat                                                   20


<210> 8900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 8900
tttttatttt attcaaatgt                                                   20


<210> 8901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 8901
agctttatat tttgaaatga                                                   20


<210> 8902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 8902
aatcaattga ctataaataa                                                   20


<210> 8903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 8903
caatttcatt cttttgcata                                                   20


<210> 8904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 8904
tcttttgtta cctgtgcttt                                                   20


<210> 8905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 8905
tgagcttttt atgtataatg                                                   20


<210> 8906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 8906
gtttattgat tttctaggtg                                                   20


<210> 8907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 8907
ggtgtgaggt aatatttcat                                                   20


<210> 8908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 8908
cattttcact aacaatgtat                                                   20


<210> 8909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 8909
tatacctaga agtggaattg                                                   20


<210> 8910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 8910
taccactata tacctagaag                                                   20


<210> 8911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 8911
aacgatttta attcctctaa                                                   20


<210> 8912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 8912
aataatgctg aaatgaacat                                                   20


<210> 8913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 8913
gatgggtaca ggttgcatgt                                                   20


<210> 8914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 8914
ctttattcat tcacctgttg                                                   20


<210> 8915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 8915
ttagtttcat tcatgttggg                                                   20


<210> 8916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 8916
tcctttagtt tcattcatgt                                                   20


<210> 8917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 8917
ttttatttta ctttaagttc                                                   20


<210> 8918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 8918
gtattgccta ggctgtcttc                                                   20


<210> 8919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 8919
tctttgccca tgcctatgtc                                                   20


<210> 8920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 8920
atttaagttc cttatagatt                                                   20


<210> 8921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 8921
atcctttgcc cactttttaa                                                   20


<210> 8922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 8922
cacacagtct tccattatgg                                                   20


<210> 8923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 8923
tttctgtctt taggtctttg                                                   20


<210> 8924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 8924
ccagtaatgg gattgctggg                                                   20


<210> 8925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 8925
tatacccagt aatgggattg                                                   20


<210> 8926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 8926
tttaggtata tacccagtaa                                                   20


<210> 8927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 8927
gattctatgt ctttgccatt                                                   20


<210> 8928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 8928
agtctatcac tgatggtcat                                                   20


<210> 8929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 8929
ggatatgatc tcgttttttt                                                   20


<210> 8930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 8930
gctccattca tgtccctgca                                                   20


<210> 8931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGGT

<400> 8931
tacataggta aacatgtcat                                                   20


<210> 8932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 8932
taagttcagg ggtacatgta                                                   20


<210> 8933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGGT

<400> 8933
ttgactttta ttttaagttc                                                   20


<210> 8934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 8934
acaaaaattg tgcttattta                                                   20


<210> 8935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 8935
tatttgcatc tatgttcatc                                                   20


<210> 8936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 8936
aaatttgtca aatgcttctt                                                   20


<210> 8937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 8937
aacagcatta atgcatttaa                                                   20


<210> 8938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 8938
tgatacacat ggcacaaaga                                                   20


<210> 8939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 8939
cttatgggat cacagtactg                                                   20


<210> 8940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 8940
tataatgaac ataaacctta                                                   20


<210> 8941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 8941
ctataacaga ataccacaga                                                   20


<210> 8942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 8942
atccatttgt gctactataa                                                   20


<210> 8943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 8943
attgaatacg atgttagctg                                                   20


<210> 8944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 8944
agtttttcag tttttcacca                                                   20


<210> 8945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 8945
ctgtgttaaa tacaagtggc                                                   20


<210> 8946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 8946
aacacttttt tctttcagat                                                   20


<210> 8947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 8947
ttcctgatgt gtggagtctt                                                   20


<210> 8948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 8948
taacagattt tcctgatgtg                                                   20


<210> 8949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 8949
tcttttgatg ttatcataaa                                                   20


<210> 8950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 8950
agtcatttaa ttcgtgaata                                                   20


<210> 8951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 8951
aatattaagt catttaattc                                                   20


<210> 8952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 8952
tattgaattc acagatcact                                                   20


<210> 8953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 8953
ggattttgat atgtactgta                                                   20


<210> 8954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 8954
attttagtaa ataatgctat                                                   20


<210> 8955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 8955
ttgtggttcc atatgaattt                                                   20


<210> 8956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 8956
agagtctttt gtggttccat                                                   20


<210> 8957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 8957
ttaagattgc tttggctatt                                                   20


<210> 8958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 8958
ctgcactctg gcctgggcaa                                                   20


<210> 8959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 8959
tgggaggatc actgaagccc                                                   20


<210> 8960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 8960
tacttaggag cctgaggtgg                                                   20


<210> 8961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 8961
ctggaggatc acttgtggcc                                                   20


<210> 8962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 8962
aactcgggag gctaaggctg                                                   20


<210> 8963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 8963
gaaatgagga cctgtgggga                                                   20


<210> 8964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 8964
tatgagttaa ctatttatgc                                                   20


<210> 8965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 8965
tcttggcacc cctgttgaat                                                   20


<210> 8966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 8966
gtgtattctt ggcacccctg                                                   20


<210> 8967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 8967
agttttccca acattatttg                                                   20


<210> 8968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 8968
tcaattttat ttttttatat                                                   20


<210> 8969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 8969
ttttgtgtat ggtataatat                                                   20


<210> 8970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 8970
gtttaaatgt ttaatctatt                                                   20


<210> 8971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 8971
ttttgctctt gtttgaattt                                                   20


<210> 8972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 8972
ttgtctattt ttgctcttgt                                                   20


<210> 8973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 8973
taggttgctt tttcaccctc                                                   20


<210> 8974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 8974
gcaggagttc cctatatatt                                                   20


<210> 8975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 8975
tgcatgcctt cttaagttgc                                                   20


<210> 8976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 8976
gccctcatta cagtttttat                                                   20


<210> 8977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 8977
accttggcct cccaaagtgc                                                   20


<210> 8978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 8978
tggagtttca ccattttggc                                                   20


<210> 8979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 8979
ttttgtattt tcagtagaga                                                   20


<210> 8980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 8980
gcctcagctt cccaagtagc                                                   20


<210> 8981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 8981
gtctcactct gtcaccaggc                                                   20


<210> 8982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 8982
gtttgtttgt ttgtttttga                                                   20


<210> 8983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 8983
gtctcggcct cccaaagtgc                                                   20


<210> 8984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 8984
cggggtttca ccctgttagc                                                   20


<210> 8985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CGGGGT

<400> 8985
ttttgtattt ttagtagaga                                                   20


<210> 8986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CCGGGT

<400> 8986
ctcactgcaa gctccgcctc                                                   20


<210> 8987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 8987
tttcgctctg tcgcccaggc                                                   20


<210> 8988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CGGAGT

<400> 8988
tgttgttttt ttttttgaga                                                   20


<210> 8989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 8989
aacacctatt atcttttgat                                                   20


<210> 8990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 8990
gaagtaagga ctctgagatc                                                   20


<210> 8991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 8991
catttaggtt gttttcatat                                                   20


<210> 8992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 8992
ggatttcctt ctttataagg                                                   20


<210> 8993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 8993
attcaagttg ctgcatatgg                                                   20


<210> 8994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 8994
ttttagttac ttcaccgaag                                                   20


<210> 8995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 8995
ccattcttct ctctgtttcc                                                   20


<210> 8996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 8996
taattgaaac tttattccca                                                   20


<210> 8997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 8997
ctgacctttt ctgaatgatt                                                   20


<210> 8998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 8998
cttttatttt ctgacctttt                                                   20


<210> 8999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 8999
actgcaggaa gtaaaatagg                                                   20


<210> 9000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 9000
ttctactgca ggaagtaaaa                                                   20


<210> 9001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 9001
attcctcagt cttccctgca                                                   20


<210> 9002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 9002
tacaaaagag aataataatt                                                   20


<210> 9003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 9003
taaatggtag aattacaaaa                                                   20


<210> 9004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9004
gatctttgga gactaaatgg                                                   20


<210> 9005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 9005
gagataaagg agtctaattc                                                   20


<210> 9006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 9006
ttgtgatttg caagagataa                                                   20


<210> 9007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9007
cattaaaaca ttttagaggg                                                   20


<210> 9008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 9008
tgttccatta aaacatttta                                                   20


<210> 9009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 9009
attagtcctg tgtgtcaatg                                                   20


<210> 9010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9010
tttcattatg gatctagctc                                                   20


<210> 9011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 9011
agctaaaaag tagtttcatt                                                   20


<210> 9012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9012
ttcatatatg ttgagtaggg                                                   20


<210> 9013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 9013
tggtgtttca ttcatatatg                                                   20


<210> 9014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 9014
gatgaggttt taacctgcct                                                   20


<210> 9015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGAT

<400> 9015
aaaagaggca gcaattcagg                                                   20


<210> 9016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9016
aaacagaaat gaatgagcaa                                                   20


<210> 9017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9017
ccacatggag tgaaacagaa                                                   20


<210> 9018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 9018
aaaagaatgg ctaacccaca                                                   20


<210> 9019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9019
atgtagcaac ggagaggcaa                                                   20


<210> 9020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9020
agtaaaaata gatgctgcta                                                   20


<210> 9021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 9021
caaaaaatat acatgacagt                                                   20


<210> 9022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 9022
agtatgtgat gaaggttaga                                                   20


<210> 9023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TCGAGT

<400> 9023
gacttaccca aggtcatata                                                   20


<210> 9024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 9024
caatcacaaa agtattatta                                                   20


<210> 9025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 9025
aggtcacatt ctgaagtgct                                                   20


<210> 9026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 9026
tagtaaggat gccagtcaca                                                   20


<210> 9027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 9027
tgtctttctc ctctactagt                                                   20


<210> 9028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 9028
gtttctttga cctacgagaa                                                   20


<210> 9029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9029
gtaatgaaaa ttaagacttg                                                   20


<210> 9030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9030
tcaaggagtt tatgtcatag                                                   20


<210> 9031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 9031
agatatggtt cctgagctca                                                   20


<210> 9032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 9032
tttattttgt gtaatatata                                                   20


<210> 9033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9033
ccaatgtttc ctatagagga                                                   20


<210> 9034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 9034
tttttccaat gtttcctata                                                   20


<210> 9035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 9035
atatttttca ttgtaatgaa                                                   20


<210> 9036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 9036
ttttgtcgtc tttatcatct                                                   20


<210> 9037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9037
ggtagacaag cagcccaaat                                                   20


<210> 9038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9038
accatgtgaa aaagaaaata                                                   20


<210> 9039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9039
tttacctagg atagcactgt                                                   20


<210> 9040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 9040
tcttaaatcc tatgtttacc                                                   20


<210> 9041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 9041
tacatgttga ataaattgtt                                                   20


<210> 9042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9042
aagtatgtaa tgaatacatg                                                   20


<210> 9043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9043
aattaaataa taagtatgta                                                   20


<210> 9044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9044
catagtatgt cacttagtta                                                   20


<210> 9045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CGGAAT

<400> 9045
aaatataata aagatgtatt                                                   20


<210> 9046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 9046
tacagtttaa aacaccttgg                                                   20


<210> 9047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 9047
tttttacagt ttaaaacacc                                                   20


<210> 9048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9048
tttgtctaat ctataattta                                                   20


<210> 9049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 9049
ctgatagtag cctagtggtt                                                   20


<210> 9050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 9050
cgattattat gtatgcagca                                                   20


<210> 9051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 9051
attcttaaag gcaactttta                                                   20


<210> 9052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9052
aactctgttt atggctattt                                                   20


<210> 9053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9053
ctttacatta aatggacatg                                                   20


<210> 9054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 9054
taagatttag aatgttactt                                                   20


<210> 9055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9055
aattaactgg gactaagatt                                                   20


<210> 9056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 9056
cttcctgctt cacactatga                                                   20


<210> 9057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 9057
aagcatgggt tctgttgcat                                                   20


<210> 9058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 9058
ttcctacatg aataagaagc                                                   20


<210> 9059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9059
ttcctagaac atgttcctac                                                   20


<210> 9060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 9060
tgcttgggag gctgaggcag                                                   20


<210> 9061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 9061
taaaaataca aaaaaattag                                                   20


<210> 9062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 9062
ggtgggcaga tcatgaggtc                                                   20


<210> 9063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 9063
attttaatag atattggacg                                                   20


<210> 9064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 9064
agttgtaagt gtcccatttc                                                   20


<210> 9065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9065
gttccgaatg ttttgccctt                                                   20


<210> 9066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CCGAAT

<400> 9066
aagtcaagtt ccaaatcgtt                                                   20


<210> 9067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 9067
tgagtgtatt aacaccacag                                                   20


<210> 9068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 9068
tttgtttgct ggcaagttct                                                   20


<210> 9069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 9069
tggctgatat tcagcatcat                                                   20


<210> 9070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9070
taggagcaat tccttccatc                                                   20


<210> 9071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 9071
cttttgaata ctaggtcgtt                                                   20


<210> 9072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9072
taatcatgct tttctttctt                                                   20


<210> 9073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 9073
agagtaggca tttaataaac                                                   20


<210> 9074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 9074
gcttggcaca ctgctgagtg                                                   20


<210> 9075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 9075
ttgtcttgct tggcacactg                                                   20


<210> 9076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 9076
atttgtaagc ctggtgatca                                                   20


<210> 9077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 9077
ttatacattt cttttttttc                                                   20


<210> 9078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 9078
atctttaatg ctggtaataa                                                   20


<210> 9079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 9079
caccaatagt ttctctatgg                                                   20


<210> 9080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 9080
tggagaatgt ctcaaaaaaa                                                   20


<210> 9081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 9081
agattctcaa tccttttgtg                                                   20


<210> 9082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 9082
cgtagaacca gccaaatcta                                                   20


<210> 9083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 9083
aggcttacat ataaagtatt                                                   20


<210> 9084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 9084
ctgaaaagca gaaataaaga                                                   20


<210> 9085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 9085
gaattgccct ggatgaaaac                                                   20


<210> 9086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 9086
taaatgccac aggaattgcc                                                   20


<210> 9087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 9087
tggagagtgt taaatgccac                                                   20


<210> 9088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 9088
taagtaaata agaaaatctg                                                   20


<210> 9089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 9089
tttaacacat ttgtacttga                                                   20


<210> 9090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9090
aatctttaac acatttgtac                                                   20


<210> 9091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 9091
cttaatacat tgcagaaaag                                                   20


<210> 9092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9092
ccatgactac catggcagag                                                   20


<210> 9093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 9093
atgacccatg actaccatgg                                                   20


<210> 9094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9094
tgtaagaatc tgatgaaagt                                                   20


<210> 9095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9095
tttgaggtca catagactgt                                                   20


<210> 9096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 9096
tggtcagtga ctagatgtat                                                   20


<210> 9097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9097
taccacatgg tagggaggca                                                   20


<210> 9098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 9098
tttcagacat ttcatgactg                                                   20


<210> 9099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 9099
tgatacagga atatacagta                                                   20


<210> 9100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 9100
acaagggcac ataatgatac                                                   20


<210> 9101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 9101
cccggtcccc aaagagtgag                                                   20


<210> 9102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 9102
tagaccccgg tccccaaaga                                                   20


<210> 9103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 9103
tacatagacc ccggtcccca                                                   20


<210> 9104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 9104
gtgttgtgat ataaaaaaca                                                   20


<210> 9105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 9105
gcatattgta gtcagcttgt                                                   20


<210> 9106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 9106
catgccgcag ggctattttg                                                   20


<210> 9107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 9107
tacaggtgaa ttggatgcag                                                   20


<210> 9108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 9108
ttatctgtat tacaggtgaa                                                   20


<210> 9109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 9109
gttctttatc tgtattacag                                                   20


<210> 9110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9110
cttaattttt tgagcattaa                                                   20


<210> 9111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9111
tttgtgcaga aaggtggtat                                                   20


<210> 9112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 9112
ccaggatggg gataagaaac                                                   20


<210> 9113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGAT

<400> 9113
tgagtcagaa actccaggat                                                   20


<210> 9114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 9114
acctactgag tcagaaactc                                                   20


<210> 9115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 9115
tggatctcac cccagaccta                                                   20


<210> 9116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 9116
aaaaaaaaaa aagcaaattc                                                   20


<210> 9117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9117
tactagggag gctgaggcag                                                   20


<210> 9118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 9118
gacggacgga tcatgaggtc                                                   20


<210> 9119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ACGGAT

<400> 9119
caaacttatt aaaaagacgg                                                   20


<210> 9120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 9120
ccgtccacca ggagacataa                                                   20


<210> 9121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 9121
gctattttat gcctctgttc                                                   20


<210> 9122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 9122
aactaccata acctagcttt                                                   20


<210> 9123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9123
gcagagacaa acaagttata                                                   20


<210> 9124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 9124
cttaatttgc acttaggctg                                                   20


<210> 9125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 9125
tttgagaaaa ctaaagctca                                                   20


<210> 9126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 9126
aaataacatt gcaaagtaag                                                   20


<210> 9127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 9127
atatttgttt aagaaactac                                                   20


<210> 9128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 9128
caaacaatag aatgatccaa                                                   20


<210> 9129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9129
tatctaatat tgtcaaacaa                                                   20


<210> 9130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 9130
cagtgcatat tgtttaacaa                                                   20


<210> 9131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9131
ctattatata ttaatatata                                                   20


<210> 9132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 9132
acaatgggta tgtagaaatt                                                   20


<210> 9133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 9133
gggtttaaaa tataaaaaca                                                   20


<210> 9134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 9134
ataatgttct tattttttaa                                                   20


<210> 9135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 9135
ttatctagat ttgaaggaat                                                   20


<210> 9136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 9136
agagccttat ctagatttga                                                   20


<210> 9137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9137
gagttgcttt tagtgagttt                                                   20


<210> 9138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 9138
ttcctgttga gttgctttta                                                   20


<210> 9139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 9139
ataccatctt attgttcctg                                                   20


<210> 9140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9140
atgcatgatt tctattcaaa                                                   20


<210> 9141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 9141
ttaaattttt agatttaata                                                   20


<210> 9142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 9142
atcacacact tcattttgac                                                   20


<210> 9143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9143
acacttttag ggcttagctt                                                   20


<210> 9144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 9144
taagacatag atttagttga                                                   20


<210> 9145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 9145
atactaagac atagatttag                                                   20


<210> 9146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 9146
atttgcccca actcaaaatc                                                   20


<210> 9147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 9147
agggcagaag caatcttgtt                                                   20


<210> 9148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 9148
gataagaact caaatttctt                                                   20


<210> 9149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 9149
ttttccatgg aactaattca                                                   20


<210> 9150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9150
ctacacagga tgtgaggcaa                                                   20


<210> 9151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 9151
agacatcgtc tcctgctaca                                                   20


<210> 9152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9152
cctattcttc cctcgaaaaa                                                   20


<210> 9153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 9153
gacatctgga aatactacat                                                   20


<210> 9154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 9154
tctgctaaat acgtagcttt                                                   20


<210> 9155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 9155
gcaaatttaa gagtggcatg                                                   20


<210> 9156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 9156
gtgaatgact gggcaaattt                                                   20


<210> 9157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 9157
ttaagtggaa aataatggat                                                   20


<210> 9158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 9158
gtgttcttaa gtggaaaata                                                   20


<210> 9159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 9159
attgggaatt aagttccaac                                                   20


<210> 9160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 9160
cctcttaata ctgttacatt                                                   20


<210> 9161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 9161
ggtgttcact gagagccaaa                                                   20


<210> 9162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGGT

<400> 9162
gctcatggca tcacatggcg                                                   20


<210> 9163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 9163
tcttgctggt gggcacacca                                                   20


<210> 9164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 9164
aagctgggaa gtctaaggtg                                                   20


<210> 9165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 9165
tctacctttt attgctgtaa                                                   20


<210> 9166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 9166
gtgtgtgttt atagaaagat                                                   20


<210> 9167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 9167
tgtctgattt ctgcaggctt                                                   20


<210> 9168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 9168
cttatattat ttgctactca                                                   20


<210> 9169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 9169
ctgaatcaga aactctgggg                                                   20


<210> 9170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 9170
acatactgaa tcagaaactc                                                   20


<210> 9171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 9171
gcccccaacc ccaagacata                                                   20


<210> 9172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 9172
atctacagca gttgttcttg                                                   20


<210> 9173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 9173
attttgggac acagatttgg                                                   20


<210> 9174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 9174
caaatataat gcaaagcaca                                                   20


<210> 9175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGGT

<400> 9175
gtgagtataa cctcctgttc                                                   20


<210> 9176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 9176
atttaaagtg atgattctca                                                   20


<210> 9177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CGGGGT

<400> 9177
ctcttaaact gtaaatatga                                                   20


<210> 9178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 9178
aaataagaag aaattataga                                                   20


<210> 9179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 9179
aaaaaatgaa aaatgataaa                                                   20


<210> 9180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TCGGAT

<400> 9180
cctctatgag aattctaact                                                   20


<210> 9181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 9181
ttatcttagg tttcctctat                                                   20


<210> 9182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 9182
ctgcactcca gcttgggcga                                                   20


<210> 9183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 9183
cccggtaggc agaggtttca                                                   20


<210> 9184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9184
tactcaggag gctgaggcag                                                   20


<210> 9185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 9185
caggtggatc acctgaggtc                                                   20


<210> 9186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 9186
actttgagag tccgaggcag                                                   20


<210> 9187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 9187
gcctgtaatc ccagcacttt                                                   20


<210> 9188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 9188
gaattcatac agcatcatat                                                   20


<210> 9189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9189
tatcgagctt ttaagaaaag                                                   20


<210> 9190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 9190
aagtgcttta aaatttaacc                                                   20


<210> 9191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9191
tctcccagtc ttatttttct                                                   20


<210> 9192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9192
tacccattat tatcatttca                                                   20


<210> 9193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 9193
ttcaaagaac tgttgaatac                                                   20


<210> 9194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9194
ataataaatt caaagaactg                                                   20


<210> 9195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 9195
ccagaatggc agtggggcag                                                   20


<210> 9196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9196
tgcgacttgc ccttcatctc                                                   20


<210> 9197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 9197
tgtaaaattg gaagataaga                                                   20


<210> 9198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9198
atttgaatgt cattcttgtt                                                   20


<210> 9199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9199
gattttttaa aaaatatgat                                                   20


<210> 9200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 9200
tgacattgta acatttataa                                                   20


<210> 9201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 9201
ccagtggaaa tatatctgtg                                                   20


<210> 9202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 9202
cttttgagta cattttaaaa                                                   20


<210> 9203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 9203
aattgttgat gtaggtactt                                                   20


<210> 9204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 9204
tcaccaatgc ctggtgttgg                                                   20


<210> 9205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 9205
attctggaaa tgcttctaaa                                                   20


<210> 9206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 9206
aaagaccatt aagattatcc                                                   20


<210> 9207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9207
aagttgtgca tgattgaaac                                                   20


<210> 9208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9208
atttttcctg ttttttttaa                                                   20


<210> 9209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9209
tgtttcagca gtcttagcat                                                   20


<210> 9210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 9210
cagagatcat gagtcttttt                                                   20


<210> 9211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 9211
atgatcaggt gtcagagatc                                                   20


<210> 9212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 9212
aattttaatg gagaaagagg                                                   20


<210> 9213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 9213
tttataacag tggctggcca                                                   20


<210> 9214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 9214
ggtggggaaa aaggggagtg                                                   20


<210> 9215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 9215
tcctactggt ggggaaaaag                                                   20


<210> 9216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 9216
attaacatgg tactaggcac                                                   20


<210> 9217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9217
ctttgaagga taatatatgg                                                   20


<210> 9218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 9218
gaagctttga aggataatat                                                   20


<210> 9219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 9219
tttttagagc tgaagctttg                                                   20


<210> 9220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 9220
ggaagcaccg cattaatgga                                                   20


<210> 9221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 9221
catacacaaa ataggagtaa                                                   20


<210> 9222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 9222
cagaagagca tacacaaaat                                                   20


<210> 9223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 9223
tcttgctctg ttgcccaggc                                                   20


<210> 9224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 9224
tttttttttt ttttttgaga                                                   20


<210> 9225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 9225
ttgactttca ttttatccaa                                                   20


<210> 9226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 9226
taaatataat attaaccacg                                                   20


<210> 9227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 9227
gaacgtagaa taagaagaat                                                   20


<210> 9228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9228
aaagcagaac gtagaataag                                                   20


<210> 9229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9229
agagtattga aagcagaacg                                                   20


<210> 9230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 9230
aaaactgcta aggataattt                                                   20


<210> 9231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 9231
aacagtttcc caaaactgct                                                   20


<210> 9232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9232
ccctctgcac ttcaattcca                                                   20


<210> 9233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 9233
attcctccag aatttggggg                                                   20


<210> 9234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGGT

<400> 9234
gcctgattcc tccagaattt                                                   20


<210> 9235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9235
gatggcttgc ctgattcctc                                                   20


<210> 9236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 9236
ttgtctttgt atttcaagga                                                   20


<210> 9237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 9237
gaagctagaa cccctgtggg                                                   20


<210> 9238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 9238
cagaaataaa tgagtggtaa                                                   20


<210> 9239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 9239
tatacacaaa acagaaataa                                                   20


<210> 9240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 9240
tgttgtggct cctcagaaag                                                   20


<210> 9241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 9241
agtaaatgac agagctatca                                                   20


<210> 9242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 9242
ttattttacc aatgatgaag                                                   20


<210> 9243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9243
agcttatact tattgtgttt                                                   20


<210> 9244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 9244
attacaaaaa aattaaagtt                                                   20


<210> 9245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 9245
gctgactcac atatgtgact                                                   20


<210> 9246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 9246
aaagctctat tttccttacc                                                   20


<210> 9247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 9247
tcactgcaaa cacaaccctg                                                   20


<210> 9248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 9248
gctgaggaac actgagctta                                                   20


<210> 9249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 9249
aatgagtgtg tacacatata                                                   20


<210> 9250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 9250
ggggcattat atgagcctga                                                   20


<210> 9251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 9251
catgggggca ttatatgagc                                                   20


<210> 9252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 9252
acttatgtgt ggaaagtagc                                                   20


<210> 9253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 9253
tggcagaaga tatgaggtgc                                                   20


<210> 9254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 9254
ggttgatctg atactgtttc                                                   20


<210> 9255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 9255
ttgcctcata gacagtcttc                                                   20


<210> 9256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9256
aagtttcatt atactaaaaa                                                   20


<210> 9257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9257
gagagttgaa agagatctag                                                   20


<210> 9258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 9258
cacatacaag cagcttccat                                                   20


<210> 9259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 9259
gggaaaacag atggtagttt                                                   20


<210> 9260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 9260
cagggtctag aaagacgaac                                                   20


<210> 9261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 9261
gaaacgtaaa tggtgctttt                                                   20


<210> 9262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 9262
caaatgagta actgtagagc                                                   20


<210> 9263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 9263
tggagaagag aagaatacaa                                                   20


<210> 9264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9264
ctcagagcaa tggagaagag                                                   20


<210> 9265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 9265
gactcttagt tgactgttag                                                   20


<210> 9266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 9266
ttgcagagaa ttataattct                                                   20


<210> 9267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 9267
cttcaacagt cagtcttgca                                                   20


<210> 9268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 9268
gtcgttggca caattagtcc                                                   20


<210> 9269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 9269
gaaagttcat tggccctagt                                                   20


<210> 9270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 9270
atcagtttgc aaaacaggga                                                   20


<210> 9271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 9271
cagatggcta taatagaaaa                                                   20


<210> 9272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 9272
caggcattat ccttgctgcc                                                   20


<210> 9273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9273
tcatggcaag ttgttttacc                                                   20


<210> 9274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 9274
ctcatgctgc caagttaaca                                                   20


<210> 9275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 9275
tattaaaaat tttatttatt                                                   20


<210> 9276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 9276
tgttgaaatt atttggttga                                                   20


<210> 9277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9277
aattggggat tacagaagac                                                   20


<210> 9278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGAT

<400> 9278
gaggagactg aagagaaatt                                                   20


<210> 9279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 9279
tcagagggtt tttaccatag                                                   20


<210> 9280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 9280
gtttagaaag gtgtatttca                                                   20


<210> 9281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 9281
tttcttttga acttaatttc                                                   20


<210> 9282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 9282
atctggatct tctaatcaag                                                   20


<210> 9283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 9283
aatacttgaa acagtttcat                                                   20


<210> 9284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9284
agtcacattt gtttttaact                                                   20


<210> 9285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9285
acaaaagaat gcgttaatga                                                   20


<210> 9286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9286
atggacaaaa gaatgcgtta                                                   20


<210> 9287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9287
aacaagggtt tgatggacaa                                                   20


<210> 9288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 9288
atacataaaa gatacgtaac                                                   20


<210> 9289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 9289
aaaggaaatc atgtacagag                                                   20


<210> 9290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 9290
gcataacaat ttttgctgcc                                                   20


<210> 9291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 9291
tacttactcc tcaacctcaa                                                   20


<210> 9292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 9292
accagaatcc aaatggtttt                                                   20


<210> 9293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9293
ctccagacag gatactggac                                                   20


<210> 9294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 9294
aactaatctt tccctccaga                                                   20


<210> 9295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9295
ttttatctgc caaatatgtc                                                   20


<210> 9296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 9296
taacatccac ctggtagtcc                                                   20


<210> 9297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CCGAGT

<400> 9297
catctcaaaa tcattacctg                                                   20


<210> 9298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 9298
acccccattt ttaaaatcta                                                   20


<210> 9299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9299
catgtatgct aattattact                                                   20


<210> 9300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CGGAGT

<400> 9300
attgttgttt cagaatgttt                                                   20


<210> 9301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9301
ctcccttaat attgttgttt                                                   20


<210> 9302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9302
ggtctgcttt cagcacacca                                                   20


<210> 9303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9303
atttctgaca gtttaacaac                                                   20


<210> 9304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 9304
gcttttaaca acagacaagc                                                   20


<210> 9305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9305
cctttcctta aggtaagtta                                                   20


<210> 9306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CGGAAT

<400> 9306
ccatacttct gctattcaaa                                                   20


<210> 9307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 9307
tccagagaga ataatccaga                                                   20


<210> 9308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 9308
gcatattact actgtccaga                                                   20


<210> 9309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 9309
atagaccagc atccagaaag                                                   20


<210> 9310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9310
tccagataga ataggccaga                                                   20


<210> 9311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9311
acatacttcc accatccaga                                                   20


<210> 9312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 9312
tgatgtgaaa ttgctaaatg                                                   20


<210> 9313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 9313
tttttaattt ttgtgctatt                                                   20


<210> 9314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 9314
aaacagaatt tcaataatga                                                   20


<210> 9315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9315
attatttgca aatcaaaaaa                                                   20


<210> 9316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9316
gtatatcaaa ttgtttctca                                                   20


<210> 9317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 9317
actataaatt ttactgatat                                                   20


<210> 9318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 9318
taaagagtct ctcttttctt                                                   20


<210> 9319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 9319
ttcactgtag ttacttttta                                                   20


<210> 9320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9320
tcatctaaaa ttttatgagg                                                   20


<210> 9321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9321
tgaaaactca atacttgtta                                                   20


<210> 9322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 9322
taccaggtgc atcttgtcaa                                                   20


<210> 9323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 9323
agaaaataac cttatatcaa                                                   20


<210> 9324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 9324
gcaagcatta cagactcagt                                                   20


<210> 9325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 9325
aagccaagta gaggactatg                                                   20


<210> 9326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 9326
agattatata actctttttg                                                   20


<210> 9327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9327
tccaatgttt atgtaaagta                                                   20


<210> 9328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 9328
agataataat tatttaagta                                                   20


<210> 9329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TCGAAT

<400> 9329
tctgttttta tatcatttta                                                   20


<210> 9330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 9330
ttccctgaaa aagattaact                                                   20


<210> 9331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 9331
agcaaaatct tcttaaccaa                                                   20


<210> 9332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9332
gtttttattt cctcaatcat                                                   20


<210> 9333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 9333
agtttactaa cttttctaat                                                   20


<210> 9334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 9334
cagcttagtt ggaaatctct                                                   20


<210> 9335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9335
tcatgctgtt atggttttta                                                   20


<210> 9336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 9336
tactcaagag gctgaggcag                                                   20


<210> 9337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 9337
gtaaattaca taatcaggat                                                   20


<210> 9338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 9338
aaattagtaa attacataat                                                   20


<210> 9339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 9339
tatgaacatg acatgactct                                                   20


<210> 9340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9340
aaattaaatg aagtatgaaa                                                   20


<210> 9341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9341
ttggtctaca agagctgggc                                                   20


<210> 9342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9342
agcatgggct tgtcagaatg                                                   20


<210> 9343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9343
actgagaagc atgggcttgt                                                   20


<210> 9344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 9344
atttgttgat ggattgaaca                                                   20


<210> 9345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 9345
agagctgaag ggatttgttg                                                   20


<210> 9346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 9346
tattttgaag ttagagctga                                                   20


<210> 9347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 9347
tatagtgagg gtgtgacatg                                                   20


<210> 9348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 9348
atggtagagt tttgtatagt                                                   20


<210> 9349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 9349
gggagcttag actagtatgg                                                   20


<210> 9350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 9350
gcagaagctg gaagatttct                                                   20


<210> 9351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GCGAAT

<400> 9351
gcaatcttaa gagtggaagg                                                   20


<210> 9352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 9352
atctcacaat gtgcaatctt                                                   20


<210> 9353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 9353
agacatttga agaacattat                                                   20


<210> 9354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9354
ggctgaggca cgagaattac                                                   20


<210> 9355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 9355
tacttgtgag gctgaggcac                                                   20


<210> 9356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 9356
gtgggcgatc acttgaggcc                                                   20


<210> 9357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 9357
ttaaaagtta aggtcagagg                                                   20


<210> 9358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 9358
agaataatga aagatgggaa                                                   20


<210> 9359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 9359
ccaagaggcc aaaatagatg                                                   20


<210> 9360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 9360
gaaggcacat gccccaaggt                                                   20


<210> 9361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 9361
tggagggaaa gtattttagg                                                   20


<210> 9362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9362
agcacataaa tatgctatca                                                   20


<210> 9363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 9363
atatggaaaa gaggaatacc                                                   20


<210> 9364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 9364
ggagaaggta tatggaaaag                                                   20


<210> 9365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 9365
gcagagactt catacagtct                                                   20


<210> 9366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 9366
tactgaggga gcatatatct                                                   20


<210> 9367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 9367
acatcaatga aaatactttt                                                   20


<210> 9368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 9368
atgatcatga cttaaaattc                                                   20


<210> 9369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9369
agattttccc tattcatttt                                                   20


<210> 9370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9370
tgtccatgtt acagagattt                                                   20


<210> 9371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 9371
cagcaaacta caaagagtgc                                                   20


<210> 9372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 9372
aaagacatca gcaaactaca                                                   20


<210> 9373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 9373
actggtttct tataacattc                                                   20


<210> 9374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 9374
ttctactttt cttattcttc                                                   20


<210> 9375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 9375
ccacatcaca gcgatgctaa                                                   20


<210> 9376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGAT

<400> 9376
agatatctca tctgtaaaat                                                   20


<210> 9377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 9377
tctaggtaaa aatacaagcc                                                   20


<210> 9378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 9378
tactacttct ggaatttgtc                                                   20


<210> 9379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 9379
gctgaatttc ttactacttc                                                   20


<210> 9380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 9380
cctgtatgct ttctgatatg                                                   20


<210> 9381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 9381
atgtgagaat ccttggcctc                                                   20


<210> 9382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 9382
ttgcatgcac actaaaatgt                                                   20


<210> 9383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 9383
gatagggccc aagcccttaa                                                   20


<210> 9384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 9384
ctttacctct aacctcactc                                                   20


<210> 9385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 9385
ttcctctctc tatttcttta                                                   20


<210> 9386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 9386
cttttatttg tcttagagtt                                                   20


<210> 9387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 9387
ctttggtctt ttatttgtct                                                   20


<210> 9388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 9388
ctggtccttt taatcaaaaa                                                   20


<210> 9389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 9389
accagaatac aagttaatga                                                   20


<210> 9390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9390
tcccagatca atggaaccac                                                   20


<210> 9391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 9391
gtcactagag ctctctaagc                                                   20


<210> 9392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 9392
gcattcctta attagtgttc                                                   20


<210> 9393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9393
aagaagcaga ggctgaacct                                                   20


<210> 9394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 9394
attaaaccgg tcaagctcct                                                   20


<210> 9395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 9395
atgaactacc tggtggggtg                                                   20


<210> 9396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 9396
actctaaatg aactacctgg                                                   20


<210> 9397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9397
ataaggctta aatatcatat                                                   20


<210> 9398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 9398
cttttttcat aatactttgc                                                   20


<210> 9399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 9399
taataaagtt tattatttta                                                   20


<210> 9400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 9400
cacttgtatt atattgcaaa                                                   20


<210> 9401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 9401
actaaaatgt tatatacaaa                                                   20


<210> 9402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 9402
attttcttcg atctttgttt                                                   20


<210> 9403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9403
cttatatgat cataatgaca                                                   20


<210> 9404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 9404
tcatggttac tcataaagct                                                   20


<210> 9405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 9405
acaatatttg ggaaatttga                                                   20


<210> 9406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 9406
tcacatgtca tttagcaaat                                                   20


<210> 9407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 9407
ataaagttgt aacttaataa                                                   20


<210> 9408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 9408
ttaatacaaa ttcatagatt                                                   20


<210> 9409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9409
aatttaatgt ggtacccatc                                                   20


<210> 9410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 9410
taggtgataa taatagcatt                                                   20


<210> 9411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 9411
tctaggccaa catagattgg                                                   20


<210> 9412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 9412
atcaaactcc tggacctggt                                                   20


<210> 9413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 9413
tcagtttaaa taacatgttt                                                   20


<210> 9414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9414
tttaaattaa actaatttag                                                   20


<210> 9415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9415
aagcctattc tatagtttta                                                   20


<210> 9416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 9416
agtttatcca acatcgtttc                                                   20


<210> 9417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 9417
agtcttctaa atatggtact                                                   20


<210> 9418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 9418
tcacgtgcag ccgagaggtc                                                   20


<210> 9419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9419
agggcctggt cttaacttca                                                   20


<210> 9420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGGT

<400> 9420
aatattgtgt ctaatagcag                                                   20


<210> 9421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9421
aaagtcagaa ttctgcaaat                                                   20


<210> 9422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9422
ttcatgaatt tagctaaagt                                                   20


<210> 9423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9423
tgatgtttga agatgctttc                                                   20


<210> 9424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 9424
gatacactat ataaaatcac                                                   20


<210> 9425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 9425
atgtaaaatt ctgtgccaag                                                   20


<210> 9426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9426
tgtcccattg aacaataata                                                   20


<210> 9427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9427
caagaaaaca ttgaatgtct                                                   20


<210> 9428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9428
aatgcattcc caagaaaaca                                                   20


<210> 9429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9429
agtatggaaa tagttactgt                                                   20


<210> 9430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 9430
gcaagtatag atttcaaagg                                                   20


<210> 9431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 9431
aatatggtga tgcctactgt                                                   20


<210> 9432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 9432
gaaaactaaa caacagatga                                                   20


<210> 9433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 9433
acttctgatt cctaatacta                                                   20


<210> 9434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 9434
atattattca ataaaaaggc                                                   20


<210> 9435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 9435
ctattataca tttaaaatgt                                                   20


<210> 9436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9436
tctcgattac ctcaaggggg                                                   20


<210> 9437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGGT

<400> 9437
ctctctctcg attacctcaa                                                   20


<210> 9438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 9438
tttcacagct atagtgttgt                                                   20


<210> 9439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 9439
cataagttta caatcaagat                                                   20


<210> 9440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9440
caatcaaagg gaaaaccatg                                                   20


<210> 9441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 9441
ctctttgagt aaggtttttg                                                   20


<210> 9442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 9442
ttcagcatca atcattctct                                                   20


<210> 9443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9443
attctaggct ctgctcctta                                                   20


<210> 9444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 9444
caactttctt actgtctttt                                                   20


<210> 9445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 9445
ctacacaatt aaattaaaag                                                   20


<210> 9446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 9446
tatgtgtgga tttcttctca                                                   20


<210> 9447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 9447
atgccacata gtaactatgt                                                   20


<210> 9448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 9448
atttttgttc tacaccagaa                                                   20


<210> 9449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 9449
gaaggaaaaa aataaaggcc                                                   20


<210> 9450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 9450
caattttaaa aactctataa                                                   20


<210> 9451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9451
ttgaggcatt accttttaaa                                                   20


<210> 9452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 9452
ttccactgat caataatatc                                                   20


<210> 9453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 9453
gacaacagaa gaaaatacag                                                   20


<210> 9454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9454
ccataattag aatgtgagcc                                                   20


<210> 9455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9455
aagttttagt tgcccataat                                                   20


<210> 9456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 9456
atggaactgt gtgtttcacg                                                   20


<210> 9457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9457
tgacctcatt atttcaccaa                                                   20


<210> 9458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 9458
gtgaaatcac tggttttatt                                                   20


<210> 9459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 9459
tcacgtaagt tttcatgtta                                                   20


<210> 9460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9460
acagagcaca gagagagccc                                                   20


<210> 9461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 9461
atagataata tttacgaagc                                                   20


<210> 9462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 9462
tttccttgcc ctccttcatt                                                   20


<210> 9463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 9463
tagcaaaagc tgcctacata                                                   20


<210> 9464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9464
aaaaaactga atattcagtt                                                   20


<210> 9465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 9465
tcatcctctt aagaaaaaaa                                                   20


<210> 9466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9466
aaaagatgag gtacatgtta                                                   20


<210> 9467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9467
aacatatgca tatatatgtt                                                   20


<210> 9468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 9468
tcttcaacta gagcctaaat                                                   20


<210> 9469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 9469
ctattttatt ccagaatatg                                                   20


<210> 9470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9470
catagaaaac tattttattc                                                   20


<210> 9471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGAT

<400> 9471
ttttctattt caaatttggt                                                   20


<210> 9472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9472
tttataatct agttcatatt                                                   20


<210> 9473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9473
gggcaggaat ctctgccaat                                                   20


<210> 9474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 9474
aatagttcta ggatgggggc                                                   20


<210> 9475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 9475
tgactgaact ttaatagttc                                                   20


<210> 9476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9476
tttaatttta gcatactttg                                                   20


<210> 9477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9477
gattaatatg tattgcctta                                                   20


<210> 9478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9478
aagtaatatt actcattgat                                                   20


<210> 9479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9479
ttgataggcc ttgcctatga                                                   20


<210> 9480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9480
aaagttgata ggccttgcct                                                   20


<210> 9481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9481
ccctgcttct agtataaact                                                   20


<210> 9482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 9482
ttagtacaca tctagaaagt                                                   20


<210> 9483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 9483
ataattctgg ttatgtattt                                                   20


<210> 9484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9484
ttgattataa aagtaaaatg                                                   20


<210> 9485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9485
gcatgatctg tagattttta                                                   20


<210> 9486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 9486
aatatcaaac tggatcagtc                                                   20


<210> 9487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 9487
ctcacagggg taatatcaaa                                                   20


<210> 9488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGGT

<400> 9488
gtacctaacc ttcttctcac                                                   20


<210> 9489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 9489
ttcaaatata ttgcttaacg                                                   20


<210> 9490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9490
tgattgtttt taagtctctg                                                   20


<210> 9491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9491
tcaattttta aatagtagag                                                   20


<210> 9492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 9492
taaattcaat ttttaaatag                                                   20


<210> 9493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9493
tgcttgcatt taaggaaaaa                                                   20


<210> 9494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 9494
gccacctcac cccctatact                                                   20


<210> 9495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9495
caatcaagaa atgctaattt                                                   20


<210> 9496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 9496
gaaaaatctt tccatcttca                                                   20


<210> 9497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9497
tttttttcag gttgtttcca                                                   20


<210> 9498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9498
tttttaaaag cactcttctg                                                   20


<210> 9499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 9499
catttgactt tgaaagattt                                                   20


<210> 9500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 9500
actagtccat tgaggatgca                                                   20


<210> 9501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 9501
ggacactaaa ctagtccatt                                                   20


<210> 9502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 9502
cttcatgtac ttcaaaggta                                                   20


<210> 9503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 9503
tttttggccc cctataaata                                                   20


<210> 9504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 9504
gcccagaatt ataataggca                                                   20


<210> 9505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9505
attttctatg actctctgcc                                                   20


<210> 9506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9506
tagaaaatat atatgaaaat                                                   20


<210> 9507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9507
caaaagttaa tttttactta                                                   20


<210> 9508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 9508
tgcagttact aggcataatt                                                   20


<210> 9509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 9509
tgaaaatgtc aaaagaattg                                                   20


<210> 9510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9510
ttcctttatg aaaatgtcaa                                                   20


<210> 9511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 9511
attgctaccc tgaataaaat                                                   20


<210> 9512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 9512
tatctgggca tattgctacc                                                   20


<210> 9513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 9513
acttaactac attggcataa                                                   20


<210> 9514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 9514
tttgttattt ttggctattt                                                   20


<210> 9515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 9515
cctattttac ttaagggtac                                                   20


<210> 9516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 9516
tgaataaacc tattttactt                                                   20


<210> 9517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9517
catgttaaga tcttaactat                                                   20


<210> 9518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 9518
taaggctata ttaggggcta                                                   20


<210> 9519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9519
tctcaggaca atgtattaag                                                   20


<210> 9520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9520
agtaaaactg attttacttc                                                   20


<210> 9521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 9521
ttgtacattt gctgattcat                                                   20


<210> 9522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 9522
acctctgtaa tggtgtaatt                                                   20


<210> 9523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 9523
tgccatagaa aggcaagaaa                                                   20


<210> 9524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGGT

<400> 9524
ggttagtcat ggacgtatct                                                   20


<210> 9525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ACGGAT

<400> 9525
aagaaagcac gcacacacac                                                   20


<210> 9526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 9526
ggatcaaaca catttgagag                                                   20


<210> 9527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GCGGAT

<400> 9527
acagacagca gctgagaaca                                                   20


<210> 9528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 9528
atgagcagct tgctggaaag                                                   20


<210> 9529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 9529
ccaacacttt tggcagctgg                                                   20


<210> 9530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 9530
tgccacgata aggcccaaag                                                   20


<210> 9531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 9531
cctttacctt tccaggggag                                                   20


<210> 9532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 9532
tttcttctcc acaccattca                                                   20


<210> 9533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 9533
gtagttccaa aacaaagcaa                                                   20


<210> 9534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 9534
ctgatgctgt gacaaccctc                                                   20


<210> 9535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGGT

<400> 9535
cattaatcac gggattgtgt                                                   20


<210> 9536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CGGGAT

<400> 9536
atgctaactt tcattaatca                                                   20


<210> 9537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 9537
agtcagagtt gtagataggt                                                   20


<210> 9538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 9538
cttaaggaaa gaagaaaagt                                                   20


<210> 9539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 9539
ttgaggaggt aggggaaata                                                   20


<210> 9540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9540
agatggttat tgatacaatt                                                   20


<210> 9541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9541
ttacaattca acccacaaca                                                   20


<210> 9542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 9542
ggacttcaac ataacttttg                                                   20


<210> 9543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 9543
aagatcacac tcaaacatgc                                                   20


<210> 9544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 9544
ttataaggac cccagttata                                                   20


<210> 9545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 9545
ataagattgt gagctgatcc                                                   20


<210> 9546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 9546
aaagttaaaa tataagggct                                                   20


<210> 9547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CGGGAT

<400> 9547
cagctgcaac aatttaatat                                                   20


<210> 9548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9548
tatgctctaa gcactgtgct                                                   20


<210> 9549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 9549
actgaactga tggctcttct                                                   20


<210> 9550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9550
atactctttt cactgtttct                                                   20


<210> 9551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 9551
gttatctcaa aggtacccat                                                   20


<210> 9552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9552
tctgaagaga tagtcagtgt                                                   20


<210> 9553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 9553
atcagaaaat aaccaaagag                                                   20


<210> 9554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9554
agacagttaa aaatacactc                                                   20


<210> 9555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 9555
gtttctcaac agagtttatg                                                   20


<210> 9556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 9556
ctagcatcct ggtttctcaa                                                   20


<210> 9557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 9557
attttcttta ttcaggggct                                                   20


<210> 9558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 9558
caacttaatc cctagcttac                                                   20


<210> 9559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 9559
aatggtaaat gttcaaagct                                                   20


<210> 9560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 9560
ctattgaatc gttggatgac                                                   20


<210> 9561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 9561
tctggtgttc tattgaatcg                                                   20


<210> 9562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9562
gaataagttc tggtgttcta                                                   20


<210> 9563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9563
caaagctaca gtgagataga                                                   20


<210> 9564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 9564
tagtagaata gtggttatcg                                                   20


<210> 9565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9565
gttgtcatag aagtagatag                                                   20


<210> 9566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 9566
tcacacatat gtggaatcta                                                   20


<210> 9567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 9567
tcaaatatct cacacatatg                                                   20


<210> 9568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9568
atcctgttat ttgtggcaac                                                   20


<210> 9569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9569
ttgaagagat acagtaaaca                                                   20


<210> 9570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9570
gttctttaaa aaattaaaaa                                                   20


<210> 9571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGGT

<400> 9571
accattatgg aaagtaatat                                                   20


<210> 9572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 9572
aatccttaca cactgattgt                                                   20


<210> 9573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 9573
tttaaaggat atggagaaaa                                                   20


<210> 9574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 9574
tcaaaagata taagtgttta                                                   20


<210> 9575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 9575
ttcaaaaatg gacaaaagac                                                   20


<210> 9576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 9576
tgtaaactat gcatctgata                                                   20


<210> 9577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9577
tagagtgaag agataaccta                                                   20


<210> 9578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 9578
acagcaaggc aaacaatcaa                                                   20


<210> 9579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 9579
caaaagcaaa tatagacaaa                                                   20


<210> 9580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 9580
tgttctaggc aaggattttt                                                   20


<210> 9581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 9581
ttcatgatgt tgttctaggc                                                   20


<210> 9582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9582
aactgaatag ccacatgcaa                                                   20


<210> 9583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 9583
agtaaatggt tctgggcaaa                                                   20


<210> 9584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 9584
atctacacat atacagtcaa                                                   20


<210> 9585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9585
agacacacag agcaatacat                                                   20


<210> 9586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9586
ataaagctat agtaaccaaa                                                   20


<210> 9587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9587
gatattccat gttcatggat                                                   20


<210> 9588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 9588
gggaaagata ttccatgttc                                                   20


<210> 9589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9589
aaaagtagta gatttcataa                                                   20


<210> 9590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 9590
atgatctgat cttagatata                                                   20


<210> 9591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 9591
tccaagatct ggaacaagat                                                   20


<210> 9592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9592
aactttctat attatatcaa                                                   20


<210> 9593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 9593
gctcaactgg aaatcgtccc                                                   20


<210> 9594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 9594
tccaaaaaaa tcaaaaggaa                                                   20


<210> 9595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9595
aggaccacat ggcttcactg                                                   20


<210> 9596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9596
accaataatg agtaacaaga                                                   20


<210> 9597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 9597
aaaactcaaa cagaccaata                                                   20


<210> 9598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9598
cctaaatttg gatgcaactt                                                   20


<210> 9599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 9599
tttgaattgt ttgcctaaat                                                   20


<210> 9600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9600
cctgttctgg atcatatcct                                                   20


<210> 9601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 9601
ctttattaca aatgcctgtt                                                   20


<210> 9602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9602
cgtgatgaag atcagtgctt                                                   20


<210> 9603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9603
aagtagctat tggttacaga                                                   20


<210> 9604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 9604
caattattat aagtatggaa                                                   20


<210> 9605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 9605
atgtacaatt attataagta                                                   20


<210> 9606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9606
aagaatgcca ctttttaaga                                                   20


<210> 9607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9607
cactaccttg ggatatagtt                                                   20


<210> 9608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 9608
ttaagtctta gccactacct                                                   20


<210> 9609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9609
ggatgagcca aagaggcaaa                                                   20


<210> 9610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 9610
tggttgtgtt tgtgatgagc                                                   20


<210> 9611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 9611
agttcccaga gtcttgaact                                                   20


<210> 9612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 9612
tcatctccca cttgagttcc                                                   20


<210> 9613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 9613
tcataatctt catctcccac                                                   20


<210> 9614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9614
acaaacctac ctgaaaatat                                                   20


<210> 9615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9615
taagtcatgt agcatagtgt                                                   20


<210> 9616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 9616
gtatgcacaa ttaaatatac                                                   20


<210> 9617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 9617
tggttatatc tatatgataa                                                   20


<210> 9618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 9618
gaaatctagt gccctataaa                                                   20


<210> 9619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9619
ggtataaagc catgcagcta                                                   20


<210> 9620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 9620
acttaataat ttgtctcccc                                                   20


<210> 9621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 9621
gcttgtgact tatagctcaa                                                   20


<210> 9622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 9622
tataaaggca gagccatgtc                                                   20


<210> 9623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 9623
cagttataaa tctagagtta                                                   20


<210> 9624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 9624
gagttataca gttataaatc                                                   20


<210> 9625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 9625
tttattcaca gttataaagc                                                   20


<210> 9626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 9626
aaattcttat tcttagtatg                                                   20


<210> 9627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 9627
aagtcaatgg ctgacctttc                                                   20


<210> 9628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 9628
attatttctt aacatttatg                                                   20


<210> 9629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 9629
agttgctctc agaataaaac                                                   20


<210> 9630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9630
gcctggcaga cagttgctct                                                   20


<210> 9631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 9631
actctacaga tgtgggaccc                                                   20


<210> 9632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GCGAGT

<400> 9632
tcatccctcg atatctatgg                                                   20


<210> 9633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 9633
ttttccaaga cggtaaagta                                                   20


<210> 9634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 9634
aatgctctat atttaattga                                                   20


<210> 9635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 9635
ataaaatgct ctatatttaa                                                   20


<210> 9636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 9636
ctgcactcca gcttggacta                                                   20


<210> 9637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 9637
tgctcaggag gctgaggcat                                                   20


<210> 9638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 9638
acttggaaaa cgagattata                                                   20


<210> 9639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9639
ttactaagac tccaccctcc                                                   20


<210> 9640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 9640
ctagtgagtc aaggtatgta                                                   20


<210> 9641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 9641
cccttacctg catatttcta                                                   20


<210> 9642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 9642
aaacaatttt atacttcttc                                                   20


<210> 9643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 9643
ccctcctaat ttctccccaa                                                   20


<210> 9644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9644
cgcagttggg tcagggttaa                                                   20


<210> 9645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 9645
tacttaaatc gcagttgggt                                                   20


<210> 9646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 9646
tgttaatact taaatcgcag                                                   20


<210> 9647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 9647
aacactctcc acactttgct                                                   20


<210> 9648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TCGAAT

<400> 9648
gcctggccat ccccaaagtc                                                   20


<210> 9649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 9649
tccccagttg ctgagattac                                                   20


<210> 9650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 9650
gatcctcctg cctccacctc                                                   20


<210> 9651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 9651
tctcactctg ttgcccagtc                                                   20


<210> 9652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 9652
tttgcctaaa ccatttcaag                                                   20


<210> 9653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9653
tctccctcca cagtgcctgt                                                   20


<210> 9654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 9654
tcttaacatt gcatgtagtg                                                   20


<210> 9655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9655
atattaacaa ttagtatgaa                                                   20


<210> 9656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9656
agtgaataca gcaaagtggt                                                   20


<210> 9657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 9657
acttagcagt gattcggata                                                   20


<210> 9658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TCGGAT

<400> 9658
ctgaggaact tagcagtgat                                                   20


<210> 9659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9659
gggaatccga tttggaaaat                                                   20


<210> 9660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 9660
gacagtgcca attgcacctg                                                   20


<210> 9661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 9661
agataagaca agcagaagat                                                   20


<210> 9662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 9662
ttatgtgaaa caaaccttac                                                   20


<210> 9663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 9663
gcagtgacta gaattaaaaa                                                   20


<210> 9664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9664
aacctccaga ttgcagtgac                                                   20


<210> 9665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 9665
agtctaggga tacagtgatg                                                   20


<210> 9666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 9666
gagtctgcag gggctagtct                                                   20


<210> 9667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 9667
gtatggctga ccctctgctg                                                   20


<210> 9668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 9668
gctccccatg gtaattcttc                                                   20


<210> 9669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 9669
atgatgtaat gataatggtg                                                   20


<210> 9670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 9670
atgaatgcta ggagagtttt                                                   20


<210> 9671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 9671
taatgataga tgaatgctag                                                   20


<210> 9672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9672
gtaataaaga gtaatgatag                                                   20


<210> 9673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 9673
cctgtttctc acaggtaata                                                   20


<210> 9674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9674
attctagcac gcttcttgga                                                   20


<210> 9675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 9675
tcataatgcc attattgcat                                                   20


<210> 9676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 9676
gaaataaaac tttgcttcaa                                                   20


<210> 9677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 9677
catttttttt ttttacaatg                                                   20


<210> 9678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 9678
tcaatttcct tttttgtttc                                                   20


<210> 9679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 9679
aggtatgacc aaaatgaggg                                                   20


<210> 9680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 9680
ttttaggtat gaccaaaatg                                                   20


<210> 9681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9681
attcccagac ctccgacctc                                                   20


<210> 9682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 9682
gacaactatt aaaccatttc                                                   20


<210> 9683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9683
ccattaatca aaatgagact                                                   20


<210> 9684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TCGGGT

<400> 9684
aaaaataagt tttagtcagc                                                   20


<210> 9685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 9685
cctgatatag ccttccacat                                                   20


<210> 9686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9686
tggaggaact accaatatca                                                   20


<210> 9687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9687
tggtgagtgt ttcattcgtg                                                   20


<210> 9688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 9688
aaaacagagg ggatatattg                                                   20


<210> 9689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGAT

<400> 9689
gatttatagt aaaaaacaga                                                   20


<210> 9690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 9690
ttgatcatgg acactggtgt                                                   20


<210> 9691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 9691
ttgaagtggg cctttgaaca                                                   20


<210> 9692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 9692
atgcttctga cacttaaaga                                                   20


<210> 9693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 9693
tatcagacaa ggaagaagtg                                                   20


<210> 9694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 9694
ggcattgttt aggtattatt                                                   20


<210> 9695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9695
tccgtcgcct cccaaagtgc                                                   20


<210> 9696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 9696
aattcttctg cctcagcctc                                                   20


<210> 9697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 9697
tctcgctttg ttgcccaggc                                                   20


<210> 9698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 9698
tatttttttt ttttttgaga                                                   20


<210> 9699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 9699
gtatttataa gctcctatag                                                   20


<210> 9700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 9700
cttacaaatt ccttccaata                                                   20


<210> 9701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 9701
ctgcacaaaa aatatacatc                                                   20


<210> 9702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 9702
ccttgtaacc accataaaaa                                                   20


<210> 9703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 9703
gtaagtgcct tcacttccca                                                   20


<210> 9704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 9704
ctcatcaggt atccagaagg                                                   20


<210> 9705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 9705
gcttacaagc aggagaaaat                                                   20


<210> 9706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9706
catagcaatc tgcctacttt                                                   20


<210> 9707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 9707
tttacattac agtggcagag                                                   20


<210> 9708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 9708
cataaacttt attcaaacat                                                   20


<210> 9709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9709
gtggttaaaa taatcaaaag                                                   20


<210> 9710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9710
attgtgtggc cctgggagct                                                   20


<210> 9711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 9711
gtaagactag cctctatagc                                                   20


<210> 9712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9712
tctacaatta ttaattgcaa                                                   20


<210> 9713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 9713
ttccgcgtgc tgtgtggaga                                                   20


<210> 9714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 9714
tgtgttccgc gtgctgtgtg                                                   20


<210> 9715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9715
gctctttggt aagagctaca                                                   20


<210> 9716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CCGAGT

<400> 9716
ctttatattt gcttttagct                                                   20


<210> 9717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 9717
gaaaaataag aatattttag                                                   20


<210> 9718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9718
aattgatgaa aatgaaaaat                                                   20


<210> 9719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 9719
aagtattaga aagtagaatt                                                   20


<210> 9720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9720
tgtatgaaag tattagaaag                                                   20


<210> 9721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9721
gattatatgt tcataacttt                                                   20


<210> 9722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9722
agtaagaagc ttgtggctta                                                   20


<210> 9723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 9723
tatagtacaa taatttattt                                                   20


<210> 9724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9724
acttaaagaa ctaaaaccac                                                   20


<210> 9725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9725
ttttaaaaac ttttgggaat                                                   20


<210> 9726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 9726
cattattttt aaaaactttt                                                   20


<210> 9727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGGT

<400> 9727
gccattatat tctataataa                                                   20


<210> 9728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 9728
gctctttcta gcagatgtgg                                                   20


<210> 9729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 9729
atgagtattt ccaagtaggc                                                   20


<210> 9730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 9730
actgattgcc atggatccat                                                   20


<210> 9731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 9731
tggtattaaa actgattgcc                                                   20


<210> 9732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 9732
tttctcactt aggtctttac                                                   20


<210> 9733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9733
tttacaggac taagttagat                                                   20


<210> 9734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 9734
tgctgataaa tctttaaaga                                                   20


<210> 9735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 9735
cttctgctga taaatcttta                                                   20


<210> 9736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9736
agtcctttga taccagtatc                                                   20


<210> 9737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 9737
tttcggtgtt gcctttttaa                                                   20


<210> 9738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 9738
cttgagtcaa agtgtaccca                                                   20


<210> 9739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 9739
atcttctttg gtcagattcc                                                   20


<210> 9740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9740
atagacctaa acatttccct                                                   20


<210> 9741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 9741
tgcatccctg tgaactcaga                                                   20


<210> 9742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CCGGAT

<400> 9742
ttctaattgt tggtggagat                                                   20


<210> 9743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 9743
atttatcttt ggaaaaaggc                                                   20


<210> 9744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 9744
tgtttttccc catgtgctcg                                                   20


<210> 9745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 9745
tgaagaccag aagttctttt                                                   20


<210> 9746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 9746
ttcataaacc atgaataact                                                   20


<210> 9747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9747
cttatgactc ttcataaacc                                                   20


<210> 9748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 9748
ccagttcatt tttagggcca                                                   20


<210> 9749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 9749
caaaatgcca gtttttgact                                                   20


<210> 9750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 9750
cagtgctggt cacactaact                                                   20


<210> 9751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 9751
ccaattagta aaattgatgc                                                   20


<210> 9752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 9752
gaactggaca tagaagactc                                                   20


<210> 9753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 9753
ttcatttatc atattcttgg                                                   20


<210> 9754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 9754
gaatgctgat tctgcattat                                                   20


<210> 9755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9755
agagtcccaa agtcctgggt                                                   20


<210> 9756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 9756
gtcctcagag tcccaaagtc                                                   20


<210> 9757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 9757
tagtgaagtg tttgggtcct                                                   20


<210> 9758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 9758
acataatagt agtgaagtgt                                                   20


<210> 9759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 9759
cacatatttt cagaaaacct                                                   20


<210> 9760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 9760
ctataaaagg ttaccatctt                                                   20


<210> 9761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 9761
tttccatatg aatggatgtg                                                   20


<210> 9762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 9762
atccagaact ttccatatga                                                   20


<210> 9763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9763
gcatatccag aactttccat                                                   20


<210> 9764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9764
gtcagatgaa tctgcagcct                                                   20


<210> 9765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9765
tttcatattt tttatgtcag                                                   20


<210> 9766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 9766
ggaacaccac ccaatgactg                                                   20


<210> 9767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 9767
agtgtatcta ttttattgta                                                   20


<210> 9768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 9768
atctggaatt gctctccata                                                   20


<210> 9769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 9769
ttgcacacaa attcttgatc                                                   20


<210> 9770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 9770
cttttttctc ccagaacttg                                                   20


<210> 9771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 9771
tgactgattt gtatctggtt                                                   20


<210> 9772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9772
tataaacctt gtttcaatat                                                   20


<210> 9773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9773
cagcaagagt tttttctgga                                                   20


<210> 9774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 9774
cacctgtgaa ctattacagc                                                   20


<210> 9775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 9775
tatttctagt tgcttggttc                                                   20


<210> 9776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 9776
tggtgtgaaa tgtctatttc                                                   20


<210> 9777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 9777
ccccaggtcc cacctggtcc                                                   20


<210> 9778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 9778
ctaataagca aagatagtca                                                   20


<210> 9779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 9779
aaaacccaca aagacagatg                                                   20


<210> 9780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 9780
ttgtttttat gtgcttaaaa                                                   20


<210> 9781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 9781
agataaccaa tggatactga                                                   20


<210> 9782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 9782
aatgatggta aagataacca                                                   20


<210> 9783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9783
aggcacatga aattcttagg                                                   20


<210> 9784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 9784
ccaacctcag acagagagca                                                   20


<210> 9785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 9785
atctcctttc agaggatatg                                                   20


<210> 9786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 9786
gtagttccta tctcctttca                                                   20


<210> 9787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 9787
atcttatacc tacaatttat                                                   20


<210> 9788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9788
ttaattcctt taatcctcac                                                   20


<210> 9789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 9789
actgtcacat gacaaactat                                                   20


<210> 9790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 9790
gtaattccag aaatttatca                                                   20


<210> 9791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 9791
cactaattgt tcctttcaaa                                                   20


<210> 9792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 9792
aataaataca cttgttatgc                                                   20


<210> 9793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9793
accaacatag tgttttaaat                                                   20


<210> 9794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 9794
gtttgtgtat atatgtgtgt                                                   20


<210> 9795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 9795
gcagacaaac atgatagatc                                                   20


<210> 9796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 9796
tttttacaga gatctctcaa                                                   20


<210> 9797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 9797
ctacaaaact agaggaatta                                                   20


<210> 9798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 9798
agtgaaaact acaaaactag                                                   20


<210> 9799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 9799
ttaatgaagt ttcttcattt                                                   20


<210> 9800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 9800
atgagcatgt taaatttctg                                                   20


<210> 9801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9801
ctgcaaggta tttttcatta                                                   20


<210> 9802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9802
ggccacacat atatttcaat                                                   20


<210> 9803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 9803
gacaatgtag tatttcaagt                                                   20


<210> 9804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 9804
tttctcattc ctggagtttc                                                   20


<210> 9805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 9805
agtgagatct ttctcattcc                                                   20


<210> 9806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ACGAGT

<400> 9806
tacagcagtt ccaaaggtct                                                   20


<210> 9807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9807
aaatatttca tctggagtct                                                   20


<210> 9808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 9808
tttttaaaaa atatttcatc                                                   20


<210> 9809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9809
cttcttatct tgaaaaaatt                                                   20


<210> 9810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 9810
cctattccaa ggaatcttat                                                   20


<210> 9811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 9811
cttaatatgt acctattcca                                                   20


<210> 9812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 9812
tcccatttct atgaagaaat                                                   20


<210> 9813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 9813
gatatcagta cagaaaatgc                                                   20


<210> 9814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ACGGAT

<400> 9814
tctttagaga acaatttatg                                                   20


<210> 9815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 9815
gaagggcctt ctctggtctt                                                   20


<210> 9816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 9816
aagagatata ggatctgaga                                                   20


<210> 9817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 9817
caaaggcaga ggaagagata                                                   20


<210> 9818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 9818
agccacctgc cctcaggcca                                                   20


<210> 9819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 9819
tggaagaagt tttcttctca                                                   20


<210> 9820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9820
atttacctgg tcctgaaagg                                                   20


<210> 9821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 9821
aataatttac ctggtcctga                                                   20


<210> 9822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9822
atggagcagt aactctaggc                                                   20


<210> 9823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9823
agcaaaatga atggcattaa                                                   20


<210> 9824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9824
tataagttct gtgcagcaaa                                                   20


<210> 9825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9825
ggggattgat atataaaaag                                                   20


<210> 9826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGAT

<400> 9826
ccaatttttt tgtgaagcct                                                   20


<210> 9827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 9827
ctgagctctt agtatgtaag                                                   20


<210> 9828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9828
atgagtcata taagcatgaa                                                   20


<210> 9829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9829
tggacatgag tcatataagc                                                   20


<210> 9830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 9830
aaaggattta caccctggac                                                   20


<210> 9831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 9831
tattgaacta gatccttcca                                                   20


<210> 9832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 9832
atatacacag taaaaaaaga                                                   20


<210> 9833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9833
taaagagacc attcacacta                                                   20


<210> 9834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9834
tttgaaagac cttatagttt                                                   20


<210> 9835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 9835
agatgtacac aggtttccat                                                   20


<210> 9836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 9836
agagaactcg ggagaggata                                                   20


<210> 9837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 9837
tagggtaaga gaactcggga                                                   20


<210> 9838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 9838
tagagaaaaa tgtcttattt                                                   20


<210> 9839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9839
taaatgtgta tcacccgagg                                                   20


<210> 9840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9840
tgctgagaaa ttgtcgaaat                                                   20


<210> 9841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9841
gaagaaacag aagaaagaaa                                                   20


<210> 9842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 9842
gcagaattat gggcctctca                                                   20


<210> 9843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9843
tatacaagta ttaggagaag                                                   20


<210> 9844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 9844
ggcaattgca gcggcagcgg                                                   20


<210> 9845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 9845
tgtcctgtcc tagggtttcc                                                   20


<210> 9846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 9846
aggtgaaaga tgtcctgtcc                                                   20


<210> 9847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GCGAGT

<400> 9847
tgtcttattg catggtttat                                                   20


<210> 9848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 9848
gcctgattct attgatgata                                                   20


<210> 9849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 9849
actcaatctt tattaaacca                                                   20


<210> 9850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 9850
gttatcccag gtactaccta                                                   20


<210> 9851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 9851
ataaacaaaa cattttgtaa                                                   20


<210> 9852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9852
tttatttccc atgtttttac                                                   20


<210> 9853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9853
aaattataca tacatataaa                                                   20


<210> 9854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 9854
aaaaatcttt tagaataatg                                                   20


<210> 9855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9855
tatcatgagg aaaaatcttt                                                   20


<210> 9856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 9856
cacctagtta aatctcttca                                                   20


<210> 9857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 9857
tcatgttttg ttaatgtcac                                                   20


<210> 9858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 9858
aattaacaga tactcttcta                                                   20


<210> 9859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 9859
atacacacaa tggatttccc                                                   20


<210> 9860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 9860
tatatacaca catacacaca                                                   20


<210> 9861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9861
tatcatgagg aaaaatcttt                                                   20


<210> 9862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9862
gaaccaattc tgggctgagc                                                   20


<210> 9863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9863
ctccagctag attttcttta                                                   20


<210> 9864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9864
agaagctaaa cagaaagaat                                                   20


<210> 9865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9865
cattgaagaa gctaaacaga                                                   20


<210> 9866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9866
tactactaca cttaataatc                                                   20


<210> 9867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 9867
tgagcaaagg atttaatttt                                                   20


<210> 9868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 9868
ctaaaatttg aaagtgagca                                                   20


<210> 9869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 9869
ttttaacagt aaaagggact                                                   20


<210> 9870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9870
gatgataaag aaagaaaaga                                                   20


<210> 9871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9871
taattgaaaa tacctatgag                                                   20


<210> 9872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 9872
ctaatgtagg taacaggttg                                                   20


<210> 9873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 9873
cggtggtggg gggcaaaggg                                                   20


<210> 9874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 9874
aacaacgcat gttctcactc                                                   20


<210> 9875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 9875
ttcatgtcct ttgcagggac                                                   20


<210> 9876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9876
aatactatgc agccataaaa                                                   20


<210> 9877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 9877
aatgtggcac atatacacca                                                   20


<210> 9878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 9878
aaatgcccat caatgataga                                                   20


<210> 9879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 9879
gtgacccagc aatcccatta                                                   20


<210> 9880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 9880
aatgctttta aactgttggt                                                   20


<210> 9881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 9881
tggagaaaat gtggagaaat                                                   20


<210> 9882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9882
agataccatc tcatgccagt                                                   20


<210> 9883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 9883
caggtcttaa aacctagata                                                   20


<210> 9884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGGT

<400> 9884
acacacaccg gggcctgttg                                                   20


<210> 9885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 9885
gcatgttctc actcataagt                                                   20


<210> 9886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 9886
atcatgtcct ttacagggac                                                   20


<210> 9887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9887
atactatgca gccattaaaa                                                   20


<210> 9888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 9888
aatgtggtac atatacacca                                                   20


<210> 9889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 9889
tatttacaat agcaaagaga                                                   20


<210> 9890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ACGAAT

<400> 9890
attactgggt atataccgaa                                                   20


<210> 9891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 9891
ttgacctagc aatcccatta                                                   20


<210> 9892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 9892
agcactttta cactgttggt                                                   20


<210> 9893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9893
agataccatc tcaagtcagt                                                   20


<210> 9894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 9894
atcccatcaa aaagtgggca                                                   20


<210> 9895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 9895
tcattggttc tgtttatgtg                                                   20


<210> 9896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 9896
attgatagtt tttaacatga                                                   20


<210> 9897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9897
gtttattgat agtttttaac                                                   20


<210> 9898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 9898
attcagtatg atattggcta                                                   20


<210> 9899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 9899
gtcttgtgcc agtttttaaa                                                   20


<210> 9900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9900
ccagaaattc caacactata                                                   20


<210> 9901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9901
ttgacttccg gtcttcctat                                                   20


<210> 9902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9902
atgatcgggt tttctaaata                                                   20


<210> 9903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TCGGGT

<400> 9903
gagttttggg gctgagatga                                                   20


<210> 9904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 9904
tgaagttgct tatcagttta                                                   20


<210> 9905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 9905
cttgtctatt gttggtgtat                                                   20


<210> 9906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 9906
tctttatagc aattgcaaat                                                   20


<210> 9907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 9907
ttgtgtcctc tcttgtttcc                                                   20


<210> 9908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 9908
attcttccta tccatgagta                                                   20


<210> 9909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 9909
gacattgatt cttcctatcc                                                   20


<210> 9910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9910
gtaatttgat gggactagca                                                   20


<210> 9911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9911
ccagctttgt tctttttgct                                                   20


<210> 9912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 9912
ccattggcct atatgtctgt                                                   20


<210> 9913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 9913
ccagcaccat ttattatata                                                   20


<210> 9914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 9914
cattaagtct ttaatccatc                                                   20


<210> 9915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 9915
cttctagggt tttcatggtt                                                   20


<210> 9916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 9916
gtgttgccta ggttttcttc                                                   20


<210> 9917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 9917
tctttgccca tgcctatttc                                                   20


<210> 9918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 9918
taatattaga cctttgtcag                                                   20


<210> 9919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 9919
atgcacttta cagcaaaaat                                                   20


<210> 9920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 9920
tatttccgag aatattataa                                                   20


<210> 9921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 9921
tttatattta ctttatttcc                                                   20


<210> 9922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9922
taacaatgat tcacttttct                                                   20


<210> 9923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9923
atgtggctat ttcctctaac                                                   20


<210> 9924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 9924
gactgttttc catgcgtgct                                                   20


<210> 9925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 9925
ttcctgagta tatcatccca                                                   20


<210> 9926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 9926
tctctagatc tctcgccttc                                                   20


<210> 9927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TCGAAT

<400> 9927
actaataata tgggtagttc                                                   20


<210> 9928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 9928
ttactcccat cactaataat                                                   20


<210> 9929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 9929
aggaggtttt ttatttattt                                                   20


<210> 9930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9930
gagaaacatg cattgtattt                                                   20


<210> 9931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 9931
gggaaaacct ttaccaacag                                                   20


<210> 9932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGGT

<400> 9932
cgtgtgtagt cagtgtccag                                                   20


<210> 9933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 9933
gtccccctat agaagaaacc                                                   20


<210> 9934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9934
acagacagac ttatgccttg                                                   20


<210> 9935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 9935
tattaaacac tttctatgtg                                                   20


<210> 9936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9936
tattgactct aatctattcc                                                   20


<210> 9937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9937
tgctgttccc agaagaatct                                                   20


<210> 9938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9938
gataaggttg ctgttcccag                                                   20


<210> 9939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 9939
actggcaaca taggaataaa                                                   20


<210> 9940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 9940
tctgtgtaca ctggcaacat                                                   20


<210> 9941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9941
tttaagaata ttgtatatat                                                   20


<210> 9942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9942
gacttgggta cacatatttt                                                   20


<210> 9943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 9943
agcaaaggga ttccttggac                                                   20


<210> 9944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 9944
gttttggcca ctctaagcaa                                                   20


<210> 9945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 9945
taaatgtgac tcataggtga                                                   20


<210> 9946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 9946
ggtcttcttt ctggaaaacg                                                   20


<210> 9947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 9947
aaaactccac caaaagttgg                                                   20


<210> 9948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TCGAAT

<400> 9948
gcaagacttt gagacagtgc                                                   20


<210> 9949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9949
aaaggctgaa agagaaggaa                                                   20


<210> 9950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 9950
ttgtggtttc agcacagatt                                                   20


<210> 9951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 9951
agaatatttt tattacttgg                                                   20


<210> 9952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9952
ctgttcaaat tcttcttcaa                                                   20


<210> 9953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 9953
catattgcct gggaccaggc                                                   20


<210> 9954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 9954
tatgagaaaa tagtaaataa                                                   20


<210> 9955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 9955
ttatcaataa atatttgagg                                                   20


<210> 9956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9956
cgtcctaatg atgcatttct                                                   20


<210> 9957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 9957
aggtttgtat aagtgcaccc                                                   20


<210> 9958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 9958
tataacagtt gcctacaata                                                   20


<210> 9959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 9959
tccggagtat tgtaccacat                                                   20


<210> 9960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CGGAGT

<400> 9960
cttactgagt ctgcctcttc                                                   20


<210> 9961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 9961
tcacttatgt tactgcctta                                                   20


<210> 9962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 9962
tcctaagtaa gtatggactg                                                   20


<210> 9963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9963
attgtcatct cctcaacacc                                                   20


<210> 9964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9964
tactactaaa aattagcaca                                                   20


<210> 9965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 9965
gccttaacag caaatgacag                                                   20


<210> 9966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 9966
catttaaaca tttactatac                                                   20


<210> 9967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 9967
aggaagtcag gttcttatag                                                   20


<210> 9968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 9968
atcagatttt ttaatttgac                                                   20


<210> 9969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 9969
tagaagcaac attcaaatcc                                                   20


<210> 9970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 9970
gataattcac ttacttaaga                                                   20


<210> 9971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 9971
gagcagctag tacagaatgt                                                   20


<210> 9972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9972
ctgtttttga gcagctagta                                                   20


<210> 9973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 9973
gcccatcctt cccgaggttc                                                   20


<210> 9974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 9974
tccatcctta ttaaaatatt                                                   20


<210> 9975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 9975
tgtgaaccag cattagttta                                                   20


<210> 9976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 9976
tgtaaagttt tctacaaacc                                                   20


<210> 9977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 9977
ctttcagaat catcccactt                                                   20


<210> 9978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9978
gtgattcatt ctttatcttt                                                   20


<210> 9979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 9979
cggggtttca ttgtgttagc                                                   20


<210> 9980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CGGGGT

<400> 9980
ttttgtattt ttagtagaga                                                   20


<210> 9981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CCGGGT

<400> 9981
ctcactgtaa gctccgcctc                                                   20


<210> 9982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 9982
tctcactctg tcgcctaggc                                                   20


<210> 9983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 9983
tttttttttt ttttttgaga                                                   20


<210> 9984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 9984
tatacctagt agtgggatta                                                   20


<210> 9985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 9985
tctcagtata tacctagtag                                                   20


<210> 9986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 9986
attcatcagt tgatggacat                                                   20


<210> 9987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 9987
ctaatctact ttctgtccct                                                   20


<210> 9988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 9988
ctcatttttt aaactatact                                                   20


<210> 9989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 9989
ttttaaaaat aggtttattg                                                   20


<210> 9990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9990
attaatttaa aaacttcacc                                                   20


<210> 9991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 9991
gttgtctttc tgagcaaggg                                                   20


<210> 9992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGAT

<400> 9992
tgcattattt gcccttcgtt                                                   20


<210> 9993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 9993
atcccctgca ctagttttct                                                   20


<210> 9994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 9994
gaactacatt tgccagagtg                                                   20


<210> 9995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 9995
cttgtgagaa ctacatttgc                                                   20


<210> 9996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 9996
tattggcctt cactactaac                                                   20


<210> 9997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 9997
gtggttatat tgggctaaaa                                                   20


<210> 9998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 9998
tatgctgcta cagatgaaag                                                   20


<210> 9999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 9999
tggcaatatt taaaagatca                                                   20


<210> 10000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10000
atgagaaagt gctaaggcaa                                                   20


<210> 10001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 10001
ccatggattt aagctgtaca                                                   20


<210> 10002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 10002
actgatgata atgaatgccc                                                   20


<210> 10003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10003
caggttaggc actgatgata                                                   20


<210> 10004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 10004
ataaccattc acttggttgt                                                   20


<210> 10005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 10005
catgagaaat ttagtgtatt                                                   20


<210> 10006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 10006
aattctacag atgatttgat                                                   20


<210> 10007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 10007
ataagatggg atcattgcct                                                   20


<210> 10008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 10008
tatttcctca aagtataaga                                                   20


<210> 10009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 10009
gcagagttat caaaagatga                                                   20


<210> 10010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 10010
aaagatagaa gagaagactg                                                   20


<210> 10011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 10011
tcaagtcctc gtgaaagtga                                                   20


<210> 10012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10012
taatgaatga gtagttatat                                                   20


<210> 10013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 10013
tgttttgcta gtgataatga                                                   20


<210> 10014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10014
tggatgtttt gctagtgata                                                   20


<210> 10015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 10015
aaaaatatat gggtttttgt                                                   20


<210> 10016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 10016
gctggcattt aaaaaaatat                                                   20


<210> 10017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 10017
aatttggcta taaagggaag                                                   20


<210> 10018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGGT

<400> 10018
ggtaagaata aggtgcatac                                                   20


<210> 10019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 10019
taagtggtag ggttcaaggt                                                   20


<210> 10020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 10020
gagaaaattt gggtaagtgg                                                   20


<210> 10021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 10021
agagaatttc ttgagaaaat                                                   20


<210> 10022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 10022
aagtaacagg gaagtcatca                                                   20


<210> 10023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 10023
atgctgcaag atcaaggagt                                                   20


<210> 10024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 10024
agaatcatgc tgcaagatca                                                   20


<210> 10025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 10025
tagaaacaga tgtgcttgtg                                                   20


<210> 10026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 10026
agatctacaa ctctgacatt                                                   20


<210> 10027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 10027
ctgatatttt taagtagata                                                   20


<210> 10028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 10028
tatagaaatc agagggcctg                                                   20


<210> 10029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 10029
ccaggtggat atataatata                                                   20


<210> 10030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 10030
gatgcctttg agatgtccag                                                   20


<210> 10031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 10031
tttctggctg caataactgg                                                   20


<210> 10032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 10032
tcagtttctg gctgcaataa                                                   20


<210> 10033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 10033
taaagaagac aggaagcatt                                                   20


<210> 10034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 10034
aaagtctgta gagcttgctg                                                   20


<210> 10035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 10035
gagaaaataa aggtttcatc                                                   20


<210> 10036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 10036
agcaagggta gatggtagat                                                   20


<210> 10037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 10037
ttgtgcacaa ctgattgagc                                                   20


<210> 10038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 10038
ggacatttca gcccatggga                                                   20


<210> 10039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGGT

<400> 10039
gagaaagtag cagaaaaaat                                                   20


<210> 10040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 10040
gtggtttggt aagagaaagg                                                   20


<210> 10041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 10041
aaagggaggg tatgggttta                                                   20


<210> 10042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 10042
gtcctgaata aagggagggt                                                   20


<210> 10043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 10043
gcaaaggtcc tgaataaagg                                                   20


<210> 10044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 10044
aaatagcatg ggcaaaggtc                                                   20


<210> 10045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGGT

<400> 10045
tgggtgtgag tctatgtgtg                                                   20


<210> 10046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 10046
aaaatagttt aagtgtgggt                                                   20


<210> 10047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 10047
agccataaaa tagtttaagt                                                   20


<210> 10048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 10048
ataaatgcca tgcaaaggaa                                                   20


<210> 10049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 10049
cacagagctt atcatctagt                                                   20


<210> 10050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 10050
aagaggtgtt taaatcaagt                                                   20


<210> 10051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10051
tgcatgacaa ttagctaata                                                   20


<210> 10052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10052
tctttatatt atatttaaac                                                   20


<210> 10053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 10053
taatagagcc cttgagttat                                                   20


<210> 10054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 10054
taataataat aatagagccc                                                   20


<210> 10055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 10055
tactcaggag gctgaggcag                                                   20


<210> 10056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 10056
taatttaatt catcgctttc                                                   20


<210> 10057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 10057
acaagaatat actaatagat                                                   20


<210> 10058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 10058
ctgagacagc tacttgttac                                                   20


<210> 10059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 10059
agtatttata gacagaaaaa                                                   20


<210> 10060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 10060
ctcaactcag caacatgagc                                                   20


<210> 10061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 10061
cctatttctg agtttatact                                                   20


<210> 10062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 10062
tctgagtctt gctcctattt                                                   20


<210> 10063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 10063
ctgggatctg tccttttatt                                                   20


<210> 10064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 10064
ttaaacttaa gttttctcac                                                   20


<210> 10065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 10065
ctgtaaaatt aatatatctg                                                   20


<210> 10066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 10066
aaacttattt ccaatggatg                                                   20


<210> 10067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 10067
tgatttgaaa cttatttcca                                                   20


<210> 10068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 10068
tttactacca ccatttgatg                                                   20


<210> 10069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 10069
ggaaatgagg gaggaaaggt                                                   20


<210> 10070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 10070
atctatctga tggtgcccac                                                   20


<210> 10071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 10071
tgtactttct gtctgacacc                                                   20


<210> 10072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 10072
actggaacgg ttgatgaata                                                   20


<210> 10073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10073
gtctctcact ggaacggttg                                                   20


<210> 10074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10074
tttcttacat aaagcatgaa                                                   20


<210> 10075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10075
tagagtttct tacataaagc                                                   20


<210> 10076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 10076
cttaattcag aagtatcaat                                                   20


<210> 10077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 10077
gatatcaaag tttagttcag                                                   20


<210> 10078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ACGAGT

<400> 10078
catccacttt gtaaccaatg                                                   20


<210> 10079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10079
ctagagaaat aaatgtagcc                                                   20


<210> 10080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 10080
ctaatttcta tatcataaaa                                                   20


<210> 10081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 10081
cagtactggc aaaaggaaca                                                   20


<210> 10082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 10082
aaagctgcta cagtgtgaat                                                   20


<210> 10083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 10083
atatagaaag ctgctacagt                                                   20


<210> 10084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 10084
gtgaagaaga ctttagaagt                                                   20


<210> 10085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 10085
aaagcataat gaatacccta                                                   20


<210> 10086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10086
atgaaacatt agaaagcata                                                   20


<210> 10087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 10087
tgatcctgac tgtgttctgt                                                   20


<210> 10088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10088
gcaaacccag aaggcttttt                                                   20


<210> 10089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 10089
tgacaaccta ggtattcttt                                                   20


<210> 10090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10090
aaaattattt ttaaagtggt                                                   20


<210> 10091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGAT

<400> 10091
gagatcataa atatcagcat                                                   20


<210> 10092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 10092
tgaaatcttc cctcctgtct                                                   20


<210> 10093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 10093
attgcatggg tctttaggat                                                   20


<210> 10094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 10094
taatcaattg catgggtctt                                                   20


<210> 10095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 10095
ctttgagttt aatcaattgc                                                   20


<210> 10096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 10096
tcattatcaa aagtcaacct                                                   20


<210> 10097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 10097
tcagtcattc caggtgagag                                                   20


<210> 10098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 10098
caatttcagt cattccaggt                                                   20


<210> 10099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 10099
gtctcagcat tgagaacatt                                                   20


<210> 10100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 10100
cccctattac agatatgtga                                                   20


<210> 10101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 10101
actcataact ccaactattt                                                   20


<210> 10102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 10102
gtttcagctc ttcgaacttt                                                   20


<210> 10103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 10103
ttaattctac aggtatttaa                                                   20


<210> 10104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 10104
tcatagactc tatctaaatt                                                   20


<210> 10105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 10105
ctgtattttg tttgcatcaa                                                   20


<210> 10106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10106
ttgtttacgc atttaagtgt                                                   20


<210> 10107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 10107
gtctaaatta ccataatgtt                                                   20


<210> 10108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10108
ttgtctattt ggattttttt                                                   20


<210> 10109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 10109
atctctatgg atttgtctat                                                   20


<210> 10110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 10110
ctcatctatg ttttatctct                                                   20


<210> 10111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 10111
gagccaccta gacaatacag                                                   20


<210> 10112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10112
tctattttcc gttaatgact                                                   20


<210> 10113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 10113
caaatgtatt tatcagaaaa                                                   20


<210> 10114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10114
ttccaagttc ttgtttaaaa                                                   20


<210> 10115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 10115
cctccatgct cagcacttgg                                                   20


<210> 10116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 10116
tcttcctcca tgctcagcac                                                   20


<210> 10117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 10117
ggggtctgat ttttccagca                                                   20


<210> 10118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 10118
ttccaataac agcaaacctc                                                   20


<210> 10119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 10119
ttcgtgaccc gtggaactgg                                                   20


<210> 10120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 10120
tgcaagaggc ttctgtgtag                                                   20


<210> 10121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10121
ttttactgga atatatactt                                                   20


<210> 10122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 10122
gtgtttaggt acacttttac                                                   20


<210> 10123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 10123
tttcacatct agtatcccaa                                                   20


<210> 10124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 10124
atagacctat tgtagtttaa                                                   20


<210> 10125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 10125
tattgacatt ttaatatttt                                                   20


<210> 10126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 10126
ttcaagtacc tctgctttct                                                   20


<210> 10127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 10127
gtgtattttt aaatgattgg                                                   20


<210> 10128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 10128
atgggtgtat ttttaaatga                                                   20


<210> 10129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 10129
ggtgtatgtt ttataattat                                                   20


<210> 10130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 10130
atgttacaca tattttattc                                                   20


<210> 10131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 10131
gatgctacag tgttttctca                                                   20


<210> 10132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 10132
ttactgcatt tatgaagatg                                                   20


<210> 10133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 10133
ggaccaaaaa tgtcgagtaa                                                   20


<210> 10134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TCGAGT

<400> 10134
accggactgg accaaaaatg                                                   20


<210> 10135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10135
caaactgcat atttatgacc                                                   20


<210> 10136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 10136
aaatagtcta caagctcatt                                                   20


<210> 10137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 10137
gagtggcaat attaagattt                                                   20


<210> 10138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 10138
tgggtctcag agaagactgg                                                   20


<210> 10139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 10139
tattattaat ataatttgtc                                                   20


<210> 10140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 10140
tctcctttca gtcctctaag                                                   20


<210> 10141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 10141
tgatgtgaaa aattgatatt                                                   20


<210> 10142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 10142
tgacattgga accacattgc                                                   20


<210> 10143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 10143
ttactatgaa gaagtggact                                                   20


<210> 10144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 10144
aaattgaact cagtgattgg                                                   20


<210> 10145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 10145
attaccgtgg ttagtaagtg                                                   20


<210> 10146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 10146
aatggctaca ataacatttc                                                   20


<210> 10147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 10147
gctatggaaa aggacactta                                                   20


<210> 10148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 10148
tggttgtttt tatttcttaa                                                   20


<210> 10149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 10149
caaccggaga aaaataaggc                                                   20


<210> 10150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 10150
ctgactcaca gacttacctc                                                   20


<210> 10151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 10151
aaataatttt ccatgtaaaa                                                   20


<210> 10152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 10152
ctactgagat ttaagacaaa                                                   20


<210> 10153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10153
tacaattgca gaaagaatgg                                                   20


<210> 10154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 10154
tcaatacaat tgcagaaaga                                                   20


<210> 10155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 10155
catgtcaata caattgcaga                                                   20


<210> 10156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGAT

<400> 10156
aggtccctcc cctgagacgt                                                   20


<210> 10157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 10157
gatttaattt actcactgtt                                                   20


<210> 10158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 10158
ctataaagaa ctacctgaga                                                   20


<210> 10159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 10159
cggggattca ccgtgttagc                                                   20


<210> 10160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGAT

<400> 10160
tttgtatttt tagtagagac                                                   20


<210> 10161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 10161
cattctccca cctcagcctc                                                   20


<210> 10162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CCGGGT

<400> 10162
ctcactgcaa gctccgcctc                                                   20


<210> 10163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 10163
tctccctctg ttgcccaggc                                                   20


<210> 10164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 10164
tttttttttt ttttttgaga                                                   20


<210> 10165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10165
tcatttttct aggaagttcc                                                   20


<210> 10166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 10166
atcacttaaa agtttttaat                                                   20


<210> 10167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 10167
tccttcacat cccttgtaag                                                   20


<210> 10168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 10168
attcttccta cacatgagca                                                   20


<210> 10169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10169
gtagcttgat ggggatggca                                                   20


<210> 10170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGAT

<400> 10170
aaagtcattg gtagcttgat                                                   20


<210> 10171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 10171
ccagctttgt tcttttggct                                                   20


<210> 10172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 10172
tggtaccagt accatgctgt                                                   20


<210> 10173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 10173
ccagcaccat ttgttaaata                                                   20


<210> 10174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 10174
ttttgtataa ggtgtaagga                                                   20


<210> 10175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10175
gtttaagtct ttaatccatc                                                   20


<210> 10176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 10176
gtaatgcctg ggttttcttc                                                   20


<210> 10177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 10177
tatgtcctga atggtaatgc                                                   20


<210> 10178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 10178
tccttgccca tgcctatgtc                                                   20


<210> 10179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 10179
ggatattagc cttttgtcag                                                   20


<210> 10180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 10180
gtttgagttc attgtagatt                                                   20


<210> 10181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 10181
tttttttctt gtaaatttgt                                                   20


<210> 10182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 10182
gtcctttgcc cactttttga                                                   20


<210> 10183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 10183
tttctagttc tagatccctg                                                   20


<210> 10184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 10184
tatacccagt aatgggatgg                                                   20


<210> 10185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 10185
tttgggtata tacccagtaa                                                   20


<210> 10186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 10186
gcagcatgat ttatagtcct                                                   20


<210> 10187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 10187
ggttccaagt gtttgctatt                                                   20


<210> 10188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 10188
agtctatcat tgttggacat                                                   20


<210> 10189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 10189
tattcttgtg atagtttact                                                   20


<210> 10190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 10190
ttcaattccc acctatgagt                                                   20


<210> 10191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 10191
tcattgttca attcccacct                                                   20


<210> 10192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 10192
ccccacccca ccacagtccc                                                   20


<210> 10193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 10193
tttaattata ctttaagttt                                                   20


<210> 10194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 10194
atatatatat ataggatatt                                                   20


<210> 10195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 10195
tatatatata tatatatata                                                   20


<210> 10196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 10196
gtgaataacc atatcatgac                                                   20


<210> 10197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 10197
attgagatta gtgaaattta                                                   20


<210> 10198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 10198
cctactatgc agacaaaaag                                                   20


<210> 10199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 10199
tgaagaggaa ttaaaatata                                                   20


<210> 10200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 10200
tcttatgtga ggagctgaag                                                   20


<210> 10201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 10201
gaagcgtaaa cttcaaattt                                                   20


<210> 10202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 10202
taaatataga cgaaaagaag                                                   20


<210> 10203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10203
tttaaaagag gaaagttgag                                                   20


<210> 10204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 10204
agacttttaa aagaggaaag                                                   20


<210> 10205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 10205
ggtaaaacag catcaggctg                                                   20


<210> 10206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 10206
tgaagtgaca gcagaggatt                                                   20


<210> 10207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 10207
acattgttga agtgacagca                                                   20


<210> 10208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 10208
aagaaagtgg tttcgtgaga                                                   20


<210> 10209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 10209
cgcggtaact tgaatggatg                                                   20


<210> 10210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 10210
gccatctcgc ggtaacttga                                                   20


<210> 10211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10211
tgctgccatc tcgcggtaac                                                   20


<210> 10212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 10212
gatggagcct aaaattgtga                                                   20


<210> 10213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 10213
ggtggaaata gcaagagaat                                                   20


<210> 10214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 10214
agatgtggtg gaaatagcaa                                                   20


<210> 10215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 10215
atgagttgat tccaactctc                                                   20


<210> 10216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 10216
aacattaata ggaaattgga                                                   20


<210> 10217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 10217
tacaaacatt aataggaaat                                                   20


<210> 10218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 10218
taaattgaaa atcttctgga                                                   20


<210> 10219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 10219
catagatagt gattcctctg                                                   20


<210> 10220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 10220
attctgtagc ctatgggcca                                                   20


<210> 10221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 10221
tataaataga acaacaaagc                                                   20


<210> 10222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 10222
aatcattcag aaaatctctt                                                   20


<210> 10223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 10223
aattatatta tttaattatt                                                   20


<210> 10224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 10224
atttatcgtt cagaaaatct                                                   20


<210> 10225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGAT

<400> 10225
acaggctgac tctcttgtta                                                   20


<210> 10226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 10226
gtctaacagc cttctactag                                                   20


<210> 10227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 10227
atctagctaa gatcattgat                                                   20


<210> 10228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10228
tgtgctactc cagtgaacac                                                   20


<210> 10229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 10229
actaagtact tagccaagtt                                                   20


<210> 10230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 10230
ccctaatgtt caagtaaagg                                                   20


<210> 10231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 10231
tgttactgtg gtaattgttt                                                   20


<210> 10232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10232
ctttcagaat catcctactt                                                   20


<210> 10233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 10233
ataacttact ctttaccttt                                                   20


<210> 10234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CCGAGT

<400> 10234
tgtaccaagt agtggaattg                                                   20


<210> 10235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 10235
cttgagtctg taccaagtag                                                   20


<210> 10236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 10236
gacatatgtt ttaaattccc                                                   20


<210> 10237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10237
gtgtttactt tttggctagt                                                   20


<210> 10238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 10238
ctttatccat ttattcattg                                                   20


<210> 10239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10239
gctaaatact aattcagtgt                                                   20


<210> 10240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CGGGGT

<400> 10240
tttggctctg tgttctttca                                                   20


<210> 10241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 10241
attctggaca tttcataaga                                                   20


<210> 10242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGAT

<400> 10242
atactctaca ttttgtttct                                                   20


<210> 10243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 10243
caatcatcat tatgtagttt                                                   20


<210> 10244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 10244
aggacaattt tcacatattt                                                   20


<210> 10245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 10245
tatgatttcc aaaagtgttg                                                   20


<210> 10246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 10246
tggtaccctc cagttgaatg                                                   20


<210> 10247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10247
aaagagatgg taccctccag                                                   20


<210> 10248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 10248
atcaaactgg taatggacat                                                   20


<210> 10249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 10249
gaggagaata ggaatattgg                                                   20


<210> 10250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 10250
agacagagac agaggagaat                                                   20


<210> 10251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 10251
tgggggagac agagacagag                                                   20


<210> 10252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGGT

<400> 10252
gctgtgttga gcatgtgcat                                                   20


<210> 10253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 10253
agtttcacct ctccaaacta                                                   20


<210> 10254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 10254
gtattcattt tcacttttat                                                   20


<210> 10255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 10255
tattgtactt tttttatttt                                                   20


<210> 10256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 10256
gcctgggcct cccaaagttc                                                   20


<210> 10257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 10257
ttttgtactt ttagtagaga                                                   20


<210> 10258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 10258
ctcactgcaa gctccgcctc                                                   20


<210> 10259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 10259
tctcgctcta ttgcccaggc                                                   20


<210> 10260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CGGAGT

<400> 10260
ctttatttat ttatttgaga                                                   20


<210> 10261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ACGAAT

<400> 10261
aaaattattt ggcaatataa                                                   20


<210> 10262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10262
gacacctgag attactgtct                                                   20


<210> 10263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 10263
taacccttac tgttaggatt                                                   20


<210> 10264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 10264
tttagtgtaa cccttactgt                                                   20


<210> 10265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 10265
catctatctg tgtgtataac                                                   20


<210> 10266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 10266
caaagtatat tttctttctt                                                   20


<210> 10267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 10267
aattgtaaat taaacatgac                                                   20


<210> 10268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 10268
actgccttta tatgcaacat                                                   20


<210> 10269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 10269
taatatgaga ttaatggtga                                                   20


<210> 10270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 10270
tctctaatat gagattaatg                                                   20


<210> 10271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 10271
ctataggaaa tcttagatac                                                   20


<210> 10272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 10272
atagaaaata agaaagagtt                                                   20


<210> 10273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 10273
tgcatacata gaaaataaga                                                   20


<210> 10274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 10274
ggacagacat agatccatag                                                   20


<210> 10275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 10275
cagagagtgt gataaacaca                                                   20


<210> 10276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 10276
caatggaaat ttgaaggcca                                                   20


<210> 10277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 10277
ttctgctttg atctcctcac                                                   20


<210> 10278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 10278
agaaattcta acattctcag                                                   20


<210> 10279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 10279
cattattgaa taaataatcc                                                   20


<210> 10280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10280
caatgttttc tgcaacatta                                                   20


<210> 10281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 10281
aaaatggaca tggataccct                                                   20


<210> 10282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 10282
tggttctagc taaaatggac                                                   20


<210> 10283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 10283
tatggatgag gagtagataa                                                   20


<210> 10284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 10284
cattttagga tgtatggatg                                                   20


<210> 10285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 10285
caggctacat tttaggatgt                                                   20


<210> 10286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 10286
ctgacaggca ggctacattt                                                   20


<210> 10287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 10287
caaatcctct cttgaaagag                                                   20


<210> 10288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 10288
ctgtctcctc aaatttctct                                                   20


<210> 10289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 10289
cacaaagcat gacctttacc                                                   20


<210> 10290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 10290
attctggtaa agtgcccctt                                                   20


<210> 10291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 10291
atagaacgtt tctagcacct                                                   20


<210> 10292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 10292
tgagactaat gtcgaacaac                                                   20


<210> 10293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 10293
ttttagcttg atgactcttg                                                   20


<210> 10294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 10294
ttaatgctct aaactttcac                                                   20


<210> 10295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 10295
gataataggt tgtctgataa                                                   20


<210> 10296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10296
agataaaaag gagttaaatt                                                   20


<210> 10297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 10297
cttaaaaaaa aaagataaaa                                                   20


<210> 10298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10298
gttcaagttc atgcctcatt                                                   20


<210> 10299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 10299
gaagaacaca tcaaactcaa                                                   20


<210> 10300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 10300
aacatggttt gatctagagg                                                   20


<210> 10301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGGT

<400> 10301
actgccttca atgtaagata                                                   20


<210> 10302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 10302
cttgttactt aaactttagc                                                   20


<210> 10303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 10303
gttggattta tacctttaaa                                                   20


<210> 10304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 10304
tttctaagta attctatggg                                                   20


<210> 10305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 10305
tttcatttct aagtaattct                                                   20


<210> 10306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 10306
aactttctaa tttgaaaatg                                                   20


<210> 10307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 10307
ccctttaaag ccattatcta                                                   20


<210> 10308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 10308
tatatggtgt ttgaaaggtg                                                   20


<210> 10309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10309
aagaagaaat attaataaaa                                                   20


<210> 10310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 10310
acacaatctt tactgtaact                                                   20


<210> 10311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 10311
catctcaaag ctcactatgg                                                   20


<210> 10312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 10312
taaaacatta attttgtgtt                                                   20


<210> 10313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 10313
cattacctaa cataagtgaa                                                   20


<210> 10314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 10314
accctggtca atagccacag                                                   20


<210> 10315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 10315
tgatttaaca aaatcaaatg                                                   20


<210> 10316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10316
attgaatttt ttctctcctt                                                   20


<210> 10317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10317
aaacttttct actttttgaa                                                   20


<210> 10318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10318
tccaaaaact tttctacttt                                                   20


<210> 10319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 10319
actgtgcctg gtctattgaa                                                   20


<210> 10320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10320
gagccactgt gcctggtcta                                                   20


<210> 10321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 10321
gccttggcct ccgaaaatgt                                                   20


<210> 10322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 10322
ttttgtactt ttcctagaga                                                   20


<210> 10323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 10323
tttttttttt ttttttgaga                                                   20


<210> 10324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10324
caaaatatgt gttgtttcta                                                   20


<210> 10325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CGGAGT

<400> 10325
aattgaacat aatagagact                                                   20


<210> 10326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 10326
tgaatgatgc ttaaaatgtt                                                   20


<210> 10327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10327
aatgaagtga tataagtgac                                                   20


<210> 10328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 10328
agattttgcc aggctataat                                                   20


<210> 10329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 10329
caaaagaact tggagagaat                                                   20


<210> 10330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 10330
atgcctcaaa agaacttgga                                                   20


<210> 10331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 10331
gtttggagga tgagggatga                                                   20


<210> 10332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 10332
acaggtttgg aggatgaggg                                                   20


<210> 10333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 10333
gctgacaggt ttggaggatg                                                   20


<210> 10334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 10334
ctttagagct gacaggtttg                                                   20


<210> 10335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 10335
tgcttgacaa cagattgact                                                   20


<210> 10336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 10336
cttgattatt ttacagcatc                                                   20


<210> 10337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10337
agtatctttg tcctttcttt                                                   20


<210> 10338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 10338
aggattttat tcattttaca                                                   20


<210> 10339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 10339
atatattgta actgttgctg                                                   20


<210> 10340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 10340
ccagtgtgaa ttgttctgta                                                   20


<210> 10341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 10341
tgtgagccac tgaaaccagt                                                   20


<210> 10342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 10342
gagaggttat gtcatctcca                                                   20


<210> 10343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 10343
ttaactcaat ttttcaaact                                                   20


<210> 10344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10344
ttaataatct tatgagctcc                                                   20


<210> 10345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 10345
aaagcaagga attaaaatag                                                   20


<210> 10346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 10346
tgataaaatt atccaaagca                                                   20


<210> 10347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 10347
gatcatttag ctagtaagta                                                   20


<210> 10348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 10348
aatcagaaaa gttgcttaac                                                   20


<210> 10349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 10349
cctaaatgcc tcaacatttt                                                   20


<210> 10350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 10350
gagcaatcaa cagtcattct                                                   20


<210> 10351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 10351
aacaacaaag gtgaaatgat                                                   20


<210> 10352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10352
accctgttca gcaatattca                                                   20


<210> 10353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 10353
tcagaagata aaccaagtgt                                                   20


<210> 10354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 10354
atatttcttt gcttgaagga                                                   20


<210> 10355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 10355
tcagagccat accaggcaca                                                   20


<210> 10356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 10356
tgcttccaat atttgacttc                                                   20


<210> 10357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGAT

<400> 10357
aagggttttc atagtacctt                                                   20


<210> 10358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 10358
ctatagattt tccctatgtg                                                   20


<210> 10359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 10359
tttacttcag tgatttttta                                                   20


<210> 10360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 10360
atcatttggg aactgcagtt                                                   20


<210> 10361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 10361
atactctaac tgagccacaa                                                   20


<210> 10362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 10362
tatctgggag atatttttaa                                                   20


<210> 10363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 10363
aaaggaaaca tactgtttaa                                                   20


<210> 10364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 10364
ctccttgaaa taagaaaata                                                   20


<210> 10365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 10365
aaaacagcct gaaattatta                                                   20


<210> 10366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 10366
acaggtaaga ggctcagtga                                                   20


<210> 10367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 10367
aattctcctg cctcagcctc                                                   20


<210> 10368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 10368
ctcactgcaa cctctgcctg                                                   20


<210> 10369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 10369
tcccgctctc tggttcaggc                                                   20


<210> 10370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 10370
atttatttat ttatttgaga                                                   20


<210> 10371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 10371
ttctgattct atggtgcctt                                                   20


<210> 10372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 10372
atcaatggta cacattgtca                                                   20


<210> 10373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 10373
aggtattttg tagaatgttc                                                   20


<210> 10374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 10374
agtataggtt aggtattttg                                                   20


<210> 10375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 10375
tgatgatgtt gatactttga                                                   20


<210> 10376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 10376
tttttgatga tgttgatact                                                   20


<210> 10377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 10377
acaaatgccc ttaccctatt                                                   20


<210> 10378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 10378
ttttgcttaa acttttgtct                                                   20


<210> 10379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 10379
ttattacctt tatttaatat                                                   20


<210> 10380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 10380
aaaactgatc agcatttcta                                                   20


<210> 10381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 10381
taagctcatt cctgacccag                                                   20


<210> 10382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 10382
agtatgctta ccatggttga                                                   20


<210> 10383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 10383
accttaacgg catcattaag                                                   20


<210> 10384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 10384
gctcagtaaa atgagaatct                                                   20


<210> 10385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 10385
tgttcagagc tcagtaaaat                                                   20


<210> 10386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 10386
ttaagcgtat ccttgtcagc                                                   20


<210> 10387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 10387
gggcttttgt agttataaac                                                   20


<210> 10388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 10388
ggtgatgtta tcgaacatag                                                   20


<210> 10389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 10389
atcatgggaa gtcttatgtt                                                   20


<210> 10390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 10390
tttcatggga gaaggcctat                                                   20


<210> 10391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 10391
cttggtgcca agacatagaa                                                   20


<210> 10392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 10392
tttatcttgt tattgacata                                                   20


<210> 10393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10393
aattgtactt cttattgtct                                                   20


<210> 10394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 10394
aattcaagga gcacatagga                                                   20


<210> 10395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 10395
ttataattca aggagcacat                                                   20


<210> 10396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 10396
ataagtgtaa ccctgacagc                                                   20


<210> 10397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10397
tgtagacatc ctgccaagga                                                   20


<210> 10398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 10398
aatgctgtag acatcctgcc                                                   20


<210> 10399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 10399
tcctatttgg ctatttctcc                                                   20


<210> 10400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 10400
tatgaggtgg tgccaggacc                                                   20


<210> 10401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 10401
ctttgataaa gaatagtcag                                                   20


<210> 10402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 10402
aactatggct tactttgata                                                   20


<210> 10403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 10403
gatgttattt aagcaaagtg                                                   20


<210> 10404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 10404
tctcaagctc caagactccc                                                   20


<210> 10405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 10405
agtcaagaac ctttagttat                                                   20


<210> 10406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10406
ggggtttcac agacctttca                                                   20


<210> 10407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGGT

<400> 10407
gaaaatgaaa agttttgtca                                                   20


<210> 10408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 10408
actgcaacct gggcaacaga                                                   20


<210> 10409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 10409
ttgcactgca acctgggcaa                                                   20


<210> 10410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 10410
gggaggtcgc ttgagtgcac                                                   20


<210> 10411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 10411
ttgggaaggt gggaggtcgc                                                   20


<210> 10412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 10412
agggcagatc acttgagccc                                                   20


<210> 10413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 10413
gtaagataaa acaagataag                                                   20


<210> 10414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 10414
tactgaatct agactagggg                                                   20


<210> 10415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 10415
aattacaacc attgttttta                                                   20


<210> 10416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 10416
gaggtgttgt agtgaggaaa                                                   20


<210> 10417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 10417
atcagggcta gaggtctggg                                                   20


<210> 10418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 10418
atgagatgtg aaggacatct                                                   20


<210> 10419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 10419
atagttaaat tgtgacacag                                                   20


<210> 10420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 10420
ggctaaagat acactgcttg                                                   20


<210> 10421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 10421
tttcactctc tctaatgttc                                                   20


<210> 10422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 10422
aacacagaat tccttcactc                                                   20


<210> 10423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 10423
ccaatactgg gatgaaaaca                                                   20


<210> 10424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 10424
acaaaccatg taaccaatac                                                   20


<210> 10425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10425
tatcctaaaa atatagtttg                                                   20


<210> 10426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 10426
atgagtacta ggtctaatac                                                   20


<210> 10427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 10427
aagatcagga aaaataacca                                                   20


<210> 10428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 10428
ggaacctttc aaatacagta                                                   20


<210> 10429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 10429
caatgattaa ttctctcaac                                                   20


<210> 10430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 10430
gtagtcattt ttcacctttg                                                   20


<210> 10431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 10431
ttcatataca aataatggta                                                   20


<210> 10432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 10432
attgtacatt aagggaattc                                                   20


<210> 10433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 10433
tatactatat tgtacattaa                                                   20


<210> 10434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGGT

<400> 10434
ttattttcat aacttgctgc                                                   20


<210> 10435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 10435
aaatgaaatg aacctattaa                                                   20


<210> 10436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 10436
gtattttaaa atatctgttg                                                   20


<210> 10437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 10437
aacaataaca aacaacaaaa                                                   20


<210> 10438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 10438
gactgtaagc cctagaggac                                                   20


<210> 10439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 10439
aaactgttaa cacaagaggg                                                   20


<210> 10440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 10440
aaaaatgaag gagacagctc                                                   20


<210> 10441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 10441
ttttcttgtt tggaaaagtt                                                   20


<210> 10442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 10442
gtacaggaat agaaaatcta                                                   20


<210> 10443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 10443
tttgaagact agacaagtac                                                   20


<210> 10444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 10444
catcctttaa aatttttaat                                                   20


<210> 10445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 10445
cttgaggtta aaaaaatctg                                                   20


<210> 10446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 10446
ataacaattg gccacaaact                                                   20


<210> 10447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 10447
acaggtagag tggcagagaa                                                   20


<210> 10448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 10448
gaaaaacagg tagagtggca                                                   20


<210> 10449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 10449
gcatgggaat gaaaaacagg                                                   20


<210> 10450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 10450
ttataatggt tgctaagcat                                                   20


<210> 10451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10451
ttagatgtat ttacaacaac                                                   20


<210> 10452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 10452
aaatgtctgg taatatacac                                                   20


<210> 10453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 10453
tccaagaagg ttggggactg                                                   20


<210> 10454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 10454
taatgcctga tcatctgaag                                                   20


<210> 10455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 10455
tattgtgaac tgcacatacg                                                   20


<210> 10456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 10456
agcccagtga acattaccac                                                   20


<210> 10457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGGT

<400> 10457
aggccacagt gggttagatc                                                   20


<210> 10458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 10458
ggatctgttt ataggccaca                                                   20


<210> 10459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 10459
aagccacaga tccataaaac                                                   20


<210> 10460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 10460
ggagtaaatt aataaaattt                                                   20


<210> 10461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 10461
agtcctaaag aaatgtgtta                                                   20


<210> 10462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 10462
aaagtaaagg gaagatcaaa                                                   20


<210> 10463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 10463
agagtatata agattagctt                                                   20


<210> 10464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 10464
gtggttgggt gttgtcgatt                                                   20


<210> 10465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 10465
ggatattgat aacagagtgg                                                   20


<210> 10466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 10466
tacattgagg atattgataa                                                   20


<210> 10467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 10467
tcttcataca tcactacatt                                                   20


<210> 10468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 10468
aatatgttga ggaaaaatat                                                   20


<210> 10469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10469
tataaagaag agtgaatcat                                                   20


<210> 10470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 10470
aatccagttt ataaagaaga                                                   20


<210> 10471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 10471
taataatcca gtttataaag                                                   20


<210> 10472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 10472
tagcactatt aaataaattc                                                   20


<210> 10473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 10473
gaatatgaaa caaaagttac                                                   20


<210> 10474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 10474
aagtagtgat ggaaagttag                                                   20


<210> 10475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 10475
ataagaagga agattggata                                                   20


<210> 10476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 10476
attctagata agaaggaaga                                                   20


<210> 10477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 10477
ccacggcagg tgtcaaggct                                                   20


<210> 10478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 10478
accacttaaa ataacaggag                                                   20


<210> 10479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 10479
gcctcaccac ttaaaataac                                                   20


<210> 10480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10480
taaagggcaa cagaatccat                                                   20


<210> 10481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 10481
aagttcaaag taaagggcaa                                                   20


<210> 10482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 10482
tgtacataga cccagcacaa                                                   20


<210> 10483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 10483
tactggtcac tgctgccaca                                                   20


<210> 10484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 10484
tggagattta ttggaagttg                                                   20


<210> 10485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 10485
atgataggaa caatattgaa                                                   20


<210> 10486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 10486
caaaataaaa gttttggact                                                   20


<210> 10487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 10487
aagcagtgtg tatatttaaa                                                   20


<210> 10488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 10488
tgatttcatt tttaaaaact                                                   20


<210> 10489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 10489
aatttaattt taaaatattt                                                   20


<210> 10490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 10490
ttcttaaaat aaatatattc                                                   20


<210> 10491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 10491
aactccacct ggaggtaggg                                                   20


<210> 10492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 10492
aaaacatttc catttatggt                                                   20


<210> 10493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 10493
gaacataggc tttaactata                                                   20


<210> 10494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 10494
gaatggagaa aagagaaaat                                                   20


<210> 10495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10495
gatgttctca ttaatgaatg                                                   20


<210> 10496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10496
acttcacgat gttctcatta                                                   20


<210> 10497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 10497
tttagcaaaa gagtaagtcc                                                   20


<210> 10498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 10498
ggtattgtgt tctttagcaa                                                   20


<210> 10499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 10499
aattatatgc actcaaagaa                                                   20


<210> 10500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 10500
gaaatgtatt ttatcccttg                                                   20


<210> 10501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 10501
taattatttt tacatttgtc                                                   20


<210> 10502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 10502
gggaaaaagt ccgtattgaa                                                   20


<210> 10503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 10503
ttgaatgtat taaagataaa                                                   20


<210> 10504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10504
ccattgctta caaagagttg                                                   20


<210> 10505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 10505
gatgccctcc attgcttaca                                                   20


<210> 10506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 10506
aggattatgc aatttgaaag                                                   20


<210> 10507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 10507
cattccatat cttttagcaa                                                   20


<210> 10508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 10508
ctgactttta aaataaccca                                                   20


<210> 10509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 10509
tctttaatag atgcagttga                                                   20


<210> 10510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 10510
ctgttcagac tctactaatg                                                   20


<210> 10511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 10511
ggtaatacaa atataaattg                                                   20


<210> 10512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 10512
ttgttgcaga gaccctatga                                                   20


<210> 10513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 10513
tattgtaaca cgccttccag                                                   20


<210> 10514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10514
tactttttta tggcatagcc                                                   20


<210> 10515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 10515
tctactgccg taataaaaat                                                   20


<210> 10516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10516
ttaagctcac atgacttaat                                                   20


<210> 10517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 10517
atattgaaaa tggtgaaaac                                                   20


<210> 10518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 10518
tgtgataaat tttatgaaca                                                   20


<210> 10519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 10519
aaattcaatc ttttcaattc                                                   20


<210> 10520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 10520
ttagttatga gtttgtacct                                                   20


<210> 10521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 10521
actcttgttt atgtttagtt                                                   20


<210> 10522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 10522
actaacacag ctggaagtcc                                                   20


<210> 10523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 10523
atcattattt atcattaact                                                   20


<210> 10524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 10524
tttcatattc aagaaaggaa                                                   20


<210> 10525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 10525
attgtccctc agtatcagtg                                                   20


<210> 10526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 10526
aaatgtttac ctctacaaat                                                   20


<210> 10527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 10527
tccatgttcc catgagggag                                                   20


<210> 10528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 10528
tggtggatat attggaagcc                                                   20


<210> 10529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 10529
acagttagtg attagccttg                                                   20


<210> 10530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 10530
gcttaatcac tggatgacac                                                   20


<210> 10531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 10531
caaagcttag agcttaatca                                                   20


<210> 10532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 10532
tttattaagt gtactataaa                                                   20


<210> 10533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 10533
aatgagttag tgtcaatgcc                                                   20


<210> 10534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 10534
taatcagtca atattttcca                                                   20


<210> 10535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 10535
ccctctagac tatgtgaaaa                                                   20


<210> 10536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CCGAGT

<400> 10536
ctcatctcac ttctggaatc                                                   20


<210> 10537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 10537
ttggatgctc atctcacttc                                                   20


<210> 10538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 10538
tcagatacct gaaagtaatc                                                   20


<210> 10539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 10539
ttcctctcat aagaaatcac                                                   20


<210> 10540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 10540
caaacacagg atgtccaaaa                                                   20


<210> 10541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 10541
tctcccaggc atctcaaaca                                                   20


<210> 10542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 10542
cagcctccca ttttaagttc                                                   20


<210> 10543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 10543
accattagcc tcttgggact                                                   20


<210> 10544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 10544
catacgacca tatccatctg                                                   20


<210> 10545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 10545
tagcttttca gtgttggagt                                                   20


<210> 10546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 10546
gtgacctagc ttttcagtgt                                                   20


<210> 10547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 10547
ttttcatact cattttaccg                                                   20


<210> 10548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 10548
tattggttca agtatgattc                                                   20


<210> 10549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 10549
aacaataata gaggtatgta                                                   20


<210> 10550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 10550
tttctctctt gtatcctggg                                                   20


<210> 10551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 10551
tgaaaagact cccatacaag                                                   20


<210> 10552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 10552
gcatagatat gctttgctgc                                                   20


<210> 10553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 10553
ttgcagttgt tacaattgat                                                   20


<210> 10554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 10554
gtgggcatgt ccctttcata                                                   20


<210> 10555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 10555
ataagcccta aatcaatgcc                                                   20


<210> 10556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 10556
aagtggggca gggggtacaa                                                   20


<210> 10557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGGT

<400> 10557
acattatagg aagtggggca                                                   20


<210> 10558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 10558
acgctttagt ttccttagtt                                                   20


<210> 10559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 10559
tttttttcta tactggcctg                                                   20


<210> 10560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 10560
agtctgctga ataaagccaa                                                   20


<210> 10561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 10561
aatttctaaa ctcaagtctg                                                   20


<210> 10562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10562
ccagataaac tactcactga                                                   20


<210> 10563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGAT

<400> 10563
cttttttcaa ttaacttcct                                                   20


<210> 10564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 10564
ctgtgataca ttatatatca                                                   20


<210> 10565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 10565
aattcattat agttaacaga                                                   20


<210> 10566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 10566
tatcatttat tggggtgaaa                                                   20


<210> 10567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 10567
agatgcttga tatcatttat                                                   20


<210> 10568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 10568
tatgctacct ctctagatag                                                   20


<210> 10569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 10569
tcatttactc aggttcatac                                                   20


<210> 10570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 10570
gttttcaagc tgtaatactg                                                   20


<210> 10571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 10571
aattataaat tataaaattt                                                   20


<210> 10572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 10572
tagtagttga gaaagtaaaa                                                   20


<210> 10573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 10573
ttttaaaaaa ttcaaaaacc                                                   20


<210> 10574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 10574
atgcactact gcactacagc                                                   20


<210> 10575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10575
ggctgaggtg ggagggtcac                                                   20


<210> 10576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 10576
tacttgagag gctgaggtgg                                                   20


<210> 10577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CCGGGT

<400> 10577
aaaaaataga caaaacttag                                                   20


<210> 10578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 10578
tgggtggatc acttgagccc                                                   20


<210> 10579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 10579
actttgggag gctgaggtgg                                                   20


<210> 10580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 10580
cagcactttg ggaggctgag                                                   20


<210> 10581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 10581
gcagttataa aaataaaata                                                   20


<210> 10582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10582
tagatatgtc taagttattc                                                   20


<210> 10583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 10583
cctttggtaa gaaaaatgaa                                                   20


<210> 10584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 10584
ctcttagcag tgtctctttg                                                   20


<210> 10585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 10585
tcccacagca actgtgaact                                                   20


<210> 10586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 10586
aaatctccca gactttgtaa                                                   20


<210> 10587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10587
agattaatgt tattgatgaa                                                   20


<210> 10588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 10588
cgaaaccttt cttgtatttc                                                   20


<210> 10589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 10589
caaaacaata taagagagat                                                   20


<210> 10590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGGT

<400> 10590
gttgaccatt ggcacattga                                                   20


<210> 10591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 10591
tgtttgtaac acttaattat                                                   20


<210> 10592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 10592
attgctatta ttgagctggt                                                   20


<210> 10593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10593
ataatctgtg gtttccaaag                                                   20


<210> 10594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 10594
tctccaggga agctttggtg                                                   20


<210> 10595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 10595
atggacaggg acatgtttgc                                                   20


<210> 10596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 10596
cgtttttgca gcatgaaggt                                                   20


<210> 10597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 10597
ttcaattaat ctgatgttga                                                   20


<210> 10598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10598
aattagtgta attatttcat                                                   20


<210> 10599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 10599
ttttgaaata aaacattgat                                                   20


<210> 10600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 10600
tgtaaagtct cctaaaagct                                                   20


<210> 10601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 10601
cttgactttg agatgatgta                                                   20


<210> 10602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 10602
ccctcggcct cccaaagtgc                                                   20


<210> 10603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 10603
aaacatcctg tctcagcctc                                                   20


<210> 10604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 10604
atctcactct gtctcccagg                                                   20


<210> 10605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGAT

<400> 10605
cacaataata taatgaagat                                                   20


<210> 10606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 10606
attttgagat ttaatatgta                                                   20


<210> 10607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 10607
aatctgttat ctcacaagta                                                   20


<210> 10608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 10608
tactgtaact aaagcaaagt                                                   20


<210> 10609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 10609
gctagtttag tttagttgat                                                   20


<210> 10610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GCGAAT

<400> 10610
cttgaaggac tattttctaa                                                   20


<210> 10611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GCGGAT

<400> 10611
aaggttaaac aattctaatg                                                   20


<210> 10612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 10612
tataatgatg atttatagag                                                   20


<210> 10613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10613
acacaagatc taacatgctg                                                   20


<210> 10614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 10614
ttccagaaaa gagacatgaa                                                   20


<210> 10615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 10615
tttctttccc tgtttgcaca                                                   20


<210> 10616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 10616
gccttctcct cccacatatt                                                   20


<210> 10617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 10617
gctgcttcac atcaggggca                                                   20


<210> 10618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 10618
attttaactc ctggagtaat                                                   20


<210> 10619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 10619
ggctgtaata ttttaactcc                                                   20


<210> 10620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 10620
tttttttgct acccttccac                                                   20


<210> 10621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 10621
agagattctg tgaaagaaca                                                   20


<210> 10622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 10622
aaaaaattac atttgtagca                                                   20


<210> 10623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 10623
aactctccat gaattaaaat                                                   20


<210> 10624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10624
atgaacatct gtaactctcc                                                   20


<210> 10625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GCGGAT

<400> 10625
ggtgaaagtt ttcaaaagag                                                   20


<210> 10626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 10626
ataaatacct tcatcttcaa                                                   20


<210> 10627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 10627
atcgttagaa gatattctct                                                   20


<210> 10628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 10628
atttagtagc cattttagtg                                                   20


<210> 10629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 10629
tcaaaagccc agaggagcag                                                   20


<210> 10630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGAT

<400> 10630
attgattaag gcaggggaaa                                                   20


<210> 10631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 10631
atgatctttg ctattgcatt                                                   20


<210> 10632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 10632
acattttcta ctggacagta                                                   20


<210> 10633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 10633
aatgtgcttg gttttgttgt                                                   20


<210> 10634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 10634
atttgaaata tccatctctt                                                   20


<210> 10635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 10635
tggagaaatg ggacagacac                                                   20


<210> 10636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 10636
gaatgggcta taaagacggc                                                   20


<210> 10637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 10637
gaataagaag aaagagagag                                                   20


<210> 10638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 10638
aaaaataaaa gatcccaaag                                                   20


<210> 10639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 10639
gtaggtgtaa ttggaaacaa                                                   20


<210> 10640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 10640
agcaatgatt catgaaccct                                                   20


<210> 10641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 10641
tctgcatgaa aacctatccc                                                   20


<210> 10642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 10642
cactaggcat gttgatctcc                                                   20


<210> 10643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGGT

<400> 10643
caaggctttc ctccccaacc                                                   20


<210> 10644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 10644
ttattactca ggaaaaatga                                                   20


<210> 10645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 10645
ccaggtaatt tagacacttc                                                   20


<210> 10646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 10646
tgggttacga ttggctacca                                                   20


<210> 10647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 10647
aatgcctgtg aagaatgggg                                                   20


<210> 10648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 10648
atgaacttta aatgcctgtg                                                   20


<210> 10649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 10649
ttattataca agttctagat                                                   20


<210> 10650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 10650
atgtaggtcc tggacttatc                                                   20


<210> 10651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 10651
taactaattt tcattggctc                                                   20


<210> 10652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 10652
aataagagta tatgaaaaat                                                   20


<210> 10653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 10653
ttaaatgagc gggttaaaat                                                   20


<210> 10654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GCGGGT

<400> 10654
actggcaatc atttaaatga                                                   20


<210> 10655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 10655
tactctattc tgagttccca                                                   20


<210> 10656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 10656
tgattagatg ttactctatt                                                   20


<210> 10657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 10657
aaaagcaaag ggaaagggtt                                                   20


<210> 10658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 10658
aaagagaaaa agcaaaggga                                                   20


<210> 10659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 10659
ttctgtggat aagacaaaat                                                   20


<210> 10660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 10660
ctgacagtac tatatattct                                                   20


<210> 10661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 10661
accacttagg acaggccctt                                                   20


<210> 10662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 10662
tcctagatag gtgggtggga                                                   20


<210> 10663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 10663
tgagtcctag ataggtgggt                                                   20


<210> 10664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 10664
ggatcttgag tcctagatag                                                   20


<210> 10665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 10665
atagccacct atctaggatc                                                   20


<210> 10666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 10666
ttggagcata gccacctatc                                                   20


<210> 10667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 10667
cttggactgg ctcctgaggg                                                   20


<210> 10668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 10668
acctctgcct cccaaagtgt                                                   20


<210> 10669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 10669
tgtatttttt ttagtagaga                                                   20


<210> 10670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CGGGAT

<400> 10670
gcctcagcct tccgaggagc                                                   20


<210> 10671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 10671
gctcaccgca atctccgctc                                                   20


<210> 10672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CGGAGT

<400> 10672
tgtttgtttg tttgttttga                                                   20


<210> 10673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 10673
ttatgtcaaa tcatgatgag                                                   20


<210> 10674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 10674
aagatggtca cagcttgggg                                                   20


<210> 10675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10675
ctaaatatgg gagtagaaag                                                   20


<210> 10676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 10676
taccccattg ggctaaatat                                                   20


<210> 10677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 10677
tagagaaaga gtgtatacaa                                                   20


<210> 10678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 10678
tttaaagtaa ggaatagaga                                                   20


<210> 10679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 10679
gtttccttct ttttaaagta                                                   20


<210> 10680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 10680
tgtagagaga ttctaatttt                                                   20


<210> 10681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 10681
atagtctact tagggttttt                                                   20


<210> 10682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 10682
cattgccctt atagtctact                                                   20


<210> 10683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 10683
gcctcggcct tccaaagtgc                                                   20


<210> 10684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 10684
ttttgtattt ttagtagaga                                                   20


<210> 10685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 10685
gcctcagcct cctgagtagc                                                   20


<210> 10686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 10686
aattcttctg cctcagcctc                                                   20


<210> 10687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 10687
ttcactcttg ttgcccaggc                                                   20


<210> 10688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 10688
tttttatttt ttttgtgaga                                                   20


<210> 10689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 10689
tatagacaag tccacgaacc                                                   20


<210> 10690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 10690
catagaattt ttgtagtata                                                   20


<210> 10691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 10691
atgcaggaat aatagaatca                                                   20


<210> 10692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 10692
aattatccat gcaggaataa                                                   20


<210> 10693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 10693
tactggtaaa ttatccatgc                                                   20


<210> 10694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10694
tctctcctta cataaaaagc                                                   20


<210> 10695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 10695
taaaggcaga atgcccagac                                                   20


<210> 10696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 10696
aaagagaaag ctgttaaagg                                                   20


<210> 10697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 10697
tgtgtttctg aggcacatat                                                   20


<210> 10698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 10698
cctaaaatca gcagagatga                                                   20


<210> 10699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 10699
cttctcatat tcttaaattt                                                   20


<210> 10700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 10700
tcatttacaa aatttcatta                                                   20


<210> 10701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 10701
agagctcaat tcaatgtgtc                                                   20


<210> 10702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 10702
agagaatgtg tttacaaaca                                                   20


<210> 10703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 10703
agtgggcaag atgattgaca                                                   20


<210> 10704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10704
taaaatgttc tttttgagct                                                   20


<210> 10705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10705
gattttttta aaacttagat                                                   20


<210> 10706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 10706
tcatttcacc accctgatgt                                                   20


<210> 10707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 10707
acaaagtcag gaaatgtaat                                                   20


<210> 10708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 10708
aagactgatg aatccagcca                                                   20


<210> 10709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10709
cttgtccata gcaaagactg                                                   20


<210> 10710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 10710
caacccccaa gactaatgac                                                   20


<210> 10711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 10711
gctctaaaga cttggatgta                                                   20


<210> 10712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 10712
gggcacttgg ctctaaagac                                                   20


<210> 10713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 10713
ccaatctaat caagaagggt                                                   20


<210> 10714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 10714
ttgtttccaa tctaatcaag                                                   20


<210> 10715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10715
gtaaacatat cacactatac                                                   20


<210> 10716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 10716
gtgtttctta agaaacgcca                                                   20


<210> 10717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ACGGGT

<400> 10717
tagttttttc tccccatttt                                                   20


<210> 10718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 10718
tccataagtc agataaatcc                                                   20


<210> 10719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 10719
gaatagaaca gtctttaaag                                                   20


<210> 10720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10720
aacaagcatg taaaacttta                                                   20


<210> 10721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 10721
tatttctggt cttgtagcaa                                                   20


<210> 10722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 10722
aatatttcta tacttcagta                                                   20


<210> 10723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 10723
acatttttaa tcagttcatt                                                   20


<210> 10724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 10724
gtatcttgat cagtatatag                                                   20


<210> 10725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 10725
ttctaaaata ggctctgatt                                                   20


<210> 10726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10726
atctggagac ccgttttcag                                                   20


<210> 10727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 10727
ttatcaattg ttggtggcaa                                                   20


<210> 10728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 10728
acttcggcct cccaaagtgc                                                   20


<210> 10729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGGT

<400> 10729
tttttgtatt tttgaaggga                                                   20


<210> 10730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10730
aagggtctct tgttcattga                                                   20


<210> 10731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10731
gacaaagggt ctcttgttca                                                   20


<210> 10732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 10732
caaatttcct attgcagaca                                                   20


<210> 10733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 10733
taaacgtaga ataatgtagc                                                   20


<210> 10734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 10734
acctttgggg aaattaaacg                                                   20


<210> 10735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 10735
tcagataaag ggaacattat                                                   20


<210> 10736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 10736
aaagcaagta atcaggtgat                                                   20


<210> 10737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10737
aaagagaagc tgatgaaggg                                                   20


<210> 10738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 10738
gggagaaaga gaagctgatg                                                   20


<210> 10739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 10739
gaaataaagc actgtagaag                                                   20


<210> 10740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 10740
aatttcctgt ctatgaagtt                                                   20


<210> 10741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 10741
tagcgtgctt cttcaagtgc                                                   20


<210> 10742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 10742
atgtaaaatc aatgatagtt                                                   20


<210> 10743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 10743
tgaggagaaa aagagcaatt                                                   20


<210> 10744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 10744
gcacatatca gcctccataa                                                   20


<210> 10745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 10745
ggggaaacag gttgtaatag                                                   20


<210> 10746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 10746
atttgtgtaa tcccaaatta                                                   20


<210> 10747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 10747
tgctgtgaac ttaaaaactt                                                   20


<210> 10748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 10748
ttaaatactt gatcgctttg                                                   20


<210> 10749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 10749
gttagggtta atcaaccatc                                                   20


<210> 10750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 10750
tttaatggca aaaattaagt                                                   20


<210> 10751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 10751
tttctgcaaa taaatgtgtc                                                   20


<210> 10752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 10752
aaaaaaatca gtaattttct                                                   20


<210> 10753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 10753
agctatgatt gcaccacagc                                                   20


<210> 10754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 10754
tcatatcact gcactccagc                                                   20


<210> 10755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 10755
agaggcagag gttgcagtga                                                   20


<210> 10756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 10756
tatatataaa agaagacagg                                                   20


<210> 10757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10757
ccttggcaaa caagaaaata                                                   20


<210> 10758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 10758
gttactgcat aattccttta                                                   20


<210> 10759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 10759
atgccactgc actccagact                                                   20


<210> 10760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10760
ggctgaggca ggagaatcac                                                   20


<210> 10761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 10761
tactcaggag gctgaggcag                                                   20


<210> 10762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 10762
gaaaagaggc agaggctgag                                                   20


<210> 10763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 10763
tgtacagtag ctctgaggag                                                   20


<210> 10764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 10764
aatataaggt ttatttagaa                                                   20


<210> 10765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 10765
gtattaatat aaggtttatt                                                   20


<210> 10766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 10766
ccattatgtg tgtaaaaatg                                                   20


<210> 10767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10767
gaacttgaat gaatgaatga                                                   20


<210> 10768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10768
gaatgaactt gaatgaatga                                                   20


<210> 10769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10769
tctggaatga acttgaatga                                                   20


<210> 10770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10770
tatgtctgga atgaacttga                                                   20


<210> 10771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10771
aaaatatgtc tggaatgaac                                                   20


<210> 10772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 10772
tagttcctct aaaatatgtc                                                   20


<210> 10773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 10773
ttactaactg ctctgatgct                                                   20


<210> 10774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 10774
acttaaaaat gttctgttct                                                   20


<210> 10775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 10775
gctatttatg gggaaaaaat                                                   20


<210> 10776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 10776
tattcttcaa aaataaatat                                                   20


<210> 10777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 10777
atttttcgtt atacatactt                                                   20


<210> 10778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 10778
tgggaaacat tgaagagtga                                                   20


<210> 10779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 10779
tggatggctg ggaaacattg                                                   20


<210> 10780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 10780
gttgtccaca ggggaggaat                                                   20


<210> 10781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 10781
actgtggttg tccacagggg                                                   20


<210> 10782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGGT

<400> 10782
accacatgga tggatacaca                                                   20


<210> 10783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 10783
atgctgataa aaccacatgg                                                   20


<210> 10784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 10784
atacatgctg ataaaaccac                                                   20


<210> 10785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10785
ttatttgcat gaaaagaaaa                                                   20


<210> 10786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 10786
ggtatgaaac aatgtttata                                                   20


<210> 10787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 10787
tgtgggaatg actaaataat                                                   20


<210> 10788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 10788
acctaaatgt tctacagtgt                                                   20


<210> 10789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 10789
gttacaaaaa gagcccacaa                                                   20


<210> 10790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGAT

<400> 10790
gtggagggtg gcaggaggga                                                   20


<210> 10791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 10791
ctggggccca ttggagggtg                                                   20


<210> 10792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 10792
acacacactg gggcccattg                                                   20


<210> 10793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 10793
cgtactgtga aactattcaa                                                   20


<210> 10794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 10794
cgttacacta ggtaacaaaa                                                   20


<210> 10795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 10795
aaagatcagc agagttaggg                                                   20


<210> 10796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 10796
ttcttaaaga tcagcagagt                                                   20


<210> 10797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 10797
acctgtttct taaagatcag                                                   20


<210> 10798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGGT

<400> 10798
tcaactgtca tggcactggt                                                   20


<210> 10799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGAT

<400> 10799
cttcttctgg tcattgtcat                                                   20


<210> 10800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 10800
ggtggtgaac ttcttggaac                                                   20


<210> 10801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 10801
tggtcattaa gagtgagggg                                                   20


<210> 10802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 10802
taatgaagaa gttggtcatt                                                   20


<210> 10803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 10803
agctaacttc ttgactagtg                                                   20


<210> 10804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 10804
caagctttat tcgatggcca                                                   20


<210> 10805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 10805
ggattgatag gcctttatga                                                   20


<210> 10806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 10806
acacattgtt tggggagagc                                                   20


<210> 10807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 10807
aaaattagcc gggtgtggtg                                                   20


<210> 10808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CCGGGT

<400> 10808
actaaaggta caaaaattag                                                   20


<210> 10809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 10809
tgggtggatc acatgaggtc                                                   20


<210> 10810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 10810
actttgggaa gctgagatgg                                                   20


<210> 10811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 10811
cagcactttg ggaagctgag                                                   20


<210> 10812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CCGGGT

<400> 10812
aagaattaag aagttttcgg                                                   20


<210> 10813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 10813
aaaatgcaaa ctaaaatgat                                                   20


<210> 10814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 10814
aaaaagcaca aatggcatct                                                   20


<210> 10815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 10815
gctaatttta ttattttgtt                                                   20


<210> 10816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 10816
agccactgga gaaaggattg                                                   20


<210> 10817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 10817
aacacaggag ccactggaga                                                   20


<210> 10818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 10818
gtcattacaa ggtttgaggg                                                   20


<210> 10819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 10819
cttttttctt ttcacctgag                                                   20


<210> 10820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 10820
taacccaaga tacattttag                                                   20


<210> 10821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 10821
tgggacacct gggtagtcat                                                   20


<210> 10822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 10822
aatagttatc attgggacac                                                   20


<210> 10823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 10823
aaatagacat agttacatat                                                   20


<210> 10824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 10824
ataatgttat tttatgcaaa                                                   20


<210> 10825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 10825
gggaaattgt acacacataa                                                   20


<210> 10826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 10826
cccatttgga attagataat                                                   20


<210> 10827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 10827
aaaatagaaa ttttcccatt                                                   20


<210> 10828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 10828
agaggtatta aaaaaagagt                                                   20


<210> 10829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 10829
taaagaagag gtattaaaaa                                                   20


<210> 10830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 10830
ttaacattag aggttctaaa                                                   20


<210> 10831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 10831
ttaacataat gttacttatg                                                   20


<210> 10832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 10832
taagaaataa taattatttt                                                   20


<210> 10833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10833
tactataaaa tgccataaaa                                                   20


<210> 10834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 10834
aaatagtccc tatcagttgt                                                   20


<210> 10835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 10835
tcacaatatt ttaataatca                                                   20


<210> 10836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 10836
tataatataa atgattatta                                                   20


<210> 10837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 10837
tttcatttct tataaacttg                                                   20


<210> 10838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 10838
gcctcggctt cccaaagtgc                                                   20


<210> 10839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10839
ccatgttggt caggctggtc                                                   20


<210> 10840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CGGGGT

<400> 10840
ttttgtattt ttagtagaga                                                   20


<210> 10841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 10841
gcctcagcct cctgagtagc                                                   20


<210> 10842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 10842
agttctcctg cctcagcctc                                                   20


<210> 10843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CCGGGT

<400> 10843
agctcactac aatccacctc                                                   20


<210> 10844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 10844
ttcgctcttg ttgcccaggc                                                   20


<210> 10845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 10845
tttttttttt ttttttgaga                                                   20


<210> 10846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 10846
acactaatct taagttttcc                                                   20


<210> 10847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10847
tgctgtacag ataagacttt                                                   20


<210> 10848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 10848
agtcttaact aacagagaga                                                   20


<210> 10849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 10849
ttctctctaa ttatttaaat                                                   20


<210> 10850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 10850
atgttgatgt tttgagggaa                                                   20


<210> 10851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 10851
atgctgcaga gctaattata                                                   20


<210> 10852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 10852
atttctctct ttcatttatg                                                   20


<210> 10853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 10853
tttcagtctg tatagggaag                                                   20


<210> 10854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 10854
tggagccatg aatttaacaa                                                   20


<210> 10855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10855
gcctctctca ctctggagcc                                                   20


<210> 10856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 10856
aagctagtaa gcagtagaga                                                   20


<210> 10857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 10857
tttccactaa aataacctta                                                   20


<210> 10858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 10858
attttagtct ttaaaatatt                                                   20


<210> 10859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 10859
aggcccacat cctgtagaca                                                   20


<210> 10860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 10860
ttatcaaacc tgatggattt                                                   20


<210> 10861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 10861
atccacattt atcaaacctg                                                   20


<210> 10862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 10862
cataattctg ctcagtccta                                                   20


<210> 10863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10863
cttggatttt gccttcttga                                                   20


<210> 10864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10864
tgtgcttgga ttttgccttc                                                   20


<210> 10865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 10865
atcagcagct gttactgtgc                                                   20


<210> 10866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 10866
ttaacaattc ctgccccatc                                                   20


<210> 10867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10867
ttaactcact tattttgata                                                   20


<210> 10868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 10868
caatgtccac aaatgttcca                                                   20


<210> 10869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 10869
atgtcttcat caaaaatctt                                                   20


<210> 10870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10870
tagtacttta ccatctccag                                                   20


<210> 10871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 10871
tcatattccc agattatggt                                                   20


<210> 10872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 10872
tgcattttaa acaatatcac                                                   20


<210> 10873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 10873
tttaacaaca acaacagaaa                                                   20


<210> 10874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10874
aatagccata ccctttatct                                                   20


<210> 10875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 10875
cctgtgattg ttatctaatt                                                   20


<210> 10876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 10876
atataaattt gaggaaggat                                                   20


<210> 10877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 10877
tctggaatat aaatttgagg                                                   20


<210> 10878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 10878
ttaggcaaaa cacttccttc                                                   20


<210> 10879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 10879
tataaatttg atcaggagtc                                                   20


<210> 10880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 10880
tctggaatat aaatttgatc                                                   20


<210> 10881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 10881
ttaataattt taattccttc                                                   20


<210> 10882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 10882
cctatgcact tgctttatct                                                   20


<210> 10883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10883
aaagttaagc acctttgtca                                                   20


<210> 10884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 10884
gaacaggtca attcatcagt                                                   20


<210> 10885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 10885
ggcaatacct tttcccactg                                                   20


<210> 10886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 10886
ttttgttaaa gtgttttcag                                                   20


<210> 10887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 10887
gatcaatgat ttctactatt                                                   20


<210> 10888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 10888
tgagtaaaca aattgaatta                                                   20


<210> 10889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10889
ttaatacttg agtaaacaaa                                                   20


<210> 10890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 10890
acagagaagg tgcttaatac                                                   20


<210> 10891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 10891
tagatatgat taaatcaaac                                                   20


<210> 10892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10892
tatccttgcc tagctagtta                                                   20


<210> 10893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 10893
taggagaatt cctgatggga                                                   20


<210> 10894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 10894
taaatatact agcaatttag                                                   20


<210> 10895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 10895
ttataccagt attaaaactt                                                   20


<210> 10896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 10896
ccagagatct ggtttttagt                                                   20


<210> 10897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 10897
atataattcg tagactctaa                                                   20


<210> 10898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 10898
caattatttt ctcccatcat                                                   20


<210> 10899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 10899
tttatttttt gttgaggagt                                                   20


<210> 10900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 10900
tgcttgttta ttttttgttg                                                   20


<210> 10901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 10901
tattcctatc agcaatgcac                                                   20


<210> 10902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 10902
tataccctaa agtagaattg                                                   20


<210> 10903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 10903
ttaggatgta taccctaaag                                                   20


<210> 10904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 10904
cgtcccttct attaattgtt                                                   20


<210> 10905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 10905
gttcatctgt tgatagacat                                                   20


<210> 10906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 10906
atccgggtcg tagcatatat                                                   20


<210> 10907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CCGGGT

<400> 10907
aatgttttca aggtgttcat                                                   20


<210> 10908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10908
accactattc tactttctct                                                   20


<210> 10909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 10909
acggatctca aaacacgcta                                                   20


<210> 10910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ACGGAT

<400> 10910
ttactgactc tttctgcctt                                                   20


<210> 10911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 10911
aaggagacac cgcatgttgt                                                   20


<210> 10912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 10912
cattttggaa acttaatggt                                                   20


<210> 10913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 10913
ataagacaaa gattacaatt                                                   20


<210> 10914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 10914
ctcttcctgt ctgtaatgga                                                   20


<210> 10915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 10915
atattctctt cctgtctgta                                                   20


<210> 10916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 10916
aactggatct ctttctggac                                                   20


<210> 10917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 10917
atgagtgtgc tcttttttaa                                                   20


<210> 10918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 10918
gggtacaact ttggaaaggg                                                   20


<210> 10919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 10919
gcatgggtac aactttggaa                                                   20


<210> 10920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 10920
ccaatgctaa aattaccagc                                                   20


<210> 10921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 10921
agggtttttc ttgattttgt                                                   20


<210> 10922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 10922
caagattgaa agcagaagat                                                   20


<210> 10923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 10923
gggagctagc taaacaactg                                                   20


<210> 10924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 10924
aaaaatttta tacagggtat                                                   20


<210> 10925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 10925
gtggtctgaa aaattttata                                                   20


<210> 10926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 10926
aaaaacaata aaacaggaca                                                   20


<210> 10927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 10927
ctcagcattt atactcttcc                                                   20


<210> 10928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 10928
agggcagtgg taagcggctg                                                   20


<210> 10929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 10929
gcctccaaaa tgtgtaggtc                                                   20


<210> 10930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 10930
caactgattt atcttagcct                                                   20


<210> 10931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 10931
aatgtggtct gtatataaaa                                                   20


<210> 10932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 10932
aaatgatcat caacagataa                                                   20


<210> 10933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 10933
tatgatccag caattgaaat                                                   20


<210> 10934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 10934
aagcattgtc cactgttggt                                                   20


<210> 10935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 10935
aaaaagtgaa aggtgttgtt                                                   20


<210> 10936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 10936
tcaatctatt ttagtgattt                                                   20


<210> 10937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 10937
aaccatggga aatttggccc                                                   20


<210> 10938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 10938
tccacttaga tactgtactt                                                   20


<210> 10939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 10939
aatgcaagaa gttgactttt                                                   20


<210> 10940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 10940
atttagatat tctatattgg                                                   20


<210> 10941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 10941
aaaagcaaag tgatcttgtg                                                   20


<210> 10942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 10942
tctgaaatgg agaagaaaca                                                   20


<210> 10943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 10943
aaaaaaatta aaaaaatgtc                                                   20


<210> 10944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 10944
ttctcgggag gctgaggcag                                                   20


<210> 10945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 10945
caggctgatc acttgaggtc                                                   20


<210> 10946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 10946
ggaaatatgt ataaaatgtc                                                   20


<210> 10947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 10947
tagaaaagat ttgaaaaaag                                                   20


<210> 10948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 10948
tgacttcact ttcctggtct                                                   20


<210> 10949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10949
ttttgaagtt gttttatagg                                                   20


<210> 10950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 10950
aagtttgaag acattatgaa                                                   20


<210> 10951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGGT

<400> 10951
ttcttggaca ccaattcctg                                                   20


<210> 10952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 10952
aaaacaacaa aaaaagaaag                                                   20


<210> 10953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 10953
aaagaaatct tatatattcc                                                   20


<210> 10954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10954
actcacaatg gttactaaac                                                   20


<210> 10955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 10955
gctaactgag cagtttgtta                                                   20


<210> 10956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 10956
acctcggcct tctaaagtgt                                                   20


<210> 10957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TCGAAT

<400> 10957
ccatgttggc cagactagtc                                                   20


<210> 10958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 10958
ttttgcagtt ttagtagaga                                                   20


<210> 10959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 10959
gcctcagcct cccaagtagc                                                   20


<210> 10960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 10960
tttcactctg ttgcccaggc                                                   20


<210> 10961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 10961
taagtttcaa ggtacatttg                                                   20


<210> 10962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 10962
gcctaggccc cccaaagtgc                                                   20


<210> 10963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 10963
ggcaggctgg tcttgaactc                                                   20


<210> 10964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 10964
ttttgtattt ttagtagaga                                                   20


<210> 10965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CGGGAT

<400> 10965
gcctcagcct cccgagtagc                                                   20


<210> 10966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CCGAGT

<400> 10966
aattctcctg cctcagcctc                                                   20


<210> 10967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 10967
ttcactcttg ttgcccaggc                                                   20


<210> 10968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CCGAGT

<400> 10968
tctttttttt ttttttgaga                                                   20


<210> 10969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 10969
tatctaggca tttaataact                                                   20


<210> 10970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 10970
cttacacatg ataagtagat                                                   20


<210> 10971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 10971
actatattat atgttatata                                                   20


<210> 10972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 10972
aaaagcacag ataaataaat                                                   20


<210> 10973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 10973
agatcagctg acagactttt                                                   20


<210> 10974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 10974
ggcctactca gggatcaact                                                   20


<210> 10975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 10975
aaaagggaag tggcctactc                                                   20


<210> 10976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10976
aatattataa agttgaagtg                                                   20


<210> 10977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 10977
ttggtaagtg atgcctttat                                                   20


<210> 10978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10978
ttgaggacat tttgaatagg                                                   20


<210> 10979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 10979
tttattgagg acattttgaa                                                   20


<210> 10980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 10980
gataatttat tgaggacatt                                                   20


<210> 10981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 10981
acagtgtatc ttttagggct                                                   20


<210> 10982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 10982
gctggaggat tgcttgatcc                                                   20


<210> 10983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 10983
actttgggag gccgaggctg                                                   20


<210> 10984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 10984
agatattcaa atccatgcag                                                   20


<210> 10985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 10985
cttcttgaga gtctatactt                                                   20


<210> 10986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 10986
taaaaatatg tcatcttctt                                                   20


<210> 10987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 10987
tttaactggg ggtaatttca                                                   20


<210> 10988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGGT

<400> 10988
ttattattat tattttaact                                                   20


<210> 10989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 10989
gcctcgacct cccaaagtgc                                                   20


<210> 10990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 10990
cggagtttca ccatgttagc                                                   20


<210> 10991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CGGAGT

<400> 10991
ttttgtattt ttagtagaga                                                   20


<210> 10992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CCGAGT

<400> 10992
ccattctcct gcctcagcct                                                   20


<210> 10993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 10993
ctcactgcaa gctccgcgtc                                                   20


<210> 10994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 10994
tctcgctctg tcgcccaggc                                                   20


<210> 10995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CGGAGT

<400> 10995
tattttttat ttttttgaga                                                   20


<210> 10996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 10996
agttagcatc ctgccctgca                                                   20


<210> 10997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 10997
tgttcacttg gaaatttaga                                                   20


<210> 10998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 10998
aataaagctc taattgcacc                                                   20


<210> 10999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 10999
tggatttttt acaaagcttt                                                   20


<210> 11000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 11000
aatttcttta aaatgtctcc                                                   20


<210> 11001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 11001
ttgaattgac atatgtagaa                                                   20


<210> 11002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 11002
ataatctgcc acagacaagt                                                   20


<210> 11003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 11003
ataaagtggg gaaggaagag                                                   20


<210> 11004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 11004
tttggaggaa tgaaaccctt                                                   20


<210> 11005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 11005
aaaggtggaa tgaagtttgg                                                   20


<210> 11006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 11006
cagctcttgg cagctaaagg                                                   20


<210> 11007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 11007
atgtgggtag aatacttttg                                                   20


<210> 11008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 11008
gagcatccag agaatgtggg                                                   20


<210> 11009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 11009
tatgagagca tccagagaat                                                   20


<210> 11010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 11010
aggatttatg agagcatcca                                                   20


<210> 11011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 11011
tgtataaaaa tattttatat                                                   20


<210> 11012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 11012
catcttcctt tagaactgtg                                                   20


<210> 11013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 11013
tgctctgaag aggacatatt                                                   20


<210> 11014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 11014
ttatttcact aattgtgagc                                                   20


<210> 11015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 11015
tgattgtgtc attttcatac                                                   20


<210> 11016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 11016
tgaagaccca tcactgttat                                                   20


<210> 11017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11017
ccagtcaata gtcactgact                                                   20


<210> 11018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 11018
aaatatattt taagaaaaaa                                                   20


<210> 11019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11019
agcatattaa ccctggaaac                                                   20


<210> 11020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 11020
tacaaaaata tggattcttc                                                   20


<210> 11021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 11021
aaataataaa atacaaaaat                                                   20


<210> 11022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGGT

<400> 11022
gtgcctggca tcaagtagta                                                   20


<210> 11023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 11023
ttcattgttg acttagcttc                                                   20


<210> 11024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 11024
ttacagcatg caggtatttt                                                   20


<210> 11025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 11025
ggtcatcatc ataatttact                                                   20


<210> 11026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 11026
tttcctccca tcttcattat                                                   20


<210> 11027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 11027
aaaagagtgt gaagtgctag                                                   20


<210> 11028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 11028
tattcctatt agttatgcaa                                                   20


<210> 11029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11029
agtagaattt ttcattttac                                                   20


<210> 11030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 11030
ctctgtggca aggaaaaaag                                                   20


<210> 11031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 11031
aaattcagaa gagcaatcag                                                   20


<210> 11032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 11032
ttttactacc tgttgctgtg                                                   20


<210> 11033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 11033
gatgcttcta cagaagaaag                                                   20


<210> 11034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 11034
atggtgcagg gctaggctca                                                   20


<210> 11035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 11035
gtgatgtgtt tttacagtga                                                   20


<210> 11036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11036
atatggtatt tgatgtaaag                                                   20


<210> 11037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 11037
atcaacaaca aaactctaga                                                   20


<210> 11038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 11038
aagtgatagc ttgtcagtta                                                   20


<210> 11039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGGT

<400> 11039
aatttacatg agaaacttag                                                   20


<210> 11040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 11040
tcatttactt ttaggaaaaa                                                   20


<210> 11041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TCGAAT

<400> 11041
agaatccttt taacttttta                                                   20


<210> 11042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 11042
agtgaaattc agaaaagatg                                                   20


<210> 11043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TCGAAT

<400> 11043
cagattattt atttattttt                                                   20


<210> 11044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 11044
tttatttctg tttacgctag                                                   20


<210> 11045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 11045
gttctgaaac tgtggaaagg                                                   20


<210> 11046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 11046
tcctgtgcgg ttttgactct                                                   20


<210> 11047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CCGGGT

<400> 11047
aagagagggg agaagcttga                                                   20


<210> 11048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGAT

<400> 11048
attctgcagg tgcactgggt                                                   20


<210> 11049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 11049
agccagattc tgcaggtgca                                                   20


<210> 11050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 11050
tcggctgagg ctgggctagc                                                   20


<210> 11051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 11051
ggggacccgg gcgcgctggg                                                   20


<210> 11052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGGT

<400> 11052
agggagggag ggagggagca                                                   20


<210> 11053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 11053
ccccgccctg cgccgcccgc                                                   20


<210> 11054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 11054
cgccaccacc gcgcccctag                                                   20


<210> 11055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 11055
gccccaccca atgggtggcc                                                   20


<210> 11056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 11056
acacacacac gccccaccca                                                   20


<210> 11057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGGT

<400> 11057
aggaaaggga tgatgggggc                                                   20


<210> 11058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 11058
gctgagcagg aagggaggaa                                                   20


<210> 11059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CGGAGT

<400> 11059
ggtccccacc tcctctgctc                                                   20


<210> 11060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TCGGGT

<400> 11060
ctgatggcat attcagataa                                                   20


<210> 11061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11061
acgcacacac tccacacaaa                                                   20


<210> 11062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 11062
cagcagggaa aagtagaccc                                                   20


<210> 11063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11063
aatagcacat cttacaagtc                                                   20


<210> 11064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 11064
tttgtccagg atatggcact                                                   20


<210> 11065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 11065
ggaagagaag gcgatttgtc                                                   20


<210> 11066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11066
aaataaaatt ttaaaaataa                                                   20


<210> 11067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 11067
gggggaggct attcttgtgt                                                   20


<210> 11068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 11068
acaaatgttt cattctggtg                                                   20


<210> 11069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 11069
tatatatttg cctaacccca                                                   20


<210> 11070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 11070
ctctgtaaga tactgtaatg                                                   20


<210> 11071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 11071
agatgaataa gtggaacaca                                                   20


<210> 11072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11072
gccaggggtt gaaatgggag                                                   20


<210> 11073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGGT

<400> 11073
taaaatgatc agtacttgcc                                                   20


<210> 11074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 11074
attctgtatt attgcaacta                                                   20


<210> 11075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 11075
aaagcatatt gctaagtgaa                                                   20


<210> 11076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 11076
actatggtac caccagtcaa                                                   20


<210> 11077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11077
agatgtcctt cagtaggtga                                                   20


<210> 11078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 11078
aacaagatgt ccttcagtag                                                   20


<210> 11079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 11079
aactctcatg tattgctggt                                                   20


<210> 11080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 11080
gatgatatca agttctggcc                                                   20


<210> 11081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 11081
agataccacc acatatgtat                                                   20


<210> 11082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11082
tgcattatat attccactct                                                   20


<210> 11083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 11083
ttgttaatgg atgcttaaag                                                   20


<210> 11084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 11084
agaatagtaa gttcttgtta                                                   20


<210> 11085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 11085
aacaagaacc tagatatatt                                                   20


<210> 11086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 11086
tttttggttt tatcattttc                                                   20


<210> 11087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 11087
ggatccctca gtcagaccaa                                                   20


<210> 11088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 11088
ctcacaggga aaatcctgca                                                   20


<210> 11089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11089
gaaagaaaat tgggaaaata                                                   20


<210> 11090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 11090
cagctaatgt tctgtagact                                                   20


<210> 11091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 11091
aatttggaaa gatacttttt                                                   20


<210> 11092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 11092
attcttattc ctattctggt                                                   20


<210> 11093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 11093
attgtggaaa atacagaagt                                                   20


<210> 11094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 11094
ttattcttct attttcacaa                                                   20


<210> 11095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 11095
tataatttga agttctactt                                                   20


<210> 11096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 11096
gacactgggg aaaattcttc                                                   20


<210> 11097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 11097
attatcagca aaaccattgt                                                   20


<210> 11098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 11098
ctaatggaag acttctacaa                                                   20


<210> 11099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 11099
tcactttctt tctcttctct                                                   20


<210> 11100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 11100
tttttgtttt cacacaattg                                                   20


<210> 11101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 11101
ctgtagttct ttctctggct                                                   20


<210> 11102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11102
actatccctg tgtgaggtcc                                                   20


<210> 11103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 11103
gtcttttcac tttgactggg                                                   20


<210> 11104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 11104
gctaagataa gacccttctg                                                   20


<210> 11105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 11105
atttttattt gtcataactg                                                   20


<210> 11106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 11106
tttgtcataa ctgtggaatt                                                   20


<210> 11107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11107
caggacagcc actcacaaca                                                   20


<210> 11108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 11108
ataaatgtct gattttaatg                                                   20


<210> 11109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11109
agaaagcact ggcactgtat                                                   20


<210> 11110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11110
ctggcactgt ataagaatgt                                                   20


<210> 11111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 11111
acttgtagac agtaatagta                                                   20


<210> 11112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 11112
gagtttgtaa aatctttgct                                                   20


<210> 11113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 11113
aaaatctttg ctgaggattt                                                   20


<210> 11114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 11114
ataataatgg agaaatatta                                                   20


<210> 11115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 11115
tccactctgg ctactgtact                                                   20


<210> 11116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11116
aatagatttg gaagtgaggc                                                   20


<210> 11117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 11117
gatttggaag tgaggcaaga                                                   20


<210> 11118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 11118
taaagaggtt aaaggtggta                                                   20


<210> 11119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 11119
aggttaaagg tggtaatgga                                                   20


<210> 11120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 11120
atttacatta cattaggtgg                                                   20


<210> 11121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 11121
ggtagaatga actggtcttg                                                   20


<210> 11122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 11122
ggtcttggtg aataaatgcg                                                   20


<210> 11123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 11123
aaatgcggag ggttaatgaa                                                   20


<210> 11124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 11124
aagaggatta gtttggaaaa                                                   20


<210> 11125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11125
ggattagttt ggaaaactgg                                                   20


<210> 11126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGAT

<400> 11126
gttgtccctt agtatctgct                                                   20


<210> 11127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 11127
gattggcttc tggactccct                                                   20


<210> 11128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 11128
ctacacatca cttcatttgt                                                   20


<210> 11129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 11129
gttttgcctt ttggggcttt                                                   20


<210> 11130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 11130
ttccccaact atttctgatc                                                   20


<210> 11131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 11131
tatttctgat ccagaattgg                                                   20


<210> 11132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 11132
gaatccacag atcagaaacc                                                   20


<210> 11133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 11133
gaaaccatgg atatggagga                                                   20


<210> 11134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 11134
cctccatttg aagacacagt                                                   20


<210> 11135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 11135
tctattatta tctctgactc                                                   20


<210> 11136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 11136
caagcatgta acatgctaaa                                                   20


<210> 11137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 11137
aaagtgaatt atgttactct                                                   20


<210> 11138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 11138
ttggcctaca ttttaaaggc                                                   20


<210> 11139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 11139
ttgcccattt tctttggctt                                                   20


<210> 11140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11140
aatttgtaag gtgctttgcc                                                   20


<210> 11141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 11141
tttgccaaga ataaggtgca                                                   20


<210> 11142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 11142
cactgaatgg taaacacgat                                                   20


<210> 11143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 11143
aatttttgtg aggcaggagc                                                   20


<210> 11144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 11144
attttttctg ttctgttaga                                                   20


<210> 11145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 11145
tataaaaatg agcagttctc                                                   20


<210> 11146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 11146
tttaacatat tgtcaatgta                                                   20


<210> 11147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 11147
gaagacacaa gatatttaaa                                                   20


<210> 11148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11148
gaagggccag ccataagtaa                                                   20


<210> 11149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 11149
tttagaaata gtaatttaat                                                   20


<210> 11150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 11150
gagtgtattc ttaatattca                                                   20


<210> 11151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11151
acacatcact aaaaataaaa                                                   20


<210> 11152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11152
attatgatgg tatattagag                                                   20


<210> 11153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11153
aagaattata tttttataga                                                   20


<210> 11154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ACGAAT

<400> 11154
gccagcaaat attacaactt                                                   20


<210> 11155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 11155
attaatgtag gtatggctcg                                                   20


<210> 11156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 11156
gtatggctcg cagagtaata                                                   20


<210> 11157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 11157
tatcctgcag ctcattttgc                                                   20


<210> 11158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11158
tagcattatc tacaatgtga                                                   20


<210> 11159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 11159
tcacaatcac ttatgttgaa                                                   20


<210> 11160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 11160
gtgattataa ttctattttg                                                   20


<210> 11161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 11161
cctagtatgg caattatttt                                                   20


<210> 11162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 11162
tgatgcttat agctaaagta                                                   20


<210> 11163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 11163
tcctgatttt aatatgttgt                                                   20


<210> 11164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 11164
taaatattta ctacctacca                                                   20


<210> 11165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 11165
gtcattattt aacattcatg                                                   20


<210> 11166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 11166
ctgtatgata cagaggtagc                                                   20


<210> 11167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11167
gttgaggccc atataggtta                                                   20


<210> 11168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 11168
gaatgtattc agcaaactca                                                   20


<210> 11169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 11169
tcatagggtc atggcttaac                                                   20


<210> 11170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 11170
cccatctgta aaatgagaaa                                                   20


<210> 11171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 11171
gtaatactcc atgtggttgt                                                   20


<210> 11172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 11172
actccatgtg gttgtaaggg                                                   20


<210> 11173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 11173
aaattagaac aatgacaata                                                   20


<210> 11174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11174
aacaatgaca atacagaatc                                                   20


<210> 11175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11175
caatttgcta ctaaaaatgt                                                   20


<210> 11176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 11176
ccctttgcac aaaccttgat                                                   20


<210> 11177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11177
atagatctat gaaatttgta                                                   20


<210> 11178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 11178
ataaaatcat gctaagtatt                                                   20


<210> 11179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 11179
cagtaggaac acttgaagcc                                                   20


<210> 11180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 11180
tacttgggag gctgaggcag                                                   20


<210> 11181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 11181
gcaggagggt tgcttgagcc                                                   20


<210> 11182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 11182
tcatgccatt gcactctagc                                                   20


<210> 11183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 11183
gtaactgcct ttctgtattg                                                   20


<210> 11184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 11184
taatatgaca gtgccttctg                                                   20


<210> 11185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 11185
ttcataatgc agttatattt                                                   20


<210> 11186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 11186
gagtttgaaa taacggtaga                                                   20


<210> 11187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 11187
aggtgatgtt aaattcttaa                                                   20


<210> 11188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11188
agtggttcaa atagcctaag                                                   20


<210> 11189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11189
aatgaaccta agatggtata                                                   20


<210> 11190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 11190
aaagaatctt tagccctaga                                                   20


<210> 11191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ACGGAT

<400> 11191
acaaatgtct caaagtaata                                                   20


<210> 11192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11192
agctcaattt ttgcctgtgc                                                   20


<210> 11193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11193
atgtctacag ctaatgcaaa                                                   20


<210> 11194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 11194
gcaaaatata tttcacatca                                                   20


<210> 11195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11195
tggcaagaga gcaagttggc                                                   20


<210> 11196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CGGGAT

<400> 11196
atttgaaagc ttgccaaaca                                                   20


<210> 11197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 11197
acaactaact gcatatcagg                                                   20


<210> 11198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 11198
atcaactttg cttacagcga                                                   20


<210> 11199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 11199
aaagcaggaa aatttgacaa                                                   20


<210> 11200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 11200
agttatcttt gttttttttg                                                   20


<210> 11201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 11201
tgaggagtgt aatatgtact                                                   20


<210> 11202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 11202
tggttattct atgaacaaaa                                                   20


<210> 11203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 11203
agtcttatcc ttgttggcat                                                   20


<210> 11204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11204
ttgttggcat gtgagtcaag                                                   20


<210> 11205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11205
aatgaaaaac atttgtagaa                                                   20


<210> 11206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 11206
aaattggttc tgatgcaatg                                                   20


<210> 11207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 11207
aatttaagca cctcaaaata                                                   20


<210> 11208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 11208
atttattaaa aaccaaaaaa                                                   20


<210> 11209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 11209
gctataatca ataattccta                                                   20


<210> 11210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11210
gagttctctt acgattctta                                                   20


<210> 11211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 11211
gcccaccttt cttaggaaat                                                   20


<210> 11212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 11212
ttagtgactg cactgccttc                                                   20


<210> 11213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 11213
ttcgagaata ttttgataaa                                                   20


<210> 11214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 11214
tttggcatag acttcctcaa                                                   20


<210> 11215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 11215
catatgaagg tggagaggtg                                                   20


<210> 11216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 11216
ggcatctgtt ttttctggac                                                   20


<210> 11217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 11217
caaaagccat atctttttta                                                   20


<210> 11218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 11218
cggtaacgtc tataagcacg                                                   20


<210> 11219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 11219
tccgttttag tgtggttgtg                                                   20


<210> 11220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 11220
gggttcatag gacactttgg                                                   20


<210> 11221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 11221
ttcttccatc tgtgaacgaa                                                   20


<210> 11222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 11222
gcaaataaga tgtcaagaca                                                   20


<210> 11223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 11223
tggcaatgag ctggactttg                                                   20


<210> 11224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 11224
gggttttgct atgagaagag                                                   20


<210> 11225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 11225
ccagggcagc tgcaaaatca                                                   20


<210> 11226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 11226
agtttagaga actctataaa                                                   20


<210> 11227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CGGGAT

<400> 11227
ctctataaac tgggtcgcat                                                   20


<210> 11228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 11228
acatgttcac cacaaccagg                                                   20


<210> 11229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 11229
tgatgatata actaacaaag                                                   20


<210> 11230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 11230
aaagtagaat attccaacag                                                   20


<210> 11231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 11231
gtctccttca actgaacttc                                                   20


<210> 11232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 11232
acttccagga tgaacttttt                                                   20


<210> 11233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TCGGGT

<400> 11233
gaactttttt tgggtcacag                                                   20


<210> 11234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11234
cagtcgggtg gcttactgtt                                                   20


<210> 11235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GCGGAT

<400> 11235
atcaaagcaa agagcagcgt                                                   20


<210> 11236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 11236
tttgctcctt tgactagacg                                                   20


<210> 11237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ACGGAT

<400> 11237
attcggccaa tcctggcaag                                                   20


<210> 11238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 11238
gcaagacgga tcactcggaa                                                   20


<210> 11239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11239
tatctgtcaa ctcatttctt                                                   20


<210> 11240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CGGAGT

<400> 11240
tttttttttt ttttttgaga                                                   20


<210> 11241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 11241
tctcgctctg tcgcccaggc                                                   20


<210> 11242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CCGGGT

<400> 11242
ctcactgcaa gctccgcctc                                                   20


<210> 11243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CCGAGT

<400> 11243
cattctcctg cctcagcctc                                                   20


<210> 11244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CGGGGT

<400> 11244
ttttgtattt ttagtagaga                                                   20


<210> 11245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 11245
cggggtttca ccttgttagc                                                   20


<210> 11246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 11246
gcctcggcct cccaaagtgc                                                   20


<210> 11247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 11247
gccaagacag ttattttata                                                   20


<210> 11248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 11248
ctgaatgcaa ttacttaaaa                                                   20


<210> 11249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11249
ataatagtgt tttacatttt                                                   20


<210> 11250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 11250
taactattat caatattttt                                                   20


<210> 11251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 11251
tatttattta tttttcaaga                                                   20


<210> 11252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 11252
tcttgctctg tcgccaaagc                                                   20


<210> 11253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CGGGAT

<400> 11253
ctactgcaat ctctgcatcc                                                   20


<210> 11254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 11254
gattctccag cctcagcctc                                                   20


<210> 11255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 11255
acctcggcct cccaatgtgc                                                   20


<210> 11256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11256
tttccatttt tgttactgaa                                                   20


<210> 11257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 11257
agctatgttc tcctaattgc                                                   20


<210> 11258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 11258
taataatatg ttaatagaac                                                   20


<210> 11259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 11259
tgcatatact atatatagta                                                   20


<210> 11260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 11260
cgtatactat atatatagta                                                   20


<210> 11261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 11261
cgtatactat atatatagta                                                   20


<210> 11262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 11262
cgtatactat atatatagta                                                   20


<210> 11263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 11263
cgtatactat atatatagta                                                   20


<210> 11264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 11264
cgtatactat atatatagta                                                   20


<210> 11265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 11265
cgtatactat atatatagta                                                   20


<210> 11266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 11266
cgtatactat atatatagta                                                   20


<210> 11267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 11267
actttacaca ttcaacagta                                                   20


<210> 11268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 11268
gtatttgccc atgtgtctat                                                   20


<210> 11269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11269
ttatgatgat tttttcccca                                                   20


<210> 11270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 11270
ttttgcatag aaaggactat                                                   20


<210> 11271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 11271
tatttccaca tatttcctac                                                   20


<210> 11272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 11272
ctatatgtct taatattttg                                                   20


<210> 11273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11273
tcaccctaat tttcttccag                                                   20


<210> 11274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 11274
aattttcttc cagatgaatt                                                   20


<210> 11275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 11275
aagactcatt gatattttcc                                                   20


<210> 11276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 11276
actttatttt tattgcaatt                                                   20


<210> 11277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 11277
ttgtaccttt tgaactctaa                                                   20


<210> 11278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 11278
atgaagaagg tcattatatt                                                   20


<210> 11279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 11279
tggccaacaa cactaaaaac                                                   20


<210> 11280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 11280
tttttttttc ctgacttaat                                                   20


<210> 11281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 11281
tgacttaata ggaatgcttt                                                   20


<210> 11282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11282
atagaaaaac aaccatggca                                                   20


<210> 11283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 11283
atgaacacca tggctggttg                                                   20


<210> 11284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11284
aacttcactt taaattctgg                                                   20


<210> 11285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 11285
cagatatttg ttttgctttt                                                   20


<210> 11286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 11286
ttcattgtac tgacttactc                                                   20


<210> 11287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11287
tcaagagtaa atttgtgttc                                                   20


<210> 11288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 11288
agcacacatt ctccagtgaa                                                   20


<210> 11289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 11289
actaggtcaa atatacatcc                                                   20


<210> 11290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11290
attttgttct gcaaagaaat                                                   20


<210> 11291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TCGAAT

<400> 11291
gcaaagaaat aagaataata                                                   20


<210> 11292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 11292
aataagaata atatcgaatg                                                   20


<210> 11293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11293
attaaagatg tgcattaaaa                                                   20


<210> 11294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 11294
tattttttta cccctggtcg                                                   20


<210> 11295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 11295
aaaataaatg tagttaaaac                                                   20


<210> 11296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 11296
aattacatat gtgtagaaac                                                   20


<210> 11297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 11297
atatttgtat tacatataat                                                   20


<210> 11298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11298
ttattgctaa gaaaatttgt                                                   20


<210> 11299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11299
atttgtaaga attaaaagta                                                   20


<210> 11300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11300
aaatatttag aacttttata                                                   20


<210> 11301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 11301
aaagaatagg gagccaaatc                                                   20


<210> 11302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 11302
ccattcacaa ttactacaaa                                                   20


<210> 11303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 11303
acaaagagaa taaaatacct                                                   20


<210> 11304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 11304
acctaggaat ccaacttaca                                                   20


<210> 11305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11305
aagaggacac aaacaaatgg                                                   20


<210> 11306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 11306
tggaagaata ttccatgctc                                                   20


<210> 11307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 11307
ccatatgtag aaagttgaaa                                                   20


<210> 11308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 11308
tgtacaaaaa ttaactcaag                                                   20


<210> 11309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 11309
caaaagccaa aacagacaaa                                                   20


<210> 11310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 11310
aaagcaaaag aaactatcat                                                   20


<210> 11311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 11311
cagagtgaac aggcaaccta                                                   20


<210> 11312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 11312
ctgacaaaag ggctaatatc                                                   20


<210> 11313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 11313
actccatcaa aaagtgggca                                                   20


<210> 11314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 11314
agataccacc tcatgccaat                                                   20


<210> 11315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 11315
aggaaacaac agatgttgga                                                   20


<210> 11316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 11316
aacgctttta cactgttggt                                                   20


<210> 11317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11317
agacagtgtg atgattcctc                                                   20


<210> 11318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 11318
ttgacccagc aatctcatta                                                   20


<210> 11319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 11319
cattactggg tatatactca                                                   20


<210> 11320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 11320
aaatgtccat caataataga                                                   20


<210> 11321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 11321
aatgtggcat atatacacca                                                   20


<210> 11322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 11322
aatactatgc agccataaaa                                                   20


<210> 11323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 11323
ctatgcagcc ataaaaaagg                                                   20


<210> 11324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 11324
gcatgttctc actcataagt                                                   20


<210> 11325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGGT

<400> 11325
tcacacacca ggggcagtta                                                   20


<210> 11326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 11326
agggggttgg gagctttggg                                                   20


<210> 11327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 11327
agaaatacct aatgtaaatg                                                   20


<210> 11328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11328
ttaaagtata ataataaaaa                                                   20


<210> 11329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11329
attattcctt tacataaaaa                                                   20


<210> 11330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 11330
taccttttta attctaaata                                                   20


<210> 11331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 11331
atttcaacat aaacacttta                                                   20


<210> 11332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11332
ttagtataat ccatataatt                                                   20


<210> 11333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 11333
ataattaaga atttattttc                                                   20


<210> 11334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 11334
tgagatcatt acttaacttg                                                   20


<210> 11335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 11335
ttacttaact tgtagggtgc                                                   20


<210> 11336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 11336
tatggtttcc ctttattctc                                                   20


<210> 11337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 11337
atttttttaa ttgtttgcta                                                   20


<210> 11338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 11338
atgggaagct tcccattata                                                   20


<210> 11339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 11339
ccagacttcc ctttctgcct                                                   20


<210> 11340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 11340
gttgttgttg ttgtttttga                                                   20


<210> 11341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 11341
tcttgctctg aggcacaggc                                                   20


<210> 11342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 11342
ctcactgcaa cctccacctc                                                   20


<210> 11343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 11343
gtctcagcct cccaagtagc                                                   20


<210> 11344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 11344
ttttgtattt ttagtagaga                                                   20


<210> 11345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 11345
gccttggcct cccaaagtgc                                                   20


<210> 11346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 11346
gccaccatat ccggccacct                                                   20


<210> 11347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11347
tcctggttgt caatatgatg                                                   20


<210> 11348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 11348
gttgtcaata tgatgaagaa                                                   20


<210> 11349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11349
gataaaacta ataggagatt                                                   20


<210> 11350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 11350
aattcaatag agaaacttgc                                                   20


<210> 11351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 11351
ccctttaaaa cctaggtgga                                                   20


<210> 11352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 11352
tcaagtcctt tcttttgtcc                                                   20


<210> 11353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 11353
taaaaccacc tcatcattat                                                   20


<210> 11354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11354
ataaattgag gtaatgcatg                                                   20


<210> 11355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 11355
attaaacttc ctgataagat                                                   20


<210> 11356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 11356
gaggtgaaaa aagtacttat                                                   20


<210> 11357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11357
aaaaagtact tatgaggatg                                                   20


<210> 11358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 11358
agttggaaaa actagtaaaa                                                   20


<210> 11359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 11359
gttggttatt agaaagaggc                                                   20


<210> 11360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 11360
cattgcattg tggaaaagat                                                   20


<210> 11361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 11361
accactttca agggagggag                                                   20


<210> 11362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 11362
tgccattcag tgtgctgcac                                                   20


<210> 11363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TCGGAT

<400> 11363
gtgtcctttg tgacattgtg                                                   20


<210> 11364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11364
tgcaaagcac aaggaacaca                                                   20


<210> 11365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 11365
gaattaggga aacaacaaaa                                                   20


<210> 11366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11366
gatttataaa ttgcctaaaa                                                   20


<210> 11367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 11367
agatgataca tgaacacaat                                                   20


<210> 11368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 11368
tcaaatatca gtaaaaactc                                                   20


<210> 11369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11369
cagtaaaaac tctggaattg                                                   20


<210> 11370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 11370
ttgaactaaa aaactcccta                                                   20


<210> 11371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11371
agacttgatc aaactggaga                                                   20


<210> 11372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 11372
aaaaacaacc ccatcaaaaa                                                   20


<210> 11373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 11373
accccatcaa aaactgggta                                                   20


<210> 11374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 11374
agataccatc tcataccagt                                                   20


<210> 11375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 11375
aggaaacaac aggtgctgga                                                   20


<210> 11376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 11376
agtccgtgtg gcgattcctc                                                   20


<210> 11377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 11377
ttgacccagc catcccatga                                                   20


<210> 11378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 11378
catgactggg tatataccca                                                   20


<210> 11379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 11379
aaatgtccaa caatgataga                                                   20


<210> 11380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 11380
aatatggcac atatacacca                                                   20


<210> 11381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 11381
aatactatgc agccataaaa                                                   20


<210> 11382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 11382
gcactttctc actcataggt                                                   20


<210> 11383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 11383
tcacacacca gggcctgttg                                                   20


<210> 11384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGAT

<400> 11384
ttgtggggtg gggggaggag                                                   20


<210> 11385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 11385
gatataccta atgttaaatg                                                   20


<210> 11386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 11386
taatgttaaa tgatgagtta                                                   20


<210> 11387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 11387
aagaagaaat aaaaaaaaaa                                                   20


<210> 11388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGGT

<400> 11388
aaatcacaga gaagacagaa                                                   20


<210> 11389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11389
atctaaattc aggaaactca                                                   20


<210> 11390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 11390
agcactttga ggggctgagc                                                   20


<210> 11391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 11391
ctttgagggg ctgagcggga                                                   20


<210> 11392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 11392
ggagtggatc acctgaggtc                                                   20


<210> 11393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 11393
ccaaaaatta caaaaatcag                                                   20


<210> 11394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 11394
aaaatcagct gggtgtggtg                                                   20


<210> 11395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 11395
actcgggagg ctgaggcaga                                                   20


<210> 11396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 11396
tgaaagcagc aagaaaaaaa                                                   20


<210> 11397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11397
aaagaaaaaa actgctgacc                                                   20


<210> 11398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 11398
actgtccttt aaaattaagg                                                   20


<210> 11399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 11399
ctcatacaag caaatgctga                                                   20


<210> 11400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 11400
atcttatagg aaatgctaaa                                                   20


<210> 11401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 11401
ggtaaataca tggacaaata                                                   20


<210> 11402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11402
agttaaatgt caaaataatt                                                   20


<210> 11403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11403
gagagaaaaa gacagaaaaa                                                   20


<210> 11404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 11404
aatgattatt tcaaatacaa                                                   20


<210> 11405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 11405
cagtcgtcct tcagtatcta                                                   20


<210> 11406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 11406
gtcatggttt cagaacccca                                                   20


<210> 11407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 11407
ccccaaggga taccaaaatt                                                   20


<210> 11408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 11408
cagtcagtct tgcaggacct                                                   20


<210> 11409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 11409
aaatttgacc ctctgtatct                                                   20


<210> 11410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11410
atctgtggat ttcacattcc                                                   20


<210> 11411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 11411
gtgttttcaa tcagcattgg                                                   20


<210> 11412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 11412
taggtcataa aataagataa                                                   20


<210> 11413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 11413
tataacaatt ataaatatat                                                   20


<210> 11414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 11414
gcaatcattg acagatctga                                                   20


<210> 11415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 11415
atgcagcaac accataacag                                                   20


<210> 11416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 11416
atgaacagaa cagccagata                                                   20


<210> 11417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 11417
atggaatcta taaacaaact                                                   20


<210> 11418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 11418
tgaacaacgc tatagaccaa                                                   20


<210> 11419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 11419
ccaaatggat cacaaacaca                                                   20


<210> 11420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 11420
accatctttt caagtgcgca                                                   20


<210> 11421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 11421
aagtgcgcac agaatattct                                                   20


<210> 11422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 11422
aacactctct tgaaaaagca                                                   20


<210> 11423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 11423
agagctaagt aagtgaaata                                                   20


<210> 11424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11424
tagaaaaagt caacaaaact                                                   20


<210> 11425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 11425
taaaaccaga aatgaaagag                                                   20


<210> 11426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 11426
gaatttacaa ctgattttat                                                   20


<210> 11427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 11427
actgatttta tgggaataag                                                   20


<210> 11428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 11428
aacaattata caccaacaaa                                                   20


<210> 11429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 11429
aacaaattgg ataacttaga                                                   20


<210> 11430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 11430
aaatatacaa cctaccaaga                                                   20


<210> 11431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 11431
aagactgaat catgaggaaa                                                   20


<210> 11432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 11432
atcatgagga aatagaataa                                                   20


<210> 11433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 11433
cgaaagtcat tttatggggc                                                   20


<210> 11434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 11434
aagtgacttc agcaacattg                                                   20


<210> 11435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 11435
aagtaaacat ctacatacac                                                   20


<210> 11436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 11436
cagttctctc cagagaaacc                                                   20


<210> 11437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 11437
cagaaaatac ccatatcaaa                                                   20


<210> 11438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 11438
caaatttgca gctacttccc                                                   20


<210> 11439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 11439
tttctagaaa atgctttttc                                                   20


<210> 11440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 11440
cttttagatc accatgcttg                                                   20


<210> 11441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 11441
gaatggcaga gataagccat                                                   20


<210> 11442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGGT

<400> 11442
ctcaagtaca aaaaacgatg                                                   20


<210> 11443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 11443
ctctcagaag ctttaattcc                                                   20


<210> 11444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11444
ggaaatctac atagcaaatg                                                   20


<210> 11445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 11445
ccttcttcag cctaaacaag                                                   20


<210> 11446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 11446
tttttttttt ttttttgaga                                                   20


<210> 11447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 11447
tctcgctctg tcgcccaggc                                                   20


<210> 11448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CCGGGT

<400> 11448
ctcactgcaa gctccgcctc                                                   20


<210> 11449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CCGAGT

<400> 11449
cattctcctg cctcagcctc                                                   20


<210> 11450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CGGGGT

<400> 11450
ttttgtattt ttagtagaga                                                   20


<210> 11451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 11451
cggggtttca ccgtgttagc                                                   20


<210> 11452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 11452
gcctcggcct cccaaagtgc                                                   20


<210> 11453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 11453
aaatcacatg aaacactctc                                                   20


<210> 11454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TCGAGT

<400> 11454
ttaagaagat taaaatcata                                                   20


<210> 11455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11455
acatgaaact agaagtcaat                                                   20


<210> 11456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 11456
aacatgctcc tgaacaggca                                                   20


<210> 11457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 11457
cggaaaaaca gaaaatattt                                                   20


<210> 11458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 11458
acacaagata acaaatagta                                                   20


<210> 11459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 11459
agagattaga aaaagaagaa                                                   20


<210> 11460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 11460
actgataaca cataaataca                                                   20


<210> 11461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 11461
aacaaccata caccatcaaa                                                   20


<210> 11462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 11462
atcaaattga ataacctaga                                                   20


<210> 11463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 11463
tacatctgaa caaaccaata                                                   20


<210> 11464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 11464
aaaaaaggaa aaggtcactg                                                   20


<210> 11465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11465
attctattta aagaagtaat                                                   20


<210> 11466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 11466
tatactgata tgaaaaccct                                                   20


<210> 11467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 11467
cacaacaata tattagcaaa                                                   20


<210> 11468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 11468
catcattcac catgattact                                                   20


<210> 11469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 11469
gattacttgg gatttatctg                                                   20


<210> 11470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 11470
ctcaacaaag cagatatgga                                                   20


<210> 11471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 11471
tctaagatca ggaacaagac                                                   20


<210> 11472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11472
atttcatgtt catgtgttgg                                                   20


<210> 11473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 11473
atagtaaaaa atcctaacat                                                   20


<210> 11474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 11474
agatatattg gctaatggaa                                                   20


<210> 11475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11475
tgattttcag caaaggtgca                                                   20


<210> 11476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 11476
aataaatggt gttgggaaaa                                                   20


<210> 11477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11477
actgaatatt ccttatgcaa                                                   20


<210> 11478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 11478
tgtatgacat ttatctgggc                                                   20


<210> 11479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 11479
aaaagacaat aagagacaag                                                   20


<210> 11480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 11480
tacagcaaac gaagcaataa                                                   20


<210> 11481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 11481
acagagtgga gagagagatc                                                   20


<210> 11482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 11482
gaaaatcaat aaaccaattg                                                   20


<210> 11483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11483
catttctcaa aagaagagat                                                   20


<210> 11484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 11484
aaatattacc tcacacctcc                                                   20


<210> 11485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11485
gaatggctgt tatcaaaaag                                                   20


<210> 11486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 11486
gaatgataac aagtgttgat                                                   20


<210> 11487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 11487
tatatattta attcctttag                                                   20


<210> 11488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 11488
caacctgtac ccatcaacag                                                   20


<210> 11489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11489
ctgtacccat caacaggtga                                                   20


<210> 11490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11490
attttgtcat tcatcccaac                                                   20


<210> 11491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 11491
gatctcactt acatgtaaaa                                                   20


<210> 11492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 11492
atggggtggg gggagggggg                                                   20


<210> 11493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ACGAGT

<400> 11493
agatatacct aatgtaaatg                                                   20


<210> 11494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 11494
ctaatgtaaa tgacgagtta                                                   20


<210> 11495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 11495
gaaagtataa atcttgatca                                                   20


<210> 11496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 11496
aaggatgtac atttttcatt                                                   20


<210> 11497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 11497
acatttttca tttagagtag                                                   20


<210> 11498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 11498
gtagaggaat aaatcttaag                                                   20


<210> 11499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 11499
caaaaacaaa aattaacaaa                                                   20


<210> 11500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 11500
acagcaaaag aaactatcaa                                                   20


<210> 11501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 11501
cagagtaagc agacagtcta                                                   20


<210> 11502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 11502
tctgacaaag gtctaatatc                                                   20


<210> 11503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 11503
agaatctata aggaacttaa                                                   20


<210> 11504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 11504
accccattaa aaagtgggca                                                   20


<210> 11505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 11505
agataccatc tcacaccagt                                                   20


<210> 11506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 11506
aaaaaataac agatgctggc                                                   20


<210> 11507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11507
ggcgagggtg tggagaaaaa                                                   20


<210> 11508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 11508
aatgcctaca cactgttgat                                                   20


<210> 11509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 11509
tcaacccagc aatcccatta                                                   20


<210> 11510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 11510
tattcacaat ggcaaagaca                                                   20


<210> 11511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 11511
aaatgaccat cagtgataga                                                   20


<210> 11512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11512
atcatatcct ttgcagggac                                                   20


<210> 11513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 11513
tgagaacaca tggacacata                                                   20


<210> 11514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 11514
acacacactg gggcctatgg                                                   20


<210> 11515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 11515
ctggggccta tgggagggtg                                                   20


<210> 11516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 11516
gtgaagggtg ggaggaagga                                                   20


<210> 11517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 11517
gaaaaataac caatgcatac                                                   20


<210> 11518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 11518
catactggga ttaatacctc                                                   20


<210> 11519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11519
gtatatttca aaattgctaa                                                   20


<210> 11520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 11520
ttaccacaaa aaaatgataa                                                   20


<210> 11521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 11521
ttcatcaaaa tattagcaaa                                                   20


<210> 11522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 11522
atcatgtact acgaccaagt                                                   20


<210> 11523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 11523
gaccaagtgg gagttgtccc                                                   20


<210> 11524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 11524
gggagttgtc cctaggatgc                                                   20


<210> 11525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 11525
gatacaccac atgatctgag                                                   20


<210> 11526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 11526
caatttaatt gcaattgtga                                                   20


<210> 11527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 11527
ttaagaggtg tttaagttat                                                   20


<210> 11528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 11528
atgcattaat gctgttatct                                                   20


<210> 11529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 11529
ttaatgctgt tatctcagga                                                   20


<210> 11530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 11530
attctgttat agtagcacaa                                                   20


<210> 11531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 11531
aaaaactttc ctgtaagatc                                                   20


<210> 11532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 11532
agatgacatt attttatatg                                                   20


<210> 11533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 11533
aacaaattta ctagatgttg                                                   20


<210> 11534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 11534
atcaaaagaa ataaaatact                                                   20


<210> 11535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ACGAAT

<400> 11535
aatggaaaga cccagtattc                                                   20


<210> 11536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 11536
catactaccc taagtgatct                                                   20


<210> 11537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 11537
atatggaacc acaaaagact                                                   20


<210> 11538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11538
aagaaaaaag aacaaaatgg                                                   20


<210> 11539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 11539
tctcaccctg ttgcccaggc                                                   20


<210> 11540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 11540
ttcaaatatc ttcgtaaaga                                                   20


<210> 11541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CCGAGT

<400> 11541
gatcctccag ccttagcctc                                                   20


<210> 11542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 11542
gccttagcct cccgagttgc                                                   20


<210> 11543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 11543
aaatatatag gccaatgaaa                                                   20


<210> 11544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGGT

<400> 11544
atagttaact catattcaac                                                   20


<210> 11545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11545
tcatattcaa caggggtgcc                                                   20


<210> 11546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 11546
aacaaataat gttgggaaaa                                                   20


<210> 11547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 11547
tcacatataa aaaaataaaa                                                   20


<210> 11548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 11548
gaaaaaaagg aagcattcaa                                                   20


<210> 11549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 11549
gagggtgaaa aagcaaccta                                                   20


<210> 11550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 11550
cagcactttg ggaggccaag                                                   20


<210> 11551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 11551
actttgggag gccaaggtgg                                                   20


<210> 11552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 11552
tacttgggaa gctgaggcag                                                   20


<210> 11553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 11553
caggagaatc acttgaacca                                                   20


<210> 11554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 11554
actgcactcc agcctggtga                                                   20


<210> 11555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GCGGAT

<400> 11555
actttgggag gccgagacgg                                                   20


<210> 11556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 11556
atcgagacca tcctggctaa                                                   20


<210> 11557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 11557
tacacgggag gctgaggcag                                                   20


<210> 11558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 11558
cccgggaggc ggagcttgca                                                   20


<210> 11559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 11559
agatatcatt tcatacctgc                                                   20


<210> 11560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 11560
aaaagataat aggtgttggc                                                   20


<210> 11561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 11561
ttagaacctt tgtacattgt                                                   20


<210> 11562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 11562
atattttaaa aatttgaact                                                   20


<210> 11563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 11563
aaaatttgaa ctcaggatct                                                   20


<210> 11564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11564
aacaacctaa atgtctattg                                                   20


<210> 11565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 11565
aaatgtctat tgatgaatga                                                   20


<210> 11566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 11566
atcctgccat atgcagcaac                                                   20


<210> 11567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 11567
atgcagcaac ttgaatgaac                                                   20


<210> 11568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 11568
tgaacctgga taaatttatg                                                   20


<210> 11569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11569
aaactcatgg aaacagagag                                                   20


<210> 11570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 11570
tggtgattgc cagggcatga                                                   20


<210> 11571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 11571
gccagggcat gaaaggatgg                                                   20


<210> 11572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 11572
catgaaagga tgggagaatg                                                   20


<210> 11573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 11573
atggagaatt gctattcaat                                                   20


<210> 11574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11574
taaagtttca attatgcaag                                                   20


<210> 11575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 11575
aaattaggaa aggcaaagaa                                                   20


<210> 11576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 11576
tttcatttgt tttttttctt                                                   20


<210> 11577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 11577
gttttttttc tttggaataa                                                   20


<210> 11578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 11578
ttggtcatgt tttttcaggg                                                   20


<210> 11579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11579
attgcaagat gaaatactgg                                                   20


<210> 11580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGAT

<400> 11580
gaaatactgg aagaatgata                                                   20


<210> 11581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 11581
ctggaagaat gataggggat                                                   20


<210> 11582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11582
tcctgcagta gaaatgttgt                                                   20


<210> 11583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 11583
agcaggaaga ttaaagtcaa                                                   20


<210> 11584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 11584
atcctatgca gggaagactg                                                   20


<210> 11585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 11585
acatctgtat ttgtaaatgt                                                   20


<210> 11586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 11586
tgtataggtg gtaccacaac                                                   20


<210> 11587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 11587
agttagttga caagaaactc                                                   20


<210> 11588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 11588
ggtccaggtg gcaggtcaag                                                   20


<210> 11589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 11589
atttttctga gaggttaaat                                                   20


<210> 11590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 11590
tatgttagaa gtattttaca                                                   20


<210> 11591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 11591
acacaggatc tgacatatca                                                   20


<210> 11592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11592
ttcttcccta ctcaacatat                                                   20


<210> 11593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 11593
cgaaagcatt gctatccccc                                                   20


<210> 11594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 11594
tcatttctgt ttcactccat                                                   20


<210> 11595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGAT

<400> 11595
ttatcatgat tatagtattt                                                   20


<210> 11596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 11596
tttggggata gagcatagta                                                   20


<210> 11597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 11597
gagcatagta gagagtttaa                                                   20


<210> 11598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TCGAAT

<400> 11598
ttaatagagt acaagataca                                                   20


<210> 11599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 11599
cacatactcg atatatgacc                                                   20


<210> 11600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 11600
atacttttgt gattgatgtt                                                   20


<210> 11601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 11601
tttgtgattg atgttatggg                                                   20


<210> 11602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 11602
agtcctaacc cttagcactt                                                   20


<210> 11603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 11603
taattaagat gaagtcatac                                                   20


<210> 11604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 11604
aagatgaagt catactggag                                                   20


<210> 11605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 11605
gtcactataa tgggagagat                                                   20


<210> 11606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 11606
aacatggacc tgctgacact                                                   20


<210> 11607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 11607
tctaacctcc aaaagtgtga                                                   20


<210> 11608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 11608
aactacttat aaaatgtgtt                                                   20


<210> 11609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 11609
ataggaaaca ttggaaaaaa                                                   20


<210> 11610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 11610
tgatatattg ctcaaaacct                                                   20


<210> 11611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11611
aaattgtttt ctgtgcaaaa                                                   20


<210> 11612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11612
aagttctaat aaaattaatc                                                   20


<210> 11613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11613
caatgaacaa gttcaaagtg                                                   20


<210> 11614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 11614
agtgctatcc taggtaaaca                                                   20


<210> 11615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CCGAAT

<400> 11615
ccatgtattt tcttttgatt                                                   20


<210> 11616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 11616
ttttgtaaaa atattaccta                                                   20


<210> 11617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 11617
gccctgcttc tattttcttg                                                   20


<210> 11618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 11618
gttgggtcct cacaacacta                                                   20


<210> 11619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 11619
acaacactat ggagtaggca                                                   20


<210> 11620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 11620
cccgaagtca gttgtagagc                                                   20


<210> 11621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 11621
cttggatgat atggtacagc                                                   20


<210> 11622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 11622
tgatatggta cagctagaat                                                   20


<210> 11623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 11623
aaccactagg ctactatcag                                                   20


<210> 11624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 11624
ggatgttctt cattgtctat                                                   20


<210> 11625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 11625
ataatcaata cttacattaa                                                   20


<210> 11626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11626
atcccttaaa agttgccttt                                                   20


<210> 11627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 11627
gcctttaaga ataacattaa                                                   20


<210> 11628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 11628
aagaataaca ttaatagaat                                                   20


<210> 11629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 11629
tattctaaaa tagccataaa                                                   20


<210> 11630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 11630
ctaaattgtt acagttgcct                                                   20


<210> 11631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11631
taaaggtgaa ggaaaatttt                                                   20


<210> 11632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 11632
catcttttct ccatttttta                                                   20


<210> 11633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 11633
gttcattttt gaagcaatat                                                   20


<210> 11634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 11634
atatttgaat ggtgcaagat                                                   20


<210> 11635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 11635
tgggagtcca catgacacca                                                   20


<210> 11636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 11636
tttttttttt tttttgagac                                                   20


<210> 11637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 11637
tctcgctctg tagcccaggc                                                   20


<210> 11638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 11638
gcctcagcct cccaagcagc                                                   20


<210> 11639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 11639
ttttgtattt ttagtagaga                                                   20


<210> 11640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11640
tataattaat atactattta                                                   20


<210> 11641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 11641
acaaatttac tcccatgatg                                                   20


<210> 11642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 11642
ccatgatgct gaatatcagc                                                   20


<210> 11643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 11643
agtagcacat tcatgatgga                                                   20


<210> 11644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 11644
tgatggaagg aattgctcct                                                   20


<210> 11645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 11645
aaaagaaaga aaagcatgat                                                   20


<210> 11646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 11646
attggtgtat atcaggtagg                                                   20


<210> 11647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 11647
ttttgagaca ttctccacaa                                                   20


<210> 11648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 11648
acattctcca caaaaggatt                                                   20


<210> 11649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 11649
acctgttagg gaaggagcac                                                   20


<210> 11650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 11650
ctttaaaata gagaaatact                                                   20


<210> 11651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 11651
tataaatatt tttaggcttt                                                   20


<210> 11652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 11652
tcaactctgc catggtagtc                                                   20


<210> 11653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 11653
acatttttac aaaaacaggc                                                   20


<210> 11654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 11654
ggtccagagc aatgattatt                                                   20


<210> 11655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 11655
tgacctcaaa aaagattagg                                                   20


<210> 11656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 11656
caaaaaagat taggaggaat                                                   20


<210> 11657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 11657
gattaggagg aataggaata                                                   20


<210> 11658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 11658
taccatgtgg tatcactgcc                                                   20


<210> 11659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CCGGAT

<400> 11659
tgatgtcttc ccagacttcc                                                   20


<210> 11660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CGGGGT

<400> 11660
cctactcact ctttggggac                                                   20


<210> 11661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 11661
aaaatgtttt tctaaaaaat                                                   20


<210> 11662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 11662
ctaaaaaatg tgagtaatga                                                   20


<210> 11663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 11663
atgtgagtaa tgatggaatc                                                   20


<210> 11664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11664
cttcaaaata gccctgcggc                                                   20


<210> 11665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 11665
gataaagaac aaagagcaaa                                                   20


<210> 11666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11666
aaaaaattaa gttaatgtca                                                   20


<210> 11667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 11667
tgtaattttc aacttgtaga                                                   20


<210> 11668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 11668
aacttgtaga tagaatattt                                                   20


<210> 11669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 11669
tacttggaaa ccgttataca                                                   20


<210> 11670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 11670
gcagtcataa ttaggtttgt                                                   20


<210> 11671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 11671
caagtttctt atccccatcc                                                   20


<210> 11672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 11672
agtttctgac tcagtaggtc                                                   20


<210> 11673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11673
gtaggtctgg ggtgagatcc                                                   20


<210> 11674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 11674
tttttttttt ttttttgata                                                   20


<210> 11675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 11675
tcttgctctg ttccccaggc                                                   20


<210> 11676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CCGGGT

<400> 11676
ctcactgcaa cctctgcctc                                                   20


<210> 11677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CCGGGT

<400> 11677
acaggtgagc accactatgc                                                   20


<210> 11678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 11678
ttttgcattt ttagtagaga                                                   20


<210> 11679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 11679
taagtaaaat acaatataat                                                   20


<210> 11680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 11680
tttaggtgtc tgaacagaga                                                   20


<210> 11681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ACGGGT

<400> 11681
ggtgtttgtc tgctatacaa                                                   20


<210> 11682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 11682
tgtctgctat acaaacgggt                                                   20


<210> 11683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 11683
atctggagaa gaaattttag                                                   20


<210> 11684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 11684
ttagaggagt accaacacat                                                   20


<210> 11685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 11685
tatggactaa ttacagaaaa                                                   20


<210> 11686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 11686
aacttgtttg tctctgctaa                                                   20


<210> 11687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 11687
atatgaaaaa agtcactcat                                                   20


<210> 11688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 11688
ttgacaatat tagataaagg                                                   20


<210> 11689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 11689
tatatatata tagagagaga                                                   20


<210> 11690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 11690
taatatacta gtatatacta                                                   20


<210> 11691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 11691
ttaaagctct cagtgtccga                                                   20


<210> 11692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 11692
ggatttaatg gggccaagat                                                   20


<210> 11693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 11693
gggccaagat ctgagtagcc                                                   20


<210> 11694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CGGAGT

<400> 11694
gaacaataag atggtatata                                                   20


<210> 11695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 11695
gtgtagtcaa tgcctaaaaa                                                   20


<210> 11696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 11696
atgcctaaaa atagggtaag                                                   20


<210> 11697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 11697
aagtaagttg tttattctat                                                   20


<210> 11698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 11698
cattttgaag actcatgatt                                                   20


<210> 11699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 11699
aatcacaatt gtactgaaga                                                   20


<210> 11700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 11700
aattgtactg aagagagaat                                                   20


<210> 11701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 11701
aaccagtatc caaaagaaat                                                   20


<210> 11702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 11702
gctcctccat gaccttagat                                                   20


<210> 11703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 11703
tctataaata tgtttactct                                                   20


<210> 11704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 11704
cgatgtctaa gaaaaatgtc                                                   20


<210> 11705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ACGAAT

<400> 11705
ctggaatgca gttcttcatt                                                   20


<210> 11706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11706
gagattcaat ttttcgaggg                                                   20


<210> 11707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 11707
tcctaaagct acgtatttag                                                   20


<210> 11708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 11708
ttttaatgtt ttgctgtggt                                                   20


<210> 11709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11709
gtcatgaagg ttctgccttc                                                   20


<210> 11710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 11710
gaaggttctg ccttcatgaa                                                   20


<210> 11711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 11711
ctgccttcat gaatggaata                                                   20


<210> 11712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 11712
gaatatagag taagggctta                                                   20


<210> 11713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 11713
agggcttaat gggttatcat                                                   20


<210> 11714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 11714
cttaatgggt tatcatggga                                                   20


<210> 11715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 11715
gggagtgagt tagatatcac                                                   20


<210> 11716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 11716
gtgagttaga tatcacaaga                                                   20


<210> 11717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 11717
ttaagaaata aatttcttta                                                   20


<210> 11718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 11718
gttctccaag ccactgttaa                                                   20


<210> 11719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CGGAAT

<400> 11719
gttaagtgag ttttatgaca                                                   20


<210> 11720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 11720
ctatggtata gtttgtaact                                                   20


<210> 11721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 11721
aaatcagaca agtccattct                                                   20


<210> 11722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 11722
aatataagta gttctgaaat                                                   20


<210> 11723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 11723
tctgaaatct gaatatacaa                                                   20


<210> 11724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 11724
tgatttgcca catccaaccc                                                   20


<210> 11725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 11725
gtttctgatt cagtatgtct                                                   20


<210> 11726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 11726
gtatgtcttg gggttggggg                                                   20


<210> 11727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 11727
gggcagaatt tgcatctctt                                                   20


<210> 11728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11728
aaatttgcat ctctgtcagc                                                   20


<210> 11729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 11729
tattaaataa tatttcaaat                                                   20


<210> 11730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 11730
aacaggaggt tatactcact                                                   20


<210> 11731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 11731
gtaaaccttc atttcttaca                                                   20


<210> 11732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 11732
tcttacactg aatgatgaaa                                                   20


<210> 11733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11733
gtaactagat aacttgatat                                                   20


<210> 11734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 11734
atcattacta tatccgaagt                                                   20


<210> 11735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 11735
tattattatt ttttttgaga                                                   20


<210> 11736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 11736
tctcaccctg tcgcccaagc                                                   20


<210> 11737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CCGGGT

<400> 11737
ctcactgaaa cctctgccta                                                   20


<210> 11738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 11738
gattcttctg cctcagcctc                                                   20


<210> 11739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 11739
gcctcagcct cctgagtagc                                                   20


<210> 11740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CGGGGT

<400> 11740
tttgtatttt ttagtagaga                                                   20


<210> 11741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 11741
gcctcggact ctcaaagtgc                                                   20


<210> 11742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 11742
agccaaaagt ttatgaagct                                                   20


<210> 11743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 11743
acagttgaga aattgaactt                                                   20


<210> 11744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11744
taatccacat atgatgctgt                                                   20


<210> 11745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 11745
ctaaaaacta tgactgatta                                                   20


<210> 11746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11746
ttaggtttct gaaaatctag                                                   20


<210> 11747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 11747
ttattaaaat ataaaataat                                                   20


<210> 11748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 11748
cattcaatga aatgataata                                                   20


<210> 11749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 11749
tgtaccgtta gtttctattt                                                   20


<210> 11750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11750
ttaaaataat atgtaaacta                                                   20


<210> 11751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 11751
tccaagtatt caacagttct                                                   20


<210> 11752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 11752
cattttggtt tttcctataa                                                   20


<210> 11753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11753
ttatcttcca attttacatt                                                   20


<210> 11754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11754
aattttgttt tattcttaac                                                   20


<210> 11755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11755
ggctgtgtta atatttctaa                                                   20


<210> 11756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11756
gttttttcac aacacacagt                                                   20


<210> 11757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 11757
atccatttta gaagcatttc                                                   20


<210> 11758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 11758
aagatcttgt ctgcatactc                                                   20


<210> 11759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11759
gaggtcaaga gaaagtgcaa                                                   20


<210> 11760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 11760
ctcctctttc tccattaaaa                                                   20


<210> 11761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 11761
ctcccctttt tccccaccag                                                   20


<210> 11762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11762
ggaaaggaaa gatttgctaa                                                   20


<210> 11763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 11763
taataggcct atagaacaca                                                   20


<210> 11764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 11764
gccacaacac agtgaaagga                                                   20


<210> 11765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11765
cagccacatg tcccttgaca                                                   20


<210> 11766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 11766
tcgaaacact attaaccctg                                                   20


<210> 11767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 11767
gacaagttgg ggcagaaaga                                                   20


<210> 11768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 11768
gcagaggttc tgaaattcaa                                                   20


<210> 11769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 11769
agagggaggc ttctagccct                                                   20


<210> 11770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 11770
actccacccc caaattctgg                                                   20


<210> 11771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 11771
ctgtttctag aactggtgta                                                   20


<210> 11772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 11772
tctctgactg gtcccagagc                                                   20


<210> 11773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 11773
actggtccca gagcaggaat                                                   20


<210> 11774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGGT

<400> 11774
ggaattagaa ttcagcccac                                                   20


<210> 11775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 11775
tagcttccag aaccaatttt                                                   20


<210> 11776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11776
ggatgtagga gcaaggaggc                                                   20


<210> 11777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 11777
agcaaaatat cataatctca                                                   20


<210> 11778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 11778
ttaactttta ttttaggttt                                                   20


<210> 11779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGGT

<400> 11779
cataggtaaa cacgtgtcat                                                   20


<210> 11780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 11780
tttatttaaa atacactttt                                                   20


<210> 11781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 11781
tgttttagac attttgaaca                                                   20


<210> 11782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 11782
tgaaattctc agtcacatat                                                   20


<210> 11783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 11783
gtcacatatg tgagtcagca                                                   20


<210> 11784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 11784
gataaacctc cttagttact                                                   20


<210> 11785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 11785
gacactatca tgatttctac                                                   20


<210> 11786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 11786
tgatcacatt ttctgtttct                                                   20


<210> 11787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 11787
gataggaaag gaaagccaca                                                   20


<210> 11788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 11788
tgggtccctg caggttgttg                                                   20


<210> 11789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11789
aggttgttgg ggagtgtgcc                                                   20


<210> 11790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 11790
tccttaccta ggacattcct                                                   20


<210> 11791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 11791
agcaaccttg agacatgagg                                                   20


<210> 11792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 11792
agggtctctg ggacaaagag                                                   20


<210> 11793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 11793
gcttatgttg cttggtataa                                                   20


<210> 11794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 11794
atataatgcc cccatgagac                                                   20


<210> 11795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 11795
tgaggcaagt tacaaagttc                                                   20


<210> 11796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11796
gaagctgctt gtatgtgtac                                                   20


<210> 11797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 11797
gttcagcagt ttttaatttc                                                   20


<210> 11798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11798
tccattgctc tgagctcctt                                                   20


<210> 11799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 11799
tccttaagaa taaacagtac                                                   20


<210> 11800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 11800
gtgaaagttg atcatacaaa                                                   20


<210> 11801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 11801
tactcaacta acagtcaact                                                   20


<210> 11802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 11802
aaggcagggg gaaaagctct                                                   20


<210> 11803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11803
agggtacaaa acattactcc                                                   20


<210> 11804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 11804
ctcttttcta ttatagccat                                                   20


<210> 11805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 11805
acaacagcat tcagggcagc                                                   20


<210> 11806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 11806
aaggataatg cctggcatgt                                                   20


<210> 11807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 11807
ttgtcattgg cactaatcat                                                   20


<210> 11808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11808
ttatctttta gctcatttta                                                   20


<210> 11809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 11809
accagggcac cactgctgag                                                   20


<210> 11810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 11810
gcatgttaaa tcttgatatt                                                   20


<210> 11811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 11811
caatttcaga tagatttaat                                                   20


<210> 11812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 11812
aaaccacttt cattttatgt                                                   20


<210> 11813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11813
cactttcatt ttatgtgtga                                                   20


<210> 11814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11814
ttcattttat gtgtgaatga                                                   20


<210> 11815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11815
aactaaaatc tgaagacgac                                                   20


<210> 11816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 11816
tctgaagacg acatgaattt                                                   20


<210> 11817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 11817
tacatgattt cctttcctca                                                   20


<210> 11818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 11818
caactaaagt gacagatagt                                                   20


<210> 11819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 11819
cttcctagaa gagatggagc                                                   20


<210> 11820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 11820
tagaagagat ggagcctggg                                                   20


<210> 11821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 11821
gaatcaaaat atcagtaaaa                                                   20


<210> 11822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 11822
aaatatcagt aaaaaagagt                                                   20


<210> 11823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 11823
tcagtaaaaa agagtttggg                                                   20


<210> 11824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 11824
catagaaatt taaaccagtt                                                   20


<210> 11825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 11825
gtttagaatt gtgatgcaag                                                   20


<210> 11826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 11826
gcagaatgta cacaagaggc                                                   20


<210> 11827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 11827
aagcattggc ctttacctta                                                   20


<210> 11828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 11828
cttatatcct attgaggttg                                                   20


<210> 11829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 11829
ttgaggttga ggagtaagta                                                   20


<210> 11830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 11830
agatgtctcc acggtacatg                                                   20


<210> 11831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 11831
gtacatggag gataagttgg                                                   20


<210> 11832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 11832
atggaggata agttggaagg                                                   20


<210> 11833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 11833
agttggaagg gtgaatagag                                                   20


<210> 11834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGGT

<400> 11834
aagggtgaat agagaggagt                                                   20


<210> 11835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 11835
tttcataccc agaaaaccat                                                   20


<210> 11836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 11836
gggaaagatt agttaggaac                                                   20


<210> 11837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 11837
tatttggcag ataaaatcag                                                   20


<210> 11838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 11838
cagcaggatt tggtgattga                                                   20


<210> 11839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 11839
tatcaaatgt aagagaaagg                                                   20


<210> 11840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 11840
aaggatccca ggactaccag                                                   20


<210> 11841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 11841
ctaccaggtg gatgttagca                                                   20


<210> 11842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 11842
gtaatgattt tgagatgcct                                                   20


<210> 11843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGGT

<400> 11843
atcctataga ttttaaaaat                                                   20


<210> 11844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11844
cgggaaaaac ctgtctagaa                                                   20


<210> 11845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 11845
agtttttgag gtcacacaaa                                                   20


<210> 11846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 11846
ggtcacacaa aaagagtatt                                                   20


<210> 11847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 11847
gaaacaacaa tattaaggga                                                   20


<210> 11848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 11848
aatatttgac tatataaact                                                   20


<210> 11849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 11849
attttatttg tctattccgt                                                   20


<210> 11850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 11850
tggacggtgg tctattctct                                                   20


<210> 11851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 11851
ctactgtgca actcttcttt                                                   20


<210> 11852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 11852
ttctatctgg cctattctat                                                   20


<210> 11853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 11853
tgtcacactg ttgagctact                                                   20


<210> 11854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 11854
agtttgaaat cagtgatggt                                                   20


<210> 11855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 11855
atgagagctt cttgattttc                                                   20


<210> 11856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 11856
agcttcttga ttttctagag                                                   20


<210> 11857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 11857
ttgtgtttgt agccattact                                                   20


<210> 11858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11858
aataattgct tacatcactg                                                   20


<210> 11859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 11859
attgcttaca tcactgatga                                                   20


<210> 11860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 11860
ttgagaaaca atttgatata                                                   20


<210> 11861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 11861
agatgaacaa gaaggaccaa                                                   20


<210> 11862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 11862
gtgcagtaaa agagaaacca                                                   20


<210> 11863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 11863
gaacataaga ggcccagaaa                                                   20


<210> 11864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 11864
ttaaagttta ttaaagcaac                                                   20


<210> 11865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 11865
ctctttaaaa agtaactaca                                                   20


<210> 11866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11866
aaggcaggag gtgggaaagt                                                   20


<210> 11867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 11867
ttgatacctg tttcagaagt                                                   20


<210> 11868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 11868
atataattca ttaacaagta                                                   20


<210> 11869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 11869
atgttctaaa acaacaaaac                                                   20


<210> 11870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11870
ctggtagaaa atgttttgta                                                   20


<210> 11871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 11871
aagttcccag aagactcaaa                                                   20


<210> 11872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 11872
aaaagacttg attccccaaa                                                   20


<210> 11873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 11873
atttgaaagg ttacatctct                                                   20


<210> 11874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 11874
ttctatactt tacataaaca                                                   20


<210> 11875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 11875
gatgaaaaag aaaaaaaaag                                                   20


<210> 11876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 11876
tcgataaaat gatataaaaa                                                   20


<210> 11877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 11877
atgatataaa aacagagtaa                                                   20


<210> 11878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 11878
ataaaaacag agtaaaaggg                                                   20


<210> 11879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11879
gagagagcga aaaaaatgag                                                   20


<210> 11880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 11880
ttaatattaa cttagtgctt                                                   20


<210> 11881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11881
aacaatgatc acatataaga                                                   20


<210> 11882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 11882
tctttctcag gggcaaatta                                                   20


<210> 11883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 11883
gttaagaaga ttttgctctc                                                   20


<210> 11884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 11884
agtttcataa atattgccct                                                   20


<210> 11885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 11885
tcagggttta ttacacctca                                                   20


<210> 11886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 11886
tctttctctt attttgaggc                                                   20


<210> 11887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 11887
ctctttaaaa ggactattaa                                                   20


<210> 11888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 11888
aattgaatgt aaacataaca                                                   20


<210> 11889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 11889
agaatctctc aaacatttta                                                   20


<210> 11890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 11890
aaacatttta atgggtccca                                                   20


<210> 11891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 11891
gtgagtaaat gctatttctt                                                   20


<210> 11892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 11892
tgcattacat aaagtctatg                                                   20


<210> 11893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 11893
agaaaaaata aaagtcacaa                                                   20


<210> 11894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 11894
ggttattgtg ttactaaagt                                                   20


<210> 11895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGGT

<400> 11895
tattagttat tttataggaa                                                   20


<210> 11896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 11896
agttatttta taggaagggg                                                   20


<210> 11897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 11897
accattatta ttttttgaga                                                   20


<210> 11898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 11898
gtctcacttt gttgccaggc                                                   20


<210> 11899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 11899
gccaggctgg agtgcagtag                                                   20


<210> 11900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 11900
ctcactgcaa cctctgcctc                                                   20


<210> 11901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 11901
gattctcctg cctcagcctc                                                   20


<210> 11902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CGGGAT

<400> 11902
ttttgtattt ttagtagaaa                                                   20


<210> 11903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 11903
cgggatttca ccatgttagc                                                   20


<210> 11904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 11904
tataaaacca catagaccca                                                   20


<210> 11905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 11905
ttgccaagtc atgtagaact                                                   20


<210> 11906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 11906
gcataagagg gagagaaaag                                                   20


<210> 11907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11907
gtgataatta tgaagctgaa                                                   20


<210> 11908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 11908
cttcagtaaa aacatgctac                                                   20


<210> 11909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 11909
aagctcccat cacctctcac                                                   20


<210> 11910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 11910
atttgtttgt ttgttggaga                                                   20


<210> 11911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 11911
tcttcctctg tcgtccaggc                                                   20


<210> 11912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 11912
ctcactgcaa cctctgcctc                                                   20


<210> 11913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 11913
gcctcagcct cacaagtagc                                                   20


<210> 11914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 11914
tttttcattt tcagtaaaaa                                                   20


<210> 11915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 11915
acctcggcct cccaaagtac                                                   20


<210> 11916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGGT

<400> 11916
cttgatatgt ttcttcagca                                                   20


<210> 11917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 11917
tttaataatt atttgtttac                                                   20


<210> 11918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11918
attatttgtt tactggaata                                                   20


<210> 11919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 11919
ctggaataaa gaatgattat                                                   20


<210> 11920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 11920
taagcaaatt ggctgcttca                                                   20


<210> 11921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 11921
tctctgctgg agcacataaa                                                   20


<210> 11922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11922
ctggcctcag tttggaagca                                                   20


<210> 11923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 11923
ttggaagcaa tgaataatct                                                   20


<210> 11924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 11924
agtattttca ttgatgttta                                                   20


<210> 11925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 11925
atagtattaa tactttctgt                                                   20


<210> 11926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 11926
caacttcttt ctagttatcc                                                   20


<210> 11927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11927
aagtcatgat cattcataaa                                                   20


<210> 11928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 11928
aagcacaaaa tttatattga                                                   20


<210> 11929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11929
ccaatcattt tgcttaaccc                                                   20


<210> 11930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 11930
tttcaaaaaa tactaatgct                                                   20


<210> 11931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 11931
cttctgtata agattgttaa                                                   20


<210> 11932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11932
gattgttaac agaatccttg                                                   20


<210> 11933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 11933
cctcttagca tcgctgtgat                                                   20


<210> 11934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 11934
cagcatatca gaaagcatac                                                   20


<210> 11935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 11935
cagactttac cctagaggcc                                                   20


<210> 11936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 11936
aagggcttgg gccctatctc                                                   20


<210> 11937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 11937
tgactagcaa ggaaaacttt                                                   20


<210> 11938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 11938
tctctcaaag tctttagctt                                                   20


<210> 11939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 11939
aaaaaaaaac ttattaaact                                                   20


<210> 11940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 11940
acagatggtg atgaccaatg                                                   20


<210> 11941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 11941
tgtaagcaga tctgggactc                                                   20


<210> 11942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 11942
gaggtaaaga cattgatgtt                                                   20


<210> 11943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 11943
catgaaacac ctcagagctt                                                   20


<210> 11944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 11944
tggggagaaa tcattattta                                                   20


<210> 11945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11945
cctctgaaac taaggaaagg                                                   20


<210> 11946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 11946
acagtatcaa acagttttct                                                   20


<210> 11947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 11947
aaacagtttt ctgagagtta                                                   20


<210> 11948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 11948
ccatttttga ttaaaaggac                                                   20


<210> 11949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 11949
tctggtggtt ccattgatct                                                   20


<210> 11950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ACGAAT

<400> 11950
ggttccattg atctgggaat                                                   20


<210> 11951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 11951
taatcatcat acagctatag                                                   20


<210> 11952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 11952
cagctatagc tgaatcagca                                                   20


<210> 11953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 11953
atagctgaat cagcatggaa                                                   20


<210> 11954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 11954
aaaccccaga acactaatta                                                   20


<210> 11955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CGGAAT

<400> 11955
gaaacaggcc tctggctcat                                                   20


<210> 11956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 11956
ttcttctcct tctccaggca                                                   20


<210> 11957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 11957
gaccggttta atctctagaa                                                   20


<210> 11958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 11958
accccaccag gtagttcatt                                                   20


<210> 11959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 11959
aatgtatttt ttattatctc                                                   20


<210> 11960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 11960
ttgaatttaa atatatgtag                                                   20


<210> 11961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 11961
aaacatggca gacttacaca                                                   20


<210> 11962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11962
gcagacttac acatggaata                                                   20


<210> 11963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 11963
tttttctcac ccagagcttt                                                   20


<210> 11964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 11964
tcccaaatat tgttttataa                                                   20


<210> 11965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 11965
gtaaagcagc atatcaatgg                                                   20


<210> 11966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 11966
tctcatttgc taaatgacat                                                   20


<210> 11967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 11967
agttacaact ttatcttttt                                                   20


<210> 11968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 11968
gataaattga ttctcaatct                                                   20


<210> 11969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 11969
ggaagctaga agtattcttg                                                   20


<210> 11970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 11970
tacaacatca taaaaatggc                                                   20


<210> 11971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 11971
tggataaagt attgtacata                                                   20


<210> 11972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 11972
gacaatgtct ttcttataac                                                   20


<210> 11973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 11973
gcattattcc caccaggtcc                                                   20


<210> 11974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 11974
aaacatgtta tttaaactga                                                   20


<210> 11975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 11975
ataatagaaa ttaattataa                                                   20


<210> 11976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 11976
ctgaatattc tataaaacta                                                   20


<210> 11977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 11977
aggctttaaa gtataaacta                                                   20


<210> 11978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 11978
tttaaagtat aaactataga                                                   20


<210> 11979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 11979
gattaatcca ggaaacgatg                                                   20


<210> 11980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11980
aggcccttca tttctgaaaa                                                   20


<210> 11981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 11981
ctgaaaaaag aattattggc                                                   20


<210> 11982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 11982
ttttgaggta aagcagtgag                                                   20


<210> 11983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11983
tgagaggaat tgctgataga                                                   20


<210> 11984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 11984
aataaaatga ttcttatttg                                                   20


<210> 11985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 11985
tatgtttttt taatggtcaa                                                   20


<210> 11986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 11986
caattgaatt cagcttggca                                                   20


<210> 11987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 11987
tagacattca atgttttctt                                                   20


<210> 11988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 11988
cttctttagc agatttctaa                                                   20


<210> 11989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 11989
ttttcctgcg gtgaaatata                                                   20


<210> 11990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 11990
catcaccata tttaagtact                                                   20


<210> 11991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 11991
ccatgtaatt ttggaaatga                                                   20


<210> 11992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 11992
ggaccttctg taattttcac                                                   20


<210> 11993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 11993
agtaaatata aatataagca                                                   20


<210> 11994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 11994
aaggtggact cactagtatt                                                   20


<210> 11995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 11995
ttagcattcc tgccttttta                                                   20


<210> 11996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 11996
tgtgttttct actatactgc                                                   20


<210> 11997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 11997
taagcctatt tcatgctatc                                                   20


<210> 11998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 11998
tgttccaaga ggtgtgaggt                                                   20


<210> 11999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 11999
caacaaaaac cttactcaaa                                                   20


<210> 12000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12000
attctttaag gagcagagcc                                                   20


<210> 12001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 12001
aagcaaatca aaaggaggag                                                   20


<210> 12002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 12002
caatatctat aattgtgttc                                                   20


<210> 12003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 12003
attgtgttct tgaatcatta                                                   20


<210> 12004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 12004
aaaatagtaa atttcaatta                                                   20


<210> 12005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 12005
aaatttcaat taaaggatca                                                   20


<210> 12006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 12006
acatagttac tatgtggcat                                                   20


<210> 12007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 12007
atgtgaacat tatcctctta                                                   20


<210> 12008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 12008
tactattagt gcttttcatc                                                   20


<210> 12009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 12009
ttaaaaaatc actgaagctc                                                   20


<210> 12010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 12010
aatattgtgt aggctctggg                                                   20


<210> 12011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 12011
cagccaccac cagagaaatt                                                   20


<210> 12012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 12012
cggagacctc ttctttttct                                                   20


<210> 12013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12013
acgtgactaa atgataagat                                                   20


<210> 12014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 12014
aagaagagaa gcaaagagct                                                   20


<210> 12015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 12015
ctgtttgcag agaaagcagc                                                   20


<210> 12016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 12016
gagaaagcag ctggaataca                                                   20


<210> 12017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 12017
tggaatacag tgggtcaagt                                                   20


<210> 12018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 12018
aatgcaacaa gtaggtaaag                                                   20


<210> 12019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12019
tctataattt tgaaacaaac                                                   20


<210> 12020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12020
aaagtaagct acctagatat                                                   20


<210> 12021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 12021
atgaaggagg gcaaggaaaa                                                   20


<210> 12022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12022
gcaaggaaaa gtgaatttta                                                   20


<210> 12023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 12023
gaaaagtgaa ttttaatgaa                                                   20


<210> 12024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 12024
attactagct ttttaaacat                                                   20


<210> 12025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 12025
aatataaata gaaattttac                                                   20


<210> 12026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12026
atatttcaag tcattcttaa                                                   20


<210> 12027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 12027
atattcagtt tttttcttaa                                                   20


<210> 12028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12028
cagcttggta aaaaagtaat                                                   20


<210> 12029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12029
taaaaaagta ataagaattt                                                   20


<210> 12030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 12030
ctatacctat atagataata                                                   20


<210> 12031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 12031
gaagaaaatt caccatattc                                                   20


<210> 12032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 12032
ggaataaaat agttttctat                                                   20


<210> 12033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 12033
tctctaaggt gtgtcaattt                                                   20


<210> 12034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 12034
atatgaacta gattataaaa                                                   20


<210> 12035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 12035
ttctatgtgt tattgataga                                                   20


<210> 12036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 12036
tcagaaactt attcttatca                                                   20


<210> 12037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 12037
tcaatgagta atattacttc                                                   20


<210> 12038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 12038
ataaaatcaa atgttaatta                                                   20


<210> 12039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 12039
ttcaaagttt atactagaag                                                   20


<210> 12040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 12040
tagatgtgta ctaagaaagc                                                   20


<210> 12041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 12041
cttatccata aatacataac                                                   20


<210> 12042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12042
agaattatta aatacaaagc                                                   20


<210> 12043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 12043
acacttcttc cacaattttt                                                   20


<210> 12044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 12044
ttacatcaag aagtcatcaa                                                   20


<210> 12045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 12045
tatgtttcta ctttcttgca                                                   20


<210> 12046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12046
tgtgagaaga aggttaggta                                                   20


<210> 12047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 12047
ttagaaatgc agcatgatga                                                   20


<210> 12048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 12048
ctcaacgtta agcaatatat                                                   20


<210> 12049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 12049
tctactctac tatttaaaaa                                                   20


<210> 12050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGGT

<400> 12050
tataagtgat tctcagtata                                                   20


<210> 12051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 12051
atagggggtg aggtggcagt                                                   20


<210> 12052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12052
tccaaattta tcaaaatata                                                   20


<210> 12053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 12053
aaagaataag acacattgat                                                   20


<210> 12054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 12054
gtctaagtgc aattctacag                                                   20


<210> 12055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12055
aaaaatctat gcataaaata                                                   20


<210> 12056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12056
atgactttgt aaactgaaca                                                   20


<210> 12057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12057
gtaaactgaa cactgaatag                                                   20


<210> 12058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 12058
actgaacact gaatagatga                                                   20


<210> 12059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 12059
aacactgaat agatgaatgg                                                   20


<210> 12060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12060
atagatgaat gggtggatag                                                   20


<210> 12061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12061
atgaatgggt ggatagatga                                                   20


<210> 12062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 12062
atgggtggat agatgaatga                                                   20


<210> 12063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 12063
gtggatagat gaatgaatga                                                   20


<210> 12064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12064
gagtgaatca ggtgaacaat                                                   20


<210> 12065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ACGGAT

<400> 12065
gactagttta gtgtcctgtt                                                   20


<210> 12066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 12066
ttacctaagg tgcaagctat                                                   20


<210> 12067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 12067
tagggggcca aaaatatttc                                                   20


<210> 12068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 12068
gcctattata attctgggca                                                   20


<210> 12069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12069
actatgcaca aataaaagaa                                                   20


<210> 12070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12070
aagaaataag attatacagg                                                   20


<210> 12071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 12071
tttttgcaga ttaaaaatgg                                                   20


<210> 12072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 12072
ttcttttgac attttcataa                                                   20


<210> 12073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 12073
cttccaaggt atcttaccaa                                                   20


<210> 12074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 12074
aagagaatcc agattttatt                                                   20


<210> 12075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGGT

<400> 12075
agccaggcta ccttgttgtt                                                   20


<210> 12076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 12076
caataagaca taagccaaag                                                   20


<210> 12077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 12077
gacataagcc aaagttggat                                                   20


<210> 12078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 12078
tttgcccttc ctcaggcaag                                                   20


<210> 12079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 12079
cgttctattt ctttctctac                                                   20


<210> 12080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 12080
tttctttctc tacctgggta                                                   20


<210> 12081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 12081
gccacgtgga ctgctgatct                                                   20


<210> 12082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 12082
gatgttttaa aatatgaaaa                                                   20


<210> 12083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 12083
ctctgttgca tgcagttaaa                                                   20


<210> 12084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 12084
aaacacacac acaaaaaaat                                                   20


<210> 12085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 12085
tctggacttt agtgatattt                                                   20


<210> 12086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 12086
catcaacaag ccagggagag                                                   20


<210> 12087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12087
agcaaggttt tcacctagag                                                   20


<210> 12088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12088
aggttttcac ctagagaaga                                                   20


<210> 12089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 12089
caggcagaag ctacaagaac                                                   20


<210> 12090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 12090
agaacttgaa tttggtctag                                                   20


<210> 12091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12091
tataaaatat gcatttaata                                                   20


<210> 12092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 12092
tactgaataa atggaaagga                                                   20


<210> 12093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 12093
ttttactttt caataaagaa                                                   20


<210> 12094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 12094
cctaatcagt cagcattaag                                                   20


<210> 12095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 12095
gtggattaga agcacaatat                                                   20


<210> 12096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12096
agcacaatat cagaatccca                                                   20


<210> 12097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12097
ttacaacaga aaatttcacc                                                   20


<210> 12098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 12098
gtagtataat gattacagct                                                   20


<210> 12099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12099
caaatctttt cttaatcttt                                                   20


<210> 12100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 12100
tcccccagct gccaaaagtg                                                   20


<210> 12101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12101
tggatgctga aggctcacat                                                   20


<210> 12102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12102
aaagggagag cctgcatcca                                                   20


<210> 12103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 12103
tttgttttgg aactactcca                                                   20


<210> 12104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 12104
cacagcatca gagatgccaa                                                   20


<210> 12105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 12105
taaatctcag atttctctct                                                   20


<210> 12106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 12106
ctaagtcaaa attctttgtt                                                   20


<210> 12107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 12107
tcaaaattct ttgttgtggg                                                   20


<210> 12108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 12108
aagtcctaac cctggcatgt                                                   20


<210> 12109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 12109
aatgaagatg aggtcattgt                                                   20


<210> 12110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 12110
gggtccaaat ccaatataac                                                   20


<210> 12111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 12111
acacacaggg agaaaactac                                                   20


<210> 12112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 12112
gtgagtaccg ggccagagat                                                   20


<210> 12113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 12113
atgatgcagc tgcaagctgc                                                   20


<210> 12114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 12114
aaagttagaa agcagcaagg                                                   20


<210> 12115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12115
ctagcctcca gaactggcaa                                                   20


<210> 12116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 12116
atttctgttg ttgtaagcca                                                   20


<210> 12117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 12117
cgtaagaaac taatacatcc                                                   20


<210> 12118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 12118
taataaatat ttattgacaa                                                   20


<210> 12119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 12119
tgtagtgtgt tgttaatgtt                                                   20


<210> 12120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 12120
gcattcttag aaacagtgaa                                                   20


<210> 12121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 12121
gtgaaaagag tattattctc                                                   20


<210> 12122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 12122
aaaatatttt gatttgattc                                                   20


<210> 12123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 12123
cataaactct gttgagaaac                                                   20


<210> 12124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 12124
ggatgctagg tcataaaaga                                                   20


<210> 12125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 12125
ggtcataaaa gagagggttt                                                   20


<210> 12126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12126
gggaaatata cccatagccc                                                   20


<210> 12127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12127
gaaaataata tctcagaaac                                                   20


<210> 12128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 12128
aacctgaatc caagtaagct                                                   20


<210> 12129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 12129
ataataattg tacatattta                                                   20


<210> 12130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 12130
tacattatat aattatcaaa                                                   20


<210> 12131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 12131
attcatgttg ccacaaataa                                                   20


<210> 12132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12132
gatttcatta tttcttatgg                                                   20


<210> 12133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 12133
cagtgcagca ataaacatat                                                   20


<210> 12134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 12134
acatactgat ttcatttcat                                                   20


<210> 12135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 12135
tttacttagt attgggactg                                                   20


<210> 12136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 12136
cattctcaca atcagtgtgt                                                   20


<210> 12137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 12137
ttgatggtag ccattttaac                                                   20


<210> 12138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 12138
ttcaggtctt ttgtccattt                                                   20


<210> 12139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 12139
atttgttttt tttgtcgttg                                                   20


<210> 12140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 12140
ttttgtcgtt gttgagttgt                                                   20


<210> 12141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 12141
ttacatttaa gtagtctatt                                                   20


<210> 12142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 12142
tccaggttac ttgggctatt                                                   20


<210> 12143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12143
tttttttttt tttttctgta                                                   20


<210> 12144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 12144
aatgtcactg gtattttgat                                                   20


<210> 12145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 12145
cattaaacct gtagattgct                                                   20


<210> 12146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 12146
attattctaa tccatgaaca                                                   20


<210> 12147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 12147
ttttttgtag ctattgtaaa                                                   20


<210> 12148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12148
ttttgtgtcc tccaacatta                                                   20


<210> 12149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 12149
aaatctacta ctttttttca                                                   20


<210> 12150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 12150
tcagatcata taaaaacaaa                                                   20


<210> 12151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 12151
gctagaactt cattactatg                                                   20


<210> 12152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 12152
tggttagtat catgttagct                                                   20


<210> 12153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 12153
ttgataattt ttatcaaata                                                   20


<210> 12154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 12154
tttttatcaa ataaaggata                                                   20


<210> 12155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 12155
acgatttcca gttgagcatg                                                   20


<210> 12156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 12156
ataatctttt tgataggctg                                                   20


<210> 12157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 12157
tttttgatag gctgttggat                                                   20


<210> 12158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 12158
attttgcatc tgtgttcatc                                                   20


<210> 12159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 12159
tccctgtctt gttctggtat                                                   20


<210> 12160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12160
ttggggtaat attggccttg                                                   20


<210> 12161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12161
ggtaatattg gccttgtaga                                                   20


<210> 12162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12162
gccttgtaga atgaatttag                                                   20


<210> 12163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 12163
tcctttcctt ttgatttttt                                                   20


<210> 12164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12164
tttttttgga ataatttaag                                                   20


<210> 12165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12165
gttcttcttt aaatgtttgg                                                   20


<210> 12166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 12166
gttactcatt attggtctgt                                                   20


<210> 12167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 12167
gtcttggcaa gttgtatgtg                                                   20


<210> 12168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 12168
cattaggttt tccaatttgt                                                   20


<210> 12169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 12169
aaatttaggc aaacaattca                                                   20


<210> 12170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 12170
gcatttgtct aattatttat                                                   20


<210> 12171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 12171
atgacataaa tatataaatt                                                   20


<210> 12172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 12172
aaattaggag ttactttcta                                                   20


<210> 12173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 12173
aaaataaaag ttgcaaaaga                                                   20


<210> 12174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 12174
aagtgggaga tgaagattat                                                   20


<210> 12175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 12175
agcaggaaaa gttagcatag                                                   20


<210> 12176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12176
atgtacacta ttttagtgat                                                   20


<210> 12177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 12177
acaaaacaaa acaaaaatga                                                   20


<210> 12178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 12178
atggaaaatt ttttatgaag                                                   20


<210> 12179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 12179
aagtcagtag cactaagaac                                                   20


<210> 12180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 12180
tgcataccat ggaaatgtaa                                                   20


<210> 12181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12181
ccatggaaat gtaatagagt                                                   20


<210> 12182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12182
gaaaaaaatt agtgaaaatc                                                   20


<210> 12183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12183
ttagtgaaaa tcaagaatat                                                   20


<210> 12184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 12184
tacgctttcg gaagggctca                                                   20


<210> 12185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 12185
agggctcatg gaataagtga                                                   20


<210> 12186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12186
ataagtgaca gagtaatttt                                                   20


<210> 12187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 12187
gacaaattat taagtccaat                                                   20


<210> 12188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 12188
ataactctag ctttataact                                                   20


<210> 12189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 12189
aataaaatca cttcctttta                                                   20


<210> 12190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12190
atgttgcaac tcaacatact                                                   20


<210> 12191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12191
caactcaaca tactaagaat                                                   20


<210> 12192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12192
tcctgaagtg ctttaacacc                                                   20


<210> 12193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 12193
gcaactgtct gccaggcaat                                                   20


<210> 12194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 12194
ataattttaa tcttctttaa                                                   20


<210> 12195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 12195
aatcttcttt aaatgggtga                                                   20


<210> 12196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 12196
agttagaaaa aaataggtga                                                   20


<210> 12197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 12197
tgctccttaa aaggcatacg                                                   20


<210> 12198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 12198
gaacacggtt ttaaaatttt                                                   20


<210> 12199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 12199
acagctggcc ttctgtatcc                                                   20


<210> 12200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 12200
atccctgggt cccacatctg                                                   20


<210> 12201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 12201
aatttaaagt gtacatatga                                                   20


<210> 12202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 12202
cattgtgcca ttttatataa                                                   20


<210> 12203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 12203
ctactcgccc atagatatcg                                                   20


<210> 12204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 12204
tgtattgatt ttttttgaga                                                   20


<210> 12205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 12205
tctcactctg tagtccaagc                                                   20


<210> 12206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 12206
aagtccacta taaattcatg                                                   20


<210> 12207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 12207
cactataaat tcatggaggg                                                   20


<210> 12208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 12208
ctcactagaa atatgcaggt                                                   20


<210> 12209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 12209
gggcacaaaa aaaggtttta                                                   20


<210> 12210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12210
ttaaagagtt cctgttctca                                                   20


<210> 12211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12211
aaaattaaaa tttaagatta                                                   20


<210> 12212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 12212
ccatttgggg agaaattagg                                                   20


<210> 12213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 12213
taaataacat tttgagaaca                                                   20


<210> 12214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 12214
atttaataga tgataaatac                                                   20


<210> 12215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 12215
aatacaaggg tgatgccttg                                                   20


<210> 12216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 12216
gaaatcccaa gcaaagtgtg                                                   20


<210> 12217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 12217
tttggtacag gtaaaaatct                                                   20


<210> 12218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGAT

<400> 12218
agtacataat tcgagacttt                                                   20


<210> 12219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12219
gcaactgggg aaaaagtttg                                                   20


<210> 12220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 12220
gaaaaagttt gaagaattgc                                                   20


<210> 12221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 12221
aactttttta aaaaaattag                                                   20


<210> 12222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 12222
aattagctgg gtgttgtggc                                                   20


<210> 12223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 12223
aactcaggag gtggaggcag                                                   20


<210> 12224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 12224
caggaggatc acttgagccc                                                   20


<210> 12225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 12225
ctgtactcca gactgggcaa                                                   20


<210> 12226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GCGGAT

<400> 12226
gagagagaga gcgatacttt                                                   20


<210> 12227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 12227
agagcgatac tttgcggatc                                                   20


<210> 12228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 12228
gcggatcatg gatacatcat                                                   20


<210> 12229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12229
tgagagtgaa atgattagga                                                   20


<210> 12230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 12230
aaataatcaa ataagtaaac                                                   20


<210> 12231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 12231
aatggtttag gcaaaaagta                                                   20


<210> 12232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 12232
aaaggtgatg aaaaggagag                                                   20


<210> 12233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 12233
ttttcaactg acaggaaaca                                                   20


<210> 12234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12234
tagtaagaaa actttaccag                                                   20


<210> 12235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CCGAAT

<400> 12235
cactttgctg tattcactat                                                   20


<210> 12236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TCGGAT

<400> 12236
cagcattcat attttccaaa                                                   20


<210> 12237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 12237
tggcactgtc actgtgaggc                                                   20


<210> 12238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 12238
gtcactgtga ggctgggatt                                                   20


<210> 12239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12239
ggctttttgg aaaatgcttt                                                   20


<210> 12240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 12240
aatctggagg ttgtttgcat                                                   20


<210> 12241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 12241
aataggttta ggacctatat                                                   20


<210> 12242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGGT

<400> 12242
cctatatcag ggtggggaga                                                   20


<210> 12243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CCGAAT

<400> 12243
aataaaataa gtacactttt                                                   20


<210> 12244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ACGGAT

<400> 12244
atttctgcac cttttcacac                                                   20


<210> 12245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 12245
cacatgagag agacagaggc                                                   20


<210> 12246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 12246
cccctgcaga ctcagcagca                                                   20


<210> 12247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12247
gagggtcagc catacccagg                                                   20


<210> 12248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 12248
gaattaccat ggggagcaga                                                   20


<210> 12249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12249
attctgtcca agaagcgtgc                                                   20


<210> 12250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 12250
cttgaagcaa agttttattt                                                   20


<210> 12251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 12251
ccaggaaaca aaaaaggaaa                                                   20


<210> 12252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 12252
attctggagg tcggaggtct                                                   20


<210> 12253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 12253
ttgtgtatat ttgttttaat                                                   20


<210> 12254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 12254
aggaatattg gtgaagatct                                                   20


<210> 12255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 12255
caagcgttaa accattttaa                                                   20


<210> 12256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 12256
tctaatattt ctataaccta                                                   20


<210> 12257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12257
actggcaata aaatgatcaa                                                   20


<210> 12258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 12258
ctaatgtgga aggctatatc                                                   20


<210> 12259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 12259
tggtagttcc tccattagtc                                                   20


<210> 12260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12260
aagagttggt tatcaacttt                                                   20


<210> 12261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12261
ttctgtatac tttctttgcc                                                   20


<210> 12262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12262
ttgccaagaa ttaataatta                                                   20


<210> 12263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 12263
aataattaaa gaataataat                                                   20


<210> 12264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ACGAAT

<400> 12264
ttagttaaca ctaattctac                                                   20


<210> 12265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 12265
ctaataagca tcttaaaaac                                                   20


<210> 12266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 12266
ttaaaaacaa ggattagacc                                                   20


<210> 12267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 12267
agagaagata ctaaaaaata                                                   20


<210> 12268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 12268
gaaaatgtgg tgagagccaa                                                   20


<210> 12269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 12269
ccaagggaat gcctttccct                                                   20


<210> 12270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12270
gcctttccct ttgaatttgc                                                   20


<210> 12271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 12271
actttgggag gcgacggagg                                                   20


<210> 12272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 12272
aggctggatc acctgaggtc                                                   20


<210> 12273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12273
tactcaggag gctgaggcag                                                   20


<210> 12274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 12274
tgaacctggg aggtggaggt                                                   20


<210> 12275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 12275
aacagagaag aagaaacaaa                                                   20


<210> 12276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 12276
gcatttcatt ccatattgga                                                   20


<210> 12277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 12277
cttatttatt actacaactt                                                   20


<210> 12278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12278
ttgagggtga tcaacaatta                                                   20


<210> 12279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 12279
acaattatag aatggtaatc                                                   20


<210> 12280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12280
ttttttgtgc agtaaaaatc                                                   20


<210> 12281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 12281
cagtatcatt tagtgtgtga                                                   20


<210> 12282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12282
atcatttagt gtgtgactgg                                                   20


<210> 12283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12283
gtaagtttct gtcctgactt                                                   20


<210> 12284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 12284
ctgttaccat atcccacctt                                                   20


<210> 12285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 12285
caagtcaacg tggcagattt                                                   20


<210> 12286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 12286
tggcagattt gagaattgag                                                   20


<210> 12287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12287
cagtcataga agatacgtaa                                                   20


<210> 12288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 12288
atgaattgac attcctatgt                                                   20


<210> 12289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12289
atagaaacct ttgccttaaa                                                   20


<210> 12290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 12290
tgattttgaa aaatataaat                                                   20


<210> 12291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 12291
cacgcggaac acaatcagga                                                   20


<210> 12292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 12292
gaggttacct agagccccta                                                   20


<210> 12293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 12293
tcagcatgtt caatgttggc                                                   20


<210> 12294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 12294
ccaatcttga tttttgttca                                                   20


<210> 12295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 12295
gaaactatgt acttttagtt                                                   20


<210> 12296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12296
aatttgtgat atttttcttt                                                   20


<210> 12297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 12297
gataaaatct agcatattag                                                   20


<210> 12298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGAT

<400> 12298
atcagacaac aattgttttg                                                   20


<210> 12299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12299
tattagcgtg tacttcaaat                                                   20


<210> 12300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12300
ttctttaagt gcatttgtca                                                   20


<210> 12301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 12301
ttaagtgcat ttgtcaatga                                                   20


<210> 12302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12302
aaagaaatac ccctttatta                                                   20


<210> 12303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12303
cttagtttat gtttaccagt                                                   20


<210> 12304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 12304
gcctacttgg aaatactcat                                                   20


<210> 12305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 12305
gtttgctaaa tactttataa                                                   20


<210> 12306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12306
atcattttta gacagcattt                                                   20


<210> 12307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 12307
atagcatatt aaaatttcag                                                   20


<210> 12308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12308
tgacacagtc actattttca                                                   20


<210> 12309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 12309
actattttca aagaatttat                                                   20


<210> 12310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 12310
ttttctgatc tgactactgt                                                   20


<210> 12311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12311
cttaaaaagg caacaccgaa                                                   20


<210> 12312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 12312
gcaacaccga aatgaatcct                                                   20


<210> 12313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 12313
tttgggtaca ctttgactca                                                   20


<210> 12314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 12314
atgtttaggt ctataactgc                                                   20


<210> 12315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 12315
gagtcaattt tcaaataatg                                                   20


<210> 12316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 12316
tgtgaccagg taaatccttt                                                   20


<210> 12317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 12317
taaatccttt ctgagttcac                                                   20


<210> 12318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CCGGAT

<400> 12318
aaggtactta tttgcaagat                                                   20


<210> 12319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12319
aaagataaat agaagggaag                                                   20


<210> 12320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 12320
agcacatggg gaaaaacatt                                                   20


<210> 12321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 12321
aaagttattc atggtttatg                                                   20


<210> 12322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 12322
aaactggcat tttgtttacc                                                   20


<210> 12323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 12323
tctggcatca attttactaa                                                   20


<210> 12324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 12324
gatcaccttc ttgcctatcc                                                   20


<210> 12325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12325
agaaagcatt taatcctccc                                                   20


<210> 12326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 12326
aatgataaaa ttaaatacta                                                   20


<210> 12327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 12327
ggcatatcac tcatataatg                                                   20


<210> 12328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 12328
atccattcat atggaaagtt                                                   20


<210> 12329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 12329
gacaactaaa aagagaaact                                                   20


<210> 12330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 12330
ttcctatagc aagtacattt                                                   20


<210> 12331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 12331
atttttgaat tcctcagtca                                                   20


<210> 12332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 12332
ggtaattgca agatctacaa                                                   20


<210> 12333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 12333
caataaaata gatacacttt                                                   20


<210> 12334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12334
atggagagca attccagatc                                                   20


<210> 12335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 12335
ggagaaaaaa gcagagaaca                                                   20


<210> 12336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 12336
tgcctagatg aagcataaga                                                   20


<210> 12337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 12337
tctcaccatt tatttaggag                                                   20


<210> 12338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 12338
agacactttg cccccacaat                                                   20


<210> 12339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGGT

<400> 12339
gcccccacaa tgggaatgtg                                                   20


<210> 12340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 12340
tggggcatat tgtcagggga                                                   20


<210> 12341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GCGAAT

<400> 12341
ttagaagaga caatttttga                                                   20


<210> 12342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 12342
tttgtaagat tatatagtga                                                   20


<210> 12343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 12343
agtgacagaa tcacgtagct                                                   20


<210> 12344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 12344
atcacccaac atctgtcttt                                                   20


<210> 12345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12345
ttaaaaccat tttatggtct                                                   20


<210> 12346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12346
atggtctctg aattcttcct                                                   20


<210> 12347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12347
gatttatgtt aattttattt                                                   20


<210> 12348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 12348
cattgctctc tgtctgaggt                                                   20


<210> 12349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 12349
atcaattaat gtcttaagaa                                                   20


<210> 12350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 12350
atcttgctta tatagctgta                                                   20


<210> 12351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 12351
taaaagtaga gcctagattg                                                   20


<210> 12352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGAT

<400> 12352
cagttttata ttggtaaaat                                                   20


<210> 12353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 12353
tgcttgcttc atattcttgt                                                   20


<210> 12354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 12354
catattcttg tgaggattaa                                                   20


<210> 12355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 12355
atcatcacct ctctgccttt                                                   20


<210> 12356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGGT

<400> 12356
ctgtagtgct gtgtatctaa                                                   20


<210> 12357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12357
gtgctgtgta tctaaagggg                                                   20


<210> 12358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 12358
agtattctct gataaatttc                                                   20


<210> 12359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 12359
aaggaacaat tagtgaaatg                                                   20


<210> 12360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 12360
atacaggcat agatatgtgc                                                   20


<210> 12361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12361
tgtgctatag tctgtcaaac                                                   20


<210> 12362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 12362
tagttttgta gttttcactt                                                   20


<210> 12363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 12363
attgaaatat atgtgtggcc                                                   20


<210> 12364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 12364
tagcatatgt ttgaagctta                                                   20


<210> 12365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 12365
tggtaatgca gcatagcata                                                   20


<210> 12366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 12366
agagatatcc tggaaactcc                                                   20


<210> 12367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 12367
actgcacatt ggagagatag                                                   20


<210> 12368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 12368
cacattggag agatagcaga                                                   20


<210> 12369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 12369
taggagctac catttattag                                                   20


<210> 12370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 12370
gataataatg tatcatctca                                                   20


<210> 12371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 12371
acaactcaaa taagattcct                                                   20


<210> 12372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 12372
tccaaatttc ttcatagaaa                                                   20


<210> 12373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 12373
caagtacctt tttacaaaaa                                                   20


<210> 12374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 12374
acaaaaatgg gattttatct                                                   20


<210> 12375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12375
agttagatgc ctacaacaca                                                   20


<210> 12376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 12376
atgcctacaa cacatagaat                                                   20


<210> 12377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12377
atagaatgag gattaggcta                                                   20


<210> 12378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 12378
tgttactgct gcgtcgctcc                                                   20


<210> 12379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ACGAAT

<400> 12379
cttgcagaaa acaaggagcc                                                   20


<210> 12380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 12380
aaaacaagga gccacgaatg                                                   20


<210> 12381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 12381
aagaaaactt cttccactta                                                   20


<210> 12382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12382
ttaagggatg aaacaatttg                                                   20


<210> 12383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 12383
agctctctaa tattctggcc                                                   20


<210> 12384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 12384
atgcttatat gactcatgtc                                                   20


<210> 12385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 12385
ccagggtgta aatcctttgg                                                   20


<210> 12386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 12386
ttttttactg tgtatatcag                                                   20


<210> 12387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 12387
tagtttagaa aagtgatttg                                                   20


<210> 12388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGAT

<400> 12388
cagaagcaat ggttcatctt                                                   20


<210> 12389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 12389
gttcatcttg gggatttgtg                                                   20


<210> 12390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 12390
aaagagaact tccacataaa                                                   20


<210> 12391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGGT

<400> 12391
tattagtagt tgatgtggtt                                                   20


<210> 12392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 12392
agttgatgtg gttgggggtg                                                   20


<210> 12393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 12393
aggcttctcc aaagttccaa                                                   20


<210> 12394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 12394
ttctccaaag ttccaaatgg                                                   20


<210> 12395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 12395
tataaaagtt attctatagt                                                   20


<210> 12396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 12396
ttctgaaaat tagtttatta                                                   20


<210> 12397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CCGAGT

<400> 12397
aaatcactca ctatcctctc                                                   20


<210> 12398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TCGGGT

<400> 12398
tttttctcta gcattctgcc                                                   20


<210> 12399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 12399
ggtgatacac atttagcaat                                                   20


<210> 12400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGGT

<400> 12400
aatttgggtg gtacctgatt                                                   20


<210> 12401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 12401
tagcactttt agagctcagt                                                   20


<210> 12402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 12402
gccaagacgt taacacttaa                                                   20


<210> 12403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 12403
cgttttcttt acacaatgat                                                   20


<210> 12404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12404
aataaagctc tattgtattt                                                   20


<210> 12405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 12405
aaagttttac aaggtaattt                                                   20


<210> 12406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12406
aattaactcc atatcatcaa                                                   20


<210> 12407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 12407
actctatggt ttaataaaga                                                   20


<210> 12408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12408
ttgagttatt tgaaaaataa                                                   20


<210> 12409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 12409
ttggcctaaa tgaaacttct                                                   20


<210> 12410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 12410
ggaattccct aggtagtacc                                                   20


<210> 12411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12411
accattatta aaatgctgca                                                   20


<210> 12412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 12412
tgcactgaat atttgtgcat                                                   20


<210> 12413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12413
cttctcaaac atttacactg                                                   20


<210> 12414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 12414
ctgaagaatc tctctggaaa                                                   20


<210> 12415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 12415
ggattaagga ggaaactttc                                                   20


<210> 12416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 12416
gttttagtca taccccatag                                                   20


<210> 12417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 12417
gtatcaattc tagctcagcc                                                   20


<210> 12418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 12418
cctttttcca caccagaaat                                                   20


<210> 12419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12419
tttgcatttc tacctctagg                                                   20


<210> 12420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 12420
tatgccatgg caaccacagc                                                   20


<210> 12421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12421
ttaaacacat tttcagtacg                                                   20


<210> 12422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 12422
atcaaatatt aataatatca                                                   20


<210> 12423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12423
gctttctttg ctttttaaaa                                                   20


<210> 12424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 12424
attttttttc aaaatagttt                                                   20


<210> 12425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 12425
ataacgtgca ggtttgttac                                                   20


<210> 12426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 12426
tcattgccca cctctcactc                                                   20


<210> 12427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 12427
tgttcctgtt ttagtttgct                                                   20


<210> 12428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 12428
agtctatcat tgatgggcat                                                   20


<210> 12429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 12429
ggttcccagt ctttgctatt                                                   20


<210> 12430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12430
gtgtgcatgt gtctttacca                                                   20


<210> 12431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 12431
atagaatgat atgtaatctt                                                   20


<210> 12432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 12432
tttgggtata tacccagtaa                                                   20


<210> 12433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 12433
tatacccagt aatgggattg                                                   20


<210> 12434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 12434
gatggtatct cattgtggtt                                                   20


<210> 12435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 12435
tttttcatat gtttaagtta                                                   20


<210> 12436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 12436
aaattgttca actcccactt                                                   20


<210> 12437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 12437
tcttcctgta ttagtttgct                                                   20


<210> 12438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 12438
aatttaacat tgatgggcat                                                   20


<210> 12439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12439
gtgtgcatgt gtctttgtag                                                   20


<210> 12440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 12440
tttcggtata tacccagtaa                                                   20


<210> 12441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 12441
tttctggttc taggtcctta                                                   20


<210> 12442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 12442
ctatttcttc atagcctcac                                                   20


<210> 12443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 12443
atcctttgcc cactttttga                                                   20


<210> 12444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12444
actccatagc caatatcata                                                   20


<210> 12445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 12445
tttaaaaact ggcacaagac                                                   20


<210> 12446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 12446
actgctattc aatatagtgt                                                   20


<210> 12447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 12447
tcagacaaga gaaagaaata                                                   20


<210> 12448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 12448
aagcaacttc agcaaggtat                                                   20


<210> 12449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12449
gacaagcaga gagccaaatc                                                   20


<210> 12450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 12450
ccatttgcaa ttgctataaa                                                   20


<210> 12451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 12451
ataaagagaa taaaatacct                                                   20


<210> 12452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 12452
acctaggaat acagcttaca                                                   20


<210> 12453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 12453
tggaaaaaca ttccatactc                                                   20


<210> 12454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12454
attccatact catggatagg                                                   20


<210> 12455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 12455
aattaccatt gacatcttca                                                   20


<210> 12456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 12456
caaacagaca tataggccaa                                                   20


<210> 12457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12457
agacatatag gccaatggaa                                                   20


<210> 12458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 12458
acaaaaacaa gcaatgtgga                                                   20


<210> 12459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 12459
tatacaaaaa ttaactcaag                                                   20


<210> 12460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 12460
ccaaagccaa aattgacaaa                                                   20


<210> 12461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 12461
acagcaaaag aaactaacat                                                   20


<210> 12462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12462
cagagtgaac aggcaaacta                                                   20


<210> 12463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12463
tctgacaaag gtctaatatt                                                   20


<210> 12464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 12464
atcatacaaa gcattttaaa                                                   20


<210> 12465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 12465
aaagcatttt aaagtgaatt                                                   20


<210> 12466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 12466
ttatttgtgt ttctttaatt                                                   20


<210> 12467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CCGAAT

<400> 12467
aagtgcatct tacataattt                                                   20


<210> 12468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 12468
ctgcagctat tctgagaaaa                                                   20


<210> 12469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12469
aatcattgtt atgtgtacta                                                   20


<210> 12470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12470
aagttagagg aaatagccac                                                   20


<210> 12471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12471
ggagagaaaa acttagagaa                                                   20


<210> 12472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 12472
ttgcatcttt aactttaaat                                                   20


<210> 12473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 12473
ggtacttaac taggacccca                                                   20


<210> 12474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 12474
ctacccatat tattagtgat                                                   20


<210> 12475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 12475
taattttggt aataagataa                                                   20


<210> 12476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 12476
taaaggtttt cccagtaatc                                                   20


<210> 12477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 12477
aaagctcgtg tagccataat                                                   20


<210> 12478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 12478
cgagaaagaa cattataggt                                                   20


<210> 12479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 12479
tcttctatag ggggacaata                                                   20


<210> 12480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 12480
atagggggac aatattgaat                                                   20


<210> 12481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12481
gacaatattg aataaggatt                                                   20


<210> 12482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 12482
cataagtctg tctgtgaaaa                                                   20


<210> 12483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 12483
ctttctgtct gtataattct                                                   20


<210> 12484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 12484
gtataattct tggaatagat                                                   20


<210> 12485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12485
gccagtgtac acagagcctg                                                   20


<210> 12486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 12486
agaagcagca agatggacag                                                   20


<210> 12487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 12487
aatatgtgta cccaagtcca                                                   20


<210> 12488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 12488
gtccaaggaa tccctttgct                                                   20


<210> 12489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 12489
aacatgacat tcagtcacct                                                   20


<210> 12490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 12490
ctatgagtca catttaattg                                                   20


<210> 12491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 12491
gagtcacatt taattggaga                                                   20


<210> 12492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 12492
ttggagaatg agtggaactt                                                   20


<210> 12493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 12493
attatccaac caacttttgg                                                   20


<210> 12494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 12494
tgtctcaaag tcttgctttc                                                   20


<210> 12495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 12495
aactgtgaac attttaaaga                                                   20


<210> 12496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 12496
agactggatt tgctgtggga                                                   20


<210> 12497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 12497
tggatttgct gtgggacaga                                                   20


<210> 12498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12498
gaaatatata aaaagcaata                                                   20


<210> 12499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12499
gaaaacaaat attacatacc                                                   20


<210> 12500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 12500
aaccacaaag gagagcatct                                                   20


<210> 12501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12501
ataaaaatat tctgttgaag                                                   20


<210> 12502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 12502
gacctccttt atgtttaggt                                                   20


<210> 12503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 12503
ggtgagggtg gaggttgtgg                                                   20


<210> 12504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 12504
ggctacagtg tggtgagagg                                                   20


<210> 12505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CCGGAT

<400> 12505
atggcagagg taggcagggg                                                   20


<210> 12506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CGGAAT

<400> 12506
aggcaggggc cggatcatgt                                                   20


<210> 12507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 12507
ggaatttgca tatcatagaa                                                   20


<210> 12508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 12508
tgcatatcat agaaatgagt                                                   20


<210> 12509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 12509
tcgtccttgt gcaaacatcc                                                   20


<210> 12510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 12510
gctcctgggc tgcaaacctg                                                   20


<210> 12511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 12511
tcagtaaggc agtaacataa                                                   20


<210> 12512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 12512
tctgattatt gggagacttt                                                   20


<210> 12513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 12513
gactatgaaa tcagatattc                                                   20


<210> 12514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 12514
gaaatcagat attcttggat                                                   20


<210> 12515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 12515
ttctatccct tcttaagtaa                                                   20


<210> 12516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12516
tgcatctgta aaatacgtat                                                   20


<210> 12517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 12517
aagttgttaa atagtataaa                                                   20


<210> 12518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 12518
tgtactagct gctcaaaaac                                                   20


<210> 12519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 12519
atttgagata aaactattga                                                   20


<210> 12520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 12520
aaacactcct gaacctcggg                                                   20


<210> 12521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 12521
ctcgggaagg atgggcctgg                                                   20


<210> 12522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 12522
ggaaggatgg gcctggtaga                                                   20


<210> 12523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 12523
ctggtagagt gagtatggga                                                   20


<210> 12524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 12524
aacatccaaa atattttaat                                                   20


<210> 12525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 12525
tccaaaatat tttaataagg                                                   20


<210> 12526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12526
ttaataagga tggattactt                                                   20


<210> 12527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12527
atttatcaac cactgaggag                                                   20


<210> 12528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12528
ccactgagga gctgaattat                                                   20


<210> 12529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12529
tactgtattt aacacagtat                                                   20


<210> 12530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 12530
tctttaaaaa tgggaaaaaa                                                   20


<210> 12531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 12531
tgcttgtgca tattcaaaag                                                   20


<210> 12532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12532
tgggatgatt ctgaaagata                                                   20


<210> 12533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12533
atgattctga aagataaaga                                                   20


<210> 12534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 12534
tacttggcag gctgaggcag                                                   20


<210> 12535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 12535
ctgcattcca gcctaggcga                                                   20


<210> 12536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12536
atttccacaa aaacttgtac                                                   20


<210> 12537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12537
acccaaatgt ccatcaactg                                                   20


<210> 12538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 12538
gcatagatac atactatacc                                                   20


<210> 12539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 12539
ttccatgtat attaaatcta                                                   20


<210> 12540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 12540
atgtatatta aatctacaga                                                   20


<210> 12541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 12541
gctgggagaa aagggaaatg                                                   20


<210> 12542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 12542
ggaatgacta ctaacgggcc                                                   20


<210> 12543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 12543
gtggcgatcg ttgcacaact                                                   20


<210> 12544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 12544
ctctgagtat agtttaaaaa                                                   20


<210> 12545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 12545
gagttataca gtttaaaaaa                                                   20


<210> 12546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 12546
caataaacct atttttaaaa                                                   20


<210> 12547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 12547
gcagcataac ggcaaaggtt                                                   20


<210> 12548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGGT

<400> 12548
taacggcaaa ggttgtgggt                                                   20


<210> 12549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 12549
aaattgatat aacaaaaata                                                   20


<210> 12550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 12550
tattaaatct aatgaagatt                                                   20


<210> 12551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 12551
ggcttgggcc tatggaagtg                                                   20


<210> 12552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGAT

<400> 12552
actctgagaa aactagtgca                                                   20


<210> 12553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 12553
tattagaaaa acaggaggaa                                                   20


<210> 12554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 12554
tttcagcagg aggtgagaca                                                   20


<210> 12555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 12555
gtgggttaat ttatttgatt                                                   20


<210> 12556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12556
ccatgctggc taccaaatgg                                                   20


<210> 12557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 12557
ggagaaactc tcacaaccaa                                                   20


<210> 12558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12558
cattctcatc aaatcatctg                                                   20


<210> 12559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 12559
ctttgaggaa ataaaaacca                                                   20


<210> 12560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12560
ttgacttctc cctctctctc                                                   20


<210> 12561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 12561
tttatagcca aatttcttgg                                                   20


<210> 12562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 12562
ctctttctct gtgttctttt                                                   20


<210> 12563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12563
ttctgggtcc tcttttctac                                                   20


<210> 12564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 12564
tctacctgaa ttctaaatgt                                                   20


<210> 12565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 12565
tctatctact taaaaatatc                                                   20


<210> 12566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 12566
tttctttttg ctgattgctc                                                   20


<210> 12567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 12567
acgcaccaat aaatgaaagt                                                   20


<210> 12568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12568
ctacatttca gaagaaaata                                                   20


<210> 12569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 12569
taatgtacag atttggaaga                                                   20


<210> 12570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 12570
ttcgctcttg ttgcccaggc                                                   20


<210> 12571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CCGAGT

<400> 12571
ctcaccgcaa cctctgcctc                                                   20


<210> 12572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 12572
gattctcctg cctcagcctc                                                   20


<210> 12573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 12573
gcctcagcct cctgagtagc                                                   20


<210> 12574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CGGGGT

<400> 12574
ttttgtattt ttagtagaga                                                   20


<210> 12575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12575
tgaagcaatt ccagaaagcg                                                   20


<210> 12576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 12576
aaaggctgtc tgtgtacata                                                   20


<210> 12577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 12577
aaatactcct gctcatgttg                                                   20


<210> 12578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 12578
tctccgaact tctcttggtt                                                   20


<210> 12579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 12579
tcagaaatag gagcaagact                                                   20


<210> 12580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 12580
aacaatcaga aactggaaaa                                                   20


<210> 12581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 12581
atttgatttt atttatcaca                                                   20


<210> 12582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 12582
attacttttt attatctaag                                                   20


<210> 12583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 12583
tcgtgacttc cataccacac                                                   20


<210> 12584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGAT

<400> 12584
cagtgagaga caccatgcta                                                   20


<210> 12585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12585
agaaactcta attgatactt                                                   20


<210> 12586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 12586
tctgaattaa gcagacttct                                                   20


<210> 12587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 12587
aactcgtcat tggttacaaa                                                   20


<210> 12588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 12588
tttgctttgt acaaatcttt                                                   20


<210> 12589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 12589
aactttaaga tgttatagtt                                                   20


<210> 12590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 12590
ttttttatga tatagaaatt                                                   20


<210> 12591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 12591
actgctagat agcttagaac                                                   20


<210> 12592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 12592
tgtagcagct ttctatatat                                                   20


<210> 12593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 12593
ctaaagtctt cttcactctc                                                   20


<210> 12594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 12594
taatgtttca ttattttcaa                                                   20


<210> 12595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 12595
acactcagac agaacacagt                                                   20


<210> 12596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 12596
tcagaaagct tcttcactga                                                   20


<210> 12597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12597
tttgtaatga cataaagcct                                                   20


<210> 12598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 12598
cctaattcaa aaaaagcctt                                                   20


<210> 12599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12599
aaaataggaa catattctca                                                   20


<210> 12600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 12600
gtattttaaa atcaattaaa                                                   20


<210> 12601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 12601
tgtttaaccc cactctcacc                                                   20


<210> 12602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12602
ttttcaatgc tcggagaact                                                   20


<210> 12603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 12603
ctgtcacata tctgtaatag                                                   20


<210> 12604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 12604
aagaacaact cccaaatagt                                                   20


<210> 12605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 12605
actcccaaat agttggagtt                                                   20


<210> 12606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 12606
cacaccaatt acttcttacc                                                   20


<210> 12607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12607
caaattctgt taaatacctg                                                   20


<210> 12608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 12608
aaatacctgt agaattaaat                                                   20


<210> 12609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 12609
agaattaaat cagaattatt                                                   20


<210> 12610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 12610
agaattattc agaatttaga                                                   20


<210> 12611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 12611
agatattata tattattaaa                                                   20


<210> 12612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 12612
tccatagaga taaaacatag                                                   20


<210> 12613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 12613
ggaaattgaa gtgactgcta                                                   20


<210> 12614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 12614
gaagtgactg ctaatgagta                                                   20


<210> 12615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 12615
atgagtacag agtttctatt                                                   20


<210> 12616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12616
tgtcaatata ctgaaaaaca                                                   20


<210> 12617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 12617
gaattgtata ctttaaaatt                                                   20


<210> 12618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 12618
aattgtgaat tttgtagtat                                                   20


<210> 12619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 12619
tgatggaaaa gaggttaggc                                                   20


<210> 12620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 12620
aagaggttag gcagggatga                                                   20


<210> 12621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TCGGAT

<400> 12621
gttaggcagg gatgaaggaa                                                   20


<210> 12622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 12622
ggatgaagga atcggatatt                                                   20


<210> 12623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 12623
tctaggtggc tccagtgaac                                                   20


<210> 12624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12624
tcaaagtcat taacggaaaa                                                   20


<210> 12625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 12625
ctgataaata catttgggaa                                                   20


<210> 12626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12626
ttgggaaaag agtaacaatt                                                   20


<210> 12627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 12627
atattttcct tgaaaataaa                                                   20


<210> 12628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 12628
aatacaaaaa tataaaataa                                                   20


<210> 12629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 12629
tataaaataa ttgaataata                                                   20


<210> 12630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 12630
ctgtacttgt atttaaaggc                                                   20


<210> 12631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 12631
ctcaatgatg tcacatacct                                                   20


<210> 12632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ACGGGT

<400> 12632
gacaaaatcc agccagttcc                                                   20


<210> 12633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 12633
tccacgggtc acgaagaaaa                                                   20


<210> 12634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 12634
cctacacaga agcctcttgc                                                   20


<210> 12635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 12635
acctaaacac aagattccat                                                   20


<210> 12636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12636
attgggatac tagatgtgaa                                                   20


<210> 12637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 12637
ccactggaag acatatattg                                                   20


<210> 12638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 12638
catatattgg aggatggctg                                                   20


<210> 12639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12639
cagaggtact tgaaataact                                                   20


<210> 12640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12640
taattataaa acatacaccc                                                   20


<210> 12641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 12641
atgtgtaaca tgtctaagaa                                                   20


<210> 12642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 12642
acttcctggc aggaaaagga                                                   20


<210> 12643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 12643
gacatttttg gtccagtccg                                                   20


<210> 12644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 12644
gtcataaata tgcagtttgt                                                   20


<210> 12645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12645
tagtgcacat gatgagcatg                                                   20


<210> 12646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12646
gcatgctgaa taaggtagct                                                   20


<210> 12647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 12647
ggaacaaaag agacgacagt                                                   20


<210> 12648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 12648
agtgggaatt tgaaatattt                                                   20


<210> 12649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 12649
tattttgtct ctttgaacaa                                                   20


<210> 12650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 12650
tgaaattaat aaactaaaac                                                   20


<210> 12651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 12651
aaaaggtata acatctatat                                                   20


<210> 12652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 12652
aattacacca taaagtgcca                                                   20


<210> 12653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 12653
ctggatgtaa tcatttttaa                                                   20


<210> 12654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 12654
gtaatcattt ttaaaaggat                                                   20


<210> 12655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 12655
agtctgcagg aggaaaaaga                                                   20


<210> 12656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 12656
gaaaaagaaa ggatgaaatt                                                   20


<210> 12657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 12657
tatttttatc ataaaacctt                                                   20


<210> 12658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 12658
agcagcacat gttccaaaat                                                   20


<210> 12659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 12659
ttcctaagtt gaaggaacgt                                                   20


<210> 12660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12660
tgaaggaacg tcagagttgg                                                   20


<210> 12661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 12661
tggaagaatc cttccaatca                                                   20


<210> 12662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 12662
ttaaaaggga cttaaattaa                                                   20


<210> 12663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12663
acggtaattt aaaaaacgat                                                   20


<210> 12664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 12664
ctgactttct aaattttata                                                   20


<210> 12665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 12665
aattttatat agggttatca                                                   20


<210> 12666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 12666
cgtattcagg aggtaagtct                                                   20


<210> 12667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 12667
gttccctcaa gaaaacaaat                                                   20


<210> 12668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 12668
gtccccgccc aaatctcatt                                                   20


<210> 12669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 12669
agggacctgg tggtaagtga                                                   20


<210> 12670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 12670
ccagtgctgt tctcatgata                                                   20


<210> 12671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 12671
tgctgttctc atgatagtga                                                   20


<210> 12672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 12672
gttctcatga tagtgagtga                                                   20


<210> 12673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 12673
gtgagttctc atgagatctg                                                   20


<210> 12674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 12674
ctcccctgcc attcagaaca                                                   20


<210> 12675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 12675
agaccatcct ggctaacacg                                                   20


<210> 12676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GCGGGT

<400> 12676
aaaattagcc aggtgtggtg                                                   20


<210> 12677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 12677
taccctggag gctgaggtgg                                                   20


<210> 12678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 12678
tatcataaca ggtaatgaaa                                                   20


<210> 12679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 12679
agtttgaaca aaaataaggc                                                   20


<210> 12680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12680
acagaaaaat ataaaggggg                                                   20


<210> 12681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 12681
aaatataaag ggggaagaat                                                   20


<210> 12682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 12682
gaatgagagt gaagagggaa                                                   20


<210> 12683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12683
atacttgaaa ttttaataaa                                                   20


<210> 12684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 12684
taaaaacttt taagtgattt                                                   20


<210> 12685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 12685
ttttgggtct gcatacacat                                                   20


<210> 12686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 12686
aatttcacaa ttgcttcaaa                                                   20


<210> 12687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 12687
tcaaagagaa taaaatacct                                                   20


<210> 12688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 12688
acctaggaat ccaacttaca                                                   20


<210> 12689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 12689
cactgctcaa ggaaataaaa                                                   20


<210> 12690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12690
attccatgct catgtgtagg                                                   20


<210> 12691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 12691
agaaaaacaa gcaatgggga                                                   20


<210> 12692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 12692
ccatatgtag aaagctgaaa                                                   20


<210> 12693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 12693
tatacaaaaa tcaattcaag                                                   20


<210> 12694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 12694
caaaagacaa aattgacaaa                                                   20


<210> 12695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 12695
acagcaaaat aaactaccat                                                   20


<210> 12696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 12696
tctgacaaaa ggctaatatc                                                   20


<210> 12697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12697
agataccatc tcacaccagt                                                   20


<210> 12698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 12698
aggaaacaac aggtgctgga                                                   20


<210> 12699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 12699
agtcagtgtg gcgattcctc                                                   20


<210> 12700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 12700
ttgacccagc catcccatta                                                   20


<210> 12701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 12701
aaatgtccaa caatgataga                                                   20


<210> 12702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 12702
aatgtggctc atatacacca                                                   20


<210> 12703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 12703
ctatgcagcc ataaaaaatg                                                   20


<210> 12704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 12704
ttcacgtcct ttgtagggac                                                   20


<210> 12705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12705
cattctcagt aaactatcac                                                   20


<210> 12706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 12706
gcatattctc actcataggt                                                   20


<210> 12707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 12707
aatcacatgg acacaggaag                                                   20


<210> 12708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 12708
tcacactcta gggactgtgg                                                   20


<210> 12709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 12709
gtggggtggg gggagggggg                                                   20


<210> 12710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 12710
taatgctaga tgaccagtta                                                   20


<210> 12711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12711
aatttgaaaa agtacagatt                                                   20


<210> 12712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGGT

<400> 12712
cacctttttg tctgcatagt                                                   20


<210> 12713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 12713
ggctctgaca ccatgccggg                                                   20


<210> 12714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 12714
catcatcttt cttttcttct                                                   20


<210> 12715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 12715
cagctcctca cataagaggc                                                   20


<210> 12716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12716
ctacaaaagg taacatgttc                                                   20


<210> 12717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 12717
ctagaattat cagcttgtta                                                   20


<210> 12718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 12718
aagtaaaaaa tgacaatttt                                                   20


<210> 12719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 12719
aacctctcat agtcatccat                                                   20


<210> 12720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 12720
tcatagtcat ccatgagagt                                                   20


<210> 12721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12721
attaatgttc taataacatc                                                   20


<210> 12722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 12722
ttctaataac atctagaatg                                                   20


<210> 12723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 12723
acttttccca gacccatcag                                                   20


<210> 12724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 12724
actctttggc ccataggcta                                                   20


<210> 12725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 12725
tttggcccat aggctacaga                                                   20


<210> 12726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 12726
gtacctctcc gttagagctc                                                   20


<210> 12727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 12727
ttctatttat agagcacagg                                                   20


<210> 12728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12728
tataattctt aagagatttt                                                   20


<210> 12729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12729
tataattatt atttaatttt                                                   20


<210> 12730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12730
tatagttatt atttaatttt                                                   20


<210> 12731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12731
atttaatttt ctgaatagta                                                   20


<210> 12732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12732
gaatataatt atttaatttt                                                   20


<210> 12733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12733
tataattatt atgtaatttt                                                   20


<210> 12734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12734
tataattatt atgtaatttt                                                   20


<210> 12735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12735
agtaaataat tattaatatt                                                   20


<210> 12736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 12736
gctgcattat cccctaacaa                                                   20


<210> 12737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12737
aatgatctta gctagatctt                                                   20


<210> 12738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 12738
acttctttcc ttcaatctca                                                   20


<210> 12739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 12739
cctctcagcc ttcatacaat                                                   20


<210> 12740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 12740
attggagtta tggccttgct                                                   20


<210> 12741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 12741
cttatcattc atgtgttcac                                                   20


<210> 12742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12742
tagcacattt gatttccttc                                                   20


<210> 12743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGGT

<400> 12743
tcttccttta cttgaacatt                                                   20


<210> 12744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 12744
tttacttgaa cattaggggt                                                   20


<210> 12745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 12745
cttgaacatt aggggtggga                                                   20


<210> 12746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 12746
ctgaggaaag ggagagagat                                                   20


<210> 12747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 12747
atgattgttt gctgtcttat                                                   20


<210> 12748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 12748
ttacaaagtt gaaatattgt                                                   20


<210> 12749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 12749
gctgacagac ttgcttaatg                                                   20


<210> 12750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12750
ccacaaacct tcaacttgta                                                   20


<210> 12751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 12751
attttgatgg aaaccaaagt                                                   20


<210> 12752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12752
agttaggata aaggttttta                                                   20


<210> 12753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 12753
aaagaatgta gtgaaaaata                                                   20


<210> 12754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 12754
ttcatataca cattcaaaag                                                   20


<210> 12755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 12755
taggatgatt ctgaaaggta                                                   20


<210> 12756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 12756
actacttggt acagactcaa                                                   20


<210> 12757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12757
gtccacacaa gaacgtttac                                                   20


<210> 12758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12758
cacaacctca ttactcacca                                                   20


<210> 12759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 12759
cattactcac caatgaataa                                                   20


<210> 12760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 12760
accaatgaat aaatggataa                                                   20


<210> 12761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 12761
aataaatgga taaaggaatg                                                   20


<210> 12762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12762
gaatgtggga tattcaaaca                                                   20


<210> 12763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 12763
gtataggtac atgttacaac                                                   20


<210> 12764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 12764
attccatctt atgaaatgtc                                                   20


<210> 12765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 12765
aaatccccag aaacaaaatg                                                   20


<210> 12766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 12766
agagtatttt ttgtcagagg                                                   20


<210> 12767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 12767
ggttatgtgg ttaatggtta                                                   20


<210> 12768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 12768
aaagagtatg gggcttcttt                                                   20


<210> 12769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 12769
tgtgaacata ctaaaaacca                                                   20


<210> 12770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12770
tatatcttaa taaaactact                                                   20


<210> 12771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12771
aactactatg aatatgcatt                                                   20


<210> 12772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 12772
atgaatatgc attaagaatt                                                   20


<210> 12773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 12773
aaatatgtga aaattgtcct                                                   20


<210> 12774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12774
agtaaaaagg aaacaaatca                                                   20


<210> 12775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CGGGAT

<400> 12775
aaatcataaa ggtgagaaga                                                   20


<210> 12776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 12776
gctcttgaag aaaagttggc                                                   20


<210> 12777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 12777
gtagattcta cattcaactg                                                   20


<210> 12778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12778
tggagggtac catctctttc                                                   20


<210> 12779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 12779
gcacatgctc aacacagctc                                                   20


<210> 12780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 12780
atatgaaaaa agcagaggca                                                   20


<210> 12781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 12781
agagcagctt tagttggcat                                                   20


<210> 12782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 12782
aagttattgt accaggccag                                                   20


<210> 12783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 12783
gtggcaagat gataggctga                                                   20


<210> 12784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 12784
tttcctcttc ccttagtctt                                                   20


<210> 12785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 12785
cttctggata aacaggccac                                                   20


<210> 12786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 12786
ttaagatttg agatttctgg                                                   20


<210> 12787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12787
acattctaat aaaagtgaaa                                                   20


<210> 12788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 12788
aatgaatact tatttaatgt                                                   20


<210> 12789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12789
aggcaaaatc gaaaaagata                                                   20


<210> 12790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12790
gatgaagtgc ttttccttta                                                   20


<210> 12791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 12791
gggaaatcag tgttgcctgt                                                   20


<210> 12792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 12792
taataaataa tgtgtactgt                                                   20


<210> 12793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 12793
ctgctcggga ggctgaggca                                                   20


<210> 12794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 12794
ataaagtgta caaacttttt                                                   20


<210> 12795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 12795
ctatcaaaag ccttaaacac                                                   20


<210> 12796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 12796
tgccaaataa ttttccttct                                                   20


<210> 12797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 12797
caatccaaaa tcctaacagt                                                   20


<210> 12798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12798
gggttacact aaatgaagta                                                   20


<210> 12799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12799
gagcgttcaa agactattta                                                   20


<210> 12800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12800
aagactattt aatgaattaa                                                   20


<210> 12801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 12801
aaaatataat gcataataag                                                   20


<210> 12802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 12802
ttagccctag ttaagagatt                                                   20


<210> 12803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12803
tactatgatt gtatcttctt                                                   20


<210> 12804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 12804
tcaccattaa tctcatatta                                                   20


<210> 12805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12805
gcaactacta aaattaaaaa                                                   20


<210> 12806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 12806
ttatctatgc ttatccatct                                                   20


<210> 12807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 12807
acagtctaga acactcatct                                                   20


<210> 12808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12808
gaacactcat ctgagaatgt                                                   20


<210> 12809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 12809
gaaaacaagt tgattaatcc                                                   20


<210> 12810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 12810
tctctatgtt aaatatgtag                                                   20


<210> 12811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 12811
tatctccaag ctatcaccaa                                                   20


<210> 12812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 12812
attaattaag gtaggactcc                                                   20


<210> 12813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 12813
atgtccattt tagctagaac                                                   20


<210> 12814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 12814
cattttagct agaaccaggg                                                   20


<210> 12815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 12815
gtcatccctc tctttcaaga                                                   20


<210> 12816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12816
ataaatatta atagattatc                                                   20


<210> 12817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 12817
aaaaaaaaaa gcaaacattg                                                   20


<210> 12818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 12818
cctagagaaa tttgaggaga                                                   20


<210> 12819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 12819
caaaaacaac aacatcaatt                                                   20


<210> 12820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12820
tgtgaaacaa aaaatttcag                                                   20


<210> 12821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 12821
acccaaaagg ggcactttac                                                   20


<210> 12822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 12822
tatgtatatg taaaaatgca                                                   20


<210> 12823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 12823
gatttttcta tatattttag                                                   20


<210> 12824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 12824
aaaataaaac ttagaagata                                                   20


<210> 12825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 12825
gtaatggcag aaaattcacc                                                   20


<210> 12826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12826
aaataagata actaactaaa                                                   20


<210> 12827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 12827
gtgtgatgag agaaaatatt                                                   20


<210> 12828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 12828
tctttttttt ttaagttact                                                   20


<210> 12829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12829
aaaagtactt ctaaaacaca                                                   20


<210> 12830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 12830
caagatgttt cacaaatagt                                                   20


<210> 12831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 12831
atagtgtgaa taaaagcaaa                                                   20


<210> 12832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 12832
aatagccata ttgtccaaat                                                   20


<210> 12833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12833
gcatgaactt gaacaactgg                                                   20


<210> 12834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 12834
actggtagaa ttgaagcaga                                                   20


<210> 12835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 12835
ttgaagcaga gaggatccac                                                   20


<210> 12836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 12836
ttgatgtgtt cttcaagtag                                                   20


<210> 12837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 12837
tgttcttcaa gtagcagagt                                                   20


<210> 12838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 12838
tattatcagt gtaaaagtaa                                                   20


<210> 12839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGAT

<400> 12839
acaaaaattg agaggtagag                                                   20


<210> 12840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12840
aaaggtataa atccaaccca                                                   20


<210> 12841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 12841
gaaatgaaaa cataactgct                                                   20


<210> 12842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 12842
aacataactg cttggaattt                                                   20


<210> 12843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 12843
tccctagata atggctttaa                                                   20


<210> 12844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 12844
agggataaag caaaaattgt                                                   20


<210> 12845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12845
cttctacttt ctctgcttag                                                   20


<210> 12846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 12846
gatgaatact gaacacttca                                                   20


<210> 12847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12847
tgctaccaat ggctggcttg                                                   20


<210> 12848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 12848
catttgtctc tatggttgtc                                                   20


<210> 12849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 12849
gttgtcaaga gtgtatatat                                                   20


<210> 12850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 12850
actccactgt ggctattgac                                                   20


<210> 12851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 12851
tgttaaatca aaaatatcag                                                   20


<210> 12852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 12852
ttcaaaaagt agaaaagttt                                                   20


<210> 12853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12853
ttttgtttgg tttgaagaca                                                   20


<210> 12854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 12854
ttaactattt taaaattgga                                                   20


<210> 12855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GCGGGT

<400> 12855
caacattttc ggaggccaag                                                   20


<210> 12856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 12856
attttcggag gccaaggcgg                                                   20


<210> 12857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 12857
cgggtgaatc acttgagggc                                                   20


<210> 12858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 12858
acctgtagtc tcagctgctt                                                   20


<210> 12859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 12859
cttgagagta gctaaggtgg                                                   20


<210> 12860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 12860
atcacctgag cctggggagg                                                   20


<210> 12861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 12861
tcacaccact gcggtccagc                                                   20


<210> 12862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CCGAGT

<400> 12862
aacaacacat attttgaact                                                   20


<210> 12863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 12863
ttatgttcaa ttaaagaaag                                                   20


<210> 12864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 12864
tcaattaaag aaagaagagt                                                   20


<210> 12865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12865
agttggaatg aggggaaaaa                                                   20


<210> 12866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 12866
aaggaagatg ataaaccaaa                                                   20


<210> 12867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 12867
aggcatgcag tgctcctcct                                                   20


<210> 12868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 12868
cttgatgctg taaaataatc                                                   20


<210> 12869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 12869
acgctgatct tccaactttc                                                   20


<210> 12870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 12870
taaaaaaaat ttcattttat                                                   20


<210> 12871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12871
tccatttgat ccaatgtaaa                                                   20


<210> 12872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 12872
aagattccta gtttgaaaaa                                                   20


<210> 12873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 12873
gagttaataa tcatgctccg                                                   20


<210> 12874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 12874
tatataaagt gcttaacagg                                                   20


<210> 12875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 12875
ttctatttta attccttgct                                                   20


<210> 12876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 12876
atatattaat tatattaaat                                                   20


<210> 12877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 12877
atgaggatat ttccatttat                                                   20


<210> 12878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 12878
tattaaacag agatttagtt                                                   20


<210> 12879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 12879
cagagattta gtttagagta                                                   20


<210> 12880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 12880
aagttcagga gctagaaagc                                                   20


<210> 12881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 12881
ggagctagaa agcctgggtt                                                   20


<210> 12882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 12882
gaaagcctgg gttttgaata                                                   20


<210> 12883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 12883
aatgtaattt taaacaatac                                                   20


<210> 12884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12884
aaacaataca agagtatccc                                                   20


<210> 12885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 12885
gaatgactgt tgattgctca                                                   20


<210> 12886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 12886
actgttgatt gctcaaagga                                                   20


<210> 12887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 12887
ctcaaaggat tgggtcactg                                                   20


<210> 12888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 12888
acttttttct tttttattca                                                   20


<210> 12889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 12889
attcattgaa tattgctgaa                                                   20


<210> 12890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 12890
tcattaatgt aatctctgaa                                                   20


<210> 12891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12891
gtaatctctg aacagaatac                                                   20


<210> 12892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 12892
aagaaatatt acagtctctc                                                   20


<210> 12893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 12893
cttcacatag ggaaaatcta                                                   20


<210> 12894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 12894
tctataggat gaggtgggaa                                                   20


<210> 12895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 12895
aataactaaa aggaaaaaat                                                   20


<210> 12896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 12896
caattctatt gtggctcagt                                                   20


<210> 12897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 12897
tgaaagctat atttatttaa                                                   20


<210> 12898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 12898
tactcaggag gctgaggcag                                                   20


<210> 12899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12899
tttggaagat ctgccaaaat                                                   20


<210> 12900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 12900
ctgccaaaat ctgaatgaga                                                   20


<210> 12901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12901
aaagcattct caaggcacca                                                   20


<210> 12902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 12902
taccattgat actatgtgat                                                   20


<210> 12903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 12903
gttaaatgta atgtggtagc                                                   20


<210> 12904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12904
tagtgaaaaa ctaaggaact                                                   20


<210> 12905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 12905
aaaaactaag gaactctgaa                                                   20


<210> 12906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 12906
actgttaata acaggggaaa                                                   20


<210> 12907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 12907
ataacagggg aaactggatg                                                   20


<210> 12908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12908
gcaaaaggaa atcacagatg                                                   20


<210> 12909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 12909
ataaaggtaa taatagctca                                                   20


<210> 12910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 12910
gtaataatag ctcagtgaat                                                   20


<210> 12911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12911
ttgaaccact tttaattaaa                                                   20


<210> 12912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 12912
cttaaagtaa tcatgcctgg                                                   20


<210> 12913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 12913
ttttctataa atgcactctc                                                   20


<210> 12914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 12914
taaatgcact ctcctgggtc                                                   20


<210> 12915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 12915
ttataaacat agaactaaac                                                   20


<210> 12916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 12916
ctaaactgga gtcacaatgt                                                   20


<210> 12917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 12917
tctgagtcct aattatactt                                                   20


<210> 12918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 12918
ctaaaaaaat acacttatga                                                   20


<210> 12919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12919
aatctgtgtg tattttcttt                                                   20


<210> 12920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 12920
acagctccac tctggctgac                                                   20


<210> 12921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 12921
gaaaacagaa aaatttccag                                                   20


<210> 12922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 12922
tcttggcacc aagaaaatat                                                   20


<210> 12923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 12923
ttcctacacc tggcctccga                                                   20


<210> 12924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 12924
taagaagtac aatttagtca                                                   20


<210> 12925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 12925
aagtcaaagg tgcgaaacga                                                   20


<210> 12926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 12926
gtgcgaaacg attgaatctg                                                   20


<210> 12927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 12927
tatccattcc tatgtgctcc                                                   20


<210> 12928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 12928
ctatgtgctc cttgaattat                                                   20


<210> 12929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 12929
gacagctcta ccctagctgt                                                   20


<210> 12930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 12930
aaatttgatt caatccttgg                                                   20


<210> 12931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 12931
acagcattta tgttccaagc                                                   20


<210> 12932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12932
ccaagccagg attttgtgtc                                                   20


<210> 12933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 12933
acagaaaata ccaagacagc                                                   20


<210> 12934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 12934
tttgcttaaa taacatccta                                                   20


<210> 12935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 12935
ggctgaagac tgggaccact                                                   20


<210> 12936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 12936
aacttttcat tttctgtctt                                                   20


<210> 12937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 12937
ctgtaatatg ggcagaaagt                                                   20


<210> 12938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 12938
tccttggcct cccaaagtgc                                                   20


<210> 12939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 12939
ggttgtaatt tattatattt                                                   20


<210> 12940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 12940
accaaatcta tacacttaag                                                   20


<210> 12941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 12941
cttaagtaga gtaaaaacac                                                   20


<210> 12942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12942
ctggaattga gccagccatt                                                   20


<210> 12943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12943
attgactgcc catcttcact                                                   20


<210> 12944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 12944
actaaaagac tagcatgagc                                                   20


<210> 12945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12945
tcacaattta actattgtcc                                                   20


<210> 12946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12946
agcttcattt aactaattag                                                   20


<210> 12947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 12947
ttatgtacct gggaactttt                                                   20


<210> 12948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 12948
tgacactctg gaacattaga                                                   20


<210> 12949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 12949
agagagtgaa aatattattc                                                   20


<210> 12950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 12950
aaaatattat tctagagtga                                                   20


<210> 12951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12951
catggtttgt ttcgtttgtg                                                   20


<210> 12952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 12952
aattcatcaa actatatttt                                                   20


<210> 12953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 12953
ttaactttta ttttaagttc                                                   20


<210> 12954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGGT

<400> 12954
cataggtaaa cttgtgtcat                                                   20


<210> 12955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 12955
tttctgaaaa ctcaagttga                                                   20


<210> 12956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12956
aggaaaagat cttagacaaa                                                   20


<210> 12957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12957
tggaaacaca gcaagaaatg                                                   20


<210> 12958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12958
cagcaagaaa tgaagaatat                                                   20


<210> 12959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 12959
taagtccaat ttttattttc                                                   20


<210> 12960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 12960
attattttag tctacaacat                                                   20


<210> 12961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12961
ttgtgtagaa aacaccatcc                                                   20


<210> 12962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 12962
taacttgcta gcacaattaa                                                   20


<210> 12963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 12963
aggtatacaa catgatgcta                                                   20


<210> 12964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGGT

<400> 12964
gttgtttgtt attgttgggg                                                   20


<210> 12965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 12965
attttggtca gggaaggaag                                                   20


<210> 12966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 12966
tctttggctt tgtccttcga                                                   20


<210> 12967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 12967
tattctaatt aaaaatttta                                                   20


<210> 12968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 12968
aatcataact tacttgtatt                                                   20


<210> 12969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 12969
tctttctgtt ttcttgaaaa                                                   20


<210> 12970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12970
gaaaattgaa tattgtacac                                                   20


<210> 12971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 12971
tcagatgatc aggcattagt                                                   20


<210> 12972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 12972
gcattagtta gagtctcata                                                   20


<210> 12973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 12973
aataaagctt gcacttctct                                                   20


<210> 12974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGAT

<400> 12974
cagtatctgt cactggccca                                                   20


<210> 12975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 12975
tataaacaga tccaggtttt                                                   20


<210> 12976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 12976
aaagacagat taatataaaa                                                   20


<210> 12977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 12977
tagtctttct tttaccacaa                                                   20


<210> 12978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 12978
tgatagttga gcaaatttct                                                   20


<210> 12979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 12979
ccatcaagtt tctttcacat                                                   20


<210> 12980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 12980
cctcaatgta gtgatgtatg                                                   20


<210> 12981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 12981
gattcactct tctttataaa                                                   20


<210> 12982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12982
actggattat tacacaatcc                                                   20


<210> 12983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 12983
atttaatagt gctataagag                                                   20


<210> 12984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12984
ataaaaagtc aaaaatgaca                                                   20


<210> 12985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12985
atccaatctt ccttcttatc                                                   20


<210> 12986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 12986
cccattgtgt gtagtggtga                                                   20


<210> 12987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 12987
catctcctaa gcttattcaa                                                   20


<210> 12988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 12988
tgccctttac tttgaacttg                                                   20


<210> 12989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 12989
tttattgaaa ttcccttgtg                                                   20


<210> 12990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 12990
gggtctatgt acagctatag                                                   20


<210> 12991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 12991
gtgaccagta gtctagccag                                                   20


<210> 12992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 12992
tagtttccca aagccttcca                                                   20


<210> 12993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 12993
caaagccttc caatgaatgc                                                   20


<210> 12994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 12994
aagtgattaa agcatttctt                                                   20


<210> 12995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 12995
cataatgcag tctgtaaatg                                                   20


<210> 12996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12996
caagaaaata tggcaaatcc                                                   20


<210> 12997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 12997
agttattaaa taataattgt                                                   20


<210> 12998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 12998
tctaaaccag tggtcctcaa                                                   20


<210> 12999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 12999
aattcttccc tacctccagg                                                   20


<210> 13000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 13000
ctacctccag gtggagttac                                                   20


<210> 13001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 13001
gagttaccag agttagcaaa                                                   20


<210> 13002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 13002
gaatacacag tcagttaaat                                                   20


<210> 13003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 13003
attaacagct ccttgttttg                                                   20


<210> 13004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 13004
acttgttttt ttttattttt                                                   20


<210> 13005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 13005
tgacaaaaca gaacattgtc                                                   20


<210> 13006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 13006
atgaattttt attcccttct                                                   20


<210> 13007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 13007
taatttctcc tgttccatta                                                   20


<210> 13008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 13008
ttaaaggatc aaattcttca                                                   20


<210> 13009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 13009
taaaacagcc ttggcataca                                                   20


<210> 13010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 13010
aatcctattg ctaaaagata                                                   20


<210> 13011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 13011
aaataagtag tctttactca                                                   20


<210> 13012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 13012
gggttatttt aaaagtcagc                                                   20


<210> 13013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 13013
aatttgtgag accttttctt                                                   20


<210> 13014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 13014
ttcggtgctt taaataaact                                                   20


<210> 13015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 13015
gcatctatta aagagagcca                                                   20


<210> 13016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ACGAAT

<400> 13016
atgtgaaaga actgaaaata                                                   20


<210> 13017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 13017
ttacaaaaat tcttcattag                                                   20


<210> 13018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 13018
cttcattagt agagtctgaa                                                   20


<210> 13019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 13019
gaacagaata aatgctgaaa                                                   20


<210> 13020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 13020
gctgtttgag cagcgtcatg                                                   20


<210> 13021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 13021
tatgactact aactcaatca                                                   20


<210> 13022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ACGAGT

<400> 13022
ttttatgaga aaattattat                                                   20


<210> 13023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 13023
gaaaattatt atacgagtaa                                                   20


<210> 13024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 13024
gtaatctctg taacagtaaa                                                   20


<210> 13025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 13025
aattatttta tcttcttcat                                                   20


<210> 13026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 13026
gctgcacaaa gagcttcaaa                                                   20


<210> 13027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 13027
ttacttgcat tttgacattt                                                   20


<210> 13028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 13028
tacttctaca caaataaaaa                                                   20


<210> 13029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 13029
tggatattag taattgaccc                                                   20


<210> 13030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 13030
tgacccagga attgaaaaga                                                   20


<210> 13031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 13031
actcataact aaacataaac                                                   20


<210> 13032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 13032
aacaagagtt gagccaatga                                                   20


<210> 13033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 13033
acagtaaatt gaactaaata                                                   20


<210> 13034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 13034
ataaggtttg gggaaatgtg                                                   20


<210> 13035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 13035
agctgtgtta gtgtggacac                                                   20


<210> 13036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 13036
aattttggaa acatggtcac                                                   20


<210> 13037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 13037
accatagggg caggcactga                                                   20


<210> 13038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 13038
acagggtgat gttcgggact                                                   20


<210> 13039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 13039
actttcagaa gcatagttac                                                   20


<210> 13040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 13040
attttcagaa acatggccac                                                   20


<210> 13041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 13041
agaaacatgg ccactggaat                                                   20


<210> 13042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 13042
tcagagcctg tgtactgatt                                                   20


<210> 13043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 13043
aagaccattc ttttcctttc                                                   20


<210> 13044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 13044
aagcacagtc tgagcatgta                                                   20


<210> 13045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 13045
tttcttgtca ttatttccta                                                   20


<210> 13046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 13046
tcattatttc ctaatgaatg                                                   20


<210> 13047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 13047
gcagaataac aacaattaca                                                   20


<210> 13048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 13048
agatgattta aagtatacgg                                                   20


<210> 13049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 13049
tttaaagtat acggtaggat                                                   20


<210> 13050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 13050
ttagccaaac ctgctagaaa                                                   20


<210> 13051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 13051
aaacctgcta gaaagaggat                                                   20


<210> 13052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 13052
ctgtcttgac aaagccaata                                                   20


<210> 13053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 13053
tcatgggaac atggaggaag                                                   20


<210> 13054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 13054
gtgcttgcta tggacacctg                                                   20


<210> 13055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 13055
gaggctgcta aagttcctat                                                   20


<210> 13056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 13056
ctttttccat ttaacaatgc                                                   20


<210> 13057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 13057
taaacggcct gagaggctgg                                                   20


<210> 13058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 13058
cttttatagt acacttaata                                                   20


<210> 13059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 13059
cttaataaag gatacctgtg                                                   20


<210> 13060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGGT

<400> 13060
acaaagaaag tggagagaaa                                                   20


<210> 13061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 13061
ctcacttttc acatagtcta                                                   20


<210> 13062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 13062
gcagaaagat cggttaccaa                                                   20


<210> 13063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGGT

<400> 13063
ataaaactga tatgattggt                                                   20


<210> 13064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CGGGAT

<400> 13064
ctggaaatgg cagttgaact                                                   20


<210> 13065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 13065
ttcttatgag aggaaactag                                                   20


<210> 13066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 13066
ctggaactta aaatgggagg                                                   20


<210> 13067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 13067
tttggagaca ccagcatata                                                   20


<210> 13068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 13068
agagtatttt gacattgccc                                                   20


<210> 13069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 13069
acaaaacatg gcaaaacagc                                                   20


<210> 13070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGGT

<400> 13070
aaaagtacct tggaaacaca                                                   20


<210> 13071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 13071
ggtataggaa agaaggaaag                                                   20


<210> 13072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 13072
ggaaagaagg aaagttgagt                                                   20


<210> 13073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 13073
gttgagttgg aattcagcag                                                   20


<210> 13074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 13074
tcagtttact catcggtaaa                                                   20


<210> 13075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 13075
atcggtaaaa tgagtatgaa                                                   20


<210> 13076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 13076
aaatgagtat gaaaaggatt                                                   20


<210> 13077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 13077
aaaggatttt gaatatttaa                                                   20


<210> 13078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 13078
gttaatgcat ataaacactc                                                   20


<210> 13079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 13079
tattatcatt attaggcagg                                                   20


<210> 13080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 13080
ctacttggca gcactcttcc                                                   20


<210> 13081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 13081
aaaccagagc tttcaaacgg                                                   20


<210> 13082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 13082
gccaggcatt ctccttgtat                                                   20


<210> 13083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 13083
ggtccacatt gagcagttgt                                                   20


<210> 13084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 13084
aaagggacat gcccacttac                                                   20


<210> 13085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGGT

<400> 13085
tacaggagtc actgcattaa                                                   20


<210> 13086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 13086
caccagtatg atattactat                                                   20


<210> 13087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 13087
ttcgtgacct gacaattggg                                                   20


<210> 13088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 13088
aatacaaatc agttattttg                                                   20


<210> 13089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 13089
tttgtagaat gcgtctcaac                                                   20


<210> 13090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 13090
tgcgtctcaa cttgggttca                                                   20


<210> 13091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 13091
ggaaactaaa gcgttatcta                                                   20


<210> 13092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 13092
acagctgtgt gtagcagagc                                                   20


<210> 13093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 13093
aaaaaagata acattagagg                                                   20


<210> 13094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 13094
aaatgcagaa atacatggct                                                   20


<210> 13095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 13095
tgttgcaaag gtcttggcat                                                   20


<210> 13096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 13096
tttggcttta ttcagcagac                                                   20


<210> 13097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 13097
tgagtttaga aattcaatca                                                   20


<210> 13098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 13098
tatcaacagc aacataattt                                                   20


<210> 13099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 13099
gggaaagaca tgcatgttct                                                   20


<210> 13100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 13100
gcatgttctt agaattttgt                                                   20


<210> 13101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 13101
tagaattttg ttagaatgta                                                   20


<210> 13102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 13102
gactccctct gttaactata                                                   20


<210> 13103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 13103
actataatga atttaggaag                                                   20


<210> 13104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 13104
atatttaaat taacaaaaac                                                   20


<210> 13105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 13105
aaatgtagca cttcaaggag                                                   20


<210> 13106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 13106
aatagatgag aaccttagtg                                                   20


<210> 13107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 13107
gagaacctta gtgtagaata                                                   20


<210> 13108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 13108
tttaccactc ttgtatgaac                                                   20


<210> 13109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ACGGGT

<400> 13109
ttcactggtg aggaagttac                                                   20


<210> 13110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGAT

<400> 13110
cgggtagtct gttagaaaga                                                   20


<210> 13111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 13111
aggcaggaca agcacctggc                                                   20


<210> 13112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 13112
aaccagtctc cttaatgaaa                                                   20


<210> 13113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 13113
ctcaaataac acatcttggg                                                   20


<210> 13114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 13114
atttatatcg actatttgac                                                   20


<210> 13115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 13115
ctactactga ttcttggttt                                                   20


<210> 13116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 13116
ctcactgcag cctccacctc                                                   20


<210> 13117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 13117
ttgtctattt tttatagaaa                                                   20


<210> 13118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 13118
acctcagcct cccaaagtgc                                                   20


<210> 13119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 13119
ttcatgtaca aatatatgcc                                                   20


<210> 13120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 13120
tttaactatc atgtatgtaa                                                   20


<210> 13121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 13121
caaatggaaa tttcacattc                                                   20


<210> 13122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 13122
catatctata taatgacatg                                                   20


<210> 13123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 13123
cagaagtcag gctttgagct                                                   20


<210> 13124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 13124
aatttgatag aagacaatga                                                   20


<210> 13125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 13125
caatatgcct aaatatgtac                                                   20


<210> 13126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 13126
ctccacaaag agacactgct                                                   20


<210> 13127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 13127
aaacaaacta cagctgctct                                                   20


<210> 13128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 13128
agaagaaagg aaaaaggaag                                                   20


<210> 13129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 13129
aaggtttcgg ttttaacctt                                                   20


<210> 13130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 13130
ggttttaacc ttaagaatac                                                   20


<210> 13131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 13131
ttgttttgta agcatacttg                                                   20


<210> 13132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 13132
gaataatgtc aatacatagg                                                   20


<210> 13133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 13133
gcatttactt taaaatcgtt                                                   20


<210> 13134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 13134
taatagaacc aatctagtca                                                   20


<210> 13135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 13135
ttttttaaag attaaaccat                                                   20


<210> 13136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 13136
aaaattttct acctcacgtt                                                   20


<210> 13137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 13137
tttctacctc acgtttagaa                                                   20


<210> 13138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 13138
aataaaagat ctcccaataa                                                   20


<210> 13139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 13139
aatctatcat taccttgatc                                                   20


<210> 13140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 13140
aaattgaaac ttttaaagat                                                   20


<210> 13141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 13141
gcaaaaacgt ttttagcaca                                                   20


<210> 13142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 13142
tttttagcac atagagtgca                                                   20


<210> 13143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 13143
tagatttgtg ataacctatt                                                   20


<210> 13144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 13144
tgttgatatt ttatagaact                                                   20


<210> 13145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 13145
taaaatattt attttatttc                                                   20


<210> 13146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 13146
aacctttggt ttgaggacta                                                   20


<210> 13147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 13147
actatgagaa agaacctgat                                                   20


<210> 13148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 13148
cagcactttg ggaggccgag                                                   20


<210> 13149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 13149
actttgggag gccgagggga                                                   20


<210> 13150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 13150
agctactcaa gaggctgaga                                                   20


<210> 13151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGAT

<400> 13151
ggatgtttgc ttgagcccct                                                   20


<210> 13152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 13152
actgcactca gcctgggaga                                                   20


<210> 13153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 13153
tagatgcttt ataatgtaaa                                                   20


<210> 13154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 13154
ttacttgtga gataacagat                                                   20


<210> 13155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 13155
gataacagat taggatcatg                                                   20


<210> 13156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 13156
gaaatgctaa gtctttttac                                                   20


<210> 13157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 13157
attgatcaca tcacattact                                                   20


<210> 13158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 13158
gataccatta actatcacct                                                   20


<210> 13159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 13159
actatcacct gggagtcaac                                                   20


<210> 13160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 13160
tccttcaagt catccgccat                                                   20


<210> 13161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 13161
ttagaattgt ttaaccttgc                                                   20


<210> 13162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 13162
cagtgtaaga cagaaagcat                                                   20


<210> 13163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 13163
agatttgagc tgattttatt                                                   20


<210> 13164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 13164
gaatataccc caattactcc                                                   20


<210> 13165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 13165
tattacagcc tgtgtataag                                                   20


<210> 13166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 13166
tgggtatcta gtggcttcag                                                   20


<210> 13167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 13167
tttaactatc atccatgtgg                                                   20


<210> 13168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 13168
aatgactgct atataatgcc                                                   20


<210> 13169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 13169
actgctatat aatgccctga                                                   20


<210> 13170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 13170
ctatataatg ccctgaatga                                                   20


<210> 13171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 13171
ctgaatgaat gaatcaatca                                                   20


<210> 13172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 13172
tggtactcaa tgttctttca                                                   20


<210> 13173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 13173
tttcacagaa tctctatttt                                                   20


<210> 13174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 13174
acatcatgac aaaattagta                                                   20


<210> 13175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 13175
tatcctcatt ttaattcatg                                                   20


<210> 13176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 13176
atgttcattt gagatagatc                                                   20


<210> 13177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGGT

<400> 13177
aacaaaaaaa agtagggaaa                                                   20


<210> 13178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 13178
tctttttatt ttcatcccaa                                                   20


<210> 13179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 13179
ccaatattac tgaaaaacaa                                                   20


<210> 13180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 13180
aactgaatct agcttcctcc                                                   20


<210> 13181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 13181
ctagcttcct ccctgaattt                                                   20


<210> 13182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 13182
ttgaaacaac aaagatggag                                                   20


<210> 13183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 13183
gaagaatacc ttactgaaat                                                   20


<210> 13184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 13184
accttactga aatatgaata                                                   20


<210> 13185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 13185
tctcctgctc ctctgggctt                                                   20


<210> 13186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 13186
ttgtattacc acttcgtgaa                                                   20


<210> 13187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 13187
gagtaaacaa gcaagaaaac                                                   20


<210> 13188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 13188
aagaccatag gccataaaaa                                                   20


<210> 13189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 13189
catacttgtc ttggaaaagc                                                   20


<210> 13190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 13190
tgctattgtt tgacaccaaa                                                   20


<210> 13191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 13191
atcattgttc tctctaaagc                                                   20


<210> 13192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 13192
tctaaagcgt gggttcaggt                                                   20


<210> 13193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 13193
ctagacagaa ctctgaagag                                                   20


<210> 13194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 13194
tcaaatgaaa aaataaaata                                                   20


<210> 13195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 13195
taaaataggg aattgggact                                                   20


<210> 13196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 13196
atagggaatt gggactggga                                                   20


<210> 13197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 13197
tacagtgatg ctgaactaat                                                   20


<210> 13198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 13198
gtgtttagag agaacataag                                                   20


<210> 13199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 13199
aacataagaa gagtaaattt                                                   20


<210> 13200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 13200
tctttcttct tattctcctt                                                   20


<210> 13201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 13201
ctttgggatc ttttattttt                                                   20


<210> 13202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 13202
aggacatcaa gtaattattt                                                   20


<210> 13203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 13203
atagcattgt cctaaatcca                                                   20


<210> 13204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 13204
gtcctaaatc cagagggttc                                                   20


<210> 13205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGAT

<400> 13205
tagaaagctc ttgacaccca                                                   20


<210> 13206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 13206
cctggttggg gaggaaagcc                                                   20


<210> 13207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 13207
gccttgagtt ctgtgctatt                                                   20


<210> 13208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 13208
ctactattcc atcatttttc                                                   20


<210> 13209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 13209
caggaagtgt ctaaattacc                                                   20


<210> 13210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 13210
ggcatttaaa gttcatgcca                                                   20


<210> 13211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 13211
aaggtcatga agagacaaag                                                   20


<210> 13212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 13212
aatatttaaa aaaaaacaca                                                   20


<210> 13213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CGGAGT

<400> 13213
taaaaaaaaa cacataggat                                                   20


<210> 13214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 13214
tacatggtgt ctagtcatat                                                   20


<210> 13215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 13215
ctccagagag gaagaggcaa                                                   20


<210> 13216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 13216
gtacattttt cctacaaact                                                   20


<210> 13217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 13217
ccatttactc cctgggaact                                                   20


<210> 13218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 13218
tactccctgg gaactcagaa                                                   20


<210> 13219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 13219
ctctcatttt gtcttatcca                                                   20


<210> 13220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 13220
cacagaatat atagtactgt                                                   20


<210> 13221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 13221
agtggcttct caatagctta                                                   20


<210> 13222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 13222
cttccctcag gagccagtcc                                                   20


<210> 13223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CCGGGT

<400> 13223
ttaaacctcc aaagtagtgg                                                   20


<210> 13224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 13224
tcctcggaag gctgaggcag                                                   20


<210> 13225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 13225
gagatcacgc cattgcactt                                                   20


<210> 13226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 13226
tactcccata tttagcccaa                                                   20


<210> 13227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 13227
aggaaacaga aaaagtgaga                                                   20


<210> 13228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 13228
aaaagtcaca aagttatgta                                                   20


<210> 13229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 13229
tccacttcat tttgcaattt                                                   20


<210> 13230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 13230
gtactgttaa ttctgaaaat                                                   20


<210> 13231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 13231
agggcaatgc attataaggc                                                   20


<210> 13232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 13232
actttggaag gccgaggcag                                                   20


<210> 13233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 13233
caggtggatc acctgaagtc                                                   20


<210> 13234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 13234
tactcaggag gctgaggcag                                                   20


<210> 13235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 13235
tgcactccag cctgggcaac                                                   20


<210> 13236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 13236
tatgattcta ttattcctgc                                                   20


<210> 13237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGAT

<400> 13237
gagattatca gaaaaactat                                                   20


<210> 13238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 13238
aactatgggg atgcccctcc                                                   20


<210> 13239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 13239
ccttcatctc tgctgatttt                                                   20


<210> 13240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 13240
ttttaggaat tcagaaattt                                                   20


<210> 13241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 13241
gaagttttga tttggggaag                                                   20


<210> 13242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGGT

<400> 13242
gaagaggaat tagtatgcat                                                   20


<210> 13243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 13243
ccactattat cctagacaca                                                   20


<210> 13244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 13244
gacacattga attgagctct                                                   20


<210> 13245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 13245
ttagaatttt gtctgtaaat                                                   20


<210> 13246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 13246
atcaaaagat ggttataact                                                   20


<210> 13247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 13247
tataactaag agtaagaaac                                                   20


<210> 13248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GCGAAT

<400> 13248
atttcaacta caaatataaa                                                   20


<210> 13249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 13249
tttaacaaaa aaagcttttt                                                   20


<210> 13250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 13250
aaaagctttt tcagagtgct                                                   20


<210> 13251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 13251
gacacaaagg cttccaaggg                                                   20


<210> 13252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 13252
agcatgaaaa gcctaaaaag                                                   20


<210> 13253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 13253
caaaacaaaa acccacacat                                                   20


<210> 13254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 13254
tgcttcctgc aactgagctg                                                   20


<210> 13255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 13255
gcaactgagc tgaggaattt                                                   20


<210> 13256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 13256
ttctttttca agcaaaagat                                                   20


<210> 13257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 13257
atatttaatc actttatcta                                                   20


<210> 13258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 13258
tcagagaagc agagctggtg                                                   20


<210> 13259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 13259
gctggtggag aattccctgg                                                   20


<210> 13260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 13260
tcagtctttg ctatggacaa                                                   20


<210> 13261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGGT

<400> 13261
ccatccaagt cattagtctt                                                   20


<210> 13262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 13262
caagtcatta gtcttggggg                                                   20


<210> 13263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 13263
attggaaaca aatctcatta                                                   20


<210> 13264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 13264
tcatcaacct gataccatct                                                   20


<210> 13265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 13265
agtaaaaaat gtaagtgagc                                                   20


<210> 13266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 13266
gtaagtgtgc ctattataat                                                   20


<210> 13267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 13267
tagataaatc tatactactc                                                   20


<210> 13268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 13268
ctcatggatt tatctgactt                                                   20


<210> 13269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 13269
gattaaaaat gttttctcca                                                   20


<210> 13270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 13270
tcttagttgc agtaacattg                                                   20


<210> 13271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 13271
tcaaactgaa aagtaagaca                                                   20


<210> 13272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ACGGGT

<400> 13272
ctatgagcat tcaactgaaa                                                   20


<210> 13273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 13273
ccttgttagt gctttttaac                                                   20


<210> 13274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 13274
aaaccaagat ttaaaagttc                                                   20


<210> 13275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 13275
tgggcagatc acttgaggtc                                                   20


<210> 13276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 13276
ccttcaaaaa tacaaaaata                                                   20


<210> 13277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 13277
ttgcctaaca ccaagcaagt                                                   20


<210> 13278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 13278
ctacagctcc ccactatgta                                                   20


<210> 13279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GCGGAT

<400> 13279
ctgccagcag tcccctaaat                                                   20


<210> 13280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 13280
ataaaattgt taaatgcttg                                                   20


<210> 13281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 13281
ctgatatgtg caaaaaatat                                                   20


<210> 13282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 13282
aaggttaaaa gtttggtcag                                                   20


<210> 13283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 13283
aagtttaaaa ttctctaatt                                                   20


<210> 13284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 13284
agttgcacat gtgactaatt                                                   20


<210> 13285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 13285
atttggggtt attaatatgg                                                   20


<210> 13286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 13286
tggctaattt ttttttttaa                                                   20


<210> 13287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 13287
tctctctctg tcacccaggc                                                   20


<210> 13288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 13288
cctctgcctc ttggcagcac                                                   20


<210> 13289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 13289
aaaacgtttt tatctaaaat                                                   20


<210> 13290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 13290
cattattttc ttgtttgcca                                                   20


<210> 13291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 13291
ccaagggatt gtgtgtgtgt                                                   20


<210> 13292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 13292
tgggtgtgtg tgcacacgct                                                   20


<210> 13293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 13293
actaaaactg gttttcaaaa                                                   20


<210> 13294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 13294
aatatataat tactctttaa                                                   20


<210> 13295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 13295
tttttgacag attctcagtc                                                   20


<210> 13296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 13296
ctcactataa cctctgcctc                                                   20


<210> 13297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 13297
gattctcctg cctcagcctc                                                   20


<210> 13298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 13298
ttttgtattt ttagtagcga                                                   20


<210> 13299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 13299
cagggtttca ccatgttggc                                                   20


<210> 13300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 13300
gccttggcct cccaaaatgc                                                   20


<210> 13301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 13301
gaggtttttc acacagtccc                                                   20


<210> 13302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 13302
ccctggagtc ttgtctgagg                                                   20


<210> 13303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 13303
ctcttttctt ttctcagtgt                                                   20


<210> 13304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 13304
cattcttata tttatttttg                                                   20


<210> 13305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGGT

<400> 13305
gtaactttta ttttaagttc                                                   20


<210> 13306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 13306
acacagggaa acttgtgtta                                                   20


<210> 13307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 13307
ttataagtga ggacattctc                                                   20


<210> 13308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 13308
tatttgtaag acaaatgctt                                                   20


<210> 13309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 13309
aatgcttcag agtgaaattg                                                   20


<210> 13310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CCGAAT

<400> 13310
tttgccataa taaaatattg                                                   20


<210> 13311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 13311
taacgcctac agggccatag                                                   20


<210> 13312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TCGAAT

<400> 13312
acttctccat tctttggcca                                                   20


<210> 13313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 13313
tcactttccc atttcttgta                                                   20


<210> 13314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 13314
ctctccccaa acaatgtgtc                                                   20


<210> 13315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 13315
ctttgtgagc ctaataagtg                                                   20


<210> 13316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 13316
tttatttatt tattttgaga                                                   20


<210> 13317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 13317
cgctctctca ttgcccaggc                                                   20


<210> 13318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 13318
ctcactgcaa catctgcctc                                                   20


<210> 13319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 13319
agttctcctg cctcagcctc                                                   20


<210> 13320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TCGGAT

<400> 13320
gcctcagcct cctgagtagc                                                   20


<210> 13321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 13321
atctcagctt cccaaagtgc                                                   20


<210> 13322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 13322
tttagtttgc attttctttt                                                   20


<210> 13323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 13323
tttcttttgt gagtgaggtc                                                   20


<210> 13324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 13324
gcatctacat tttaattaaa                                                   20


<210> 13325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 13325
gtacttcata agtgtgatga                                                   20


<210> 13326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 13326
tgattccact aaaatgtatc                                                   20


<210> 13327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 13327
ttaggtggca aagcagtaat                                                   20


<210> 13328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 13328
atatgtaact atgtctattt                                                   20


<210> 13329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 13329
cataaaataa cattatgtat                                                   20


<210> 13330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 13330
atttctattt ttattttcat                                                   20


<210> 13331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 13331
atcagtttaa taacttcaac                                                   20


<210> 13332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 13332
gattattaaa atattgtgat                                                   20


<210> 13333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GCGGAT

<400> 13333
actttgggaa gccgaggcag                                                   20


<210> 13334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 13334
caggcggatc acctgaggtc                                                   20


<210> 13335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 13335
gaactgcttg aacccgggag                                                   20


<210> 13336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 13336
ggcaccaggc agacttaggt                                                   20


<210> 13337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 13337
tgtcttataa agttatcatg                                                   20


<210> 13338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 13338
aaatttttaa ataataagcc                                                   20


<210> 13339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 13339
aaccttacga aaatcttatg                                                   20


<210> 13340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 13340
agttgttaaa ttcatggctc                                                   20


<210> 13341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 13341
ggctccagag tgagagaggc                                                   20


<210> 13342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 13342
cttactagct tatgtccttg                                                   20


<210> 13343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 13343
ttagtggaaa aaattagaca                                                   20


<210> 13344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 13344
aagctaatgt tcttaggaac                                                   20


<210> 13345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 13345
ttcttaggga gctttcaact                                                   20


<210> 13346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 13346
attagtttat tcagtgtcta                                                   20


<210> 13347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 13347
atccatcagg tttgataaat                                                   20


<210> 13348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 13348
gtggatacac tgaacacacc                                                   20


<210> 13349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 13349
agatttaata acaaaaacat                                                   20


<210> 13350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 13350
gatgaccctc taggactgag                                                   20


<210> 13351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 13351
aaaaatgaaa atgctctagc                                                   20


<210> 13352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 13352
aaatgctcta gcatgagtca                                                   20


<210> 13353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GCGGAT

<400> 13353
cagaggattt ttcattagca                                                   20


<210> 13354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 13354
tgaaatattc ctgatggggc                                                   20


<210> 13355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 13355
ttaattcaat atcaaaataa                                                   20


<210> 13356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 13356
ttttgatgaa gacattgttt                                                   20


<210> 13357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGGT

<400> 13357
aatctatatt agcaaaggaa                                                   20


<210> 13358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 13358
gaagggggta atctggtttg                                                   20


<210> 13359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 13359
agtactatgg tataaataac                                                   20


<210> 13360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 13360
aggaaccctc accataatct                                                   20


<210> 13361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 13361
taaaaatata ttcaaagata                                                   20


<210> 13362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 13362
aagggtatgg ctattttttt                                                   20


<210> 13363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 13363
gtatggctat ttttttaagg                                                   20


<210> 13364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 13364
tactttctgc cattttgggg                                                   20


<210> 13365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 13365
cagaacctca cagatataaa                                                   20


<210> 13366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 13366
ctcacagata taaataggat                                                   20


<210> 13367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 13367
taaataggat tggagtcatg                                                   20


<210> 13368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 13368
tccaaattag ataacaatca                                                   20


<210> 13369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 13369
taacaatcac aggatcacaa                                                   20


<210> 13370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 13370
cctaaacatt tgctttatct                                                   20


<210> 13371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 13371
gatcaaattt atattccaga                                                   20


<210> 13372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 13372
ttattatttt taaatttatt                                                   20


<210> 13373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 13373
tataactttg accaggaggc                                                   20


<210> 13374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 13374
tctttttatt attctaactg                                                   20


<210> 13375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 13375
gcaaaattta cttagtgacc                                                   20


<210> 13376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 13376
ctaggggact taacctccac                                                   20


<210> 13377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 13377
ctgaaaacac tttaacaaaa                                                   20


<210> 13378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 13378
agccttgtaa aatggtctgt                                                   20


<210> 13379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 13379
tggattacaa ctacagcaca                                                   20


<210> 13380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 13380
ttgtttgatt taatcatatc                                                   20


<210> 13381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 13381
atatctagga ttagaaaatg                                                   20


<210> 13382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 13382
aattcattaa ctagctaggc                                                   20


<210> 13383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 13383
caaggatatt ctttcccatc                                                   20


<210> 13384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 13384
agaacaaaac aaaatgaaat                                                   20


<210> 13385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 13385
tgaaatggaa ggcacatgtt                                                   20


<210> 13386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 13386
aaaccagatc tctggggaca                                                   20


<210> 13387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 13387
gggaaagctg gaaactctct                                                   20


<210> 13388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ACGAAT

<400> 13388
tggaaactct cttagagtct                                                   20


<210> 13389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 13389
ttagagtcta cgaattatat                                                   20


<210> 13390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 13390
gaatttttaa aaaatcacca                                                   20


<210> 13391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 13391
tgaatcacag acctaaacgt                                                   20


<210> 13392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 13392
tcaacaaaag aaaaaaagag                                                   20


<210> 13393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 13393
aaaagaaaaa aagagctgaa                                                   20


<210> 13394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 13394
tgcaaatcat atatctgata                                                   20


<210> 13395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 13395
aagcagatta aaaatgaaca                                                   20


<210> 13396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TCGGAT

<400> 13396
aaatatcact tcacacttgg                                                   20


<210> 13397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 13397
aaaggaaaag aaacattgac                                                   20


<210> 13398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 13398
aacccttgtg cattgctgat                                                   20


<210> 13399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 13399
atgatccagc aattctactt                                                   20


<210> 13400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 13400
aatactacac agccttaaaa                                                   20


<210> 13401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CCGGAT

<400> 13401
attctgatat atgctacgac                                                   20


<210> 13402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 13402
acatgaaaag acaaatgcta                                                   20


<210> 13403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 13403
ttccacttac atgaggtacc                                                   20


<210> 13404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 13404
agtcacattc atagagaaag                                                   20


<210> 13405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 13405
agaaagtaga atagtggtta                                                   20


<210> 13406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 13406
actgggtgat aggggaagag                                                   20


<210> 13407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 13407
gataggggaa gagaggagtg                                                   20


<210> 13408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CCGAGT

<400> 13408
gagtcattgt ttaatagtta                                                   20


<210> 13409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 13409
atagttaccg agtttttgtt                                                   20


<210> 13410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 13410
atgatgaaaa tgttctgaag                                                   20


<210> 13411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 13411
tggtggtgat cgtgtacaac                                                   20


<210> 13412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 13412
tttgagatcc gtaaggcaga                                                   20


<210> 13413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 13413
cccaaatagt aagaggttcc                                                   20


<210> 13414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 13414
caatccatta cagacaggaa                                                   20


<210> 13415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 13415
caattgctgt tttttgtgac                                                   20


<210> 13416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 13416
gcatatctta tggtacaatg                                                   20


<210> 13417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GCGAAT

<400> 13417
tggtacaatg atggatagtg                                                   20


<210> 13418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 13418
aagaaagagg gaaggaaaga                                                   20


<210> 13419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 13419
aattgctttt aaattccagg                                                   20


<210> 13420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 13420
ggaagagtat aaatgctgag                                                   20


<210> 13421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 13421
atgctgagag gagtgaggtt                                                   20


<210> 13422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 13422
cagccgctta ccactgccct                                                   20


<210> 13423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 13423
tcaatggcac caataccaac                                                   20


<210> 13424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CCGGAT

<400> 13424
cattttggag gccaactaga                                                   20


<210> 13425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 13425
ttttatctgt tgatgatcat                                                   20


<210> 13426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 13426
gttttcatat ttttgctatt                                                   20


<210> 13427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 13427
tgagattctg atttcaattg                                                   20


<210> 13428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 13428
aaccttaacc acttagtcta                                                   20


<210> 13429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 13429
tcccaaagta cagtatctaa                                                   20


<210> 13430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 13430
aatttaactg acttagataa                                                   20


<210> 13431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 13431
atatttgtac tcctccaata                                                   20


<210> 13432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 13432
acttctccat ctgctagctc                                                   20


<210> 13433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 13433
tccctgtttc ttctccattt                                                   20


<210> 13434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 13434
tttaattttt tttcttgaga                                                   20


<210> 13435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 13435
tctcgctctg ttgcccaggc                                                   20


<210> 13436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 13436
acaggtgctg gccaccatgc                                                   20


<210> 13437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 13437
tgtatttttt ttagtagaga                                                   20


<210> 13438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 13438
tgcctcagcc ttccaaagtg                                                   20


<210> 13439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GCGAAT

<400> 13439
ttaatgttaa aacaaaatat                                                   20


<210> 13440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 13440
cttaacacaa tatacccctc                                                   20


<210> 13441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 13441
aattttattt tagctccatt                                                   20


<210> 13442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 13442
taagggttaa acatatttga                                                   20


<210> 13443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 13443
aaccaccagg tatatctgtg                                                   20


<210> 13444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 13444
ggtatgtgca aacgtattct                                                   20


<210> 13445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 13445
attcaagttt agtaaccatt                                                   20


<210> 13446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGAT

<400> 13446
tcacctcaaa tggtggtcat                                                   20


<210> 13447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 13447
tgggcagatc acctgaggtc                                                   20


<210> 13448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 13448
tacttgggag gctgaggcag                                                   20


<210> 13449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 13449
ggctgaggca ggagaatcac                                                   20


<210> 13450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 13450
ctgcactcca gcctgggcaa                                                   20


<210> 13451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 13451
cgggcagatc acctgaactc                                                   20


<210> 13452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 13452
tactcgggag gctgaggcag                                                   20


<210> 13453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 13453
tgcactccag cctgggcaac                                                   20


<210> 13454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 13454
tcggtctcaa aaaaaaaaaa                                                   20


<210> 13455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 13455
tatttgacta agaccacata                                                   20


<210> 13456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 13456
aagtctgtca gctgatctca                                                   20


<210> 13457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 13457
accttattcc cagttgatcc                                                   20


<210> 13458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 13458
gccacttccc tttttcctac                                                   20


<210> 13459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 13459
ccatgagcca agtttgtaaa                                                   20


<210> 13460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 13460
aagtttgtaa atggggtaac                                                   20


<210> 13461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 13461
tcccataata tttacctaga                                                   20


<210> 13462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 13462
acactgtcta ttagacttga                                                   20


<210> 13463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 13463
cccaggctga tctagaactc                                                   20


<210> 13464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGAT

<400> 13464
gcctcggcct cccaaagtga                                                   20


<210> 13465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGGT

<400> 13465
tcccaaagtg atgggattgc                                                   20


<210> 13466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 13466
tccctgtttt actcatctgc                                                   20


<210> 13467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 13467
ttttactcat ctgcatggat                                                   20


<210> 13468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 13468
atatttttaa aataattaca                                                   20


<210> 13469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GCGGAT

<400> 13469
actttgggag gtcgaggcgg                                                   20


<210> 13470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 13470
ctactcggag gctgaggcag                                                   20


<210> 13471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 13471
aataaaaaat aaaaaaaaaa                                                   20


<210> 13472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAGT

<400> 13472
tttaaaaatc agataataca                                                   20


<210> 13473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 13473
atttttatta aaaatcttat                                                   20


<210> 13474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 13474
ctaatagttt gacctaaaag                                                   20


<210> 13475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 13475
aaagggcatt cattgcaggg                                                   20


<210> 13476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 13476
taacaagagg aaatcataaa                                                   20


<210> 13477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 13477
tctatagaac taaaaagata                                                   20


<210> 13478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 13478
catttttcct caccacccag                                                   20


<210> 13479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 13479
ccttccagca aggcagagga                                                   20


<210> 13480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 13480
aatgaagaaa tttcattttt                                                   20


<210> 13481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 13481
aagtattcta cccacattct                                                   20


<210> 13482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 13482
gatgtcataa tacttctgta                                                   20


<210> 13483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 13483
aagtgtgtgt gtgtgtgtgt                                                   20


<210> 13484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAGT

<400> 13484
gtgtgtgtgt gtgtgtgagt                                                   20


<210> 13485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 13485
cttccactct aataacagtg                                                   20


<210> 13486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 13486
aataacagtg atgggtcttc                                                   20


<210> 13487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 13487
gcctctctga accttcctta                                                   20


<210> 13488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 13488
ttagagaatg cttcaaatat                                                   20


<210> 13489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 13489
agcatctatg tttattttaa                                                   20


<210> 13490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 13490
caaggttatc attttagatt                                                   20


<210> 13491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 13491
tttgtggtca ctgcctttct                                                   20


<210> 13492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 13492
tcacctacac tgataaaaga                                                   20


<210> 13493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 13493
ataaaagaga gaatacatct                                                   20


<210> 13494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 13494
aatgcttgac aaataaaaaa                                                   20


<210> 13495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 13495
aatcacaaaa ttcatgtttc                                                   20


<210> 13496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 13496
gttaatatgc tttattctgg                                                   20


<210> 13497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGGT

<400> 13497
gtcaacaatg aagacatagt                                                   20


<210> 13498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 13498
agacatagtc tgggttccct                                                   20


<210> 13499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TCGAGT

<400> 13499
ctttccaaaa caaaaaaacc                                                   20


<210> 13500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAGT

<400> 13500
ttgagattta aagtttaaga                                                   20


<210> 13501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 13501
taagaaggag taagcacgca                                                   20


<210> 13502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 13502
cagcatttga aaaggcctta                                                   20


<210> 13503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 13503
caggagcacc ttaatgagaa                                                   20


<210> 13504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 13504
tggagagaag ggacagaaca                                                   20


<210> 13505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 13505
ccaatgtttg ttaggggaga                                                   20


<210> 13506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAAT

<400> 13506
ggatggtatt gctttgtata                                                   20


<210> 13507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAAT

<400> 13507
ggtattgctt tgtatagaga                                                   20


<210> 13508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 13508
gattgatatg gaggctgtgg                                                   20


<210> 13509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 13509
ggccgtgtag atacagaaaa                                                   20


<210> 13510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGAAT

<400> 13510
gtgtagatac agaaaagagg                                                   20


<210> 13511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 13511
caggctggaa agggctgaaa                                                   20


<210> 13512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 13512
atcaaaggtg atttcaatac                                                   20


<210> 13513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 13513
agataatgaa gatgggagga                                                   20


<210> 13514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 13514
tgggaggaaa gaatctgaga                                                   20


<210> 13515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 13515
attattatca ttatgacatc                                                   20


<210> 13516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 13516
cactcttttg cataactaat                                                   20


<210> 13517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 13517
ataactaata ggaatagaaa                                                   20


<210> 13518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 13518
ttttccttgc cacagagaaa                                                   20


<210> 13519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 13519
gaaccctact gattgctctt                                                   20


<210> 13520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 13520
tgagcctagc cctgcaccat                                                   20


<210> 13521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 13521
gtcactgtaa aaacacatca                                                   20


<210> 13522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 13522
atcaaatacc atattctgtc                                                   20


<210> 13523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 13523
atcatgaaaa tttgcgacac                                                   20


<210> 13524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 13524
taaatagtgg aaaaaatctg                                                   20


<210> 13525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGAT

<400> 13525
taaaatgaac agtttaataa                                                   20


<210> 13526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 13526
acagggaaga agaaatagaa                                                   20


<210> 13527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 13527
atgtaaattg ctcttaacat                                                   20


<210> 13528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 13528
aaaaaaaaaa aactaaaata                                                   20


<210> 13529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 13529
ttcttgttct gatttttgtc                                                   20


<210> 13530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGAGT

<400> 13530
ccattttttc ctaaaagtaa                                                   20


<210> 13531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 13531
aagtaaatga gtttcccaag                                                   20


<210> 13532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 13532
tgaattcgat aaaaagttaa                                                   20


<210> 13533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 13533
aaaaggattc tgcatctttt                                                   20


<210> 13534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGGT

<400> 13534
tttgtgtttg tgtgctctta                                                   20


<210> 13535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CGGGGT

<400> 13535
ttgtgtgctc ttaaggggtg                                                   20


<210> 13536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 13536
taaaaaatgt gagctgcccc                                                   20


<210> 13537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 13537
agaacctggc agcaaaccca                                                   20


<210> 13538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 13538
tctttccagg tggcgtaata                                                   20


<210> 13539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGGT

<400> 13539
agatgtgaaa atagacacag                                                   20


<210> 13540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 13540
atccccaccc agtgcacctg                                                   20


<210> 13541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CGGAAT

<400> 13541
cccagcctca gccgagctgg                                                   20


<210> 13542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CCGGGT

<400> 13542
ctccactcct cccagcgcgc                                                   20


<210> 13543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGGGT

<400> 13543
cgctaataga aggcggagga                                                   20


<210> 13544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 13544
ctgccatcca cggccaccca                                                   20


<210> 13545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 13545
tgggtggggc gtgtgtgtgt                                                   20


<210> 13546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 13546
tttcctccct tcctgctcag                                                   20


<210> 13547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 13547
tggggaccaa tggcaaagcc                                                   20


<210> 13548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 13548
ctccccgacc ttgggctctg                                                   20


<210> 13549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GGGAAT

<400> 13549
ggctctgaag agtctaggct                                                   20


<210> 13550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GCGAGT

<400> 13550
gtagggcttt gctcacaacc                                                   20


<210> 13551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 13551
atatgtatat ataaaatcaa                                                   20


<210> 13552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 13552
tttctttcga agatgcagtg                                                   20


<210> 13553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 13553
cagacctggg acccgattat                                                   20


<210> 13554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 13554
ctgaatatgc catcagtcat                                                   20


<210> 13555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 13555
tgccatcagt catatgggtt                                                   20


<210> 13556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 13556
ttttaaaaat tcattttgtg                                                   20


<210> 13557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 13557
gggaggaaga acaatggaaa                                                   20


<210> 13558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 13558
gaagaacaat ggaaacaggg                                                   20


<210> 13559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGAT

<400> 13559
tccaccaagg gaagaaatca                                                   20


<210> 13560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 13560
atcaaaggat ggccataggg                                                   20


<210> 13561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 13561
caaaagggca gaccactttg                                                   20


<210> 13562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGGT

<400> 13562
accggaagga aatcaaatcc                                                   20


<210> 13563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 13563
ttggtggtag atataggaag                                                   20


<210> 13564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 13564
aagaagagtt caactgcaat                                                   20


<210> 13565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGGGT

<400> 13565
gttcacagca aaactgaagg                                                   20


<210> 13566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 13566
cataaccgct actcccacac                                                   20


<210> 13567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 13567
ccattatcaa cattccccac                                                   20


<210> 13568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGGT

<400> 13568
caaggtctgt agttcacatt                                                   20


<210> 13569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGGGT

<400> 13569
tcatggtgtt gtccattcta                                                   20


<210> 13570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAGT

<400> 13570
tccaccatta cagtatctta                                                   20


<210> 13571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 13571
agagtaattt cagttctctc                                                   20


<210> 13572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 13572
ctttatagtt ttgccttctc                                                   20


<210> 13573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 13573
atcctatagt tgcaataata                                                   20


<210> 13574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 13574
tagctcattt ctttacagtg                                                   20


<210> 13575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 13575
tggacatgtt ttcaagtcct                                                   20


<210> 13576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 13576
aacatcaagg agcacaattg                                                   20


<210> 13577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 13577
caattgctgg atcatatggt                                                   20


<210> 13578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 13578
cattcccacc agcaatacat                                                   20


<210> 13579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 13579
aacttgatat catcagtgtt                                                   20


<210> 13580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GTGGAT

<400> 13580
tttcccctgt gatatatgat                                                   20


<210> 13581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 13581
tatatggccc atttttttca                                                   20


<210> 13582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 13582
ggttatttct tttcttgttg                                                   20


<210> 13583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 13583
tatgcctttg ctgttatatc                                                   20


<210> 13584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAGT

<400> 13584
acatatgtta gatacattct                                                   20


<210> 13585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAAT

<400> 13585
tgttagatac attcttagag                                                   20


<210> 13586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 13586
aaatcctctt ggtctgactg                                                   20


<210> 13587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGGAT

<400> 13587
tctgactgag ggatcccttg                                                   20


<210> 13588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 13588
atactacact gcacagcctt                                                   20


<210> 13589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 13589
gatggtacgt ttaaaattta                                                   20


<210> 13590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAAT

<400> 13590
ttaaaattta aagggtaggc                                                   20


<210> 13591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGAGT

<400> 13591
gatagaaaaa tgtggaaatg                                                   20


<210> 13592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CAGAAT

<400> 13592
taacatcata caatccatac                                                   20


<210> 13593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGAAT

<400> 13593
catacaatcc ataccagaat                                                   20


<210> 13594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 13594
atccatacca gaataggaat                                                   20


<210> 13595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGAT

<400> 13595
tttcccttag tgagaaataa                                                   20


<210> 13596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 13596
taaaattaat acaatactga                                                   20


<210> 13597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 13597
tttgtttttc tctaattaaa                                                   20


<210> 13598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 13598
ttattctgtt gtgaaaatag                                                   20


<210> 13599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGGAT

<400> 13599
gtgtatacat agctaaaaag                                                   20


<210> 13600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 13600
aaattataac taaaaagaaa                                                   20


<210> 13601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 13601
gaagattatc agacatagat                                                   20


<210> 13602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAGT

<400> 13602
tttcctaaat gtattggcat                                                   20


<210> 13603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 13603
ctcgtctaat ttgacgtggt                                                   20


<210> 13604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAAT

<400> 13604
taattgatta cttattcctg                                                   20


<210> 13605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: ATGGGT

<400> 13605
cccagtgtca tagtccactg                                                   20


<210> 13606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TGGAGT

<400> 13606
tgctgataat gtgctttctg                                                   20


<210> 13607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGAGT

<400> 13607
aacatgaaga gccagaaaat                                                   20


<210> 13608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TAGAAT

<400> 13608
gtttgatagg ctgagggagc                                                   20


<210> 13609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: GAGAGT

<400> 13609
taagacaagg gagctgaaca                                                   20


<210> 13610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AGGGAT

<400> 13610
aaaattcttg gacctcacac                                                   20


<210> 13611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: TTGGGT

<400> 13611
acctcaaaac acaggagata                                                   20


<210> 13612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: AAGGGT

<400> 13612
atattgggta gactctgcag                                                   20


<210> 13613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGAAT

<400> 13613
gtcttatctt agcagtgggg                                                   20


<210> 13614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNGRRT; 
      PAM sequence: CTGGAT

<400> 13614
taactttaac taacgttgct                                                   20


<210> 13615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTAGTTT

<400> 13615
taaccgacat taccttagct                                                   20


<210> 13616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGATGTTT

<400> 13616
tggctgtcct gtgcatggtg                                                   20


<210> 13617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGAGTTT

<400> 13617
gacatttatt tctctaaggc                                                   20


<210> 13618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGCTT

<400> 13618
agttaaaagt gtttttcctc                                                   20


<210> 13619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGTTT

<400> 13619
tttttgaagg actaagttaa                                                   20


<210> 13620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGATGTTT

<400> 13620
tttcacatgg taagttgagt                                                   20


<210> 13621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGTGCTT

<400> 13621
cttacattct tatacagtgc                                                   20


<210> 13622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGTTT

<400> 13622
ttcagcctca atagttttct                                                   20


<210> 13623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGTTT

<400> 13623
aatctgtgtg cttcagcctc                                                   20


<210> 13624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGTGCTT

<400> 13624
ctctttccct atcttaatct                                                   20


<210> 13625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAAGCTT

<400> 13625
tattactgtc tacaagttct                                                   20


<210> 13626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAAGATT

<400> 13626
ataaattcta aaatcctcag                                                   20


<210> 13627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCCTGCTT

<400> 13627
tttatgaggt tgtgacattt                                                   20


<210> 13628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTGGATT

<400> 13628
attctcagta cagtagccag                                                   20


<210> 13629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTTGTTT

<400> 13629
ataagacaat gtaataacct                                                   20


<210> 13630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGTTT

<400> 13630
ttgattagta ccaccattca                                                   20


<210> 13631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGATT

<400> 13631
ataaattaca tcttccttct                                                   20


<210> 13632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGATT

<400> 13632
gtataagaga tttgagcatc                                                   20


<210> 13633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGATT

<400> 13633
aaacactatg ccatttgtat                                                   20


<210> 13634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGATT

<400> 13634
catatccatg gtttctgatc                                                   20


<210> 13635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATGGTTT

<400> 13635
tgcattcagt cctccatatc                                                   20


<210> 13636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCAAGATT

<400> 13636
agttcccgag gctgaggagt                                                   20


<210> 13637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGATT

<400> 13637
actcaggagt cagagataat                                                   20


<210> 13638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACATGCTT

<400> 13638
ataattcact ttagcatgtt                                                   20


<210> 13639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGTTT

<400> 13639
aacgtttcat ttggaacata                                                   20


<210> 13640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAACGTTT

<400> 13640
tctacagcaa atgtcttcta                                                   20


<210> 13641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCGTGTTT

<400> 13641
ctccctgttg actatcctaa                                                   20


<210> 13642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGAGATT

<400> 13642
tcttatcaaa aatttaaagg                                                   20


<210> 13643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GACAGTTT

<400> 13643
aaagagaggg acactggtga                                                   20


<210> 13644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCTGTTT

<400> 13644
gatcaaacac aaatgcatgc                                                   20


<210> 13645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGCTT

<400> 13645
tacattgaca atatgttaaa                                                   20


<210> 13646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGATT

<400> 13646
ggcccttcat ctgaggagcc                                                   20


<210> 13647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCTGCTT

<400> 13647
acataatctg gatttgcatg                                                   20


<210> 13648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTGGATT

<400> 13648
ctaaatatgt gagaacataa                                                   20


<210> 13649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTAGTTT

<400> 13649
tgtaatattt gctggcatga                                                   20


<210> 13650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGAGCTT

<400> 13650
ataagtatac agaaaatgtt                                                   20


<210> 13651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGCTT

<400> 13651
taataactgc atcattgcac                                                   20


<210> 13652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGATT

<400> 13652
gtctgcgaaa aggtaatttg                                                   20


<210> 13653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTAGCTT

<400> 13653
aatagagctc acatgctaca                                                   20


<210> 13654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGGGATT

<400> 13654
ttacatacta gctagagcag                                                   20


<210> 13655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGATT

<400> 13655
actgtaatcc atttcaacat                                                   20


<210> 13656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTAGCTT

<400> 13656
aatatgcaca tttataaagg                                                   20


<210> 13657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGAGATT

<400> 13657
atttcaaaat ttagctactt                                                   20


<210> 13658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGTTT

<400> 13658
agtataacta tagtgcccaa                                                   20


<210> 13659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAAGCTT

<400> 13659
ggttgtaatg atagaatgag                                                   20


<210> 13660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGAGTTT

<400> 13660
cccagttaag ccatgaccct                                                   20


<210> 13661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGCTT

<400> 13661
tcattgttct aatttctttg                                                   20


<210> 13662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGATT

<400> 13662
ctattactac taatataaat                                                   20


<210> 13663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTGGATT

<400> 13663
cctgtatgac acagaagtag                                                   20


<210> 13664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGCTT

<400> 13664
gtgtagcata cataatggct                                                   20


<210> 13665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAGGTTT

<400> 13665
taatttcttg aaatccacat                                                   20


<210> 13666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GACAGCTT

<400> 13666
tttttccttt tcattgaaag                                                   20


<210> 13667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATAGCTT

<400> 13667
ctaaataagt tgcaacaact                                                   20


<210> 13668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGTTT

<400> 13668
aaattatgtt tacacgtatt                                                   20


<210> 13669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGTTT

<400> 13669
aaaagttata caaaataaaa                                                   20


<210> 13670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGAGTTT

<400> 13670
tctatgaatg ctcaaaatgt                                                   20


<210> 13671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 13671
catagatcta tgaatgctca                                                   20


<210> 13672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAGGATT

<400> 13672
aatatcataa agctgtttac                                                   20


<210> 13673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCTGTTT

<400> 13673
aatagccatg aatatcataa                                                   20


<210> 13674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGCTT

<400> 13674
tcttgaggaa aacaatcaag                                                   20


<210> 13675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGTTT

<400> 13675
accaattttt taaaaatatc                                                   20


<210> 13676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGTTT

<400> 13676
aggatggcca gggaattggc                                                   20


<210> 13677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATAGCTT

<400> 13677
gcatgatttt atagagtttt                                                   20


<210> 13678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGAGTTT

<400> 13678
aaatacttag catgatttta                                                   20


<210> 13679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCATGATT

<400> 13679
atcacaaccc aaaatactta                                                   20


<210> 13680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCTGATT

<400> 13680
acttgtgagc tgtttttaaa                                                   20


<210> 13681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCTGTTT

<400> 13681
aaagatttgg gtgacttgtg                                                   20


<210> 13682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGATT

<400> 13682
ttgatagtta cctagtttgc                                                   20


<210> 13683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTAGTTT

<400> 13683
ttttagcttt ttgatagtta                                                   20


<210> 13684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGCTT

<400> 13684
tgaaaattag agaacctaat                                                   20


<210> 13685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAGGTTT

<400> 13685
catgagccac catgccccaa                                                   20


<210> 13686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTGGCTT

<400> 13686
gcccaggcta gtctcaaact                                                   20


<210> 13687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAGGTTT

<400> 13687
ttagaataaa atggaagcaa                                                   20


<210> 13688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATGGTTT

<400> 13688
tgtagattac tgtttgtact                                                   20


<210> 13689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACTGTTT

<400> 13689
acctctcttt ccatgtagat                                                   20


<210> 13690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGATT

<400> 13690
aaattagacc tctctttcca                                                   20


<210> 13691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGCTT

<400> 13691
gaagaaagag cttattaagt                                                   20


<210> 13692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGCTT

<400> 13692
taaaaataat atttggaaga                                                   20


<210> 13693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGTTT

<400> 13693
taagttttat atatatttac                                                   20


<210> 13694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTACGTTT

<400> 13694
tggttaagtt ttatatatat                                                   20


<210> 13695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAAGTTT

<400> 13695
ttttttttaa aataacatgg                                                   20


<210> 13696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTATGTTT

<400> 13696
tctttttcct atttcatgaa                                                   20


<210> 13697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTGGTTT

<400> 13697
taaaataaaa aatatgggca                                                   20


<210> 13698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTTGTTT

<400> 13698
ctattaatgt ttttacattg                                                   20


<210> 13699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGTTT

<400> 13699
gttcgtgtgt aattttctat                                                   20


<210> 13700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGTTT

<400> 13700
ttacataatg tagtaagaca                                                   20


<210> 13701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCAGATT

<400> 13701
atacaaaata tattacattt                                                   20


<210> 13702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAGGTTT

<400> 13702
acctaccaag cctgttggaa                                                   20


<210> 13703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGTGTTT

<400> 13703
ttaatatgaa agacaccatg                                                   20


<210> 13704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGATT

<400> 13704
tataaaactc aatctagggc                                                   20


<210> 13705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGTTT

<400> 13705
agaatgagat cagaagtcta                                                   20


<210> 13706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAAGATT

<400> 13706
tttaaacgta cctatagaaa                                                   20


<210> 13707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAGGATT

<400> 13707
ttctggcaat ttaaaaagaa                                                   20


<210> 13708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 13708
ataaattaca tttatataat                                                   20


<210> 13709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGCTT

<400> 13709
atataaaaca actttcacta                                                   20


<210> 13710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGAGGTTT

<400> 13710
ttacttagaa gatttttgtg                                                   20


<210> 13711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAAGATT

<400> 13711
ggtagaatgt agttttactt                                                   20


<210> 13712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGTTT

<400> 13712
attgagctac acaggtagaa                                                   20


<210> 13713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGAGTTT

<400> 13713
taaccataat gctttttttc                                                   20


<210> 13714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGCTT

<400> 13714
aatttgaaaa gaaataacca                                                   20


<210> 13715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTAGTTT

<400> 13715
ttttgcatta gctgtagaca                                                   20


<210> 13716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGGGCTT

<400> 13716
gcctcaatca acacagtacc                                                   20


<210> 13717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGGGATT

<400> 13717
tgaataaaaa agcattgaaa                                                   20


<210> 13718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGTTT

<400> 13718
atgacagact ttacacagat                                                   20


<210> 13719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCAAGCTT

<400> 13719
tgtatacaat cccgtgtttg                                                   20


<210> 13720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCGTGTTT

<400> 13720
tgcatcactt gtatacaatc                                                   20


<210> 13721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTTGTTT

<400> 13721
atccttcctg atatgcagtt                                                   20


<210> 13722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGTTT

<400> 13722
tttcctgctt tcttatgcag                                                   20


<210> 13723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCTGCTT

<400> 13723
taaactcttt tgtcaaattt                                                   20


<210> 13724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGTTT

<400> 13724
taagacttac ctttagagta                                                   20


<210> 13725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 13725
tgtaggctat tcatttctac                                                   20


<210> 13726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGGGATT

<400> 13726
atatgtgcct ataaaatgcc                                                   20


<210> 13727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGTGCTT

<400> 13727
agaggttatt ctatattttg                                                   20


<210> 13728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGGAGCTT

<400> 13728
ttagttaaaa tgcattatta                                                   20


<210> 13729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGTTT

<400> 13729
aagtaatgga cattagttat                                                   20


<210> 13730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGCTT

<400> 13730
tttgccttgg ctttgcaatg                                                   20


<210> 13731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTGGCTT

<400> 13731
aaatcaacaa aagtatttgc                                                   20


<210> 13732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGTTT

<400> 13732
tttcacagga ttgtaattag                                                   20


<210> 13733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAGGATT

<400> 13733
atctgccttg tcatcttttc                                                   20


<210> 13734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGTTT

<400> 13734
atacaaaagt gattcagttt                                                   20


<210> 13735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGTTT

<400> 13735
attatagcat acaaaagtga                                                   20


<210> 13736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGATT

<400> 13736
ttattgatta tagcatacaa                                                   20


<210> 13737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGATT

<400> 13737
taagagaact ctgtaggaat                                                   20


<210> 13738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGATGATT

<400> 13738
gcagatggtt atttttgcac                                                   20


<210> 13739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCTGATT

<400> 13739
gaaggcagtg cagtcactaa                                                   20


<210> 13740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGATT

<400> 13740
atattgttta cagcctgtga                                                   20


<210> 13741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGTTT

<400> 13741
atagagcttc atttttgata                                                   20


<210> 13742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGAGCTT

<400> 13742
acagcaagga aagcaaaaaa                                                   20


<210> 13743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATGGCTT

<400> 13743
gatttactca ataaaaaaga                                                   20


<210> 13744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGATGATT

<400> 13744
ataaaagatg gagacagaga                                                   20


<210> 13745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACCGCTT

<400> 13745
ttcagcgtgc ttatagacgt                                                   20


<210> 13746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCGTGCTT

<400> 13746
gtgtctgcta ctgtcattca                                                   20


<210> 13747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATGGATT

<400> 13747
gttttgggtg agagtgggga                                                   20


<210> 13748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCGTGTTT

<400> 13748
atcttatttg cttttacaaa                                                   20


<210> 13749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGCTT

<400> 13749
atccattgtc ttgacatctt                                                   20


<210> 13750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCTGATT

<400> 13750
tttatagagt tctctaaact                                                   20


<210> 13751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCCAGTTT

<400> 13751
gaagtttgat cccgatgcga                                                   20


<210> 13752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAAGTTT

<400> 13752
gatgttctat gaggtttggg                                                   20


<210> 13753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAGGTTT

<400> 13753
gatgactttg agatgttcta                                                   20


<210> 13754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATGGATT

<400> 13754
ttacaacctc tgctggctgg                                                   20


<210> 13755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTATGATT

<400> 13755
ttttgagacc tttggcaaca                                                   20


<210> 13756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGTTGTTT

<400> 13756
tttgatgatg tcccttcctg                                                   20


<210> 13757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGCTT

<400> 13757
aaggggatcc gcacgctgct                                                   20


<210> 13758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCAGGATT

<400> 13758
gttccgagtg atccgtcttg                                                   20


<210> 13759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGATT

<400> 13759
tacaggtatg tttctagctg                                                   20


<210> 13760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCTGATT

<400> 13760
ccacatacag gtatgtttct                                                   20


<210> 13761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTATGTTT

<400> 13761
ttattttcct ccacatacag                                                   20


<210> 13762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACTGTTT

<400> 13762
agaaatgagt tgacagataa                                                   20


<210> 13763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGGAGCTT

<400> 13763
aatggcgtga acccgggagg                                                   20


<210> 13764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGCTT

<400> 13764
ttctttttag catttaacgg                                                   20


<210> 13765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGTGATT

<400> 13765
atagttattg ttgacatttc                                                   20


<210> 13766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGCTT

<400> 13766
acatttgttt gtgtgtgtac                                                   20


<210> 13767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 13767
agcttatata acatgaatac                                                   20


<210> 13768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGCTT

<400> 13768
ataaataaat aggttacaaa                                                   20


<210> 13769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGCTT

<400> 13769
ccaagatcac accaccgcac                                                   20


<210> 13770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGAGATT

<400> 13770
aatcatttga tcccgggatg                                                   20


<210> 13771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAAGTTT

<400> 13771
gggcgaaatc acttgaagtc                                                   20


<210> 13772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAGGCTT

<400> 13772
cattagaaat gttaattagt                                                   20


<210> 13773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGTTT

<400> 13773
tgcaaataaa ttacaatagt                                                   20


<210> 13774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGATT

<400> 13774
taacaaaaca caaggaaaat                                                   20


<210> 13775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 13775
tgaaagacaa aaaataggtg                                                   20


<210> 13776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGATT

<400> 13776
tcaaaatcta aagttaaaaa                                                   20


<210> 13777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGGGTTT

<400> 13777
tgttcaaata taaaagctca                                                   20


<210> 13778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTGGCTT

<400> 13778
agaaaattag ggtgacaaga                                                   20


<210> 13779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGATT

<400> 13779
gacaaaaaca atataagtct                                                   20


<210> 13780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGCTT

<400> 13780
aaggattgtc atgtacttag                                                   20


<210> 13781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGATT

<400> 13781
aaagaaagct aaaataattg                                                   20


<210> 13782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCTGATT

<400> 13782
tacatgaaaa aaattagaaa                                                   20


<210> 13783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCCTGTTT

<400> 13783
aaagagtgtg cctgtatcat                                                   20


<210> 13784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGATT

<400> 13784
tgagaatttc acactaacaa                                                   20


<210> 13785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAAGTTT

<400> 13785
gagagattat agagattact                                                   20


<210> 13786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGAGATT

<400> 13786
cttttaagag agagagatta                                                   20


<210> 13787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGAGATT

<400> 13787
aattataaac ttttaagaga                                                   20


<210> 13788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAGGATT

<400> 13788
cacatatctt gcaaagtatt                                                   20


<210> 13789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGTTT

<400> 13789
ccatggttgt ttttctatct                                                   20


<210> 13790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTTGTTT

<400> 13790
tcctatacat tcattgccat                                                   20


<210> 13791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACATGATT

<400> 13791
tcatgtctgt gaataacagc                                                   20


<210> 13792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACAGCTT

<400> 13792
gaaatgccag ttttattttt                                                   20


<210> 13793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCCAGTTT

<400> 13793
aagttaagat ctctagaaat                                                   20


<210> 13794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGATT

<400> 13794
tagcacatgt gagacttgtc                                                   20


<210> 13795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTGGTTT

<400> 13795
atgttgaatc tgaaataact                                                   20


<210> 13796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCATGTTT

<400> 13796
tacctttgca aaactagtta                                                   20


<210> 13797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGTTT

<400> 13797
ggaaattata cttgttgata                                                   20


<210> 13798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGTTT

<400> 13798
tctctcatac tacagtgttt                                                   20


<210> 13799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGTGTTT

<400> 13799
aatatctgtc tctcatacta                                                   20


<210> 13800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGATT

<400> 13800
gtaggtaaga atatttattt                                                   20


<210> 13801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGATT

<400> 13801
gaatattttt gattttgtgg                                                   20


<210> 13802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGATT

<400> 13802
ttcactgtag gatggaatat                                                   20


<210> 13803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGTTT

<400> 13803
gaagttttat attggataaa                                                   20


<210> 13804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGTTT

<400> 13804
ggtcaaagtc aacatatgac                                                   20


<210> 13805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGTTT

<400> 13805
taatttctgg ataatacttg                                                   20


<210> 13806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGATT

<400> 13806
aaatatatat atctttagca                                                   20


<210> 13807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGTTT

<400> 13807
tttaactaca tttatttttt                                                   20


<210> 13808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 13808
tggttttaac tacatttatt                                                   20


<210> 13809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTGGTTT

<400> 13809
agaaagatgt agacaatgat                                                   20


<210> 13810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGATT

<400> 13810
aatctataga aagatgtaga                                                   20


<210> 13811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCATGTTT

<400> 13811
atttaactgt gtttggagac                                                   20


<210> 13812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGTTT

<400> 13812
atttatatat gcacatttaa                                                   20


<210> 13813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACTGATT

<400> 13813
aagtacatag tttaaaacaa                                                   20


<210> 13814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATAGTTT

<400> 13814
agataaaaaa gataaaagta                                                   20


<210> 13815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGATT

<400> 13815
aattgtgaat gggagttcac                                                   20


<210> 13816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTGGATT

<400> 13816
gtccttcaca tcccttgtaa                                                   20


<210> 13817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTGGTTT

<400> 13817
cctcttttat ttcgctgagc                                                   20


<210> 13818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 13818
tgagcatgga atattcttcc                                                   20


<210> 13819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTAGCTT

<400> 13819
attttgtgaa gaaagtcagt                                                   20


<210> 13820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTAGTTT

<400> 13820
tggttccata tgaactttaa                                                   20


<210> 13821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAGGATT

<400> 13821
tccagctttg ttctttttgc                                                   20


<210> 13822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGCTT

<400> 13822
gacgcctcca gctttgttct                                                   20


<210> 13823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGCTT

<400> 13823
aagtcaggta gtgtgacgcc                                                   20


<210> 13824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGTTT

<400> 13824
tggttactgt agccttgtag                                                   20


<210> 13825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCTGTTT

<400> 13825
ctgttttggt accagtacca                                                   20


<210> 13826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCTGTTT

<400> 13826
tctgttctgt tggtgtatgt                                                   20


<210> 13827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAGGTTT

<400> 13827
ttccccgttg cttgtttttg                                                   20


<210> 13828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTTGTTT

<400> 13828
tagggaagcc tttccccgtt                                                   20


<210> 13829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGTTGCTT

<400> 13829
taaataggga agcctttccc                                                   20


<210> 13830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCCAGTTT

<400> 13830
caactttcta catatggcta                                                   20


<210> 13831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGTTT

<400> 13831
tacaaggtgt aaggaaggga                                                   20


<210> 13832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATGGTTT

<400> 13832
agagtttctt ctagggtttt                                                   20


<210> 13833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGGGTTT

<400> 13833
atattgccta gagtttcttc                                                   20


<210> 13834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGAGTTT

<400> 13834
atgtcctgaa tgatattgcc                                                   20


<210> 13835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGTGTTT

<400> 13835
gcttttgttg ccattgcttt                                                   20


<210> 13836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGCTT

<400> 13836
tctgttttgg cttttgttgc                                                   20


<210> 13837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGCTT

<400> 13837
attagatccc atttgtctgt                                                   20


<210> 13838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCTGTTT

<400> 13838
agtttaatta gatcccattt                                                   20


<210> 13839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGTTT

<400> 13839
cttttgcttt gcagaagctc                                                   20


<210> 13840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGCTT

<400> 13840
ttcactctga tgatagtttc                                                   20


<210> 13841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATAGTTT

<400> 13841
ggttgcctgt tcactctgat                                                   20


<210> 13842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGATT

<400> 13842
gtaaatttgt ttaagttctt                                                   20


<210> 13843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 13843
tgtttgtttt tttcttgtaa                                                   20


<210> 13844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGTTT

<400> 13844
gcccactttt tgatggagtt                                                   20


<210> 13845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTTGTTT

<400> 13845
ctttgcccac tttttgatgg                                                   20


<210> 13846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGTTT

<400> 13846
tatctcattg tggttttgat                                                   20


<210> 13847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGATT

<400> 13847
gaggtggtat ctcattgtgg                                                   20


<210> 13848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGTTT

<400> 13848
ggcatgaggt ggtatctcat                                                   20


<210> 13849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGTGATT

<400> 13849
tctgttgttt cctgactttt                                                   20


<210> 13850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGTTT

<400> 13850
tccacatcct ctccaacatc                                                   20


<210> 13851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGATT

<400> 13851
ggtcaaatgg tatttctagt                                                   20


<210> 13852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTAGTTT

<400> 13852
ttgctgggtc aaatggtatt                                                   20


<210> 13853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGAGATT

<400> 13853
ccttgagtat atacccagta                                                   20


<210> 13854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCATGATT

<400> 13854
atgcatgtgt ctttatagta                                                   20


<210> 13855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGCTT

<400> 13855
ttttgctgag aatgatggtt                                                   20


<210> 13856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATGGTTT

<400> 13856
tgtgatattt tgctgagaat                                                   20


<210> 13857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGTTT

<400> 13857
atgagtgaga acatgcagag                                                   20


<210> 13858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGAGTTT

<400> 13858
cacttatgag tgagaacatg                                                   20


<210> 13859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTGGTTT

<400> 13859
cataggtata catgtaccat                                                   20


<210> 13860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCAGGTTT

<400> 13860
agggtacatg tgcaaaacat                                                   20


<210> 13861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGTTT

<400> 13861
atagaaatgt atattatcat                                                   20


<210> 13862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGTTT

<400> 13862
tagaattaaa aaggtagtca                                                   20


<210> 13863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGTTT

<400> 13863
gataatgttg acatccaata                                                   20


<210> 13864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGTTT

<400> 13864
tgtaatcaat tggaaagtcc                                                   20


<210> 13865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAGGCTT

<400> 13865
ctagcccccc tttgtaagat                                                   20


<210> 13866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTAAGATT

<400> 13866
gaagcttcta gccccccttt                                                   20


<210> 13867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGCTT

<400> 13867
cagagaacaa agggagcaac                                                   20


<210> 13868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATGGATT

<400> 13868
tgaaaataaa ttcttaatta                                                   20


<210> 13869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGAAGCTT

<400> 13869
taagaaaatt caatataatg                                                   20


<210> 13870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGTGTTT

<400> 13870
agggaagtct ggttaccatt                                                   20


<210> 13871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGTTT

<400> 13871
attaatgaac agtaaaggat                                                   20


<210> 13872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGCTT

<400> 13872
agttttctcc tcagtttttc                                                   20


<210> 13873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCAGTTT

<400> 13873
ttcaaagttg gagttttctc                                                   20


<210> 13874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGAGTTT

<400> 13874
tttgattttc tcttcaaagt                                                   20


<210> 13875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGATT

<400> 13875
ggggaaaaca aaatctatta                                                   20


<210> 13876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTAGTTT

<400> 13876
gaattaattc ataatctcct                                                   20


<210> 13877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCAAGTTT

<400> 13877
taggaaaaca aaacacccac                                                   20


<210> 13878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTAGGTTT

<400> 13878
acttacagaa ttccttccac                                                   20


<210> 13879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGATT

<400> 13879
actatgtaat acagcctcaa                                                   20


<210> 13880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTGGTTT

<400> 13880
gactactctt ataatgatga                                                   20


<210> 13881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGAAGTTT

<400> 13881
cattaactct catcttatca                                                   20


<210> 13882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGAAGATT

<400> 13882
atgagttcaa gttataaaaa                                                   20


<210> 13883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTAGTTT

<400> 13883
ctctaatgat ttcatgtgaa                                                   20


<210> 13884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGATT

<400> 13884
ataagtactt ttttcacctc                                                   20


<210> 13885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTAGTTT

<400> 13885
ctaataacca accctatttt                                                   20


<210> 13886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAAGCTT

<400> 13886
tttaacttca ataatttgat                                                   20


<210> 13887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACTGCTT

<400> 13887
cacaatgcaa tgttgccact                                                   20


<210> 13888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGATT

<400> 13888
cagttatgat tgaaatgcct                                                   20


<210> 13889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCCTGTTT

<400> 13889
agcacagtta tgattgaaat                                                   20


<210> 13890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGATT

<400> 13890
gtaacaggat accagcacag                                                   20


<210> 13891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGTTT

<400> 13891
gcccctagaa aggatggata                                                   20


<210> 13892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTATGTTT

<400> 13892
taatctaccg tccccttttc                                                   20


<210> 13893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCAAGATT

<400> 13893
caaaggacac aaaacagcca                                                   20


<210> 13894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGCTT

<400> 13894
tccctaattc tttgtgttcc                                                   20


<210> 13895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGTTT

<400> 13895
ggatttcttt tatccctttt                                                   20


<210> 13896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCGGATT

<400> 13896
atttctttag ggtcagtaac                                                   20


<210> 13897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 13897
ttcatgtatc atcttcctga                                                   20


<210> 13898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCTGATT

<400> 13898
attgtgttca tgtatcatct                                                   20


<210> 13899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGTTT

<400> 13899
tgactttttg tgtgtgtgtg                                                   20


<210> 13900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGAGTTT

<400> 13900
attattgtat tcttcaattc                                                   20


<210> 13901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGGAGTTT

<400> 13901
gtctgctatt gaatcctcta                                                   20


<210> 13902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGTTT

<400> 13902
cttggtttgt tgattctttc                                                   20


<210> 13903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGATT

<400> 13903
gggttgtttt tttcttggtt                                                   20


<210> 13904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTGGTTT

<400> 13904
tttgatgggg ttgttttttt                                                   20


<210> 13905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTTGTTT

<400> 13905
ctttacccag tttttgatgg                                                   20


<210> 13906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCCAGTTT

<400> 13906
gtgtctgttc atatccttta                                                   20


<210> 13907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGTTT

<400> 13907
gtgatgatga gcattttttc                                                   20


<210> 13908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGATT

<400> 13908
gagatggtat ctcattgcgg                                                   20


<210> 13909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCGGTTT

<400> 13909
ggtatgagat ggtatctcat                                                   20


<210> 13910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGTTT

<400> 13910
tccacatcct ctccagcacc                                                   20


<210> 13911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTAGTTT

<400> 13911
cggacttcca cagtggttga                                                   20


<210> 13912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCATGATT

<400> 13912
gtgcatgcgt ctttatagca                                                   20


<210> 13913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGCTT

<400> 13913
cagtctatca ttgttggaca                                                   20


<210> 13914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGCTT

<400> 13914
gtttgctgag aatgatggtt                                                   20


<210> 13915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATGGTTT

<400> 13915
tgcgatagtt tgctgagaat                                                   20


<210> 13916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATAGTTT

<400> 13916
tgtttggttt ttttccttgc                                                   20


<210> 13917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGTTT

<400> 13917
atgagtgaga aagtgcagtg                                                   20


<210> 13918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGTGTTT

<400> 13918
cacctatgag tgagaaagtg                                                   20


<210> 13919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAAGTTT

<400> 13919
tttttatttt ttattatact                                                   20


<210> 13920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGGGTTT

<400> 13920
ttttttggtg tccatctttt                                                   20


<210> 13921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGATT

<400> 13921
tacacccctt tctgtcttct                                                   20


<210> 13922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGAGTTT

<400> 13922
tttgtcctat ttgggattct                                                   20


<210> 13923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGGGATT

<400> 13923
cttctttaga tttgtcctat                                                   20


<210> 13924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGATT

<400> 13924
ccatgcccag ccgagacttc                                                   20


<210> 13925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGATT

<400> 13925
ccgctcagcc cctcaaagtg                                                   20


<210> 13926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGTTT

<400> 13926
tttgtaattt ttggtagaga                                                   20


<210> 13927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCTGATT

<400> 13927
aggcacccac caccacaccc                                                   20


<210> 13928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGATT

<400> 13928
tgcctcagcc tcccgagtag                                                   20


<210> 13929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGAGTTT

<400> 13929
tctttctttt ttttccgaga                                                   20


<210> 13930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCTGCTT

<400> 13930
tgacaattca gtttttttct                                                   20


<210> 13931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGTTT

<400> 13931
agctcttttg gacatgacaa                                                   20


<210> 13932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGTTT

<400> 13932
tttcacttta tttgctcttt                                                   20


<210> 13933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCAGTTT

<400> 13933
caggtatatt attcttggtc                                                   20


<210> 13934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GACAGTTT

<400> 13934
atccttcctt aattttaaag                                                   20


<210> 13935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAAGTTT

<400> 13935
ctcagcattt gcttgtatga                                                   20


<210> 13936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGCTT

<400> 13936
tggtgatgaa ctccctcagc                                                   20


<210> 13937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTCGTTT

<400> 13937
tgtgttgctc tttaccatgc                                                   20


<210> 13938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCATGCTT

<400> 13938
tgctcttgtg ttgctcttta                                                   20


<210> 13939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGCTT

<400> 13939
tttaccttta ctagtgagat                                                   20


<210> 13940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGAGATT

<400> 13940
ccatgtattt acctttacta                                                   20


<210> 13941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGATT

<400> 13941
aacttttata ttagaattat                                                   20


<210> 13942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGTTT

<400> 13942
acaatttaca tctttttata                                                   20


<210> 13943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGTGGATT

<400> 13943
tttttatttc tgtattttta                                                   20


<210> 13944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTATGATT

<400> 13944
tgatatttta ttgtgatatg                                                   20


<210> 13945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGATT

<400> 13945
tctctcttaa ctgtcttctt                                                   20


<210> 13946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGTTT

<400> 13946
attgcctttt tgttaaattt                                                   20


<210> 13947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGAAGTTT

<400> 13947
cattgtaggt cttttgattg                                                   20


<210> 13948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGATT

<400> 13948
ctatgcagcc attgtaggtc                                                   20


<210> 13949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGTTT

<400> 13949
ggagacagca tataactgga                                                   20


<210> 13950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTATGTTT

<400> 13950
tttatcaatt aactttcaaa                                                   20


<210> 13951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCTGATT

<400> 13951
acatctgtag attcagccaa                                                   20


<210> 13952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGATT

<400> 13952
gtgtctgtgg gttttacatc                                                   20


<210> 13953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGGGTTT

<400> 13953
acagggtgtc ctctgtgtct                                                   20


<210> 13954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GACAGTTT

<400> 13954
tgacctactt tgtctcttgt                                                   20


<210> 13955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATGGATT

<400> 13955
acgtatttac atgctttgat                                                   20


<210> 13956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACATGCTT

<400> 13956
aatgattgct ttacgtattt                                                   20


<210> 13957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATTGCTT

<400> 13957
atcccttcag atctgtcaat                                                   20


<210> 13958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGATT

<400> 13958
gtttatccct tcagatctgt                                                   20


<210> 13959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCATGTTT

<400> 13959
cctactgtta tggtgttgct                                                   20


<210> 13960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGATT

<400> 13960
gttcaaatcc acagtttgtt                                                   20


<210> 13961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGTTT

<400> 13961
tagcgttgtt caaatccaca                                                   20


<210> 13962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACAGTTT

<400> 13962
tctatagcgt tgttcaaatc                                                   20


<210> 13963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGTGTTT

<400> 13963
gctgttgggt agcatattct                                                   20


<210> 13964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTATGATT

<400> 13964
gtggtcataa aagatatctg                                                   20


<210> 13965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGTTT

<400> 13965
ttttccttct attactgact                                                   20


<210> 13966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGTTT

<400> 13966
ttccacatat ttgtgaattt                                                   20


<210> 13967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGTTT

<400> 13967
ccattgcttt ttcaagagag                                                   20


<210> 13968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGCTT

<400> 13968
ttgatttttt ttctttgacc                                                   20


<210> 13969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGATT

<400> 13969
aagatacttt taaattttcc                                                   20


<210> 13970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGTTT

<400> 13970
gaaattgtgc tttcattttt                                                   20


<210> 13971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 13971
tttggaaatt gtgctttcat                                                   20


<210> 13972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGCTT

<400> 13972
catctcataa attttggaaa                                                   20


<210> 13973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACTGCTT

<400> 13973
tcaataagat ttgcttttat                                                   20


<210> 13974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGCTT

<400> 13974
tagacatgta tctcaataag                                                   20


<210> 13975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGATT

<400> 13975
taatgtagac atgtatctca                                                   20


<210> 13976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGTTT

<400> 13976
ttcctagaca tgtaaatcta                                                   20


<210> 13977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTAGTTT

<400> 13977
ttccttttgc tgatgttggg                                                   20


<210> 13978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGGGCTT

<400> 13978
tttccttcct tttgctgatg                                                   20


<210> 13979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGCTT

<400> 13979
ttagttttgt tgactttttc                                                   20


<210> 13980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTAGTTT

<400> 13980
atctttcgaa aaaaccaatt                                                   20


<210> 13981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAGGATT

<400> 13981
tttttcttag ttatgcttgc                                                   20


<210> 13982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGCTT

<400> 13982
tcctctatct tttttcttag                                                   20


<210> 13983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTGGTTT

<400> 13983
gtaaattctc ctctttcatt                                                   20


<210> 13984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGATT

<400> 13984
tattcagtta ttctatttcc                                                   20


<210> 13985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 13985
attaatgttg tttcttcttt                                                   20


<210> 13986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGTTT

<400> 13986
gagagtttga gaagaattaa                                                   20


<210> 13987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGAGTTT

<400> 13987
tttcctcttc aaagttttaa                                                   20


<210> 13988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAAGTTT

<400> 13988
tcgaagtgtt ctttcctctt                                                   20


<210> 13989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTGGCTT

<400> 13989
cttttcttac agtgtctttg                                                   20


<210> 13990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGTTT

<400> 13990
gaactgatcc atgtgtatgt                                                   20


<210> 13991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGTTT

<400> 13991
atgagttttt ctactggatt                                                   20


<210> 13992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTGGATT

<400> 13992
tggtgtgcat gagtttttct                                                   20


<210> 13993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGAGTTT

<400> 13993
ttttctgtcc tctggtgtgc                                                   20


<210> 13994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGTTT

<400> 13994
ccttgggaag tagctgcaaa                                                   20


<210> 13995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGTTT

<400> 13995
gttgggttct atatgtgtgc                                                   20


<210> 13996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGATT

<400> 13996
gaaaaccaag gcaattatga                                                   20


<210> 13997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATGGCTT

<400> 13997
tgtacttgag agaaaactcc                                                   20


<210> 13998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATCGTTT

<400> 13998
tcaggcagtt caaaaccccc                                                   20


<210> 13999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGCTT

<400> 13999
gatggtctga tcccaggaat                                                   20


<210> 14000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATGGTTT

<400> 14000
ggctggaaaa cgtgtagcct                                                   20


<210> 14001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGATT

<400> 14001
ggtttattct tcatttgcta                                                   20


<210> 14002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAGGTTT

<400> 14002
ttcctcttgt ttaggctgaa                                                   20


<210> 14003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGTTT

<400> 14003
ggcgtgggga atgttattcc                                                   20


<210> 14004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGGGATT

<400> 14004
aaaaaagaaa gattgtagag                                                   20


<210> 14005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAAGATT

<400> 14005
aaaaaaaaaa aaaaaaaaaa                                                   20


<210> 14006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCGAGATT

<400> 14006
gaggcggagc ttgcagtgag                                                   20


<210> 14007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGGAGCTT

<400> 14007
aatggcatga acccgggagg                                                   20


<210> 14008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAAGATT

<400> 14008
accttccaca tcttttaaaa                                                   20


<210> 14009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTGGATT

<400> 14009
tataaatatc tgttagatct                                                   20


<210> 14010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGATT

<400> 14010
tctatcctgg agagtgtttc                                                   20


<210> 14011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGTGTTT

<400> 14011
aacatgtgat ctatcctgga                                                   20


<210> 14012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTTGTTT

<400> 14012
atcttcttaa atttgttaaa                                                   20


<210> 14013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGATT

<400> 14013
atgaacagaa aacatactcg                                                   20


<210> 14014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTAGTTT

<400> 14014
caaggttatt cttattgact                                                   20


<210> 14015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGTTT

<400> 14015
ccattgcctg ttcaggagca                                                   20


<210> 14016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGTTT

<400> 14016
gtcattgatc ccaaaatatt                                                   20


<210> 14017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGTTT

<400> 14017
attccatact atttgttatc                                                   20


<210> 14018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGGGCTT

<400> 14018
attactataa atttttctct                                                   20


<210> 14019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGAGATT

<400> 14019
tgtaatatta ggttgtttat                                                   20


<210> 14020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTTGTTT

<400> 14020
atctctaaga tgtaatatta                                                   20


<210> 14021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAAGTTT

<400> 14021
ttgttatttt cttccttctg                                                   20


<210> 14022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGTTT

<400> 14022
aaacaacttt ttagtatttg                                                   20


<210> 14023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGCTT

<400> 14023
caaaaaaaca actttttagt                                                   20


<210> 14024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTCGATT

<400> 14024
ggttagtcta gttaaaggtt                                                   20


<210> 14025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGTTT

<400> 14025
ttcccttggt tagtctagtt                                                   20


<210> 14026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGTTT

<400> 14026
ctcccttctt tcatttcaga                                                   20


<210> 14027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGATT

<400> 14027
tggttgttca cattaatagt                                                   20


<210> 14028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGTTT

<400> 14028
ggtgtatggt tgttcacatt                                                   20


<210> 14029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGATT

<400> 14029
cttggtaggt tgcatgtttc                                                   20


<210> 14030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCATGTTT

<400> 14030
tgatttagtc ttggtaggtt                                                   20


<210> 14031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGATT

<400> 14031
gtttgttcag atgtaatatt                                                   20


<210> 14032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTGGTTT

<400> 14032
atctattttc tttatccagt                                                   20


<210> 14033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGGGTTT

<400> 14033
cttttctggt agcatactct                                                   20


<210> 14034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCAGTTT

<400> 14034
gttcatcaag aatattggcc                                                   20


<210> 14035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGTTT

<400> 14035
gttttaaatg tgctagggaa                                                   20


<210> 14036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGATGTTT

<400> 14036
tcccaagtaa tcatggtgaa                                                   20


<210> 14037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTATGTTT

<400> 14037
tatcacattt attgatttat                                                   20


<210> 14038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGATT

<400> 14038
ttaatgtagc atatcacatt                                                   20


<210> 14039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGATT

<400> 14039
ctgcatctag taagatgatc                                                   20


<210> 14040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGCTT

<400> 14040
aacatatgct ggattttatc                                                   20


<210> 14041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTGGATT

<400> 14041
agattttatt atgaacatat                                                   20


<210> 14042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGAGATT

<400> 14042
ttccttccat atctgctttg                                                   20


<210> 14043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCTGCTT

<400> 14043
ttaaggtaca ttccttccat                                                   20


<210> 14044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATGGCTT

<400> 14044
ttagccgtgg gcttgtcata                                                   20


<210> 14045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGGGCTT

<400> 14045
gtttttgcat aatgttagcc                                                   20


<210> 14046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGTTT

<400> 14046
agaagaaaag ctcccaactt                                                   20


<210> 14047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGGGATT

<400> 14047
ttcctgccta attgctatgg                                                   20


<210> 14048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGCTT

<400> 14048
caaacagaga taattttatt                                                   20


<210> 14049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGGGTTT

<400> 14049
acagttctca gtagagtgtt                                                   20


<210> 14050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCAGTTT

<400> 14050
caactttact gaatttatgt                                                   20


<210> 14051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGATT

<400> 14051
aaatgctact gatttttcta                                                   20


<210> 14052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACTGATT

<400> 14052
ttgttaatgt atagaaatgc                                                   20


<210> 14053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAGGATT

<400> 14053
ttattttgat gctgttttaa                                                   20


<210> 14054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCTGTTT

<400> 14054
attttattta tttattttga                                                   20


<210> 14055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGTTT

<400> 14055
tcagtttttt taaatcaact                                                   20


<210> 14056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCAGTTT

<400> 14056
tacaatttat ttgtgtcttc                                                   20


<210> 14057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGATT

<400> 14057
gatagggatt gcattgaatc                                                   20


<210> 14058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGGGATT

<400> 14058
aactgacatt agaattttga                                                   20


<210> 14059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAGGATT

<400> 14059
ttttttattt tattcaaatg                                                   20


<210> 14060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATTGCTT

<400> 14060
agctttgttc tttttgctca                                                   20


<210> 14061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCAGATT

<400> 14061
ctctagcttt gttctttttg                                                   20


<210> 14062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTAGCTT

<400> 14062
aaatgacaga gtattgcacc                                                   20


<210> 14063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATAGCTT

<400> 14063
atctgtgttt atgccaatag                                                   20


<210> 14064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGTTT

<400> 14064
ttttccatta gccaatatat                                                   20


<210> 14065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGCTT

<400> 14065
ataaataatt gggtttattt                                                   20


<210> 14066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGGGTTT

<400> 14066
aatcaattga ctataaataa                                                   20


<210> 14067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGTTT

<400> 14067
gaagagatcg tcctttcccc                                                   20


<210> 14068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGTTT

<400> 14068
attcttttgc ataaggaata                                                   20


<210> 14069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGTTT

<400> 14069
atatttaagt cttttacttg                                                   20


<210> 14070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTTGTTT

<400> 14070
ttcttatatt taagtctttt                                                   20


<210> 14071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGTTT

<400> 14071
atgttttctt ctagtagctt                                                   20


<210> 14072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTAGCTT

<400> 14072
tttcttttat gttttcttct                                                   20


<210> 14073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGTTT

<400> 14073
aatgtcatac agcttttctt                                                   20


<210> 14074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACAGCTT

<400> 14074
ccttgcccag ataaatgtca                                                   20


<210> 14075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGCTT

<400> 14075
ctcttattgt cttttgttac                                                   20


<210> 14076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGTTT

<400> 14076
cgtttgctgt aaagaacatt                                                   20


<210> 14077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTCGTTT

<400> 14077
ctctctccac tctgttattg                                                   20


<210> 14078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGCTT

<400> 14078
gatctctctc tccactctgt                                                   20


<210> 14079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATGGTTT

<400> 14079
tattagccct ttatcagatg                                                   20


<210> 14080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGAGCTT

<400> 14080
ttttctaggt gttgagttgc                                                   20


<210> 14081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTTGCTT

<400> 14081
tattgatttt ctaggtgttg                                                   20


<210> 14082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGATT

<400> 14082
tgcccattct acaattggtt                                                   20


<210> 14083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTGGTTT

<400> 14083
gattatttgc ccattctaca                                                   20


<210> 14084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGATT

<400> 14084
cttcttttga gaaatgtctg                                                   20


<210> 14085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGATGATT

<400> 14085
gattttaatt tgcatttttc                                                   20


<210> 14086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGGGATT

<400> 14086
aggtgtgagg taatatttca                                                   20


<210> 14087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 14087
ctgaattata tggtaattgt                                                   20


<210> 14088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAACGATT

<400> 14088
gtgcaggtat acctttgaca                                                   20


<210> 14089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCGGTTT

<400> 14089
tgggttagtg caaaagtaat                                                   20


<210> 14090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGTTT

<400> 14090
aatgacaaaa tttgttcttt                                                   20


<210> 14091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGTTT

<400> 14091
ttttgcttag cataacgtcc                                                   20


<210> 14092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGCTT

<400> 14092
gtctttctgt acctggctaa                                                   20


<210> 14093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCAGGTTT

<400> 14093
agggtacatg tgcacaacgt                                                   20


<210> 14094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCTGTTT

<400> 14094
ctatggcaac cacctttata                                                   20


<210> 14095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAAGATT

<400> 14095
gaaaaatgta catcctttga                                                   20


<210> 14096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAAGATT

<400> 14096
atttaagtct ttaatccatc                                                   20


<210> 14097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGATT

<400> 14097
tcttccaggg tttttatagt                                                   20


<210> 14098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGTTT

<400> 14098
aggctgtctt ccagggtttt                                                   20


<210> 14099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGGGTTT

<400> 14099
gtattgccta ggctgtcttc                                                   20


<210> 14100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTTGCTT

<400> 14100
ttaatttttg tttttgttgc                                                   20


<210> 14101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 14101
attagatccc atttgttaat                                                   20


<210> 14102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGTTT

<400> 14102
cttttgctgt gcagaagctc                                                   20


<210> 14103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATAGTTT

<400> 14103
gactgtctgc ttactctgtt                                                   20


<210> 14104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCTGCTT

<400> 14104
tttctcccat tctgtagact                                                   20


<210> 14105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGATT

<400> 14105
gtaaactcat ttaagttcct                                                   20


<210> 14106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTTGTTT

<400> 14106
ctttgcccac tttttaatgg                                                   20


<210> 14107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTTGTTT

<400> 14107
cattgagctt tttttcatat                                                   20


<210> 14108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGCTT

<400> 14108
gtgacattga gctttttttc                                                   20


<210> 14109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGAGCTT

<400> 14109
ttctctaatg gtcagtgaca                                                   20


<210> 14110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGATT

<400> 14110
gagatggtat ctcattgtgg                                                   20


<210> 14111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGTTT

<400> 14111
ggtgtgagat ggtatctcat                                                   20


<210> 14112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGGGATT

<400> 14112
ctttaggtat atacccagta                                                   20


<210> 14113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTTGATT

<400> 14113
ctatcactga tggtcatttg                                                   20


<210> 14114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTCGTTT

<400> 14114
tgtccctgca aaggatatga                                                   20


<210> 14115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTAGTTT

<400> 14115
atttggtttt ctgttcctgc                                                   20


<210> 14116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGTTT

<400> 14116
ataagtgaga acatgtggta                                                   20


<210> 14117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACAGATT

<400> 14117
catgtcatag gggtttgttg                                                   20


<210> 14118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGGGTTT

<400> 14118
tacataggta aacatgtcat                                                   20


<210> 14119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGTTT

<400> 14119
cttatttatg gggtacaaaa                                                   20


<210> 14120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGCTT

<400> 14120
tcatttttaa ttgacaaaaa                                                   20


<210> 14121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGTTT

<400> 14121
ttgttctgta gtatgttttt                                                   20


<210> 14122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTATGTTT

<400> 14122
atcagggatc ttgttctgta                                                   20


<210> 14123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGTTT

<400> 14123
tcatttaatg ggctgttgca                                                   20


<210> 14124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGATT

<400> 14124
ctgaatctct tctgatgatc                                                   20


<210> 14125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGCTT

<400> 14125
aaaggttgtt gaaatttgtc                                                   20


<210> 14126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGTTT

<400> 14126
cctagctttt gttttctttt                                                   20


<210> 14127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 14127
tagcaacttc tatacctagc                                                   20


<210> 14128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTAGCTT

<400> 14128
aagttatagc aacttctata                                                   20


<210> 14129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGAGCTT

<400> 14129
aattgcaatt aaattgcaac                                                   20


<210> 14130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCCTGTTT

<400> 14130
gagaaaagga ggcagaacct                                                   20


<210> 14131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGGGATT

<400> 14131
cattgaatac gatgttagct                                                   20


<210> 14132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGTTT

<400> 14132
ctgatcttac aggaaagttt                                                   20


<210> 14133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAAGTTT

<400> 14133
tcttattcct gatcttacag                                                   20


<210> 14134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTTGTTT

<400> 14134
ttcagattgg gatgtctttt                                                   20


<210> 14135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGATT

<400> 14135
atctgtaaac acttttttct                                                   20


<210> 14136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACAGATT

<400> 14136
taaatttgtt tattagttct                                                   20


<210> 14137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 14137
tatccttcaa catctagtaa                                                   20


<210> 14138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGATT

<400> 14138
aaacgcaggt gatttttgta                                                   20


<210> 14139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGTGATT

<400> 14139
ttgttagtgt atagaaacgc                                                   20


<210> 14140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATTGTTT

<400> 14140
ctttcctaat tttctcttca                                                   20


<210> 14141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGATT

<400> 14141
atttctttcc taattttctc                                                   20


<210> 14142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGGGATT

<400> 14142
ttcttttgat gttatcataa                                                   20


<210> 14143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGTTT

<400> 14143
aatttccttc atgaacattt                                                   20


<210> 14144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGGGATT

<400> 14144
tattttagta aataatgcta                                                   20


<210> 14145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATTGCTT

<400> 14145
attttgttct tttttcttaa                                                   20


<210> 14146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAAGATT

<400> 14146
ttccattttg ttcttttttc                                                   20


<210> 14147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGATT

<400> 14147
aataaataag aaatgagaaa                                                   20


<210> 14148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGTTT

<400> 14148
ctggaggatc acttgtggcc                                                   20


<210> 14149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGCTT

<400> 14149
tggggactgg gtgcaatggc                                                   20


<210> 14150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGCTT

<400> 14150
gaccatacta ttttaattgt                                                   20


<210> 14151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 14151
cctgtttcat tggcctatat                                                   20


<210> 14152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCTGTTT

<400> 14152
gtttatttct gggctctcta                                                   20


<210> 14153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGGGTTT

<400> 14153
tatgagttaa ctatttatgc                                                   20


<210> 14154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGTTT

<400> 14154
tattttttta tatgtgaata                                                   20


<210> 14155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGAGTTT

<400> 14155
gtttaaatgt ttaatctatt                                                   20


<210> 14156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 14156
agttttcagg tcttaggttt                                                   20


<210> 14157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAGGTTT

<400> 14157
agttttacag ttttcaggtc                                                   20


<210> 14158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACAGTTT

<400> 14158
atgttttctt ctacaagttt                                                   20


<210> 14159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAAGTTT

<400> 14159
ttcctgctat gttttcttct                                                   20


<210> 14160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTATGTTT

<400> 14160
agtatcatga agctttcctg                                                   20


<210> 14161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGCTT

<400> 14161
cattgtcaag aacagtatca                                                   20


<210> 14162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGTTT

<400> 14162
tctcaattgt ctatttttgc                                                   20


<210> 14163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGTTT

<400> 14163
tccttttttt cccaaagctt                                                   20


<210> 14164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAAGCTT

<400> 14164
tgaatgcttc ctttttttcc                                                   20


<210> 14165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGCTT

<400> 14165
ggttgctttt tcaccctctt                                                   20


<210> 14166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTTGCTT

<400> 14166
atattttctc ccattctata                                                   20


<210> 14167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGATGATT

<400> 14167
cagtttttat ttgaattttc                                                   20


<210> 14168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACAGTTT

<400> 14168
ccactgcacc tggccctcat                                                   20


<210> 14169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGAGTTT

<400> 14169
ttttgtattt tcagtagaga                                                   20


<210> 14170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGATT

<400> 14170
tgcctcagct tcccaagtag                                                   20


<210> 14171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCAGCTT

<400> 14171
ggttcaagtg attctcctgc                                                   20


<210> 14172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGATT

<400> 14172
aacctccgac tccctggttc                                                   20


<210> 14173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGTTT

<400> 14173
ggccttgttg ctgtttgttt                                                   20


<210> 14174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGTTT

<400> 14174
gcccggcctt gttgctgttt                                                   20


<210> 14175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGTTT

<400> 14175
ccacgcccgg ccttgttgct                                                   20


<210> 14176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCTGTTT

<400> 14176
gccaccacgc ccggccttgt                                                   20


<210> 14177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGATT

<400> 14177
cgtctcggcc tcccaaagtg                                                   20


<210> 14178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGGGGTTT

<400> 14178
ttttgtattt ttagtagaga                                                   20


<210> 14179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGGAGTTT

<400> 14179
tgttgttttt ttttttgaga                                                   20


<210> 14180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGTTT

<400> 14180
tttttttttt tttttttttt                                                   20


<210> 14181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCTGTTT

<400> 14181
atctctttac ggttttttgt                                                   20


<210> 14182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACGGTTT

<400> 14182
ggtatgaaat gatatctctt                                                   20


<210> 14183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 14183
ttgatttggg tggtttttgt                                                   20


<210> 14184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 14184
tatcttttga tttgggtggt                                                   20


<210> 14185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTGGTTT

<400> 14185
acctattatc ttttgatttg                                                   20


<210> 14186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGATT

<400> 14186
ccttgccaac acctattatc                                                   20


<210> 14187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACTGTTT

<400> 14187
aattttttca ggaactttca                                                   20


<210> 14188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTTGTTT

<400> 14188
cattcatcaa tagacattta                                                   20


<210> 14189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGTGTTT

<400> 14189
tctttataag gctgaatagt                                                   20


<210> 14190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCAGGATT

<400> 14190
cattcaagtt gctgcatatg                                                   20


<210> 14191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGAGTTT

<400> 14191
ccattcttct ctctgtttcc                                                   20


<210> 14192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCTGTTT

<400> 14192
ctggcaatca ccattcttct                                                   20


<210> 14193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACCTGCTT

<400> 14193
ggaaacttaa tatgagatct                                                   20


<210> 14194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGCTT

<400> 14194
gctatgtaga agtacgtagt                                                   20


<210> 14195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGATT

<400> 14195
tttattttct gaccttttct                                                   20


<210> 14196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGCTT

<400> 14196
atttcatctt gcaatctaag                                                   20


<210> 14197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACTGATT

<400> 14197
caccaaagtc aggaaacagt                                                   20


<210> 14198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCTGCTT

<400> 14198
catccaattg actttaatct                                                   20


<210> 14199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACTGATT

<400> 14199
ttttacattt ataaagtgta                                                   20


<210> 14200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGATT

<400> 14200
caaatacaga tgtttatttt                                                   20


<210> 14201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGTTT

<400> 14201
atcctgacat ttacaaatac                                                   20


<210> 14202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCATGATT

<400> 14202
taccaaaatg tcattagtgt                                                   20


<210> 14203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTGGCTT

<400> 14203
agagaataat aattttgggt                                                   20


<210> 14204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGAGTTT

<400> 14204
gagataaagg agtctaattc                                                   20


<210> 14205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGATT

<400> 14205
ggtagaatct acagtattgc                                                   20


<210> 14206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGCTT

<400> 14206
ttagagggta gaatctacag                                                   20


<210> 14207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCCTGCTT

<400> 14207
ggaccaaaga ctatttcaga                                                   20


<210> 14208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGAGCTT

<400> 14208
agaattgctt tttctagaga                                                   20


<210> 14209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGCTT

<400> 14209
cattatggat ctagctccag                                                   20


<210> 14210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTAGTTT

<400> 14210
acatggcctg acagctaaaa                                                   20


<210> 14211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGATGTTT

<400> 14211
agaatatgga agcaggagat                                                   20


<210> 14212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGAGATT

<400> 14212
gtagggaaga atatggaagc                                                   20


<210> 14213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGTGTTT

<400> 14213
agaccttttt taatagcagc                                                   20


<210> 14214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAGGTTT

<400> 14214
tttggagaaa tagtaaaaga                                                   20


<210> 14215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAAGATT

<400> 14215
gctttcggtt ttgaagaaat                                                   20


<210> 14216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCGGTTT

<400> 14216
tcagggggga tagcaatgct                                                   20


<210> 14217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGCTT

<400> 14217
cagcaattca ggggggatag                                                   20


<210> 14218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAGGCTT

<400> 14218
atgaaatacg tgacaattga                                                   20


<210> 14219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATGGTTT

<400> 14219
aaaaatagat gctgctatag                                                   20


<210> 14220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTGGATT

<400> 14220
ctagtaagga tgccagtcac                                                   20


<210> 14221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTGGTTT

<400> 14221
ttctggtagc ccaggtgttt                                                   20


<210> 14222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGTGTTT

<400> 14222
cttccagctt ctggtagccc                                                   20


<210> 14223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGCTT

<400> 14223
aaatatattt tattgcctct                                                   20


<210> 14224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGGGCTT

<400> 14224
gaacaggata atacaaacct                                                   20


<210> 14225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTAGTTT

<400> 14225
ttaatcttca catcaactgt                                                   20


<210> 14226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGAGTTT

<400> 14226
agatatggtt cctgagctca                                                   20


<210> 14227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGAGCTT

<400> 14227
ttgtgtaata tatattgggt                                                   20


<210> 14228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAGGATT

<400> 14228
ttttttccaa tgtttcctat                                                   20


<210> 14229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGTTT

<400> 14229
atcaactatt ctgttttttc                                                   20


<210> 14230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGTTT

<400> 14230
tttgagcaat atatcaacta                                                   20


<210> 14231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAGGTTT

<400> 14231
ttatgattta ggttaaaccc                                                   20


<210> 14232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGATT

<400> 14232
aataataggt tctggctaac                                                   20


<210> 14233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGCTT

<400> 14233
tgactagtat acaattacaa                                                   20


<210> 14234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGATT

<400> 14234
aagtttaatt tgatatcaat                                                   20


<210> 14235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGTTT

<400> 14235
attttccaaa aaagataatg                                                   20


<210> 14236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACTGTTT

<400> 14236
cctatgttta cctaggatag                                                   20


<210> 14237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTATGTTT

<400> 14237
atgctatggc ttcttaaatc                                                   20


<210> 14238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATGGCTT

<400> 14238
atgttaaacc tcaacaatgc                                                   20


<210> 14239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGTGATT

<400> 14239
catgttgaat aaattgttaa                                                   20


<210> 14240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGATT

<400> 14240
ttaagccctt tgtagttatt                                                   20


<210> 14241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGATT

<400> 14241
caatatgagc acaaatatgc                                                   20


<210> 14242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGATT

<400> 14242
agttccatgc taagaaactt                                                   20


<210> 14243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGAGTTT

<400> 14243
tacagtttaa aacaccttgg                                                   20


<210> 14244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACAGTTT

<400> 14244
tgtatagctt ttactgtttt                                                   20


<210> 14245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACTGTTT

<400> 14245
taattttaat gtatagcttt                                                   20


<210> 14246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGCTT

<400> 14246
aaaataaaat aattttaatg                                                   20


<210> 14247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGCGCTT

<400> 14247
ttactaaatg ctcagtaaat                                                   20


<210> 14248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTAGTTT

<400> 14248
attaccttac cttcttgaga                                                   20


<210> 14249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCCTGATT

<400> 14249
gtacagcagt tggagataga                                                   20


<210> 14250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGTGATT

<400> 14250
aaaagcttct tagtttattt                                                   20


<210> 14251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTAGTTT

<400> 14251
aactttattt ttaaaagctt                                                   20


<210> 14252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGCTT

<400> 14252
tagcactaaa ctttattttt                                                   20


<210> 14253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGATT

<400> 14253
gtggattctg ttaatgtaag                                                   20


<210> 14254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTGGATT

<400> 14254
acgattatta tgtatgcagc                                                   20


<210> 14255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGACGATT

<400> 14255
aaaggcaact tttaagggat                                                   20


<210> 14256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGAGCTT

<400> 14256
gtttatggct attttagaat                                                   20


<210> 14257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCTGTTT

<400> 14257
gtaacattaa acagacaaaa                                                   20


<210> 14258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTAAGATT

<400> 14258
ttagaaataa ttaactggga                                                   20


<210> 14259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGTTT

<400> 14259
ccctttaaaa aatggagaaa                                                   20


<210> 14260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCTGCTT

<400> 14260
aaaatgaacg tttttgaact                                                   20


<210> 14261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAACGTTT

<400> 14261
tcaaatattg cttcaaaaat                                                   20


<210> 14262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGCTT

<400> 14262
cccatcttgc accattcaaa                                                   20


<210> 14263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCTGCTT

<400> 14263
tggcaggcgc ctgtaatcct                                                   20


<210> 14264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGTTT

<400> 14264
aaattgaaga taaaatactg                                                   20


<210> 14265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGTGCTT

<400> 14265
ttgtaagtgt cccatttcat                                                   20


<210> 14266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCTGCTT

<400> 14266
tgtcggactt ggttacctat                                                   20


<210> 14267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGTTT

<400> 14267
gtcaagttcc aaatcgttcc                                                   20


<210> 14268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACGGTTT

<400> 14268
tattaacacc acagatgggt                                                   20


<210> 14269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 14269
attcagcatc atgggagtaa                                                   20


<210> 14270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGCTT

<400> 14270
taacatctta ctaatcctaa                                                   20


<210> 14271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGCGGCTT

<400> 14271
tgatgtctta gatatttaag                                                   20


<210> 14272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTGGTTT

<400> 14272
taataaacat gagtcggctg                                                   20


<210> 14273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGCTT

<400> 14273
agagttcatg tcttattttg                                                   20


<210> 14274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGTTT

<400> 14274
ttaccttatc aataacaggt                                                   20


<210> 14275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAGGTTT

<400> 14275
acaagtttac cttatcaata                                                   20


<210> 14276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAAGTTT

<400> 14276
ttccagagtg tacagatttt                                                   20


<210> 14277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACAGATT

<400> 14277
tttctttttt ttccagagtg                                                   20


<210> 14278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGTTT

<400> 14278
tataaatata tatttttcat                                                   20


<210> 14279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGTTT

<400> 14279
ccacctacct gatatacacc                                                   20


<210> 14280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGATT

<400> 14280
tctaaaggat ttaaaccatt                                                   20


<210> 14281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGATT

<400> 14281
tcgtagaacc agccaaatct                                                   20


<210> 14282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAACGATT

<400> 14282
gagtaataat aataaattta                                                   20


<210> 14283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGCTT

<400> 14283
agcactatat atatttagtc                                                   20


<210> 14284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGATT

<400> 14284
gctgaaaagc agaaataaag                                                   20


<210> 14285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAAGATT

<400> 14285
taagatgaca ggtaggtttt                                                   20


<210> 14286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTAGGTTT

<400> 14286
gctgaagtgt aagatgacag                                                   20


<210> 14287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACCTGCTT

<400> 14287
tattttaaag catcttgaga                                                   20


<210> 14288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCTGATT

<400> 14288
gcaaaccttc tccctagatg                                                   20


<210> 14289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 14289
aagcctaaaa atatttataa                                                   20


<210> 14290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGTTT

<400> 14290
cttggaacac agccatacca                                                   20


<210> 14291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACCAGTTT

<400> 14291
tgttcttgga acacagccat                                                   20


<210> 14292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCCTGTTT

<400> 14292
ccaaaggtca acaaacccca                                                   20


<210> 14293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGTTT

<400> 14293
ccggaaagac agcacaacca                                                   20


<210> 14294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGTGCTT

<400> 14294
cacagaatag attgtgcaag                                                   20


<210> 14295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGATT

<400> 14295
cacatggtag ggaggcacag                                                   20


<210> 14296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCATGATT

<400> 14296
tgcctgtctt tctcagagac                                                   20


<210> 14297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTGGCTT

<400> 14297
taggctcttt agctttccca                                                   20


<210> 14298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGCTT

<400> 14298
ttgtttgagt ccttaggctc                                                   20


<210> 14299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTTGTTT

<400> 14299
tttgaggcat attgtagtca                                                   20


<210> 14300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCAGCTT

<400> 14300
tgcatttgag gcatattgta                                                   20


<210> 14301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGTTT

<400> 14301
aggtgaattg gatgcaggag                                                   20


<210> 14302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCTGTTT

<400> 14302
taagccagcc cactatttaa                                                   20


<210> 14303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGTGATT

<400> 14303
ccctacaaaa ccacttcctt                                                   20


<210> 14304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAAGTTT

<400> 14304
ctatctacaa gttgaaaatt                                                   20


<210> 14305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGATT

<400> 14305
ttccaagtat aaaagaaaga                                                   20


<210> 14306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACGGTTT

<400> 14306
attttaatta tccagtgtat                                                   20


<210> 14307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGGGTTT

<400> 14307
ccaggatggg gataagaaac                                                   20


<210> 14308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATCGCTT

<400> 14308
tagggaggct gaggcagaag                                                   20


<210> 14309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGTTT

<400> 14309
cagcttactg atactttaag                                                   20


<210> 14310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGCTT

<400> 14310
caatttaaca cggagattag                                                   20


<210> 14311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGGAGATT

<400> 14311
cttctctgag caatttaaca                                                   20


<210> 14312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 14312
cattatattg tattttactt                                                   20


<210> 14313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACCCGTTT

<400> 14313
cctgccctgt cccgacccta                                                   20


<210> 14314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGCTT

<400> 14314
tattttatgc ctctgttctg                                                   20


<210> 14315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGATT

<400> 14315
tactcctcta aaatttcttc                                                   20


<210> 14316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAGGATT

<400> 14316
caactaccat aacctagctt                                                   20


<210> 14317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTAGCTT

<400> 14317
atgaataaca actaccataa                                                   20


<210> 14318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGAGTTT

<400> 14318
tttgagaaaa ctaaagctca                                                   20


<210> 14319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 14319
atatcaggtg ttcaaataat                                                   20


<210> 14320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGTTT

<400> 14320
acacacagta tttcagtgca                                                   20


<210> 14321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGCTGTTT

<400> 14321
tctgtttaca taaatacata                                                   20


<210> 14322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGTTT

<400> 14322
atgtagaaat tatgagttgt                                                   20


<210> 14323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTTGTTT

<400> 14323
atgggtatgt agaaattatg                                                   20


<210> 14324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGGGTTT

<400> 14324
ataatgttct tattttttaa                                                   20


<210> 14325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTAGATT

<400> 14325
taagacctct aagagcctta                                                   20


<210> 14326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGAGCTT

<400> 14326
attaaatccc ttcggacact                                                   20


<210> 14327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAGGTTT

<400> 14327
ttaatgaaaa tgttattttt                                                   20


<210> 14328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGCTT

<400> 14328
tcagaattga ctttttcctt                                                   20


<210> 14329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGAGTTT

<400> 14329
ttcctgttga gttgctttta                                                   20


<210> 14330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTTGCTT

<400> 14330
ccatcttatt gttcctgttg                                                   20


<210> 14331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGCTT

<400> 14331
caaatagaat aaacaactta                                                   20


<210> 14332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCATGATT

<400> 14332
caaaagtgtg aaaagcatat                                                   20


<210> 14333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGATT

<400> 14333
ttaataagga attacaaagc                                                   20


<210> 14334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGATT

<400> 14334
accattgttc taattaaatt                                                   20


<210> 14335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGAGTTT

<400> 14335
atcacacact tcattttgac                                                   20


<210> 14336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTAGCTT

<400> 14336
tgaataccac acttttaggg                                                   20


<210> 14337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGGGCTT

<400> 14337
ttgagtgaat accacacttt                                                   20


<210> 14338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATAGATT

<400> 14338
taataagatt tatactaaga                                                   20


<210> 14339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGATT

<400> 14339
agtcttcaaa atgtttttta                                                   20


<210> 14340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 14340
ctcaaaatca tgagtcttca                                                   20


<210> 14341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGATT

<400> 14341
tcattctctc ttcagtacaa                                                   20


<210> 14342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGATT

<400> 14342
tgaagctctt attatatcta                                                   20


<210> 14343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGATT

<400> 14343
tgctttgtaa ctaaaatgtg                                                   20


<210> 14344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGCTT

<400> 14344
tctaaggtca tggaggagct                                                   20


<210> 14345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCAGTTT

<400> 14345
aaacacttcc cgcttcatca                                                   20


<210> 14346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCCGCTT

<400> 14346
gatgagcact ttaaaacact                                                   20


<210> 14347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGTAGCTT

<400> 14347
gtaatttatt ctgctaaata                                                   20


<210> 14348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGATT

<400> 14348
aaaacattaa aaaaaaaatt                                                   20


<210> 14349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGAGTTT

<400> 14349
attgggaatt aagttccaac                                                   20


<210> 14350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGTTT

<400> 14350
ggtgttcact gagagccaaa                                                   20


<210> 14351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTGGCTT

<400> 14351
tgtcataaaa ctcacttaac                                                   20


<210> 14352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGTGTTT

<400> 14352
gtatatttgt atatatacgt                                                   20


<210> 14353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTTGATT

<400> 14353
ttctgggtta tttgaaactt                                                   20


<210> 14354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCAGGCTT

<400> 14354
aatggacttg tctgatttct                                                   20


<210> 14355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCTGATT

<400> 14355
gctactcaga gaatggactt                                                   20


<210> 14356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGATT

<400> 14356
acagatgatt ctgttgtata                                                   20


<210> 14357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGATT

<400> 14357
atcattgtaa caagccctac                                                   20


<210> 14358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGCTGATT

<400> 14358
ggacacagat ttgggggagt                                                   20


<210> 14359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACAGATT

<400> 14359
cagagatgca aattttggga                                                   20


<210> 14360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGATGATT

<400> 14360
ttttatttga aaatttaaag                                                   20


<210> 14361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGTTT

<400> 14361
tatggctgtt taataatgga                                                   20


<210> 14362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGCTGTTT

<400> 14362
tattttaaat taagagatat                                                   20


<210> 14363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAGGTTT

<400> 14363
catcattcag tgtaagaaat                                                   20


<210> 14364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGATT

<400> 14364
agaagaaatt atagaaggaa                                                   20


<210> 14365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTAGTTT

<400> 14365
aatgggtatt tttgtaatat                                                   20


<210> 14366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGATT

<400> 14366
aattctaact tcggatatag                                                   20


<210> 14367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAGGTTT

<400> 14367
tacaccttat atgtgttatc                                                   20


<210> 14368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTCGTTT

<400> 14368
tcaaaaaaaa taataataat                                                   20


<210> 14369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGCTT

<400> 14369
tcgagatcgt gccactgcac                                                   20


<210> 14370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAGGTTT

<400> 14370
atcgcttgaa cccggtaggc                                                   20


<210> 14371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATCGCTT

<400> 14371
tcaggaggct gaggcagaag                                                   20


<210> 14372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGAGTTT

<400> 14372
caggtggatc acctgaggtc                                                   20


<210> 14373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGCTT

<400> 14373
tattcaaagc ttcataaact                                                   20


<210> 14374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAAGCTT

<400> 14374
tcaatttctc aactgttatt                                                   20


<210> 14375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGATT

<400> 14375
tgaattcata cagcatcata                                                   20


<210> 14376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCGAGCTT

<400> 14376
ttaaccaagg gtttgcatta                                                   20


<210> 14377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGGGTTT

<400> 14377
aagtgcttta aaatttaacc                                                   20


<210> 14378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGCTT

<400> 14378
gcaaatttgt atatgccaat                                                   20


<210> 14379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 14379
atcagtcata gtttttagag                                                   20


<210> 14380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGAGATT

<400> 14380
ctataatcag tcatagtttt                                                   20


<210> 14381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATAGTTT

<400> 14381
agaaacatcc tataatcagt                                                   20


<210> 14382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGTTT

<400> 14382
gattttcaga aacctaacct                                                   20


<210> 14383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTAGATT

<400> 14383
ctttatcttt tactaattct                                                   20


<210> 14384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATGGCTT

<400> 14384
acatattttg tattaattaa                                                   20


<210> 14385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGATT

<400> 14385
gtagaaatat ttttacaggc                                                   20


<210> 14386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAGGCTT

<400> 14386
aacgaagtag aaatattttt                                                   20


<210> 14387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGTTT

<400> 14387
tggaaaatac ataataattc                                                   20


<210> 14388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGATGATT

<400> 14388
cacagattaa agagaggaaa                                                   20


<210> 14389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACAGATT

<400> 14389
agatgataaa agggcagaga                                                   20


<210> 14390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGATT

<400> 14390
gagatgtgat tttttaaaaa                                                   20


<210> 14391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGATT

<400> 14391
ttatgttttc tgcaaaggag                                                   20


<210> 14392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGTTT

<400> 14392
aacatttata attgagtttt                                                   20


<210> 14393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGAGTTT

<400> 14393
tgacattgta acatttataa                                                   20


<210> 14394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAGGTTT

<400> 14394
gcttcatata ttttcaggct                                                   20


<210> 14395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAAGCTT

<400> 14395
attatcatat tttaattttg                                                   20


<210> 14396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAGGATT

<400> 14396
acttttgagt acattttaaa                                                   20


<210> 14397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTGGATT

<400> 14397
ttcaccaatg cctggtgttg                                                   20


<210> 14398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGCTT

<400> 14398
cacttacatc ttcattctgg                                                   20


<210> 14399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAAGATT

<400> 14399
tattgaaagg aaaaagacca                                                   20


<210> 14400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAGGCTT

<400> 14400
gaaacttgaa tattatttcc                                                   20


<210> 14401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCATGATT

<400> 14401
aatcatgaag cttaagttgt                                                   20


<210> 14402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGCTT

<400> 14402
tgtttttttt aaatgaatca                                                   20


<210> 14403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCTGTTT

<400> 14403
tagcattaga attgtatttt                                                   20


<210> 14404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGTTT

<400> 14404
tcagctggcc catgtcaata                                                   20


<210> 14405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGATT

<400> 14405
tcagagatca tgagtctttt                                                   20


<210> 14406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGTTT

<400> 14406
aaaggggagt gtaggatgtg                                                   20


<210> 14407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGCTT

<400> 14407
agaacagtga tttttagagc                                                   20


<210> 14408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGTGATT

<400> 14408
cattaatgga gagaatagaa                                                   20


<210> 14409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGTGTTT

<400> 14409
attttatcca acagggttaa                                                   20


<210> 14410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACAGTTT

<400> 14410
ttttcttcaa tattgatacc                                                   20


<210> 14411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCCTGATT

<400> 14411
agtttcggtt tagatggctt                                                   20


<210> 14412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATGGCTT

<400> 14412
attgccatag tttcggttta                                                   20


<210> 14413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCGGTTT

<400> 14413
gactgagtca ttgccatagt                                                   20


<210> 14414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATAGTTT

<400> 14414
ttcaaggact gagtcattgc                                                   20


<210> 14415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTCGTTT

<400> 14415
acaccagttc tagaaacagg                                                   20


<210> 14416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAGGCTT

<400> 14416
cctgtacacc agttctagaa                                                   20


<210> 14417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTTGCTT

<400> 14417
aagctgggta cagttttaaa                                                   20


<210> 14418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACAGTTT

<400> 14418
ttaccaatga tgaagctggg                                                   20


<210> 14419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGCTT

<400> 14419
aaccctgtga gattatgata                                                   20


<210> 14420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGAGATT

<400> 14420
tttaattttc aaacaaccct                                                   20


<210> 14421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGATT

<400> 14421
attgtgtttc agaatcttct                                                   20


<210> 14422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGTTT

<400> 14422
tctcatttag cttatactta                                                   20


<210> 14423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGCTT

<400> 14423
aaaagaagta atagctctca                                                   20


<210> 14424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACGTGTTT

<400> 14424
gtatagcaaa cccccatgac                                                   20


<210> 14425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTAGATT

<400> 14425
ttagacaggt tgccaattaa                                                   20


<210> 14426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGTGTTT

<400> 14426
ggaaagatat ttcaagaagc                                                   20


<210> 14427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGTTT

<400> 14427
agaggagatt acaaaaaaat                                                   20


<210> 14428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGAGATT

<400> 14428
tgtgactgag aatttcagag                                                   20


<210> 14429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGAGGTTT

<400> 14429
aatgtattcc tagtaactaa                                                   20


<210> 14430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGCTT

<400> 14430
aacaacctgc agggacccac                                                   20


<210> 14431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGAGCTT

<400> 14431
gatgtcacag ctgaggaaca                                                   20


<210> 14432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTGGATT

<400> 14432
gaatgagtgt gtacacatat                                                   20


<210> 14433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACATGTTT

<400> 14433
ggaaagtagc atgagtttca                                                   20


<210> 14434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGAGTTT

<400> 14434
acttatgtgt ggaaagtagc                                                   20


<210> 14435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGTGCTT

<400> 14435
ggatgctggc agaagatatg                                                   20


<210> 14436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACTGTTT

<400> 14436
atgctaatag gttgatctga                                                   20


<210> 14437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGATT

<400> 14437
acagtcttca tgagtttgga                                                   20


<210> 14438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGAGTTT

<400> 14438
ttgcctcata gacagtcttc                                                   20


<210> 14439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGAAGTTT

<400> 14439
atctagctag atataccact                                                   20


<210> 14440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCAGCTT

<400> 14440
ctcattcttg tacacataca                                                   20


<210> 14441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAAGTTT

<400> 14441
agttttagga taaaagtagg                                                   20


<210> 14442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTAGTTT

<400> 14442
tataaaaagg gaaaacagat                                                   20


<210> 14443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCAGCTT

<400> 14443
agatactatg agaaagcaag                                                   20


<210> 14444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGTGCTT

<400> 14444
tgcaatttca gaaacgtaaa                                                   20


<210> 14445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACTGCTT

<400> 14445
agttctgtag caaggagaac                                                   20


<210> 14446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGTTT

<400> 14446
tgagtaactg tagagcttgg                                                   20


<210> 14447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGAGCTT

<400> 14447
agaatacaaa tgagtaactg                                                   20


<210> 14448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACTGTTT

<400> 14448
aaagataaat aagatccagg                                                   20


<210> 14449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGAGCTT

<400> 14449
ggagtaatgt tttgtaccct                                                   20


<210> 14450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGTTT

<400> 14450
gagaattata attcttggag                                                   20


<210> 14451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCAGCTT

<400> 14451
actaatttca agttacaaca                                                   20


<210> 14452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAGGTTT

<400> 14452
acaattagtc ctagagtgta                                                   20


<210> 14453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAGGTTT

<400> 14453
tagaacaaag agagaaggtt                                                   20


<210> 14454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCAGTTT

<400> 14454
aagagaattt tactggcaat                                                   20


<210> 14455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTATGATT

<400> 14455
gttttaccta gaattaatcc                                                   20


<210> 14456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTTGTTT

<400> 14456
aagataaaaa tatcatggca                                                   20


<210> 14457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGATT

<400> 14457
atctgacacc taagtcaata                                                   20


<210> 14458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAAGCTT

<400> 14458
ttgttgaaca cagttggttt                                                   20


<210> 14459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTGGTTT

<400> 14459
ctacaagatt gttgaacaca                                                   20


<210> 14460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAAGATT

<400> 14460
gaacatcagg aaaacctgct                                                   20


<210> 14461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAAGATT

<400> 14461
aattttattt attctgaata                                                   20


<210> 14462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCAGTTT

<400> 14462
gttgagggag tatcacagaa                                                   20


<210> 14463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGGGATT

<400> 14463
ggaggagact gaagagaaat                                                   20


<210> 14464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTGGTTT

<400> 14464
tcattcacac ataaaatgaa                                                   20


<210> 14465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGATT

<400> 14465
accctaaaat tcatgtcgtc                                                   20


<210> 14466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGGGTTT

<400> 14466
gtttagaaag gtgtatttca                                                   20


<210> 14467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGTTT

<400> 14467
gtttccacta attttctcaa                                                   20


<210> 14468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGAGTTT

<400> 14468
tttcttttga acttaatttc                                                   20


<210> 14469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGAGTTT

<400> 14469
atctggatct tctaatcaag                                                   20


<210> 14470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACAGTTT

<400> 14470
ttttaactta gaatacttga                                                   20


<210> 14471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 14471
acataaaaat ttaaagtcac                                                   20


<210> 14472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGGGTTT

<400> 14472
atacataaaa gatacgtaac                                                   20


<210> 14473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGTTT

<400> 14473
atctagttat agtcatttat                                                   20


<210> 14474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATTGATT

<400> 14474
tcaagaaata agccaggtga                                                   20


<210> 14475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGAGATT

<400> 14475
tttctcaaga aataagccag                                                   20


<210> 14476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGATT

<400> 14476
caaactcttt tttactgata                                                   20


<210> 14477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTGGTTT

<400> 14477
tgcttgcatc acaattctaa                                                   20


<210> 14478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGCTT

<400> 14478
acccttgcct cttgtgtaca                                                   20


<210> 14479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGCTT

<400> 14479
aaactcctta aggtaaaggc                                                   20


<210> 14480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCCTGCTT

<400> 14480
tgcaatttgc gtatctcgtt                                                   20


<210> 14481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATGGTTT

<400> 14481
ggatactgga ccagaatcca                                                   20


<210> 14482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCTGATT

<400> 14482
tccaatcaat caccaaatcc                                                   20


<210> 14483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGTTT

<400> 14483
gccgagtcag ctcctcctcc                                                   20


<210> 14484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCCGTTT

<400> 14484
ttcttttcta gacaggtttt                                                   20


<210> 14485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAGGTTT

<400> 14485
tactaagaat tcttttctag                                                   20


<210> 14486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGTTT

<400> 14486
cccttaatat tgttgtttca                                                   20


<210> 14487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGTTT

<400> 14487
tgaattctct cccttaatat                                                   20


<210> 14488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCTGCTT

<400> 14488
taacaacaag aattggtatg                                                   20


<210> 14489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GACAGTTT

<400> 14489
acagacaagc aggaatttct                                                   20


<210> 14490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGCTGCTT

<400> 14490
atagtcaaat atttaataat                                                   20


<210> 14491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTAAGTTT

<400> 14491
ttaaggtaag ttatagaatt                                                   20


<210> 14492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGATT

<400> 14492
ttgctaaatg cagagttaag                                                   20


<210> 14493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACTGATT

<400> 14493
aatgtaaaga ttcccaccat                                                   20


<210> 14494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGATT

<400> 14494
gcttggagat ttttgtaatg                                                   20


<210> 14495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGAGATT

<400> 14495
aagctctcat ttgtagtgct                                                   20


<210> 14496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGTGCTT

<400> 14496
aatcaagaag ctctcatttg                                                   20


<210> 14497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCTGTTT

<400> 14497
acaatacacc ttgactgttt                                                   20


<210> 14498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GACTGTTT

<400> 14498
ctacaaacac aatacacctt                                                   20


<210> 14499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GACTGCTT

<400> 14499
aagtatagtt ttagcatgaa                                                   20


<210> 14500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGTTT

<400> 14500
ttttgcagct aataaacaag                                                   20


<210> 14501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGCTT

<400> 14501
atatcaaatt gtttctcaaa                                                   20


<210> 14502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGTTT

<400> 14502
attgaacatt ctgtatatca                                                   20


<210> 14503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAAGTTT

<400> 14503
atctctcatt tcatctactt                                                   20


<210> 14504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGTTT

<400> 14504
tcttataaaa ctttttactc                                                   20


<210> 14505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCTGTTT

<400> 14505
tgggcctctt atgttcatag                                                   20


<210> 14506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGTTT

<400> 14506
ttaaattgat taaaattttt                                                   20


<210> 14507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGATT

<400> 14507
agttgcttta ataaacttta                                                   20


<210> 14508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTTGCTT

<400> 14508
cttttcttca gagtaattct                                                   20


<210> 14509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAGGTTT

<400> 14509
cctcctgcct tcatctaaaa                                                   20


<210> 14510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGTTT

<400> 14510
caatacttgt taatgaatta                                                   20


<210> 14511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGATT

<400> 14511
gttgttttag aacatacaac                                                   20


<210> 14512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGTTT

<400> 14512
tgtcaagagg attctagttt                                                   20


<210> 14513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTAGTTT

<400> 14513
gtgcatcttg tcaagaggat                                                   20


<210> 14514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAGGATT

<400> 14514
ctaccaggtg catcttgtca                                                   20


<210> 14515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGATT

<400> 14515
aattagactt cagaaacatg                                                   20


<210> 14516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTTGTTT

<400> 14516
cataggggga gagggaaaca                                                   20


<210> 14517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCAGTTT

<400> 14517
caaagagcaa gcattacaga                                                   20


<210> 14518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAAGATT

<400> 14518
caaattatga ctaactgctt                                                   20


<210> 14519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACTGCTT

<400> 14519
taacctttca aattatgact                                                   20


<210> 14520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGTTT

<400> 14520
cttttttttt ctttttcatc                                                   20


<210> 14521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGATT

<400> 14521
attgtataaa tgaagctatg                                                   20


<210> 14522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCTGTTT

<400> 14522
tttttgaccc taccctttta                                                   20


<210> 14523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGATT

<400> 14523
ggtattttta ttttccctga                                                   20


<210> 14524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAAGTTT

<400> 14524
cttatatgtg atcattgttt                                                   20


<210> 14525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGTTT

<400> 14525
aattctttct tatatgtgat                                                   20


<210> 14526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAAGATT

<400> 14526
aataatgttt cccttcaatt                                                   20


<210> 14527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGTTT

<400> 14527
tatttcctca atcataagaa                                                   20


<210> 14528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGTGTTT

<400> 14528
acttttctaa ttaggatttt                                                   20


<210> 14529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAGGATT

<400> 14529
aagtttacta acttttctaa                                                   20


<210> 14530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAAGTTT

<400> 14530
atgaaacttc atttcagatt                                                   20


<210> 14531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGATT

<400> 14531
caatatttat gaaacttcat                                                   20


<210> 14532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACCAGCTT

<400> 14532
aaggtatgat aacattgcta                                                   20


<210> 14533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGTTT

<400> 14533
aatgtttgag agattctctg                                                   20


<210> 14534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGAGATT

<400> 14534
tgggacccat taaaatgttt                                                   20


<210> 14535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 14535
ttactcactg ggacccatta                                                   20


<210> 14536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGTTT

<400> 14536
tttttttttt ttttgagagc                                                   20


<210> 14537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGAGCTT

<400> 14537
tttttttttt tttttttttt                                                   20


<210> 14538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTGGTTT

<400> 14538
gtctgtcttt tgaagtggtc                                                   20


<210> 14539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATGGTTT

<400> 14539
aattatattg atcatgctgt                                                   20


<210> 14540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTTGTTT

<400> 14540
gttaagaaat ggtgaaaaaa                                                   20


<210> 14541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGCTT

<400> 14541
tgatgttaag aaatggtgaa                                                   20


<210> 14542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 14542
gaaagataat gttaacaaat                                                   20


<210> 14543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 14543
gccaaatcat cttcctttca                                                   20


<210> 14544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATCGCTT

<400> 14544
tcaagaggct gaggcaggag                                                   20


<210> 14545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCCGTTT

<400> 14545
tcctggctaa catggtgaaa                                                   20


<210> 14546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAGGATT

<400> 14546
caaattagta aattacataa                                                   20


<210> 14547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGATT

<400> 14547
tggttttata ttgtgctgct                                                   20


<210> 14548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCTGCTT

<400> 14548
gtctatgtgg ttttatattg                                                   20


<210> 14549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGTTT

<400> 14549
gacatgactc tttgggtcta                                                   20


<210> 14550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GACTGCTT

<400> 14550
ctttgtattt gaagacttca                                                   20


<210> 14551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGATT

<400> 14551
atcactttac taatgtattt                                                   20


<210> 14552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGCTT

<400> 14552
tctcacattt gttgattcat                                                   20


<210> 14553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGATT

<400> 14553
gttgttcata gtctcacatt                                                   20


<210> 14554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAACGATT

<400> 14554
tttactgaag ataaatgtta                                                   20


<210> 14555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCATGTTT

<400> 14555
aaaagaatta aatccaagta                                                   20


<210> 14556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGTTT

<400> 14556
gaatcaatgc cagttcagag                                                   20


<210> 14557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACATGTTT

<400> 14557
gtcagaatga agaatcatga                                                   20


<210> 14558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGGGCTT

<400> 14558
ccacatgaag actgagaagc                                                   20


<210> 14559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATAGTTT

<400> 14559
gtgcttaaaa actggaaatg                                                   20


<210> 14560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGGTGCTT

<400> 14560
ttgttgatgg attgaacatt                                                   20


<210> 14561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATGGATT

<400> 14561
tagagctgaa gggatttgtt                                                   20


<210> 14562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGGGATT

<400> 14562
atattttgaa gttagagctg                                                   20


<210> 14563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGAGTTT

<400> 14563
gggagcttag actagtatgg                                                   20


<210> 14564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGGAGCTT

<400> 14564
aaatccaggt gagaggtgat                                                   20


<210> 14565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGAGTTT

<400> 14565
gcagaagctg gaagatttct                                                   20


<210> 14566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGAAGATT

<400> 14566
gaatagcaat ggcagaagct                                                   20


<210> 14567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGATT

<400> 14567
atttgaagaa cattataagg                                                   20


<210> 14568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCCAGATT

<400> 14568
agatcagaga tgtagtagag                                                   20


<210> 14569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCAAGATT

<400> 14569
gaggcagagg ttgcagtgag                                                   20


<210> 14570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAGGATT

<400> 14570
gagaataatg aaagatggga                                                   20


<210> 14571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGCGTTT

<400> 14571
agaaagcctg cctataaagg                                                   20


<210> 14572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGATT

<400> 14572
cacataaata tgctatcaat                                                   20


<210> 14573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGCTT

<400> 14573
taaattcagt gaagcagcca                                                   20


<210> 14574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGCTT

<400> 14574
aaacacattt tccaatgaac                                                   20


<210> 14575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGCTT

<400> 14575
gtgaatactc tgagattatt                                                   20


<210> 14576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGAGATT

<400> 14576
aaaatacttt tgtgaatact                                                   20


<210> 14577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAAGTTT

<400> 14577
tgttataata agatataata                                                   20


<210> 14578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGTTT

<400> 14578
gttgggctta tcaatcaact                                                   20


<210> 14579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGGGCTT

<400> 14579
ctaggataac tagaaagaag                                                   20


<210> 14580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCAAGATT

<400> 14580
ttaaatttgt attgatgcta                                                   20


<210> 14581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGAGATT

<400> 14581
ctttaaaagt gtccatgtta                                                   20


<210> 14582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACAGTTT

<400> 14582
attagtgcta taagcaaatg                                                   20


<210> 14583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGCTT

<400> 14583
acatccagtc aatataaatt                                                   20


<210> 14584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATGGATT

<400> 14584
tcagcaaact acaaagagtg                                                   20


<210> 14585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGATT

<400> 14585
taacattcat gggttaagca                                                   20


<210> 14586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTGGTTT

<400> 14586
cagtgtccaa gattttctca                                                   20


<210> 14587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCAAGATT

<400> 14587
catcgacttg ctttcagtgt                                                   20


<210> 14588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTTGCTT

<400> 14588
tattttttga aaaatcatcg                                                   20


<210> 14589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGGGCTT

<400> 14589
tgctaatgac ttatctagtc                                                   20


<210> 14590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAGGATT

<400> 14590
cttctacttt tcttattctt                                                   20


<210> 14591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGATT

<400> 14591
gctaagagga tcaaataaga                                                   20


<210> 14592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTATGCTT

<400> 14592
cagtacctcc ttctactcct                                                   20


<210> 14593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGTTT

<400> 14593
ctttacattt ggccttagtc                                                   20


<210> 14594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAGGATT

<400> 14594
agatagggcc caagccctta                                                   20


<210> 14595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGTTT

<400> 14595
taaagacttt gagagaccct                                                   20


<210> 14596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACAGCTT

<400> 14596
aacaaaactt tagtatggtt                                                   20


<210> 14597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATGGTTT

<400> 14597
aaacaaaaac aaaactttag                                                   20


<210> 14598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGTTT

<400> 14598
tgtaaaacat tccaagttta                                                   20


<210> 14599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCAAGTTT

<400> 14599
tctgttgttt gtaaaacatt                                                   20


<210> 14600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGTTT

<400> 14600
ccccattggt catcaccatc                                                   20


<210> 14601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCTGCTT

<400> 14601
acctcactct tgagtcccag                                                   20


<210> 14602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGCTT

<400> 14602
tgaggtgttt catgcatgcc                                                   20


<210> 14603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGTGTTT

<400> 14603
tttcttattc tgaagctctg                                                   20


<210> 14604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGATT

<400> 14604
ttttctgcac atcctgtaaa                                                   20


<210> 14605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTAGTTT

<400> 14605
ctctcaaaat tcttcctttc                                                   20


<210> 14606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACTGTTT

<400> 14606
ctactcacta actctcagaa                                                   20


<210> 14607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGAGTTT

<400> 14607
gtcactagag ctctctaagc                                                   20


<210> 14608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTAAGCTT

<400> 14608
gggcaagtca ctagagctct                                                   20


<210> 14609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGATGATT

<400> 14609
ctgattcagc tatagctgta                                                   20


<210> 14610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCTGATT

<400> 14610
agtcagaaga ctccattcca                                                   20


<210> 14611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGGGTTT

<400> 14611
gcattcctta attagtgttc                                                   20


<210> 14612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCCTGTTT

<400> 14612
tgaattccga tgagccagag                                                   20


<210> 14613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGAGATT

<400> 14613
tggggtggtg aattcctttc                                                   20


<210> 14614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAGGCTT

<400> 14614
gcatgagtct gattattaaa                                                   20


<210> 14615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCTGATT

<400> 14615
tttcataata ctttgcatga                                                   20


<210> 14616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGTTT

<400> 14616
taaggttact tgacctcaat                                                   20


<210> 14617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGTTT

<400> 14617
tgttagtata ataaacataa                                                   20


<210> 14618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGATT

<400> 14618
gggtataggt tgtcctcaaa                                                   20


<210> 14619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGAGCTT

<400> 14619
ttttttgcca actatttgat                                                   20


<210> 14620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGTTT

<400> 14620
ttaaaaaatt ttaactatca                                                   20


<210> 14621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGATT

<400> 14621
cattttgatt tcaaaaccgt                                                   20


<210> 14622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGATT

<400> 14622
tgttggtatg gtcattggca                                                   20


<210> 14623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACTGTTT

<400> 14623
tttcttgaca ttataaataa                                                   20


<210> 14624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGTGCTT

<400> 14624
tttgtttcag agtttgcatg                                                   20


<210> 14625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGAGTTT

<400> 14625
attttcttcg atctttgttt                                                   20


<210> 14626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGTTT

<400> 14626
catgtttaat tttcttcgat                                                   20


<210> 14627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCATGTTT

<400> 14627
ttattccatg tgtaagtctg                                                   20


<210> 14628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGATT

<400> 14628
gttgctgtat gtattttttg                                                   20


<210> 14629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGAGTTT

<400> 14629
acaatatttg ggaaatttga                                                   20


<210> 14630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCTGCTT

<400> 14630
aattaactct tccattgata                                                   20


<210> 14631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTAGCTT

<400> 14631
agaattgtgt tgtagtaact                                                   20


<210> 14632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTTGCTT

<400> 14632
ttattatttt tagcacttgc                                                   20


<210> 14633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATAGATT

<400> 14633
ctatcatatt aatacaaatt                                                   20


<210> 14634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGATT

<400> 14634
caatctctaa aagtcaaacc                                                   20


<210> 14635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTAGCTT

<400> 14635
tggtacccat caagaatact                                                   20


<210> 14636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCTGCTT

<400> 14636
ccagttataa gaaagacatt                                                   20


<210> 14637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATAGATT

<400> 14637
gaataatgcc tctaggccaa                                                   20


<210> 14638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACATGTTT

<400> 14638
gaattcaatc agtttaaata                                                   20


<210> 14639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCAGTTT

<400> 14639
aactaattta gatgaattca                                                   20


<210> 14640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGTTT

<400> 14640
ttatacttta aagcctattc                                                   20


<210> 14641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGTTT

<400> 14641
atatatttta aaactcattc                                                   20


<210> 14642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTGGATT

<400> 14642
aagtttatcc aacatcgttt                                                   20


<210> 14643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATCGTTT

<400> 14643
gtaattataa gtttatccaa                                                   20


<210> 14644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGTTT

<400> 14644
caaaatacat attagtaatt                                                   20


<210> 14645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGATT

<400> 14645
tagtcttcta aatatggtac                                                   20


<210> 14646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACTGCTT

<400> 14646
tttctatcag caattcctct                                                   20


<210> 14647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGGTGCTT

<400> 14647
tattgtgtct aatagcaggg                                                   20


<210> 14648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGCTT

<400> 14648
aaccaattat tgatgtttga                                                   20


<210> 14649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGATGTTT

<400> 14649
acagtgagaa aaccaattat                                                   20


<210> 14650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGTTT

<400> 14650
cataaaacct gcatatgaaa                                                   20


<210> 14651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACTGTTT

<400> 14651
atatacagta tggaaatagt                                                   20


<210> 14652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCATGCTT

<400> 14652
gaactgtcta tattgctaaa                                                   20


<210> 14653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGATT

<400> 14653
gaagcttata ctgtagcaag                                                   20


<210> 14654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAAGCTT

<400> 14654
ttctcttaga aatctgctaa                                                   20


<210> 14655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGAGTTT

<400> 14655
gaaaactaaa caacagatga                                                   20


<210> 14656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGATT

<400> 14656
tacatggaaa actaaacaac                                                   20


<210> 14657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTATGCTT

<400> 14657
gtgagtccac cttcttgatc                                                   20


<210> 14658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGATT

<400> 14658
gaatgctaat tatggtacac                                                   20


<210> 14659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 14659
taaatactat tatacattta                                                   20


<210> 14660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTCGATT

<400> 14660
cctctctctc tttttctctc                                                   20


<210> 14661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATTGTTT

<400> 14661
aagtttacaa tcaagataag                                                   20


<210> 14662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAGGATT

<400> 14662
acataagttt acaatcaaga                                                   20


<210> 14663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGTTT

<400> 14663
ggagcatctt aaatagctac                                                   20


<210> 14664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGCTT

<400> 14664
gggaaaacca tgaagaataa                                                   20


<210> 14665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACAGCTT

<400> 14665
tcaagcagta tagtagaaaa                                                   20


<210> 14666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGTTT

<400> 14666
atgaaatagg cttacatcgt                                                   20


<210> 14667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAGGCTT

<400> 14667
atcatccatg atagcatgaa                                                   20


<210> 14668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTAGATT

<400> 14668
gatagtttct tcttttgagc                                                   20


<210> 14669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATAGTTT

<400> 14669
tgtacagtgc tgctgtgttt                                                   20


<210> 14670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGTTT

<400> 14670
ctgtgttttg tacagtgctg                                                   20


<210> 14671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGTTT

<400> 14671
agtaaggttt ttgttgagtt                                                   20


<210> 14672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAGGTTT

<400> 14672
catcaatcat tctctttgag                                                   20


<210> 14673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACAGTTT

<400> 14673
tttttttgtt gtgtgaagca                                                   20


<210> 14674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGCTT

<400> 14674
atacccatct cctccttttg                                                   20


<210> 14675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGATT

<400> 14675
cttttatacc catctcctcc                                                   20


<210> 14676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTAGTTT

<400> 14676
cttattaaca gataatggag                                                   20


<210> 14677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGAGCTT

<400> 14677
tcttgcttat taacagataa                                                   20


<210> 14678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGCTT

<400> 14678
aactaatttt aaaatgtctt                                                   20


<210> 14679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGATT

<400> 14679
aaatttacta ttttactcct                                                   20


<210> 14680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGATT

<400> 14680
tatgccacat agtaactatg                                                   20


<210> 14681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGATT

<400> 14681
aggaaaaaaa taaaggccct                                                   20


<210> 14682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGATT

<400> 14682
aatctaaatc atgttaagaa                                                   20


<210> 14683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGATT

<400> 14683
agaaatttca tatcaaaaaa                                                   20


<210> 14684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGTGATT

<400> 14684
ttcctgaaat tcctgagctt                                                   20


<210> 14685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGAGCTT

<400> 14685
ccattttttt cctgaaattc                                                   20


<210> 14686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGAGTTT

<400> 14686
gacaacagaa gaaaatacag                                                   20


<210> 14687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGTTT

<400> 14687
ccttttttta aaaaaagagc                                                   20


<210> 14688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTGGTTT

<400> 14688
aaaataggaa aggaaaaaaa                                                   20


<210> 14689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGTGTTT

<400> 14689
gttgaccttg tgatggaact                                                   20


<210> 14690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGAGATT

<400> 14690
ctgaatttct ctggtggtgg                                                   20


<210> 14691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTGGTTT

<400> 14691
gaagaggtct ccgtgaaatc                                                   20


<210> 14692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAAGATT

<400> 14692
ggatagaaag tgccctaggt                                                   20


<210> 14693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTAAGTTT

<400> 14693
atatcttatc atttagtcac                                                   20


<210> 14694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGATT

<400> 14694
ggccaactgt tgttgctttt                                                   20


<210> 14695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGCTT

<400> 14695
cttcttacat ggccaactgt                                                   20


<210> 14696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGCTT

<400> 14696
ttctcttctt ttcattagaa                                                   20


<210> 14697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGCTT

<400> 14697
gccactttac actcctagct                                                   20


<210> 14698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCTGCTT

<400> 14698
gacttgaccc actgtattcc                                                   20


<210> 14699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGCTT

<400> 14699
aatagcaaaa ttgtttaaat                                                   20


<210> 14700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 14700
cataaatagc aaaattgttt                                                   20


<210> 14701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGTTT

<400> 14701
taagctggca taaatagcaa                                                   20


<210> 14702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGTTT

<400> 14702
tgcgtatcta cactttgcct                                                   20


<210> 14703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGAAGCTT

<400> 14703
aaaattatag ataatattta                                                   20


<210> 14704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGTTT

<400> 14704
actttgtgtt tgtcattctt                                                   20


<210> 14705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGTTT

<400> 14705
gcttactttg tgtttgtcat                                                   20


<210> 14706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGTTT

<400> 14706
agatatctag gtagcttact                                                   20


<210> 14707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTAGCTT

<400> 14707
agaaatgatt cagatatcta                                                   20


<210> 14708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGATT

<400> 14708
gtagtattag tagttaacag                                                   20


<210> 14709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACATGTTT

<400> 14709
attttcaata ttagaaatcc                                                   20


<210> 14710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGTTT

<400> 14710
acatataaac atatgcatat                                                   20


<210> 14711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGGGATT

<400> 14711
tttttctatt tcaaatttgg                                                   20


<210> 14712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGTTT

<400> 14712
aaaattagtt attttagtgt                                                   20


<210> 14713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACAGTTT

<400> 14713
accttagaga taatattgct                                                   20


<210> 14714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGTTT

<400> 14714
gaatttctct gtcattgttg                                                   20


<210> 14715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACAGATT

<400> 14715
acacttttac tgaaattaga                                                   20


<210> 14716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAGGTTT

<400> 14716
agatcagtct ctagaaacta                                                   20


<210> 14717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGATT

<400> 14717
actcattgat aagaataagt                                                   20


<210> 14718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGTTT

<400> 14718
aatattactc attgataaga                                                   20


<210> 14719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 14719
gaataagtga taagtgttca                                                   20


<210> 14720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGATT

<400> 14720
aaatcaactc agtaattaac                                                   20


<210> 14721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATGGTTT

<400> 14721
aaactttgaa tacattttga                                                   20


<210> 14722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCCTGCTT

<400> 14722
ttggggtcaa agccaaagta                                                   20


<210> 14723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGCTT

<400> 14723
atggataagc aaattgagac                                                   20


<210> 14724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTAGCTT

<400> 14724
caggaaaaga tcattgtaat                                                   20


<210> 14725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGTTT

<400> 14725
actctaaaaa attgtggaag                                                   20


<210> 14726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCTGATT

<400> 14726
aaacctctat caacttccct                                                   20


<210> 14727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGATT

<400> 14727
tgatctgtag atttttattg                                                   20


<210> 14728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGATT

<400> 14728
gtgatttcaa gtgcatgatc                                                   20


<210> 14729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGATT

<400> 14729
gatgtaacct tcatgtgctt                                                   20


<210> 14730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGCTT

<400> 14730
gacttcttga tgtaaccttc                                                   20


<210> 14731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGATT

<400> 14731
agggcaattt gattattttt                                                   20


<210> 14732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGATT

<400> 14732
cacagcatgt caccagggca                                                   20


<210> 14733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGCTT

<400> 14733
gatcagtcaa ggatgcagct                                                   20


<210> 14734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGCTT

<400> 14734
ttagtactgt gattcaaata                                                   20


<210> 14735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGATT

<400> 14735
aatgacattt aatcttagta                                                   20


<210> 14736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATTGTTT

<400> 14736
aattatgtaa ctgtttaatt                                                   20


<210> 14737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGATT

<400> 14737
gtagaattat gtaactgttt                                                   20


<210> 14738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACTGTTT

<400> 14738
atagtagagt agaattatgt                                                   20


<210> 14739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGCTT

<400> 14739
gagaatcact tatatttaaa                                                   20


<210> 14740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGCTT

<400> 14740
caagaaatgc taattttaga                                                   20


<210> 14741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCTGTTT

<400> 14741
gaaacttcac ttttttgcaa                                                   20


<210> 14742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 14742
aatctttcca tcttcattgg                                                   20


<210> 14743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTGGATT

<400> 14743
tgaaaaatct ttccatcttc                                                   20


<210> 14744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTTGTTT

<400> 14744
tagaccattt gtttttttca                                                   20


<210> 14745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 14745
tgtagaattg cacttagacc                                                   20


<210> 14746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATAGATT

<400> 14746
atttgattct atattttatg                                                   20


<210> 14747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGATT

<400> 14747
tgctgtttcg taaaattggc                                                   20


<210> 14748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCTGTTT

<400> 14748
ttagggatta gttacagtta                                                   20


<210> 14749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGGGATT

<400> 14749
gcatttgact ttgaaagatt                                                   20


<210> 14750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAAGATT

<400> 14750
ttaaaaatgc atttgacttt                                                   20


<210> 14751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGCTT

<400> 14751
atcaaagttt tagatttacc                                                   20


<210> 14752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGATT

<400> 14752
tttagatttt taatcaaagt                                                   20


<210> 14753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAAGTTT

<400> 14753
tctctcttta gatttttaat                                                   20


<210> 14754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGATT

<400> 14754
tgttatcaag actttctctc                                                   20


<210> 14755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTGGTTT

<400> 14755
ttaatgtcct tttactatgt                                                   20


<210> 14756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTTGTTT

<400> 14756
attttgttga cctgataaaa                                                   20


<210> 14757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGCTT

<400> 14757
ttatctttgg agatacttaa                                                   20


<210> 14758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGTTT

<400> 14758
acccattcat ctattcagtg                                                   20


<210> 14759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACCTGATT

<400> 14759
aacaagcatt catattgttc                                                   20


<210> 14760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGCTT

<400> 14760
caacaaaaag tatacactct                                                   20


<210> 14761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGGTGATT

<400> 14761
tcatgtactt caaaggtaaa                                                   20


<210> 14762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGAGTTT

<400> 14762
gcccagaatt ataataggca                                                   20


<210> 14763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCATGCTT

<400> 14763
gaaggtatta acaaggtcag                                                   20


<210> 14764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTGGATT

<400> 14764
tattgctacc ctgaataaaa                                                   20


<210> 14765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGCTT

<400> 14765
cccagagatc cttatccaac                                                   20


<210> 14766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACAGCTT

<400> 14766
ttagaggtga ctgttccacc                                                   20


<210> 14767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTATGATT

<400> 14767
tttttcttct atattaatgc                                                   20


<210> 14768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGTTT

<400> 14768
tcccttctgc caatcttcac                                                   20


<210> 14769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGTTT

<400> 14769
tggcataact ggatagaaca                                                   20


<210> 14770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCTGTTT

<400> 14770
tggctatttc tgagtcagga                                                   20


<210> 14771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGTGTTT

<400> 14771
taatccctat ttttttgtgt                                                   20


<210> 14772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGATT

<400> 14772
caggacaatg tattaagtag                                                   20


<210> 14773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTGGCTT

<400> 14773
ctaagactta tccagctctc                                                   20


<210> 14774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGCTT

<400> 14774
ctagaccaaa ttcaagttct                                                   20


<210> 14775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACTGATT

<400> 14775
ccttctttat tgaaaagtaa                                                   20


<210> 14776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 14776
tttatatttt aggtgtttaa                                                   20


<210> 14777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGTGTTT

<400> 14777
atgtgtgatt tttatatttt                                                   20


<210> 14778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGTGATT

<400> 14778
tagtctacct tggtaataat                                                   20


<210> 14779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GACTGATT

<400> 14779
ttctaatcca ccttaatgct                                                   20


<210> 14780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGCTT

<400> 14780
gattcattgg gattctgata                                                   20


<210> 14781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGGGATT

<400> 14781
attgtacatt tgctgattca                                                   20


<210> 14782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCTGATT

<400> 14782
ttgtaatggt attgtacatt                                                   20


<210> 14783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGTTT

<400> 14783
aagaaaatga gtagtagtat                                                   20


<210> 14784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGATT

<400> 14784
tgcgattcta aaagattaag                                                   20


<210> 14785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGATT

<400> 14785
ttgcagatga ctgcgattct                                                   20


<210> 14786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGCGATT

<400> 14786
gcatctatat ttgcagatga                                                   20


<210> 14787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCAGCTT

<400> 14787
ttttggcagc tgggggaatg                                                   20


<210> 14788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGGGATT

<400> 14788
ctgccacgat aaggcccaaa                                                   20


<210> 14789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGAGATT

<400> 14789
ttgaactgtt aaaattgcaa                                                   20


<210> 14790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGTTT

<400> 14790
gaaatctgag atttactgag                                                   20


<210> 14791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGAGATT

<400> 14791
accaatcctg agagagaaat                                                   20


<210> 14792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACGGGATT

<400> 14792
tatgctaact ttcattaatc                                                   20


<210> 14793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGGGATT

<400> 14793
aagtcagagt tgtagatagg                                                   20


<210> 14794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGAGTTT

<400> 14794
ttgaggaggt aggggaaata                                                   20


<210> 14795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGAGGATT

<400> 14795
aggacttcaa cataactttt                                                   20


<210> 14796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTGGATT

<400> 14796
cttataagga ccccagttat                                                   20


<210> 14797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGTAGTTT

<400> 14797
aatctctggc ccggtactca                                                   20


<210> 14798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCAGCTT

<400> 14798
tggaggttgt tggcaatcct                                                   20


<210> 14799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCTGCTT

<400> 14799
ctctagtaag tatcctgcct                                                   20


<210> 14800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCATGATT

<400> 14800
aaatcaaggt ctgagcaagg                                                   20


<210> 14801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTGGCTT

<400> 14801
gtaacaaatt agcaaaactc                                                   20


<210> 14802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTAGTTT

<400> 14802
gtgagctgat ccaaggatgt                                                   20


<210> 14803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGATT

<400> 14803
agggctcagg gtctagatat                                                   20


<210> 14804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCGGGATT

<400> 14804
acagctgcaa caatttaata                                                   20


<210> 14805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGCTT

<400> 14805
cttttttacc actggcagtg                                                   20


<210> 14806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAGGCTT

<400> 14806
aaacattaac aacacactac                                                   20


<210> 14807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACTGTTT

<400> 14807
catgagaata atactctttt                                                   20


<210> 14808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACGGTTT

<400> 14808
caaagagatg agttaaaaca                                                   20


<210> 14809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GACAGATT

<400> 14809
ctagtataag ttttcaggtt                                                   20


<210> 14810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGTTT

<400> 14810
attttcagtg ctctcctagt                                                   20


<210> 14811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGAGTTT

<400> 14811
ctagcatcct ggtttctcaa                                                   20


<210> 14812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTGGTTT

<400> 14812
tctcttttat gacctagcat                                                   20


<210> 14813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTTGTTT

<400> 14813
atgggtatat ttcccctttt                                                   20


<210> 14814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGCTT

<400> 14814
ggctatgggt atatttcccc                                                   20


<210> 14815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAGGTTT

<400> 14815
aatccctagc ttacttggat                                                   20


<210> 14816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTGGATT

<400> 14816
ccaacttaat ccctagctta                                                   20


<210> 14817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTAGCTT

<400> 14817
taaatgatgc caacttaatc                                                   20


<210> 14818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAAGTTT

<400> 14818
ttgtatattt caaaatagct                                                   20


<210> 14819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAAGATT

<400> 14819
ttggaggagc gaggtgtggg                                                   20


<210> 14820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGAGGCTT

<400> 14820
atagtggtta tcggaggatg                                                   20


<210> 14821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGTTT

<400> 14821
acatagaata ctgtactcct                                                   20


<210> 14822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACTGATT

<400> 14822
gagaaaaggg aatccttaca                                                   20


<210> 14823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGTTT

<400> 14823
atcaaaaaat caaaagatat                                                   20


<210> 14824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGCTT

<400> 14824
aattggatta tattaaacta                                                   20


<210> 14825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTGGATT

<400> 14825
acaaaagcaa atatagacaa                                                   20


<210> 14826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAGGATT

<400> 14826
cttcatgatg ttgttctagg                                                   20


<210> 14827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAAGCTT

<400> 14827
gagaagaaaa aaaacagggg                                                   20


<210> 14828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGAGTTT

<400> 14828
atctacacat atacagtcaa                                                   20


<210> 14829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATGGCTT

<400> 14829
ggaacaaaaa gaacaaagct                                                   20


<210> 14830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAGGTTT

<400> 14830
catattaccc aaagcaatct                                                   20


<210> 14831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATGGATT

<400> 14831
agggaaagat attccatgtt                                                   20


<210> 14832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTAGATT

<400> 14832
atgaccccat gaaaaaaagt                                                   20


<210> 14833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGTTT

<400> 14833
aaagaaggaa gtcaaattct                                                   20


<210> 14834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAAGCTT

<400> 14834
atactaacca gggaagagct                                                   20


<210> 14835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGTTT

<400> 14835
aaatcgtccc agggatgcaa                                                   20


<210> 14836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGATT

<400> 14836
tcaaatccaa cagcctatca                                                   20


<210> 14837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATGGCTT

<400> 14837
caaagaaaag tccaggacca                                                   20


<210> 14838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAAGATT

<400> 14838
aaacagacca ataatgagta                                                   20


<210> 14839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAACGTTT

<400> 14839
tgcaacttca gaatcattaa                                                   20


<210> 14840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGTTT

<400> 14840
gttctggatc atatcctttg                                                   20


<210> 14841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGTGCTT

<400> 14841
agagatagcg tgatgaagat                                                   20


<210> 14842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACAGATT

<400> 14842
cactgtaagt agctattggt                                                   20


<210> 14843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGTGCTT

<400> 14843
attattataa gtatggaatt                                                   20


<210> 14844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGCTT

<400> 14844
attctcataa ataattagac                                                   20


<210> 14845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGATT

<400> 14845
aatagattgt aataaagatt                                                   20


<210> 14846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGATT

<400> 14846
atgtgtaaaa tagattgtaa                                                   20


<210> 14847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGATT

<400> 14847
ttcagtttat ttatgtgtaa                                                   20


<210> 14848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGTTT

<400> 14848
caatttacaa aaacattttt                                                   20


<210> 14849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTAGCTT

<400> 14849
atagaatatt tgcctcaaat                                                   20


<210> 14850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGTTT

<400> 14850
tgcctttgaa atagtgatgg                                                   20


<210> 14851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 14851
attctgtcat ttttgttttg                                                   20


<210> 14852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 14852
tttaaattct gtcatttttg                                                   20


<210> 14853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 14853
tccagtttaa attctgtcat                                                   20


<210> 14854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGTTT

<400> 14854
cctcttcaga ttaaaatgtt                                                   20


<210> 14855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 14855
tttccagcct cttcagatta                                                   20


<210> 14856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGATT

<400> 14856
aggtctttct ttccagcctc                                                   20


<210> 14857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 14857
aggttcaaga tctagaggaa                                                   20


<210> 14858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAAGTTT

<400> 14858
gacttctaat tatgaacttt                                                   20


<210> 14859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATCGATT

<400> 14859
ttaaaaaaag tgtttgttgt                                                   20


<210> 14860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGTTT

<400> 14860
ttagcaagcc attttaaaaa                                                   20


<210> 14861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGTGTTT

<400> 14861
tatttttaag tcatgtagca                                                   20


<210> 14862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGAGTTT

<400> 14862
gtatgcacaa ttaaatatac                                                   20


<210> 14863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGATT

<400> 14863
tgatgttaat attctaatat                                                   20


<210> 14864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGATT

<400> 14864
tatttgtatt ttataactga                                                   20


<210> 14865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGTGATT

<400> 14865
ggttagctat cttttataac                                                   20


<210> 14866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTAGGCTT

<400> 14866
gcagagccat gtcaagagtc                                                   20


<210> 14867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGATT

<400> 14867
aaagcagact cattaaaagg                                                   20


<210> 14868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTGGATT

<400> 14868
cagttgctct cagaataaaa                                                   20


<210> 14869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAAGATT

<400> 14869
taactctgtc acccatttaa                                                   20


<210> 14870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTAGGTTT

<400> 14870
gccttttaag gagcaggcat                                                   20


<210> 14871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCAGATT

<400> 14871
tttcagctta aagttagaaa                                                   20


<210> 14872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGCTT

<400> 14872
aattttaaaa ccgtgttcat                                                   20


<210> 14873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 14873
atcactgaca caatgtaaat                                                   20


<210> 14874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGATT

<400> 14874
tatgtacact ttaaattatc                                                   20


<210> 14875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGTTT

<400> 14875
ttcctttata taaaatggca                                                   20


<210> 14876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTAGTTT

<400> 14876
tccctcgata tctatgggcg                                                   20


<210> 14877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGTTT

<400> 14877
ttaaataaat aaatcatgat                                                   20


<210> 14878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGATT

<400> 14878
ctatatttaa ttgagtgaat                                                   20


<210> 14879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGATT

<400> 14879
cataagatta aattaaatac                                                   20


<210> 14880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGATT

<400> 14880
gtctcaaaaa aaatcaatac                                                   20


<210> 14881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGCTT

<400> 14881
ccaagatcgc accgctgcac                                                   20


<210> 14882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACGAGATT

<400> 14882
atttatagtg gacttggaaa                                                   20


<210> 14883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 14883
ggcatcattt aaaaataatc                                                   20


<210> 14884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATTGCTT

<400> 14884
attacaaatt acttttatga                                                   20


<210> 14885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGAGATT

<400> 14885
ccgtattaca aattactttt                                                   20


<210> 14886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGAGTTT

<400> 14886
ctagtgagtc aaggtatgta                                                   20


<210> 14887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTGGATT

<400> 14887
caaacaattt tatacttctt                                                   20


<210> 14888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 14888
ttaacacgtt aatacatgta                                                   20


<210> 14889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGGGATT

<400> 14889
aaacactctc cacactttgc                                                   20


<210> 14890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGCTT

<400> 14890
ggtcataaac actctccaca                                                   20


<210> 14891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATAGATT

<400> 14891
tctatctcct agtgctcacc                                                   20


<210> 14892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACCAGCTT

<400> 14892
gccttcacac tatggcccta                                                   20


<210> 14893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGAGATT

<400> 14893
tcaaactttt tccccagttg                                                   20


<210> 14894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTATGTTT

<400> 14894
tttgtagaga caaggtttca                                                   20


<210> 14895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAGGTTT

<400> 14895
tttaaaaaag tttgtagaga                                                   20


<210> 14896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGTTT

<400> 14896
cacccagcta atttttttaa                                                   20


<210> 14897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATAGCTT

<400> 14897
ctggagtaca gtggtgctat                                                   20


<210> 14898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCAGATT

<400> 14898
tatttgatta ttttcgctca                                                   20


<210> 14899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGATT

<400> 14899
gcatttactc tagtttactt                                                   20


<210> 14900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTAGTTT

<400> 14900
tgcttccatt ttgcatttac                                                   20


<210> 14901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCTGCTT

<400> 14901
agcagagtct caactgatgc                                                   20


<210> 14902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCCTGTTT

<400> 14902
acacagtctc cctccacagt                                                   20


<210> 14903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCATGTTT

<400> 14903
gagccttccc atgcttcatc                                                   20


<210> 14904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCATGCTT

<400> 14904
aaaggtatct ttgagccttc                                                   20


<210> 14905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGATT

<400> 14905
ttttcttact agttcttaat                                                   20


<210> 14906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGTTT

<400> 14906
cttcctgaag attcatctgg                                                   20


<210> 14907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGATT

<400> 14907
gactttacac aacagcttcc                                                   20


<210> 14908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACAGCTT

<400> 14908
ttttgtgcgt gactttacac                                                   20


<210> 14909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATAGTTT

<400> 14909
taacattgca tgtagtgatg                                                   20


<210> 14910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGTTT

<400> 14910
gtaagaatgc ttcatatact                                                   20


<210> 14911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGCTT

<400> 14911
tgaatacagc aaagtggtaa                                                   20


<210> 14912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGTGATT

<400> 14912
atgaatgctg aggaacttag                                                   20


<210> 14913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCCGATT

<400> 14913
gtgccaattg cacctgggga                                                   20


<210> 14914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTGGTTT

<400> 14914
tcaaggaaaa agataaaatc                                                   20


<210> 14915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAAGATT

<400> 14915
aaaagcattt tccaaaaagc                                                   20


<210> 14916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGATT

<400> 14916
agaccctgat gcaaacaacc                                                   20


<210> 14917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTGGTTT

<400> 14917
aaggtgcaga aatcttcgtt                                                   20


<210> 14918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTTGATT

<400> 14918
ttttgggttc ataaaagaga                                                   20


<210> 14919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGAGTTT

<400> 14919
taatgataga tgaatgctag                                                   20


<210> 14920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACCTGTTT

<400> 14920
agtcacaatt gttttgttct                                                   20


<210> 14921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGTTT

<400> 14921
gcacaataga aaatagtcac                                                   20


<210> 14922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCACGCTT

<400> 14922
tcacattaag cagtattcta                                                   20


<210> 14923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGCTT

<400> 14923
ttcaaggggc aggtcctttt                                                   20


<210> 14924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGCTT

<400> 14924
taattaactc agaaataaaa                                                   20


<210> 14925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACATGTTT

<400> 14925
ttaaatataa tttacaattt                                                   20


<210> 14926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGTTT

<400> 14926
tttttgtttc ctggataaaa                                                   20


<210> 14927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 14927
aatgccaatt caatttcctt                                                   20


<210> 14928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGATT

<400> 14928
cgatttttaa aacatgaggt                                                   20


<210> 14929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTCGATT

<400> 14929
ttctcttcag ttaggtctta                                                   20


<210> 14930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGTTT

<400> 14930
ctttacttac atctcagaga                                                   20


<210> 14931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTATGATT

<400> 14931
gcaattatca aaattgttca                                                   20


<210> 14932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGGGATT

<400> 14932
tgacaactat taaaccattt                                                   20


<210> 14933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACAGATT

<400> 14933
ttaaaatggt ttaacgcttg                                                   20


<210> 14934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAACGCTT

<400> 14934
tgcaccctgt taaaatggtt                                                   20


<210> 14935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATGGTTT

<400> 14935
gagccactgc accctgttaa                                                   20


<210> 14936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGATT

<400> 14936
gttatagaaa tattagagac                                                   20


<210> 14937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGATT

<400> 14937
gatgatacaa atggacttta                                                   20


<210> 14938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGTTT

<400> 14938
cattttatta atatttcttc                                                   20


<210> 14939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGTTT

<400> 14939
ttaggaaaac atttggaaaa                                                   20


<210> 14940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAGGTTT

<400> 14940
aattgaaatg gttaaggacc                                                   20


<210> 14941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTGGCTT

<400> 14941
acattagagt tatatgctaa                                                   20


<210> 14942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGTGTTT

<400> 14942
aacagagggg atatattggt                                                   20


<210> 14943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGATT

<400> 14943
tgttttcctt tgaaaggcaa                                                   20


<210> 14944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGTTT

<400> 14944
catggacact ggtgtgagag                                                   20


<210> 14945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGAGGTTT

<400> 14945
gttctagatt gagacttaag                                                   20


<210> 14946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTAGATT

<400> 14946
ctgacactta aagaaagagt                                                   20


<210> 14947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGCTT

<400> 14947
tctaccaata aggttaaata                                                   20


<210> 14948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGCTT

<400> 14948
tggtctaatc cttgttttta                                                   20


<210> 14949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTTGTTT

<400> 14949
ccaattaccc atggtctaat                                                   20


<210> 14950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGTTT

<400> 14950
gtattgttta gataggaagg                                                   20


<210> 14951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGTTT

<400> 14951
tgaaaagaaa ggtatttagg                                                   20


<210> 14952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 14952
ccaataatca caaataattt                                                   20


<210> 14953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAGGTTT

<400> 14953
tttttgtatt tttagtagag                                                   20


<210> 14954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGAGATT

<400> 14954
tgcctcagcc tcctgagtag                                                   20


<210> 14955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTCGCTT

<400> 14955
tttttttttt tgagatggaa                                                   20


<210> 14956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGCTT

<400> 14956
ttataagctc ctatagcagg                                                   20


<210> 14957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCAGGATT

<400> 14957
tgtatttata agctcctata                                                   20


<210> 14958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCTGTTT

<400> 14958
cattctcttt gtttcttctt                                                   20


<210> 14959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGTTT

<400> 14959
tggaatgaaa tgcacattct                                                   20


<210> 14960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTAGTTT

<400> 14960
ttgtagtaat aaataagctt                                                   20


<210> 14961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGCTT

<400> 14961
ccctcaagtt gtagtaataa                                                   20


<210> 14962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTGGATT

<400> 14962
actgcacaaa aaatatacat                                                   20


<210> 14963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTAGATT

<400> 14963
ggcatttatg cagcacaaat                                                   20


<210> 14964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAGGATT

<400> 14964
tccttgtaac caccataaaa                                                   20


<210> 14965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCAGCTT

<400> 14965
acgttgactt gtcacagttg                                                   20


<210> 14966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAAGCTT

<400> 14966
atactgatta gtgaaaactt                                                   20


<210> 14967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACTGATT

<400> 14967
tttatttttt ttcttcctta                                                   20


<210> 14968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTGGCTT

<400> 14968
actttttgaa ttagtgtttt                                                   20


<210> 14969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGTGTTT

<400> 14969
aatctgccta ctttttgaat                                                   20


<210> 14970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGTTT

<400> 14970
tatcatttgg ccctttacga                                                   20


<210> 14971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GACTGCTT

<400> 14971
ttcatttacg tatcttctat                                                   20


<210> 14972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGATT

<400> 14972
tgtgtggccc tgggagctaa                                                   20


<210> 14973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGTTT

<400> 14973
ctgcctattc attttaaggc                                                   20


<210> 14974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTAGTTT

<400> 14974
gaaagagaac gaaattttgt                                                   20


<210> 14975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGTTT

<400> 14975
gctggtcaag ctatgtgcct                                                   20


<210> 14976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCTGATT

<400> 14976
gaacgacttc ttccactcct                                                   20


<210> 14977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCTGATT

<400> 14977
atcctggcca acattgaaca                                                   20


<210> 14978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGCTT

<400> 14978
tgattaacat taaactttat                                                   20


<210> 14979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGTGATT

<400> 14979
aaacattgaa aagattttca                                                   20


<210> 14980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGATT

<400> 14980
aatcaagatt ggaaacattg                                                   20


<210> 14981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAAGATT

<400> 14981
ctttaccctt tgaacaaaaa                                                   20


<210> 14982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCTGCTT

<400> 14982
acaatattat aggacttaaa                                                   20


<210> 14983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATAGTTT

<400> 14983
gcaatcctga actaaaagta                                                   20


<210> 14984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAGGTTT

<400> 14984
aaatatcaca aattatgata                                                   20


<210> 14985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTAGATT

<400> 14985
aaagcacatt cctctaatat                                                   20


<210> 14986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGATT

<400> 14986
gcttgtggct tacagaattt                                                   20


<210> 14987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGCTT

<400> 14987
ttatttcaga gtaagaagct                                                   20


<210> 14988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAAGCTT

<400> 14988
caataattta tttcagagta                                                   20


<210> 14989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCAAGATT

<400> 14989
ttgggaattt gaatcaaaag                                                   20


<210> 14990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGTTT

<400> 14990
ctataataaa ggggtatttc                                                   20


<210> 14991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAGGATT

<400> 14991
agctctttct agcagatgtg                                                   20


<210> 14992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAAGTTT

<400> 14992
ttgacagcct tattgtgact                                                   20


<210> 14993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACTGATT

<400> 14993
tgcagctgaa atggtattaa                                                   20


<210> 14994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCTGTTT

<400> 14994
ttattatcat tgtgttgatt                                                   20


<210> 14995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGATT

<400> 14995
aacagtgatt attatcattg                                                   20


<210> 14996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGTGATT

<400> 14996
cacagtaaat gctaagcaaa                                                   20


<210> 14997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGAGCTT

<400> 14997
atgagcactg acaggacagt                                                   20


<210> 14998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 14998
tagtgactgt gtcaattacc                                                   20


<210> 14999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGTTT

<400> 14999
ctcaaaattt cagtatcaac                                                   20


<210> 15000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAAGCTT

<400> 15000
tttgcaatgc acttttgtgt                                                   20


<210> 15001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGATT

<400> 15001
ccttgagtca aagtgtaccc                                                   20


<210> 15002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCAGATT

<400> 15002
ttcccttaga atcttctttg                                                   20


<210> 15003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGATT

<400> 15003
ctgcatccct gtgaactcag                                                   20


<210> 15004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTAGTTT

<400> 15004
tttggaaaaa ggcaggaata                                                   20


<210> 15005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGTTT

<400> 15005
aaattgtcta caaatattcc                                                   20


<210> 15006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGCTT

<400> 15006
tcaatgtcta tataagataa                                                   20


<210> 15007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCAGCTT

<400> 15007
catttttagg gccagagaat                                                   20


<210> 15008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCCAGTTT

<400> 15008
taactcaggg taaacaaaat                                                   20


<210> 15009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAAGCTT

<400> 15009
aacttcaaag acttaatgaa                                                   20


<210> 15010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGCTT

<400> 15010
tcttgggagg attaaatgct                                                   20


<210> 15011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGCTT

<400> 15011
atcatattct tgggaggatt                                                   20


<210> 15012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGAGGATT

<400> 15012
tttcatttat catattcttg                                                   20


<210> 15013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCTGATT

<400> 15013
cccaaagtcc tgggtttgaa                                                   20


<210> 15014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGTTT

<400> 15014
gtcctcagag tcccaaagtc                                                   20


<210> 15015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGTTT

<400> 15015
gctttgacat aatagtagtg                                                   20


<210> 15016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGCTT

<400> 15016
tttcagaaaa cctatggatg                                                   20


<210> 15017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCTGCTT

<400> 15017
tcacaccttc ctaattacat                                                   20


<210> 15018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGATT

<400> 15018
gttaccatct tgggagttga                                                   20


<210> 15019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAAGTTT

<400> 15019
atatgaatgg atgtgtagag                                                   20


<210> 15020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATAGTTT

<400> 15020
cttattgtgt gttatgtact                                                   20


<210> 15021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATAGTTT

<400> 15021
gatcttgcaa ttaccatttg                                                   20


<210> 15022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACAGATT

<400> 15022
aaaaatgtcc accttggtgg                                                   20


<210> 15023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCTGCTT

<400> 15023
caaatggctg actccatgtt                                                   20


<210> 15024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GACTGATT

<400> 15024
gtttcaatat tagaatgcct                                                   20


<210> 15025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTTGTTT

<400> 15025
ttcaaaatct aaactataaa                                                   20


<210> 15026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTATGCTT

<400> 15026
taatagactt acataagagg                                                   20


<210> 15027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGCTT

<400> 15027
tttcacttcc ttaccctctc                                                   20


<210> 15028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGCTT

<400> 15028
tctctgaaag atgcccacat                                                   20


<210> 15029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCTGTTT

<400> 15029
ctgttaagga aacatagttc                                                   20


<210> 15030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGTTT

<400> 15030
cacctgtgaa ctattacagc                                                   20


<210> 15031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATTGTTT

<400> 15031
ttctagttgc ttggttctag                                                   20


<210> 15032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTAGGATT

<400> 15032
ttatttctag ttgcttggtt                                                   20


<210> 15033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTTGCTT

<400> 15033
gtcctccata aattatttct                                                   20


<210> 15034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTGGCTT

<400> 15034
gtgacaactt tacaaactgt                                                   20


<210> 15035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACGTGATT

<400> 15035
aacaaggtta acccagagct                                                   20


<210> 15036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGATT

<400> 15036
tgatctgacc tttcaaagat                                                   20


<210> 15037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGCTT

<400> 15037
atactgatgg aattgttttt                                                   20


<210> 15038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGTTT

<400> 15038
taaccaatgg atactgatgg                                                   20


<210> 15039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATGGTTT

<400> 15039
gaagaattca gagaccataa                                                   20


<210> 15040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACAGATT

<400> 15040
gtaataatct tcttttactg                                                   20


<210> 15041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGATT

<400> 15041
gattctgttc ttaagacatt                                                   20


<210> 15042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAGGATT

<400> 15042
tatcttatac ctacaattta                                                   20


<210> 15043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCAAGATT

<400> 15043
tactcactac agctatataa                                                   20


<210> 15044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTATGATT

<400> 15044
acaagaatat gaagcaagca                                                   20


<210> 15045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTAGCTT

<400> 15045
gatgatataa caaaaaagca                                                   20


<210> 15046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACTGTTT

<400> 15046
acacagcact acagcacttt                                                   20


<210> 15047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGAGATT

<400> 15047
cagaaattta tcagagaata                                                   20


<210> 15048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGAGCTT

<400> 15048
cagtaagaga caaccattac                                                   20


<210> 15049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGCTT

<400> 15049
gagaggtcac ctctttcaga                                                   20


<210> 15050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGTTT

<400> 15050
tacacttgtt atgcatgagt                                                   20


<210> 15051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCAAGTTT

<400> 15051
ttttaaattt gaattagttt                                                   20


<210> 15052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTAGTTT

<400> 15052
acatagtgtt ttaaatttga                                                   20


<210> 15053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGTGTTT

<400> 15053
tggcctgcat ggaaccaaca                                                   20


<210> 15054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTTGTTT

<400> 15054
tgatagatct agagttgtat                                                   20


<210> 15055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGTTT

<400> 15055
acatatctat gcctgtatgt                                                   20


<210> 15056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTGGTTT

<400> 15056
acagactata gcacagaaaa                                                   20


<210> 15057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGTTT

<400> 15057
atttgtttaa tctgacaaat                                                   20


<210> 15058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 15058
acatgtctac atggaaaata                                                   20


<210> 15059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATGGTTT

<400> 15059
cataaaattg tggcacaata                                                   20


<210> 15060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGTTT

<400> 15060
ttaatgaagt ttcttcattt                                                   20


<210> 15061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGTTT

<400> 15061
agattatttc atatttttaa                                                   20


<210> 15062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGAGATT

<400> 15062
tatataattt atatcagatt                                                   20


<210> 15063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCAGATT

<400> 15063
taaaatacta tataatttat                                                   20


<210> 15064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 15064
ggaatcaaac tttgcttgca                                                   20


<210> 15065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGCTT

<400> 15065
taaatttctg tggaatcaaa                                                   20


<210> 15066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACAGCTT

<400> 15066
tgacctctat gtgtgcatga                                                   20


<210> 15067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGCTT

<400> 15067
atttcaattt gaataaatgc                                                   20


<210> 15068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACATGCTT

<400> 15068
ataagcttca aacatatgct                                                   20


<210> 15069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGCTT

<400> 15069
caagggcttt gactaaccca                                                   20


<210> 15070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGGGCTT

<400> 15070
gctgcattac caatatcagc                                                   20


<210> 15071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGAGTTT

<400> 15071
agtgagatct ttctcattcc                                                   20


<210> 15072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAGGCTT

<400> 15072
ggttagagaa aggtgtctga                                                   20


<210> 15073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCTGATT

<400> 15073
ctaagtggtt agagaaaggt                                                   20


<210> 15074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACTGTTT

<400> 15074
cctccatata aatgaaacat                                                   20


<210> 15075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTAGGCTT

<400> 15075
tgctatctct ccaatgtgca                                                   20


<210> 15076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCTGTTT

<400> 15076
cctaagttga aacggaggct                                                   20


<210> 15077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCTGTTT

<400> 15077
atgagatgat acattattat                                                   20


<210> 15078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACAGCTT

<400> 15078
tactgctatc tttttcaggt                                                   20


<210> 15079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGATT

<400> 15079
atcccatttc tatgaagaaa                                                   20


<210> 15080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGATT

<400> 15080
ttgtctatta attttataat                                                   20


<210> 15081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGATT

<400> 15081
ctttttctat aggaacacac                                                   20


<210> 15082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGACGTTT

<400> 15082
aacttctgat gacagcgtaa                                                   20


<210> 15083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GACAGCTT

<400> 15083
agccctcatg ctccccaatg                                                   20


<210> 15084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACTGTTT

<400> 15084
caatgagagc agaaggggct                                                   20


<210> 15085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGTTT

<400> 15085
gaagcagcag aacaagtctt                                                   20


<210> 15086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTTGTTT

<400> 15086
accactcagc attcgtggct                                                   20


<210> 15087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCACGTTT

<400> 15087
atcagtaggt gcttcagcaa                                                   20


<210> 15088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGTGCTT

<400> 15088
tgaagtgtac ttctatcagt                                                   20


<210> 15089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTATGTTT

<400> 15089
ctgaattgct tcgtttttaa                                                   20


<210> 15090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTCGTTT

<400> 15090
gttttcttct cactgaattg                                                   20


<210> 15091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGCTT

<400> 15091
aagaagtttt cttctcactg                                                   20


<210> 15092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAAGTTT

<400> 15092
tgtttcatcc cttaagtgga                                                   20


<210> 15093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGTTT

<400> 15093
ctgaaaggat gaattctaca                                                   20


<210> 15094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGGGATT

<400> 15094
tccaattttt ttgtgaagcc                                                   20


<210> 15095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCATGATT

<400> 15095
tcaatgcaaa gaaccataca                                                   20


<210> 15096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTGGATT

<400> 15096
actgagctct tagtatgtaa                                                   20


<210> 15097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGATT

<400> 15097
ctattgaact agatccttcc                                                   20


<210> 15098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTGGTTT

<400> 15098
atatgacagg agcagtccaa                                                   20


<210> 15099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAAGATT

<400> 15099
aaaaatctag ttaaaaatct                                                   20


<210> 15100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCCTGTTT

<400> 15100
ttctgttttc cttaggtctt                                                   20


<210> 15101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGTTT

<400> 15101
tccccaagat gaaccattgc                                                   20


<210> 15102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGCTT

<400> 15102
cacaaatccc caagatgaac                                                   20


<210> 15103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCCTGCTT

<400> 15103
aaccttcatc tctcaggcct                                                   20


<210> 15104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGTTT

<400> 15104
gtagtgccat agtctgttaa                                                   20


<210> 15105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTAGTTT

<400> 15105
tggttaaaaa ctaatcttag                                                   20


<210> 15106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGCTT

<400> 15106
tgtatttagt ctgtgttttg                                                   20


<210> 15107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGTTT

<400> 15107
cttttatatt tgtatttagt                                                   20


<210> 15108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGTTT

<400> 15108
caatcatttt tgaaagacct                                                   20


<210> 15109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAGGTTT

<400> 15109
gcatttatgg aaagatgtac                                                   20


<210> 15110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTATGATT

<400> 15110
gatagtgagt gatttcattg                                                   20


<210> 15111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGTGATT

<400> 15111
agaactcggg agaggatagt                                                   20


<210> 15112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGTTT

<400> 15112
cagaggacag catcagaaga                                                   20


<210> 15113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTAGGATT

<400> 15113
atgtcctgtc ctagggtttc                                                   20


<210> 15114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGGGTTT

<400> 15114
aggtgaaaga tgtcctgtcc                                                   20


<210> 15115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACATGATT

<400> 15115
gatcatttca tgtttaaagg                                                   20


<210> 15116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGTTT

<400> 15116
gtgtaaagaa aacgatcatt                                                   20


<210> 15117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGAGCTT

<400> 15117
agtttaattc taaaatacaa                                                   20


<210> 15118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGTTT

<400> 15118
taagcaaatt aataacatgt                                                   20


<210> 15119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCGAGTTT

<400> 15119
tgtcttattg catggtttat                                                   20


<210> 15120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATGGTTT

<400> 15120
tcaaattgtc tgtcttattg                                                   20


<210> 15121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCCTGATT

<400> 15121
tctttattaa accatagagt                                                   20


<210> 15122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGCTT

<400> 15122
cttaccactt tcttacaata                                                   20


<210> 15123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAAGTTT

<400> 15123
gtactaccta gggaattccc                                                   20


<210> 15124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGTGTTT

<400> 15124
atgtttttac aagaattttt                                                   20


<210> 15125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCATGTTT

<400> 15125
ttcatttata tctttatttc                                                   20


<210> 15126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGTTT

<400> 15126
gggaggtaag atgacttttt                                                   20


<210> 15127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATGGATT

<400> 15127
gaaaaatctt ttagaataat                                                   20


<210> 15128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGTTT

<400> 15128
tattattttg ccatagaact                                                   20


<210> 15129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAGGTTT

<400> 15129
agttgcctta acatttgtct                                                   20


<210> 15130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAGGCTT

<400> 15130
tcttcagtgt aaatgtttga                                                   20


<210> 15131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 15131
ccagagagat tcttcagtgt                                                   20


<210> 15132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGAGATT

<400> 15132
cctccttaat cctctttcca                                                   20


<210> 15133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAAGTTT

<400> 15133
ttaggttgtc atagattctc                                                   20


<210> 15134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATAGATT

<400> 15134
gtgtggctaa tttaggttgt                                                   20


<210> 15135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAGGATT

<400> 15135
atcatgtttt gttaatgtca                                                   20


<210> 15136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGTTT

<400> 15136
ggtatgacta aaacagtgca                                                   20


<210> 15137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTGGTTT

<400> 15137
ccagagtacc aattgtatac                                                   20


<210> 15138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATGGATT

<400> 15138
atatatacac acatacacac                                                   20


<210> 15139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGATT

<400> 15139
gaggaaaaat cttttagaat                                                   20


<210> 15140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGTTT

<400> 15140
atatataaac acatggaact                                                   20


<210> 15141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTAGATT

<400> 15141
tatatgcttg gccttctcca                                                   20


<210> 15142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGCTT

<400> 15142
tacaacagag gctctgcggt                                                   20


<210> 15143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGATT

<400> 15143
gaagaagctg aggtactgtt                                                   20


<210> 15144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGTGATT

<400> 15144
ctacatgatc ttctttgtcg                                                   20


<210> 15145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCAGATT

<400> 15145
acatgagatt ataccaaact                                                   20


<210> 15146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGAGATT

<400> 15146
ctctttatat ttttgataac                                                   20


<210> 15147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 15147
gtactgaaaa tgtgtttaat                                                   20


<210> 15148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGTTT

<400> 15148
ctatattctt cgtactgaaa                                                   20


<210> 15149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCATGATT

<400> 15149
ttcagactgt aggaaaaaat                                                   20


<210> 15150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGATT

<400> 15150
cctaaaattt gaaagtgagc                                                   20


<210> 15151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGTTT

<400> 15151
gaaaaaaaaa tctctgtacc                                                   20


<210> 15152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGTTT

<400> 15152
tggtaaagac acatgcacac                                                   20


<210> 15153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGATT

<400> 15153
ccattactgg gtatataccc                                                   20


<210> 15154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGCTT

<400> 15154
gagaaaatgt ggagaaatag                                                   20


<210> 15155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGTTT

<400> 15155
ctacaaagac acatgcacac                                                   20


<210> 15156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGATT

<400> 15156
ttattaaaaa gttgagaaac                                                   20


<210> 15157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGTGATT

<400> 15157
ccatctcaag tcagtcagaa                                                   20


<210> 15158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGATT

<400> 15158
tttatgtgat ggattacatt                                                   20


<210> 15159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATGGATT

<400> 15159
gtcattggtt ctgtttatgt                                                   20


<210> 15160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGTTT

<400> 15160
catgtggttt ttgtcattgg                                                   20


<210> 15161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGTTT

<400> 15161
tgcatctatt gagataatca                                                   20


<210> 15162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATAGTTT

<400> 15162
ccatcaatac ctagtttatt                                                   20


<210> 15163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTAGTTT

<400> 15163
tgagatatgt tccatcaata                                                   20


<210> 15164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGAGTTT

<400> 15164
attcagtatg atattggcta                                                   20


<210> 15165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGCTT

<400> 15165
cagtttttaa agggaatgct                                                   20


<210> 15166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGCTT

<400> 15166
cttgtgccag tttttaaagg                                                   20


<210> 15167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCCAGTTT

<400> 15167
agagggcatc cttgtcttgt                                                   20


<210> 15168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCTGATT

<400> 15168
accctttatt tctttctctt                                                   20


<210> 15169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCGGGTTT

<400> 15169
gagttttggg gctgagatga                                                   20


<210> 15170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGTTT

<400> 15170
tgaagttgct tatcagttta                                                   20


<210> 15171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCAGTTT

<400> 15171
ataccttgct gaagttgctt                                                   20


<210> 15172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTTGCTT

<400> 15172
gtatcctgat accttgctga                                                   20


<210> 15173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGATT

<400> 15173
gaatgcctgt gatttttgca                                                   20


<210> 15174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGATT

<400> 15174
ttgttggtgt ataggaatgc                                                   20


<210> 15175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCTGCTT

<400> 15175
agtttattca tgatttggct                                                   20


<210> 15176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGATT

<400> 15176
aattgcaaat gggagtttat                                                   20


<210> 15177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGGAGTTT

<400> 15177
tctttatagc aattgcaaat                                                   20


<210> 15178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTGGCTT

<400> 15178
cctctcttgt ttccttgagt                                                   20


<210> 15179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGTTT

<400> 15179
ttccatttgt ttgtgtcctc                                                   20


<210> 15180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 15180
tgagtatgga atgtttttcc                                                   20


<210> 15181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGTTT

<400> 15181
tcttcctatc catgagtatg                                                   20


<210> 15182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGATT

<400> 15182
cagtatggcc atttacatga                                                   20


<210> 15183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTAGTTT

<400> 15183
tggtttcata tgaaatttaa                                                   20


<210> 15184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTGGTTT

<400> 15184
ctttgctata tgtgctcttt                                                   20


<210> 15185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGCTT

<400> 15185
gatgcctcca gctttgttct                                                   20


<210> 15186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGCTT

<400> 15186
aagtcaggta ggctgatgcc                                                   20


<210> 15187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGTTT

<400> 15187
tggttactgt aacctcatag                                                   20


<210> 15188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCTGTTT

<400> 15188
ctgtttgggt accactacca                                                   20


<210> 15189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCTGTTT

<400> 15189
tctattccat tggcctatat                                                   20


<210> 15190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGCTT

<400> 15190
tgtcaggttt gtcgaagatc                                                   20


<210> 15191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAGGTTT

<400> 15191
ttccacattg cttgtttttg                                                   20


<210> 15192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTTGTTT

<400> 15192
tagggaatcc tttccacatt                                                   20


<210> 15193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGCTT

<400> 15193
tatataggga atcctttcca                                                   20


<210> 15194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCCAGCTT

<400> 15194
cagttttctg catatggcta                                                   20


<210> 15195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGTTT

<400> 15195
gtgtaaggaa ggagcccagt                                                   20


<210> 15196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCCAGTTT

<400> 15196
tataaggtgt aaggaaggag                                                   20


<210> 15197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGGGTTT

<400> 15197
cttctagggt tttcatggtt                                                   20


<210> 15198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATGGTTT

<400> 15198
aggttttctt ctagggtttt                                                   20


<210> 15199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGGGTTT

<400> 15199
gtgttgccta ggttttcttc                                                   20


<210> 15200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTAGGTTT

<400> 15200
tatttcctga atggtgttgc                                                   20


<210> 15201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGCTT

<400> 15201
tcaattttgg ctttggttgc                                                   20


<210> 15202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGCTT

<400> 15202
gttatatccc atttgtcaat                                                   20


<210> 15203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGTTT

<400> 15203
cttttgctgt gcagaagctc                                                   20


<210> 15204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTAGTTT

<400> 15204
gtttgcctgt tcactctgat                                                   20


<210> 15205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGTTT

<400> 15205
gccaaatttt tctcccattc                                                   20


<210> 15206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTAGATT

<400> 15206
tattagacct ttgtcagatg                                                   20


<210> 15207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGATT

<400> 15207
ataaatttgt ttaagttact                                                   20


<210> 15208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 15208
aaatgttaat tatcttataa                                                   20


<210> 15209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGCTT

<400> 15209
actatcctaa attcacttta                                                   20


<210> 15210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCTGTTT

<400> 15210
ttttctcaga atagctgcag                                                   20


<210> 15211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGATT

<400> 15211
ttattctata gtacacataa                                                   20


<210> 15212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGATT

<400> 15212
agccaaaagg aaggagacca                                                   20


<210> 15213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCATGATT

<400> 15213
ttgctcccaa ctgtagactt                                                   20


<210> 15214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTAAGTTT

<400> 15214
taaagatgca attcatttct                                                   20


<210> 15215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCATGTTT

<400> 15215
ctctgatgtt cacctgctca                                                   20


<210> 15216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCGTGCTT

<400> 15216
gcacatggac tgttttccat                                                   20


<210> 15217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GACTGTTT

<400> 15217
tcaagctgct cctgcacatg                                                   20


<210> 15218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGTTT

<400> 15218
ttaagtacca ggacatactg                                                   20


<210> 15219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGTTT

<400> 15219
tatcttatta ccaaaattat                                                   20


<210> 15220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGAGGTTT

<400> 15220
tatgttaaga gcctgtatta                                                   20


<210> 15221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCAAGATT

<400> 15221
gccttgttta ggctaatgac                                                   20


<210> 15222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTTGTTT

<400> 15222
tttcagctgg gccttcttag                                                   20


<210> 15223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACGAGCTT

<400> 15223
gaaaccctga ttatggctac                                                   20


<210> 15224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCCTGATT

<400> 15224
tgtgtgaaaa ttggcagaaa                                                   20


<210> 15225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGCTT

<400> 15225
gtaacttttc agtaaggcta                                                   20


<210> 15226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGAGTTT

<400> 15226
gtccccctat agaagaaacc                                                   20


<210> 15227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTATGATT

<400> 15227
gatgatgatg ctaatggcag                                                   20


<210> 15228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCATGTTT

<400> 15228
aaaacgtctg ttgaaaattt                                                   20


<210> 15229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGCTT

<400> 15229
ccaagaatta tacagacaga                                                   20


<210> 15230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGCTT

<400> 15230
gtagcatcag ctgcataagc                                                   20


<210> 15231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCTGCTT

<400> 15231
atatattcaa ctgtccatct                                                   20


<210> 15232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGGGATT

<400> 15232
tgttttggcc actctaagca                                                   20


<210> 15233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGTTT

<400> 15233
gactcatagg tgactgaatg                                                   20


<210> 15234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGCTT

<400> 15234
caaattagtc tttgattcta                                                   20


<210> 15235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGATT

<400> 15235
cagtcagttt gcaaattagt                                                   20


<210> 15236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCAGTTT

<400> 15236
gagaaggaaa agaatgttca                                                   20


<210> 15237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 15237
acagattcag ggtatgtaat                                                   20


<210> 15238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACAGATT

<400> 15238
gctctccttt gtggtttcag                                                   20


<210> 15239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGTTT

<400> 15239
gatccaaaga tgctctcctt                                                   20


<210> 15240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACAGATT

<400> 15240
tttacctcct ttatcacaat                                                   20


<210> 15241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGATT

<400> 15241
atgtttattg cctagcctct                                                   20


<210> 15242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGTTT

<400> 15242
tttatttatc gtgtttattg                                                   20


<210> 15243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCGTGTTT

<400> 15243
aaaactaatg attttattta                                                   20


<210> 15244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGATT

<400> 15244
taaaggaggt ctcataaaac                                                   20


<210> 15245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTAGTTT

<400> 15245
cttctttgtc acacttaggt                                                   20


<210> 15246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGGGCTT

<400> 15246
caccaacttc atctctgcct                                                   20


<210> 15247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTGGCTT

<400> 15247
gtagccacac tggccatctt                                                   20


<210> 15248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGATGTTT

<400> 15248
gtttgtataa gtgcacccta                                                   20


<210> 15249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTAGGTTT

<400> 15249
tgtatggtag cctataccat                                                   20


<210> 15250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAGGTTT

<400> 15250
tgagtacagt agcccactct                                                   20


<210> 15251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGATT

<400> 15251
atatatataa tggtgatctc                                                   20


<210> 15252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGATGTTT

<400> 15252
cggagtattg taccacataa                                                   20


<210> 15253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGATT

<400> 15253
ggtgaaacat ggaaaatctg                                                   20


<210> 15254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGTTT

<400> 15254
gatatttaag agagatgaca                                                   20


<210> 15255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCAGATT

<400> 15255
actccaaaag tctcccaata                                                   20


<210> 15256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCATGATT

<400> 15256
ctgatttcat agtctttctt                                                   20


<210> 15257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCTGATT

<400> 15257
caacattcaa atccaagaat                                                   20


<210> 15258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATGGCTT

<400> 15258
agatgcagca gctaaggctt                                                   20


<210> 15259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAGGCTT

<400> 15259
tattttacag atgcagcagc                                                   20


<210> 15260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTGGTTT

<400> 15260
atgtgtggat cacagtatca                                                   20


<210> 15261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCTGTTT

<400> 15261
gtttaactaa ttataataac                                                   20


<210> 15262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGTTT

<400> 15262
agttttatct caaattgtat                                                   20


<210> 15263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGTTT

<400> 15263
tgatgatgtg taattcaatc                                                   20


<210> 15264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGTTT

<400> 15264
cacctcaaac tgcaaggctt                                                   20


<210> 15265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAGGCTT

<400> 15265
tacatttgca cctcaaactg                                                   20


<210> 15266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAAGCTT

<400> 15266
aggttcagga gtgttttcag                                                   20


<210> 15267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGTGTTT

<400> 15267
ccatccttcc cgaggttcag                                                   20


<210> 15268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGATGTTT

<400> 15268
catccttatt aaaatatttt                                                   20


<210> 15269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTAGTTT

<400> 15269
gttgataaat gtgaaccagc                                                   20


<210> 15270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGCTT

<400> 15270
aacctagagt gagctacctg                                                   20


<210> 15271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGTTT

<400> 15271
tagttgttta gaaattattg                                                   20


<210> 15272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTTGTTT

<400> 15272
atcttaataa tttaatgtct                                                   20


<210> 15273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCGTGATT

<400> 15273
gcgtgagcca ctgcgcccgg                                                   20


<210> 15274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGGGGTTT

<400> 15274
ttttgtattt ttagtagaga                                                   20


<210> 15275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGGGATT

<400> 15275
ttctcagtat atacctagta                                                   20


<210> 15276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAAGTTT

<400> 15276
gttgctgtaa acattcatgt                                                   20


<210> 15277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 15277
cattgtatgt atatgctata                                                   20


<210> 15278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTATGCTT

<400> 15278
atccatggta tagtatgtat                                                   20


<210> 15279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGTTT

<400> 15279
ctggcttctt acacctagca                                                   20


<210> 15280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTGGCTT

<400> 15280
ataatatatg gctttttgta                                                   20


<210> 15281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATGGCTT

<400> 15281
atacatggaa gcatataata                                                   20


<210> 15282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGATT

<400> 15282
ccctagggat ttacccactc                                                   20


<210> 15283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGGGATT

<400> 15283
actaatctac tttctgtccc                                                   20


<210> 15284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAGGTTT

<400> 15284
tgctgcattc ccttttaaaa                                                   20


<210> 15285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTAGATT

<400> 15285
aaacttcacc cagaatcttc                                                   20


<210> 15286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTAGTTT

<400> 15286
gcccagtcct gatcccctgc                                                   20


<210> 15287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCTGTTT

<400> 15287
ttcctatctc cttcatctac                                                   20


<210> 15288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAAGTTT

<400> 15288
aatatttgac atttaataga                                                   20


<210> 15289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCTGTTT

<400> 15289
aaaacaggat attctcttcc                                                   20


<210> 15290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGATT

<400> 15290
ctgctgaaaa acatacaatt                                                   20


<210> 15291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATGGATT

<400> 15291
cactgatgat aatgaatgcc                                                   20


<210> 15292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCCAGATT

<400> 15292
ccagcatgga aaagacagat                                                   20


<210> 15293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGAGTTT

<400> 15293
ataaccattc acttggttgt                                                   20


<210> 15294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGAGATT

<400> 15294
tttgagtgca aatttgatgt                                                   20


<210> 15295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGATT

<400> 15295
tgaggaagag aaaattctac                                                   20


<210> 15296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATGGTTT

<400> 15296
agatgattga gttcaaaccc                                                   20


<210> 15297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGATT

<400> 15297
aagactgcag agttatcaaa                                                   20


<210> 15298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGATGTTT

<400> 15298
aaatatatgg gtttttgtat                                                   20


<210> 15299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGGGTTT

<400> 15299
gctggcattt aaaaaaatat                                                   20


<210> 15300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGCTT

<400> 15300
aaaacatatt gtagaaacag                                                   20


<210> 15301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGAGTTT

<400> 15301
tatagaaatc agagggcctg                                                   20


<210> 15302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGAGATT

<400> 15302
ggatatataa tatagagaat                                                   20


<210> 15303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCAGTTT

<400> 15303
ggaagcattg aggatgactt                                                   20


<210> 15304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATGGATT

<400> 15304
caaagtctgt agagcttgct                                                   20


<210> 15305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGAGCTT

<400> 15305
agctcaacat acaaagtctg                                                   20


<210> 15306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGTTT

<400> 15306
tcatctaggc aagagaaaat                                                   20


<210> 15307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTTGCTT

<400> 15307
aataagaaag gtaagttgaa                                                   20


<210> 15308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACTGATT

<400> 15308
ttgctgtctg tcttgtgcac                                                   20


<210> 15309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGAGTTT

<400> 15309
ggacatttca gcccatggga                                                   20


<210> 15310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGTGGTTT

<400> 15310
aaagaatgga aaaacagcag                                                   20


<210> 15311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGGGTTT

<400> 15311
gtcctgaata aagggagggt                                                   20


<210> 15312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCTGCTT

<400> 15312
gtgagtctat gtgtgggggg                                                   20


<210> 15313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGTTT

<400> 15313
aagatagtaa gaagccataa                                                   20


<210> 15314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 15314
catctagtgg gaatgaaaaa                                                   20


<210> 15315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGAGCTT

<400> 15315
agcctcagcc cttgctttca                                                   20


<210> 15316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTTGCTT

<400> 15316
caataaatga tagcctcagc                                                   20


<210> 15317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATGGTTT

<400> 15317
atttattggt gcgtttatta                                                   20


<210> 15318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGCGTTT

<400> 15318
attcaaactt tcatttattg                                                   20


<210> 15319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGATT

<400> 15319
gaagccattt ttgactgcat                                                   20


<210> 15320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGTTT

<400> 15320
aaatcaagtc tgaattttgc                                                   20


<210> 15321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGCTT

<400> 15321
gtgtttaaat caagtctgaa                                                   20


<210> 15322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGTGTTT

<400> 15322
gaaatgtagt tttagtgaag                                                   20


<210> 15323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGTTT

<400> 15323
ttctttattt tcttctgaaa                                                   20


<210> 15324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATCGCTT

<400> 15324
tcaggaggct gaggcaggag                                                   20


<210> 15325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGCTT

<400> 15325
tttaattcat cgctttctgg                                                   20


<210> 15326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATCGCTT

<400> 15326
taatcaaatt taatttaatt                                                   20


<210> 15327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTAGATT

<400> 15327
gcaatttgtt tacatatgaa                                                   20


<210> 15328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 15328
tactaataga ttagaatgca                                                   20


<210> 15329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGATT

<400> 15329
acttgttaca agaatatact                                                   20


<210> 15330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGATT

<400> 15330
ggttggctga agctcagctg                                                   20


<210> 15331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGCTT

<400> 15331
acaaaaacag cttgattgct                                                   20


<210> 15332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATTGCTT

<400> 15332
gtgacgcaca aaaacagctt                                                   20


<210> 15333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTTGATT

<400> 15333
gggagtgacg cacaaaaaca                                                   20


<210> 15334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACAGCTT

<400> 15334
aaaagggagt gacgcacaaa                                                   20


<210> 15335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGATT

<400> 15335
ctgaaataag ataataataa                                                   20


<210> 15336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCAGCTT

<400> 15336
attttcaaca aattaaattt                                                   20


<210> 15337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATGGTTT

<400> 15337
atttctgagt ttatactgtg                                                   20


<210> 15338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGAGTTT

<400> 15338
tctgagtctt gctcctattt                                                   20


<210> 15339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAAGTTT

<400> 15339
tttaccacac ttatttaaac                                                   20


<210> 15340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGATT

<400> 15340
gagtaactta catttaatat                                                   20


<210> 15341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACATGATT

<400> 15341
ccagtttctg attgttacaa                                                   20


<210> 15342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGATT

<400> 15342
tatttaccct cttttccagt                                                   20


<210> 15343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGTTT

<400> 15343
tttttatatt taccctcttt                                                   20


<210> 15344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 15344
aaactgaaag ttttgaagta                                                   20


<210> 15345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAAGTTT

<400> 15345
gaagccttaa caagaaaact                                                   20


<210> 15346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAGGATT

<400> 15346
aggaaatgag ggaggaaagg                                                   20


<210> 15347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAAGATT

<400> 15347
aatattggat gaagatatga                                                   20


<210> 15348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGAGTTT

<400> 15348
cttaattcag aagtatcaat                                                   20


<210> 15349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCTGCTT

<400> 15349
atctgtatgc actctcagaa                                                   20


<210> 15350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAAGTTT

<400> 15350
ataggctgat ggcaagatat                                                   20


<210> 15351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATGGCTT

<400> 15351
cgagtttcat agctgttttt                                                   20


<210> 15352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCTGTTT

<400> 15352
taaccaatga cgagtttcat                                                   20


<210> 15353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACGAGTTT

<400> 15353
catccacttt gtaaccaatg                                                   20


<210> 15354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCAGCTT

<400> 15354
gtacaaagca aaatcatttg                                                   20


<210> 15355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGATT

<400> 15355
ctgtatcttg atagtattcc                                                   20


<210> 15356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGATT

<400> 15356
tatgatagat ttttatactt                                                   20


<210> 15357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATAGATT

<400> 15357
taatgtgaca tatttattat                                                   20


<210> 15358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGATT

<400> 15358
accattacat ttaacaatat                                                   20


<210> 15359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGATT

<400> 15359
gtgaatttgg gtcatgttat                                                   20


<210> 15360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGCTT

<400> 15360
gctctctttt aataatgaaa                                                   20


<210> 15361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 15361
tcatgggaaa cctgaagcat                                                   20


<210> 15362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGTGTTT

<400> 15362
cctgactgtg ttctgtctga                                                   20


<210> 15363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAAGCTT

<400> 15363
ggctttgatc cagtcagtga                                                   20


<210> 15364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGGGCTT

<400> 15364
tcaggcctga agacaattgt                                                   20


<210> 15365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAGGCTT

<400> 15365
tgtgtttttt gtttcgattc                                                   20


<210> 15366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTCGATT

<400> 15366
aggaaagctt gtgttttttg                                                   20


<210> 15367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 15367
tttctaggaa agcttgtgtt                                                   20


<210> 15368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGTTT

<400> 15368
gcatgacttt ctaggaaagc                                                   20


<210> 15369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAAGCTT

<400> 15369
tataatgcat gactttctag                                                   20


<210> 15370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGATT

<400> 15370
tgaattaggt tacttaaggt                                                   20


<210> 15371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAGGCTT

<400> 15371
tatataaaat agcaaaccca                                                   20


<210> 15372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTGGTTT

<400> 15372
cttacaaaaa ttatttttaa                                                   20


<210> 15373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGTTT

<400> 15373
gtgccattta tagagaagtg                                                   20


<210> 15374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTGGTTT

<400> 15374
tttggtgcca tttatagaga                                                   20


<210> 15375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 15375
aggtgtcact atatgctgta                                                   20


<210> 15376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGTTT

<400> 15376
agcatgggga tattgcatga                                                   20


<210> 15377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGATT

<400> 15377
ggaaaatttc aatccatttt                                                   20


<210> 15378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGCTT

<400> 15378
gtctgagggt ttgtttttcc                                                   20


<210> 15379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGTTT

<400> 15379
atcttccctc ctgtctgagg                                                   20


<210> 15380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGGGTTT

<400> 15380
tgaaatcttc cctcctgtct                                                   20


<210> 15381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGAGTTT

<400> 15381
tcattatcaa aagtcaacct                                                   20


<210> 15382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGTTT

<400> 15382
ttttaattaa atttgatttc                                                   20


<210> 15383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGATT

<400> 15383
ctttatgcaa ttttaattaa                                                   20


<210> 15384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGAGTTT

<400> 15384
cccctattac agatatgtga                                                   20


<210> 15385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTCGTTT

<400> 15385
ctatttggga gttgttcttt                                                   20


<210> 15386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGAGCTT

<400> 15386
cttcgaactt tcagagtatt                                                   20


<210> 15387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGTTT

<400> 15387
acagaatttg taaacctagg                                                   20


<210> 15388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGATT

<400> 15388
tctatctaaa ttctgaataa                                                   20


<210> 15389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 15389
aataatatat aatatctgta                                                   20


<210> 15390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTTGTTT

<400> 15390
gtccaacaat tgaaacattt                                                   20


<210> 15391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGTTT

<400> 15391
gacacttagc atactatttt                                                   20


<210> 15392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGATT

<400> 15392
tatctctatg gatttgtcta                                                   20


<210> 15393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATGGATT

<400> 15393
actcatctat gttttatctc                                                   20


<210> 15394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTATGTTT

<400> 15394
gccccttgga aaccactcat                                                   20


<210> 15395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAAGTTT

<400> 15395
catcaccact acctaattag                                                   20


<210> 15396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGTGTTT

<400> 15396
caattttaaa gtatacaatt                                                   20


<210> 15397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCCGATT

<400> 15397
agggtcttaa gattcctaat                                                   20


<210> 15398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAAGATT

<400> 15398
ctagacaata cagaagggtc                                                   20


<210> 15399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATGGATT

<400> 15399
ccaaatgtat ttatcagaaa                                                   20


<210> 15400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCAGTTT

<400> 15400
gtatacacat tatatataca                                                   20


<210> 15401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTAAGATT

<400> 15401
gctgtcactg cttactaagc                                                   20


<210> 15402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACTGCTT

<400> 15402
tatatttgta aaagagctgt                                                   20


<210> 15403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGTTT

<400> 15403
ggtttacact ttttccaagt                                                   20


<210> 15404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAGGTTT

<400> 15404
gatagtctat gcagtgccaa                                                   20


<210> 15405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGAGATT

<400> 15405
ctcagaggta tgtgacatca                                                   20


<210> 15406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCTGATT

<400> 15406
aataacagca aacctctggg                                                   20


<210> 15407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGCTT

<400> 15407
attgtttttg cgtaagtact                                                   20


<210> 15408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGTTT

<400> 15408
aactggctgg attttgtcgt                                                   20


<210> 15409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTGGATT

<400> 15409
cttcgtgacc cgtggaactg                                                   20


<210> 15410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAGGCTT

<400> 15410
cacttgtaaa aatccttgca                                                   20


<210> 15411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGTTT

<400> 15411
tctagtatcc caatggaatc                                                   20


<210> 15412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGATT

<400> 15412
taattagaga aaataagtta                                                   20


<210> 15413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGTTT

<400> 15413
tattttctgg atagacctat                                                   20


<210> 15414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGTGTTT

<400> 15414
caagtacctc tgctttctgg                                                   20


<210> 15415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCTGCTT

<400> 15415
ttcttagtta tttcaagtac                                                   20


<210> 15416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGATT

<400> 15416
aattatatgg gtgtattttt                                                   20


<210> 15417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTATGTTT

<400> 15417
cacatatttt attcttgggt                                                   20


<210> 15418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGTGTTT

<400> 15418
attagaaaaa ttagatgcta                                                   20


<210> 15419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTAGATT

<400> 15419
ctcctctatg atattaacct                                                   20


<210> 15420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTTGCTT

<400> 15420
tttaccttcc catgttatat                                                   20


<210> 15421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGCTT

<400> 15421
aatctttacc ttcccatgtt                                                   20


<210> 15422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGTTT

<400> 15422
tgggtataag tacattttaa                                                   20


<210> 15423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTTGATT

<400> 15423
ccactgtcgt ctcttttgtt                                                   20


<210> 15424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAAGATT

<400> 15424
agactgggag agtggcaata                                                   20


<210> 15425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGTTT

<400> 15425
gcaccttgaa agactctggt                                                   20


<210> 15426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTGGTTT

<400> 15426
ccttttgcac cttgaaagac                                                   20


<210> 15427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGATT

<400> 15427
gtacactcat atccttttaa                                                   20


<210> 15428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAAGATT

<400> 15428
tcctctaaga agaatatcta                                                   20


<210> 15429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGCTT

<400> 15429
caatgccaca cctgctttat                                                   20


<210> 15430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACCTGCTT

<400> 15430
atcttccgtt tcaatgccac                                                   20


<210> 15431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCCGTTT

<400> 15431
tgaacaaagg gaaaacaatc                                                   20


<210> 15432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGATT

<400> 15432
ttgatgtgaa aaattgatat                                                   20


<210> 15433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGTGTTT

<400> 15433
acattgctgg agtctgatgg                                                   20


<210> 15434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGCTT

<400> 15434
ttagagatag ctagtttcta                                                   20


<210> 15435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTAGTTT

<400> 15435
tgataaaaat attagagata                                                   20


<210> 15436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAGGTTT

<400> 15436
ccagcaagta ttaaaattct                                                   20


<210> 15437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAGGATT

<400> 15437
gaaattgaac tcagtgattg                                                   20


<210> 15438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGTGATT

<400> 15438
taaaataaag aaattgaact                                                   20


<210> 15439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATCGTTT

<400> 15439
agaatgtttg cttctattca                                                   20


<210> 15440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGCTT

<400> 15440
tacaataaca tttcaagaat                                                   20


<210> 15441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGTTT

<400> 15441
tggctacaat aacatttcaa                                                   20


<210> 15442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTTGTTT

<400> 15442
aatattttgt tgttactgct                                                   20


<210> 15443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTTGCTT

<400> 15443
atttctaagc caatgcttta                                                   20


<210> 15444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGCTT

<400> 15444
tgtctttctg atttctaagc                                                   20


<210> 15445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGATT

<400> 15445
ctgggatttg aactttgtct                                                   20


<210> 15446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGATT

<400> 15446
ccaaccggag aaaaataagg                                                   20


<210> 15447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGCTT

<400> 15447
tacctcctga atacggtgag                                                   20


<210> 15448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 15448
cctgaaaaca atagactctg                                                   20


<210> 15449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCTGATT

<400> 15449
ggacacctga aaacaataga                                                   20


<210> 15450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGATT

<400> 15450
tctactgaga tttaagacaa                                                   20


<210> 15451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGAGATT

<400> 15451
ttttttaaaa atacagtcta                                                   20


<210> 15452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGAGATT

<400> 15452
cgtggggatt acaattcaaa                                                   20


<210> 15453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGGGATT

<400> 15453
caggtccctc ccctgagacg                                                   20


<210> 15454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGATT

<400> 15454
actgggtaat ttataaagaa                                                   20


<210> 15455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGGGGATT

<400> 15455
ttttgtattt ttagtagaga                                                   20


<210> 15456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 15456
ccgccaccac acctggctaa                                                   20


<210> 15457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCGCGATT

<400> 15457
gcccaggctg gagtgccgtg                                                   20


<210> 15458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGTTT

<400> 15458
cttttcatta cctgttatga                                                   20


<210> 15459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCGGTTT

<400> 15459
tcatgttagc tcagatgacc                                                   20


<210> 15460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGATT

<400> 15460
tgccaatact atgtagtatg                                                   20


<210> 15461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGTTT

<400> 15461
tgcagaccca aaaatcactt                                                   20


<210> 15462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGTTT

<400> 15462
tagtatacat tgtttagtat                                                   20


<210> 15463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGTTT

<400> 15463
gtttagtata acatagtata                                                   20


<210> 15464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGTTT

<400> 15464
agcaattgtg aaatttagta                                                   20


<210> 15465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTGGATT

<400> 15465
gtccttcaca tcccttgtaa                                                   20


<210> 15466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTGGTTT

<400> 15466
cctcttttat ttccttgagc                                                   20


<210> 15467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 15467
tgagcatgga atgttcttcc                                                   20


<210> 15468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGATT

<400> 15468
cagtatggcc attttcacga                                                   20


<210> 15469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTAGCTT

<400> 15469
gttctgtgaa gaaagtcatt                                                   20


<210> 15470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTAGTTT

<400> 15470
tggttccata tgaactttaa                                                   20


<210> 15471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAGGATT

<400> 15471
tccagctttg ttcttttggc                                                   20


<210> 15472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGCTT

<400> 15472
gatgcctcca gctttgttct                                                   20


<210> 15473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGCTT

<400> 15473
aagtcaggta gcgtgatgcc                                                   20


<210> 15474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGTTT

<400> 15474
gggttactgt agccttgtag                                                   20


<210> 15475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCTGTTT

<400> 15475
ctgttttggt accagtacca                                                   20


<210> 15476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCTGTTT

<400> 15476
tctgttccat tgatctatat                                                   20


<210> 15477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAGGTTT

<400> 15477
ttccccattg cttgtttttc                                                   20


<210> 15478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTTGTTT

<400> 15478
tagggaatcc tttccccatt                                                   20


<210> 15479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGCTT

<400> 15479
taaataggga atcctttccc                                                   20


<210> 15480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCCAGTTT

<400> 15480
cagctttcta catatggcta                                                   20


<210> 15481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGCTT

<400> 15481
gtgtaaggaa gggatccagt                                                   20


<210> 15482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGTTT

<400> 15482
tataaggtgt aaggaaggga                                                   20


<210> 15483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGATT

<400> 15483
taagtcttta atccatcttg                                                   20


<210> 15484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGTTT

<400> 15484
ggtttttatg gttttaggtc                                                   20


<210> 15485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATGGTTT

<400> 15485
gggttttctt ctagggtttt                                                   20


<210> 15486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGGGTTT

<400> 15486
gtaatgcctg ggttttcttc                                                   20


<210> 15487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGTTT

<400> 15487
tatgtcctga atggtaatgc                                                   20


<210> 15488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGTGTTT

<400> 15488
tcttttgttg ccattgcttt                                                   20


<210> 15489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGCTT

<400> 15489
tcaattttgt cttttgttgc                                                   20


<210> 15490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGTTT

<400> 15490
attttgctgt gcagaagctc                                                   20


<210> 15491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTAGTTT

<400> 15491
ggttgcatgt tcactctgat                                                   20


<210> 15492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGATT

<400> 15492
gtaaatttgt ttgagttcat                                                   20


<210> 15493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 15493
tgtttgtttt tttcttgtaa                                                   20


<210> 15494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGTTT

<400> 15494
gcccactttt tgatggggtt                                                   20


<210> 15495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTTGTTT

<400> 15495
ctttgcccac tttttgatgg                                                   20


<210> 15496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGTTT

<400> 15496
gtgatgatga gcattttttc                                                   20


<210> 15497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGATT

<400> 15497
gagatggtat ctcattgtgg                                                   20


<210> 15498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGTTT

<400> 15498
ggtgtgagat ggtatctcat                                                   20


<210> 15499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGATT

<400> 15499
cctgttgttt cctgactttt                                                   20


<210> 15500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGTTT

<400> 15500
tccacatcct ctccagcacc                                                   20


<210> 15501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTAGTTT

<400> 15501
ctgacttcca caatggttga                                                   20


<210> 15502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCATGATT

<400> 15502
gtgcatgtgt ctttatagca                                                   20


<210> 15503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGTTT

<400> 15503
tggacatttg ggttggttcc                                                   20


<210> 15504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGATGATT

<400> 15504
ttgtgatagt ttactgagaa                                                   20


<210> 15505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATAGTTT

<400> 15505
gtttggtttt ttattcttgt                                                   20


<210> 15506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGTTT

<400> 15506
atgagtgaga atatgcggtg                                                   20


<210> 15507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGGTGTTT

<400> 15507
cacctatgag tgagaatatg                                                   20


<210> 15508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGATT

<400> 15508
atattcccct tcctgtgtcc                                                   20


<210> 15509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAAGTTT

<400> 15509
tttttttttt taattatact                                                   20


<210> 15510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGAGATT

<400> 15510
tgtataaaaa ttattttaaa                                                   20


<210> 15511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTGGCTT

<400> 15511
gacttcagtg gtcagtttct                                                   20


<210> 15512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCAGTTT

<400> 15512
agtttatttt gacttcagtg                                                   20


<210> 15513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGAGTTT

<400> 15513
cctactatgc agacaaaaag                                                   20


<210> 15514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGAGCTT

<400> 15514
tgttgcctcc cccaggacct                                                   20


<210> 15515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGTTT

<400> 15515
aaatagttaa gtctttattt                                                   20


<210> 15516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTAGTTT

<400> 15516
aatctgttta tgttgttatt                                                   20


<210> 15517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCTGTTT

<400> 15517
ttttgtagtt gaaactaaaa                                                   20


<210> 15518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGTTT

<400> 15518
cagaggattt agaatattac                                                   20


<210> 15519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAGGATT

<400> 15519
aacattgttg aagtgacagc                                                   20


<210> 15520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTGGTTT

<400> 15520
tctgattgat aagcaaagaa                                                   20


<210> 15521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGATT

<400> 15521
ttgaatggat gaggagttgc                                                   20


<210> 15522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTTGCTT

<400> 15522
ggtaacttga atggatgagg                                                   20


<210> 15523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAGGTTT

<400> 15523
aactctcatg gatgactatg                                                   20


<210> 15524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTTGATT

<400> 15524
attaatagga aattggaatg                                                   20


<210> 15525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGATT

<400> 15525
tctagatgtt attagaacat                                                   20


<210> 15526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGATT

<400> 15526
gtaaattgaa aatcttctgg                                                   20


<210> 15527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGTGATT

<400> 15527
aagactatag ctgccataga                                                   20


<210> 15528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGATT

<400> 15528
ttatagctca ggaaaaaaaa                                                   20


<210> 15529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCTGTTT

<400> 15529
caaagcctgg atgacagcac                                                   20


<210> 15530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAAGCTT

<400> 15530
gagaagtcaa tgtctggctt                                                   20


<210> 15531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTGGCTT

<400> 15531
ctagaaagga gaagtcaatg                                                   20


<210> 15532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACAGATT

<400> 15532
taagagtggt tacattaaac                                                   20


<210> 15533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGAGATT

<400> 15533
aagctggcag acggtacccc                                                   20


<210> 15534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGTTT

<400> 15534
aggtgaagaa gctggaaaaa                                                   20


<210> 15535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAAGTTT

<400> 15535
agccttattg caaatataga                                                   20


<210> 15536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAAGCTT

<400> 15536
aaatcagaag ctagaaatga                                                   20


<210> 15537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGATT

<400> 15537
cactttaaat cagaagctag                                                   20


<210> 15538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAGGCTT

<400> 15538
ccctatctct ctccctttcc                                                   20


<210> 15539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGTTT

<400> 15539
caatcattaa atgtgacgtg                                                   20


<210> 15540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGTTT

<400> 15540
atctttgttg ttactgtggt                                                   20


<210> 15541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAGGTTT

<400> 15541
tactgcattc tttacaagtt                                                   20


<210> 15542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGGGCTT

<400> 15542
tacaggcata cttcatttta                                                   20


<210> 15543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGTTT

<400> 15543
ttaaaaacct ttatcctaac                                                   20


<210> 15544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGTTT

<400> 15544
gtaaacgttc ttgtgtggac                                                   20


<210> 15545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGTTT

<400> 15545
ttcattggtg agtaatgagg                                                   20


<210> 15546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGTGTTT

<400> 15546
tttattgcta aatactaatt                                                   20


<210> 15547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 15547
gtaacatgta cctatacttc                                                   20


<210> 15548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGGGGTTT

<400> 15548
tttggctctg tgttctttca                                                   20


<210> 15549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGGGATT

<400> 15549
aatactctac attttgtttc                                                   20


<210> 15550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 15550
ctgacaaaaa atactctaca                                                   20


<210> 15551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGTTT

<400> 15551
gtatgcaaca atcatcatta                                                   20


<210> 15552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTGGTTT

<400> 15552
cattttaaag tgtatcactc                                                   20


<210> 15553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTAGTTT

<400> 15553
aattcttaat gcatattcat                                                   20


<210> 15554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAGGATT

<400> 15554
gaggacaatt ttcacatatt                                                   20


<210> 15555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 15555
tgctttgatt tgattcattg                                                   20


<210> 15556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGATT

<400> 15556
gcaactgctt tgatttgatt                                                   20


<210> 15557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGATT

<400> 15557
cacaagtggc aactgctttg                                                   20


<210> 15558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGATT

<400> 15558
caaagcacaa gtggcaactg                                                   20


<210> 15559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACTGCTT

<400> 15559
atctccaaag cacaagtggc                                                   20


<210> 15560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGATT

<400> 15560
gttatcccgt cttctcacct                                                   20


<210> 15561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTAGATT

<400> 15561
gagttcacaa catctttgta                                                   20


<210> 15562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCTGCTT

<400> 15562
tagcattgac caccctttgc                                                   20


<210> 15563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGCTT

<400> 15563
tgcttagtgt cttcctttaa                                                   20


<210> 15564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGTGCTT

<400> 15564
cacagatcat gatgttaagc                                                   20


<210> 15565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGAAGTTT

<400> 15565
ataaaattag taaaatgaaa                                                   20


<210> 15566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCCTGTTT

<400> 15566
gactaatgaa aactcctgtg                                                   20


<210> 15567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGAGCTT

<400> 15567
tttcactttt attagaatgt                                                   20


<210> 15568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGTTT

<400> 15568
attcattttc acttttatta                                                   20


<210> 15569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGCTT

<400> 15569
tttcgatttt gcctttggtg                                                   20


<210> 15570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTCGATT

<400> 15570
aatctagcat tctttatctt                                                   20


<210> 15571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGAGATT

<400> 15571
ttttaaaaac cttcattgtt                                                   20


<210> 15572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGTTT

<400> 15572
ccatttgtat ttttagataa                                                   20


<210> 15573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGTTT

<400> 15573
gtgaggtttg acatggttac                                                   20


<210> 15574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAGGTTT

<400> 15574
tttgtttctt tgattactag                                                   20


<210> 15575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGATT

<400> 15575
gtttatttta atatttgttt                                                   20


<210> 15576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 15576
ttccccatgt ttattttaat                                                   20


<210> 15577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCATGTTT

<400> 15577
aataggccaa atttggttcc                                                   20


<210> 15578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGATT

<400> 15578
acttttgtta aaatctttgc                                                   20


<210> 15579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACTGATT

<400> 15579
actttcatcc agacaggcaa                                                   20


<210> 15580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGATT

<400> 15580
tgcctgggcc tcccaaagtt                                                   20


<210> 15581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGGGTTT

<400> 15581
ttttgtactt ttagtagaga                                                   20


<210> 15582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGTTT

<400> 15582
atattacaaa attaccctca                                                   20


<210> 15583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAGGCTT

<400> 15583
tataaacgaa ttcacgtgtt                                                   20


<210> 15584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACGTGTTT

<400> 15584
ttggcaatat aaacgaattc                                                   20


<210> 15585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGAGATT

<400> 15585
ttatacatgt tagaggacac                                                   20


<210> 15586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATTGATT

<400> 15586
cccttactgt taggattttg                                                   20


<210> 15587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGATT

<400> 15587
gtaaccctta ctgttaggat                                                   20


<210> 15588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAGGATT

<400> 15588
atttagtgta acccttactg                                                   20


<210> 15589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTGGATT

<400> 15589
acatctatct gtgtgtataa                                                   20


<210> 15590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGATT

<400> 15590
aaattaggtc aaataatttt                                                   20


<210> 15591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATTGATT

<400> 15591
acatgacaag aataaatatt                                                   20


<210> 15592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGATT

<400> 15592
ttaaacatga caagaataaa                                                   20


<210> 15593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGGGATT

<400> 15593
tactgccttt atatgcaaca                                                   20


<210> 15594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGAGATT

<400> 15594
ttgcctaagt attctctaat                                                   20


<210> 15595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGATT

<400> 15595
gttcagaata aatatttcca                                                   20


<210> 15596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGCTT

<400> 15596
tttcatgaac tgggagctga                                                   20


<210> 15597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGTTT

<400> 15597
aacatttcgc cactgtacat                                                   20


<210> 15598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTGGTTT

<400> 15598
gataactttt tttgtcttcc                                                   20


<210> 15599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGATT

<400> 15599
atctcctcac tagggtaatc                                                   20


<210> 15600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGCTT

<400> 15600
tgagtgttct agactgtagc                                                   20


<210> 15601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGCTT

<400> 15601
ctcagatgag tgttctagac                                                   20


<210> 15602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTTGTTT

<400> 15602
aataatccat ggattaatca                                                   20


<210> 15603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATGGATT

<400> 15603
acattattga ataaataatc                                                   20


<210> 15604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGTTT

<400> 15604
acatagagag ggaagtggga                                                   20


<210> 15605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATAGCTT

<400> 15605
gcagatatta tccttttggt                                                   20


<210> 15606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCTGTTT

<400> 15606
ttgcatctgt ctttatacag                                                   20


<210> 15607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCAGGTTT

<400> 15607
aaaggccagg ttggtgttgg                                                   20


<210> 15608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGTTT

<400> 15608
ttcatcttag tctttcaatt                                                   20


<210> 15609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGTTT

<400> 15609
gctttttttt ttctaaagtt                                                   20


<210> 15610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGCTT

<400> 15610
acttctcaat atcccacaat                                                   20


<210> 15611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGTTT

<400> 15611
tttaacttct caatatccca                                                   20


<210> 15612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGTTT

<400> 15612
cctttaccca gaattgatgt                                                   20


<210> 15613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 15613
gcaagcattc tactgaaatt                                                   20


<210> 15614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAACGTTT

<400> 15614
atcacataga tcaaggtata                                                   20


<210> 15615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTAAGTTT

<400> 15615
catggattat tctgtatctt                                                   20


<210> 15616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATGGATT

<400> 15616
ttgagactaa tgtcgaacaa                                                   20


<210> 15617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGTTT

<400> 15617
tggtgaattt tctgccatta                                                   20


<210> 15618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGCTT

<400> 15618
aattgatctt cttttgtact                                                   20


<210> 15619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGTTT

<400> 15619
atttttggaa gattataaaa                                                   20


<210> 15620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGAAGATT

<400> 15620
tagttagtta tcttattttt                                                   20


<210> 15621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGATT

<400> 15621
ttctctcatc acactgaaag                                                   20


<210> 15622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGATT

<400> 15622
ataggttgtc tgataataga                                                   20


<210> 15623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 15623
ttcttatacc tagaaatata                                                   20


<210> 15624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGTTT

<400> 15624
tgtgaaacat cttgtattct                                                   20


<210> 15625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGCTT

<400> 15625
gttctaaaga aacaaattcc                                                   20


<210> 15626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGATT

<400> 15626
caagttcatg cctcattttg                                                   20


<210> 15627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCTGCTT

<400> 15627
atcaaactca agtggatcct                                                   20


<210> 15628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATGGTTT

<400> 15628
tttcatttta aaacaagtaa                                                   20


<210> 15629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGATT

<400> 15629
tggtaattgg cacatttgtg                                                   20


<210> 15630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGCTT

<400> 15630
taattgtact tacattttat                                                   20


<210> 15631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTGGATT

<400> 15631
atttctaagt aattctatgg                                                   20


<210> 15632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGTTT

<400> 15632
cattctcaaa ttccaagcag                                                   20


<210> 15633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGTTT

<400> 15633
ttttatttca tcaacttatg                                                   20


<210> 15634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGCTT

<400> 15634
ttccttttta tctctaaata                                                   20


<210> 15635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGTTT

<400> 15635
cacttcccgc ttttttaaaa                                                   20


<210> 15636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCCGCTT

<400> 15636
ttatctaggg aataatcact                                                   20


<210> 15637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGCTT

<400> 15637
tggtaactaa ttcaaacaat                                                   20


<210> 15638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACAGCTT

<400> 15638
tataatatct tcttttattt                                                   20


<210> 15639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTGGTTT

<400> 15639
ttctacttaa gcagctgttt                                                   20


<210> 15640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCTGTTT

<400> 15640
agaacagttt ctacttaagc                                                   20


<210> 15641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACAGTTT

<400> 15641
aagcccagtg aaggtaacag                                                   20


<210> 15642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGTGTTT

<400> 15642
aaataatgta tctaaatata                                                   20


<210> 15643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGTGTTT

<400> 15643
acaatcttta ctgtaacttt                                                   20


<210> 15644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGAAGATT

<400> 15644
agaattggtg tcagataata                                                   20


<210> 15645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGGGATT

<400> 15645
acattaccta acataagtga                                                   20


<210> 15646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGATT

<400> 15646
tgtatttttt taggttacac                                                   20


<210> 15647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACATGCTT

<400> 15647
tttatgcttt ttaaaagtag                                                   20


<210> 15648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGCTT

<400> 15648
ggagggttca cgttagtatt                                                   20


<210> 15649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGATT

<400> 15649
tatgtgtact catctgatat                                                   20


<210> 15650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGTTT

<400> 15650
cctggtctat tgaatggaat                                                   20


<210> 15651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGATT

<400> 15651
gttcttgaac tcctgccctc                                                   20


<210> 15652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATAGATT

<400> 15652
tgtgttgttt ctattgaatt                                                   20


<210> 15653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGTTT

<400> 15653
gactcggagt tcaaaatatg                                                   20


<210> 15654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGTTT

<400> 15654
ttcaacttcc atttttttca                                                   20


<210> 15655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGTTT

<400> 15655
aaaaactttt ttttaccctt                                                   20


<210> 15656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGATGCTT

<400> 15656
agtgatataa gtgacatgaa                                                   20


<210> 15657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGATT

<400> 15657
ttaccaaaaa aaaaaaaaaa                                                   20


<210> 15658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAGGTTT

<400> 15658
ctgaggatgc tttagagctg                                                   20


<210> 15659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGATGCTT

<400> 15659
cttgacaaca gattgactga                                                   20


<210> 15660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACAGATT

<400> 15660
cttcttgctt attgcttgac                                                   20


<210> 15661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGCTT

<400> 15661
agttcttcct tcttcttgct                                                   20


<210> 15662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGCTT

<400> 15662
catcaagagt tcttccttct                                                   20


<210> 15663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGATT

<400> 15663
taggaaagac ctaatgtaac                                                   20


<210> 15664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGCGTTT

<400> 15664
attcctgaaa gttggaagat                                                   20


<210> 15665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGTGTTT

<400> 15665
ttaaaaaagt gttttctaag                                                   20


<210> 15666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGTTT

<400> 15666
aaatgaaatt ttttttaaaa                                                   20


<210> 15667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGATT

<400> 15667
atggaaatcg agctgtatat                                                   20


<210> 15668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAGGATT

<400> 15668
tatatattgt aactgttgct                                                   20


<210> 15669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGATT

<400> 15669
aattgtaatg ggaaaggcca                                                   20


<210> 15670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCATGATT

<400> 15670
aatctaaacc actcttcgga                                                   20


<210> 15671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGTTT

<400> 15671
acatgctcat atgaaatgtt                                                   20


<210> 15672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 15672
taatattaca tgctcatatg                                                   20


<210> 15673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCTGTTT

<400> 15673
ctcactactc taaactaaat                                                   20


<210> 15674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCAGGCTT

<400> 15674
gtgaatccag tattcaaaac                                                   20


<210> 15675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTTGCTT

<400> 15675
aacattttta gaatcagaaa                                                   20


<210> 15676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGTTT

<400> 15676
tcattctagg gatactcttg                                                   20


<210> 15677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGCTT

<400> 15677
taaaccaagt gttggaattt                                                   20


<210> 15678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 15678
agattacatt aatgatattt                                                   20


<210> 15679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGAGATT

<400> 15679
gatcattctt gtattctgtt                                                   20


<210> 15680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGCTT

<400> 15680
ctggagagac tgtaatattt                                                   20


<210> 15681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACCGTTT

<400> 15681
ccaatatttg acttcaagaa                                                   20


<210> 15682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCTGCTT

<400> 15682
ccccaaataa ttttcctgat                                                   20


<210> 15683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGGGTTT

<400> 15683
ctatagattt tccctatgtg                                                   20


<210> 15684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGATT

<400> 15684
acccacttcc cacctcatcc                                                   20


<210> 15685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAGGATT

<400> 15685
gtttacttca gtgatttttt                                                   20


<210> 15686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGTGATT

<400> 15686
attagtgttg gtgtttactt                                                   20


<210> 15687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGTGTTT

<400> 15687
tattaggtaa aaattagtgt                                                   20


<210> 15688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCAGTTT

<400> 15688
ctaataaatc atttgggaac                                                   20


<210> 15689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGCTT

<400> 15689
aacttattct cttaaataaa                                                   20


<210> 15690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACTGTTT

<400> 15690
aaaagttatc aaaggaaaca                                                   20


<210> 15691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTTGCTT

<400> 15691
gaaacaaaca agtaaacact                                                   20


<210> 15692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAAGATT

<400> 15692
tcatatcata gtccctctaa                                                   20


<210> 15693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGATT

<400> 15693
attgttgtaa ttttatcgaa                                                   20


<210> 15694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGAGATT

<400> 15694
tgcctcagcc tcctgagtag                                                   20


<210> 15695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGATT

<400> 15695
cagattttgg cagatcttcc                                                   20


<210> 15696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGATT

<400> 15696
tttatactga ctcaatctca                                                   20


<210> 15697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGTTT

<400> 15697
acctgcagga aaaaatcact                                                   20


<210> 15698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAAGATT

<400> 15698
aaaaattaat ggtacttcag                                                   20


<210> 15699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGCTT

<400> 15699
ctgattctat ggtgccttga                                                   20


<210> 15700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGATT

<400> 15700
aaacttttta ggttctcatg                                                   20


<210> 15701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTATGATT

<400> 15701
gttatcgttg ttgatgttaa                                                   20


<210> 15702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGTTT

<400> 15702
ctcatggtta gattaaggct                                                   20


<210> 15703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTAGATT

<400> 15703
tgtctgatat ttttctcatg                                                   20


<210> 15704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTTGTTT

<400> 15704
gtcgcaattt ctcaggcttt                                                   20


<210> 15705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAGGCTT

<400> 15705
ctctaggctg tcgcaatttc                                                   20


<210> 15706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTAGTTT

<400> 15706
ccttacccta ttcagagttc                                                   20


<210> 15707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACAGTTT

<400> 15707
atccagtttc ccctgttatt                                                   20


<210> 15708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGTTT

<400> 15708
cagtttcaat ataccccaca                                                   20


<210> 15709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GACAGTTT

<400> 15709
aaaatggtgc agatagtaag                                                   20


<210> 15710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGATT

<400> 15710
tgcttaaact tttgtcttgg                                                   20


<210> 15711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGCTT

<400> 15711
attctacatc tgtgatttcc                                                   20


<210> 15712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGATT

<400> 15712
atattagaat aattctacat                                                   20


<210> 15713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCATGATT

<400> 15713
atagaaaatt atcctcccag                                                   20


<210> 15714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTATGTTT

<400> 15714
attgtgactc cagtttagtt                                                   20


<210> 15715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGTTT

<400> 15715
taggactcag acattgtgac                                                   20


<210> 15716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACAGATT

<400> 15716
ttattctaaa agaaaataca                                                   20


<210> 15717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTATGCTT

<400> 15717
aacaacttaa aagatattta                                                   20


<210> 15718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGCTT

<400> 15718
tcattaagat ggatatgtaa                                                   20


<210> 15719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGGGCTT

<400> 15719
tttaaaatat tattgacaaa                                                   20


<210> 15720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGTTT

<400> 15720
tcagatccat ctggaaattt                                                   20


<210> 15721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGAGTTT

<400> 15721
cttggtgcca agacatagaa                                                   20


<210> 15722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGCTT

<400> 15722
ttcttattgt ctttgaatgt                                                   20


<210> 15723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGTTT

<400> 15723
ttgtacttct tattgtcttt                                                   20


<210> 15724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATCGTTT

<400> 15724
cccctgtatt ctccagattc                                                   20


<210> 15725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGATT

<400> 15725
attatttttc ccctgtattc                                                   20


<210> 15726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTGGTTT

<400> 15726
cacataggaa tggatataga                                                   20


<210> 15727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGATT

<400> 15727
tccaaagatg ttatcaggta                                                   20


<210> 15728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAGGATT

<400> 15728
aaatgctgta gacatcctgc                                                   20


<210> 15729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTGGCTT

<400> 15729
atttattctt gacacaaaat                                                   20


<210> 15730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTAAGCTT

<400> 15730
atggtaagat catcatatat                                                   20


<210> 15731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATGGCTT

<400> 15731
tcagaaaagt tcacaataac                                                   20


<210> 15732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCTGCTT

<400> 15732
actagtgatt aatatatgac                                                   20


<210> 15733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGTGATT

<400> 15733
agtgcaggat ttccaaacac                                                   20


<210> 15734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCAGGATT

<400> 15734
ggatgttatt taagcaaagt                                                   20


<210> 15735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGGGTTT

<400> 15735
gaaaatgaaa agttttgtca                                                   20


<210> 15736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGTTT

<400> 15736
aattctcaag acagaaaatg                                                   20


<210> 15737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGTTT

<400> 15737
tataaacgca atattaaata                                                   20


<210> 15738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGTTT

<400> 15738
gcaacagagt gagtgagacc                                                   20


<210> 15739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTCGCTT

<400> 15739
agctacttgg gaaggtggga                                                   20


<210> 15740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGCTT

<400> 15740
tgagaccttg tctctacaaa                                                   20


<210> 15741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGTTT

<400> 15741
taaatataat aaattacaac                                                   20


<210> 15742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGATT

<400> 15742
gtttttactc tacttaagtg                                                   20


<210> 15743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGTGTTT

<400> 15743
cataatggct ggctcaattc                                                   20


<210> 15744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGATT

<400> 15744
gtagtgagga aagaggattg                                                   20


<210> 15745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAGGATT

<400> 15745
tgaggtgttg tagtgaggaa                                                   20


<210> 15746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGATT

<400> 15746
ttatttctaa taagattata                                                   20


<210> 15747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGATT

<400> 15747
tatttgactg tttatttcta                                                   20


<210> 15748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GACTGTTT

<400> 15748
gataagatta tattatattt                                                   20


<210> 15749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGATT

<400> 15749
tgaagatggg cagtcaattg                                                   20


<210> 15750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTAGGATT

<400> 15750
aggctaaaga tacactgctt                                                   20


<210> 15751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACTGCTT

<400> 15751
aatgttacag gctaaagata                                                   20


<210> 15752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCTGCTT

<400> 15752
gctacaaaac caaatgacag                                                   20


<210> 15753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGTTT

<400> 15753
aaatgcatat atcctaaaaa                                                   20


<210> 15754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAAGTTT

<400> 15754
gtaaaacaaa cccccatgac                                                   20


<210> 15755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTCGCTT

<400> 15755
taaaaatgca tatatcatgt                                                   20


<210> 15756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAAGTTT

<400> 15756
caacttgagt tttcagaaaa                                                   20


<210> 15757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGAGTTT

<400> 15757
caatgattaa ttctctcaac                                                   20


<210> 15758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGATT

<400> 15758
ctttagtgta tattttagta                                                   20


<210> 15759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGTTT

<400> 15759
ctaatattct tcatttcttg                                                   20


<210> 15760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGCTT

<400> 15760
aaaccataaa acataaacct                                                   20


<210> 15761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGTTT

<400> 15761
acttaatgca ttttaaccta                                                   20


<210> 15762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGGGATT

<400> 15762
tttcatatac aaataatggt                                                   20


<210> 15763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCAGTTT

<400> 15763
tcaaaataag attaaagaaa                                                   20


<210> 15764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGATT

<400> 15764
taaaataatt gaaagtcaaa                                                   20


<210> 15765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGTGTTT

<400> 15765
acattaaggg aattcatgga                                                   20


<210> 15766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATCGCTT

<400> 15766
attgatggct ggtcacttaa                                                   20


<210> 15767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGTTT

<400> 15767
atttttttac tttaatcttt                                                   20


<210> 15768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 15768
taaaatcaag actaccttca                                                   20


<210> 15769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTGGTTT

<400> 15769
tgtgttgtaa ttgtttacct                                                   20


<210> 15770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGTTT

<400> 15770
tcatatagta ggtgtgttgt                                                   20


<210> 15771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGTTT

<400> 15771
aagccaaaga tgattttttt                                                   20


<210> 15772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGATT

<400> 15772
ccatcgaagg acaaagccaa                                                   20


<210> 15773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGAGTTT

<400> 15773
gtacaggaat agaaaatcta                                                   20


<210> 15774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGTTT

<400> 15774
cctttaaaat ttttaattag                                                   20


<210> 15775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGCTT

<400> 15775
atttaacctt tagaaggaaa                                                   20


<210> 15776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGATT

<400> 15776
ttatccacaa tacaagtaag                                                   20


<210> 15777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGAGGCTT

<400> 15777
gagaaaaaat attaataaaa                                                   20


<210> 15778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGAGATT

<400> 15778
atgagaaaat gtatgtaaat                                                   20


<210> 15779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGTGCTT

<400> 15779
atgctaagta ctttaaatca                                                   20


<210> 15780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCAGATT

<400> 15780
tattatgcag tagttagaag                                                   20


<210> 15781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTGGATT

<400> 15781
ttccaagaag gttggggact                                                   20


<210> 15782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGTTT

<400> 15782
tgcctgatca tctgaagtgg                                                   20


<210> 15783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCAAGCTT

<400> 15783
cattagactc tcagagaagt                                                   20


<210> 15784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGGGTTT

<400> 15784
aggccacagt gggttagatc                                                   20


<210> 15785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCTGTTT

<400> 15785
cacagatcca taaaacctgg                                                   20


<210> 15786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTAGCTT

<400> 15786
gtcgatttag agtatataag                                                   20


<210> 15787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGATT

<400> 15787
gtgttgtcga tttagagtat                                                   20


<210> 15788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTCGATT

<400> 15788
ataacagagt ggttgggtgt                                                   20


<210> 15789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGTTT

<400> 15789
attcttggat tgtgtaataa                                                   20


<210> 15790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTGGATT

<400> 15790
atagcactat taaataaatt                                                   20


<210> 15791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAAGTTT

<400> 15791
cattgagcaa tgaactataa                                                   20


<210> 15792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGAAGATT

<400> 15792
ctgttcattc tagataagaa                                                   20


<210> 15793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGCTT

<400> 15793
aatatagtca ctttagtcac                                                   20


<210> 15794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGCTT

<400> 15794
gggcaacaga atccatttga                                                   20


<210> 15795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGCTT

<400> 15795
ttcaataaaa tcttccttta                                                   20


<210> 15796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAGGATT

<400> 15796
ctactggtca ctgctgccac                                                   20


<210> 15797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGCTGTTT

<400> 15797
tgacaaaagg gaaatctaga                                                   20


<210> 15798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAGGCTT

<400> 15798
gggtactcat gcattcattg                                                   20


<210> 15799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGAGATT

<400> 15799
actggctgtc ccaagccaaa                                                   20


<210> 15800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGATT

<400> 15800
tttctcatat taagcaaaga                                                   20


<210> 15801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTTGTTT

<400> 15801
aactgtcata gccaaaagga                                                   20


<210> 15802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGAGCTT

<400> 15802
gcaaaactgt catagccaaa                                                   20


<210> 15803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGCTT

<400> 15803
attttcaagt gattcagaag                                                   20


<210> 15804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGATT

<400> 15804
aggtcaagtg attaattttc                                                   20


<210> 15805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGATT

<400> 15805
aaatcactac ttctgaggtc                                                   20


<210> 15806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGTTT

<400> 15806
ttctgcattt acagactgca                                                   20


<210> 15807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATGGATT

<400> 15807
tatgatagga acaatattga                                                   20


<210> 15808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGTTT

<400> 15808
ggacggactt agtccaaaat                                                   20


<210> 15809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGATT

<400> 15809
tggttttgtt atatttacat                                                   20


<210> 15810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTGGTTT

<400> 15810
cctgcaagat taaataatgg                                                   20


<210> 15811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATGGCTT

<400> 15811
atggtcctgc aagattaaat                                                   20


<210> 15812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCAAGATT

<400> 15812
tatggaaggc ttatggtcct                                                   20


<210> 15813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAGGCTT

<400> 15813
gcatcatcag gttgcttatg                                                   20


<210> 15814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTTGCTT

<400> 15814
gtagtaagtt agcatcatca                                                   20


<210> 15815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGTTT

<400> 15815
aatattttag agtattgaaa                                                   20


<210> 15816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAAGTTT

<400> 15816
ttaaaatatt ttagagtatt                                                   20


<210> 15817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTGGATT

<400> 15817
tttcttaaaa taaatatatt                                                   20


<210> 15818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTGGTTT

<400> 15818
gaattatcct gttgaggacc                                                   20


<210> 15819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAAGATT

<400> 15819
agataaacaa ttagtaaatt                                                   20


<210> 15820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAGGCTT

<400> 15820
tgttacattg tagggggaac                                                   20


<210> 15821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGCTT

<400> 15821
agtcaataca tgttcagaag                                                   20


<210> 15822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGTTT

<400> 15822
aataaaaatt catgacaatg                                                   20


<210> 15823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGCTGTTT

<400> 15823
gtttatccct tgtatgccaa                                                   20


<210> 15824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGTTT

<400> 15824
tattaaagat aaaatggatg                                                   20


<210> 15825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGCTT

<400> 15825
cattgttaat tgatgccctc                                                   20


<210> 15826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAGGATT

<400> 15826
gcattccata tcttttagca                                                   20


<210> 15827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTAGTTT

<400> 15827
tagatgcagt tgagagaatt                                                   20


<210> 15828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTATGATT

<400> 15828
aagaaattgt tgcagagacc                                                   20


<210> 15829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTTGCTT

<400> 15829
aataattttc tcataaaaag                                                   20


<210> 15830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 15830
tacagagatt accacagctc                                                   20


<210> 15831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGAGATT

<400> 15831
aataactcca tttactgtta                                                   20


<210> 15832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAGGTTT

<400> 15832
cttccacttt gtatatcata                                                   20


<210> 15833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTATGATT

<400> 15833
taacagctaa gcaaatagat                                                   20


<210> 15834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGTTT

<400> 15834
aagctctttg tgcagcatac                                                   20


<210> 15835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTAAGTTT

<400> 15835
tcaaaaatgt caaaatgcaa                                                   20


<210> 15836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGAGATT

<400> 15836
tgactgacag tgacaaagct                                                   20


<210> 15837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGAGTTT

<400> 15837
actcttgttt atgtttagtt                                                   20


<210> 15838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGTTT

<400> 15838
ttcattggct caactcttgt                                                   20


<210> 15839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGTTT

<400> 15839
aatcctttca ttggctcaac                                                   20


<210> 15840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAAGTTT

<400> 15840
gttcaattta ctgtaagttc                                                   20


<210> 15841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGATT

<400> 15841
tcttgctggc aaacagaacg                                                   20


<210> 15842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAACGTTT

<400> 15842
ttctctcttg ctggcaaaca                                                   20


<210> 15843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGCTT

<400> 15843
aaaccttata taatgtcagc                                                   20


<210> 15844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCATGTTT

<400> 15844
taagtgtccc actctagtga                                                   20


<210> 15845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCAAGCTT

<400> 15845
gttagcaagt gaaggccagt                                                   20


<210> 15846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTATGCTT

<400> 15846
taactgcctc actccagtaa                                                   20


<210> 15847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCATGTTT

<400> 15847
tgaaattctc attccagtgg                                                   20


<210> 15848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCAAGTTT

<400> 15848
gaaaagaatg gtctttaagc                                                   20


<210> 15849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGCTT

<400> 15849
aaactctgta catgctcaga                                                   20


<210> 15850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTAGATT

<400> 15850
accgtatact ttaaatcatc                                                   20


<210> 15851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGGGATT

<400> 15851
aattgtccct cagtatcagt                                                   20


<210> 15852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCAGGTTT

<400> 15852
caatccctat cctctttcta                                                   20


<210> 15853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 15853
ttaaatgcca acattagcca                                                   20


<210> 15854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATCGCTT

<400> 15854
gcgacagtaa ttggtgatta                                                   20


<210> 15855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGTGATT

<400> 15855
catttttctg cgacagtaat                                                   20


<210> 15856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTAGCTT

<400> 15856
acagcctaaa tttcctgtat                                                   20


<210> 15857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTGGCTT

<400> 15857
gattttgtcc tgcacccttt                                                   20


<210> 15858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGATT

<400> 15858
atgaaactag gaaatgtatg                                                   20


<210> 15859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATCGATT

<400> 15859
aggtttctca acctcagctt                                                   20


<210> 15860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCAGCTT

<400> 15860
ctaagcatag gtttctcaac                                                   20


<210> 15861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAGGTTT

<400> 15861
ggtgaaattg tggtctaagc                                                   20


<210> 15862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGCCGTTT

<400> 15862
aaaacccagc cagcctctca                                                   20


<210> 15863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGTGATT

<400> 15863
tgattacaac tgaaaacagt                                                   20


<210> 15864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGATT

<400> 15864
ttaatcactg gatgacactg                                                   20


<210> 15865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGAGCTT

<400> 15865
ataaaaggag taccaaagct                                                   20


<210> 15866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAAGCTT

<400> 15866
gtgtactata aaaggagtac                                                   20


<210> 15867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCTGCTT

<400> 15867
aaatatggac ttgatcattt                                                   20


<210> 15868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGAGTTT

<400> 15868
ccctctagac tatgtgaaaa                                                   20


<210> 15869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCAGTTT

<400> 15869
tccatacccc caccaatcat                                                   20


<210> 15870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGTTT

<400> 15870
aaccacatac ctatacctca                                                   20


<210> 15871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTAGTTT

<400> 15871
tgttctttaa gcctcatcct                                                   20


<210> 15872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTGGATT

<400> 15872
tcaaacacag gatgtccaaa                                                   20


<210> 15873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCATGTTT

<400> 15873
cttccattca agctgttttg                                                   20


<210> 15874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCTGTTT

<400> 15874
ttttaaaata cttccattca                                                   20


<210> 15875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGTTT

<400> 15875
tcaaaccaat ttctaacccc                                                   20


<210> 15876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTGGCTT

<400> 15876
ctggattaaa aagaaggtag                                                   20


<210> 15877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTGGATT

<400> 15877
ctagcttttc agtgttggag                                                   20


<210> 15878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTAGCTT

<400> 15878
aagtaactta actaaggtga                                                   20


<210> 15879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGTGTTT

<400> 15879
ttggttcaag tatgattcta                                                   20


<210> 15880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTATGATT

<400> 15880
ttgagttctt attggttcaa                                                   20


<210> 15881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCAGTTT

<400> 15881
acattttgaa gcatttatgt                                                   20


<210> 15882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTGGTTT

<400> 15882
ctactcctcc gtttgaaagc                                                   20


<210> 15883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCCGTTT

<400> 15883
gagaatgcct ggcactactc                                                   20


<210> 15884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATGGATT

<400> 15884
tgcatagata tgctttgctg                                                   20


<210> 15885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGCTT

<400> 15885
atctccttgt atttgcatag                                                   20


<210> 15886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACTGTTT

<400> 15886
aacaaatagc ataagtatag                                                   20


<210> 15887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGATT

<400> 15887
tatcatactg gtgttaattt                                                   20


<210> 15888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTAAGATT

<400> 15888
taaaaaatga tgtaatttaa                                                   20


<210> 15889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACTGATT

<400> 15889
tgagacgcat tctacaaaat                                                   20


<210> 15890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGTTT

<400> 15890
tctaattcca tagataacgc                                                   20


<210> 15891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAACGCTT

<400> 15891
aaagtatcta attccataga                                                   20


<210> 15892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGTTT

<400> 15892
agccatgtat ttctgcattt                                                   20


<210> 15893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACTGATT

<400> 15893
agtttaccag ataaactact                                                   20


<210> 15894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GACAGTTT

<400> 15894
ttgttttatt taattacaag                                                   20


<210> 15895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATTGTTT

<400> 15895
ttttcaatta acttcctggg                                                   20


<210> 15896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGGGATT

<400> 15896
gcttttttca attaacttcc                                                   20


<210> 15897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCAGGCTT

<400> 15897
cttctaggtg ttcctgatgg                                                   20


<210> 15898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGTGGCTT

<400> 15898
gcttaaacag accaacaaag                                                   20


<210> 15899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGCTT

<400> 15899
gaagagcagt gtgccagaaa                                                   20


<210> 15900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGATT

<400> 15900
caacttacct gtcattttaa                                                   20


<210> 15901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTTGTTT

<400> 15901
atatcagaga gtcagctatt                                                   20


<210> 15902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGCTT

<400> 15902
tgcatgtctt tccccaggca                                                   20


<210> 15903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGCTT

<400> 15903
gtttttgtta atttaaatat                                                   20


<210> 15904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGTTT

<400> 15904
cttgttcagg tgccagggac                                                   20


<210> 15905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACTGTTT

<400> 15905
atttacaagt aattaacaaa                                                   20


<210> 15906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCTGATT

<400> 15906
agaagttatt taatttaaaa                                                   20


<210> 15907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGTGCTT

<400> 15907
ctgtagagta aaccctagcc                                                   20


<210> 15908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGTTT

<400> 15908
tcccatttgt tttctctttt                                                   20


<210> 15909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 15909
attaaggaga ctggtttccc                                                   20


<210> 15910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTGGTTT

<400> 15910
cactcatttt cattaaggag                                                   20


<210> 15911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAGGCTT

<400> 15911
tcttcccaag atgtgttatt                                                   20


<210> 15912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGATT

<400> 15912
gtcaaatagt cgatataaat                                                   20


<210> 15913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCATGTTT

<400> 15913
gatatgtcaa tgttaaaatg                                                   20


<210> 15914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTAGTTT

<400> 15914
gaaagtaaaa ctgagtgaaa                                                   20


<210> 15915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCCTGATT

<400> 15915
ctaagtctta acgattagaa                                                   20


<210> 15916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAACGATT

<400> 15916
atgattagag gactaagtct                                                   20


<210> 15917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGATT

<400> 15917
gaaagaaaga aaacgttgtg                                                   20


<210> 15918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCCAGTTT

<400> 15918
attttccatt tgttccccag                                                   20


<210> 15919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGCTT

<400> 15919
ttcttgaatg tgaaatttcc                                                   20


<210> 15920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCAGTTT

<400> 15920
agaaaaatga aaggaatctt                                                   20


<210> 15921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGTTT

<400> 15921
ctgacttctg gtcatagctt                                                   20


<210> 15922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATAGCTT

<400> 15922
ctcaaagcct gacttctggt                                                   20


<210> 15923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGTTT

<400> 15923
ttattcacag agcagctgta                                                   20


<210> 15924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGTTT

<400> 15924
gaatttattc acagagcagc                                                   20


<210> 15925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTGGCTT

<400> 15925
tattgatgaa atgaatatgg                                                   20


<210> 15926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATGGCTT

<400> 15926
aatgttattg atgaaatgaa                                                   20


<210> 15927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GACAGATT

<400> 15927
ttgtatttcc tgaatgaaat                                                   20


<210> 15928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTATGCTT

<400> 15928
gtattgacat tattctgcaa                                                   20


<210> 15929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGCGCTT

<400> 15929
acatacgtgc tgatgtgttt                                                   20


<210> 15930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGTTT

<400> 15930
tagtctatac atacgtgctg                                                   20


<210> 15931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAACGATT

<400> 15931
ttaaatagcc caaagattct                                                   20


<210> 15932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAAGATT

<400> 15932
tgtacaaact ttaaatagcc                                                   20


<210> 15933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGTTT

<400> 15933
ctattactga ttgaagtcat                                                   20


<210> 15934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACTGATT

<400> 15934
attgactaga ttggttctat                                                   20


<210> 15935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTAGATT

<400> 15935
tctccatatg gcattcattg                                                   20


<210> 15936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGTTT

<400> 15936
ccacactata attaaagcca                                                   20


<210> 15937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACAGTTT

<400> 15937
taatggttta atctttaaaa                                                   20


<210> 15938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATGGTTT

<400> 15938
agaaaatttt ctctgactct                                                   20


<210> 15939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATTGTTT

<400> 15939
tgttttacac tgcatgtgta                                                   20


<210> 15940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGATT

<400> 15940
catatgtttt acactgcatg                                                   20


<210> 15941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGTTT

<400> 15941
ttgtgtatat ttttaaatgc                                                   20


<210> 15942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGTTT

<400> 15942
aaaataatga taaaataaaa                                                   20


<210> 15943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATAGATT

<400> 15943
ttattcaaga tcaaggtaat                                                   20


<210> 15944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGTTT

<400> 15944
ttgtcttcat tcttatcttt                                                   20


<210> 15945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGCTT

<400> 15945
acacctaaga acaatgctgg                                                   20


<210> 15946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGTTT

<400> 15946
tgtatgcaaa gggcataatc                                                   20


<210> 15947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGAAGCTT

<400> 15947
tgtttgcctg agttctccag                                                   20


<210> 15948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACATGTTT

<400> 15948
gaaggtaggg atggacaggg                                                   20


<210> 15949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAACGTTT

<400> 15949
caatgcactc tatgtgctaa                                                   20


<210> 15950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTAGTTT

<400> 15950
taatctgatg ttgaaagaat                                                   20


<210> 15951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGATT

<400> 15951
gttttctttt tgaaataaaa                                                   20


<210> 15952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGTTT

<400> 15952
tttatatgtg aagcctttac                                                   20


<210> 15953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGGGTTT

<400> 15953
tgtaaagtct cctaaaagct                                                   20


<210> 15954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGCTT

<400> 15954
caacatatgt aaagtctcct                                                   20


<210> 15955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGCTT

<400> 15955
tcctcaaacc aaaggttccc                                                   20


<210> 15956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGTGGTTT

<400> 15956
cactttttca atgaggaaac                                                   20


<210> 15957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGATT

<400> 15957
cccctcggcc tcccaaagtg                                                   20


<210> 15958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGATT

<400> 15958
cattataaag catctacata                                                   20


<210> 15959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGCTT

<400> 15959
taatatgtat tgagtggttc                                                   20


<210> 15960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGAGATT

<400> 15960
aagaattgac acttagcatt                                                   20


<210> 15961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGATT

<400> 15961
ttactgtaac taaagcaaag                                                   20


<210> 15962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAAGTTT

<400> 15962
tgatgttact gtaactaaag                                                   20


<210> 15963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTTGATT

<400> 15963
tgtctgtgct agtttagttt                                                   20


<210> 15964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGTTT

<400> 15964
tttctttttg tctgtgctag                                                   20


<210> 15965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTAGTTT

<400> 15965
gtacttttct ttttgtctgt                                                   20


<210> 15966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAGGCTT

<400> 15966
ttgatatatt tttaacttta                                                   20


<210> 15967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCAGCTT

<400> 15967
tcttttttag tagtgctatt                                                   20


<210> 15968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGTTT

<400> 15968
tttcatcaaa ggcttttctt                                                   20


<210> 15969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGCTT

<400> 15969
tcgtaagatg ctgtttcatc                                                   20


<210> 15970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCTGTTT

<400> 15970
aagtccttag tttcgtaaga                                                   20


<210> 15971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTAGTTT

<400> 15971
gaatgtacaa attacaagtc                                                   20


<210> 15972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGAGTTT

<400> 15972
tataatgatg atttatagag                                                   20


<210> 15973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGATGATT

<400> 15973
ctgatgaatt gctagtataa                                                   20


<210> 15974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTAGATT

<400> 15974
taaaaggagc ttcaaaacaa                                                   20


<210> 15975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGAGCTT

<400> 15975
acatgaaaag gatcactaaa                                                   20


<210> 15976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTGGCTT

<400> 15976
tgtttgcaca aaggattgta                                                   20


<210> 15977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGATT

<400> 15977
ttttctttcc ctgtttgcac                                                   20


<210> 15978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCCTGTTT

<400> 15978
atcttgattg ttttttcttt                                                   20


<210> 15979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATTGTTT

<400> 15979
acctcttagt ttggtatctt                                                   20


<210> 15980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGATT

<400> 15980
ttccacctct tagtttggta                                                   20


<210> 15981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTAGTTT

<400> 15981
agtgatggaa atttccacct                                                   20


<210> 15982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGGGTTT

<400> 15982
gccttctcct cccacatatt                                                   20


<210> 15983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGTTT

<400> 15983
cacatcaggg gcagaggatt                                                   20


<210> 15984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAGGATT

<400> 15984
tgctgcttca catcaggggc                                                   20


<210> 15985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCTGCTT

<400> 15985
aaatgctttc tgtcttacac                                                   20


<210> 15986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGCTT

<400> 15986
gataacaaag gacatgattc                                                   20


<210> 15987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACATGATT

<400> 15987
tctggcaaag ataacaaagg                                                   20


<210> 15988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGCTT

<400> 15988
ttccatttag ttcctcgaga                                                   20


<210> 15989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAAGCTT

<400> 15989
catgaggtct gaaatgtagt                                                   20


<210> 15990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATTGATT

<400> 15990
tatatatgtc ttgattcatt                                                   20


<210> 15991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGATT

<400> 15991
aagatatata tgtcttgatt                                                   20


<210> 15992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGATT

<400> 15992
acataatcaa gatatatatg                                                   20


<210> 15993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGAGATT

<400> 15993
tcctgaagaa atcctaaaaa                                                   20


<210> 15994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCTGCTT

<400> 15994
ttacatttgt agcacagggt                                                   20


<210> 15995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGCTT

<400> 15995
agttttcaaa agaggcggat                                                   20


<210> 15996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAAGTTT

<400> 15996
catactgacc tcaacgtggt                                                   20


<210> 15997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTAGTTT

<400> 15997
cctagattgt ttttctggaa                                                   20


<210> 15998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATTGTTT

<400> 15998
ctattaattt gaaatgccta                                                   20


<210> 15999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTAGATT

<400> 15999
tcctctatta atttgaaatg                                                   20


<210> 16000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGTTT

<400> 16000
ctgtttttgt ttgtatgttt                                                   20


<210> 16001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGTTT

<400> 16001
atatctgttt ttgtttgtat                                                   20


<210> 16002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTATGTTT

<400> 16002
aattatatct gtttttgttt                                                   20


<210> 16003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 16003
tttctggcaa ttatatctgt                                                   20


<210> 16004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCTGTTT

<400> 16004
caggattttc tggcaattat                                                   20


<210> 16005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAGGATT

<400> 16005
aataaatacc ttcatcttca                                                   20


<210> 16006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCCCGTTT

<400> 16006
ataaaaagat atagcatagg                                                   20


<210> 16007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTTGCTT

<400> 16007
tgtaatgccc atgtttaaac                                                   20


<210> 16008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCATGTTT

<400> 16008
gaaagtgtaa tgtgtaatgc                                                   20


<210> 16009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTTGTTT

<400> 16009
tcagggagga agctagattc                                                   20


<210> 16010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTAGATT

<400> 16010
ctcccaaatt cagggaggaa                                                   20


<210> 16011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGTTT

<400> 16011
aaggtattct tctccatctt                                                   20


<210> 16012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTTGTTT

<400> 16012
tcactgactc ttgttttctt                                                   20


<210> 16013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGCTT

<400> 16013
ggcatcactg actcttgttt                                                   20


<210> 16014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGTTT

<400> 16014
agtggtaggg catcactgac                                                   20


<210> 16015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGATT

<400> 16015
ggcctatggt ctttttgaga                                                   20


<210> 16016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGTTT

<400> 16016
gttcactaat gagggagaag                                                   20


<210> 16017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAGGCTT

<400> 16017
ctgagataaa taaaaggtat                                                   20


<210> 16018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTTGTTT

<400> 16018
ttttctactg gacagtattg                                                   20


<210> 16019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAAGTTT

<400> 16019
ctcaagtatt atgtacttta                                                   20


<210> 16020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCCAGCTT

<400> 16020
acaggagata catatttttt                                                   20


<210> 16021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTGGTTT

<400> 16021
tcccttaggt cactaatgtg                                                   20


<210> 16022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGCTT

<400> 16022
tgcagtccct taggtcacta                                                   20


<210> 16023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTAAGTTT

<400> 16023
ctgcacctgc tccatattta                                                   20


<210> 16024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAGGTTT

<400> 16024
acgctttaga gagaacaatg                                                   20


<210> 16025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCACGCTT

<400> 16025
agcttgattc ccacctgaac                                                   20


<210> 16026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTTGATT

<400> 16026
tatcatatac ttttcaatga                                                   20


<210> 16027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGAGCTT

<400> 16027
tatatatcat atacttttca                                                   20


<210> 16028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTGGCTT

<400> 16028
tgtctttctg atgttcctct                                                   20


<210> 16029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCTGTTT

<400> 16029
ctcaaaacta ttgtgcaaat                                                   20


<210> 16030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGCTT

<400> 16030
gtgtgaggtt caaacaattt                                                   20


<210> 16031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGATT

<400> 16031
aagagtgatg gaccagtgcc                                                   20


<210> 16032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTGGATT

<400> 16032
gagcaatgat tcatgaaccc                                                   20


<210> 16033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGATT

<400> 16033
tgtcaagagc tttctaagag                                                   20


<210> 16034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGCTT

<400> 16034
aaacctatcc cctgggtgtc                                                   20


<210> 16035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGGTGATT

<400> 16035
ctaggcatgt tgatctccca                                                   20


<210> 16036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAGGCTT

<400> 16036
attctaaata gcacagaact                                                   20


<210> 16037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGTTT

<400> 16037
ttacttcata taaagtctta                                                   20


<210> 16038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGATT

<400> 16038
ttgttttccg tgtcatcatt                                                   20


<210> 16039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 16039
gtaatttaga cacttcctgg                                                   20


<210> 16040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTGGATT

<400> 16040
tccaggtaat ttagacactt                                                   20


<210> 16041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTACGATT

<400> 16041
ctgtgaagaa tggggctggg                                                   20


<210> 16042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGTTT

<400> 16042
ttatctggca ctccgatcct                                                   20


<210> 16043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGTTT

<400> 16043
ctaccatctt gccataggaa                                                   20


<210> 16044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACAGATT

<400> 16044
tgcctcttcc tctctggagc                                                   20


<210> 16045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTAGTTT

<400> 16045
atgttggaag actttctatt                                                   20


<210> 16046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGAGTTT

<400> 16046
aataagagta tatgaaaaat                                                   20


<210> 16047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGATT

<400> 16047
aaagtataat caatagccct                                                   20


<210> 16048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTTGATT

<400> 16048
agcaaaggga aagggtttag                                                   20


<210> 16049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGGGTTT

<400> 16049
aaagagaaaa agcaaaggga                                                   20


<210> 16050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGATGATT

<400> 16050
ataagctatt gagaagccac                                                   20


<210> 16051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTAGGTTT

<400> 16051
gaggtttaag aaaagtagtt                                                   20


<210> 16052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGAGGTTT

<400> 16052
ctgcacccgg ccactacttt                                                   20


<210> 16053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGGGATT

<400> 16053
cacctctgcc tcccaaagtg                                                   20


<210> 16054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGAGTTT

<400> 16054
tgtatttttt ttagtagaga                                                   20


<210> 16055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCGGGATT

<400> 16055
tgcctcagcc ttccgaggag                                                   20


<210> 16056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGCGATT

<400> 16056
caatctccgc tcctgggttc                                                   20


<210> 16057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGGAGTTT

<400> 16057
tgtttgtttg tttgttttga                                                   20


<210> 16058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGTTT

<400> 16058
gtttgtttgt ttgtttgttt                                                   20


<210> 16059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGTTT

<400> 16059
ttttgtttgt ttgtttgttt                                                   20


<210> 16060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGTTT

<400> 16060
agttttttgt ttgtttgttt                                                   20


<210> 16061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGTTT

<400> 16061
gaggagtttt ttgtttgttt                                                   20


<210> 16062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGTTT

<400> 16062
atgagaggag ttttttgttt                                                   20


<210> 16063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGTTT

<400> 16063
catgatgaga ggagtttttt                                                   20


<210> 16064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 16064
aaatcatgat gagaggagtt                                                   20


<210> 16065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGAGTTT

<400> 16065
ttatgtcaaa tcatgatgag                                                   20


<210> 16066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGGTGATT

<400> 16066
gatggtcaca gcttggggga                                                   20


<210> 16067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACAGCTT

<400> 16067
agaaagatga ataagatggt                                                   20


<210> 16068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGATT

<400> 16068
tatacaactg aataagtatt                                                   20


<210> 16069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGTTT

<400> 16069
tttgaactct ttctcacttt                                                   20


<210> 16070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTAGATT

<400> 16070
aaaatgaagt ggaagtacac                                                   20


<210> 16071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGAGATT

<400> 16071
acctaattta aaagtttgta                                                   20


<210> 16072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGTTT

<400> 16072
ggaatattgt gacctaattt                                                   20


<210> 16073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGGGTTT

<400> 16073
cattgccctt atagtctact                                                   20


<210> 16074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGATT

<400> 16074
tgcctcggcc ttccaaagtg                                                   20


<210> 16075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGGGTTT

<400> 16075
ttttgtattt ttagtagaga                                                   20


<210> 16076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGATT

<400> 16076
tgcctcagcc tcctgagtag                                                   20


<210> 16077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGGAGTTT

<400> 16077
tttttatttt ttttgtgaga                                                   20


<210> 16078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGTTT

<400> 16078
agtccacgaa ccaggagtag                                                   20


<210> 16079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 16079
gttgaaagca gtcattttgt                                                   20


<210> 16080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGCTT

<400> 16080
ataatctctc tccttacata                                                   20


<210> 16081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATAGTTT

<400> 16081
aattcctgga ggggcatccc                                                   20


<210> 16082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTAGTTT

<400> 16082
ctgaggcaca tatagggata                                                   20


<210> 16083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGTTT

<400> 16083
aactataatt ttgttgtgtt                                                   20


<210> 16084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGTTT

<400> 16084
gaccagcaac tataattttg                                                   20


<210> 16085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGATT

<400> 16085
atagttaaat aaataatagg                                                   20


<210> 16086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGTTT

<400> 16086
ggcaagatga ttgacagaga                                                   20


<210> 16087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGATT

<400> 16087
ctggtgatca ccagtgggca                                                   20


<210> 16088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGAGCTT

<400> 16088
atatacttaa aatgttcttt                                                   20


<210> 16089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGATT

<400> 16089
tactcttagt tataaccatc                                                   20


<210> 16090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCTGTTT

<400> 16090
atatttgtag ttgaaataat                                                   20


<210> 16091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTCGCTT

<400> 16091
aaagtcaccg tcaaaatagc                                                   20


<210> 16092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGTTT

<400> 16092
aaaagctttt tttgttaaaa                                                   20


<210> 16093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGCTT

<400> 16093
aattactctt agcactctga                                                   20


<210> 16094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGCTT

<400> 16094
gtgtatgtct gtgtgtgcgt                                                   20


<210> 16095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCAGATT

<400> 16095
ggaagccttt gtgtcgccaa                                                   20


<210> 16096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGCTT

<400> 16096
tattcttctt tttaggcttt                                                   20


<210> 16097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAGGCTT

<400> 16097
gttttgtatt attcttcttt                                                   20


<210> 16098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 16098
caccaccctg atgtgtgggt                                                   20


<210> 16099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGGGTTT

<400> 16099
tcatttcacc accctgatgt                                                   20


<210> 16100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 16100
gttgataaac tttataagga                                                   20


<210> 16101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACATGTTT

<400> 16101
atcttttgct tgaaaaagaa                                                   20


<210> 16102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGCTT

<400> 16102
cttaccacat gacccacatc                                                   20


<210> 16103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGATT

<400> 16103
gaaatcacat ccattagata                                                   20


<210> 16104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGCTT

<400> 16104
gtgctcagct gaaccagagc                                                   20


<210> 16105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCTGCTT

<400> 16105
gccagggaat tctccaccag                                                   20


<210> 16106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 16106
atttaaaact ccataatgag                                                   20


<210> 16107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGAGATT

<400> 16107
taattattta aaactccata                                                   20


<210> 16108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGAGCTT

<400> 16108
atggtatcag gttgatgatg                                                   20


<210> 16109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACGTGTTT

<400> 16109
aagtactatt ttaacattgt                                                   20


<210> 16110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGGGCTT

<400> 16110
ttctccccat tttacgggtt                                                   20


<210> 16111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACGGGTTT

<400> 16111
tagttttttc tccccatttt                                                   20


<210> 16112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGTTT

<400> 16112
acttaccaat ataccaactt                                                   20


<210> 16113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGATT

<400> 16113
tcagataaat ccatgagtag                                                   20


<210> 16114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGCTT

<400> 16114
gttatttaga tcacattgta                                                   20


<210> 16115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGTGTTT

<400> 16115
tcaccatcat taatttacca                                                   20


<210> 16116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTAGGCTT

<400> 16116
tactgcagtc tgcttttatt                                                   20


<210> 16117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCTGCTT

<400> 16117
ttagtttcag tcttactgca                                                   20


<210> 16118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTAGTTT

<400> 16118
gctaatgcct tatttggttt                                                   20


<210> 16119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGTTT

<400> 16119
aggtccttgc taatgcctta                                                   20


<210> 16120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTTGCTT

<400> 16120
attgatgttt tgtgattgaa                                                   20


<210> 16121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGCTT

<400> 16121
aatgattgat gttttgtgat                                                   20


<210> 16122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGATT

<400> 16122
tttaattaat gattgatgtt                                                   20


<210> 16123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGATGTTT

<400> 16123
gatgtacttt aattaatgat                                                   20


<210> 16124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGATT

<400> 16124
aaagcaagat gtactttaat                                                   20


<210> 16125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGATT

<400> 16125
attccttgtc ttacttttca                                                   20


<210> 16126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGTTT

<400> 16126
tggaattcct tgtcttactt                                                   20


<210> 16127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCTGATT

<400> 16127
gctcatagtt ctaaaatagg                                                   20


<210> 16128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACCCGTTT

<400> 16128
agcagcacag aaatctggag                                                   20


<210> 16129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACAGTTT

<400> 16129
ttaaatcttg gtttagagaa                                                   20


<210> 16130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTGGTTT

<400> 16130
cgatcctgga acttttaaat                                                   20


<210> 16131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGATGTTT

<400> 16131
cttttttcaa aagaaatttg                                                   20


<210> 16132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGATT

<400> 16132
cacttcggcc tcccaaagtg                                                   20


<210> 16133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGGGTTT

<400> 16133
tttttgtatt tttgaaggga                                                   20


<210> 16134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 16134
ttgcttggtg ttaggcaact                                                   20


<210> 16135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTTGCTT

<400> 16135
atattacata atttattcaa                                                   20


<210> 16136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGAAGATT

<400> 16136
ataatttttt tttagtcatg                                                   20


<210> 16137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGATT

<400> 16137
ttctgtacat agtggggagc                                                   20


<210> 16138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGTTT

<400> 16138
taagacaaat ttcctgtcta                                                   20


<210> 16139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGCTT

<400> 16139
attagatagc gtgcttcttc                                                   20


<210> 16140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCGTGCTT

<400> 16140
aaaggcaata taattagata                                                   20


<210> 16141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 16141
tgatagttat ggattattgt                                                   20


<210> 16142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATGGATT

<400> 16142
gatgtaaaat caatgatagt                                                   20


<210> 16143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGCGTTT

<400> 16143
agagtgccat aaattaaaga                                                   20


<210> 16144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGTTT

<400> 16144
atggaaattg ctttgttttt                                                   20


<210> 16145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGTTT

<400> 16145
ccataaaagg atggaaattg                                                   20


<210> 16146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGCTT

<400> 16146
agcctccata aaaggatgga                                                   20


<210> 16147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGTTT

<400> 16147
aattaaacct aagcagatag                                                   20


<210> 16148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCTGTTT

<400> 16148
tctgaccaaa cttttaacct                                                   20


<210> 16149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGGGATT

<400> 16149
ctgctgtgaa cttaaaaact                                                   20


<210> 16150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGTGCTT

<400> 16150
ataaaatatc tacaatttta                                                   20


<210> 16151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGTTT

<400> 16151
ttggcaattt gtccttaaat                                                   20


<210> 16152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAAGATT

<400> 16152
tgatcgcttt gttggatgtt                                                   20


<210> 16153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATCGCTT

<400> 16153
tctaaaacaa ttaaatactt                                                   20


<210> 16154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTAGGTTT

<400> 16154
atctaggatt gtatctgtgc                                                   20


<210> 16155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTAGGATT

<400> 16155
agttagggtt aatcaaccat                                                   20


<210> 16156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAAGCTT

<400> 16156
cttctccctg ttatttgcgt                                                   20


<210> 16157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGCTT

<400> 16157
tggaaatgaa atcttttcag                                                   20


<210> 16158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTGGATT

<400> 16158
ctttctgcaa ataaatgtgt                                                   20


<210> 16159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGTTT

<400> 16159
atttattttt ttctatgctt                                                   20


<210> 16160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTATGCTT

<400> 16160
ttaatttcat ttattttttt                                                   20


<210> 16161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTATGATT

<400> 16161
ggtttggagg ttgcagtcag                                                   20


<210> 16162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAGGTTT

<400> 16162
gggaagaaca cttgagccca                                                   20


<210> 16163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGCTT

<400> 16163
acttaacatt gtgggaaaat                                                   20


<210> 16164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGTTT

<400> 16164
acgttttaaa tatcaaatta                                                   20


<210> 16165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAACGTTT

<400> 16165
gaaattcaca ttttagataa                                                   20


<210> 16166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 16166
actgaccaaa gaagaactag                                                   20


<210> 16167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACCAGTTT

<400> 16167
atttctattc atttttgaaa                                                   20


<210> 16168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTATGTTT

<400> 16168
aaaaaatctc atttctaggc                                                   20


<210> 16169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGTTT

<400> 16169
gcagaggctg agcaggatag                                                   20


<210> 16170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAGGTTT

<400> 16170
aaaaatgtag agtattaata                                                   20


<210> 16171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGTTT

<400> 16171
acttgaatga atgaatgaat                                                   20


<210> 16172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGATGCTT

<400> 16172
cttggagtta ctaactgctc                                                   20


<210> 16173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGAGTTT

<400> 16173
atttttcgtt atacatactt                                                   20


<210> 16174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGTTT

<400> 16174
tgacgaagga aggtatgaaa                                                   20


<210> 16175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCTGATT

<400> 16175
tgatacagaa agatttccaa                                                   20


<210> 16176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAAGATT

<400> 16176
gctttataca tgctgataca                                                   20


<210> 16177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTAGCTT

<400> 16177
atgaagctgc tataaaaaga                                                   20


<210> 16178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGCTT

<400> 16178
actaatgaga agataattat                                                   20


<210> 16179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAAGTTT

<400> 16179
gtagaacaaa accctgtaac                                                   20


<210> 16180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTGGCTT

<400> 16180
ggaaaaataa ctaataagta                                                   20


<210> 16181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACCTGTTT

<400> 16181
ggttacaaat ggaacatttt                                                   20


<210> 16182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGAGATT

<400> 16182
gggtgtcatt tagcatgaaa                                                   20


<210> 16183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGGGATT

<400> 16183
gcttcttctg gtcattgtca                                                   20


<210> 16184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATGGCTT

<400> 16184
cgccttcctt tttgtccttt                                                   20


<210> 16185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCAAGCTT

<400> 16185
gaaagtgagc atcaagcaat                                                   20


<210> 16186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCCTGTTT

<400> 16186
tttcaaaagg tggcatcttt                                                   20


<210> 16187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTAGTTT

<400> 16187
aatataccaa taacctcctt                                                   20


<210> 16188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATGGATT

<400> 16188
gacacattgt ttggggagag                                                   20


<210> 16189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGTTT

<400> 16189
tgtgcaaaca atccctgaca                                                   20


<210> 16190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGTTT

<400> 16190
aaataaataa ataaataaat                                                   20


<210> 16191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACTGCTT

<400> 16191
tcaggaggct gaggcaggag                                                   20


<210> 16192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGTTT

<400> 16192
tttcggccgg gtgtggtggc                                                   20


<210> 16193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAAGTTT

<400> 16193
aactaaaatg ataagaatta                                                   20


<210> 16194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGCTT

<400> 16194
attcaattta attaaaatgt                                                   20


<210> 16195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGATT

<400> 16195
aaacacagga gccactggag                                                   20


<210> 16196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAGGTTT

<400> 16196
ataatatatc aatgtcatta                                                   20


<210> 16197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 16197
tagaagaaaa catgtgaagg                                                   20


<210> 16198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAGGTTT

<400> 16198
actgctagaa gaaaacatgt                                                   20


<210> 16199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACTGCTT

<400> 16199
ggataaaaat aaattcagat                                                   20


<210> 16200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGATT

<400> 16200
gtcatgtgga taaaaataaa                                                   20


<210> 16201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGTGCTT

<400> 16201
aggtattaaa aaaagagtca                                                   20


<210> 16202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGTTT

<400> 16202
gtgatattat acttggcata                                                   20


<210> 16203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCCTGTTT

<400> 16203
ctaaaatgag tagccagcct                                                   20


<210> 16204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGATT

<400> 16204
tttggtttca tatatattgt                                                   20


<210> 16205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGTTT

<400> 16205
caagtattta atgaaaagta                                                   20


<210> 16206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTAAGATT

<400> 16206
tacttatgaa ggatgcaatg                                                   20


<210> 16207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACATGATT

<400> 16207
attattttaa gaatttattt                                                   20


<210> 16208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACTGATT

<400> 16208
tactcttgtt gaagttatta                                                   20


<210> 16209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGATT

<400> 16209
ctataaaatg ccataaaatt                                                   20


<210> 16210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 16210
attatcgcat atacagctta                                                   20


<210> 16211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACAGCTT

<400> 16211
gaatataaaa ttatcgcata                                                   20


<210> 16212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGATT

<400> 16212
taaaataata aatataatat                                                   20


<210> 16213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGATT

<400> 16213
tgcctcggct tcccaaagtg                                                   20


<210> 16214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCGGCTT

<400> 16214
acctcaggtg atccgcctgc                                                   20


<210> 16215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGGGGTTT

<400> 16215
ttttgtattt ttagtagaga                                                   20


<210> 16216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGATT

<400> 16216
tgcctcagcc tcctgagtag                                                   20


<210> 16217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGAGTTT

<400> 16217
tttttttttt ttttttgaga                                                   20


<210> 16218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAAGATT

<400> 16218
ttcccagggt aatacacttc                                                   20


<210> 16219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAAGTTT

<400> 16219
agcaaatgtt gacactaatc                                                   20


<210> 16220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGGGATT

<400> 16220
aagtcttaac taacagagag                                                   20


<210> 16221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGATGTTT

<400> 16221
cactttctcc taaatcatgt                                                   20


<210> 16222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATGGCTT

<400> 16222
tttgtgttta ttggccaact                                                   20


<210> 16223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGTTT

<400> 16223
cataagattt tcgtaaggtt                                                   20


<210> 16224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAGGTTT

<400> 16224
tactccacat aagattttcg                                                   20


<210> 16225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGATT

<400> 16225
aggtaacaaa tatactccac                                                   20


<210> 16226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACATGTTT

<400> 16226
attttaaatt aaagccataa                                                   20


<210> 16227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGAGCTT

<400> 16227
tccggtttgc tatataagaa                                                   20


<210> 16228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCGGTTT

<400> 16228
aaaggattat cattttcagc                                                   20


<210> 16229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGATT

<400> 16229
ttttccacta aaataacctt                                                   20


<210> 16230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTAGCTT

<400> 16230
atattctcgt tcctaagaac                                                   20


<210> 16231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGCTT

<400> 16231
aggttttgta tatgcaatac                                                   20


<210> 16232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGTTT

<400> 16232
ttgaaagctc cctaagaaga                                                   20


<210> 16233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTGGTTT

<400> 16233
ttggtagaag gcaatgtagt                                                   20


<210> 16234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATGGATT

<400> 16234
tatccacatt tatcaaacct                                                   20


<210> 16235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGTTT

<400> 16235
ctttggttcc catgatattc                                                   20


<210> 16236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGATT

<400> 16236
tagagggtca tcattactgt                                                   20


<210> 16237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTGGATT

<400> 16237
catcagcagc tgttactgtg                                                   20


<210> 16238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGCTT

<400> 16238
tatttcatca gcagctgtta                                                   20


<210> 16239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGGGCTT

<400> 16239
cttattttga tattgaatta                                                   20


<210> 16240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCATGCTT

<400> 16240
tccaaagaat actttggcat                                                   20


<210> 16241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTAGTTT

<400> 16241
aaatcttatg agtagatgtc                                                   20


<210> 16242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGATT

<400> 16242
ttaccccctt cctttgctaa                                                   20


<210> 16243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACCAGATT

<400> 16243
tgttccttta gactcctcaa                                                   20


<210> 16244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGTTT

<400> 16244
tatgaacatg ttagtttgca                                                   20


<210> 16245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTAGTTT

<400> 16245
gaagtcatat ctatgaacat                                                   20


<210> 16246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCCAGATT

<400> 16246
cacatgagtt tcatcatatt                                                   20


<210> 16247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGAGTTT

<400> 16247
tgcattttaa acaatatcac                                                   20


<210> 16248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGATT

<400> 16248
cttcctattc atttgtgatc                                                   20


<210> 16249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 16249
cttggattct gagataaagc                                                   20


<210> 16250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTGGATT

<400> 16250
atataaattt gatcaggagt                                                   20


<210> 16251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTTGCTT

<400> 16251
tgaaccgttt ttgcctatgc                                                   20


<210> 16252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACCGTTT

<400> 16252
tttgtcattg aattgttgtg                                                   20


<210> 16253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGTTT

<400> 16253
gtgtttatac cacagatatt                                                   20


<210> 16254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGTGTTT

<400> 16254
gaaaactgaa gttttaaggt                                                   20


<210> 16255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGTTT

<400> 16255
aagagtttgt taccgaaaac                                                   20


<210> 16256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGTTT

<400> 16256
ttttgttaaa gtgttttcag                                                   20


<210> 16257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGTTT

<400> 16257
tttttcactc agttttgtta                                                   20


<210> 16258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCAGTTT

<400> 16258
gtaaagtcac ttatttttca                                                   20


<210> 16259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTAGATT

<400> 16259
tgatttctac tatttagaat                                                   20


<210> 16260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGATT

<400> 16260
ttctcaacgg tcaagtagat                                                   20


<210> 16261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGTTT

<400> 16261
tgagtaagaa agaaaagcta                                                   20


<210> 16262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGTGCTT

<400> 16262
tacaaggctt tgcacagaga                                                   20


<210> 16263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAGGCTT

<400> 16263
aatccacaca gaccatttta                                                   20


<210> 16264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAGGATT

<400> 16264
ctagatatga ttaaatcaaa                                                   20


<210> 16265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGATT

<400> 16265
ccttcatttt ctaatcctag                                                   20


<210> 16266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGTTT

<400> 16266
tcccatttca ttttgttttg                                                   20


<210> 16267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 16267
tttcaagaac tcccatttca                                                   20


<210> 16268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTGGTTT

<400> 16268
atacccattg tccccagaga                                                   20


<210> 16269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGCTT

<400> 16269
tcgtagactc taagagagtt                                                   20


<210> 16270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGAGTTT

<400> 16270
atataattcg tagactctaa                                                   20


<210> 16271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGTGATT

<400> 16271
cgtttaggtc tgtgattcat                                                   20


<210> 16272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGATT

<400> 16272
tctaactctg acgtttaggt                                                   20


<210> 16273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGACGTTT

<400> 16273
gaaatttaca gttctaactc                                                   20


<210> 16274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGAAGATT

<400> 16274
atgtgccaaa tctaatgtct                                                   20


<210> 16275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCGTGCTT

<400> 16275
ctcttttttt cttttgttga                                                   20


<210> 16276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACAGTTT

<400> 16276
agtagtgttc tttgatgcac                                                   20


<210> 16277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATGGATT

<400> 16277
gcaattattt tctcccatca                                                   20


<210> 16278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGATT

<400> 16278
atgttaatcc cttatcagat                                                   20


<210> 16279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTTGTTT

<400> 16279
cctttgttca tttttaatct                                                   20


<210> 16280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCTGCTT

<400> 16280
aaatcctttg ttcattttta                                                   20


<210> 16281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACTGATT

<400> 16281
atgttgagca tcttcccatg                                                   20


<210> 16282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGATT

<400> 16282
gaagtgatat tttattgtgg                                                   20


<210> 16283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGTTT

<400> 16283
agtgtgaagt gatattttat                                                   20


<210> 16284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGTTT

<400> 16284
caatttctcc acacccttgt                                                   20


<210> 16285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGTGTTT

<400> 16285
aattttttga ggaaccacca                                                   20


<210> 16286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGTTT

<400> 16286
attgctggat catgtgatat                                                   20


<210> 16287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGTTT

<400> 16287
ctacatgcgt cccttctatt                                                   20


<210> 16288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGATT

<400> 16288
ttgttttcac tttttggcta                                                   20


<210> 16289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTTGTTT

<400> 16289
catctgttga tagacatttg                                                   20


<210> 16290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 16290
ttattgtgca tttatacaca                                                   20


<210> 16291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGTTT

<400> 16291
ctggcttatt tcacttagca                                                   20


<210> 16292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTGGCTT

<400> 16292
atagcatttg tcttttcatg                                                   20


<210> 16293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACAGTTT

<400> 16293
cattttaacc atttcaaatg                                                   20


<210> 16294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGATT

<400> 16294
ggttgaccgg ttgctaactg                                                   20


<210> 16295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGATT

<400> 16295
gatcaatttt gatgtttatt                                                   20


<210> 16296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGATGTTT

<400> 16296
ttgtatattt cgatcaattt                                                   20


<210> 16297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 16297
ttacaattga gagtaacttt                                                   20


<210> 16298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAAGATT

<400> 16298
agggggcagg gctaataaga                                                   20


<210> 16299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTGGATT

<400> 16299
tctcttcctg tctgtaatgg                                                   20


<210> 16300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATGGATT

<400> 16300
tatattctct tcctgtctgt                                                   20


<210> 16301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACTGATT

<400> 16301
tgcatgtata tgtatttatg                                                   20


<210> 16302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGATT

<400> 16302
aataatgttt ttgtcttttt                                                   20


<210> 16303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGTTT

<400> 16303
ttctaatttc tatacaaaaa                                                   20


<210> 16304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAAGTTT

<400> 16304
aaaccagaaa aaaatgtttg                                                   20


<210> 16305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 16305
ggtaacataa aaccagaaaa                                                   20


<210> 16306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGGGATT

<400> 16306
gagggttttt cttgattttg                                                   20


<210> 16307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGATT

<400> 16307
aagcagaaga tgagggtttt                                                   20


<210> 16308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGGGTTT

<400> 16308
caagattgaa agcagaagat                                                   20


<210> 16309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCAAGATT

<400> 16309
gcatggttga aatacagaca                                                   20


<210> 16310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGCCGATT

<400> 16310
aacaacacat ggagatgtga                                                   20


<210> 16311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGTTT

<400> 16311
ttccctctct tccttcttca                                                   20


<210> 16312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAGGTTT

<400> 16312
caagttggta ttggtgccat                                                   20


<210> 16313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGGGATT

<400> 16313
ccaactgatt tatcttagcc                                                   20


<210> 16314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACTGATT

<400> 16314
aagttaaagc tgaaatttcc                                                   20


<210> 16315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGCTT

<400> 16315
aaaacttttg acagtgacag                                                   20


<210> 16316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGTTT

<400> 16316
tcaaagagat atatgcactt                                                   20


<210> 16317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAGGTTT

<400> 16317
tatcctctag actaagtggt                                                   20


<210> 16318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTAGCTT

<400> 16318
attttagtga tttgtggatt                                                   20


<210> 16319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGATT

<400> 16319
ctcaatctat tttagtgatt                                                   20


<210> 16320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGTGATT

<400> 16320
tgatacgtct caatctattt                                                   20


<210> 16321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGTTT

<400> 16321
gaaaactaat ttattttaca                                                   20


<210> 16322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACAGTTT

<400> 16322
ttgactttta agggttttaa                                                   20


<210> 16323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGGGTTT

<400> 16323
aatgcaagaa gttgactttt                                                   20


<210> 16324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGTTT

<400> 16324
aattaaaaaa atgtctagga                                                   20


<210> 16325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCCAGCTT

<400> 16325
tggtggccag cacctgtagt                                                   20


<210> 16326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTGGCTT

<400> 16326
gtctagggtg ggccaggcgc                                                   20


<210> 16327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGATT

<400> 16327
aaaggccttc cccaaggtag                                                   20


<210> 16328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 16328
actttgctat gattcgcata                                                   20


<210> 16329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTATGATT

<400> 16329
actactgtga cttgactttg                                                   20


<210> 16330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTTGTTT

<400> 16330
tgcatttaaa gtgtttttga                                                   20


<210> 16331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGTTT

<400> 16331
aaagagtacc tatgcattta                                                   20


<210> 16332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGAAGTTT

<400> 16332
gtcaaaatag agattttggt                                                   20


<210> 16333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGAGATT

<400> 16333
tatattgtgt taagtcaaaa                                                   20


<210> 16334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GACTGTTT

<400> 16334
acaaaaaaag aaagatggat                                                   20


<210> 16335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGTTT

<400> 16335
gctaccaagc attctatcaa                                                   20


<210> 16336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATACGTTT

<400> 16336
aaatcttata tattccaaga                                                   20


<210> 16337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCCGTTT

<400> 16337
tgttaaggga ttttcatatg                                                   20


<210> 16338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGGGATT

<400> 16338
tgctaactga gcagtttgtt                                                   20


<210> 16339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCAGTTT

<400> 16339
cgtctcctta atgctaactg                                                   20


<210> 16340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGTTT

<400> 16340
acaaggaaaa atacatacgg                                                   20


<210> 16341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGGGATT

<400> 16341
cacctcggcc ttctaaagtg                                                   20


<210> 16342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGGGTTT

<400> 16342
ttttgcagtt ttagtagaga                                                   20


<210> 16343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCAGTTT

<400> 16343
ccaccatgcc cggctaattt                                                   20


<210> 16344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGATT

<400> 16344
tgcctcagcc tcccaagtag                                                   20


<210> 16345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGATT

<400> 16345
aacctctgcc tcccagattc                                                   20


<210> 16346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCCAGATT

<400> 16346
gctcgctgca acctctgcct                                                   20


<210> 16347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCCGGTTT

<400> 16347
ttttacatag gtaaaggtgt                                                   20


<210> 16348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCAGGTTT

<400> 16348
aaggtacatt tgcaggatgt                                                   20


<210> 16349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAAGTTT

<400> 16349
cttttttttt ttttttttaa                                                   20


<210> 16350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGATT

<400> 16350
cgcctaggcc ccccaaagtg                                                   20


<210> 16351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAGGATT

<400> 16351
attttgtatt tttagtagag                                                   20


<210> 16352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCGGGATT

<400> 16352
tgcctcagcc tcccgagtag                                                   20


<210> 16353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCGAGTTT

<400> 16353
tctttttttt ttttttgaga                                                   20


<210> 16354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 16354
atatatgtat atacatcgta                                                   20


<210> 16355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGCTT

<400> 16355
tcaaatatta atttcttaaa                                                   20


<210> 16356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGAAGTTT

<400> 16356
ttcaaattag tatagtgaaa                                                   20


<210> 16357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 16357
ttataaagtt gaagtgatga                                                   20


<210> 16358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGTGATT

<400> 16358
ggtaagtgat gcctttatct                                                   20


<210> 16359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGCTT

<400> 16359
cattttgaat aggatgaatt                                                   20


<210> 16360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGATT

<400> 16360
attaaaattt atatttcata                                                   20


<210> 16361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCTGTTT

<400> 16361
gcctgggcaa taaaaggaaa                                                   20


<210> 16362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATTGCTT

<400> 16362
ttgggaggcc gaggctggag                                                   20


<210> 16363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGAGGATT

<400> 16363
cactttggga ggccgaggct                                                   20


<210> 16364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 16364
aaaacaggga aaaatgagaa                                                   20


<210> 16365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGTTT

<400> 16365
ttactagttg ctcctacact                                                   20


<210> 16366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGATGATT

<400> 16366
ccattatcta atgatgatga                                                   20


<210> 16367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGATT

<400> 16367
cgcctcgacc tcccaaagtg                                                   20


<210> 16368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGGAGTTT

<400> 16368
ttttgtattt ttagtagaga                                                   20


<210> 16369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGTTT

<400> 16369
cgcctaccac cgtgcccggc                                                   20


<210> 16370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGATT

<400> 16370
tccctgtatt atctgatttt                                                   20


<210> 16371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCTGATT

<400> 16371
acacctagac tccctgtatt                                                   20


<210> 16372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGATT

<400> 16372
taagtattaa aaacattccc                                                   20


<210> 16373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGATT

<400> 16373
gagcctctaa agaaagataa                                                   20


<210> 16374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 16374
tctcctacat ctcatcttcc                                                   20


<210> 16375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTAGGATT

<400> 16375
caataaagct ctaattgcac                                                   20


<210> 16376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAAGCTT

<400> 16376
atgtctcctt ggatttttta                                                   20


<210> 16377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTGGATT

<400> 16377
aaatttcttt aaaatgtctc                                                   20


<210> 16378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGATT

<400> 16378
taatttcctt gctattcatt                                                   20


<210> 16379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGATT

<400> 16379
aacacaggag atgaactatc                                                   20


<210> 16380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGTTT

<400> 16380
gtaagcaaaa aatatgttgt                                                   20


<210> 16381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAAGTTT

<400> 16381
gtaagcataa tctgccacag                                                   20


<210> 16382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGTTT

<400> 16382
cttggcagct aaaggtggaa                                                   20


<210> 16383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATGGCTT

<400> 16383
cctctgcctt gctggaagga                                                   20


<210> 16384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAGGATT

<400> 16384
ttgtataaaa atattttata                                                   20


<210> 16385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTAGATT

<400> 16385
ttcctttaga actgtgtaga                                                   20


<210> 16386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGGGATT

<400> 16386
attatttcac taattgtgag                                                   20


<210> 16387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACAGATT

<400> 16387
ttatgtagca aatggccagc                                                   20


<210> 16388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGATT

<400> 16388
caattaggtg acaaactgat                                                   20


<210> 16389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACTGATT

<400> 16389
tagctttcaa ttaggtgaca                                                   20


<210> 16390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGCTT

<400> 16390
tattaacatt tggttgaaaa                                                   20


<210> 16391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTAGTTT

<400> 16391
ttaaagatat taaacaaaca                                                   20


<210> 16392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTATGCTT

<400> 16392
ccccccttta tttttgcaga                                                   20


<210> 16393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGTGATT

<400> 16393
acacacacac acactttgta                                                   20


<210> 16394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGATT

<400> 16394
actgcaaact tcatgctcat                                                   20


<210> 16395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGGGCTT

<400> 16395
ggaaggttca gagaggcaat                                                   20


<210> 16396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGATGTTT

<400> 16396
ggtttccaca cggtctaaat                                                   20


<210> 16397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAGGTTT

<400> 16397
gatgaggcgg aggccataag                                                   20


<210> 16398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGCTT

<400> 16398
tattctttta aaataaacat                                                   20


<210> 16399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAGGTTT

<400> 16399
aatctaaaat gataaccttg                                                   20


<210> 16400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTGGATT

<400> 16400
aaaatatatt ttaagaaaaa                                                   20


<210> 16401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGATT

<400> 16401
taaccctgga aacatgaatt                                                   20


<210> 16402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATGGATT

<400> 16402
taaataataa aatacaaaaa                                                   20


<210> 16403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTAGCTT

<400> 16403
gactatgtct tcattgttga                                                   20


<210> 16404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACTGCTT

<400> 16404
ttggaacctt gtttctttca                                                   20


<210> 16405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTTGTTT

<400> 16405
tgttggtctt gatgttggaa                                                   20


<210> 16406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 16406
taaatctcaa ctcgaggttt                                                   20


<210> 16407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGAGGTTT

<400> 16407
ttaaacttta aatctcaact                                                   20


<210> 16408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCGTGCTT

<400> 16408
tcccaatgcc tgaactctat                                                   20


<210> 16409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATGGTTT

<400> 16409
gtaaatgcct ttcctcagca                                                   20


<210> 16410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGATT

<400> 16410
catccaagta ttgaaatcac                                                   20


<210> 16411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCAGATT

<400> 16411
gactttccct aaaactctgt                                                   20


<210> 16412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGTTT

<400> 16412
catgatcttg taaaagagct                                                   20


<210> 16413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGCTT

<400> 16413
gacaagtcat gatcttgtaa                                                   20


<210> 16414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAGGATT

<400> 16414
caaaagagtg tgaagtgcta                                                   20


<210> 16415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGAGTTT

<400> 16415
ttttactacc tgttgctgtg                                                   20


<210> 16416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTATGTTT

<400> 16416
gcccttctgt ggtaatgctt                                                   20


<210> 16417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGCTT

<400> 16417
tcatgggagc ccttctgtgg                                                   20


<210> 16418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGATGCTT

<400> 16418
ggctaggctc acagagtacc                                                   20


<210> 16419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTTGATT

<400> 16419
gtgactggat atatgatatg                                                   20


<210> 16420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGTTT

<400> 16420
tgcagttgtg ggactcagtg                                                   20


<210> 16421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGAGGTTT

<400> 16421
aattttgtag aggtttaaaa                                                   20


<210> 16422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAGGTTT

<400> 16422
caagtttttt aaaattttgt                                                   20


<210> 16423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAAGTTT

<400> 16423
aactgatagt ttggcttaag                                                   20


<210> 16424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGCTT

<400> 16424
tctatttagg caactgatag                                                   20


<210> 16425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATAGTTT

<400> 16425
tgccctctat ttaggcaact                                                   20


<210> 16426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTAGCTT

<400> 16426
caaattttca tgattgttag                                                   20


<210> 16427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGATT

<400> 16427
gatccctgtg tcgcaaattt                                                   20


<210> 16428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTAGTTT

<400> 16428
agatttttta aaaattattg                                                   20


<210> 16429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGATT

<400> 16429
tggtgagatt ttttaaaaat                                                   20


<210> 16430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGAGATT

<400> 16430
aattttttct tataattatg                                                   20


<210> 16431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGTTT

<400> 16431
agattttttc cactatttaa                                                   20


<210> 16432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGATT

<400> 16432
gttcatttta ttgcaaattc                                                   20


<210> 16433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGCTT

<400> 16433
atttaaatat attttataat                                                   20


<210> 16434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGATT

<400> 16434
cttcttccct gtagacaaga                                                   20


<210> 16435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATAGCTT

<400> 16435
aagtaagctt tcaaggaagt                                                   20


<210> 16436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTAAGCTT

<400> 16436
aagataaaag ccaaatcaaa                                                   20


<210> 16437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGGGGTTT

<400> 16437
aatttacatg agaaacttag                                                   20


<210> 16438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATAGATT

<400> 16438
tttttttaag ttggagcgtt                                                   20


<210> 16439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGTTT

<400> 16439
gtaaacattt cactcattat                                                   20


<210> 16440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGATT

<400> 16440
agaaacatta atgccagttt                                                   20


<210> 16441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCCAGTTT

<400> 16441
aagaaactag aaacattaat                                                   20


<210> 16442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGCAGATT

<400> 16442
gctctgcccc tatttctcag                                                   20


<210> 16443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACCAGCTT

<400> 16443
tgcaaagctg agcgtgcaga                                                   20


<210> 16444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGTTT

<400> 16444
ggtggtttac tgtcttttat                                                   20


<210> 16445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTGGTTT

<400> 16445
aaggaagggt agcaatgcct                                                   20


<210> 16446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGGGTTT

<400> 16446
tcctgtgcgg ttttgactct                                                   20


<210> 16447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCGGTTT

<400> 16447
cgatagctgg gcagctcctg                                                   20


<210> 16448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAAGCTT

<400> 16448
acctggaaag aagagagggg                                                   20


<210> 16449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCTGCTT

<400> 16449
caagtaagtg ccttttcttt                                                   20


<210> 16450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCCAGATT

<400> 16450
ggcccgcgcc ctctcctgga                                                   20


<210> 16451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCGGCTT

<400> 16451
ccagcgctcc agcggcggct                                                   20


<210> 16452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCTGCTT

<400> 16452
gccctggcag gaggggcgca                                                   20


<210> 16453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCCGATT

<400> 16453
agtgacttct cggaaacatt                                                   20


<210> 16454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGGAGTTT

<400> 16454
ggtccccacc tcctctgctc                                                   20


<210> 16455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGGGCTT

<400> 16455
cccagccact gccccagact                                                   20


<210> 16456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGATT

<400> 16456
cctggaagac gctgcaattc                                                   20


<210> 16457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGCTT

<400> 16457
tcttcgaaag aaaatgtatt                                                   20


<210> 16458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCTGATT

<400> 16458
ctttccccac ctaggacctc                                                   20


<210> 16459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCACGTTT

<400> 16459
ctggaaaagc agccttttcc                                                   20


<210> 16460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCCTGTTT

<400> 16460
ctttgagaaa gataattcaa                                                   20


<210> 16461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCTGTTT

<400> 16461
ttcttccctt ggtggaaatt                                                   20


<210> 16462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGATT

<400> 16462
caccctgccc tatggccatc                                                   20


<210> 16463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGTGTTT

<400> 16463
ataataaaag tgcccgtcac                                                   20


<210> 16464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGATT

<400> 16464
agggaaaagt agaccctggg                                                   20


<210> 16465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGATT

<400> 16465
gcagcaggga aaagtagacc                                                   20


<210> 16466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGTTT

<400> 16466
cattgcacag tctcagtcac                                                   20


<210> 16467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGCGATT

<400> 16467
accaccaatc agggaagaga                                                   20


<210> 16468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGCTT

<400> 16468
ttaaaaataa aagaatgtgg                                                   20


<210> 16469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGTTT

<400> 16469
ggaaatctct gtaccctccc                                                   20


<210> 16470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 16470
gtaagttcat taattttaac                                                   20


<210> 16471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAGGCTT

<400> 16471
accttcacaa agatgtttat                                                   20


<210> 16472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGTTT

<400> 16472
ccacacagta accttcacaa                                                   20


<210> 16473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCAGTTT

<400> 16473
agccactttg aggacagtgt                                                   20


<210> 16474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGCTT

<400> 16474
tgttaaccaa aatatacaaa                                                   20


<210> 16475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGATGCTT

<400> 16475
aatagtaagt tcttgttaat                                                   20


<210> 16476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGTTT

<400> 16476
ttttatcatt ttccaggatt                                                   20


<210> 16477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCAGGATT

<400> 16477
atttttggtt ttatcatttt                                                   20


<210> 16478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGTTT

<400> 16478
cagaccaaga ggattttatt                                                   20


<210> 16479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAGGATT

<400> 16479
gggatccctc agtcagacca                                                   20


<210> 16480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGCTT

<400> 16480
aaaataatga ataatatacc                                                   20


<210> 16481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGTTT

<400> 16481
aatttggaaa gatacttttt                                                   20


<210> 16482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGTGTTT

<400> 16482
ctacatctga cgctgtcatt                                                   20


<210> 16483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAGGCTT

<400> 16483
ttattggctt tttcaaccag                                                   20


<210> 16484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTGGCTT

<400> 16484
tgattaggaa cttattggtt                                                   20


<210> 16485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGATT

<400> 16485
ttacggaagg tcagttgtaa                                                   20


<210> 16486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATGGATT

<400> 16486
aattcttatt cctattctgg                                                   20


<210> 16487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACAGTTT

<400> 16487
tttgttcttc cagaaacttc                                                   20


<210> 16488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGTTT

<400> 16488
ttctattttc acaacagaat                                                   20


<210> 16489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTTGTTT

<400> 16489
ttaggaaacc tcttttcttc                                                   20


<210> 16490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCAGTTT

<400> 16490
aaacatttat ttttcttcac                                                   20


<210> 16491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGTTT

<400> 16491
tacaagggaa tgtcgataac                                                   20


<210> 16492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGTGTTT

<400> 16492
gttgcccaat gactgaaaac                                                   20


<210> 16493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGTTT

<400> 16493
atgtttccat cttcctgagc                                                   20


<210> 16494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGTTT

<400> 16494
aactcttatt ttctggctct                                                   20


<210> 16495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 16495
ctttctctgg cttagggtat                                                   20


<210> 16496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTGGCTT

<400> 16496
tgcatgactg tagttctttc                                                   20


<210> 16497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTAGGTTT

<400> 16497
tatgtagtag actataccat                                                   20


<210> 16498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAGGTTT

<400> 16498
tcagtacagt aacatgttgt                                                   20


<210> 16499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTATGATT

<400> 16499
tgtaactttt ctatgtttag                                                   20


<210> 16500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTATGTTT

<400> 16500
gtatttttac tgtaactttt                                                   20


<210> 16501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACAGATT

<400> 16501
tgcatatatg atggtggtcc                                                   20


<210> 16502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAAGATT

<400> 16502
aagaattttt aacctgctac                                                   20


<210> 16503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGTTT

<400> 16503
cagagtctac ccaatatctc                                                   20


<210> 16504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCATGATT

<400> 16504
gctaaggtaa tgtcggttat                                                   20


<210> 16505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGAAGATT

<400> 16505
gatcagtcgt tgtcaactgg                                                   20


<210> 16506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGTTT

<400> 16506
tgtcataact gtggaattag                                                   20


<210> 16507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAAGATT

<400> 16507
agaattatcc agctcaaata                                                   20


<210> 16508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCTGATT

<400> 16508
caggccttag agaaataaat                                                   20


<210> 16509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAAGTTT

<400> 16509
ttttaatgta gaatgtatat                                                   20


<210> 16510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCTGTTT

<400> 16510
tatttcctac ttgacattat                                                   20


<210> 16511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCCAGTTT

<400> 16511
taacttagtc cttcaaaaat                                                   20


<210> 16512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GACAGTTT

<400> 16512
ttttattttg tgagcagtgg                                                   20


<210> 16513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACAGATT

<400> 16513
aaactattga ggctgaagca                                                   20


<210> 16514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAAGCTT

<400> 16514
gctgacatgg tgtagggctg                                                   20


<210> 16515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGAGTTT

<400> 16515
acttgtagac agtaatagta                                                   20


<210> 16516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAGGATT

<400> 16516
agagtttgta aaatctttgc                                                   20


<210> 16517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGATT

<400> 16517
actctggcta ctgtactgag                                                   20


<210> 16518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATGGATT

<400> 16518
agatttggaa gtgaggcaag                                                   20


<210> 16519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATGGATT

<400> 16519
ataaagaggt taaaggtggt                                                   20


<210> 16520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTGGATT

<400> 16520
gaggttaaag gtggtaatgg                                                   20


<210> 16521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAGGATT

<400> 16521
taaatgcgga gggttaatga                                                   20


<210> 16522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTAGTTT

<400> 16522
gcggagggtt aatgaagagg                                                   20


<210> 16523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGGGATT

<400> 16523
agttgtccct tagtatctgc                                                   20


<210> 16524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTGGCTT

<400> 16524
tcccttagta tctgctgggg                                                   20


<210> 16525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGTGTTT

<400> 16525
aatctcttat acaaatggca                                                   20


<210> 16526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGCTT

<400> 16526
tcttatacaa atggcatagt                                                   20


<210> 16527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGTTT

<400> 16527
aacctacaca catcctccta                                                   20


<210> 16528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATGGATT

<400> 16528
cctacacatc acttcatttg                                                   20


<210> 16529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAAGTTT

<400> 16529
gtactcagca tatggaaaat                                                   20


<210> 16530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGGGCTT

<400> 16530
aaaattcaag ttttgccttt                                                   20


<210> 16531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGATT

<400> 16531
agttttgcct tttggggctt                                                   20


<210> 16532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGAGATT

<400> 16532
atatatatat atcttccacc                                                   20


<210> 16533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCCAGCTT

<400> 16533
tggtatatta ttatgacagc                                                   20


<210> 16534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGCTT

<400> 16534
gataatactc tggctcctgc                                                   20


<210> 16535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAACGTTT

<400> 16535
aactttttat gttccaaatg                                                   20


<210> 16536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGATT

<400> 16536
acgttttaga agacatttgc                                                   20


<210> 16537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGATT

<400> 16537
catgagtggg acaagtatac                                                   20


<210> 16538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAAGATT

<400> 16538
tttgactttg agaaaattac                                                   20


<210> 16539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGCTT

<400> 16539
acttaagatt gcccattttc                                                   20


<210> 16540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGTGCTT

<400> 16540
cttctgggta aaaatttgta                                                   20


<210> 16541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACACGATT

<400> 16541
taaggtgcac tgaatggtaa                                                   20


<210> 16542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGCTT

<400> 16542
ttgataagat aacaattaac                                                   20


<210> 16543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGTTT

<400> 16543
ccacagtctg tatgagccat                                                   20


<210> 16544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGTTT

<400> 16544
tggaaaacag gagcatgcat                                                   20


<210> 16545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCAGCTT

<400> 16545
taacaaatga tcacaaattt                                                   20


<210> 16546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGTTT

<400> 16546
aggagcctgg gtatagttat                                                   20


<210> 16547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTGGTTT

<400> 16547
gaaggaatta gtgtatcaca                                                   20


<210> 16548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 16548
agccataagt aaaagaatgt                                                   20


<210> 16549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGATT

<400> 16549
tttaaagcag cacatgcaaa                                                   20


<210> 16550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGTTT

<400> 16550
actgaactaa cttgaagaca                                                   20


<210> 16551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTAGATT

<400> 16551
aataactttt gctcagttct                                                   20


<210> 16552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGCTT

<400> 16552
ttttctgtat acttattgtg                                                   20


<210> 16553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 16553
tattgtgcat tgcttttatc                                                   20


<210> 16554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGATT

<400> 16554
tgtttctaaa gatatattta                                                   20


<210> 16555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGCTT

<400> 16555
taagtgtagc atgtgagctc                                                   20


<210> 16556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTTGTTT

<400> 16556
tgtagcatgt gagctctatt                                                   20


<210> 16557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGTTT

<400> 16557
tgtttataac tatcaattat                                                   20


<210> 16558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGAGATT

<400> 16558
gtaatttctc cctcccttga                                                   20


<210> 16559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGCTT

<400> 16559
accatgtatc ctgcagctca                                                   20


<210> 16560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGCTT

<400> 16560
ttatctacaa tgtgaaagaa                                                   20


<210> 16561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATGGATT

<400> 16561
atcacaatca cttatgttga                                                   20


<210> 16562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGTGATT

<400> 16562
aaatggatta cagtattatt                                                   20


<210> 16563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGATGCTT

<400> 16563
taatgaccat caacaggact                                                   20


<210> 16564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCTGATT

<400> 16564
cctttataaa tgtgcatatt                                                   20


<210> 16565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGTTT

<400> 16565
catatttcct gattttaata                                                   20


<210> 16566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGTTT

<400> 16566
actactaata taaattttca                                                   20


<210> 16567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGTTT

<400> 16567
attttcaatg tgttttcagt                                                   20


<210> 16568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGCTT

<400> 16568
tcattgtttt aatttcttca                                                   20


<210> 16569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATGGCTT

<400> 16569
attcagcaaa ctcatagggt                                                   20


<210> 16570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACAGCTT

<400> 16570
tatcacctct taagagctgg                                                   20


<210> 16571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGTTT

<400> 16571
gtagacatcg ctgtgtggct                                                   20


<210> 16572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGCTT

<400> 16572
gtggctagat gtttgcatat                                                   20


<210> 16573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGATT

<400> 16573
tccctttgca caaaccttga                                                   20


<210> 16574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTAGATT

<400> 16574
tcaagaaatt actttggaac                                                   20


<210> 16575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGTTT

<400> 16575
tctagattct ttgtccttgt                                                   20


<210> 16576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTAGATT

<400> 16576
tattttgtat aacttttatt                                                   20


<210> 16577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACAGCTT

<400> 16577
tttgtaaaga atcctatgta                                                   20


<210> 16578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGATT

<400> 16578
atttattttc atgaagcaat                                                   20


<210> 16579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATTGTTT

<400> 16579
attttcatga agcaattctt                                                   20


<210> 16580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACTGCTT

<400> 16580
tctctgaaat agctatttag                                                   20


<210> 16581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAAGATT

<400> 16581
aggttctcta attttcatcc                                                   20


<210> 16582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACCTGTTT

<400> 16582
tccgaaagat ttgtgttcaa                                                   20


<210> 16583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGAGTTT

<400> 16583
cagtaggaac acttgaagcc                                                   20


<210> 16584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTTGCTT

<400> 16584
ttgggaggct gaggcaggag                                                   20


<210> 16585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGTTT

<400> 16585
agcgagacct ggtcacttaa                                                   20


<210> 16586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACCTGTTT

<400> 16586
cttaaaaaag tttttagaaa                                                   20


<210> 16587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGCTT

<400> 16587
aaaaagtttt tagaaaacct                                                   20


<210> 16588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGCGATT

<400> 16588
attgttgggt gtaataagtt                                                   20


<210> 16589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAAGCTT

<400> 16589
aagagaggtc taattttact                                                   20


<210> 16590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGAGTTT

<400> 16590
ttcataatgc agttatattt                                                   20


<210> 16591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTAGATT

<400> 16591
atttgtgagt ttgaaataac                                                   20


<210> 16592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAGGCTT

<400> 16592
attatcaaaa cctatttcca                                                   20


<210> 16593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTAGATT

<400> 16593
tggtataaag aatctttagc                                                   20


<210> 16594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGAGTTT

<400> 16594
aaagaatctt tagccctaga                                                   20


<210> 16595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGTAGATT

<400> 16595
gccctagatt gagttttata                                                   20


<210> 16596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGTTT

<400> 16596
ctcattcttt aaccataaat                                                   20


<210> 16597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTACGTTT

<400> 16597
ataaatcttt gtttctatag                                                   20


<210> 16598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGCTT

<400> 16598
ttgccagaac aacaaaaaat                                                   20


<210> 16599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTTGTTT

<400> 16599
atggaaagca aattagtgaa                                                   20


<210> 16600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGCTT

<400> 16600
tagtgaaagt tgttttatat                                                   20


<210> 16601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGTGTTT

<400> 16601
cttttcaaat tactattaat                                                   20


<210> 16602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGCTT

<400> 16602
acagctaatg caaaatgaat                                                   20


<210> 16603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGATT

<400> 16603
attagaagcc catggtactg                                                   20


<210> 16604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGATT

<400> 16604
atacattgaa gtatatccaa                                                   20


<210> 16605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGCTT

<400> 16605
gttggcaaga atccctattt                                                   20


<210> 16606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACATGATT

<400> 16606
tgtgtaaagt ctgtcatatt                                                   20


<210> 16607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAAGCTT

<400> 16607
tctgtcatat tacatgattt                                                   20


<210> 16608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACGGGATT

<400> 16608
gatttgaaag cttgccaaac                                                   20


<210> 16609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAGGATT

<400> 16609
aacaactaac tgcatatcag                                                   20


<210> 16610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGCTT

<400> 16610
atcaggaagg atttcatcaa                                                   20


<210> 16611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGTTT

<400> 16611
aaagcaggaa aatttgacaa                                                   20


<210> 16612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGTTT

<400> 16612
ataacttttt tctcagttat                                                   20


<210> 16613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGATT

<400> 16613
aaagccaagg caaatacttt                                                   20


<210> 16614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGATT

<400> 16614
tttccaaata atagataaat                                                   20


<210> 16615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGTTT

<400> 16615
tagatttttc tgtatgcgtg                                                   20


<210> 16616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGTTT

<400> 16616
aaagatgaca aggcagatgt                                                   20


<210> 16617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGATT

<400> 16617
taaaagtttt ctacatggtc                                                   20


<210> 16618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTACGATT

<400> 16618
ataattccta cagagttctc                                                   20


<210> 16619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGATT

<400> 16619
cttcgagaat attttgataa                                                   20


<210> 16620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGTTT

<400> 16620
tttggcatag acttcctcaa                                                   20


<210> 16621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGCTT

<400> 16621
atcaaaaatg aagctctatt                                                   20


<210> 16622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTGGCTT

<400> 16622
cttgttcata tttctctttg                                                   20


<210> 16623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCTGTTT

<400> 16623
gaggtggtgg atgaagtggc                                                   20


<210> 16624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGTTT

<400> 16624
tgacagtagc agacacatcc                                                   20


<210> 16625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCCGTTT

<400> 16625
tagcagacac atcctcttgt                                                   20


<210> 16626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAGGATT

<400> 16626
tgggttcata ggacactttg                                                   20


<210> 16627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACACGCTT

<400> 16627
tctccccact ctcacccaaa                                                   20


<210> 16628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGGGTTT

<400> 16628
tggcaatgag ctggactttg                                                   20


<210> 16629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGAGTTT

<400> 16629
ccagggcagc tgcaaaatca                                                   20


<210> 16630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTGGCTT

<400> 16630
ctttttttgg gtcacagtcg                                                   20


<210> 16631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTAGGATT

<400> 16631
ctttgctcct ttgactagac                                                   20


<210> 16632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATACGTTT

<400> 16632
aacagggtag gggacacaaa                                                   20


<210> 16633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACAGTTT

<400> 16633
tacctgaaat gatgactcta                                                   20


<210> 16634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GACAGTTT

<400> 16634
ctcatttctt atgaattcaa                                                   20


<210> 16635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGGGGTTT

<400> 16635
ttttgtattt ttagtagaga                                                   20


<210> 16636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGATT

<400> 16636
cgcctcggcc tcccaaagtg                                                   20


<210> 16637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGATT

<400> 16637
actgaatgca attacttaaa                                                   20


<210> 16638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGTGTTT

<400> 16638
gccatttttt ccctccataa                                                   20


<210> 16639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGCTT

<400> 16639
aacaaatgta ttcatgttat                                                   20


<210> 16640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGATT

<400> 16640
aatctctgca tcccgggatc                                                   20


<210> 16641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGTTT

<400> 16641
ccaccacacc tggttaattt                                                   20


<210> 16642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GACGGTTT

<400> 16642
atttttgtgt ttttggtagg                                                   20


<210> 16643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGATT

<400> 16643
ggtctcaaac ttctgacttc                                                   20


<210> 16644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGATT

<400> 16644
cacctcggcc tcccaatgtg                                                   20


<210> 16645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATAGTTT

<400> 16645
tttactttat atgtcatgga                                                   20


<210> 16646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACTGTTT

<400> 16646
aaattgaaga ctagcattta                                                   20


<210> 16647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGTTT

<400> 16647
aacttgggtc aacagtatat                                                   20


<210> 16648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGTTT

<400> 16648
tgagtgctac cattcttctt                                                   20


<210> 16649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGTTT

<400> 16649
aaaataatcc acaattttcc                                                   20


<210> 16650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTTGTTT

<400> 16650
tgttattttg tatccttatt                                                   20


<210> 16651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGTTT

<400> 16651
ccttattggt tgtttttaac                                                   20


<210> 16652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGCTT

<400> 16652
ggttgttttt aacttctgtt                                                   20


<210> 16653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTAGTTT

<400> 16653
tttttaactt ctgtttttgg                                                   20


<210> 16654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGGGATT

<400> 16654
ggtatttgcc catgtgtcta                                                   20


<210> 16655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGATGATT

<400> 16655
gtctttcaac cttttattta                                                   20


<210> 16656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 16656
gattttttcc ccaaagaata                                                   20


<210> 16657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGCTT

<400> 16657
atttcttctt catttttttt                                                   20


<210> 16658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGTTT

<400> 16658
ttttttttgg ctttacaaat                                                   20


<210> 16659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGATT

<400> 16659
ctagaatctt tttttttaac                                                   20


<210> 16660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGATT

<400> 16660
tctttttttt taactttaga                                                   20


<210> 16661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGTTT

<400> 16661
gtaaattggt aattatacat                                                   20


<210> 16662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGAGCTT

<400> 16662
ttggactctc ttcaaaccca                                                   20


<210> 16663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACAGTTT

<400> 16663
ccactgagct tttatatttg                                                   20


<210> 16664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGTTT

<400> 16664
tttagaatca tttagactta                                                   20


<210> 16665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGATT

<400> 16665
attgatattt tccttgaatt                                                   20


<210> 16666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAAGCTT

<400> 16666
aaagtcttaa ttacaatgag                                                   20


<210> 16667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGCTT

<400> 16667
atgacaatcc tttcaattat                                                   20


<210> 16668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGTTT

<400> 16668
tttagctttc ttttatatcc                                                   20


<210> 16669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCAGATT

<400> 16669
tatttttatt gcaattgtga                                                   20


<210> 16670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTTGATT

<400> 16670
ctctaattga atttattttt                                                   20


<210> 16671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGTTT

<400> 16671
atattaagga tcatttactc                                                   20


<210> 16672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCTGTTT

<400> 16672
ttgtttttat atatgtacct                                                   20


<210> 16673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGCTT

<400> 16673
tttttttcct gacttaatag                                                   20


<210> 16674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGCTT

<400> 16674
tggtatgact tctggtgata                                                   20


<210> 16675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGATT

<400> 16675
ataatatgct tttccaaaat                                                   20


<210> 16676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGCTT

<400> 16676
tttccaaaat tattgatttt                                                   20


<210> 16677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGATT

<400> 16677
ctgttatgtg gcactcaatt                                                   20


<210> 16678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGATT

<400> 16678
gtcatgcaac cttgaacctt                                                   20


<210> 16679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGATT

<400> 16679
accttttcag attgataacc                                                   20


<210> 16680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGTTT

<400> 16680
ctctataatc tctctctctt                                                   20


<210> 16681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGATT

<400> 16681
gaacaccatg gctggttgag                                                   20


<210> 16682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGATT

<400> 16682
gtgctaaaac cagaagttat                                                   20


<210> 16683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTGGTTT

<400> 16683
gaagttattt cagattcaac                                                   20


<210> 16684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTAGTTT

<400> 16684
agctatatat aaacatggta                                                   20


<210> 16685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGCTT

<400> 16685
ccttctaata gatagaaata                                                   20


<210> 16686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 16686
ctgtagtatg agagacagat                                                   20


<210> 16687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGCTT

<400> 16687
gtatgagaga cagatatttg                                                   20


<210> 16688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAGGATT

<400> 16688
acagatattt gttttgcttt                                                   20


<210> 16689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGTTT

<400> 16689
tatacttcct tgagcataag                                                   20


<210> 16690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGCTT

<400> 16690
ttccttgagc ataagtgaag                                                   20


<210> 16691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCAGTTT

<400> 16691
agtagtagtg tctgagggag                                                   20


<210> 16692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGATT

<400> 16692
tagcacacat tctccagtga                                                   20


<210> 16693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGCTT

<400> 16693
agaaccatga tactaatatc                                                   20


<210> 16694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTTGATT

<400> 16694
ccatgatact aatatcaaag                                                   20


<210> 16695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTGGATT

<400> 16695
cactaggtca aatatacatc                                                   20


<210> 16696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTGGCTT

<400> 16696
tttttacccc tggtcgagga                                                   20


<210> 16697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGCTT

<400> 16697
ctggtcgagg aattggcttt                                                   20


<210> 16698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCCAGCTT

<400> 16698
gcttttgtgg cttcttggac                                                   20


<210> 16699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGATT

<400> 16699
aatcattgtc tacatctttc                                                   20


<210> 16700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAGGATT

<400> 16700
aatatttgta ttacatataa                                                   20


<210> 16701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGTTT

<400> 16701
tcttttggtg tgctaatcag                                                   20


<210> 16702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGATGATT

<400> 16702
aaagtaatga atatcttctt                                                   20


<210> 16703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGCTT

<400> 16703
cacaaaaaca agcaacgggg                                                   20


<210> 16704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATGGATT

<400> 16704
ttgtacaaaa attaactcaa                                                   20


<210> 16705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGCTT

<400> 16705
aatgggatct aattaaacta                                                   20


<210> 16706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAACGCTT

<400> 16706
gagaggatgt ggagaaatag                                                   20


<210> 16707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGATGATT

<400> 16707
aaccattgtg gaagacagtg                                                   20


<210> 16708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGGGATT

<400> 16708
tcattactgg gtatatactc                                                   20


<210> 16709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGGAGCTT

<400> 16709
ccaggggcag ttagggggtt                                                   20


<210> 16710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGGGATT

<400> 16710
tagggggttg ggagctttgg                                                   20


<210> 16711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTTGATT

<400> 16711
aatacctaat gtaaatgatg                                                   20


<210> 16712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCATGTTT

<400> 16712
tatacctatg taacaaacct                                                   20


<210> 16713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGATT

<400> 16713
ctaccttttt aattctaaat                                                   20


<210> 16714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATAGATT

<400> 16714
tggatgtcaa cattatcctt                                                   20


<210> 16715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGATT

<400> 16715
cccaaactga aggactttcc                                                   20


<210> 16716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAGGTTT

<400> 16716
taaataacat aacatctaaa                                                   20


<210> 16717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAAGCTT

<400> 16717
aaatcttaca aaggggggct                                                   20


<210> 16718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTAAGTTT

<400> 16718
gctaatttct taagttagct                                                   20


<210> 16719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACAGATT

<400> 16719
cttaagttag ctgtaagttt                                                   20


<210> 16720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAGGATT

<400> 16720
tataattaag aatttatttt                                                   20


<210> 16721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATGGTTT

<400> 16721
ggaattaaag atgacctggt                                                   20


<210> 16722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTGGATT

<400> 16722
ttatggtttc cctttattct                                                   20


<210> 16723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGCTT

<400> 16723
ttctcttgga tttggtaata                                                   20


<210> 16724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGTTT

<400> 16724
tcttatttac ttattttttt                                                   20


<210> 16725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGAAGCTT

<400> 16725
taattgtttg ctattgaatg                                                   20


<210> 16726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGTGTTT

<400> 16726
agacttccct ttctgcctta                                                   20


<210> 16727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGTTT

<400> 16727
gttgttgttg ttgttgttgt                                                   20


<210> 16728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGATT

<400> 16728
tgtctcagcc tcccaagtag                                                   20


<210> 16729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGGGTTT

<400> 16729
ttttgtattt ttagtagaga                                                   20


<210> 16730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTGGTTT

<400> 16730
ggtttcacca tgttggctgg                                                   20


<210> 16731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGATT

<400> 16731
agccttggcc tcccaaagtg                                                   20


<210> 16732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGTGTTT

<400> 16732
caccatatcc ggccacctta                                                   20


<210> 16733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGCTT

<400> 16733
gccaccttag agtgttttaa                                                   20


<210> 16734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGATT

<400> 16734
tttgaagaga aaatcaaagt                                                   20


<210> 16735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 16735
gagaaaatca aagtaataga                                                   20


<210> 16736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGAGATT

<400> 16736
aagaatggga taaaactaat                                                   20


<210> 16737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGGTGTTT

<400> 16737
ttcaatagag aaacttgcgt                                                   20


<210> 16738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 16738
tagagaaact tgcgtgggtg                                                   20


<210> 16739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGCTT

<400> 16739
gcgtgggtgt tttgttttcc                                                   20


<210> 16740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTAGTTT

<400> 16740
gaaggaattc tgtaagtcag                                                   20


<210> 16741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTAAGTTT

<400> 16741
gtcctttctt ttgtccttgg                                                   20


<210> 16742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGTTT

<400> 16742
tataagagta gtcactgcat                                                   20


<210> 16743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTATGTTT

<400> 16743
tgacttttgt tctaatagta                                                   20


<210> 16744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGATT

<400> 16744
tgttctaata gtagtatgtt                                                   20


<210> 16745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGCTT

<400> 16745
catgggtagt tgatagagcc                                                   20


<210> 16746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGGGTTT

<400> 16746
cattgcattg tggaaaagat                                                   20


<210> 16747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTGGTTT

<400> 16747
actgtgctgg tatcctgtta                                                   20


<210> 16748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGTTT

<400> 16748
ttcagtgtgc tgcactaggg                                                   20


<210> 16749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTATGATT

<400> 16749
atggagcact gaaagaacca                                                   20


<210> 16750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTAGATT

<400> 16750
caaacatagg aaaaggggac                                                   20


<210> 16751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCTGTTT

<400> 16751
ggaaaagggg acggtagatt                                                   20


<210> 16752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGCTGTTT

<400> 16752
gtcagtccat aaatcttggt                                                   20


<210> 16753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGAGATT

<400> 16753
agttactgac cctaaagaaa                                                   20


<210> 16754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGTTT

<400> 16754
attcaaaata attatcctaa                                                   20


<210> 16755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAGGATT

<400> 16755
attgaactaa aaaactccct                                                   20


<210> 16756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGCGATT

<400> 16756
aaccactgtg gaagtccgtg                                                   20


<210> 16757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGATT

<400> 16757
ccatgactgg gtatataccc                                                   20


<210> 16758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTATGTTT

<400> 16758
ctataaagac gcatgcacac                                                   20


<210> 16759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTGGATT

<400> 16759
caaatgtcca acaatgatag                                                   20


<210> 16760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGCTT

<400> 16760
cgggaggctg aggcagagag                                                   20


<210> 16761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGAAGTTT

<400> 16761
caaattgcca aaagtgaaag                                                   20


<210> 16762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCAGATT

<400> 16762
agagctctct taagatgaac                                                   20


<210> 16763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTAGATT

<400> 16763
tgctgaggga gttcatcacc                                                   20


<210> 16764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGTTT

<400> 16764
gaataactaa aattacaaaa                                                   20


<210> 16765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGATT

<400> 16765
tgtgagggag gtattaaaag                                                   20


<210> 16766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGATT

<400> 16766
taaaagtgaa gatttttgat                                                   20


<210> 16767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCAGCTT

<400> 16767
atgattgaag ttaagttgtt                                                   20


<210> 16768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGATT

<400> 16768
agtagactat tataagatat                                                   20


<210> 16769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGATT

<400> 16769
aatagtaagt cattacctac                                                   20


<210> 16770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATGGATT

<400> 16770
caatgattat ttcaaataca                                                   20


<210> 16771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATAGATT

<400> 16771
caaaagacct acaatggctg                                                   20


<210> 16772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTCGTTT

<400> 16772
gttatatgct gtctccagat                                                   20


<210> 16773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGATT

<400> 16773
tgctgtctcc agatactcgt                                                   20


<210> 16774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATAGTTT

<400> 16774
tcgtttcaga tttaagaaaa                                                   20


<210> 16775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATGGTTT

<400> 16775
tccttcagta tctacagggt                                                   20


<210> 16776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGATGCTT

<400> 16776
ccaagggata ccaaaattga                                                   20


<210> 16777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGATT

<400> 16777
aaaatttgac cctctgtatc                                                   20


<210> 16778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGTGTTT

<400> 16778
gatttcacat tccatgaata                                                   20


<210> 16779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGATT

<400> 16779
cctgtaatta tatcagccaa                                                   20


<210> 16780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGATT

<400> 16780
tatggaatct ataaacaaac                                                   20


<210> 16781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGTTT

<400> 16781
atagatcaca tatcaggtca                                                   20


<210> 16782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGTTT

<400> 16782
atcacatatc aggtcatgaa                                                   20


<210> 16783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGATT

<400> 16783
gaaatatctc atataaacaa                                                   20


<210> 16784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTGGTTT

<400> 16784
aaaagtcaac aaaactaaga                                                   20


<210> 16785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACTGATT

<400> 16785
aatgaaagag gagaatttac                                                   20


<210> 16786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GACGGCTT

<400> 16786
aaaagaaatg tacaggacca                                                   20


<210> 16787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACAGCTT

<400> 16787
acactgtaag aaaagaaaat                                                   20


<210> 16788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGAGGTTT

<400> 16788
ttcagcaaca ttgtggaata                                                   20


<210> 16789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGCTT

<400> 16789
gaaatgtatt tatttctaga                                                   20


<210> 16790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTGGTTT

<400> 16790
aaaatcatct tcataattgc                                                   20


<210> 16791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGAGCTT

<400> 16791
aacttttata ggccctgaca                                                   20


<210> 16792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTGGCTT

<400> 16792
ttataggccc tgacacagag                                                   20


<210> 16793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCATGCTT

<400> 16793
agagcttggc ttttagatca                                                   20


<210> 16794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGAGTTT

<400> 16794
gaatggcaga gataagccat                                                   20


<210> 16795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGGGGTTT

<400> 16795
ctcaagtaca aaaaacgatg                                                   20


<210> 16796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAAGCTT

<400> 16796
tgaactgcct gagcactctc                                                   20


<210> 16797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACACGTTT

<400> 16797
cccatggaaa ccattaggct                                                   20


<210> 16798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTGGCTT

<400> 16798
acattcccca cgccttcttc                                                   20


<210> 16799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGGGGTTT

<400> 16799
ttttgtattt ttagtagaga                                                   20


<210> 16800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGATT

<400> 16800
cgcctcggcc tcccaaagtg                                                   20


<210> 16801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTGGCTT

<400> 16801
tctaccacca agaacaggaa                                                   20


<210> 16802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTGGCTT

<400> 16802
aacaggaagg tggcttcttc                                                   20


<210> 16803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCAGTTT

<400> 16803
cttgctcctg acataattta                                                   20


<210> 16804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAGGCTT

<400> 16804
tatgcagttt cttattagag                                                   20


<210> 16805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAAGTTT

<400> 16805
atcacatgtt aggccaccaa                                                   20


<210> 16806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAAGATT

<400> 16806
aacaagtttt aacaaattta                                                   20


<210> 16807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTATGTTT

<400> 16807
gaagattaaa atcatatcga                                                   20


<210> 16808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGAGATT

<400> 16808
aacaacctaa tattacatct                                                   20


<210> 16809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTTGTTT

<400> 16809
aaacaaagca aatactaaaa                                                   20


<210> 16810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCATGATT

<400> 16810
cacatttaaa acatcattca                                                   20


<210> 16811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGGGATT

<400> 16811
acatcattca ccatgattac                                                   20


<210> 16812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGGAGCTT

<400> 16812
tatgcaaaaa ctgaaaagtt                                                   20


<210> 16813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCTGTTT

<400> 16813
aaagcaagaa ataaaattat                                                   20


<210> 16814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCAGTTT

<400> 16814
atacataaat tcagtaaagt                                                   20


<210> 16815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTTGATT

<400> 16815
tctgtacact gaaaactata                                                   20


<210> 16816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACAGATT

<400> 16816
ccatactacc caaaataatc                                                   20


<210> 16817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCAGTTT

<400> 16817
atccctatca aaattctaat                                                   20


<210> 16818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGATT

<400> 16818
aaacccaatt atttatagtc                                                   20


<210> 16819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGTTT

<400> 16819
attgggccct ttctcatacc                                                   20


<210> 16820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAGGATT

<400> 16820
ctgtatgaca tttatctggg                                                   20


<210> 16821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTGGATT

<400> 16821
caaaagacaa taagagacaa                                                   20


<210> 16822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATGGATT

<400> 16822
aacagagtgg agagagagat                                                   20


<210> 16823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCTGTTT

<400> 16823
gtgaaaatgt aaattagtac                                                   20


<210> 16824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCAGTTT

<400> 16824
taggttggtg caaatgtaat                                                   20


<210> 16825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATGGATT

<400> 16825
agtagaggaa taaatcttaa                                                   20


<210> 16826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAAGATT

<400> 16826
attcaggaca taggcatggg                                                   20


<210> 16827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGCTT

<400> 16827
aatgggatct aattaaacta                                                   20


<210> 16828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGAGTTT

<400> 16828
agaatctata aggaacttaa                                                   20


<210> 16829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGTTT

<400> 16829
ttataaagac acatgcacac                                                   20


<210> 16830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGATT

<400> 16830
ggaaaaataa ccaatgcata                                                   20


<210> 16831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACATGTTT

<400> 16831
ctgtacaaca aacccctatg                                                   20


<210> 16832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGCTT

<400> 16832
tatttcaaaa ttgctaaaag                                                   20


<210> 16833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGTTT

<400> 16833
agcgtgactg aaaatttcta                                                   20


<210> 16834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGTTT

<400> 16834
aatgtttatg tagatcaaaa                                                   20


<210> 16835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGATT

<400> 16835
aaaaatcaca tgatcatcag                                                   20


<210> 16836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAGGTTT

<400> 16836
tatagaagtt gctataactt                                                   20


<210> 16837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGTGTTT

<400> 16837
tgggaggtga gacctttaag                                                   20


<210> 16838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAGGATT

<400> 16838
aatgcattaa tgctgttatc                                                   20


<210> 16839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAGGTTT

<400> 16839
cctccagtac tgtgatccca                                                   20


<210> 16840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGTTT

<400> 16840
catcccaatc tgaaagaaaa                                                   20


<210> 16841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGCGTTT

<400> 16841
aatcaacata caaaaatcac                                                   20


<210> 16842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGCTT

<400> 16842
aaagaaataa aatacttagg                                                   20


<210> 16843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGGGCTT

<400> 16843
ctcactgcag cctcatactc                                                   20


<210> 16844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGCTT

<400> 16844
aggactatag gtgtgtgcca                                                   20


<210> 16845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGATT

<400> 16845
agccttagcc tcccgagttg                                                   20


<210> 16846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGATT

<400> 16846
atacacaaaa ataaactcaa                                                   20


<210> 16847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAAGCTT

<400> 16847
tgtagaagaa aacatagcag                                                   20


<210> 16848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGATT

<400> 16848
cttcatgata ctgttcttga                                                   20


<210> 16849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGCTT

<400> 16849
attgagacca tatcaaacta                                                   20


<210> 16850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGGAGCTT

<400> 16850
aatggcgtga acccgggagg                                                   20


<210> 16851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGTGATT

<400> 16851
catggaaaca gagagaagaa                                                   20


<210> 16852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGTTT

<400> 16852
gaattgctat tcaatgggaa                                                   20


<210> 16853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAAGTTT

<400> 16853
ttaagcaggt agatctcata                                                   20


<210> 16854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 16854
aagaaaagga taccactttc                                                   20


<210> 16855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGTTT

<400> 16855
ttaactaatt gaagtgttgg                                                   20


<210> 16856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTAGATT

<400> 16856
gtcagaaaat aaaagctata                                                   20


<210> 16857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGAGTTT

<400> 16857
ctggaagaat gataggggat                                                   20


<210> 16858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGATGCTT

<400> 16858
tgatagggga tatgagtttt                                                   20


<210> 16859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACTGTTT

<400> 16859
tttgatgctt ctaaatcagt                                                   20


<210> 16860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGAAGATT

<400> 16860
aagaataaca ttaacaagca                                                   20


<210> 16861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGCTGTTT

<400> 16861
attaaagtca attggatgtt                                                   20


<210> 16862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACACGCTT

<400> 16862
gctcatactg ctctttctag                                                   20


<210> 16863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGTGCTT

<400> 16863
aagactgagg aattacttgt                                                   20


<210> 16864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGCTT

<400> 16864
atattacatg tatgtatata                                                   20


<210> 16865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGATT

<400> 16865
ttgcaaatca caagcaatac                                                   20


<210> 16866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 16866
actgtagatt ctaccctcta                                                   20


<210> 16867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTAGATT

<400> 16867
tagtcatttt gtgcatcact                                                   20


<210> 16868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGATT

<400> 16868
taaatgagga tactatgtct                                                   20


<210> 16869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCTGCTT

<400> 16869
agtcttaata aacatcaatc                                                   20


<210> 16870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACGGCTT

<400> 16870
tgctattaaa aaaggtctaa                                                   20


<210> 16871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGTTT

<400> 16871
caattcattt gctcattcat                                                   20


<210> 16872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGCTT

<400> 16872
ctgactgtca tgtatatttt                                                   20


<210> 16873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGATT

<400> 16873
aatttttctt attgtattta                                                   20


<210> 16874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGAGTTT

<400> 16874
tttggggata gagcatagta                                                   20


<210> 16875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGATT

<400> 16875
gagactctgt aataatactt                                                   20


<210> 16876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTGGATT

<400> 16876
ttttgtgatt gatgttatgg                                                   20


<210> 16877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGAGATT

<400> 16877
atggcatgtc actataatgg                                                   20


<210> 16878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAGGCTT

<400> 16878
gcaataaaat atattttctt                                                   20


<210> 16879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGTTT

<400> 16879
agtgtgagag aatatatttc                                                   20


<210> 16880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAGGTTT

<400> 16880
atttctcttg ttttaagccc                                                   20


<210> 16881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGATT

<400> 16881
agaaactaat acagttgatg                                                   20


<210> 16882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAAGATT

<400> 16882
attaattaat taaaaatttc                                                   20


<210> 16883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGTTT

<400> 16883
aataaataac tacttataaa                                                   20


<210> 16884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGATT

<400> 16884
tgtgttttga ataaatagtg                                                   20


<210> 16885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGGGTTT

<400> 16885
tgatatattg ctcaaaacct                                                   20


<210> 16886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGTTT

<400> 16886
ccagaaccta ttatttagaa                                                   20


<210> 16887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGATT

<400> 16887
tgttttctgt gcaaaaatga                                                   20


<210> 16888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGCTGCTT

<400> 16888
agaggctata ttcatatttg                                                   20


<210> 16889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATGGTTT

<400> 16889
attcattatt ttctttttca                                                   20


<210> 16890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAGGATT

<400> 16890
cagtgctatc ctaggtaaac                                                   20


<210> 16891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAGGTTT

<400> 16891
ttaagaagcc atagcattgt                                                   20


<210> 16892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGGGCTT

<400> 16892
ataatcttca aataactaca                                                   20


<210> 16893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGATT

<400> 16893
acattttgcc atgtattttc                                                   20


<210> 16894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGTTT

<400> 16894
attacctagg gagtaatcat                                                   20


<210> 16895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGTGTTT

<400> 16895
atttcacata aactcatcca                                                   20


<210> 16896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCCTGCTT

<400> 16896
atgccagcct gcactaagtg                                                   20


<210> 16897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGATGATT

<400> 16897
aacactatgg agtaggcatt                                                   20


<210> 16898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATAGATT

<400> 16898
tagacattta ttagacaaat                                                   20


<210> 16899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGATT

<400> 16899
aaatgataga ttcattaaat                                                   20


<210> 16900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGAGCTT

<400> 16900
aatttgcccg aagtcagttg                                                   20


<210> 16901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGGGCTT

<400> 16901
tcattgtcta tgtgagtccc                                                   20


<210> 16902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGTTT

<400> 16902
tcccaagggc ttcatgaagt                                                   20


<210> 16903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAAGCTT

<400> 16903
gaaatcactg aaataaacta                                                   20


<210> 16904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGTTT

<400> 16904
aactaagaag cttttaaaaa                                                   20


<210> 16905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGAGTTT

<400> 16905
tattctaaaa tagccataaa                                                   20


<210> 16906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCTGTTT

<400> 16906
atagccataa acagagtttt                                                   20


<210> 16907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTAAGTTT

<400> 16907
acaattatta agtaatacta                                                   20


<210> 16908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGATT

<400> 16908
ttcaacatgt ccatttaatg                                                   20


<210> 16909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCATGCTT

<400> 16909
taactcaaat gcaacagaac                                                   20


<210> 16910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACGTGATT

<400> 16910
aacctccgcc tcccaggttc                                                   20


<210> 16911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTAGGATT

<400> 16911
tgcctcagcc tcccaagcag                                                   20


<210> 16912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGGGTTT

<400> 16912
ttttgtattt ttagtagaga                                                   20


<210> 16913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACTGTTT

<400> 16913
ctgcgcccgg ccaagactgg                                                   20


<210> 16914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAGGTTT

<400> 16914
gacattatca aagttcactt                                                   20


<210> 16915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAACGATT

<400> 16915
tcataagggc aaaacattcg                                                   20


<210> 16916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCATGATT

<400> 16916
agtattcaaa agaaagaaaa                                                   20


<210> 16917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAGGATT

<400> 16917
caaaagaaag aaaagcatga                                                   20


<210> 16918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGTTT

<400> 16918
catcaaacca accagccgac                                                   20


<210> 16919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCAGGCTT

<400> 16919
agacatgaac tctgtgatca                                                   20


<210> 16920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACATGATT

<400> 16920
gatcaccagg cttacaaatt                                                   20


<210> 16921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGCTT

<400> 16921
caaaataact aagataatat                                                   20


<210> 16922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGATT

<400> 16922
gatcctatta ttaccagcat                                                   20


<210> 16923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGATT

<400> 16923
tttttgagac attctccaca                                                   20


<210> 16924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATGGTTT

<400> 16924
aaaaggattg agaatcttta                                                   20


<210> 16925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGATT

<400> 16925
tctttaaatg gtttaaatcc                                                   20


<210> 16926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATCGTTT

<400> 16926
tggttctacg aaataagagc                                                   20


<210> 16927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACAGTTT

<400> 16927
cagttaagac aaaaattagg                                                   20


<210> 16928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGCTT

<400> 16928
ttctttaatc ctttctttat                                                   20


<210> 16929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACCAGTTT

<400> 16929
catttgtact gctattgatc                                                   20


<210> 16930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGTTT

<400> 16930
caccagtttg tctttgccac                                                   20


<210> 16931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGATT

<400> 16931
tcctgtggca tttaacactc                                                   20


<210> 16932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGCTT

<400> 16932
acctacctgt catcttacac                                                   20


<210> 16933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGATT

<400> 16933
ccattcaagt acaaatgtgt                                                   20


<210> 16934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGCTT

<400> 16934
atgtattaag caggttctca                                                   20


<210> 16935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAGGTTT

<400> 16935
ctaatcagat catctaggga                                                   20


<210> 16936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAGGCTT

<400> 16936
aaacattttt ataaatattt                                                   20


<210> 16937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGGGTTT

<400> 16937
acatttttac aaaaacaggc                                                   20


<210> 16938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGATT

<400> 16938
tgttgacctt tggtccagag                                                   20


<210> 16939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAGGTTT

<400> 16939
tttggagttc atggacctgt                                                   20


<210> 16940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCAGATT

<400> 16940
gaaagacaat tctaactttc                                                   20


<210> 16941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGATT

<400> 16941
tacagtctat gtgacctcaa                                                   20


<210> 16942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTATGTTT

<400> 16942
atttcctgct gccctcccta                                                   20


<210> 16943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTATGATT

<400> 16943
tgccttgaat gcctatctgc                                                   20


<210> 16944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGGGCTT

<400> 16944
atgcctatct gcctatgatt                                                   20


<210> 16945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGTTT

<400> 16945
ggtctatgta ccactgtact                                                   20


<210> 16946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGTGTTT

<400> 16946
cacaacacct gacacatagt                                                   20


<210> 16947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 16947
tgacacatag ttggtgttta                                                   20


<210> 16948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTGGCTT

<400> 16948
caaacagagt taaatagtgg                                                   20


<210> 16949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTGGTTT

<400> 16949
ctggcttaat cactgaagga                                                   20


<210> 16950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATAGATT

<400> 16950
gttttgtagg ggaaagttgt                                                   20


<210> 16951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGCTT

<400> 16951
gtagatagaa tatttttgaa                                                   20


<210> 16952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGAGATT

<400> 16952
acactggata attaaaatag                                                   20


<210> 16953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAGGTTT

<400> 16953
agcagagatt gcagtcataa                                                   20


<210> 16954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGATT

<400> 16954
taggtttgta gggataacag                                                   20


<210> 16955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCAAGTTT

<400> 16955
cacttgaggc tggttaaaac                                                   20


<210> 16956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGAGTTT

<400> 16956
caagtttctt atccccatcc                                                   20


<210> 16957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGCTT

<400> 16957
gtctggggtg agatccaaga                                                   20


<210> 16958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGCGATT

<400> 16958
aacctctgcc tcccgggttc                                                   20


<210> 16959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGGGTTT

<400> 16959
ttttgcattt ttagtagaga                                                   20


<210> 16960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGTTT

<400> 16960
atgatccgtc cgtcttttta                                                   20


<210> 16961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAGGATT

<400> 16961
ataagtaaaa tacaatataa                                                   20


<210> 16962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGTGTTT

<400> 16962
ttgagcctta aaggacagat                                                   20


<210> 16963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTGGTTT

<400> 16963
tccatgtgtg ttacaaagtt                                                   20


<210> 16964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTTGTTT

<400> 16964
ggtagttgtt attcattata                                                   20


<210> 16965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGAGCTT

<400> 16965
gtgcaaatta agtaaactct                                                   20


<210> 16966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGTTT

<400> 16966
attaagtaaa ctctctgagc                                                   20


<210> 16967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTAGTTT

<400> 16967
tttctaatgc tccttaccca                                                   20


<210> 16968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTTGATT

<400> 16968
aacacctgat ataagtaggt                                                   20


<210> 16969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGTTT

<400> 16969
tgagagatga tgttaggaac                                                   20


<210> 16970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGAAGATT

<400> 16970
acttggactt cctagcacag                                                   20


<210> 16971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGTTT

<400> 16971
gtcactcatt tggatcattc                                                   20


<210> 16972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCAGGATT

<400> 16972
tttgacaata ttagataaag                                                   20


<210> 16973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGATT

<400> 16973
attagataaa ggcaggatta                                                   20


<210> 16974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGTTT

<400> 16974
actcataatt tctacatacc                                                   20


<210> 16975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGTTT

<400> 16975
attaaaaaat aagaacatta                                                   20


<210> 16976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGGGATT

<400> 16976
cttaaagctc tcagtgtccg                                                   20


<210> 16977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGTGTTT

<400> 16977
gccaagatct gagtagccaa                                                   20


<210> 16978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGATGTTT

<400> 16978
gcctaaaaat agggtaagat                                                   20


<210> 16979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGATT

<400> 16979
gatggatgtt tctgtaagga                                                   20


<210> 16980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTTGTTT

<400> 16980
gaaataatgt aagcaaagta                                                   20


<210> 16981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGCTT

<400> 16981
tatttgaata gaaatcatgc                                                   20


<210> 16982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGCTT

<400> 16982
cttttcacac ttttgtaatc                                                   20


<210> 16983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGTGATT

<400> 16983
aactcaggtc aaaatgaagt                                                   20


<210> 16984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGATT

<400> 16984
ttaaaaaaca ttttgaagac                                                   20


<210> 16985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAAGATT

<400> 16985
tgagttgggg caaattctca                                                   20


<210> 16986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATTGCTT

<400> 16986
ttggggcaaa ttctcaacaa                                                   20


<210> 16987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGATT

<400> 16987
tgcttctgcc ctacaatttc                                                   20


<210> 16988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGTTT

<400> 16988
ttagcaccaa agatctacca                                                   20


<210> 16989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTGGCTT

<400> 16989
gaatgagagt agctgatctc                                                   20


<210> 16990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGCTT

<400> 16990
acaatcaata tagatataat                                                   20


<210> 16991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGTTT

<400> 16991
ccttagatct ggatctataa                                                   20


<210> 16992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGAGATT

<400> 16992
ttacgaataa gttagtgact                                                   20


<210> 16993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGTTT

<400> 16993
aaactgactg atgaagcggg                                                   20


<210> 16994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATGGCTT

<400> 16994
agatgtctca ctaaatgtaa                                                   20


<210> 16995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGTTT

<400> 16995
taatcagaaa attttttttt                                                   20


<210> 16996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGTTT

<400> 16996
tttttttttt aatgttttgc                                                   20


<210> 16997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGTTT

<400> 16997
ttaatgtttt gctgtggttt                                                   20


<210> 16998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGGGCTT

<400> 16998
tcatgaatgg aatatagagt                                                   20


<210> 16999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGGGTTT

<400> 16999
gtgagttaga tatcacaaga                                                   20


<210> 17000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCCAGTTT

<400> 17000
agagtgggtt tattataaaa                                                   20


<210> 17001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCCAGCTT

<400> 17001
ggacccttca ccttagactt                                                   20


<210> 17002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGAGTTT

<400> 17002
gttctccaag ccactgttaa                                                   20


<210> 17003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGTTT

<400> 17003
gcatattatt aagactatgg                                                   20


<210> 17004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACTGTTT

<400> 17004
tatacgcctg tactgaagaa                                                   20


<210> 17005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTAAGTTT

<400> 17005
gaagaacact gtttaatcaa                                                   20


<210> 17006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGGGCTT

<400> 17006
atatacaaca gaatcatctg                                                   20


<210> 17007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGATT

<400> 17007
atcatctgta gggcttgtta                                                   20


<210> 17008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGAGTTT

<400> 17008
tgatttgcca catccaaccc                                                   20


<210> 17009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGATT

<400> 17009
gccacatcca accccagagt                                                   20


<210> 17010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAACGTTT

<400> 17010
gagttctcac ctacatgtgc                                                   20


<210> 17011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGTTT

<400> 17011
cacctacatg tgccaacgtt                                                   20


<210> 17012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGTTT

<400> 17012
ttcaagaaca actgctgtag                                                   20


<210> 17013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGAGCTT

<400> 17013
ctgtcagcaa gaatattgtg                                                   20


<210> 17014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGCTT

<400> 17014
attgtgtgga gctttactct                                                   20


<210> 17015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTCGTTT

<400> 17015
ctgtgctttg cattatattt                                                   20


<210> 17016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTTGTTT

<400> 17016
taaataatat ttcaaattgg                                                   20


<210> 17017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCCTGATT

<400> 17017
caaattggag ttgtttatct                                                   20


<210> 17018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGATT

<400> 17018
gtgtatttgt gataatattt                                                   20


<210> 17019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACAGTTT

<400> 17019
gagagagacc ccgtcatatt                                                   20


<210> 17020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGATT

<400> 17020
aactagataa cttgatatat                                                   20


<210> 17021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGTTT

<400> 17021
tacatattat agaaaaaagt                                                   20


<210> 17022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGTGATT

<400> 17022
tttttaacat ttaatatgtt                                                   20


<210> 17023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGCGATT

<400> 17023
aacctctgcc taccgggttc                                                   20


<210> 17024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGATT

<400> 17024
tgcctcagcc tcctgagtag                                                   20


<210> 17025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGGGGTTT

<400> 17025
tttgtatttt ttagtagaga                                                   20


<210> 17026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGATT

<400> 17026
tgcctcggac tctcaaagtg                                                   20


<210> 17027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGTTT

<400> 17027
accgcgcctg gccagaagcc                                                   20


<210> 17028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGCTT

<400> 17028
ggccagaagc caaaagttta                                                   20


<210> 17029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCAGATT

<400> 17029
taatttggta acattttgca                                                   20


<210> 17030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGCTT

<400> 17030
tcagatttta ctatgtatga                                                   20


<210> 17031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGATT

<400> 17031
ctatgtatga tcatgcttac                                                   20


<210> 17032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GACTGATT

<400> 17032
aacaaatctc taaaaactat                                                   20


<210> 17033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGATGTTT

<400> 17033
aaaaactatg actgattata                                                   20


<210> 17034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAGGTTT

<400> 17034
ttcttcccta aacacaaagg                                                   20


<210> 17035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGGAGATT

<400> 17035
attctgagaa aaataagact                                                   20


<210> 17036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTAGTTT

<400> 17036
ataataatgg gtattgtacc                                                   20


<210> 17037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAAGATT

<400> 17037
ccttgatctc accgactatt                                                   20


<210> 17038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGTTT

<400> 17038
tagagacaat tgtgtctcat                                                   20


<210> 17039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGATT

<400> 17039
aagttaactt tgtatttgta                                                   20


<210> 17040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 17040
tatcatctcc tacttctaaa                                                   20


<210> 17041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAACGATT

<400> 17041
agaaataatt tacatttgtt                                                   20


<210> 17042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGCTT

<400> 17042
acctatagcc tgaaaatata                                                   20


<210> 17043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAGGTTT

<400> 17043
tgataatatg caatagtggt                                                   20


<210> 17044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGTTT

<400> 17044
caacaccagg cattggtgaa                                                   20


<210> 17045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAAGTTT

<400> 17045
aaagcctgtg gaaataatat                                                   20


<210> 17046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAAGCTT

<400> 17046
aagtttcaat catgcacaac                                                   20


<210> 17047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGATT

<400> 17047
aatcatgcac aacttaagct                                                   20


<210> 17048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTGGTTT

<400> 17048
atgggccagc tgacattttt                                                   20


<210> 17049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCTGATT

<400> 17049
acctgatcat ttccacctcc                                                   20


<210> 17050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGCTT

<400> 17050
gagcctgtct ttcagctctc                                                   20


<210> 17051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAAGATT

<400> 17051
taataacagc agcaggaaag                                                   20


<210> 17052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTAGCTT

<400> 17052
tttgctaaat gaatgactgc                                                   20


<210> 17053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGGTGCTT

<400> 17053
ataggcctat agaacacaga                                                   20


<210> 17054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAAGCTT

<400> 17054
ttcatccata tattatcctt                                                   20


<210> 17055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGGTGCTT

<400> 17055
ttctattctc tccattaatg                                                   20


<210> 17056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTATGCTT

<400> 17056
ctccattaat gcggtgcttc                                                   20


<210> 17057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGGGCTT

<400> 17057
taggtgagct ctatctaatg                                                   20


<210> 17058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTACGCTT

<400> 17058
agctctatct aatgtagggc                                                   20


<210> 17059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGATT

<400> 17059
aaggctcatt gagacactga                                                   20


<210> 17060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGATT

<400> 17060
acagtcatga acttgtgcca                                                   20


<210> 17061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGCTT

<400> 17061
cagattcttc ttattctacg                                                   20


<210> 17062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCAGTTT

<400> 17062
aatactctaa aattatcctt                                                   20


<210> 17063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGAGGCTT

<400> 17063
aatggaattg aagtgcagag                                                   20


<210> 17064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAGGATT

<400> 17064
cagagggagg cttctagccc                                                   20


<210> 17065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGGGCTT

<400> 17065
ttgaaataca aagacaagga                                                   20


<210> 17066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCCTGTTT

<400> 17066
ttagtcacaa ggaaaacgaa                                                   20


<210> 17067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTAGCTT

<400> 17067
agaattcagc ccacaggggt                                                   20


<210> 17068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCTGATT

<400> 17068
aatgacctta tgtgagctct                                                   20


<210> 17069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAACGCTT

<400> 17069
gctctatctg atttaggact                                                   20


<210> 17070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGTTT

<400> 17070
ttcagttacc actcatttat                                                   20


<210> 17071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGATT

<400> 17071
acagtgaaaa gatatggtga                                                   20


<210> 17072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTAGCTT

<400> 17072
cagtgatagc tctgtcattt                                                   20


<210> 17073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCCAGCTT

<400> 17073
aagcaacttt taaaactgta                                                   20


<210> 17074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTTGTTT

<400> 17074
aaaatatcat aatctcacag                                                   20


<210> 17075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAAGATT

<400> 17075
attaaatgag aaaatctaaa                                                   20


<210> 17076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAGGTTT

<400> 17076
acttcttttt aacttttatt                                                   20


<210> 17077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAGGTTT

<400> 17077
ttaggtttga gggtacatgt                                                   20


<210> 17078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGGGGTTT

<400> 17078
cataggtaaa cacgtgtcat                                                   20


<210> 17079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTAGTTT

<400> 17079
tttgctatac ttttaaaaaa                                                   20


<210> 17080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACCAGCTT

<400> 17080
caacctgtct aagtacaaac                                                   20


<210> 17081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGATT

<400> 17081
atctttccct tttcttcctc                                                   20


<210> 17082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCTGTTT

<400> 17082
tgccctcccc aaatgtcttc                                                   20


<210> 17083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGATT

<400> 17083
acattgcatg gtagacacta                                                   20


<210> 17084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGAGCTT

<400> 17084
atgactccag gtaaggaaaa                                                   20


<210> 17085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGTTT

<400> 17085
agagcttttc tgatcacatt                                                   20


<210> 17086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGTTT

<400> 17086
acctaggaca ttcctcaggg                                                   20


<210> 17087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTTGCTT

<400> 17087
gtctctggga caaagagcag                                                   20


<210> 17088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGCTT

<400> 17088
acaaagagca gggttgctta                                                   20


<210> 17089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATGGCTT

<400> 17089
ctagctagat ctgggctcct                                                   20


<210> 17090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTAGCTT

<400> 17090
acaattaaga aaaaggttca                                                   20


<210> 17091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCTGCTT

<400> 17091
tctctttcaa ctctcatgga                                                   20


<210> 17092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCTGTTT

<400> 17092
acttttatcc taaaactacc                                                   20


<210> 17093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGCTT

<400> 17093
ttcccttttt ataacacaca                                                   20


<210> 17094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTTGCTT

<400> 17094
caagatgctt cacaagctga                                                   20


<210> 17095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCAGTTT

<400> 17095
tcccaccaca cttgcagttc                                                   20


<210> 17096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCTGTTT

<400> 17096
ttaatttcct gaatatctga                                                   20


<210> 17097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTACGATT

<400> 17097
tgatgctgtt ttatgcctcc                                                   20


<210> 17098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTACGTTT

<400> 17098
tagaccctga aaagcaccat                                                   20


<210> 17099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGCTT

<400> 17099
agaactttgt cacatttaca                                                   20


<210> 17100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCTGCTT

<400> 17100
tctgcaagac tgactgttga                                                   20


<210> 17101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTAGTTT

<400> 17101
gctgcttgtt gtaacttgaa                                                   20


<210> 17102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGCTT

<400> 17102
aacttgaaat tagttttatc                                                   20


<210> 17103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGAGCTT

<400> 17103
aacgactgtt gctcgccagt                                                   20


<210> 17104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGCTT

<400> 17104
ctctctttgt tctacaggga                                                   20


<210> 17105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGTTT

<400> 17105
tgttctacag ggaaagtgct                                                   20


<210> 17106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCCTGTTT

<400> 17106
gtttatgcca cagactctct                                                   20


<210> 17107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGGGATT

<400> 17107
tttgtcattg gcactaatca                                                   20


<210> 17108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGCTT

<400> 17108
gagcaggatc atgaggacaa                                                   20


<210> 17109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCAGGTTT

<400> 17109
ctgtgttcaa caatcttgta                                                   20


<210> 17110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACCAGATT

<400> 17110
gcaggttttc ctgatgttcc                                                   20


<210> 17111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACTGCTT

<400> 17111
ttaatacatt atttaatgca                                                   20


<210> 17112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATAGATT

<400> 17112
cacctatact tgcaatttca                                                   20


<210> 17113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGATGTTT

<400> 17113
cttcatcttc taactttgca                                                   20


<210> 17114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTAGTTT

<400> 17114
tgttttctaa atagttgtta                                                   20


<210> 17115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGCTT

<400> 17115
ctaaatagtt gttagttagt                                                   20


<210> 17116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGATT

<400> 17116
ttaagttcaa aagaaactca                                                   20


<210> 17117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACTGTTT

<400> 17117
tgattagaag atccagatga                                                   20


<210> 17118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAGGTTT

<400> 17118
aaaattgtac ttaaaaatgg                                                   20


<210> 17119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACATGATT

<400> 17119
ttttatgtat tcacctctgt                                                   20


<210> 17120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAGGTTT

<400> 17120
ctttcctcag tgaatttatg                                                   20


<210> 17121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTGGCTT

<400> 17121
catggaagaa atcaatctca                                                   20


<210> 17122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAGGCTT

<400> 17122
cttgagaaag agagatcagt                                                   20


<210> 17123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGTTT

<400> 17123
gaatcaaaat atcagtaaaa                                                   20


<210> 17124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACCAGTTT

<400> 17124
tgttatgcat agaaatttaa                                                   20


<210> 17125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGAGCTT

<400> 17125
acaagaggca agggtgagag                                                   20


<210> 17126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCAGATT

<400> 17126
aggtgagctt agaaaaattg                                                   20


<210> 17127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGAGTTT

<400> 17127
aagcattggc ctttacctta                                                   20


<210> 17128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGCTT

<400> 17128
ttggccttta ccttaaggag                                                   20


<210> 17129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAAGTTT

<400> 17129
tagagaggag taggggtgaa                                                   20


<210> 17130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGATT

<400> 17130
gtttcatacc cagaaaacca                                                   20


<210> 17131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAAGATT

<400> 17131
tccagtatcc tgtctggagg                                                   20


<210> 17132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACAGATT

<400> 17132
tagttaggaa ctagagttgt                                                   20


<210> 17133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCAGGATT

<400> 17133
atatttggca gataaaatca                                                   20


<210> 17134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGTGATT

<400> 17134
cagataaaat cagcaggatt                                                   20


<210> 17135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATTGATT

<400> 17135
taaaatcagc aggatttggt                                                   20


<210> 17136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGATT

<400> 17136
ggaggagctg actcggcagg                                                   20


<210> 17137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGTTT

<400> 17137
atgattttga gatgcctgtg                                                   20


<210> 17138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGATT

<400> 17138
ttgtttaaat acagatatcc                                                   20


<210> 17139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACAGTTT

<400> 17139
catgtatctg ctgaagtcag                                                   20


<210> 17140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCTGCTT

<400> 17140
gttgttaaac tgtcagaaat                                                   20


<210> 17141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCCGTTT

<400> 17141
tactgtattt tatttgtcta                                                   20


<210> 17142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTGGATT

<400> 17142
ctggacggtg gtctattctc                                                   20


<210> 17143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTAGTTT

<400> 17143
gcatttagca atttcacatc                                                   20


<210> 17144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGAGCTT

<400> 17144
aatctccaag cactacaaat                                                   20


<210> 17145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGATT

<400> 17145
aagcactaca aatgagagct                                                   20


<210> 17146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGTTT

<400> 17146
agataaacag tcaaggtgta                                                   20


<210> 17147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGTTT

<400> 17147
atatcctttc attattgaaa                                                   20


<210> 17148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGATT

<400> 17148
ttcattattg aaattctgtt                                                   20


<210> 17149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGCTT

<400> 17149
ctgttttttg atttgcaaat                                                   20


<210> 17150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGCTT

<400> 17150
gaatgagtaa agttctgaca                                                   20


<210> 17151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTTGTTT

<400> 17151
agtcttcatg ctaaaactat                                                   20


<210> 17152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGTTT

<400> 17152
aataggttgc ctatacatgc                                                   20


<210> 17153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACCAGTTT

<400> 17153
ttttttattt tccttggaga                                                   20


<210> 17154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGTTT

<400> 17154
aaaagagaaa ccaaagagta                                                   20


<210> 17155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGATT

<400> 17155
acataagagg cccagaaaga                                                   20


<210> 17156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGTTT

<400> 17156
ttgaaaaatt ttaatcaatt                                                   20


<210> 17157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACCTGTTT

<400> 17157
atgggcagca cttttttgat                                                   20


<210> 17158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAAGTTT

<400> 17158
acttttttga tacctgtttc                                                   20


<210> 17159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGATT

<400> 17159
tttgaatttt agatatttct                                                   20


<210> 17160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGAGTTT

<400> 17160
atataattca ttaacaagta                                                   20


<210> 17161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 17161
gacaagatgc acctggtaga                                                   20


<210> 17162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGTTT

<400> 17162
atgttttgta atgaatcttt                                                   20


<210> 17163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGTGTTT

<400> 17163
ctatagaaat acagcaaaca                                                   20


<210> 17164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGTGTTT

<400> 17164
tccctctccc cctatgtctc                                                   20


<210> 17165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCTGTTT

<400> 17165
atcatgtata ttttatgtgt                                                   20


<210> 17166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGAAGTTT

<400> 17166
tgttcctgtt ttttctctct                                                   20


<210> 17167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGCTT

<400> 17167
gaagactcaa actgagtctg                                                   20


<210> 17168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGCTT

<400> 17168
gagtctgtaa tgcttgctct                                                   20


<210> 17169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTGGCTT

<400> 17169
gtactcatca tagtcctcta                                                   20


<210> 17170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTTGATT

<400> 17170
tggcttaata ggtcatttat                                                   20


<210> 17171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTTGATT

<400> 17171
ttatagttga tttttaaaag                                                   20


<210> 17172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATAGCTT

<400> 17172
aggtgaatgg aaaatctaca                                                   20


<210> 17173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGTGCTT

<400> 17173
tgaatttttt aatattaact                                                   20


<210> 17174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAAGATT

<400> 17174
gaaaattatc cctttggtta                                                   20


<210> 17175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGATT

<400> 17175
ggttaagaag attttgctct                                                   20


<210> 17176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGATT

<400> 17176
attgaaggga aacattattc                                                   20


<210> 17177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGTTT

<400> 17177
agtaaacttt caatctgaaa                                                   20


<210> 17178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGGGTTT

<400> 17178
agtttcataa atattgccct                                                   20


<210> 17179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGAGTTT

<400> 17179
tcagggttta ttacacctca                                                   20


<210> 17180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTGGTTT

<400> 17180
caagagtgat ggagcgcctg                                                   20


<210> 17181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGATT

<400> 17181
tttgtgcaaa ggtatatccc                                                   20


<210> 17182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTGGTTT

<400> 17182
agtaaatgct atttcttttg                                                   20


<210> 17183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGAGTTT

<400> 17183
tgcattacat aaagtctatg                                                   20


<210> 17184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGATT

<400> 17184
atcaatataa ttaatttaaa                                                   20


<210> 17185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAAGCTT

<400> 17185
tttaaaaatt gattatgaaa                                                   20


<210> 17186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGATT

<400> 17186
tacaaaacat tttgaaagga                                                   20


<210> 17187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGCTT

<400> 17187
acattttgaa aggaagatga                                                   20


<210> 17188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGCGATT

<400> 17188
aacctctgcc tcctgggttc                                                   20


<210> 17189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACGGGATT

<400> 17189
tttttgtatt tttagtagaa                                                   20


<210> 17190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCTGATT

<400> 17190
ttatttttcg ctaactctaa                                                   20


<210> 17191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATCGTTT

<400> 17191
tgtgagacta tgaacaacaa                                                   20


<210> 17192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTGGATT

<400> 17192
tcttcagtaa aaacatgcta                                                   20


<210> 17193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGATT

<400> 17193
gaaacattgc tctgaactgg                                                   20


<210> 17194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGATT

<400> 17194
caacttgtaa gtaaacatgt                                                   20


<210> 17195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCATGCTT

<400> 17195
gattcttcat tctgacaagc                                                   20


<210> 17196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGTTT

<400> 17196
tcatgtggaa actatgcatt                                                   20


<210> 17197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTGGATT

<400> 17197
taagctccca tcacctctca                                                   20


<210> 17198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGCTT

<400> 17198
gcagaaactc caagaaatct                                                   20


<210> 17199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAAGATT

<400> 17199
tgctattcgc ccttccactc                                                   20


<210> 17200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGAGATT

<400> 17200
cactcttaag attgcacatt                                                   20


<210> 17201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 17201
cactttttaa aaataatgtc                                                   20


<210> 17202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 17202
aaaataatgt catttgtttt                                                   20


<210> 17203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGTTT

<400> 17203
taatgtcatt tgttttattt                                                   20


<210> 17204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTGGATT

<400> 17204
gctcactgca acctctgcct                                                   20


<210> 17205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGATT

<400> 17205
tgcctcagcc tcacaagtag                                                   20


<210> 17206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGGGTTT

<400> 17206
tttttcattt tcagtaaaaa                                                   20


<210> 17207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTGGTTT

<400> 17207
ttctccatct attttggcct                                                   20


<210> 17208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCAGGCTT

<400> 17208
aagaaacgcc acctttatag                                                   20


<210> 17209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGTTT

<400> 17209
atctgacctg ctacatcttg                                                   20


<210> 17210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGTTT

<400> 17210
tatgtttctt cagcaagggg                                                   20


<210> 17211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 17211
cacacaggta tttaataatt                                                   20


<210> 17212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGATT

<400> 17212
tatttgttta ctggaataaa                                                   20


<210> 17213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGCTGCTT

<400> 17213
gttgaaaggc taagcaaatt                                                   20


<210> 17214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGTTT

<400> 17214
aagcccaggt tcattggaaa                                                   20


<210> 17215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCAGTTT

<400> 17215
aatatttctt ctatactggc                                                   20


<210> 17216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGATGTTT

<400> 17216
attcacaaaa gtattttcat                                                   20


<210> 17217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAGGATT

<400> 17217
aagtattttc attgatgttt                                                   20


<210> 17218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGTTT

<400> 17218
atagtattaa tactttctgt                                                   20


<210> 17219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAAGTTT

<400> 17219
ttaatacttt ctgtaagagt                                                   20


<210> 17220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGTTT

<400> 17220
taagtttttt gaagtcattt                                                   20


<210> 17221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTTGATT

<400> 17221
ttttttggtt tgaaacttta                                                   20


<210> 17222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGCTT

<400> 17222
acttttaaag gaaactgtgc                                                   20


<210> 17223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGCTT

<400> 17223
attgactgga tgtcgtacac                                                   20


<210> 17224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGTTT

<400> 17224
aagaaaatcc atgcactctt                                                   20


<210> 17225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGCTT

<400> 17225
atgtctttat tttccaatca                                                   20


<210> 17226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGATGATT

<400> 17226
cttggacact gaaagcaagt                                                   20


<210> 17227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGATT

<400> 17227
tgtgctatca taacttctgt                                                   20


<210> 17228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTAAGTTT

<400> 17228
ggaagatagg cactgtgcta                                                   20


<210> 17229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAAGATT

<400> 17229
acagatgaga tatctgaaga                                                   20


<210> 17230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGTTT

<400> 17230
ataagtcggc aaattagaac                                                   20


<210> 17231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAAGTTT

<400> 17231
aacatatgtt tatcaggctc                                                   20


<210> 17232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGCTT

<400> 17232
tattacattg cagccctact                                                   20


<210> 17233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAGGATT

<400> 17233
tcagacttta ccctagaggc                                                   20


<210> 17234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGGGCTT

<400> 17234
gtgtgcatgc aaatcctctt                                                   20


<210> 17235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGCTT

<400> 17235
tttaagggtc tctcaaagtc                                                   20


<210> 17236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGTTT

<400> 17236
gaggaagctg taaaccatac                                                   20


<210> 17237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 17237
agctgtaaac catactaaag                                                   20


<210> 17238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 17238
aaaccatact aaagttttgt                                                   20


<210> 17239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGCTT

<400> 17239
tactaaagtt ttgtttttgt                                                   20


<210> 17240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGTTT

<400> 17240
aaaaaaactt attaaacttg                                                   20


<210> 17241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATGGCTT

<400> 17241
ttaagagtca atagcacaga                                                   20


<210> 17242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGAGCTT

<400> 17242
caggcatgca tgaaacacct                                                   20


<210> 17243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGATT

<400> 17243
tcagaataag aaaagataac                                                   20


<210> 17244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACAGTTT

<400> 17244
gactgtagtc aacagtatca                                                   20


<210> 17245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTAGATT

<400> 17245
cagttttctg agagttagtg                                                   20


<210> 17246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGATT

<400> 17246
agttagtgag tagattccat                                                   20


<210> 17247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCATGCTT

<400> 17247
ctctaaaata agaagtagta                                                   20


<210> 17248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAAGCTT

<400> 17248
agtgccatag atgtggaaac                                                   20


<210> 17249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCTGCTT

<400> 17249
tcggaattca taggttcagc                                                   20


<210> 17250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGAGCTT

<400> 17250
atcaactgtg ctgcactctg                                                   20


<210> 17251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACCGGTTT

<400> 17251
gctgcactct gaggagcttg                                                   20


<210> 17252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGATT

<400> 17252
ctcatgcaaa gtattatgaa                                                   20


<210> 17253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGTTT

<400> 17253
ctgtaaaata ataaacttta                                                   20


<210> 17254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACGGTTT

<400> 17254
atcaagacca caaaatcaaa                                                   20


<210> 17255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAGGTTT

<400> 17255
tataagtgat cataacgcaa                                                   20


<210> 17256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGAGCTT

<400> 17256
gcaaataggt ttttctcacc                                                   20


<210> 17257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGATGTTT

<400> 17257
cagagcttta tgagtaacca                                                   20


<210> 17258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGTTT

<400> 17258
actctgtcaa atttcccaaa                                                   20


<210> 17259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGATT

<400> 17259
taaaatactt atttcagata                                                   20


<210> 17260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGTTT

<400> 17260
ttaatatgat agcccaatct                                                   20


<210> 17261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGAGATT

<400> 17261
caatctaaag gtttgacttt                                                   20


<210> 17262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGAGTTT

<400> 17262
gcattattcc caccaggtcc                                                   20


<210> 17263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACAGTTT

<400> 17263
accaggtcca ggagtttgat                                                   20


<210> 17264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACTGATT

<400> 17264
actcaaaaac atgttattta                                                   20


<210> 17265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTAGTTT

<400> 17265
aactgattga attcatctaa                                                   20


<210> 17266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAGGCTT

<400> 17266
atattctata aaactataga                                                   20


<210> 17267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGAGTTT

<400> 17267
tttaaagtat aaactataga                                                   20


<210> 17268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGTTT

<400> 17268
tagaatgagt tttaaaatat                                                   20


<210> 17269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACAGATT

<400> 17269
aaaatatata agttttaaaa                                                   20


<210> 17270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACAGTTT

<400> 17270
aagtaccata tttagaagac                                                   20


<210> 17271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATGGCTT

<400> 17271
atttagaaga ctacagtttt                                                   20


<210> 17272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGTTT

<400> 17272
ctgaaaaaag aattattggc                                                   20


<210> 17273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATGGTTT

<400> 17273
taacaatagg aaatagttat                                                   20


<210> 17274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGATT

<400> 17274
ctggtaacaa cttttaaata                                                   20


<210> 17275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTGGTTT

<400> 17275
agcatcttca aacatcaata                                                   20


<210> 17276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACTGTTT

<400> 17276
acatcaataa ttggttttct                                                   20


<210> 17277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAAGATT

<400> 17277
actgtttaag agagcattaa                                                   20


<210> 17278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTAGATT

<400> 17278
ttaacaaaga tttatgccaa                                                   20


<210> 17279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACGTGATT

<400> 17279
ttatgagcaa gtaaaaattc                                                   20


<210> 17280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCAGGTTT

<400> 17280
gttgaaactt tttttcatat                                                   20


<210> 17281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGTTT

<400> 17281
ctttttttca tatgcaggtt                                                   20


<210> 17282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGCTT

<400> 17282
ttttttaatg gtcaattgaa                                                   20


<210> 17283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGATT

<400> 17283
acagacaaat tattatggct                                                   20


<210> 17284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGTTT

<400> 17284
ctaatagatt cttagacatt                                                   20


<210> 17285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 17285
tccatactgt atataaaatt                                                   20


<210> 17286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCATGCTT

<400> 17286
ataaaattaa atgtttataa                                                   20


<210> 17287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGCTT

<400> 17287
aaatctatac ttgctacagt                                                   20


<210> 17288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCAGATT

<400> 17288
gctacagtat aagcttcttt                                                   20


<210> 17289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGTTT

<400> 17289
agaaaggctg atatatataa                                                   20


<210> 17290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGTTT

<400> 17290
catatttaag tactttgaat                                                   20


<210> 17291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGATT

<400> 17291
tcaattattt gtattatttt                                                   20


<210> 17292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGTTT

<400> 17292
tttctttaaa ctcaatcatc                                                   20


<210> 17293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGTTT

<400> 17293
ttaaactcaa tcatctgttg                                                   20


<210> 17294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGCTT

<400> 17294
ctatattaga gaagtgaaat                                                   20


<210> 17295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATGGATT

<400> 17295
aggaccttct gtaattttca                                                   20


<210> 17296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGATT

<400> 17296
cttctgtaat tttcacatgg                                                   20


<210> 17297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGTTT

<400> 17297
atattgactg tgccttctaa                                                   20


<210> 17298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTTGATT

<400> 17298
aaaagttccc tccactatct                                                   20


<210> 17299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGATT

<400> 17299
tagctgtgaa acaatcctta                                                   20


<210> 17300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGCTT

<400> 17300
actgaaaata tgtccaaatt                                                   20


<210> 17301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATGGTTT

<400> 17301
ttaaaagctt tattattctt                                                   20


<210> 17302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGATT

<400> 17302
attattcttc atggttttcc                                                   20


<210> 17303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGTTT

<400> 17303
tccctttgat tgccttgaag                                                   20


<210> 17304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACTGCTT

<400> 17304
tgaagctgtg ttttctacta                                                   20


<210> 17305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGATT

<400> 17305
acaaaaacct tactcaaaga                                                   20


<210> 17306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACTGTTT

<400> 17306
catttcaagt acatactata                                                   20


<210> 17307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGCTT

<400> 17307
tcaagtacat actataaact                                                   20


<210> 17308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTAGTTT

<400> 17308
agcaagaaag acattttaaa                                                   20


<210> 17309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGTTT

<400> 17309
tccatctttt aatttaattg                                                   20


<210> 17310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCAAGTTT

<400> 17310
gcataagagt ccaatatttt                                                   20


<210> 17311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGTTT

<400> 17311
cattatgtta caggacaact                                                   20


<210> 17312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGAGTTT

<400> 17312
atgtgaacat tatcctctta                                                   20


<210> 17313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGTGCTT

<400> 17313
aatattattg atattactat                                                   20


<210> 17314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACATGATT

<400> 17314
gagtgtaatc acatttctta                                                   20


<210> 17315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGATT

<400> 17315
aatcacattt cttaacatga                                                   20


<210> 17316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAAGATT

<400> 17316
tttttttgat atgaaatttc                                                   20


<210> 17317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTAAGTTT

<400> 17317
actgtatttt cttctgttgt                                                   20


<210> 17318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCAGTTT

<400> 17318
cactaattta gcagaaaatt                                                   20


<210> 17319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGTGATT

<400> 17319
agagaaattc agaataaaac                                                   20


<210> 17320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACAGATT

<400> 17320
tgtaagaagg ctagactggc                                                   20


<210> 17321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACTGTTT

<400> 17321
gctctgtcac agaactgcta                                                   20


<210> 17322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCCAGCTT

<400> 17322
taaacaattt tgctatttat                                                   20


<210> 17323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAGGATT

<400> 17323
aaatgcaaca agtaggtaaa                                                   20


<210> 17324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAAGCTT

<400> 17324
caaagtgtag atacgcagac                                                   20


<210> 17325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTAGCTT

<400> 17325
ttttaatgaa tggaataatt                                                   20


<210> 17326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGATT

<400> 17326
aattactagc tttttaaaca                                                   20


<210> 17327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGCAGCTT

<400> 17327
ataactatat cctttatgta                                                   20


<210> 17328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGTTT

<400> 17328
aagtcattct taactgaata                                                   20


<210> 17329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACAGCTT

<400> 17329
acatgtacct catcttttct                                                   20


<210> 17330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGTTT

<400> 17330
aattcaaaac atatatatgc                                                   20


<210> 17331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGCTT

<400> 17331
catgtatata tatttctaga                                                   20


<210> 17332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGTTT

<400> 17332
aaatagcttt ctcaaaaatt                                                   20


<210> 17333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGTTT

<400> 17333
ttcaccatat tctggaataa                                                   20


<210> 17334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGTTT

<400> 17334
aaggtgtgtc aatttcagga                                                   20


<210> 17335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGCTT

<400> 17335
gtgtcaattt caggataaag                                                   20


<210> 17336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTAGATT

<400> 17336
cagagaaatt caaaatatga                                                   20


<210> 17337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAAGATT

<400> 17337
aactagatta taaaaaggag                                                   20


<210> 17338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGAGATT

<400> 17338
ggagtcaaga ttcttattgg                                                   20


<210> 17339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAGGATT

<400> 17339
gttctatgtg ttattgatag                                                   20


<210> 17340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTAGTTT

<400> 17340
aatatgctct atctaaacct                                                   20


<210> 17341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCTGATT

<400> 17341
ctcttagttt ctagagactg                                                   20


<210> 17342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTTGATT

<400> 17342
aaatcaaatg ttaattactg                                                   20


<210> 17343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAAGTTT

<400> 17343
aaaccatttc aaaatgtatt                                                   20


<210> 17344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGCTT

<400> 17344
ttatactaga agcagggtac                                                   20


<210> 17345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGCTT

<400> 17345
ctaagaaagc atgagtctca                                                   20


<210> 17346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGAGATT

<400> 17346
tacaatgatc ttttcctgct                                                   20


<210> 17347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGAGTTT

<400> 17347
acacttcttc cacaattttt                                                   20


<210> 17348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGATT

<400> 17348
tacatctctc catattttta                                                   20


<210> 17349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAGGTTT

<400> 17349
aatcaggaag ggaagttgat                                                   20


<210> 17350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGCTT

<400> 17350
atagaggttt tcaaattaaa                                                   20


<210> 17351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGTTT

<400> 17351
tttatctatt gaacaactgt                                                   20


<210> 17352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGTTT

<400> 17352
tcttgcagtg ggtcaggcag                                                   20


<210> 17353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTATGATT

<400> 17353
acattgaaaa aatatcgtat                                                   20


<210> 17354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGTTT

<400> 17354
agagctgcat ccttgactga                                                   20


<210> 17355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGTTT

<400> 17355
ttagaaatgc agcatgatga                                                   20


<210> 17356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGTTT

<400> 17356
tgatgaaaga gtttagtcaa                                                   20


<210> 17357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 17357
gtttagtcaa ctgtgtttta                                                   20


<210> 17358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTAAGATT

<400> 17358
aatatatttg aatcacagta                                                   20


<210> 17359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGTTT

<400> 17359
aatactataa tgtgctaatg                                                   20


<210> 17360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGATT

<400> 17360
tgcaagcaac atttaaatat                                                   20


<210> 17361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCAGCTT

<400> 17361
gtgaggtggc agtaagagta                                                   20


<210> 17362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGATT

<400> 17362
catattctaa aattagcatt                                                   20


<210> 17363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGTTT

<400> 17363
taaacagcat tgcaaaaaag                                                   20


<210> 17364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGATT

<400> 17364
aaaatataaa gaataagaca                                                   20


<210> 17365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGTTT

<400> 17365
aatatgtcag acaaatattt                                                   20


<210> 17366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAAGATT

<400> 17366
aaacaaatcc aatgaagatg                                                   20


<210> 17367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGTGCTT

<400> 17367
ctaagtgcaa ttctacagaa                                                   20


<210> 17368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGATT

<400> 17368
tcaaagtcaa atgcattttt                                                   20


<210> 17369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGATT

<400> 17369
agcagaaggt aaatctaaaa                                                   20


<210> 17370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGCTT

<400> 17370
gtgaatcagg tgaacaatat                                                   20


<210> 17371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGAGATT

<400> 17371
atgaatgctt gttcctctgc                                                   20


<210> 17372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTAGTTT

<400> 17372
actcaatgca tcctcaatgg                                                   20


<210> 17373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACGGATT

<400> 17373
ggactagttt agtgtcctgt                                                   20


<210> 17374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGCTT

<400> 17374
gtttagtgtc ctgttacgga                                                   20


<210> 17375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGCTT

<400> 17375
gtgtcctgtt acggattgtg                                                   20


<210> 17376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGTTT

<400> 17376
ccctttacct ttgaagtaca                                                   20


<210> 17377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGTTT

<400> 17377
gaagtacatg aagtttttag                                                   20


<210> 17378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGATT

<400> 17378
aatatttatg taattaagaa                                                   20


<210> 17379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGTTT

<400> 17379
ataagattat acaggtagaa                                                   20


<210> 17380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTAGTTT

<400> 17380
atgttgagcc acatgaaatt                                                   20


<210> 17381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCAGATT

<400> 17381
cacatgaaat ttctagtttt                                                   20


<210> 17382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGTTT

<400> 17382
agattaaaaa tggttggata                                                   20


<210> 17383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 17383
ttcaataagt aaaaattaac                                                   20


<210> 17384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGTTT

<400> 17384
ttttttggta attttataca                                                   20


<210> 17385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGATT

<400> 17385
aaggtatctt accaagagaa                                                   20


<210> 17386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAAGTTT

<400> 17386
agttggataa ggatctctgg                                                   20


<210> 17387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGCTT

<400> 17387
gcaagtggga tagtcattac                                                   20


<210> 17388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGATT

<400> 17388
tatagaagaa aaaacacatg                                                   20


<210> 17389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGATGTTT

<400> 17389
cacgtggact gctgatctgt                                                   20


<210> 17390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGGGATT

<400> 17390
aaaacacaca cacaaaaaaa                                                   20


<210> 17391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAGGTTT

<400> 17391
cccatgtacc cttaagtaaa                                                   20


<210> 17392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGATT

<400> 17392
gtgtagaaaa aattatgcca                                                   20


<210> 17393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGCTT

<400> 17393
ataataagtc atgacaaagg                                                   20


<210> 17394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAGGTTT

<400> 17394
gaacctcata gttacctcag                                                   20


<210> 17395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGAGTTT

<400> 17395
agaacttgaa tttggtctag                                                   20


<210> 17396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCAGTTT

<400> 17396
aaatatattc tagaagtaaa                                                   20


<210> 17397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATAGTTT

<400> 17397
ttcaataaag aagggaataa                                                   20


<210> 17398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTGGATT

<400> 17398
acctaatcag tcagcattaa                                                   20


<210> 17399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGATT

<400> 17399
cctttctatg gcatgtagta                                                   20


<210> 17400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACAGCTT

<400> 17400
atggcatgta gtataatgat                                                   20


<210> 17401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGGGTTT

<400> 17401
gtagtataat gattacagct                                                   20


<210> 17402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCGTGCTT

<400> 17402
cattttatcc gtgtgtgtgt                                                   20


<210> 17403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGTTT

<400> 17403
cttttgcatc cacctctcaa                                                   20


<210> 17404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCTGCTT

<400> 17404
gctctaaggc actgtccaca                                                   20


<210> 17405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGTGCTT

<400> 17405
gccttatcgt ggcagaaggg                                                   20


<210> 17406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGCTT

<400> 17406
ggagaagaaa ggcctgaccc                                                   20


<210> 17407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGTTT

<400> 17407
agaaaggcct gaccctcttg                                                   20


<210> 17408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTACGTTT

<400> 17408
tgcctcactt tttacagatg                                                   20


<210> 17409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCAGATT

<400> 17409
gaaaacactt ctcagtaaat                                                   20


<210> 17410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAGGATT

<400> 17410
gtaaatctca gatttctctc                                                   20


<210> 17411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTGGTTT

<400> 17411
tctcagattt ctctctcagg                                                   20


<210> 17412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCGTGATT

<400> 17412
gaactgaccc ctacacaatc                                                   20


<210> 17413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAAGATT

<400> 17413
ctctgacttt tcttctttcc                                                   20


<210> 17414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCATGTTT

<400> 17414
atgttgaagt cctaaccctg                                                   20


<210> 17415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGAGATT

<400> 17415
aaactacgtg agtaccgggc                                                   20


<210> 17416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAGGATT

<400> 17416
gatgatgcag ctgcaagctg                                                   20


<210> 17417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTTGATT

<400> 17417
aaatcatggc cttgctcaga                                                   20


<210> 17418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGAGTTT

<400> 17418
atttctgttg ttgtaagcca                                                   20


<210> 17419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGTGCTT

<400> 17419
tccctcagca attcttagca                                                   20


<210> 17420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAGGCTT

<400> 17420
ggtgcatttc atacttcctt                                                   20


<210> 17421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGTTT

<400> 17421
aagcctgtgt agtgtgttgt                                                   20


<210> 17422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGTGCTT

<400> 17422
gtgtgttgtt aatgtttgga                                                   20


<210> 17423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGGGCTT

<400> 17423
taatgtttgg agtgtgcttg                                                   20


<210> 17424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGATT

<400> 17424
ttgagataac agcatgtctt                                                   20


<210> 17425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 17425
agtgctattg ttctatttcc                                                   20


<210> 17426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACTGTTT

<400> 17426
atttccattt gtttcctcag                                                   20


<210> 17427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACCGTTT

<400> 17427
ctgtttaaga tatttgacta                                                   20


<210> 17428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGTTT

<400> 17428
ttaagatatt tgactaaacc                                                   20


<210> 17429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAGGTTT

<400> 17429
tctttggtta ttttctgata                                                   20


<210> 17430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGATT

<400> 17430
agaggtttta ctgtaaaata                                                   20


<210> 17431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGATT

<400> 17431
ttttactgta aaatattttg                                                   20


<210> 17432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGGGTTT

<400> 17432
ggatgctagg tcataaaaga                                                   20


<210> 17433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGATGTTT

<400> 17433
ggagagatat caaaggtcag                                                   20


<210> 17434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGGGATT

<400> 17434
aaacctgaat ccaagtaagc                                                   20


<210> 17435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATAGTTT

<400> 17435
catatttatg gggtacatgt                                                   20


<210> 17436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATAGCTT

<400> 17436
aatagggtaa ctagcagatc                                                   20


<210> 17437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAACGATT

<400> 17437
tatggttaac tctagtcatc                                                   20


<210> 17438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGCTT

<400> 17438
acttattctt tctatctcac                                                   20


<210> 17439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGATT

<400> 17439
atctacttct atgacaaccc                                                   20


<210> 17440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGCTGATT

<400> 17440
atatttgact ttctgtgcct                                                   20


<210> 17441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAGGATT

<400> 17441
cattcatgtt gccacaaata                                                   20


<210> 17442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTATGTTT

<400> 17442
acatatagga gtacagtatt                                                   20


<210> 17443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACTGATT

<400> 17443
tttactgtat ctcttcaaca                                                   20


<210> 17444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAGGATT

<400> 17444
acattctcac aatcagtgtg                                                   20


<210> 17445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGATT

<400> 17445
atcctttaaa cacttatatc                                                   20


<210> 17446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAGGTTT

<400> 17446
gggtgaggag atacctcaag                                                   20


<210> 17447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGATT

<400> 17447
gaggagatac ctcaagatag                                                   20


<210> 17448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGTGATT

<400> 17448
aggtttgatt tgcatttccc                                                   20


<210> 17449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 17449
cttttgtcca tttttgaatt                                                   20


<210> 17450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTTGTTT

<400> 17450
tgtttttttt gtcgttgttg                                                   20


<210> 17451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTATGTTT

<400> 17451
ttgagttgtt tgagttcctt                                                   20


<210> 17452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATAGTTT

<400> 17452
tattaaccca ttatcagatg                                                   20


<210> 17453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGATT

<400> 17453
tgtaggttat ctcttcactc                                                   20


<210> 17454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATTGTTT

<400> 17454
ggttatctct tcactctatt                                                   20


<210> 17455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAAGCTT

<400> 17455
gattgtttgc cttgctgtgc                                                   20


<210> 17456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGTTT

<400> 17456
gccttgctgt gcagaagctt                                                   20


<210> 17457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGCTT

<400> 17457
atataatcca atttgtctat                                                   20


<210> 17458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGCTT

<400> 17458
tctatatttg cttttgttgc                                                   20


<210> 17459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAGGTTT

<400> 17459
gcttttgttg cctgtgcttt                                                   20


<210> 17460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGCTT

<400> 17460
ccttgcctag aacaacatca                                                   20


<210> 17461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCCTGTTT

<400> 17461
acaacatcat gaagctttcc                                                   20


<210> 17462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGTTT

<400> 17462
tttttcttct ctaatagttg                                                   20


<210> 17463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGTTT

<400> 17463
cattcttttg catgtggcta                                                   20


<210> 17464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGATT

<400> 17464
aactcagttg actgtatatg                                                   20


<210> 17465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCTGTTT

<400> 17465
tcttatgtat tgctctgtgt                                                   20


<210> 17466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGTTT

<400> 17466
tctgttttat gtcagtatca                                                   20


<210> 17467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGCTT

<400> 17467
gtatcattct gtttggttac                                                   20


<210> 17468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTATGTTT

<400> 17468
ttggttacta tagctttata                                                   20


<210> 17469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCAGCTT

<400> 17469
aagtcagtta gtgtgaagcc                                                   20


<210> 17470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGTTT

<400> 17470
ttgggctatt tagggtcttt                                                   20


<210> 17471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGGGATT

<400> 17471
gaatgtcact ggtattttga                                                   20


<210> 17472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGATT

<400> 17472
gatagggatt gcattaaacc                                                   20


<210> 17473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATTGCTT

<400> 17473
gggattgcat taaacctgta                                                   20


<210> 17474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGTTT

<400> 17474
aatttctctc accaatattt                                                   20


<210> 17475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTTGTTT

<400> 17475
attgtaaata tatttcacct                                                   20


<210> 17476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGGGATT

<400> 17476
attttttgta gctattgtaa                                                   20


<210> 17477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATTGCTT

<400> 17477
tttgtagcta ttgtaaatgg                                                   20


<210> 17478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGATT

<400> 17478
aatgggattg ctttcttatt                                                   20


<210> 17479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGATT

<400> 17479
ttgttaacat atagaaataa                                                   20


<210> 17480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGATT

<400> 17480
aaataatatt gatttttgca                                                   20


<210> 17481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCCTGATT

<400> 17481
gtcctttatt tctttctctt                                                   20


<210> 17482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAAGCTT

<400> 17482
cttgttccag atcttggaga                                                   20


<210> 17483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGGGTTT

<400> 17483
tggttagtat catgttagct                                                   20


<210> 17484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTATGTTT

<400> 17484
atggccttca ttacattaag                                                   20


<210> 17485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTGGATT

<400> 17485
atttttatca aataaaggat                                                   20


<210> 17486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGCTT

<400> 17486
aaaggatact ggattttata                                                   20


<210> 17487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGATT

<400> 17487
tgctttttct ctgtctattg                                                   20


<210> 17488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATGGTTT

<400> 17488
tctgtctatt gagatgatta                                                   20


<210> 17489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGTTT

<400> 17489
ttgagatgat tatatggttt                                                   20


<210> 17490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAAGTTT

<400> 17490
cattctgttg atataatata                                                   20


<210> 17491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGACGATT

<400> 17491
gaaacatctt tgcatccctg                                                   20


<210> 17492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTGGATT

<400> 17492
aataatcttt ttgataggct                                                   20


<210> 17493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGCTT

<400> 17493
gttcatcagg gatagtggcc                                                   20


<210> 17494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGATT

<400> 17494
atttagaaga attcctttcc                                                   20


<210> 17495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 17495
attagtatta gttcttcttt                                                   20


<210> 17496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGAGATT

<400> 17496
cctggacttt tctttgctag                                                   20


<210> 17497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACTGATT

<400> 17497
tttgctagga gagattttat                                                   20


<210> 17498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCTGTTT

<400> 17498
aatcttgtta ctcattattg                                                   20


<210> 17499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGAGTTT

<400> 17499
gttactcatt attggtctgt                                                   20


<210> 17500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAGGTTT

<400> 17500
gagtaattta tcaatttcca                                                   20


<210> 17501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTATGATT

<400> 17501
aggttttcca atttgttgga                                                   20


<210> 17502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGATT

<400> 17502
gtagctgctg caaacgttgt                                                   20


<210> 17503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 17503
acacataaat aaactgaaaa                                                   20


<210> 17504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTAAGATT

<400> 17504
gctcaaggtc ttatcaaaag                                                   20


<210> 17505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGATT

<400> 17505
ctgggaactc aagtgggaga                                                   20


<210> 17506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGAGGATT

<400> 17506
gagcaggaaa agttagcata                                                   20


<210> 17507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAGGTTT

<400> 17507
ggaaagaaag accttagatg                                                   20


<210> 17508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACAGCTT

<400> 17508
gtaaggtttt tatagttgac                                                   20


<210> 17509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTAGGTTT

<400> 17509
ctcaattctt atattttcag                                                   20


<210> 17510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATGGCTT

<400> 17510
acaacaaaca ctttttttaa                                                   20


<210> 17511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTAGCTT

<400> 17511
atgctacatg acttaaaaat                                                   20


<210> 17512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGATT

<400> 17512
aatattagaa tattaacatc                                                   20


<210> 17513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCAGTTT

<400> 17513
atcaaatgat ttttagacaa                                                   20


<210> 17514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTAGATT

<400> 17514
gacaactcag tttatagggc                                                   20


<210> 17515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATACGCTT

<400> 17515
tttatagggc actagatttc                                                   20


<210> 17516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATGGCTT

<400> 17516
atatataaat tctatagctg                                                   20


<210> 17517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGTTT

<400> 17517
caaattatta agtccaatag                                                   20


<210> 17518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGTTT

<400> 17518
ttattaagtc caataggaat                                                   20


<210> 17519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGTTT

<400> 17519
gtccaatagg aatgtttgtt                                                   20


<210> 17520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTAGATT

<400> 17520
taactgtata actctataac                                                   20


<210> 17521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTAGCTT

<400> 17521
tagatttata actgtataac                                                   20


<210> 17522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCTGCTT

<400> 17522
aaatcacttc cttttaatga                                                   20


<210> 17523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGCTT

<400> 17523
ttgactttcc ccagctcctg                                                   20


<210> 17524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCAAGTTT

<400> 17524
agtgctttaa cacctagaat                                                   20


<210> 17525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGAGTTT

<400> 17525
gcaactgtct gccaggcaat                                                   20


<210> 17526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTAGTTT

<400> 17526
agaaaaaaat aggtgactga                                                   20


<210> 17527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCTGATT

<400> 17527
ccttaaaagg catacgtgga                                                   20


<210> 17528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACGGTTT

<400> 17528
taactttaag ctgaaatgaa                                                   20


<210> 17529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGTGATT

<400> 17529
aacaaatatt tacattgtgt                                                   20


<210> 17530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTAGGTTT

<400> 17530
gtacatatga gaggatgtgt                                                   20


<210> 17531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCAGATT

<400> 17531
atataaagga attgagcatc                                                   20


<210> 17532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTAGATT

<400> 17532
cccatagata tcgagggatg                                                   20


<210> 17533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGATT

<400> 17533
agatatcgag ggatgactag                                                   20


<210> 17534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGATT

<400> 17534
tggctacata gaaacatata                                                   20


<210> 17535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 17535
atatagagca ttttatttta                                                   20


<210> 17536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGATT

<400> 17536
gtatttaatt taatcttatg                                                   20


<210> 17537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTGGCTT

<400> 17537
ctggagtgca gcggtgcgat                                                   20


<210> 17538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGATT

<400> 17538
aacctccgcc tctggagctc                                                   20


<210> 17539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGATT

<400> 17539
tatatatata tatatatcag                                                   20


<210> 17540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTCGTTT

<400> 17540
gtcatgatta ttccatataa                                                   20


<210> 17541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGATT

<400> 17541
taacatgagc tagagaaaac                                                   20


<210> 17542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGTTT

<400> 17542
tgggagagga gggcacaaaa                                                   20


<210> 17543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAAGATT

<400> 17543
atttctcaaa aaattaaaat                                                   20


<210> 17544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGTTT

<400> 17544
gaatccagga agaagtataa                                                   20


<210> 17545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGCGATT

<400> 17545
ttcatttaac cctgacccaa                                                   20


<210> 17546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAGGATT

<400> 17546
aaatacaagg gtgatgcctt                                                   20


<210> 17547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGTGTTT

<400> 17547
aatcccaagc aaagtgtgga                                                   20


<210> 17548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTGGTTT

<400> 17548
tgtttatgac ctaaaaggaa                                                   20


<210> 17549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAGGCTT

<400> 17549
gctggttagg gccatagtgt                                                   20


<210> 17550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGTTT

<400> 17550
gtaatctcag caactgggga                                                   20


<210> 17551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTAGTTT

<400> 17551
ttgaagaatt gcctgagtcc                                                   20


<210> 17552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCCGTTT

<400> 17552
ggcaacagag tgagacctgt                                                   20


<210> 17553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGATT

<400> 17553
atggatacat catgagagtg                                                   20


<210> 17554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCTGCTT

<400> 17554
agcagaggca tcagttgaga                                                   20


<210> 17555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATGGTTT

<400> 17555
tcagttgaga ctctgcttga                                                   20


<210> 17556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTGGATT

<400> 17556
gaaaggtgat gaaaaggaga                                                   20


<210> 17557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGAGCTT

<400> 17557
gggaaggctc aaagatacct                                                   20


<210> 17558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTAAGATT

<400> 17558
gagctttctc atacagctaa                                                   20


<210> 17559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCGGATT

<400> 17559
tcagcattca tattttccaa                                                   20


<210> 17560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGATT

<400> 17560
ttggcactgt cactgtgagg                                                   20


<210> 17561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGATT

<400> 17561
gtgaggctgg gattgtgaat                                                   20


<210> 17562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGTTT

<400> 17562
gaccatcact gtcttccatc                                                   20


<210> 17563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGCTGCTT

<400> 17563
ttccatcaag tgtttgtcca                                                   20


<210> 17564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACTGATT

<400> 17564
gtccacgctg cttccaaaac                                                   20


<210> 17565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGTTT

<400> 17565
agcaagtgta tggttagaaa                                                   20


<210> 17566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGCTT

<400> 17566
tccttcttag tattcagatc                                                   20


<210> 17567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGCTT

<400> 17567
gtcttatctc cctggaaatc                                                   20


<210> 17568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGCTT

<400> 17568
gaaatctttg gctttttgga                                                   20


<210> 17569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAGGTTT

<400> 17569
gcttttagaa taaattcacg                                                   20


<210> 17570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGTTT

<400> 17570
ttagaataaa ttcacgtaag                                                   20


<210> 17571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTTGTTT

<400> 17571
tctagtcact gcaatctgga                                                   20


<210> 17572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTAAGATT

<400> 17572
cagggtcttc ttcaattgct                                                   20


<210> 17573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAGGTTT

<400> 17573
gctcaataat aaggccagaa                                                   20


<210> 17574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGAAGATT

<400> 17574
gccacaatac aaaccagcaa                                                   20


<210> 17575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACTGCTT

<400> 17575
gtccaagaag cgtgctagaa                                                   20


<210> 17576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACCTGATT

<400> 17576
gaaaaggacc tgccccttga                                                   20


<210> 17577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGATT

<400> 17577
attcacatgc aataatggca                                                   20


<210> 17578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTGGCTT

<400> 17578
caataatggc attatgattg                                                   20


<210> 17579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGTTT

<400> 17579
ttggctggct tcattgccta                                                   20


<210> 17580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGATT

<400> 17580
gcctattatg tttgccctag                                                   20


<210> 17581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAAGTTT

<400> 17581
caatttctat tctcttgaag                                                   20


<210> 17582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGTTT

<400> 17582
aattgtaaat tatatttaaa                                                   20


<210> 17583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGTTT

<400> 17583
catggcccaa atcatctacc                                                   20


<210> 17584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCTGATT

<400> 17584
aaaattgtgt gtctcaataa                                                   20


<210> 17585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATGGTTT

<400> 17585
taattgctaa aaatccctga                                                   20


<210> 17586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACATGTTT

<400> 17586
agtatatttc actatgaaat                                                   20


<210> 17587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 17587
tgaaatacat gtttgtgtat                                                   20


<210> 17588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACTGCTT

<400> 17588
gaagatctga gggtccattt                                                   20


<210> 17589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTTGATT

<400> 17589
gaaatattaa taaaatgtat                                                   20


<210> 17590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGATT

<400> 17590
atacttgatt caaagtctca                                                   20


<210> 17591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCAAGTTT

<400> 17591
cattttgatt aatggtcttc                                                   20


<210> 17592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 17592
tgactaaaac ttatttttcc                                                   20


<210> 17593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCCAGTTT

<400> 17593
agaaatataa aaaaagagaa                                                   20


<210> 17594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCTGTTT

<400> 17594
aacactcacc aatatatccc                                                   20


<210> 17595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAGGATT

<400> 17595
cctaataagc atcttaaaaa                                                   20


<210> 17596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTGGTTT

<400> 17596
caaggattag accatgggta                                                   20


<210> 17597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGATT

<400> 17597
ataataaaca tttaaattat                                                   20


<210> 17598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTGGCTT

<400> 17598
catttaaatt atttgtgatt                                                   20


<210> 17599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCATGTTT

<400> 17599
tgattattgg ctttgatgtg                                                   20


<210> 17600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCACGATT

<400> 17600
aagttatacc tttcccaatt                                                   20


<210> 17601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGCTT

<400> 17601
tcaggaggct gaggcagaag                                                   20


<210> 17602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCGAGATT

<400> 17602
actccagcct gggcaacaaa                                                   20


<210> 17603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGAGCTT

<400> 17603
acacaagcaa atcctgctat                                                   20


<210> 17604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGAAGCTT

<400> 17604
tgtaaggcta tataaaacta                                                   20


<210> 17605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTAAGTTT

<400> 17605
tagtgtgtga ctggatgaat                                                   20


<210> 17606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGAGATT

<400> 17606
ccaccttctg gatacctgat                                                   20


<210> 17607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGCAGATT

<400> 17607
caactgtgac aagtcaacgt                                                   20


<210> 17608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCTGCTT

<400> 17608
agcattttat cccaattttc                                                   20


<210> 17609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTAAGCTT

<400> 17609
atcccaattt tctcctgctt                                                   20


<210> 17610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAAGTTT

<400> 17610
tttctcctgc ttgtaagctt                                                   20


<210> 17611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGCAGATT

<400> 17611
aaacactaat tcaaaaagta                                                   20


<210> 17612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATACGATT

<400> 17612
tattttagac tttattgggc                                                   20


<210> 17613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTATGTTT

<400> 17613
acgtaaatga attgacattc                                                   20


<210> 17614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGTTT

<400> 17614
ttgacattcc tatgtttgaa                                                   20


<210> 17615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGATT

<400> 17615
gcatgtgtca tttattcttc                                                   20


<210> 17616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTGGCTT

<400> 17616
cacacaataa caggcattgg                                                   20


<210> 17617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGCTT

<400> 17617
aattatattt tatttactag                                                   20


<210> 17618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGTGATT

<400> 17618
tttgccttaa aatgaatagg                                                   20


<210> 17619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCAGGTTT

<400> 17619
gaacatctgg ttacatacca                                                   20


<210> 17620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATAGCTT

<400> 17620
atcatgtaaa caataaggca                                                   20


<210> 17621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCAGGATT

<400> 17621
atcagcatgt tcaatgttgg                                                   20


<210> 17622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGTTT

<400> 17622
ctcggagcta aaagcaaata                                                   20


<210> 17623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGTTT

<400> 17623
aatcactatg aaaatctttt                                                   20


<210> 17624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGATT

<400> 17624
aatcttttca atgtttccaa                                                   20


<210> 17625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAGGATT

<400> 17625
agaaactatg tacttttagt                                                   20


<210> 17626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGCTT

<400> 17626
aaatctagca tattagagga                                                   20


<210> 17627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 17627
atgtgcttta aaaagtcttt                                                   20


<210> 17628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGTTT

<400> 17628
tattgttaag atcagacaac                                                   20


<210> 17629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAAGCTT

<400> 17629
tcattgaaat tctgtaagcc                                                   20


<210> 17630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGTTT

<400> 17630
aaaaattgta aaaatattca                                                   20


<210> 17631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATGGATT

<400> 17631
tttaagtgca tttgtcaatg                                                   20


<210> 17632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGATT

<400> 17632
tatcaagata taatcttgcc                                                   20


<210> 17633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGTTT

<400> 17633
gccttttgat tcaaattccc                                                   20


<210> 17634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTAGTTT

<400> 17634
ttatagaata taatggcaac                                                   20


<210> 17635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGTTT

<400> 17635
aatataatgg caaccttagt                                                   20


<210> 17636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCAGTTT

<400> 17636
actcatatgg atccatggca                                                   20


<210> 17637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAAGATT

<400> 17637
ttttaatacc atttcagctg                                                   20


<210> 17638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGTTT

<400> 17638
aaagacctaa gtgagaaaaa                                                   20


<210> 17639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACTGTTT

<400> 17639
atcaacacaa tgataataat                                                   20


<210> 17640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGCTT

<400> 17640
acacaatgat aataatcact                                                   20


<210> 17641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GACAGTTT

<400> 17641
ttagcattta ctgtgttcca                                                   20


<210> 17642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGATT

<400> 17642
gaacatgttg actcactctt                                                   20


<210> 17643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGCTT

<400> 17643
ggcagctaaa gtaatacttc                                                   20


<210> 17644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAAGATT

<400> 17644
gactcaagga atctgaccaa                                                   20


<210> 17645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 17645
accaaagaag attctaaggg                                                   20


<210> 17646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAAGATT

<400> 17646
tttcaaataa tgcaggatca                                                   20


<210> 17647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 17647
cttctggtct tcaaatgtca                                                   20


<210> 17648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATGGTTT

<400> 17648
caaagatacc caaagttatt                                                   20


<210> 17649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGAGATT

<400> 17649
ggtttatgaa gagtcataag                                                   20


<210> 17650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 17650
tccatagtca aaaactggca                                                   20


<210> 17651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGTTT

<400> 17651
tctatgtcca gttcaaccat                                                   20


<210> 17652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTTGTTT

<400> 17652
ccattttggt ttctcaaaat                                                   20


<210> 17653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGCTT

<400> 17653
tttctcaaaa tagttgtttt                                                   20


<210> 17654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTTGTTT

<400> 17654
tcaaaatagt tgtttttaaa                                                   20


<210> 17655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGTTT

<400> 17655
agcttgtttc attaagtctt                                                   20


<210> 17656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATAGCTT

<400> 17656
acaatgatgt tgatgatgat                                                   20


<210> 17657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAGGTTT

<400> 17657
tatgtcaaag caatacatcc                                                   20


<210> 17658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCAGATT

<400> 17658
gatatgcata attctgaggc                                                   20


<210> 17659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGTTT

<400> 17659
gtgttccata gccataaata                                                   20


<210> 17660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCTGTTT

<400> 17660
gaacatggag tcagccattt                                                   20


<210> 17661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAGGTTT

<400> 17661
caggcattct aatattgaaa                                                   20


<210> 17662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGTTT

<400> 17662
tctaatattg aaacaaggtt                                                   20


<210> 17663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGATT

<400> 17663
tattgaaaca aggtttatag                                                   20


<210> 17664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTATGTTT

<400> 17664
tgtgatggta aacaggagaa                                                   20


<210> 17665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTATGTTT

<400> 17665
tgtttcctta acagagaaat                                                   20


<210> 17666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGTTT

<400> 17666
ccaatatgca tatttttcac                                                   20


<210> 17667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACAGTTT

<400> 17667
ggggagaggg tagaagccag                                                   20


<210> 17668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGCTT

<400> 17668
agttgtcacc ctttgactat                                                   20


<210> 17669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTAAGATT

<400> 17669
tttgagcgaa tatgtaattt                                                   20


<210> 17670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTTGTTT

<400> 17670
atcacgtagc tctgggttaa                                                   20


<210> 17671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGGGTTT

<400> 17671
atcacccaac atctgtcttt                                                   20


<210> 17672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGTTT

<400> 17672
ttttgccatg ttatcaatgt                                                   20


<210> 17673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACCAGATT

<400> 17673
catgtgccta tttaaggttg                                                   20


<210> 17674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAAGATT

<400> 17674
ttaagaatct gtacagtaaa                                                   20


<210> 17675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGTGTTT

<400> 17675
agattattac ataccttcca                                                   20


<210> 17676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGCTT

<400> 17676
accttccaca gtgtttgtta                                                   20


<210> 17677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGATT

<400> 17677
tacaacgcct tttcttgtgt                                                   20


<210> 17678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGCTT

<400> 17678
attgtaggta taagataaaa                                                   20


<210> 17679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTAGATT

<400> 17679
gtgagtaatt aaaagtagag                                                   20


<210> 17680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCAGTTT

<400> 17680
taggagagct acttaactgt                                                   20


<210> 17681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGTGCTT

<400> 17681
tggtaaaatg gggataatca                                                   20


<210> 17682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTTGCTT

<400> 17682
aaaatgggga taatcatagt                                                   20


<210> 17683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAGGATT

<400> 17683
gtgcttgctt catattcttg                                                   20


<210> 17684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCTGCTT

<400> 17684
atgagataaa aaataaagct                                                   20


<210> 17685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATAGTTT

<400> 17685
ctgagtgttc aatttattca                                                   20


<210> 17686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCAGTTT

<400> 17686
gagcatatga tgataaatga                                                   20


<210> 17687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGTTT

<400> 17687
actatacaac tctagatcta                                                   20


<210> 17688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCTGCTT

<400> 17688
actctagatc tatcatgttt                                                   20


<210> 17689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTAGATT

<400> 17689
atatatttta aatatatatt                                                   20


<210> 17690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCAGGTTT

<400> 17690
tttttgaaaa gtctcgaaaa                                                   20


<210> 17691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCAGATT

<400> 17691
agtctgtcaa acaagaattt                                                   20


<210> 17692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACATGTTT

<400> 17692
acaaattatt ttccatgtag                                                   20


<210> 17693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGTGTTT

<400> 17693
agatgacgtt attagttatg                                                   20


<210> 17694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGTTT

<400> 17694
ccatatattg tgccacaatt                                                   20


<210> 17695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTAGTTT

<400> 17695
tataagtatc cactaattcc                                                   20


<210> 17696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGTTT

<400> 17696
tccactaatt cctctagttt                                                   20


<210> 17697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAGGATT

<400> 17697
ctagttttgt agttttcact                                                   20


<210> 17698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACTGATT

<400> 17698
cactttagga tttattgtga                                                   20


<210> 17699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAAGTTT

<400> 17699
attgcaaaac aaaatgcaag                                                   20


<210> 17700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGATT

<400> 17700
caaaacaaaa tgcaagcaaa                                                   20


<210> 17701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGGGCTT

<400> 17701
taatgaaaaa taccttgcag                                                   20


<210> 17702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATGGATT

<400> 17702
aattgaaata tatgtgtggc                                                   20


<210> 17703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGTTT

<400> 17703
taaatatata agcatgtagc                                                   20


<210> 17704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGCTT

<400> 17704
ataagcatgt agcatatgtt                                                   20


<210> 17705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGATT

<400> 17705
agacctttgg aactgctgta                                                   20


<210> 17706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATTGTTT

<400> 17706
ctttggaact gctgtaaaat                                                   20


<210> 17707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGCTT

<400> 17707
gaactgctgt aaaatgattg                                                   20


<210> 17708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGTTT

<400> 17708
gtaaaatgat tgttttgctt                                                   20


<210> 17709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGTTT

<400> 17709
aatgattgtt ttgcttttat                                                   20


<210> 17710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGCTT

<400> 17710
gcttttatgt ttgtttgtgt                                                   20


<210> 17711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 17711
caatgcttgc atttcagata                                                   20


<210> 17712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGATT

<400> 17712
cttgcatttc agatattttg                                                   20


<210> 17713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGTTT

<400> 17713
ttttttaaaa atgaaaacag                                                   20


<210> 17714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCCGTTT

<400> 17714
caagatctga aacagacagc                                                   20


<210> 17715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTTGCTT

<400> 17715
tagctgagta aattggggca                                                   20


<210> 17716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGTTT

<400> 17716
ggttgtcata aatactaaat                                                   20


<210> 17717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGATT

<400> 17717
tgctgttatt aacaactcaa                                                   20


<210> 17718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGATT

<400> 17718
ccgtcataaa ttgttctcta                                                   20


<210> 17719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGGGATT

<400> 17719
acaagtacct ttttacaaaa                                                   20


<210> 17720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAGGATT

<400> 17720
gatgcctaca acacatagaa                                                   20


<210> 17721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTGGCTT

<400> 17721
ggcagcattg gtggggacct                                                   20


<210> 17722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCTGCTT

<400> 17722
gaaactaaaa agacttgttc                                                   20


<210> 17723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCAGGCTT

<400> 17723
aactttttat atatcaatcc                                                   20


<210> 17724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGAGCTT

<400> 17724
tcagttaaag tgtatttaaa                                                   20


<210> 17725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGCTT

<400> 17725
aagaggagga aaaattcaat                                                   20


<210> 17726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGTGCTT

<400> 17726
ggatctagtt caatagacat                                                   20


<210> 17727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACCAGCTT

<400> 17727
ggtaaggtct ttgcctcaaa                                                   20


<210> 17728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGATT

<400> 17728
tgtgtatatc aggagaatct                                                   20


<210> 17729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTAGATT

<400> 17729
gagaatcttg tagattttta                                                   20


<210> 17730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGTTT

<400> 17730
tgtagatttt taactagatt                                                   20


<210> 17731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGATT

<400> 17731
actagatttt tagtttagaa                                                   20


<210> 17732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGGGATT

<400> 17732
acagaagcaa tggttcatct                                                   20


<210> 17733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAGGTTT

<400> 17733
agcagggagg cctgagagat                                                   20


<210> 17734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGCTT

<400> 17734
ggttgggggt ggaggatatc                                                   20


<210> 17735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACTGTTT

<400> 17735
gtgagtgata ctattaccta                                                   20


<210> 17736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTAAGATT

<400> 17736
aagaaagaag agaaactagt                                                   20


<210> 17737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTAGTTT

<400> 17737
agaagagaaa ctagtctaag                                                   20


<210> 17738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGCTT

<400> 17738
tacaatggtt ctcaggaaca                                                   20


<210> 17739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTAGTTT

<400> 17739
ggaacatttt gcttctgaaa                                                   20


<210> 17740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGATT

<400> 17740
gaaactataa ggtctttcaa                                                   20


<210> 17741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTAGGTTT

<400> 17741
tccataaatg cctagcgata                                                   20


<210> 17742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACCTGATT

<400> 17742
catttagcaa tttgggtggt                                                   20


<210> 17743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCTGATT

<400> 17743
ctttttcttc tgatgctgtc                                                   20


<210> 17744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGATT

<400> 17744
cttctgatgc tgtcctctga                                                   20


<210> 17745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGAGCTT

<400> 17745
ctcccttttc ctctccactg                                                   20


<210> 17746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGATT

<400> 17746
cctctccact ggagagcttc                                                   20


<210> 17747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGTTT

<400> 17747
cttttgattc tttttctttc                                                   20


<210> 17748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCAGTTT

<400> 17748
tttctttagc acttttagag                                                   20


<210> 17749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGATGTTT

<400> 17749
gcacttttag agctcagttt                                                   20


<210> 17750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGCTT

<400> 17750
actctctgag aggcccataa                                                   20


<210> 17751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATCGTTT

<400> 17751
atgtccttta aacatgaaat                                                   20


<210> 17752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGCTT

<400> 17752
ttttctttac acaatgatca                                                   20


<210> 17753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGTTT

<400> 17753
gaatgcttac aaagtatata                                                   20


<210> 17754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGCTT

<400> 17754
taaactatta catgttatta                                                   20


<210> 17755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGTTT

<400> 17755
acaaattaaa tattatatgt                                                   20


<210> 17756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGATT

<400> 17756
accatgcaat aagacagaca                                                   20


<210> 17757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATGGTTT

<400> 17757
atcaatagaa tcaggcactc                                                   20


<210> 17758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGATT

<400> 17758
tcaggcactc tatggtttaa                                                   20


<210> 17759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 17759
cctagtacta tccctttaca                                                   20


<210> 17760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 17760
tactatccct ttacaaaatg                                                   20


<210> 17761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGAGATT

<400> 17761
atgtatgtat aattttaaaa                                                   20


<210> 17762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGATT

<400> 17762
atttaatcca tcattattct                                                   20


<210> 17763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGATT

<400> 17763
ttttccaaaa tttaaatttt                                                   20


<210> 17764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGATT

<400> 17764
tcagaattta tctgcattgc                                                   20


<210> 17765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGATT

<400> 17765
ctaatacatt agactccttg                                                   20


<210> 17766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGTTT

<400> 17766
caactgcagt acatttgaaa                                                   20


<210> 17767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAGGATT

<400> 17767
actgaagaat ctctctggaa                                                   20


<210> 17768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGTTT

<400> 17768
aaaattattt tcttaatatc                                                   20


<210> 17769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACTGTTT

<400> 17769
gacattaaca aaacatgatg                                                   20


<210> 17770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGAGATT

<400> 17770
atattgtata tatatataaa                                                   20


<210> 17771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGATT

<400> 17771
attatttaat caattattct                                                   20


<210> 17772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGTTT

<400> 17772
ttaaaaaaac acatagttcc                                                   20


<210> 17773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGTTT

<400> 17773
acactaagtc attgtaggta                                                   20


<210> 17774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGATT

<400> 17774
agatcacttt tcatgcagtg                                                   20


<210> 17775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACAGTTT

<400> 17775
ttccacacca gaaatgagga                                                   20


<210> 17776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACCGTTT

<400> 17776
taccgcagag cctctgttgt                                                   20


<210> 17777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCAGCTT

<400> 17777
tttaaatcaa ataacagtac                                                   20


<210> 17778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGTTT

<400> 17778
tctgttgaaa ttctaattct                                                   20


<210> 17779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGCTT

<400> 17779
tgaaattcta attctttctg                                                   20


<210> 17780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGTTT

<400> 17780
ttctttctgt ttagcttctt                                                   20


<210> 17781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAAGTTT

<400> 17781
catggcaacc acagccagga                                                   20


<210> 17782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTAGGTTT

<400> 17782
actacgacaa agaagatcat                                                   20


<210> 17783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGTTT

<400> 17783
aaattgtcat ttgaacaata                                                   20


<210> 17784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GACAGTTT

<400> 17784
tgacaggcat gagcaaatct                                                   20


<210> 17785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGCTT

<400> 17785
acgaagaata tagcaatgta                                                   20


<210> 17786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTAAGATT

<400> 17786
tatgcttgta ctaaagtcat                                                   20


<210> 17787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGATT

<400> 17787
gtactaaagt catgtaagat                                                   20


<210> 17788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTCGCTT

<400> 17788
tattttcaat taactttttt                                                   20


<210> 17789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGCTT

<400> 17789
ttaacttttt ttttcgcttt                                                   20


<210> 17790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGTTT

<400> 17790
aaaatagaat tttttttcaa                                                   20


<210> 17791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAGGATT

<400> 17791
aatttttttt caaaatagtt                                                   20


<210> 17792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGAGATT

<400> 17792
ggaaaattaa actgaaggta                                                   20


<210> 17793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCAGGTTT

<400> 17793
tctttttttt ggcataacgt                                                   20


<210> 17794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTGGTTT

<400> 17794
catgggtaga cacgtgccat                                                   20


<210> 17795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGTTGTTT

<400> 17795
cactcatgag tgagaacatg                                                   20


<210> 17796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGTTT

<400> 17796
atgagtgaga acatgcgttg                                                   20


<210> 17797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCTGTTT

<400> 17797
tgcgttgttt ggttttctgt                                                   20


<210> 17798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGTTT

<400> 17798
gtttggtttt ctgttcctgt                                                   20


<210> 17799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATGGTTT

<400> 17799
tgttttagtt tgctgagaat                                                   20


<210> 17800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTAGCTT

<400> 17800
gtttgctgag aatgatggtt                                                   20


<210> 17801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGGGATT

<400> 17801
ttttgggtat atacccagta                                                   20


<210> 17802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACAGTTT

<400> 17802
aactaattta cactcctacc                                                   20


<210> 17803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGTTT

<400> 17803
ggcatgagat ggtatctcat                                                   20


<210> 17804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGAGCTT

<400> 17804
ttctctaatg gccagtgatg                                                   20


<210> 17805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGTTT

<400> 17805
gtgatgatga gctttttttc                                                   20


<210> 17806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTGGTTT

<400> 17806
cacaggtata catgtgctat                                                   20


<210> 17807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTAGGTTT

<400> 17807
tccacctatc aacccattat                                                   20


<210> 17808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGTGTTT

<400> 17808
cacttatgag tgagaacatg                                                   20


<210> 17809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGTTT

<400> 17809
atgagtgaga acatgcagtg                                                   20


<210> 17810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTAGTTT

<400> 17810
gtttggtttt ctcttcctgt                                                   20


<210> 17811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATGGCTT

<400> 17811
tgtattagtt tgctgaggat                                                   20


<210> 17812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGCTT

<400> 17812
gtttgctgag gatgatggct                                                   20


<210> 17813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTTGATT

<400> 17813
ttaacattga tgggcatttg                                                   20


<210> 17814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGATT

<400> 17814
gtgcatgtgt ctttgtagta                                                   20


<210> 17815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTCGTTT

<400> 17815
tttgtagtag aatgatttat                                                   20


<210> 17816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGGGATT

<400> 17816
gtttcggtat atacccagta                                                   20


<210> 17817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGTTT

<400> 17817
ttcatagcct caccagaatc                                                   20


<210> 17818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGTTT

<400> 17818
gacttgagat ggtatctcat                                                   20


<210> 17819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGATT

<400> 17819
gagatggtat ctcattgtgg                                                   20


<210> 17820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGCGTTT

<400> 17820
tatctcattg tggttttgat                                                   20


<210> 17821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGAGCTT

<400> 17821
tttcttaatg atcactgatg                                                   20


<210> 17822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGTTT

<400> 17822
cactgatgtt gagctttttt                                                   20


<210> 17823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACATGATT

<400> 17823
cagaaccaat gacaaaaacc                                                   20


<210> 17824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACATGATT

<400> 17824
tcaaattgtc tctgcaaatg                                                   20


<210> 17825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACAGCTT

<400> 17825
gagaataaaa tacctaggaa                                                   20


<210> 17826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGATT

<400> 17826
ccatactgcc gaaagtaatt                                                   20


<210> 17827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGATT

<400> 17827
gacaaaaaca agcaatgtgg                                                   20


<210> 17828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATGGATT

<400> 17828
ttatacaaaa attaactcaa                                                   20


<210> 17829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGCTT

<400> 17829
aatgggatat aactaaacta                                                   20


<210> 17830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGTTT

<400> 17830
aattatttta atttttttat                                                   20


<210> 17831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGCTT

<400> 17831
atcattttgg tctccttcct                                                   20


<210> 17832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGATT

<400> 17832
ggaagtctac agttgggagc                                                   20


<210> 17833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCAGCTT

<400> 17833
gaaaacagtc catgtgcagg                                                   20


<210> 17834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGAGATT

<400> 17834
actcaggaag gcgagagatc                                                   20


<210> 17835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGATT

<400> 17835
agaaaagata agaaaattat                                                   20


<210> 17836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGAGTTT

<400> 17836
taattttggt aataagataa                                                   20


<210> 17837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCATGTTT

<400> 17837
atgccattca aaaatacaat                                                   20


<210> 17838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGTTT

<400> 17838
cttggtactc acctgttggt                                                   20


<210> 17839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGGGTTT

<400> 17839
aaagctcgtg tagccataat                                                   20


<210> 17840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAGGTTT

<400> 17840
ttactgaaaa gttacaaact                                                   20


<210> 17841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAGGATT

<400> 17841
tataggggga caatattgaa                                                   20


<210> 17842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACATGATT

<400> 17842
attgaataag gattaagaat                                                   20


<210> 17843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGTTT

<400> 17843
tcaagaaaat aagacttgta                                                   20


<210> 17844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTAGCTT

<400> 17844
aagataatgt gtacaaatta                                                   20


<210> 17845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGTTT

<400> 17845
gcttacatcc tgcacataga                                                   20


<210> 17846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGACGTTT

<400> 17846
aaaacatgga aattttcaac                                                   20


<210> 17847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGATT

<400> 17847
tctgtctgta taattcttgg                                                   20


<210> 17848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCAGCTT

<400> 17848
tgtctaagtt cataaaaatg                                                   20


<210> 17849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTGGTTT

<400> 17849
tttctttcta aaattggtgg                                                   20


<210> 17850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGAGATT

<400> 17850
cattaaataa atacaatatt                                                   20


<210> 17851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGTTT

<400> 17851
ttctgggaac agcaacctta                                                   20


<210> 17852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGCTT

<400> 17852
gtctgcatag ggggaaaagc                                                   20


<210> 17853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGCTT

<400> 17853
tacccaagtc caaggaatcc                                                   20


<210> 17854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTCGTTT

<400> 17854
gaaaaataga ctttgtgact                                                   20


<210> 17855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGAGTTT

<400> 17855
attatccaac caacttttgg                                                   20


<210> 17856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAAGATT

<400> 17856
aagtaacatt ttctaccttc                                                   20


<210> 17857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGCTT

<400> 17857
attcgagcac tgtctcaaag                                                   20


<210> 17858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTGGATT

<400> 17858
taactgtgaa cattttaaag                                                   20


<210> 17859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGATT

<400> 17859
ataacatcac agactttaat                                                   20


<210> 17860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTAGTTT

<400> 17860
taaacacgat aaataaaatc                                                   20


<210> 17861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGTTT

<400> 17861
ttagttttat gagacctcct                                                   20


<210> 17862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGAGGATT

<400> 17862
tggctacagt gtggtgagag                                                   20


<210> 17863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGAGTTT

<400> 17863
ggaatttgca tatcatagaa                                                   20


<210> 17864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGATT

<400> 17864
ttgcatatca tagaaatgag                                                   20


<210> 17865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTATGATT

<400> 17865
gaaatgagtt tggattttaa                                                   20


<210> 17866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGACGTTT

<400> 17866
ttctgagaaa tgcatcatta                                                   20


<210> 17867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 17867
cagtaacata agtgagtaaa                                                   20


<210> 17868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCAGATT

<400> 17868
ggagatgaca atgtaatcaa                                                   20


<210> 17869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCATGTTT

<400> 17869
atgtaatcaa tgcagatttt                                                   20


<210> 17870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAGGCTT

<400> 17870
actcttctgt catttgctgt                                                   20


<210> 17871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 17871
cagatctatc cttgtatagt                                                   20


<210> 17872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCTGATT

<400> 17872
tactcaggtc aaattaaaaa                                                   20


<210> 17873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTGGATT

<400> 17873
agactatgaa atcagatatt                                                   20


<210> 17874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGCTT

<400> 17874
cagatattct tggatttgaa                                                   20


<210> 17875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGATT

<400> 17875
tatacaattt gagataaaac                                                   20


<210> 17876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCAGTTT

<400> 17876
cagataaaac aataaagcct                                                   20


<210> 17877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGCTT

<400> 17877
tgtaggtgaa aatgtgcatg                                                   20


<210> 17878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATGGATT

<400> 17878
atccaaaata ttttaataag                                                   20


<210> 17879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTAGGTTT

<400> 17879
agcaatgcag gtagctcact                                                   20


<210> 17880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTGGCTT

<400> 17880
gacattaaat tattaagatg                                                   20


<210> 17881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAAGATT

<400> 17881
tattaagatg gttggcttca                                                   20


<210> 17882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGCTT

<400> 17882
gaatgcaaag aaaaatgaaa                                                   20


<210> 17883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGATGATT

<400> 17883
cttgtgcata ttcaaaagtg                                                   20


<210> 17884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGGAGCTT

<400> 17884
aatggtgtga acccgggagg                                                   20


<210> 17885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGTTT

<400> 17885
ttccacaaaa acttgtacat                                                   20


<210> 17886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGCTT

<400> 17886
gatacaaaaa gccatatatt                                                   20


<210> 17887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTAGATT

<400> 17887
gtaaatccct agggacagaa                                                   20


<210> 17888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGTTT

<400> 17888
ggaatgacta ctaacgggcc                                                   20


<210> 17889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGTTT

<400> 17889
gatcgttgca caactctgag                                                   20


<210> 17890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACAGTTT

<400> 17890
atagtttaaa aaatgagtta                                                   20


<210> 17891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGATT

<400> 17891
agaattgata ttaaatctaa                                                   20


<210> 17892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGTTT

<400> 17892
aatctaatga agattctggg                                                   20


<210> 17893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAAGATT

<400> 17893
tgaagttttt aaattaattt                                                   20


<210> 17894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATGGCTT

<400> 17894
gacaacttat gacaattgtg                                                   20


<210> 17895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCGGTTT

<400> 17895
ttagtagtga aggccaatat                                                   20


<210> 17896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCTGTTT

<400> 17896
aaaacaggag gaagagaata                                                   20


<210> 17897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGTTT

<400> 17897
tcatctgtag cagcataaaa                                                   20


<210> 17898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTATGTTT

<400> 17898
ccaaaggaaa tctacaaatt                                                   20


<210> 17899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGATT

<400> 17899
gtgagacagt gggttaattt                                                   20


<210> 17900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGCTT

<400> 17900
actttgctat aggcaccaga                                                   20


<210> 17901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGATT

<400> 17901
tataggcacc agaaaatgct                                                   20


<210> 17902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGATT

<400> 17902
gattatgctc aggttctctg                                                   20


<210> 17903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACAGCTT

<400> 17903
caagttcttg tcactctttg                                                   20


<210> 17904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGGGTTT

<400> 17904
ctttgaggaa ataaaaacca                                                   20


<210> 17905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCTGTTT

<400> 17905
gtcttctctt ctatctttcc                                                   20


<210> 17906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGATT

<400> 17906
acttctccct ctctctcctg                                                   20


<210> 17907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGCTT

<400> 17907
gccagccatt tgccccatta                                                   20


<210> 17908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCATGATT

<400> 17908
ccttactcct tgatcttgca                                                   20


<210> 17909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCTGTTT

<400> 17909
gcatgattct acacaagcac                                                   20


<210> 17910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGTTT

<400> 17910
caagcacatc tgtttctaca                                                   20


<210> 17911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTGGCTT

<400> 17911
tctacaatat gttttcttct                                                   20


<210> 17912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGCTT

<400> 17912
cttggcttca ttatttatat                                                   20


<210> 17913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACCAGATT

<400> 17913
tcagagttgt agatcttggt                                                   20


<210> 17914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATTGCTT

<400> 17914
agttgtagat cttggtacca                                                   20


<210> 17915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCAGGTTT

<400> 17915
gtaccagatt gctttaaata                                                   20


<210> 17916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCTGATT

<400> 17916
gtgtgtgtgt cctttctttt                                                   20


<210> 17917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCTGATT

<400> 17917
atctccaaac tcagcaggcc                                                   20


<210> 17918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGCTT

<400> 17918
agaaactgag aagtcatcct                                                   20


<210> 17919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCTGTTT

<400> 17919
tttctcttac caaaccacgc                                                   20


<210> 17920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATGGCTT

<400> 17920
cacccacact taaactattt                                                   20


<210> 17921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCAGCTT

<400> 17921
cttcttacta tcttttagat                                                   20


<210> 17922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAAGTTT

<400> 17922
taataaacgc accaataaat                                                   20


<210> 17923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATGGCTT

<400> 17923
gaatcaatta tgcagtcaaa                                                   20


<210> 17924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTTGATT

<400> 17924
gaaacagaag caaaattcag                                                   20


<210> 17925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACAGATT

<400> 17925
gaagaaaata aagaataatg                                                   20


<210> 17926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAGGATT

<400> 17926
ataatgtaca gatttggaag                                                   20


<210> 17927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGATT

<400> 17927
ttggaagaca ggattgtggt                                                   20


<210> 17928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGTTT

<400> 17928
attagctaat tgtcatgcat                                                   20


<210> 17929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GACAGTTT

<400> 17929
attaatttat ttatttttga                                                   20


<210> 17930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGCGATT

<400> 17930
aacctctgcc tcccgagttc                                                   20


<210> 17931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGGGGTTT

<400> 17931
ttttgtattt ttagtagaga                                                   20


<210> 17932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGATT

<400> 17932
aaagcgatga attaaattaa                                                   20


<210> 17933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGAGCTT

<400> 17933
gtctcagcca atcacagcag                                                   20


<210> 17934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCTGATT

<400> 17934
agcttcagcc aaccacagcc                                                   20


<210> 17935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCTGTTT

<400> 17935
tgtcaagcta taagcaatca                                                   20


<210> 17936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAAGTTT

<400> 17936
acagatccca gtgagaaaac                                                   20


<210> 17937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGTTT

<400> 17937
aaattctcca tccattggaa                                                   20


<210> 17938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGTTT

<400> 17938
cattggaaat aagtttcaaa                                                   20


<210> 17939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGTTT

<400> 17939
aaacatttta cttcaaaact                                                   20


<210> 17940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAGGCTT

<400> 17940
aaaactttca gttttcttgt                                                   20


<210> 17941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGATT

<400> 17941
taccatgtgg gctaggtgtt                                                   20


<210> 17942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGTTT

<400> 17942
ggcaacagca catatatttg                                                   20


<210> 17943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAAGATT

<400> 17943
cacctgggtc aaattatcta                                                   20


<210> 17944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGTTT

<400> 17944
gagacaccat gctaggggat                                                   20


<210> 17945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGCTT

<400> 17945
ttgtttagag aacattcaat                                                   20


<210> 17946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGATT

<400> 17946
ggatgttgat aaagctgagc                                                   20


<210> 17947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGCTT

<400> 17947
tgataaagct gagcaaatga                                                   20


<210> 17948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGATT

<400> 17948
ataattaata ttatcattat                                                   20


<210> 17949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATAGCTT

<400> 17949
tccttttgcc agtactgcta                                                   20


<210> 17950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGATGATT

<400> 17950
tgctagatag cttagaacca                                                   20


<210> 17951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCAGCTT

<400> 17951
atgacccaaa ttcacactgt                                                   20


<210> 17952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGCTT

<400> 17952
agcagctttc tatatatttg                                                   20


<210> 17953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGATT

<400> 17953
tatatatttg aatagctttg                                                   20


<210> 17954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGTTT

<400> 17954
atttcattat taaaagagag                                                   20


<210> 17955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGCTT

<400> 17955
ttcactctct agggtattca                                                   20


<210> 17956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGTTT

<400> 17956
agggtattca ttatgctttc                                                   20


<210> 17957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGCTT

<400> 17957
caagtgaatt tcgaaaacat                                                   20


<210> 17958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAGGTTT

<400> 17958
atttcgaaaa catttatgct                                                   20


<210> 17959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAAGCTT

<400> 17959
cagtcaggat catgacatca                                                   20


<210> 17960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGTTT

<400> 17960
ggcctgaaaa tgggagaaaa                                                   20


<210> 17961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAAGCTT

<400> 17961
tctgaatcga aacaaaaaac                                                   20


<210> 17962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGTTT

<400> 17962
cctaattcaa aaaaagcctt                                                   20


<210> 17963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGTTT

<400> 17963
ggtttgctat tttatatata                                                   20


<210> 17964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGTTT

<400> 17964
aaaataattt ttgtaagttc                                                   20


<210> 17965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATGGTTT

<400> 17965
gtaataattt tcaataaaga                                                   20


<210> 17966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATGGATT

<400> 17966
agtattttaa aatcaattaa                                                   20


<210> 17967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGAAGATT

<400> 17967
aacaaaccct cagacaggag                                                   20


<210> 17968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGATT

<400> 17968
ctcatcctaa agacccatgc                                                   20


<210> 17969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGATT

<400> 17969
actcaaaggt tgacttttga                                                   20


<210> 17970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGTTT

<400> 17970
ttaattaaaa ttgcataaag                                                   20


<210> 17971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGTGTTT

<400> 17971
caaaagatca aagtcagccc                                                   20


<210> 17972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGTTT

<400> 17972
ctctcacctg gaatgactga                                                   20


<210> 17973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGGAGTTT

<400> 17973
ctgtcacata tctgtaatag                                                   20


<210> 17974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGCTT

<400> 17974
agttggagtt atgagtggcc                                                   20


<210> 17975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGATT

<400> 17975
tcacaccaat tacttcttac                                                   20


<210> 17976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGTTT

<400> 17976
ttcttacctg ggattacaga                                                   20


<210> 17977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTAGGTTT

<400> 17977
tcgaagagct gaaacattgc                                                   20


<210> 17978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTACGTTT

<400> 17978
gcctttagtc aaggtatttt                                                   20


<210> 17979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGGGCTT

<400> 17979
gtcaaggtat tttctacgtt                                                   20


<210> 17980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGATT

<400> 17980
aactaactta atttaattag                                                   20


<210> 17981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTGGATT

<400> 17981
cagatattat atattattaa                                                   20


<210> 17982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 17982
acttaaatgc gtaaacaact                                                   20


<210> 17983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACTGTTT

<400> 17983
gtcagacaca aaaggctgca                                                   20


<210> 17984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTGGTTT

<400> 17984
atagagataa aacatagatg                                                   20


<210> 17985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGAGTTT

<400> 17985
gaagtgactg ctaatgagta                                                   20


<210> 17986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCAAGTTT

<400> 17986
ttaggtagtg gtgatgttgc                                                   20


<210> 17987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGTTT

<400> 17987
aagaggcagt cttctttgca                                                   20


<210> 17988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTGGATT

<400> 17988
gtctaggtgg ctccagtgaa                                                   20


<210> 17989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGAGATT

<400> 17989
ggaaaataga atatctagat                                                   20


<210> 17990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAGGCTT

<400> 17990
gtgtatacaa tgcattaatc                                                   20


<210> 17991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGAGTTT

<400> 17991
ctgtacttgt atttaaaggc                                                   20


<210> 17992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGTGCTT

<400> 17992
tttaaaggcc tgagtttttt                                                   20


<210> 17993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAGGTTT

<400> 17993
gagttttttg tgtgcttctt                                                   20


<210> 17994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTAGCTT

<400> 17994
ttagtatttg cctatcaatg                                                   20


<210> 17995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGCTT

<400> 17995
ctatcaatga ctagctttca                                                   20


<210> 17996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAGGTTT

<400> 17996
tgctggaaaa atcagacccc                                                   20


<210> 17997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGAGATT

<400> 17997
ttattggaac actgtgctgc                                                   20


<210> 17998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCCGTTT

<400> 17998
gcctgagatt ttcataaatt                                                   20


<210> 17999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAGGATT

<400> 17999
tcctacacag aagcctcttg                                                   20


<210> 18000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGATT

<400> 18000
cctcttgcaa ggatttttac                                                   20


<210> 18001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAAGATT

<400> 18001
cagtaaaagt gtacctaaac                                                   20


<210> 18002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGCTT

<400> 18002
atctgcctaa aaatttccta                                                   20


<210> 18003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGATT

<400> 18003
aagcatataa catgggaagg                                                   20


<210> 18004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCAGTTT

<400> 18004
gttattcatg gtcataaata                                                   20


<210> 18005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTAGCTT

<400> 18005
atgatgagca tgctgaataa                                                   20


<210> 18006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGCTT

<400> 18006
tttgaggatg acacttgttg                                                   20


<210> 18007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGAGCTT

<400> 18007
tcctaagaaa aaaattctaa                                                   20


<210> 18008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGAAGATT

<400> 18008
agcaggtgtg gcattgaaac                                                   20


<210> 18009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATTGTTT

<400> 18009
ggtgtggcat tgaaacggaa                                                   20


<210> 18010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCAGTTT

<400> 18010
caatttttca catcaatatc                                                   20


<210> 18011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGCTT

<400> 18011
ttgagctatt tgttagcatg                                                   20


<210> 18012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGAGCTT

<400> 18012
atttgttagc atgtattgct                                                   20


<210> 18013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTAGCTT

<400> 18013
attttagtta taatactaat                                                   20


<210> 18014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAGGATT

<400> 18014
tttaaaaggg acttaaatta                                                   20


<210> 18015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATAGCTT

<400> 18015
attccataag tgtccttttc                                                   20


<210> 18016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTGGCTT

<400> 18016
atattaaagc aacctaaagc                                                   20


<210> 18017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGGGTTT

<400> 18017
aattttatat agggttatca                                                   20


<210> 18018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAGGCTT

<400> 18018
tcaggaggta agtctgtgag                                                   20


<210> 18019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGTTT

<400> 18019
caagaaaaca aatcagagtc                                                   20


<210> 18020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATGGTTT

<400> 18020
tctttctgca attgtattga                                                   20


<210> 18021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGATT

<400> 18021
caggggaggg acctggtggt                                                   20


<210> 18022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCGGTTT

<400> 18022
gtaagtgatt ggatcatggg                                                   20


<210> 18023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGGGTTT

<400> 18023
gtgagttctc atgagatctg                                                   20


<210> 18024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTTGCTT

<400> 18024
ctgcaccatg ttaagatgtg                                                   20


<210> 18025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCATGATT

<400> 18025
tgcttcccct ttgccttcga                                                   20


<210> 18026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTAAGTTT

<400> 18026
ctttgccttc gaccatgatt                                                   20


<210> 18027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGGAGCTT

<400> 18027
aatggcgtga acccgggagg                                                   20


<210> 18028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGAGTTT

<400> 18028
tatcataaca ggtaatgaaa                                                   20


<210> 18029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGAGTTT

<400> 18029
agtttgaaca aaaataaggc                                                   20


<210> 18030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGATT

<400> 18030
cattctcatt aaaaactttt                                                   20


<210> 18031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTATGATT

<400> 18031
ttattagcag gaaaaaatag                                                   20


<210> 18032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGCTT

<400> 18032
aacattatac taaatttcac                                                   20


<210> 18033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACAGATT

<400> 18033
ccatactgcc caaggtaatt                                                   20


<210> 18034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGATT

<400> 18034
gagaaaaaca agcaatgggg                                                   20


<210> 18035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATGGATT

<400> 18035
ttatacaaaa atcaattcaa                                                   20


<210> 18036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGCTT

<400> 18036
aatgggatct aattaaacta                                                   20


<210> 18037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGCGATT

<400> 18037
aaccattgtg gaagtcagtg                                                   20


<210> 18038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGTTT

<400> 18038
ctataaagac acatgcacac                                                   20


<210> 18039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTGGATT

<400> 18039
caaatgtcca acaatgatag                                                   20


<210> 18040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACAGATT

<400> 18040
caatgaaaaa tttgaaaaag                                                   20


<210> 18041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCTGTTT

<400> 18041
tgtccccata gatgaagggc                                                   20


<210> 18042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCCAGCTT

<400> 18042
tagatgaagg gcagctgttt                                                   20


<210> 18043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACTGCTT

<400> 18043
ctgtttgcca gcttccaagt                                                   20


<210> 18044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTGGCTT

<400> 18044
tgccagcttc caagtcactg                                                   20


<210> 18045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGGGCTT

<400> 18045
tccaagtcac tgcttggctt                                                   20


<210> 18046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGATT

<400> 18046
ttcttttctt ctttgggttc                                                   20


<210> 18047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GACTGTTT

<400> 18047
gttgttcaat gagggcaaga                                                   20


<210> 18048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACAGATT

<400> 18048
aaactaataa taacaacata                                                   20


<210> 18049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGTTT

<400> 18049
aataacaaca taaacagatt                                                   20


<210> 18050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCAGCTT

<400> 18050
aggtaacatg ttctagaatt                                                   20


<210> 18051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGGGATT

<400> 18051
tctagaatta tcagcttgtt                                                   20


<210> 18052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGTTT

<400> 18052
catctttata ctcagaaatt                                                   20


<210> 18053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTACGCTT

<400> 18053
tatactcaga aatttgaagt                                                   20


<210> 18054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATAGCTT

<400> 18054
gaaatttgaa gtttacgctt                                                   20


<210> 18055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCTGTTT

<400> 18055
agcaccactc tccagcctga                                                   20


<210> 18056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAAGATT

<400> 18056
ttcataacat cttgaccagg                                                   20


<210> 18057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGCTT

<400> 18057
ccatctcacg aaaccacttt                                                   20


<210> 18058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGTTT

<400> 18058
aactcattcc aatttcctat                                                   20


<210> 18059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAAGATT

<400> 18059
tagaatggtg aatcctttcc                                                   20


<210> 18060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCAGGCTT

<400> 18060
gtaaacagac gtgctgtcat                                                   20


<210> 18061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTAGATT

<400> 18061
tatttataga gcacaggcag                                                   20


<210> 18062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGATT

<400> 18062
gtagatttag tataattctt                                                   20


<210> 18063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGATT

<400> 18063
taattcttaa gagattttct                                                   20


<210> 18064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTAAGATT

<400> 18064
aataattaaa taatataatt                                                   20


<210> 18065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGCTT

<400> 18065
tttctgaacg ataaattagc                                                   20


<210> 18066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGCTT

<400> 18066
aagagagtca gcctgttcgt                                                   20


<210> 18067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGTTT

<400> 18067
ttagaccttc attgcaaatc                                                   20


<210> 18068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCTGTTT

<400> 18068
gcatcttctc cattggcact                                                   20


<210> 18069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCCAGCTT

<400> 18069
aatctcatgg ggtaccgtct                                                   20


<210> 18070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGCTT

<400> 18070
ccagcttcaa accttttttt                                                   20


<210> 18071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGATT

<400> 18071
aattggagtt atggccttgc                                                   20


<210> 18072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAGGCTT

<400> 18072
agttatggcc ttgctgtgga                                                   20


<210> 18073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGCTT

<400> 18073
ggccttgctg tggattaggc                                                   20


<210> 18074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGCTGTTT

<400> 18074
tttctctata tttgcaataa                                                   20


<210> 18075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 18075
ctatatttgc aataaggctg                                                   20


<210> 18076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGATT

<400> 18076
tgtgttcact ggagtagcac                                                   20


<210> 18077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGTTT

<400> 18077
gcacatttga tttccttcaa                                                   20


<210> 18078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTAGATT

<400> 18078
taagtactta gtgcaagagg                                                   20


<210> 18079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTGGCTT

<400> 18079
aggcctagat tttggcctat                                                   20


<210> 18080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTAAGCTT

<400> 18080
ctttcaacat gccttcctca                                                   20


<210> 18081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTAGCTT

<400> 18081
cctcactaag cttaatcatt                                                   20


<210> 18082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGATT

<400> 18082
taagcttaat catttctagc                                                   20


<210> 18083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGATT

<400> 18083
gaaacagaac acgtcacatt                                                   20


<210> 18084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATTGTTT

<400> 18084
cagaacacgt cacatttaat                                                   20


<210> 18085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTTGCTT

<400> 18085
tgaaaaaatt acgctgacag                                                   20


<210> 18086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGTTT

<400> 18086
atggaaacca aagttaggat                                                   20


<210> 18087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGATGATT

<400> 18087
catatacaca ttcaaaagta                                                   20


<210> 18088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAACGTTT

<400> 18088
taaaacatat gtccacacaa                                                   20


<210> 18089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGATT

<400> 18089
gagccaaaag gccacatacg                                                   20


<210> 18090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGATT

<400> 18090
cagaggctgg gtgtaatagg                                                   20


<210> 18091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGGGCTT

<400> 18091
tggttaatgg ttaaagagta                                                   20


<210> 18092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGATGATT

<400> 18092
aatattctaa aactacataa                                                   20


<210> 18093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGTGATT

<400> 18093
ctgagtgata cactttaaaa                                                   20


<210> 18094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGATT

<400> 18094
aaaattgtcc tcagaatagg                                                   20


<210> 18095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGCTT

<400> 18095
caaatcaaag cagttgccac                                                   20


<210> 18096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGAGATT

<400> 18096
agcagttgcc acttgtgctt                                                   20


<210> 18097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTGGCTT

<400> 18097
actgtggctc ttgaagaaaa                                                   20


<210> 18098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGTGTTT

<400> 18098
gaaaagttgg cttgaataac                                                   20


<210> 18099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGATT

<400> 18099
gcttgaataa ctggtgtttt                                                   20


<210> 18100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACCAGTTT

<400> 18100
tgtgaactca gatgtccatt                                                   20


<210> 18101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGATT

<400> 18101
aactcagatg tccattacca                                                   20


<210> 18102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACCTGCTT

<400> 18102
attaaaggaa gacactaagc                                                   20


<210> 18103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCAGATT

<400> 18103
tggaagttga agagaccttg                                                   20


<210> 18104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTAGTTT

<400> 18104
atcagatttc atcatcatcc                                                   20


<210> 18105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGCTT

<400> 18105
tcctttcatt ttactaattt                                                   20


<210> 18106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCAGCTT

<400> 18106
attttatagc tttgaagaag                                                   20


<210> 18107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGAGTTT

<400> 18107
agagcagctt tagttggcat                                                   20


<210> 18108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGCTT

<400> 18108
cagctttagt tggcatctga                                                   20


<210> 18109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGAGTTT

<400> 18109
cttctggata aacaggccac                                                   20


<210> 18110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGTTT

<400> 18110
gagttttcat tagtcaggca                                                   20


<210> 18111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAAGATT

<400> 18111
tcattagtca ggcatttagt                                                   20


<210> 18112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGAGATT

<400> 18112
tcaggcattt agtttaagat                                                   20


<210> 18113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTAGATT

<400> 18113
aatcgaaaaa gataaagaat                                                   20


<210> 18114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAGGTTT

<400> 18114
agatttaatc tcataacaat                                                   20


<210> 18115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGCTT

<400> 18115
tacaatacaa atgacagatg                                                   20


<210> 18116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAAGATT

<400> 18116
tttggcctat taatcattag                                                   20


<210> 18117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGGAGCTT

<400> 18117
aatggcgtga acccaggagg                                                   20


<210> 18118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTCGTTT

<400> 18118
caaaagcctt aaacacgtga                                                   20


<210> 18119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCAGCTT

<400> 18119
gaatgtataa tgaaataatg                                                   20


<210> 18120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAAGTTT

<400> 18120
taaatacaca atgcatttaa                                                   20


<210> 18121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGATT

<400> 18121
aacaaagttt agccctagtt                                                   20


<210> 18122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATGGATT

<400> 18122
tttagcccta gttaagagat                                                   20


<210> 18123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGTTT

<400> 18123
aaatttgtac aacgaaaatg                                                   20


<210> 18124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGTTT

<400> 18124
tcaatcaata tttattcttg                                                   20


<210> 18125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTATGATT

<400> 18125
ttccactttt attaacatta                                                   20


<210> 18126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 18126
gttgcatata aaggcagtac                                                   20


<210> 18127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTAAGATT

<400> 18127
tgaatgtgtt attcttgtat                                                   20


<210> 18128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGTTT

<400> 18128
agacacacac atatatatag                                                   20


<210> 18129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTATGCTT

<400> 18129
tatatataga tatgttttat                                                   20


<210> 18130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGTTT

<400> 18130
catgaaaatg gtcttatccc                                                   20


<210> 18131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGATT

<400> 18131
aaaaaaagtt atcataaatc                                                   20


<210> 18132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACAGATT

<400> 18132
tttctttcta gcagagaagt                                                   20


<210> 18133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTTGATT

<400> 18133
gtgatgtaga tcagaaaaca                                                   20


<210> 18134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATGGATT

<400> 18134
agaaaacaag ttgattaatc                                                   20


<210> 18135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTGGTTT

<400> 18135
ctatgttaaa tatgtagcag                                                   20


<210> 18136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAGGATT

<400> 18136
agtcatccct ctctttcaag                                                   20


<210> 18137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGATT

<400> 18137
gcctttcttc cataaatatt                                                   20


<210> 18138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGCTT

<400> 18138
acatcaattc tgggtaaagg                                                   20


<210> 18139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGCTT

<400> 18139
tgaaacaaaa aatttcagta                                                   20


<210> 18140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTAGATT

<400> 18140
aaatgcatgg agttctatat                                                   20


<210> 18141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAAGTTT

<400> 18141
tttaaaagtt ccattcttgt                                                   20


<210> 18142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAAGATT

<400> 18142
ttagagcatt aacaatagaa                                                   20


<210> 18143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTAGATT

<400> 18143
actaactaaa aagaatgaaa                                                   20


<210> 18144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGCTT

<400> 18144
aattgacact agaacacaat                                                   20


<210> 18145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGATT

<400> 18145
atcttttttt tttaagttac                                                   20


<210> 18146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGTTT

<400> 18146
tctaaaacac atagaataca                                                   20


<210> 18147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 18147
tgtgaataaa agcaaaggga                                                   20


<210> 18148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGAGTTT

<400> 18148
ttgaagcaga gaggatccac                                                   20


<210> 18149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGAGTTT

<400> 18149
ttgatgtgtt cttcaagtag                                                   20


<210> 18150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAGGTTT

<400> 18150
caagtagcag agtttgaatg                                                   20


<210> 18151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTTGTTT

<400> 18151
cctctagatc aaaccatgtt                                                   20


<210> 18152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGCTT

<400> 18152
tatcagtgta aaagtaatgg                                                   20


<210> 18153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGGGGATT

<400> 18153
tacaaaaatt gagaggtaga                                                   20


<210> 18154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGTTT

<400> 18154
ggcagttagt gcatcctggc                                                   20


<210> 18155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACTGCTT

<400> 18155
ttacttagaa atgaaaacat                                                   20


<210> 18156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGTTT

<400> 18156
tgagaatggg gcagaaagag                                                   20


<210> 18157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGATT

<400> 18157
ctttttttta aaaaagcggg                                                   20


<210> 18158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATGGCTT

<400> 18158
gaagtgatta ttccctagat                                                   20


<210> 18159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGTTT

<400> 18159
ctttaaaggg ataaagcaaa                                                   20


<210> 18160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGATT

<400> 18160
taattttata atagttatta                                                   20


<210> 18161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCTGCTT

<400> 18161
agccaaagaa accaacaaac                                                   20


<210> 18162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGCTT

<400> 18162
aaactgttct gttaccttca                                                   20


<210> 18163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGATT

<400> 18163
gcaaacactc aaagttacag                                                   20


<210> 18164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCTGCTT

<400> 18164
aagattgtgt cttctacttt                                                   20


<210> 18165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTGGCTT

<400> 18165
ttcattgggt gctaccaatg                                                   20


<210> 18166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATGGTTT

<400> 18166
aatggctggc ttgctgaatg                                                   20


<210> 18167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGAGCTT

<400> 18167
ctgacaccaa ttcttccata                                                   20


<210> 18168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGTTT

<400> 18168
aataacccac aacacaaaat                                                   20


<210> 18169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCTGTTT

<400> 18169
aaaattaatg ttttattatc                                                   20


<210> 18170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACTGTTT

<400> 18170
tctgctgttt tccaaaatac                                                   20


<210> 18171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGGGCTT

<400> 18171
acctaaaaaa atacagatgc                                                   20


<210> 18172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGTTT

<400> 18172
tatctaagta atgctgaaat                                                   20


<210> 18173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGATT

<400> 18173
aatactaacg tgaaccctcc                                                   20


<210> 18174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCAGGTTT

<400> 18174
gagtacacat acatcaatga                                                   20


<210> 18175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGTTT

<400> 18175
aaattcaatt caaaaagtag                                                   20


<210> 18176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGATT

<400> 18176
attcaaaaag tagaaaagtt                                                   20


<210> 18177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 18177
aaagtagaaa agtttttgga                                                   20


<210> 18178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGTTT

<400> 18178
agaaaagttt ttggattttg                                                   20


<210> 18179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCTGCTT

<400> 18179
agctgtgcac ctgtagtctc                                                   20


<210> 18180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGCTT

<400> 18180
ccatgatcac accactgcgg                                                   20


<210> 18181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGTTT

<400> 18181
ataaaccaaa aagggtaaaa                                                   20


<210> 18182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGTTT

<400> 18182
aagggtaaaa aaaagttttt                                                   20


<210> 18183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGAGTTT

<400> 18183
aggcatgcag tgctcctcct                                                   20


<210> 18184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGATT

<400> 18184
aggacaaaga tactaaaaga                                                   20


<210> 18185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGAGTTT

<400> 18185
taaaaaaaat ttcattttat                                                   20


<210> 18186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGTTT

<400> 18186
tttcatttta tttgagtttc                                                   20


<210> 18187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGAGCTT

<400> 18187
tctatagttt cttcttaatt                                                   20


<210> 18188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTCGATT

<400> 18188
tgtaaaatct ttaatataca                                                   20


<210> 18189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTGGTTT

<400> 18189
ttccatacag aacaattcac                                                   20


<210> 18190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTAAGATT

<400> 18190
atgacataac ctctctgagc                                                   20


<210> 18191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTAGTTT

<400> 18191
acctctctga gcctaagatt                                                   20


<210> 18192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTGGTTT

<400> 18192
ttaataatca tgctccgaag                                                   20


<210> 18193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGATT

<400> 18193
aatcatgctc cgaagagtgg                                                   20


<210> 18194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGCTT

<400> 18194
gtgatggtta actgtatata                                                   20


<210> 18195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGTTT

<400> 18195
tatataaagt gcttaacagg                                                   20


<210> 18196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGATT

<400> 18196
aacacgtatt catggagctc                                                   20


<210> 18197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTTGCTT

<400> 18197
ctcatccttc tattttaatt                                                   20


<210> 18198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGCTT

<400> 18198
ccttgctttg gataatttta                                                   20


<210> 18199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGAGATT

<400> 18199
tatgagcatg taatattaaa                                                   20


<210> 18200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGTTT

<400> 18200
catgtaatat taaacagaga                                                   20


<210> 18201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGTTT

<400> 18201
aagttcagga gctagaaagc                                                   20


<210> 18202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTGGATT

<400> 18202
agaaagcctg ggttttgaat                                                   20


<210> 18203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGATT

<400> 18203
acatcccagt taagcaactt                                                   20


<210> 18204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGATT

<400> 18204
aagagtatcc ctagaatgac                                                   20


<210> 18205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGATT

<400> 18205
agaatgactg ttgattgctc                                                   20


<210> 18206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGTTT

<400> 18206
aattcccatc atttcacctt                                                   20


<210> 18207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTGGTTT

<400> 18207
aaagcaaata aattccaaca                                                   20


<210> 18208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGAGTTT

<400> 18208
aagaaatatt acagtctctc                                                   20


<210> 18209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGGGTTT

<400> 18209
tctataggat gaggtgggaa                                                   20


<210> 18210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGATT

<400> 18210
tactccaaac tgcagttccc                                                   20


<210> 18211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGCTT

<400> 18211
ccatataatt ttgtaatatg                                                   20


<210> 18212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGTTT

<400> 18212
tgttgtgctt ttgtaataat                                                   20


<210> 18213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTATGTTT

<400> 18213
ccagataatt cctttaaaca                                                   20


<210> 18214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGTGTTT

<400> 18214
catctcttgt agaaagcaag                                                   20


<210> 18215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTTGTTT

<400> 18215
gtagaaagca agtagtgttt                                                   20


<210> 18216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGTTT

<400> 18216
aaagcaagta gtgtttactt                                                   20


<210> 18217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGATT

<400> 18217
ttacttgttt gtttctttaa                                                   20


<210> 18218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGCTGTTT

<400> 18218
acaactctat aataatttca                                                   20


<210> 18219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGAGATT

<400> 18219
gaagatctgc caaaatctga                                                   20


<210> 18220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACTGCTT

<400> 18220
ctaactgttg taaaatgaaa                                                   20


<210> 18221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGTGATT

<400> 18221
gtcacttctc tagaaacaca                                                   20


<210> 18222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGTTT

<400> 18222
aatcagaaca tgagaaccta                                                   20


<210> 18223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGCTT

<400> 18223
gagaaattgc gacagcctag                                                   20


<210> 18224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATGGTTT

<400> 18224
ttaataataa tgatgtatca                                                   20


<210> 18225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGTTT

<400> 18225
ccataaatct attccaagac                                                   20


<210> 18226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGCTT

<400> 18226
ttttacacag tacaaaatag                                                   20


<210> 18227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCAGTTT

<400> 18227
gagatccatt agaaatgctg                                                   20


<210> 18228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGAGCTT

<400> 18228
tgcactctcc tgggtcagga                                                   20


<210> 18229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGCTT

<400> 18229
tatcttttaa gttgttaaat                                                   20


<210> 18230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGATT

<400> 18230
ttaaggtaca aaaggctgac                                                   20


<210> 18231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGAGATT

<400> 18231
taaaagaaat gtatttgact                                                   20


<210> 18232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATACGCTT

<400> 18232
ctccactctg gctgacaagg                                                   20


<210> 18233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTGGTTT

<400> 18233
ctgacaagga tacgcttaac                                                   20


<210> 18234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGTTT

<400> 18234
atcaggagag atgagagagg                                                   20


<210> 18235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCCGATT

<400> 18235
gagtccttcc tacacctggc                                                   20


<210> 18236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACAGTTT

<400> 18236
atttagtcat tgaatagctc                                                   20


<210> 18237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAACGATT

<400> 18237
ataagaaagt caaaggtgcg                                                   20


<210> 18238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGATT

<400> 18238
tgtcagggtt acacttataa                                                   20


<210> 18239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCAGGATT

<400> 18239
tacagcattt atgttccaag                                                   20


<210> 18240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCAAGCTT

<400> 18240
atgaccttgg actgttctag                                                   20


<210> 18241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAAGATT

<400> 18241
tagttattgt gaacttttct                                                   20


<210> 18242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGTGTTT

<400> 18242
agatgtcata tattaatcac                                                   20


<210> 18243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGCTT

<400> 18243
tagtgtttgg aaatcctgca                                                   20


<210> 18244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGAGCTT

<400> 18244
aataacatcc tagggagtct                                                   20


<210> 18245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGTTT

<400> 18245
cactatgggt tatcttcaaa                                                   20


<210> 18246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGCGTTT

<400> 18246
aataaacaca atatttaata                                                   20


<210> 18247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGAGTTT

<400> 18247
ctgtaatatg ggcagaaagt                                                   20


<210> 18248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGTTT

<400> 18248
aattgccaac attctactta                                                   20


<210> 18249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTAGATT

<400> 18249
ttatcttact cttcccctag                                                   20


<210> 18250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGGGATT

<400> 18250
tggttgtaat ttattatatt                                                   20


<210> 18251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGCTT

<400> 18251
ttcctcacta caacacctca                                                   20


<210> 18252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGAGCTT

<400> 18252
ttcacatctc attgatacta                                                   20


<210> 18253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACAGCTT

<400> 18253
ttaactattg tccatgaata                                                   20


<210> 18254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGCTT

<400> 18254
agtgtatctt tagcctgtaa                                                   20


<210> 18255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGTTT

<400> 18255
ggaacaaagc agacctgtca                                                   20


<210> 18256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGTTT

<400> 18256
tattctagag tgaaggaatt                                                   20


<210> 18257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATGGTTT

<400> 18257
tttcatccca gtattggtta                                                   20


<210> 18258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGTTT

<400> 18258
atcccagtat tggttacatg                                                   20


<210> 18259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTCGTTT

<400> 18259
agtattggtt acatggtttg                                                   20


<210> 18260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCAGGTTT

<400> 18260
ttaagttcag gagtacaagt                                                   20


<210> 18261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGGGGTTT

<400> 18261
cataggtaaa cttgtgtcat                                                   20


<210> 18262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGTTT

<400> 18262
ggtaaacttg tgtcatgggg                                                   20


<210> 18263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACAGCTT

<400> 18263
tgtgtcatgg gggtttgttt                                                   20


<210> 18264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGTGTTT

<400> 18264
tgtatttgaa aggttccagt                                                   20


<210> 18265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 18265
aagttaaaaa gatgaacgta                                                   20


<210> 18266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCCTGTTT

<400> 18266
tgaagaatat tagaataggc                                                   20


<210> 18267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAGGTTT

<400> 18267
aaaatgacta cacaaagcaa                                                   20


<210> 18268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGTTT

<400> 18268
actacacaaa gcaataaggt                                                   20


<210> 18269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATGGTTT

<400> 18269
aagcaataag gtttatgttt                                                   20


<210> 18270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACTGATT

<400> 18270
taccattatt tgtatatgaa                                                   20


<210> 18271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGTGATT

<400> 18271
tattttagtc tacaacattt                                                   20


<210> 18272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAGGTTT

<400> 18272
aattggtaaa gtaattgctc                                                   20


<210> 18273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGATT

<400> 18273
aagtgaccag ccatcaatta                                                   20


<210> 18274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTAGTTT

<400> 18274
tgctagcaca attaacagaa                                                   20


<210> 18275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGATT

<400> 18275
atttttcttt attaaactac                                                   20


<210> 18276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGATT

<400> 18276
ccaaaacaaa atgaaggtag                                                   20


<210> 18277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAGGTTT

<400> 18277
aatgaaggta gtcttgattt                                                   20


<210> 18278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGTTT

<400> 18278
ctctagttgt tacccatttt                                                   20


<210> 18279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGTTT

<400> 18279
tgttgggggg gggttgttgt                                                   20


<210> 18280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGGGCTT

<400> 18280
tggccttgat ccttgtcctc                                                   20


<210> 18281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAAGATT

<400> 18281
acctaacttg gacttaggaa                                                   20


<210> 18282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACAGTTT

<400> 18282
caattcctcc ctcttgtgtt                                                   20


<210> 18283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGCTT

<400> 18283
caggagctgt ctccttcatt                                                   20


<210> 18284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCTGATT

<400> 18284
atttttggct ttgtcatcaa                                                   20


<210> 18285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGCTT

<400> 18285
aaacaagaaa aaaaatcatc                                                   20


<210> 18286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGCTT

<400> 18286
cttcgatgga atttgaaata                                                   20


<210> 18287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTAGATT

<400> 18287
atatatagct tcataaactc                                                   20


<210> 18288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAAGCTT

<400> 18288
taaaaatttt aaaggatgca                                                   20


<210> 18289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACAGATT

<400> 18289
caaccaaagt tcctgcattc                                                   20


<210> 18290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCCAGTTT

<400> 18290
ctcaagttcc aggttaaatt                                                   20


<210> 18291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACCTGTTT

<400> 18291
atcccattct ctgccactct                                                   20


<210> 18292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCATGCTT

<400> 18292
actctacctg tttttcattc                                                   20


<210> 18293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGTTT

<400> 18293
catgcttagc aaccattata                                                   20


<210> 18294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGTTT

<400> 18294
taatgtgttt atgaacatct                                                   20


<210> 18295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGTTT

<400> 18295
ctaatttaca tacattttct                                                   20


<210> 18296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGTTT

<400> 18296
tttacataca ttttctcatt                                                   20


<210> 18297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTATGATT

<400> 18297
ttgtttttat ttactaagca                                                   20


<210> 18298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTGGTTT

<400> 18298
caaccttctt ggaaccaagg                                                   20


<210> 18299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTAGGTTT

<400> 18299
tcagggcagc agggaaggag                                                   20


<210> 18300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGCTT

<400> 18300
ctcgtatgtg cagttcacaa                                                   20


<210> 18301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCAGGTTT

<400> 18301
actgtggcct ataaacagat                                                   20


<210> 18302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGCTT

<400> 18302
agatccaggt tttatggatc                                                   20


<210> 18303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GACAGATT

<400> 18303
agggcaaatt aggcacaaaa                                                   20


<210> 18304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGTTT

<400> 18304
agacagatta atataaaagt                                                   20


<210> 18305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGCTT

<400> 18305
ctttaggact tcccttcatt                                                   20


<210> 18306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGAGTTT

<400> 18306
tgatagttga gcaaatttct                                                   20


<210> 18307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTTGTTT

<400> 18307
aaatttctct gagttttaca                                                   20


<210> 18308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAAGTTT

<400> 18308
caaatttggg aacacctcca                                                   20


<210> 18309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGTTT

<400> 18309
cctcaatgta gtgatgtatg                                                   20


<210> 18310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACATGTTT

<400> 18310
atgaagagtt tgttatctca                                                   20


<210> 18311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGATT

<400> 18311
tatttttcct caacatattc                                                   20


<210> 18312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTGGATT

<400> 18312
tgattcactc ttctttataa                                                   20


<210> 18313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGCTT

<400> 18313
tgagaaataa tactttttac                                                   20


<210> 18314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGTTT

<400> 18314
ttgctcaatg ttaatataat                                                   20


<210> 18315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 18315
ttattgctca tccttgtaac                                                   20


<210> 18316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTAAGCTT

<400> 18316
agtggtgagg ccatcatctc                                                   20


<210> 18317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATGGATT

<400> 18317
tcatctccta agcttattca                                                   20


<210> 18318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGAAGATT

<400> 18318
ggtgaatgaa gccaaataaa                                                   20


<210> 18319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTAGATT

<400> 18319
gctgggtctg ccaaacagcc                                                   20


<210> 18320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTAGTTT

<400> 18320
tcattttcct atacagctgc                                                   20


<210> 18321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGCTT

<400> 18321
caacttccaa taaatctcca                                                   20


<210> 18322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGTGTTT

<400> 18322
tccatttggc ttgggacagc                                                   20


<210> 18323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGTTT

<400> 18323
tttggcttgg gacagccagt                                                   20


<210> 18324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGCTT

<400> 18324
ggacagccag tgtttgtttc                                                   20


<210> 18325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGCTT

<400> 18325
ctcttgcttg taatcaatat                                                   20


<210> 18326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GACAGTTT

<400> 18326
aacaagctcc ttttggctat                                                   20


<210> 18327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGATT

<400> 18327
ttggctatga cagttttgct                                                   20


<210> 18328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGTGATT

<400> 18328
taatcacttg acctcagaag                                                   20


<210> 18329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGATGATT

<400> 18329
cttatactat aaaatagata                                                   20


<210> 18330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACTGCTT

<400> 18330
aaattcactt taaatataca                                                   20


<210> 18331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTAGTTT

<400> 18331
atatcttcta cactattatt                                                   20


<210> 18332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 18332
catattctga ccataaatgg                                                   20


<210> 18333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGTTT

<400> 18333
tcttaatctt aaaatttact                                                   20


<210> 18334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGAGATT

<400> 18334
taaatgatca gtatgtaaat                                                   20


<210> 18335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGATGATT

<400> 18335
ttcttttctg aaaatttcct                                                   20


<210> 18336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTGGCTT

<400> 18336
ttctgaaaat ttcctcgatg                                                   20


<210> 18337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTTGTTT

<400> 18337
attggctttc attaacagct                                                   20


<210> 18338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGCTT

<400> 18338
ttaatgagaa catcgtgaag                                                   20


<210> 18339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGCTT

<400> 18339
cgtgaagtcc agcttataag                                                   20


<210> 18340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTTGTTT

<400> 18340
ataccatatt tcatgacata                                                   20


<210> 18341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAGGATT

<400> 18341
aacttgtttt tttttatttt                                                   20


<210> 18342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTAGATT

<400> 18342
gttttttttt atttttcagg                                                   20


<210> 18343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGTTT

<400> 18343
caatggaggg catcaattaa                                                   20


<210> 18344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTATGATT

<400> 18344
accttttctt cagaattaaa                                                   20


<210> 18345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGGTGCTT

<400> 18345
tcagaattaa agtatgattt                                                   20


<210> 18346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCTGTTT

<400> 18346
attactttac tgatatcaga                                                   20


<210> 18347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGCTT

<400> 18347
tgttcatagt cccatttata                                                   20


<210> 18348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGTTT

<400> 18348
gggtctctgc aacaatttct                                                   20


<210> 18349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGATT

<400> 18349
aaaggaattt ttcccccaaa                                                   20


<210> 18350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTAGATT

<400> 18350
attctaattt ttattacggc                                                   20


<210> 18351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGAGCTT

<400> 18351
cacaattcaa attaagtcat                                                   20


<210> 18352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGATT

<400> 18352
tctgaatttc tttcaataag                                                   20


<210> 18353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGCTT

<400> 18353
gttgaggaaa tcatacatct                                                   20


<210> 18354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTGGCTT

<400> 18354
ttgcttagct gttagtattt                                                   20


<210> 18355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCAAGTTT

<400> 18355
tagtatttgc tggcttacat                                                   20


<210> 18356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGCTT

<400> 18356
aaacaattgt atgctgcaca                                                   20


<210> 18357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGAGTTT

<400> 18357
gctgcacaaa gagcttcaaa                                                   20


<210> 18358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGTTT

<400> 18358
gagcttcaaa aggagttttt                                                   20


<210> 18359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGAGTTT

<400> 18359
ttacttgcat tttgacattt                                                   20


<210> 18360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGATT

<400> 18360
agtaattgac ccaggaattg                                                   20


<210> 18361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACAGCTT

<400> 18361
aagattgaat ttgataatct                                                   20


<210> 18362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGATT

<400> 18362
aaacaagagt tgagccaatg                                                   20


<210> 18363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGTTT

<400> 18363
ggatgccaaa aatctaaacg                                                   20


<210> 18364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAGGTTT

<400> 18364
aagccacagc tgacattata                                                   20


<210> 18365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGTGTTT

<400> 18365
aaggtttggg gaaatgtgca                                                   20


<210> 18366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACTGATT

<400> 18366
ggtcactaga gtgggacact                                                   20


<210> 18367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGGAGTTT

<400> 18367
acagggtgat gttcgggact                                                   20


<210> 18368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGCTT

<400> 18368
tttatcatta gcagactttc                                                   20


<210> 18369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTGGTTT

<400> 18369
ctggagtgag gcagttattg                                                   20


<210> 18370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACAGATT

<400> 18370
ggccactgga atgagaattt                                                   20


<210> 18371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCTGATT

<400> 18371
aatgagaatt tcacagattt                                                   20


<210> 18372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACTGATT

<400> 18372
gctgattttc agagcctgtg                                                   20


<210> 18373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGATGATT

<400> 18373
tctgagttaa tgataaataa                                                   20


<210> 18374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGGGCTT

<400> 18374
acctgttcac aacttgaaac                                                   20


<210> 18375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGAGTTT

<400> 18375
aagcacagtc tgagcatgta                                                   20


<210> 18376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTGGATT

<400> 18376
tgcagaataa caacaattac                                                   20


<210> 18377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGATT

<400> 18377
aggtattata agtaatctag                                                   20


<210> 18378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGATT

<400> 18378
aaagtatacg gtaggatgtg                                                   20


<210> 18379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGATT

<400> 18379
atgtaaagaa cttgagcatc                                                   20


<210> 18380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGCTT

<400> 18380
ttgtaattgt aattttctgc                                                   20


<210> 18381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGGGATT

<400> 18381
caaacctgct agaaagagga                                                   20


<210> 18382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGATT

<400> 18382
tagaaagagg atagggattg                                                   20


<210> 18383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGCGATT

<400> 18383
tttggctaat gttggcattt                                                   20


<210> 18384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTAGTTT

<400> 18384
caaaatcatt acatacattt                                                   20


<210> 18385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGGTGCTT

<400> 18385
atgggaacat ggaggaagaa                                                   20


<210> 18386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATCGATT

<400> 18386
tcctatagga atgcccccaa                                                   20


<210> 18387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTATGCTT

<400> 18387
ttaagctgag gttgagaaac                                                   20


<210> 18388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGAGGCTT

<400> 18388
cttagaccac aatttcacct                                                   20


<210> 18389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGCTT

<400> 18389
ttacttgctc ctttggctct                                                   20


<210> 18390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGTTT

<400> 18390
tgctcctttg gctctaattg                                                   20


<210> 18391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGTTT

<400> 18391
taaacggcct gagaggctgg                                                   20


<210> 18392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTAGGCTT

<400> 18392
tatatcttct gagaggtatt                                                   20


<210> 18393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACTGTTT

<400> 18393
atccaccaag gctaatcact                                                   20


<210> 18394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGTGATT

<400> 18394
gtaatcattc cagtgtcatc                                                   20


<210> 18395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTAAGCTT

<400> 18395
tgtcatccag tgattaagct                                                   20


<210> 18396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GACTGATT

<400> 18396
ctaactcatt ggaaaatatt                                                   20


<210> 18397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTATGATT

<400> 18397
gggtccagag gaaggtagat                                                   20


<210> 18398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGATT

<400> 18398
aaggtagatg tatgattttg                                                   20


<210> 18399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGATT

<400> 18399
ttaccaagtg aataaaactg                                                   20


<210> 18400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCGGGATT

<400> 18400
gctggaaatg gcagttgaac                                                   20


<210> 18401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCAAGATT

<400> 18401
tccagaagtg agatgagcat                                                   20


<210> 18402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGTGATT

<400> 18402
ggcctgccaa gttaatactc                                                   20


<210> 18403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAGGCTT

<400> 18403
atgagaggaa actaggagga                                                   20


<210> 18404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGTTT

<400> 18404
taaatccaat tttggacatc                                                   20


<210> 18405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATGGTTT

<400> 18405
attcctagtc ccaagaggct                                                   20


<210> 18406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACAGCTT

<400> 18406
catagtacaa aacatggcaa                                                   20


<210> 18407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTGGTTT

<400> 18407
ggaaacacaa ggggttagaa                                                   20


<210> 18408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCAGTTT

<400> 18408
taagttactt aactgtgtat                                                   20


<210> 18409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGATT

<400> 18409
catcggtaaa atgagtatga                                                   20


<210> 18410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGCTT

<400> 18410
agttaaataa actgacacat                                                   20


<210> 18411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGAGCTT

<400> 18411
ccaggataca agagagaaac                                                   20


<210> 18412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCCTGCTT

<400> 18412
ttgagcagtt gtgggagttg                                                   20


<210> 18413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGCTT

<400> 18413
tgggagttgc cctgcttcaa                                                   20


<210> 18414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGATT

<400> 18414
aagaaagatg acaccctcgg                                                   20


<210> 18415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGGGCTT

<400> 18415
tgacaccctc ggcattgatt                                                   20


<210> 18416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTGGCTT

<400> 18416
gttctatact tatgctattt                                                   20


<210> 18417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 18417
ctcctctctc cataactttt                                                   20


<210> 18418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGTTT

<400> 18418
tttatctgca acagaacttc                                                   20


<210> 18419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCAGGATT

<400> 18419
cacagctgtg tgtagcagag                                                   20


<210> 18420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGATGTTT

<400> 18420
aaaagataac attagaggaa                                                   20


<210> 18421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATGGCTT

<400> 18421
aactttaaaa tgcagaaata                                                   20


<210> 18422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGCTT

<400> 18422
gaatttttat cgatgactca                                                   20


<210> 18423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGAGTTT

<400> 18423
tttggcttta ttcagcagac                                                   20


<210> 18424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTAGTTT

<400> 18424
gtttagaaat tcaatcagtg                                                   20


<210> 18425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCACGCTT

<400> 18425
ccatcaggaa cacctagaag                                                   20


<210> 18426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCTGTTT

<400> 18426
ctagaagcca cgctttgttg                                                   20


<210> 18427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGCTGATT

<400> 18427
atataatgta tcacagaaaa                                                   20


<210> 18428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGTGTTT

<400> 18428
atttaggaag gtgggtgaga                                                   20


<210> 18429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGCTT

<400> 18429
ggagtccctg gcacctgaac                                                   20


<210> 18430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTGGCTT

<400> 18430
aggaaattat aagtccaaat                                                   20


<210> 18431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGATT

<400> 18431
actcttgtat gaacctgagt                                                   20


<210> 18432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGGGTTT

<400> 18432
aggcaggaca agcacctggc                                                   20


<210> 18433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACAGCTT

<400> 18433
tagggtttac tctacagtat                                                   20


<210> 18434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGGGTTT

<400> 18434
atttatatcg actatttgac                                                   20


<210> 18435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGTGTTT

<400> 18435
tacaagtgca ttttaccaaa                                                   20


<210> 18436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGATT

<400> 18436
tttaccaaat agtgtttcca                                                   20


<210> 18437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCAGTTT

<400> 18437
gattgcaaaa ctacttttca                                                   20


<210> 18438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACTGATT

<400> 18438
tttactttct caactactac                                                   20


<210> 18439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTGGTTT

<400> 18439
ctcaactact actactgatt                                                   20


<210> 18440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAGGCTT

<400> 18440
gtttttgaat tttttaaaaa                                                   20


<210> 18441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAACGTTT

<400> 18441
ttagtcctct aatcatatca                                                   20


<210> 18442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGATT

<400> 18442
gctcactgca gcctccacct                                                   20


<210> 18443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTAAGTTT

<400> 18443
gcaggcgcca caacacccgg                                                   20


<210> 18444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGATT

<400> 18444
cacctcagcc tcccaaagtg                                                   20


<210> 18445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTGGCTT

<400> 18445
tgcaggcatg agccgtcctg                                                   20


<210> 18446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGTTT

<400> 18446
tgagccgtcc tgcctggctt                                                   20


<210> 18447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGCTT

<400> 18447
tggggaacaa atggaaaata                                                   20


<210> 18448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTGGTTT

<400> 18448
ataatgacat ggtgagttac                                                   20


<210> 18449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAAGATT

<400> 18449
atgctctaaa atataaactg                                                   20


<210> 18450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGAGATT

<400> 18450
ttttcttacc aaaggtgaca                                                   20


<210> 18451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAAGTTT

<400> 18451
aaaggtgaca ttgagattta                                                   20


<210> 18452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGTGCTT

<400> 18452
acattgagat ttacaaagtt                                                   20


<210> 18453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGTTT

<400> 18453
gtttggtgct tgttaccaag                                                   20


<210> 18454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAGGCTT

<400> 18454
attgaagcta tgaccagaag                                                   20


<210> 18455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGAGCTT

<400> 18455
ctatgaccag aagtcaggct                                                   20


<210> 18456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTGGCTT

<400> 18456
aggctttgag ctttgagttc                                                   20


<210> 18457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGTTT

<400> 18457
attggcaaca atagacctgc                                                   20


<210> 18458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTAGTTT

<400> 18458
ctgcagatgt tttaaaaggc                                                   20


<210> 18459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGGAGATT

<400> 18459
aagatccaat tacaaagtct                                                   20


<210> 18460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCTGTTT

<400> 18460
aaggaaaaag gaagaggaat                                                   20


<210> 18461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGCTT

<400> 18461
catttcttta ttattttctt                                                   20


<210> 18462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGTTT

<400> 18462
tttcattcag gaaatacaag                                                   20


<210> 18463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCGGTTT

<400> 18463
tcaggaaata caagaaaggt                                                   20


<210> 18464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGTTT

<400> 18464
ggatattctg atctctctta                                                   20


<210> 18465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGTTT

<400> 18465
acatagggag ggttgcagac                                                   20


<210> 18466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 18466
tgtttctgca tgtgtggcat                                                   20


<210> 18467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGATT

<400> 18467
tgtttgtcaa aataataact                                                   20


<210> 18468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCTGATT

<400> 18468
tatgttgttc ccaagtcttg                                                   20


<210> 18469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATCGTTT

<400> 18469
atatattgca tttactttaa                                                   20


<210> 18470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGTTT

<400> 18470
tttagaatct ttgggctatt                                                   20


<210> 18471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCCTGTTT

<400> 18471
tgaatgccat atggagatgt                                                   20


<210> 18472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTAGCTT

<400> 18472
gccaatggtc aactactgca                                                   20


<210> 18473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCAAGTTT

<400> 18473
aggtgataat atctatagga                                                   20


<210> 18474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATGGCTT

<400> 18474
taattaagtg ttacaaacat                                                   20


<210> 18475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGCTT

<400> 18475
cattatggct ttaattatag                                                   20


<210> 18476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACTGTTT

<400> 18476
tttaattata gtgtggctta                                                   20


<210> 18477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGATT

<400> 18477
gtgtggctta aactgttttt                                                   20


<210> 18478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCACGTTT

<400> 18478
gtcagagaaa attttctacc                                                   20


<210> 18479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGCTT

<400> 18479
atctcccaat aaatgaattt                                                   20


<210> 18480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACAGATT

<400> 18480
gcatattcaa ctttggaaac                                                   20


<210> 18481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAAGCTT

<400> 18481
cctttgcata catccaccac                                                   20


<210> 18482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAACGTTT

<400> 18482
tccctacctt catgctgcaa                                                   20


<210> 18483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGAGTTT

<400> 18483
tttttagcac atagagtgca                                                   20


<210> 18484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCAGATT

<400> 18484
aaaactagca ttctttcaac                                                   20


<210> 18485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACCGATT

<400> 18485
ttggtgaggt gaaaaaagag                                                   20


<210> 18486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGCTT

<400> 18486
accgattttt ttgtcatata                                                   20


<210> 18487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTTGTTT

<400> 18487
atttttttgt catatacttt                                                   20


<210> 18488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGATT

<400> 18488
ttgttttata ggaaaaaaat                                                   20


<210> 18489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGTTT

<400> 18489
aacctattta gaattctaat                                                   20


<210> 18490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGCTT

<400> 18490
ttcaaaaaga aaacagaagt                                                   20


<210> 18491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAAGCTT

<400> 18491
aggcttcaca tataaaaacc                                                   20


<210> 18492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGCTT

<400> 18492
ttgatatttt atagaactag                                                   20


<210> 18493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAAGTTT

<400> 18493
aatgcttgta ttttcaaaat                                                   20


<210> 18494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGATT

<400> 18494
tgtattttca aaatagaagt                                                   20


<210> 18495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTAGATT

<400> 18495
gtttttgatt gatacaaaat                                                   20


<210> 18496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGTGATT

<400> 18496
aaatatttat tttatttcaa                                                   20


<210> 18497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGTTT

<400> 18497
aagtcaagca agagggaacc                                                   20


<210> 18498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACCTGATT

<400> 18498
attaagaact atgagaaaga                                                   20


<210> 18499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGTTT

<400> 18499
gaacctgatt tgaattgcag                                                   20


<210> 18500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACGGTTT

<400> 18500
atgtctttac ttctctaaac                                                   20


<210> 18501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGATGTTT

<400> 18501
ctactcaaga ggctgagaca                                                   20


<210> 18502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGCTT

<400> 18502
tcaagaggct gagacaggat                                                   20


<210> 18503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGAGATT

<400> 18503
cactcagcct gggagacaga                                                   20


<210> 18504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGTTT

<400> 18504
gcctgggaga cagagtgaga                                                   20


<210> 18505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGCTT

<400> 18505
atgtacaaat cattttatgt                                                   20


<210> 18506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACAGATT

<400> 18506
caattcttta cttgtgagat                                                   20


<210> 18507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGCTT

<400> 18507
tctttttaca ggaatccaaa                                                   20


<210> 18508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAGGCTT

<400> 18508
tcaaaatatg acattaataa                                                   20


<210> 18509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTCGCTT

<400> 18509
taaggacttg taatttgtac                                                   20


<210> 18510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGTTT

<400> 18510
ttcaagtcat ccgccattag                                                   20


<210> 18511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGCTT

<400> 18511
tgtttaacct tgcaagagta                                                   20


<210> 18512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTATGATT

<400> 18512
cacaatgaaa tttcctgctg                                                   20


<210> 18513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 18513
tccccacaac aaataatcta                                                   20


<210> 18514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTATGATT

<400> 18514
ccatcactga catcatagct                                                   20


<210> 18515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAAGCTT

<400> 18515
tgtcctttgt tatctttgcc                                                   20


<210> 18516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGAAGCTT

<400> 18516
tttttctcga ggaactaaat                                                   20


<210> 18517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTAGATT

<400> 18517
agacctcatg aaagaaataa                                                   20


<210> 18518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCTGATT

<400> 18518
aaagaaataa attagatttg                                                   20


<210> 18519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTGGCTT

<400> 18519
tgtgtataag atgggtatct                                                   20


<210> 18520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGATT

<400> 18520
aatgaatcaa gacatatata                                                   20


<210> 18521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAGGATT

<400> 18521
ctttcacaga atctctattt                                                   20


<210> 18522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCAGGTTT

<400> 18522
tagatcagga gtgggcagag                                                   20


<210> 18523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAAGCTT

<400> 18523
ggagtgggca gaggcaggtt                                                   20


<210> 18524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGGGTTT

<400> 18524
aacaaaaaaa agtagggaaa                                                   20


<210> 18525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGATT

<400> 18525
aaaagtaggg aaaaggggtt                                                   20


<210> 18526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGCTT

<400> 18526
ctgttgaaga tgaaggtatt                                                   20


<210> 18527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAAGTTT

<400> 18527
agagaatatc ttctaacgat                                                   20


<210> 18528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACTGTTT

<400> 18528
tatcatgtta ggaagaaagc                                                   20


<210> 18529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTAGCTT

<400> 18529
attactgaaa aacaactgaa                                                   20


<210> 18530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGCTT

<400> 18530
tgtctcattc tcctgctcct                                                   20


<210> 18531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTAAGATT

<400> 18531
cttttattta tctcagcaaa                                                   20


<210> 18532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCTGTTT

<400> 18532
gctgggaaaa aatatgtatc                                                   20


<210> 18533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGTTT

<400> 18533
gggactgcag agatacctgc                                                   20


<210> 18534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGTTT

<400> 18534
agaaaaacag acatttgcac                                                   20


<210> 18535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGTTT

<400> 18535
agttttgaga aaagcattta                                                   20


<210> 18536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGTGTTT

<400> 18536
tgatgctgaa ctaataagaa                                                   20


<210> 18537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGTTT

<400> 18537
ttttattttt ttgagtattc                                                   20


<210> 18538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAGGTTT

<400> 18538
aagctcttga cacccagggg                                                   20


<210> 18539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGTTT

<400> 18539
tgatgtacct catgtacaag                                                   20


<210> 18540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGTTT

<400> 18540
gtacctcatg tacaagatgt                                                   20


<210> 18541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGCTT

<400> 18541
atttagaatg cctctcaact                                                   20


<210> 18542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGCTT

<400> 18542
atggcaagat ggtaggttct                                                   20


<210> 18543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACGGTTT

<400> 18543
taccacctta gcacatgtgt                                                   20


<210> 18544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGATT

<400> 18544
ttagcacatg tgtaacggtt                                                   20


<210> 18545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGATT

<400> 18545
ttattttaac ccgctcattt                                                   20


<210> 18546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGATT

<400> 18546
aacatctaat caacaagggc                                                   20


<210> 18547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGCTT

<400> 18547
atcaacccta aaccctttcc                                                   20


<210> 18548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTAGGTTT

<400> 18548
tcacaatggt ctccaagtct                                                   20


<210> 18549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTGGCTT

<400> 18549
tcttctgtta aaaaatcatc                                                   20


<210> 18550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGCTT

<400> 18550
aaaatcatca gtggcttctc                                                   20


<210> 18551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGGGATT

<400> 18551
cagtggcttc tcaatagctt                                                   20


<210> 18552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGTTT

<400> 18552
cttccctcag gagccagtcc                                                   20


<210> 18553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCGTGCTT

<400> 18553
aattagccgg gcgtggtggc                                                   20


<210> 18554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATCGCTT

<400> 18554
tcggaaggct gaggcaggag                                                   20


<210> 18555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGGAGATT

<400> 18555
gaatcgcttg aacccaggag                                                   20


<210> 18556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGATT

<400> 18556
caaacaaaaa actcctctca                                                   20


<210> 18557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGTTT

<400> 18557
ttcaatttat gcattgaacc                                                   20


<210> 18558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGCTT

<400> 18558
tcaggaggct gaggcagaag                                                   20


<210> 18559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCAAGATT

<400> 18559
gaggcggagg ttgtggcgag                                                   20


<210> 18560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACATGCTT

<400> 18560
taaaaaataa aataaaatta                                                   20


<210> 18561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GACTGCTT

<400> 18561
accaaaaaca tttacaaaat                                                   20


<210> 18562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTATGATT

<400> 18562
ttccttatac tacaaaaatt                                                   20


<210> 18563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAAGCTT

<400> 18563
atggataatt taccagtaat                                                   20


<210> 18564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGAGATT

<400> 18564
tcaagctttt tatgtaagga                                                   20


<210> 18565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACAGCTT

<400> 18565
tgtctgggca ttctgccttt                                                   20


<210> 18566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTGGTTT

<400> 18566
tgtgtgtaat gtccccacca                                                   20


<210> 18567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCTGATT

<400> 18567
ctggtccatc ccttcatctc                                                   20


<210> 18568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAAGTTT

<400> 18568
ttcagaaatt taagaatatg                                                   20


<210> 18569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGATT

<400> 18569
aaatttaaga atatgagaag                                                   20


<210> 18570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGATT

<400> 18570
gtcactttta acttagtcat                                                   20


<210> 18571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCATGTTT

<400> 18571
taacttagtc atcaatgatt                                                   20


<210> 18572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCGGCTT

<400> 18572
ttaagtatat gtattacatc                                                   20


<210> 18573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGCTT

<400> 18573
taaaacatta ttttaacaaa                                                   20


<210> 18574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTAAGTTT

<400> 18574
gacacttaag acattcatat                                                   20


<210> 18575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCTGATT

<400> 18575
catatctaag ttttaaaaaa                                                   20


<210> 18576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGCTT

<400> 18576
aaaatctgat ttggcgacac                                                   20


<210> 18577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGTTT

<400> 18577
agtcagaaac attttcctta                                                   20


<210> 18578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATGGTTT

<400> 18578
tatcaaccac acaattactt                                                   20


<210> 18579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGCTT

<400> 18579
catacaactt atcatgaaaa                                                   20


<210> 18580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACATGTTT

<400> 18580
gatatgtgtc aaaggtgaaa                                                   20


<210> 18581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGATT

<400> 18581
ttaatcactt tatctaatgg                                                   20


<210> 18582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCTGATT

<400> 18582
tgctctggtt cagctgagca                                                   20


<210> 18583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGTTT

<400> 18583
ctgattacat ttcctgactt                                                   20


<210> 18584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTGGATT

<400> 18584
agctggtgga gaattccctg                                                   20


<210> 18585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTAGATT

<400> 18585
gtcattagtc ttgggggttg                                                   20


<210> 18586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACAGATT

<400> 18586
gctaacttta attactatag                                                   20


<210> 18587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGATT

<400> 18587
tttccccaaa ttcttaccct                                                   20


<210> 18588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTAGATT

<400> 18588
ccaaattctt acccttcttg                                                   20


<210> 18589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGAGTTT

<400> 18589
attggaaaca aatctcatta                                                   20


<210> 18590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGTTT

<400> 18590
caacctgata ccatctaaga                                                   20


<210> 18591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGTTT

<400> 18591
ttaaattcaa gtatagtgtg                                                   20


<210> 18592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGCGTTT

<400> 18592
tccctattgt cttcattcta                                                   20


<210> 18593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTAAGATT

<400> 18593
ctattataat gtgaatgaca                                                   20


<210> 18594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATGGATT

<400> 18594
gtagataaat ctatactact                                                   20


<210> 18595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGATGATT

<400> 18595
catggattta tctgacttat                                                   20


<210> 18596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGTTT

<400> 18596
ttaaagactg ttctattcaa                                                   20


<210> 18597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACATGCTT

<400> 18597
gttctattca ataaagtttt                                                   20


<210> 18598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCAAGCTT

<400> 18598
tagaaatatt atttaggaaa                                                   20


<210> 18599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGCTT

<400> 18599
caatcattaa ttaaagtaca                                                   20


<210> 18600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACTGATT

<400> 18600
ccttcattag actcttaatg                                                   20


<210> 18601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 18601
actcttaatg aactgattaa                                                   20


<210> 18602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGATT

<400> 18602
cattcaactg aaaacgggtc                                                   20


<210> 18603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGTGCTT

<400> 18603
gcaagtgaga tgtgccttgt                                                   20


<210> 18604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGTGTTT

<400> 18604
ttgttagtgc tttttaactt                                                   20


<210> 18605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACTGTTT

<400> 18605
ttgaagttgt tcaaataata                                                   20


<210> 18606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCAAGATT

<400> 18606
aataaactgt tttctctaaa                                                   20


<210> 18607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCTGTTT

<400> 18607
gatcgatatc tttccattgt                                                   20


<210> 18608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGCTT

<400> 18608
aatttctttt gaaaaaagat                                                   20


<210> 18609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCCTGTTT

<400> 18609
aaaatacaaa aatagtgagt                                                   20


<210> 18610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCAAGTTT

<400> 18610
atttagttgc ctaacaccaa                                                   20


<210> 18611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAGGTTT

<400> 18611
catgtctttg gtctgtcata                                                   20


<210> 18612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGTTT

<400> 18612
aacctgatgc tgacagcctc                                                   20


<210> 18613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTACGTTT

<400> 18613
tacattccag ctacattatt                                                   20


<210> 18614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACAGTTT

<400> 18614
cataatgttc cctttatctg                                                   20


<210> 18615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACCTGATT

<400> 18615
cagtttcaac tatcctgatc                                                   20


<210> 18616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTTGCTT

<400> 18616
actatcctga tcacctgatt                                                   20


<210> 18617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCAGCTT

<400> 18617
aaatataaat tcaacccttc                                                   20


<210> 18618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCTGCTT

<400> 18618
ctctttctcc catatctcca                                                   20


<210> 18619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCGGATT

<400> 18619
gctgccagca gtcccctaaa                                                   20


<210> 18620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGTGCTT

<400> 18620
ggatttttat cctacttcta                                                   20


<210> 18621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTAGATT

<400> 18621
catcacgcct gtctccttca                                                   20


<210> 18622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGCTT

<400> 18622
gcacatcata taaaattgtt                                                   20


<210> 18623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTAAGATT

<400> 18623
ttattattta acaaaatttt                                                   20


<210> 18624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGATT

<400> 18624
ttacaataat ccataactat                                                   20


<210> 18625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAGGATT

<400> 18625
gctgatatgt gcaaaaaata                                                   20


<210> 18626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACCTGTTT

<400> 18626
ataaggattc tgctattaca                                                   20


<210> 18627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCTGCTT

<400> 18627
tacaatttaa aaacaacact                                                   20


<210> 18628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAGGTTT

<400> 18628
ttaaaaacaa cactatctgc                                                   20


<210> 18629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTAGCTT

<400> 18629
atctgcttag gtttaattaa                                                   20


<210> 18630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGTTT

<400> 18630
cagccataaa caggaaggtt                                                   20


<210> 18631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGTTT

<400> 18631
acaatatggt ggacaccaac                                                   20


<210> 18632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGGGATT

<400> 18632
aaagtttaaa attctctaat                                                   20


<210> 18633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAAGTTT

<400> 18633
atttgggatt acacaaatcc                                                   20


<210> 18634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGTTT

<400> 18634
aacaaagcga tcaagtattt                                                   20


<210> 18635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTTGATT

<400> 18635
gcacagatac aatcctagat                                                   20


<210> 18636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGTTT

<400> 18636
aacttaattt ttgccattaa                                                   20


<210> 18637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCAGTTT

<400> 18637
tttgccatta aaatagttta                                                   20


<210> 18638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGCTT

<400> 18638
ttaaaatagt ttatgcagtt                                                   20


<210> 18639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGATT

<400> 18639
aacagggaga agctatactg                                                   20


<210> 18640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACTGATT

<400> 18640
ttaacctatt ccaagaaaat                                                   20


<210> 18641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 18641
tatatatata catactgaca                                                   20


<210> 18642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAACGTTT

<400> 18642
acttcataat ttgatattta                                                   20


<210> 18643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGTTT

<400> 18643
tattgaaata ttcattattt                                                   20


<210> 18644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGGGATT

<400> 18644
tcattatttt cttgtttgcc                                                   20


<210> 18645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCCAGTTT

<400> 18645
atttcttttt tttttctttt                                                   20


<210> 18646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTGGTTT

<400> 18646
ttaactttgt ctttactaaa                                                   20


<210> 18647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGTTT

<400> 18647
atttaccttt ttgtgcatat                                                   20


<210> 18648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGCAGTTT

<400> 18648
atatgttttc ccattgggag                                                   20


<210> 18649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGAGATT

<400> 18649
tgggaaacat aggcctagaa                                                   20


<210> 18650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GACAGATT

<400> 18650
tgagattttt tttttttttt                                                   20


<210> 18651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTGGATT

<400> 18651
gctcactata acctctgcct                                                   20


<210> 18652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGATT

<400> 18652
aacctctgcc tcctggattc                                                   20


<210> 18653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGGGTTT

<400> 18653
ttttgtattt ttagtagcga                                                   20


<210> 18654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGATT

<400> 18654
cgccttggcc tcccaaaatg                                                   20


<210> 18655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAGGTTT

<400> 18655
gccactgcgc ctggccaaaa                                                   20


<210> 18656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGCTGCTT

<400> 18656
tcttgtctga ggctgggtga                                                   20


<210> 18657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGTGTTT

<400> 18657
ctctgcctct tttcttttct                                                   20


<210> 18658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGATT

<400> 18658
tactgtacaa cattttttta                                                   20


<210> 18659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGAAGTTT

<400> 18659
ttatttagat ttttgtataa                                                   20


<210> 18660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATGGTTT

<400> 18660
ctctacattt ttacacacat                                                   20


<210> 18661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGATT

<400> 18661
catattttag aggaactatt                                                   20


<210> 18662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCAGGTTT

<400> 18662
tgaaaagtta ggtccaaatt                                                   20


<210> 18663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGTTT

<400> 18663
aaaataattc tctcactctt                                                   20


<210> 18664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGTTT

<400> 18664
accccttgtg tatccatcca                                                   20


<210> 18665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGTTT

<400> 18665
caaataatac cctatataaa                                                   20


<210> 18666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCAGCTT

<400> 18666
ataaagctac ttctttttat                                                   20


<210> 18667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTTGTTT

<400> 18667
cccacactgt agaacattta                                                   20


<210> 18668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTAGTTT

<400> 18668
gctacaataa ttatcttctc                                                   20


<210> 18669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAGGTTT

<400> 18669
ttaagttcag gggtacatgc                                                   20


<210> 18670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGGGTTT

<400> 18670
acacagggaa acttgtgtta                                                   20


<210> 18671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGTTT

<400> 18671
taagtgagga cattctcttg                                                   20


<210> 18672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGCTT

<400> 18672
cggtatttta tttgtaagac                                                   20


<210> 18673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGCGTTT

<400> 18673
ttgctgagtc ataattgtat                                                   20


<210> 18674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGAGATT

<400> 18674
tccatttgta accagagcag                                                   20


<210> 18675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATTGCTT

<400> 18675
tttgtaacca gagcagctga                                                   20


<210> 18676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTAGCTT

<400> 18676
cactcctcac tagtcaagaa                                                   20


<210> 18677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGCTT

<400> 18677
tccattcttt ggccatcgaa                                                   20


<210> 18678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGCTT

<400> 18678
tggccatcga ataaagcttg                                                   20


<210> 18679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGGGATT

<400> 18679
gctctcccca aacaatgtgt                                                   20


<210> 18680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATTGTTT

<400> 18680
tccccaaaca atgtgtcagg                                                   20


<210> 18681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCGGATT

<400> 18681
tgcctcagcc tcctgagtag                                                   20


<210> 18682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAGGTTT

<400> 18682
tttttgtacc tttagtagag                                                   20


<210> 18683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCAGCTT

<400> 18683
acctcatgtg atccacccat                                                   20


<210> 18684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGTTT

<400> 18684
aacttcttaa ttcttatcat                                                   20


<210> 18685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGCTT

<400> 18685
ttcatatcct cagatgccat                                                   20


<210> 18686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGTGTTT

<400> 18686
ccactttttt aatagactat                                                   20


<210> 18687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTAGCTT

<400> 18687
actcttaaca aaataataaa                                                   20


<210> 18688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTAAGTTT

<400> 18688
tatacaatac aaatattttt                                                   20


<210> 18689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCTGTTT

<400> 18689
tacaaatatt tttgtaagtt                                                   20


<210> 18690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 18690
tatttttgta agtttgctgt                                                   20


<210> 18691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGTTT

<400> 18691
agtttgctgt ttttgtttct                                                   20


<210> 18692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTAGTTT

<400> 18692
ttttgtttct tttggtttat                                                   20


<210> 18693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGTTT

<400> 18693
aatcctttct ccagtggctc                                                   20


<210> 18694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGGGTTT

<400> 18694
gtacttcata agtgtgatga                                                   20


<210> 18695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACATGTTT

<400> 18695
aaaaagaaaa caaaaccttc                                                   20


<210> 18696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCAGTTT

<400> 18696
accttcacat gttttcttct                                                   20


<210> 18697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGTTT

<400> 18697
atgttttctt ctagcagttt                                                   20


<210> 18698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGATT

<400> 18698
gtttgtatgt tattttaaat                                                   20


<210> 18699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCAGATT

<400> 18699
tgtacaattt cccaactaga                                                   20


<210> 18700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGGGATT

<400> 18700
aatttctatt tttattttca                                                   20


<210> 18701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGATT

<400> 18701
tcttttttta atacctcttc                                                   20


<210> 18702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCCTGATT

<400> 18702
atacttttca ttaaatactt                                                   20


<210> 18703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGCTT

<400> 18703
aaataattat tatttcttag                                                   20


<210> 18704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCAGTTT

<400> 18704
cttaatttgg tagatggcaa                                                   20


<210> 18705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTATGATT

<400> 18705
atagggacta tttctaaatt                                                   20


<210> 18706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGATT

<400> 18706
attctatgat tattaaaata                                                   20


<210> 18707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAAGTTT

<400> 18707
cttttaaaat atagtattcc                                                   20


<210> 18708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAAGTTT

<400> 18708
tcctcaagtt tataagaaat                                                   20


<210> 18709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACTGCTT

<400> 18709
tcaggaggct gaggcaggag                                                   20


<210> 18710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTGGATT

<400> 18710
agaactgctt gaacccggga                                                   20


<210> 18711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGTTT

<400> 18711
agaaaaaaaa aaaaagaaat                                                   20


<210> 18712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAAGATT

<400> 18712
gtgtattacc ctgggaaaac                                                   20


<210> 18713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAACGTTT

<400> 18713
caacatttgc tggcatatct                                                   20


<210> 18714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACATGATT

<400> 18714
ccacttccct caaaacatca                                                   20


<210> 18715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAGGTTT

<400> 18715
aactttggca ccaggcagac                                                   20


<210> 18716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCTGTTT

<400> 18716
ggcagactta ggtttgaatt                                                   20


<210> 18717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATGGTTT

<400> 18717
aagttatcat gtagaataga                                                   20


<210> 18718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCAAGATT

<400> 18718
cctaggctaa ataaataaca                                                   20


<210> 18719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTATGTTT

<400> 18719
atgtggagta tatttgttac                                                   20


<210> 18720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACATGTTT

<400> 18720
cctatgtttt atcttgccaa                                                   20


<210> 18721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATGGCTT

<400> 18721
tttatcttgc caaacatgtt                                                   20


<210> 18722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACTGCTT

<400> 18722
atgggttcac atcccatctc                                                   20


<210> 18723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTAGCTT

<400> 18723
acatcccatc tctactgctt                                                   20


<210> 18724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGTGATT

<400> 18724
tacattgtaa ctgttattat                                                   20


<210> 18725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTTGATT

<400> 18725
attttagcaa ctttcttcta                                                   20


<210> 18726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGCTT

<400> 18726
gttcttagga acgagaatat                                                   20


<210> 18727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGCTT

<400> 18727
atttgcttac tttataatag                                                   20


<210> 18728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGGAGCTT

<400> 18728
tacaaaacct tttcttctta                                                   20


<210> 18729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTATGCTT

<400> 18729
aatattttaa agactaaaat                                                   20


<210> 18730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTAGTTT

<400> 18730
gtcctgccaa tacaaagttc                                                   20


<210> 18731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTTGCTT

<400> 18731
cagtgtctac aggatgtggg                                                   20


<210> 18732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAGGTTT

<400> 18732
tatataaatt cttaaatcca                                                   20


<210> 18733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAAGATT

<400> 18733
ctgaacacac cgaggatgtt                                                   20


<210> 18734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGTTT

<400> 18734
aataaatgtg gcaagtgcat                                                   20


<210> 18735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGTTT

<400> 18735
aggactgagc agaattatgc                                                   20


<210> 18736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGAGCTT

<400> 18736
ttatgcaaaa gtttaaaata                                                   20


<210> 18737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGTTT

<400> 18737
agccagcaag atacaaggaa                                                   20


<210> 18738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAGGATT

<400> 18738
aaaatgctct agcatgagtc                                                   20


<210> 18739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGATT

<400> 18739
aaaactagtg acatctactc                                                   20


<210> 18740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGTTT

<400> 18740
cataagattt ttgatgaaga                                                   20


<210> 18741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTGGTTT

<400> 18741
ttagcaaagg aagggggtaa                                                   20


<210> 18742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACAGTTT

<400> 18742
tggtttgagg agtctaaagg                                                   20


<210> 18743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGAGTTT

<400> 18743
agtactatgg tataaataac                                                   20


<210> 18744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGTTT

<400> 18744
atgttcatag atatgacttc                                                   20


<210> 18745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGATT

<400> 18745
ctctctcttg gaactaaagg                                                   20


<210> 18746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGTTT

<400> 18746
atatgatgaa actcatgtga                                                   20


<210> 18747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAGGATT

<400> 18747
tcagaacctc acagatataa                                                   20


<210> 18748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGTTT

<400> 18748
caaatttata ttccagaagg                                                   20


<210> 18749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGCTT

<400> 18749
aggaagtgtt ttgcctaaac                                                   20


<210> 18750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGAGGCTT

<400> 18750
taggaatata actttgacca                                                   20


<210> 18751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTGGATT

<400> 18751
atataacttt gaccaggagg                                                   20


<210> 18752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGTGCTT

<400> 18752
tcacaacaat tcaatgacaa                                                   20


<210> 18753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGAGTTT

<400> 18753
gcaaaattta cttagtgacc                                                   20


<210> 18754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGCTT

<400> 18754
ataaatagtc accatttttc                                                   20


<210> 18755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAGGATT

<400> 18755
cctaggggac ttaacctcca                                                   20


<210> 18756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGTTT

<400> 18756
ataaacacta accttaaaac                                                   20


<210> 18757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGAGATT

<400> 18757
tactaaaaat taacagagag                                                   20


<210> 18758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTTGCTT

<400> 18758
cagagagagg agatttttga                                                   20


<210> 18759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTAAGATT

<400> 18759
cttgctttat taaaataaat                                                   20


<210> 18760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATAGCTT

<400> 18760
cttgaccgtt gagaaaacaa                                                   20


<210> 18761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 18761
ctttcttact cattaattca                                                   20


<210> 18762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGATT

<400> 18762
aagccttgta aaatggtctg                                                   20


<210> 18763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCTTGTTT

<400> 18763
acaactacag cacaatgaat                                                   20


<210> 18764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGATT

<400> 18764
ctacagcaca atgaatcctt                                                   20


<210> 18765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTAGGATT

<400> 18765
cttgtttgat ttaatcatat                                                   20


<210> 18766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGTTT

<400> 18766
gtatatttat acaacaactc                                                   20


<210> 18767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTAGATT

<400> 18767
tagggaaaaa tcttcgagac                                                   20


<210> 18768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTGGATT

<400> 18768
caaaagaaaa aaagagctga                                                   20


<210> 18769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGGGATT

<400> 18769
ttgcaaatca tatatctgat                                                   20


<210> 18770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCAGATT

<400> 18770
tcctcaacaa aaaataaaca                                                   20


<210> 18771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGATT

<400> 18771
caagcagatt aaaaatgaac                                                   20


<210> 18772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGTTT

<400> 18772
ttcacacttg gtcggatggt                                                   20


<210> 18773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATTGTTT

<400> 18773
ggaagagagg agtgtggagt                                                   20


<210> 18774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCGAGTTT

<400> 18774
gagtcattgt ttaatagtta                                                   20


<210> 18775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGTTT

<400> 18775
ttgtttaata gttaccgagt                                                   20


<210> 18776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGCTT

<400> 18776
ggtgatcgtg tacaacatga                                                   20


<210> 18777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCGTGTTT

<400> 18777
ataaattttt aaattcacta                                                   20


<210> 18778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCTGTTT

<400> 18778
acatgcggtg tctccttggt                                                   20


<210> 18779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAAGTTT

<400> 18779
atattactgt actcccacca                                                   20


<210> 18780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTGGTTT

<400> 18780
aaacttctca aacatttttt                                                   20


<210> 18781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTGGTTT

<400> 18781
cccatgctgg taattttagc                                                   20


<210> 18782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGCTT

<400> 18782
aatcaagaaa aaccctcatc                                                   20


<210> 18783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTGGTTT

<400> 18783
gctgtctgta tttcaaccat                                                   20


<210> 18784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGCTT

<400> 18784
tatttcaacc atgctggttt                                                   20


<210> 18785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGGGCTT

<400> 18785
taaatacatc aaatatgcct                                                   20


<210> 18786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCTGTTT

<400> 18786
tgccttaggg cttttgcaat                                                   20


<210> 18787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGATT

<400> 18787
attgctgttt tttgtgacta                                                   20


<210> 18788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTTGTTT

<400> 18788
tgtgactaga atgattcttc                                                   20


<210> 18789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTAGTTT

<400> 18789
tcagttgttt agctagctcc                                                   20


<210> 18790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCCTGTTT

<400> 18790
ctccttctct caattctctg                                                   20


<210> 18791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGTTT

<400> 18791
ctcaattctc tgtcctgttt                                                   20


<210> 18792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGCTT

<400> 18792
aaagagggaa ggaaagaagg                                                   20


<210> 18793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCCGCTT

<400> 18793
ctggcctgga gggactcagc                                                   20


<210> 18794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGATT

<400> 18794
gaggccaact agaccggatc                                                   20


<210> 18795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGCTT

<400> 18795
aagataaatc agttggaaat                                                   20


<210> 18796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGTTT

<400> 18796
gttggaaatt tcagctttaa                                                   20


<210> 18797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAAGTTT

<400> 18797
taagcatatc tgtcactgtc                                                   20


<210> 18798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTAAGATT

<400> 18798
catgcatgct gtcacaaata                                                   20


<210> 18799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTTGTTT

<400> 18799
tatctgttga tgatcatttg                                                   20


<210> 18800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGAGATT

<400> 18800
acagaagtgc atatatctct                                                   20


<210> 18801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGATT

<400> 18801
gtgcatatat ctctttgaga                                                   20


<210> 18802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGCTT

<400> 18802
acattcccac caacagtgga                                                   20


<210> 18803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGATT

<400> 18803
cagccatctt aacaggtgtg                                                   20


<210> 18804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGATT

<400> 18804
accaatccac aaatcactaa                                                   20


<210> 18805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATGGTTT

<400> 18805
aactcaaggg ccaaatttcc                                                   20


<210> 18806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTAGTTT

<400> 18806
ataaacataa tgtaaaataa                                                   20


<210> 18807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACTGTTT

<400> 18807
aaaataaatt agttttccaa                                                   20


<210> 18808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGATT

<400> 18808
agtcttcatg acaataagta                                                   20


<210> 18809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAGGTTT

<400> 18809
atgacaataa gtactgtgat                                                   20


<210> 18810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGCTT

<400> 18810
tcttatcctg cacaagatca                                                   20


<210> 18811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCCTGTTT

<400> 18811
tcaacgtgtg taacttcatt                                                   20


<210> 18812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATAGTTT

<400> 18812
ggtgctggcc accatgcctg                                                   20


<210> 18813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGGGTTT

<400> 18813
tgtatttttt ttagtagaga                                                   20


<210> 18814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCTGGATT

<400> 18814
ctgcctcagc cttccaaagt                                                   20


<210> 18815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGTTT

<400> 18815
ggggaaggcc tttttcccat                                                   20


<210> 18816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTTGTTT

<400> 18816
gtcatccatc tttctttttt                                                   20


<210> 18817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACATGATT

<400> 18817
gttttctatt agctgtaatt                                                   20


<210> 18818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTATGTTT

<400> 18818
agctgtaatt acatgattta                                                   20


<210> 18819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGATT

<400> 18819
gtaattacat gatttagtat                                                   20


<210> 18820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGCTT

<400> 18820
agggttaaac atatttgata                                                   20


<210> 18821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGATT

<400> 18821
caaacgtatt cttggaatat                                                   20


<210> 18822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAAGTTT

<400> 18822
aaaagaaatg tgtatgttat                                                   20


<210> 18823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAGGATT

<400> 18823
ctcacctcaa atggtggtca                                                   20


<210> 18824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTGGCTT

<400> 18824
cataattgct ggccttgcac                                                   20


<210> 18825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGCTT

<400> 18825
tcgggaggct gaggcaggag                                                   20


<210> 18826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGATT

<400> 18826
aaaaaaaaaa aaagaatgca                                                   20


<210> 18827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGCTGTTT

<400> 18827
catgtgtaag acactaaagt                                                   20


<210> 18828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGCTT

<400> 18828
ttgaactcaa atttatttat                                                   20


<210> 18829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGGGATT

<400> 18829
aaagtctgtc agctgatctc                                                   20


<210> 18830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCAAGTTT

<400> 18830
cctacctgaa ttaccatgag                                                   20


<210> 18831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAAGATT

<400> 18831
ttccatgcaa agatcattta                                                   20


<210> 18832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGAGCTT

<400> 18832
ttgaaagaat agtcatttag                                                   20


<210> 18833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACAGATT

<400> 18833
aattttaatt tttttgtaga                                                   20


<210> 18834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGGGATT

<400> 18834
agcctcggcc tcccaaagtg                                                   20


<210> 18835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCCTGTTT

<400> 18835
gaaacatttt tctcattttt                                                   20


<210> 18836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATGGATT

<400> 18836
ttccctgttt tactcatctg                                                   20


<210> 18837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTGGATT

<400> 18837
catattttta aaataattac                                                   20


<210> 18838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGCTT

<400> 18838
aatgggctga gcgcggtggc                                                   20


<210> 18839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGAGATT

<400> 18839
ggcgggcgga tcactaggtc                                                   20


<210> 18840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGGAGCTT

<400> 18840
aatggtgtga acccaggacg                                                   20


<210> 18841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGTTT

<400> 18841
ttttattaaa aatcttatgg                                                   20


<210> 18842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCATGCTT

<400> 18842
tttaatactt atattttaat                                                   20


<210> 18843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGTTT

<400> 18843
attttccaat tatttgtact                                                   20


<210> 18844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGAGCTT

<400> 18844
tgaacaatcc taggtgcaat                                                   20


<210> 18845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGATT

<400> 18845
gagctttatt gtattttgat                                                   20


<210> 18846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAAGCTT

<400> 18846
gtattttgat aaatgattca                                                   20


<210> 18847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAGGTTT

<400> 18847
aaattacagt taaagtaacg                                                   20


<210> 18848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGCTT

<400> 18848
agaaacaaca acaacatatt                                                   20


<210> 18849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACGGTTT

<400> 18849
ttaaaaagag acgtggaaag                                                   20


<210> 18850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGCAGATT

<400> 18850
gtcaattcaa acttgtctgt                                                   20


<210> 18851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTATGCTT

<400> 18851
tcaaacttgt ctgtggcaga                                                   20


<210> 18852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGGGTTT

<400> 18852
catttttcct caccacccag                                                   20


<210> 18853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GATGGCTT

<400> 18853
acctttagct gccaagagct                                                   20


<210> 18854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATCAGTTT

<400> 18854
gctacataaa aaaatcatta                                                   20


<210> 18855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTTGTTT

<400> 18855
caaatgttaa tagcaaaact                                                   20


<210> 18856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGTTT

<400> 18856
tgttaatagc aaaactagtt                                                   20


<210> 18857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGTTT

<400> 18857
gacacaatca tttatgagca                                                   20


<210> 18858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAATGCTT

<400> 18858
ctctctgaac cttccttaga                                                   20


<210> 18859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTATGTTT

<400> 18859
aactgagctc acataagcat                                                   20


<210> 18860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACAGATT

<400> 18860
ctcaaatttc tgttagatga                                                   20


<210> 18861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGATT

<400> 18861
aaacctaaca aggttatcat                                                   20


<210> 18862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTAGTTT

<400> 18862
ttggagtcac ttataaccat                                                   20


<210> 18863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGCTT

<400> 18863
catgatattg taaaaatact                                                   20


<210> 18864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCATGTTT

<400> 18864
aaaaaataga atcacaaaat                                                   20


<210> 18865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGCTT

<400> 18865
aattcatgtt tccagggtta                                                   20


<210> 18866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGAGATT

<400> 18866
caaaacaaaa aaacctcgag                                                   20


<210> 18867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAAAGTTT

<400> 18867
aaaaacctcg agttgagatt                                                   20


<210> 18868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGTTT

<400> 18868
gaaaaggcct taaagagtgc                                                   20


<210> 18869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGTTT

<400> 18869
ttaaagagtg ctattgtttc                                                   20


<210> 18870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCATGTTT

<400> 18870
gctaattggt ctctgtgttg                                                   20


<210> 18871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAATGTTT

<400> 18871
ttttaaatgc agttgtgagc                                                   20


<210> 18872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGCTT

<400> 18872
tgttagggga gacaggatgg                                                   20


<210> 18873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGAGATT

<400> 18873
gggagaaaat tacagaagtg                                                   20


<210> 18874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCAGGATT

<400> 18874
agattgatat ggaggctgtg                                                   20


<210> 18875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGTTT

<400> 18875
agacgtatga tgaaatagaa                                                   20


<210> 18876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAAGATT

<400> 18876
aatagaaata agtttgggag                                                   20


<210> 18877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGGTGATT

<400> 18877
ataaggaaga gagcaatcaa                                                   20


<210> 18878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGAGTTT

<400> 18878
tgggaggaaa gaatctgaga                                                   20


<210> 18879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATAGATT

<400> 18879
ggaatagaaa ttggataaaa                                                   20


<210> 18880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGTTGATT

<400> 18880
tccttgccac agagaaagtg                                                   20


<210> 18881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TACTGATT

<400> 18881
atattaaata aatagaaccc                                                   20


<210> 18882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 18882
ttgctcttct gaatttattt                                                   20


<210> 18883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGCTT

<400> 18883
tttatttatt tgtttatcta                                                   20


<210> 18884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCATGATT

<400> 18884
gcattaccac agaagggctc                                                   20


<210> 18885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGCTT

<400> 18885
cctaggggaa aggaggccca                                                   20


<210> 18886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGTGGCTT

<400> 18886
actgagtccc acaactgcac                                                   20


<210> 18887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGAGTTT

<400> 18887
atcaaatacc atattctgtc                                                   20


<210> 18888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTAGCTT

<400> 18888
cgacacaggg atcagataag                                                   20


<210> 18889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AACAGTTT

<400> 18889
gaagaatttg caataaaatg                                                   20


<210> 18890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTGGATT

<400> 18890
ataaaatgaa cagtttaata                                                   20


<210> 18891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGTTT

<400> 18891
tgaacagttt aataattgga                                                   20


<210> 18892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCAGTTT

<400> 18892
tttaataatt ggatttggtt                                                   20


<210> 18893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAGGTTT

<400> 18893
tggtttgcag tttatataaa                                                   20


<210> 18894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGTTT

<400> 18894
gaaatagaaa agaataataa                                                   20


<210> 18895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAAAGCTT

<400> 18895
tgacaagcta tcacttcctt                                                   20


<210> 18896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGATT

<400> 18896
atcacttcct tgaaagctta                                                   20


<210> 18897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTGGCTT

<400> 18897
tccttgaaag cttactttga                                                   20


<210> 18898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTAGCTT

<400> 18898
ttggctttta tcttactgac                                                   20


<210> 18899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTAAGTTT

<400> 18899
ctagcttctt aaaaaccccc                                                   20


<210> 18900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 18900
aaaaactaaa ataatgagtg                                                   20


<210> 18901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGTTT

<400> 18901
ataatcacaa aaactggcat                                                   20


<210> 18902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTAGTTT

<400> 18902
caaaaactgg cattaatgtt                                                   20


<210> 18903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGATT

<400> 18903
ttaatgtttc tagtttcttg                                                   20


<210> 18904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGAGTTT

<400> 18904
ccattttttc ctaaaagtaa                                                   20


<210> 18905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAAGGATT

<400> 18905
ttgaattcga taaaaagtta                                                   20


<210> 18906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGTGCTT

<400> 18906
cttttctgaa tttcactata                                                   20


<210> 18907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGTTT

<400> 18907
agagctgtcc tgtcaattat                                                   20


<210> 18908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTCAGCTT

<400> 18908
tgctaagctg gttctgcacg                                                   20


<210> 18909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACATGCTT

<400> 18909
ttgcagatgg gaaatacagc                                                   20


<210> 18910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CACAGTTT

<400> 18910
gcattgctac ccttcctttc                                                   20


<210> 18911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTACGCTT

<400> 18911
ctgcccagct atcgaaataa                                                   20


<210> 18912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAAGCTT

<400> 18912
ccattgctgg aaccacccgg                                                   20


<210> 18913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGGGCTT

<400> 18913
gcgagcacgg gcgaaagacc                                                   20


<210> 18914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGCTGCTT

<400> 18914
cttccccggc gctctctcag                                                   20


<210> 18915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CGCCGCTT

<400> 18915
cgcctccccg agggcagctg                                                   20


<210> 18916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGTGTTT

<400> 18916
acccattggg tggggcgtgt                                                   20


<210> 18917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAATGTTT

<400> 18917
tcctgctcag cagaatcggc                                                   20


<210> 18918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGTGGCTT

<400> 18918
gtttccgaga agtcactttg                                                   20


<210> 18919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTGGTTT

<400> 18919
ctgaagagtc taggctggga                                                   20


<210> 18920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TAGGGCTT

<400> 18920
ctgggaattg gtttcttccg                                                   20


<210> 18921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTATGTTT

<400> 18921
gctcaagacc ggtatctagg                                                   20


<210> 18922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCTGTTT

<400> 18922
accggtatct aggctatgtt                                                   20


<210> 18923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GGCTGCTT

<400> 18923
ggaaagaaac gtggggaaaa                                                   20


<210> 18924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACCCGATT

<400> 18924
gctgcttttc cagacctggg                                                   20


<210> 18925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTGCGCTT

<400> 18925
attttgtgtg gagtgtgtgc                                                   20


<210> 18926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGCTT

<400> 18926
tagtgacggg cacttttatt                                                   20


<210> 18927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGATGCTT

<400> 18927
cacaccttct atcatggaaa                                                   20


<210> 18928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGCTGCTT

<400> 18928
tcccagggtc tacttttccc                                                   20


<210> 18929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTTGCTT

<400> 18929
ctacttttcc ctgctgcttt                                                   20


<210> 18930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGAGATT

<400> 18930
ccctgctgct ttctttgctt                                                   20


<210> 18931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGGGGCTT

<400> 18931
tttgcttctg agatttgtcc                                                   20


<210> 18932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCCTGATT

<400> 18932
tggacaaatc gccttctctt                                                   20


<210> 18933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAGAGATT

<400> 18933
gcaaaactga agggagggta                                                   20


<210> 18934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAGGTTT

<400> 18934
taaaattaat gaacttactt                                                   20


<210> 18935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGTTT

<400> 18935
actgatcatt ttactgtctt                                                   20


<210> 18936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTCAGATT

<400> 18936
ataatacaga atatagccct                                                   20


<210> 18937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGCTT

<400> 18937
ttgactcctt tcacttagca                                                   20


<210> 18938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGTTT

<400> 18938
ctttcactta gcaatatgct                                                   20


<210> 18939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATGGCTT

<400> 18939
atatgctttt agttttcctc                                                   20


<210> 18940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATAGCTT

<400> 18940
agttttcctc catggctttt                                                   20


<210> 18941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATAGTTT

<400> 18941
attccattga ctggtggtac                                                   20


<210> 18942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTTGTTT

<400> 18942
cattcaccta ctgaaggaca                                                   20


<210> 18943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGCTT

<400> 18943
cacctactga aggacatctt                                                   20


<210> 18944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CCAAGTTT

<400> 18944
gaaggacatc ttgtttgctt                                                   20


<210> 18945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACATGTTT

<400> 18945
ttgtgaaggt tactgtgtgg                                                   20


<210> 18946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTATGTTT

<400> 18946
tgctggatca tatggtgaga                                                   20


<210> 18947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTAGTTT

<400> 18947
gatcatatgg tgagagtatg                                                   20


<210> 18948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTGGATT

<400> 18948
gaacttgata tcatcagtgt                                                   20


<210> 18949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGATT

<400> 18949
ttgttgatac cataagtgtt                                                   20


<210> 18950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATATGCTT

<400> 18950
atgatgtgga tcaccttttt                                                   20


<210> 18951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGAGTTT

<400> 18951
ggttatttct tttcttgttg                                                   20


<210> 18952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTAAGCTT

<400> 18952
tcttttcttg ttgttgagtt                                                   20


<210> 18953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTGGCTT

<400> 18953
tttgcaaata tttatctaac                                                   20


<210> 18954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTCCGTTT

<400> 18954
ttatctaaca ctggcttgtt                                                   20


<210> 18955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAAGTTT

<400> 18955
gttgtccgtt tttgcagagc                                                   20


<210> 18956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATAGATT

<400> 18956
accttagcaa ttatgtctct                                                   20


<210> 18957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GCAGGATT

<400> 18957
gtctgactga gggatccctt                                                   20


<210> 18958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGCTGTTT

<400> 18958
ttcctagtct acagaacatt                                                   20


<210> 18959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTGTGTTT

<400> 18959
gtctacagaa cattagctgt                                                   20


<210> 18960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTTGGTTT

<400> 18960
ggcagcccta gaaattttat                                                   20


<210> 18961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTACGTTT

<400> 18961
gatgtagaca taagtagatg                                                   20


<210> 18962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTAGGCTT

<400> 18962
gtacgtttaa aatttaaagg                                                   20


<210> 18963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAAGTTT

<400> 18963
actgcaattt tcaaaactgt                                                   20


<210> 18964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGTTT

<400> 18964
taaaattaat acaatactga                                                   20


<210> 18965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTTTGTTT

<400> 18965
attaatacaa tactgaaaga                                                   20


<210> 18966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATAGGATT

<400> 18966
gtttgttttt ctctaattaa                                                   20


<210> 18967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACAAGTTT

<400> 18967
gaaaatagaa gaataaagtt                                                   20


<210> 18968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GTAGGATT

<400> 18968
tgtgtataca tagctaaaaa                                                   20


<210> 18969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGAAGATT

<400> 18969
aaaagaaata gaatatacaa                                                   20


<210> 18970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CATAGATT

<400> 18970
atacaatgaa gattatcaga                                                   20


<210> 18971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TGATGCTT

<400> 18971
ggagtgatga gatgggcaaa                                                   20


<210> 18972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGAGGTTT

<400> 18972
taatgaaaca actgaagaaa                                                   20


<210> 18973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: GAGTGTTT

<400> 18973
tcctaaatgt attggcatct                                                   20


<210> 18974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTGGATT

<400> 18974
gctcgtctaa tttgacgtgg                                                   20


<210> 18975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAATGTTT

<400> 18975
aaactgatgt gaagaaaaat                                                   20


<210> 18976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AGATGCTT

<400> 18976
tgttttgtct tgcatgtagt                                                   20


<210> 18977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATTGATT

<400> 18977
agatgcttag taagtatatt                                                   20


<210> 18978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AATGGTTT

<400> 18978
gatgggtccc ttaccctaac                                                   20


<210> 18979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATGTGCTT

<400> 18979
taacaatggt tttgctgata                                                   20


<210> 18980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ACTAGTTT

<400> 18980
ggggacaaaa tatatgaaac                                                   20


<210> 18981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CTGTGATT

<400> 18981
agaagagaaa gaaagtgagg                                                   20


<210> 18982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: CAAAGTTT

<400> 18982
gattgtctct gcatactaca                                                   20


<210> 18983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: AAGAGTTT

<400> 18983
aacatgaaga gccagaaaat                                                   20


<210> 18984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: ATTTGTTT

<400> 18984
gataggctga gggagctaga                                                   20


<210> 18985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCAAGTTT

<400> 18985
gagatctgta gaaagagacc                                                   20


<210> 18986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TTTTGCTT

<400> 18986
tgtagaaaga gacctcaagt                                                   20


<210> 18987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TATTGCTT

<400> 18987
ttagtcttta tggtatagcc                                                   20


<210> 18988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (+) strand; PAM type: NNNNGHTT; 
      PAM sequence: TCTGGATT

<400> 18988
ttaactttaa ctaacgttgc                                                   20


<210> 18989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 18989
accgacatta ccttagctat                                                   20


<210> 18990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 18990
atggataacc gacattacct                                                   20


<210> 18991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 18991
gtctataaaa gtatgaatca                                                   20


<210> 18992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 18992
atctctgaca atgtctataa                                                   20


<210> 18993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 18993
cagggggaca aaatcttccc                                                   20


<210> 18994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 18994
ctttgctaaa tgttctcagg                                                   20


<210> 18995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 18995
tctttgctaa atgttctcag                                                   20


<210> 18996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 18996
atctttgcta aatgttctca                                                   20


<210> 18997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 18997
catctttgct aaatgttctc                                                   20


<210> 18998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 18998
ccatctttgc taaatgttct                                                   20


<210> 18999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 18999
aataaacatt cctaattcca                                                   20


<210> 19000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19000
gatcactggt ctctaacctc                                                   20


<210> 19001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19001
gggatgttta gcacgatcac                                                   20


<210> 19002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19002
cctgtgcatg gtgggatgtt                                                   20


<210> 19003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19003
gtggctgtcc tgtgcatggt                                                   20


<210> 19004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19004
agtggctgtc ctgtgcatgg                                                   20


<210> 19005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19005
gtgagtggct gtcctgtgca                                                   20


<210> 19006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19006
ggataattct ttgttgtgag                                                   20


<210> 19007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19007
gctggataat tctttgttgt                                                   20


<210> 19008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19008
ggcaatcttg atatttgagc                                                   20


<210> 19009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19009
tattggcaat cttgatattt                                                   20


<210> 19010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19010
aggcctgagt ttctcaatat                                                   20


<210> 19011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19011
catttatttc tctaaggcct                                                   20


<210> 19012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19012
atcagacatt tatttctcta                                                   20


<210> 19013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19013
aatcagacat ttatttctct                                                   20


<210> 19014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19014
tatacattct acattaaaat                                                   20


<210> 19015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19015
ataatgtcaa gtaggaaata                                                   20


<210> 19016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19016
aaacagagat aatgtcaagt                                                   20


<210> 19017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19017
aaaacagaga taatgtcaag                                                   20


<210> 19018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19018
aaaaaaacag agataatgtc                                                   20


<210> 19019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19019
aacaaagtag aaaaaaaaca                                                   20


<210> 19020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19020
ttaacaaagt agaaaaaaaa                                                   20


<210> 19021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19021
cctctatagc tttaacaaag                                                   20


<210> 19022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19022
tttcctctat agctttaaca                                                   20


<210> 19023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19023
ttaaaagtgt ttttcctcta                                                   20


<210> 19024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19024
tttttgaagg actaagttaa                                                   20


<210> 19025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19025
actggcattt ttgaaggact                                                   20


<210> 19026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19026
tagaaaactg gcatttttga                                                   20


<210> 19027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19027
atagaaaact ggcatttttg                                                   20


<210> 19028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19028
ataaaattag tatagaaaac                                                   20


<210> 19029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19029
ctcacaaaat aaaattagta                                                   20


<210> 19030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19030
cactgctcac aaaataaaat                                                   20


<210> 19031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19031
ctttcacatg gtaagttgag                                                   20


<210> 19032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19032
tgtctttcac atggtaagtt                                                   20


<210> 19033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19033
atacatgtct ttcacatggt                                                   20


<210> 19034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19034
gactatacat gtctttcaca                                                   20


<210> 19035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19035
cagtgctttc tggcctgaga                                                   20


<210> 19036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19036
gccagtgctt tctggcctga                                                   20


<210> 19037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19037
gtgccagtgc tttctggcct                                                   20


<210> 19038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19038
tatacagtgc cagtgctttc                                                   20


<210> 19039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19039
cttacattct tatacagtgc                                                   20


<210> 19040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19040
tgtattctta cattcttata                                                   20


<210> 19041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19041
ggatcttctc aacaaaagta                                                   20


<210> 19042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19042
ttgcaggatc ttctcaacaa                                                   20


<210> 19043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19043
atagttttct ttctgtttgc                                                   20


<210> 19044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19044
aatagttttc tttctgtttg                                                   20


<210> 19045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19045
tctgtgtgct tcagcctcaa                                                   20


<210> 19046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19046
ctatcttaat ctgtgtgctt                                                   20


<210> 19047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19047
tttccagccc tacaccatgt                                                   20


<210> 19048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19048
tacaagttct acaagctttc                                                   20


<210> 19049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19049
ttactgtcta caagttctac                                                   20


<210> 19050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19050
tctatactat tactgtctac                                                   20


<210> 19051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19051
aaattctaaa atcctcagca                                                   20


<210> 19052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19052
atgataaatt ctaaaatcct                                                   20


<210> 19053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 19053
taaaattttg ggtcattttc                                                   20


<210> 19054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19054
atttccctgc ttaaaatttt                                                   20


<210> 19055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19055
catttccctg cttaaaattt                                                   20


<210> 19056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19056
tagccagagt ggattttatg                                                   20


<210> 19057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19057
gtagccagag tggattttat                                                   20


<210> 19058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19058
tctcagtaca gtagccagag                                                   20


<210> 19059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19059
tattctcagt acagtagcca                                                   20


<210> 19060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19060
tctattctca gtacagtagc                                                   20


<210> 19061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19061
caaatctatt ctcagtacag                                                   20


<210> 19062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19062
ttccaaatct attctcagta                                                   20


<210> 19063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19063
ctcacttcca aatctattct                                                   20


<210> 19064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19064
accaccttta acctctttat                                                   20


<210> 19065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19065
ccgcatttat tcaccaagac                                                   20


<210> 19066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19066
accctccgca tttattcacc                                                   20


<210> 19067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19067
gattagtacc accattcatc                                                   20


<210> 19068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19068
acatcttcct tctcattgat                                                   20


<210> 19069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19069
taagggacaa ctgtatatca                                                   20


<210> 19070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19070
caatccccag cagatactaa                                                   20


<210> 19071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19071
ccaatcccca gcagatacta                                                   20


<210> 19072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19072
gccaatcccc agcagatact                                                   20


<210> 19073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19073
gtccagaagc caatccccag                                                   20


<210> 19074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19074
ggagtccaga agccaatccc                                                   20


<210> 19075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19075
ggtattctca gggagtccag                                                   20


<210> 19076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19076
tttggtattc tcagggagtc                                                   20


<210> 19077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19077
tggattttgg tattctcagg                                                   20


<210> 19078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19078
tgtggatttt ggtattctca                                                   20


<210> 19079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19079
ctgtggattt tggtattctc                                                   20


<210> 19080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19080
tctgtggatt ttggtattct                                                   20


<210> 19081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19081
atttgagcat ctgtggattt                                                   20


<210> 19082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19082
ataagagatt tgagcatctg                                                   20


<210> 19083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19083
gccatttgta taagagattt                                                   20


<210> 19084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19084
acactatgcc atttgtataa                                                   20


<210> 19085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19085
aaacactatg ccatttgtat                                                   20


<210> 19086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19086
ggaggatgtg tgtaggttat                                                   20


<210> 19087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19087
ctatatagga ggatgtgtgt                                                   20


<210> 19088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19088
actatatagg aggatgtgtg                                                   20


<210> 19089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19089
gtaattttaa actatatagg                                                   20


<210> 19090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19090
ggtaatttta aactatatag                                                   20


<210> 19091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19091
taggtaattt taaactatat                                                   20


<210> 19092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19092
gtaggtaatt ttaaactata                                                   20


<210> 19093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19093
atacaaatga agtgatgtgt                                                   20


<210> 19094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19094
catacaaatg aagtgatgtg                                                   20


<210> 19095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19095
acattgaatc catacaaatg                                                   20


<210> 19096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19096
acttgaattt tccatatgct                                                   20


<210> 19097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19097
aaaatccaca aagccccaaa                                                   20


<210> 19098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19098
aaaaatccac aaagccccaa                                                   20


<210> 19099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19099
agttggggaa aaaatccaca                                                   20


<210> 19100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19100
ttctggatca gaaatagttg                                                   20


<210> 19101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19101
attctggatc agaaatagtt                                                   20


<210> 19102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19102
aattctggat cagaaatagt                                                   20


<210> 19103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19103
aaccaattct ggatcagaaa                                                   20


<210> 19104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19104
ggattcaacc aattctggat                                                   20


<210> 19105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19105
tctgtggatt caaccaattc                                                   20


<210> 19106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19106
tatccatggt ttctgatctg                                                   20


<210> 19107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19107
cattcagtcc tccatatcca                                                   20


<210> 19108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19108
tatatatata tatatgcatt                                                   20


<210> 19109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19109
gaatactaat ctcatggtgg                                                   20


<210> 19110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19110
taggaatact aatctcatgg                                                   20


<210> 19111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19111
ctataggaat actaatctca                                                   20


<210> 19112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19112
gtctctcttc ttttttctat                                                   20


<210> 19113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19113
ggtctctctt cttttttcta                                                   20


<210> 19114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19114
atggaggagg cagtgagctc                                                   20


<210> 19115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19115
cttcaaatgg aggaggcagt                                                   20


<210> 19116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19116
gtgtcttcaa atggaggagg                                                   20


<210> 19117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19117
actgtgtctt caaatggagg                                                   20


<210> 19118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19118
cactgtgtct tcaaatggag                                                   20


<210> 19119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19119
ctcactgtgt cttcaaatgg                                                   20


<210> 19120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19120
tctcactgtg tcttcaaatg                                                   20


<210> 19121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19121
attctcactg tgtcttcaaa                                                   20


<210> 19122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19122
atttcctggc tggcagaggg                                                   20


<210> 19123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19123
ctcatttcct ggctggcaga                                                   20


<210> 19124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19124
gctcatttcc tggctggcag                                                   20


<210> 19125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19125
ggctcatttc ctggctggca                                                   20


<210> 19126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19126
agggctcatt tcctggctgg                                                   20


<210> 19127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19127
gtgagggctc atttcctggc                                                   20


<210> 19128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19128
cccagtgagg gctcatttcc                                                   20


<210> 19129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19129
ccaatttcgt tccccagtga                                                   20


<210> 19130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19130
gccaatttcg ttccccagtg                                                   20


<210> 19131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19131
agccaatttc gttccccagt                                                   20


<210> 19132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19132
cgccagccaa tttcgttccc                                                   20


<210> 19133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19133
ggagtccaag attaaggcgc                                                   20


<210> 19134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19134
ggctgaggag tccaagatta                                                   20


<210> 19135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19135
aggctgagga gtccaagatt                                                   20


<210> 19136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19136
ttcccgaggc tgaggagtcc                                                   20


<210> 19137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19137
taacagttcc cgaggctgag                                                   20


<210> 19138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19138
tctaacagtt cccgaggctg                                                   20


<210> 19139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19139
ttctaacagt tcccgaggct                                                   20


<210> 19140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19140
tttatttcta acagttcccg                                                   20


<210> 19141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19141
atttatttct aacagttccc                                                   20


<210> 19142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19142
caacagaaat ttatttctaa                                                   20


<210> 19143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19143
agactgggtg gctagaacaa                                                   20


<210> 19144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19144
tataccatag actgggtggc                                                   20


<210> 19145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19145
ataatatacc atagactggg                                                   20


<210> 19146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19146
ataataatat accatagact                                                   20


<210> 19147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19147
cataataata taccatagac                                                   20


<210> 19148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19148
gctgtcataa taatatacca                                                   20


<210> 19149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19149
gtgttggtct tagaaagctg                                                   20


<210> 19150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19150
tgtgttggtc ttagaaagct                                                   20


<210> 19151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19151
ttgtgttggt cttagaaagc                                                   20


<210> 19152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19152
atttttgtgt tggtcttaga                                                   20


<210> 19153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19153
tatcattttt gtgttggtct                                                   20


<210> 19154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19154
gagtattatc atttttgtgt                                                   20


<210> 19155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19155
taaagcaata gcaggagcca                                                   20


<210> 19156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19156
cttaaagcaa tagcaggagc                                                   20


<210> 19157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19157
attacttaaa gcaatagcag                                                   20


<210> 19158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19158
ttattactta aagcaatagc                                                   20


<210> 19159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19159
attattactt aaagcaatag                                                   20


<210> 19160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19160
tagattatta cttaaagcaa                                                   20


<210> 19161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19161
taataataga ttattactta                                                   20


<210> 19162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19162
tcaggagtca gagataataa                                                   20


<210> 19163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19163
gacatgagac tcaggagtca                                                   20


<210> 19164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19164
aagacatgag actcaggagt                                                   20


<210> 19165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19165
gcagaagaca tgagactcag                                                   20


<210> 19166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19166
ttgcagaaga catgagactc                                                   20


<210> 19167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19167
cttgcagaag acatgagact                                                   20


<210> 19168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19168
tacatgcttg cagaagacat                                                   20


<210> 19169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19169
agcatgttac atgcttgcag                                                   20


<210> 19170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19170
tttagcatgt tacatgcttg                                                   20


<210> 19171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19171
tagagtaaca taattcactt                                                   20


<210> 19172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19172
cattatatat ttcactctta                                                   20


<210> 19173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19173
tgcattatat atttcactct                                                   20


<210> 19174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19174
atgtcaatac atttaaggaa                                                   20


<210> 19175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19175
tatgtcaata catttaagga                                                   20


<210> 19176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19176
ctatgtcaat acatttaagg                                                   20


<210> 19177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19177
tttctatgtc aatacattta                                                   20


<210> 19178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19178
gtttctatgt caatacattt                                                   20


<210> 19179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19179
cgtttcattt ggaacataaa                                                   20


<210> 19180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19180
gtcttctaaa acgtttcatt                                                   20


<210> 19181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19181
atgtaggcca agagaatcta                                                   20


<210> 19182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19182
gcctttaaaa tgtaggccaa                                                   20


<210> 19183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19183
atgcctttaa aatgtaggcc                                                   20


<210> 19184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19184
cactcatgcc tttaaaatgt                                                   20


<210> 19185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19185
ccactcatgc ctttaaaatg                                                   20


<210> 19186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19186
tcaaagtcaa agagaatctg                                                   20


<210> 19187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19187
gtaattttct caaagtcaaa                                                   20


<210> 19188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19188
aagtaatttt ctcaaagtca                                                   20


<210> 19189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19189
aatcttaagt aattttctca                                                   20


<210> 19190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19190
caaagaaaat gggcaatctt                                                   20


<210> 19191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19191
acccagaagc caaagaaaat                                                   20


<210> 19192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19192
tacccagaag ccaaagaaaa                                                   20


<210> 19193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19193
aaatttttac ccagaagcca                                                   20


<210> 19194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19194
ccttacaaat ttttacccag                                                   20


<210> 19195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19195
gcaccttaca aatttttacc                                                   20


<210> 19196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19196
agtgcacctt attcttggca                                                   20


<210> 19197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19197
cattcagtgc accttattct                                                   20


<210> 19198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19198
tcctaatcgt gtttaccatt                                                   20


<210> 19199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19199
ttatcaaaaa tttaaaggag                                                   20


<210> 19200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19200
tcttatcaaa aatttaaagg                                                   20


<210> 19201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19201
atcttatcaa aaatttaaag                                                   20


<210> 19202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19202
ttatcttatc aaaaatttaa                                                   20


<210> 19203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19203
gttatcttat caaaaattta                                                   20


<210> 19204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19204
ccgcaaaaga ctgatgtaga                                                   20


<210> 19205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19205
tcgcccgcaa aagactgatg                                                   20


<210> 19206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19206
cacactgatc tcgcccgcaa                                                   20


<210> 19207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19207
gggacactgg tgagacagtt                                                   20


<210> 19208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19208
agagagggac actggtgaga                                                   20


<210> 19209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19209
aaaaagagag ggacactggt                                                   20


<210> 19210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19210
aggtaaaaag agagggacac                                                   20


<210> 19211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19211
actgtggagg taaaaagaga                                                   20


<210> 19212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19212
gactgtggag gtaaaaagag                                                   20


<210> 19213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19213
agactgtgga ggtaaaaaga                                                   20


<210> 19214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19214
acagactgtg gaggtaaaaa                                                   20


<210> 19215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19215
atacagactg tggaggtaaa                                                   20


<210> 19216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19216
atggctcata cagactgtgg                                                   20


<210> 19217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19217
aatggctcat acagactgtg                                                   20


<210> 19218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19218
acaatggctc atacagactg                                                   20


<210> 19219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19219
tcaaaccaca atggctcata                                                   20


<210> 19220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19220
gttattttat caaaccacaa                                                   20


<210> 19221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19221
gatgagcaac gctactagaa                                                   20


<210> 19222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19222
agatgagcaa cgctactaga                                                   20


<210> 19223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19223
atacagatga gcaacgctac                                                   20


<210> 19224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19224
gttaaggtag aaatacagat                                                   20


<210> 19225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19225
accatgttaa ggtagaaata                                                   20


<210> 19226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19226
tccaatgtac catgttaagg                                                   20


<210> 19227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19227
ttttccaatg taccatgtta                                                   20


<210> 19228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19228
gttttccaat gtaccatgtt                                                   20


<210> 19229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19229
tttgtgatca tttgttacaa                                                   20


<210> 19230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19230
atttgtgatc atttgttaca                                                   20


<210> 19231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19231
taatacattt gtattatttt                                                   20


<210> 19232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19232
tcctgcctca caaaaattgt                                                   20


<210> 19233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19233
aaacacagat aactataccc                                                   20


<210> 19234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19234
aaaacacaga taactatacc                                                   20


<210> 19235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19235
atgtgtcttt atacaaaaca                                                   20


<210> 19236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19236
acagaaaaaa taagtggatg                                                   20


<210> 19237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19237
aacagaaaaa ataagtggat                                                   20


<210> 19238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19238
gaacagaaaa aataagtgga                                                   20


<210> 19239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19239
aacagaacag aaaaaataag                                                   20


<210> 19240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19240
tctaacagaa cagaaaaaat                                                   20


<210> 19241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19241
actaattcct tctaacagaa                                                   20


<210> 19242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19242
gatacactaa ttccttctaa                                                   20


<210> 19243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19243
tatcttgctc atataagaaa                                                   20


<210> 19244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19244
atatcttgct catataagaa                                                   20


<210> 19245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19245
gaatgatatc ttgctcatat                                                   20


<210> 19246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19246
ctgctcattt ttatatgaga                                                   20


<210> 19247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19247
agaactgctc atttttatat                                                   20


<210> 19248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19248
cctgttctta ggctactctt                                                   20


<210> 19249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19249
atgtgctttc tcctgttctt                                                   20


<210> 19250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19250
aatgtgcttt ctcctgttct                                                   20


<210> 19251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19251
cccttcatct gaggagcctc                                                   20


<210> 19252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19252
tggctggccc ttcatctgag                                                   20


<210> 19253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19253
tatggctggc ccttcatctg                                                   20


<210> 19254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19254
ttatggctgg cccttcatct                                                   20


<210> 19255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19255
tacattcttt tacttatggc                                                   20


<210> 19256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19256
caaatacatt cttttactta                                                   20


<210> 19257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19257
aaatatgtga gaacataatc                                                   20


<210> 19258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19258
attactattt ctaaatatgt                                                   20


<210> 19259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19259
aattatatcc agtgaatatt                                                   20


<210> 19260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19260
atttatggga aaattatatc                                                   20


<210> 19261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19261
gtgtaaaatt tagaatttat                                                   20


<210> 19262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19262
tgtgtaaaat ttagaattta                                                   20


<210> 19263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19263
ttttagtgat gtgtaaaatt                                                   20


<210> 19264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19264
tcataattca tttttatttt                                                   20


<210> 19265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19265
aatatgtctt caagttagtt                                                   20


<210> 19266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19266
aaaacaatat gtcttcaagt                                                   20


<210> 19267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19267
ctacaaaaca atatgtcttc                                                   20


<210> 19268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19268
taatatttgc tggcatgacc                                                   20


<210> 19269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19269
tcgtaagttg taatatttgc                                                   20


<210> 19270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19270
actgagcaaa agttattcgt                                                   20


<210> 19271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19271
aatctagtag aactgagcaa                                                   20


<210> 19272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19272
tttgcaaatc tagtagaact                                                   20


<210> 19273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19273
taaaaatttt gcaaatctag                                                   20


<210> 19274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19274
tgttaaaaat tttgcaaatc                                                   20


<210> 19275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19275
aagtatacag aaaatgttca                                                   20


<210> 19276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19276
ataagtatac agaaaatgtt                                                   20


<210> 19277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19277
agcaatgcac aataagtata                                                   20


<210> 19278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19278
agataaaagc aatgcacaat                                                   20


<210> 19279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19279
tctttagaaa caaaagataa                                                   20


<210> 19280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19280
aaatatatct ttagaaacaa                                                   20


<210> 19281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19281
aatcttttta aatatatctt                                                   20


<210> 19282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19282
ataactgcat cattgcactt                                                   20


<210> 19283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19283
tgaagagatt tatgagacat                                                   20


<210> 19284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19284
ggtaatttga agagatttat                                                   20


<210> 19285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19285
ctgcgaaaag gtaatttgaa                                                   20


<210> 19286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19286
gtctgcgaaa aggtaatttg                                                   20


<210> 19287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19287
taattgatct gtctgcgaaa                                                   20


<210> 19288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19288
ataattgatc tgtctgcgaa                                                   20


<210> 19289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19289
ttgactccct attactctgc                                                   20


<210> 19290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19290
tagagctcac atgctacact                                                   20


<210> 19291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19291
atagttataa acaagcaata                                                   20


<210> 19292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19292
tgatagttat aaacaagcaa                                                   20


<210> 19293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19293
aataattgat agttataaac                                                   20


<210> 19294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19294
aatgaaacat gaataattga                                                   20


<210> 19295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19295
caatagtatt tgatgcacac                                                   20


<210> 19296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19296
gcaatagtat ttgatgcaca                                                   20


<210> 19297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19297
cagaggggat tttgctgcaa                                                   20


<210> 19298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19298
acatactagc tagagcagag                                                   20


<210> 19299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19299
tacatactag ctagagcaga                                                   20


<210> 19300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19300
ttacatacta gctagagcag                                                   20


<210> 19301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19301
attacatact agctagagca                                                   20


<210> 19302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19302
aaattacata ctagctagag                                                   20


<210> 19303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19303
gagaaattac atactagcta                                                   20


<210> 19304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19304
gggagaaatt acatactagc                                                   20


<210> 19305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19305
gggagggaga aattacatac                                                   20


<210> 19306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19306
gtaatctctc tcaagggagg                                                   20


<210> 19307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19307
tggtaatctc tctcaaggga                                                   20


<210> 19308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19308
atggtaatct ctctcaaggg                                                   20


<210> 19309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19309
catggtaatc tctctcaagg                                                   20


<210> 19310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19310
tacatggtaa tctctctcaa                                                   20


<210> 19311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19311
atacatggta atctctctca                                                   20


<210> 19312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19312
gatacatggt aatctctctc                                                   20


<210> 19313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19313
aaaatgagct gcaggataca                                                   20


<210> 19314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19314
acccaagcaa aatgagctgc                                                   20


<210> 19315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19315
aacccaagca aaatgagctg                                                   20


<210> 19316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19316
tgccataacc caagcaaaat                                                   20


<210> 19317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19317
ataatgctat gccataaccc                                                   20


<210> 19318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19318
agctaaattc tttcacattg                                                   20


<210> 19319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19319
gcaaattttt tacaacaaca                                                   20


<210> 19320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19320
actgtaatcc atttcaacat                                                   20


<210> 19321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19321
gcaatagcca ctctgcaaaa                                                   20


<210> 19322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19322
ttttgtactg atagttgcaa                                                   20


<210> 19323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19323
ccttgggact tttgtactga                                                   20


<210> 19324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19324
aaaggtgtaa aatagtcctt                                                   20


<210> 19325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19325
aaaaggtgta aaatagtcct                                                   20


<210> 19326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19326
agcatgtaaa aggtgtaaaa                                                   20


<210> 19327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19327
ttatcttaat agcatgtaaa                                                   20


<210> 19328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19328
gttatcttaa tagcatgtaa                                                   20


<210> 19329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19329
caacttttat gttatcttaa                                                   20


<210> 19330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19330
ctaaaaataa ttgccatact                                                   20


<210> 19331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19331
tctaaaaata attgccatac                                                   20


<210> 19332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19332
cctgttgatg gtcattaggt                                                   20


<210> 19333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19333
aagtcctgtt gatggtcatt                                                   20


<210> 19334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19334
caagtcctgt tgatggtcat                                                   20


<210> 19335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19335
taagcatcaa gtcctgttga                                                   20


<210> 19336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19336
ctactttagc tataagcatc                                                   20


<210> 19337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19337
caaccctcta ctttagctat                                                   20


<210> 19338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19338
attaatacaa ccctctactt                                                   20


<210> 19339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19339
ggttcttacc atttttagct                                                   20


<210> 19340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19340
gaggtggttc ttaccatttt                                                   20


<210> 19341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19341
ttatttccaa aaagtggagg                                                   20


<210> 19342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19342
agcttatttc caaaaagtgg                                                   20


<210> 19343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19343
tagcttattt ccaaaaagtg                                                   20


<210> 19344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19344
tctagcttat ttccaaaaag                                                   20


<210> 19345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19345
aggtctagct tatttccaaa                                                   20


<210> 19346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19346
tatgcacatt tataaaggtc                                                   20


<210> 19347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19347
ggaaatatgc acatttataa                                                   20


<210> 19348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19348
aggaaatatg cacatttata                                                   20


<210> 19349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19349
tcaaacaaca tattaaaatc                                                   20


<210> 19350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19350
ttcaaacaac atattaaaat                                                   20


<210> 19351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19351
ttcaaaattt agctactttt                                                   20


<210> 19352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19352
acaccaaata tttcaaaatt                                                   20


<210> 19353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19353
gtagtaaata tttagtgatg                                                   20


<210> 19354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19354
attggtaggt agtaaatatt                                                   20


<210> 19355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19355
tttatgcacc cattggtagg                                                   20


<210> 19356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19356
agttttatgc acccattggt                                                   20


<210> 19357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19357
gagttttatg cacccattgg                                                   20


<210> 19358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19358
aaagagtttt atgcacccat                                                   20


<210> 19359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19359
tataactata gtgcccaaaa                                                   20


<210> 19360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19360
agtataacta tagtgcccaa                                                   20


<210> 19361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19361
tatatgggta agtataacta                                                   20


<210> 19362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19362
tttctctatt ttatatgggt                                                   20


<210> 19363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19363
atattttctc tattttatat                                                   20


<210> 19364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19364
aatattttct ctattttata                                                   20


<210> 19365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19365
aggctacctc tgtatcatac                                                   20


<210> 19366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19366
caggctacct ctgtatcata                                                   20


<210> 19367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19367
tactaaaaat gtaagaaccc                                                   20


<210> 19368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19368
ctactaaaaa tgtaagaacc                                                   20


<210> 19369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19369
taatttgcta ctaaaaatgt                                                   20


<210> 19370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19370
agtagtaaga gtagttagta                                                   20


<210> 19371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19371
atattagtag taagagtagt                                                   20


<210> 19372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19372
atttatatta gtagtaagag                                                   20


<210> 19373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19373
aaaatttata ttagtagtaa                                                   20


<210> 19374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19374
tgaaaattta tattagtagt                                                   20


<210> 19375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19375
acattgaaaa tttatattag                                                   20


<210> 19376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19376
aacacattga aaatttatat                                                   20


<210> 19377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19377
agaatgagac aagcttcatg                                                   20


<210> 19378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19378
ttgtaatgat agaatgagac                                                   20


<210> 19379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19379
tgtggttgta atgatagaat                                                   20


<210> 19380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19380
tcattatgtg gttgtaatga                                                   20


<210> 19381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19381
aagagtacta cttcattatg                                                   20


<210> 19382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19382
tatctataaa atgaggagaa                                                   20


<210> 19383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19383
cttatctata aaatgaggag                                                   20


<210> 19384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19384
tttcttatct ataaaatgag                                                   20


<210> 19385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19385
actttcttat ctataaaatg                                                   20


<210> 19386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19386
aactttctta tctataaaat                                                   20


<210> 19387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19387
atacattctt taacctatat                                                   20


<210> 19388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19388
aatacattct ttaacctata                                                   20


<210> 19389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19389
cagttaagcc atgaccctat                                                   20


<210> 19390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19390
actatatttg tatcccagtt                                                   20


<210> 19391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19391
ctagaactat atttgtatcc                                                   20


<210> 19392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19392
aagagcatgg gttctaagac                                                   20


<210> 19393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19393
tggctaagag catgggttct                                                   20


<210> 19394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19394
tacataatgg ctaagagcat                                                   20


<210> 19395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19395
atacataatg gctaagagca                                                   20


<210> 19396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19396
atagcataca taatggctaa                                                   20


<210> 19397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19397
atatagcata cataatggct                                                   20


<210> 19398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19398
aggtgatata gcatacataa                                                   20


<210> 19399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19399
ccagctctta agaggtgata                                                   20


<210> 19400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19400
aagctgtacc agctcttaag                                                   20


<210> 19401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19401
aaagctgtac cagctcttaa                                                   20


<210> 19402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19402
ggaaagctgt accagctctt                                                   20


<210> 19403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19403
tacagatggg aaagctgtac                                                   20


<210> 19404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19404
ttctcatttt acagatggga                                                   20


<210> 19405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19405
ctttttctca ttttacagat                                                   20


<210> 19406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19406
tctttttctc attttacaga                                                   20


<210> 19407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19407
ttactctttt tctcatttta                                                   20


<210> 19408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19408
tctaccctta caaccacatg                                                   20


<210> 19409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19409
attctaccct tacaaccaca                                                   20


<210> 19410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19410
attgttctaa tttctttgtg                                                   20


<210> 19411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19411
ttacattttt agtagcaaat                                                   20


<210> 19412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19412
ctggattctt acatttttag                                                   20


<210> 19413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19413
agcctggatt cttacatttt                                                   20


<210> 19414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19414
tgtatgacac agaagtagcc                                                   20


<210> 19415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19415
gttcctgtat gacacagaag                                                   20


<210> 19416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19416
attgttcctg tatgacacag                                                   20


<210> 19417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19417
tgcattgttc ctgtatgaca                                                   20


<210> 19418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19418
gctaagagct ttggttcatg                                                   20


<210> 19419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19419
tggctaagag ctttggttca                                                   20


<210> 19420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19420
tacataatgg ctaagagctt                                                   20


<210> 19421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19421
gtagcataca taatggctaa                                                   20


<210> 19422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19422
gtgtagcata cataatggct                                                   20


<210> 19423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19423
aggtggtgta gcatacataa                                                   20


<210> 19424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19424
aatagcatta agaggtggtg                                                   20


<210> 19425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19425
tgtgtaatag cattaagagg                                                   20


<210> 19426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19426
ttttgtgtaa tagcattaag                                                   20


<210> 19427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19427
tttttgtgta atagcattaa                                                   20


<210> 19428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19428
catttttgtg taatagcatt                                                   20


<210> 19429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19429
atgtctacat ttttgtgtaa                                                   20


<210> 19430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19430
tatgcaaaca tctagccaca                                                   20


<210> 19431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19431
agcaaaaata tgcaaacatc                                                   20


<210> 19432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19432
agggagaaaa ttgagacagg                                                   20


<210> 19433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19433
caaagggaga aaattgagac                                                   20


<210> 19434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19434
gcaaagggag aaaattgaga                                                   20


<210> 19435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19435
ttgtgcaaag ggagaaaatt                                                   20


<210> 19436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19436
catcaaggtt tgtgcaaagg                                                   20


<210> 19437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19437
cacatcaagg tttgtgcaaa                                                   20


<210> 19438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19438
ccacatcaag gtttgtgcaa                                                   20


<210> 19439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19439
tccacatcaa ggtttgtgca                                                   20


<210> 19440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19440
atttcttgaa atccacatca                                                   20


<210> 19441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19441
aatttcttga aatccacatc                                                   20


<210> 19442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19442
acaaagaatc tagagttcca                                                   20


<210> 19443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19443
agacaaggac aaagaatcta                                                   20


<210> 19444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19444
aaagacaagg acaaagaatc                                                   20


<210> 19445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19445
gggaaacaaa gacaaggaca                                                   20


<210> 19446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19446
gttcccggga aacaaagaca                                                   20


<210> 19447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19447
tgttcccggg aaacaaagac                                                   20


<210> 19448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19448
agaagtgttc ccgggaaaca                                                   20


<210> 19449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19449
cctccataag aagtgttccc                                                   20


<210> 19450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 19450
tcctccataa gaagtgttcc                                                   20


<210> 19451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19451
cttcaaatgt cctccataag                                                   20


<210> 19452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19452
cagcttcaaa tgtcctccat                                                   20


<210> 19453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19453
tttccttttc attgaaagga                                                   20


<210> 19454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19454
gctttttcct tttcattgaa                                                   20


<210> 19455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19455
agctttttcc ttttcattga                                                   20


<210> 19456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19456
aaataagttg caacaactga                                                   20


<210> 19457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19457
aagtcagtgg atatctaaat                                                   20


<210> 19458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19458
ccataggtgg gtaaagtcag                                                   20


<210> 19459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19459
taaccatagg tgggtaaagt                                                   20


<210> 19460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19460
agaataacca taggtgggta                                                   20


<210> 19461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19461
cagttagaat aaccataggt                                                   20


<210> 19462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19462
tcagttagaa taaccatagg                                                   20


<210> 19463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19463
gtttcagtta gaataaccat                                                   20


<210> 19464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19464
tgtttcagtt agaataacca                                                   20


<210> 19465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19465
cacgtatttt ctgtttcagt                                                   20


<210> 19466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19466
tttacacgta ttttctgttt                                                   20


<210> 19467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19467
gtaatataat ctaagaataa                                                   20


<210> 19468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19468
gacacattgt aatataatct                                                   20


<210> 19469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19469
gttatattgt agttatactt                                                   20


<210> 19470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19470
attatattgt agttatattg                                                   20


<210> 19471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19471
gtttgccata aattatattg                                                   20


<210> 19472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19472
tatgaatgct caaaatgttt                                                   20


<210> 19473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19473
aggattcttt acaaatttca                                                   20


<210> 19474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19474
tatcataaag ctgtttacat                                                   20


<210> 19475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19475
atatcataaa gctgtttaca                                                   20


<210> 19476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19476
aaatagccat gaatatcata                                                   20


<210> 19477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19477
gcttcatgaa aataaataaa                                                   20


<210> 19478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19478
tcttcttgag gaaaacaatc                                                   20


<210> 19479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19479
attatgttat tatcttcttg                                                   20


<210> 19480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19480
tattatgtta ttatcttctt                                                   20


<210> 19481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19481
caatttttta aaaatatctg                                                   20


<210> 19482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19482
ggtttaggac ctatgtatga                                                   20


<210> 19483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19483
gggtttagga cctatgtatg                                                   20


<210> 19484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19484
cagggaattg gcctgggttt                                                   20


<210> 19485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19485
ccagggaatt ggcctgggtt                                                   20


<210> 19486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19486
gatggccagg gaattggcct                                                   20


<210> 19487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19487
ggatggccag ggaattggcc                                                   20


<210> 19488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19488
aattaggatg gccagggaat                                                   20


<210> 19489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19489
caactaaatt aggatggcca                                                   20


<210> 19490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19490
ccaactaaat taggatggcc                                                   20


<210> 19491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19491
gccaactaaa ttaggatggc                                                   20


<210> 19492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19492
aagggccaac taaattagga                                                   20


<210> 19493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19493
aaagaagggc caactaaatt                                                   20


<210> 19494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19494
gaaagaaggg ccaactaaat                                                   20


<210> 19495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19495
taatagaagt gctgaaagaa                                                   20


<210> 19496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19496
ttaatagaag tgctgaaaga                                                   20


<210> 19497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19497
gttaatagaa gtgctgaaag                                                   20


<210> 19498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19498
aatgttaata gaagtgctga                                                   20


<210> 19499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19499
tttcagagaa atgttaatag                                                   20


<210> 19500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19500
ctatttcaga gaaatgttaa                                                   20


<210> 19501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19501
agttctaaat agctatttca                                                   20


<210> 19502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19502
gcagttctaa atagctattt                                                   20


<210> 19503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19503
gtaaataaag cagttctaaa                                                   20


<210> 19504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19504
aaatgcatat gtaaataaag                                                   20


<210> 19505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19505
ataaaatgca tatgtaaata                                                   20


<210> 19506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19506
tttgatagct ttattaaaaa                                                   20


<210> 19507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19507
gttttgatag ctttattaaa                                                   20


<210> 19508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19508
atgattttat agagttttga                                                   20


<210> 19509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19509
atacttagca tgattttata                                                   20


<210> 19510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19510
aaatacttag catgatttta                                                   20


<210> 19511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19511
acatcacaac ccaaaatact                                                   20


<210> 19512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19512
aaaagatttg ggtgacttgt                                                   20


<210> 19513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19513
acctagtttg caaaagattt                                                   20


<210> 19514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19514
tacctagttt gcaaaagatt                                                   20


<210> 19515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19515
gatagttacc tagtttgcaa                                                   20


<210> 19516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19516
ttagcttttt gatagttacc                                                   20


<210> 19517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19517
acctaatttt agctttttga                                                   20


<210> 19518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19518
aaaattagag aacctaattt                                                   20


<210> 19519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19519
aatctttcgg atgaaaatta                                                   20


<210> 19520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19520
caaatctttc ggatgaaaat                                                   20


<210> 19521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 19521
aggtttgaac acaaatcttt                                                   20


<210> 19522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19522
tgagccacca tgccccaaac                                                   20


<210> 19523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19523
atgagccacc atgccccaaa                                                   20


<210> 19524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19524
catgctgggg ttacaggcat                                                   20


<210> 19525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19525
tgccaacatg ctggggttac                                                   20


<210> 19526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19526
ctgccaacat gctggggtta                                                   20


<210> 19527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19527
catgacctgc caacatgctg                                                   20


<210> 19528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19528
tcatgacctg ccaacatgct                                                   20


<210> 19529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19529
gtcatgacct gccaacatgc                                                   20


<210> 19530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19530
agtctcaaac tcctggcttc                                                   20


<210> 19531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19531
ccaggctagt ctcaaactcc                                                   20


<210> 19532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19532
tcttgctatg ttgcccaggc                                                   20


<210> 19533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19533
ggggtcttgc tatgttgccc                                                   20


<210> 19534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19534
aggggtcttg ctatgttgcc                                                   20


<210> 19535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19535
tttaaatttt tgtagataag                                                   20


<210> 19536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19536
atttaaattt ttgtagataa                                                   20


<210> 19537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19537
tatttaaatt tttgtagata                                                   20


<210> 19538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19538
atatttaaat ttttgtagat                                                   20


<210> 19539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19539
ggctaatatt taaatttttg                                                   20


<210> 19540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19540
caggtacatg ccaccatgcc                                                   20


<210> 19541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19541
tcccaagtag ctaagactac                                                   20


<210> 19542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19542
ctcccaagta gctaagacta                                                   20


<210> 19543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19543
cctcagcctc ccaagtagct                                                   20


<210> 19544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19544
tcctgcctca gcctcccaag                                                   20


<210> 19545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19545
ccctcctgcc tcagcctccc                                                   20


<210> 19546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19546
ctcaagcaac cctcctgcct                                                   20


<210> 19547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19547
gcagcctcaa ctctgggctc                                                   20


<210> 19548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19548
ctctctgcag cctcaactct                                                   20


<210> 19549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19549
gctctctgca gcctcaactc                                                   20


<210> 19550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19550
ggcatgatca tagctctctg                                                   20


<210> 19551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19551
agagtgcaat ggcatgatca                                                   20


<210> 19552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19552
tcacccaggc tagagtgcaa                                                   20


<210> 19553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19553
tcgctctgtc acccaggcta                                                   20


<210> 19554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19554
tctcgctctg tcacccaggc                                                   20


<210> 19555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19555
caggtctcgc tctgtcaccc                                                   20


<210> 19556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19556
ccaggtctcg ctctgtcacc                                                   20


<210> 19557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19557
aaaaactttt ttaagtgacc                                                   20


<210> 19558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19558
taaaaacttt tttaagtgac                                                   20


<210> 19559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19559
ggttttctaa aaactttttt                                                   20


<210> 19560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19560
agaataaaat ggaagcaaac                                                   20


<210> 19561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19561
tagaataaaa tggaagcaaa                                                   20


<210> 19562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19562
cttaacttag aataaaatgg                                                   20


<210> 19563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19563
gaacttaact tagaataaaa                                                   20


<210> 19564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19564
ttacactgaa gaacttaact                                                   20


<210> 19565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19565
acagaaaggc agttacactg                                                   20


<210> 19566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19566
cacccaacaa tacagaaagg                                                   20


<210> 19567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19567
ttacacccaa caatacagaa                                                   20


<210> 19568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19568
attacaccca acaatacaga                                                   20


<210> 19569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19569
acttattaca cccaacaata                                                   20


<210> 19570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19570
tgatggtttc acccttcaga                                                   20


<210> 19571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19571
ctgatggttt cacccttcag                                                   20


<210> 19572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19572
gtactgatgg tttcaccctt                                                   20


<210> 19573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19573
tagattactg tttgtactga                                                   20


<210> 19574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19574
attagacctc tctttccatg                                                   20


<210> 19575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19575
gtataagctt gaagtaaaat                                                   20


<210> 19576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19576
gcttattaag tataagcttg                                                   20


<210> 19577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19577
agaaagagct tattaagtat                                                   20


<210> 19578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19578
tttggaagaa agagcttatt                                                   20


<210> 19579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19579
aaaataatat ttggaagaaa                                                   20


<210> 19580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19580
taaaaataat atttggaaga                                                   20


<210> 19581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19581
caattaaaaa taatatttgg                                                   20


<210> 19582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19582
tatcaattaa aaataatatt                                                   20


<210> 19583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19583
tatatattta cgtttgtttc                                                   20


<210> 19584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19584
atatatattt acgtttgttt                                                   20


<210> 19585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19585
ttttttaaaa taacatggtt                                                   20


<210> 19586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19586
tgtttttttt taaaataaca                                                   20


<210> 19587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19587
gcatttcaaa aatatatata                                                   20


<210> 19588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19588
ttaacaacac aatttcttct                                                   20


<210> 19589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19589
aaataaaaaa tatgggcaac                                                   20


<210> 19590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19590
ttatgtaaaa taaaaaatat                                                   20


<210> 19591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19591
tttatgtaaa ataaaaaata                                                   20


<210> 19592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19592
agtaagacaa gatgtttgac                                                   20


<210> 19593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19593
tagtaagaca agatgtttga                                                   20


<210> 19594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19594
cttacataat gtagtaagac                                                   20


<210> 19595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19595
gaatacttac ataatgtagt                                                   20


<210> 19596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19596
ttatgaatac ttacataatg                                                   20


<210> 19597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19597
atttttaaat acattcaatt                                                   20


<210> 19598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19598
acaaaatata ttacatttat                                                   20


<210> 19599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19599
aggttttgat aatttaagta                                                   20


<210> 19600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19600
taggttttga taatttaagt                                                   20


<210> 19601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19601
ataggttttg ataatttaag                                                   20


<210> 19602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19602
gaaataggtt ttgataattt                                                   20


<210> 19603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19603
ctaccaagcc tgttggaaat                                                   20


<210> 19604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19604
cctaccaagc ctgttggaaa                                                   20


<210> 19605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19605
cacataccta ccaagcctgt                                                   20


<210> 19606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19606
cattttatca catacctacc                                                   20


<210> 19607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19607
cagtgttttc cgagactaca                                                   20


<210> 19608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19608
gacaccatgc agtgttttcc                                                   20


<210> 19609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19609
ttaatatgaa agacaccatg                                                   20


<210> 19610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19610
cactttttaa tttaatatga                                                   20


<210> 19611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19611
atcttaggtt cattcatctt                                                   20


<210> 19612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19612
catcttaggt tcattcatct                                                   20


<210> 19613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19613
aagattcttt ataccatctt                                                   20


<210> 19614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19614
aaagattctt tataccatct                                                   20


<210> 19615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19615
taaaactcaa tctagggcta                                                   20


<210> 19616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19616
tacgtataaa actcaatcta                                                   20


<210> 19617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19617
ctacgtataa aactcaatct                                                   20


<210> 19618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19618
tctacgtata aaactcaatc                                                   20


<210> 19619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19619
acaacatccg ttattacttt                                                   20


<210> 19620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19620
aaagaatgag atcagaagtc                                                   20


<210> 19621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19621
tggttaaaga atgagatcag                                                   20


<210> 19622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19622
ttatggttaa agaatgagat                                                   20


<210> 19623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19623
aagatttatg gttaaagaat                                                   20


<210> 19624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19624
gaaacaaaga tttatggtta                                                   20


<210> 19625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19625
cctatagaaa caaagattta                                                   20


<210> 19626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19626
taaacgtacc tatagaaaca                                                   20


<210> 19627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19627
agaggattta aacgtaccta                                                   20


<210> 19628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19628
ctggcaattt aaaaagaaag                                                   20


<210> 19629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19629
tctggcaatt taaaaagaaa                                                   20


<210> 19630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19630
gttctggcaa tttaaaaaga                                                   20


<210> 19631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19631
tgttgttctg gcaatttaaa                                                   20


<210> 19632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19632
gcacatattt tttgttgttc                                                   20


<210> 19633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19633
atttatataa taaatgttta                                                   20


<210> 19634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19634
gatttttgtg ggaggttttg                                                   20


<210> 19635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19635
acttagaaga tttttgtggg                                                   20


<210> 19636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19636
tacttagaag atttttgtgg                                                   20


<210> 19637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19637
tttacttaga agatttttgt                                                   20


<210> 19638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19638
ttttacttag aagatttttg                                                   20


<210> 19639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19639
tagaatgtag ttttacttag                                                   20


<210> 19640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19640
aggtagaatg tagttttact                                                   20


<210> 19641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19641
tgagctacac aggtagaatg                                                   20


<210> 19642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19642
caaaaattga gctacacagg                                                   20


<210> 19643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19643
aggcaaaaat tgagctacac                                                   20


<210> 19644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19644
caggcaaaaa ttgagctaca                                                   20


<210> 19645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19645
ttcatgcaca ggcaaaaatt                                                   20


<210> 19646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19646
ctataaagtt attcatgcac                                                   20


<210> 19647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19647
tctataaagt tattcatgca                                                   20


<210> 19648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19648
tatgagatct ttcttctata                                                   20


<210> 19649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19649
tgagtttatt tcaggaatat                                                   20


<210> 19650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19650
ttttttcgtg agtttatttc                                                   20


<210> 19651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19651
tttttttcgt gagtttattt                                                   20


<210> 19652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19652
accataatgc tttttttcgt                                                   20


<210> 19653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19653
cctattaata gtaatttgaa                                                   20


<210> 19654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19654
tttttgaaaa cacctattaa                                                   20


<210> 19655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19655
ttgcattagc tgtagacatc                                                   20


<210> 19656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19656
tattcatttt gcattagctg                                                   20


<210> 19657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19657
agcacatatt cattttgcat                                                   20


<210> 19658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19658
ccatgggctt ctaatttatc                                                   20


<210> 19659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19659
ctcaatcaac acagtaccat                                                   20


<210> 19660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19660
cctcaatcaa cacagtacca                                                   20


<210> 19661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19661
atattttgcc tcaatcaaca                                                   20


<210> 19662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19662
cttcaatgta tacaatgagg                                                   20


<210> 19663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19663
atacttcaat gtatacaatg                                                   20


<210> 19664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19664
tatacttcaa tgtatacaat                                                   20


<210> 19665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19665
attatggaag taatcttttt                                                   20


<210> 19666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19666
cttactttcc taaattatgg                                                   20


<210> 19667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19667
caacttactt tcctaaatta                                                   20


<210> 19668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19668
aataaaaaag cattgaaata                                                   20


<210> 19669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19669
gaataaaaaa gcattgaaat                                                   20


<210> 19670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19670
tgaataaaaa agcattgaaa                                                   20


<210> 19671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19671
tgtgtttagt atgaataaaa                                                   20


<210> 19672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19672
actttacaca gatatgtgtt                                                   20


<210> 19673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19673
gtaatatgac agactttaca                                                   20


<210> 19674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19674
tttcaaatca tgtaatatga                                                   20


<210> 19675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19675
tatacaatcc cgtgtttggc                                                   20


<210> 19676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19676
cttgtataca atcccgtgtt                                                   20


<210> 19677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19677
agcagataat aacttgggca                                                   20


<210> 19678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19678
acttgagcag ataataactt                                                   20


<210> 19679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19679
tacttgagca gataataact                                                   20


<210> 19680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19680
gaccacggta catacttgag                                                   20


<210> 19681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19681
tttgaccacg gtacatactt                                                   20


<210> 19682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 19682
tgcagttagt tgtttgacca                                                   20


<210> 19683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19683
aatccttcct gatatgcagt                                                   20


<210> 19684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19684
atgaaatcct tcctgatatg                                                   20


<210> 19685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19685
tcatcctttc gctgtaagca                                                   20


<210> 19686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19686
tttagtcatc ctttcgctgt                                                   20


<210> 19687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19687
ctttcttatg cagtattgtt                                                   20


<210> 19688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19688
aattttcctg ctttcttatg                                                   20


<210> 19689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19689
gctgcccaaa atactgataa                                                   20


<210> 19690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19690
tctatttgct attatttaca                                                   20


<210> 19691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19691
gagaaaaaag ttattgacag                                                   20


<210> 19692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19692
actgagaaaa aagttattga                                                   20


<210> 19693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19693
aacaaagata actgagaaaa                                                   20


<210> 19694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19694
caaaaaaaac aaagataact                                                   20


<210> 19695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19695
tacactcctc aaaaaaaaca                                                   20


<210> 19696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19696
agaacttgaa aaattattct                                                   20


<210> 19697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19697
ttttgttcat agaataacca                                                   20


<210> 19698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19698
ttcatatccc tttttgttca                                                   20


<210> 19699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19699
ctttagagta ttgtgtttca                                                   20


<210> 19700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19700
aaggataaga cttaccttta                                                   20


<210> 19701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19701
acaaggataa gacttacctt                                                   20


<210> 19702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19702
actcacatgc caacaaggat                                                   20


<210> 19703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19703
tcttgactca catgccaaca                                                   20


<210> 19704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19704
atcttgactc acatgccaac                                                   20


<210> 19705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19705
atgggattaa aaatatatgt                                                   20


<210> 19706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19706
catgggatta aaaatatatg                                                   20


<210> 19707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19707
atgtgcctat aaaatgccat                                                   20


<210> 19708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19708
tatgtgccta taaaatgcca                                                   20


<210> 19709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19709
aaatttattc tacattgcat                                                   20


<210> 19710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19710
agaggttatt ctatattttg                                                   20


<210> 19711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19711
cagaggttat tctatatttt                                                   20


<210> 19712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19712
gactttttat caatgtacag                                                   20


<210> 19713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19713
tgacttttta tcaatgtaca                                                   20


<210> 19714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19714
cttgactttt tatcaatgta                                                   20


<210> 19715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19715
agttaaaatg cattattagg                                                   20


<210> 19716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19716
ttagttaaaa tgcattatta                                                   20


<210> 19717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19717
tttagttaaa atgcattatt                                                   20


<210> 19718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19718
gtttagttaa aatgcattat                                                   20


<210> 19719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19719
ggacattagt tatgaatgtt                                                   20


<210> 19720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19720
ttgatagaag taatggacat                                                   20


<210> 19721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19721
gaaatgcttg atagaagtaa                                                   20


<210> 19722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19722
tgcaatgaaa tgcttgatag                                                   20


<210> 19723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19723
ctttgcaatg aaatgcttga                                                   20


<210> 19724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19724
atcaacaaaa gtatttgcct                                                   20


<210> 19725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19725
tattatttgg aaatcaacaa                                                   20


<210> 19726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19726
tctattattt atctattatt                                                   20


<210> 19727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19727
aaataaacaa cacacgcata                                                   20


<210> 19728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19728
tcttttcaca ggattgtaat                                                   20


<210> 19729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19729
ctgccttgtc atcttttcac                                                   20


<210> 19730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19730
tctgccttgt catcttttca                                                   20


<210> 19731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19731
taataaatca gaagaccatg                                                   20


<210> 19732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19732
tttggttttt aataaatcag                                                   20


<210> 19733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19733
ttttttggtt tttaataaat                                                   20


<210> 19734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19734
acaaaagtga ttcagttttt                                                   20


<210> 19735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19735
tatagcatac aaaagtgatt                                                   20


<210> 19736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19736
ttattgatta tagcatacaa                                                   20


<210> 19737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19737
tctgtaggaa ttattgatta                                                   20


<210> 19738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19738
gaatcgtaag agaactctgt                                                   20


<210> 19739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19739
agaatcgtaa gagaactctg                                                   20


<210> 19740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19740
tgattcttta agaatcgtaa                                                   20


<210> 19741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19741
gatgattctt taagaatcgt                                                   20


<210> 19742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19742
ttttgcactg atgattcttt                                                   20


<210> 19743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19743
aggtgggcag cattagcaga                                                   20


<210> 19744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19744
agaaaggtgg gcagcattag                                                   20


<210> 19745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19745
ctaagaaagg tgggcagcat                                                   20


<210> 19746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19746
gatttcctaa gaaaggtggg                                                   20


<210> 19747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19747
tctgatttcc taagaaaggt                                                   20


<210> 19748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19748
ctctgatttc ctaagaaagg                                                   20


<210> 19749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19749
taactctgat ttcctaagaa                                                   20


<210> 19750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19750
ctaactctga tttcctaaga                                                   20


<210> 19751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19751
gtcactaact ctgatttcct                                                   20


<210> 19752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19752
aaatattctc gaaggcagtg                                                   20


<210> 19753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19753
tatcaaaata ttctcgaagg                                                   20


<210> 19754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19754
ttttatcaaa atattctcga                                                   20


<210> 19755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19755
tttttatcaa aatattctcg                                                   20


<210> 19756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19756
ttaataaaac tcttttgagg                                                   20


<210> 19757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19757
gtgttaataa aactcttttg                                                   20


<210> 19758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19758
tgtgttaata aaactctttt                                                   20


<210> 19759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19759
atattgttta cagcctgtga                                                   20


<210> 19760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19760
catttttgat atattgttta                                                   20


<210> 19761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19761
agcaaggaaa gcaaaaaata                                                   20


<210> 19762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19762
acagcaagga aagcaaaaaa                                                   20


<210> 19763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19763
aaagggaaag acagcaagga                                                   20


<210> 19764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19764
agacaaaggg aaagacagca                                                   20


<210> 19765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19765
aagacaaagg gaaagacagc                                                   20


<210> 19766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19766
aaggaagaca aagggaaaga                                                   20


<210> 19767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19767
agaaaaggaa gacaaaggga                                                   20


<210> 19768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19768
gaacagaaaa ggaagacaaa                                                   20


<210> 19769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19769
agaacagaaa aggaagacaa                                                   20


<210> 19770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19770
cagaacagaa aaggaagaca                                                   20


<210> 19771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19771
acaagacaga acagaaaagg                                                   20


<210> 19772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19772
tgaacaagac agaacagaaa                                                   20


<210> 19773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19773
atgaacaaga cagaacagaa                                                   20


<210> 19774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19774
gaaatatgaa caagacagaa                                                   20


<210> 19775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19775
aaagagaaat atgaacaaga                                                   20


<210> 19776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19776
agacaaagag aaatatgaac                                                   20


<210> 19777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19777
gtgtaacaaa gccagacaaa                                                   20


<210> 19778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19778
tagtgtaaca aagccagaca                                                   20


<210> 19779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19779
atatgatagt gtaacaaagc                                                   20


<210> 19780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19780
cttcatatga tagtgtaaca                                                   20


<210> 19781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19781
acctctccac cttcatatga                                                   20


<210> 19782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19782
gaactcaagt ccagaaaaaa                                                   20


<210> 19783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19783
tgttaatgag aactcaagtc                                                   20


<210> 19784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19784
gataatgtta atgagaactc                                                   20


<210> 19785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19785
tggcttttga taatgttaat                                                   20


<210> 19786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19786
tttactcaat aaaaaagata                                                   20


<210> 19787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19787
tgatgattta ctcaataaaa                                                   20


<210> 19788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19788
atacataaaa gatggagaca                                                   20


<210> 19789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19789
atatacataa aagatggaga                                                   20


<210> 19790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19790
aagtatatac ataaaagatg                                                   20


<210> 19791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19791
tcaagtatat acataaaaga                                                   20


<210> 19792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19792
tatatcaagt atatacataa                                                   20


<210> 19793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19793
caaaatgtca aaaatatatc                                                   20


<210> 19794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19794
cttatagacg ttaccgctta                                                   20


<210> 19795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19795
gcttatagac gttaccgctt                                                   20


<210> 19796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19796
actgtcattc agcgtgctta                                                   20


<210> 19797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19797
atgtgtctgc tactgtcatt                                                   20


<210> 19798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19798
cacactaaaa cggaaacaag                                                   20


<210> 19799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19799
ccacactaaa acggaaacaa                                                   20


<210> 19800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19800
aaccacacta aaacggaaac                                                   20


<210> 19801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 19801
ccatcacaac cacactaaaa                                                   20


<210> 19802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19802
catgtctgca aatccttcca                                                   20


<210> 19803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19803
ttcgttcaca gatggaagaa                                                   20


<210> 19804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19804
cttcgttcac agatggaaga                                                   20


<210> 19805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19805
ttctcttcgt tcacagatgg                                                   20


<210> 19806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19806
ggattctctt cgttcacaga                                                   20


<210> 19807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19807
agatggattc tcttcgttca                                                   20


<210> 19808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19808
tttgggtgag agtggggaga                                                   20


<210> 19809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19809
gtgttttggg tgagagtggg                                                   20


<210> 19810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19810
gcgtgttttg ggtgagagtg                                                   20


<210> 19811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19811
agcgtgtttt gggtgagagt                                                   20


<210> 19812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19812
aagcgtgttt tgggtgagag                                                   20


<210> 19813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19813
acaaagcgtg ttttgggtga                                                   20


<210> 19814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19814
ttacaaagcg tgttttgggt                                                   20


<210> 19815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19815
gcttttacaa agcgtgtttt                                                   20


<210> 19816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19816
tgcttttaca aagcgtgttt                                                   20


<210> 19817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19817
acatcttatt tgcttttaca                                                   20


<210> 19818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 19818
tgcccatggt tagtggtgac                                                   20


<210> 19819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19819
atggatctgc ccatggttag                                                   20


<210> 19820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19820
gccatggatc tgcccatggt                                                   20


<210> 19821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19821
cattgccatg gatctgccca                                                   20


<210> 19822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19822
caaagtccag ctcattgcca                                                   20


<210> 19823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19823
tagcaaaacc caacaaagtc                                                   20


<210> 19824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19824
tctcatagca aaacccaaca                                                   20


<210> 19825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19825
cctggatcct cctcttctca                                                   20


<210> 19826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19826
ctctgatttt gcagctgccc                                                   20


<210> 19827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19827
ctctaaactc tctgattttg                                                   20


<210> 19828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19828
ccgatgcgac ccagtttata                                                   20


<210> 19829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19829
tcccgatgcg acccagttta                                                   20


<210> 19830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19830
agtttgatcc cgatgcgacc                                                   20


<210> 19831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19831
tgttctatga ggtttgggag                                                   20


<210> 19832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19832
agatgttcta tgaggtttgg                                                   20


<210> 19833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19833
tgagatgttc tatgaggttt                                                   20


<210> 19834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19834
ttgagatgtt ctatgaggtt                                                   20


<210> 19835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19835
tgactttgag atgttctatg                                                   20


<210> 19836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19836
atgactttga gatgttctat                                                   20


<210> 19837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19837
ctctgagtga ggatgacttt                                                   20


<210> 19838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19838
aagtactgaa cctctgagtg                                                   20


<210> 19839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19839
aaagtactga acctctgagt                                                   20


<210> 19840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19840
gaagaaagta ctgaacctct                                                   20


<210> 19841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19841
tttagtgttg ccactgaaga                                                   20


<210> 19842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19842
gaattttagt gttgccactg                                                   20


<210> 19843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19843
gcagtcatac tggagaattt                                                   20


<210> 19844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19844
tgtacattgc agtcatactg                                                   20


<210> 19845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19845
catgtacatt gcagtcatac                                                   20


<210> 19846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19846
tgtggtgaac atgtacattg                                                   20


<210> 19847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19847
catcatatcc ttcctggttg                                                   20


<210> 19848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19848
ttatatcatc atatccttcc                                                   20


<210> 19849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19849
gttggaatat tctactttgt                                                   20


<210> 19850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19850
gactgtggta acccatctgt                                                   20


<210> 19851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19851
agttcagttg aaggagactg                                                   20


<210> 19852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19852
tcctggaagt tcagttgaag                                                   20


<210> 19853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19853
catcctggaa gttcagttga                                                   20


<210> 19854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19854
tcatcctgga agttcagttg                                                   20


<210> 19855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19855
aaaagttcat cctggaagtt                                                   20


<210> 19856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19856
ccaaaaaaag ttcatcctgg                                                   20


<210> 19857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19857
gacccaaaaa aagttcatcc                                                   20


<210> 19858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19858
acccgactgt gacccaaaaa                                                   20


<210> 19859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19859
tagcacctat tcttaacagt                                                   20


<210> 19860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19860
ttgctagcac ctattcttaa                                                   20


<210> 19861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19861
tgctggctgg gatggattgc                                                   20


<210> 19862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19862
acaacctctg ctggctggga                                                   20


<210> 19863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19863
aattacaacc tctgctggct                                                   20


<210> 19864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19864
aaattacaac ctctgctggc                                                   20


<210> 19865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19865
ttccaaatta caacctctgc                                                   20


<210> 19866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19866
aattttgaga cctttggcaa                                                   20


<210> 19867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19867
atgttcaatt ttgagacctt                                                   20


<210> 19868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19868
ttaatgacat gttcaatttt                                                   20


<210> 19869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19869
gcctatgtta aaaaggaaga                                                   20


<210> 19870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19870
ctttgcctat gttaaaaagg                                                   20


<210> 19871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19871
caactttgcc tatgttaaaa                                                   20


<210> 19872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19872
ccaactttgc ctatgttaaa                                                   20


<210> 19873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19873
atgttcatct acgccatctt                                                   20


<210> 19874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19874
catcggcctc ctgctcttcc                                                   20


<210> 19875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 19875
cttcctgcgt tgtttaacat                                                   20


<210> 19876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19876
gtctagtcaa aggagcaaag                                                   20


<210> 19877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19877
cgtctagtca aaggagcaaa                                                   20


<210> 19878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19878
acgtctagtc aaaggagcaa                                                   20


<210> 19879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19879
tacgtctagt caaaggagca                                                   20


<210> 19880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19880
aatcctacgt ctagtcaaag                                                   20


<210> 19881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19881
cgaatcctac gtctagtcaa                                                   20


<210> 19882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19882
ccgaatccta cgtctagtca                                                   20


<210> 19883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19883
gattggccga atcctacgtc                                                   20


<210> 19884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19884
gtgatccgtc ttgccaggat                                                   20


<210> 19885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19885
tccgagtgat ccgtcttgcc                                                   20


<210> 19886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19886
ttccgagtga tccgtcttgc                                                   20


<210> 19887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19887
tgtgtcccct accctgttcc                                                   20


<210> 19888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19888
tccacataca ggtatgtttc                                                   20


<210> 19889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19889
tattattttc ctccacatac                                                   20


<210> 19890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19890
ctattatttt cctccacata                                                   20


<210> 19891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19891
tttagagtca tcatttcagg                                                   20


<210> 19892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19892
ctgtttagag tcatcatttc                                                   20


<210> 19893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19893
actgtttaga gtcatcattt                                                   20


<210> 19894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19894
ttgacagata aaactgttta                                                   20


<210> 19895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19895
agttgacaga taaaactgtt                                                   20


<210> 19896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19896
attcataaga aatgagttga                                                   20


<210> 19897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19897
gtcttgaatt cataagaaat                                                   20


<210> 19898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19898
aaaaactgtc ttgaattcat                                                   20


<210> 19899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19899
tccagcctgg gcgacagagc                                                   20


<210> 19900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19900
gcactccagc ctgggcgaca                                                   20


<210> 19901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19901
ctgcactcca gcctgggcga                                                   20


<210> 19902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19902
gcgccactgc actccagcct                                                   20


<210> 19903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19903
cgcgccactg cactccagcc                                                   20


<210> 19904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19904
gagatcgcgc cactgcactc                                                   20


<210> 19905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19905
ggcggagctt gcagtgagcc                                                   20


<210> 19906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19906
cgggaggcgg agcttgcagt                                                   20


<210> 19907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19907
aacccgggag gcggagcttg                                                   20


<210> 19908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19908
tggcgtgaac ccgggaggcg                                                   20


<210> 19909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 19909
aatggcgtga acccgggagg                                                   20


<210> 19910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19910
gagaatggcg tgaacccggg                                                   20


<210> 19911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19911
ggagaatggc gtgaacccgg                                                   20


<210> 19912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19912
caggagaatg gcgtgaaccc                                                   20


<210> 19913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 19913
gcaggagaat ggcgtgaacc                                                   20


<210> 19914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19914
gggaggctga ggcaggagaa                                                   20


<210> 19915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19915
tactcgggag gctgaggcag                                                   20


<210> 19916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19916
gctactcggg aggctgaggc                                                   20


<210> 19917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19917
agctactcgg gaggctgagg                                                   20


<210> 19918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19918
cccagctact cgggaggctg                                                   20


<210> 19919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19919
tcccagctac tcgggaggct                                                   20


<210> 19920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19920
tgtagtccca gctactcggg                                                   20


<210> 19921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19921
ctgtagtccc agctactcgg                                                   20


<210> 19922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19922
gcctgtagtc ccagctactc                                                   20


<210> 19923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 19923
cgcctgtagt cccagctact                                                   20


<210> 19924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19924
gtagcgggcg cctgtagtcc                                                   20


<210> 19925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19925
ggcgtggtag cgggcgcctg                                                   20


<210> 19926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19926
aattagccgg gcgtggtagc                                                   20


<210> 19927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 19927
aaattagccg ggcgtggtag                                                   20


<210> 19928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19928
aaaaaattag ccgggcgtgg                                                   20


<210> 19929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19929
tacaaaaaat tagccgggcg                                                   20


<210> 19930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19930
aaaaatacaa aaaattagcc                                                   20


<210> 19931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 19931
taaaaataca aaaaattagc                                                   20


<210> 19932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19932
ctactaaaaa tacaaaaaat                                                   20


<210> 19933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19933
cgagaccatc ctggctaaca                                                   20


<210> 19934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19934
tcgagaccat cctggctaac                                                   20


<210> 19935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19935
tcaggagatc gagaccatcc                                                   20


<210> 19936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19936
gatcacgagg tcaggagatc                                                   20


<210> 19937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19937
cgggcggatc acgaggtcag                                                   20


<210> 19938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19938
ggcgggcgga tcacgaggtc                                                   20


<210> 19939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19939
aggcgggcgg atcacgaggt                                                   20


<210> 19940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19940
gccgaggcgg gcggatcacg                                                   20


<210> 19941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19941
ggccgaggcg ggcggatcac                                                   20


<210> 19942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 19942
ctttgggagg ccgaggcggg                                                   20


<210> 19943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19943
gcactttggg aggccgaggc                                                   20


<210> 19944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 19944
agcactttgg gaggccgagg                                                   20


<210> 19945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19945
cccagcactt tgggaggccg                                                   20


<210> 19946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19946
tcccagcact ttgggaggcc                                                   20


<210> 19947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19947
tgtaatccca gcactttggg                                                   20


<210> 19948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19948
ctgtaatccc agcactttgg                                                   20


<210> 19949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19949
gcctgtaatc ccagcacttt                                                   20


<210> 19950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19950
cgcctgtaat cccagcactt                                                   20


<210> 19951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19951
gtggctcacg cctgtaatcc                                                   20


<210> 19952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19952
actgtcttgg ccgggcacgg                                                   20


<210> 19953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 19953
ataactgtct tggccgggca                                                   20


<210> 19954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19954
ataaaataac tgtcttggcc                                                   20


<210> 19955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 19955
tataaaataa ctgtcttggc                                                   20


<210> 19956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19956
tcagtataaa ataactgtct                                                   20


<210> 19957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19957
cttttttaag taattgcatt                                                   20


<210> 19958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19958
gaatttctta atcctttttt                                                   20


<210> 19959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19959
taatgttagt catttctctt                                                   20


<210> 19960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19960
aaatgtcaca atggtaatgt                                                   20


<210> 19961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19961
aaaaggagaa aatgtcacaa                                                   20


<210> 19962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19962
cccatgaact tagtaaaaag                                                   20


<210> 19963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19963
ggcccatgaa cttagtaaaa                                                   20


<210> 19964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19964
tggcccatga acttagtaaa                                                   20


<210> 19965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19965
gaaaaaatgg cccatgaact                                                   20


<210> 19966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19966
actattatgg agggaaaaaa                                                   20


<210> 19967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19967
atgtaaaaca ctattatgga                                                   20


<210> 19968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19968
aatgtaaaac actattatgg                                                   20


<210> 19969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19969
aaatgtaaaa cactattatg                                                   20


<210> 19970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19970
taaaatgtaa aacactatta                                                   20


<210> 19971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19971
cttgaatttt ctatgtgagt                                                   20


<210> 19972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19972
gcttgaattt tctatgtgag                                                   20


<210> 19973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19973
attgcttgaa ttttctatgt                                                   20


<210> 19974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 19974
attttctttt tagcatttaa                                                   20


<210> 19975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19975
ggtgatttat attttctttt                                                   20


<210> 19976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19976
atagttattg ttgacatttc                                                   20


<210> 19977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19977
aatagttatt gttgacattt                                                   20


<210> 19978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19978
actcaaaaaa atattgataa                                                   20


<210> 19979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19979
cttgcacaga aaaatgtctg                                                   20


<210> 19980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19980
tgtgtgtaca tgtgcttgca                                                   20


<210> 19981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19981
aaataaatag gttacaaaaa                                                   20


<210> 19982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19982
gtcttgaaaa ataaataaat                                                   20


<210> 19983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19983
tgtcttgaaa aataaataaa                                                   20


<210> 19984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19984
tccagctttg gcgacagagc                                                   20


<210> 19985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19985
gcactccagc tttggcgaca                                                   20


<210> 19986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19986
ccgcactcca gctttggcga                                                   20


<210> 19987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19987
acaccaccgc actccagctt                                                   20


<210> 19988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19988
aagatcacac caccgcactc                                                   20


<210> 19989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 19989
tgcagagatt gcagtaggcc                                                   20


<210> 19990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19990
cgggatgcag agattgcagt                                                   20


<210> 19991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 19991
ccgggatgca gagattgcag                                                   20


<210> 19992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19992
atcccgggat gcagagattg                                                   20


<210> 19993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19993
tcatttgatc ccgggatgca                                                   20


<210> 19994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 19994
aatcatttga tcccgggatg                                                   20


<210> 19995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 19995
ctggagaatc atttgatccc                                                   20


<210> 19996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 19996
gctggagaat catttgatcc                                                   20


<210> 19997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 19997
tactctggag gctgaggctg                                                   20


<210> 19998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 19998
gctactctgg aggctgaggc                                                   20


<210> 19999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 19999
cccagctact ctggaggctg                                                   20


<210> 20000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20000
tcccagctac tctggaggct                                                   20


<210> 20001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20001
tgtagtccca gctactctgg                                                   20


<210> 20002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20002
ctgtagtccc agctactctg                                                   20


<210> 20003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20003
gcctgtagtc ccagctactc                                                   20


<210> 20004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20004
gtggcgcatg cctgtagtcc                                                   20


<210> 20005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20005
ggtgtggtgg cgcatgcctg                                                   20


<210> 20006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20006
caaaaattaa ccaggtgtgg                                                   20


<210> 20007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20007
acacaaaaat taaccaggtg                                                   20


<210> 20008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20008
caaaaacaca aaaattaacc                                                   20


<210> 20009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20009
ccaaaaacac aaaaattaac                                                   20


<210> 20010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20010
tgagaccagc ctggccaaca                                                   20


<210> 20011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20011
ttgagaccag cctggccaac                                                   20


<210> 20012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20012
tcagaagttt gagaccagcc                                                   20


<210> 20013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20013
tgaagtcaga agtttgagac                                                   20


<210> 20014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20014
tcacttgaag tcagaagttt                                                   20


<210> 20015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20015
gcgaaatcac ttgaagtcag                                                   20


<210> 20016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20016
tgggcgaaat cacttgaagt                                                   20


<210> 20017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20017
gaggtgggcg aaatcacttg                                                   20


<210> 20018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20018
gcacattggg aggccgaggt                                                   20


<210> 20019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20019
agcacattgg gaggccgagg                                                   20


<210> 20020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20020
cccagcacat tgggaggccg                                                   20


<210> 20021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20021
tcccagcaca ttgggaggcc                                                   20


<210> 20022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20022
tataatccca gcacattggg                                                   20


<210> 20023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20023
ctataatccc agcacattgg                                                   20


<210> 20024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20024
gcctataatc ccagcacatt                                                   20


<210> 20025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20025
cgcctataat cccagcacat                                                   20


<210> 20026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20026
gtggctcacg cctataatcc                                                   20


<210> 20027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20027
aggttacagg ctgggcactg                                                   20


<210> 20028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20028
aataaaatag gttacaggct                                                   20


<210> 20029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20029
aaataaaata ggttacaggc                                                   20


<210> 20030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20030
aagtaaataa aataggttac                                                   20


<210> 20031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20031
aaagtaaata aaataggtta                                                   20


<210> 20032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20032
acatataaag taaataaaat                                                   20


<210> 20033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20033
gacatataaa gtaaataaaa                                                   20


<210> 20034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20034
aactatctcc atgacatata                                                   20


<210> 20035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20035
tcaatttgtg gttattttga                                                   20


<210> 20036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20036
cttcaatttg tggttatttt                                                   20


<210> 20037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20037
aaatgctagt cttcaatttg                                                   20


<210> 20038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20038
aatggaaaca gtataaatgc                                                   20


<210> 20039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20039
ttcagtaaca aaaatggaaa                                                   20


<210> 20040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20040
attcatttca gtaacaaaaa                                                   20


<210> 20041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20041
agctatttag atattcattt                                                   20


<210> 20042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20042
attaggagaa catagctatt                                                   20


<210> 20043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20043
ctcatgcaat taggagaaca                                                   20


<210> 20044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20044
aaaagtactc atgcaattag                                                   20


<210> 20045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20045
taaaaagtac tcatgcaatt                                                   20


<210> 20046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20046
ttaaaaagta ctcatgcaat                                                   20


<210> 20047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20047
tctattaaca tattattaaa                                                   20


<210> 20048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20048
catatatata ctgttgaccc                                                   20


<210> 20049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20049
atatagtatg tgtgtatata                                                   20


<210> 20050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20050
atatagtatg tgtatatata                                                   20


<210> 20051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20051
tatactgtat atagtatata                                                   20


<210> 20052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20052
tgtatactat atactgtata                                                   20


<210> 20053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20053
gtatagtata tgtatatgta                                                   20


<210> 20054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20054
tatatgtata tgtatatgta                                                   20


<210> 20055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20055
gtactgtata tacgtatact                                                   20


<210> 20056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20056
tgctatatat acatactata                                                   20


<210> 20057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20057
tgcatactat atgctatata                                                   20


<210> 20058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20058
tatgcatact atatgctata                                                   20


<210> 20059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20059
tatgcatact atatgctata                                                   20


<210> 20060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20060
cgcatactct atactatata                                                   20


<210> 20061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20061
catactctat actatatata                                                   20


<210> 20062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20062
catactctat actatatata                                                   20


<210> 20063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20063
catactctat actatatata                                                   20


<210> 20064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20064
catactctat actatatata                                                   20


<210> 20065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20065
catactctat actatatata                                                   20


<210> 20066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20066
catactctat actatatata                                                   20


<210> 20067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20067
catactctat actatatata                                                   20


<210> 20068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20068
catactatgt atatagtata                                                   20


<210> 20069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20069
cacatactat gtatatagta                                                   20


<210> 20070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20070
acacacacat actatgtata                                                   20


<210> 20071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20071
aggctttctg gagataggtt                                                   20


<210> 20072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20072
agtacaggct ttctggagat                                                   20


<210> 20073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20073
tagtacaggc tttctggaga                                                   20


<210> 20074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20074
taattagtac aggctttctg                                                   20


<210> 20075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20075
gttaattagt acaggctttc                                                   20


<210> 20076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20076
ttagaaatgt taattagtac                                                   20


<210> 20077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20077
attagaaatg ttaattagta                                                   20


<210> 20078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20078
ctgccattag aaatgttaat                                                   20


<210> 20079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20079
gcactatcat atactgccat                                                   20


<210> 20080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20080
ctgttgaatg tgtaaagtat                                                   20


<210> 20081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20081
tcaatactgt tgaatgtgta                                                   20


<210> 20082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20082
aaaactataa agaagaatgg                                                   20


<210> 20083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20083
taaaaaacta taaagaagaa                                                   20


<210> 20084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20084
tttggtaaaa aactataaag                                                   20


<210> 20085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20085
ttttttggta aaaaactata                                                   20


<210> 20086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20086
caaatgtcat gaaaattttt                                                   20


<210> 20087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20087
atgcaaataa attacaatag                                                   20


<210> 20088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20088
aaaatgcaaa taaattacaa                                                   20


<210> 20089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20089
acaaaacaca aggaaaattg                                                   20


<210> 20090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20090
atacaaaata acaaaacaca                                                   20


<210> 20091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20091
gatacaaaat aacaaaacac                                                   20


<210> 20092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20092
gaagttaaaa acaaccaata                                                   20


<210> 20093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20093
agaagttaaa aacaaccaat                                                   20


<210> 20094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20094
ccaaactaag ccaaaaacag                                                   20


<210> 20095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20095
ataccaaact aagccaaaaa                                                   20


<210> 20096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20096
acatgggcaa ataccaaact                                                   20


<210> 20097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20097
aaaaatccca atagacacat                                                   20


<210> 20098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20098
taaaaatccc aatagacaca                                                   20


<210> 20099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20099
gaatatagta aaaatcccaa                                                   20


<210> 20100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20100
cttataaatt aataagaata                                                   20


<210> 20101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20101
aattgttctt ataaattaat                                                   20


<210> 20102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20102
gaaaggatca atactttaaa                                                   20


<210> 20103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20103
ataacagtta aggccgagaa                                                   20


<210> 20104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20104
cataacagtt aaggccgaga                                                   20


<210> 20105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20105
tttacataac agttaaggcc                                                   20


<210> 20106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20106
aaatgtttac ataacagtta                                                   20


<210> 20107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20107
gaaatgttta cataacagtt                                                   20


<210> 20108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20108
taggtgaaat gtttacataa                                                   20


<210> 20109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20109
aaggttgaaa gacaaaaaat                                                   20


<210> 20110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20110
aaaggttgaa agacaaaaaa                                                   20


<210> 20111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20111
catcataaat aaaaggttga                                                   20


<210> 20112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20112
aaaaaatcat cataaataaa                                                   20


<210> 20113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20113
gaaaaaatca tcataaataa                                                   20


<210> 20114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20114
aaaaaacaaa atattctttg                                                   20


<210> 20115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20115
aaaaaaacaa aatattcttt                                                   20


<210> 20116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20116
caaaaaaaca aaatattctt                                                   20


<210> 20117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20117
agccaaaaaa aaaaatgaag                                                   20


<210> 20118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20118
taaagccaaa aaaaaaaatg                                                   20


<210> 20119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20119
atgcaaaaca caaatttgta                                                   20


<210> 20120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20120
catataacca tatactctta                                                   20


<210> 20121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20121
tagtaggaaa tatgtggaaa                                                   20


<210> 20122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20122
agattctagt aggaaatatg                                                   20


<210> 20123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20123
ttaaaaaaaa agattctagt                                                   20


<210> 20124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20124
gttaaaaaaa aagattctag                                                   20


<210> 20125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20125
aaagttaaaa aaaaagattc                                                   20


<210> 20126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20126
aaaatctaaa gttaaaaaaa                                                   20


<210> 20127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20127
atcacatgaa tcaaaatcta                                                   20


<210> 20128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20128
ttaccaattt actgtgtgaa                                                   20


<210> 20129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20129
aagctcagtg ggtttgaaga                                                   20


<210> 20130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20130
aaaagctcag tgggtttgaa                                                   20


<210> 20131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20131
ataaaagctc agtgggtttg                                                   20


<210> 20132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20132
ttcaaatata aaagctcagt                                                   20


<210> 20133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20133
gttcaaatat aaaagctcag                                                   20


<210> 20134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20134
actgttcaaa tataaaagct                                                   20


<210> 20135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20135
ataaaactgt tcaaatataa                                                   20


<210> 20136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20136
ctgcaaaata ttaagacata                                                   20


<210> 20137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20137
ggcttattct gcaaaatatt                                                   20


<210> 20138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20138
aaaattaggg tgacaagagg                                                   20


<210> 20139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20139
aagaaaatta gggtgacaag                                                   20


<210> 20140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20140
gaagaaaatt agggtgacaa                                                   20


<210> 20141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20141
tggaagaaaa ttagggtgac                                                   20


<210> 20142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20142
attcatctgg aagaaaatta                                                   20


<210> 20143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20143
aattcatctg gaagaaaatt                                                   20


<210> 20144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20144
aaattcatct ggaagaaaat                                                   20


<210> 20145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20145
atgattctaa attcatctgg                                                   20


<210> 20146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20146
taaatgattc taaattcatc                                                   20


<210> 20147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20147
taaatagaca aaaacaatat                                                   20


<210> 20148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20148
tatgtagtgt gggtaataaa                                                   20


<210> 20149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20149
tgagtctttt tatgtagtgt                                                   20


<210> 20150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20150
atgagtcttt ttatgtagtg                                                   20


<210> 20151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20151
tatcaatgag tctttttatg                                                   20


<210> 20152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20152
aattcaagga aaatatcaat                                                   20


<210> 20153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20153
tttattaatc tataaattca                                                   20


<210> 20154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20154
atttattaat ctataaattc                                                   20


<210> 20155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20155
aagcttctct cattgtaatt                                                   20


<210> 20156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20156
ggattgtcat gtacttagat                                                   20


<210> 20157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20157
tgaaaggatt gtcatgtact                                                   20


<210> 20158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20158
agaaagctaa aataattgaa                                                   20


<210> 20159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20159
aagaaagcta aaataattga                                                   20


<210> 20160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20160
aaactttagg atataaaaga                                                   20


<210> 20161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20161
aagaaaactt taggatataa                                                   20


<210> 20162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20162
agacttctga agaaaacttt                                                   20


<210> 20163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20163
gagacttctg aagaaaactt                                                   20


<210> 20164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20164
tttatcatat gagacttctg                                                   20


<210> 20165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20165
taataataac tttatcatat                                                   20


<210> 20166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20166
tcacaattgc aataaaaata                                                   20


<210> 20167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20167
atcttataca tgaaaaaaat                                                   20


<210> 20168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20168
aaattcaatt agagttcaaa                                                   20


<210> 20169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20169
taaattcaat tagagttcaa                                                   20


<210> 20170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20170
actaaaaata aattcaatta                                                   20


<210> 20171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20171
caactaaaaa taaattcaat                                                   20


<210> 20172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20172
aacttgttca tatattgaaa                                                   20


<210> 20173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20173
agaacttgtt catatattga                                                   20


<210> 20174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20174
tgaccttctt catataatga                                                   20


<210> 20175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20175
gtacatatat aaaaacaatg                                                   20


<210> 20176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20176
aggtacatat ataaaaacaa                                                   20


<210> 20177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20177
aattagataa gaaaacagag                                                   20


<210> 20178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20178
caattagata agaaaacaga                                                   20


<210> 20179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20179
tgcaattaga taagaaaaca                                                   20


<210> 20180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20180
aatgcaatta gataagaaaa                                                   20


<210> 20181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20181
gttggccaat gcaattagat                                                   20


<210> 20182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20182
gtgttgttgg ccaatgcaat                                                   20


<210> 20183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20183
atccctgttt ttagtgttgt                                                   20


<210> 20184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20184
gcctgtatca tccctgtttt                                                   20


<210> 20185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20185
ttaagtcagg aaaaaaaaaa                                                   20


<210> 20186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20186
tattaagtca ggaaaaaaaa                                                   20


<210> 20187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20187
gaaagcattc ctattaagtc                                                   20


<210> 20188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20188
tgaaagcatt cctattaagt                                                   20


<210> 20189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20189
attctgaaag cattcctatt                                                   20


<210> 20190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20190
actaacaaaa atgattctga                                                   20


<210> 20191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20191
aaatgtatta aaatttaggt                                                   20


<210> 20192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20192
aagaaaatgt attaaaattt                                                   20


<210> 20193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20193
taagaaaatg tattaaaatt                                                   20


<210> 20194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20194
agtcatacca aaattgatat                                                   20


<210> 20195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20195
gaaaagcata ttatcaccag                                                   20


<210> 20196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20196
ttggaaaagc atattatcac                                                   20


<210> 20197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20197
taaaatcaat aattttggaa                                                   20


<210> 20198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20198
gcatttaaaa tcaataattt                                                   20


<210> 20199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20199
tgagtgccac ataacagagt                                                   20


<210> 20200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20200
aaattgagtg ccacataaca                                                   20


<210> 20201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20201
taaaattgag tgccacataa                                                   20


<210> 20202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20202
tgacttagaa tcataaaatt                                                   20


<210> 20203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20203
aggttcaagg ttgcatgact                                                   20


<210> 20204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20204
tatcaatctg aaaaggttca                                                   20


<210> 20205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20205
ttatcaatct gaaaaggttc                                                   20


<210> 20206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20206
aacaggttat caatctgaaa                                                   20


<210> 20207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20207
caacaggtta tcaatctgaa                                                   20


<210> 20208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20208
ttactacaag tttaatcaac                                                   20


<210> 20209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20209
attactacaa gtttaatcaa                                                   20


<210> 20210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20210
gagattatag agattactac                                                   20


<210> 20211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20211
tttaagagag agagattata                                                   20


<210> 20212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20212
cttttaagag agagagatta                                                   20


<210> 20213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20213
ttataaactt ttaagagaga                                                   20


<210> 20214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20214
aattataaac ttttaagaga                                                   20


<210> 20215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20215
agaattataa acttttaaga                                                   20


<210> 20216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20216
ttagaattat aaacttttaa                                                   20


<210> 20217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20217
ttttagaatt ataaactttt                                                   20


<210> 20218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20218
tttaggattg tatttctttt                                                   20


<210> 20219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20219
catatcttgc aaagtatttt                                                   20


<210> 20220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20220
acatatcttg caaagtattt                                                   20


<210> 20221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20221
ttattttcac atatcttgca                                                   20


<210> 20222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20222
ttcctataca ttcattgcca                                                   20


<210> 20223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20223
gtgttcatgt ctgtgaataa                                                   20


<210> 20224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20224
aatcattcct caaccagcca                                                   20


<210> 20225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20225
aatgccaatc attcctcaac                                                   20


<210> 20226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20226
tttacagctt aatacttcac                                                   20


<210> 20227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20227
aatgccagtt ttatttttta                                                   20


<210> 20228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20228
gttaagatct ctagaaatgc                                                   20


<210> 20229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20229
taaagtgaag ttaagatctc                                                   20


<210> 20230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20230
ccagaattta aagtgaagtt                                                   20


<210> 20231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20231
ttcttccaga atttaaagtg                                                   20


<210> 20232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20232
gaaaattctt ccagaattta                                                   20


<210> 20233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20233
tgaatttgtg aaaattcttc                                                   20


<210> 20234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20234
ttaatgataa tattaatagc                                                   20


<210> 20235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20235
ttgattaatg ataatattaa                                                   20


<210> 20236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20236
cttctggttt tagcacatgt                                                   20


<210> 20237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20237
tctgaaataa cttctggttt                                                   20


<210> 20238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20238
gttgaatctg aaataacttc                                                   20


<210> 20239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20239
gtttatatat agctgtgtct                                                   20


<210> 20240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20240
ctagttacca tgtttatata                                                   20


<210> 20241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20241
caatattacc tttgcaaaac                                                   20


<210> 20242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20242
aaattatact tgttgatatt                                                   20


<210> 20243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20243
aaatatttct atctattaga                                                   20


<210> 20244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20244
caaatatttc tatctattag                                                   20


<210> 20245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20245
agccaaatat ttctatctat                                                   20


<210> 20246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20246
ggtttacact acaggcccca                                                   20


<210> 20247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20247
tgtttctggg tttacactac                                                   20


<210> 20248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20248
gtgtttctgg gtttacacta                                                   20


<210> 20249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20249
tctcatacta cagtgtttct                                                   20


<210> 20250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20250
ctctcatact acagtgtttc                                                   20


<210> 20251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20251
aatatctgtc tctcatacta                                                   20


<210> 20252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20252
aagaatgaaa aaatcctaaa                                                   20


<210> 20253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20253
tgagtaagtc agtacaatga                                                   20


<210> 20254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20254
aaatttactc ttgagtaagt                                                   20


<210> 20255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20255
acacaaattt actcttgagt                                                   20


<210> 20256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20256
ttgaacacaa atttactctt                                                   20


<210> 20257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20257
aacttcactt atgctcaagg                                                   20


<210> 20258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20258
ctaaacttca cttatgctca                                                   20


<210> 20259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20259
gctaaacttc acttatgctc                                                   20


<210> 20260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20260
cagattttat tttttgagta                                                   20


<210> 20261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20261
tttttcagat tttatttttt                                                   20


<210> 20262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20262
aggtaagaat atttattttt                                                   20


<210> 20263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20263
tgattatctc cattgtaggt                                                   20


<210> 20264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20264
gttgtgatta tctccattgt                                                   20


<210> 20265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20265
ggttgtgatt atctccattg                                                   20


<210> 20266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20266
atggaatatt tttgattttg                                                   20


<210> 20267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20267
actactactt cactgtagga                                                   20


<210> 20268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20268
agacactact acttcactgt                                                   20


<210> 20269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20269
cagacactac tacttcactg                                                   20


<210> 20270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20270
gtgctaaaac tgatctccct                                                   20


<210> 20271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20271
ttttataatc cttttcactg                                                   20


<210> 20272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20272
gtttttataa tccttttcac                                                   20


<210> 20273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20273
agttttatat tggataaatg                                                   20


<210> 20274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20274
atatgactga agttttatat                                                   20


<210> 20275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20275
tcaaagtcaa catatgactg                                                   20


<210> 20276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20276
atggtagaaa aggagggtca                                                   20


<210> 20277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20277
accatgatgg tagaaaagga                                                   20


<210> 20278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20278
aaccatgatg gtagaaaagg                                                   20


<210> 20279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20279
taaccatgat ggtagaaaag                                                   20


<210> 20280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20280
ggtaaccatg atggtagaaa                                                   20


<210> 20281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20281
tggtaaccat gatggtagaa                                                   20


<210> 20282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20282
caacatggta accatgatgg                                                   20


<210> 20283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20283
tctcaacatg gtaaccatga                                                   20


<210> 20284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20284
ggttcttatc tgtctcaaca                                                   20


<210> 20285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20285
agcctttgat attagtatca                                                   20


<210> 20286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20286
acaaatcaag cctttgatat                                                   20


<210> 20287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20287
atttgaccta gtgacaaatc                                                   20


<210> 20288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20288
ccaaggatgt atatttgacc                                                   20


<210> 20289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20289
tctttgcaga acaaaatcca                                                   20


<210> 20290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20290
ttctttgcag aacaaaatcc                                                   20


<210> 20291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20291
atattattct tatttctttg                                                   20


<210> 20292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20292
atttctggat aatacttgaa                                                   20


<210> 20293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20293
taatgcacat ctttaatttc                                                   20


<210> 20294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20294
atatatatat ctttagcata                                                   20


<210> 20295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20295
taaaaaaata tatatatctt                                                   20


<210> 20296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20296
aaagccaatt cctcgaccag                                                   20


<210> 20297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20297
aaaagccaat tcctcgacca                                                   20


<210> 20298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20298
caaaagccaa ttcctcgacc                                                   20


<210> 20299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20299
acaaaagcca attcctcgac                                                   20


<210> 20300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20300
tggggtccaa gaagccacaa                                                   20


<210> 20301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20301
tgaaaaagct ggggtccaag                                                   20


<210> 20302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20302
caatgaaaaa gctggggtcc                                                   20


<210> 20303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20303
ataatgcaat gaaaaagctg                                                   20


<210> 20304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20304
tataatgcaa tgaaaaagct                                                   20


<210> 20305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20305
ctataatgca atgaaaaagc                                                   20


<210> 20306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20306
aatactataa tgcaatgaaa                                                   20


<210> 20307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20307
tctttatgac agaagaacag                                                   20


<210> 20308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20308
acatctttat gacagaagaa                                                   20


<210> 20309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20309
tcaagacatc tttatgacag                                                   20


<210> 20310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20310
aggtcaagac atctttatga                                                   20


<210> 20311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20311
gtttctttac cttggaggtc                                                   20


<210> 20312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20312
tgtttgtttc tttaccttgg                                                   20


<210> 20313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20313
ttgtttgttt ctttaccttg                                                   20


<210> 20314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20314
ttttgtttgt ttctttacct                                                   20


<210> 20315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20315
aaagatgtag acaatgattc                                                   20


<210> 20316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20316
tagtaatcta tagaaagatg                                                   20


<210> 20317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20317
ctattttagt aatctataga                                                   20


<210> 20318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20318
taacctattt tagtaatcta                                                   20


<210> 20319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20319
taacacattt taacctattt                                                   20


<210> 20320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20320
tttaagatat attttatgta                                                   20


<210> 20321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20321
ctacacatat gtaattattt                                                   20


<210> 20322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20322
tgcacattta actgtgtttg                                                   20


<210> 20323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20323
tatgcacatt taactgtgtt                                                   20


<210> 20324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20324
tagcacacca aaagaatatt                                                   20


<210> 20325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20325
aacactgatt agcacaccaa                                                   20


<210> 20326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20326
tagtttaaaa caacactgat                                                   20


<210> 20327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20327
ataaaaaaga taaaagtaca                                                   20


<210> 20328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20328
ctagcagata aaaaagataa                                                   20


<210> 20329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20329
aagacagcta gcagataaaa                                                   20


<210> 20330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20330
agtcacagta agacagctag                                                   20


<210> 20331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20331
aaaagtcaca gtaagacagc                                                   20


<210> 20332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20332
caataaaagt cacagtaaga                                                   20


<210> 20333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20333
ttagcaataa aagtcacagt                                                   20


<210> 20334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20334
tttcttagca ataaaagtca                                                   20


<210> 20335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20335
acaaattttc ttagcaataa                                                   20


<210> 20336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20336
ttaattctta caaattttct                                                   20


<210> 20337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20337
tatttgccaa atcatcaaag                                                   20


<210> 20338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20338
aaatatttgc caaatcatca                                                   20


<210> 20339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20339
tggctcccta ttctttataa                                                   20


<210> 20340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20340
atgggagttc actcatgatt                                                   20


<210> 20341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20341
tttgtagtaa ttgtgaatgg                                                   20


<210> 20342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20342
tctttgtagt aattgtgaat                                                   20


<210> 20343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20343
ctctttgtag taattgtgaa                                                   20


<210> 20344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20344
taggtatttt attctctttg                                                   20


<210> 20345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20345
cccttgtaag ttggattcct                                                   20


<210> 20346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20346
tcccttgtaa gttggattcc                                                   20


<210> 20347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20347
ccttcacatc ccttgtaagt                                                   20


<210> 20348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20348
aggtccttca catcccttgt                                                   20


<210> 20349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20349
gtttgtagtt ctccttgaag                                                   20


<210> 20350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20350
ggtttgtagt tctccttgaa                                                   20


<210> 20351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20351
gtggtttgta gttctccttg                                                   20


<210> 20352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20352
tttcgctgag cagtggtttg                                                   20


<210> 20353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20353
tcttttattt cgctgagcag                                                   20


<210> 20354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20354
tcctctttta tttcgctgag                                                   20


<210> 20355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20355
gtgtcctctt ttatttcgct                                                   20


<210> 20356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20356
agtcttccta tccatgagca                                                   20


<210> 20357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20357
tattgagtct tcctatccat                                                   20


<210> 20358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20358
aatgccattt tcatgatatt                                                   20


<210> 20359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20359
aatttataaa ttaccttggg                                                   20


<210> 20360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20360
ttgaatttat aaattacctt                                                   20


<210> 20361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20361
attgaattta taaattacct                                                   20


<210> 20362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20362
cagtggtagc ttgatgggga                                                   20


<210> 20363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20363
aagtcagtgg tagcttgatg                                                   20


<210> 20364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20364
aaagtcagtg gtagcttgat                                                   20


<210> 20365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20365
gaaagtcagt ggtagcttga                                                   20


<210> 20366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20366
tttgtgaaga aagtcagtgg                                                   20


<210> 20367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20367
aattttgtga agaaagtcag                                                   20


<210> 20368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20368
tccaattttg tgaagaaagt                                                   20


<210> 20369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20369
tttttccaat tttgtgaaga                                                   20


<210> 20370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20370
agtttttttc caattttgtg                                                   20


<210> 20371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20371
gttccatatg aactttaaag                                                   20


<210> 20372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20372
ttggttccat atgaacttta                                                   20


<210> 20373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20373
tggctatgca ggctcttttt                                                   20


<210> 20374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20374
taggattatc ttggctatgc                                                   20


<210> 20375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20375
ttaggattat cttggctatg                                                   20


<210> 20376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20376
ctttttgctt aggattatct                                                   20


<210> 20377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20377
cagctttgtt ctttttgctt                                                   20


<210> 20378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20378
ccagctttgt tctttttgct                                                   20


<210> 20379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20379
gtcaggtagt gtgacgcctc                                                   20


<210> 20380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20380
tagtatagtt tgaagtcagg                                                   20


<210> 20381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20381
ttgtagtata gtttgaagtc                                                   20


<210> 20382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20382
cttgtagtat agtttgaagt                                                   20


<210> 20383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20383
tagccttgta gtatagtttg                                                   20


<210> 20384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20384
gttactgtag ccttgtagta                                                   20


<210> 20385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20385
ttttggttac tgtagccttg                                                   20


<210> 20386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20386
ccatgctgtt ttggttactg                                                   20


<210> 20387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20387
gtaccagtac catgctgttt                                                   20


<210> 20388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20388
gtatgtatct gttttggtac                                                   20


<210> 20389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20389
gttggtgtat gtatctgttt                                                   20


<210> 20390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20390
aggcctctgt tctgttctgt                                                   20


<210> 20391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20391
gatgtgtagt gttatttctg                                                   20


<210> 20392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20392
agatgtgtag tgttatttct                                                   20


<210> 20393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20393
atcagatggt tgtagatgtg                                                   20


<210> 20394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20394
tgtcaaggat cagatggttg                                                   20


<210> 20395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20395
gaggtttgtc aaggatcaga                                                   20


<210> 20396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20396
ttgtgaggtt tgtcaaggat                                                   20


<210> 20397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20397
tgtttttgtg aggtttgtca                                                   20


<210> 20398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20398
ttgtttttgt gaggtttgtc                                                   20


<210> 20399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20399
ccccgttgct tgtttttgtg                                                   20


<210> 20400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20400
tccccgttgc ttgtttttgt                                                   20


<210> 20401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20401
gcatcattta ttaaataggg                                                   20


<210> 20402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20402
ccagcatcat ttattaaata                                                   20


<210> 20403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20403
cccagcatca tttattaaat                                                   20


<210> 20404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20404
tcccagcatc atttattaaa                                                   20


<210> 20405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20405
atatggctag ccagttttcc                                                   20


<210> 20406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20406
actttctaca tatggctagc                                                   20


<210> 20407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20407
ttcaactttc tacatatggc                                                   20


<210> 20408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20408
cagtttcaac tttctacata                                                   20


<210> 20409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20409
caaggtgtaa ggaagggatc                                                   20


<210> 20410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20410
tttgtacaag gtgtaaggaa                                                   20


<210> 20411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20411
ttttgtacaa ggtgtaagga                                                   20


<210> 20412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20412
tttttgtaca aggtgtaagg                                                   20


<210> 20413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20413
taatttttgt acaaggtgta                                                   20


<210> 20414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20414
ttaatttttg tacaaggtgt                                                   20


<210> 20415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20415
cttgagttaa tttttgtaca                                                   20


<210> 20416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20416
tcttgagtta atttttgtac                                                   20


<210> 20417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20417
ttaagtcttt aatccatctt                                                   20


<210> 20418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20418
tggttttagg tcttacattt                                                   20


<210> 20419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20419
tctagggttt ttatggtttt                                                   20


<210> 20420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20420
ttctagggtt tttatggttt                                                   20


<210> 20421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20421
agtttcttct agggttttta                                                   20


<210> 20422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20422
attgcctaga gtttcttcta                                                   20


<210> 20423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20423
tattgcctag agtttcttct                                                   20


<210> 20424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20424
atattgccta gagtttcttc                                                   20


<210> 20425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20425
gtcctgaatg atattgccta                                                   20


<210> 20426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20426
atgtcctgaa tgatattgcc                                                   20


<210> 20427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20427
cttttggtgt tttagtcatg                                                   20


<210> 20428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20428
tgccattgct tttggtgttt                                                   20


<210> 20429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20429
gcttttgttg ccattgcttt                                                   20


<210> 20430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20430
tagatcccat ttgtctgttt                                                   20


<210> 20431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20431
cagaagctct ttagtttaat                                                   20


<210> 20432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20432
tttgctttgc agaagctctt                                                   20


<210> 20433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20433
tagtttcttt tgctttgcag                                                   20


<210> 20434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20434
tgatagtttc ttttgctttg                                                   20


<210> 20435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20435
ttgcctgttc actctgatga                                                   20


<210> 20436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20436
aaaattttct cccattctgt                                                   20


<210> 20437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20437
aaaaattttc tcccattctg                                                   20


<210> 20438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20438
atattagccc ttttgtcaga                                                   20


<210> 20439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20439
ctggatatta gcccttttgt                                                   20


<210> 20440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20440
tctttgtaga ttctggatat                                                   20


<210> 20441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20441
tttaagttct ttgtagattc                                                   20


<210> 20442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20442
aaatttgttt aagttctttg                                                   20


<210> 20443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20443
tttttcttgt aaatttgttt                                                   20


<210> 20444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20444
cctttgccca ctttttgatg                                                   20


<210> 20445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20445
atcctttgcc cactttttga                                                   20


<210> 20446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20446
cataaatgtc ttcttttgag                                                   20


<210> 20447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20447
ctgcataaat gtcttctttt                                                   20


<210> 20448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20448
gcattttttc atatgtctgt                                                   20


<210> 20449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20449
ctctgatgac cagtgatgat                                                   20


<210> 20450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20450
atttgtgttt ctctgatgac                                                   20


<210> 20451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20451
catgaggtgg tatctcattg                                                   20


<210> 20452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20452
ccattctaat tggcatgagg                                                   20


<210> 20453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20453
ttgccattct aattggcatg                                                   20


<210> 20454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20454
attgccattc taattggcat                                                   20


<210> 20455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20455
ttagtgattg ccattctaat                                                   20


<210> 20456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20456
tctgttgttt cctgactttt                                                   20


<210> 20457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20457
cactctcacc aacagtgtaa                                                   20


<210> 20458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20458
ctattttaca ctctcaccaa                                                   20


<210> 20459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20459
catcacactg tcttccacaa                                                   20


<210> 20460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20460
tttctagttt tagattcttg                                                   20


<210> 20461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20461
atttctagtt ttagattctt                                                   20


<210> 20462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20462
tcaaatggta tttctagttt                                                   20


<210> 20463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20463
gctgggtcaa atggtatttc                                                   20


<210> 20464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20464
aatgagattg ctgggtcaaa                                                   20


<210> 20465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20465
tacccagtaa tgagattgct                                                   20


<210> 20466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20466
atacccagta atgagattgc                                                   20


<210> 20467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20467
ttgagtatat acccagtaat                                                   20


<210> 20468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20468
caatcccttg agtatatacc                                                   20


<210> 20469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20469
agcatgattt acaatccctt                                                   20


<210> 20470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20470
atatgcatgt gtctttatag                                                   20


<210> 20471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20471
tacatatgca tgtgtcttta                                                   20


<210> 20472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20472
caagtctttg ctattgtgaa                                                   20


<210> 20473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20473
tggacatttg ggttggttcc                                                   20


<210> 20474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20474
ttattgatgg acatttgggt                                                   20


<210> 20475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20475
tctattattg atggacattt                                                   20


<210> 20476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20476
gtctattatt gatggacatt                                                   20


<210> 20477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20477
tttatccagt ctattattga                                                   20


<210> 20478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20478
tatgccacat tttctttatc                                                   20


<210> 20479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20479
tatggctgca tagtattcca                                                   20


<210> 20480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20480
catccttttt tatggctgca                                                   20


<210> 20481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20481
catgaactca tcctttttta                                                   20


<210> 20482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20482
cttcatgcat gtccctacaa                                                   20


<210> 20483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20483
gcttcatgca tgtccctaca                                                   20


<210> 20484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20484
ttgctgagaa tgatggtttc                                                   20


<210> 20485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20485
tgatattttg ctgagaatga                                                   20


<210> 20486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20486
cgtccttgtg atattttgct                                                   20


<210> 20487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20487
gagtgagaac atgcagagtt                                                   20


<210> 20488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20488
cttatgagtg agaacatgca                                                   20


<210> 20489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20489
cacttatgag tgagaacatg                                                   20


<210> 20490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20490
ttcaactccc acttatgagt                                                   20


<210> 20491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20491
attgttcaac tcccacttat                                                   20


<210> 20492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20492
cccaaccccc taactgcccc                                                   20


<210> 20493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20493
ctcctaagta atccctccca                                                   20


<210> 20494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20494
ttacattagg tatttctcct                                                   20


<210> 20495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20495
atcaactcat catttacatt                                                   20


<210> 20496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20496
aatcaactca tcatttacat                                                   20


<210> 20497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20497
taggtataca tgtaccatgt                                                   20


<210> 20498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20498
aacatgcagg tttgttacat                                                   20


<210> 20499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20499
aaacatgcag gtttgttaca                                                   20


<210> 20500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20500
ggtacatgtg caaaacatgc                                                   20


<210> 20501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20501
gggtacatgt gcaaaacatg                                                   20


<210> 20502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20502
ttattatact ttaagttcta                                                   20


<210> 20503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20503
attattatac tttaagttct                                                   20


<210> 20504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20504
tattattata ctttaagttc                                                   20


<210> 20505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20505
tttttttatt attatacttt                                                   20


<210> 20506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20506
acaattttgg ttattgtatg                                                   20


<210> 20507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20507
atataaaatt aatacaattt                                                   20


<210> 20508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20508
ttttttatgt aaaggaataa                                                   20


<210> 20509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20509
tatattcatt ttttatgtaa                                                   20


<210> 20510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20510
ttatattcat tttttatgta                                                   20


<210> 20511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20511
agaaatgtat attatcattt                                                   20


<210> 20512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20512
agtttcttga aatagagata                                                   20


<210> 20513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20513
tcaaagagtt tcttgaaata                                                   20


<210> 20514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20514
agtcaaagag tttcttgaaa                                                   20


<210> 20515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20515
gaattaaaaa ggtagtcaaa                                                   20


<210> 20516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20516
tagaattaaa aaggtagtca                                                   20


<210> 20517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20517
tttatttaga attaaaaagg                                                   20


<210> 20518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20518
tcctttattt agaattaaaa                                                   20


<210> 20519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20519
atcctttatt tagaattaaa                                                   20


<210> 20520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20520
ttatgttgaa atcctttatt                                                   20


<210> 20521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20521
gataatgttg acatccaata                                                   20


<210> 20522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20522
cagtacctag aaatctatca                                                   20


<210> 20523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20523
tcagtaccta gaaatctatc                                                   20


<210> 20524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20524
ttgataactt cctcagtacc                                                   20


<210> 20525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20525
atgataattg ataacttcct                                                   20


<210> 20526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20526
attggaaagt ccttcagttt                                                   20


<210> 20527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20527
aattggaaag tccttcagtt                                                   20


<210> 20528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20528
taatcaattg gaaagtcctt                                                   20


<210> 20529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20529
cttttatgta atcaattgga                                                   20


<210> 20530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20530
ttttctttta tgtaatcaat                                                   20


<210> 20531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20531
tatttactgt tgaattttaa                                                   20


<210> 20532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20532
ttccagtcaa aaacctcatt                                                   20


<210> 20533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20533
ttgtaagatt taggcttttc                                                   20


<210> 20534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20534
agcccccctt tgtaagattt                                                   20


<210> 20535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20535
tagcccccct ttgtaagatt                                                   20


<210> 20536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20536
agcttctagc ccccctttgt                                                   20


<210> 20537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20537
aagggagcaa ctgaagcttc                                                   20


<210> 20538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20538
gagaacaaag ggagcaactg                                                   20


<210> 20539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20539
aaattagcag agaacaaagg                                                   20


<210> 20540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20540
agaaattagc agagaacaaa                                                   20


<210> 20541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20541
aagaaattag cagagaacaa                                                   20


<210> 20542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20542
taagaaatta gcagagaaca                                                   20


<210> 20543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20543
gctaacttaa gaaattagca                                                   20


<210> 20544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20544
cagctaactt aagaaattag                                                   20


<210> 20545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20545
ttacagctaa cttaagaaat                                                   20


<210> 20546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20546
gtaaaactta cagctaactt                                                   20


<210> 20547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20547
acataaatct gtaaaactta                                                   20


<210> 20548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20548
ggtgaaatta tagactaatg                                                   20


<210> 20549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20549
gacttaaaaa ggtgaaatta                                                   20


<210> 20550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20550
atttatgctg tgacttaaaa                                                   20


<210> 20551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20551
aatttatgct gtgacttaaa                                                   20


<210> 20552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20552
aaaataaatt cttaattata                                                   20


<210> 20553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20553
tacaagttaa gtaatgatct                                                   20


<210> 20554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20554
attccagcac cctacaagtt                                                   20


<210> 20555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20555
ctttaattcc agcaccctac                                                   20


<210> 20556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20556
aaccaggtca tctttaattc                                                   20


<210> 20557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20557
aataaaggga aaccataacc                                                   20


<210> 20558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20558
gaataaaggg aaaccataac                                                   20


<210> 20559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20559
accaaatcca agagaataaa                                                   20


<210> 20560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20560
taccaaatcc aagagaataa                                                   20


<210> 20561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20561
ttaccaaatc caagagaata                                                   20


<210> 20562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20562
ctgaatatta ccaaatccaa                                                   20


<210> 20563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20563
agctgaatat taccaaatcc                                                   20


<210> 20564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20564
aaaaataagt aaataagagg                                                   20


<210> 20565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20565
taaaaaaata agtaaataag                                                   20


<210> 20566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20566
ttaaaaaaat aagtaaataa                                                   20


<210> 20567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20567
aattaaaaaa ataagtaaat                                                   20


<210> 20568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20568
tagcaaacaa ttaaaaaaat                                                   20


<210> 20569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20569
atgggaagct tcccattcaa                                                   20


<210> 20570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20570
agaaaattca atataatggg                                                   20


<210> 20571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20571
ataagaaaat tcaatataat                                                   20


<210> 20572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20572
aataagaaaa ttcaatataa                                                   20


<210> 20573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20573
ccattaggtg tttgatgaat                                                   20


<210> 20574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20574
agggaagtct ggttaccatt                                                   20


<210> 20575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20575
aagggaagtc tggttaccat                                                   20


<210> 20576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20576
ctaaggcaga aagggaagtc                                                   20


<210> 20577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20577
acactctaag gcagaaaggg                                                   20


<210> 20578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20578
aaaacactct aaggcagaaa                                                   20


<210> 20579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20579
aaaaacactc taaggcagaa                                                   20


<210> 20580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20580
caaaaacact ctaaggcaga                                                   20


<210> 20581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20581
acaacaaaaa cactctaagg                                                   20


<210> 20582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20582
acaacaacaa aaacactcta                                                   20


<210> 20583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20583
aacaacaaca aaaacactct                                                   20


<210> 20584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20584
tccagcctgt gcctcagagc                                                   20


<210> 20585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20585
gcactccagc ctgtgcctca                                                   20


<210> 20586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20586
ctgcactcca gcctgtgcct                                                   20


<210> 20587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20587
aagatggtgg cactgcactc                                                   20


<210> 20588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20588
gttgcagtga gccaagatgg                                                   20


<210> 20589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20589
gaggttgcag tgagccaaga                                                   20


<210> 20590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20590
ggtggaggtt gcagtgagcc                                                   20


<210> 20591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20591
caggaggtgg aggttgcagt                                                   20


<210> 20592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20592
aacccaggag gtggaggttg                                                   20


<210> 20593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20593
tacttgaacc caggaggtgg                                                   20


<210> 20594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20594
ttacttgaac ccaggaggtg                                                   20


<210> 20595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20595
aattacttga acccaggagg                                                   20


<210> 20596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20596
gagaattact tgaacccagg                                                   20


<210> 20597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20597
tgagaattac ttgaacccag                                                   20


<210> 20598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20598
catgagaatt acttgaaccc                                                   20


<210> 20599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20599
acatgagaat tacttgaacc                                                   20


<210> 20600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20600
tacttgggag gctgagacat                                                   20


<210> 20601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20601
tcccagctac ttgggaggct                                                   20


<210> 20602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20602
tgtaatccca gctacttggg                                                   20


<210> 20603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20603
ctgtaatccc agctacttgg                                                   20


<210> 20604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20604
acctgtaatc ccagctactt                                                   20


<210> 20605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20605
cacctgtaat cccagctact                                                   20


<210> 20606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20606
gtggcatgca cctgtaatcc                                                   20


<210> 20607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20607
caaaaattag cctgatgtgg                                                   20


<210> 20608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20608
atacaaaaat tagcctgatg                                                   20


<210> 20609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20609
tctactaaaa atacaaaaat                                                   20


<210> 20610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20610
caaaaccaga ccagccaaca                                                   20


<210> 20611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20611
ccaggagttc aaaaccagac                                                   20


<210> 20612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20612
tgaggccagg agttcaaaac                                                   20


<210> 20613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20613
ggcagatcac ttgaggccag                                                   20


<210> 20614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20614
ctggcagatc acttgaggcc                                                   20


<210> 20615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20615
gctggcagat cacttgaggc                                                   20


<210> 20616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20616
caaggctggc agatcacttg                                                   20


<210> 20617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20617
ccaaggctgg cagatcactt                                                   20


<210> 20618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20618
ctttgggagg ccaaggctgg                                                   20


<210> 20619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20619
gcactttggg aggccaaggc                                                   20


<210> 20620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20620
cccagcactt tgggaggcca                                                   20


<210> 20621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20621
tcccagcact ttgggaggcc                                                   20


<210> 20622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20622
tgtaatccca gcactttggg                                                   20


<210> 20623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20623
ctgtaatccc agcactttgg                                                   20


<210> 20624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20624
gcctgtaatc ccagcacttt                                                   20


<210> 20625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20625
cgcctgtaat cccagcactt                                                   20


<210> 20626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20626
gtggctcacg cctgtaatcc                                                   20


<210> 20627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20627
tctaaggtgg ccggatatgg                                                   20


<210> 20628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20628
cactctaagg tggccggata                                                   20


<210> 20629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 20629
ttaaaacact ctaaggtggc                                                   20


<210> 20630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20630
tgaattaaaa cactctaagg                                                   20


<210> 20631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20631
agctgaatta aaacactcta                                                   20


<210> 20632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20632
aagctgaatt aaaacactct                                                   20


<210> 20633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20633
actgcatatt aaatagagga                                                   20


<210> 20634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20634
aaagactgca tattaaatag                                                   20


<210> 20635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20635
taaagactgc atattaaata                                                   20


<210> 20636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20636
cataaagact gcatattaaa                                                   20


<210> 20637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20637
atgaatatga aaattacata                                                   20


<210> 20638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20638
ctcatgcctt gccagtaggt                                                   20


<210> 20639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20639
ctctctcatg ccttgccagt                                                   20


<210> 20640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20640
tctctctcat gccttgccag                                                   20


<210> 20641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20641
ctgtctctct catgccttgc                                                   20


<210> 20642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20642
tttctcttga cattgacatg                                                   20


<210> 20643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20643
taatgaacag taaaggatct                                                   20


<210> 20644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20644
ttaatgaaca gtaaaggatc                                                   20


<210> 20645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20645
tccccattaa tgaacagtaa                                                   20


<210> 20646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20646
gtccccatta atgaacagta                                                   20


<210> 20647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20647
tttcagtccc cattaatgaa                                                   20


<210> 20648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20648
tcttggcatg ctgtaatttt                                                   20


<210> 20649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20649
agcttcttct gtcaagttct                                                   20


<210> 20650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20650
tttctccagc ttcttctgtc                                                   20


<210> 20651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20651
ttttctcctc agtttttctc                                                   20


<210> 20652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20652
caaagttgga gttttctcct                                                   20


<210> 20653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20653
tgattttctc ttcaaagttg                                                   20


<210> 20654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20654
tttgattttc tcttcaaagt                                                   20


<210> 20655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20655
ttactttgat tttctcttca                                                   20


<210> 20656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20656
gacaaccagg atatcattag                                                   20


<210> 20657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20657
tgacaaccag gatatcatta                                                   20


<210> 20658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20658
ttgacaacca ggatatcatt                                                   20


<210> 20659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20659
attgacaacc aggatatcat                                                   20


<210> 20660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20660
tcttcatcat attgacaacc                                                   20


<210> 20661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20661
ttcttcatca tattgacaac                                                   20


<210> 20662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20662
attaattcat aatctcctat                                                   20


<210> 20663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20663
ggaaaacaaa acacccacgc                                                   20


<210> 20664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20664
acaaggccta aataagctat                                                   20


<210> 20665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20665
cacaaggcct aaataagcta                                                   20


<210> 20666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20666
attttgcaca aggcctaaat                                                   20


<210> 20667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20667
aaagggatac attttgcaca                                                   20


<210> 20668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20668
taaagggata cattttgcac                                                   20


<210> 20669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20669
ccttccacct aggttttaaa                                                   20


<210> 20670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20670
tccttccacc taggttttaa                                                   20


<210> 20671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20671
ttccttccac ctaggtttta                                                   20


<210> 20672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20672
ttacagaatt ccttccacct                                                   20


<210> 20673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20673
cttacagaat tccttccacc                                                   20


<210> 20674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20674
aaaaaaacta gcctgactta                                                   20


<210> 20675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20675
attgtaacac agaaaaaaac                                                   20


<210> 20676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20676
cctcaatgta gattgtaaca                                                   20


<210> 20677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20677
tatgtaatac agcctcaatg                                                   20


<210> 20678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20678
gtctttatta ctatgtaata                                                   20


<210> 20679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20679
atctgacacc agaagtgaag                                                   20


<210> 20680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20680
atgatctgac accagaagtg                                                   20


<210> 20681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20681
caaagatgat ctgacaccag                                                   20


<210> 20682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20682
gaacaaagat gatctgacac                                                   20


<210> 20683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20683
caaaagaaag gacttgaaca                                                   20


<210> 20684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20684
cttacccaag gacaaaagaa                                                   20


<210> 20685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20685
acttacccaa ggacaaaaga                                                   20


<210> 20686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20686
agaaacttac ccaaggacaa                                                   20


<210> 20687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20687
agaattaaga aacttaccca                                                   20


<210> 20688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20688
aagaattaag aaacttaccc                                                   20


<210> 20689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20689
gtggttttac ttaaagaatt                                                   20


<210> 20690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20690
tgatgaggtg gttttactta                                                   20


<210> 20691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20691
ctactcttat aatgatgagg                                                   20


<210> 20692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20692
tgactactct tataatgatg                                                   20


<210> 20693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20693
gtgactactc ttataatgat                                                   20


<210> 20694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20694
cttctcagca aacacaaatg                                                   20


<210> 20695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20695
attacctcaa tttatcttct                                                   20


<210> 20696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20696
catgtgccag atattatgct                                                   20


<210> 20697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20697
aatgaagact taccatgtgc                                                   20


<210> 20698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20698
atagtaacta aaatttaatg                                                   20


<210> 20699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20699
tttaatagca ccaacagtaa                                                   20


<210> 20700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20700
aggaagttta atagcaccaa                                                   20


<210> 20701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20701
catcttatca ggaagtttaa                                                   20


<210> 20702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20702
ttaactctca tcttatcagg                                                   20


<210> 20703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20703
tcattaactc tcatcttatc                                                   20


<210> 20704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20704
ttcattaact ctcatcttat                                                   20


<210> 20705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20705
tacaaatttg agcaactatg                                                   20


<210> 20706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20706
attacaaatt tgagcaacta                                                   20


<210> 20707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20707
aaatatataa ttacaaattt                                                   20


<210> 20708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20708
gagttcaagt tataaaaagg                                                   20


<210> 20709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20709
aatgagttca agttataaaa                                                   20


<210> 20710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20710
taatgagttc aagttataaa                                                   20


<210> 20711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20711
caaaagtcat taatgagttc                                                   20


<210> 20712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20712
ttagaacaaa agtcattaat                                                   20


<210> 20713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20713
acatactact attagaacaa                                                   20


<210> 20714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20714
atcataaaac atactactat                                                   20


<210> 20715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20715
ctaatgattt catgtgaaat                                                   20


<210> 20716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20716
caactattca tcatcctcat                                                   20


<210> 20717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20717
aataaccaac cctattttac                                                   20


<210> 20718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20718
aataatttga tcaaagctta                                                   20


<210> 20719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20719
taacttcaat aatttgatca                                                   20


<210> 20720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20720
caagtaacag gataccagca                                                   20


<210> 20721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20721
caaaccaagt aacaggatac                                                   20


<210> 20722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20722
attgtttcaa accaagtaac                                                   20


<210> 20723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20723
aattgtttca aaccaagtaa                                                   20


<210> 20724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20724
tggataaatt gtttcaaacc                                                   20


<210> 20725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20725
aaattagccc ctagaaagga                                                   20


<210> 20726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20726
gaataaatta gcccctagaa                                                   20


<210> 20727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20727
tgaataaatt agcccctaga                                                   20


<210> 20728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20728
aaaatgaata aattagcccc                                                   20


<210> 20729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20729
cttgatgaaa atgaataaat                                                   20


<210> 20730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20730
tcctctccct cccttgaaag                                                   20


<210> 20731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20731
cactcctctc cctcccttga                                                   20


<210> 20732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20732
gtgcagcaca ctgaatggca                                                   20


<210> 20733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20733
agtgcagcac actgaatggc                                                   20


<210> 20734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20734
ccctagtgca gcacactgaa                                                   20


<210> 20735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20735
agtgaaactg gaccctagtg                                                   20


<210> 20736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20736
gcaagagtga aactggaccc                                                   20


<210> 20737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20737
atatgaggca agagtgaaac                                                   20


<210> 20738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20738
cagtgctcca tatgaggcaa                                                   20


<210> 20739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20739
ttcagtgctc catatgaggc                                                   20


<210> 20740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20740
ttctttcagt gctccatatg                                                   20


<210> 20741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20741
gttctttcag tgctccatat                                                   20


<210> 20742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20742
tctaatcata ctggttcttt                                                   20


<210> 20743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20743
atcaattgtt ctaatcatac                                                   20


<210> 20744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20744
gtcccctttt cctatgtttg                                                   20


<210> 20745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20745
gatactgaga gtctctcaaa                                                   20


<210> 20746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20746
agcctggcta gagatactga                                                   20


<210> 20747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20747
tcagcctggc tagagatact                                                   20


<210> 20748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20748
tttgccagtc agcctggcta                                                   20


<210> 20749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20749
cctttgccag tcagcctggc                                                   20


<210> 20750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20750
aagacctttg ccagtcagcc                                                   20


<210> 20751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20751
agggcaagac ctttgccagt                                                   20


<210> 20752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20752
tgacagggca agacctttgc                                                   20


<210> 20753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20753
tggactgact ttgacagggc                                                   20


<210> 20754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20754
tttatggact gactttgaca                                                   20


<210> 20755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20755
atttatggac tgactttgac                                                   20


<210> 20756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20756
gatttatgga ctgactttga                                                   20


<210> 20757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20757
aaaacagcca ccaagattta                                                   20


<210> 20758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20758
aaggacacaa aacagccacc                                                   20


<210> 20759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20759
atgtcacaaa ggacacaaaa                                                   20


<210> 20760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20760
catccgacac aatgtcacaa                                                   20


<210> 20761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20761
ccatccgaca caatgtcaca                                                   20


<210> 20762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20762
ttggaagaat agccacctgt                                                   20


<210> 20763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20763
gtgtctgtgc attggaagaa                                                   20


<210> 20764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20764
cattggtgtc tgtgcattgg                                                   20


<210> 20765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20765
ttgcattggt gtctgtgcat                                                   20


<210> 20766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20766
gtgttccttg tgctttgcat                                                   20


<210> 20767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 20767
ttctttaggg tcagtaactg                                                   20


<210> 20768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20768
aatctctatt tctttagggt                                                   20


<210> 20769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20769
tataaatctc tatttcttta                                                   20


<210> 20770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20770
ttataaatct ctatttcttt                                                   20


<210> 20771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20771
tttataaatc tctatttctt                                                   20


<210> 20772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20772
attattttga attctttttt                                                   20


<210> 20773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20773
aattattttg aattcttttt                                                   20


<210> 20774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20774
gtactttgct aaacttcatt                                                   20


<210> 20775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20775
ggtactttgc taaacttcat                                                   20


<210> 20776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20776
agttgtctat ctctgttctc                                                   20


<210> 20777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20777
atcatcttcc tgattttgtt                                                   20


<210> 20778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20778
actttttgtg tgtgtgtgta                                                   20


<210> 20779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20779
tattgtattc ttcaattcca                                                   20


<210> 20780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20780
attattgtat tcttcaattc                                                   20


<210> 20781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20781
gaatcctcta gggagttttt                                                   20


<210> 20782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20782
ctgctattga atcctctagg                                                   20


<210> 20783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20783
gtctgctatt gaatcctcta                                                   20


<210> 20784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20784
agtctgctat tgaatcctct                                                   20


<210> 20785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20785
aagtctgcta ttgaatcctc                                                   20


<210> 20786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20786
attctttctc cagtttgatc                                                   20


<210> 20787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20787
tggtttgttg attctttctc                                                   20


<210> 20788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20788
tgatggggtt gtttttttct                                                   20


<210> 20789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20789
cctttaccca gtttttgatg                                                   20


<210> 20790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20790
tcctttaccc agtttttgat                                                   20


<210> 20791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20791
atcctttacc cagtttttga                                                   20


<210> 20792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20792
gtctgttcat atcctttacc                                                   20


<210> 20793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20793
cataaatgtc ttcttttgag                                                   20


<210> 20794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20794
ctgcataaat gtcttctttt                                                   20


<210> 20795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20795
gcattttttc atgtgttttt                                                   20


<210> 20796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20796
ctctgatggc cagtgatgat                                                   20


<210> 20797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20797
atttgcattt ctctgatggc                                                   20


<210> 20798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20798
tttgatttgc atttctctga                                                   20


<210> 20799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 20799
tatgagatgg tatctcattg                                                   20


<210> 20800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20800
ccattctaac tggtatgaga                                                   20


<210> 20801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20801
atcaccattc taactggtat                                                   20


<210> 20802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20802
ttaatgatca ccattctaac                                                   20


<210> 20803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20803
ctatttctcc acatcctctc                                                   20


<210> 20804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20804
cagtcccacc aacagtgtaa                                                   20


<210> 20805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20805
ctagtttaca gtcccaccaa                                                   20


<210> 20806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20806
acagtggttg aactagttta                                                   20


<210> 20807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20807
gacttccaca gtggttgaac                                                   20


<210> 20808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20808
cgccacacgg acttccacag                                                   20


<210> 20809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20809
aatcgccaca cggacttcca                                                   20


<210> 20810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 20810
atccttgagg aatcgccaca                                                   20


<210> 20811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20811
tttctagttc tagatccttg                                                   20


<210> 20812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20812
atttctagtt ctagatcctt                                                   20


<210> 20813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20813
tcaaatggta tttctagttc                                                   20


<210> 20814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20814
gctgggtcaa atggtatttc                                                   20


<210> 20815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20815
catgggatgg ctgggtcaaa                                                   20


<210> 20816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20816
tacccagtca tgggatggct                                                   20


<210> 20817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20817
atacccagtc atgggatggc                                                   20


<210> 20818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20818
gtatataccc agtcatggga                                                   20


<210> 20819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20819
ttgggtatat acccagtcat                                                   20


<210> 20820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20820
tttgggtata tacccagtca                                                   20


<210> 20821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20821
taatcctttg ggtatatacc                                                   20


<210> 20822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20822
agcatgattt ataatccttt                                                   20


<210> 20823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20823
cagcatgatt tataatcctt                                                   20


<210> 20824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20824
gtgtgcatgc gtctttatag                                                   20


<210> 20825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20825
tacgtgtgca tgcgtcttta                                                   20


<210> 20826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20826
caagtctttg ctattgtgaa                                                   20


<210> 20827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20827
tggacatttg gcttggttcc                                                   20


<210> 20828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20828
tcattgttgg acatttggct                                                   20


<210> 20829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20829
gtctatcatt gttggacatt                                                   20


<210> 20830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20830
ttaatccagt ctatcattgt                                                   20


<210> 20831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20831
tgtgccatat tttcttaatc                                                   20


<210> 20832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20832
tatggctgca tagtattcca                                                   20


<210> 20833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20833
catccttttt tatggctgca                                                   20


<210> 20834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20834
cttgagctca tcctttttta                                                   20


<210> 20835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20835
catgtccctg caaaggactt                                                   20


<210> 20836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20836
cttcatgcat gtccctgcaa                                                   20


<210> 20837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20837
gcttcatgca tgtccctgca                                                   20


<210> 20838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20838
ttgctgagaa tgatggtttc                                                   20


<210> 20839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20839
cgatagtttg ctgagaatga                                                   20


<210> 20840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20840
tttccttgcg atagtttgct                                                   20


<210> 20841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20841
tttggttttt ttccttgcga                                                   20


<210> 20842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20842
gagtgagaaa gtgcagtgtt                                                   20


<210> 20843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20843
cacctatgag tgagaaagtg                                                   20


<210> 20844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20844
attcccacct atgagtgaga                                                   20


<210> 20845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20845
ttcaattccc acctatgagt                                                   20


<210> 20846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20846
attgttcaat tcccacctat                                                   20


<210> 20847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20847
caacaggccc tggtgtgtga                                                   20


<210> 20848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20848
ccccacccca caacaggccc                                                   20


<210> 20849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20849
tcctcccccc accccacaac                                                   20


<210> 20850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20850
ctcctccccc caccccacaa                                                   20


<210> 20851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20851
taggtatatc tcctaatgtt                                                   20


<210> 20852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20852
ttaggtatat ctcctaatgt                                                   20


<210> 20853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20853
ttaactcatc atttaacatt                                                   20


<210> 20854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20854
attaactcat catttaacat                                                   20


<210> 20855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20855
tatgtataca tgtgccatgt                                                   20


<210> 20856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20856
catgtgcaca acgtgcaggt                                                   20


<210> 20857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20857
ggtacatgtg cacaacgtgc                                                   20


<210> 20858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20858
gggtacatgt gcacaacgtg                                                   20


<210> 20859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20859
ttattatact ttaagtttta                                                   20


<210> 20860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20860
tttattatac tttaagtttt                                                   20


<210> 20861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20861
ttttattata ctttaagttt                                                   20


<210> 20862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20862
tttatttttt attatacttt                                                   20


<210> 20863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20863
ttttggtgtc catcttttga                                                   20


<210> 20864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20864
tttttggtgt ccatcttttg                                                   20


<210> 20865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20865
ttttttggtg tccatctttt                                                   20


<210> 20866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20866
tctacctttt tttttttttt                                                   20


<210> 20867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20867
tttcttcttg ctccactgac                                                   20


<210> 20868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20868
ccccaaattt gaacatattt                                                   20


<210> 20869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20869
ttctttgagt ttcctgaatt                                                   20


<210> 20870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20870
tgtcctattt gggattcttt                                                   20


<210> 20871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20871
tctttagatt tgtcctattt                                                   20


<210> 20872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20872
ttctttagat ttgtcctatt                                                   20


<210> 20873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20873
atgcccagcc gagacttctt                                                   20


<210> 20874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20874
gtgagccacc atgcccagcc                                                   20


<210> 20875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20875
caggtgtgag ccaccatgcc                                                   20


<210> 20876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20876
agtgctggga ttacaggtgt                                                   20


<210> 20877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20877
cctcaaagtg ctgggattac                                                   20


<210> 20878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20878
ccctcaaagt gctgggatta                                                   20


<210> 20879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20879
gctcagcccc tcaaagtgct                                                   20


<210> 20880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20880
cgctcagccc ctcaaagtgc                                                   20


<210> 20881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20881
cactcccgct cagcccctca                                                   20


<210> 20882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20882
tcaggtgatc cactcccgct                                                   20


<210> 20883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20883
ggtcttgaac tcctgacctc                                                   20


<210> 20884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20884
tggtcttgaa ctcctgacct                                                   20


<210> 20885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20885
ttttgccatg ttggccaggc                                                   20


<210> 20886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20886
gtggttttgc catgttggcc                                                   20


<210> 20887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20887
tgtggttttg ccatgttggc                                                   20


<210> 20888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20888
gagatgtggt tttgccatgt                                                   20


<210> 20889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20889
tgtaattttt ggtagagatg                                                   20


<210> 20890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20890
gatttttgta atttttggta                                                   20


<210> 20891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20891
ctgatttttg taatttttgg                                                   20


<210> 20892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20892
cagctgattt ttgtaatttt                                                   20


<210> 20893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20893
taggcaccca ccaccacacc                                                   20


<210> 20894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20894
tcccgagtag ctgggattat                                                   20


<210> 20895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20895
ctcccgagta gctgggatta                                                   20


<210> 20896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20896
cctcagcctc ccgagtagct                                                   20


<210> 20897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20897
gcctcagcct cccgagtagc                                                   20


<210> 20898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20898
ctctgcctca gcctcccgag                                                   20


<210> 20899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20899
tctctctgcc tcagcctccc                                                   20


<210> 20900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20900
tcaagcaatt ctctctgcct                                                   20


<210> 20901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20901
aacttccacc tcgtgggttc                                                   20


<210> 20902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20902
cactgcaact tccacctcgt                                                   20


<210> 20903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20903
tcactgcaac ttccacctcg                                                   20


<210> 20904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20904
ggagtgcagt agcatgatct                                                   20


<210> 20905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20905
ttgcccaggc tggagtgcag                                                   20


<210> 20906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20906
gtgttgccca ggctggagtg                                                   20


<210> 20907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20907
tcaccgtgtt gcccaggctg                                                   20


<210> 20908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20908
tttcaccgtg ttgcccaggc                                                   20


<210> 20909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20909
agagtttcac cgtgttgccc                                                   20


<210> 20910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20910
tagagtttca ccgtgttgcc                                                   20


<210> 20911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20911
tttctttttt ttccgagata                                                   20


<210> 20912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20912
tctttctttt ttttccgaga                                                   20


<210> 20913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20913
actttctttc ttttttttcc                                                   20


<210> 20914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20914
atgatattat gtctctagtg                                                   20


<210> 20915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20915
tgatgatatt atgtctctag                                                   20


<210> 20916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20916
atttgatgat attatgtctc                                                   20


<210> 20917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20917
tcaaacttcc ctttcacttt                                                   20


<210> 20918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20918
ctcttttgga catgacaatt                                                   20


<210> 20919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20919
tcatcttaag agagctcttt                                                   20


<210> 20920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20920
atctgctgtt catcttaaga                                                   20


<210> 20921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20921
aaatctgctg ttcatcttaa                                                   20


<210> 20922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20922
agaaatctgc tgttcatctt                                                   20


<210> 20923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20923
gctcttttaa agtttccact                                                   20


<210> 20924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20924
tcactttatt tgctctttta                                                   20


<210> 20925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20925
ggtcagcagt ttttttcttt                                                   20


<210> 20926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20926
ggtatattat tcttggtcag                                                   20


<210> 20927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20927
ccaggtatat tattcttggt                                                   20


<210> 20928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20928
ttttccaggt atattattct                                                   20


<210> 20929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20929
ttttaaagga cagtttttcc                                                   20


<210> 20930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20930
attttaaagg acagtttttc                                                   20


<210> 20931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20931
ccttccttaa ttttaaagga                                                   20


<210> 20932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20932
ttatccttcc ttaattttaa                                                   20


<210> 20933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20933
tttatccttc cttaatttta                                                   20


<210> 20934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20934
cagcatttgc ttgtatgaga                                                   20


<210> 20935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20935
ccctcagcat ttgcttgtat                                                   20


<210> 20936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20936
ctagtggtga tgaactccct                                                   20


<210> 20937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20937
ttcctataag ataaatctag                                                   20


<210> 20938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20938
catttcctat aagataaatc                                                   20


<210> 20939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20939
ctcactttag catttcctat                                                   20


<210> 20940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20940
tcaacttgaa gaactcactt                                                   20


<210> 20941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20941
catgctttcg tttcaacttg                                                   20


<210> 20942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20942
atgtatttac ctttactagt                                                   20


<210> 20943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20943
gtccatgtat ttacctttac                                                   20


<210> 20944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20944
ataatactat tagagtatta                                                   20


<210> 20945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20945
tgatttatat aatactatta                                                   20


<210> 20946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20946
aatgatttat ataatactat                                                   20


<210> 20947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20947
ttgacattta acttttatat                                                   20


<210> 20948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20948
caaacacatt tttgtaattt                                                   20


<210> 20949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20949
atcttataat agtctacttt                                                   20


<210> 20950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20950
caatcacaaa tatcttataa                                                   20


<210> 20951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20951
ttttccttgt ggttatcatg                                                   20


<210> 20952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20952
attttccttg tggttatcat                                                   20


<210> 20953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20953
ttttacgtgg attttccttg                                                   20


<210> 20954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20954
tttatttctg tatttttacg                                                   20


<210> 20955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20955
taactgtctt cttttgtgat                                                   20


<210> 20956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20956
tatttgaaat aatcattggt                                                   20


<210> 20957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20957
gtatttgaaa taatcattgg                                                   20


<210> 20958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20958
tttgtatttg aaataatcat                                                   20


<210> 20959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20959
ttgtaggtct tttgattggg                                                   20


<210> 20960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20960
ccattgtagg tcttttgatt                                                   20


<210> 20961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20961
gccattgtag gtcttttgat                                                   20


<210> 20962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20962
taaatctatg cagccattgt                                                   20


<210> 20963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20963
ataaatctat gcagccattg                                                   20


<210> 20964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20964
cttgttttca taaatctatg                                                   20


<210> 20965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20965
atctggagac agcatataac                                                   20


<210> 20966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20966
ctgaaacgag tatctggaga                                                   20


<210> 20967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20967
aaatctgaaa cgagtatctg                                                   20


<210> 20968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20968
ttaaatctga aacgagtatc                                                   20


<210> 20969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20969
tgttttctta aatctgaaac                                                   20


<210> 20970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20970
atagccccat tgctctcttt                                                   20


<210> 20971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20971
gatactgaag gacgactgta                                                   20


<210> 20972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20972
catgaccctg tagatactga                                                   20


<210> 20973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20973
ccatgaccct gtagatactg                                                   20


<210> 20974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20974
gttctgaaac catgaccctg                                                   20


<210> 20975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20975
ctcaattttg gtatcccttg                                                   20


<210> 20976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20976
cctcaatttt ggtatccctt                                                   20


<210> 20977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20977
tcctcaattt tggtatccct                                                   20


<210> 20978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20978
gacttaagca tcctcaattt                                                   20


<210> 20979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20979
caagactgac tgtgggactt                                                   20


<210> 20980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20980
ggtcctgcaa gactgactgt                                                   20


<210> 20981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20981
aggtcctgca agactgactg                                                   20


<210> 20982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 20982
tttttatcca caggtcctgc                                                   20


<210> 20983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20983
ggtcaaattt ttttatccac                                                   20


<210> 20984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20984
gggtcaaatt tttttatcca                                                   20


<210> 20985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20985
gtgaaatcca cagatacaga                                                   20


<210> 20986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20986
tgtgaaatcc acagatacag                                                   20


<210> 20987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 20987
atgtgaaatc cacagataca                                                   20


<210> 20988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20988
gaatgtgaaa tccacagata                                                   20


<210> 20989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20989
ttcatggaat gtgaaatcca                                                   20


<210> 20990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20990
gattgaaaac actgtattca                                                   20


<210> 20991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20991
gggttttaca tctgtagatt                                                   20


<210> 20992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 20992
gtctgtgggt tttacatctg                                                   20


<210> 20993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20993
agggtgtcct ctgtgtctgt                                                   20


<210> 20994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20994
cagggtgtcc tctgtgtctg                                                   20


<210> 20995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 20995
ttttggctga tataattaca                                                   20


<210> 20996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 20996
attttggctg atataattac                                                   20


<210> 20997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20997
tattttggct gatataatta                                                   20


<210> 20998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 20998
tttttattta aaatctattt                                                   20


<210> 20999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 20999
acctactttg tctcttgtga                                                   20


<210> 21000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21000
gtatttacat gctttgatga                                                   20


<210> 21001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21001
ttgctgcatg tttatccctt                                                   20


<210> 21002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21002
attgatgtat cctactgtta                                                   20


<210> 21003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21003
tctgttcatt attgcaagtc                                                   20


<210> 21004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 21004
ttctgttcat tattgcaagt                                                   20


<210> 21005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21005
gctgttctgt tcattattgc                                                   20


<210> 21006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21006
ttgtttatag attccatatc                                                   20


<210> 21007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21007
tcaaatccac agtttgttta                                                   20


<210> 21008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21008
tatagcgttg ttcaaatcca                                                   20


<210> 21009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21009
tttgtgatcc atttggtcta                                                   20


<210> 21010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21010
ctgtgtgttt gtgatccatt                                                   20


<210> 21011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21011
tatattaaga tgctgttggg                                                   20


<210> 21012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21012
tggtatatta agatgctgtt                                                   20


<210> 21013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21013
atggtatatt aagatgctgt                                                   20


<210> 21014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21014
acttgaaaag atggtatatt                                                   20


<210> 21015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21015
tctgtgcgca cttgaaaaga                                                   20


<210> 21016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21016
atattctgtg cgcacttgaa                                                   20


<210> 21017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21017
cctgatatgt gatctatcct                                                   20


<210> 21018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21018
gtatgatttc aacttcttaa                                                   20


<210> 21019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21019
ttgtggtcat aaaagatatc                                                   20


<210> 21020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21020
tccttccatt gtggtcataa                                                   20


<210> 21021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21021
cttccagttt ccttccattg                                                   20


<210> 21022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21022
ttccttctat tactgacttc                                                   20


<210> 21023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21023
ccacatattt gtgaattttt                                                   20


<210> 21024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21024
gacccattgc tttttcaaga                                                   20


<210> 21025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21025
ttgacccatt gctttttcaa                                                   20


<210> 21026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21026
ctttgaccca ttgctttttc                                                   20


<210> 21027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21027
ctttcatttt tgtttgtttc                                                   20


<210> 21028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21028
ttgctgcatc tcataaattt                                                   20


<210> 21029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21029
atgtagacat gtatctcaat                                                   20


<210> 21030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21030
agatatttct ttttataatg                                                   20


<210> 21031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21031
taaatctata ttgtttatat                                                   20


<210> 21032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21032
tttgttcttt ttctagttcc                                                   20


<210> 21033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21033
ggcttagttt gttctttttc                                                   20


<210> 21034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21034
ccttttgctg atgttgggct                                                   20


<210> 21035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21035
tccttccttt tgctgatgtt                                                   20


<210> 21036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21036
ttccttcctt ttgctgatgt                                                   20


<210> 21037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21037
tattctctat ttcacttact                                                   20


<210> 21038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21038
ctttcgaaaa aaccaattct                                                   20


<210> 21039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21039
tttcttagtt atgcttgcta                                                   20


<210> 21040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21040
ttttcttagt tatgcttgct                                                   20


<210> 21041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21041
gagtcctcta tcttttttct                                                   20


<210> 21042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21042
atttctggtt ttacatattt                                                   20


<210> 21043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21043
aaattctcct ctttcatttc                                                   20


<210> 21044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21044
ccttcttatt cccataaaat                                                   20


<210> 21045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21045
tggtgtataa ttgttcatgg                                                   20


<210> 21046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21046
tgttggtgta taattgttca                                                   20


<210> 21047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21047
ttctaagtta tccaatttgt                                                   20


<210> 21048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21048
ggaatttacc tattccttct                                                   20


<210> 21049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21049
cttggtaggt tgtatatttt                                                   20


<210> 21050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21050
cctcatgatt cagtcttggt                                                   20


<210> 21051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21051
tcctcatgat tcagtcttgg                                                   20


<210> 21052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21052
atttcctcat gattcagtct                                                   20


<210> 21053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21053
tattctattt cctcatgatt                                                   20


<210> 21054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21054
attggttcaa tttgtctatt                                                   20


<210> 21055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21055
attattatta ttattattat                                                   20


<210> 21056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21056
cctgtacatt tcttttttgg                                                   20


<210> 21057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21057
gtcctgtaca tttctttttt                                                   20


<210> 21058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21058
ggtcctgtac atttcttttt                                                   20


<210> 21059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21059
acttctccag agaagccgtc                                                   20


<210> 21060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21060
ttggttggac ttctccagag                                                   20


<210> 21061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21061
tgtttggttg gacttctcca                                                   20


<210> 21062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21062
aatgtttggt tggacttctc                                                   20


<210> 21063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21063
ttcttcttta aatgtttggt                                                   20


<210> 21064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21064
ttgtttcttc tttaaatgtt                                                   20


<210> 21065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21065
aagttttaag agagtttgag                                                   20


<210> 21066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21066
tcaaagtttt aagagagttt                                                   20


<210> 21067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21067
tcctcttcaa agttttaaga                                                   20


<210> 21068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21068
tttcctcttc aaagttttaa                                                   20


<210> 21069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21069
tctttcctct tcaaagtttt                                                   20


<210> 21070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21070
gaagtgttct ttcctcttca                                                   20


<210> 21071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21071
gccccataaa atgactttcg                                                   20


<210> 21072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21072
ctttgatatg agaataattc                                                   20


<210> 21073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21073
tctttgtctg gctttgatat                                                   20


<210> 21074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21074
tttcttacag tgtctttgtc                                                   20


<210> 21075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21075
gctgtaattt tcttttctta                                                   20


<210> 21076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21076
gctgaagtca cttccttcaa                                                   20


<210> 21077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21077
cctattccac aatgttgctg                                                   20


<210> 21078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21078
tacgtccatg agagaaaaaa                                                   20


<210> 21079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21079
tttacttggt acgtccatga                                                   20


<210> 21080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21080
tgtttacttg gtacgtccat                                                   20


<210> 21081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21081
tgtgtatgta gatgtttact                                                   20


<210> 21082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21082
agaactgatc catgtgtatg                                                   20


<210> 21083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21083
ggattctggg tttctctgga                                                   20


<210> 21084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21084
ctggattctg ggtttctctg                                                   20


<210> 21085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21085
tactggattc tgggtttctc                                                   20


<210> 21086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21086
gagtttttct actggattct                                                   20


<210> 21087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21087
tgagtttttc tactggattc                                                   20


<210> 21088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21088
gtgtgcatga gtttttctac                                                   20


<210> 21089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21089
ttctgtcctc tggtgtgcat                                                   20


<210> 21090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21090
tatgggtatt ttctgtcctc                                                   20


<210> 21091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21091
ttttctaccc attttgatat                                                   20


<210> 21092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21092
tttttctacc cattttgata                                                   20


<210> 21093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21093
tcagggtggg gttagtgcat                                                   20


<210> 21094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21094
cactgtgctc agggtggggt                                                   20


<210> 21095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21095
aaggcactgt gctcagggtg                                                   20


<210> 21096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21096
taaggcactg tgctcagggt                                                   20


<210> 21097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21097
gtaaggcact gtgctcaggg                                                   20


<210> 21098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21098
aatgtaaggc actgtgctca                                                   20


<210> 21099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21099
aaatgtaagg cactgtgctc                                                   20


<210> 21100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21100
caaatgtaag gcactgtgct                                                   20


<210> 21101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21101
tggttttctt cccaaatgta                                                   20


<210> 21102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21102
ttggttttct tcccaaatgt                                                   20


<210> 21103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21103
ttgggaagta gctgcaaatt                                                   20


<210> 21104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21104
gtttctcaac ccttgggaag                                                   20


<210> 21105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21105
atagtttctc aacccttggg                                                   20


<210> 21106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21106
gctatagttt ctcaaccctt                                                   20


<210> 21107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21107
tgctatagtt tctcaaccct                                                   20


<210> 21108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21108
tgggttctat atgtgtgcta                                                   20


<210> 21109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21109
ccttaaatta aaaaaaagtt                                                   20


<210> 21110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21110
tccttaaatt aaaaaaaagt                                                   20


<210> 21111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21111
catttcctta aattaaaaaa                                                   20


<210> 21112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21112
actctagaaa aagcattttc                                                   20


<210> 21113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21113
ctctctttac actctagaaa                                                   20


<210> 21114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21114
tctcttctct ctttacactc                                                   20


<210> 21115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21115
atgaagatga ttttataata                                                   20


<210> 21116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21116
ggaaaaccaa ggcaattatg                                                   20


<210> 21117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21117
ttctacaaaa tggaaaacca                                                   20


<210> 21118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21118
gttctacaaa atggaaaacc                                                   20


<210> 21119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21119
aaaagttggg ttctacaaaa                                                   20


<210> 21120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21120
tgtcagggcc tataaaagtt                                                   20


<210> 21121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21121
gtgtcagggc ctataaaagt                                                   20


<210> 21122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21122
ctctgtgtca gggcctataa                                                   20


<210> 21123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21123
aaaagccaag ctctgtgtca                                                   20


<210> 21124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21124
taaaagccaa gctctgtgtc                                                   20


<210> 21125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21125
ctaaaagcca agctctgtgt                                                   20


<210> 21126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21126
agcatggtga tctaaaagcc                                                   20


<210> 21127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21127
cctcaagcat ggtgatctaa                                                   20


<210> 21128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21128
tctctgccat tcctcaagca                                                   20


<210> 21129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21129
gcttatctct gccattcctc                                                   20


<210> 21130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21130
tacttgagag aaaactccaa                                                   20


<210> 21131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21131
ccatcgtttt ttgtacttga                                                   20


<210> 21132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21132
ccccatcgtt ttttgtactt                                                   20


<210> 21133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21133
agcttctgag agtgctcagg                                                   20


<210> 21134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21134
taaagcttct gagagtgctc                                                   20


<210> 21135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21135
ttaaagcttc tgagagtgct                                                   20


<210> 21136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21136
ccaggaatta aagcttctga                                                   20


<210> 21137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21137
tcccaggaat taaagcttct                                                   20


<210> 21138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21138
tggtctgatc ccaggaatta                                                   20


<210> 21139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21139
ttggaagatg gtctgatccc                                                   20


<210> 21140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21140
gttggaagat ggtctgatcc                                                   20


<210> 21141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21141
tccatgggga agttggaaga                                                   20


<210> 21142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21142
ggtttccatg gggaagttgg                                                   20


<210> 21143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21143
aatggtttcc atggggaagt                                                   20


<210> 21144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21144
gcctaatggt ttccatgggg                                                   20


<210> 21145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21145
gtagcctaat ggtttccatg                                                   20


<210> 21146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21146
tgtagcctaa tggtttccat                                                   20


<210> 21147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21147
gtgtagccta atggtttcca                                                   20


<210> 21148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21148
ctggaaaacg tgtagcctaa                                                   20


<210> 21149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21149
gggagcggct ggaaaacgtg                                                   20


<210> 21150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21150
ccagaaccac agggagcggc                                                   20


<210> 21151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 21151
gaggccagaa ccacagggag                                                   20


<210> 21152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21152
gaagaggcca gaaccacagg                                                   20


<210> 21153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21153
tggaagaggc cagaaccaca                                                   20


<210> 21154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21154
ctggaagagg ccagaaccac                                                   20


<210> 21155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21155
actggaagag gccagaacca                                                   20


<210> 21156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21156
ttccaagtac tggaagaggc                                                   20


<210> 21157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21157
agatttccaa gtactggaag                                                   20


<210> 21158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21158
tagatttcca agtactggaa                                                   20


<210> 21159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21159
tgtagatttc caagtactgg                                                   20


<210> 21160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21160
ctatgtagat ttccaagtac                                                   20


<210> 21161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21161
catttgctat gtagatttcc                                                   20


<210> 21162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21162
tttattcttc atttgctatg                                                   20


<210> 21163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21163
cctcttgttt aggctgaaga                                                   20


<210> 21164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21164
tcctcttgtt taggctgaag                                                   20


<210> 21165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21165
tattcctctt gtttaggctg                                                   20


<210> 21166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21166
gaatgttatt cctcttgttt                                                   20


<210> 21167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21167
ggaatgttat tcctcttgtt                                                   20


<210> 21168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21168
aagccaggga agaaggcgtg                                                   20


<210> 21169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21169
gaagccaggg aagaaggcgt                                                   20


<210> 21170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21170
ggaagccagg gaagaaggcg                                                   20


<210> 21171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21171
ctggaggaag ccagggaaga                                                   20


<210> 21172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21172
tctggaggaa gccagggaag                                                   20


<210> 21173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21173
gtctctggag gaagccaggg                                                   20


<210> 21174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21174
attgtctctg gaggaagcca                                                   20


<210> 21175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21175
gattgtctct ggaggaagcc                                                   20


<210> 21176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21176
ggattgtctc tggaggaagc                                                   20


<210> 21177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21177
gttgggattg tctctggagg                                                   20


<210> 21178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21178
agagttggga ttgtctctgg                                                   20


<210> 21179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21179
tagagttggg attgtctctg                                                   20


<210> 21180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21180
tgtagagttg ggattgtctc                                                   20


<210> 21181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21181
aaaagaaaga ttgtagagtt                                                   20


<210> 21182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21182
aaaaagaaag attgtagagt                                                   20


<210> 21183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21183
aaaaaaaaag aaagattgta                                                   20


<210> 21184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21184
aaaaaaaaaa agaaagattg                                                   20


<210> 21185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21185
aaaaaaaaaa aaaaaaaaga                                                   20


<210> 21186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21186
caaaaaaaaa aaaaaaaaaa                                                   20


<210> 21187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21187
gggcgacaga gcgagacagc                                                   20


<210> 21188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21188
gcctgggcga cagagcgaga                                                   20


<210> 21189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21189
tccagcctgg gcgacagagc                                                   20


<210> 21190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21190
gcactccagc ctgggcgaca                                                   20


<210> 21191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21191
ctgcactcca gcctgggcga                                                   20


<210> 21192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21192
gcgccactgc actccagcct                                                   20


<210> 21193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21193
tgcgccactg cactccagcc                                                   20


<210> 21194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21194
gagattgcgc cactgcactc                                                   20


<210> 21195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21195
ggcggagctt gcagtgagcc                                                   20


<210> 21196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21196
cgggaggcgg agcttgcagt                                                   20


<210> 21197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21197
aacccgggag gcggagcttg                                                   20


<210> 21198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21198
tggcatgaac ccgggaggcg                                                   20


<210> 21199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 21199
aatggcatga acccgggagg                                                   20


<210> 21200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21200
gagaatggca tgaacccggg                                                   20


<210> 21201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21201
ggagaatggc atgaacccgg                                                   20


<210> 21202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21202
caggagaatg gcatgaaccc                                                   20


<210> 21203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 21203
gcaggagaat ggcatgaacc                                                   20


<210> 21204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21204
gggaggctga ggcaggagaa                                                   20


<210> 21205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21205
tactcgggag gctgaggcag                                                   20


<210> 21206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21206
gctactcggg aggctgaggc                                                   20


<210> 21207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21207
agctactcgg gaggctgagg                                                   20


<210> 21208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21208
cccagctact cgggaggctg                                                   20


<210> 21209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21209
tcccagctac tcgggaggct                                                   20


<210> 21210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21210
tgtagtccca gctactcggg                                                   20


<210> 21211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21211
ctgtagtccc agctactcgg                                                   20


<210> 21212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21212
gcctgtagtc ccagctactc                                                   20


<210> 21213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 21213
cgcctgtagt cccagctact                                                   20


<210> 21214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21214
gtagcgggcg cctgtagtcc                                                   20


<210> 21215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21215
ggcgtggtag cgggcgcctg                                                   20


<210> 21216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21216
aattagccgg gcgtggtagc                                                   20


<210> 21217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 21217
aaattagccg ggcgtggtag                                                   20


<210> 21218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21218
aaaaaattag ccgggcgtgg                                                   20


<210> 21219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21219
tacaaaaaat tagccgggcg                                                   20


<210> 21220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21220
aaaaatacaa aaaattagcc                                                   20


<210> 21221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 21221
taaaaataca aaaaattagc                                                   20


<210> 21222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21222
ctactaaaaa tacaaaaaat                                                   20


<210> 21223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 21223
cgagaccatc ctggctaaca                                                   20


<210> 21224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21224
tcaggagatc gagaccatcc                                                   20


<210> 21225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21225
gatcacgagg tcaggagatc                                                   20


<210> 21226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21226
cgggcggatc acgaggtcag                                                   20


<210> 21227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21227
ggcgggcgga tcacgaggtc                                                   20


<210> 21228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21228
aggcgggcgg atcacgaggt                                                   20


<210> 21229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21229
gccgaggcgg gcggatcacg                                                   20


<210> 21230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21230
ggccgaggcg ggcggatcac                                                   20


<210> 21231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 21231
ctttgggagg ccgaggcggg                                                   20


<210> 21232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21232
gcactttggg aggccgaggc                                                   20


<210> 21233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 21233
agcactttgg gaggccgagg                                                   20


<210> 21234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21234
cccagcactt tgggaggccg                                                   20


<210> 21235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21235
tcccagcact ttgggaggcc                                                   20


<210> 21236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21236
tgtaatccca gcactttggg                                                   20


<210> 21237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21237
ctgtaatccc agcactttgg                                                   20


<210> 21238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21238
gcctgtaatc ccagcacttt                                                   20


<210> 21239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21239
cgcctgtaat cccagcactt                                                   20


<210> 21240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21240
gtggctcacg cctgtaatcc                                                   20


<210> 21241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21241
aagattgtgg ccgggcgcgg                                                   20


<210> 21242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 21242
agaaagattg tggccgggcg                                                   20


<210> 21243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21243
ttaaaagaaa gattgtggcc                                                   20


<210> 21244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 21244
tttaaaagaa agattgtggc                                                   20


<210> 21245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21245
atcttttaaa agaaagattg                                                   20


<210> 21246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21246
cttccacatc ttttaaaaga                                                   20


<210> 21247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21247
agaccttcca catcttttaa                                                   20


<210> 21248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21248
ccttcctgtt cttggtggta                                                   20


<210> 21249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21249
caccttcctg ttcttggtgg                                                   20


<210> 21250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21250
agccaccttc ctgttcttgg                                                   20


<210> 21251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21251
agaagccacc ttcctgttct                                                   20


<210> 21252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21252
tcaggagcaa gccagggaag                                                   20


<210> 21253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21253
atgtcaggag caagccaggg                                                   20


<210> 21254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21254
attatgtcag gagcaagcca                                                   20


<210> 21255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21255
aattatgtca ggagcaagcc                                                   20


<210> 21256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21256
aaattatgtc aggagcaagc                                                   20


<210> 21257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21257
gcataaatta tgtcaggagc                                                   20


<210> 21258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21258
aactgcataa attatgtcag                                                   20


<210> 21259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21259
gaaactgcat aaattatgtc                                                   20


<210> 21260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21260
agaaactgca taaattatgt                                                   20


<210> 21261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21261
agttcaagcc ttcctctaat                                                   20


<210> 21262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21262
attggattaa agtgtagttc                                                   20


<210> 21263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21263
agatctattg gattaaagtg                                                   20


<210> 21264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21264
ctgttagatc tattggatta                                                   20


<210> 21265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21265
taaatatctg ttagatctat                                                   20


<210> 21266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21266
actgttctat aaatatctgt                                                   20


<210> 21267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21267
aatatgtatt ttgttgctgt                                                   20


<210> 21268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21268
agtgtttcat gtgatttgag                                                   20


<210> 21269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21269
gagagtgttt catgtgattt                                                   20


<210> 21270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21270
aacatgtgat ctatcctgga                                                   20


<210> 21271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21271
ctaacatgtg atctatcctg                                                   20


<210> 21272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21272
gcctaacatg tgatctatcc                                                   20


<210> 21273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21273
atttgttaaa acttgtttgg                                                   20


<210> 21274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21274
taaatttgtt aaaacttgtt                                                   20


<210> 21275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21275
tagtttcatg tcatcatgaa                                                   20


<210> 21276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21276
aggttattct tattgacttc                                                   20


<210> 21277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21277
acgtaattat gagttgttca                                                   20


<210> 21278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21278
cacgtaatta tgagttgttc                                                   20


<210> 21279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21279
tttaatttcc acgtaattat                                                   20


<210> 21280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21280
ttgacccatt gcctgttcag                                                   20


<210> 21281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21281
ctttgaccca ttgcctgttc                                                   20


<210> 21282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21282
tctttgaccc attgcctgtt                                                   20


<210> 21283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21283
tactataaat ttttctctca                                                   20


<210> 21284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21284
ttactataaa tttttctctc                                                   20


<210> 21285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21285
attactataa atttttctct                                                   20


<210> 21286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21286
tttccttctt tctttaatgt                                                   20


<210> 21287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21287
ttttccttct ttctttaatg                                                   20


<210> 21288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21288
taatattagg ttgtttattt                                                   20


<210> 21289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21289
aatctctaag atgtaatatt                                                   20


<210> 21290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21290
taatctctaa gatgtaatat                                                   20


<210> 21291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21291
ttcttctttt tctaatctct                                                   20


<210> 21292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21292
tcttccttct gcaaagtttg                                                   20


<210> 21293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21293
ttcttccttc tgcaaagttt                                                   20


<210> 21294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21294
tttcttcctt ctgcaaagtt                                                   20


<210> 21295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21295
gttattttct tccttctgca                                                   20


<210> 21296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21296
ttttcaaaaa aacaactttt                                                   20


<210> 21297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21297
cccttggtta gtctagttaa                                                   20


<210> 21298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21298
tcccttggtt agtctagtta                                                   20


<210> 21299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21299
cttttttccc ttggttagtc                                                   20


<210> 21300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21300
gttgtctttt ttcccttggt                                                   20


<210> 21301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21301
ttgagttgtc ttttttccct                                                   20


<210> 21302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21302
tttcatttca gatattgttt                                                   20


<210> 21303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21303
tagtctccct tctttcattt                                                   20


<210> 21304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21304
tatttatgtg ttatcagtgt                                                   20


<210> 21305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21305
tccttgtatt tatgtgttat                                                   20


<210> 21306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21306
tgtatggttg ttcacattaa                                                   20


<210> 21307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21307
ttattcaatt tgatggtgta                                                   20


<210> 21308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21308
ttctaggtta ttcaatttga                                                   20


<210> 21309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21309
aagattagtt cattccttct                                                   20


<210> 21310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21310
aaagattagt tcattccttc                                                   20


<210> 21311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21311
ggttgcatgt ttctaaagat                                                   20


<210> 21312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21312
tggtaggttg catgtttcta                                                   20


<210> 21313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21313
tttcttgatt tagtcttggt                                                   20


<210> 21314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21314
atttcttgat ttagtcttgg                                                   20


<210> 21315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21315
aatatttctt gatttagtct                                                   20


<210> 21316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21316
agatgtaata tttcttgatt                                                   20


<210> 21317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21317
ttatccagta ttggtttgtt                                                   20


<210> 21318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21318
ctattttctt tatccagtat                                                   20


<210> 21319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21319
actgatctat tttctttatc                                                   20


<210> 21320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21320
tttttttttt ttttggttag                                                   20


<210> 21321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21321
cctttttttt ttttttggtt                                                   20


<210> 21322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21322
tccttttttt tttttttggt                                                   20


<210> 21323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21323
cttttccttt tttttttttt                                                   20


<210> 21324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21324
cttctttaaa tagaattcac                                                   20


<210> 21325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21325
attcatatta cttctttaaa                                                   20


<210> 21326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21326
attttttgga agaatttgag                                                   20


<210> 21327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21327
tcaatttttt ggaagaattt                                                   20


<210> 21328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21328
cctccttttc aattttttgg                                                   20


<210> 21329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21329
tgacctcctt ttcaattttt                                                   20


<210> 21330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21330
ttttcatatc agtataatac                                                   20


<210> 21331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21331
tactcttagg gttttcatat                                                   20


<210> 21332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21332
tttctggtag catactctta                                                   20


<210> 21333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21333
ttttctggta gcatactctt                                                   20


<210> 21334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21334
cttttctggt agcatactct                                                   20


<210> 21335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21335
cctgcagttt tcttttctgg                                                   20


<210> 21336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21336
tggcctgcag ttttcttttc                                                   20


<210> 21337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21337
tcatcaagaa tattggcctg                                                   20


<210> 21338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21338
tctatgttca tcaagaatat                                                   20


<210> 21339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21339
tttttggatc tatgttcatc                                                   20


<210> 21340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21340
aatatattgt tgtgaatttt                                                   20


<210> 21341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21341
tttaaatgtg ctagggaatt                                                   20


<210> 21342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21342
atgatgtttt aaatgtgcta                                                   20


<210> 21343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21343
aatgatgttt taaatgtgct                                                   20


<210> 21344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21344
gaatgatgtt ttaaatgtgc                                                   20


<210> 21345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21345
agataaatcc caagtaatca                                                   20


<210> 21346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21346
gcatccctca gataaatccc                                                   20


<210> 21347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21347
ttaaccattt ttgcatccct                                                   20


<210> 21348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21348
ttgttcttat tttgttaatg                                                   20


<210> 21349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21349
atgctttgtc tgcatctagt                                                   20


<210> 21350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21350
tcaaatgctt tgtctgcatc                                                   20


<210> 21351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21351
attttattat gaacatatgc                                                   20


<210> 21352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21352
ccttccatat ctgctttgtt                                                   20


<210> 21353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21353
tatatggctt tattttgtta                                                   20


<210> 21354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21354
atatatggct ttattttgtt                                                   20


<210> 21355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21355
agccgtgggc ttgtcatata                                                   20


<210> 21356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21356
ttttgcataa tgttagccgt                                                   20


<210> 21357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21357
tttttgcata atgttagccg                                                   20


<210> 21358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21358
tttcagtttt tgcataatgt                                                   20


<210> 21359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21359
aagaaaagct cccaactttt                                                   20


<210> 21360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21360
tgttcctgat cttagaagaa                                                   20


<210> 21361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21361
tgtcttgttc ctgatcttag                                                   20


<210> 21362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21362
ccttgtcttg ttcctgatct                                                   20


<210> 21363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21363
atgtcaaaaa gaagtggtaa                                                   20


<210> 21364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21364
agtactatgt caaaaagaag                                                   20


<210> 21365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21365
tctagtacta tgtcaaaaag                                                   20


<210> 21366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21366
atttctagta ctatgtcaaa                                                   20


<210> 21367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21367
attgctatgg atgggatttc                                                   20


<210> 21368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21368
cctgcctaat tgctatggat                                                   20


<210> 21369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21369
tcctgcctaa ttgctatgga                                                   20


<210> 21370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21370
tttttcctgc ctaattgcta                                                   20


<210> 21371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21371
ttatttcttg ctttcttaca                                                   20


<210> 21372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21372
gatcatgtca ttagcaaaca                                                   20


<210> 21373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21373
aagatcatgt cattagcaaa                                                   20


<210> 21374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21374
acatataaag atcatgtcat                                                   20


<210> 21375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21375
ttcagggttt tctacatata                                                   20


<210> 21376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21376
agttctcagt agagtgttca                                                   20


<210> 21377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21377
cagttctcag tagagtgttc                                                   20


<210> 21378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21378
acagttctca gtagagtgtt                                                   20


<210> 21379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21379
agttttaaca gttctcagta                                                   20


<210> 21380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21380
tcagttttaa cagttctcag                                                   20


<210> 21381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21381
gtatcagttt taacagttct                                                   20


<210> 21382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21382
aatttatgta tcagttttaa                                                   20


<210> 21383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21383
actttactga atttatgtat                                                   20


<210> 21384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21384
gatacctcat tgttaatgta                                                   20


<210> 21385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21385
taatttctta atttctttgt                                                   20


<210> 21386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21386
attttgatgc tgttttaaat                                                   20


<210> 21387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21387
tattttgatg ctgttttaaa                                                   20


<210> 21388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21388
tcctggttaa atttacttca                                                   20


<210> 21389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21389
gtacagatct tcaactttcc                                                   20


<210> 21390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21390
aacttatagt tttcagtgta                                                   20


<210> 21391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21391
ttaaatcaac ttatagtttt                                                   20


<210> 21392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21392
agttttttta aatcaactta                                                   20


<210> 21393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21393
caatttattt gtgtcttcct                                                   20


<210> 21394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21394
gtagattatt ttgggtagta                                                   20


<210> 21395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21395
aatctgtaga ttattttggg                                                   20


<210> 21396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21396
ttgaatctgt agattatttt                                                   20


<210> 21397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21397
attgaatctg tagattattt                                                   20


<210> 21398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21398
tagggattgc attgaatctg                                                   20


<210> 21399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21399
ctgacattag aattttgata                                                   20


<210> 21400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21400
actgacatta gaattttgat                                                   20


<210> 21401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21401
aactgacatt agaattttga                                                   20


<210> 21402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21402
atttctgtga aaactgacat                                                   20


<210> 21403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21403
ttttatttta ttcaaatgtt                                                   20


<210> 21404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21404
tttttatttt attcaaatgt                                                   20


<210> 21405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21405
ctcagattgc tttggccatt                                                   20


<210> 21406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21406
tctttttgct cagattgctt                                                   20


<210> 21407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21407
ctagctttgt tctttttgct                                                   20


<210> 21408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21408
atgacagagt attgcacctc                                                   20


<210> 21409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21409
ctttatattt tgaaatgaca                                                   20


<210> 21410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21410
agctttatat tttgaaatga                                                   20


<210> 21411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21411
ctgtgtttat gccaatagca                                                   20


<210> 21412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21412
tatatctgtg tttatgccaa                                                   20


<210> 21413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21413
ggctttttat ccttttccat                                                   20


<210> 21414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21414
aaataattgg gtttatttct                                                   20


<210> 21415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21415
taaataattg ggtttatttc                                                   20


<210> 21416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21416
tcaattgact ataaataatt                                                   20


<210> 21417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21417
atcaattgac tataaataat                                                   20


<210> 21418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21418
tcccaacacc atttattgaa                                                   20


<210> 21419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21419
tttcccaaca ccatttattg                                                   20


<210> 21420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21420
tcttttgcat aaggaatatt                                                   20


<210> 21421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21421
caatttcatt cttttgcata                                                   20


<210> 21422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21422
ccaatttcat tcttttgcat                                                   20


<210> 21423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21423
taaacatatg gtatgagaaa                                                   20


<210> 21424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21424
ataaacatat ggtatgagaa                                                   20


<210> 21425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21425
tataaacata tggtatgaga                                                   20


<210> 21426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21426
gttttataaa catatggtat                                                   20


<210> 21427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21427
tgtttggttt tataaacata                                                   20


<210> 21428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21428
atttaagtct tttacttgtt                                                   20


<210> 21429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21429
tagtttcatt tcttatattt                                                   20


<210> 21430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21430
gttttcttct agtagcttta                                                   20


<210> 21431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21431
tcttttatgt tttcttctag                                                   20


<210> 21432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21432
ttttctttta tgttttcttc                                                   20


<210> 21433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21433
ttgcccagat aaatgtcata                                                   20


<210> 21434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21434
ctagccaaga aatccttgcc                                                   20


<210> 21435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21435
gtgcttttag agtcctagcc                                                   20


<210> 21436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21436
tacctgtgct tttagagtcc                                                   20


<210> 21437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21437
ttttgttacc tgtgctttta                                                   20


<210> 21438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21438
tcttttgtta cctgtgcttt                                                   20


<210> 21439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21439
tttgctgtaa agaacatttt                                                   20


<210> 21440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21440
ttattgcttc gtttgctgta                                                   20


<210> 21441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21441
tttatcagat gtatggtttg                                                   20


<210> 21442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21442
ttagcccttt atcagatgta                                                   20


<210> 21443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21443
gttggatatt agccctttat                                                   20


<210> 21444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21444
ttatgtataa tgttggatat                                                   20


<210> 21445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21445
gagcttttta tgtataatgt                                                   20


<210> 21446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21446
ttctaggtgt tgagttgctt                                                   20


<210> 21447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21447
ttattgattt tctaggtgtt                                                   20


<210> 21448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21448
aattggttta ttgattttct                                                   20


<210> 21449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21449
caattggttt attgattttc                                                   20


<210> 21450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21450
ttatttgccc attctacaat                                                   20


<210> 21451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21451
tcttttgaga aatgtctgtt                                                   20


<210> 21452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21452
ccattcatat ctcttctttt                                                   20


<210> 21453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21453
gcatttttta atatatctat                                                   20


<210> 21454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21454
ttctgatgat tagagatgtt                                                   20


<210> 21455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21455
ttgcattttt ctgatgatta                                                   20


<210> 21456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21456
atttgcattt ttctgatgat                                                   20


<210> 21457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21457
gtgtgaggta atatttcatt                                                   20


<210> 21458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21458
ggtgtgaggt aatatttcat                                                   20


<210> 21459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21459
cagccattct aggaggtgtg                                                   20


<210> 21460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21460
acagccattc taggaggtgt                                                   20


<210> 21461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21461
ttgataacag ccattctagg                                                   20


<210> 21462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21462
tttgataaca gccattctag                                                   20


<210> 21463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21463
tttttgataa cagccattct                                                   20


<210> 21464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21464
ctttttgata acagccattc                                                   20


<210> 21465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21465
atcattcatc tttttgataa                                                   20


<210> 21466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21466
ttttcactaa caatgtataa                                                   20


<210> 21467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21467
attttcacta acaatgtata                                                   20


<210> 21468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21468
cattttcact aacaatgtat                                                   20


<210> 21469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21469
tccatgctat ttttctcaaa                                                   20


<210> 21470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21470
atggtaattg tatttgtttt                                                   20


<210> 21471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21471
tatggtaatt gtatttgttt                                                   20


<210> 21472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21472
agtggaattg ctgaattata                                                   20


<210> 21473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21473
taccactata tacctagaag                                                   20


<210> 21474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21474
atataccact atatacctag                                                   20


<210> 21475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21475
aatatatacc actatatacc                                                   20


<210> 21476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21476
aacgatttta attcctctaa                                                   20


<210> 21477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21477
gaacgatttt aattcctcta                                                   20


<210> 21478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21478
gagtgcaggt atacctttga                                                   20


<210> 21479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21479
tgaaatgaac atgggagtgc                                                   20


<210> 21480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21480
ctgaaatgaa catgggagtg                                                   20


<210> 21481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21481
taatgctgaa atgaacatgg                                                   20


<210> 21482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21482
aataatgctg aaatgaacat                                                   20


<210> 21483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21483
aaataatgct gaaatgaaca                                                   20


<210> 21484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21484
tgcaccaacc taatatgtct                                                   20


<210> 21485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21485
tttaattgca gcaaaagtaa                                                   20


<210> 21486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21486
attactttta attgcagcaa                                                   20


<210> 21487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21487
ttggccatta cttttaattg                                                   20


<210> 21488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21488
tgcaaaagta attgcggttt                                                   20


<210> 21489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 21489
ggttagtgca aaagtaattg                                                   20


<210> 21490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21490
gcatgtatgg gttagtgcaa                                                   20


<210> 21491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21491
tacaggttgc atgtatgggt                                                   20


<210> 21492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21492
tgggtacagg ttgcatgtat                                                   20


<210> 21493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21493
atgggtacag gttgcatgta                                                   20


<210> 21494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21494
attcacctgt tgatgggtac                                                   20


<210> 21495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21495
cattcacctg ttgatgggta                                                   20


<210> 21496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21496
ttattcattc acctgttgat                                                   20


<210> 21497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21497
tttattcatt cacctgttga                                                   20


<210> 21498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21498
tcttttaaag ttttgtatag                                                   20


<210> 21499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21499
tgttctttta aagttttgta                                                   20


<210> 21500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21500
tgacaaaatt tgttctttta                                                   20


<210> 21501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21501
cctttagttt cattcatgtt                                                   20


<210> 21502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21502
tcctttagtt tcattcatgt                                                   20


<210> 21503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21503
ttgcttagca taacgtcctt                                                   20


<210> 21504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21504
tgtacctggc taattttgct                                                   20


<210> 21505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21505
ggtatttgtc tttctgtacc                                                   20


<210> 21506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21506
tacatgtaag tgagatcatg                                                   20


<210> 21507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21507
accccatttt acatgtaagt                                                   20


<210> 21508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21508
ccccacccca ttttacatgt                                                   20


<210> 21509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21509
attaactcgt catttacatt                                                   20


<210> 21510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21510
cattaactcg tcatttacat                                                   20


<210> 21511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 21511
acatgtgcca tgttggtgtg                                                   20


<210> 21512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21512
tatgtataca tgtgccatgt                                                   20


<210> 21513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21513
ggtacatgtg cacaacgtgc                                                   20


<210> 21514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21514
gggtacatgt gcacaacgtg                                                   20


<210> 21515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21515
ttattttact ttaagttcta                                                   20


<210> 21516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21516
tttattttac tttaagttct                                                   20


<210> 21517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21517
ttttatttta ctttaagttc                                                   20


<210> 21518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21518
ttattttttt attttacttt                                                   20


<210> 21519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21519
atcgtcttcc cccagtccta                                                   20


<210> 21520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21520
ttctccacat cgtcttcccc                                                   20


<210> 21521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21521
aaaatgtaca tcctttgatc                                                   20


<210> 21522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21522
ttaagtcttt aatccatctt                                                   20


<210> 21523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21523
tagttttaga ttttacattt                                                   20


<210> 21524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21524
ttccagggtt tttatagttt                                                   20


<210> 21525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21525
gctgtcttcc agggttttta                                                   20


<210> 21526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21526
attgcctagg ctgtcttcca                                                   20


<210> 21527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21527
tattgcctag gctgtcttcc                                                   20


<210> 21528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21528
gtattgccta ggctgtcttc                                                   20


<210> 21529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21529
tgtcctgaat ggtattgcct                                                   20


<210> 21530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21530
atgtcctgaa tggtattgcc                                                   20


<210> 21531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21531
gcccatgcct atgtcctgaa                                                   20


<210> 21532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21532
gtttttgttg cagttgcttt                                                   20


<210> 21533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21533
gttaattttt gtttttgttg                                                   20


<210> 21534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21534
cagaagctct ttagtttaat                                                   20


<210> 21535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21535
tttgctgtgc agaagctctt                                                   20


<210> 21536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21536
tagtttcttt tgctgtgcag                                                   20


<210> 21537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21537
tgatagtttc ttttgctgtg                                                   20


<210> 21538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21538
ctgtctgctt actctgttga                                                   20


<210> 21539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21539
aaaaattttc tcccattctg                                                   20


<210> 21540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21540
ttagaccttt gtcagatgca                                                   20


<210> 21541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21541
tctggatatt agacctttgt                                                   20


<210> 21542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21542
tccttataga ttctggatat                                                   20


<210> 21543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21543
tttaagttcc ttatagattc                                                   20


<210> 21544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21544
aaactcattt aagttcctta                                                   20


<210> 21545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21545
tatttcttgt aaactcattt                                                   20


<210> 21546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21546
cctttgccca ctttttaatg                                                   20


<210> 21547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21547
tcctttgccc actttttaat                                                   20


<210> 21548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21548
atcctttgcc cactttttaa                                                   20


<210> 21549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21549
catgtgtgtc ttcttttcag                                                   20


<210> 21550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21550
ttgcatgtgt gtcttctttt                                                   20


<210> 21551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21551
ctctaatggt cagtgacatt                                                   20


<210> 21552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21552
atttgcattt ctctaatggt                                                   20


<210> 21553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21553
tttgatttgc atttctctaa                                                   20


<210> 21554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21554
tgtgagatgg tatctcattg                                                   20


<210> 21555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21555
ccattctgac tggtgtgaga                                                   20


<210> 21556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21556
atagccattc tgactggtgt                                                   20


<210> 21557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21557
ttcataatag ccattctgac                                                   20


<210> 21558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21558
attttttgac tttttcataa                                                   20


<210> 21559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21559
ttttttctcc acaccctcgc                                                   20


<210> 21560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21560
cactcccatc aacagtgtgt                                                   20


<210> 21561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21561
acactcccat caacagtgtg                                                   20


<210> 21562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21562
ttaatttaca ctcccatcaa                                                   20


<210> 21563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21563
tgccacacag tcttccatta                                                   20


<210> 21564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21564
gtctttgagg aattgccaca                                                   20


<210> 21565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21565
tttctgtctt taggtctttg                                                   20


<210> 21566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21566
atttctgtct ttaggtcttt                                                   20


<210> 21567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21567
tgaatggcat ttctgtcttt                                                   20


<210> 21568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21568
ttgaatggca tttctgtctt                                                   20


<210> 21569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21569
aatgggattg ctgggttgaa                                                   20


<210> 21570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21570
tacccagtaa tgggattgct                                                   20


<210> 21571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21571
atacccagta atgggattgc                                                   20


<210> 21572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21572
ttaggtatat acccagtaat                                                   20


<210> 21573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21573
tttaggtata tacccagtaa                                                   20


<210> 21574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21574
tttcccttta ggtatatacc                                                   20


<210> 21575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21575
agaaaaatgt atttcccttt                                                   20


<210> 21576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21576
tagaaaaatg tatttccctt                                                   20


<210> 21577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21577
gtgtgcatgt gtctttataa                                                   20


<210> 21578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21578
tatgtctttg ccattgtgaa                                                   20


<210> 21579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21579
tctatcactg atggtcattt                                                   20


<210> 21580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21580
tttatccagt ctatcactga                                                   20


<210> 21581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21581
tttaccacat tatctttatc                                                   20


<210> 21582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21582
aatggctgca tagtattata                                                   20


<210> 21583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21583
tttttttttg aatggctgca                                                   20


<210> 21584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21584
tgatctcgtt tttttttgaa                                                   20


<210> 21585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21585
ctccattcat gtccctgcaa                                                   20


<210> 21586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21586
gctccattca tgtccctgca                                                   20


<210> 21587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21587
ttactaatga aaatggcctc                                                   20


<210> 21588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21588
ccttagttta ctaatgaaaa                                                   20


<210> 21589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21589
ttggttttct gttcctgcct                                                   20


<210> 21590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21590
aagtgagaac atgtggtatt                                                   20


<210> 21591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21591
cacttataag tgagaacatg                                                   20


<210> 21592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21592
tttagctccc acttataagt                                                   20


<210> 21593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21593
atcatttagc tcccacttat                                                   20


<210> 21594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21594
gtccatgtgt tctcatcatt                                                   20


<210> 21595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21595
cttcaccctc ccataggccc                                                   20


<210> 21596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21596
cccacccttc accctcccat                                                   20


<210> 21597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21597
tcccaccctt caccctccca                                                   20


<210> 21598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21598
gtattaatcc cagtatgcat                                                   20


<210> 21599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21599
catccctgag gtattaatcc                                                   20


<210> 21600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21600
tacagattat ttcatccctg                                                   20


<210> 21601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21601
gtacagatta tttcatccct                                                   20


<210> 21602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21602
tgtcataggg gtttgttgta                                                   20


<210> 21603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21603
cataggtaaa catgtcatag                                                   20


<210> 21604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21604
acataggtaa acatgtcata                                                   20


<210> 21605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21605
tacataggta aacatgtcat                                                   20


<210> 21606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21606
ttacataggt aaacatgtca                                                   20


<210> 21607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21607
gatgtgcagt cttgttacat                                                   20


<210> 21608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21608
ggatgtgcag tcttgttaca                                                   20


<210> 21609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21609
gggtacatgt acaggatgtg                                                   20


<210> 21610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21610
aagttcaggg gtacatgtac                                                   20


<210> 21611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21611
taagttcagg ggtacatgta                                                   20


<210> 21612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21612
gacttttatt ttaagttcag                                                   20


<210> 21613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21613
tgacttttat tttaagttca                                                   20


<210> 21614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21614
ttgactttta ttttaagttc                                                   20


<210> 21615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21615
tttgactttt attttaagtt                                                   20


<210> 21616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21616
acttttttga cttttatttt                                                   20


<210> 21617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21617
aagttaaaaa gctattcttt                                                   20


<210> 21618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21618
tttgtggtaa gaaagttaaa                                                   20


<210> 21619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21619
atcatttttt tgtggtaaga                                                   20


<210> 21620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21620
acttatcatt tttttgtggt                                                   20


<210> 21621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21621
acccacttat catttttttg                                                   20


<210> 21622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21622
ataaacattg tagaaatttt                                                   20


<210> 21623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21623
tttgatctac ataaacattg                                                   20


<210> 21624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21624
aaaaattgtg cttatttatg                                                   20


<210> 21625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21625
caaaaattgt gcttatttat                                                   20


<210> 21626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21626
acaaaaattg tgcttattta                                                   20


<210> 21627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21627
tcatcaggga tcttgttctg                                                   20


<210> 21628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21628
atttgcatct atgttcatca                                                   20


<210> 21629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21629
tatttgcatc tatgttcatc                                                   20


<210> 21630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21630
ttatttgcat ctatgttcat                                                   20


<210> 21631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21631
agtttgctaa tattttgatg                                                   20


<210> 21632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21632
atttaatggg ctgttgcatt                                                   20


<210> 21633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21633
gtagtacatg atcatttaat                                                   20


<210> 21634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21634
cgtagtacat gatcatttaa                                                   20


<210> 21635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21635
ggacaactcc cacttggtcg                                                   20


<210> 21636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21636
tcctagggac aactcccact                                                   20


<210> 21637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21637
tgaaccatcc ttgcatccta                                                   20


<210> 21638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21638
ttgaaccatc cttgcatcct                                                   20


<210> 21639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21639
gttgaaccat ccttgcatcc                                                   20


<210> 21640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21640
catgtggtgt atcacattat                                                   20


<210> 21641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21641
tttatccttc tcagatcatg                                                   20


<210> 21642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21642
catgtgattt ttatccttct                                                   20


<210> 21643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21643
tttttagttt ttaccatgaa                                                   20


<210> 21644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21644
ttttttagtt tttaccatga                                                   20


<210> 21645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21645
tagcttttgt tttctttttt                                                   20


<210> 21646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21646
gttatagcaa cttctatacc                                                   20


<210> 21647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21647
ggggacaaac cttcaagtta                                                   20


<210> 21648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21648
tttggagggg acaaaccttc                                                   20


<210> 21649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21649
ttgcaacatg agctttggag                                                   20


<210> 21650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21650
attgcaacat gagctttgga                                                   20


<210> 21651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21651
aattgcaaca tgagctttgg                                                   20


<210> 21652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21652
aaattgcaac atgagctttg                                                   20


<210> 21653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21653
ttaaattgca acatgagctt                                                   20


<210> 21654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21654
ttgcaattaa attgcaacat                                                   20


<210> 21655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21655
ataacttaaa cacctcttaa                                                   20


<210> 21656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21656
cataacttaa acacctctta                                                   20


<210> 21657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21657
cagcattaat gcatttaaaa                                                   20


<210> 21658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21658
acagcattaa tgcatttaaa                                                   20


<210> 21659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21659
aacagcatta atgcatttaa                                                   20


<210> 21660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21660
tgaactcaat cctgagataa                                                   20


<210> 21661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21661
tttataatga actcaatcct                                                   20


<210> 21662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21662
gaataagtga gaaaaggagg                                                   20


<210> 21663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21663
agagaataag tgagaaaagg                                                   20


<210> 21664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21664
gagagaataa gtgagaaaag                                                   20


<210> 21665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21665
aagagagaat aagtgagaaa                                                   20


<210> 21666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21666
aaagagagaa taagtgagaa                                                   20


<210> 21667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21667
ggcacaaaga gagaataagt                                                   20


<210> 21668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21668
acatggcaca aagagagaat                                                   20


<210> 21669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21669
tgatacacat ggcacaaaga                                                   20


<210> 21670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21670
tatgatacac atggcacaaa                                                   20


<210> 21671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21671
gttatgatac acatggcaca                                                   20


<210> 21672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21672
gtatcatgtt atgatacaca                                                   20


<210> 21673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21673
ttgtgtcata acatgctgta                                                   20


<210> 21674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21674
gttgtgtcat aacatgctgt                                                   20


<210> 21675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21675
gactgagggg ctgtctggtg                                                   20


<210> 21676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21676
tgactgaggg gctgtctggt                                                   20


<210> 21677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21677
ttcatgactg aggggctgtc                                                   20


<210> 21678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21678
atggaaagtt catgactgag                                                   20


<210> 21679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21679
gatggaaagt tcatgactga                                                   20


<210> 21680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21680
ggatggaaag ttcatgactg                                                   20


<210> 21681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21681
aggatggaaa gttcatgact                                                   20


<210> 21682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21682
tcacagtact ggaggatgga                                                   20


<210> 21683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21683
gggatcacag tactggagga                                                   20


<210> 21684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21684
ttatgggatc acagtactgg                                                   20


<210> 21685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21685
cttatgggat cacagtactg                                                   20


<210> 21686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21686
accttatggg atcacagtac                                                   20


<210> 21687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21687
acataaacct tatgggatca                                                   20


<210> 21688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21688
ataatgaaca taaaccttat                                                   20


<210> 21689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21689
tataatgaac ataaacctta                                                   20


<210> 21690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21690
ataacagaat accacagact                                                   20


<210> 21691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21691
tataacagaa taccacagac                                                   20


<210> 21692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21692
gctactataa cagaatacca                                                   20


<210> 21693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21693
atccatttgt gctactataa                                                   20


<210> 21694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21694
aagtagtctt tgttatcatg                                                   20


<210> 21695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21695
ttagctgtgg gattttcaag                                                   20


<210> 21696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21696
atgttagctg tgggattttc                                                   20


<210> 21697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21697
ttgaatacga tgttagctgt                                                   20


<210> 21698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21698
attgaatacg atgttagctg                                                   20


<210> 21699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21699
ttcaccattg aatacgatgt                                                   20


<210> 21700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21700
gatcttacag gaaagttttt                                                   20


<210> 21701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21701
ttattcctga tcttacagga                                                   20


<210> 21702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21702
tgtcttattc ctgatcttac                                                   20


<210> 21703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21703
ttgtcttatt cctgatctta                                                   20


<210> 21704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21704
ttaaatacaa gtggcaagag                                                   20


<210> 21705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21705
gtgttaaata caagtggcaa                                                   20


<210> 21706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21706
ctgtgttaaa tacaagtggc                                                   20


<210> 21707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21707
agtgctgtgt taaatacaag                                                   20


<210> 21708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21708
tctagtgctg tgttaaatac                                                   20


<210> 21709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21709
atttctctgg ctaggacttc                                                   20


<210> 21710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21710
cttgcctaat ttctctggct                                                   20


<210> 21711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21711
tcttgcctaa tttctctggc                                                   20


<210> 21712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21712
tttttcttgc ctaatttctc                                                   20


<210> 21713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21713
acactttttt ctttcagatt                                                   20


<210> 21714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21714
aacacttttt tctttcagat                                                   20


<210> 21715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21715
ctgtaaacac ttttttcttt                                                   20


<210> 21716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21716
cctgatgtgt ggagtcttta                                                   20


<210> 21717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21717
tcctgatgtg tggagtcttt                                                   20


<210> 21718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21718
ttcctgatgt gtggagtctt                                                   20


<210> 21719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21719
acagattttc ctgatgtgtg                                                   20


<210> 21720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21720
taacagattt tcctgatgtg                                                   20


<210> 21721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21721
aatttgttta ttagttctaa                                                   20


<210> 21722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21722
catctagtaa atttgtttat                                                   20


<210> 21723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21723
attttatatc cttcaacatc                                                   20


<210> 21724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21724
ttgttagtgt atagaaacgc                                                   20


<210> 21725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21725
attgttagtg tatagaaacg                                                   20


<210> 21726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21726
gattgtttat tgttagtgta                                                   20


<210> 21727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21727
ctcttcagat tgtttattgt                                                   20


<210> 21728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21728
ttctttccta attttctctt                                                   20


<210> 21729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21729
cttttgatgt tatcataaat                                                   20


<210> 21730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21730
tcttttgatg ttatcataaa                                                   20


<210> 21731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21731
gccttggtta agcatatcct                                                   20


<210> 21732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21732
acattttcaa tgccttggtt                                                   20


<210> 21733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21733
tgcatacatt ttcaatgcct                                                   20


<210> 21734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21734
catgaacatt ttgtagtttt                                                   20


<210> 21735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21735
tttccttcat gaacattttg                                                   20


<210> 21736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21736
tcatttaatt cgtgaatact                                                   20


<210> 21737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21737
gtcatttaat tcgtgaatac                                                   20


<210> 21738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21738
atgggcattt taacaatatt                                                   20


<210> 21739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21739
cagatcactt agggtagtat                                                   20


<210> 21740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21740
acagatcact tagggtagta                                                   20


<210> 21741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21741
aattcacaga tcacttaggg                                                   20


<210> 21742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21742
ttgaattcac agatcactta                                                   20


<210> 21743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21743
attgaattca cagatcactt                                                   20


<210> 21744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21744
tattgaattc acagatcact                                                   20


<210> 21745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21745
tatgtactgt attgaattca                                                   20


<210> 21746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21746
ttttagtaaa taatgctatt                                                   20


<210> 21747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21747
attttagtaa ataatgctat                                                   20


<210> 21748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21748
tttaggatct ttttttattt                                                   20


<210> 21749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21749
tgtggttcca tatgaatttt                                                   20


<210> 21750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21750
ttgtggttcc atatgaattt                                                   20


<210> 21751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21751
tggctattca gagtcttttg                                                   20


<210> 21752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21752
aagattgctt tggctattca                                                   20


<210> 21753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21753
ttaagattgc tttggctatt                                                   20


<210> 21754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21754
cttttttctt aagattgctt                                                   20


<210> 21755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21755
ccattttgtt cttttttctt                                                   20


<210> 21756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21756
taaataaata aataagaaat                                                   20


<210> 21757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21757
ctctcaataa ataaataaat                                                   20


<210> 21758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21758
tctggcctgg gcaacagggt                                                   20


<210> 21759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21759
gcactctggc ctgggcaaca                                                   20


<210> 21760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21760
tgcactctgg cctgggcaac                                                   20


<210> 21761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21761
ctgcactctg gcctgggcaa                                                   20


<210> 21762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21762
atgccactgc actctggcct                                                   20


<210> 21763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21763
catgccactg cactctggcc                                                   20


<210> 21764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21764
atgatcatgc cactgcactc                                                   20


<210> 21765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21765
caagagtatg aggctgcagt                                                   20


<210> 21766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21766
agcccaagag tatgaggctg                                                   20


<210> 21767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21767
cactgaagcc caagagtatg                                                   20


<210> 21768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21768
tcactgaagc ccaagagtat                                                   20


<210> 21769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21769
ggaggatcac tgaagcccaa                                                   20


<210> 21770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21770
tgggaggatc actgaagccc                                                   20


<210> 21771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21771
ctgaggtggg aggatcactg                                                   20


<210> 21772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21772
acttaggagc ctgaggtggg                                                   20


<210> 21773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21773
tacttaggag cctgaggtgg                                                   20


<210> 21774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21774
gctacttagg agcctgaggt                                                   20


<210> 21775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21775
agctacttag gagcctgagg                                                   20


<210> 21776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21776
cctagctact taggagcctg                                                   20


<210> 21777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21777
tcctagctac ttaggagcct                                                   20


<210> 21778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21778
ctatagtcct agctacttag                                                   20


<210> 21779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21779
acctatagtc ctagctactt                                                   20


<210> 21780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21780
cacctatagt cctagctact                                                   20


<210> 21781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21781
atggcacaca cctatagtcc                                                   20


<210> 21782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21782
agcatgatgg cacacaccta                                                   20


<210> 21783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21783
tgaaaagtag ccaagcatga                                                   20


<210> 21784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21784
aagatatttg aaaagtagcc                                                   20


<210> 21785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21785
ttacgaagat atttgaaaag                                                   20


<210> 21786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21786
tctttacgaa gatatttgaa                                                   20


<210> 21787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21787
agatagactc cttctttacg                                                   20


<210> 21788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21788
tgagaccagc ctgggcaaga                                                   20


<210> 21789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21789
agtttgagac cagcctgggc                                                   20


<210> 21790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21790
caagagtttg agaccagcct                                                   20


<210> 21791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21791
ccaagagttt gagaccagcc                                                   20


<210> 21792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21792
tgtggccaag agtttgagac                                                   20


<210> 21793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21793
tcacttgtgg ccaagagttt                                                   20


<210> 21794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21794
ggaggatcac ttgtggccaa                                                   20


<210> 21795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21795
ctggaggatc acttgtggcc                                                   20


<210> 21796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21796
taaggctgga ggatcacttg                                                   20


<210> 21797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21797
actcgggagg ctaaggctgg                                                   20


<210> 21798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21798
aactcgggag gctaaggctg                                                   20


<210> 21799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21799
gcaactcggg aggctaaggc                                                   20


<210> 21800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21800
cccagcaact cgggaggcta                                                   20


<210> 21801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21801
tcccagcaac tcgggaggct                                                   20


<210> 21802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21802
tataatccca gcaactcggg                                                   20


<210> 21803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21803
ttataatccc agcaactcgg                                                   20


<210> 21804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21804
gcttataatc ccagcaactc                                                   20


<210> 21805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 21805
tgcttataat cccagcaact                                                   20


<210> 21806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21806
atggctcatg cttataatcc                                                   20


<210> 21807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21807
cctgtgggga ctgggtgcaa                                                   20


<210> 21808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21808
aatgaggacc tgtggggact                                                   20


<210> 21809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21809
aaatgaggac ctgtggggac                                                   20


<210> 21810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21810
ttttgaaatg aggacctgtg                                                   20


<210> 21811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21811
attttgaaat gaggacctgt                                                   20


<210> 21812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21812
cattttgaaa tgaggacctg                                                   20


<210> 21813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21813
ttgttataca ttttgaaatg                                                   20


<210> 21814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21814
tttgttatac attttgaaat                                                   20


<210> 21815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21815
ccatactatt ttaattgttg                                                   20


<210> 21816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21816
ctatatattt gttttatgcc                                                   20


<210> 21817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21817
cctatatatt tgttttatgc                                                   20


<210> 21818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21818
ggctctctat cctgtttcat                                                   20


<210> 21819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21819
ttatgcatgg gtttatttct                                                   20


<210> 21820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21820
tttatgcatg ggtttatttc                                                   20


<210> 21821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21821
tgagttaact atttatgcat                                                   20


<210> 21822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21822
atgagttaac tatttatgca                                                   20


<210> 21823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21823
ttggcacccc tgttgaatat                                                   20


<210> 21824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21824
tcttttctat tgtgtattct                                                   20


<210> 21825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21825
tcccaacatt atttgttgag                                                   20


<210> 21826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21826
ttttcccaac attatttgtt                                                   20


<210> 21827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21827
tttttttata tgtgaatatc                                                   20


<210> 21828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21828
ttttgtgtat ggtataatat                                                   20


<210> 21829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21829
tttgagttta tttttgtgta                                                   20


<210> 21830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21830
ttaaatgttt aatctatttt                                                   20


<210> 21831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21831
ttttacagtt ttcaggtctt                                                   20


<210> 21832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21832
gttttacagt tttcaggtct                                                   20


<210> 21833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21833
ctacaagttt tacagttttc                                                   20


<210> 21834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21834
tctacaagtt ttacagtttt                                                   20


<210> 21835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21835
gttttcttct acaagtttta                                                   20


<210> 21836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21836
cctgctatgt tttcttctac                                                   20


<210> 21837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21837
ttgtcaagaa cagtatcatg                                                   20


<210> 21838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21838
caagaaatca ttgtcaagaa                                                   20


<210> 21839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21839
attgccaaga aatcattgtc                                                   20


<210> 21840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21840
tgaattttgg agtcattgcc                                                   20


<210> 21841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21841
ttgctcttgt ttgaattttg                                                   20


<210> 21842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21842
ttttgctctt gtttgaattt                                                   20


<210> 21843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21843
caaagctttt tagtttgata                                                   20


<210> 21844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21844
ctttttttcc caaagctttt                                                   20


<210> 21845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21845
aatgcttcct ttttttccca                                                   20


<210> 21846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21846
aatattttct cccattctat                                                   20


<210> 21847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21847
aaatattttc tcccattcta                                                   20


<210> 21848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21848
ccatttatta gatatatagt                                                   20


<210> 21849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21849
ttaaccattt attagatata                                                   20


<210> 21850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21850
tttggatatt aaccatttat                                                   20


<210> 21851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21851
caggagttcc ctatatattt                                                   20


<210> 21852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21852
catgccttct taagttgcag                                                   20


<210> 21853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21853
tgcatgcctt cttaagttgc                                                   20


<210> 21854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21854
ttgcatgcct tcttaagttg                                                   20


<210> 21855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21855
ggtcatttgc atgccttctt                                                   20


<210> 21856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21856
gcatctttta atatacatgt                                                   20


<210> 21857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21857
ttctgatgat tagtgatact                                                   20


<210> 21858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21858
tatttgaatt ttctgatgat                                                   20


<210> 21859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21859
actgcacctg gccctcatta                                                   20


<210> 21860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21860
caggcatgag ccactgcacc                                                   20


<210> 21861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21861
agtgctggga taacaggcat                                                   20


<210> 21862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21862
tcccaaagtg ctgggataac                                                   20


<210> 21863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21863
ctcccaaagt gctgggataa                                                   20


<210> 21864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21864
ccttggcctc ccaaagtgct                                                   20


<210> 21865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21865
accttggcct cccaaagtgc                                                   20


<210> 21866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21866
ccacccacct tggcctccca                                                   20


<210> 21867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21867
acctcatgat ccacccacct                                                   20


<210> 21868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21868
tttcaccatt ttggccagga                                                   20


<210> 21869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21869
ggagtttcac cattttggcc                                                   20


<210> 21870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21870
tggagtttca ccattttggc                                                   20


<210> 21871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21871
gagatggagt ttcaccattt                                                   20


<210> 21872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21872
ttgtattttc agtagagatg                                                   20


<210> 21873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21873
ttttgtattt tcagtagaga                                                   20


<210> 21874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21874
taatttttgt attttcagta                                                   20


<210> 21875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21875
gctaattttt gtattttcag                                                   20


<210> 21876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21876
ccagctaatt tttgtatttt                                                   20


<210> 21877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21877
caggcatgtg ccaccatgcc                                                   20


<210> 21878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21878
tcccaagtag ctgggattac                                                   20


<210> 21879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21879
ttcccaagta gctgggatta                                                   20


<210> 21880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21880
cctcagcttc ccaagtagct                                                   20


<210> 21881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21881
gcctcagctt cccaagtagc                                                   20


<210> 21882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21882
tcctgcctca gcttcccaag                                                   20


<210> 21883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21883
ttctcctgcc tcagcttccc                                                   20


<210> 21884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21884
ttcaagtgat tctcctgcct                                                   20


<210> 21885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21885
aacctccgac tccctggttc                                                   20


<210> 21886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21886
cactgcaacc tccgactccc                                                   20


<210> 21887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21887
ggagtgcagt ggcgcgatct                                                   20


<210> 21888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21888
gtcaccaggc tggagtgcag                                                   20


<210> 21889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21889
tctgtcacca ggctggagtg                                                   20


<210> 21890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21890
ctcactctgt caccaggctg                                                   20


<210> 21891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21891
gtctcactct gtcaccaggc                                                   20


<210> 21892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21892
aggagtctca ctctgtcacc                                                   20


<210> 21893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21893
aaggagtctc actctgtcac                                                   20


<210> 21894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21894
ttgtttgttt gtttttgaag                                                   20


<210> 21895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21895
gtttgtttgt ttgtttttga                                                   20


<210> 21896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21896
tgtttgtttg tttgtttttg                                                   20


<210> 21897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 21897
caggcgtgag ccaccacgcc                                                   20


<210> 21898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21898
agtgctggga ttacaggcgt                                                   20


<210> 21899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21899
tcccaaagtg ctgggattac                                                   20


<210> 21900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21900
ctcccaaagt gctgggatta                                                   20


<210> 21901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21901
tctcggcctc ccaaagtgct                                                   20


<210> 21902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21902
gtctcggcct cccaaagtgc                                                   20


<210> 21903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21903
ccgcccgtct cggcctccca                                                   20


<210> 21904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 21904
acctcgtgat ccgcccgtct                                                   20


<210> 21905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21905
tttcaccctg ttagccagga                                                   20


<210> 21906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21906
ggggtttcac cctgttagcc                                                   20


<210> 21907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21907
cggggtttca ccctgttagc                                                   20


<210> 21908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21908
gagacggggt ttcaccctgt                                                   20


<210> 21909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21909
ttgtattttt agtagagacg                                                   20


<210> 21910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21910
tttgtatttt tagtagagac                                                   20


<210> 21911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 21911
ttttgtattt ttagtagaga                                                   20


<210> 21912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21912
taatttttgt atttttagta                                                   20


<210> 21913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21913
gctaattttt gtatttttag                                                   20


<210> 21914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21914
ccggctaatt tttgtatttt                                                   20


<210> 21915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 21915
caggcgtgcg ccaccatgcc                                                   20


<210> 21916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21916
tcccgtgtag ctgggactac                                                   20


<210> 21917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21917
ctcccgtgta gctgggacta                                                   20


<210> 21918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21918
cctcagcctc ccgtgtagct                                                   20


<210> 21919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21919
gcctcagcct cccgtgtagc                                                   20


<210> 21920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21920
tcctgcctca gcctcccgtg                                                   20


<210> 21921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21921
ttcacgccat tctcctgcct                                                   20


<210> 21922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21922
cactgcaagc tccgcctccc                                                   20


<210> 21923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 21923
tcactgcaag ctccgcctcc                                                   20


<210> 21924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21924
gcgcgatctc gactcactgc                                                   20


<210> 21925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21925
tcgcccaggc tggagtgcag                                                   20


<210> 21926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21926
ctgtcgccca ggctggagtg                                                   20


<210> 21927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21927
tcgctctgtc gcccaggctg                                                   20


<210> 21928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21928
tttcgctctg tcgcccaggc                                                   20


<210> 21929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21929
ggagtttcgc tctgtcgccc                                                   20


<210> 21930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21930
cggagtttcg ctctgtcgcc                                                   20


<210> 21931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21931
ttgttttttt ttttgagacg                                                   20


<210> 21932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 21932
tgttgttttt ttttttgaga                                                   20


<210> 21933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21933
tttttgttgt tttttttttt                                                   20


<210> 21934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 21934
tatgaaatga tatctcttta                                                   20


<210> 21935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21935
ttggtaatag ccatcctagc                                                   20


<210> 21936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21936
tttggtaata gccatcctag                                                   20


<210> 21937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21937
tgttttggta atagccatcc                                                   20


<210> 21938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21938
ttttgttttt gttttggtaa                                                   20


<210> 21939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21939
ggtggttttt gtttttgttt                                                   20


<210> 21940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21940
ctattatctt ttgatttggg                                                   20


<210> 21941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 21941
cacctattat cttttgattt                                                   20


<210> 21942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21942
acacctatta tcttttgatt                                                   20


<210> 21943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21943
tacattccaa caatgtacaa                                                   20


<210> 21944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21944
ttacattcca acaatgtaca                                                   20


<210> 21945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21945
tttcatactg ttttctatgg                                                   20


<210> 21946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21946
aactttcata ctgttttcta                                                   20


<210> 21947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21947
gttatatttt taattttttc                                                   20


<210> 21948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21948
agttatattt ttaatttttt                                                   20


<210> 21949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21949
ggcattgcta gatcaaatgg                                                   20


<210> 21950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21950
tgtggcattg ctagatcaaa                                                   20


<210> 21951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21951
atgctcagat gtggcattgc                                                   20


<210> 21952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21952
ttttaaaata tgctcagatg                                                   20


<210> 21953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21953
tcaaattttt aaaatatgct                                                   20


<210> 21954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21954
agtaaggact ctgagatcct                                                   20


<210> 21955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21955
aacatggaag taaggactct                                                   20


<210> 21956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21956
ctgaagtgaa catggaagta                                                   20


<210> 21957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21957
gctgaagtga acatggaagt                                                   20


<210> 21958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21958
tagtgctgaa gtgaacatgg                                                   20


<210> 21959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21959
aaatagtgct gaagtgaaca                                                   20


<210> 21960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21960
ggatacagta aatagtgctg                                                   20


<210> 21961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21961
tcatatttgg atacagtaaa                                                   20


<210> 21962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21962
gttgttttca tatttggata                                                   20


<210> 21963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21963
atttaggttg ttttcatatt                                                   20


<210> 21964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21964
tcattcatca atagacattt                                                   20


<210> 21965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21965
atcattcatc aatagacatt                                                   20


<210> 21966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21966
tctatcccat cattcatcaa                                                   20


<210> 21967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21967
gtacgtgcac acgcacatgc                                                   20


<210> 21968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21968
tgtacgtgca cacgcacatg                                                   20


<210> 21969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21969
tccttcttta taaggctgaa                                                   20


<210> 21970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21970
gcaggatttc cttctttata                                                   20


<210> 21971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21971
ggcaggattt ccttctttat                                                   20


<210> 21972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21972
ttcaagttgc tgcatatggc                                                   20


<210> 21973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21973
attcaagttg ctgcatatgg                                                   20


<210> 21974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21974
ttcattcaag ttgctgcata                                                   20


<210> 21975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21975
aaatttatcc aggttcattc                                                   20


<210> 21976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21976
cactcagcat aaatttatcc                                                   20


<210> 21977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21977
tcactcagca taaatttatc                                                   20


<210> 21978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21978
attttttctg ttacttcact                                                   20


<210> 21979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21979
ttttagttac ttcaccgaag                                                   20


<210> 21980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21980
ccattttagt tacttcaccg                                                   20


<210> 21981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21981
ttccatgagt ttgaccattt                                                   20


<210> 21982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21982
attcttctct ctgtttccat                                                   20


<210> 21983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21983
tctcccatcc tttcatgccc                                                   20


<210> 21984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21984
gaaactttat tcccattgaa                                                   20


<210> 21985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21985
gaagtactac aggaagtccc                                                   20


<210> 21986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21986
tagttacgaa gtactacagg                                                   20


<210> 21987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21987
ctatagttac gaagtactac                                                   20


<210> 21988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 21988
actatagtta cgaagtacta                                                   20


<210> 21989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21989
tattgttaac tatagttacg                                                   20


<210> 21990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21990
actatatata ttgttaacta                                                   20


<210> 21991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21991
acctgcttaa caaaattttt                                                   20


<210> 21992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 21992
gtggtaagga aacttaatat                                                   20


<210> 21993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 21993
taattttaat tattgtggta                                                   20


<210> 21994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21994
ctaattttaa ttattgtggt                                                   20


<210> 21995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21995
tttcctaatt ttaattattg                                                   20


<210> 21996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 21996
agaaaaaaaa caaatgaaag                                                   20


<210> 21997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21997
caaagaaaaa aaacaaatga                                                   20


<210> 21998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 21998
tgatgaactc atttattcca                                                   20


<210> 21999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 21999
tgctatgtag aagtacgtag                                                   20


<210> 22000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22000
acatgctatg tagaagtacg                                                   20


<210> 22001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22001
agttaacaca tgctatgtag                                                   20


<210> 22002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22002
attagttaac acatgctatg                                                   20


<210> 22003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22003
aacatgacca acacttcaat                                                   20


<210> 22004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22004
ctgacctttt ctgaatgatt                                                   20


<210> 22005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22005
ttcatcttgc aatctaagta                                                   20


<210> 22006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22006
agtatttcat cttgcaatct                                                   20


<210> 22007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22007
catatcccct atcattcttc                                                   20


<210> 22008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22008
ggaaacagtt actgatttag                                                   20


<210> 22009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22009
tcaggaaaca gttactgatt                                                   20


<210> 22010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22010
tcaccaccaa agtcaggaaa                                                   20


<210> 22011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22011
atactatcac caccaaagtc                                                   20


<210> 22012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22012
gatactatca ccaccaaagt                                                   20


<210> 22013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22013
ggttgatact atcaccacca                                                   20


<210> 22014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22014
tgcaggaagt aaaataggat                                                   20


<210> 22015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22015
ctgcaggaag taaaatagga                                                   20


<210> 22016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22016
tctactgcag gaagtaaaat                                                   20


<210> 22017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22017
ttctactgca ggaagtaaaa                                                   20


<210> 22018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22018
tacaacattt ctactgcagg                                                   20


<210> 22019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22019
tcttacaaca tttctactgc                                                   20


<210> 22020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22020
ttcttacaac atttctactg                                                   20


<210> 22021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22021
cagtatgagc ataaataaaa                                                   20


<210> 22022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22022
gtgtctagaa agagcagtat                                                   20


<210> 22023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22023
ttaagcgtgt ctagaaagag                                                   20


<210> 22024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22024
aaattaagcg tgtctagaaa                                                   20


<210> 22025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22025
ataaattaag cgtgtctaga                                                   20


<210> 22026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22026
taggataaat taagcgtgtc                                                   20


<210> 22027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22027
ttccctgcat aggataaatt                                                   20


<210> 22028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22028
ttcctcagtc ttccctgcat                                                   20


<210> 22029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22029
attcctcagt cttccctgca                                                   20


<210> 22030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22030
agcacacaca agtaattcct                                                   20


<210> 22031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22031
tgtaatatat aagcacacac                                                   20


<210> 22032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22032
tatacataca tgtaatatat                                                   20


<210> 22033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22033
caatttattt ttctcaactt                                                   20


<210> 22034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22034
tgttccattt tacatttata                                                   20


<210> 22035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22035
aatacagatg tttattttta                                                   20


<210> 22036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22036
tatcctgaca tttacaaata                                                   20


<210> 22037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22037
tttgcaagta gacaaaaatt                                                   20


<210> 22038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22038
catgattgac tatttgcaag                                                   20


<210> 22039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22039
gtgcatgatt gactatttgc                                                   20


<210> 22040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22040
tacatgtacc aaaatgtcat                                                   20


<210> 22041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22041
tggcttagca tctaagaaga                                                   20


<210> 22042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22042
gtactggctt agcatctaag                                                   20


<210> 22043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22043
tgggtactgg cttagcatct                                                   20


<210> 22044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22044
aataattttg ggtactggct                                                   20


<210> 22045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22045
agaataataa ttttgggtac                                                   20


<210> 22046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22046
caaaagagaa taataatttt                                                   20


<210> 22047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22047
acaaaagaga ataataattt                                                   20


<210> 22048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22048
taaatggtag aattacaaaa                                                   20


<210> 22049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22049
actaaatggt agaattacaa                                                   20


<210> 22050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22050
gatctttgga gactaaatgg                                                   20


<210> 22051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22051
agagatcttt ggagactaaa                                                   20


<210> 22052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22052
tatacaaaaa gagatctttg                                                   20


<210> 22053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22053
cctatacaaa aagagatctt                                                   20


<210> 22054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22054
tggtaccacc tatacaaaaa                                                   20


<210> 22055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22055
tgtggtacca cctatacaaa                                                   20


<210> 22056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22056
taactgagat actctggttg                                                   20


<210> 22057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22057
gtcaactaac tgagatactc                                                   20


<210> 22058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22058
gagtttcttg tcaactaact                                                   20


<210> 22059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22059
gataaaggag tctaattctg                                                   20


<210> 22060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22060
gagataaagg agtctaattc                                                   20


<210> 22061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22061
gtgatttgca agagataaag                                                   20


<210> 22062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22062
ttgtgatttg caagagataa                                                   20


<210> 22063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22063
cttgtgattt gcaagagata                                                   20


<210> 22064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22064
gtattgcttg tgatttgcaa                                                   20


<210> 22065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22065
cagtattgct tgtgatttgc                                                   20


<210> 22066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22066
attttagagg gtagaatcta                                                   20


<210> 22067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22067
cattaaaaca ttttagaggg                                                   20


<210> 22068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22068
ttccattaaa acattttaga                                                   20


<210> 22069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22069
gttccattaa aacattttag                                                   20


<210> 22070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22070
tgttccatta aaacatttta                                                   20


<210> 22071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22071
tatgttccat taaaacattt                                                   20


<210> 22072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22072
cctgtgtgtc aatggagaat                                                   20


<210> 22073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22073
tcctgtgtgt caatggagaa                                                   20


<210> 22074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22074
attagtcctg tgtgtcaatg                                                   20


<210> 22075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22075
aaattagtcc tgtgtgtcaa                                                   20


<210> 22076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22076
accacactaa gtctccaaat                                                   20


<210> 22077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22077
cctgccacct ggaccacact                                                   20


<210> 22078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22078
accctgcttg acctgccacc                                                   20


<210> 22079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22079
ggaaggacca aagactattt                                                   20


<210> 22080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22080
aaatgactag ggaaggacca                                                   20


<210> 22081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22081
atgcacaaaa tgactaggga                                                   20


<210> 22082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22082
gatgcacaaa atgactaggg                                                   20


<210> 22083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22083
agtgatgcac aaaatgacta                                                   20


<210> 22084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22084
cagtgatgca caaaatgact                                                   20


<210> 22085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22085
gcagtgatgc acaaaatgac                                                   20


<210> 22086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22086
tttacaaaaa attaatctag                                                   20


<210> 22087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22087
agctttacaa aaaattaatc                                                   20


<210> 22088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22088
aattgctttt tctagagact                                                   20


<210> 22089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22089
ctccagaatt gctttttcta                                                   20


<210> 22090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22090
agctccagaa ttgctttttc                                                   20


<210> 22091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22091
tttcattatg gatctagctc                                                   20


<210> 22092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22092
aagtagtttc attatggatc                                                   20


<210> 22093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22093
gctaaaaagt agtttcatta                                                   20


<210> 22094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22094
atggcctgac agctaaaaag                                                   20


<210> 22095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22095
cacatggcct gacagctaaa                                                   20


<210> 22096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22096
cttatttgca catggcctga                                                   20


<210> 22097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22097
aaaattatct tatttgcaca                                                   20


<210> 22098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22098
agtatcctca tttaacctct                                                   20


<210> 22099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22099
tacaacaaat ctaaaagaca                                                   20


<210> 22100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22100
aaattttaca acaaatctaa                                                   20


<210> 22101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22101
aaatacttct aacataattg                                                   20


<210> 22102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22102
attaagactc catgatatgt                                                   20


<210> 22103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22103
gcaggagatt gatgtttatt                                                   20


<210> 22104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22104
agggaagaat atggaagcag                                                   20


<210> 22105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22105
gtagggaaga atatggaagc                                                   20


<210> 22106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22106
agtagggaag aatatggaag                                                   20


<210> 22107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22107
ttgagtaggg aagaatatgg                                                   20


<210> 22108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22108
atgttgagta gggaagaata                                                   20


<210> 22109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22109
ttcatatatg ttgagtaggg                                                   20


<210> 22110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22110
tcattcatat atgttgagta                                                   20


<210> 22111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22111
ttcattcata tatgttgagt                                                   20


<210> 22112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22112
tttcattcat atatgttgag                                                   20


<210> 22113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22113
gtgtttcatt catatatgtt                                                   20


<210> 22114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22114
agaccttttt taatagcagc                                                   20


<210> 22115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22115
tattagacct tttttaatag                                                   20


<210> 22116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22116
ccgtattaga ccttttttaa                                                   20


<210> 22117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22117
gtagatataa aaagccgtat                                                   20


<210> 22118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22118
tgcctgagag tagatataaa                                                   20


<210> 22119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22119
ggttttaacc tgcctgagag                                                   20


<210> 22120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22120
tgaggtttta acctgcctga                                                   20


<210> 22121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22121
gatgaggttt taacctgcct                                                   20


<210> 22122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22122
tggagaaata gtaaaagatg                                                   20


<210> 22123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22123
ttggagaaat agtaaaagat                                                   20


<210> 22124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22124
aagatttgga gaaatagtaa                                                   20


<210> 22125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22125
aaatttaaga tttggagaaa                                                   20


<210> 22126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22126
ttgaagaaat ttaagatttg                                                   20


<210> 22127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22127
ttttgaagaa atttaagatt                                                   20


<210> 22128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22128
tttcggtttt gaagaaattt                                                   20


<210> 22129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22129
tagcaatgct ttcggttttg                                                   20


<210> 22130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 22130
aggggggata gcaatgcttt                                                   20


<210> 22131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22131
aggcagcaat tcagggggga                                                   20


<210> 22132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22132
aaagaggcag caattcaggg                                                   20


<210> 22133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22133
aaaagaggca gcaattcagg                                                   20


<210> 22134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22134
taaaagaggc agcaattcag                                                   20


<210> 22135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22135
ataaaagagg cagcaattca                                                   20


<210> 22136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22136
gataaaagag gcagcaattc                                                   20


<210> 22137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22137
tgataaaaga ggcagcaatt                                                   20


<210> 22138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22138
aattgtgttg ataaaagagg                                                   20


<210> 22139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22139
atgaattgtg ttgataaaag                                                   20


<210> 22140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22140
aatgaattgt gttgataaaa                                                   20


<210> 22141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22141
caaatgaatt gtgttgataa                                                   20


<210> 22142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22142
ggagtgaaac agaaatgaat                                                   20


<210> 22143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22143
ctaacccaca tggagtgaaa                                                   20


<210> 22144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22144
aagaatggct aacccacatg                                                   20


<210> 22145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22145
aaaagaatgg ctaacccaca                                                   20


<210> 22146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22146
gcaacggaga ggcaaaagaa                                                   20


<210> 22147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22147
atgtagcaac ggagaggcaa                                                   20


<210> 22148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22148
gaagacatgt agcaacggag                                                   20


<210> 22149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22149
agaagacatg tagcaacgga                                                   20


<210> 22150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22150
aaagaagaca tgtagcaacg                                                   20


<210> 22151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 22151
ggaaagaaga catgtagcaa                                                   20


<210> 22152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22152
aaggtgggaa agaagacatg                                                   20


<210> 22153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22153
ggctttggaa ggtgggaaag                                                   20


<210> 22154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22154
gaaggctttg gaaggtggga                                                   20


<210> 22155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22155
ttgagaaggc tttggaaggt                                                   20


<210> 22156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22156
attgagaagg ctttggaagg                                                   20


<210> 22157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22157
acaattgaga aggctttgga                                                   20


<210> 22158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22158
gacaattgag aaggctttgg                                                   20


<210> 22159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22159
cgtgacaatt gagaaggctt                                                   20


<210> 22160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22160
gaaatacgtg acaattgaga                                                   20


<210> 22161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22161
tgaaatacgt gacaattgag                                                   20


<210> 22162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22162
ttatgaaata cgtgacaatt                                                   20


<210> 22163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22163
aaatagatgc tgctatagaa                                                   20


<210> 22164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22164
agtaaaaata gatgctgcta                                                   20


<210> 22165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22165
catgacagtc agagtaaaaa                                                   20


<210> 22166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22166
aaaaatatac atgacagtca                                                   20


<210> 22167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22167
caaaaaatat acatgacagt                                                   20


<210> 22168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22168
agcacaaaaa atatacatga                                                   20


<210> 22169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22169
atacaataag aaaaattaac                                                   20


<210> 22170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22170
ataatcatga taaatacaat                                                   20


<210> 22171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22171
tgaaggttag atagagtcag                                                   20


<210> 22172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22172
tgatgaaggt tagatagagt                                                   20


<210> 22173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22173
tatgtgatga aggttagata                                                   20


<210> 22174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22174
agtatgtgat gaaggttaga                                                   20


<210> 22175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22175
atcgagtatg tgatgaaggt                                                   20


<210> 22176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22176
atatatcgag tatgtgatga                                                   20


<210> 22177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22177
catatatcga gtatgtgatg                                                   20


<210> 22178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22178
cttacccaag gtcatatatc                                                   20


<210> 22179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22179
gaggttaagt gacttaccca                                                   20


<210> 22180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22180
agaggttaag tgacttaccc                                                   20


<210> 22181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22181
aggaaaggca cacagaggtt                                                   20


<210> 22182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22182
aaatgaggaa aggcacacag                                                   20


<210> 22183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22183
caaatgagga aaggcacaca                                                   20


<210> 22184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22184
cacaaatgag gaaaggcaca                                                   20


<210> 22185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22185
tctctttcac aaatgaggaa                                                   20


<210> 22186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22186
gtctctttca caaatgagga                                                   20


<210> 22187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22187
cagagtctct ttcacaaatg                                                   20


<210> 22188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22188
acagagtctc tttcacaaat                                                   20


<210> 22189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22189
atcacaaaag tattattaca                                                   20


<210> 22190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22190
caatcacaaa agtattatta                                                   20


<210> 22191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22191
acccataaca tcaatcacaa                                                   20


<210> 22192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22192
gacttatatg taccttctta                                                   20


<210> 22193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22193
ggacttatat gtaccttctt                                                   20


<210> 22194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22194
aggacttata tgtaccttct                                                   20


<210> 22195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22195
attctgaagt gctaagggtt                                                   20


<210> 22196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22196
cattctgaag tgctaagggt                                                   20


<210> 22197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22197
gtcacattct gaagtgctaa                                                   20


<210> 22198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22198
ggtcacattc tgaagtgcta                                                   20


<210> 22199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22199
aggtcacatt ctgaagtgct                                                   20


<210> 22200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22200
tcaaataagg tcacattctg                                                   20


<210> 22201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22201
aatgacatta ttttcaaata                                                   20


<210> 22202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22202
caatgacatt attttcaaat                                                   20


<210> 22203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22203
attaagagcc cactccactc                                                   20


<210> 22204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22204
tgccagtcac actggattaa                                                   20


<210> 22205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22205
gatgccagtc acactggatt                                                   20


<210> 22206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22206
agtaaggatg ccagtcacac                                                   20


<210> 22207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22207
tcctctacta gtaaggatgc                                                   20


<210> 22208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22208
gtctttctcc tctactagta                                                   20


<210> 22209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22209
tgtctttctc ctctactagt                                                   20


<210> 22210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22210
tgtgtgtctt tctcctctac                                                   20


<210> 22211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22211
aactccaatc tctcccatta                                                   20


<210> 22212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22212
tgtttcttgg tttatggcaa                                                   20


<210> 22213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22213
cccaggtgtt tcttggttta                                                   20


<210> 22214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22214
ctggtagccc aggtgtttct                                                   20


<210> 22215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22215
cttccagctt ctggtagccc                                                   20


<210> 22216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22216
tcttccagct tctggtagcc                                                   20


<210> 22217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22217
ttgcctcttc cagcttctgg                                                   20


<210> 22218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22218
ttattgcctc ttccagcttc                                                   20


<210> 22219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22219
atatatttta ttgcctcttc                                                   20


<210> 22220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22220
atgttctctt taaagcctct                                                   20


<210> 22221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22221
gcaggtccat gttctcttta                                                   20


<210> 22222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22222
tccaaattca aagtgtcagc                                                   20


<210> 22223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22223
gtccaaattc aaagtgtcag                                                   20


<210> 22224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22224
gaagtccaaa ttcaaagtgt                                                   20


<210> 22225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22225
aggttagaag tccaaattca                                                   20


<210> 22226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22226
ctcacacttt tggaggttag                                                   20


<210> 22227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22227
tctctcacac ttttggaggt                                                   20


<210> 22228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22228
atattctctc acacttttgg                                                   20


<210> 22229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22229
tatattctct cacacttttg                                                   20


<210> 22230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22230
aatatattct ctcacacttt                                                   20


<210> 22231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22231
aacctgaggg cttaaaacaa                                                   20


<210> 22232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22232
caaacctgag ggcttaaaac                                                   20


<210> 22233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22233
acaggataat acaaacctga                                                   20


<210> 22234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22234
aacaggataa tacaaacctg                                                   20


<210> 22235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22235
gaacaggata atacaaacct                                                   20


<210> 22236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22236
tttctttgac ctacgagaac                                                   20


<210> 22237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22237
gtttctttga cctacgagaa                                                   20


<210> 22238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22238
tattagtttc tttgacctac                                                   20


<210> 22239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22239
aatcttcaca tcaactgtat                                                   20


<210> 22240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22240
cttgttgaat actgtaattt                                                   20


<210> 22241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22241
taacacaggt aatgaaaatt                                                   20


<210> 22242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22242
catagcagaa taaataacac                                                   20


<210> 22243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22243
tcatagcaga ataaataaca                                                   20


<210> 22244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22244
tcaaggagtt tatgtcatag                                                   20


<210> 22245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22245
agctcaagga gtttatgtca                                                   20


<210> 22246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22246
atatggttcc tgagctcaag                                                   20


<210> 22247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22247
agatatggtt cctgagctca                                                   20


<210> 22248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22248
aagatatggt tcctgagctc                                                   20


<210> 22249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22249
caacgtaaga tatggttcct                                                   20


<210> 22250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22250
ggggagacca acgtaagata                                                   20


<210> 22251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22251
gagcttgggg agaccaacgt                                                   20


<210> 22252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22252
atattgggtt ggagcttggg                                                   20


<210> 22253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22253
atatattggg ttggagcttg                                                   20


<210> 22254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22254
tatatattgg gttggagctt                                                   20


<210> 22255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22255
atatatattg ggttggagct                                                   20


<210> 22256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22256
gtgtaatata tattgggttg                                                   20


<210> 22257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22257
ttgtgtaata tatattgggt                                                   20


<210> 22258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22258
tattttgtgt aatatatatt                                                   20


<210> 22259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22259
ttattttgtg taatatatat                                                   20


<210> 22260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22260
ttcaaaacac attttataag                                                   20


<210> 22261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22261
ttattcaaaa cacattttat                                                   20


<210> 22262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22262
ctatagagga ttgaataatt                                                   20


<210> 22263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22263
ttttccaatg tttcctatag                                                   20


<210> 22264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22264
tttttccaat gtttcctata                                                   20


<210> 22265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22265
gttttttcca atgtttccta                                                   20


<210> 22266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22266
aggttaaacc cataggtttt                                                   20


<210> 22267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22267
atgatttagg ttaaacccat                                                   20


<210> 22268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22268
tatgatttag gttaaaccca                                                   20


<210> 22269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22269
ttctggctaa cttatgattt                                                   20


<210> 22270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22270
gttctggcta acttatgatt                                                   20


<210> 22271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22271
attttctaaa taataggttc                                                   20


<210> 22272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22272
aaaacaattt tctaaataat                                                   20


<210> 22273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22273
gaaaacaatt ttctaaataa                                                   20


<210> 22274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22274
taatcttatt catttttgca                                                   20


<210> 22275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22275
ttatttttca aataattgac                                                   20


<210> 22276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22276
caattcatga ttaattttat                                                   20


<210> 22277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22277
tttccaaaaa agataatgta                                                   20


<210> 22278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22278
tgaacaatta ttttccaaaa                                                   20


<210> 22279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22279
tatttttcat tgtaatgaaa                                                   20


<210> 22280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22280
atatttttca ttgtaatgaa                                                   20


<210> 22281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22281
aatatttttc attgtaatga                                                   20


<210> 22282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22282
aaccaacaga aaaagaagat                                                   20


<210> 22283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22283
atttcaacca acagaaaaag                                                   20


<210> 22284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22284
ataatttcaa ccaacagaaa                                                   20


<210> 22285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22285
tcatagataa tttcaaccaa                                                   20


<210> 22286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22286
cttgttcatt ggtgtcatca                                                   20


<210> 22287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22287
ttcactttga acttgttcat                                                   20


<210> 22288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22288
ttgtcgtctt tatcatcttt                                                   20


<210> 22289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22289
tttgtcgtct ttatcatctt                                                   20


<210> 22290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22290
aagcagccca aatatgaata                                                   20


<210> 22291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22291
aaattttata ggtagacaag                                                   20


<210> 22292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22292
tgtaaatttt ataggtagac                                                   20


<210> 22293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22293
acttttgtaa attttatagg                                                   20


<210> 22294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22294
ctaacttttg taaattttat                                                   20


<210> 22295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22295
gctaactttt gtaaatttta                                                   20


<210> 22296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22296
cctggtcaaa ccatgtgaaa                                                   20


<210> 22297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22297
atagcactgt ttgaattacc                                                   20


<210> 22298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22298
aatcctatgt ttacctagga                                                   20


<210> 22299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22299
cttaaatcct atgtttacct                                                   20


<210> 22300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22300
tcttaaatcc tatgtttacc                                                   20


<210> 22301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22301
gttaaacctc aacaatgcta                                                   20


<210> 22302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22302
catgttgaat aaattgttaa                                                   20


<210> 22303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22303
tacatgttga ataaattgtt                                                   20


<210> 22304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22304
tatgtaataa attaaataat                                                   20


<210> 22305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22305
gattatatta tttattacat                                                   20


<210> 22306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22306
aagccctttg tagttatttg                                                   20


<210> 22307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22307
gcatatgatt aagccctttg                                                   20


<210> 22308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22308
gcacaaatat gcatatgatt                                                   20


<210> 22309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22309
ttgaattttc ctaccaatat                                                   20


<210> 22310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22310
catatacata gtatgtcact                                                   20


<210> 22311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22311
ttttggaaat aacatataca                                                   20


<210> 22312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22312
tgtctcattt acagtacttt                                                   20


<210> 22313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22313
atatgataat gtctcattta                                                   20


<210> 22314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22314
cggaatcaaa agaaaataca                                                   20


<210> 22315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22315
aaagatgtat tcggaatcaa                                                   20


<210> 22316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 22316
aaatataata aagatgtatt                                                   20


<210> 22317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22317
tatttttaca aaatataata                                                   20


<210> 22318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22318
aactttaatg attactccct                                                   20


<210> 22319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22319
aaactttaat gattactccc                                                   20


<210> 22320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22320
tgtgaaataa gttccatgct                                                   20


<210> 22321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22321
tggatgagtt tatgtgaaat                                                   20


<210> 22322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22322
cagtttaaaa caccttggat                                                   20


<210> 22323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22323
ttttacagtt taaaacacct                                                   20


<210> 22324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22324
tatagctttt actgttttta                                                   20


<210> 22325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22325
aataaaataa ttttaatgta                                                   20


<210> 22326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22326
ggctggcatt actaaatgct                                                   20


<210> 22327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22327
gcagggcact tagtgcaggc                                                   20


<210> 22328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22328
agaagcaggg cacttagtgc                                                   20


<210> 22329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22329
tagaagcagg gcacttagtg                                                   20


<210> 22330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22330
gaaaatagaa gcagggcact                                                   20


<210> 22331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22331
ccaacaagaa aatagaagca                                                   20


<210> 22332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22332
cccaacaaga aaatagaagc                                                   20


<210> 22333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22333
acccaacaag aaaatagaag                                                   20


<210> 22334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22334
aggacccaac aagaaaatag                                                   20


<210> 22335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22335
gtgaggaccc aacaagaaaa                                                   20


<210> 22336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22336
tagtgttgtg aggacccaac                                                   20


<210> 22337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22337
gcctactcca tagtgttgtg                                                   20


<210> 22338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22338
tgcctactcc atagtgttgt                                                   20


<210> 22339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22339
atcatccaat gcctactcca                                                   20


<210> 22340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22340
taccttacct tcttgagact                                                   20


<210> 22341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22341
gcaaattacc ttaccttctt                                                   20


<210> 22342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22342
caagctctac aactgacttc                                                   20


<210> 22343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 22343
ccaagctcta caactgactt                                                   20


<210> 22344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22344
ctagctgtac catatcatcc                                                   20


<210> 22345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22345
atagagcctg attcaaattc                                                   20


<210> 22346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22346
gagtacagca gttggagata                                                   20


<210> 22347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22347
gtgagtacag cagttggaga                                                   20


<210> 22348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22348
ggttgtgagt acagcagttg                                                   20


<210> 22349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22349
gtggttgtga gtacagcagt                                                   20


<210> 22350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22350
cctagtggtt gtgagtacag                                                   20


<210> 22351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22351
tagcctagtg gttgtgagta                                                   20


<210> 22352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22352
gatagtagcc tagtggttgt                                                   20


<210> 22353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22353
tccacctgat agtagcctag                                                   20


<210> 22354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22354
acatccacct gatagtagcc                                                   20


<210> 22355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22355
gaagaacatc cacctgatag                                                   20


<210> 22356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22356
aatgaagaac atccacctga                                                   20


<210> 22357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22357
tgggactcac atagacaatg                                                   20


<210> 22358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22358
tgaagccctt gggactcaca                                                   20


<210> 22359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22359
tataacttca tgaagccctt                                                   20


<210> 22360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22360
ctataacttc atgaagccct                                                   20


<210> 22361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22361
ttccaaacta taacttcatg                                                   20


<210> 22362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22362
aaaagcttct tagtttattt                                                   20


<210> 22363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22363
ctttattttt aaaagcttct                                                   20


<210> 22364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22364
gcactaaact ttatttttaa                                                   20


<210> 22365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22365
aatgtaagta ttgattatct                                                   20


<210> 22366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22366
gcagtggatt ctgttaatgt                                                   20


<210> 22367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22367
gattattatg tatgcagcag                                                   20


<210> 22368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22368
gacgattatt atgtatgcag                                                   20


<210> 22369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22369
atggacgatt attatgtatg                                                   20


<210> 22370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22370
taaaggcaac ttttaaggga                                                   20


<210> 22371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22371
ttcttaaagg caacttttaa                                                   20


<210> 22372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22372
attcttaaag gcaactttta                                                   20


<210> 22373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22373
tattcttaaa ggcaactttt                                                   20


<210> 22374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22374
tctattaatg ttattcttaa                                                   20


<210> 22375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22375
ttctattaat gttattctta                                                   20


<210> 22376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22376
ttatggctat tttagaatat                                                   20


<210> 22377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22377
aactctgttt atggctattt                                                   20


<210> 22378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22378
aacagacaaa actctgttta                                                   20


<210> 22379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22379
ataattgtgg taacattaaa                                                   20


<210> 22380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22380
ctagtattac ttaataattg                                                   20


<210> 22381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22381
ttgaatacag caaaacttac                                                   20


<210> 22382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22382
ttaaatggac atgttgaata                                                   20


<210> 22383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22383
aaaaaaatct ttacattaaa                                                   20


<210> 22384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22384
taagatttag aatgttactt                                                   20


<210> 22385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22385
ctaagattta gaatgttact                                                   20


<210> 22386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22386
aattaactgg gactaagatt                                                   20


<210> 22387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22387
agaaataatt aactgggact                                                   20


<210> 22388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22388
caatttagaa ataattaact                                                   20


<210> 22389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22389
acaatttaga aataattaac                                                   20


<210> 22390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22390
cacaggcaac tgtaacaatt                                                   20


<210> 22391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22391
aggttatgtg cgaaattcac                                                   20


<210> 22392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22392
aaggttatgt gcgaaattca                                                   20


<210> 22393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22393
cttcaccttt aaaaaataaa                                                   20


<210> 22394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22394
ccttcacctt taaaaaataa                                                   20


<210> 22395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22395
accctttaaa aaatggagaa                                                   20


<210> 22396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22396
ggagaaccct ttaaaaaatg                                                   20


<210> 22397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22397
atggagaacc ctttaaaaaa                                                   20


<210> 22398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22398
aggaacttcc cacaggcatg                                                   20


<210> 22399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22399
agaggaactt cccacaggca                                                   20


<210> 22400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22400
ggatgagagg aacttcccac                                                   20


<210> 22401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22401
gggatgagag gaacttccca                                                   20


<210> 22402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22402
tcacactatg aagggatgag                                                   20


<210> 22403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22403
ttcacactat gaagggatga                                                   20


<210> 22404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22404
gcttcacact atgaagggat                                                   20


<210> 22405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22405
ttcctgcttc acactatgaa                                                   20


<210> 22406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22406
cttcctgctt cacactatga                                                   20


<210> 22407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22407
acttcctgct tcacactatg                                                   20


<210> 22408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22408
attgactctt tggtgtcatg                                                   20


<210> 22409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22409
ttaatttata attgactctt                                                   20


<210> 22410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22410
gcatgggttc tgttgcattt                                                   20


<210> 22411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22411
cctacatgaa taagaagcat                                                   20


<210> 22412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22412
tcctacatga ataagaagca                                                   20


<210> 22413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22413
catgttccta catgaataag                                                   20


<210> 22414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22414
gaacatgttc ctacatgaat                                                   20


<210> 22415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22415
aaaaaagtgt tggtctttcc                                                   20


<210> 22416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22416
aaaaaaaaaa aaaaaagtgt                                                   20


<210> 22417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22417
aaaaaaaaaa aaaaaaaaaa                                                   20


<210> 22418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22418
tccagcctgg gctacagagc                                                   20


<210> 22419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22419
gcactccagc ctgggctaca                                                   20


<210> 22420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22420
ctgcactcca gcctgggcta                                                   20


<210> 22421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22421
gtgccactgc actccagcct                                                   20


<210> 22422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22422
cgtgccactg cactccagcc                                                   20


<210> 22423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22423
aagatcgtgc cactgcactc                                                   20


<210> 22424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22424
ggcggaggtt gcagtgggcc                                                   20


<210> 22425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22425
tgggaggcgg aggttgcagt                                                   20


<210> 22426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22426
ctgggaggcg gaggttgcag                                                   20


<210> 22427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22427
aacctgggag gcggaggttg                                                   20


<210> 22428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22428
cacgtgaacc tgggaggcgg                                                   20


<210> 22429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22429
tcacgtgaac ctgggaggcg                                                   20


<210> 22430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 22430
aatcacgtga acctgggagg                                                   20


<210> 22431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22431
gagaatcacg tgaacctggg                                                   20


<210> 22432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22432
ggagaatcac gtgaacctgg                                                   20


<210> 22433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22433
caggagaatc acgtgaacct                                                   20


<210> 22434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22434
gcaggagaat cacgtgaacc                                                   20


<210> 22435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22435
tgcttgggag gctgaggcag                                                   20


<210> 22436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22436
gctgcttggg aggctgaggc                                                   20


<210> 22437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22437
agctgcttgg gaggctgagg                                                   20


<210> 22438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22438
cctagctgct tgggaggctg                                                   20


<210> 22439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22439
tcctagctgc ttgggaggct                                                   20


<210> 22440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22440
tgtaatccta gctgcttggg                                                   20


<210> 22441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22441
ctgtaatcct agctgcttgg                                                   20


<210> 22442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22442
gcctgtaatc ctagctgctt                                                   20


<210> 22443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22443
cgcctgtaat cctagctgct                                                   20


<210> 22444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22444
gtggcaggcg cctgtaatcc                                                   20


<210> 22445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22445
aattagctgg gtgtggtggc                                                   20


<210> 22446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22446
aaattagctg ggtgtggtgg                                                   20


<210> 22447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22447
aaaaaattag ctgggtgtgg                                                   20


<210> 22448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22448
acaaaaaaat tagctgggtg                                                   20


<210> 22449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22449
aaaatacaaa aaaattagct                                                   20


<210> 22450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22450
aaaaatacaa aaaaattagc                                                   20


<210> 22451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22451
tactaaaaat acaaaaaaat                                                   20


<210> 22452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22452
cgagaccagt ctggccaaca                                                   20


<210> 22453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22453
tcaggagttc gagaccagtc                                                   20


<210> 22454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22454
tgaggtcagg agttcgagac                                                   20


<210> 22455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22455
gatcatgagg tcaggagttc                                                   20


<210> 22456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22456
tgggcagatc atgaggtcag                                                   20


<210> 22457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22457
ggtgggcaga tcatgaggtc                                                   20


<210> 22458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22458
aggtgggcag atcatgaggt                                                   20


<210> 22459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22459
gccaaggtgg gcagatcatg                                                   20


<210> 22460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22460
ggccaaggtg ggcagatcat                                                   20


<210> 22461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22461
ctttgggagg ccaaggtggg                                                   20


<210> 22462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22462
tcactttggg aggccaaggt                                                   20


<210> 22463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22463
ttcactttgg gaggccaagg                                                   20


<210> 22464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22464
ctcttcactt tgggaggcca                                                   20


<210> 22465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22465
tctcttcact ttgggaggcc                                                   20


<210> 22466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22466
tgtagtctct tcactttggg                                                   20


<210> 22467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22467
ctgtagtctc ttcactttgg                                                   20


<210> 22468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22468
gcctgtagtc tcttcacttt                                                   20


<210> 22469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22469
tgcctgtagt ctcttcactt                                                   20


<210> 22470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22470
ggcgcagtgg ctcatgcctg                                                   20


<210> 22471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22471
ccagtcttgg ccgggcgcag                                                   20


<210> 22472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22472
gtgccagtct tggccgggcg                                                   20


<210> 22473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22473
aaacagtgcc agtcttggcc                                                   20


<210> 22474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 22474
aaaacagtgc cagtcttggc                                                   20


<210> 22475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22475
ttttaaaaca gtgccagtct                                                   20


<210> 22476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22476
tgtggttttt aaaacagtgc                                                   20


<210> 22477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22477
atactgtgtg gtttttaaaa                                                   20


<210> 22478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22478
attgaagata aaatactgtg                                                   20


<210> 22479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22479
agtatattaa ttataaattg                                                   20


<210> 22480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22480
gatataagtt attctttaaa                                                   20


<210> 22481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22481
agatattgga cgaaggatat                                                   20


<210> 22482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22482
ttttaataga tattggacga                                                   20


<210> 22483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22483
attttaatag atattggacg                                                   20


<210> 22484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22484
cttggtattt taatagatat                                                   20


<210> 22485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22485
atgagtgctt ggtattttaa                                                   20


<210> 22486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22486
tgtcccattt catgagtgct                                                   20


<210> 22487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22487
ttgtaagtgt cccatttcat                                                   20


<210> 22488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22488
ctatctctgc ttcaagttgt                                                   20


<210> 22489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22489
tggttaccta tctctgcttc                                                   20


<210> 22490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22490
aactttgata atgtcggact                                                   20


<210> 22491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 22491
aaagtgaact ttgataatgt                                                   20


<210> 22492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22492
tgtgcgatgg aaaaacctga                                                   20


<210> 22493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22493
atgttagtca aaatgtgcga                                                   20


<210> 22494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22494
tgttttgccc ttatgaatgt                                                   20


<210> 22495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22495
gtcacggttt cctgcaagtc                                                   20


<210> 22496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22496
gatgggtcac ggtttcctgc                                                   20


<210> 22497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 22497
ttaacaccac agatgggtca                                                   20


<210> 22498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22498
agtgtattaa caccacagat                                                   20


<210> 22499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22499
gagtgtatta acaccacaga                                                   20


<210> 22500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22500
ctatgagtgt attaacacca                                                   20


<210> 22501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22501
tgtttgctgg caagttctat                                                   20


<210> 22502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22502
gagtaaattt gtttgctggc                                                   20


<210> 22503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22503
atgggagtaa atttgtttgc                                                   20


<210> 22504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22504
gctgatattc agcatcatgg                                                   20


<210> 22505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22505
tggctgatat tcagcatcat                                                   20


<210> 22506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22506
ctggctgata ttcagcatca                                                   20


<210> 22507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22507
cttatattct ggctgatatt                                                   20


<210> 22508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22508
tacttgtgtg tcttatattc                                                   20


<210> 22509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22509
cgttgtgaat gcactcatag                                                   20


<210> 22510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22510
gtcgttgtga atgcactcat                                                   20


<210> 22511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22511
ggtcgttgtg aatgcactca                                                   20


<210> 22512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22512
ttttctttct tttgaatact                                                   20


<210> 22513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22513
cttttctttc ttttgaatac                                                   20


<210> 22514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22514
ctaatttatt tatgtctgca                                                   20


<210> 22515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 22515
atgtcttaga tatttaaggg                                                   20


<210> 22516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22516
ttgatgtctt agatatttaa                                                   20


<210> 22517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22517
tttgatgtct tagatattta                                                   20


<210> 22518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22518
gtttgatgtc ttagatattt                                                   20


<210> 22519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22519
ggctggttgg tttgatgtct                                                   20


<210> 22520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22520
ataaacatga gtcggctggt                                                   20


<210> 22521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22521
tttaataaac atgagtcggc                                                   20


<210> 22522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 22522
ggcatttaat aaacatgagt                                                   20


<210> 22523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22523
agtaggcatt taataaacat                                                   20


<210> 22524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22524
cacactgctg agtgtagagt                                                   20


<210> 22525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22525
gcacactgct gagtgtagag                                                   20


<210> 22526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22526
ttggcacact gctgagtgta                                                   20


<210> 22527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22527
gcttggcaca ctgctgagtg                                                   20


<210> 22528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22528
gtcttgcttg gcacactgct                                                   20


<210> 22529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22529
atgtcttatt ttgtcttgct                                                   20


<210> 22530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22530
ttgtaagcct ggtgatcaca                                                   20


<210> 22531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22531
atttgtaagc ctggtgatca                                                   20


<210> 22532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22532
aatcatgtaa tttgtaagcc                                                   20


<210> 22533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22533
gtgataatca tgtaatttgt                                                   20


<210> 22534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22534
tttaagctat tatattatct                                                   20


<210> 22535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22535
tatttatttt acatttattt                                                   20


<210> 22536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22536
accttatcaa taacaggttt                                                   20


<210> 22537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22537
aagtttacct tatcaataac                                                   20


<210> 22538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22538
caagtttacc ttatcaataa                                                   20


<210> 22539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22539
ccagagtgta cagattttac                                                   20


<210> 22540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22540
tctttttttt ccagagtgta                                                   20


<210> 22541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22541
atacatttct tttttttcca                                                   20


<210> 22542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22542
ttatacattt cttttttttc                                                   20


<210> 22543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22543
tctttaatgc tggtaataat                                                   20


<210> 22544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22544
atctttaatg ctggtaataa                                                   20


<210> 22545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22545
tatgggggaa tctttaatgc                                                   20


<210> 22546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22546
caccaatagt ttctctatgg                                                   20


<210> 22547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22547
acaccaatag tttctctatg                                                   20


<210> 22548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22548
tacaccaata gtttctctat                                                   20


<210> 22549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22549
atacaccaat agtttctcta                                                   20


<210> 22550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22550
acctacctga tatacaccaa                                                   20


<210> 22551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22551
aattaaatta aaatgatgtc                                                   20


<210> 22552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22552
tcaaaaaaag agaataagaa                                                   20


<210> 22553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22553
atgtctcaaa aaaagagaat                                                   20


<210> 22554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22554
tggagaatgt ctcaaaaaaa                                                   20


<210> 22555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22555
tgtggagaat gtctcaaaaa                                                   20


<210> 22556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22556
agattctcaa tccttttgtg                                                   20


<210> 22557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22557
aaagattctc aatccttttg                                                   20


<210> 22558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22558
taaaggattt aaaccattta                                                   20


<210> 22559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22559
gtagaaccag ccaaatctaa                                                   20


<210> 22560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22560
cgtagaacca gccaaatcta                                                   20


<210> 22561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22561
ttgctcttat ttcgtagaac                                                   20


<210> 22562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22562
aaacgattgc tcttatttcg                                                   20


<210> 22563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22563
gcttacatat aaagtattta                                                   20


<210> 22564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22564
aggcttacat ataaagtatt                                                   20


<210> 22565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22565
tagtcaaagg cttacatata                                                   20


<210> 22566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22566
cactatatat atttagtcaa                                                   20


<210> 22567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22567
gcactatata tatttagtca                                                   20


<210> 22568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22568
aggccagcac tatatatatt                                                   20


<210> 22569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22569
atttttgtct taactgaggc                                                   20


<210> 22570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22570
cctaattttt gtcttaactg                                                   20


<210> 22571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22571
tcctaatttt tgtcttaact                                                   20


<210> 22572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22572
cagaaataaa gaaaggatta                                                   20


<210> 22573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22573
tgaaaagcag aaataaagaa                                                   20


<210> 22574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22574
ctgaaaagca gaaataaaga                                                   20


<210> 22575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22575
aatgctgaaa agcagaaata                                                   20


<210> 22576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22576
gcagtacaaa tgctgaaaag                                                   20


<210> 22577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22577
atagcagtac aaatgctgaa                                                   20


<210> 22578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22578
gacaaactgg tgatcaatag                                                   20


<210> 22579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22579
aaagacaaac tggtgatcaa                                                   20


<210> 22580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22580
ctggagtggc aaagacaaac                                                   20


<210> 22581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22581
ggatgaaaac tggagtggca                                                   20


<210> 22582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22582
gccctggatg aaaactggag                                                   20


<210> 22583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22583
attgccctgg atgaaaactg                                                   20


<210> 22584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22584
gaattgccct ggatgaaaac                                                   20


<210> 22585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22585
aaatgccaca ggaattgccc                                                   20


<210> 22586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22586
tggagagtgt taaatgccac                                                   20


<210> 22587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22587
ctggagagtg ttaaatgcca                                                   20


<210> 22588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22588
agtaaataag aaaatctgga                                                   20


<210> 22589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22589
taagtaaata agaaaatctg                                                   20


<210> 22590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22590
attaagtaaa taagaaaatc                                                   20


<210> 22591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22591
ttttgaaaga ttaagtaaat                                                   20


<210> 22592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22592
caggtaggtt ttgaaagatt                                                   20


<210> 22593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22593
agatgacagg taggttttga                                                   20


<210> 22594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22594
tgaagtgtaa gatgacaggt                                                   20


<210> 22595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22595
ctgaagtgta agatgacagg                                                   20


<210> 22596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22596
aagctgaagt gtaagatgac                                                   20


<210> 22597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22597
caagctgaag tgtaagatga                                                   20


<210> 22598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22598
gggtgctcaa gctgaagtgt                                                   20


<210> 22599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22599
ttgaatgggt gctcaagctg                                                   20


<210> 22600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22600
ttgtacttga atgggtgctc                                                   20


<210> 22601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22601
taacacattt gtacttgaat                                                   20


<210> 22602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22602
ttaacacatt tgtacttgaa                                                   20


<210> 22603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22603
cccagtgctc cttccctaac                                                   20


<210> 22604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22604
tcccagtgct ccttccctaa                                                   20


<210> 22605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22605
attgcagaaa agaaggatcc                                                   20


<210> 22606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22606
ttaatacatt gcagaaaaga                                                   20


<210> 22607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22607
cttaatacat tgcagaaaag                                                   20


<210> 22608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22608
ctgcttaata cattgcagaa                                                   20


<210> 22609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22609
agaacctgct taatacattg                                                   20


<210> 22610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22610
tctctatttt aaagcatctt                                                   20


<210> 22611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22611
cttagtattt ctctatttta                                                   20


<210> 22612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22612
gattagtagt cagagatcct                                                   20


<210> 22613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22613
gatgatctga ttagtagtca                                                   20


<210> 22614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22614
tagatgatct gattagtagt                                                   20


<210> 22615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22615
tccctagatg atctgattag                                                   20


<210> 22616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22616
ttctccctag atgatctgat                                                   20


<210> 22617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22617
atgtttgcaa accttctccc                                                   20


<210> 22618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22618
caacggagat ataacccaca                                                   20


<210> 22619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22619
agagttgaat agttgcaacg                                                   20


<210> 22620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 22620
gcagagttga atagttgcaa                                                   20


<210> 22621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22621
actaccatgg cagagttgaa                                                   20


<210> 22622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22622
gacccatgac taccatggca                                                   20


<210> 22623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22623
atgacccatg actaccatgg                                                   20


<210> 22624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22624
tgtatgaccc atgactacca                                                   20


<210> 22625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22625
ttcttggaac acagccatac                                                   20


<210> 22626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22626
gtaaaaatgt tcttggaaca                                                   20


<210> 22627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22627
tgtttttgta aaaatgttct                                                   20


<210> 22628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22628
gaccaaaggt caacaaaccc                                                   20


<210> 22629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22629
taatcattgc tctggaccaa                                                   20


<210> 22630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22630
ataatcattg ctctggacca                                                   20


<210> 22631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22631
actccaaata atcattgctc                                                   20


<210> 22632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22632
tgcccccagg aaacctctac                                                   20


<210> 22633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22633
atgcccccag gaaacctcta                                                   20


<210> 22634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22634
ttatataatt tcatgccccc                                                   20


<210> 22635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22635
gttatataat ttcatgcccc                                                   20


<210> 22636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22636
gaattgtctt tccggaaaga                                                   20


<210> 22637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22637
gttagaattg tctttccgga                                                   20


<210> 22638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 22638
gaaagttaga attgtctttc                                                   20


<210> 22639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22639
tgtaagaatc tgatgaaagt                                                   20


<210> 22640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22640
agactgtaag aatctgatga                                                   20


<210> 22641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22641
tttgaggtca catagactgt                                                   20


<210> 22642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22642
taatcttttt tgaggtcaca                                                   20


<210> 22643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22643
attcctccta atcttttttg                                                   20


<210> 22644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22644
tattcctcct aatctttttt                                                   20


<210> 22645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22645
aggtaggctc tattaagagc                                                   20


<210> 22646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22646
gaaaaggtag gctctattaa                                                   20


<210> 22647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22647
atgaaaaggt aggctctatt                                                   20


<210> 22648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22648
ggaaatgagc atgaaaaggt                                                   20


<210> 22649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22649
aggaaatgag catgaaaagg                                                   20


<210> 22650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22650
agcaggaaat gagcatgaaa                                                   20


<210> 22651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22651
cagcaggaaa tgagcatgaa                                                   20


<210> 22652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22652
tagggagggc agcaggaaat                                                   20


<210> 22653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22653
aacatagtag ggagggcagc                                                   20


<210> 22654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22654
aaacatagta gggagggcag                                                   20


<210> 22655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22655
gataaacata gtagggaggg                                                   20


<210> 22656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22656
cgtgataaac atagtaggga                                                   20


<210> 22657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22657
acgtgataaa catagtaggg                                                   20


<210> 22658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22658
tacgtgataa acatagtagg                                                   20


<210> 22659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22659
cctacgtgat aaacatagta                                                   20


<210> 22660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22660
gcctacgtga taaacatagt                                                   20


<210> 22661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22661
tgcctacgtg ataaacatag                                                   20


<210> 22662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22662
gagtgcctac gtgataaaca                                                   20


<210> 22663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22663
gtcagtgact agatgtatca                                                   20


<210> 22664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22664
tggtcagtga ctagatgtat                                                   20


<210> 22665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22665
aggtgtgctt ggtcagtgac                                                   20


<210> 22666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22666
ttgtgcaagg tgtgcttggt                                                   20


<210> 22667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22667
tagattgtgc aaggtgtgct                                                   20


<210> 22668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22668
ggcacagaat agattgtgca                                                   20


<210> 22669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22669
aggcacagaa tagattgtgc                                                   20


<210> 22670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22670
catggtaggg aggcacagaa                                                   20


<210> 22671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22671
taccacatgg tagggaggca                                                   20


<210> 22672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22672
agtgatacca catggtaggg                                                   20


<210> 22673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22673
cagtgatacc acatggtagg                                                   20


<210> 22674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22674
ggcagtgata ccacatggta                                                   20


<210> 22675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22675
aggcagtgat accacatggt                                                   20


<210> 22676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22676
aaggcagtga taccacatgg                                                   20


<210> 22677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22677
ttcaaggcag tgataccaca                                                   20


<210> 22678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22678
aggcagatag gcattcaagg                                                   20


<210> 22679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22679
cataggcaga taggcattca                                                   20


<210> 22680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22680
tcataggcag ataggcattc                                                   20


<210> 22681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22681
gccccaaatc ataggcagat                                                   20


<210> 22682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22682
agccccaaat cataggcaga                                                   20


<210> 22683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22683
agtaagcccc aaatcatagg                                                   20


<210> 22684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22684
aagagtaagc cccaaatcat                                                   20


<210> 22685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22685
gaagagtaag ccccaaatca                                                   20


<210> 22686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22686
acatttcatg actgaagagt                                                   20


<210> 22687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22687
tcagacattt catgactgaa                                                   20


<210> 22688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22688
tttcagacat ttcatgactg                                                   20


<210> 22689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22689
atcacaagga ggtgacattt                                                   20


<210> 22690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22690
tctgggaaga catcacaagg                                                   20


<210> 22691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22691
gtctgggaag acatcacaag                                                   20


<210> 22692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22692
aagtctggga agacatcaca                                                   20


<210> 22693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22693
gaagtctggg aagacatcac                                                   20


<210> 22694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22694
gctatccggg gaagtctggg                                                   20


<210> 22695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22695
gtggctatcc ggggaagtct                                                   20


<210> 22696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22696
agtggctatc cggggaagtc                                                   20


<210> 22697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22697
tagggagtgg ctatccgggg                                                   20


<210> 22698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22698
cagtagggag tggctatccg                                                   20


<210> 22699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22699
acagtaggga gtggctatcc                                                   20


<210> 22700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 22700
tacagtaggg agtggctatc                                                   20


<210> 22701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22701
caggaatata cagtagggag                                                   20


<210> 22702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22702
atacaggaat atacagtagg                                                   20


<210> 22703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22703
tgatacagga atatacagta                                                   20


<210> 22704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22704
atgatacagg aatatacagt                                                   20


<210> 22705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22705
aatgatacag gaatatacag                                                   20


<210> 22706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22706
cataatgata caggaatata                                                   20


<210> 22707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22707
acaagggcac ataatgatac                                                   20


<210> 22708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22708
gacaagggca cataatgata                                                   20


<210> 22709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22709
gttacaagag agacagacaa                                                   20


<210> 22710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22710
ggttacaaga gagacagaca                                                   20


<210> 22711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22711
tggttacaag agagacagac                                                   20


<210> 22712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22712
gtcaatggtt acaagagaga                                                   20


<210> 22713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22713
tagggtcaat ggttacaaga                                                   20


<210> 22714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22714
agtagggtca atggttacaa                                                   20


<210> 22715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22715
tgagtagggt caatggttac                                                   20


<210> 22716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22716
caaagagtga gtagggtcaa                                                   20


<210> 22717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22717
cggtccccaa agagtgagta                                                   20


<210> 22718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22718
ccggtcccca aagagtgagt                                                   20


<210> 22719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22719
cccggtcccc aaagagtgag                                                   20


<210> 22720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22720
gaccccggtc cccaaagagt                                                   20


<210> 22721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22721
catagacccc ggtccccaaa                                                   20


<210> 22722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22722
tacatagacc ccggtcccca                                                   20


<210> 22723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 22723
gtacagtggt acatagaccc                                                   20


<210> 22724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22724
acacagagta cagtggtaca                                                   20


<210> 22725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22725
ataaaaaaca cagagtacag                                                   20


<210> 22726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22726
gatataaaaa acacagagta                                                   20


<210> 22727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22727
gttgtgatat aaaaaacaca                                                   20


<210> 22728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22728
gtgttgtgat ataaaaaaca                                                   20


<210> 22729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22729
ttaaacacca actatgtgtc                                                   20


<210> 22730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22730
tttaaacacc aactatgtgt                                                   20


<210> 22731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22731
ccatcattac tcacattttt                                                   20


<210> 22732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22732
ataggtgcct gtctttctca                                                   20


<210> 22733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22733
caataggtgc ctgtctttct                                                   20


<210> 22734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22734
tggcttctca tcagaccaat                                                   20


<210> 22735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22735
ctggcttctc atcagaccaa                                                   20


<210> 22736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22736
tttcccaact ggcttctcat                                                   20


<210> 22737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22737
ggctctttag ctttcccaac                                                   20


<210> 22738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22738
gtttgagtcc ttaggctctt                                                   20


<210> 22739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22739
gtcagcttgt ttgagtcctt                                                   20


<210> 22740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22740
agtcagcttg tttgagtcct                                                   20


<210> 22741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22741
atattgtagt cagcttgttt                                                   20


<210> 22742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22742
catttgaggc atattgtagt                                                   20


<210> 22743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22743
aatgcatttg aggcatattg                                                   20


<210> 22744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22744
ataatgaaat aatgcatttg                                                   20


<210> 22745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22745
aataatgaaa taatgcattt                                                   20


<210> 22746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22746
atgccgcagg gctattttga                                                   20


<210> 22747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22747
catgccgcag ggctattttg                                                   20


<210> 22748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22748
agacatttat tcatgccgca                                                   20


<210> 22749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22749
gagacattta ttcatgccgc                                                   20


<210> 22750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22750
agagacattt attcatgccg                                                   20


<210> 22751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22751
atttgttaac catgcaaaaa                                                   20


<210> 22752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22752
acatttgtta accatgcaaa                                                   20


<210> 22753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22753
ttgagaggca aatgtctatt                                                   20


<210> 22754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22754
atagtttagt atattttgag                                                   20


<210> 22755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22755
aatagtttag tatattttga                                                   20


<210> 22756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22756
agaatagttt agtatatttt                                                   20


<210> 22757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22757
ttggatgcag gagaatagtt                                                   20


<210> 22758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22758
gtgaattgga tgcaggagaa                                                   20


<210> 22759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22759
tacaggtgaa ttggatgcag                                                   20


<210> 22760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22760
attacaggtg aattggatgc                                                   20


<210> 22761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22761
tattacaggt gaattggatg                                                   20


<210> 22762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22762
tatctgtatt acaggtgaat                                                   20


<210> 22763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22763
ttgttcttta tctgtattac                                                   20


<210> 22764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22764
tttgttcttt atctgtatta                                                   20


<210> 22765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22765
acttccttca gtgattaagc                                                   20


<210> 22766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22766
aaccacttcc ttcagtgatt                                                   20


<210> 22767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22767
ccctacaaaa ccacttcctt                                                   20


<210> 22768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22768
cttaattttt tgagcattaa                                                   20


<210> 22769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22769
tgacattaac ttaatttttt                                                   20


<210> 22770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22770
tttgtgcaga aaggtggtat                                                   20


<210> 22771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22771
tttcattttg tgcagaaagg                                                   20


<210> 22772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22772
aagtttcatt ttgtgcagaa                                                   20


<210> 22773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22773
caagtttcat tttgtgcaga                                                   20


<210> 22774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22774
attacaagtt tcattttgtg                                                   20


<210> 22775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22775
atctacaagt tgaaaattac                                                   20


<210> 22776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22776
ttcaaaaata ttctatctac                                                   20


<210> 22777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22777
gattatacaa aaaagttcat                                                   20


<210> 22778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22778
aagatcatga ttatacaaaa                                                   20


<210> 22779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22779
cggtttccaa gtataaaaga                                                   20


<210> 22780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22780
ataacggttt ccaagtataa                                                   20


<210> 22781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22781
tccagtgtat aacggtttcc                                                   20


<210> 22782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 22782
tttaattatc cagtgtataa                                                   20


<210> 22783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22783
tctctgctat tttaattatc                                                   20


<210> 22784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22784
agtgaacatt agagatcttt                                                   20


<210> 22785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22785
ccagcctcaa gtgaacatta                                                   20


<210> 22786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22786
aaccagcctc aagtgaacat                                                   20


<210> 22787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22787
cttgggtttt aaccagcctc                                                   20


<210> 22788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22788
taagaaactt gggttttaac                                                   20


<210> 22789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22789
aggatgggga taagaaactt                                                   20


<210> 22790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22790
caggatgggg ataagaaact                                                   20


<210> 22791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22791
agaaactcca ggatggggat                                                   20


<210> 22792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22792
gagtcagaaa ctccaggatg                                                   20


<210> 22793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22793
tgagtcagaa actccaggat                                                   20


<210> 22794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22794
ctgagtcaga aactccagga                                                   20


<210> 22795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22795
cctactgagt cagaaactcc                                                   20


<210> 22796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22796
acctactgag tcagaaactc                                                   20


<210> 22797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22797
tcaccccaga cctactgagt                                                   20


<210> 22798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22798
gatctcaccc cagacctact                                                   20


<210> 22799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22799
caaattcttg gatctcaccc                                                   20


<210> 22800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22800
aaaaaaaaaa agcaaattct                                                   20


<210> 22801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22801
caaaaaaaaa aaaaaaaaaa                                                   20


<210> 22802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22802
tccagcctgg ggaacagagc                                                   20


<210> 22803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22803
gcactccagc ctggggaaca                                                   20


<210> 22804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22804
ctgcactcca gcctggggaa                                                   20


<210> 22805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22805
tgcaactgca ctccagcctg                                                   20


<210> 22806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22806
atgcaactgc actccagcct                                                   20


<210> 22807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22807
catgcaactg cactccagcc                                                   20


<210> 22808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22808
gagatcatgc aactgcactc                                                   20


<210> 22809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22809
ggcagaggtt gcagtgagcc                                                   20


<210> 22810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22810
cgggaggcag aggttgcagt                                                   20


<210> 22811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22811
aacccgggag gcagaggttg                                                   20


<210> 22812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22812
cgcttgaacc cgggaggcag                                                   20


<210> 22813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22813
tcgcttgaac ccgggaggca                                                   20


<210> 22814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22814
aatcgcttga acccgggagg                                                   20


<210> 22815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22815
aagaatcgct tgaacccggg                                                   20


<210> 22816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22816
gaagaatcgc ttgaacccgg                                                   20


<210> 22817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22817
cagaagaatc gcttgaaccc                                                   20


<210> 22818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 22818
gcagaagaat cgcttgaacc                                                   20


<210> 22819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22819
tactagggag gctgaggcag                                                   20


<210> 22820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22820
agctactagg gaggctgagg                                                   20


<210> 22821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22821
ctcagctact agggaggctg                                                   20


<210> 22822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22822
tctcagctac tagggaggct                                                   20


<210> 22823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22823
tgtagtctca gctactaggg                                                   20


<210> 22824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22824
ctgtagtctc agctactagg                                                   20


<210> 22825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22825
acctgtagtc tcagctacta                                                   20


<210> 22826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22826
cacctgtagt ctcagctact                                                   20


<210> 22827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22827
tcacctgtag tctcagctac                                                   20


<210> 22828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22828
gtggtgctca cctgtagtct                                                   20


<210> 22829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22829
ggcatagtgg tgctcacctg                                                   20


<210> 22830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22830
aaaaaattac ccgggcatag                                                   20


<210> 22831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22831
tgcaaaaaat tacccgggca                                                   20


<210> 22832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22832
aaaaatgcaa aaaattaccc                                                   20


<210> 22833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 22833
taaaaatgca aaaaattacc                                                   20


<210> 22834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22834
cgagaccagc ctggccaata                                                   20


<210> 22835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22835
tcaggagttc gagaccagcc                                                   20


<210> 22836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22836
tgaggtcagg agttcgagac                                                   20


<210> 22837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22837
gatcatgagg tcaggagttc                                                   20


<210> 22838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22838
cggacggatc atgaggtcag                                                   20


<210> 22839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22839
gacggacgga tcatgaggtc                                                   20


<210> 22840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22840
agacggacgg atcatgaggt                                                   20


<210> 22841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22841
aaaaagacgg acggatcatg                                                   20


<210> 22842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22842
taaaaagacg gacggatcat                                                   20


<210> 22843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 22843
aaacttatta aaaagacgga                                                   20


<210> 22844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 22844
ctacaaactt attaaaaaga                                                   20


<210> 22845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22845
ttatctacaa acttattaaa                                                   20


<210> 22846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22846
gtggtttact gaccagctat                                                   20


<210> 22847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22847
tttaagtgtg gtttactgac                                                   20


<210> 22848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22848
gcttactgat actttaagtg                                                   20


<210> 22849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22849
gtccagctta ctgatacttt                                                   20


<210> 22850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22850
atttaacacg gagattagtc                                                   20


<210> 22851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22851
gagcaattta acacggagat                                                   20


<210> 22852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22852
tctctgagca atttaacacg                                                   20


<210> 22853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 22853
cttctctgag caatttaaca                                                   20


<210> 22854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22854
ctccctacct taccttctct                                                   20


<210> 22855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22855
ctggatattc tctctctgtt                                                   20


<210> 22856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22856
cgtccaccag gagacataac                                                   20


<210> 22857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22857
ttgccttgtc cgtccaccag                                                   20


<210> 22858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22858
agttgccttg tccgtccacc                                                   20


<210> 22859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22859
aagttgcctt gtccgtccac                                                   20


<210> 22860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22860
gtcctttaag gctcaattta                                                   20


<210> 22861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22861
aaacacctat ctgtccttta                                                   20


<210> 22862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22862
caaacaccta tctgtccttt                                                   20


<210> 22863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22863
accctaaccc gtttgtatag                                                   20


<210> 22864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22864
ccgaccctaa cccgtttgta                                                   20


<210> 22865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22865
gctattttat gcctctgttc                                                   20


<210> 22866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22866
ctcctctaaa atttcttctc                                                   20


<210> 22867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22867
tagtccatat cctcatgtgt                                                   20


<210> 22868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22868
acaactctat tttctgtaat                                                   20


<210> 22869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22869
caactttgta acacacatgg                                                   20


<210> 22870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22870
gcaactttgt aacacacatg                                                   20


<210> 22871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22871
cagcaacttt gtaacacaca                                                   20


<210> 22872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22872
ctttaaggat tgtattaaac                                                   20


<210> 22873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22873
actaccataa cctagcttta                                                   20


<210> 22874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22874
aactaccata acctagcttt                                                   20


<210> 22875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22875
gaataacaac taccataacc                                                   20


<210> 22876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22876
ctcaattagc agagacaaac                                                   20


<210> 22877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22877
gaaaagatac tcaattagca                                                   20


<210> 22878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22878
ctgaaaagat actcaattag                                                   20


<210> 22879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22879
tgcctgaaaa gatactcaat                                                   20


<210> 22880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22880
taggctgcag agtgcctgaa                                                   20


<210> 22881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22881
taatttgcac ttaggctgca                                                   20


<210> 22882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22882
cttaatttgc acttaggctg                                                   20


<210> 22883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22883
agtttactta atttgcactt                                                   20


<210> 22884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22884
gagtttactt aatttgcact                                                   20


<210> 22885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22885
tgagaaaact aaagctcaga                                                   20


<210> 22886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22886
tttgagaaaa ctaaagctca                                                   20


<210> 22887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22887
tatttgagaa aactaaagct                                                   20


<210> 22888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22888
aattatattt gagaaaacta                                                   20


<210> 22889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22889
attataacta aattatattt                                                   20


<210> 22890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22890
aaataacatt gcaaagtaag                                                   20


<210> 22891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22891
ttaaaataac attgcaaagt                                                   20


<210> 22892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22892
acctttaaaa taacattgca                                                   20


<210> 22893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22893
ataggtaagt gagacagcat                                                   20


<210> 22894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22894
gaaaagatag gtaagtgaga                                                   20


<210> 22895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22895
attagaaaag ataggtaagt                                                   20


<210> 22896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22896
gagcattaga aaagataggt                                                   20


<210> 22897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22897
taaggagcat tagaaaagat                                                   20


<210> 22898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22898
gtaaggagca ttagaaaaga                                                   20


<210> 22899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22899
ctgggtaagg agcattagaa                                                   20


<210> 22900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22900
actacctggg taaggagcat                                                   20


<210> 22901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22901
taagaaacta cctgggtaag                                                   20


<210> 22902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22902
tttaagaaac tacctgggta                                                   20


<210> 22903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22903
gtttaagaaa ctacctgggt                                                   20


<210> 22904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22904
atttgtttaa gaaactacct                                                   20


<210> 22905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22905
tatttgttta agaaactacc                                                   20


<210> 22906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22906
tgttcaaata atatttgttt                                                   20


<210> 22907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22907
atcaaggacc tacttatatc                                                   20


<210> 22908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22908
aatcaaggac ctacttatat                                                   20


<210> 22909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22909
ctctcataca taagtaatca                                                   20


<210> 22910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22910
tctctcatac ataagtaatc                                                   20


<210> 22911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22911
taacatcatc tctcatacat                                                   20


<210> 22912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22912
ctaggaagtc caagtgaaag                                                   20


<210> 22913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22913
gctaggaagt ccaagtgaaa                                                   20


<210> 22914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22914
tgctaggaag tccaagtgaa                                                   20


<210> 22915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22915
gtgctaggaa gtccaagtga                                                   20


<210> 22916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22916
ttccctgtgc taggaagtcc                                                   20


<210> 22917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22917
gaaatcttcc ctgtgctagg                                                   20


<210> 22918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22918
atggaaatct tccctgtgct                                                   20


<210> 22919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22919
aatggaaatc ttccctgtgc                                                   20


<210> 22920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22920
gtgacttttt tcatattaaa                                                   20


<210> 22921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22921
aacaatagaa tgatccaaat                                                   20


<210> 22922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22922
tatctaatat tgtcaaacaa                                                   20


<210> 22923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22923
acaagggaat aagttaatca                                                   20


<210> 22924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22924
atattgttta acaagggaat                                                   20


<210> 22925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22925
cagtgcatat tgtttaacaa                                                   20


<210> 22926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22926
tcagtgcata ttgtttaaca                                                   20


<210> 22927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22927
ttcagtgcat attgtttaac                                                   20


<210> 22928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22928
tatatacaca cacagtattt                                                   20


<210> 22929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22929
tatatatata tatacacaca                                                   20


<210> 22930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22930
atttcattta ctgtacatat                                                   20


<210> 22931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22931
taaaatatgc atatatagta                                                   20


<210> 22932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22932
atatataaaa tatgcatata                                                   20


<210> 22933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22933
ttaatatata cagaatatga                                                   20


<210> 22934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22934
ctattatata ttaatatata                                                   20


<210> 22935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22935
taaaaaagta taatactaat                                                   20


<210> 22936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22936
atactagtat attactaaaa                                                   20


<210> 22937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22937
taatactcat tagtatatac                                                   20


<210> 22938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22938
aaaaatagta taatactcat                                                   20


<210> 22939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22939
aaatagtata ttactaaaaa                                                   20


<210> 22940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22940
taattatagc attaattaaa                                                   20


<210> 22941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22941
taatatataa atactaatta                                                   20


<210> 22942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22942
atgcatatta tatatactaa                                                   20


<210> 22943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22943
atgcatatta catatactaa                                                   20


<210> 22944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22944
atgcatatta tatacactaa                                                   20


<210> 22945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22945
ctatatatag tatgcatata                                                   20


<210> 22946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22946
gtatgcatat atactatata                                                   20


<210> 22947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22947
atgcatttac atactatata                                                   20


<210> 22948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22948
atatgcatat gtatactata                                                   20


<210> 22949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22949
ttctgtttac ataaatacat                                                   20


<210> 22950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22950
tttctgttta cataaataca                                                   20


<210> 22951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22951
aatgggtatg tagaaattat                                                   20


<210> 22952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22952
atataaaaac aatgggtatg                                                   20


<210> 22953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22953
gtttaaaata taaaaacaat                                                   20


<210> 22954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22954
ggtttaaaat ataaaaacaa                                                   20


<210> 22955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22955
aatgttctta ttttttaatg                                                   20


<210> 22956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22956
taatgttctt attttttaat                                                   20


<210> 22957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22957
ataatgttct tattttttaa                                                   20


<210> 22958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22958
agatttgaag gaatgagggt                                                   20


<210> 22959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22959
atctagattt gaaggaatga                                                   20


<210> 22960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22960
tatctagatt tgaaggaatg                                                   20


<210> 22961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22961
ttatctagat ttgaaggaat                                                   20


<210> 22962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22962
agagccttat ctagatttga                                                   20


<210> 22963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22963
aagagcctta tctagatttg                                                   20


<210> 22964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22964
agacctctaa gagccttatc                                                   20


<210> 22965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22965
gagagcttta agacctctaa                                                   20


<210> 22966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22966
ctgagagctt taagacctct                                                   20


<210> 22967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22967
cttcggacac tgagagcttt                                                   20


<210> 22968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22968
taaatccctt cggacactga                                                   20


<210> 22969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22969
attaaatccc ttcggacact                                                   20


<210> 22970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 22970
ttggccccat taaatccctt                                                   20


<210> 22971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22971
actcttggct actcagatct                                                   20


<210> 22972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22972
ggcaaacact cttggctact                                                   20


<210> 22973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22973
actttagtgg caaacactct                                                   20


<210> 22974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22974
ggtttctttg gttactttag                                                   20


<210> 22975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22975
ataggtttct ttggttactt                                                   20


<210> 22976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22976
gttattttta taggtttctt                                                   20


<210> 22977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22977
aatgaaaatg ttatttttat                                                   20


<210> 22978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22978
taatgaaaat gttattttta                                                   20


<210> 22979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22979
gagttgcttt tagtgagttt                                                   20


<210> 22980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22980
cctgttgagt tgcttttagt                                                   20


<210> 22981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22981
tgttcctgtt gagttgcttt                                                   20


<210> 22982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22982
accatcttat tgttcctgtt                                                   20


<210> 22983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22983
atccatctta ccctattttt                                                   20


<210> 22984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22984
catccatctt accctatttt                                                   20


<210> 22985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22985
cttttaaatc tatttcctta                                                   20


<210> 22986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 22986
tacattattt cttcttattt                                                   20


<210> 22987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22987
atgcatgatt tctattcaaa                                                   20


<210> 22988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22988
attgattaca aaagtgtgaa                                                   20


<210> 22989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22989
tacaaagcaa ttgattacaa                                                   20


<210> 22990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22990
agatttaata aggaattaca                                                   20


<210> 22991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22991
ttaaattttt agatttaata                                                   20


<210> 22992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 22992
attaaatttt tagatttaat                                                   20


<210> 22993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22993
cattgttcta attaaatttt                                                   20


<210> 22994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 22994
cacacacttc attttgacct                                                   20


<210> 22995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 22995
acacttttag ggcttagctt                                                   20


<210> 22996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22996
aataccacac ttttagggct                                                   20


<210> 22997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 22997
gagtgaatac cacactttta                                                   20


<210> 22998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 22998
tgagtgaata ccacactttt                                                   20


<210> 22999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 22999
ttgagtgaat accacacttt                                                   20


<210> 23000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23000
actaagacat agatttagtt                                                   20


<210> 23001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23001
tttatactaa gacatagatt                                                   20


<210> 23002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23002
ataagattta tactaagaca                                                   20


<210> 23003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23003
tttttaataa gatttatact                                                   20


<210> 23004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23004
tcttcaaaat gttttttaat                                                   20


<210> 23005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23005
ttgccccaac tcaaaatcat                                                   20


<210> 23006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23006
agggcagaag caatcttgtt                                                   20


<210> 23007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23007
ctttagaaat tgtagggcag                                                   20


<210> 23008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23008
aatctttaga aattgtaggg                                                   20


<210> 23009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23009
gctaatcttt agaaattgta                                                   20


<210> 23010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23010
tgctaatctt tagaaattgt                                                   20


<210> 23011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23011
gtgctaatct ttagaaattg                                                   20


<210> 23012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23012
agatctttgg tgctaatctt                                                   20


<210> 23013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23013
aaaactattt ggtagatctt                                                   20


<210> 23014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23014
tcccatgaaa aactatttgg                                                   20


<210> 23015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23015
ttctcccatg aaaaactatt                                                   20


<210> 23016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23016
agctactctc attctctctt                                                   20


<210> 23017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23017
gattgtgaag ccaatgagat                                                   20


<210> 23018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23018
atattgattg tgaagccaat                                                   20


<210> 23019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23019
ttatatctat attgattgtg                                                   20


<210> 23020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23020
ctgatctatc taacatgatg                                                   20


<210> 23021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23021
gatactggtt atggtaattg                                                   20


<210> 23022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23022
tttcttttgg atactggtta                                                   20


<210> 23023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23023
ctcaaatttc ttttggatac                                                   20


<210> 23024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23024
ataagaactc aaatttcttt                                                   20


<210> 23025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23025
ttcttaagat aatttacgat                                                   20


<210> 23026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23026
tgctgttcat gttctttctt                                                   20


<210> 23027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23027
ccagatctaa ggtcatggag                                                   20


<210> 23028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23028
atccagatct aaggtcatgg                                                   20


<210> 23029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23029
gatccagatc taaggtcatg                                                   20


<210> 23030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23030
tagatccaga tctaaggtca                                                   20


<210> 23031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23031
tatttataga tccagatcta                                                   20


<210> 23032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23032
atatttatag atccagatct                                                   20


<210> 23033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23033
agtaaacata tttatagatc                                                   20


<210> 23034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23034
tcagagagta aacatattta                                                   20


<210> 23035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23035
ttccatggaa ctaattcaga                                                   20


<210> 23036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23036
ttttccatgg aactaattca                                                   20


<210> 23037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23037
tattttccat ggaactaatt                                                   20


<210> 23038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23038
aggcaaatga atattttcca                                                   20


<210> 23039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23039
ctcctgctac acaggatgtg                                                   20


<210> 23040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23040
tctcctgcta cacaggatgt                                                   20


<210> 23041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23041
gacatcgtct cctgctacac                                                   20


<210> 23042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23042
agacatcgtc tcctgctaca                                                   20


<210> 23043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23043
tgcattccag acatttttct                                                   20


<210> 23044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23044
cgtaatgaag aactgcattc                                                   20


<210> 23045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23045
tcactaactt attcgtaatg                                                   20


<210> 23046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23046
cctcgaaaaa ttgaatctct                                                   20


<210> 23047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23047
aatagataaa tatataaagt                                                   20


<210> 23048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23048
ctgaaataga taaatatata                                                   20


<210> 23049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23049
gactttttct acgcctgaaa                                                   20


<210> 23050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23050
ttacctgtct ctgatggtaa                                                   20


<210> 23051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23051
gtcagtttac ctgtctctga                                                   20


<210> 23052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23052
acacttcccg cttcatcagt                                                   20


<210> 23053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23053
taaaacactt cccgcttcat                                                   20


<210> 23054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23054
tggaaatact acatgaggat                                                   20


<210> 23055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23055
acatctggaa atactacatg                                                   20


<210> 23056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23056
gacatctgga aatactacat                                                   20


<210> 23057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23057
gttacattta gtgagacatc                                                   20


<210> 23058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23058
aaagccatgt tacatttagt                                                   20


<210> 23059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23059
aaaaaaagcc atgttacatt                                                   20


<210> 23060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23060
ctttaggaat ttaaaaaaaa                                                   20


<210> 23061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23061
tctgctaaat acgtagcttt                                                   20


<210> 23062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23062
ttctgctaaa tacgtagctt                                                   20


<210> 23063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23063
aatttattct gctaaatacg                                                   20


<210> 23064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23064
aaatttaaga gtggcatgag                                                   20


<210> 23065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23065
gcaaatttaa gagtggcatg                                                   20


<210> 23066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23066
ggcaaattta agagtggcat                                                   20


<210> 23067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23067
tgactgggca aatttaagag                                                   20


<210> 23068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23068
gaatgactgg gcaaatttaa                                                   20


<210> 23069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23069
gtgaatgact gggcaaattt                                                   20


<210> 23070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23070
aataatggat gtgaatgact                                                   20


<210> 23071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23071
aaataatgga tgtgaatgac                                                   20


<210> 23072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23072
tgttcttaag tggaaaataa                                                   20


<210> 23073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23073
tattttcaag tgttcttaag                                                   20


<210> 23074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23074
acatattttc aagtgttctt                                                   20


<210> 23075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23075
gagggagcat acatattttc                                                   20


<210> 23076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23076
aaattttctg attaaagagg                                                   20


<210> 23077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23077
aaaaattttc tgattaaaga                                                   20


<210> 23078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23078
aaaaaatttt ctgattaaag                                                   20


<210> 23079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23079
aaaaaaattt tctgattaaa                                                   20


<210> 23080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23080
aaaaaaaaat tttctgatta                                                   20


<210> 23081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23081
agggacaaac attcaaacca                                                   20


<210> 23082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23082
ttccaacatg agtttcaaaa                                                   20


<210> 23083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23083
gttccaacat gagtttcaaa                                                   20


<210> 23084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23084
agttccaaca tgagtttcaa                                                   20


<210> 23085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23085
tgggaattaa gttccaacat                                                   20


<210> 23086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23086
atactgttac attgggaatt                                                   20


<210> 23087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23087
cctcttaata ctgttacatt                                                   20


<210> 23088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23088
gcctcttaat actgttacat                                                   20


<210> 23089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23089
atgacctcat caccttttaa                                                   20


<210> 23090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23090
catgacctca tcacctttta                                                   20


<210> 23091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23091
ctatattcca ttcatgaagg                                                   20


<210> 23092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23092
actctatatt ccattcatga                                                   20


<210> 23093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23093
tactctatat tccattcatg                                                   20


<210> 23094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23094
cactcccatg ataacccatt                                                   20


<210> 23095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23095
tgttcactga gagccaaact                                                   20


<210> 23096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23096
gtgttcactg agagccaaac                                                   20


<210> 23097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23097
tggcgagggg tgttcactga                                                   20


<210> 23098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23098
catggcgagg ggtgttcact                                                   20


<210> 23099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23099
tcatggcatc acatggcgag                                                   20


<210> 23100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23100
ctcatggcat cacatggcga                                                   20


<210> 23101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23101
gctcatggca tcacatggcg                                                   20


<210> 23102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23102
agctcatggc atcacatggc                                                   20


<210> 23103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23103
aggcagctca tggcatcaca                                                   20


<210> 23104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23104
gagagtccca aggcagctca                                                   20


<210> 23105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23105
cacaccagag agtcccaagg                                                   20


<210> 23106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23106
gggcacacca gagagtccca                                                   20


<210> 23107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23107
tgggcacacc agagagtccc                                                   20


<210> 23108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23108
ttgctggtgg gcacaccaga                                                   20


<210> 23109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23109
tcttgctggt gggcacacca                                                   20


<210> 23110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23110
tttcttgctg gtgggcacac                                                   20


<210> 23111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23111
gtgggaactt tcttgctggt                                                   20


<210> 23112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23112
ggtgggaact ttcttgctgg                                                   20


<210> 23113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23113
tctggtggga actttcttgc                                                   20


<210> 23114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23114
gtgaagggtc cacatctggt                                                   20


<210> 23115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23115
ggtgaagggt ccacatctgg                                                   20


<210> 23116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23116
taaggtgaag ggtccacatc                                                   20


<210> 23117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23117
gctgggaagt ctaaggtgaa                                                   20


<210> 23118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23118
agctgggaag tctaaggtga                                                   20


<210> 23119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23119
aagctgggaa gtctaaggtg                                                   20


<210> 23120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23120
tctggaagct gggaagtcta                                                   20


<210> 23121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23121
ttctggaagc tgggaagtct                                                   20


<210> 23122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23122
ttaaagttct ggaagctggg                                                   20


<210> 23123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23123
ttcttaaagt tctggaagct                                                   20


<210> 23124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23124
tttcttaaag ttctggaagc                                                   20


<210> 23125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23125
tttatttctt aaagttctgg                                                   20


<210> 23126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23126
aaatttattt cttaaagttc                                                   20


<210> 23127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23127
ataaagaaat ttatttctta                                                   20


<210> 23128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23128
actggttaaa gtattcaata                                                   20


<210> 23129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23129
tgaatacctg agactggtta                                                   20


<210> 23130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23130
tgtaactgaa tacctgagac                                                   20


<210> 23131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23131
attgctgtaa ctgaatacct                                                   20


<210> 23132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23132
caattataac agacatgtct                                                   20


<210> 23133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23133
aggggctgta tcaattataa                                                   20


<210> 23134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23134
cagacctatt agtattttag                                                   20


<210> 23135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23135
acagacctat tagtatttta                                                   20


<210> 23136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23136
aacagaccta ttagtatttt                                                   20


<210> 23137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23137
gaacagacct attagtattt                                                   20


<210> 23138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23138
ggcttggaga acagacctat                                                   20


<210> 23139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23139
cttaacagtg gcttggagaa                                                   20


<210> 23140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23140
actcacttaa cagtggcttg                                                   20


<210> 23141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23141
aaactcactt aacagtggct                                                   20


<210> 23142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23142
tcataaaact cacttaacag                                                   20


<210> 23143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23143
gtgtcataaa actcacttaa                                                   20


<210> 23144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23144
ctcagttaca aactatacca                                                   20


<210> 23145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23145
tatatatgca tatatattct                                                   20


<210> 23146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23146
tatacgtgtg tgtttataga                                                   20


<210> 23147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23147
tatatatacg tgtgtgttta                                                   20


<210> 23148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23148
taaacagtgt tcttcagtac                                                   20


<210> 23149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23149
ttaaacagtg ttcttcagta                                                   20


<210> 23150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23150
cttgattaaa cagtgttctt                                                   20


<210> 23151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23151
ttgaaactta cttgattaaa                                                   20


<210> 23152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23152
tctgatttct gcaggcttct                                                   20


<210> 23153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23153
gtctgatttc tgcaggcttc                                                   20


<210> 23154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23154
tggacttgtc tgatttctgc                                                   20


<210> 23155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23155
atggacttgt ctgatttctg                                                   20


<210> 23156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23156
attatttgct actcagagaa                                                   20


<210> 23157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23157
cttatattat ttgctactca                                                   20


<210> 23158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23158
tacttatatt atttgctact                                                   20


<210> 23159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23159
tctgttgtat attcagattt                                                   20


<210> 23160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23160
agatgattct gttgtatatt                                                   20


<210> 23161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23161
aatcattgta acaagcccta                                                   20


<210> 23162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23162
atgtggcaaa tcattgtaac                                                   20


<210> 23163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23163
agaaactctg gggttggatg                                                   20


<210> 23164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23164
tgaatcagaa actctggggt                                                   20


<210> 23165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23165
atactgaatc agaaactctg                                                   20


<210> 23166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23166
catactgaat cagaaactct                                                   20


<210> 23167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23167
acatactgaa tcagaaactc                                                   20


<210> 23168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23168
aaccccaaga catactgaat                                                   20


<210> 23169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23169
caaattctgc ccccaacccc                                                   20


<210> 23170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23170
atgtaggtga gaactcataa                                                   20


<210> 23171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23171
acatgtaggt gagaactcat                                                   20


<210> 23172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23172
aaacgttggc acatgtaggt                                                   20


<210> 23173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23173
ctgaaaacgt tggcacatgt                                                   20


<210> 23174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23174
actgaaaacg ttggcacatg                                                   20


<210> 23175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23175
ggtctcaaaa ctgaaaacgt                                                   20


<210> 23176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23176
cagcagttgt tcttgaagga                                                   20


<210> 23177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23177
tctacagcag ttgttcttga                                                   20


<210> 23178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23178
atctacagca gttgttcttg                                                   20


<210> 23179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23179
gtatagaaac ttatctacag                                                   20


<210> 23180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23180
aaagtataga aacttatcta                                                   20


<210> 23181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23181
tttttttttt ctgaaaagta                                                   20


<210> 23182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23182
tgattttttt tttttctgaa                                                   20


<210> 23183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23183
gggacacaga tttgggggag                                                   20


<210> 23184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23184
tttgggacac agatttgggg                                                   20


<210> 23185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23185
attttgggac acagatttgg                                                   20


<210> 23186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23186
aattttggga cacagatttg                                                   20


<210> 23187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23187
aaattttggg acacagattt                                                   20


<210> 23188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23188
caaattttgg gacacagatt                                                   20


<210> 23189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23189
gagatgcaaa ttttgggaca                                                   20


<210> 23190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23190
ctgacagaga tgcaaatttt                                                   20


<210> 23191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23191
gctgacagag atgcaaattt                                                   20


<210> 23192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23192
acacaatatt cttgctgaca                                                   20


<210> 23193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23193
ccacacaata ttcttgctga                                                   20


<210> 23194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23194
aatgcaaagc acagagagta                                                   20


<210> 23195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23195
aatataatgc aaagcacaga                                                   20


<210> 23196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23196
caaatataat gcaaagcaca                                                   20


<210> 23197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23197
aacaaatata atgcaaagca                                                   20


<210> 23198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23198
aaacgaacaa atataatgca                                                   20


<210> 23199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23199
tgaaatatta tttaatattt                                                   20


<210> 23200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23200
tgtaatgtgc agaaatcagg                                                   20


<210> 23201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23201
tatgtaatgt gcagaaatca                                                   20


<210> 23202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23202
gtatgtaatg tgcagaaatc                                                   20


<210> 23203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23203
ggtatgtaat gtgcagaaat                                                   20


<210> 23204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23204
gttcaggggt atgtaatgtg                                                   20


<210> 23205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23205
gagtataacc tcctgttcag                                                   20


<210> 23206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23206
tgagtataac ctcctgttca                                                   20


<210> 23207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23207
gtgagtataa cctcctgttc                                                   20


<210> 23208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23208
agtgagtata acctcctgtt                                                   20


<210> 23209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23209
ttaaagtgat gattctcagt                                                   20


<210> 23210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23210
aaatttaaag tgatgattct                                                   20


<210> 23211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23211
ttgttttatt tgaaaattta                                                   20


<210> 23212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23212
gagatatggc tgtttaataa                                                   20


<210> 23213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23213
ttattttaaa ttaagagata                                                   20


<210> 23214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23214
ttgaacttat tttaaattaa                                                   20


<210> 23215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23215
aattgaactt attttaaatt                                                   20


<210> 23216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23216
tgtaagaaat gaaggtttac                                                   20


<210> 23217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23217
tcattcagtg taagaaatga                                                   20


<210> 23218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23218
atcattcagt gtaagaaatg                                                   20


<210> 23219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23219
tcattttcat cattcagtgt                                                   20


<210> 23220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23220
atacactcat tttcatcatt                                                   20


<210> 23221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23221
taaaaaatta tacaatattt                                                   20


<210> 23222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23222
cttaaactgt aaatatgacg                                                   20


<210> 23223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23223
tcttaaactg taaatatgac                                                   20


<210> 23224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 23224
ctcttaaact gtaaatatga                                                   20


<210> 23225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23225
aagaaattat agaaggaatg                                                   20


<210> 23226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23226
aaataagaag aaattataga                                                   20


<210> 23227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23227
caaataagaa gaaattatag                                                   20


<210> 23228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23228
ccccaaataa gaagaaatta                                                   20


<210> 23229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23229
gaaaggctgc cccaaataag                                                   20


<210> 23230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23230
gaagaaaggc tgccccaaat                                                   20


<210> 23231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23231
aatatagtag ttttgaagaa                                                   20


<210> 23232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23232
taatatagta gttttgaaga                                                   20


<210> 23233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23233
tttgtaatat agtagttttg                                                   20


<210> 23234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23234
tgggtatttt tgtaatatag                                                   20


<210> 23235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23235
aaatgggtat ttttgtaata                                                   20


<210> 23236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23236
aaaatgaaaa atgataaaat                                                   20


<210> 23237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23237
aaaaatgaaa aatgataaaa                                                   20


<210> 23238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23238
cattcatata tcaagttatc                                                   20


<210> 23239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23239
caattaatca ttcatatatc                                                   20


<210> 23240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23240
gagaattcta acttcggata                                                   20


<210> 23241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 23241
ctctatgaga attctaactt                                                   20


<210> 23242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23242
ttatcttagg tttcctctat                                                   20


<210> 23243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23243
caccttatat gtgttatctt                                                   20


<210> 23244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23244
acaccttata tgtgttatct                                                   20


<210> 23245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23245
atgtgaaaaa atttttaaca                                                   20


<210> 23246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23246
tccagcttgg gcgacagggt                                                   20


<210> 23247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23247
gcactccagc ttgggcgaca                                                   20


<210> 23248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23248
tgcactccag cttgggcgac                                                   20


<210> 23249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23249
ctgcactcca gcttgggcga                                                   20


<210> 23250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23250
gtgccactgc actccagctt                                                   20


<210> 23251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23251
cgtgccactg cactccagct                                                   20


<210> 23252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23252
gagatcgtgc cactgcactc                                                   20


<210> 23253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23253
ggcagaggtt tcagtgagtc                                                   20


<210> 23254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23254
cggtaggcag aggtttcagt                                                   20


<210> 23255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23255
aacccggtag gcagaggttt                                                   20


<210> 23256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23256
cgcttgaacc cggtaggcag                                                   20


<210> 23257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23257
tcgcttgaac ccggtaggca                                                   20


<210> 23258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23258
aatcgcttga acccggtagg                                                   20


<210> 23259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23259
aagaatcgct tgaacccggt                                                   20


<210> 23260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23260
gaagaatcgc ttgaacccgg                                                   20


<210> 23261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 23261
gcagaagaat cgcttgaacc                                                   20


<210> 23262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23262
tactcaggag gctgaggcag                                                   20


<210> 23263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23263
agctactcag gaggctgagg                                                   20


<210> 23264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23264
cccagctact caggaggctg                                                   20


<210> 23265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23265
tcccagctac tcaggaggct                                                   20


<210> 23266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23266
tgtaatccca gctactcagg                                                   20


<210> 23267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23267
ctgtaatccc agctactcag                                                   20


<210> 23268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23268
gcctgtaatc ccagctactc                                                   20


<210> 23269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23269
tgcctgtaat cccagctact                                                   20


<210> 23270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23270
gtggcaggtg cctgtaatcc                                                   20


<210> 23271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23271
aattagccag acatggtggc                                                   20


<210> 23272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23272
aaattagcca gacatggtgg                                                   20


<210> 23273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23273
aaaaaattag ccagacatgg                                                   20


<210> 23274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23274
tacaaaaaat tagccagaca                                                   20


<210> 23275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23275
aaaaaataca aaaaattagc                                                   20


<210> 23276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23276
tactaaaaaa tacaaaaaat                                                   20


<210> 23277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23277
tgagaccagc ctggccaaca                                                   20


<210> 23278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23278
tcaggagttt gagaccagcc                                                   20


<210> 23279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23279
tgaggtcagg agtttgagac                                                   20


<210> 23280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23280
tcacctgagg tcaggagttt                                                   20


<210> 23281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23281
ggtggatcac ctgaggtcag                                                   20


<210> 23282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23282
caggtggatc acctgaggtc                                                   20


<210> 23283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23283
gcaggtggat cacctgaggt                                                   20


<210> 23284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23284
cgaggcaggt ggatcacctg                                                   20


<210> 23285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23285
ccgaggcagg tggatcacct                                                   20


<210> 23286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23286
ctttgagagt ccgaggcagg                                                   20


<210> 23287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23287
gcactttgag agtccgaggc                                                   20


<210> 23288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23288
agcactttga gagtccgagg                                                   20


<210> 23289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23289
cccagcactt tgagagtccg                                                   20


<210> 23290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23290
tcccagcact ttgagagtcc                                                   20


<210> 23291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23291
ctgtaatccc agcactttga                                                   20


<210> 23292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23292
gcctgtaatc ccagcacttt                                                   20


<210> 23293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23293
gtagctcacg cctgtaatcc                                                   20


<210> 23294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23294
tggcttctgg ccaggcgcgg                                                   20


<210> 23295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 23295
ttttggcttc tggccaggcg                                                   20


<210> 23296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23296
taaacttttg gcttctggcc                                                   20


<210> 23297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23297
ataaactttt ggcttctggc                                                   20


<210> 23298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23298
cttcataaac ttttggcttc                                                   20


<210> 23299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23299
ttcaaagctt cataaacttt                                                   20


<210> 23300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23300
aatttctcaa ctgttattca                                                   20


<210> 23301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23301
aattagtcat atttactcaa                                                   20


<210> 23302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23302
actgcaaaat gttaccaaat                                                   20


<210> 23303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23303
caagtaagca tgatcataca                                                   20


<210> 23304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23304
tggattagaa aatcacaagt                                                   20


<210> 23305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23305
tatgtggatt agaaaatcac                                                   20


<210> 23306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23306
atacagcatc atatgtggat                                                   20


<210> 23307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23307
aattcataca gcatcatatg                                                   20


<210> 23308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23308
taagaaaagt tgaattcata                                                   20


<210> 23309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23309
cattatcgag cttttaagaa                                                   20


<210> 23310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23310
gtttgcatta tcgagctttt                                                   20


<210> 23311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23311
aaccaagggt ttgcattatc                                                   20


<210> 23312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23312
gtgctttaaa atttaaccaa                                                   20


<210> 23313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23313
agtgctttaa aatttaacca                                                   20


<210> 23314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23314
aagtgcttta aaatttaacc                                                   20


<210> 23315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23315
gcaaatttgt atatgccaat                                                   20


<210> 23316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23316
atgatgcctg acataattag                                                   20


<210> 23317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23317
tatgatgcct gacataatta                                                   20


<210> 23318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23318
catatgatgc ctgacataat                                                   20


<210> 23319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23319
ataatcagtc atagttttta                                                   20


<210> 23320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23320
ctataatcag tcatagtttt                                                   20


<210> 23321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23321
aaacatccta taatcagtca                                                   20


<210> 23322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23322
gggaagaaac atcctataat                                                   20


<210> 23323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23323
cctaaccttt gtgtttaggg                                                   20


<210> 23324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23324
aaacctaacc tttgtgttta                                                   20


<210> 23325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23325
gaaacctaac ctttgtgttt                                                   20


<210> 23326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23326
agaaacctaa cctttgtgtt                                                   20


<210> 23327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23327
tactaattct tctagatttt                                                   20


<210> 23328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23328
ttatctttta ctaattcttc                                                   20


<210> 23329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23329
tctcccagtc ttatttttct                                                   20


<210> 23330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23330
attttataac ctcaatctcc                                                   20


<210> 23331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23331
atattttgta ttaattaaaa                                                   20


<210> 23332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 23332
gactctcaaa tagaaactaa                                                   20


<210> 23333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23333
tgagatcaag gactctcaaa                                                   20


<210> 23334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23334
taaaatagtc ggtgagatca                                                   20


<210> 23335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23335
ttaaaatagt cggtgagatc                                                   20


<210> 23336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23336
gaaatcttaa aatagtcggt                                                   20


<210> 23337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 23337
agaagaaatc ttaaaatagt                                                   20


<210> 23338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23338
atagagaaga aatcttaaaa                                                   20


<210> 23339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23339
ggcttctgat tgagatagag                                                   20


<210> 23340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23340
acaggcttct gattgagata                                                   20


<210> 23341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23341
ttacaggctt ctgattgaga                                                   20


<210> 23342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23342
atttttacag gcttctgatt                                                   20


<210> 23343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23343
cgaagtagaa atatttttac                                                   20


<210> 23344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23344
acgaagtaga aatattttta                                                   20


<210> 23345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23345
tacatattat tttaacgaag                                                   20


<210> 23346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23346
gtttacatat tattttaacg                                                   20


<210> 23347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23347
gaaaatacat aataattctt                                                   20


<210> 23348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23348
actgttgaat acttggatga                                                   20


<210> 23349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23349
tcaaagaact gttgaatact                                                   20


<210> 23350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23350
aattttagat aataaattca                                                   20


<210> 23351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23351
tattattaat gtaataattt                                                   20


<210> 23352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23352
tggcagtggg gcagaggagt                                                   20


<210> 23353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23353
atggcagtgg ggcagaggag                                                   20


<210> 23354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23354
agaatggcag tggggcagag                                                   20


<210> 23355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23355
ccagaatggc agtggggcag                                                   20


<210> 23356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23356
tccagaatgg cagtggggca                                                   20


<210> 23357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23357
tctccagaat ggcagtgggg                                                   20


<210> 23358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23358
tcatctccag aatggcagtg                                                   20


<210> 23359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23359
ttcatctcca gaatggcagt                                                   20


<210> 23360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23360
cttcatctcc agaatggcag                                                   20


<210> 23361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23361
gcccttcatc tccagaatgg                                                   20


<210> 23362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23362
cttgcccttc atctccagaa                                                   20


<210> 23363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23363
tgcgacttgc ccttcatctc                                                   20


<210> 23364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23364
attataggaa aaaccaaaat                                                   20


<210> 23365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23365
tctatctcag acccaattat                                                   20


<210> 23366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23366
atctatctca gacccaatta                                                   20


<210> 23367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23367
aaattttaaa atatctatct                                                   20


<210> 23368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23368
ctttgtattt ggggagagag                                                   20


<210> 23369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23369
taactttgta tttggggaga                                                   20


<210> 23370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23370
gttaactttg tatttgggga                                                   20


<210> 23371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23371
aagttaactt tgtatttggg                                                   20


<210> 23372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23372
caaagttaac tttgtatttg                                                   20


<210> 23373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23373
acaaagttaa ctttgtattt                                                   20


<210> 23374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23374
tacaaagtta actttgtatt                                                   20


<210> 23375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23375
aaaatcatta tacaaataca                                                   20


<210> 23376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23376
catcaagttg gctgatatgt                                                   20


<210> 23377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23377
ggatgagggg cacatcaagt                                                   20


<210> 23378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23378
gagaggatga ggggcacatc                                                   20


<210> 23379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23379
ggaagataag agaggatgag                                                   20


<210> 23380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23380
tggaagataa gagaggatga                                                   20


<210> 23381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23381
ttggaagata agagaggatg                                                   20


<210> 23382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23382
attggaagat aagagaggat                                                   20


<210> 23383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23383
gtaaaattgg aagataagag                                                   20


<210> 23384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23384
tgtaaaattg gaagataaga                                                   20


<210> 23385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23385
aatgtaaaat tggaagataa                                                   20


<210> 23386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23386
ataatgtaaa attggaagat                                                   20


<210> 23387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23387
tattcataat gtaaaattgg                                                   20


<210> 23388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23388
gattattcat aatgtaaaat                                                   20


<210> 23389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23389
cagagacaca gattaaagag                                                   20


<210> 23390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23390
gcagagacac agattaaaga                                                   20


<210> 23391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23391
gggcagagac acagattaaa                                                   20


<210> 23392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23392
aagggcagag acacagatta                                                   20


<210> 23393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23393
atgataaaag ggcagagaca                                                   20


<210> 23394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23394
taggagatga taaaagggca                                                   20


<210> 23395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23395
agtaggagat gataaaaggg                                                   20


<210> 23396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23396
agaagtagga gatgataaaa                                                   20


<210> 23397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23397
tagaagtagg agatgataaa                                                   20


<210> 23398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23398
ttagaagtag gagatgataa                                                   20


<210> 23399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23399
aaaacaaaat ttagaagtag                                                   20


<210> 23400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23400
ataaaacaaa atttagaagt                                                   20


<210> 23401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23401
aataaaacaa aatttagaag                                                   20


<210> 23402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23402
aagaataaaa caaaatttag                                                   20


<210> 23403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23403
gttaagaata aaacaaaatt                                                   20


<210> 23404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23404
atttgaatgt cattcttgtt                                                   20


<210> 23405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23405
tttttatgtt ttctgcaaag                                                   20


<210> 23406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23406
gttttttatg ttttctgcaa                                                   20


<210> 23407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23407
agttttttat gttttctgca                                                   20


<210> 23408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23408
acattgtaac atttataatt                                                   20


<210> 23409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23409
atctgtgagg aatattagaa                                                   20


<210> 23410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23410
aatatatctg tgaggaatat                                                   20


<210> 23411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23411
ccagtggaaa tatatctgtg                                                   20


<210> 23412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23412
gccagtggaa atatatctgt                                                   20


<210> 23413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23413
agaaatatta acacagccag                                                   20


<210> 23414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23414
tttagaaata ttaacacagc                                                   20


<210> 23415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23415
ttcttttaga aatattaaca                                                   20


<210> 23416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23416
aggctatagg tttattcttt                                                   20


<210> 23417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23417
ttcatatatt ttcaggctat                                                   20


<210> 23418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23418
cttcatatat tttcaggcta                                                   20


<210> 23419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23419
gttaagcttc atatattttc                                                   20


<210> 23420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23420
tgttaagctt catatatttt                                                   20


<210> 23421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23421
tatcatattt taattttgtt                                                   20


<210> 23422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23422
ttttgagtac attttaaaag                                                   20


<210> 23423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23423
cttttgagta cattttaaaa                                                   20


<210> 23424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23424
tacttttgag tacattttaa                                                   20


<210> 23425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23425
ttgttgatgt aggtactttt                                                   20


<210> 23426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23426
gatttcctaa ttgttgatgt                                                   20


<210> 23427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23427
ggatttccta attgttgatg                                                   20


<210> 23428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23428
caccaatgcc tggtgttggc                                                   20


<210> 23429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23429
atttcaccaa tgcctggtgt                                                   20


<210> 23430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23430
aaacatattt caccaatgcc                                                   20


<210> 23431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23431
cttctaaaat ggatagcata                                                   20


<210> 23432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23432
ggaaatgctt ctaaaatgga                                                   20


<210> 23433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23433
ttctggaaat gcttctaaaa                                                   20


<210> 23434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23434
cttcacttac atcttcattc                                                   20


<210> 23435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23435
ttatcctgga gtatgcagac                                                   20


<210> 23436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23436
taagattatc ctggagtatg                                                   20


<210> 23437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23437
agaccattaa gattatcctg                                                   20


<210> 23438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23438
aaagaccatt aagattatcc                                                   20


<210> 23439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23439
ttgaaaggaa aaagaccatt                                                   20


<210> 23440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23440
atatttatat tgaaaggaaa                                                   20


<210> 23441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23441
ttgaagatat ttatattgaa                                                   20


<210> 23442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23442
tttgaagata tttatattga                                                   20


<210> 23443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23443
attatttcca caggcttttg                                                   20


<210> 23444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23444
aacttgaata ttatttccac                                                   20


<210> 23445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23445
aaacttgaat attatttcca                                                   20


<210> 23446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23446
ttaaatgaat catgaagctt                                                   20


<210> 23447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23447
ttttttttaa atgaatcatg                                                   20


<210> 23448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23448
tgtttcagca gtcttagcat                                                   20


<210> 23449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23449
atattatgtt tcagcagtct                                                   20


<210> 23450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23450
atgtcaatat tatgtttcag                                                   20


<210> 23451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23451
cccatgtcaa tattatgttt                                                   20


<210> 23452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23452
aaaccagaaa aaatgtcagc                                                   20


<210> 23453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23453
ctgtaaacca gaaaaaatgt                                                   20


<210> 23454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23454
gttatatgat aactgtaaac                                                   20


<210> 23455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23455
agcagcactg gtgagaaggc                                                   20


<210> 23456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23456
cagcagcagc actggtgaga                                                   20


<210> 23457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23457
ccagcagcag cactggtgag                                                   20


<210> 23458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23458
agaccagcag cagcactggt                                                   20


<210> 23459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23459
ctgaagacca gcagcagcac                                                   20


<210> 23460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23460
tgacctctga agaccagcag                                                   20


<210> 23461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23461
tcttgacctc tgaagaccag                                                   20


<210> 23462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23462
ttctcttgac ctctgaagac                                                   20


<210> 23463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23463
gcactttctc ttgacctctg                                                   20


<210> 23464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23464
tgagtctttt tgtggattat                                                   20


<210> 23465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23465
agagatcatg agtctttttg                                                   20


<210> 23466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23466
gatcaggtgt cagagatcat                                                   20


<210> 23467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23467
gtggaaatga tcaggtgtca                                                   20


<210> 23468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23468
aggtggaaat gatcaggtgt                                                   20


<210> 23469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23469
agatggaggt ggaaatgatc                                                   20


<210> 23470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23470
cagatggagg tggaaatgat                                                   20


<210> 23471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23471
gaggaggaat cagatggagg                                                   20


<210> 23472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23472
aaagaggagg aatcagatgg                                                   20


<210> 23473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23473
gaaagaggag gaatcagatg                                                   20


<210> 23474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23474
gagaaagagg aggaatcaga                                                   20


<210> 23475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23475
aatggagaaa gaggaggaat                                                   20


<210> 23476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23476
aattttaatg gagaaagagg                                                   20


<210> 23477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23477
caattttaat ggagaaagag                                                   20


<210> 23478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23478
tccaatttta atggagaaag                                                   20


<210> 23479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23479
atccaatttt aatggagaaa                                                   20


<210> 23480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23480
ttatccaatt ttaatggaga                                                   20


<210> 23481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23481
ggacttatcc aattttaatg                                                   20


<210> 23482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23482
taggacttat ccaattttaa                                                   20


<210> 23483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23483
ggatcatgtc ttaaattgct                                                   20


<210> 23484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23484
gggatcatgt cttaaattgc                                                   20


<210> 23485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23485
ttataacagt ggctggccat                                                   20


<210> 23486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23486
tttataacag tggctggcca                                                   20


<210> 23487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23487
gaaaagttta taacagtggc                                                   20


<210> 23488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23488
atgtgaaaag tttataacag                                                   20


<210> 23489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23489
aggatgtgaa aagtttataa                                                   20


<210> 23490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23490
aggggagtgt aggatgtgaa                                                   20


<210> 23491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23491
gtggggaaaa aggggagtgt                                                   20


<210> 23492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23492
ggtggggaaa aaggggagtg                                                   20


<210> 23493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23493
ctactggtgg ggaaaaaggg                                                   20


<210> 23494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23494
tcctactggt ggggaaaaag                                                   20


<210> 23495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23495
atcctactgg tggggaaaaa                                                   20


<210> 23496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23496
catcctactg gtggggaaaa                                                   20


<210> 23497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23497
acatcctact ggtggggaaa                                                   20


<210> 23498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23498
ggctccacat cctactggtg                                                   20


<210> 23499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23499
aggctccaca tcctactggt                                                   20


<210> 23500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23500
caggctccac atcctactgg                                                   20


<210> 23501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23501
agacaggctc cacatcctac                                                   20


<210> 23502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23502
gcatttgaga gctgaaagac                                                   20


<210> 23503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23503
agcatttgag agctgaaaga                                                   20


<210> 23504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23504
cacaagcatt tgagagctga                                                   20


<210> 23505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23505
tgggatgcac aagcatttga                                                   20


<210> 23506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23506
actgggatgc acaagcattt                                                   20


<210> 23507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23507
tactaggcac tgggatgcac                                                   20


<210> 23508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23508
ttaacatggt actaggcact                                                   20


<210> 23509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23509
attaacatgg tactaggcac                                                   20


<210> 23510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23510
gctgttatta acatggtact                                                   20


<210> 23511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23511
tgctgttatt aacatggtac                                                   20


<210> 23512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23512
tcctgctgct gttattaaca                                                   20


<210> 23513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23513
agctactgca gtcattcatt                                                   20


<210> 23514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23514
ataggcctat taagctactg                                                   20


<210> 23515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23515
ctgtgttcta taggcctatt                                                   20


<210> 23516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23516
aagcaccctc tgtgttctat                                                   20


<210> 23517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23517
aaagcaccct ctgtgttcta                                                   20


<210> 23518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23518
ggatgaatag tcaaaggaaa                                                   20


<210> 23519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23519
atatatggat gaatagtcaa                                                   20


<210> 23520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23520
aatatatgga tgaatagtca                                                   20


<210> 23521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23521
aaggataata tatggatgaa                                                   20


<210> 23522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23522
aagctttgaa ggataatata                                                   20


<210> 23523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23523
ttttagagct gaagctttga                                                   20


<210> 23524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23524
tttttagagc tgaagctttg                                                   20


<210> 23525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23525
aacagtgatt tttagagctg                                                   20


<210> 23526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23526
gaatagaaca gtgattttta                                                   20


<210> 23527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23527
gagaatagaa cagtgatttt                                                   20


<210> 23528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23528
cattaatgga gagaatagaa                                                   20


<210> 23529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23529
caccgcatta atggagagaa                                                   20


<210> 23530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23530
ggaagcaccg cattaatgga                                                   20


<210> 23531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23531
taggaagcac cgcattaatg                                                   20


<210> 23532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23532
cataggaagc accgcattaa                                                   20


<210> 23533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23533
aatttcttgg aaagcatagg                                                   20


<210> 23534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23534
taaaatttct tggaaagcat                                                   20


<210> 23535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23535
ctaaaatttc ttggaaagca                                                   20


<210> 23536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23536
acttactaaa atttcttgga                                                   20


<210> 23537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23537
tgtcacttac taaaatttct                                                   20


<210> 23538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23538
cgtaagccct acattagata                                                   20


<210> 23539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23539
agcgtaagcc ctacattaga                                                   20


<210> 23540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23540
gtaaagcgta agccctacat                                                   20


<210> 23541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23541
aattagtaac agtaaagcgt                                                   20


<210> 23542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23542
aaccaaaatt agtaacagta                                                   20


<210> 23543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23543
gtgataacca aaattagtaa                                                   20


<210> 23544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23544
aaatgagtga taaccaaaat                                                   20


<210> 23545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23545
tacacaaaat aggagtaaat                                                   20


<210> 23546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23546
gaagagcata cacaaaatag                                                   20


<210> 23547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23547
cagaagagca tacacaaaat                                                   20


<210> 23548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23548
acagaagagc atacacaaaa                                                   20


<210> 23549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23549
ttgtggctcc tcagacagaa                                                   20


<210> 23550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23550
tgttgtggct cctcagacag                                                   20


<210> 23551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23551
ctgtgttgtg gctcctcaga                                                   20


<210> 23552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23552
ttcactgtgt tgtggctcct                                                   20


<210> 23553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23553
cctgtccttt cactgtgttg                                                   20


<210> 23554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23554
gtggctgaag tctaaagtca                                                   20


<210> 23555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23555
ggacatgtgg ctgaagtcta                                                   20


<210> 23556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23556
tgtcaaggga catgtggctg                                                   20


<210> 23557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23557
attctttgtc aagggacatg                                                   20


<210> 23558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23558
cctttcaaat tctttgtcaa                                                   20


<210> 23559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23559
tcctttcaaa ttctttgtca                                                   20


<210> 23560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23560
gtcctttcaa attctttgtc                                                   20


<210> 23561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23561
caacaatgag cccaattttt                                                   20


<210> 23562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23562
tcttggctca ctgcaacaat                                                   20


<210> 23563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23563
ggagtgcagt ggcgtgatct                                                   20


<210> 23564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23564
ttgcccaggc tggagtgcag                                                   20


<210> 23565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23565
ctgttgccca ggctggagtg                                                   20


<210> 23566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23566
ttgctctgtt gcccaggctg                                                   20


<210> 23567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23567
tcttgctctg ttgcccaggc                                                   20


<210> 23568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23568
agagtcttgc tctgttgccc                                                   20


<210> 23569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23569
cagagtcttg ctctgttgcc                                                   20


<210> 23570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23570
tttttttttt ttttgagaca                                                   20


<210> 23571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23571
tttttttttt ttttttgaga                                                   20


<210> 23572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23572
tttttttttt tttttttttt                                                   20


<210> 23573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23573
atcattttca gtgtctcaat                                                   20


<210> 23574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23574
ttgagatcag caatcatttt                                                   20


<210> 23575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23575
cactttagac ctgttgagat                                                   20


<210> 23576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23576
tctaacactt tagacctgtt                                                   20


<210> 23577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23577
aagagaaagt tctaacactt                                                   20


<210> 23578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23578
gtgtttcgat ctgaaagaga                                                   20


<210> 23579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23579
aatagtgttt cgatctgaaa                                                   20


<210> 23580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23580
ttaatagtgt ttcgatctga                                                   20


<210> 23581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23581
attttatcca acagggttaa                                                   20


<210> 23582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23582
gactttcatt ttatccaaca                                                   20


<210> 23583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23583
tgactttcat tttatccaac                                                   20


<210> 23584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23584
ttgactttca ttttatccaa                                                   20


<210> 23585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23585
atattaacca cgaaggatac                                                   20


<210> 23586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23586
aatattaacc acgaaggata                                                   20


<210> 23587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23587
aaatataata ttaaccacga                                                   20


<210> 23588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23588
taaatataat attaaccacg                                                   20


<210> 23589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23589
acaagttcat gactgtagac                                                   20


<210> 23590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23590
cacaagttca tgactgtaga                                                   20


<210> 23591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23591
atggcacaag ttcatgactg                                                   20


<210> 23592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23592
aagaagaatc tgaatggcac                                                   20


<210> 23593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23593
tagaataaga agaatctgaa                                                   20


<210> 23594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23594
aaagcagaac gtagaataag                                                   20


<210> 23595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23595
ttgaaagcag aacgtagaat                                                   20


<210> 23596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23596
agagtattga aagcagaacg                                                   20


<210> 23597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23597
taattttaga gtattgaaag                                                   20


<210> 23598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23598
ggataatttt agagtattga                                                   20


<210> 23599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23599
aactgctaag gataatttta                                                   20


<210> 23600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23600
aaaactgcta aggataattt                                                   20


<210> 23601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23601
acagtttccc aaaactgcta                                                   20


<210> 23602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23602
aacagtttcc caaaactgct                                                   20


<210> 23603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23603
ttcttcaata ttgataccaa                                                   20


<210> 23604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23604
tgcatcttag taggtccatt                                                   20


<210> 23605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23605
ccttcttttt gcatcttagt                                                   20


<210> 23606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23606
accttctttt tgcatcttag                                                   20


<210> 23607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23607
gggaccttct ttttgcatct                                                   20


<210> 23608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23608
cagaacctct gccaactgct                                                   20


<210> 23609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23609
tcagaacctc tgccaactgc                                                   20


<210> 23610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23610
acttcaattc cattgaattt                                                   20


<210> 23611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23611
aggaaaatcc tgagggctag                                                   20


<210> 23612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23612
gggaggaaaa tcctgagggc                                                   20


<210> 23613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23613
ggaggggagg aaaatcctga                                                   20


<210> 23614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23614
tggaggggag gaaaatcctg                                                   20


<210> 23615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23615
gtggagggga ggaaaatcct                                                   20


<210> 23616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23616
ttgggggtgg agtggagggg                                                   20


<210> 23617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23617
tttgggggtg gagtggaggg                                                   20


<210> 23618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23618
aatttggggg tggagtggag                                                   20


<210> 23619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23619
gaatttgggg gtggagtgga                                                   20


<210> 23620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23620
agaatttggg ggtggagtgg                                                   20


<210> 23621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23621
cagaatttgg gggtggagtg                                                   20


<210> 23622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23622
tccagaattt gggggtggag                                                   20


<210> 23623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23623
tcctccagaa tttgggggtg                                                   20


<210> 23624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23624
attcctccag aatttggggg                                                   20


<210> 23625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23625
ctgattcctc cagaatttgg                                                   20


<210> 23626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23626
cctgattcct ccagaatttg                                                   20


<210> 23627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23627
gcctgattcc tccagaattt                                                   20


<210> 23628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23628
tgcctgattc ctccagaatt                                                   20


<210> 23629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23629
gatggcttgc ctgattcctc                                                   20


<210> 23630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23630
tgccatagtt tcggtttaga                                                   20


<210> 23631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23631
tcattgccat agtttcggtt                                                   20


<210> 23632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 23632
ctgagtcatt gccatagttt                                                   20


<210> 23633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23633
caaggactga gtcattgcca                                                   20


<210> 23634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23634
gtctttgtat ttcaaggact                                                   20


<210> 23635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23635
ttccttgtct ttgtatttca                                                   20


<210> 23636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23636
cttccttgtc tttgtatttc                                                   20


<210> 23637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23637
gcttcgtttt ccttgtgact                                                   20


<210> 23638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23638
tgtacaccag ttctagaaac                                                   20


<210> 23639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23639
ctgtacacca gttctagaaa                                                   20


<210> 23640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23640
ctgaccctgt acaccagttc                                                   20


<210> 23641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23641
tctgctctga ccctgtacac                                                   20


<210> 23642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 23642
ctcatcatca agacttcctg                                                   20


<210> 23643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23643
agagagaggt tctcatcatc                                                   20


<210> 23644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23644
ctctgggacc agtcagagag                                                   20


<210> 23645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23645
gctctgggac cagtcagaga                                                   20


<210> 23646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23646
ctgctctggg accagtcaga                                                   20


<210> 23647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23647
tcctgctctg ggaccagtca                                                   20


<210> 23648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23648
attcctgctc tgggaccagt                                                   20


<210> 23649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23649
tctaattcct gctctgggac                                                   20


<210> 23650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23650
tgaattctaa ttcctgctct                                                   20


<210> 23651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23651
ctgaattcta attcctgctc                                                   20


<210> 23652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23652
ctggaagcta gaacccctgt                                                   20


<210> 23653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23653
tctggaagct agaacccctg                                                   20


<210> 23654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23654
acaaaattgg ttctggaagc                                                   20


<210> 23655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23655
atccacaaaa ttggttctgg                                                   20


<210> 23656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23656
tacatccaca aaattggttc                                                   20


<210> 23657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23657
tgctcctaca tccacaaaat                                                   20


<210> 23658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23658
aatcagatag agctcacata                                                   20


<210> 23659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23659
aaatcagata gagctcacat                                                   20


<210> 23660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23660
gttaagtcct aaatcagata                                                   20


<210> 23661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23661
gcgttaagtc ctaaatcaga                                                   20


<210> 23662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23662
taaagcgtta agtcctaaat                                                   20


<210> 23663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23663
tttagtaaca gtaaagcgtt                                                   20


<210> 23664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23664
aactgaattt agtaacagta                                                   20


<210> 23665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23665
gtggtaactg aatttagtaa                                                   20


<210> 23666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23666
aaatgagtgg taactgaatt                                                   20


<210> 23667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23667
acaaaacaga aataaatgag                                                   20


<210> 23668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23668
tacacaaaac agaaataaat                                                   20


<210> 23669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23669
aaagaagagt atacacaaaa                                                   20


<210> 23670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23670
ttgtggctcc tcagaaagaa                                                   20


<210> 23671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23671
tgttgtggct cctcagaaag                                                   20


<210> 23672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23672
ctgtgttgtg gctcctcaga                                                   20


<210> 23673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23673
ttcactgtgt tgtggctcct                                                   20


<210> 23674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23674
catatctttt cactgtgttg                                                   20


<210> 23675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23675
tgaattgaca tctaaaatca                                                   20


<210> 23676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23676
cccaaagcta gtaaatgaca                                                   20


<210> 23677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23677
gtcccaaagc tagtaaatga                                                   20


<210> 23678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23678
gttgcttaat gtcccaaagc                                                   20


<210> 23679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23679
aaaagttgct taatgtccca                                                   20


<210> 23680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23680
gaagctgggt acagttttaa                                                   20


<210> 23681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23681
accaatgatg aagctgggta                                                   20


<210> 23682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23682
attttaccaa tgatgaagct                                                   20


<210> 23683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23683
tattttacca atgatgaagc                                                   20


<210> 23684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23684
tgcttatttt accaatgatg                                                   20


<210> 23685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23685
taattttcaa acaaccctgt                                                   20


<210> 23686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23686
tgtgtttcag aatcttcttt                                                   20


<210> 23687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23687
agcttatact tattgtgttt                                                   20


<210> 23688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23688
aagaagtaat agctctcatt                                                   20


<210> 23689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23689
taaaagttaa aaagaagtaa                                                   20


<210> 23690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23690
ctaaaataaa agttaaaaag                                                   20


<210> 23691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23691
aacctaaaat aaaagttaaa                                                   20


<210> 23692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23692
taccctcaaa cctaaaataa                                                   20


<210> 23693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23693
aactagattt tttaaaagta                                                   20


<210> 23694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23694
aattaaacta gattttttaa                                                   20


<210> 23695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23695
agacaggttg ccaattaaac                                                   20


<210> 23696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23696
gctggtgttt gtacttagac                                                   20


<210> 23697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23697
agctggtgtt tgtacttaga                                                   20


<210> 23698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23698
aagaagctgg tgtttgtact                                                   20


<210> 23699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23699
ggaaagatat ttcaagaagc                                                   20


<210> 23700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23700
aaagggaaag atatttcaag                                                   20


<210> 23701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23701
agaaaaggga aagatatttc                                                   20


<210> 23702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23702
catatgagga agaaaaggga                                                   20


<210> 23703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23703
aaatcatatg aggaagaaaa                                                   20


<210> 23704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23704
taaatcatat gaggaagaaa                                                   20


<210> 23705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23705
ataaatcata tgaggaagaa                                                   20


<210> 23706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23706
tttaaataaa tcatatgagg                                                   20


<210> 23707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23707
tattttaaat aaatcatatg                                                   20


<210> 23708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23708
gtattttaaa taaatcatat                                                   20


<210> 23709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23709
tttggggagg gcattctcaa                                                   20


<210> 23710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23710
cagaggaaga catttgggga                                                   20


<210> 23711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23711
acagaggaag acatttgggg                                                   20


<210> 23712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23712
aacagaggaa gacatttggg                                                   20


<210> 23713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23713
aaaacagagg aagacatttg                                                   20


<210> 23714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23714
taaaacagag gaagacattt                                                   20


<210> 23715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23715
ctaaaacaga ggaagacatt                                                   20


<210> 23716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23716
caaaatgtct aaaacagagg                                                   20


<210> 23717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23717
gttcaaaatg tctaaaacag                                                   20


<210> 23718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23718
tgttcaaaat gtctaaaaca                                                   20


<210> 23719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23719
cttgttcaaa atgtctaaaa                                                   20


<210> 23720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23720
tacaaaaaaa ttaaagtttg                                                   20


<210> 23721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23721
attacaaaaa aattaaagtt                                                   20


<210> 23722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23722
aggagattac aaaaaaatta                                                   20


<210> 23723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23723
tgactgagaa tttcagagag                                                   20


<210> 23724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23724
tgtgactgag aatttcagag                                                   20


<210> 23725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23725
atgtgactga gaatttcaga                                                   20


<210> 23726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23726
atatgtgact gagaatttca                                                   20


<210> 23727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23727
acatatgtga ctgagaattt                                                   20


<210> 23728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23728
gctgactcac atatgtgact                                                   20


<210> 23729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23729
tgtattccta gtaactaagg                                                   20


<210> 23730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23730
atgtattcct agtaactaag                                                   20


<210> 23731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23731
caatgtattc ctagtaacta                                                   20


<210> 23732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23732
gcaatgtatt cctagtaact                                                   20


<210> 23733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23733
tctaccatgc aatgtattcc                                                   20


<210> 23734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23734
catccaagta gaaatcatga                                                   20


<210> 23735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23735
cttacctgga gtcatccaag                                                   20


<210> 23736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23736
ttccttacct ggagtcatcc                                                   20


<210> 23737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23737
agctctattt tccttacctg                                                   20


<210> 23738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23738
aaagctctat tttccttacc                                                   20


<210> 23739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23739
aacagaaaat gtgatcagaa                                                   20


<210> 23740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23740
tcagaaacag aaaatgtgat                                                   20


<210> 23741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23741
caagtctcaa ctctcagaaa                                                   20


<210> 23742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23742
tcctatcaag tctcaactct                                                   20


<210> 23743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23743
tgtggctttc ctttcctatc                                                   20


<210> 23744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23744
caacctgcag ggacccactg                                                   20


<210> 23745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23745
acactcccca acaacctgca                                                   20


<210> 23746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23746
cacactcccc aacaacctgc                                                   20


<210> 23747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23747
gcacactccc caacaacctg                                                   20


<210> 23748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23748
caggcagagc ctggcattct                                                   20


<210> 23749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23749
ggtaaggagc aggcagagcc                                                   20


<210> 23750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23750
tcctaggtaa ggagcaggca                                                   20


<210> 23751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23751
tgtcctaggt aaggagcagg                                                   20


<210> 23752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23752
gaatgtccta ggtaaggagc                                                   20


<210> 23753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23753
ggaatgtcct aggtaaggag                                                   20


<210> 23754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23754
tgaggaatgt cctaggtaag                                                   20


<210> 23755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23755
cctgaggaat gtcctaggta                                                   20


<210> 23756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23756
ccctgaggaa tgtcctaggt                                                   20


<210> 23757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23757
acaaccctga ggaatgtcct                                                   20


<210> 23758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23758
cacaaccctg aggaatgtcc                                                   20


<210> 23759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23759
tcactgcaaa cacaaccctg                                                   20


<210> 23760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23760
ctcactgcaa acacaaccct                                                   20


<210> 23761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23761
agaccctacc tcatgtctca                                                   20


<210> 23762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23762
gagaccctac ctcatgtctc                                                   20


<210> 23763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23763
caaccctgct ctttgtccca                                                   20


<210> 23764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23764
agcaaccctg ctctttgtcc                                                   20


<210> 23765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23765
ccttttatac caagcaacat                                                   20


<210> 23766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23766
ggaatgcatc cttttatacc                                                   20


<210> 23767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23767
gctgaggaac actgagctta                                                   20


<210> 23768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23768
agctgaggaa cactgagctt                                                   20


<210> 23769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23769
cagctgagga acactgagct                                                   20


<210> 23770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23770
tgtcacagct gaggaacact                                                   20


<210> 23771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23771
gtggattgat gtcacagctg                                                   20


<210> 23772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23772
agtggattga tgtcacagct                                                   20


<210> 23773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23773
catatagtgg attgatgtca                                                   20


<210> 23774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23774
atgagtgtgt acacatatag                                                   20


<210> 23775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23775
tgaatgagtg tgtacacata                                                   20


<210> 23776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23776
ggcattatat gagcctgaat                                                   20


<210> 23777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23777
gtctcatggg ggcattatat                                                   20


<210> 23778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23778
cctttaccca ggtctcatgg                                                   20


<210> 23779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23779
ccctttaccc aggtctcatg                                                   20


<210> 23780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23780
cccctttacc caggtctcat                                                   20


<210> 23781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23781
ccccctttac ccaggtctca                                                   20


<210> 23782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23782
tgttggttcc ccctttaccc                                                   20


<210> 23783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23783
ctgttggttc cccctttacc                                                   20


<210> 23784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23784
gagtttcaac atgtttctgt                                                   20


<210> 23785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23785
ttatgtgtgg aaagtagcat                                                   20


<210> 23786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23786
tgttacttat gtgtggaaag                                                   20


<210> 23787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23787
ctttgttact tatgtgtgga                                                   20


<210> 23788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23788
aggactttgt tacttatgtg                                                   20


<210> 23789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23789
ggtgcttggg tcagagataa                                                   20


<210> 23790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23790
aggtgcttgg gtcagagata                                                   20


<210> 23791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23791
gatatgaggt gcttgggtca                                                   20


<210> 23792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23792
aagatatgag gtgcttgggt                                                   20


<210> 23793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23793
gcagaagata tgaggtgctt                                                   20


<210> 23794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23794
ggcagaagat atgaggtgct                                                   20


<210> 23795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23795
ggatgctggc agaagatatg                                                   20


<210> 23796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23796
tggatgctgg cagaagatat                                                   20


<210> 23797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23797
tgtttcatgg atgctggcag                                                   20


<210> 23798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23798
tactgtttca tggatgctgg                                                   20


<210> 23799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23799
tgatactgtt tcatggatgc                                                   20


<210> 23800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23800
gttgatctga tactgtttca                                                   20


<210> 23801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23801
tactgtactt atatgctaat                                                   20


<210> 23802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23802
ttactgtact tatatgctaa                                                   20


<210> 23803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23803
atagacagtc ttcatgagtt                                                   20


<210> 23804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23804
gcctcataga cagtcttcat                                                   20


<210> 23805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23805
tttgtaactt gcctcataga                                                   20


<210> 23806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23806
gaactttgta acttgcctca                                                   20


<210> 23807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23807
atactaaaaa tagaatactc                                                   20


<210> 23808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23808
aagtttcatt atactaaaaa                                                   20


<210> 23809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23809
ctagctagat ataccactgg                                                   20


<210> 23810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23810
gatctagcta gatataccac                                                   20


<210> 23811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23811
attaggagcc cagatctagc                                                   20


<210> 23812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23812
agccattagg agcccagatc                                                   20


<210> 23813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23813
attagaagcc attaggagcc                                                   20


<210> 23814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23814
gagccattag aagccattag                                                   20


<210> 23815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23815
atgagccatt agaagccatt                                                   20


<210> 23816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23816
gatgagccat tagaagccat                                                   20


<210> 23817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23817
tgacagagat gagccattag                                                   20


<210> 23818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23818
cgctgacaga gatgagccat                                                   20


<210> 23819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23819
ctgctgacgc tgacagagat                                                   20


<210> 23820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23820
ttttcctgct gacgctgaca                                                   20


<210> 23821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23821
atttttcctg ctgacgctga                                                   20


<210> 23822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23822
aagagatcta gtagaattac                                                   20


<210> 23823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23823
gagagttgaa agagatctag                                                   20


<210> 23824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23824
catgagagtt gaaagagatc                                                   20


<210> 23825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23825
agcttccatg agagttgaaa                                                   20


<210> 23826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23826
gcagcttcca tgagagttga                                                   20


<210> 23827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23827
catacaagca gcttccatga                                                   20


<210> 23828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23828
cacatacaag cagcttccat                                                   20


<210> 23829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23829
cattcttgta cacatacaag                                                   20


<210> 23830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23830
tctcattctt gtacacatac                                                   20


<210> 23831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23831
ttttaggata aaagtaggac                                                   20


<210> 23832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23832
ggtagtttta ggataaaagt                                                   20


<210> 23833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23833
tggtagtttt aggataaaag                                                   20


<210> 23834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23834
agatggtagt tttaggataa                                                   20


<210> 23835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23835
ggaaaacaga tggtagtttt                                                   20


<210> 23836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23836
gggaaaacag atggtagttt                                                   20


<210> 23837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23837
taaaaaggga aaacagatgg                                                   20


<210> 23838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23838
ttataaaaag ggaaaacaga                                                   20


<210> 23839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23839
tgtgttataa aaagggaaaa                                                   20


<210> 23840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23840
catcttgtgt gttataaaaa                                                   20


<210> 23841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23841
gcatcttgtg tgttataaaa                                                   20


<210> 23842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23842
agcatcttgt gtgttataaa                                                   20


<210> 23843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23843
gaaagcaagg tcagcttgtg                                                   20


<210> 23844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23844
atactatgag aaagcaaggt                                                   20


<210> 23845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23845
agagatacta tgagaaagca                                                   20


<210> 23846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23846
cagagatact atgagaaagc                                                   20


<210> 23847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23847
tggccagaga tactatgaga                                                   20


<210> 23848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23848
caggtggcca gagatactat                                                   20


<210> 23849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23849
agaacaagta caggtggcca                                                   20


<210> 23850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23850
gaagaacaag tacaggtggc                                                   20


<210> 23851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23851
ggaagaagaa caagtacagg                                                   20


<210> 23852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23852
gtgggaagaa gaacaagtac                                                   20


<210> 23853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23853
ggtgggaaga agaacaagta                                                   20


<210> 23854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23854
agtgtggtgg gaagaagaac                                                   20


<210> 23855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23855
actgcaagtg tggtgggaag                                                   20


<210> 23856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23856
tgaactgcaa gtgtggtggg                                                   20


<210> 23857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23857
tgctgaactg caagtgtggt                                                   20


<210> 23858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23858
ctgctgaact gcaagtgtgg                                                   20


<210> 23859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23859
aaactgctga actgcaagtg                                                   20


<210> 23860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23860
attaaaaact gctgaactgc                                                   20


<210> 23861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23861
taaaacagca tcagatattc                                                   20


<210> 23862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23862
ataaaacagc atcagatatt                                                   20


<210> 23863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23863
aaggaggcat aaaacagcat                                                   20


<210> 23864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23864
aatcgtaagg aggcataaaa                                                   20


<210> 23865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23865
acaagtatac aatcgtaagg                                                   20


<210> 23866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23866
aacaagtata caatcgtaag                                                   20


<210> 23867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23867
ggaacaagta tacaatcgta                                                   20


<210> 23868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23868
gggaacaagt atacaatcgt                                                   20


<210> 23869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23869
caaggcaggc tgaggggaac                                                   20


<210> 23870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23870
gttaggcaag gcaggctgag                                                   20


<210> 23871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23871
agttaggcaa ggcaggctga                                                   20


<210> 23872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23872
tagttaggca aggcaggctg                                                   20


<210> 23873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23873
ctagttaggc aaggcaggct                                                   20


<210> 23874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23874
attttctagt taggcaaggc                                                   20


<210> 23875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23875
aattttctag ttaggcaagg                                                   20


<210> 23876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23876
aggaattttc tagttaggca                                                   20


<210> 23877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23877
caggaatttt ctagttaggc                                                   20


<210> 23878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23878
cgaacaggaa ttttctagtt                                                   20


<210> 23879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23879
acgaacagga attttctagt                                                   20


<210> 23880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23880
aaagacgaac aggaattttc                                                   20


<210> 23881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23881
cagggtctag aaagacgaac                                                   20


<210> 23882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23882
tcagggtcta gaaagacgaa                                                   20


<210> 23883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23883
ggtgcttttc agggtctaga                                                   20


<210> 23884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23884
aaatggtgct tttcagggtc                                                   20


<210> 23885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23885
aacgtaaatg gtgcttttca                                                   20


<210> 23886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23886
aaacgtaaat ggtgcttttc                                                   20


<210> 23887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23887
gaaacgtaaa tggtgctttt                                                   20


<210> 23888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23888
tgcaatttca gaaacgtaaa                                                   20


<210> 23889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23889
agaacaactg cttgcaattt                                                   20


<210> 23890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23890
tgacaaagtt ctgtagcaag                                                   20


<210> 23891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23891
tgtgacaaag ttctgtagca                                                   20


<210> 23892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23892
atgtgacaaa gttctgtagc                                                   20


<210> 23893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23893
gtaaatgtga caaagttctg                                                   20


<210> 23894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23894
agcaaagtgt aaatgtgaca                                                   20


<210> 23895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23895
cttggatgtg tttgtaagca                                                   20


<210> 23896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23896
tagagcttgg atgtgtttgt                                                   20


<210> 23897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23897
aaatgagtaa ctgtagagct                                                   20


<210> 23898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23898
aatacaaatg agtaactgta                                                   20


<210> 23899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23899
agaatacaaa tgagtaactg                                                   20


<210> 23900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23900
gagaagagaa gaatacaaat                                                   20


<210> 23901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23901
ctcagagcaa tggagaagag                                                   20


<210> 23902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23902
gagctcagag caatggagaa                                                   20


<210> 23903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23903
aggagctcag agcaatggag                                                   20


<210> 23904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23904
ttaaggagct cagagcaatg                                                   20


<210> 23905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23905
tcttaaggag ctcagagcaa                                                   20


<210> 23906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23906
gtttattctt aaggagctca                                                   20


<210> 23907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23907
ctgtttattc ttaaggagct                                                   20


<210> 23908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23908
aggtactgtt tattcttaag                                                   20


<210> 23909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23909
ccaggtactg tttattctta                                                   20


<210> 23910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23910
tccaggtact gtttattctt                                                   20


<210> 23911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23911
tgcaaagata aataagatcc                                                   20


<210> 23912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23912
atgcaaagat aaataagatc                                                   20


<210> 23913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23913
ttcacaatgc aaagataaat                                                   20


<210> 23914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23914
tgatcaactt tcacaatgca                                                   20


<210> 23915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23915
gactgttagt tgagtaggac                                                   20


<210> 23916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23916
tagttgactg ttagttgagt                                                   20


<210> 23917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23917
ttagttgact gttagttgag                                                   20


<210> 23918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23918
ctcttagttg actgttagtt                                                   20


<210> 23919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23919
cttgactctt agttgactgt                                                   20


<210> 23920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23920
ccccctgcct tcttgactct                                                   20


<210> 23921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23921
agtaatgttt tgtaccctga                                                   20


<210> 23922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23922
ggagtaatgt tttgtaccct                                                   20


<210> 23923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23923
gcagagaatt ataattcttg                                                   20


<210> 23924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23924
ttgcagagaa ttataattct                                                   20


<210> 23925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23925
cttcaacagt cagtcttgca                                                   20


<210> 23926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23926
agcttcaaca gtcagtcttg                                                   20


<210> 23927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23927
caacaagcag cttcaacagt                                                   20


<210> 23928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23928
gttacaacaa gcagcttcaa                                                   20


<210> 23929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23929
taatttcaag ttacaacaag                                                   20


<210> 23930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23930
aactaatttc aagttacaac                                                   20


<210> 23931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23931
ctatagataa aactaatttc                                                   20


<210> 23932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23932
acaggtttcc tcagaagcta                                                   20


<210> 23933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23933
agtgtaacag gtttcctcag                                                   20


<210> 23934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23934
tagagtgtaa caggtttcct                                                   20


<210> 23935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23935
aattagtcct agagtgtaac                                                   20


<210> 23936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23936
caattagtcc tagagtgtaa                                                   20


<210> 23937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23937
cgttggcaca attagtccta                                                   20


<210> 23938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23938
gtcgttggca caattagtcc                                                   20


<210> 23939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23939
gcaacagtcg ttggcacaat                                                   20


<210> 23940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23940
aactggcgag caacagtcgt                                                   20


<210> 23941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23941
aagctccaac tggcgagcaa                                                   20


<210> 23942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23942
actggtaagc tccaactggc                                                   20


<210> 23943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23943
gggaactggt aagctccaac                                                   20


<210> 23944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23944
taaggatctg gggaactggt                                                   20


<210> 23945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23945
ctagtaagga tctggggaac                                                   20


<210> 23946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23946
ttggccctag taaggatctg                                                   20


<210> 23947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23947
attggcccta gtaaggatct                                                   20


<210> 23948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23948
cattggccct agtaaggatc                                                   20


<210> 23949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23949
aaagttcatt ggccctagta                                                   20


<210> 23950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23950
gaaagttcat tggccctagt                                                   20


<210> 23951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23951
ttgagaaagt tcattggccc                                                   20


<210> 23952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23952
tgctctttga gaaagttcat                                                   20


<210> 23953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23953
ttatatattg ctctttgaga                                                   20


<210> 23954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23954
aatgttatat attgctcttt                                                   20


<210> 23955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23955
gttagaggtt ttattaaaat                                                   20


<210> 23956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23956
ggttagaggt tttattaaaa                                                   20


<210> 23957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23957
gaacaaagag agaaggttag                                                   20


<210> 23958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23958
agaacaaaga gagaaggtta                                                   20


<210> 23959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23959
gtagaacaaa gagagaaggt                                                   20


<210> 23960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23960
ccctgtagaa caaagagaga                                                   20


<210> 23961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23961
tccctgtaga acaaagagag                                                   20


<210> 23962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23962
ctttccctgt agaacaaaga                                                   20


<210> 23963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23963
cactttccct gtagaacaaa                                                   20


<210> 23964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23964
agcactttcc ctgtagaaca                                                   20


<210> 23965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23965
aactgaaagc actttccctg                                                   20


<210> 23966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23966
gagtctgtgg cataaactga                                                   20


<210> 23967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23967
caaaacaggg agagagtctg                                                   20


<210> 23968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23968
cagtttgcaa aacagggaga                                                   20


<210> 23969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23969
atcagtttgc aaaacaggga                                                   20


<210> 23970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23970
atatcagttt gcaaaacagg                                                   20


<210> 23971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 23971
caatatcagt ttgcaaaaca                                                   20


<210> 23972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23972
gcaatatcag tttgcaaaac                                                   20


<210> 23973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23973
ggcaatatca gtttgcaaaa                                                   20


<210> 23974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23974
gagaatttta ctggcaatat                                                   20


<210> 23975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23975
aatagaaaag agaattttac                                                   20


<210> 23976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23976
cagatggcta taatagaaaa                                                   20


<210> 23977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23977
cccagatggc tataatagaa                                                   20


<210> 23978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23978
gaccacccag atggctataa                                                   20


<210> 23979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23979
tgtccaaagg accacccaga                                                   20


<210> 23980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23980
ctgttgtcca aaggaccacc                                                   20


<210> 23981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23981
ccctgaatgc tgttgtccaa                                                   20


<210> 23982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23982
gccctgaatg ctgttgtcca                                                   20


<210> 23983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 23983
actgagcact cctacatgcc                                                   20


<210> 23984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23984
tactgagcac tcctacatgc                                                   20


<210> 23985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23985
gagctcagta aatagttact                                                   20


<210> 23986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23986
ttttacttga gctcagtaaa                                                   20


<210> 23987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23987
gacaaaattt tacttgagct                                                   20


<210> 23988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23988
ccaatgacaa aattttactt                                                   20


<210> 23989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23989
ctagaattaa tccctatgat                                                   20


<210> 23990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 23990
tcatggcaag ttgttttacc                                                   20


<210> 23991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23991
aaagataaaa atatcatggc                                                   20


<210> 23992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23992
gctaaaagat aaaaatatca                                                   20


<210> 23993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23993
tattctttaa aatgagctaa                                                   20


<210> 23994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 23994
aagtcaatat tctttaaaat                                                   20


<210> 23995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23995
cctaagtcaa tatattgatt                                                   20


<210> 23996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 23996
tggtaaatga tctgacacct                                                   20


<210> 23997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23997
cctgctcagc agtggtgccc                                                   20


<210> 23998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 23998
ctcatgatcc tgctcagcag                                                   20


<210> 23999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 23999
gtcctcatga tcctgctcag                                                   20


<210> 24000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24000
attgtcctca tgatcctgct                                                   20


<210> 24001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24001
gttgaacaca gttggtttga                                                   20


<210> 24002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24002
acaagattgt tgaacacagt                                                   20


<210> 24003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24003
tgctacaaga ttgttgaaca                                                   20


<210> 24004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24004
acatcaggaa aacctgctac                                                   20


<210> 24005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24005
gaaaaatctg gtggaacatc                                                   20


<210> 24006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24006
ggaaaaatct ggtggaacat                                                   20


<210> 24007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24007
cagggaaagg aaaaatctgg                                                   20


<210> 24008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24008
agtcagggaa aggaaaaatc                                                   20


<210> 24009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24009
gttaacatag agtcagggaa                                                   20


<210> 24010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24010
agttaacata gagtcaggga                                                   20


<210> 24011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24011
gccaagttaa catagagtca                                                   20


<210> 24012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24012
tgccaagtta acatagagtc                                                   20


<210> 24013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24013
ctgccaagtt aacatagagt                                                   20


<210> 24014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24014
catgctgcca agttaacata                                                   20


<210> 24015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24015
ctcatgctgc caagttaaca                                                   20


<210> 24016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24016
atggaggttc tcatgctgcc                                                   20


<210> 24017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24017
tcttgtcagg ttgtgtatgg                                                   20


<210> 24018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24018
ttcttgtcag gttgtgtatg                                                   20


<210> 24019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24019
ctttcttgtc aggttgtgta                                                   20


<210> 24020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24020
acatgcatgt ctttcttgtc                                                   20


<210> 24021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24021
aacatgcatg tctttcttgt                                                   20


<210> 24022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24022
ttttatttat tctgaatatc                                                   20


<210> 24023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24023
tgagggagta tcacagaaag                                                   20


<210> 24024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24024
ggttgaggga gtatcacaga                                                   20


<210> 24025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24025
atttggttga gggagtatca                                                   20


<210> 24026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24026
ttgaaattat ttggttgagg                                                   20


<210> 24027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24027
tgttgaaatt atttggttga                                                   20


<210> 24028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24028
gtgttgaaat tatttggttg                                                   20


<210> 24029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24029
ggtgttgaaa ttatttggtt                                                   20


<210> 24030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24030
gtataggtgt tgaaattatt                                                   20


<210> 24031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24031
ctatctgaaa ttgcaagtat                                                   20


<210> 24032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24032
tctatctgaa attgcaagta                                                   20


<210> 24033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24033
ttaaatctat ctgaaattgc                                                   20


<210> 24034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24034
agttagaaga tgaaggaagg                                                   20


<210> 24035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24035
caaagttaga agatgaagga                                                   20


<210> 24036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24036
gcaaagttag aagatgaagg                                                   20


<210> 24037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24037
catgcaaagt tagaagatga                                                   20


<210> 24038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24038
tcatgcaaag ttagaagatg                                                   20


<210> 24039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24039
aaaacatcat gcaaagttag                                                   20


<210> 24040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24040
tagaaaacat catgcaaagt                                                   20


<210> 24041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24041
tatttagaaa acatcatgca                                                   20


<210> 24042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24042
aaaactaact aacaactatt                                                   20


<210> 24043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24043
agaagacaag aatacattgt                                                   20


<210> 24044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24044
aattggggat tacagaagac                                                   20


<210> 24045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24045
agagaaattg gggattacag                                                   20


<210> 24046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24046
tgaagagaaa ttggggatta                                                   20


<210> 24047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24047
aggagactga agagaaattg                                                   20


<210> 24048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24048
gaggagactg aagagaaatt                                                   20


<210> 24049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24049
ggaggagact gaagagaaat                                                   20


<210> 24050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24050
agactgtgga ggagactgaa                                                   20


<210> 24051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24051
aaagactgtg gaggagactg                                                   20


<210> 24052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24052
gtggtttaaa gactgtggag                                                   20


<210> 24053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24053
aagtggttta aagactgtgg                                                   20


<210> 24054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24054
aaagtggttt aaagactgtg                                                   20


<210> 24055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24055
tgaaagtggt ttaaagactg                                                   20


<210> 24056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24056
cataaaatga aagtggttta                                                   20


<210> 24057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24057
attcacacat aaaatgaaag                                                   20


<210> 24058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24058
ttcattcaca cataaaatga                                                   20


<210> 24059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24059
ttcatgtcgt cttcagattt                                                   20


<210> 24060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24060
cctaaaattc atgtcgtctt                                                   20


<210> 24061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24061
aaatttatct gtcagaaaag                                                   20


<210> 24062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24062
gaaaaattta tctgtcagaa                                                   20


<210> 24063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24063
gactagaaaa atttatctgt                                                   20


<210> 24064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24064
aagtatctaa aattatagac                                                   20


<210> 24065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24065
agtggaagta tctaaaatta                                                   20


<210> 24066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24066
tttttaccat agaggagtgg                                                   20


<210> 24067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24067
gggtttttac catagaggag                                                   20


<210> 24068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24068
agagggtttt taccatagag                                                   20


<210> 24069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24069
tcagagggtt tttaccatag                                                   20


<210> 24070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24070
ttcagagggt ttttaccata                                                   20


<210> 24071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24071
atttcagagg gtttttacca                                                   20


<210> 24072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24072
ttagaaaggt gtatttcaga                                                   20


<210> 24073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24073
tttagaaagg tgtatttcag                                                   20


<210> 24074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24074
gtttagaaag gtgtatttca                                                   20


<210> 24075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24075
ttgtttagaa aggtgtattt                                                   20


<210> 24076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24076
tttctcaata ttgtttagaa                                                   20


<210> 24077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24077
ttttctcaat attgtttaga                                                   20


<210> 24078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24078
ctaattttct caatattgtt                                                   20


<210> 24079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24079
tcttttgaac ttaatttcag                                                   20


<210> 24080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24080
tttcttttga acttaatttc                                                   20


<210> 24081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24081
gtttcttttg aacttaattt                                                   20


<210> 24082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24082
ctggatcttc taatcaagat                                                   20


<210> 24083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24083
ttcatctgga tcttctaatc                                                   20


<210> 24084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24084
atacttgaaa cagtttcatc                                                   20


<210> 24085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24085
ttaacttaga atacttgaaa                                                   20


<210> 24086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24086
agtcacattt gtttttaact                                                   20


<210> 24087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24087
attttgtaca taaaaattta                                                   20


<210> 24088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24088
caattttcaa ttttttgtag                                                   20


<210> 24089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24089
gtacaatttt caattttttg                                                   20


<210> 24090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24090
gaataaacct aaccattttt                                                   20


<210> 24091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24091
aacaagggtt tgatggacaa                                                   20


<210> 24092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24092
gatacgtaac aagggtttga                                                   20


<210> 24093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24093
acataaaaga tacgtaacaa                                                   20


<210> 24094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24094
tacataaaag atacgtaaca                                                   20


<210> 24095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24095
atacataaaa gatacgtaac                                                   20


<210> 24096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24096
gtacagaggt gaatacataa                                                   20


<210> 24097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24097
ggaaaggaaa tcatgtacag                                                   20


<210> 24098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24098
aggaaaggaa atcatgtaca                                                   20


<210> 24099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24099
tgaggaaagg aaatcatgta                                                   20


<210> 24100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24100
aacataaatt cactgaggaa                                                   20


<210> 24101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24101
taacataaat tcactgagga                                                   20


<210> 24102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24102
aacctaacat aaattcactg                                                   20


<210> 24103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24103
aaacctaaca taaattcact                                                   20


<210> 24104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24104
ttagttgcca tatctagtta                                                   20


<210> 24105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24105
gtcactttag ttgccatatc                                                   20


<210> 24106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24106
accctgacta tctgtcactt                                                   20


<210> 24107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24107
tctcaagaaa taagccaggt                                                   20


<210> 24108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24108
tctttctcaa gaaataagcc                                                   20


<210> 24109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24109
ctctttctca agaaataagc                                                   20


<210> 24110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24110
atctctcttt ctcaagaaat                                                   20


<210> 24111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24111
tctactgatc tctctttctc                                                   20


<210> 24112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24112
caggctccat ctcttctagg                                                   20


<210> 24113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24113
acccaggctc catctcttct                                                   20


<210> 24114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24114
aacccaggct ccatctcttc                                                   20


<210> 24115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24115
ctgatatttt gattcaaccc                                                   20


<210> 24116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24116
actgatattt tgattcaacc                                                   20


<210> 24117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24117
gcataacaat ttttgctgcc                                                   20


<210> 24118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24118
cttgcatcac aattctaaac                                                   20


<210> 24119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24119
ataatctgac caatttttct                                                   20


<210> 24120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24120
agccaaactc cttaaggtaa                                                   20


<210> 24121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24121
aagccaaact ccttaaggta                                                   20


<210> 24122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24122
gatataagcc aaactcctta                                                   20


<210> 24123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24123
ggatataagc caaactcctt                                                   20


<210> 24124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24124
cctcaacctc aataggatat                                                   20


<210> 24125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24125
acttactcct caacctcaat                                                   20


<210> 24126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24126
tacttactcc tcaacctcaa                                                   20


<210> 24127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24127
cttatcctcc atgtaccgtg                                                   20


<210> 24128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24128
aacttatcct ccatgtaccg                                                   20


<210> 24129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24129
cagaatccaa atggttttct                                                   20


<210> 24130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24130
ccagaatcca aatggttttc                                                   20


<210> 24131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24131
atactggacc agaatccaaa                                                   20


<210> 24132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24132
ctccagacag gatactggac                                                   20


<210> 24133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24133
tttccctcca gacaggatac                                                   20


<210> 24134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24134
actaatcttt ccctccagac                                                   20


<210> 24135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24135
aactaatctt tccctccaga                                                   20


<210> 24136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24136
tcctaactaa tctttccctc                                                   20


<210> 24137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24137
tcttgaatct gttacaactc                                                   20


<210> 24138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24138
aacatccacc tggtagtcct                                                   20


<210> 24139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24139
taacatccac ctggtagtcc                                                   20


<210> 24140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24140
cactgctaac atccacctgg                                                   20


<210> 24141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24141
attcactgct aacatccacc                                                   20


<210> 24142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24142
cgagtcagct cctcctcctg                                                   20


<210> 24143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24143
aaaatcatta cctgccgagt                                                   20


<210> 24144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24144
tctcaaaatc attacctgcc                                                   20


<210> 24145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24145
tctgtattta aacaattcac                                                   20


<210> 24146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24146
atctgtattt aaacaattca                                                   20


<210> 24147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24147
cccccatttt taaaatctat                                                   20


<210> 24148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24148
acccccattt ttaaaatcta                                                   20


<210> 24149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24149
agacaggttt ttcccgtttc                                                   20


<210> 24150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24150
tagacaggtt tttcccgttt                                                   20


<210> 24151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24151
ctaagaattc ttttctagac                                                   20


<210> 24152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24152
actaagaatt cttttctaga                                                   20


<210> 24153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24153
tattactaag aattcttttc                                                   20


<210> 24154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24154
catgtatgct aattattact                                                   20


<210> 24155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24155
aaaaactgtt ctgacttcag                                                   20


<210> 24156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24156
ctcaaaaact gttctgactt                                                   20


<210> 24157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24157
gtttcagaat gtttcggagt                                                   20


<210> 24158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24158
tgttgtttca gaatgtttcg                                                   20


<210> 24159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 24159
attgttgttt cagaatgttt                                                   20


<210> 24160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24160
ctcccttaat attgttgttt                                                   20


<210> 24161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24161
gaattggtat ggtctgcttt                                                   20


<210> 24162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24162
tttaacaaca agaattggta                                                   20


<210> 24163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24163
gacagtttaa caacaagaat                                                   20


<210> 24164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24164
atttctgaca gtttaacaac                                                   20


<210> 24165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24165
agacaagcag gaatttctga                                                   20


<210> 24166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24166
gcttttaaca acagacaagc                                                   20


<210> 24167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24167
tgcttttaac aacagacaag                                                   20


<210> 24168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24168
ggctgctttt aacaacagac                                                   20


<210> 24169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24169
ataatggctg cttttaacaa                                                   20


<210> 24170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24170
tatagtcaaa tatttaataa                                                   20


<210> 24171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24171
tatagaattc taagtttata                                                   20


<210> 24172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24172
aaggtaagtt atagaattct                                                   20


<210> 24173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24173
cctttcctta aggtaagtta                                                   20


<210> 24174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24174
ttattacctt tccttaaggt                                                   20


<210> 24175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24175
gtatttatta cctttcctta                                                   20


<210> 24176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24176
agtatttatt acctttcctt                                                   20


<210> 24177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24177
aattaggaag tgatatgtct                                                   20


<210> 24178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24178
aatacagtaa aataattagg                                                   20


<210> 24179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24179
taaaatacag taaaataatt                                                   20


<210> 24180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24180
ataaaataca gtaaaataat                                                   20


<210> 24181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24181
cggaatagac aaataaaata                                                   20


<210> 24182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24182
cttctgctat tcaaacggaa                                                   20


<210> 24183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 24183
ccatacttct gctattcaaa                                                   20


<210> 24184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24184
agagatgcac aatagcccga                                                   20


<210> 24185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24185
cagaaagaag agatgcacaa                                                   20


<210> 24186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24186
agaccaccgt ccagaaagaa                                                   20


<210> 24187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24187
atagaccacc gtccagaaag                                                   20


<210> 24188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24188
agaatagacc accgtccaga                                                   20


<210> 24189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24189
agagagaata gaccaccgtc                                                   20


<210> 24190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24190
agagaataat ccagagagaa                                                   20


<210> 24191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24191
tccagagaga ataatccaga                                                   20


<210> 24192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24192
tgtccagaga gaataatcca                                                   20


<210> 24193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24193
actgtccaga gagaataatc                                                   20


<210> 24194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24194
gcatattact actgtccaga                                                   20


<210> 24195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24195
tagcatatta ctactgtcca                                                   20


<210> 24196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24196
tatagcatat tactactgtc                                                   20


<210> 24197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24197
tgcacagtag cccaatagta                                                   20


<210> 24198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24198
agagttgcac agtagcccaa                                                   20


<210> 24199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24199
cagaaagaag agttgcacag                                                   20


<210> 24200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24200
atccagaaag aagagttgca                                                   20


<210> 24201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24201
agaccagcat ccagaaagaa                                                   20


<210> 24202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24202
atagaccagc atccagaaag                                                   20


<210> 24203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24203
agaatagacc agcatccaga                                                   20


<210> 24204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24204
agatagaata gaccagcatc                                                   20


<210> 24205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24205
ataggccaga tagaatagac                                                   20


<210> 24206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24206
atagaatagg ccagatagaa                                                   20


<210> 24207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24207
tccagataga ataggccaga                                                   20


<210> 24208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24208
accatccaga tagaataggc                                                   20


<210> 24209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24209
ttccaccatc cagatagaat                                                   20


<210> 24210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24210
cttccaccat ccagatagaa                                                   20


<210> 24211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24211
acatacttcc accatccaga                                                   20


<210> 24212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24212
tgtgacatac ttccaccatc                                                   20


<210> 24213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24213
agagattcac agtagctcaa                                                   20


<210> 24214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24214
agttaagaag agattcacag                                                   20


<210> 24215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24215
cagagttaag aagagattca                                                   20


<210> 24216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24216
gctaaatgca gagttaagaa                                                   20


<210> 24217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24217
ttgctaaatg cagagttaag                                                   20


<210> 24218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24218
aaattgctaa atgcagagtt                                                   20


<210> 24219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24219
atgtgaaatt gctaaatgca                                                   20


<210> 24220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24220
tgatgtgaaa ttgctaaatg                                                   20


<210> 24221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24221
ttggagattt ttgtaatgta                                                   20


<210> 24222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24222
gctctcattt gtagtgcttg                                                   20


<210> 24223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24223
aagctctcat ttgtagtgct                                                   20


<210> 24224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24224
aatcaagaag ctctcatttg                                                   20


<210> 24225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24225
ttctactcta gaaaatcaag                                                   20


<210> 24226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24226
taattctact ctagaaaatc                                                   20


<210> 24227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24227
tcaccttctt aattctactc                                                   20


<210> 24228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24228
tgactgttta tctgttttat                                                   20


<210> 24229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24229
ttttgtgcta ttcagagtaa                                                   20


<210> 24230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24230
tttaattttt gtgctattca                                                   20


<210> 24231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24231
tttttaattt ttgtgctatt                                                   20


<210> 24232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24232
aacagaattt caataatgaa                                                   20


<210> 24233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24233
aaacagaatt tcaataatga                                                   20


<210> 24234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24234
attatttgca aatcaaaaaa                                                   20


<210> 24235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24235
tactcattca tcagtgatgt                                                   20


<210> 24236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24236
tcagaacttt actcattcat                                                   20


<210> 24237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24237
gaaatgaaga agctatatgt                                                   20


<210> 24238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24238
gaaataaaaa agaaatgaag                                                   20


<210> 24239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24239
agtgaaataa aaaagaaatg                                                   20


<210> 24240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24240
tgttagtcag tgaaataaaa                                                   20


<210> 24241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24241
tgcttgatat ttatgttagt                                                   20


<210> 24242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24242
agactgcttg atatttatgt                                                   20


<210> 24243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24243
acaagtatag ttttagcatg                                                   20


<210> 24244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24244
ctaataaaca agtatagttt                                                   20


<210> 24245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24245
ttgcagctaa taaacaagta                                                   20


<210> 24246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24246
tatttttgca gctaataaac                                                   20


<210> 24247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24247
gtataggcaa cctatttttg                                                   20


<210> 24248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24248
tgccaaactt ttgcatgtat                                                   20


<210> 24249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24249
ttgccaaact tttgcatgta                                                   20


<210> 24250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24250
gtatatcaaa ttgtttctca                                                   20


<210> 24251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24251
ctataaattt tactgatatt                                                   20


<210> 24252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24252
actataaatt ttactgatat                                                   20


<210> 24253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24253
ttttataaac tggttctcca                                                   20


<210> 24254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24254
tttttataaa ctggttctcc                                                   20


<210> 24255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24255
aggtaaatat ttttataaac                                                   20


<210> 24256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24256
tacctgtcct agtgatgtgt                                                   20


<210> 24257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24257
ctacctgtcc tagtgatgtg                                                   20


<210> 24258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24258
gttttctcct ctacctgtcc                                                   20


<210> 24259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24259
ctctcatttc atctacttca                                                   20


<210> 24260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24260
tctcttttac tgcaccctct                                                   20


<210> 24261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24261
ttataaaact ttttactctt                                                   20


<210> 24262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24262
ttctgggcct cttatgttca                                                   20


<210> 24263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24263
gtttcaatca ttctctttct                                                   20


<210> 24264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24264
tgtttcaatc attctctttc                                                   20


<210> 24265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24265
tcttttcttc agagtaattc                                                   20


<210> 24266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24266
aagagtctct cttttcttca                                                   20


<210> 24267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24267
taaagagtct ctcttttctt                                                   20


<210> 24268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24268
cactgtagtt actttttaaa                                                   20


<210> 24269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24269
ttcactgtag ttacttttta                                                   20


<210> 24270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24270
ttatgaggaa gaattcactg                                                   20


<210> 24271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24271
tcatctaaaa ttttatgagg                                                   20


<210> 24272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24272
ttttcatcta aaattttatg                                                   20


<210> 24273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24273
tttttcatct aaaattttat                                                   20


<210> 24274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24274
tcctgccttc atctaaaatg                                                   20


<210> 24275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24275
ctcctgcctt catctaaaat                                                   20


<210> 24276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24276
ttctgaaaca ggtatcaaaa                                                   20


<210> 24277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24277
aaaattcaaa cttctgaaac                                                   20


<210> 24278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24278
taaaattcaa acttctgaaa                                                   20


<210> 24279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24279
agaaaaggag atcaatcttt                                                   20


<210> 24280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24280
tatattgttt tacagaaaag                                                   20


<210> 24281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24281
attatattgt tttacagaaa                                                   20


<210> 24282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24282
aattatattg ttttacagaa                                                   20


<210> 24283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24283
taatgaatta tattgtttta                                                   20


<210> 24284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24284
atacaactta tgattatctg                                                   20


<210> 24285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24285
ggattctagt tttgttgttt                                                   20


<210> 24286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24286
gcatcttgtc aagaggattc                                                   20


<210> 24287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24287
accaggtgca tcttgtcaag                                                   20


<210> 24288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24288
taccaggtgc atcttgtcaa                                                   20


<210> 24289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24289
tctaccaggt gcatcttgtc                                                   20


<210> 24290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24290
attacaaaac attttctacc                                                   20


<210> 24291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24291
cattacaaaa cattttctac                                                   20


<210> 24292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24292
ttagacttca gaaacatgaa                                                   20


<210> 24293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24293
tcaatgcact aattagactt                                                   20


<210> 24294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24294
aactggatca atgcactaat                                                   20


<210> 24295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24295
gaaaataacc ttatatcaac                                                   20


<210> 24296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24296
agagctggaa attaaagtgc                                                   20


<210> 24297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24297
ttctatagag ctggaaatta                                                   20


<210> 24298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24298
ttgctgtatt tctatagagc                                                   20


<210> 24299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24299
ttgtttgctg tatttctata                                                   20


<210> 24300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24300
ccttgtttgc tgtatttcta                                                   20


<210> 24301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24301
accagagaca tagggggaga                                                   20


<210> 24302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24302
caccagagac atagggggag                                                   20


<210> 24303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24303
acaccagaga cataggggga                                                   20


<210> 24304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24304
aaacaccaga gacatagggg                                                   20


<210> 24305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24305
aaaaacacca gagacatagg                                                   20


<210> 24306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24306
caaaaacacc agagacatag                                                   20


<210> 24307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24307
acaaaaacac cagagacata                                                   20


<210> 24308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24308
aacaaaaaca ccagagacat                                                   20


<210> 24309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24309
taacaaaaac accagagaca                                                   20


<210> 24310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24310
acatgataac aaaaacacca                                                   20


<210> 24311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24311
atacatgata acaaaaacac                                                   20


<210> 24312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24312
aacttccaga gagaaaaaac                                                   20


<210> 24313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24313
aaacttccag agagaaaaaa                                                   20


<210> 24314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24314
ggaacttaga aacttccaga                                                   20


<210> 24315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24315
tgggaactta gaaacttcca                                                   20


<210> 24316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24316
tctgggaact tagaaacttc                                                   20


<210> 24317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24317
gtttgagtct tctgggaact                                                   20


<210> 24318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24318
agactcagtt tgagtcttct                                                   20


<210> 24319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24319
cagactcagt ttgagtcttc                                                   20


<210> 24320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24320
aagcattaca gactcagttt                                                   20


<210> 24321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24321
aagagcaagc attacagact                                                   20


<210> 24322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24322
agcacaaaga gcaagcatta                                                   20


<210> 24323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24323
gtactataag cacaaagagc                                                   20


<210> 24324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24324
atgagtacta taagcacaaa                                                   20


<210> 24325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24325
tgatgagtac tataagcaca                                                   20


<210> 24326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24326
aggactatga tgagtactat                                                   20


<210> 24327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24327
gccaagtaga ggactatgat                                                   20


<210> 24328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24328
tgacctatta agccaagtag                                                   20


<210> 24329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24329
atgacctatt aagccaagta                                                   20


<210> 24330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24330
aaatgaccta ttaagccaag                                                   20


<210> 24331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24331
tataaatgac ctattaagcc                                                   20


<210> 24332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24332
tcaactataa atgacctatt                                                   20


<210> 24333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24333
ataactcttt ttggggaatc                                                   20


<210> 24334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24334
agattatata actctttttg                                                   20


<210> 24335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24335
aagattatat aactcttttt                                                   20


<210> 24336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24336
gaagattata taactctttt                                                   20


<210> 24337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24337
aattatgact aactgcttag                                                   20


<210> 24338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24338
tcaaattatg actaactgct                                                   20


<210> 24339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24339
tgtaaagtat agaattcaca                                                   20


<210> 24340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24340
tatgtaaagt atagaattca                                                   20


<210> 24341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24341
tccaatgttt atgtaaagta                                                   20


<210> 24342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24342
tttcatccaa tgtttatgta                                                   20


<210> 24343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24343
tgtataaatg aagctatgtg                                                   20


<210> 24344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24344
taattaacat tgtataaatg                                                   20


<210> 24345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24345
tgatacataa tttcagatct                                                   20


<210> 24346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24346
tataggatga tacataattt                                                   20


<210> 24347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24347
gataataatt atttaagtat                                                   20


<210> 24348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24348
agataataat tatttaagta                                                   20


<210> 24349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24349
catgtagata ataattattt                                                   20


<210> 24350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24350
ctctcttaac taaatgcatg                                                   20


<210> 24351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24351
ccctgaaaaa gattaactta                                                   20


<210> 24352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24352
ttccctgaaa aagattaact                                                   20


<210> 24353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24353
tatttttatt ttccctgaaa                                                   20


<210> 24354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24354
ctcatttttt tcgctctctc                                                   20


<210> 24355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24355
aagacaaatt ctaaagcact                                                   20


<210> 24356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24356
taagtttaag acaaattcta                                                   20


<210> 24357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24357
tgatcattgt ttttaagttt                                                   20


<210> 24358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24358
tatatgtgat cattgttttt                                                   20


<210> 24359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24359
ccaataattt gcccctgaga                                                   20


<210> 24360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24360
ttatccaata atttgcccct                                                   20


<210> 24361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24361
gcaaaatctt cttaaccaaa                                                   20


<210> 24362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24362
agcaaaatct tcttaaccaa                                                   20


<210> 24363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24363
gagcaaaatc ttcttaacca                                                   20


<210> 24364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24364
tgacaaaagt aaatcccaga                                                   20


<210> 24365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24365
attgacaaaa gtaaatccca                                                   20


<210> 24366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24366
agattgacaa aagtaaatcc                                                   20


<210> 24367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24367
ttcaatttta agattgacaa                                                   20


<210> 24368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24368
taatgtttcc cttcaatttt                                                   20


<210> 24369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24369
gtttttattt cctcaatcat                                                   20


<210> 24370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24370
acttttctaa ttaggatttt                                                   20


<210> 24371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24371
gtttactaac ttttctaatt                                                   20


<210> 24372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24372
agtttactaa cttttctaat                                                   20


<210> 24373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24373
gaaacttcat ttcagattga                                                   20


<210> 24374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24374
atatttatga aacttcattt                                                   20


<210> 24375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24375
tgaggtgtaa taaaccctga                                                   20


<210> 24376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24376
ctgaggtgta ataaaccctg                                                   20


<210> 24377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24377
tctgaggtgt aataaaccct                                                   20


<210> 24378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24378
taagagaaag aaactctctg                                                   20


<210> 24379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24379
ataagagaaa gaaactctct                                                   20


<210> 24380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24380
tcttgcctca aaataagaga                                                   20


<210> 24381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24381
tcactcttgc ctcaaaataa                                                   20


<210> 24382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24382
catcactctt gcctcaaaat                                                   20


<210> 24383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24383
cctttgcaca aaaaccagac                                                   20


<210> 24384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24384
acctttgcac aaaaaccaga                                                   20


<210> 24385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24385
atataccttt gcacaaaaac                                                   20


<210> 24386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24386
agcttagttg gaaatctctt                                                   20


<210> 24387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24387
cagcttagtt ggaaatctct                                                   20


<210> 24388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24388
acattgctaa ccagcttagt                                                   20


<210> 24389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24389
gataacattg ctaaccagct                                                   20


<210> 24390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24390
ggtatgataa cattgctaac                                                   20


<210> 24391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24391
taatagtcct tttaaagaga                                                   20


<210> 24392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24392
ttaatagtcc ttttaaagag                                                   20


<210> 24393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24393
caattaatag tccttttaaa                                                   20


<210> 24394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24394
ttcaattaat agtcctttta                                                   20


<210> 24395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24395
ttatgtttac attcaattaa                                                   20


<210> 24396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24396
ggacccatta aaatgtttga                                                   20


<210> 24397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24397
tgggacccat taaaatgttt                                                   20


<210> 24398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24398
agaaatagca tttactcact                                                   20


<210> 24399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24399
aagaaatagc atttactcac                                                   20


<210> 24400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24400
gtgaaaccac ccaaaagaaa                                                   20


<210> 24401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24401
acattagtga aaccacccaa                                                   20


<210> 24402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24402
aatgcaccat gagagcacat                                                   20


<210> 24403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24403
ctttatgtaa tgcaccatga                                                   20


<210> 24404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24404
gactttatgt aatgcaccat                                                   20


<210> 24405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24405
taacatgatg aaactcagca                                                   20


<210> 24406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24406
tggtttaaca tgatgaaact                                                   20


<210> 24407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24407
tttttttttt ttgagagctt                                                   20


<210> 24408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24408
tttttttttt ttttttttga                                                   20


<210> 24409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24409
tttttttttt tttttttttt                                                   20


<210> 24410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24410
ctgtcttttg aagtggtcag                                                   20


<210> 24411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24411
agtctgtctt ttgaagtggt                                                   20


<210> 24412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24412
gaatagtctg tcttttgaag                                                   20


<210> 24413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24413
aatgaatagt ctgtcttttg                                                   20


<210> 24414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24414
ctgttatggt ttttaatgaa                                                   20


<210> 24415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24415
ttatattgat catgctgtta                                                   20


<210> 24416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24416
atgttaagaa atggtgaaaa                                                   20


<210> 24417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24417
ttatatttga tgttaagaaa                                                   20


<210> 24418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24418
ttttagttat atttgatgtt                                                   20


<210> 24419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24419
atgttaacaa atatttgttt                                                   20


<210> 24420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24420
tattttttct ttcttttgga                                                   20


<210> 24421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24421
cttttatttt ttctttcttt                                                   20


<210> 24422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24422
ctaataatta attctaactt                                                   20


<210> 24423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24423
ttctgttaac ttggtaggag                                                   20


<210> 24424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24424
tttttctgtt aacttggtag                                                   20


<210> 24425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24425
tatttttctg ttaacttggt                                                   20


<210> 24426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24426
gtatttttct gttaacttgg                                                   20


<210> 24427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24427
aatgtatttt tctgttaact                                                   20


<210> 24428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24428
aaaaataata atggtaataa                                                   20


<210> 24429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24429
tctgtctcaa aaaataataa                                                   20


<210> 24430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24430
ctccagcctg gcaacaaagt                                                   20


<210> 24431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24431
tgcactccag cctggcaaca                                                   20


<210> 24432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24432
cctgctactg cactccagcc                                                   20


<210> 24433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24433
gagatcctgc tactgcactc                                                   20


<210> 24434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24434
ggcagaggtt gcagtgagct                                                   20


<210> 24435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24435
caggaggcag aggttgcagt                                                   20


<210> 24436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24436
aacccaggag gcagaggttg                                                   20


<210> 24437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24437
cgcttgaacc caggaggcag                                                   20


<210> 24438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24438
tcgcttgaac ccaggaggca                                                   20


<210> 24439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24439
aatcgcttga acccaggagg                                                   20


<210> 24440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24440
gagaatcgct tgaacccagg                                                   20


<210> 24441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24441
ggagaatcgc ttgaacccag                                                   20


<210> 24442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24442
caggagaatc gcttgaaccc                                                   20


<210> 24443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24443
gcaggagaat cgcttgaacc                                                   20


<210> 24444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24444
tactcaagag gctgaggcag                                                   20


<210> 24445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24445
gctactcaag aggctgaggc                                                   20


<210> 24446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24446
agctactcaa gaggctgagg                                                   20


<210> 24447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24447
cccagctact caagaggctg                                                   20


<210> 24448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24448
tcccagctac tcaagaggct                                                   20


<210> 24449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24449
tgtagtccca gctactcaag                                                   20


<210> 24450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24450
ctgtagtccc agctactcaa                                                   20


<210> 24451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24451
gcctgtagtc ccagctactc                                                   20


<210> 24452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24452
gtggtgagcg cctgtagtcc                                                   20


<210> 24453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24453
agcctggtgg tgagcgcctg                                                   20


<210> 24454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24454
aattagctga gcctggtggt                                                   20


<210> 24455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24455
caaaaattag ctgagcctgg                                                   20


<210> 24456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24456
atacaaaaat tagctgagcc                                                   20


<210> 24457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24457
taaaaataca aaaattagct                                                   20


<210> 24458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24458
tctactaaaa atacaaaaat                                                   20


<210> 24459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24459
cgagaccatc ctggctaaca                                                   20


<210> 24460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24460
tcaagagatc gagaccatcc                                                   20


<210> 24461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24461
tttcacaagg tcaagagatc                                                   20


<210> 24462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24462
aacctttttc acaaggtcaa                                                   20


<210> 24463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24463
ataacctttt tcacaaggtc                                                   20


<210> 24464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24464
gaaaaataac ctttttcaca                                                   20


<210> 24465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24465
cgaaaaataa cctttttcac                                                   20


<210> 24466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24466
tacataatca ggattagagt                                                   20


<210> 24467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24467
aaattacata atcaggatta                                                   20


<210> 24468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24468
gtaaattaca taatcaggat                                                   20


<210> 24469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24469
aattagtaaa ttacataatc                                                   20


<210> 24470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24470
aaattagtaa attacataat                                                   20


<210> 24471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24471
ctgcttttag attatcaaat                                                   20


<210> 24472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24472
gttttatatt gtgctgcttt                                                   20


<210> 24473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24473
catgactctt tgggtctatg                                                   20


<210> 24474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24474
tgaacatgac atgactcttt                                                   20


<210> 24475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24475
atgaacatga catgactctt                                                   20


<210> 24476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24476
atccttagtt ctacatgact                                                   20


<210> 24477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24477
gccctgttct ttactatcct                                                   20


<210> 24478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24478
tactttgtat ttgaagactt                                                   20


<210> 24479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24479
tgtctattac tttgtatttg                                                   20


<210> 24480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24480
tcttatgcaa ggttgttcct                                                   20


<210> 24481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24481
ttttctctcc ctcttatgca                                                   20


<210> 24482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24482
cttttctctc cctcttatgc                                                   20


<210> 24483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24483
tgtatttcat tgattgcatc                                                   20


<210> 24484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24484
tcacatttgt tgattcattt                                                   20


<210> 24485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24485
taaaacgatt ttgttgttca                                                   20


<210> 24486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24486
caagtagcat gtttttactg                                                   20


<210> 24487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24487
gaaaaagaat taaatccaag                                                   20


<210> 24488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24488
tatgaaaaag aattaaatcc                                                   20


<210> 24489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24489
aaattaaatg aagtatgaaa                                                   20


<210> 24490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24490
gtaacagaaa aaattaaatg                                                   20


<210> 24491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24491
ctctgctacc tgaaaggtaa                                                   20


<210> 24492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24492
agagatctct gctacctgaa                                                   20


<210> 24493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24493
cagagatctc tgctacctga                                                   20


<210> 24494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24494
agagcaatgt ttcacctcca                                                   20


<210> 24495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24495
tcagagcaat gtttcacctc                                                   20


<210> 24496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24496
ctagaatcaa tgccagttca                                                   20


<210> 24497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24497
ggctagaatc aatgccagtt                                                   20


<210> 24498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24498
agctgggcta gaatcaatgc                                                   20


<210> 24499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24499
ttggtctaca agagctgggc                                                   20


<210> 24500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24500
gtaattggtc tacaagagct                                                   20


<210> 24501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24501
ggtaattggt ctacaagagc                                                   20


<210> 24502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24502
agttggtaat tggtctacaa                                                   20


<210> 24503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24503
caagttggta attggtctac                                                   20


<210> 24504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24504
tttacttaca agttggtaat                                                   20


<210> 24505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24505
gaacatgttt acttacaagt                                                   20


<210> 24506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24506
tcatgaacat gtttacttac                                                   20


<210> 24507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24507
agcatgggct tgtcagaatg                                                   20


<210> 24508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24508
actgagaagc atgggcttgt                                                   20


<210> 24509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24509
acatgaagac tgagaagcat                                                   20


<210> 24510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24510
cacatgaaga ctgagaagca                                                   20


<210> 24511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24511
gtttccacat gaagactgag                                                   20


<210> 24512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24512
atagtttcca catgaagact                                                   20


<210> 24513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24513
aaatgcatag tttccacatg                                                   20


<210> 24514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24514
gcttaaaaac tggaaatgca                                                   20


<210> 24515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24515
aacattgggt gcttaaaaac                                                   20


<210> 24516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24516
ttgttgatgg attgaacatt                                                   20


<210> 24517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24517
tttgttgatg gattgaacat                                                   20


<210> 24518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24518
gagctgaagg gatttgttga                                                   20


<210> 24519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24519
attttgaagt tagagctgaa                                                   20


<210> 24520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24520
tattttgaag ttagagctga                                                   20


<210> 24521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24521
atattttgaa gttagagctg                                                   20


<210> 24522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24522
ctgagtatat tttgaagtta                                                   20


<210> 24523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24523
tgctgagtat attttgaagt                                                   20


<210> 24524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24524
gacatgctga gtatattttg                                                   20


<210> 24525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24525
tagtgagggt gtgacatgct                                                   20


<210> 24526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24526
ggtagagttt tgtatagtga                                                   20


<210> 24527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24527
tggtagagtt ttgtatagtg                                                   20


<210> 24528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24528
atggtagagt tttgtatagt                                                   20


<210> 24529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24529
tagtatggta gagttttgta                                                   20


<210> 24530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24530
gagcttagac tagtatggta                                                   20


<210> 24531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24531
gggagcttag actagtatgg                                                   20


<210> 24532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24532
gatgggagct tagactagta                                                   20


<210> 24533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24533
gaggtgatgg gagcttagac                                                   20


<210> 24534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24534
ggtgagaggt gatgggagct                                                   20


<210> 24535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24535
atccaggtga gaggtgatgg                                                   20


<210> 24536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24536
aaatccaggt gagaggtgat                                                   20


<210> 24537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24537
taaatccagg tgagaggtga                                                   20


<210> 24538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24538
tctgcataaa tccaggtgag                                                   20


<210> 24539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24539
ttctgcataa atccaggtga                                                   20


<210> 24540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24540
gtttctgcat aaatccaggt                                                   20


<210> 24541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24541
tggagtttct gcataaatcc                                                   20


<210> 24542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24542
ttggagtttc tgcataaatc                                                   20


<210> 24543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24543
agaagctgga agatttcttg                                                   20


<210> 24544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24544
gcagaagctg gaagatttct                                                   20


<210> 24545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24545
atagcaatgg cagaagctgg                                                   20


<210> 24546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24546
cgaatagcaa tggcagaagc                                                   20


<210> 24547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24547
agggcgaata gcaatggcag                                                   20


<210> 24548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24548
ggaagggcga atagcaatgg                                                   20


<210> 24549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24549
agtggaaggg cgaatagcaa                                                   20


<210> 24550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24550
cttaagagtg gaagggcgaa                                                   20


<210> 24551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24551
gtgcaatctt aagagtggaa                                                   20


<210> 24552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24552
tgtgcaatct taagagtgga                                                   20


<210> 24553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24553
atgtgcaatc ttaagagtgg                                                   20


<210> 24554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24554
acaatgtgca atcttaagag                                                   20


<210> 24555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24555
ctcacaatgt gcaatcttaa                                                   20


<210> 24556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24556
atctcacaat gtgcaatctt                                                   20


<210> 24557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24557
gacatttgaa gaacattata                                                   20


<210> 24558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24558
agacatttga agaacattat                                                   20


<210> 24559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24559
gccagattat aagacatttg                                                   20


<210> 24560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24560
tgtagtagag gccagattat                                                   20


<210> 24561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24561
atcagagatg tagtagaggc                                                   20


<210> 24562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24562
gtagatcaga gatgtagtag                                                   20


<210> 24563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24563
tgtagatcag agatgtagta                                                   20


<210> 24564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24564
agtgtagatc agagatgtag                                                   20


<210> 24565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24565
aaaagtgtag atcagagatg                                                   20


<210> 24566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24566
tttttaaaaa gtgtagatca                                                   20


<210> 24567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24567
tatttttaaa aagtgtagat                                                   20


<210> 24568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24568
gacattattt ttaaaaagtg                                                   20


<210> 24569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24569
caaatgacat tatttttaaa                                                   20


<210> 24570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24570
tccagcctgg acgacagagg                                                   20


<210> 24571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24571
cactccagcc tggacgacag                                                   20


<210> 24572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24572
gcactccagc ctggacgaca                                                   20


<210> 24573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24573
ctgcactcca gcctggacga                                                   20


<210> 24574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24574
tgtgccactg cactccagcc                                                   20


<210> 24575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24575
aagattgtgc cactgcactc                                                   20


<210> 24576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24576
ggcagaggtt gcagtgagcc                                                   20


<210> 24577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24577
caggaggcag aggttgcagt                                                   20


<210> 24578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24578
aatccaggag gcagaggttg                                                   20


<210> 24579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24579
tacttgaatc caggaggcag                                                   20


<210> 24580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24580
ttacttgaat ccaggaggca                                                   20


<210> 24581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24581
aattacttga atccaggagg                                                   20


<210> 24582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24582
gagaattact tgaatccagg                                                   20


<210> 24583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24583
cgagaattac ttgaatccag                                                   20


<210> 24584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24584
cacgagaatt acttgaatcc                                                   20


<210> 24585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24585
gcacgagaat tacttgaatc                                                   20


<210> 24586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24586
tacttgtgag gctgaggcac                                                   20


<210> 24587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24587
cccagctact tgtgaggctg                                                   20


<210> 24588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24588
tcccagctac ttgtgaggct                                                   20


<210> 24589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24589
tataatccca gctacttgtg                                                   20


<210> 24590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24590
ctataatccc agctacttgt                                                   20


<210> 24591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24591
gtgatacatg cctataatcc                                                   20


<210> 24592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24592
aaaaaaaaat taattgatct                                                   20


<210> 24593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24593
caagaccagc ctggccaacg                                                   20


<210> 24594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24594
ccaggagttc aagaccagcc                                                   20


<210> 24595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24595
tgaggccagg agttcaagac                                                   20


<210> 24596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24596
tcacttgagg ccaggagttc                                                   20


<210> 24597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24597
gggcgatcac ttgaggccag                                                   20


<210> 24598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24598
gtgggcgatc acttgaggcc                                                   20


<210> 24599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24599
ggtgggcgat cacttgaggc                                                   20


<210> 24600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24600
ccgaggtggg cgatcacttg                                                   20


<210> 24601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24601
gccgaggtgg gcgatcactt                                                   20


<210> 24602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24602
gtactttggg aggccgaggt                                                   20


<210> 24603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24603
agtactttgg gaggccgagg                                                   20


<210> 24604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24604
tccagtactt tgggaggccg                                                   20


<210> 24605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24605
ttccagtact ttgggaggcc                                                   20


<210> 24606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24606
tataattcca gtactttggg                                                   20


<210> 24607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24607
ctataattcc agtactttgg                                                   20


<210> 24608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24608
acctataatt ccagtacttt                                                   20


<210> 24609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24609
cacctataat tccagtactt                                                   20


<210> 24610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24610
gtggctcaca cctataattc                                                   20


<210> 24611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24611
aggtcagagg ctgggtgaag                                                   20


<210> 24612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24612
ttaaggtcag aggctgggtg                                                   20


<210> 24613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24613
aaaagttaag gtcagaggct                                                   20


<210> 24614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24614
taaaagttaa ggtcagaggc                                                   20


<210> 24615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24615
ggattaaaag ttaaggtcag                                                   20


<210> 24616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24616
aggattaaaa gttaaggtca                                                   20


<210> 24617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24617
agaggattaa aagttaaggt                                                   20


<210> 24618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24618
gggaagagga ttaaaagtta                                                   20


<210> 24619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24619
tgggaagagg attaaaagtt                                                   20


<210> 24620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24620
aaagatggga agaggattaa                                                   20


<210> 24621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24621
gaataatgaa agatgggaag                                                   20


<210> 24622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24622
agaataatga aagatgggaa                                                   20


<210> 24623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24623
ggagaataat gaaagatggg                                                   20


<210> 24624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24624
gatggagaat aatgaaagat                                                   20


<210> 24625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24625
agatggagaa taatgaaaga                                                   20


<210> 24626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24626
aaatagatgg agaataatga                                                   20


<210> 24627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24627
ccaagaggcc aaaatagatg                                                   20


<210> 24628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24628
aaccaagagg ccaaaataga                                                   20


<210> 24629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24629
gaaaaaccaa gaggccaaaa                                                   20


<210> 24630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24630
aacatttggg aaaaaccaag                                                   20


<210> 24631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24631
taacatttgg gaaaaaccaa                                                   20


<210> 24632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24632
cataacattt gggaaaaacc                                                   20


<210> 24633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24633
tgaggatatg cataacattt                                                   20


<210> 24634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24634
gtgaggatat gcataacatt                                                   20


<210> 24635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24635
aaggcacatg ccccaaggtg                                                   20


<210> 24636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24636
gaaggcacat gccccaaggt                                                   20


<210> 24637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24637
taatgaaggc acatgcccca                                                   20


<210> 24638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24638
gtaatgaagg cacatgcccc                                                   20


<210> 24639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24639
tattttaggc agagtaatga                                                   20


<210> 24640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24640
gtattttagg cagagtaatg                                                   20


<210> 24641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24641
gagggaaagt attttaggca                                                   20


<210> 24642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24642
tggagggaaa gtattttagg                                                   20


<210> 24643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24643
atatggaggg aaagtatttt                                                   20


<210> 24644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24644
tatatggagg gaaagtattt                                                   20


<210> 24645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24645
cgtgcaaata tatggaggga                                                   20


<210> 24646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24646
gggccgtgca aatatatgga                                                   20


<210> 24647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24647
ggggccgtgc aaatatatgg                                                   20


<210> 24648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24648
gggggccgtg caaatatatg                                                   20


<210> 24649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24649
aagggggccg tgcaaatata                                                   20


<210> 24650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24650
gatgtaaaga aaattgaagg                                                   20


<210> 24651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24651
tgatgtaaag aaaattgaag                                                   20


<210> 24652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24652
gtgatgtaaa gaaaattgaa                                                   20


<210> 24653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24653
cgtgatgtaa agaaaattga                                                   20


<210> 24654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24654
ccgtgatgta aagaaaattg                                                   20


<210> 24655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24655
ggcgtttctt ccgtgatgta                                                   20


<210> 24656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24656
agaaagcctg cctataaagg                                                   20


<210> 24657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24657
cagagaaagc ctgcctataa                                                   20


<210> 24658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24658
tcagagaaag cctgcctata                                                   20


<210> 24659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24659
aatgaatgat tggtcagaga                                                   20


<210> 24660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24660
tatcaatgaa tgattggtca                                                   20


<210> 24661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24661
gctatcaatg aatgattggt                                                   20


<210> 24662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24662
atatgctatc aatgaatgat                                                   20


<210> 24663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24663
agtgaggggg aagaacttac                                                   20


<210> 24664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24664
gaataccaag agtgaggggg                                                   20


<210> 24665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24665
gaggaatacc aagagtgagg                                                   20


<210> 24666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24666
agaggaatac caagagtgag                                                   20


<210> 24667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24667
aagaggaata ccaagagtga                                                   20


<210> 24668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24668
aaagaggaat accaagagtg                                                   20


<210> 24669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24669
aaaagaggaa taccaagagt                                                   20


<210> 24670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24670
atggaaaaga ggaataccaa                                                   20


<210> 24671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24671
atatggaaaa gaggaatacc                                                   20


<210> 24672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24672
ggagaaggta tatggaaaag                                                   20


<210> 24673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24673
tggagaaggt atatggaaaa                                                   20


<210> 24674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24674
tatggagaag gtatatggaa                                                   20


<210> 24675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24675
agtgctatgg agaaggtata                                                   20


<210> 24676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24676
agtgaaaagt gctatggaga                                                   20


<210> 24677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24677
aagtgaaaag tgctatggag                                                   20


<210> 24678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24678
gataagtgaa aagtgctatg                                                   20


<210> 24679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24679
cagataagtg aaaagtgcta                                                   20


<210> 24680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24680
tagcaggtca gataagtgaa                                                   20


<210> 24681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24681
caagatgtag caggtcagat                                                   20


<210> 24682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24682
catatcaaga tgtagcaggt                                                   20


<210> 24683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24683
gaaacatatc aagatgtagc                                                   20


<210> 24684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24684
agaaacatat caagatgtag                                                   20


<210> 24685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24685
tgaagaaaca tatcaagatg                                                   20


<210> 24686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24686
ccttgctgaa gaaacatatc                                                   20


<210> 24687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24687
caaaacaata ccccttgctg                                                   20


<210> 24688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24688
ccaggcactg gagggagatg                                                   20


<210> 24689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24689
ttccaggcac tggagggaga                                                   20


<210> 24690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24690
ccagttccag gcactggagg                                                   20


<210> 24691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24691
gtccagttcc aggcactgga                                                   20


<210> 24692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24692
ggtccagttc caggcactgg                                                   20


<210> 24693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24693
aggtccagtt ccaggcactg                                                   20


<210> 24694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24694
ccaggtccag ttccaggcac                                                   20


<210> 24695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24695
tgtgtgccag gtccagttcc                                                   20


<210> 24696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24696
ctgtgtgcca ggtccagttc                                                   20


<210> 24697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24697
aaatacctgt gtgccaggtc                                                   20


<210> 24698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24698
ttattaaata cctgtgtgcc                                                   20


<210> 24699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24699
attattaaat acctgtgtgc                                                   20


<210> 24700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24700
cacataatca ttctttattc                                                   20


<210> 24701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24701
agtgaagcag ccaatttgct                                                   20


<210> 24702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24702
gcctaataaa ttcagtgaag                                                   20


<210> 24703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24703
gtagcctaat aaattcagtg                                                   20


<210> 24704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24704
gatctgtagc ctaataaatt                                                   20


<210> 24705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24705
tcatacagtc tctggatctg                                                   20


<210> 24706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24706
cagagacttc atacagtctc                                                   20


<210> 24707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24707
gctccagcag agacttcata                                                   20


<210> 24708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24708
cccttttatg tgctccagca                                                   20


<210> 24709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24709
atccctttta tgtgctccag                                                   20


<210> 24710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24710
cacatccctt ttatgtgctc                                                   20


<210> 24711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24711
ctgagggagc atatatctct                                                   20


<210> 24712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24712
accattgaaa tttactgagg                                                   20


<210> 24713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24713
ggaccattga aatttactga                                                   20


<210> 24714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24714
tggaccattg aaatttactg                                                   20


<210> 24715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24715
ttggaccatt gaaatttact                                                   20


<210> 24716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24716
ttttccaatg aacctgggct                                                   20


<210> 24717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24717
acacattttc caatgaacct                                                   20


<210> 24718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24718
aacacatttt ccaatgaacc                                                   20


<210> 24719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24719
ccagtataga agaaatatta                                                   20


<210> 24720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24720
ccaaactgag gccagtatag                                                   20


<210> 24721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24721
cttccaaact gaggccagta                                                   20


<210> 24722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24722
cattgcttcc aaactgaggc                                                   20


<210> 24723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24723
tattcattgc ttccaaactg                                                   20


<210> 24724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24724
ttattcattg cttccaaact                                                   20


<210> 24725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24725
aatacttttg tgaatactct                                                   20


<210> 24726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24726
ttataataag atataataca                                                   20


<210> 24727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24727
actgtaggtg ctgttataat                                                   20


<210> 24728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24728
actatgctat ttcagactgt                                                   20


<210> 24729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24729
tactatgcta tttcagactg                                                   20


<210> 24730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24730
gtattaatac tatgctattt                                                   20


<210> 24731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24731
aaaacttaaa ctcttacaga                                                   20


<210> 24732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24732
tcaaaaaact taaactctta                                                   20


<210> 24733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24733
tgggcttatc aatcaactta                                                   20


<210> 24734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24734
aggataacta gaaagaagtt                                                   20


<210> 24735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24735
taggataact agaaagaagt                                                   20


<210> 24736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24736
attctaggat aactagaaag                                                   20


<210> 24737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24737
aaaattctag gataactaga                                                   20


<210> 24738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24738
acttaaaatt ctaggataac                                                   20


<210> 24739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24739
tgatcatgac ttaaaattct                                                   20


<210> 24740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24740
atgatcatga cttaaaattc                                                   20


<210> 24741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24741
aaatttgtat tgatgctacc                                                   20


<210> 24742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24742
agaaatttat tagcagtata                                                   20


<210> 24743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24743
ctcctcaaga aatttattag                                                   20


<210> 24744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24744
ctgctcctca agaaatttat                                                   20


<210> 24745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24745
acatgtatgg cctgctcctc                                                   20


<210> 24746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24746
aagaatttca tcaacatgta                                                   20


<210> 24747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24747
tgtccatgtt acagagattt                                                   20


<210> 24748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24748
ttaaaagtgt ccatgttaca                                                   20


<210> 24749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24749
ctttaaaagt gtccatgtta                                                   20


<210> 24750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24750
aaatgcacag tttcctttaa                                                   20


<210> 24751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24751
tagtgctata agcaaatgca                                                   20


<210> 24752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24752
cttgctgaaa ttagtgctat                                                   20


<210> 24753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24753
aattttgtgc ttgctgaaat                                                   20


<210> 24754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24754
aagcaaaggt gtacgacatc                                                   20


<210> 24755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24755
tcattttatg taagaagcaa                                                   20


<210> 24756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24756
atcattttat gtaagaagca                                                   20


<210> 24757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24757
caaatatcat tttatgtaag                                                   20


<210> 24758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24758
caccaaatat cattttatgt                                                   20


<210> 24759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24759
agcaaactac aaagagtgca                                                   20


<210> 24760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24760
agacatcagc aaactacaaa                                                   20


<210> 24761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24761
aaagacatca gcaaactaca                                                   20


<210> 24762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24762
tgattggaaa ataaagacat                                                   20


<210> 24763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24763
agcaaaatga ttggaaaata                                                   20


<210> 24764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24764
catgggttaa gcaaaatgat                                                   20


<210> 24765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24765
tcttataaca ttcatgggtt                                                   20


<210> 24766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24766
tggtttctta taacattcat                                                   20


<210> 24767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24767
ctggtttctt ataacattca                                                   20


<210> 24768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24768
gtgtccaaga ttttctcaac                                                   20


<210> 24769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24769
tcgacttgct ttcagtgtcc                                                   20


<210> 24770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24770
aaaaatcatc gacttgcttt                                                   20


<210> 24771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24771
catgggctta ccctcagcat                                                   20


<210> 24772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24772
tctagtcatg ggcttaccct                                                   20


<210> 24773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24773
ctaatgactt atctagtcat                                                   20


<210> 24774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24774
gctaatgact tatctagtca                                                   20


<210> 24775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24775
acagatgcta atgacttatc                                                   20


<210> 24776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24776
atacagaagt tatgatagca                                                   20


<210> 24777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24777
atcttataca gaagttatga                                                   20


<210> 24778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24778
ctgttaacaa tcttatacag                                                   20


<210> 24779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24779
attctgttaa caatcttata                                                   20


<210> 24780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24780
tctacttttc ttattcttca                                                   20


<210> 24781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24781
ttctactttt cttattcttc                                                   20


<210> 24782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24782
tgattataaa cttactagca                                                   20


<210> 24783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24783
gataatgatt ataaacttac                                                   20


<210> 24784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24784
cgatgctaag aggatcaaat                                                   20


<210> 24785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24785
cacatcacag cgatgctaag                                                   20


<210> 24786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24786
ccacatcaca gcgatgctaa                                                   20


<210> 24787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24787
atccacatca cagcgatgct                                                   20


<210> 24788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24788
ggatatcagc atccacatca                                                   20


<210> 24789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24789
catctgtaaa atggggatat                                                   20


<210> 24790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24790
gatatctcat ctgtaaaatg                                                   20


<210> 24791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24791
agatatctca tctgtaaaat                                                   20


<210> 24792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24792
cagatatctc atctgtaaaa                                                   20


<210> 24793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24793
caatttaaaa tcttgttctt                                                   20


<210> 24794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24794
ttgccgactt atctgcctgt                                                   20


<210> 24795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24795
aatacaaagt tcaaactttg                                                   20


<210> 24796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24796
gtaatacaaa gttcaaactt                                                   20


<210> 24797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24797
caatgtaata cagtaataca                                                   20


<210> 24798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24798
agtagggctg caatgtaata                                                   20


<210> 24799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24799
aaaaatacaa gcccagagta                                                   20


<210> 24800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24800
taaaaataca agcccagagt                                                   20


<210> 24801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24801
gtaaaaatac aagcccagag                                                   20


<210> 24802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24802
taggtaaaaa tacaagccca                                                   20


<210> 24803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24803
tctaggtaaa aatacaagcc                                                   20


<210> 24804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24804
tatcatctag gtaaaaatac                                                   20


<210> 24805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24805
gaacaagtat tgtatcatct                                                   20


<210> 24806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24806
tgaacaagta ttgtatcatc                                                   20


<210> 24807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24807
taatgcagta ttgtctgaac                                                   20


<210> 24808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24808
ggaatttgtc agggataatg                                                   20


<210> 24809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24809
actacttctg gaatttgtca                                                   20


<210> 24810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24810
tactacttct ggaatttgtc                                                   20


<210> 24811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24811
ttactacttc tggaatttgt                                                   20


<210> 24812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24812
gctgaatttc ttactacttc                                                   20


<210> 24813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24813
cttagtctct tgttttgtaa                                                   20


<210> 24814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24814
aagttcttta catttggcct                                                   20


<210> 24815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24815
catgtaaagt tctttacatt                                                   20


<210> 24816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24816
agtccttaac ttgacatgta                                                   20


<210> 24817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24817
ggcctctagg gtaaagtctg                                                   20


<210> 24818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24818
aatccttggc ctctagggta                                                   20


<210> 24819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24819
gtgagaatcc ttggcctcta                                                   20


<210> 24820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24820
tgtgagaatc cttggcctct                                                   20


<210> 24821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24821
atgtgagaat ccttggcctc                                                   20


<210> 24822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24822
cactaaaatg tgagaatcct                                                   20


<210> 24823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24823
ttgcatgcac actaaaatgt                                                   20


<210> 24824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24824
atagggccca agcccttaag                                                   20


<210> 24825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24825
gatagggccc aagcccttaa                                                   20


<210> 24826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24826
gagatagggc ccaagccctt                                                   20


<210> 24827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24827
gaactctgga gatagggccc                                                   20


<210> 24828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24828
catcaggaac tctggagata                                                   20


<210> 24829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24829
tcatcaggaa ctctggagat                                                   20


<210> 24830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24830
ttcatcagga actctggaga                                                   20


<210> 24831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24831
caagttcatc aggaactctg                                                   20


<210> 24832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24832
cacaagttca tcaggaactc                                                   20


<210> 24833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24833
ttgctagtca caagttcatc                                                   20


<210> 24834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24834
cttgctagtc acaagttcat                                                   20


<210> 24835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24835
aagttttcct tgctagtcac                                                   20


<210> 24836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24836
acccttaaag ttttccttgc                                                   20


<210> 24837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24837
aagactttga gagaccctta                                                   20


<210> 24838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24838
cctcaagcta aagactttga                                                   20


<210> 24839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24839
accctcaagc taaagacttt                                                   20


<210> 24840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24840
tctaccttac cctcaagcta                                                   20


<210> 24841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24841
tcatgatcta ccttaccctc                                                   20


<210> 24842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24842
cagcttcctc cagtctttat                                                   20


<210> 24843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24843
gtatggttta cagcttcctc                                                   20


<210> 24844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24844
caaaacttta gtatggttta                                                   20


<210> 24845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24845
acaaaaacaa aactttagta                                                   20


<210> 24846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24846
caaaaacaaa aacaaaactt                                                   20


<210> 24847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24847
taagtttttt tttttttgaa                                                   20


<210> 24848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24848
taaaacattc caagtttaat                                                   20


<210> 24849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24849
tgttgtttgt aaaacattcc                                                   20


<210> 24850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24850
atctgcttac aattccccat                                                   20


<210> 24851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24851
ctaacctcac tcttgagtcc                                                   20


<210> 24852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24852
ttacctctaa cctcactctt                                                   20


<210> 24853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24853
atgcatgcct gtggcttgaa                                                   20


<210> 24854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24854
aggtgtttca tgcatgcctg                                                   20


<210> 24855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24855
tttcttattc tgaagctctg                                                   20


<210> 24856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24856
ttttcttatt ctgaagctct                                                   20


<210> 24857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24857
agttatcttt tcttattctg                                                   20


<210> 24858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24858
ctccccacat gttcaatctt                                                   20


<210> 24859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24859
cctctctcta tttctttaat                                                   20


<210> 24860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24860
tttatttgtc ttagagttct                                                   20


<210> 24861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24861
ttggtctttt atttgtctta                                                   20


<210> 24862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24862
ctttggtctt ttatttgtct                                                   20


<210> 24863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24863
cagaggccat agtctacctt                                                   20


<210> 24864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24864
ttccttagtt tcagaggcca                                                   20


<210> 24865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24865
cttcctttcc ttagtttcag                                                   20


<210> 24866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24866
tcttcctttc cttagtttca                                                   20


<210> 24867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24867
attcttcctt tccttagttt                                                   20


<210> 24868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24868
ctcaaaattc ttcctttcct                                                   20


<210> 24869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24869
ctgtttgata ctgttgacta                                                   20


<210> 24870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24870
ggaatctact cactaactct                                                   20


<210> 24871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24871
ctggtccttt taatcaaaaa                                                   20


<210> 24872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24872
taatgaaaga gtctgtactc                                                   20


<210> 24873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24873
cagaatacaa gttaatgaaa                                                   20


<210> 24874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24874
accagaatac aagttaatga                                                   20


<210> 24875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24875
caatggaacc accagaatac                                                   20


<210> 24876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24876
tcccagatca atggaaccac                                                   20


<210> 24877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24877
aattcgtatt cccagatcaa                                                   20


<210> 24878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24878
agagccttaa ttcgtattcc                                                   20


<210> 24879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24879
tgctactact tcttatttta                                                   20


<210> 24880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24880
catgctacta cttcttattt                                                   20


<210> 24881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24881
atcactgtat gttagactgt                                                   20


<210> 24882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24882
aatttcctat cactgtatgt                                                   20


<210> 24883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24883
catctatggc acttgactaa                                                   20


<210> 24884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24884
agcttgagtt tccacatcta                                                   20


<210> 24885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24885
cactagagct ctctaagctt                                                   20


<210> 24886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24886
gcaagtcact agagctctct                                                   20


<210> 24887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24887
tgattaaggg caagtcacta                                                   20


<210> 24888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24888
gatgattaag ggcaagtcac                                                   20


<210> 24889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24889
gctgtatgat gattaagggc                                                   20


<210> 24890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24890
tatagctgta tgatgattaa                                                   20


<210> 24891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24891
ctatagctgt atgatgatta                                                   20


<210> 24892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24892
gctatagctg tatgatgatt                                                   20


<210> 24893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24893
attccatgct gattcagcta                                                   20


<210> 24894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24894
gactccattc catgctgatt                                                   20


<210> 24895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24895
agaggttgtc ggtaagtcag                                                   20


<210> 24896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24896
accagaggtt gtcggtaagt                                                   20


<210> 24897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24897
acttaccaga ggttgtcggt                                                   20


<210> 24898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 24898
taatacttac cagaggttgt                                                   20


<210> 24899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24899
taacgcctaa tacttaccag                                                   20


<210> 24900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24900
ttaacgccta atacttacca                                                   20


<210> 24901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24901
tcttaacgcc taatacttac                                                   20


<210> 24902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24902
attccttaat tagtgttctg                                                   20


<210> 24903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24903
cattccttaa ttagtgttct                                                   20


<210> 24904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24904
gcattcctta attagtgttc                                                   20


<210> 24905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24905
cttggttagc attccttaat                                                   20


<210> 24906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24906
acaaaaattg agaccttggt                                                   20


<210> 24907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24907
taagacaaaa attgagacct                                                   20


<210> 24908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24908
cagatggtaa gacaaaaatt                                                   20


<210> 24909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24909
aggcctgttt cacagatggt                                                   20


<210> 24910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24910
ccagaggcct gtttcacaga                                                   20


<210> 24911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24911
tgagccagag gcctgtttca                                                   20


<210> 24912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24912
tatgaattcc gatgagccag                                                   20


<210> 24913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24913
ctatgaattc cgatgagcca                                                   20


<210> 24914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24914
acctatgaat tccgatgagc                                                   20


<210> 24915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24915
ctgaacctat gaattccgat                                                   20


<210> 24916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24916
tggagaagga gaagaagcag                                                   20


<210> 24917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24917
ctggagaagg agaagaagca                                                   20


<210> 24918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24918
gcctggagaa ggagaagaag                                                   20


<210> 24919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24919
tttgcctgga gaaggagaag                                                   20


<210> 24920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24920
ccctttgcct ggagaaggag                                                   20


<210> 24921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24921
taaccctttg cctggagaag                                                   20


<210> 24922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24922
gataaccctt tgcctggaga                                                   20


<210> 24923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24923
tgataaccct ttgcctggag                                                   20


<210> 24924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24924
agttgataac cctttgcctg                                                   20


<210> 24925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24925
acagttgata accctttgcc                                                   20


<210> 24926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24926
aagctcctca gagtgcagca                                                   20


<210> 24927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24927
cggtcaagct cctcagagtg                                                   20


<210> 24928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24928
taaaccggtc aagctcctca                                                   20


<210> 24929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24929
attaaaccgg tcaagctcct                                                   20


<210> 24930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24930
ttctagagat taaaccggtc                                                   20


<210> 24931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 24931
ttcctttcta gagattaaac                                                   20


<210> 24932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24932
gggtggtgaa ttcctttcta                                                   20


<210> 24933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24933
tggggtggtg aattcctttc                                                   20


<210> 24934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24934
aaatgaacta cctggtgggg                                                   20


<210> 24935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24935
tctaaatgaa ctacctggtg                                                   20


<210> 24936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24936
ctctaaatga actacctggt                                                   20


<210> 24937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24937
actctaaatg aactacctgg                                                   20


<210> 24938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24938
tgaactctaa atgaactacc                                                   20


<210> 24939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24939
atgagtctga ttattaaata                                                   20


<210> 24940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24940
catgagtctg attattaaat                                                   20


<210> 24941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24941
tttttcataa tactttgcat                                                   20


<210> 24942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24942
atgtgtttat acatttttta                                                   20


<210> 24943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24943
atcaagtata gatacattta                                                   20


<210> 24944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24944
gatcaagtat agatacattt                                                   20


<210> 24945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24945
gtagatagaa agatcaagta                                                   20


<210> 24946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24946
atggtgtaga tagaaagatc                                                   20


<210> 24947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24947
tacaggatgg tgtagataga                                                   20


<210> 24948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24948
attttacagg atggtgtaga                                                   20


<210> 24949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24949
tattatttta caggatggtg                                                   20


<210> 24950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24950
aagtttatta ttttacagga                                                   20


<210> 24951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24951
aataaagttt attattttac                                                   20


<210> 24952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24952
taataaagtt tattatttta                                                   20


<210> 24953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24953
ttagtataat aaacataata                                                   20


<210> 24954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24954
aattttggcc acgtacttgt                                                   20


<210> 24955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24955
tatattacct tatctaattt                                                   20


<210> 24956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24956
tcaatacttt ccaaaagtga                                                   20


<210> 24957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24957
atgtggtcaa tactttccaa                                                   20


<210> 24958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24958
aaaatttaaa aaataagatg                                                   20


<210> 24959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24959
atattaaaaa tttaaaaaat                                                   20


<210> 24960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24960
tgtcctcaaa taatgattgt                                                   20


<210> 24961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24961
ttatattgca aatagggtat                                                   20


<210> 24962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24962
attatattgc aaatagggta                                                   20


<210> 24963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24963
cttgtattat attgcaaata                                                   20


<210> 24964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24964
acttgtatta tattgcaaat                                                   20


<210> 24965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24965
cacttgtatt atattgcaaa                                                   20


<210> 24966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24966
agctttcaat gatcaggcat                                                   20


<210> 24967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 24967
gatctgagct ttcaatgatc                                                   20


<210> 24968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24968
tgatctgagc tttcaatgat                                                   20


<210> 24969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24969
ttttgccaac tatttgatct                                                   20


<210> 24970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24970
aaaaaatttt aactatcaat                                                   20


<210> 24971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24971
gagataataa aaaatacatt                                                   20


<210> 24972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24972
ctacatatat ttaaattcaa                                                   20


<210> 24973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24973
tgctacatat atttaaattc                                                   20


<210> 24974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24974
tgattttgtg gtcttgatca                                                   20


<210> 24975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24975
caaaaccgta tttgattttg                                                   20


<210> 24976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24976
ggtggtgttg gtatggtcat                                                   20


<210> 24977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24977
caaaatgggt ggtgttggta                                                   20


<210> 24978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24978
atatacaaaa tgggtggtgt                                                   20


<210> 24979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24979
aatgttatat acaaaatggg                                                   20


<210> 24980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24980
taaaatgtta tatacaaaat                                                   20


<210> 24981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24981
ctaaaatgtt atatacaaaa                                                   20


<210> 24982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24982
gcatgtggtg cttactttag                                                   20


<210> 24983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 24983
tttgcatgtg gtgcttactt                                                   20


<210> 24984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24984
tttgtttcag agtttgcatg                                                   20


<210> 24985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24985
tttcttcgat ctttgtttca                                                   20


<210> 24986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24986
attttcttcg atctttgttt                                                   20


<210> 24987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24987
gaattcatta ttccatgtgt                                                   20


<210> 24988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24988
ttactcataa agctctgggt                                                   20


<210> 24989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24989
atggttactc ataaagctct                                                   20


<210> 24990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24990
catggttact cataaagctc                                                   20


<210> 24991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24991
aaacatcatg gttactcata                                                   20


<210> 24992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24992
gtgtgtatgt gtaaacatca                                                   20


<210> 24993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 24993
tgctgtatgt attttttgta                                                   20


<210> 24994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24994
aatttgacag agttttgcta                                                   20


<210> 24995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24995
aatatttggg aaatttgaca                                                   20


<210> 24996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 24996
acaatatttg ggaaatttga                                                   20


<210> 24997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 24997
tcctttataa aacaatattt                                                   20


<210> 24998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 24998
ctcctttata aaacaatatt                                                   20


<210> 24999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 24999
tcacatgtca tttagcaaat                                                   20


<210> 25000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25000
ttcaatattc acatgtcatt                                                   20


<210> 25001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25001
aattgtgttg tagtaactag                                                   20


<210> 25002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25002
gagaattgtg ttgtagtaac                                                   20


<210> 25003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25003
ttaataagag aattgtgttg                                                   20


<210> 25004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25004
ataaagttgt aacttaataa                                                   20


<210> 25005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25005
agataaagtt gtaacttaat                                                   20


<210> 25006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25006
gaactactct aaaaaagata                                                   20


<210> 25007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25007
ttgcttgaac tactctaaaa                                                   20


<210> 25008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25008
aataagtatt ttattatttt                                                   20


<210> 25009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25009
agaatcaatt tatctgaaat                                                   20


<210> 25010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25010
ttaatacaaa ttcatagatt                                                   20


<210> 25011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25011
atcatattaa tacaaattca                                                   20


<210> 25012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25012
aaaagtcaaa cctttagatt                                                   20


<210> 25013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25013
taaaagtcaa acctttagat                                                   20


<210> 25014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25014
atctctaaaa gtcaaacctt                                                   20


<210> 25015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25015
gcttccaagt caatctctaa                                                   20


<210> 25016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25016
caagaatact tctagcttcc                                                   20


<210> 25017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25017
gtacccatca agaatacttc                                                   20


<210> 25018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25018
aatttaatgt ggtacccatc                                                   20


<210> 25019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25019
atagcattga gaatttaatg                                                   20


<210> 25020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25020
taggtgataa taatagcatt                                                   20


<210> 25021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25021
tgtatactag gtgataataa                                                   20


<210> 25022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25022
tttttatgat gttgtatact                                                   20


<210> 25023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25023
atttttatga tgttgtatac                                                   20


<210> 25024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25024
tatttactcc agttataaga                                                   20


<210> 25025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25025
taattattta ctccagttat                                                   20


<210> 25026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25026
ttgttcataa ttatttactc                                                   20


<210> 25027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25027
attggaggag ttctcttaat                                                   20


<210> 25028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25028
gattggagga gttctcttaa                                                   20


<210> 25029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25029
taggccaaca tagattggag                                                   20


<210> 25030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25030
tctaggccaa catagattgg                                                   20


<210> 25031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25031
ctctaggcca acatagattg                                                   20


<210> 25032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25032
gcctctaggc caacatagat                                                   20


<210> 25033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25033
ataatgcctc taggccaaca                                                   20


<210> 25034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25034
ctggtgggaa taatgcctct                                                   20


<210> 25035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25035
cctggtggga ataatgcctc                                                   20


<210> 25036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25036
atcaaactcc tggacctggt                                                   20


<210> 25037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25037
tatcaaactc ctggacctgg                                                   20


<210> 25038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25038
tgttatcaaa ctcctggacc                                                   20


<210> 25039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25039
tgaaactgtt atcaaactcc                                                   20


<210> 25040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25040
agtttaaata acatgttttt                                                   20


<210> 25041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25041
ctaatttaga tgaattcaat                                                   20


<210> 25042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25042
tattttaaat taaactaatt                                                   20


<210> 25043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25043
ctatagtttt atagaatatt                                                   20


<210> 25044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25044
aagcctattc tatagtttta                                                   20


<210> 25045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25045
atactttaaa gcctattcta                                                   20


<210> 25046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25046
attctatagt ttatacttta                                                   20


<210> 25047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25047
atattttaaa actcattcta                                                   20


<210> 25048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25048
gtttatccaa catcgtttcc                                                   20


<210> 25049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25049
aaatacatat tagtaattat                                                   20


<210> 25050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25050
aattggcaca aaatacatat                                                   20


<210> 25051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25051
actttggatt ttgtggcaat                                                   20


<210> 25052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25052
atatggtact ttggattttg                                                   20


<210> 25053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25053
gtcttctaaa tatggtactt                                                   20


<210> 25054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25054
aaactgtagt cttctaaata                                                   20


<210> 25055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25055
aattgaagcc attaaaactg                                                   20


<210> 25056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25056
agccgagagg tcaggaattg                                                   20


<210> 25057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25057
tcacgtgcag ccgagaggtc                                                   20


<210> 25058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25058
ttcacgtgca gccgagaggt                                                   20


<210> 25059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25059
atagttcacg tgcagccgag                                                   20


<210> 25060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25060
gatagttcac gtgcagccga                                                   20


<210> 25061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25061
gtgatagttc acgtgcagcc                                                   20


<210> 25062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25062
ctctggtgat agttcacgtg                                                   20


<210> 25063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25063
gtctttcact tctctggtga                                                   20


<210> 25064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25064
ggccttgtct ttcacttctc                                                   20


<210> 25065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25065
cttaacttca cagaataata                                                   20


<210> 25066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25066
tcttaacttc acagaataat                                                   20


<210> 25067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25067
gtcttaactt cacagaataa                                                   20


<210> 25068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25068
agggcctggt cttaacttca                                                   20


<210> 25069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25069
tttttcagaa atgaagggcc                                                   20


<210> 25070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25070
attctttttt cagaaatgaa                                                   20


<210> 25071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25071
aattcttttt tcagaaatga                                                   20


<210> 25072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25072
taattctttt ttcagaaatg                                                   20


<210> 25073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25073
caggccaata attctttttt                                                   20


<210> 25074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25074
actgctttac ctcaaaaccc                                                   20


<210> 25075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25075
cactgcttta cctcaaaacc                                                   20


<210> 25076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25076
gtgctttgta ttctttctat                                                   20


<210> 25077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25077
tattgtgtct aatagcaggg                                                   20


<210> 25078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25078
atattgtgtc taatagcagg                                                   20


<210> 25079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25079
aatattgtgt ctaatagcag                                                   20


<210> 25080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25080
taatattgtg tctaatagca                                                   20


<210> 25081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25081
ttaatattgt gtctaatagc                                                   20


<210> 25082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25082
gttaatattg tgtctaatag                                                   20


<210> 25083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25083
attgttaata ttgtgtctaa                                                   20


<210> 25084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25084
taaaagttgt taccagctca                                                   20


<210> 25085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25085
tttaaaagtt gttaccagct                                                   20


<210> 25086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25086
ttttatttaa aagttgttac                                                   20


<210> 25087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25087
ataagaatca ttttatttaa                                                   20


<210> 25088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25088
aaagtcagaa ttctgcaaat                                                   20


<210> 25089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25089
ttcatgaatt tagctaaagt                                                   20


<210> 25090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25090
tgctttcatg aatttagcta                                                   20


<210> 25091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25091
tgaagatgct ttcatgaatt                                                   20


<210> 25092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25092
aaaccaatta ttgatgtttg                                                   20


<210> 25093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25093
ttaatgctct cttaaacagt                                                   20


<210> 25094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25094
tttgttaatg ctctcttaaa                                                   20


<210> 25095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25095
tacttgctca taatctaatt                                                   20


<210> 25096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25096
tgaaaaaaag tttcaacaac                                                   20


<210> 25097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25097
taaaacctgc atatgaaaaa                                                   20


<210> 25098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25098
atgatgtaaa attctgtgcc                                                   20


<210> 25099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25099
aaatacaaat taattaataa                                                   20


<210> 25100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25100
ttgaatgtct aagaatctat                                                   20


<210> 25101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25101
caagaaaaca ttgaatgtct                                                   20


<210> 25102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25102
tgaatactta atgcattccc                                                   20


<210> 25103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25103
ttttatatac agtatggaaa                                                   20


<210> 25104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25104
atttaatttt atatacagta                                                   20


<210> 25105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25105
taaacattta attttatata                                                   20


<210> 25106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25106
tagaactgtc tatattgcta                                                   20


<210> 25107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25107
atttcaaagg ctgaattgac                                                   20


<210> 25108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25108
gtagcaagta tagatttcaa                                                   20


<210> 25109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25109
tgtagcaagt atagatttca                                                   20


<210> 25110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25110
agcttatact gtagcaagta                                                   20


<210> 25111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25111
aaagaagctt atactgtagc                                                   20


<210> 25112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25112
tgctaaagaa gcttatactg                                                   20


<210> 25113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25113
ctcttagaaa tctgctaaag                                                   20


<210> 25114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25114
attctcttag aaatctgcta                                                   20


<210> 25115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25115
tctatataaa ggtattctct                                                   20


<210> 25116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25116
atatcagcct ttctatataa                                                   20


<210> 25117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25117
tatatcagcc tttctatata                                                   20


<210> 25118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25118
aaaaacttta ttatatatat                                                   20


<210> 25119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25119
aattcaatat atttcaccgc                                                   20


<210> 25120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25120
gaattcaata tatttcaccg                                                   20


<210> 25121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25121
aatatggtga tgcctactgt                                                   20


<210> 25122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25122
atattcaaag tacttaaata                                                   20


<210> 25123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25123
tagtaaaaaa catatattca                                                   20


<210> 25124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25124
ttgatatgat cttccttgta                                                   20


<210> 25125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25125
ttaaagaaat gaagataata                                                   20


<210> 25126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25126
tgattgagtt taaagaaatg                                                   20


<210> 25127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25127
acaacagatg attgagttta                                                   20


<210> 25128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25128
aaactaaaca acagatgatt                                                   20


<210> 25129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25129
ttacatggaa aactaaacaa                                                   20


<210> 25130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25130
ctttcatttc caaaattaca                                                   20


<210> 25131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25131
tttatttcac ttctctaata                                                   20


<210> 25132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25132
aagaaatttc tttcatacta                                                   20


<210> 25133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25133
ggtcctattt ataatagcaa                                                   20


<210> 25134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25134
acagaaggtc ctatttataa                                                   20


<210> 25135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25135
atccatgtga aaattacaga                                                   20


<210> 25136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25136
aatccatgtg aaaattacag                                                   20


<210> 25137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25137
tcaaatccat gtgaaaatta                                                   20


<210> 25138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25138
aattgatact tcccttttat                                                   20


<210> 25139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25139
atatttactt tatttataac                                                   20


<210> 25140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25140
ttctgattcc taatactagt                                                   20


<210> 25141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25141
acacttctga ttcctaatac                                                   20


<210> 25142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25142
aaaggcagga atgctaatta                                                   20


<210> 25143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25143
atattattca ataaaaaggc                                                   20


<210> 25144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25144
catattattc aataaaaagg                                                   20


<210> 25145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25145
tatcatatta ttcaataaaa                                                   20


<210> 25146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25146
atatcatatt attcaataaa                                                   20


<210> 25147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25147
taaaacactt ttagaaggca                                                   20


<210> 25148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25148
atttttaaaa cacttttaga                                                   20


<210> 25149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25149
tatttttaaa acacttttag                                                   20


<210> 25150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25150
tcatattttt aaaacacttt                                                   20


<210> 25151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25151
attatacatt taaaatgttt                                                   20


<210> 25152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25152
tgaatcaagg agatagtgga                                                   20


<210> 25153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25153
ttgaatcaag gagatagtgg                                                   20


<210> 25154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25154
gttgaatcaa ggagatagtg                                                   20


<210> 25155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25155
gggttgaatc aaggagatag                                                   20


<210> 25156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25156
agggggttga atcaaggaga                                                   20


<210> 25157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25157
ctcaaggggg ttgaatcaag                                                   20


<210> 25158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25158
acctcaaggg ggttgaatca                                                   20


<210> 25159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25159
tacctcaagg gggttgaatc                                                   20


<210> 25160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25160
ctctctcgat tacctcaagg                                                   20


<210> 25161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25161
tctctctcga ttacctcaag                                                   20


<210> 25162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25162
ctctctctcg attacctcaa                                                   20


<210> 25163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25163
tctctctctc gattacctca                                                   20


<210> 25164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25164
ttctctctct cgattacctc                                                   20


<210> 25165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25165
tgcacactga aaaatatgga                                                   20


<210> 25166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25166
tggatgcaca ctgaaaaata                                                   20


<210> 25167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25167
ttcacagcta tagtgttgta                                                   20


<210> 25168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25168
taaggattgt ttcacagcta                                                   20


<210> 25169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25169
tcaagataag gattgtttca                                                   20


<210> 25170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25170
ataagtttac aatcaagata                                                   20


<210> 25171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25171
cataagttta caatcaagat                                                   20


<210> 25172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25172
agctacataa gtttacaatc                                                   20


<210> 25173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25173
agcatcttaa atagctacat                                                   20


<210> 25174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25174
ttgaaaagga gcatcttaaa                                                   20


<210> 25175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25175
tattttcagt aattgaaaag                                                   20


<210> 25176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25176
catattttca gtaattgaaa                                                   20


<210> 25177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25177
acatattttc agtaattgaa                                                   20


<210> 25178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25178
ttttaatttg gacatatttt                                                   20


<210> 25179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25179
gaataataaa gcttttaatt                                                   20


<210> 25180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25180
gaaaaccatg aagaataata                                                   20


<210> 25181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25181
caatcaaagg gaaaaccatg                                                   20


<210> 25182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25182
acagcttcaa ggcaatcaaa                                                   20


<210> 25183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25183
cacagcttca aggcaatcaa                                                   20


<210> 25184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25184
acacagcttc aaggcaatca                                                   20


<210> 25185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25185
tagtagaaaa cacagcttca                                                   20


<210> 25186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25186
atagtagaaa acacagcttc                                                   20


<210> 25187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25187
aagcagtata gtagaaaaca                                                   20


<210> 25188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25188
tttctactca agcagtatag                                                   20


<210> 25189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25189
caatttctac tcaagcagta                                                   20


<210> 25190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25190
taacacaatt tctactcaag                                                   20


<210> 25191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25191
atttaacaca atttctactc                                                   20


<210> 25192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25192
aatttgtaag tgaacaactt                                                   20


<210> 25193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25193
aaatttgtaa gtgaacaact                                                   20


<210> 25194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25194
aatgccagtg ataaatttgt                                                   20


<210> 25195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25195
atgtttatct taggaaatgc                                                   20


<210> 25196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25196
acatcgttaa tgtttatctt                                                   20


<210> 25197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25197
tacatcgtta atgtttatct                                                   20


<210> 25198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25198
catccatgat agcatgaaat                                                   20


<210> 25199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25199
tcatccatga tagcatgaaa                                                   20


<210> 25200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25200
gcattaacca tcatccatga                                                   20


<210> 25201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25201
ctcttggaac aataaataac                                                   20


<210> 25202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25202
cactcctacc tcacacctct                                                   20


<210> 25203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25203
gcgttagatt atcaagtcat                                                   20


<210> 25204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25204
cttttgagcg ttagattatc                                                   20


<210> 25205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25205
tagtttcttc ttttgagcgt                                                   20


<210> 25206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25206
gtttgatagt ttcttctttt                                                   20


<210> 25207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25207
tacagtgctg ctgtgtttga                                                   20


<210> 25208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25208
gttgagttct gtgttttgta                                                   20


<210> 25209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25209
ctttgagtaa ggtttttgtt                                                   20


<210> 25210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25210
tcaatcattc tctttgagta                                                   20


<210> 25211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25211
atcaatcatt ctctttgagt                                                   20


<210> 25212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25212
cagcatcaat cattctcttt                                                   20


<210> 25213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25213
taacattttt cagttctttt                                                   20


<210> 25214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25214
acttgaaatg taacattttt                                                   20


<210> 25215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25215
tgtgtgaagc aaacagttta                                                   20


<210> 25216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25216
tttttgttgt gtgaagcaaa                                                   20


<210> 25217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25217
atcttttttt ttgttgtgtg                                                   20


<210> 25218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25218
attctaggct ctgctcctta                                                   20


<210> 25219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25219
tcaggtgaaa taaccattct                                                   20


<210> 25220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25220
ctcaggtgaa ataaccattc                                                   20


<210> 25221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25221
ttgtgagtat tttaaggctc                                                   20


<210> 25222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25222
tttgtgagta ttttaaggct                                                   20


<210> 25223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25223
tgtcttttgt gagtatttta                                                   20


<210> 25224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25224
ctgtcttttg tgagtatttt                                                   20


<210> 25225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25225
actttcttac tgtcttttgt                                                   20


<210> 25226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25226
tattaacaga taatggagct                                                   20


<210> 25227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25227
ttgcttatta acagataatg                                                   20


<210> 25228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25228
tcttgcttat taacagataa                                                   20


<210> 25229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25229
atgtctttct tgcttattaa                                                   20


<210> 25230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25230
ttaaattaaa agatggataa                                                   20


<210> 25231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25231
tacacaatta aattaaaaga                                                   20


<210> 25232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25232
aaactacaca attaaattaa                                                   20


<210> 25233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25233
atgattcaag aacacaatta                                                   20


<210> 25234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25234
attttactcc ttaatgattc                                                   20


<210> 25235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25235
atgtgtggat ttcttctcaa                                                   20


<210> 25236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25236
tatgtgtgga tttcttctca                                                   20


<210> 25237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25237
tgccacatag taactatgtg                                                   20


<210> 25238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25238
tattggactc ttatgccaca                                                   20


<210> 25239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25239
atgggaaact tggaaaatat                                                   20


<210> 25240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25240
ctgtaacata atgggaaact                                                   20


<210> 25241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25241
tagttgtcct gtaacataat                                                   20


<210> 25242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25242
ctagttgtcc tgtaacataa                                                   20


<210> 25243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25243
gaagagagta tttaaacatc                                                   20


<210> 25244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25244
ttttgttcta caccagaaga                                                   20


<210> 25245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25245
atttttgttc tacaccagaa                                                   20


<210> 25246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25246
ttatttttgt tctacaccag                                                   20


<210> 25247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25247
aggttatttt tgttctacac                                                   20


<210> 25248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25248
atgattgcaa gagagaagaa                                                   20


<210> 25249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25249
aatgattgca agagagaaga                                                   20


<210> 25250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25250
cctgaatgat tgcaagagag                                                   20


<210> 25251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25251
ggccctgaat gattgcaaga                                                   20


<210> 25252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25252
aaggccctga atgattgcaa                                                   20


<210> 25253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25253
taaaggccct gaatgattgc                                                   20


<210> 25254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25254
ctccagaagg aaaaaaataa                                                   20


<210> 25255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25255
tctccagaag gaaaaaaata                                                   20


<210> 25256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25256
aatgttcaca tttctccaga                                                   20


<210> 25257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25257
taatgttcac atttctccag                                                   20


<210> 25258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25258
ggataatgtt cacatttctc                                                   20


<210> 25259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25259
aattttaaaa actctataag                                                   20


<210> 25260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25260
caattttaaa aactctataa                                                   20


<210> 25261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25261
tccaatttta aaaactctat                                                   20


<210> 25262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25262
ctcaagatga aaagcactaa                                                   20


<210> 25263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25263
gtgattacac tcaagatgaa                                                   20


<210> 25264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25264
taagaaatgt gattacactc                                                   20


<210> 25265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25265
ccagaaatct aaatcatgtt                                                   20


<210> 25266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25266
tgtagagacc tcaaggggcc                                                   20


<210> 25267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25267
aagattgtag agacctcaag                                                   20


<210> 25268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25268
aaagattgta gagacctcaa                                                   20


<210> 25269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25269
aaaagattgt agagacctca                                                   20


<210> 25270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25270
aaaaagattg tagagacctc                                                   20


<210> 25271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25271
atcaaaaaaa aaagattgta                                                   20


<210> 25272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25272
atatcaaaaa aaaaagattg                                                   20


<210> 25273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25273
aaatttcata tcaaaaaaaa                                                   20


<210> 25274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25274
taccttttaa aaagaatctt                                                   20


<210> 25275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25275
ttgaggcatt accttttaaa                                                   20


<210> 25276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25276
ttcagtgatt ttttaacttg                                                   20


<210> 25277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25277
cttcagtgat tttttaactt                                                   20


<210> 25278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25278
ttcctgaaat tcctgagctt                                                   20


<210> 25279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25279
atttttttcc tgaaattcct                                                   20


<210> 25280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25280
ccactgatca ataatatctg                                                   20


<210> 25281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25281
ttccactgat caataatatc                                                   20


<210> 25282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25282
caacagaaga aaatacagtt                                                   20


<210> 25283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25283
ttagacaaca gaagaaaata                                                   20


<210> 25284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25284
cattaaaact tagacaacag                                                   20


<210> 25285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25285
taacattaaa acttagacaa                                                   20


<210> 25286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25286
gtggaagtaa cattaaaact                                                   20


<210> 25287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25287
attttctgct aaattagtgg                                                   20


<210> 25288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25288
acaattttct gctaaattag                                                   20


<210> 25289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25289
ctgacaattt tctgctaaat                                                   20


<210> 25290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25290
agcccagaat ttattgcaac                                                   20


<210> 25291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25291
ccataattag aatgtgagcc                                                   20


<210> 25292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25292
gttgcccata attagaatgt                                                   20


<210> 25293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25293
aagttttagt tgcccataat                                                   20


<210> 25294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25294
taaaaaaaga gctaaagttt                                                   20


<210> 25295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25295
tttttttaaa aaaagagcta                                                   20


<210> 25296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25296
ttgccctttt tttaaaaaaa                                                   20


<210> 25297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25297
tcttgccctt tttttaaaaa                                                   20


<210> 25298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25298
aataggaaag gaaaaaaaat                                                   20


<210> 25299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25299
tagacaaaga aaaataggaa                                                   20


<210> 25300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25300
atagacaaag aaaaatagga                                                   20


<210> 25301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25301
agcaatagac aaagaaaaat                                                   20


<210> 25302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25302
tagcaataga caaagaaaaa                                                   20


<210> 25303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25303
ttctctgcta gcaatagaca                                                   20


<210> 25304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25304
caatatttct ctgctagcaa                                                   20


<210> 25305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25305
cctacacaat atttctctgc                                                   20


<210> 25306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25306
ataagtagct attcctccca                                                   20


<210> 25307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25307
gaataagtag ctattcctcc                                                   20


<210> 25308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25308
tgtgtttcac gctgaataag                                                   20


<210> 25309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25309
ctgtgtgttt cacgctgaat                                                   20


<210> 25310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25310
atatcatgtt gaccttgtga                                                   20


<210> 25311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25311
tgacctcatt atttcaccaa                                                   20


<210> 25312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25312
gaatttctct ggtggtggct                                                   20


<210> 25313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25313
attctgaatt tctctggtgg                                                   20


<210> 25314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25314
tttattctga atttctctgg                                                   20


<210> 25315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25315
ggttttattc tgaatttctc                                                   20


<210> 25316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25316
agaggtctcc gtgaaatcac                                                   20


<210> 25317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25317
aagattctga gaaaaagaag                                                   20


<210> 25318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25318
gaagattctg agaaaaagaa                                                   20


<210> 25319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25319
tagaagattc tgagaaaaag                                                   20


<210> 25320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25320
aggtagaaga ttctgagaaa                                                   20


<210> 25321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25321
tgccctaggt agaagattct                                                   20


<210> 25322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25322
atagaaagtg ccctaggtag                                                   20


<210> 25323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25323
tggatagaaa gtgccctagg                                                   20


<210> 25324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25324
tattggatag aaagtgccct                                                   20


<210> 25325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25325
ttattggata gaaagtgccc                                                   20


<210> 25326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25326
ttttcatgtt attggataga                                                   20


<210> 25327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25327
taagttttca tgttattgga                                                   20


<210> 25328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25328
cacgtaagtt ttcatgttat                                                   20


<210> 25329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25329
atcttatcat ttagtcacgt                                                   20


<210> 25330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25330
tatattcata tcttatcatt                                                   20


<210> 25331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25331
gccagtctag ccttcttaca                                                   20


<210> 25332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25332
tgagaaatct gtagccagtc                                                   20


<210> 25333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25333
ctggctgaga aatctgtagc                                                   20


<210> 25334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25334
ggacctggct gagaaatctg                                                   20


<210> 25335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25335
tgatactata ggacctggct                                                   20


<210> 25336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25336
caagatgata ctataggacc                                                   20


<210> 25337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25337
atgcttcaag atgatactat                                                   20


<210> 25338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25338
gatgcttcaa gatgatacta                                                   20


<210> 25339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25339
tttcattaga aagatgcttc                                                   20


<210> 25340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25340
cttctcttct tttcattaga                                                   20


<210> 25341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25341
tttgcttctc ttcttttcat                                                   20


<210> 25342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25342
caatggccac tttacactcc                                                   20


<210> 25343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25343
agagagccct tgaatatcaa                                                   20


<210> 25344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25344
tctgtgacag agcacagaga                                                   20


<210> 25345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25345
gttctgtgac agagcacaga                                                   20


<210> 25346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25346
cagttctgtg acagagcaca                                                   20


<210> 25347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25347
agcagttctg tgacagagca                                                   20


<210> 25348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25348
agtgtagcag ttctgtgaca                                                   20


<210> 25349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25349
acagtgtagc agttctgtga                                                   20


<210> 25350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25350
tttctctgca aacagtgtag                                                   20


<210> 25351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25351
tgctttctct gcaaacagtg                                                   20


<210> 25352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25352
ccagctgctt tctctgcaaa                                                   20


<210> 25353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25353
tgacttgacc cactgtattc                                                   20


<210> 25354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25354
tgtttgcttc taaagacttt                                                   20


<210> 25355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25355
tgtttaaatg tttgcttcta                                                   20


<210> 25356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25356
tttttttaag ctggcataaa                                                   20


<210> 25357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25357
cttgttgcat ttttttaagc                                                   20


<210> 25358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25358
cctacttgtt gcattttttt                                                   20


<210> 25359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25359
ctttgccttt atgtttgcta                                                   20


<210> 25360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25360
actttgcctt tatgtttgct                                                   20


<210> 25361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25361
agataatatt tacgaagctt                                                   20


<210> 25362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25362
aattatagat aatatttacg                                                   20


<210> 25363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25363
tcttgtttgt ttcaaaatta                                                   20


<210> 25364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25364
aaatgattca gatatctagg                                                   20


<210> 25365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25365
cagaaatgat tcagatatct                                                   20


<210> 25366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25366
acagaaatga ttcagatatc                                                   20


<210> 25367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25367
agtagttaac agaaatgatt                                                   20


<210> 25368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25368
tgggtagtat tagtagttaa                                                   20


<210> 25369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25369
ttcattgtgg gtagtattag                                                   20


<210> 25370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25370
tccttcattg tgggtagtat                                                   20


<210> 25371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25371
ttgccctcct tcattgtggg                                                   20


<210> 25372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25372
tccttgccct ccttcattgt                                                   20


<210> 25373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25373
ttccttgccc tccttcattg                                                   20


<210> 25374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25374
aatccacatg tttaaaaagc                                                   20


<210> 25375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25375
tagaaatcca catgtttaaa                                                   20


<210> 25376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25376
tctatttata ttttcaatat                                                   20


<210> 25377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25377
agctgcctac ataaaggata                                                   20


<210> 25378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25378
agcaaaagct gcctacataa                                                   20


<210> 25379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25379
tagcaaaagc tgcctacata                                                   20


<210> 25380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25380
gaaatatggc actttagcaa                                                   20


<210> 25381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25381
tgacttgaaa tatggcactt                                                   20


<210> 25382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25382
gttaagaatg acttgaaata                                                   20


<210> 25383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25383
aaaaaactga atattcagtt                                                   20


<210> 25384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25384
taagaaaaaa actgaatatt                                                   20


<210> 25385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25385
taatgaatgg tcatcctctt                                                   20


<210> 25386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25386
atgaggtaca tgttaatgaa                                                   20


<210> 25387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25387
ccaagctgtt agaaaagatg                                                   20


<210> 25388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25388
accaagctgt tagaaaagat                                                   20


<210> 25389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25389
tttttaccaa gctgttagaa                                                   20


<210> 25390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25390
ttactttttt accaagctgt                                                   20


<210> 25391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25391
attcttatta cttttttacc                                                   20


<210> 25392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25392
tagaaatata tatacatgca                                                   20


<210> 25393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25393
atttttgaga aagctatttc                                                   20


<210> 25394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25394
aaaacatata atttttgaga                                                   20


<210> 25395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25395
agataaaaca tataattttt                                                   20


<210> 25396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25396
caatattatc tatataggta                                                   20


<210> 25397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25397
acacccaata ttatctatat                                                   20


<210> 25398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25398
tacacccaat attatctata                                                   20


<210> 25399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25399
cttcaactag agcctaaata                                                   20


<210> 25400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25400
tcttcaacta gagcctaaat                                                   20


<210> 25401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25401
tggtgaattt tcttcaacta                                                   20


<210> 25402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25402
tatggtgaat tttcttcaac                                                   20


<210> 25403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25403
aactatttta ttccagaata                                                   20


<210> 25404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25404
catagaaaac tattttattc                                                   20


<210> 25405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25405
atttagaggc aatattctca                                                   20


<210> 25406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25406
caaatttggt ggggatttag                                                   20


<210> 25407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25407
tcaaatttgg tggggattta                                                   20


<210> 25408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25408
tttcaaattt ggtggggatt                                                   20


<210> 25409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25409
tttctatttc aaatttggtg                                                   20


<210> 25410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25410
ttttctattt caaatttggt                                                   20


<210> 25411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25411
tttttctatt tcaaatttgg                                                   20


<210> 25412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25412
atatttttct atttcaaatt                                                   20


<210> 25413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25413
tttaaaggtg gcctaagtaa                                                   20


<210> 25414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25414
gataatttta aaggtggcct                                                   20


<210> 25415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25415
tttgaagata attttaaagg                                                   20


<210> 25416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25416
ttatttgaag ataattttaa                                                   20


<210> 25417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25417
tttatttgaa gataatttta                                                   20


<210> 25418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25418
ttagtgttcc agtttatttg                                                   20


<210> 25419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25419
aattagttat tttagtgttc                                                   20


<210> 25420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25420
aaatgaaaaa ttagttattt                                                   20


<210> 25421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25421
aacagtttca aatgaaaaat                                                   20


<210> 25422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25422
cttagagata atattgctaa                                                   20


<210> 25423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25423
cctgaaattg acacacctta                                                   20


<210> 25424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25424
atcctgaaat tgacacacct                                                   20


<210> 25425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25425
tatctattgt gcaatgatga                                                   20


<210> 25426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25426
tgaatttctc tgtcattgtt                                                   20


<210> 25427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25427
cttgactcct ttttataatc                                                   20


<210> 25428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25428
gggcaggaat ctctgccaat                                                   20


<210> 25429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25429
aatagttcta ggatgggggc                                                   20


<210> 25430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25430
taatagttct aggatggggg                                                   20


<210> 25431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25431
ctttaatagt tctaggatgg                                                   20


<210> 25432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25432
actttaatag ttctaggatg                                                   20


<210> 25433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25433
aactttaata gttctaggat                                                   20


<210> 25434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25434
gaactttaat agttctagga                                                   20


<210> 25435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25435
gactgaactt taatagttct                                                   20


<210> 25436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25436
tgactgaact ttaatagttc                                                   20


<210> 25437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25437
gttgaatgac tgaactttaa                                                   20


<210> 25438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25438
actaagatat attttaattt                                                   20


<210> 25439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25439
aatgtattaa aatacatact                                                   20


<210> 25440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25440
acttttactg aaattagata                                                   20


<210> 25441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25441
tagaacactt ttactgaaat                                                   20


<210> 25442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25442
tcctatctat caataacaca                                                   20


<210> 25443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25443
gaaactaaga ggtttagata                                                   20


<210> 25444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25444
tagaaactaa gaggtttaga                                                   20


<210> 25445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25445
tctctagaaa ctaagaggtt                                                   20


<210> 25446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25446
atcagtctct agaaactaag                                                   20


<210> 25447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25447
gatcagtctc tagaaactaa                                                   20


<210> 25448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25448
cagatcagtc tctagaaact                                                   20


<210> 25449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25449
tacataatca gatcagtctc                                                   20


<210> 25450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25450
gattatatac ataatcagat                                                   20


<210> 25451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25451
tttctgatta tatacataat                                                   20


<210> 25452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25452
tattactcat tgataagaat                                                   20


<210> 25453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25453
aagtaatatt actcattgat                                                   20


<210> 25454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25454
aatgtttaat tttattccag                                                   20


<210> 25455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25455
caaaatgttt aattttattc                                                   20


<210> 25456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25456
cctatgaatg aataagtgat                                                   20


<210> 25457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25457
ggccttgcct atgaatgaat                                                   20


<210> 25458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25458
tgcatcagtt aaaagttgat                                                   20


<210> 25459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25459
atgcatcagt taaaagttga                                                   20


<210> 25460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25460
atataaaatg catcagttaa                                                   20


<210> 25461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25461
tgctcctata taaaatgcat                                                   20


<210> 25462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25462
tttatttttt taaatcaact                                                   20


<210> 25463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25463
ttttatgcac tgttagttat                                                   20


<210> 25464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25464
gttttatgca ctgttagtta                                                   20


<210> 25465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25465
gaaatggttt tatgcactgt                                                   20


<210> 25466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25466
actttgaata cattttgaaa                                                   20


<210> 25467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25467
aagccaaagt accctgcttc                                                   20


<210> 25468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25468
gaaagttggg gtcaaagcca                                                   20


<210> 25469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25469
catctagaaa gttggggtca                                                   20


<210> 25470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25470
agtacacatc tagaaagttg                                                   20


<210> 25471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25471
tagtacacat ctagaaagtt                                                   20


<210> 25472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25472
ttagtacaca tctagaaagt                                                   20


<210> 25473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25473
tttcttagta cacatctaga                                                   20


<210> 25474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25474
atgctttctt agtacacatc                                                   20


<210> 25475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25475
aattgagact catgctttct                                                   20


<210> 25476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25476
tatttatgga taagcaaatt                                                   20


<210> 25477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25477
ctggttatgt atttatggat                                                   20


<210> 25478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25478
taattctggt tatgtattta                                                   20


<210> 25479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25479
agctttgtat ttaataattc                                                   20


<210> 25480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25480
ggaaaagatc attgtaattc                                                   20


<210> 25481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25481
ataaaatctc agagcaggaa                                                   20


<210> 25482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25482
taaatataaa atctcagagc                                                   20


<210> 25483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25483
ataaatataa aatctcagag                                                   20


<210> 25484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25484
ggcataaata taaaatctca                                                   20


<210> 25485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25485
ctggcataaa tataaaatct                                                   20


<210> 25486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25486
aattgtggaa gaagtgtttc                                                   20


<210> 25487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25487
actctaaaaa attgtggaag                                                   20


<210> 25488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25488
aaaactctaa aaaattgtgg                                                   20


<210> 25489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25489
atcaaaactc taaaaaattg                                                   20


<210> 25490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25490
attgtcacat ttaaattaag                                                   20


<210> 25491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25491
taaattgtca catttaaatt                                                   20


<210> 25492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25492
aatctacata aaaatatgga                                                   20


<210> 25493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25493
ttaatctaca taaaaatatg                                                   20


<210> 25494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25494
atttaatcta cataaaaata                                                   20


<210> 25495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25495
gaatgtaaca gtagccattg                                                   20


<210> 25496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25496
taaaatgcag aatgtaacag                                                   20


<210> 25497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25497
aagtaaaatg cagaatgtaa                                                   20


<210> 25498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25498
ttgattataa aagtaaaatg                                                   20


<210> 25499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25499
ttttattgaa ttgattataa                                                   20


<210> 25500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25500
gatttcaagt gcatgatctg                                                   20


<210> 25501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25501
tcatgtgctt aagtgatttc                                                   20


<210> 25502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25502
gatgtaacct tcatgtgctt                                                   20


<210> 25503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25503
gacatcacag catgtcacca                                                   20


<210> 25504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25504
tgacatcaca gcatgtcacc                                                   20


<210> 25505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25505
gtgacatcac agcatgtcac                                                   20


<210> 25506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25506
caatagataa agtgacatca                                                   20


<210> 25507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25507
atacagttgt tcaatagata                                                   20


<210> 25508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25508
aaacatatac agttgttcaa                                                   20


<210> 25509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25509
caagaaagta gaaacatata                                                   20


<210> 25510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25510
cctgacccac tgcaagaaag                                                   20


<210> 25511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25511
ctgcctgacc cactgcaaga                                                   20


<210> 25512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25512
ctttctgcct gacccactgc                                                   20


<210> 25513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25513
tcaatgtctt gcatgctgtt                                                   20


<210> 25514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25514
atatgtcacc acttttacac                                                   20


<210> 25515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25515
catatgtcac cacttttaca                                                   20


<210> 25516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25516
tctgtgcttt taaccaggca                                                   20


<210> 25517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25517
gctctgtgct tttaaccagg                                                   20


<210> 25518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25518
gcagctctgt gcttttaacc                                                   20


<210> 25519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25519
tgcagctctg tgcttttaac                                                   20


<210> 25520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25520
aactggatca gtcaaggatg                                                   20


<210> 25521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25521
atatcaaact ggatcagtca                                                   20


<210> 25522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25522
aatatcaaac tggatcagtc                                                   20


<210> 25523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25523
ggggtaatat caaactggat                                                   20


<210> 25524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25524
tcacaggggt aatatcaaac                                                   20


<210> 25525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25525
acctaacctt cttctcacag                                                   20


<210> 25526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25526
tacctaacct tcttctcaca                                                   20


<210> 25527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25527
gtacctaacc ttcttctcac                                                   20


<210> 25528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25528
agtacctaac cttcttctca                                                   20


<210> 25529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25529
catgctgcat ttctaaaatt                                                   20


<210> 25530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25530
actttaaaca ttttaaaaca                                                   20


<210> 25531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25531
tgtaactaat ttctacttac                                                   20


<210> 25532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25532
atgtaactaa tttctactta                                                   20


<210> 25533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25533
attgcttaac gttgagtata                                                   20


<210> 25534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25534
caaatatatt gcttaacgtt                                                   20


<210> 25535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25535
tgttgaatga catttaatct                                                   20


<210> 25536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25536
ctgtttaatt gattgttttt                                                   20


<210> 25537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25537
tcaattttta aatagtagag                                                   20


<210> 25538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25538
aattcaattt ttaaatagta                                                   20


<210> 25539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25539
taaattcaat ttttaaatag                                                   20


<210> 25540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25540
atttaaattc aatttttaaa                                                   20


<210> 25541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25541
aacattgcat tagcacatta                                                   20


<210> 25542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25542
tagaatgcaa aacattgcat                                                   20


<210> 25543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25543
tgcttgcatt taaggaaaaa                                                   20


<210> 25544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25544
ttaaatgttg cttgcattta                                                   20


<210> 25545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25545
tttaaatgtt gcttgcattt                                                   20


<210> 25546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25546
gccacctcac cccctatact                                                   20


<210> 25547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25547
attttagaat atgcttttta                                                   20


<210> 25548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25548
caatcaagaa atgctaattt                                                   20


<210> 25549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25549
taaataaaaa taagtcaatc                                                   20


<210> 25550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25550
aaaattaatt aaataaaaat                                                   20


<210> 25551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25551
tctttatatt ttgataaatt                                                   20


<210> 25552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25552
aaaaatcttt ccatcttcat                                                   20


<210> 25553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25553
tttttttcag gttgtttcca                                                   20


<210> 25554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25554
ttagaccatt tgtttttttc                                                   20


<210> 25555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25555
cttagaccat ttgttttttt                                                   20


<210> 25556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25556
ctcttctgta gaattgcact                                                   20


<210> 25557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25557
tttttaaaag cactcttctg                                                   20


<210> 25558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25558
tatgcataga ttttttttaa                                                   20


<210> 25559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25559
ttgattctat attttatgca                                                   20


<210> 25560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25560
gttatgctgt ttcgtaaaat                                                   20


<210> 25561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25561
aaagatttag ggattagtta                                                   20


<210> 25562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25562
actttgaaag atttagggat                                                   20


<210> 25563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25563
atttgacttt gaaagattta                                                   20


<210> 25564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25564
catttgactt tgaaagattt                                                   20


<210> 25565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25565
gcatttgact ttgaaagatt                                                   20


<210> 25566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25566
aaaaatgcat ttgactttga                                                   20


<210> 25567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25567
ttctgcttat tactacactt                                                   20


<210> 25568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25568
tagattttta atcaaagttt                                                   20


<210> 25569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25569
tctctttaga tttttaatca                                                   20


<210> 25570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25570
ttatcaagac tttctctctt                                                   20


<210> 25571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25571
gttttaatta cactgttatc                                                   20


<210> 25572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25572
aatgtccttt tactatgtgg                                                   20


<210> 25573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25573
tttaatgtcc ttttactatg                                                   20


<210> 25574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25574
aaaagttgtt tcaatatttg                                                   20


<210> 25575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25575
cattttgttg acctgataaa                                                   20


<210> 25576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25576
atgcttatta ttatgaaatg                                                   20


<210> 25577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25577
ttacaaagtc attatctttg                                                   20


<210> 25578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25578
gtttacaaag tcattatctt                                                   20


<210> 25579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25579
tattcagtgt tcagtttaca                                                   20


<210> 25580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25580
ccattcatct attcagtgtt                                                   20


<210> 25581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25581
tatccaccca ttcatctatt                                                   20


<210> 25582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25582
gaaatctcag gcagaggaac                                                   20


<210> 25583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25583
cagaaggaaa tctcaggcag                                                   20


<210> 25584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25584
acagaaggaa atctcaggca                                                   20


<210> 25585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25585
gtacagaagg aaatctcagg                                                   20


<210> 25586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25586
gtggtacaga aggaaatctc                                                   20


<210> 25587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25587
tgtggtacag aaggaaatct                                                   20


<210> 25588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25588
ctgggcagat gtggtacaga                                                   20


<210> 25589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25589
actgggcaga tgtggtacag                                                   20


<210> 25590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25590
ttcactgggc agatgtggta                                                   20


<210> 25591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25591
aaaatttcac tgggcagatg                                                   20


<210> 25592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25592
atggagaaaa tttcactggg                                                   20


<210> 25593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25593
agtatggaga aaatttcact                                                   20


<210> 25594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25594
cagtatggag aaaatttcac                                                   20


<210> 25595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25595
agaccagacc ttacagtatg                                                   20


<210> 25596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25596
ttagaccaga ccttacagta                                                   20


<210> 25597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25597
ggcacttaga ccagacctta                                                   20


<210> 25598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25598
aaaggaggtg gcacttagac                                                   20


<210> 25599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25599
acatgaaagg aggtggcact                                                   20


<210> 25600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25600
tgacttcaca tgaaaggagg                                                   20


<210> 25601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25601
ggctgacttc acatgaaagg                                                   20


<210> 25602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25602
tggctgactt cacatgaaag                                                   20


<210> 25603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25603
tctggctgac ttcacatgaa                                                   20


<210> 25604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25604
atctggctga cttcacatga                                                   20


<210> 25605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25605
attgagtaag gggctgtatc                                                   20


<210> 25606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25606
ttgaggatgc attgagtaag                                                   20


<210> 25607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25607
attgaggatg cattgagtaa                                                   20


<210> 25608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25608
cattgaggat gcattgagta                                                   20


<210> 25609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25609
ccattgagga tgcattgagt                                                   20


<210> 25610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25610
tagtccattg aggatgcatt                                                   20


<210> 25611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25611
gacactaaac tagtccattg                                                   20


<210> 25612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25612
ggacactaaa ctagtccatt                                                   20


<210> 25613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25613
tccgtaacag gacactaaac                                                   20


<210> 25614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25614
agcaaagcac aatccgtaac                                                   20


<210> 25615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25615
aagcaaagca caatccgtaa                                                   20


<210> 25616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25616
ttataacaca gaacaaagca                                                   20


<210> 25617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25617
aaaaattata acacagaaca                                                   20


<210> 25618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25618
atatacaaaa aattataaca                                                   20


<210> 25619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25619
actctaatag cttgcacctt                                                   20


<210> 25620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25620
cactctaata gcttgcacct                                                   20


<210> 25621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25621
acaaaaagta tacactctaa                                                   20


<210> 25622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25622
gattgatcat tgacaacaaa                                                   20


<210> 25623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25623
tcatgtactt caaaggtaaa                                                   20


<210> 25624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25624
ttcatgtact tcaaaggtaa                                                   20


<210> 25625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25625
cttcatgtac ttcaaaggta                                                   20


<210> 25626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25626
aaaaacttca tgtacttcaa                                                   20


<210> 25627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25627
taaaaacttc atgtacttca                                                   20


<210> 25628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25628
tttggccccc tataaatatt                                                   20


<210> 25629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25629
ttacactcat gaaatatttt                                                   20


<210> 25630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25630
ccagaattat aataggcata                                                   20


<210> 25631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25631
gcccagaatt ataataggca                                                   20


<210> 25632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25632
tctctgccca gaattataat                                                   20


<210> 25633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25633
ctctctgccc agaattataa                                                   20


<210> 25634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25634
attttctatg actctctgcc                                                   20


<210> 25635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25635
tcttttattt gtgcatagta                                                   20


<210> 25636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25636
tttcttttat ttgtgcatag                                                   20


<210> 25637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25637
tcatttcttt tatttgtgca                                                   20


<210> 25638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25638
aaatattatg ttactgaaca                                                   20


<210> 25639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25639
tcaacataat acaaaggcat                                                   20


<210> 25640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25640
tgtggctcaa cataatacaa                                                   20


<210> 25641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25641
atgtggctca acataataca                                                   20


<210> 25642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25642
caaaaactag aaatttcatg                                                   20


<210> 25643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25643
catttttaat ctgcaaaaac                                                   20


<210> 25644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25644
tatgaaaata agaatatttt                                                   20


<210> 25645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25645
tagaaaatat atatgaaaat                                                   20


<210> 25646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25646
ttaattttta cttattgaat                                                   20


<210> 25647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25647
ataaaattac caaaaaacaa                                                   20


<210> 25648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25648
tgcagttact aggcataatt                                                   20


<210> 25649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25649
ttttaagaga tgcagttact                                                   20


<210> 25650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25650
attttaagag atgcagttac                                                   20


<210> 25651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25651
attttctatt ttaagagatg                                                   20


<210> 25652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25652
atggtaattt tctattttaa                                                   20


<210> 25653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25653
ggatggtaat tttctatttt                                                   20


<210> 25654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25654
atgtcaaaag aattgaagga                                                   20


<210> 25655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25655
gaaaatgtca aaagaattga                                                   20


<210> 25656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25656
tgaaaatgtc aaaagaattg                                                   20


<210> 25657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25657
ttcctttatg aaaatgtcaa                                                   20


<210> 25658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25658
tggaaggtat taacaaggtc                                                   20


<210> 25659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25659
ttggaaggta ttaacaaggt                                                   20


<210> 25660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25660
taccttggaa ggtattaaca                                                   20


<210> 25661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25661
ataccttgga aggtattaac                                                   20


<210> 25662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25662
tcttggtaag ataccttgga                                                   20


<210> 25663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25663
ctcttggtaa gataccttgg                                                   20


<210> 25664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25664
attctcttgg taagatacct                                                   20


<210> 25665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25665
aaaatctgga ttctcttggt                                                   20


<210> 25666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25666
gaataaaatc tggattctct                                                   20


<210> 25667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25667
ttgctaccct gaataaaatc                                                   20


<210> 25668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25668
ctgaggcagg acatttatct                                                   20


<210> 25669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25669
gctgaggcag gacatttatc                                                   20


<210> 25670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25670
caaggtagcc tggctgaggc                                                   20


<210> 25671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25671
acaaggtagc ctggctgagg                                                   20


<210> 25672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25672
acaacaaggt agcctggctg                                                   20


<210> 25673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25673
aacaacaagg tagcctggct                                                   20


<210> 25674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25674
cccctaacaa caaggtagcc                                                   20


<210> 25675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25675
ggccacccct aacaacaagg                                                   20


<210> 25676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25676
catggccacc cctaacaaca                                                   20


<210> 25677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25677
acatggccac ccctaacaac                                                   20


<210> 25678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25678
ttggcaagaa cagtgtgaca                                                   20


<210> 25679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25679
ttatgtctta ttggcaagaa                                                   20


<210> 25680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25680
ttggcttatg tcttattggc                                                   20


<210> 25681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25681
aactttggct tatgtcttat                                                   20


<210> 25682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25682
cagagatcct tatccaactt                                                   20


<210> 25683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25683
ggaagggcaa aactttccca                                                   20


<210> 25684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25684
gaggaagggc aaaactttcc                                                   20


<210> 25685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25685
tatcccactt gcctgaggaa                                                   20


<210> 25686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25686
ctatcccact tgcctgagga                                                   20


<210> 25687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25687
actatcccac ttgcctgagg                                                   20


<210> 25688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25688
atgactatcc cacttgcctg                                                   20


<210> 25689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25689
aatgactatc ccacttgcct                                                   20


<210> 25690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25690
aaagaaatag aacgaagcag                                                   20


<210> 25691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25691
gagaaagaaa tagaacgaag                                                   20


<210> 25692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25692
gtagagaaag aaatagaacg                                                   20


<210> 25693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25693
tacccaggta gagaaagaaa                                                   20


<210> 25694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25694
atccaatacc caggtagaga                                                   20


<210> 25695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25695
ttatatccaa tacccaggta                                                   20


<210> 25696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25696
ctttatatcc aatacccagg                                                   20


<210> 25697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25697
cagctttata tccaataccc                                                   20


<210> 25698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25698
acagctttat atccaatacc                                                   20


<210> 25699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25699
agaggtgact gttccaccta                                                   20


<210> 25700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25700
atattaatgc ctatgattag                                                   20


<210> 25701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25701
tatattaatg cctatgatta                                                   20


<210> 25702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25702
tctatattaa tgcctatgat                                                   20


<210> 25703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25703
ccacgtggcc tccatgtcct                                                   20


<210> 25704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25704
tccacgtggc ctccatgtcc                                                   20


<210> 25705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25705
ccacagatca gcagtccacg                                                   20


<210> 25706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25706
ttaaaacatc cacagatcag                                                   20


<210> 25707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25707
attttaaaac atccacagat                                                   20


<210> 25708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25708
ttcatatttt aaaacatcca                                                   20


<210> 25709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25709
actacattgg cataactgga                                                   20


<210> 25710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25710
cttaactaca ttggcataac                                                   20


<210> 25711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25711
caacagagac ttaactacat                                                   20


<210> 25712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25712
ctgtttaact gcatgcaaca                                                   20


<210> 25713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25713
ctctgtttaa ctgcatgcaa                                                   20


<210> 25714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25714
tttttggcta tttctgagtc                                                   20


<210> 25715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25715
atttttggct atttctgagt                                                   20


<210> 25716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25716
tgttattttt ggctatttct                                                   20


<210> 25717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25717
tgtgtgtgtt ttgttatttt                                                   20


<210> 25718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25718
tattttactt aagggtacat                                                   20


<210> 25719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25719
ctattttact taagggtaca                                                   20


<210> 25720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25720
aataaaccta ttttacttaa                                                   20


<210> 25721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25721
gaataaacct attttactta                                                   20


<210> 25722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25722
tgaataaacc tattttactt                                                   20


<210> 25723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25723
cacaccaagg tacacatgtt                                                   20


<210> 25724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25724
gtacacttac tgccacacca                                                   20


<210> 25725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25725
agtacactta ctgccacacc                                                   20


<210> 25726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25726
aggctatatt aggggctagg                                                   20


<210> 25727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25727
taaggctata ttaggggcta                                                   20


<210> 25728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25728
ttaaggctat attaggggct                                                   20


<210> 25729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25729
attaaggcta tattaggggc                                                   20


<210> 25730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25730
tcacattaag gctatattag                                                   20


<210> 25731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25731
ttcacattaa ggctatatta                                                   20


<210> 25732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25732
tttcacatta aggctatatt                                                   20


<210> 25733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25733
ctttcacatt aaggctatat                                                   20


<210> 25734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25734
ttatattatc tttcacatta                                                   20


<210> 25735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25735
attatattat ctttcacatt                                                   20


<210> 25736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25736
tctcaggaca atgtattaag                                                   20


<210> 25737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25737
ttctctcagg acaatgtatt                                                   20


<210> 25738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25738
ttgaaccttt gtgttctctc                                                   20


<210> 25739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25739
tttgaacctt tgtgttctct                                                   20


<210> 25740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25740
agaaaagtat taaatcaatt                                                   20


<210> 25741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25741
cttattatgt tattacagaa                                                   20


<210> 25742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25742
catgacttat tatgttatta                                                   20


<210> 25743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25743
agtccagatc attgccttta                                                   20


<210> 25744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25744
tcagaaatat cactaaagtc                                                   20


<210> 25745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25745
gtgactcaga aatatcacta                                                   20


<210> 25746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25746
gatgaaattg gcaagtgact                                                   20


<210> 25747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25747
ggcttgttga tgaaattggc                                                   20


<210> 25748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25748
ccctggcttg ttgatgaaat                                                   20


<210> 25749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25749
aagacttatc cagctctccc                                                   20


<210> 25750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25750
tagtgctact aagacttatc                                                   20


<210> 25751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25751
atgaggttct tagtgctact                                                   20


<210> 25752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25752
tgaggtaact atgaggttct                                                   20


<210> 25753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25753
accttgctga ggtaactatg                                                   20


<210> 25754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25754
aaccttgctg aggtaactat                                                   20


<210> 25755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25755
tctaggtgaa aaccttgctg                                                   20


<210> 25756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25756
ctctaggtga aaaccttgct                                                   20


<210> 25757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25757
tgatacattc attcttctct                                                   20


<210> 25758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25758
ctgatacatt cattcttctc                                                   20


<210> 25759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25759
agaccaaatt caagttcttg                                                   20


<210> 25760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25760
aactcatcta gaccaaattc                                                   20


<210> 25761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25761
ataaatatga caaactcatc                                                   20


<210> 25762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25762
aatgcatatt ttatacatta                                                   20


<210> 25763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25763
ccctttcctt tccatttatt                                                   20


<210> 25764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25764
ctagaatata tttctttctc                                                   20


<210> 25765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25765
agtaaaactg attttacttc                                                   20


<210> 25766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25766
ttattccctt ctttattgaa                                                   20


<210> 25767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25767
atgtgtgatt tttatatttt                                                   20


<210> 25768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25768
aatgtgtgat ttttatattt                                                   20


<210> 25769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25769
gattaggtta tagtctacct                                                   20


<210> 25770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25770
aatgctgact gattaggtta                                                   20


<210> 25771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25771
caccttaatg ctgactgatt                                                   20


<210> 25772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25772
ccaccttaat gctgactgat                                                   20


<210> 25773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25773
tgtacatttg ctgattcatt                                                   20


<210> 25774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25774
ttgtacattt gctgattcat                                                   20


<210> 25775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25775
ggtgaaattt tctgttgtaa                                                   20


<210> 25776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25776
ctctgtaatg gtgtaattca                                                   20


<210> 25777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25777
cctctgtaat ggtgtaattc                                                   20


<210> 25778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25778
acctctgtaa tggtgtaatt                                                   20


<210> 25779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25779
tttctgctat acctctgtaa                                                   20


<210> 25780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25780
aaaggcaaga aaatgagtag                                                   20


<210> 25781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25781
tagaaaggca agaaaatgag                                                   20


<210> 25782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25782
ccatagaaag gcaagaaaat                                                   20


<210> 25783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25783
actacatgcc atagaaaggc                                                   20


<210> 25784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25784
ttatactaca tgccatagaa                                                   20


<210> 25785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25785
attatactac atgccataga                                                   20


<210> 25786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25786
aatcattata ctacatgcca                                                   20


<210> 25787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25787
tctttttaaa tttaaacccc                                                   20


<210> 25788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25788
ttagtcatgg acgtatctgg                                                   20


<210> 25789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25789
gttagtcatg gacgtatctg                                                   20


<210> 25790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25790
ggttagtcat ggacgtatct                                                   20


<210> 25791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25791
tggttagtca tggacgtatc                                                   20


<210> 25792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25792
agaaaagatt tggttagtca                                                   20


<210> 25793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25793
agattaagaa aagatttggt                                                   20


<210> 25794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25794
taaaagatta agaaaagatt                                                   20


<210> 25795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25795
cgattctaaa agattaagaa                                                   20


<210> 25796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25796
gactgcgatt ctaaaagatt                                                   20


<210> 25797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25797
gcagatgact gcgattctaa                                                   20


<210> 25798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25798
atataatgca tctatatttg                                                   20


<210> 25799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25799
gtctttgtga cctccttagg                                                   20


<210> 25800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25800
ttcgtctttg tgacctcctt                                                   20


<210> 25801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25801
tttcgtcttt gtgacctcct                                                   20


<210> 25802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25802
cacggataaa atgtatacag                                                   20


<210> 25803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25803
acacacggat aaaatgtata                                                   20


<210> 25804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 25804
agaaagcacg cacacacaca                                                   20


<210> 25805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25805
gaggtggatg caaaagaaga                                                   20


<210> 25806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25806
ttgagaggtg gatgcaaaag                                                   20


<210> 25807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25807
catttgagag gtggatgcaa                                                   20


<210> 25808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25808
gatcaaacac atttgagagg                                                   20


<210> 25809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25809
gcggatcaaa cacatttgag                                                   20


<210> 25810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25810
agcggatcaa acacatttga                                                   20


<210> 25811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25811
acagcggatc aaacacattt                                                   20


<210> 25812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 25812
cagacagcag ctgagaacag                                                   20


<210> 25813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25813
ccacagacag cagctgagaa                                                   20


<210> 25814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25814
cagaaccaca gacagcagct                                                   20


<210> 25815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25815
catgacagaa ccacagacag                                                   20


<210> 25816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25816
cttcatgaca gaaccacaga                                                   20


<210> 25817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25817
tctacttcat gacagaacca                                                   20


<210> 25818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25818
ttagagcatc tacttcatga                                                   20


<210> 25819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25819
aggatgtgga cagtgcctta                                                   20


<210> 25820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25820
gcaggatgtg gacagtgcct                                                   20


<210> 25821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25821
gctggaaagc aggatgtgga                                                   20


<210> 25822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25822
gcttgctgga aagcaggatg                                                   20


<210> 25823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25823
tgagcagctt gctggaaagc                                                   20


<210> 25824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25824
atgagcagct tgctggaaag                                                   20


<210> 25825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25825
ggaatgagca gcttgctgga                                                   20


<210> 25826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25826
tgggggaatg agcagcttgc                                                   20


<210> 25827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25827
ttggcagctg ggggaatgag                                                   20


<210> 25828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25828
cttttggcag ctgggggaat                                                   20


<210> 25829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25829
ccaacacttt tggcagctgg                                                   20


<210> 25830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25830
tccaacactt ttggcagctg                                                   20


<210> 25831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25831
atccaacact tttggcagct                                                   20


<210> 25832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25832
catccaacac ttttggcagc                                                   20


<210> 25833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25833
tcagcatcca acacttttgg                                                   20


<210> 25834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25834
ccttcagcat ccaacacttt                                                   20


<210> 25835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25835
gggattcaga tgtgagcctt                                                   20


<210> 25836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25836
ccaaagaggg attcagatgt                                                   20


<210> 25837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25837
ataaggccca aagagggatt                                                   20


<210> 25838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25838
gccacgataa ggcccaaaga                                                   20


<210> 25839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25839
tgccacgata aggcccaaag                                                   20


<210> 25840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25840
ctgccacgat aaggcccaaa                                                   20


<210> 25841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25841
ttctgccacg ataaggccca                                                   20


<210> 25842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25842
acctcccttc tgccacgata                                                   20


<210> 25843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25843
cacctccctt ctgccacgat                                                   20


<210> 25844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25844
gaagggtata accttggggg                                                   20


<210> 25845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25845
ggagaagggt ataaccttgg                                                   20


<210> 25846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25846
gggagaaggg tataaccttg                                                   20


<210> 25847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25847
ggggagaagg gtataacctt                                                   20


<210> 25848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25848
aggggagaag ggtataacct                                                   20


<210> 25849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25849
tttacctttc caggggagaa                                                   20


<210> 25850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25850
ctttaccttt ccaggggaga                                                   20


<210> 25851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25851
cctttacctt tccaggggag                                                   20


<210> 25852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25852
ctccctttac ctttccaggg                                                   20


<210> 25853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25853
ctctcccttt acctttccag                                                   20


<210> 25854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25854
gctctccctt tacctttcca                                                   20


<210> 25855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25855
ggctctccct ttacctttcc                                                   20


<210> 25856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25856
aggctctccc tttacctttc                                                   20


<210> 25857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25857
ccacaccatt cattggatgc                                                   20


<210> 25858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25858
tccacaccat tcattggatg                                                   20


<210> 25859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25859
ttcttctcca caccattcat                                                   20


<210> 25860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25860
caaaacaaag caagagggtc                                                   20


<210> 25861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25861
ccaaaacaaa gcaagagggt                                                   20


<210> 25862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25862
agttccaaaa caaagcaaga                                                   20


<210> 25863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25863
tagttccaaa acaaagcaag                                                   20


<210> 25864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25864
gtagttccaa aacaaagcaa                                                   20


<210> 25865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25865
gagtagttcc aaaacaaagc                                                   20


<210> 25866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25866
tctggagtag ttccaaaaca                                                   20


<210> 25867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25867
gctgtgacaa ccctctggag                                                   20


<210> 25868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25868
gatgctgtga caaccctctg                                                   20


<210> 25869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25869
ctgatgctgt gacaaccctc                                                   20


<210> 25870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25870
gagatttcgg ctgatcctat                                                   20


<210> 25871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 25871
taaaattgca acagagattt                                                   20


<210> 25872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25872
gaactgttaa aattgcaaca                                                   20


<210> 25873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25873
ttgaactgtt aaaattgcaa                                                   20


<210> 25874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25874
aaattattgg gcagagagag                                                   20


<210> 25875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25875
gcaaaattat tgggcagaga                                                   20


<210> 25876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25876
atgcaaaatt attgggcaga                                                   20


<210> 25877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25877
gcatgcaaaa ttattgggca                                                   20


<210> 25878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25878
aggcatgcaa aattattggg                                                   20


<210> 25879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25879
gtgaggcatg caaaattatt                                                   20


<210> 25880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25880
agtgaggcat gcaaaattat                                                   20


<210> 25881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25881
cgtaacatct gtaaaaagtg                                                   20


<210> 25882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25882
acgtaacatc tgtaaaaagt                                                   20


<210> 25883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25883
cgaaacgtaa catctgtaaa                                                   20


<210> 25884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25884
atttactgag aagtgttttc                                                   20


<210> 25885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25885
gatttactga gaagtgtttt                                                   20


<210> 25886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25886
gaaatctgag atttactgag                                                   20


<210> 25887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25887
agagaaatct gagatttact                                                   20


<210> 25888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25888
caatcctgag agagaaatct                                                   20


<210> 25889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25889
ctgggaaacc aatcctgaga                                                   20


<210> 25890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25890
ccctgggaaa ccaatcctga                                                   20


<210> 25891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25891
ttccctggga aaccaatcct                                                   20


<210> 25892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25892
tgtgtagggg tcagttccct                                                   20


<210> 25893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25893
ttgtgtaggg gtcagttccc                                                   20


<210> 25894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25894
tcacgggatt gtgtaggggt                                                   20


<210> 25895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25895
ttaatcacgg gattgtgtag                                                   20


<210> 25896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25896
attaatcacg ggattgtgta                                                   20


<210> 25897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25897
cattaatcac gggattgtgt                                                   20


<210> 25898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25898
tcattaatca cgggattgtg                                                   20


<210> 25899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25899
tgctaacttt cattaatcac                                                   20


<210> 25900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 25900
atgctaactt tcattaatca                                                   20


<210> 25901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25901
gtcagagttg tagataggtt                                                   20


<210> 25902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25902
agtcagagtt gtagataggt                                                   20


<210> 25903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25903
gaaaagtcag agttgtagat                                                   20


<210> 25904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25904
agaaaagtca gagttgtaga                                                   20


<210> 25905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25905
aagaagaaaa gtcagagttg                                                   20


<210> 25906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25906
taaggaaaga agaaaagtca                                                   20


<210> 25907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25907
cttaaggaaa gaagaaaagt                                                   20


<210> 25908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25908
aaatcttaag gaaagaagaa                                                   20


<210> 25909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25909
aagataaatc ttaaggaaag                                                   20


<210> 25910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25910
ggaaagataa atcttaagga                                                   20


<210> 25911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25911
atatggaaag ataaatctta                                                   20


<210> 25912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25912
tatatggaaa gataaatctt                                                   20


<210> 25913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25913
ctgaacagga ggtatatgga                                                   20


<210> 25914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25914
gaacctgaac aggaggtata                                                   20


<210> 25915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25915
aggcagtgaa cctgaacagg                                                   20


<210> 25916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25916
caggcagtga acctgaacag                                                   20


<210> 25917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25917
tacaggcagt gaacctgaac                                                   20


<210> 25918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25918
gtacaggcag tgaacctgaa                                                   20


<210> 25919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25919
tgaactactt gcagtacagg                                                   20


<210> 25920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25920
atttgaacta cttgcagtac                                                   20


<210> 25921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25921
aatttgaact acttgcagta                                                   20


<210> 25922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25922
tcataaattt gaactacttg                                                   20


<210> 25923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25923
aaatacagag tttaatttgg                                                   20


<210> 25924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25924
gggaaataca gagtttaatt                                                   20


<210> 25925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25925
gaggaggtag gggaaataca                                                   20


<210> 25926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25926
ttgaggaggt aggggaaata                                                   20


<210> 25927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25927
ggagaaaatt gaggaggtag                                                   20


<210> 25928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25928
aggagaaaat tgaggaggta                                                   20


<210> 25929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25929
gaggagaaaa ttgaggaggt                                                   20


<210> 25930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25930
ggaggagaaa attgaggagg                                                   20


<210> 25931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25931
gatggaggag aaaattgagg                                                   20


<210> 25932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25932
tgatggagga gaaaattgag                                                   20


<210> 25933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25933
actgatggag gagaaaattg                                                   20


<210> 25934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25934
cactgatgga ggagaaaatt                                                   20


<210> 25935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25935
ttaagaatac actgatggag                                                   20


<210> 25936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25936
aattaagaat acactgatgg                                                   20


<210> 25937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25937
caattaagaa tacactgatg                                                   20


<210> 25938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25938
tacaattaag aatacactga                                                   20


<210> 25939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25939
agatggttat tgatacaatt                                                   20


<210> 25940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25940
ttttgactta gaagactaga                                                   20


<210> 25941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25941
agaattttga cttagaagac                                                   20


<210> 25942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25942
aacaaagaat tttgacttag                                                   20


<210> 25943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25943
cacaacaaag aattttgact                                                   20


<210> 25944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25944
ttacaattca acccacaaca                                                   20


<210> 25945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25945
gacttcaaca taacttttgg                                                   20


<210> 25946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25946
ggacttcaac ataacttttg                                                   20


<210> 25947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25947
taggacttca acataacttt                                                   20


<210> 25948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25948
cactcaaaca tgccagggtt                                                   20


<210> 25949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25949
acactcaaac atgccagggt                                                   20


<210> 25950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25950
gatcacactc aaacatgcca                                                   20


<210> 25951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25951
agatcacact caaacatgcc                                                   20


<210> 25952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25952
aagatcacac tcaaacatgc                                                   20


<210> 25953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25953
caaagaccat atttccaaat                                                   20


<210> 25954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25954
tcatcttcat tgtgtctgca                                                   20


<210> 25955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25955
gaccccagtt atattggatt                                                   20


<210> 25956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25956
tataaggacc ccagttatat                                                   20


<210> 25957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25957
ttttcttctt ataaggaccc                                                   20


<210> 25958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25958
ctcggtcttt tcttcttata                                                   20


<210> 25959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25959
tctcggtctt ttcttcttat                                                   20


<210> 25960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 25960
agttttctcc ctgtgtgtct                                                   20


<210> 25961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25961
tctctggccc ggtactcacg                                                   20


<210> 25962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 25962
catcatccca atctctggcc                                                   20


<210> 25963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25963
agctgcatca tcccaatctc                                                   20


<210> 25964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25964
ttggcaatcc ttgcagcttg                                                   20


<210> 25965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25965
gaggttgttg gcaatccttg                                                   20


<210> 25966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25966
tttctaactt tggaggttgt                                                   20


<210> 25967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25967
ttgctgcttt ctaactttgg                                                   20


<210> 25968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25968
cttgctgctt tctaactttg                                                   20


<210> 25969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25969
gccttgctgc tttctaactt                                                   20


<210> 25970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25970
atttctctaa aggctctagt                                                   20


<210> 25971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25971
catgatttct ctaaaggctc                                                   20


<210> 25972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25972
caaggccatg atttctctaa                                                   20


<210> 25973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25973
gcaaggccat gatttctcta                                                   20


<210> 25974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25974
ctgaaatcaa ggtctgagca                                                   20


<210> 25975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25975
tctgaaatca aggtctgagc                                                   20


<210> 25976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25976
gaagtctgaa atcaaggtct                                                   20


<210> 25977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25977
aggctagaag tctgaaatca                                                   20


<210> 25978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25978
gaggctagaa gtctgaaatc                                                   20


<210> 25979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25979
ttgccagttc tggaggctag                                                   20


<210> 25980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25980
cttttgccag ttctggaggc                                                   20


<210> 25981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25981
tattcttttg ccagttctgg                                                   20


<210> 25982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25982
ttattctttt gccagttctg                                                   20


<210> 25983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25983
atttattctt ttgccagttc                                                   20


<210> 25984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25984
acagaaattt attcttttgc                                                   20


<210> 25985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25985
aactcagtgg cttacaacaa                                                   20


<210> 25986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 25986
aacaaattag caaaactcag                                                   20


<210> 25987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25987
tgtaacaaat tagcaaaact                                                   20


<210> 25988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25988
ttacggctgt tgtaacaaat                                                   20


<210> 25989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 25989
aaggatgtat tagtttctta                                                   20


<210> 25990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25990
gagctgatcc aaggatgtat                                                   20


<210> 25991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25991
taagattgtg agctgatcca                                                   20


<210> 25992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25992
ataagattgt gagctgatcc                                                   20


<210> 25993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 25993
gtctagatat ataagattgt                                                   20


<210> 25994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 25994
ggctcagggt ctagatatat                                                   20


<210> 25995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 25995
aaatataagg gctcagggtc                                                   20


<210> 25996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25996
agttaaaata taagggctca                                                   20


<210> 25997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 25997
aagttaaaat ataagggctc                                                   20


<210> 25998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 25998
aaagttaaaa tataagggct                                                   20


<210> 25999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 25999
acttgaaagt taaaatataa                                                   20


<210> 26000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26000
aacttgaaag ttaaaatata                                                   20


<210> 26001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26001
taacttgaaa gttaaaatat                                                   20


<210> 26002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26002
taatatcggg attaacttga                                                   20


<210> 26003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26003
agctgcaaca atttaatatc                                                   20


<210> 26004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 26004
cagctgcaac aatttaatat                                                   20


<210> 26005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26005
aaaaagatca tgttctcaca                                                   20


<210> 26006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26006
taagaattgc tgagggaaaa                                                   20


<210> 26007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26007
actgtgctaa gaattgctga                                                   20


<210> 26008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26008
cactgtgcta agaattgctg                                                   20


<210> 26009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26009
gcactgtgct aagaattgct                                                   20


<210> 26010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26010
tatgctctaa gcactgtgct                                                   20


<210> 26011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26011
attacacctt actatgctct                                                   20


<210> 26012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26012
ctcattagaa gccttaaagg                                                   20


<210> 26013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26013
ttcctcatta gaagccttaa                                                   20


<210> 26014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26014
cttcctcatt agaagcctta                                                   20


<210> 26015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26015
gtgaagtgct tcctcattag                                                   20


<210> 26016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26016
gcagtgaagt gcttcctcat                                                   20


<210> 26017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26017
cttttttacc actggcagtg                                                   20


<210> 26018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26018
acaggctttt ttaccactgg                                                   20


<210> 26019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26019
tacacaggct tttttaccac                                                   20


<210> 26020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26020
acattaacaa cacactacac                                                   20


<210> 26021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26021
aacattaaca acacactaca                                                   20


<210> 26022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26022
gaagtgcaat gaagccctcc                                                   20


<210> 26023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26023
ccttctcctg aagtgcaatg                                                   20


<210> 26024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26024
tcagagtcag ccttctcctg                                                   20


<210> 26025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26025
ctgatggctc ttctcagagt                                                   20


<210> 26026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26026
tgaactgatg gctcttctca                                                   20


<210> 26027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26027
actgaactga tggctcttct                                                   20


<210> 26028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26028
gaatgcaggc actgaactga                                                   20


<210> 26029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26029
ttcactgttt ctaagaatgc                                                   20


<210> 26030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26030
tttcactgtt tctaagaatg                                                   20


<210> 26031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26031
atactctttt cactgtttct                                                   20


<210> 26032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26032
gttatctcaa aggtacccat                                                   20


<210> 26033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26033
aagacatgct gttatctcaa                                                   20


<210> 26034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26034
aaagacatgc tgttatctca                                                   20


<210> 26035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26035
agtcagtgtc agaatcaaga                                                   20


<210> 26036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26036
agatagtcag tgtcagaatc                                                   20


<210> 26037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26037
tctgaagaga tagtcagtgt                                                   20


<210> 26038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26038
cacttctctg aagagatagt                                                   20


<210> 26039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26039
atagcacttc tctgaagaga                                                   20


<210> 26040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26040
aacaatagca cttctctgaa                                                   20


<210> 26041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26041
agaacaatag cacttctctg                                                   20


<210> 26042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26042
aacaaatgga aatagaacaa                                                   20


<210> 26043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26043
tctgaggaaa caaatggaaa                                                   20


<210> 26044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26044
aacagttctg aggaaacaaa                                                   20


<210> 26045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26045
aaatatctta aacagttctg                                                   20


<210> 26046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26046
caaatatctt aaacagttct                                                   20


<210> 26047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26047
gtttagtcaa atatcttaaa                                                   20


<210> 26048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26048
atgagttaaa acaaacggtt                                                   20


<210> 26049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 26049
aagagatgag ttaaaacaaa                                                   20


<210> 26050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26050
cagaaaataa ccaaagagat                                                   20


<210> 26051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26051
cttatcagaa aataaccaaa                                                   20


<210> 26052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26052
ctcttatcag aaaataacca                                                   20


<210> 26053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26053
tttacagtaa aacctcttat                                                   20


<210> 26054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26054
aatcaaatca aaatatttta                                                   20


<210> 26055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26055
agacagttaa aaatacactc                                                   20


<210> 26056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26056
gatttcctca acctgataga                                                   20


<210> 26057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26057
gacagatttc ctcaacctga                                                   20


<210> 26058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26058
agtataagtt ttcaggttga                                                   20


<210> 26059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26059
ctctcctagt ataagttttc                                                   20


<210> 26060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26060
gctctcctag tataagtttt                                                   20


<210> 26061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26061
tttcagtgct ctcctagtat                                                   20


<210> 26062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26062
gagaattttc agtgctctcc                                                   20


<210> 26063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26063
cagagtttat ggagaatttt                                                   20


<210> 26064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26064
gtttctcaac agagtttatg                                                   20


<210> 26065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26065
tggtttctca acagagttta                                                   20


<210> 26066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26066
agcatcctgg tttctcaaca                                                   20


<210> 26067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26067
ctagcatcct ggtttctcaa                                                   20


<210> 26068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26068
tcttttatga cctagcatcc                                                   20


<210> 26069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26069
aaaccctctc ttttatgacc                                                   20


<210> 26070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26070
gaacctgcat tttgagcaag                                                   20


<210> 26071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26071
agaacctgca ttttgagcaa                                                   20


<210> 26072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26072
aagaacctgc attttgagca                                                   20


<210> 26073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26073
taagaacctg cattttgagc                                                   20


<210> 26074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26074
tgtttaagaa cctgcatttt                                                   20


<210> 26075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26075
atttcccctt ttgcttgttt                                                   20


<210> 26076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26076
tttctttatt caggggctat                                                   20


<210> 26077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26077
ttttctttat tcaggggcta                                                   20


<210> 26078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26078
atattatttt ctttattcag                                                   20


<210> 26079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26079
gatattattt tctttattca                                                   20


<210> 26080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26080
agatattatt ttctttattc                                                   20


<210> 26081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26081
gagatattat tttctttatt                                                   20


<210> 26082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26082
ttacttggat tcaggtttct                                                   20


<210> 26083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26083
tccctagctt acttggattc                                                   20


<210> 26084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26084
atccctagct tacttggatt                                                   20


<210> 26085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26085
aacttaatcc ctagcttact                                                   20


<210> 26086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26086
aatgatgcca acttaatccc                                                   20


<210> 26087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26087
gttcaaagct atggatctgc                                                   20


<210> 26088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26088
atggtaaatg ttcaaagcta                                                   20


<210> 26089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26089
aaagaaatgg taaatgttca                                                   20


<210> 26090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26090
atggtctcct cacaaagaaa                                                   20


<210> 26091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26091
ttttaaatgg tctcctcaca                                                   20


<210> 26092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26092
aatagctaga agtttttaaa                                                   20


<210> 26093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26093
gtatatttca aaatagctag                                                   20


<210> 26094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26094
gttgtatatt tcaaaatagc                                                   20


<210> 26095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26095
atgtgttgta tatttcaaaa                                                   20


<210> 26096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26096
attgaatcgt tggatgacta                                                   20


<210> 26097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26097
ctattgaatc gttggatgac                                                   20


<210> 26098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26098
ctggtgttct attgaatcgt                                                   20


<210> 26099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26099
gagatagaaa gaataagttc                                                   20


<210> 26100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26100
tacagtgaga tagaaagaat                                                   20


<210> 26101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26101
caaagctaca gtgagataga                                                   20


<210> 26102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26102
ggtacaaagc tacagtgaga                                                   20


<210> 26103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26103
aacaggtaca aagctacagt                                                   20


<210> 26104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26104
ggtcaacagg tacaaagcta                                                   20


<210> 26105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26105
aagattggtc aacaggtaca                                                   20


<210> 26106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26106
gtggggaaag attggtcaac                                                   20


<210> 26107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26107
tgtggggaaa gattggtcaa                                                   20


<210> 26108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26108
agcgaggtgt ggggaaagat                                                   20


<210> 26109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26109
ggaggagcga ggtgtgggga                                                   20


<210> 26110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26110
gcttggagga gcgaggtgtg                                                   20


<210> 26111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26111
ggcttggagg agcgaggtgt                                                   20


<210> 26112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26112
aggcttggag gagcgaggtg                                                   20


<210> 26113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26113
atgggaggct tggaggagcg                                                   20


<210> 26114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26114
gatgggaggc ttggaggagc                                                   20


<210> 26115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26115
ggaggatggg aggcttggag                                                   20


<210> 26116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26116
tcggaggatg ggaggcttgg                                                   20


<210> 26117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26117
atcggaggat gggaggcttg                                                   20


<210> 26118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26118
ttatcggagg atgggaggct                                                   20


<210> 26119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26119
agtggttatc ggaggatggg                                                   20


<210> 26120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26120
tagtggttat cggaggatgg                                                   20


<210> 26121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26121
aatagtggtt atcggaggat                                                   20


<210> 26122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26122
gaatagtggt tatcggagga                                                   20


<210> 26123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26123
agtagaatag tggttatcgg                                                   20


<210> 26124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26124
tagtagaata gtggttatcg                                                   20


<210> 26125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 26125
gatagtagaa tagtggttat                                                   20


<210> 26126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26126
agaagtagat agtagaatag                                                   20


<210> 26127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26127
catagaagta gatagtagaa                                                   20


<210> 26128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26128
gttgtcatag aagtagatag                                                   20


<210> 26129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26129
agggttgtca tagaagtaga                                                   20


<210> 26130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26130
ctaaagggtt gtcatagaag                                                   20


<210> 26131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26131
aatctaaagg gttgtcatag                                                   20


<210> 26132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26132
tggaatctaa agggttgtca                                                   20


<210> 26133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26133
acacatatgt ggaatctaaa                                                   20


<210> 26134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26134
cacacatatg tggaatctaa                                                   20


<210> 26135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26135
tcacacatat gtggaatcta                                                   20


<210> 26136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26136
tcaaatatct cacacatatg                                                   20


<210> 26137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26137
tgaaatcagc caggcacaga                                                   20


<210> 26138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26138
taagtgaaat cagccaggca                                                   20


<210> 26139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26139
tatgttaagt gaaatcagcc                                                   20


<210> 26140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26140
ttatgttaag tgaaatcagc                                                   20


<210> 26141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26141
gacattatgt taagtgaaat                                                   20


<210> 26142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26142
aacctggagg acattatgtt                                                   20


<210> 26143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26143
ggcaacatga atgaacctgg                                                   20


<210> 26144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26144
tggcaacatg aatgaacctg                                                   20


<210> 26145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26145
tgtggcaaca tgaatgaacc                                                   20


<210> 26146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26146
taatgaaatc ctgttatttg                                                   20


<210> 26147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26147
attgaacgcc attcagccat                                                   20


<210> 26148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26148
aagaaaaatt gaacgccatt                                                   20


<210> 26149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26149
tgcataaaga aaatgtacat                                                   20


<210> 26150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26150
cgtaaataaa taaatgcata                                                   20


<210> 26151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26151
ctgcactgtt cacaatagcc                                                   20


<210> 26152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26152
tattgctgca ctgttcacaa                                                   20


<210> 26153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26153
ttgaagagat acagtaaaca                                                   20


<210> 26154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26154
atcagtatgt tgaagagata                                                   20


<210> 26155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26155
aatgaaatca gtatgttgaa                                                   20


<210> 26156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26156
gaaatgaaat cagtatgttg                                                   20


<210> 26157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26157
atatccagat gaaatgaaat                                                   20


<210> 26158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26158
cccaatacta agtaaatatc                                                   20


<210> 26159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26159
gatccagcag tcccaatact                                                   20


<210> 26160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26160
agaattttca tatgatccag                                                   20


<210> 26161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26161
aatagaattt tcatatgatc                                                   20


<210> 26162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26162
gttctttaaa aaattaaaaa                                                   20


<210> 26163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26163
cattatggaa agtaatatgg                                                   20


<210> 26164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26164
ccattatgga aagtaatatg                                                   20


<210> 26165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26165
accattatgg aaagtaatat                                                   20


<210> 26166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26166
caccattatg gaaagtaata                                                   20


<210> 26167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26167
attagtacca ccattatgga                                                   20


<210> 26168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26168
gtaaattagt accaccatta                                                   20


<210> 26169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26169
ctgattgtga gaatgtaaat                                                   20


<210> 26170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26170
aatccttaca cactgattgt                                                   20


<210> 26171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26171
tttaaaggat atggagaaaa                                                   20


<210> 26172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26172
gtttaaagga tatggagaaa                                                   20


<210> 26173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26173
tgtttaaagg atatggagaa                                                   20


<210> 26174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26174
ataagtgttt aaaggatatg                                                   20


<210> 26175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26175
atataagtgt ttaaaggata                                                   20


<210> 26176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26176
caaaagatat aagtgtttaa                                                   20


<210> 26177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26177
tcaaaagata taagtgttta                                                   20


<210> 26178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26178
atcaaaaaat caaaagatat                                                   20


<210> 26179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26179
ggctaccatc aaaaaatcaa                                                   20


<210> 26180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26180
tctcctcacc ctagttaaaa                                                   20


<210> 26181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26181
cttgaggtat ctcctcaccc                                                   20


<210> 26182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26182
tgcaaatcaa acctatcttg                                                   20


<210> 26183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26183
atgcaaatca aacctatctt                                                   20


<210> 26184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26184
ctcaacatca ctaatcacca                                                   20


<210> 26185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26185
gctcaacatc actaatcacc                                                   20


<210> 26186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26186
tgctcaacat cactaatcac                                                   20


<210> 26187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26187
agaagacaaa gaaatgccaa                                                   20


<210> 26188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26188
atatttctca aaagaagaca                                                   20


<210> 26189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26189
gaatagatat ttctcaaaag                                                   20


<210> 26190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26190
cctgaataga tatttctcaa                                                   20


<210> 26191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26191
aaatggacaa aagacctgaa                                                   20


<210> 26192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26192
aataattcaa aaatggacaa                                                   20


<210> 26193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26193
aaaaacaaat aattcaaaaa                                                   20


<210> 26194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26194
gttaatatct aaaacataca                                                   20


<210> 26195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26195
ggttaatatc taaaacatac                                                   20


<210> 26196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26196
taaactatgc atctgataat                                                   20


<210> 26197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26197
gtaaactatg catctgataa                                                   20


<210> 26198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26198
gaagagataa cctacagaat                                                   20


<210> 26199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26199
tgaagagata acctacagaa                                                   20


<210> 26200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26200
tagagtgaag agataaccta                                                   20


<210> 26201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26201
caaacaatca atagagtgaa                                                   20


<210> 26202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26202
ggcaaacaat caatagagtg                                                   20


<210> 26203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26203
agcaaggcaa acaatcaata                                                   20


<210> 26204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26204
acagcaaggc aaacaatcaa                                                   20


<210> 26205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26205
taaaaagctt ctgcacagca                                                   20


<210> 26206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26206
ctaaaaagct tctgcacagc                                                   20


<210> 26207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26207
taaactaaaa agcttctgca                                                   20


<210> 26208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26208
ttggattata ttaaactaaa                                                   20


<210> 26209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26209
aaaagcaaat atagacaaat                                                   20


<210> 26210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26210
acaggcaaca aaagcaaata                                                   20


<210> 26211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26211
ctaaaaagca caggcaacaa                                                   20


<210> 26212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26212
ggataaaacc taaaaagcac                                                   20


<210> 26213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26213
tggataaaac ctaaaaagca                                                   20


<210> 26214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26214
ttttttggat aaaacctaaa                                                   20


<210> 26215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26215
gttctaggca aggatttttt                                                   20


<210> 26216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26216
tcatgatgtt gttctaggca                                                   20


<210> 26217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26217
ttcatgatgt tgttctaggc                                                   20


<210> 26218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26218
aagcttcatg atgttgttct                                                   20


<210> 26219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26219
aaagcttcat gatgttgttc                                                   20


<210> 26220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26220
gaagaaaaaa aacaggggga                                                   20


<210> 26221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26221
tagagaagaa aaaaaacagg                                                   20


<210> 26222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26222
ttagagaaga aaaaaaacag                                                   20


<210> 26223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26223
attagagaag aaaaaaaaca                                                   20


<210> 26224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26224
tattagagaa gaaaaaaaac                                                   20


<210> 26225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26225
ctattagaga agaaaaaaaa                                                   20


<210> 26226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26226
aaactacaca actattagag                                                   20


<210> 26227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26227
tgaaaactac acaactatta                                                   20


<210> 26228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26228
actgaaaact acacaactat                                                   20


<210> 26229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26229
aaaatagact acttaaatgt                                                   20


<210> 26230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26230
atacacaagt caactcaaaa                                                   20


<210> 26231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26231
ttatctctta ctttatacac                                                   20


<210> 26232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26232
cacatgcaaa agaatgaaat                                                   20


<210> 26233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26233
aactgaatag ccacatgcaa                                                   20


<210> 26234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26234
atggttctgg gcaaactgaa                                                   20


<210> 26235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26235
cctctttagt aaatggttct                                                   20


<210> 26236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26236
gcctctttag taaatggttc                                                   20


<210> 26237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26237
aggacagcct ctttagtaaa                                                   20


<210> 26238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26238
tagagaaagg acagcctctt                                                   20


<210> 26239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26239
tacctataat agagaaagga                                                   20


<210> 26240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26240
caagtaccta taatagagaa                                                   20


<210> 26241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26241
ccaagtacct ataatagaga                                                   20


<210> 26242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26242
ggttccaagt acctataata                                                   20


<210> 26243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26243
aaggttccaa gtacctataa                                                   20


<210> 26244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26244
ctgagttttg acaaggttcc                                                   20


<210> 26245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26245
cagtcaactg agttttgaca                                                   20


<210> 26246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26246
acagtcaact gagttttgac                                                   20


<210> 26247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26247
ctacacatat acagtcaact                                                   20


<210> 26248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26248
gaaataaatc tacacatata                                                   20


<210> 26249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26249
atacataaga atagagagcc                                                   20


<210> 26250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26250
gagcaataca taagaataga                                                   20


<210> 26251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26251
cagagcaata cataagaata                                                   20


<210> 26252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26252
cacagagcaa tacataagaa                                                   20


<210> 26253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26253
agacacacag agcaatacat                                                   20


<210> 26254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26254
tgacataaaa cagacacaca                                                   20


<210> 26255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26255
actgacataa aacagacaca                                                   20


<210> 26256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26256
agaatgatac tgacataaaa                                                   20


<210> 26257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26257
ataaagctat agtaaccaaa                                                   20


<210> 26258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26258
caaaacatac tataaagcta                                                   20


<210> 26259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26259
tgacttcaaa acatactata                                                   20


<210> 26260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26260
aacaaaaaga acaaagctga                                                   20


<210> 26261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26261
aacctggaac aaaaagaaca                                                   20


<210> 26262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26262
cccaagtaac ctggaacaaa                                                   20


<210> 26263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26263
cctaaatagc ccaagtaacc                                                   20


<210> 26264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26264
caaaagaccc taaatagccc                                                   20


<210> 26265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26265
aaaccacaaa agaccctaaa                                                   20


<210> 26266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26266
acatttgtat gaaaccacaa                                                   20


<210> 26267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26267
tttacagaaa aaaaaaaaaa                                                   20


<210> 26268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26268
aataccagtg acattcttta                                                   20


<210> 26269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26269
tgcaatccct atcaaaatac                                                   20


<210> 26270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26270
tattacccaa agcaatctac                                                   20


<210> 26271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26271
atattaccca aagcaatcta                                                   20


<210> 26272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26272
taaaatgtcc atattaccca                                                   20


<210> 26273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26273
gatattccat gttcatggat                                                   20


<210> 26274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26274
ggaaagatat tccatgttca                                                   20


<210> 26275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26275
gaagaggaca caaaaaggga                                                   20


<210> 26276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26276
aattgaagag gacacaaaaa                                                   20


<210> 26277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26277
aaattgaaga ggacacaaaa                                                   20


<210> 26278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26278
gaaattgaag aggacacaaa                                                   20


<210> 26279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26279
attggtgaga gaaattgaag                                                   20


<210> 26280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26280
tattggtgag agaaattgaa                                                   20


<210> 26281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26281
aatattggtg agagaaattg                                                   20


<210> 26282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26282
aaactataaa atattggtga                                                   20


<210> 26283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26283
gaaaactata aaatattggt                                                   20


<210> 26284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26284
caatgaaaac tataaaatat                                                   20


<210> 26285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26285
agaaataaat ttaaacaagg                                                   20


<210> 26286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26286
tagaaataaa tttaaacaag                                                   20


<210> 26287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26287
cctagaaata aatttaaaca                                                   20


<210> 26288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26288
acctagaaat aaatttaaac                                                   20


<210> 26289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26289
gctacaaaaa ataaaatacc                                                   20


<210> 26290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26290
gaaagcaatc ccatttacaa                                                   20


<210> 26291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26291
caaataatct gaaaataaga                                                   20


<210> 26292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26292
acaacaaata atctgaaaat                                                   20


<210> 26293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26293
aatgaattca gtaatgttgg                                                   20


<210> 26294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26294
aaatgaattc agtaatgttg                                                   20


<210> 26295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26295
ataaatgaat tcagtaatgt                                                   20


<210> 26296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26296
gtagatttca taaatgaatt                                                   20


<210> 26297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26297
gaccccatga aaaaaagtag                                                   20


<210> 26298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26298
aatgacccca tgaaaaaaag                                                   20


<210> 26299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26299
tctaatgacc ccatgaaaaa                                                   20


<210> 26300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26300
gatctgatct tagatataga                                                   20


<210> 26301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26301
atgatctgat cttagatata                                                   20


<210> 26302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26302
atatgatctg atcttagata                                                   20


<210> 26303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26303
gtttttatat gatctgatct                                                   20


<210> 26304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26304
catttaaatt ggaaagaagg                                                   20


<210> 26305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26305
ggacatttaa attggaaaga                                                   20


<210> 26306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26306
aggacattta aattggaaag                                                   20


<210> 26307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26307
taaaggacat ttaaattgga                                                   20


<210> 26308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26308
gaaataaagg acatttaaat                                                   20


<210> 26309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26309
caggcaagag aaagaaataa                                                   20


<210> 26310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26310
tcaggcaaga gaaagaaata                                                   20


<210> 26311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26311
cagagcaatc aggcaagaga                                                   20


<210> 26312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26312
tagccagagc aatcaggcaa                                                   20


<210> 26313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26313
tctagccaga gcaatcaggc                                                   20


<210> 26314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26314
aagttctagc cagagcaatc                                                   20


<210> 26315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26315
gaagttctag ccagagcaat                                                   20


<210> 26316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26316
tagtaatgaa gttctagcca                                                   20


<210> 26317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26317
catagtaatg aagttctagc                                                   20


<210> 26318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26318
tcaacatagt aatgaagttc                                                   20


<210> 26319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26319
ttttattcaa catagtaatg                                                   20


<210> 26320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26320
ttcactactt ttattcaaca                                                   20


<210> 26321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26321
ccaagatctg gaacaagata                                                   20


<210> 26322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26322
tccaagatct ggaacaagat                                                   20


<210> 26323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26323
ttctctccaa gatctggaac                                                   20


<210> 26324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26324
aaagctttct ctccaagatc                                                   20


<210> 26325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26325
gagctgaaag ctttctctcc                                                   20


<210> 26326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26326
actaaccagg gaagagctga                                                   20


<210> 26327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26327
acatgatact aaccagggaa                                                   20


<210> 26328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26328
taacatgata ctaaccaggg                                                   20


<210> 26329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26329
agctaacatg atactaacca                                                   20


<210> 26330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26330
cagctaacat gatactaacc                                                   20


<210> 26331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26331
acagctaaca tgatactaac                                                   20


<210> 26332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26332
ggccatatgt aacaaaccca                                                   20


<210> 26333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26333
aacatacctt aatgtaatga                                                   20


<210> 26334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26334
aaacatacct taatgtaatg                                                   20


<210> 26335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26335
tatcaacaaa ttaagtatag                                                   20


<210> 26336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26336
aattatcaac aaattaagta                                                   20


<210> 26337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26337
ataaaaatta tcaacaaatt                                                   20


<210> 26338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26338
aaaaagcatt ttataaaatc                                                   20


<210> 26339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26339
catctcaata gacagagaaa                                                   20


<210> 26340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26340
tataatcatc tcaatagaca                                                   20


<210> 26341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26341
catataatca tctcaataga                                                   20


<210> 26342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26342
aaaccatata atcatctcaa                                                   20


<210> 26343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26343
aactttctat attatatcaa                                                   20


<210> 26344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26344
caaagatgtt tcaacatttg                                                   20


<210> 26345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26345
gaaatcgtcc cagggatgca                                                   20


<210> 26346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26346
ctcaactgga aatcgtccca                                                   20


<210> 26347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26347
gctcaactgg aaatcgtccc                                                   20


<210> 26348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26348
tgctcaactg gaaatcgtcc                                                   20


<210> 26349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26349
gattattcac catgctcaac                                                   20


<210> 26350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26350
aaatccaaca gcctatcaaa                                                   20


<210> 26351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26351
tactagcaac tcaaatccaa                                                   20


<210> 26352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26352
aaaatgcccc aacaaaatac                                                   20


<210> 26353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26353
gccactatcc ctgatgaaca                                                   20


<210> 26354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26354
acacacgaaa agaaagctga                                                   20


<210> 26355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26355
cacacacgaa aagaaagctg                                                   20


<210> 26356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26356
gacacacaca cacgaaaaga                                                   20


<210> 26357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26357
cagggacaca cacacacgaa                                                   20


<210> 26358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26358
cccaatacca gaacaagaca                                                   20


<210> 26359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26359
ccccaatacc agaacaagac                                                   20


<210> 26360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26360
accccaatac cagaacaaga                                                   20


<210> 26361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26361
tattacccca ataccagaac                                                   20


<210> 26362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26362
ggccaatatt accccaatac                                                   20


<210> 26363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26363
tcttctaaat tcattctaca                                                   20


<210> 26364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26364
ttcttctaaa ttcattctac                                                   20


<210> 26365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26365
tccaaaaaaa tcaaaaggaa                                                   20


<210> 26366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26366
ttccaaaaaa atcaaaagga                                                   20


<210> 26367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26367
attattccaa aaaaatcaaa                                                   20


<210> 26368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26368
aattattcca aaaaaatcaa                                                   20


<210> 26369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26369
attctaccaa acatttaaag                                                   20


<210> 26370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26370
tgaattctac caaacattta                                                   20


<210> 26371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26371
aagaaaagtc caggaccaca                                                   20


<210> 26372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26372
ctcctagcaa agaaaagtcc                                                   20


<210> 26373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26373
tctcctagca aagaaaagtc                                                   20


<210> 26374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26374
aaatctctcc tagcaaagaa                                                   20


<210> 26375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26375
taataaaatc tctcctagca                                                   20


<210> 26376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26376
atcagtaata aaatctctcc                                                   20


<210> 26377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26377
aatgagtaac aagattgaat                                                   20


<210> 26378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26378
acagaccaat aatgagtaac                                                   20


<210> 26379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26379
aactcaaaca gaccaataat                                                   20


<210> 26380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26380
gaagaaatgg aaaactcaaa                                                   20


<210> 26381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26381
aagactgtat catgaagaaa                                                   20


<210> 26382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26382
cttgccaaga ctgtatcatg                                                   20


<210> 26383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26383
ctcaacacat acaacttgcc                                                   20


<210> 26384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26384
caacaaattg gaaaacctaa                                                   20


<210> 26385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26385
acaatcatac tccaacaaat                                                   20


<210> 26386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26386
gcagcagcta ctgatcaata                                                   20


<210> 26387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26387
ttgcagcagc tactgatcaa                                                   20


<210> 26388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26388
atcattaaca acgtttgcag                                                   20


<210> 26389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26389
agaatcatta acaacgtttg                                                   20


<210> 26390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26390
cctaaatttg gatgcaactt                                                   20


<210> 26391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26391
ttgaattgtt tgcctaaatt                                                   20


<210> 26392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26392
tttattacaa atgcctgttc                                                   20


<210> 26393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26393
gtgtgtgaaa gacatacttg                                                   20


<210> 26394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26394
agtgtgtgaa agacatactt                                                   20


<210> 26395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26395
tagtgtgtga aagacatact                                                   20


<210> 26396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26396
ttcagaattt tagtgtgtga                                                   20


<210> 26397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26397
agatcagtgc ttcagaattt                                                   20


<210> 26398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26398
cgtgatgaag atcagtgctt                                                   20


<210> 26399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26399
agagatagcg tgatgaagat                                                   20


<210> 26400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26400
ttaaaagaga tagcgtgatg                                                   20


<210> 26401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26401
cagattgaat ttaaaagaga                                                   20


<210> 26402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26402
gttacagatt gaatttaaaa                                                   20


<210> 26403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26403
tggttacaga ttgaatttaa                                                   20


<210> 26404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26404
ctgtaagtag ctattggtta                                                   20


<210> 26405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26405
tacacactgt aagtagctat                                                   20


<210> 26406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26406
gcttatatac acactgtaag                                                   20


<210> 26407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26407
agtgcttata tacacactgt                                                   20


<210> 26408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26408
attattataa gtatggaatt                                                   20


<210> 26409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26409
atgtacaatt attataagta                                                   20


<210> 26410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26410
gctcaatgta caattattat                                                   20


<210> 26411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26411
ttagacaaat gcttattgaa                                                   20


<210> 26412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26412
atatgattct cataaataat                                                   20


<210> 26413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26413
gtgtaaaata gattgtaata                                                   20


<210> 26414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26414
cagtttattt atgtgtaaaa                                                   20


<210> 26415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26415
atttacaaaa acattttttt                                                   20


<210> 26416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26416
ttagcttttg ataagacctt                                                   20


<210> 26417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26417
ctcaaatctt agcttttgat                                                   20


<210> 26418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26418
agaatatttg cctcaaatct                                                   20


<210> 26419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26419
aagaatgcca ctttttaaga                                                   20


<210> 26420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26420
agttaagaat gccacttttt                                                   20


<210> 26421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26421
cactaccttg ggatatagtt                                                   20


<210> 26422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26422
ttagccacta ccttgggata                                                   20


<210> 26423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26423
taagtcttag ccactacctt                                                   20


<210> 26424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26424
ttaagtctta gccactacct                                                   20


<210> 26425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26425
atatttatgt cattaagtct                                                   20


<210> 26426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26426
atttatatat ttatgtcatt                                                   20


<210> 26427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26427
aaattgaatt acccaataga                                                   20


<210> 26428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26428
aggcaaattg aattacccaa                                                   20


<210> 26429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26429
tgagcctgga tgagccaaag                                                   20


<210> 26430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26430
atgagcctgg atgagccaaa                                                   20


<210> 26431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26431
tgatgagcct ggatgagcca                                                   20


<210> 26432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26432
tgtttgtgat gagcctggat                                                   20


<210> 26433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26433
ggttgtgttt gtgatgagcc                                                   20


<210> 26434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26434
gtgatggttg tgtttgtgat                                                   20


<210> 26435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26435
agatgccttt gaaatagtga                                                   20


<210> 26436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26436
tatctgagat gcctttgaaa                                                   20


<210> 26437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26437
cttttatttt tttcgtatct                                                   20


<210> 26438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26438
atctcccact tgagttccca                                                   20


<210> 26439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26439
tcatctccca cttgagttcc                                                   20


<210> 26440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26440
ataatcttca tctcccactt                                                   20


<210> 26441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26441
tcccattcag atcactaaaa                                                   20


<210> 26442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26442
ttttgttttg ttttcccatt                                                   20


<210> 26443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26443
tcttcagatt aaaatgtttc                                                   20


<210> 26444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26444
gtctttcttt ccagcctctt                                                   20


<210> 26445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26445
acatctaagg tctttctttc                                                   20


<210> 26446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26446
ctataaaaac cttacatcta                                                   20


<210> 26447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26447
actataaaaa ccttacatct                                                   20


<210> 26448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26448
tttgataaga tattaagctg                                                   20


<210> 26449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26449
aatttgtttg ataagatatt                                                   20


<210> 26450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26450
ctagaggaaa tttgtttgat                                                   20


<210> 26451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26451
aatgaaggtt caagatctag                                                   20


<210> 26452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26452
taatgaaggt tcaagatcta                                                   20


<210> 26453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26453
aataatgaag gttcaagatc                                                   20


<210> 26454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26454
ttgagaaata atgaaggttc                                                   20


<210> 26455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26455
taagaattga gaaataatga                                                   20


<210> 26456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26456
ataagaattg agaaataatg                                                   20


<210> 26457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26457
tacctgaaaa tataagaatt                                                   20


<210> 26458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26458
acaaacctac ctgaaaatat                                                   20


<210> 26459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26459
aaagtatgtc atattaagta                                                   20


<210> 26460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26460
atctcaaagt atgtcatatt                                                   20


<210> 26461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26461
attttccatg acgtatctca                                                   20


<210> 26462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26462
cttctaatta tgaactttga                                                   20


<210> 26463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26463
tacttaagaa ctcaggttct                                                   20


<210> 26464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26464
ttattattac ttaagaactc                                                   20


<210> 26465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26465
attattatta cttaagaact                                                   20


<210> 26466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26466
ctgcatcatt attattactt                                                   20


<210> 26467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26467
ttagcaagcc attttaaaaa                                                   20


<210> 26468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26468
agcatagtgt ttgaattagc                                                   20


<210> 26469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26469
atgtagcata gtgtttgaat                                                   20


<210> 26470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26470
tatttttaag tcatgtagca                                                   20


<210> 26471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26471
gctagtattt ttaagtcatg                                                   20


<210> 26472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26472
atacacaagc tagtattttt                                                   20


<210> 26473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26473
gtagtaacag atacacaagc                                                   20


<210> 26474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26474
ggttgtagta acagatacac                                                   20


<210> 26475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26475
taccttagag gttgtagtaa                                                   20


<210> 26476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26476
tgtggctacc ttagaggttg                                                   20


<210> 26477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26477
ggagtttgtg gctaccttag                                                   20


<210> 26478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26478
aggagtttgt ggctacctta                                                   20


<210> 26479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26479
acaggagttt gtggctacct                                                   20


<210> 26480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26480
attaaatata caggagtttg                                                   20


<210> 26481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26481
atgcacaatt aaatatacag                                                   20


<210> 26482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26482
gtatgcacaa ttaaatatac                                                   20


<210> 26483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26483
ggtatgcaca attaaatata                                                   20


<210> 26484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26484
cttactctat tacatttcca                                                   20


<210> 26485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26485
gttatatcta tatgataaaa                                                   20


<210> 26486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26486
tggttatatc tatatgataa                                                   20


<210> 26487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26487
atttttttct cattacataa                                                   20


<210> 26488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26488
aatctagtgc cctataaact                                                   20


<210> 26489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26489
ttccgaaagc gtatgaaatc                                                   20


<210> 26490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26490
tattccatga gcccttccga                                                   20


<210> 26491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26491
tactctgtca cttattccat                                                   20


<210> 26492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26492
tttgtatttt ataactgaaa                                                   20


<210> 26493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26493
ggttagctat cttttataac                                                   20


<210> 26494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26494
aggtgtgttg tcataatggt                                                   20


<210> 26495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26495
atgaaggtgt gttgtcataa                                                   20


<210> 26496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26496
tatctgtggc atgcagatga                                                   20


<210> 26497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26497
atatctgtgg catgcagatg                                                   20


<210> 26498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26498
atttatatat ctgtggcatg                                                   20


<210> 26499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26499
ctatagaatt tatatatctg                                                   20


<210> 26500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26500
ggtataaagc catgcagcta                                                   20


<210> 26501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26501
ccctggggta taaagccatg                                                   20


<210> 26502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26502
tttgtctccc ctggggtata                                                   20


<210> 26503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26503
ttaataattt gtctcccctg                                                   20


<210> 26504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26504
cttaataatt tgtctcccct                                                   20


<210> 26505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26505
acttaataat ttgtctcccc                                                   20


<210> 26506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26506
cacaaaacaa acattcctat                                                   20


<210> 26507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26507
gcttgtgact tatagctcaa                                                   20


<210> 26508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26508
agtcctaggc ttgtgactta                                                   20


<210> 26509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26509
agagccatgt caagagtcct                                                   20


<210> 26510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26510
cagagccatg tcaagagtcc                                                   20


<210> 26511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26511
taaaggcaga gccatgtcaa                                                   20


<210> 26512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26512
tataaaggca gagccatgtc                                                   20


<210> 26513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26513
gttatacagt tataaaggca                                                   20


<210> 26514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26514
gagttataca gttataaagg                                                   20


<210> 26515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26515
atagagttat acagttataa                                                   20


<210> 26516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26516
tatagagtta tacagttata                                                   20


<210> 26517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26517
tctagagtta tagagttata                                                   20


<210> 26518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26518
gttataaatc tagagttata                                                   20


<210> 26519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26519
cagttataaa tctagagtta                                                   20


<210> 26520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26520
gttatacagt tataaatcta                                                   20


<210> 26521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26521
gagttataca gttataaatc                                                   20


<210> 26522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26522
gttataaagc tagagttata                                                   20


<210> 26523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26523
tattcacagt tataaagcta                                                   20


<210> 26524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26524
tttattcaca gttataaagc                                                   20


<210> 26525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26525
tgattttatt cacagttata                                                   20


<210> 26526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26526
aaaggaagtg attttattca                                                   20


<210> 26527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26527
aaagcagact cattaaaagg                                                   20


<210> 26528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26528
gaaaaagcag actcattaaa                                                   20


<210> 26529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26529
tgaaaaagca gactcattaa                                                   20


<210> 26530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26530
tcattttcta actgaaaaag                                                   20


<210> 26531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26531
acttcatttt ctaactgaaa                                                   20


<210> 26532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26532
accttataga actttccatt                                                   20


<210> 26533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26533
acatttttaa gggaacctta                                                   20


<210> 26534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26534
ttgagttgca acatttttaa                                                   20


<210> 26535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26535
gttgagttgc aacattttta                                                   20


<210> 26536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26536
tgttgagttg caacattttt                                                   20


<210> 26537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26537
attcttattc ttagtatgtt                                                   20


<210> 26538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26538
gctgacaaaa ttcttattct                                                   20


<210> 26539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26539
tgacctttca tggatctcct                                                   20


<210> 26540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26540
agtcaatggc tgacctttca                                                   20


<210> 26541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26541
tttctttcat ttaaagtcaa                                                   20


<210> 26542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26542
gttcattttt ctttcattta                                                   20


<210> 26543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26543
attatttctt aacatttatg                                                   20


<210> 26544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26544
aattatttct taacatttat                                                   20


<210> 26545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26545
gagctgggga aagtcaacca                                                   20


<210> 26546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26546
agcacttcag gagctgggga                                                   20


<210> 26547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26547
ttaaagcact tcaggagctg                                                   20


<210> 26548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26548
gttaaagcac ttcaggagct                                                   20


<210> 26549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26549
tgttaaagca cttcaggagc                                                   20


<210> 26550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26550
taggtgttaa agcacttcag                                                   20


<210> 26551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26551
tctaggtgtt aaagcacttc                                                   20


<210> 26552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26552
ttctaggtgt taaagcactt                                                   20


<210> 26553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26553
aacttggatt ctaggtgtta                                                   20


<210> 26554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26554
cagaataaaa cttggattct                                                   20


<210> 26555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26555
tcagaataaa acttggattc                                                   20


<210> 26556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26556
gttgctctca gaataaaact                                                   20


<210> 26557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26557
gcctggcaga cagttgctct                                                   20


<210> 26558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26558
aactccaatt gcctggcaga                                                   20


<210> 26559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26559
tataaactcc aattgcctgg                                                   20


<210> 26560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26560
aattataaac tccaattgcc                                                   20


<210> 26561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26561
actctgtcac ccatttaaag                                                   20


<210> 26562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26562
ctaactctgt cacccattta                                                   20


<210> 26563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26563
tatggaaagg gaaactaact                                                   20


<210> 26564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26564
ggtttagtat catatggaaa                                                   20


<210> 26565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26565
aggtttagta tcatatggaa                                                   20


<210> 26566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26566
taggtttagt atcatatgga                                                   20


<210> 26567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26567
catctaggtt tagtatcata                                                   20


<210> 26568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26568
aaggagcagg catctaggtt                                                   20


<210> 26569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26569
cttttaagga gcaggcatct                                                   20


<210> 26570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26570
ccttttaagg agcaggcatc                                                   20


<210> 26571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26571
acgtatgcct tttaaggagc                                                   20


<210> 26572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26572
cacgtatgcc ttttaaggag                                                   20


<210> 26573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26573
ttccacgtat gccttttaag                                                   20


<210> 26574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26574
gattccacgt atgcctttta                                                   20


<210> 26575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26575
agattccacg tatgcctttt                                                   20


<210> 26576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26576
tcagcttaaa gttagaaaat                                                   20


<210> 26577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26577
tgttcatttc agcttaaagt                                                   20


<210> 26578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26578
accgtgttca tttcagctta                                                   20


<210> 26579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26579
ttttaaaacc gtgttcattt                                                   20


<210> 26580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26580
taaaatgttc tacatggaag                                                   20


<210> 26581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26581
ttttaaaatg ttctacatgg                                                   20


<210> 26582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26582
atattttaaa atgttctaca                                                   20


<210> 26583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26583
gacccaggga tacagaaggc                                                   20


<210> 26584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26584
gtgggaccca gggatacaga                                                   20


<210> 26585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26585
tgtgggaccc agggatacag                                                   20


<210> 26586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26586
agatgtggga cccagggata                                                   20


<210> 26587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26587
ctctacagat gtgggaccca                                                   20


<210> 26588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26588
actctacaga tgtgggaccc                                                   20


<210> 26589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26589
gactctacag atgtgggacc                                                   20


<210> 26590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26590
ttggttgact ctacagatgt                                                   20


<210> 26591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26591
gttggttgac tctacagatg                                                   20


<210> 26592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26592
tctgtagttg gttgactcta                                                   20


<210> 26593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26593
aattattttc catctgtagt                                                   20


<210> 26594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26594
ttccaattat tttccatctg                                                   20


<210> 26595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26595
tcagattact tataatgtaa                                                   20


<210> 26596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26596
tgtacacttt aaattatctt                                                   20


<210> 26597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26597
ctcaattcct ttatataaaa                                                   20


<210> 26598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26598
cccacagaga ctaaaatctg                                                   20


<210> 26599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26599
tagtttgaag gccccccaca                                                   20


<210> 26600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26600
agtagtttga aggcccccca                                                   20


<210> 26601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26601
tctatgggcg agtagtttga                                                   20


<210> 26602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26602
atctatgggc gagtagtttg                                                   20


<210> 26603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26603
cctcgatatc tatgggcgag                                                   20


<210> 26604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26604
atccctcgat atctatgggc                                                   20


<210> 26605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26605
agtcatccct cgatatctat                                                   20


<210> 26606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26606
tagtcatccc tcgatatcta                                                   20


<210> 26607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26607
gtaaagtaag gaatcaaatc                                                   20


<210> 26608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26608
ttttccaaga cggtaaagta                                                   20


<210> 26609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26609
tttttccaag acggtaaagt                                                   20


<210> 26610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26610
acattttttc caagacggta                                                   20


<210> 26611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 26611
caaggacatt ttttccaaga                                                   20


<210> 26612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26612
tagccaagga cattttttcc                                                   20


<210> 26613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26613
tatatgtttc tatgtagcca                                                   20


<210> 26614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26614
atatatgttt ctatgtagcc                                                   20


<210> 26615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26615
tcatgatata tgtttctatg                                                   20


<210> 26616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26616
aaaatgctct atatttaatt                                                   20


<210> 26617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26617
taagattaaa ttaaatacat                                                   20


<210> 26618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26618
ctcaaaaaaa atcaatacat                                                   20


<210> 26619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26619
tccagcttgg actacagagt                                                   20


<210> 26620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26620
gcactccagc ttggactaca                                                   20


<210> 26621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26621
ctgcactcca gcttggacta                                                   20


<210> 26622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26622
cgcaccgctg cactccagct                                                   20


<210> 26623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26623
aagatcgcac cgctgcactc                                                   20


<210> 26624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26624
ggcggaggtt gcagtaagcc                                                   20


<210> 26625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26625
ccagaggcgg aggttgcagt                                                   20


<210> 26626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26626
agctccagag gcggaggttg                                                   20


<210> 26627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26627
cacttgagct ccagaggcgg                                                   20


<210> 26628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26628
tcacttgagc tccagaggcg                                                   20


<210> 26629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 26629
aatcacttga gctccagagg                                                   20


<210> 26630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26630
gagaatcact tgagctccag                                                   20


<210> 26631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26631
tgagaatcac ttgagctcca                                                   20


<210> 26632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26632
catgagaatc acttgagctc                                                   20


<210> 26633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26633
ctgaggcatg agaatcactt                                                   20


<210> 26634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26634
tgctcaggag gctgaggcat                                                   20


<210> 26635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26635
gtaaaatgct caggaggctg                                                   20


<210> 26636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26636
agtaaaatgc tcaggaggct                                                   20


<210> 26637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26637
atatcagtaa aatgctcagg                                                   20


<210> 26638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26638
tatatcagta aaatgctcag                                                   20


<210> 26639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26639
tatatatcag taaaatgctc                                                   20


<210> 26640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26640
atatatatca gtaaaatgct                                                   20


<210> 26641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26641
atatatatat atatatatat                                                   20


<210> 26642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26642
acttggaaaa cgagattata                                                   20


<210> 26643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26643
ttatagtgga cttggaaaac                                                   20


<210> 26644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26644
ccatgaattt atagtggact                                                   20


<210> 26645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26645
caccctccat gaatttatag                                                   20


<210> 26646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26646
ctccaccctc catgaattta                                                   20


<210> 26647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26647
ttctatctcc ttaacttact                                                   20


<210> 26648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26648
tcatgttaga aagtatttga                                                   20


<210> 26649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26649
tttctctagc tcatgttaga                                                   20


<210> 26650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26650
ttgttttctc tagctcatgt                                                   20


<210> 26651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26651
aaataatctt ttgttttctc                                                   20


<210> 26652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26652
gagattgctt tcaagtctta                                                   20


<210> 26653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26653
tgagattgct ttcaagtctt                                                   20


<210> 26654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26654
acttttatga gattgctttc                                                   20


<210> 26655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26655
gtattacaaa ttacttttat                                                   20


<210> 26656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26656
agtgagtcaa ggtatgtatt                                                   20


<210> 26657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26657
tgcatatttc tagtgagtca                                                   20


<210> 26658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26658
ctgcatattt ctagtgagtc                                                   20


<210> 26659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26659
cttacctgca tatttctagt                                                   20


<210> 26660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26660
cacccttacc tgcatatttc                                                   20


<210> 26661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26661
actgtaaatt cattgagaac                                                   20


<210> 26662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26662
tactgtaaat tcattgagaa                                                   20


<210> 26663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26663
aatagtactg taaattcatt                                                   20


<210> 26664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26664
aaattatggt atgcatcaaa                                                   20


<210> 26665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26665
tttaattttt tgagaaatta                                                   20


<210> 26666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26666
atcttaaatt ttaatttttt                                                   20


<210> 26667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26667
tttatacttc ttcctggatt                                                   20


<210> 26668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26668
aacaatttta tacttcttcc                                                   20


<210> 26669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26669
aatttctccc caaatggatg                                                   20


<210> 26670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26670
cctcctaatt tctccccaaa                                                   20


<210> 26671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26671
gttaatacat gtaaaatgtt                                                   20


<210> 26672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26672
cttaaatcgc agttgggtca                                                   20


<210> 26673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26673
acttaaatcg cagttgggtc                                                   20


<210> 26674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26674
tacttaaatc gcagttgggt                                                   20


<210> 26675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26675
ttaatactta aatcgcagtt                                                   20


<210> 26676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26676
gttaatactt aaatcgcagt                                                   20


<210> 26677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26677
aattgttaat acttaaatcg                                                   20


<210> 26678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26678
tctccagtca aaatccttca                                                   20


<210> 26679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26679
ttctccagtc aaaatccttc                                                   20


<210> 26680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26680
ttgcttggga tttccttctc                                                   20


<210> 26681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26681
acactctcca cactttgctt                                                   20


<210> 26682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26682
aacactctcc acactttgct                                                   20


<210> 26683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26683
taccaaacca atttcctttt                                                   20


<210> 26684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26684
gtaccaaacc aatttccttt                                                   20


<210> 26685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26685
tatctcctag tgctcaccca                                                   20


<210> 26686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26686
ctttgaccag ctctatctcc                                                   20


<210> 26687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26687
tggccctaac cagctttgac                                                   20


<210> 26688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26688
cttcacacta tggccctaac                                                   20


<210> 26689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26689
tgcacaaagc cttcacacta                                                   20


<210> 26690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26690
cgaattatgt actgtgcaca                                                   20


<210> 26691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26691
accacgcctg gccatcccca                                                   20


<210> 26692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26692
caggagtgag ccaccacgcc                                                   20


<210> 26693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26693
gttgctgaga ttacaggagt                                                   20


<210> 26694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26694
cccagttgct gagattacag                                                   20


<210> 26695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26695
tccccagttg ctgagattac                                                   20


<210> 26696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26696
ttccccagtt gctgagatta                                                   20


<210> 26697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26697
aaactttttc cccagttgct                                                   20


<210> 26698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26698
aattcttcaa actttttccc                                                   20


<210> 26699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26699
ggtctcaaac tactggactc                                                   20


<210> 26700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26700
tggtctcaaa ctactggact                                                   20


<210> 26701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26701
ccaggctggt ctcaaactac                                                   20


<210> 26702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26702
tttcactatg tttcccaggc                                                   20


<210> 26703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26703
aaggtttcac tatgtttccc                                                   20


<210> 26704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26704
caaggtttca ctatgtttcc                                                   20


<210> 26705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26705
taaaaaagtt tgtagagaca                                                   20


<210> 26706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26706
ttaaaaaagt ttgtagagac                                                   20


<210> 26707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26707
tttttttaaa aaagtttgta                                                   20


<210> 26708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26708
aattttttta aaaaagtttg                                                   20


<210> 26709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26709
cccagctaat ttttttaaaa                                                   20


<210> 26710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26710
cacacccatg ccacaacacc                                                   20


<210> 26711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26711
cctccacctc ctgagttgct                                                   20


<210> 26712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26712
gcctccacct cctgagttgc                                                   20


<210> 26713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26713
tcctcctgcc tccacctcct                                                   20


<210> 26714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26714
aaccttgaac tcctgggctc                                                   20


<210> 26715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26715
tactgcaacc ttgaactcct                                                   20


<210> 26716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26716
ttactgcaac cttgaactcc                                                   20


<210> 26717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26717
ggagtacagt ggtgctatca                                                   20


<210> 26718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26718
ttgcccagtc tggagtacag                                                   20


<210> 26719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26719
ctgttgccca gtctggagta                                                   20


<210> 26720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26720
tcactctgtt gcccagtctg                                                   20


<210> 26721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26721
tctcactctg ttgcccagtc                                                   20


<210> 26722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26722
acaggtctca ctctgttgcc                                                   20


<210> 26723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26723
tttttttaaa aaacggagac                                                   20


<210> 26724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26724
ttttttttaa aaaacggaga                                                   20


<210> 26725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26725
cttctttttt ttaaaaaacg                                                   20


<210> 26726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 26726
ctcttctttt ttttaaaaaa                                                   20


<210> 26727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26727
tgatgtatcc atgatccgca                                                   20


<210> 26728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26728
tattttcgct catgcagatt                                                   20


<210> 26729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26729
tttgattatt ttcgctcatg                                                   20


<210> 26730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26730
cttccatttt gcatttactc                                                   20


<210> 26731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26731
tgcctaaacc atttcaagca                                                   20


<210> 26732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26732
tttgcctaaa ccatttcaag                                                   20


<210> 26733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26733
ctttttgcct aaaccatttc                                                   20


<210> 26734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26734
agttacacag tctccctcca                                                   20


<210> 26735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26735
ctgtcagttg aaaagttaca                                                   20


<210> 26736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26736
catgtttcct gtcagttgaa                                                   20


<210> 26737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26737
cttcatccca tgtttcctgt                                                   20


<210> 26738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26738
gaaagctcaa aggtatcttt                                                   20


<210> 26739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26739
agctgtatga gaaagctcaa                                                   20


<210> 26740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26740
tagctgtatg agaaagctca                                                   20


<210> 26741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26741
tcttacttag ctgtatgaga                                                   20


<210> 26742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26742
ttaatcttac ttagctgtat                                                   20


<210> 26743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26743
ataattgatt taatcttact                                                   20


<210> 26744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26744
atctggtaaa gttttcttac                                                   20


<210> 26745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26745
tcctgaagat tcatctggta                                                   20


<210> 26746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26746
cagcttcctg aagattcatc                                                   20


<210> 26747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26747
ctttacacaa cagcttcctg                                                   20


<210> 26748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26748
ttgtgcgtga ctttacacaa                                                   20


<210> 26749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26749
acattgcatg tagtgatgga                                                   20


<210> 26750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26750
cttaacattg catgtagtga                                                   20


<210> 26751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26751
gttcttctta acattgcatg                                                   20


<210> 26752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26752
tttcatattt ctattgtcat                                                   20


<210> 26753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26753
ttgtgtttca tattaacaat                                                   20


<210> 26754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26754
agtgaataca gcaaagtggt                                                   20


<210> 26755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26755
ggatagtgaa tacagcaaag                                                   20


<210> 26756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26756
ttcggatagt gaatacagca                                                   20


<210> 26757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26757
agtgattcgg atagtgaata                                                   20


<210> 26758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26758
gaacttagca gtgattcgga                                                   20


<210> 26759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 26759
tgaggaactt agcagtgatt                                                   20


<210> 26760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26760
atgaatgctg aggaacttag                                                   20


<210> 26761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26761
aatatgaatg ctgaggaact                                                   20


<210> 26762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26762
tttggaaaat atgaatgctg                                                   20


<210> 26763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26763
atttggaaaa tatgaatgct                                                   20


<210> 26764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26764
tgcacctggg gaatccgatt                                                   20


<210> 26765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26765
gacagtgcca attgcacctg                                                   20


<210> 26766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26766
tgacagtgcc aattgcacct                                                   20


<210> 26767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26767
gtgacagtgc caattgcacc                                                   20


<210> 26768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26768
caatcccagc ctcacagtga                                                   20


<210> 26769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26769
tattcacaat cccagcctca                                                   20


<210> 26770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26770
caatcattta ttcacaatcc                                                   20


<210> 26771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26771
cacttgatgg aagacagtga                                                   20


<210> 26772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26772
gacaaacact tgatggaaga                                                   20


<210> 26773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26773
cgtggacaaa cacttgatgg                                                   20


<210> 26774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26774
cagcgtggac aaacacttga                                                   20


<210> 26775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26775
cagtggtttt ggaagcagcg                                                   20


<210> 26776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26776
aaaatcagtg gttttggaag                                                   20


<210> 26777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26777
gataaaatca gtggttttgg                                                   20


<210> 26778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26778
aaagataaaa tcagtggttt                                                   20


<210> 26779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26779
aaggaaaaag ataaaatcag                                                   20


<210> 26780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26780
ctcaaggaaa aagataaaat                                                   20


<210> 26781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26781
tcacaatttc ctcaaggaaa                                                   20


<210> 26782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26782
caaaggtcac aatttcctca                                                   20


<210> 26783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26783
gcaaaggtca caatttcctc                                                   20


<210> 26784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26784
acacttgctg aaatgagcaa                                                   20


<210> 26785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26785
tacacttgct gaaatgagca                                                   20


<210> 26786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26786
aaccatacac ttgctgaaat                                                   20


<210> 26787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26787
agaagatctg aatactaaga                                                   20


<210> 26788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26788
cagaagatct gaatactaag                                                   20


<210> 26789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26789
aagcagaaga tctgaatact                                                   20


<210> 26790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26790
cagggagata agacaagcag                                                   20


<210> 26791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26791
ttccagggag ataagacaag                                                   20


<210> 26792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26792
gatttccagg gagataagac                                                   20


<210> 26793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26793
ccaaagattt ccagggagat                                                   20


<210> 26794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26794
aaaagccaaa gatttccagg                                                   20


<210> 26795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26795
caaaaagcca aagatttcca                                                   20


<210> 26796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26796
ccaaaaagcc aaagatttcc                                                   20


<210> 26797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26797
tccaaaaagc caaagatttc                                                   20


<210> 26798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26798
aagcattttc caaaaagcca                                                   20


<210> 26799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26799
ttctaaaagc attttccaaa                                                   20


<210> 26800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26800
cttacgtgaa tttattctaa                                                   20


<210> 26801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26801
gcagtgacta gaattaaaaa                                                   20


<210> 26802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26802
tgcagtgact agaattaaaa                                                   20


<210> 26803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26803
ttgcagtgac tagaattaaa                                                   20


<210> 26804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26804
aacctccaga ttgcagtgac                                                   20


<210> 26805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26805
tgcaaacaac ctccagattg                                                   20


<210> 26806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26806
accctgatgc aaacaacctc                                                   20


<210> 26807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26807
caatcttaca gcaattgaag                                                   20


<210> 26808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26808
agacaatctt acagcaattg                                                   20


<210> 26809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26809
atttagttca gacaatctta                                                   20


<210> 26810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26810
attattgagc tcatttagtt                                                   20


<210> 26811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26811
gccttattat tgagctcatt                                                   20


<210> 26812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26812
ctatttctgg ccttattatt                                                   20


<210> 26813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26813
ataggtccta aacctatttc                                                   20


<210> 26814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26814
ccctctcccc accctgatat                                                   20


<210> 26815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26815
cccctctccc caccctgata                                                   20


<210> 26816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26816
attgtggcct atattcggaa                                                   20


<210> 26817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 26817
tttgtattgt ggcctatatt                                                   20


<210> 26818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26818
ttcgttgctg gtttgtattg                                                   20


<210> 26819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26819
ggtgcagaaa tcttcgttgc                                                   20


<210> 26820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26820
tatccgtgtg tgaaaaggtg                                                   20


<210> 26821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26821
ggtcttatcc gtgtgtgaaa                                                   20


<210> 26822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26822
tggtcttatc cgtgtgtgaa                                                   20


<210> 26823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26823
tcgcctctgt ctctctcatg                                                   20


<210> 26824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26824
tctagggata cagtgatgag                                                   20


<210> 26825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26825
agtctaggga tacagtgatg                                                   20


<210> 26826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26826
tagtctaggg atacagtgat                                                   20


<210> 26827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26827
caggggctag tctagggata                                                   20


<210> 26828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26828
agtctgcagg ggctagtcta                                                   20


<210> 26829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26829
gagtctgcag gggctagtct                                                   20


<210> 26830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26830
tgagtctgca ggggctagtc                                                   20


<210> 26831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26831
gctgctgagt ctgcaggggc                                                   20


<210> 26832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26832
ctctgctgct gagtctgcag                                                   20


<210> 26833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26833
cctctgctgc tgagtctgca                                                   20


<210> 26834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26834
ccctctgctg ctgagtctgc                                                   20


<210> 26835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26835
accctctgct gctgagtctg                                                   20


<210> 26836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26836
atggctgacc ctctgctgct                                                   20


<210> 26837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26837
atggtaattc ttcctgggta                                                   20


<210> 26838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26838
tccccatggt aattcttcct                                                   20


<210> 26839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26839
ctccccatgg taattcttcc                                                   20


<210> 26840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26840
atcattctct ctgctcccca                                                   20


<210> 26841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26841
tgatgtaatg ataatggtga                                                   20


<210> 26842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26842
atgatgtaat gataatggtg                                                   20


<210> 26843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26843
aatgatgtaa tgataatggt                                                   20


<210> 26844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26844
tagaaatgat gtaatgataa                                                   20


<210> 26845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26845
tactgctaca gaaatgaact                                                   20


<210> 26846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26846
tgattaaggc actactgcta                                                   20


<210> 26847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26847
cataaaagag aacttgatta                                                   20


<210> 26848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26848
tcataaaaga gaacttgatt                                                   20


<210> 26849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26849
agttttttgg gttcataaaa                                                   20


<210> 26850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26850
agagtttttt gggttcataa                                                   20


<210> 26851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26851
gaatgctagg agagtttttt                                                   20


<210> 26852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26852
tgaatgctag gagagttttt                                                   20


<210> 26853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26853
atgatagatg aatgctagga                                                   20


<210> 26854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26854
taatgataga tgaatgctag                                                   20


<210> 26855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26855
agtaatgata gatgaatgct                                                   20


<210> 26856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26856
gagtaatgat agatgaatgc                                                   20


<210> 26857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26857
caggtaataa agagtaatga                                                   20


<210> 26858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26858
tgtttctcac aggtaataaa                                                   20


<210> 26859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26859
cctgtttctc acaggtaata                                                   20


<210> 26860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26860
ttgttctacc tgtttctcac                                                   20


<210> 26861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26861
tttgttctac ctgtttctca                                                   20


<210> 26862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26862
atctttagca caatagaaaa                                                   20


<210> 26863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26863
aacaaagatc tttagcacaa                                                   20


<210> 26864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26864
gtaaagtgaa caaagatctt                                                   20


<210> 26865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26865
atcttctggt aaagtgaaca                                                   20


<210> 26866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26866
gtgacattta tcttctggta                                                   20


<210> 26867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26867
aacaagtgac atttatcttc                                                   20


<210> 26868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26868
tgtgttccat ttgttagaac                                                   20


<210> 26869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26869
gtattatgtg ttccatttgt                                                   20


<210> 26870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26870
ttttattaca ggaactttgt                                                   20


<210> 26871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26871
tggacagaat attttattac                                                   20


<210> 26872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26872
ttggacagaa tattttatta                                                   20


<210> 26873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26873
attctagcac gcttcttgga                                                   20


<210> 26874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26874
cagtattcta gcacgcttct                                                   20


<210> 26875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26875
agtcacatta agcagtattc                                                   20


<210> 26876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26876
gctttaaaag tcacattaag                                                   20


<210> 26877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26877
tgtgctttaa aagtcacatt                                                   20


<210> 26878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26878
ggtccttttc tgtgctttaa                                                   20


<210> 26879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26879
gtgaatcagg ttcaaggggc                                                   20


<210> 26880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26880
tgtgaatcag gttcaagggg                                                   20


<210> 26881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26881
gcatgtgaat caggttcaag                                                   20


<210> 26882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26882
tgcatgtgaa tcaggttcaa                                                   20


<210> 26883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26883
ttgcatgtga atcaggttca                                                   20


<210> 26884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26884
attgcatgtg aatcaggttc                                                   20


<210> 26885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26885
gccattattg catgtgaatc                                                   20


<210> 26886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26886
tgccattatt gcatgtgaat                                                   20


<210> 26887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26887
aacataatag gcaatgaagc                                                   20


<210> 26888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26888
ggcaaacata ataggcaatg                                                   20


<210> 26889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26889
tcttctaggg caaacataat                                                   20


<210> 26890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26890
ctcttctagg gcaaacataa                                                   20


<210> 26891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26891
cttttttgta atctcttcta                                                   20


<210> 26892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26892
ccttttttgt aatctcttct                                                   20


<210> 26893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26893
accttttttg taatctcttc                                                   20


<210> 26894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26894
aaaactttgc ttcaagagaa                                                   20


<210> 26895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26895
gaaataaaac tttgcttcaa                                                   20


<210> 26896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26896
cagaaataaa actttgcttc                                                   20


<210> 26897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26897
agaaaaaaaa ataattaact                                                   20


<210> 26898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26898
acctgcactt ctacttcagt                                                   20


<210> 26899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26899
gttgacctgc acttctactt                                                   20


<210> 26900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26900
tttttttttt ttacaatgtg                                                   20


<210> 26901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26901
catttttttt ttttacaatg                                                   20


<210> 26902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26902
caatttcctt ttttgtttcc                                                   20


<210> 26903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26903
tagatgattt gggccatgaa                                                   20


<210> 26904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26904
aaacatgagg tagatgattt                                                   20


<210> 26905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26905
aaaacatgag gtagatgatt                                                   20


<210> 26906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26906
tcgattttta aaacatgagg                                                   20


<210> 26907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26907
acttcgattt ttaaaacatg                                                   20


<210> 26908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26908
tacttcgatt tttaaaacat                                                   20


<210> 26909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26909
tgagtacctt ctcttcagtt                                                   20


<210> 26910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26910
atgagtacct tctcttcagt                                                   20


<210> 26911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26911
agggatgagt accttctctt                                                   20


<210> 26912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26912
gtatgaccaa aatgagggat                                                   20


<210> 26913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26913
tttaggtatg accaaaatga                                                   20


<210> 26914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26914
ttttaggtat gaccaaaatg                                                   20


<210> 26915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26915
gttttaggta tgaccaaaat                                                   20


<210> 26916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26916
catctcagag aaattgtttt                                                   20


<210> 26917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26917
acatctcaga gaaattgttt                                                   20


<210> 26918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26918
ctgtctttac ttacatctca                                                   20


<210> 26919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26919
tgctgtcttt acttacatct                                                   20


<210> 26920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26920
cttattgaga cacacaattt                                                   20


<210> 26921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26921
tctcctaaat cagacttatt                                                   20


<210> 26922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26922
tccagaattt tctcctaaat                                                   20


<210> 26923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26923
attcccagac ctccgacctc                                                   20


<210> 26924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26924
aaattgttca ctatgattcc                                                   20


<210> 26925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26925
taaaccattt cagggatttt                                                   20


<210> 26926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26926
acaactatta aaccatttca                                                   20


<210> 26927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26927
gacaactatt aaaccatttc                                                   20


<210> 26928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26928
tgacaactat taaaccattt                                                   20


<210> 26929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26929
atacacaaac atgtatttca                                                   20


<210> 26930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26930
aaagcagtaa aatggaccct                                                   20


<210> 26931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26931
aggagactaa agcagtaaaa                                                   20


<210> 26932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26932
acagattaag gagactaaag                                                   20


<210> 26933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26933
tgaacagatt aaggagacta                                                   20


<210> 26934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26934
taacgcttga acagattaag                                                   20


<210> 26935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26935
tttaacgctt gaacagatta                                                   20


<210> 26936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26936
gtttaacgct tgaacagatt                                                   20


<210> 26937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26937
aaaatggttt aacgcttgaa                                                   20


<210> 26938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26938
gccactgcac cctgttaaaa                                                   20


<210> 26939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26939
caacgaagtg agaaccgcat                                                   20


<210> 26940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26940
gcagctgttc tcaacgaagt                                                   20


<210> 26941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26941
cacagcagct gttctcaacg                                                   20


<210> 26942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26942
aggaaagaaa gttgtcacag                                                   20


<210> 26943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26943
tgaaggaaag aaagttgtca                                                   20


<210> 26944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26944
tatgattttt gaaggaaaga                                                   20


<210> 26945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26945
gacttatgat ttttgaagga                                                   20


<210> 26946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26946
tagagactta tgatttttga                                                   20


<210> 26947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26947
ttagagactt atgatttttg                                                   20


<210> 26948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26948
actaggttat agaaatatta                                                   20


<210> 26949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26949
ccactaggtt atagaaatat                                                   20


<210> 26950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26950
ttgtgatacc cactaggtta                                                   20


<210> 26951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26951
tttgatttgt gatacccact                                                   20


<210> 26952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26952
ttttgatttg tgatacccac                                                   20


<210> 26953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26953
taatacaaag atgatacaaa                                                   20


<210> 26954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26954
ttgtttaaca tgataataca                                                   20


<210> 26955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26955
tcaaaatgag actttgaatc                                                   20


<210> 26956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26956
cgaagaccat taatcaaaat                                                   20


<210> 26957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26957
tctatatcag gaaacttgcg                                                   20


<210> 26958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26958
agtcagctcg ggtctatatc                                                   20


<210> 26959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26959
tagtcagctc gggtctatat                                                   20


<210> 26960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26960
aaataagttt tagtcagctc                                                   20


<210> 26961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 26961
aaaataagtt ttagtcagct                                                   20


<210> 26962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26962
ttggaaaaat aagttttagt                                                   20


<210> 26963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26963
acatttggaa aaataagttt                                                   20


<210> 26964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26964
aggaaaacat ttggaaaaat                                                   20


<210> 26965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26965
cataggttta ggaaaacatt                                                   20


<210> 26966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26966
tggttaagga ccataggttt                                                   20


<210> 26967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26967
atggttaagg accataggtt                                                   20


<210> 26968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26968
ttgaaatggt taaggaccat                                                   20


<210> 26969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26969
attgaaatgg ttaaggacca                                                   20


<210> 26970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26970
ccagttaatt gaaatggtta                                                   20


<210> 26971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26971
gccagttaat tgaaatggtt                                                   20


<210> 26972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26972
ttattgccag ttaattgaaa                                                   20


<210> 26973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26973
tcttttgatc attttattgc                                                   20


<210> 26974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26974
attagagtta tatgctaaac                                                   20


<210> 26975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26975
tgatatagcc ttccacatta                                                   20


<210> 26976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26976
cctgatatag ccttccacat                                                   20


<210> 26977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26977
aaaaaaatat attcctgata                                                   20


<210> 26978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26978
tatcatagaa ttaaaattta                                                   20


<210> 26979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26979
atatcataga attaaaattt                                                   20


<210> 26980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26980
tggaggaact accaatatca                                                   20


<210> 26981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26981
aaccaactct tgactaatgg                                                   20


<210> 26982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26982
taaccaactc ttgactaatg                                                   20


<210> 26983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26983
gataaccaac tcttgactaa                                                   20


<210> 26984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26984
tatacagaag aaaattcata                                                   20


<210> 26985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26985
ttggcaaaga aagtatacag                                                   20


<210> 26986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26986
ttcttggcaa agaaagtata                                                   20


<210> 26987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26987
ttattaattc ttggcaaaga                                                   20


<210> 26988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 26988
ttaattatta attcttggca                                                   20


<210> 26989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26989
attctttaat tattaattct                                                   20


<210> 26990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26990
gtgtttcatt cgtgtagaat                                                   20


<210> 26991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26991
tggtgagtgt ttcattcgtg                                                   20


<210> 26992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26992
aacagagggg atatattggt                                                   20


<210> 26993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 26993
aaaaaacaga ggggatatat                                                   20


<210> 26994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26994
atttatagta aaaaacagag                                                   20


<210> 26995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 26995
gatttatagt aaaaaacaga                                                   20


<210> 26996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 26996
agatttatag taaaaaacag                                                   20


<210> 26997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 26997
tagatttata gtaaaaaaca                                                   20


<210> 26998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 26998
tatagattta tagtaaaaaa                                                   20


<210> 26999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 26999
tgaaaggcaa tatagattta                                                   20


<210> 27000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27000
ttttcctttg aaaggcaata                                                   20


<210> 27001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27001
gagttatgtt ttcctttgaa                                                   20


<210> 27002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27002
agagttatgt tttcctttga                                                   20


<210> 27003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27003
gatcatggac actggtgtga                                                   20


<210> 27004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27004
ttgatcatgg acactggtgt                                                   20


<210> 27005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27005
taatatttga tcatggacac                                                   20


<210> 27006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27006
gataatataa tatttgatca                                                   20


<210> 27007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27007
tgaagtgggc ctttgaacaa                                                   20


<210> 27008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27008
ttaagggagg tttttgaagt                                                   20


<210> 27009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27009
cttaagggag gtttttgaag                                                   20


<210> 27010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27010
agacttaagg gaggtttttg                                                   20


<210> 27011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27011
tctagattga gacttaaggg                                                   20


<210> 27012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27012
ttctagattg agacttaagg                                                   20


<210> 27013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27013
agttctagat tgagacttaa                                                   20


<210> 27014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27014
gagttctaga ttgagactta                                                   20


<210> 27015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27015
agagttctag attgagactt                                                   20


<210> 27016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27016
taaagaaaga gttctagatt                                                   20


<210> 27017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27017
gacacttaaa gaaagagttc                                                   20


<210> 27018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27018
gcttctgaca cttaaagaaa                                                   20


<210> 27019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27019
atgcttctga cacttaaaga                                                   20


<210> 27020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27020
taaaatgctt ctgacactta                                                   20


<210> 27021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27021
agtgatgagt tctaccaata                                                   20


<210> 27022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27022
aagtgatgag ttctaccaat                                                   20


<210> 27023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27023
tcagacaagg aagaagtgat                                                   20


<210> 27024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27024
aaagttatca gacaaggaag                                                   20


<210> 27025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27025
acaaaagtta tcagacaagg                                                   20


<210> 27026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27026
aacacaaaag ttatcagaca                                                   20


<210> 27027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27027
gaacacaaaa gttatcagac                                                   20


<210> 27028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27028
aagtggaaca caaaagttat                                                   20


<210> 27029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27029
cacagaaaag tggaacacaa                                                   20


<210> 27030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27030
cttattaggg cacagaaaag                                                   20


<210> 27031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27031
atgcttatta gggcacagaa                                                   20


<210> 27032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27032
ttaagatgct tattagggca                                                   20


<210> 27033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27033
tgtttttaag atgcttatta                                                   20


<210> 27034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27034
ttgtttttaa gatgcttatt                                                   20


<210> 27035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27035
cttgttttta agatgcttat                                                   20


<210> 27036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27036
atggtctaat ccttgttttt                                                   20


<210> 27037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27037
agaccaaaac caattaccca                                                   20


<210> 27038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27038
ttaggtatta tttagggtgg                                                   20


<210> 27039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27039
tgtttaggta ttatttaggg                                                   20


<210> 27040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27040
cattgtttag gtattattta                                                   20


<210> 27041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27041
gcattgttta ggtattattt                                                   20


<210> 27042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27042
ggcattgttt aggtattatt                                                   20


<210> 27043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27043
tagataggaa ggcattgttt                                                   20


<210> 27044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27044
ttagatagga aggcattgtt                                                   20


<210> 27045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27045
taggtattgt ttagatagga                                                   20


<210> 27046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27046
ttaggtattg tttagatagg                                                   20


<210> 27047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27047
tatttaggta ttgtttagat                                                   20


<210> 27048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27048
gtatttaggt attgtttaga                                                   20


<210> 27049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27049
aaaggtattt aggtattgtt                                                   20


<210> 27050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27050
ctgtgaaaag aaaggtattt                                                   20


<210> 27051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27051
tctgtgaaaa gaaaggtatt                                                   20


<210> 27052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27052
tatcttctct gtgaaaagaa                                                   20


<210> 27053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27053
gtatcttctc tgtgaaaaga                                                   20


<210> 27054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27054
tttagtatct tctctgtgaa                                                   20


<210> 27055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27055
attttccact caatattttt                                                   20


<210> 27056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27056
caaagggaaa ggcattccct                                                   20


<210> 27057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27057
tcaggcaaat tcaaagggaa                                                   20


<210> 27058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27058
ttcaggcaaa ttcaaaggga                                                   20


<210> 27059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27059
tttattcagg caaattcaaa                                                   20


<210> 27060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27060
atttattcag gcaaattcaa                                                   20


<210> 27061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27061
tatttattca ggcaaattca                                                   20


<210> 27062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27062
taaatgttta ttatttattc                                                   20


<210> 27063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27063
ttaaatgttt attatttatt                                                   20


<210> 27064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27064
tgtgaaaaca tgccacatca                                                   20


<210> 27065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27065
taaaatcgtg aaattgggaa                                                   20


<210> 27066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27066
ataaaatcgt gaaattggga                                                   20


<210> 27067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27067
tgacataaaa tcgtgaaatt                                                   20


<210> 27068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27068
ttgacataaa atcgtgaaat                                                   20


<210> 27069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27069
caggcgtgag ctactgcgcc                                                   20


<210> 27070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27070
agtgctagaa ttacaggcgt                                                   20


<210> 27071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27071
tcccaaagtg ctagaattac                                                   20


<210> 27072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27072
ctcccaaagt gctagaatta                                                   20


<210> 27073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27073
tccgtcgcct cccaaagtgc                                                   20


<210> 27074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27074
ccagcctccg tcgcctccca                                                   20


<210> 27075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27075
actcctgacc tcaggtgatc                                                   20


<210> 27076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27076
ggtctcgaac tcctgacctc                                                   20


<210> 27077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27077
tggtctcgaa ctcctgacct                                                   20


<210> 27078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27078
tttcgtcatg ttggccaggc                                                   20


<210> 27079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27079
aggttttcgt catgttggcc                                                   20


<210> 27080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27080
caggttttcg tcatgttggc                                                   20


<210> 27081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27081
gagacaggtt ttcgtcatgt                                                   20


<210> 27082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27082
tttgtatttt tagtagagac                                                   20


<210> 27083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27083
ttttgtattt ttagtagaga                                                   20


<210> 27084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27084
taatttttgt atttttagta                                                   20


<210> 27085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27085
gctaattttt gtatttttag                                                   20


<210> 27086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27086
ccagctaatt tttgtatttt                                                   20


<210> 27087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27087
acaggtgcat gctaccgtgc                                                   20


<210> 27088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27088
tcctgagtag ctgagattac                                                   20


<210> 27089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27089
ctcctgagta gctgagatta                                                   20


<210> 27090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27090
cctcagcctc ctgagtagct                                                   20


<210> 27091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27091
ttctgcctca gcctcctgag                                                   20


<210> 27092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27092
ttcttctgcc tcagcctcct                                                   20


<210> 27093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27093
ttcaagcaat tcttctgcct                                                   20


<210> 27094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27094
aacctccacc tcccaggttc                                                   20


<210> 27095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27095
caccccaacc tccacctccc                                                   20


<210> 27096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27096
tcaccccaac ctccacctcc                                                   20


<210> 27097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 27097
ggagtgcaat gatgtgatct                                                   20


<210> 27098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27098
tcgctttgtt gcccaggctg                                                   20


<210> 27099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27099
tctcgctttg ttgcccaggc                                                   20


<210> 27100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27100
ggaatctcgc tttgttgccc                                                   20


<210> 27101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27101
tggaatctcg ctttgttgcc                                                   20


<210> 27102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27102
tatttttttt ttttttgaga                                                   20


<210> 27103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27103
tgtgtatttt tttttttttt                                                   20


<210> 27104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27104
tatttataag ctcctatagc                                                   20


<210> 27105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27105
gtatttataa gctcctatag                                                   20


<210> 27106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27106
tttgtattta taagctccta                                                   20


<210> 27107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27107
cttctctgtt ttgtatttat                                                   20


<210> 27108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27108
cttacaaatt ccttccaata                                                   20


<210> 27109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27109
ataagcttcc tagttttata                                                   20


<210> 27110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27110
gtagtaataa ataagcttcc                                                   20


<210> 27111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27111
ctcaagttgt agtaataaat                                                   20


<210> 27112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27112
tgttgatcac cctcaagttg                                                   20


<210> 27113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27113
tataattgtt gatcaccctc                                                   20


<210> 27114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27114
tgcacaaaaa atatacatcc                                                   20


<210> 27115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27115
catttatgca gcacaaattc                                                   20


<210> 27116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27116
catacacaaa ggcatttatg                                                   20


<210> 27117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27117
actgtgccag acatacacaa                                                   20


<210> 27118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27118
tactgtgcca gacatacaca                                                   20


<210> 27119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27119
cacactaaat gatactgtgc                                                   20


<210> 27120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27120
gacagaaact tacattcatc                                                   20


<210> 27121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27121
agaggattca gaagtcagga                                                   20


<210> 27122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27122
aaaaagagga ttcagaagtc                                                   20


<210> 27123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27123
taaaaagagg attcagaagt                                                   20


<210> 27124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27124
accataaaaa gaggattcag                                                   20


<210> 27125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27125
accaccataa aaagaggatt                                                   20


<210> 27126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27126
cttgtaacca ccataaaaag                                                   20


<210> 27127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27127
ccttgtaacc accataaaaa                                                   20


<210> 27128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27128
gtccttgtaa ccaccataaa                                                   20


<210> 27129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27129
aagtgccttc acttcccact                                                   20


<210> 27130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27130
tatggtaaca gccatatggt                                                   20


<210> 27131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27131
gggatatggt aacagccata                                                   20


<210> 27132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27132
cagaaggtgg gatatggtaa                                                   20


<210> 27133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27133
ggtatccaga aggtgggata                                                   20


<210> 27134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27134
tcatcaggta tccagaaggt                                                   20


<210> 27135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27135
ctcatcaggt atccagaagg                                                   20


<210> 27136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27136
tctctcatca ggtatccaga                                                   20


<210> 27137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27137
atctctcatc aggtatccag                                                   20


<210> 27138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27138
caaatctctc atcaggtatc                                                   20


<210> 27139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27139
ttgacatcaa atctctcatc                                                   20


<210> 27140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27140
cttgacatca aatctctcat                                                   20


<210> 27141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27141
gttgacttgt cacagttggt                                                   20


<210> 27142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27142
ccacgttgac ttgtcacagt                                                   20


<210> 27143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27143
tctgccacgt tgacttgtca                                                   20


<210> 27144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27144
gggataaaat gctcttctat                                                   20


<210> 27145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27145
cttacaagca ggagaaaatt                                                   20


<210> 27146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27146
gcttacaagc aggagaaaat                                                   20


<210> 27147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27147
actttcaagc ttacaagcag                                                   20


<210> 27148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27148
aaactttcaa gcttacaagc                                                   20


<210> 27149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27149
aaaactttca agcttacaag                                                   20


<210> 27150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27150
gtgaaaactt tcaagcttac                                                   20


<210> 27151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27151
actgattagt gaaaactttc                                                   20


<210> 27152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27152
tttttcttcc ttatactgat                                                   20


<210> 27153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27153
tttttgaatt agtgttttct                                                   20


<210> 27154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27154
aatctgccta ctttttgaat                                                   20


<210> 27155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27155
cctatagcat cgcgtggaca                                                   20


<210> 27156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27156
cactggccta tagcatcgcg                                                   20


<210> 27157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27157
gttttccagc cactggccta                                                   20


<210> 27158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27158
cgaaaaagtt ttccagccac                                                   20


<210> 27159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27159
ccctttacga aaaagttttc                                                   20


<210> 27160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27160
tcatttggcc ctttacgaaa                                                   20


<210> 27161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27161
agtctaaaat atttatcatt                                                   20


<210> 27162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27162
tagaaatcgt atgcccaata                                                   20


<210> 27163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27163
gcagaggtga atagctgcca                                                   20


<210> 27164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27164
attacagtgg cagaggtgaa                                                   20


<210> 27165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27165
cttttacatt acagtggcag                                                   20


<210> 27166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27166
gcttttacat tacagtggca                                                   20


<210> 27167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27167
ctgcttttac attacagtgg                                                   20


<210> 27168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27168
tgactgcttt tacattacag                                                   20


<210> 27169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27169
ctatgactgc ttttacatta                                                   20


<210> 27170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27170
cataaacttt attcaaacat                                                   20


<210> 27171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27171
tcataaactt tattcaaaca                                                   20


<210> 27172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27172
attatatgaa atgcaaattt                                                   20


<210> 27173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27173
gtggttaaaa taatcaaaag                                                   20


<210> 27174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27174
taagtggtta aaataatcaa                                                   20


<210> 27175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27175
atgattttta catttttaag                                                   20


<210> 27176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27176
agaatgattt ttacattttt                                                   20


<210> 27177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27177
attgtgtggc cctgggagct                                                   20


<210> 27178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27178
ctgttattgt gtggccctgg                                                   20


<210> 27179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27179
gcctgttatt gtgtggccct                                                   20


<210> 27180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27180
tgcctgttat tgtgtggccc                                                   20


<210> 27181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27181
gtccaatgcc tgttattgtg                                                   20


<210> 27182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27182
tatgccccac agaccaaagc                                                   20


<210> 27183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27183
cacctatgcc ccacagacca                                                   20


<210> 27184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27184
ggatcagcac ctatgcccca                                                   20


<210> 27185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27185
ctagcctcta tagcaaggat                                                   20


<210> 27186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27186
taagactagc ctctatagca                                                   20


<210> 27187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27187
gtaagactag cctctatagc                                                   20


<210> 27188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27188
atgtgtaaga ctagcctcta                                                   20


<210> 27189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27189
cttatagcca tgtgtaagac                                                   20


<210> 27190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27190
cgcaccttat agccatgtgt                                                   20


<210> 27191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27191
aggactggtc ccgcacctta                                                   20


<210> 27192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27192
accaaggcaa atgaaaggac                                                   20


<210> 27193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27193
aatggaccaa ggcaaatgaa                                                   20


<210> 27194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27194
taatggacca aggcaaatga                                                   20


<210> 27195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27195
atgaagttaa taatggacca                                                   20


<210> 27196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27196
aatgaagtta ataatggacc                                                   20


<210> 27197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27197
aacaaaaatg aagttaataa                                                   20


<210> 27198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27198
agttaataat aacaaaaatg                                                   20


<210> 27199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27199
ctagtaaata aaatataatt                                                   20


<210> 27200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27200
atgctctctt gaagctatac                                                   20


<210> 27201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27201
tgatggcata tgctctcttg                                                   20


<210> 27202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27202
ttctctaatt ttgaaagtga                                                   20


<210> 27203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27203
atctttttct ctaattttga                                                   20


<210> 27204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27204
gcctattcat tttaaggcaa                                                   20


<210> 27205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27205
tgcctattca ttttaaggca                                                   20


<210> 27206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27206
atcactgcct attcatttta                                                   20


<210> 27207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27207
aatcactgcc tattcatttt                                                   20


<210> 27208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27208
aaattttgta ttagttttcc                                                   20


<210> 27209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27209
aagagaacga aattttgtat                                                   20


<210> 27210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27210
atacaagaaa gaacaggaaa                                                   20


<210> 27211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27211
taatacaaga aagaacagga                                                   20


<210> 27212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27212
attttaatac aagaaagaac                                                   20


<210> 27213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27213
aattttaata caagaaagaa                                                   20


<210> 27214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27214
gtgataattt taatacaaga                                                   20


<210> 27215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27215
aatagtgata attttaatac                                                   20


<210> 27216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27216
aattattaat tgcaaaagaa                                                   20


<210> 27217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27217
tctacaatta ttaattgcaa                                                   20


<210> 27218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27218
catgcatttt aatttctctg                                                   20


<210> 27219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27219
gaaacctggt ggtatgtaac                                                   20


<210> 27220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27220
catggtcatt ggaaacctgg                                                   20


<210> 27221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27221
ggtcatggtc attggaaacc                                                   20


<210> 27222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27222
tacatgatgg tcatggtcat                                                   20


<210> 27223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27223
tattgtttac atgatggtca                                                   20


<210> 27224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27224
gtgccttatt gtttacatga                                                   20


<210> 27225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27225
ctgtatggag gtcgctggtc                                                   20


<210> 27226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27226
tgggactgta tggaggtcgc                                                   20


<210> 27227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27227
gaccatgtgg gactgtatgg                                                   20


<210> 27228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27228
agaccatgtg ggactgtatg                                                   20


<210> 27229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27229
agagaccatg tgggactgta                                                   20


<210> 27230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27230
agagtggata gagaccatgt                                                   20


<210> 27231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27231
gagagtggat agagaccatg                                                   20


<210> 27232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27232
tgctgtgtgg agagtggata                                                   20


<210> 27233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27233
cgtgctgtgt ggagagtgga                                                   20


<210> 27234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27234
tccgcgtgct gtgtggagag                                                   20


<210> 27235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27235
tgttccgcgt gctgtgtgga                                                   20


<210> 27236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27236
tgtgttccgc gtgctgtgtg                                                   20


<210> 27237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27237
attgtgttcc gcgtgctgtg                                                   20


<210> 27238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27238
atgactgtac gctcccacgg                                                   20


<210> 27239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 27239
atgatgactg tacgctccca                                                   20


<210> 27240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27240
gctacaaaga atgtgtctgc                                                   20


<210> 27241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27241
gctctttggt aagagctaca                                                   20


<210> 27242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27242
ggcatgcagc tctttggtaa                                                   20


<210> 27243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27243
tcggcatgca gctctttggt                                                   20


<210> 27244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27244
gtggtcggca tgcagctctt                                                   20


<210> 27245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27245
tttttgctgt ggtcggcatg                                                   20


<210> 27246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 27246
gtcttcattt ttgctgtggt                                                   20


<210> 27247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27247
catcgtcttc atttttgctg                                                   20


<210> 27248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27248
aggtaacctc accttagtgt                                                   20


<210> 27249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27249
ggctctaggt aacctcacct                                                   20


<210> 27250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27250
ggtaactcag taggggctct                                                   20


<210> 27251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27251
tggtaactca gtaggggctc                                                   20


<210> 27252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27252
gatcattggt aactcagtag                                                   20


<210> 27253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27253
agatcattgg taactcagta                                                   20


<210> 27254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27254
aagatcattg gtaactcagt                                                   20


<210> 27255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27255
taagatcatt ggtaactcag                                                   20


<210> 27256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27256
gattaagatc attggtaact                                                   20


<210> 27257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27257
aacatgctga ttaagatcat                                                   20


<210> 27258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27258
caacattgaa catgctgatt                                                   20


<210> 27259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27259
tcttcaagtt ggcaaaatcc                                                   20


<210> 27260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27260
ttagctccga gtcttcaagt                                                   20


<210> 27261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27261
gcttttagct ccgagtcttc                                                   20


<210> 27262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27262
ttatatttgc ttttagctcc                                                   20


<210> 27263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27263
ttaaacttta tatttgcttt                                                   20


<210> 27264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27264
aaacattgaa aagattttca                                                   20


<210> 27265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27265
tcaagattgg aaacattgaa                                                   20


<210> 27266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27266
ctttgaacaa aaatcaagat                                                   20


<210> 27267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27267
ttaccctttg aacaaaaatc                                                   20


<210> 27268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27268
tgacaatatt ataggactta                                                   20


<210> 27269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27269
gataataatg acaatattat                                                   20


<210> 27270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27270
ggataataat gacaatatta                                                   20


<210> 27271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27271
aaaaataaga atattttagc                                                   20


<210> 27272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27272
aatgaaaaat aagaatattt                                                   20


<210> 27273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27273
aattgatgaa aatgaaaaat                                                   20


<210> 27274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27274
gcaagtggaa caaaataaca                                                   20


<210> 27275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27275
tggcaagtgg aacaaaataa                                                   20


<210> 27276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27276
ttgtaatttt ttgtggcaag                                                   20


<210> 27277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27277
gtgttgtaat tttttgtggc                                                   20


<210> 27278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27278
atatgtgttg taattttttg                                                   20


<210> 27279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27279
aatcctgaac taaaagtaca                                                   20


<210> 27280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27280
ctatagcaat cctgaactaa                                                   20


<210> 27281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27281
attatgataa gaggtttcta                                                   20


<210> 27282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27282
atatcacaaa ttatgataag                                                   20


<210> 27283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27283
aatatcacaa attatgataa                                                   20


<210> 27284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27284
aaaatatcac aaattatgat                                                   20


<210> 27285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27285
ggataaatta tcaattctaa                                                   20


<210> 27286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27286
agtattagaa agtagaatta                                                   20


<210> 27287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27287
aagtattaga aagtagaatt                                                   20


<210> 27288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27288
tgtatgaaag tattagaaag                                                   20


<210> 27289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27289
aaatgtatga aagtattaga                                                   20


<210> 27290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27290
gagaaaatgt atgaaagtat                                                   20


<210> 27291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27291
cggcatgaga aaatgtatga                                                   20


<210> 27292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27292
ttttatctaa gtgtcggcat                                                   20


<210> 27293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 27293
gctagatttt atctaagtgt                                                   20


<210> 27294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27294
taatatgcta gattttatct                                                   20


<210> 27295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27295
agcacattcc tctaatatgc                                                   20


<210> 27296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27296
aaacaaataa agacttttta                                                   20


<210> 27297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27297
taacaatata aaaacaaata                                                   20


<210> 27298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27298
ctttatgaat ttggtaatta                                                   20


<210> 27299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27299
tgttcataac tttatgaatt                                                   20


<210> 27300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27300
agtaagaagc ttgtggctta                                                   20


<210> 27301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27301
atttcagagt aagaagcttg                                                   20


<210> 27302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27302
ataatttatt tcagagtaag                                                   20


<210> 27303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27303
acaataattt atttcagagt                                                   20


<210> 27304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27304
tagtacaata atttatttca                                                   20


<210> 27305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27305
tatagtacaa taatttattt                                                   20


<210> 27306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27306
ataaatattt tctattaata                                                   20


<210> 27307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27307
acatgctcaa ttctaatttg                                                   20


<210> 27308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27308
gaatattttt acaatttttg                                                   20


<210> 27309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27309
ttcattgaca aatgcactta                                                   20


<210> 27310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27310
caagattata tcttgatatc                                                   20


<210> 27311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27311
gggaatttga atcaaaaggc                                                   20


<210> 27312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27312
ttttgggaat ttgaatcaaa                                                   20


<210> 27313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27313
cttttgggaa tttgaatcaa                                                   20


<210> 27314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27314
cattattttt aaaaactttt                                                   20


<210> 27315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27315
gcattatttt taaaaacttt                                                   20


<210> 27316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27316
ataataaagg ggtatttctt                                                   20


<210> 27317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27317
cattatattc tataataaag                                                   20


<210> 27318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27318
ccattatatt ctataataaa                                                   20


<210> 27319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27319
gccattatat tctataataa                                                   20


<210> 27320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27320
tgccattata ttctataata                                                   20


<210> 27321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27321
agactggtaa acataaacta                                                   20


<210> 27322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27322
cagactggta aacataaact                                                   20


<210> 27323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27323
agttctgcga tcattcagac                                                   20


<210> 27324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27324
ttgtcagttc tgcgatcatt                                                   20


<210> 27325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27325
agcagatgtg gaaggattgt                                                   20


<210> 27326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27326
ctctttctag cagatgtgga                                                   20


<210> 27327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27327
gctctttcta gcagatgtgg                                                   20


<210> 27328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27328
ggagctcttt ctagcagatg                                                   20


<210> 27329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27329
tttagtggag ctctttctag                                                   20


<210> 27330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27330
aagtttagtg gagctctttc                                                   20


<210> 27331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27331
ttgtgacttt aagtttagtg                                                   20


<210> 27332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27332
tattgtgact ttaagtttag                                                   20


<210> 27333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27333
ccttattgtg actttaagtt                                                   20


<210> 27334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27334
gacagcctta ttgtgacttt                                                   20


<210> 27335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27335
gtaggctgga atatttttga                                                   20


<210> 27336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27336
atgagtattt ccaagtaggc                                                   20


<210> 27337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27337
ccatatgagt atttccaagt                                                   20


<210> 27338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27338
tccatatgag tatttccaag                                                   20


<210> 27339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27339
ggatccatat gagtatttcc                                                   20


<210> 27340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27340
tgattgccat ggatccatat                                                   20


<210> 27341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27341
ggtattaaaa ctgattgcca                                                   20


<210> 27342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27342
tggaatcttt gcagctgaaa                                                   20


<210> 27343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27343
ggtctttact ggaatctttg                                                   20


<210> 27344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27344
tttctcactt aggtctttac                                                   20


<210> 27345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27345
aaacattatt tttctcactt                                                   20


<210> 27346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27346
aaaacattat ttttctcact                                                   20


<210> 27347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27347
ttcctgtttt ctaatattaa                                                   20


<210> 27348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27348
cacagtaaat gctaagcaaa                                                   20


<210> 27349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27349
tctggaacac agtaaatgct                                                   20


<210> 27350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27350
ttagcaaact gtctggaaca                                                   20


<210> 27351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27351
aaagtattta gcaaactgtc                                                   20


<210> 27352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27352
atatccattt ataaagtatt                                                   20


<210> 27353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27353
gataagaata tccatttata                                                   20


<210> 27354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27354
tttacaggac taagttagat                                                   20


<210> 27355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27355
cctaatttac aggactaagt                                                   20


<210> 27356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27356
aatacctaat ttacaggact                                                   20


<210> 27357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27357
aagagcaata cctaatttac                                                   20


<210> 27358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27358
gaagagcaat acctaattta                                                   20


<210> 27359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27359
ctgatatggg agccagggaa                                                   20


<210> 27360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27360
tgctgatatg ggagccaggg                                                   20


<210> 27361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27361
tgatgctgat atgggagcca                                                   20


<210> 27362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27362
ttgatgctga tatgggagcc                                                   20


<210> 27363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27363
tttgatgctg atatgggagc                                                   20


<210> 27364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27364
accttttgat gctgatatgg                                                   20


<210> 27365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27365
caaccttttg atgctgatat                                                   20


<210> 27366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27366
tcaacctttt gatgctgata                                                   20


<210> 27367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27367
gagcactgac aggacagtta                                                   20


<210> 27368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27368
atgagcactg acaggacagt                                                   20


<210> 27369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27369
aatgatgagc actgacagga                                                   20


<210> 27370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27370
taaaaatgat gagcactgac                                                   20


<210> 27371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27371
ctaaaaatga tgagcactga                                                   20


<210> 27372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27372
aaatgctgtc taaaaatgat                                                   20


<210> 27373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27373
ccacataaat tctttgaaaa                                                   20


<210> 27374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27374
gttttctttt tatcttcttc                                                   20


<210> 27375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27375
aaaagactgg ctcaaaattt                                                   20


<210> 27376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27376
cagatcagaa aaaaaaagac                                                   20


<210> 27377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27377
gtagtcagat cagaaaaaaa                                                   20


<210> 27378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27378
tactctaaca gtagtcagat                                                   20


<210> 27379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27379
tttattactc taacagtagt                                                   20


<210> 27380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27380
gttctttatt actctaacag                                                   20


<210> 27381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27381
catgttcttt attactctaa                                                   20


<210> 27382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27382
ctgataaatc tttaaagagt                                                   20


<210> 27383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27383
tctgctgata aatctttaaa                                                   20


<210> 27384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27384
cttctgctga taaatcttta                                                   20


<210> 27385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27385
aagctttaga agtattactt                                                   20


<210> 27386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27386
cttttgtgtc aaagctttag                                                   20


<210> 27387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27387
gcacttttgt gtcaaagctt                                                   20


<210> 27388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27388
tgcaatgcac ttttgtgtca                                                   20


<210> 27389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27389
ttaagtgagt cctttgatac                                                   20


<210> 27390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27390
tcggtgttgc ctttttaagt                                                   20


<210> 27391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27391
catttcggtg ttgccttttt                                                   20


<210> 27392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 27392
tgtacccaaa ggattcattt                                                   20


<210> 27393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27393
ttgagtcaaa gtgtacccaa                                                   20


<210> 27394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27394
cttgagtcaa agtgtaccca                                                   20


<210> 27395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27395
tggtcagatt ccttgagtca                                                   20


<210> 27396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27396
cttctttggt cagattcctt                                                   20


<210> 27397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27397
cccttagaat cttctttggt                                                   20


<210> 27398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27398
atttccctta gaatcttctt                                                   20


<210> 27399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27399
atagacctaa acatttccct                                                   20


<210> 27400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27400
aaaattgact cctgcagtta                                                   20


<210> 27401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27401
tatttgaaaa ttgactcctg                                                   20


<210> 27402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27402
tattaccaca acctcaagtc                                                   20


<210> 27403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27403
acagctatta ccacaacctc                                                   20


<210> 27404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27404
agaaaggatt tacctggtca                                                   20


<210> 27405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27405
gaactcagaa aggatttacc                                                   20


<210> 27406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27406
gcatccctgt gaactcagaa                                                   20


<210> 27407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27407
tgcatccctg tgaactcaga                                                   20


<210> 27408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27408
cgactgcatc cctgtgaact                                                   20


<210> 27409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27409
caaataagta ccttctcact                                                   20


<210> 27410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27410
gagatccgga tcttgcaaat                                                   20


<210> 27411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 27411
tctaattgtt ggtggagatc                                                   20


<210> 27412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27412
ctagtttcta attgttggtg                                                   20


<210> 27413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27413
atctagtttc taattgttgg                                                   20


<210> 27414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27414
aatatctagt ttctaattgt                                                   20


<210> 27415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27415
tggaaaaagg caggaatatc                                                   20


<210> 27416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27416
atttatcttt ggaaaaaggc                                                   20


<210> 27417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27417
tatttatctt tggaaaaagg                                                   20


<210> 27418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27418
ttctatttat ctttggaaaa                                                   20


<210> 27419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27419
cttctattta tctttggaaa                                                   20


<210> 27420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27420
tcttcccttc tatttatctt                                                   20


<210> 27421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27421
tccccatgtg ctcgctgagt                                                   20


<210> 27422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27422
tttttcccca tgtgctcgct                                                   20


<210> 27423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27423
aagaccagaa gttcttttct                                                   20


<210> 27424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27424
aattgacatt tgaagaccag                                                   20


<210> 27425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27425
acaaattgac atttgaagac                                                   20


<210> 27426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27426
cccaaacaaa ttgacatttg                                                   20


<210> 27427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27427
agataatttt gcttttgctg                                                   20


<210> 27428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27428
atctttgtca atgtctatat                                                   20


<210> 27429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27429
cataaaccat gaataacttt                                                   20


<210> 27430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27430
tcataaacca tgaataactt                                                   20


<210> 27431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27431
tttttagggc cagagaatct                                                   20


<210> 27432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27432
ccagttcatt tttagggcca                                                   20


<210> 27433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27433
caccagttca tttttagggc                                                   20


<210> 27434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27434
caggcaccag ttcattttta                                                   20


<210> 27435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27435
gcaggcacca gttcattttt                                                   20


<210> 27436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27436
ggcaggcacc agttcatttt                                                   20


<210> 27437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27437
tatggatgtg aggcaggcac                                                   20


<210> 27438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27438
tttgactatg gatgtgaggc                                                   20


<210> 27439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27439
ttttgactat ggatgtgagg                                                   20


<210> 27440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27440
agtttttgac tatggatgtg                                                   20


<210> 27441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27441
cagtttttga ctatggatgt                                                   20


<210> 27442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27442
aaaatgccag tttttgacta                                                   20


<210> 27443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27443
actcagggta aacaaaatgc                                                   20


<210> 27444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27444
gtgctggtca cactaactca                                                   20


<210> 27445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27445
agtgctggtc acactaactc                                                   20


<210> 27446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27446
cagtgctggt cacactaact                                                   20


<210> 27447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27447
atctctaaaa tgtacagtgc                                                   20


<210> 27448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27448
agagtgatct ctaaaatgta                                                   20


<210> 27449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27449
aattagtaaa attgatgcca                                                   20


<210> 27450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27450
ccaattagta aaattgatgc                                                   20


<210> 27451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27451
tggaagatat aagatccaat                                                   20


<210> 27452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27452
aacagacttc tggaagatat                                                   20


<210> 27453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27453
ggtgatcaac agacttctgg                                                   20


<210> 27454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27454
gaaggtgatc aacagacttc                                                   20


<210> 27455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27455
ataggcaaga aggtgatcaa                                                   20


<210> 27456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27456
agactcaagg ataggcaaga                                                   20


<210> 27457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27457
aagactcaag gataggcaag                                                   20


<210> 27458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27458
tagaagactc aaggataggc                                                   20


<210> 27459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27459
gacatagaag actcaaggat                                                   20


<210> 27460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27460
ggacatagaa gactcaagga                                                   20


<210> 27461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27461
aactggacat agaagactca                                                   20


<210> 27462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27462
gaactggaca tagaagactc                                                   20


<210> 27463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27463
aatggttgaa ctggacatag                                                   20


<210> 27464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27464
caaaatggtt gaactggaca                                                   20


<210> 27465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27465
agaaaccaaa atggttgaac                                                   20


<210> 27466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27466
actattttga gaaaccaaaa                                                   20


<210> 27467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27467
gctttaaaaa caactatttt                                                   20


<210> 27468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27468
cttcaaagac ttaatgaaac                                                   20


<210> 27469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27469
tcattgtcat caaaacttca                                                   20


<210> 27470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27470
agtaaataca caataaatta                                                   20


<210> 27471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27471
ctgcttatta gcctggcata                                                   20


<210> 27472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27472
atgctttctg cttattagcc                                                   20


<210> 27473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27473
attaaatgct ttctgcttat                                                   20


<210> 27474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27474
tcatttatca tattcttggg                                                   20


<210> 27475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27475
ttcatttatc atattcttgg                                                   20


<210> 27476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27476
atttcattta tcatattctt                                                   20


<210> 27477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27477
tatttcattt atcatattct                                                   20


<210> 27478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27478
ggacaaatat tttaactctg                                                   20


<210> 27479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27479
ttatatgagt gatatgccct                                                   20


<210> 27480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27480
atgctgattc tgcattatat                                                   20


<210> 27481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27481
cctcagagtc ccaaagtcct                                                   20


<210> 27482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27482
tcctcagagt cccaaagtcc                                                   20


<210> 27483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27483
tttgggtcct cagagtccca                                                   20


<210> 27484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27484
gtgaagtgtt tgggtcctca                                                   20


<210> 27485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27485
tagtgaagtg tttgggtcct                                                   20


<210> 27486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27486
ataatagtag tgaagtgttt                                                   20


<210> 27487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27487
cataatagta gtgaagtgtt                                                   20


<210> 27488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27488
gctttgacat aatagtagtg                                                   20


<210> 27489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27489
gtattgcttt gacataatag                                                   20


<210> 27490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27490
gatgtattgc tttgacataa                                                   20


<210> 27491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27491
acatattttc agaaaaccta                                                   20


<210> 27492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27492
gtacacacct cacatatttt                                                   20


<210> 27493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27493
ttacattgct gctttcttgt                                                   20


<210> 27494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27494
ggagcaacac ttaacatttt                                                   20


<210> 27495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27495
tctgccagca tatttcttgg                                                   20


<210> 27496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27496
tttctgccag catatttctt                                                   20


<210> 27497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27497
ttttctgcca gcatatttct                                                   20


<210> 27498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27498
ttgataatga ttttttctgc                                                   20


<210> 27499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27499
ataaaaggtt accatcttgg                                                   20


<210> 27500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27500
ctataaaagg ttaccatctt                                                   20


<210> 27501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27501
tctataaaag gttaccatct                                                   20


<210> 27502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27502
aacaatacta tttctataaa                                                   20


<210> 27503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27503
taacaatact atttctataa                                                   20


<210> 27504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27504
ataattgtgc agtactgttg                                                   20


<210> 27505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27505
aataattgtg cagtactgtt                                                   20


<210> 27506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27506
tgtcttttaa aataattgtg                                                   20


<210> 27507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27507
gatgtgtaga gtcaagtttc                                                   20


<210> 27508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27508
atgaatggat gtgtagagtc                                                   20


<210> 27509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27509
tccatatgaa tggatgtgta                                                   20


<210> 27510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27510
tttccatatg aatggatgtg                                                   20


<210> 27511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27511
tccagaactt tccatatgaa                                                   20


<210> 27512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27512
gcctcagaat tatgcatatc                                                   20


<210> 27513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27513
gtcagatgaa tctgcagcct                                                   20


<210> 27514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27514
ttttatgtca gatgaatctg                                                   20


<210> 27515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27515
tcatttcata ttttttatgt                                                   20


<210> 27516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27516
gtactcatag tttctctttt                                                   20


<210> 27517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27517
tattgtgtgt tatgtactca                                                   20


<210> 27518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27518
cttgctatag gaaatttggt                                                   20


<210> 27519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27519
tgtacttgct ataggaaatt                                                   20


<210> 27520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27520
ttcaaaaatg tacttgctat                                                   20


<210> 27521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27521
attcaaaaat gtacttgcta                                                   20


<210> 27522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27522
ggaacaccac ccaatgactg                                                   20


<210> 27523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27523
tggaacacca cccaatgact                                                   20


<210> 27524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27524
aaacacatta tttatggcta                                                   20


<210> 27525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27525
agttttaaac acattattta                                                   20


<210> 27526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27526
tcttgcaatt accatttgca                                                   20


<210> 27527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27527
tattgtaatg gatccttttg                                                   20


<210> 27528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27528
gtgtatctat tttattgtaa                                                   20


<210> 27529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27529
catattggat aaaattcaaa                                                   20


<210> 27530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27530
tctggaattg ctctccatat                                                   20


<210> 27531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27531
ttgcacacaa attcttgatc                                                   20


<210> 27532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27532
aaatgtccac cttggtggta                                                   20


<210> 27533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27533
gacaaaaatg tccaccttgg                                                   20


<210> 27534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27534
ccagacaaaa atgtccacct                                                   20


<210> 27535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27535
ctcccagaac ttgaagagtc                                                   20


<210> 27536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27536
tttttctccc agaacttgaa                                                   20


<210> 27537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27537
cttttttctc ccagaacttg                                                   20


<210> 27538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27538
tgttctctgc ttttttctcc                                                   20


<210> 27539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27539
ttaggagtga aacagacaaa                                                   20


<210> 27540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27540
gtatctggtt aggagtgaaa                                                   20


<210> 27541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27541
actgatttgt atctggttag                                                   20


<210> 27542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27542
tgactgattt gtatctggtt                                                   20


<210> 27543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27543
ctgactgatt tgtatctggt                                                   20


<210> 27544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27544
atgcctgact gatttgtatc                                                   20


<210> 27545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27545
tataaacctt gtttcaatat                                                   20


<210> 27546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27546
aggctatgct ttcattgaaa                                                   20


<210> 27547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27547
tcataataga cttacataag                                                   20


<210> 27548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27548
gtcataatag acttacataa                                                   20


<210> 27549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27549
atgtcataat agacttacat                                                   20


<210> 27550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27550
aggcaacgaa catgtcataa                                                   20


<210> 27551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27551
ccctctctta tgcttcatct                                                   20


<210> 27552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27552
accctctctt atgcttcatc                                                   20


<210> 27553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27553
gatgcccaca tatgtgcttg                                                   20


<210> 27554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27554
ttaggtgcat ttttctctga                                                   20


<210> 27555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27555
cctgtttacc atcacatgtt                                                   20


<210> 27556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27556
tcctgtttac catcacatgt                                                   20


<210> 27557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27557
atttctctgt taaggaaaca                                                   20


<210> 27558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27558
aaacatacat ttctctgtta                                                   20


<210> 27559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27559
aaaacataca tttctctgtt                                                   20


<210> 27560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27560
gtgaaaaata tgcatattgg                                                   20


<210> 27561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27561
caggtgaaaa atatgcatat                                                   20


<210> 27562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27562
tgtcatggga ctaaaaacac                                                   20


<210> 27563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27563
ttgtcatggg actaaaaaca                                                   20


<210> 27564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27564
tctcatctta ttgttgtcat                                                   20


<210> 27565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27565
gtctcatctt attgttgtca                                                   20


<210> 27566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27566
agagtttttt ctggacagaa                                                   20


<210> 27567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27567
cagcaagagt tttttctgga                                                   20


<210> 27568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27568
attacagcaa gagttttttc                                                   20


<210> 27569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27569
cctgtgaact attacagcaa                                                   20


<210> 27570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27570
cacctgtgaa ctattacagc                                                   20


<210> 27571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27571
ttttcacctg tgaactatta                                                   20


<210> 27572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27572
atttctagtt gcttggttct                                                   20


<210> 27573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27573
tatttctagt tgcttggttc                                                   20


<210> 27574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27574
ataaattatt tctagttgct                                                   20


<210> 27575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27575
agtcctccat aaattatttc                                                   20


<210> 27576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27576
gtgtgaaatg tctatttcat                                                   20


<210> 27577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27577
gtgagaagta aatgggctaa                                                   20


<210> 27578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27578
ataaatggtg agaagtaaat                                                   20


<210> 27579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27579
aataaatggt gagaagtaaa                                                   20


<210> 27580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27580
tctcctaaat aaatggtgag                                                   20


<210> 27581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27581
tcatctccta aataaatggt                                                   20


<210> 27582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27582
ctactcatct cctaaataaa                                                   20


<210> 27583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27583
acattcccat tgtgggggca                                                   20


<210> 27584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27584
cccccacatt cccattgtgg                                                   20


<210> 27585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27585
ccccccacat tcccattgtg                                                   20


<210> 27586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27586
accccccaca ttcccattgt                                                   20


<210> 27587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27587
caccccccac attcccattg                                                   20


<210> 27588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27588
ccaggtccca cctggtccct                                                   20


<210> 27589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27589
cccaggtccc acctggtccc                                                   20


<210> 27590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27590
aatatgcccc aggtcccacc                                                   20


<210> 27591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27591
ctcccctgac aatatgcccc                                                   20


<210> 27592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27592
tctcccctga caatatgccc                                                   20


<210> 27593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27593
gacaacttta caaactgtgc                                                   20


<210> 27594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27594
aataagcaaa gatagtcaaa                                                   20


<210> 27595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27595
taataagcaa agatagtcaa                                                   20


<210> 27596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27596
ctaataagca aagatagtca                                                   20


<210> 27597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27597
tctcttctaa taagcaaaga                                                   20


<210> 27598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27598
attgtctctt ctaataagca                                                   20


<210> 27599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27599
caaaaattgt ctcttctaat                                                   20


<210> 27600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27600
cagaaaacaa ggttaaccca                                                   20


<210> 27601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27601
tgcagaaaac aaggttaacc                                                   20


<210> 27602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27602
agtaattgat gcagaaaaca                                                   20


<210> 27603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27603
tagtaattga tgcagaaaac                                                   20


<210> 27604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27604
tgatttaata gtaattgatg                                                   20


<210> 27605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27605
ttcaaagata agtgatttaa                                                   20


<210> 27606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27606
tgatctgacc tttcaaagat                                                   20


<210> 27607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27607
ttgggtgatc tgacctttca                                                   20


<210> 27608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27608
aacccacaaa gacagatgtt                                                   20


<210> 27609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27609
aaacccacaa agacagatgt                                                   20


<210> 27610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27610
aaaaagaaaa cccacaaaga                                                   20


<210> 27611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27611
tgaaaaaaag aaaacccaca                                                   20


<210> 27612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27612
tgactttgca aaatgaaaaa                                                   20


<210> 27613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27613
aaacacagac attgataaca                                                   20


<210> 27614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27614
aaattatttg ctattaaaca                                                   20


<210> 27615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27615
tgtttttatg tgcttaaaaa                                                   20


<210> 27616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27616
agataaccaa tggatactga                                                   20


<210> 27617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27617
atgatggtaa agataaccaa                                                   20


<210> 27618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27618
aatggtttta aatgatggta                                                   20


<210> 27619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27619
cataaaatgg ttttaaatga                                                   20


<210> 27620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27620
agaattcaga gaccataaaa                                                   20


<210> 27621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27621
aaattcttag gaagaattca                                                   20


<210> 27622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27622
tgaaattctt aggaagaatt                                                   20


<210> 27623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27623
aggcacatga aattcttagg                                                   20


<210> 27624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27624
aataggcaca tgaaattctt                                                   20


<210> 27625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27625
aaataggcac atgaaattct                                                   20


<210> 27626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27626
aaatctggtc aaccttaaat                                                   20


<210> 27627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27627
taaatctggt caaccttaaa                                                   20


<210> 27628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27628
aaataaaatt aacataaatc                                                   20


<210> 27629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27629
aataatcttc ttttactgta                                                   20


<210> 27630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27630
atattaacaa acactgtgga                                                   20


<210> 27631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27631
catattaaca aacactgtgg                                                   20


<210> 27632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27632
aagcatatta acaaacactg                                                   20


<210> 27633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27633
cagagagcaa tgagtagagc                                                   20


<210> 27634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27634
cagacagaga gcaatgagta                                                   20


<210> 27635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27635
ctcagacaga gagcaatgag                                                   20


<210> 27636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27636
aacctcagac agagagcaat                                                   20


<210> 27637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27637
tgatcccaac ctcagacaga                                                   20


<210> 27638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27638
aatgatccca acctcagaca                                                   20


<210> 27639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27639
tgaatgatcc caacctcaga                                                   20


<210> 27640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27640
atgctgaatg atcccaacct                                                   20


<210> 27641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27641
tagttcctat ctcctttcag                                                   20


<210> 27642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27642
gtagttccta tctcctttca                                                   20


<210> 27643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27643
ttgtagttcc tatctccttt                                                   20


<210> 27644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27644
atacacaaga aaaggcgttg                                                   20


<210> 27645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27645
ccaatcaaat acacaagaaa                                                   20


<210> 27646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27646
accaatcaaa tacacaagaa                                                   20


<210> 27647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27647
gcacgaccaa tcaaatacac                                                   20


<210> 27648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27648
attaattgat ttttttttta                                                   20


<210> 27649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27649
cattaattga tttttttttt                                                   20


<210> 27650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27650
acattaattg attttttttt                                                   20


<210> 27651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27651
tttattagga ttctgttctt                                                   20


<210> 27652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27652
tcttatacct acaatttatt                                                   20


<210> 27653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27653
atcttatacc tacaatttat                                                   20


<210> 27654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27654
ctcactacag ctatataagc                                                   20


<210> 27655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27655
attactcact acagctatat                                                   20


<210> 27656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27656
ctacttttaa ttactcacta                                                   20


<210> 27657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27657
taatttgaac ccagcaatct                                                   20


<210> 27658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27658
ataatttgaa cccagcaatc                                                   20


<210> 27659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27659
gcagagccat aatttgaacc                                                   20


<210> 27660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27660
tatacagcca gtaagtagca                                                   20


<210> 27661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27661
gatatacagc cagtaagtag                                                   20


<210> 27662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27662
tatgatatac agccagtaag                                                   20


<210> 27663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27663
tcctatgata tacagccagt                                                   20


<210> 27664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27664
gctctcctat gatatacagc                                                   20


<210> 27665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27665
agtagctctc ctatgatata                                                   20


<210> 27666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27666
ataaaactga gacagttaag                                                   20


<210> 27667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27667
aatataaaac tgagacagtt                                                   20


<210> 27668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27668
ttaccaatat aaaactgaga                                                   20


<210> 27669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27669
cattttacca atataaaact                                                   20


<210> 27670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27670
tcctcacaag aatatgaagc                                                   20


<210> 27671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27671
ttaatcctca caagaatatg                                                   20


<210> 27672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27672
ttaattcctt taatcctcac                                                   20


<210> 27673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27673
tgatataaca aaaaagcagc                                                   20


<210> 27674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27674
gtgatgatat aacaaaaaag                                                   20


<210> 27675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27675
atagtgatga tataacaaaa                                                   20


<210> 27676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27676
gaaaggcaga gaggtgatga                                                   20


<210> 27677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27677
gaacactcag aaaggcagag                                                   20


<210> 27678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27678
tgaacactca gaaaggcaga                                                   20


<210> 27679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27679
attgaacact cagaaaggca                                                   20


<210> 27680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27680
aaattgaaca ctcagaaagg                                                   20


<210> 27681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27681
aataaattga acactcagaa                                                   20


<210> 27682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27682
gaataaattg aacactcaga                                                   20


<210> 27683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27683
atctgaataa attgaacact                                                   20


<210> 27684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27684
cactttcact gttttcatgt                                                   20


<210> 27685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27685
gcactttcac tgttttcatg                                                   20


<210> 27686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27686
cctttagata cacagcacta                                                   20


<210> 27687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27687
attctacccc tttagataca                                                   20


<210> 27688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27688
atactgagat tctacccctt                                                   20


<210> 27689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27689
gaaatttatc agagaatact                                                   20


<210> 27690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27690
gtaattccag aaatttatca                                                   20


<210> 27691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27691
aagtaattcc agaaatttat                                                   20


<210> 27692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27692
ccctcaataa aaagtaattc                                                   20


<210> 27693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27693
aatgttgttc cctcaataaa                                                   20


<210> 27694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27694
gtaagagaca accattacag                                                   20


<210> 27695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27695
cagtaagaga caaccattac                                                   20


<210> 27696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27696
gcagtaagag acaaccatta                                                   20


<210> 27697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27697
gaggtcttcc ttggcagtaa                                                   20


<210> 27698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27698
atgaggtctt ccttggcagt                                                   20


<210> 27699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27699
gttcatgagg tcttccttgg                                                   20


<210> 27700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27700
tcagttcatg aggtcttcct                                                   20


<210> 27701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27701
tatgctctgc tcagttcatg                                                   20


<210> 27702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27702
atatgctctg ctcagttcat                                                   20


<210> 27703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27703
ttatcatcat atgctctgct                                                   20


<210> 27704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27704
ctaattgttc ctttcaaact                                                   20


<210> 27705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27705
gaggtcacct ctttcagatg                                                   20


<210> 27706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27706
tgaagagagg tcacctcttt                                                   20


<210> 27707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27707
caatttctag agctgaagag                                                   20


<210> 27708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27708
acaatttcta gagctgaaga                                                   20


<210> 27709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27709
caacaatttc tagagctgaa                                                   20


<210> 27710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27710
ggcaacaatt tctagagctg                                                   20


<210> 27711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27711
ttgcatggca acaatttcta                                                   20


<210> 27712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27712
ttttgcatgg caacaatttc                                                   20


<210> 27713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27713
catgagttca tgtttttgca                                                   20


<210> 27714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27714
taaatacact tgttatgcat                                                   20


<210> 27715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27715
agtttccaag ttttaaaaat                                                   20


<210> 27716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27716
ttaaatttga attagtttcc                                                   20


<210> 27717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27717
atagtgtttt aaatttgaat                                                   20


<210> 27718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27718
tggcctgcat ggaaccaaca                                                   20


<210> 27719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27719
gtgtgtattt ctggcctgca                                                   20


<210> 27720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27720
tgagtgtgtg tgtgtatttc                                                   20


<210> 27721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27721
ttgtgtatat atgtgtgtgt                                                   20


<210> 27722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27722
atgatagatc tagagttgta                                                   20


<210> 27723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27723
agacaaacat gatagatcta                                                   20


<210> 27724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27724
gcagacaaac atgatagatc                                                   20


<210> 27725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27725
acacaagcag acaaacatga                                                   20


<210> 27726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27726
taccacatac cacacacaag                                                   20


<210> 27727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27727
atataccaca taccacacac                                                   20


<210> 27728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27728
actatacaac tttacaaatc                                                   20


<210> 27729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27729
tgtgtctgtt cacatacaca                                                   20


<210> 27730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27730
tttacagaga tctctcaaat                                                   20


<210> 27731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27731
ttttacagag atctctcaaa                                                   20


<210> 27732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27732
caaaaagttg actttttaca                                                   20


<210> 27733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27733
ttcaaaaagt tgacttttta                                                   20


<210> 27734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27734
ggttttcgag acttttcaaa                                                   20


<210> 27735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27735
gcacagaaaa cctggttttc                                                   20


<210> 27736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27736
agactatagc acagaaaacc                                                   20


<210> 27737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27737
ttgtttgaca gactatagca                                                   20


<210> 27738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27738
aattcttgtt tgacagacta                                                   20


<210> 27739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27739
tctgacaaat tcttgtttga                                                   20


<210> 27740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27740
atacctgaaa catgtctaca                                                   20


<210> 27741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27741
taaaattgtg gcacaatata                                                   20


<210> 27742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27742
atacagtaaa cataaaattg                                                   20


<210> 27743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27743
tataagatac aatggaaata                                                   20


<210> 27744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27744
tggatactta taagatacaa                                                   20


<210> 27745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27745
aggaattagt ggatacttat                                                   20


<210> 27746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27746
tacaaaacta gaggaattag                                                   20


<210> 27747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27747
aactacaaaa ctagaggaat                                                   20


<210> 27748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27748
agtgaaaact acaaaactag                                                   20


<210> 27749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27749
aagtgaaaac tacaaaacta                                                   20


<210> 27750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27750
taaagtgaaa actacaaaac                                                   20


<210> 27751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27751
cagtatcaca ataaatccta                                                   20


<210> 27752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27752
ttttttcacc atagaaaaat                                                   20


<210> 27753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27753
atttaagagt tttttcacca                                                   20


<210> 27754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27754
aatgaagttt cttcatttaa                                                   20


<210> 27755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27755
ttaatgaagt ttcttcattt                                                   20


<210> 27756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27756
attatttcat atttttaatg                                                   20


<210> 27757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27757
tataatttat atcagattag                                                   20


<210> 27758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27758
tatataattt atatcagatt                                                   20


<210> 27759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27759
ctatataatt tatatcagat                                                   20


<210> 27760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27760
aaatactata taatttatat                                                   20


<210> 27761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27761
atgagcatgt taaatttctg                                                   20


<210> 27762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27762
ggtatttttc attattgaat                                                   20


<210> 27763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27763
acagcttaag cccttctgca                                                   20


<210> 27764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27764
tacagcttaa gcccttctgc                                                   20


<210> 27765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27765
atgtgtgcat gatacagctt                                                   20


<210> 27766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27766
acctctatgt gtgcatgata                                                   20


<210> 27767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27767
gaataaatgc atgtgctttt                                                   20


<210> 27768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27768
tgaataaatg catgtgcttt                                                   20


<210> 27769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27769
gtaaagttcc atcaaatcca                                                   20


<210> 27770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27770
tagtatttca agtgagagta                                                   20


<210> 27771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27771
caatgtagta tttcaagtga                                                   20


<210> 27772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27772
gacaatgtag tatttcaagt                                                   20


<210> 27773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27773
tgcagacaat gtagtatttc                                                   20


<210> 27774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27774
atttatattt gcagacaatg                                                   20


<210> 27775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27775
tgcttatata tttatatttg                                                   20


<210> 27776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27776
agggctttga ctaacccaat                                                   20


<210> 27777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27777
tgcattacca atatcagcaa                                                   20


<210> 27778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27778
ctgcattacc aatatcagca                                                   20


<210> 27779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27779
gctgcattac caatatcagc                                                   20


<210> 27780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27780
ctatgctgca ttaccaatat                                                   20


<210> 27781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27781
gagtttccag gatatctctt                                                   20


<210> 27782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27782
ttctcattcc tggagtttcc                                                   20


<210> 27783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27783
tttctcattc ctggagtttc                                                   20


<210> 27784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27784
tgagatcttt ctcattcctg                                                   20


<210> 27785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27785
agtgagatct ttctcattcc                                                   20


<210> 27786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27786
gtctgattag gcttgaaagt                                                   20


<210> 27787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27787
aggtgtctga ttaggcttga                                                   20


<210> 27788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27788
ttagagaaag gtgtctgatt                                                   20


<210> 27789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27789
gttagagaaa ggtgtctgat                                                   20


<210> 27790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27790
gtcactaagt ggttagagaa                                                   20


<210> 27791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27791
agtcactaag tggttagaga                                                   20


<210> 27792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27792
tacgagtcac taagtggtta                                                   20


<210> 27793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27793
tctacgagtc actaagtggt                                                   20


<210> 27794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27794
aaggtctacg agtcactaag                                                   20


<210> 27795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27795
ccaaaggtct acgagtcact                                                   20


<210> 27796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27796
cagcagttcc aaaggtctac                                                   20


<210> 27797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27797
tcattttaca gcagttccaa                                                   20


<210> 27798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27798
atcattttac agcagttcca                                                   20


<210> 27799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27799
gcaaaacaat cattttacag                                                   20


<210> 27800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27800
aaagcaaaac aatcatttta                                                   20


<210> 27801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27801
attgacacaa acaaacataa                                                   20


<210> 27802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27802
aaacaaaata tctgaaatgc                                                   20


<210> 27803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27803
tttaaaaaat atttcatctg                                                   20


<210> 27804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27804
tttttaaaaa atatttcatc                                                   20


<210> 27805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27805
atttagaatg gctatgtatt                                                   20


<210> 27806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27806
aatttagaat ggctatgtat                                                   20


<210> 27807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27807
tatcttgaaa aaatttagaa                                                   20


<210> 27808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27808
cttcttatct tgaaaaaatt                                                   20


<210> 27809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27809
ctatctctcc aatgtgcagt                                                   20


<210> 27810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27810
gctatctctc caatgtgcag                                                   20


<210> 27811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27811
tctgctatct ctccaatgtg                                                   20


<210> 27812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27812
gaaacggagg ctgtctgttt                                                   20


<210> 27813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27813
tagctcctaa gttgaaacgg                                                   20


<210> 27814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27814
gtagctccta agttgaaacg                                                   20


<210> 27815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 27815
tggtagctcc taagttgaaa                                                   20


<210> 27816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27816
gctaataaat ggtagctcct                                                   20


<210> 27817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27817
tttactcagc taataaatgg                                                   20


<210> 27818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27818
caatttactc agctaataaa                                                   20


<210> 27819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27819
gcaacttgcc ccaatttact                                                   20


<210> 27820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27820
aattgaggca tggggaaatg                                                   20


<210> 27821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27821
aatgggaaaa ttgaggcatg                                                   20


<210> 27822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27822
aaatgggaaa attgaggcat                                                   20


<210> 27823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27823
caaatgggaa aattgaggca                                                   20


<210> 27824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27824
ttttacaaat gggaaaattg                                                   20


<210> 27825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27825
gttttacaaa tgggaaaatt                                                   20


<210> 27826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27826
attatctctg ttttacaaat                                                   20


<210> 27827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27827
tattatctct gttttacaaa                                                   20


<210> 27828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27828
agtatttatg acaaccccat                                                   20


<210> 27829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27829
aataacagca aacacatatt                                                   20


<210> 27830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27830
cttatttgag ttgttaataa                                                   20


<210> 27831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27831
tattccaagg aatcttattt                                                   20


<210> 27832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27832
cttaatatgt acctattcca                                                   20


<210> 27833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27833
gcttaatatg tacctattcc                                                   20


<210> 27834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27834
ctgctatctt tttcaggtca                                                   20


<210> 27835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27835
cagctactgc tatctttttc                                                   20


<210> 27836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27836
ccagctactg ctatcttttt                                                   20


<210> 27837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27837
aagaaatttg gattacttgc                                                   20


<210> 27838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27838
cccatttcta tgaagaaatt                                                   20


<210> 27839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27839
taatagatcc catttctatg                                                   20


<210> 27840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27840
atgctgatat tagttaataa                                                   20


<210> 27841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27841
tgcaaggata atgctgatat                                                   20


<210> 27842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27842
atatcagtac agaaaatgca                                                   20


<210> 27843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27843
gatatcagta cagaaaatgc                                                   20


<210> 27844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27844
tatatagata gatatcagta                                                   20


<210> 27845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27845
atacatatat agatagatat                                                   20


<210> 27846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27846
atgacggata catatataga                                                   20


<210> 27847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27847
atttatgacg gatacatata                                                   20


<210> 27848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 27848
ctttagagaa caatttatga                                                   20


<210> 27849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27849
gattataaat aatctcttta                                                   20


<210> 27850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27850
aagattataa ataatctctt                                                   20


<210> 27851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27851
gtctattaat tttataattg                                                   20


<210> 27852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27852
aaaatcccat ttttgtaaaa                                                   20


<210> 27853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27853
taaaatccca tttttgtaaa                                                   20


<210> 27854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27854
tgttgtaggc atctaactca                                                   20


<210> 27855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27855
atcctcattc tatgtgttgt                                                   20


<210> 27856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27856
aatcctcatt ctatgtgttg                                                   20


<210> 27857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27857
ggaacacacc tttgattcat                                                   20


<210> 27858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27858
ttttgcaata ctttttctat                                                   20


<210> 27859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27859
attttgcaat actttttcta                                                   20


<210> 27860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27860
gccttctctg gtcttgtgaa                                                   20


<210> 27861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27861
ctctgctgaa gggccttctc                                                   20


<210> 27862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27862
cagtcagtct ctctgctgaa                                                   20


<210> 27863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27863
tcagtcagtc tctctgctga                                                   20


<210> 27864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27864
atcagtcagt ctctctgctg                                                   20


<210> 27865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27865
gcccttgttc ctgcatcagt                                                   20


<210> 27866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27866
ctgggccctt gttcctgcat                                                   20


<210> 27867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27867
tacatagctc aggcatggct                                                   20


<210> 27868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27868
ttacatagct caggcatggc                                                   20


<210> 27869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27869
cgttttacat agctcaggca                                                   20


<210> 27870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27870
aaggacgttt tacatagctc                                                   20


<210> 27871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27871
taaggacgtt ttacatagct                                                   20


<210> 27872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27872
cagcgtaagg acgttttaca                                                   20


<210> 27873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27873
caacttctga tgacagcgta                                                   20


<210> 27874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27874
gcaacttctg atgacagcgt                                                   20


<210> 27875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27875
gataaggcaa cttctgatga                                                   20


<210> 27876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27876
gccagaggtg ataatagata                                                   20


<210> 27877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27877
tgccagaggt gataatagat                                                   20


<210> 27878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27878
gcttctgcca gaggtgataa                                                   20


<210> 27879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27879
caatggacag cttctgccag                                                   20


<210> 27880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27880
ccaatggaca gcttctgcca                                                   20


<210> 27881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27881
ccccaatgga cagcttctgc                                                   20


<210> 27882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27882
ccctcatgct ccccaatgga                                                   20


<210> 27883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27883
tcagccctca tgctccccaa                                                   20


<210> 27884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27884
ctccctggtt gatggacgct                                                   20


<210> 27885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27885
ggtgtggtct ccctggttga                                                   20


<210> 27886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27886
ctgcaacggt gtggtctccc                                                   20


<210> 27887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27887
tgctgtggac tgcaacggtg                                                   20


<210> 27888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 27888
cacagtgctg tggactgcaa                                                   20


<210> 27889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27889
cgggaaaatg cacagtgctg                                                   20


<210> 27890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27890
ccggtgaacg ggaaaatgca                                                   20


<210> 27891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27891
caccaatgct gccggtgaac                                                   20


<210> 27892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 27892
ccaccaatgc tgccggtgaa                                                   20


<210> 27893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 27893
taggtcccca ccaatgctgc                                                   20


<210> 27894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27894
gtaacatcag ccaagccagt                                                   20


<210> 27895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27895
agtaacatca gccaagccag                                                   20


<210> 27896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27896
agcagtaaca tcagccaagc                                                   20


<210> 27897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27897
acgcagcagt aacatcagcc                                                   20


<210> 27898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27898
gagcgacgca gcagtaacat                                                   20


<210> 27899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27899
agaccccagg agcgacgcag                                                   20


<210> 27900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27900
cacagacccc aggagcgacg                                                   20


<210> 27901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27901
ttgtgcccca cagaccccag                                                   20


<210> 27902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27902
gtttgtgccc cacagacccc                                                   20


<210> 27903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27903
tgtttgtgcc ccacagaccc                                                   20


<210> 27904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27904
ggctcactgt ttgtgcccca                                                   20


<210> 27905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27905
ggagacaatg agagcagaag                                                   20


<210> 27906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27906
tggagacaat gagagcagaa                                                   20


<210> 27907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27907
ttggagacaa tgagagcaga                                                   20


<210> 27908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27908
tttggagaca atgagagcag                                                   20


<210> 27909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27909
atttttggag acaatgagag                                                   20


<210> 27910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27910
agcatttttg gagacaatga                                                   20


<210> 27911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27911
acagcatttt tggagacaat                                                   20


<210> 27912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27912
tgatgagcac agcatttttg                                                   20


<210> 27913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27913
gatgatgagc acagcatttt                                                   20


<210> 27914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27914
gaatttgccg atgatgagca                                                   20


<210> 27915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27915
agactgaatt tgccgatgat                                                   20


<210> 27916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27916
gaggaagaga tataggatct                                                   20


<210> 27917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27917
aaaggcagag gaagagatat                                                   20


<210> 27918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27918
caaaggcaga ggaagagata                                                   20


<210> 27919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27919
tagtttcaaa ggcagaggaa                                                   20


<210> 27920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27920
tttagtttca aaggcagagg                                                   20


<210> 27921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27921
ctttttagtt tcaaaggcag                                                   20


<210> 27922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27922
tctttttagt ttcaaaggca                                                   20


<210> 27923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27923
agtcttttta gtttcaaagg                                                   20


<210> 27924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27924
acaagtcttt ttagtttcaa                                                   20


<210> 27925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27925
aacaagtctt tttagtttca                                                   20


<210> 27926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27926
agcagcagaa caagtctttt                                                   20


<210> 27927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27927
gcaaggcgaa gcagcagaac                                                   20


<210> 27928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27928
ttttctgcaa ggcgaagcag                                                   20


<210> 27929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27929
ttgttttctg caaggcgaag                                                   20


<210> 27930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27930
tccttgtttt ctgcaaggcg                                                   20


<210> 27931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27931
gtggctcctt gttttctgca                                                   20


<210> 27932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27932
cgtggctcct tgttttctgc                                                   20


<210> 27933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27933
cagtcaccac tcagcattcg                                                   20


<210> 27934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27934
atttttctgc agtcaccact                                                   20


<210> 27935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27935
cgtttttttt aatttttctg                                                   20


<210> 27936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27936
acttctatca gtaggtgctt                                                   20


<210> 27937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27937
tgaagtgtac ttctatcagt                                                   20


<210> 27938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27938
atgaagtgta cttctatcag                                                   20


<210> 27939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27939
tatatgaagt gtacttctat                                                   20


<210> 27940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27940
ggttcagtgg tatttatatg                                                   20


<210> 27941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27941
cctcaggcca gtgggttcag                                                   20


<210> 27942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27942
tgccctcagg ccagtgggtt                                                   20


<210> 27943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27943
ccacctgccc tcaggccagt                                                   20


<210> 27944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27944
gccacctgcc ctcaggccag                                                   20


<210> 27945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27945
agagccacct gccctcaggc                                                   20


<210> 27946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27946
gtacagagcc acctgccctc                                                   20


<210> 27947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27947
agtacagagc cacctgccct                                                   20


<210> 27948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27948
gtttctttta agtcagtaca                                                   20


<210> 27949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27949
atgtttcttt taagtcagta                                                   20


<210> 27950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27950
taagtatgtt tcttttaagt                                                   20


<210> 27951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27951
tttttaagta tgtttctttt                                                   20


<210> 27952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27952
cactgaattg cttcgttttt                                                   20


<210> 27953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27953
tttcatccct taagtggaag                                                   20


<210> 27954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27954
ttgtttcatc ccttaagtgg                                                   20


<210> 27955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27955
aaattgtttc atcccttaag                                                   20


<210> 27956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27956
tacaaattgt ttcatccctt                                                   20


<210> 27957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27957
ataatttacc tggtcctgaa                                                   20


<210> 27958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27958
aataatttac ctggtcctga                                                   20


<210> 27959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27959
atagcaacaa ataatttacc                                                   20


<210> 27960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27960
cagaatatta gagagctgta                                                   20


<210> 27961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27961
ctctaggcca gaatattaga                                                   20


<210> 27962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27962
aactctaggc cagaatatta                                                   20


<210> 27963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27963
gtaactctag gccagaatat                                                   20


<210> 27964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27964
atggagcagt aactctaggc                                                   20


<210> 27965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27965
aagaatggag cagtaactct                                                   20


<210> 27966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27966
aaagaatgga gcagtaactc                                                   20


<210> 27967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27967
atggcattaa aagaatggag                                                   20


<210> 27968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27968
tgaatggcat taaaagaatg                                                   20


<210> 27969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27969
aatgaatggc attaaaagaa                                                   20


<210> 27970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27970
agcaaaatga atggcattaa                                                   20


<210> 27971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27971
gttctgtgca gcaaaatgaa                                                   20


<210> 27972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27972
tttaagttat aagttctgtg                                                   20


<210> 27973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27973
aagttctttt tttaagttat                                                   20


<210> 27974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27974
caatactaag ttcttttttt                                                   20


<210> 27975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27975
gaatgaccag tagcaatact                                                   20


<210> 27976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27976
ataaaaagtt gaatgaccag                                                   20


<210> 27977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27977
tatataaaaa gttgaatgac                                                   20


<210> 27978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27978
cctggggatt gatatataaa                                                   20


<210> 27979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27979
caattttttt gtgaagcctg                                                   20


<210> 27980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27980
ccaatttttt tgtgaagcct                                                   20


<210> 27981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27981
tccaattttt ttgtgaagcc                                                   20


<210> 27982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27982
tgatttccaa tttttttgtg                                                   20


<210> 27983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 27983
tttcaatgca aagaaccata                                                   20


<210> 27984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27984
taaggtggat tttcaatgca                                                   20


<210> 27985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27985
tgagctctta gtatgtaagg                                                   20


<210> 27986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27986
aactgagctc ttagtatgta                                                   20


<210> 27987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27987
taactgagct cttagtatgt                                                   20


<210> 27988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 27988
atacacttta actgagctct                                                   20


<210> 27989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27989
tctttaaata cactttaact                                                   20


<210> 27990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27990
tataaattaa ctggtgctaa                                                   20


<210> 27991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27991
taatgacttt ataaattaac                                                   20


<210> 27992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 27992
ttttcctcct ctttggtatt                                                   20


<210> 27993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27993
tttttcctcc tctttggtat                                                   20


<210> 27994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27994
attgaatttt tcctcctctt                                                   20


<210> 27995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27995
accctggaca tgagtcatat                                                   20


<210> 27996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 27996
aggatttaca ccctggacat                                                   20


<210> 27997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 27997
cttccaaagg atttacaccc                                                   20


<210> 27998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 27998
attgaactag atccttccaa                                                   20


<210> 27999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 27999
tattgaacta gatccttcca                                                   20


<210> 28000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28000
agcactaatg tctattgaac                                                   20


<210> 28001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28001
cactttgttc tttacatagt                                                   20


<210> 28002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28002
ttgccacttt gttctttaca                                                   20


<210> 28003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28003
actttttcca ttgttcacaa                                                   20


<210> 28004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28004
tccaagctgg ttttgaggca                                                   20


<210> 28005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28005
agcagtccaa gctggttttg                                                   20


<210> 28006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28006
gagcagtcca agctggtttt                                                   20


<210> 28007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28007
atgacaggag cagtccaagc                                                   20


<210> 28008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28008
aaatatgaca ggagcagtcc                                                   20


<210> 28009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28009
aaaaataaat atgacaggag                                                   20


<210> 28010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28010
aataaaaata aatatgacag                                                   20


<210> 28011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28011
tcaataaaaa taaatatgac                                                   20


<210> 28012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28012
atcaataaaa ataaatatga                                                   20


<210> 28013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28013
ctaggtgatg atacagaact                                                   20


<210> 28014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28014
cttgaaccta ggtgatgata                                                   20


<210> 28015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28015
tcaaaatttc acttgaacct                                                   20


<210> 28016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28016
ttcaaaattt cacttgaacc                                                   20


<210> 28017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28017
atacacagta aaaaaagata                                                   20


<210> 28018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28018
atatacacag taaaaaaaga                                                   20


<210> 28019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28019
cctgatatac acagtaaaaa                                                   20


<210> 28020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28020
caagattctc ctgatataca                                                   20


<210> 28021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28021
aaatctagtt aaaaatctac                                                   20


<210> 28022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28022
acttttctaa actaaaaatc                                                   20


<210> 28023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28023
ccattgcttc tgttttcctt                                                   20


<210> 28024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28024
accattgctt ctgttttcct                                                   20


<210> 28025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28025
ataattctgc acaaatcccc                                                   20


<210> 28026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28026
cactgaaacc ttcatctctc                                                   20


<210> 28027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28027
tcactgaaac cttcatctct                                                   20


<210> 28028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28028
tgttaattct gtttatgtgg                                                   20


<210> 28029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28029
gtctgttaat tctgtttatg                                                   20


<210> 28030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28030
actactaata tgtagtgcca                                                   20


<210> 28031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28031
ccacatcaac tactaatatg                                                   20


<210> 28032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28032
acccatttgg aactttggag                                                   20


<210> 28033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28033
ctcacccatt tggaactttg                                                   20


<210> 28034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28034
cactcaccca tttggaactt                                                   20


<210> 28035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28035
aatagtatca ctcacccatt                                                   20


<210> 28036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28036
ttcttaaaca gtataggtaa                                                   20


<210> 28037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28037
tcttctttct taaacagtat                                                   20


<210> 28038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28038
ctcttctttc ttaaacagta                                                   20


<210> 28039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28039
agtttctctt ctttcttaaa                                                   20


<210> 28040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28040
gttaaaaact aatcttagac                                                   20


<210> 28041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28041
cattggttaa aaactaatct                                                   20


<210> 28042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28042
tgtgttttgt aatgcttcat                                                   20


<210> 28043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28043
ataactttta tatttgtatt                                                   20


<210> 28044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28044
taaagagacc attcacacta                                                   20


<210> 28045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28045
agaaccattg tagaaataaa                                                   20


<210> 28046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28046
tgagaaccat tgtagaaata                                                   20


<210> 28047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28047
aatgttcctg agaaccattg                                                   20


<210> 28048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28048
ttcagaagca aaatgttcct                                                   20


<210> 28049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28049
tctaataaac taattttcag                                                   20


<210> 28050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28050
ttctctaata aactaatttt                                                   20


<210> 28051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28051
tttgaaagac cttatagttt                                                   20


<210> 28052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28052
atcatttttg aaagacctta                                                   20


<210> 28053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28053
ttgggttcaa tcatttttga                                                   20


<210> 28054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28054
atgtacacag gtttccattt                                                   20


<210> 28055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28055
gatgtacaca ggtttccatt                                                   20


<210> 28056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28056
atttatggaa agatgtacac                                                   20


<210> 28057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28057
catttatgga aagatgtaca                                                   20


<210> 28058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28058
tatcgctagg catttatgga                                                   20


<210> 28059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28059
ctagtatcgc taggcattta                                                   20


<210> 28060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28060
ggtaaaaacc tagtatcgct                                                   20


<210> 28061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28061
aggtaaaaac ctagtatcgc                                                   20


<210> 28062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28062
tatgatttta ggtaaaaacc                                                   20


<210> 28063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28063
gatttcattg gtatgatttt                                                   20


<210> 28064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28064
tgatttcatt ggtatgattt                                                   20


<210> 28065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28065
aggatagtga gtgatttcat                                                   20


<210> 28066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28066
agaactcggg agaggatagt                                                   20


<210> 28067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28067
taagagaact cgggagagga                                                   20


<210> 28068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28068
agggtaagag aactcgggag                                                   20


<210> 28069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28069
tagggtaaga gaactcggga                                                   20


<210> 28070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28070
tttagggtaa gagaactcgg                                                   20


<210> 28071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28071
attttagggt aagagaactc                                                   20


<210> 28072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 28072
tattttaggg taagagaact                                                   20


<210> 28073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28073
aatgtcttat tttagggtaa                                                   20


<210> 28074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28074
aaaatgtctt attttagggt                                                   20


<210> 28075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28075
gagaaaaatg tcttatttta                                                   20


<210> 28076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28076
agagaaaaat gtcttatttt                                                   20


<210> 28077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28077
tagagaaaaa tgtcttattt                                                   20


<210> 28078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28078
tcacccgagg cagaatgcta                                                   20


<210> 28079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28079
tatcacccga ggcagaatgc                                                   20


<210> 28080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28080
taaatgtgta tcacccgagg                                                   20


<210> 28081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28081
tgctaaatgt gtatcacccg                                                   20


<210> 28082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28082
ttgctaaatg tgtatcaccc                                                   20


<210> 28083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28083
gaggttgtct acccccaatc                                                   20


<210> 28084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28084
agaggttgtc tacccccaat                                                   20


<210> 28085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28085
ataggcgagc acatgaaaag                                                   20


<210> 28086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28086
cataggcgag cacatgaaaa                                                   20


<210> 28087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28087
ggcataggcg agcacatgaa                                                   20


<210> 28088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28088
tggtgtcgaa gggcataggc                                                   20


<210> 28089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28089
accttggtgt cgaagggcat                                                   20


<210> 28090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28090
caccttggtg tcgaagggca                                                   20


<210> 28091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28091
gtttccacct tggtgtcgaa                                                   20


<210> 28092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28092
agtttccacc ttggtgtcga                                                   20


<210> 28093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28093
aagtttccac cttggtgtcg                                                   20


<210> 28094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28094
agaagaaaaa gtttccacct                                                   20


<210> 28095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28095
gaggacagca tcagaagaaa                                                   20


<210> 28096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28096
gaatcagagg acagcatcag                                                   20


<210> 28097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28097
tcagaatcag aggacagcat                                                   20


<210> 28098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28098
tcgaaatcag aatcagagga                                                   20


<210> 28099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28099
attgtcgaaa tcagaatcag                                                   20


<210> 28100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28100
aattgtcgaa atcagaatca                                                   20


<210> 28101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28101
gaaattgtcg aaatcagaat                                                   20


<210> 28102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28102
tgctgagaaa ttgtcgaaat                                                   20


<210> 28103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28103
gagaggaaaa gggagatgct                                                   20


<210> 28104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28104
ctccagtgga gaggaaaagg                                                   20


<210> 28105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28105
ctctccagtg gagaggaaaa                                                   20


<210> 28106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28106
gctctccagt ggagaggaaa                                                   20


<210> 28107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28107
agctctccag tggagaggaa                                                   20


<210> 28108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28108
aaagaagctc tccagtggag                                                   20


<210> 28109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28109
aaaagaagct ctccagtgga                                                   20


<210> 28110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28110
tcaaaagaag ctctccagtg                                                   20


<210> 28111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28111
aatcaaaaga agctctccag                                                   20


<210> 28112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28112
aagaatcaaa agaagctctc                                                   20


<210> 28113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28113
gaaagaaaaa gaatcaaaag                                                   20


<210> 28114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28114
gaagaaagaa aaagaatcaa                                                   20


<210> 28115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28115
gaagaaacag aagaaagaaa                                                   20


<210> 28116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28116
aagaaagaag aaacagaaga                                                   20


<210> 28117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28117
gctaaagaaa gaagaaacag                                                   20


<210> 28118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28118
agtgctaaag aaagaagaaa                                                   20


<210> 28119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28119
tctaaaagtg ctaaagaaag                                                   20


<210> 28120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28120
agctctaaaa gtgctaaaga                                                   20


<210> 28121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28121
actgagctct aaaagtgcta                                                   20


<210> 28122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28122
acatccaaac tgagctctaa                                                   20


<210> 28123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28123
tcttctgaaa catccaaact                                                   20


<210> 28124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28124
agaattatgg gcctctcaga                                                   20


<210> 28125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28125
gcagaattat gggcctctca                                                   20


<210> 28126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28126
aagcagaatt atgggcctct                                                   20


<210> 28127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28127
attaggagaa gcagaattat                                                   20


<210> 28128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28128
tattaggaga agcagaatta                                                   20


<210> 28129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28129
tatacaagta ttaggagaag                                                   20


<210> 28130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28130
gaatatacaa gtattaggag                                                   20


<210> 28131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28131
gctgaatata caagtattag                                                   20


<210> 28132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28132
cggctgaata tacaagtatt                                                   20


<210> 28133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28133
gcggctgaat atacaagtat                                                   20


<210> 28134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28134
gcggcagcgg ctgaatatac                                                   20


<210> 28135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 28135
ccaggcaatt gcagcggcag                                                   20


<210> 28136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28136
caaccaggca attgcagcgg                                                   20


<210> 28137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 28137
gcccaaccag gcaattgcag                                                   20


<210> 28138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28138
ttggcccaac caggcaattg                                                   20


<210> 28139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28139
gttaacgtct tggcccaacc                                                   20


<210> 28140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28140
tgttaacgtc ttggcccaac                                                   20


<210> 28141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28141
tcatttaagt gttaacgtct                                                   20


<210> 28142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28142
gatttggaaa tgactcattt                                                   20


<210> 28143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28143
tcctagggtt tcctaggatt                                                   20


<210> 28144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28144
gtcctgtcct agggtttcct                                                   20


<210> 28145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28145
tgtcctgtcc tagggtttcc                                                   20


<210> 28146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28146
gtgaaagatg tcctgtccta                                                   20


<210> 28147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28147
ggtgaaagat gtcctgtcct                                                   20


<210> 28148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28148
aggtgaaaga tgtcctgtcc                                                   20


<210> 28149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28149
gttgttatgc taataggtga                                                   20


<210> 28150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28150
caccatgttg ttatgctaat                                                   20


<210> 28151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28151
gcaccatgtt gttatgctaa                                                   20


<210> 28152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28152
aacgatcatt tcatgtttaa                                                   20


<210> 28153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28153
aaacgatcat ttcatgttta                                                   20


<210> 28154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28154
agcattctga tcattgtgta                                                   20


<210> 28155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28155
aaaccaaata tatactttgt                                                   20


<210> 28156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28156
atagagcttt atttcaacct                                                   20


<210> 28157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28157
tttaattcta aaatacaata                                                   20


<210> 28158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28158
agtttaattc taaaatacaa                                                   20


<210> 28159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28159
agcaaattaa taacatgtaa                                                   20


<210> 28160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28160
atttaatttg tctttactgt                                                   20


<210> 28161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28161
tcttattgca tggtttatgc                                                   20


<210> 28162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28162
aaattgtctg tcttattgca                                                   20


<210> 28163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28163
ctgattctat tgatgatatg                                                   20


<210> 28164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28164
gcctgattct attgatgata                                                   20


<210> 28165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28165
tcaatcttta ttaaaccata                                                   20


<210> 28166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28166
actcaatctt tattaaacca                                                   20


<210> 28167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28167
agaagtttca tttaggccaa                                                   20


<210> 28168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28168
aattcccaga agtttcattt                                                   20


<210> 28169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28169
gaattcccag aagtttcatt                                                   20


<210> 28170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28170
actacctagg gaattcccag                                                   20


<210> 28171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28171
ggtactacct agggaattcc                                                   20


<210> 28172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28172
gttatcccag gtactaccta                                                   20


<210> 28173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28173
ggttatccca ggtactacct                                                   20


<210> 28174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28174
aggttatccc aggtactacc                                                   20


<210> 28175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28175
ggatagtact aggttatccc                                                   20


<210> 28176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28176
gggatagtac taggttatcc                                                   20


<210> 28177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28177
ttttgtaaag ggatagtact                                                   20


<210> 28178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28178
attttgtaaa gggatagtac                                                   20


<210> 28179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28179
caaaacattt tgtaaaggga                                                   20


<210> 28180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28180
taaacaaaac attttgtaaa                                                   20


<210> 28181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28181
ataaacaaaa cattttgtaa                                                   20


<210> 28182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28182
tataaacaaa acattttgta                                                   20


<210> 28183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28183
atgtttttac aagaattttt                                                   20


<210> 28184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28184
tttatttccc atgtttttac                                                   20


<210> 28185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28185
accaattatt tctgggaggt                                                   20


<210> 28186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28186
tagcaccaat tatttctggg                                                   20


<210> 28187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28187
ttagcaccaa ttatttctgg                                                   20


<210> 28188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28188
tattagcacc aattatttct                                                   20


<210> 28189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28189
atattagcac caattatttc                                                   20


<210> 28190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28190
aaaaagaatg gaagaaatat                                                   20


<210> 28191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28191
catacatata aaaagaatgg                                                   20


<210> 28192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28192
atacatacat ataaaaagaa                                                   20


<210> 28193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28193
aaattataca tacatataaa                                                   20


<210> 28194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28194
taatgatgga ttaaataata                                                   20


<210> 28195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28195
aaaatctttt agaataatga                                                   20


<210> 28196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28196
tatcatgagg aaaaatcttt                                                   20


<210> 28197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28197
tttaaaatta ttttatcatg                                                   20


<210> 28198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28198
ttttaaaatt attttatcat                                                   20


<210> 28199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28199
cttaaagtat tattttgcca                                                   20


<210> 28200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28200
tatgaaaatt gtatatctta                                                   20


<210> 28201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28201
tggaaaatta gaaaataact                                                   20


<210> 28202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28202
aaatttaaat tttggaaaat                                                   20


<210> 28203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28203
atcagaaaaa atttaaattt                                                   20


<210> 28204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28204
attttaataa tggtaaaaat                                                   20


<210> 28205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28205
tcagtgcagc attttaataa                                                   20


<210> 28206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28206
tgatgcacaa atattcagtg                                                   20


<210> 28207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28207
aattctgatg cacaaatatt                                                   20


<210> 28208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28208
gagggcaatc atctgcaatg                                                   20


<210> 28209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28209
gagtctaatg tattagggga                                                   20


<210> 28210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28210
ggagtctaat gtattagggg                                                   20


<210> 28211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28211
aggagtctaa tgtattaggg                                                   20


<210> 28212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28212
caaggagtct aatgtattag                                                   20


<210> 28213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28213
tcaaggagtc taatgtatta                                                   20


<210> 28214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28214
ttcaaggagt ctaatgtatt                                                   20


<210> 28215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28215
cttcaaggag tctaatgtat                                                   20


<210> 28216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28216
cctagttaaa tctcttcaag                                                   20


<210> 28217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28217
cacctagtta aatctcttca                                                   20


<210> 28218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28218
tcacctagtt aaatctcttc                                                   20


<210> 28219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28219
atttgtctga aggtttcacc                                                   20


<210> 28220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28220
ttgccttaac atttgtctga                                                   20


<210> 28221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28221
gttgccttaa catttgtctg                                                   20


<210> 28222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28222
acataatttc aaatgtactg                                                   20


<210> 28223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28223
tttgagaagg cttgtactaa                                                   20


<210> 28224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28224
tgtttgagaa ggcttgtact                                                   20


<210> 28225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28225
ttcagtgtaa atgtttgaga                                                   20


<210> 28226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28226
cttcagtgta aatgtttgag                                                   20


<210> 28227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28227
attcttcagt gtaaatgttt                                                   20


<210> 28228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28228
ctctttccag agagattctt                                                   20


<210> 28229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28229
tccttaatcc tctttccaga                                                   20


<210> 28230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28230
cctccttaat cctctttcca                                                   20


<210> 28231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28231
ttcctcctta atcctctttc                                                   20


<210> 28232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28232
aggttgtcat agattctcga                                                   20


<210> 28233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28233
gtggctaatt taggttgtca                                                   20


<210> 28234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28234
aattttggtg tggctaattt                                                   20


<210> 28235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28235
taattttggt gtggctaatt                                                   20


<210> 28236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28236
ttaagaaaat aattttggtg                                                   20


<210> 28237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28237
agatattaag aaaataattt                                                   20


<210> 28238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28238
aagataaaac atgagatatt                                                   20


<210> 28239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28239
ggatttttaa gataaaacat                                                   20


<210> 28240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28240
ttaatgtcac aaggattttt                                                   20


<210> 28241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28241
catgttttgt taatgtcaca                                                   20


<210> 28242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28242
tcatgttttg ttaatgtcac                                                   20


<210> 28243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28243
tctatggggt atgactaaaa                                                   20


<210> 28244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28244
ttaacagata ctcttctatg                                                   20


<210> 28245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28245
attaacagat actcttctat                                                   20


<210> 28246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28246
aattaacaga tactcttcta                                                   20


<210> 28247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28247
tattttaacg ttaaaattaa                                                   20


<210> 28248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28248
agagtaccaa ttgtatacag                                                   20


<210> 28249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28249
cccagagtac caattgtata                                                   20


<210> 28250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28250
acacacaatg gatttcccca                                                   20


<210> 28251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28251
atacacacaa tggatttccc                                                   20


<210> 28252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28252
atatacacac atacacacaa                                                   20


<210> 28253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28253
aattgattaa ataatatagt                                                   20


<210> 28254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28254
gaataattga ttaaataata                                                   20


<210> 28255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28255
tatcatgagg aaaaatcttt                                                   20


<210> 28256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28256
ttttaaatta ttatatcatg                                                   20


<210> 28257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28257
tttttaaatt attatatcat                                                   20


<210> 28258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28258
tatatatata tataaacaca                                                   20


<210> 28259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28259
accttttacc tacaatgact                                                   20


<210> 28260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28260
actgcatgaa aagtgatcta                                                   20


<210> 28261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28261
cactgcatga aaagtgatct                                                   20


<210> 28262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28262
taatcatctc actgcatgaa                                                   20


<210> 28263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28263
gaaccaattc tgggctgagc                                                   20


<210> 28264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28264
aaaggaacca attctgggct                                                   20


<210> 28265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28265
tggaaaaagg aaccaattct                                                   20


<210> 28266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28266
gtggaaaaag gaaccaattc                                                   20


<210> 28267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28267
ctcatttctg gtgtggaaaa                                                   20


<210> 28268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28268
cctcatttct ggtgtggaaa                                                   20


<210> 28269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28269
ctgtatcctc atttctggtg                                                   20


<210> 28270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28270
ataaactgta tcctcatttc                                                   20


<210> 28271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28271
tatgcttggc cttctccagc                                                   20


<210> 28272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28272
ggtatatgct tggccttctc                                                   20


<210> 28273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28273
gaggctctgc ggtatatgct                                                   20


<210> 28274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 28274
cggttacaac agaggctctg                                                   20


<210> 28275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28275
aatgcaaacg gttacaacag                                                   20


<210> 28276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28276
aaatgcaaac ggttacaaca                                                   20


<210> 28277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28277
agaaatgcaa acggttacaa                                                   20


<210> 28278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 28278
cctagaggta gaaatgcaaa                                                   20


<210> 28279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28279
tttaaaattc ttcctagagg                                                   20


<210> 28280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28280
tgatttaaaa ttcttcctag                                                   20


<210> 28281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28281
ttgatttaaa attcttccta                                                   20


<210> 28282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28282
atttgattta aaattcttcc                                                   20


<210> 28283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28283
aaaagagcaa gaagaagctg                                                   20


<210> 28284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28284
aaaaagagca agaagaagct                                                   20


<210> 28285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28285
tcttaaaaaa gagcaagaag                                                   20


<210> 28286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28286
ccgtcttaaa aaagagcaag                                                   20


<210> 28287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28287
agaccgtctt aaaaaagagc                                                   20


<210> 28288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28288
tgttagaccg tcttaaaaaa                                                   20


<210> 28289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28289
gatgttagac cgtcttaaaa                                                   20


<210> 28290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28290
attagaattt caacagatgt                                                   20


<210> 28291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28291
agaaagaatt agaatttcaa                                                   20


<210> 28292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28292
agaagctaaa cagaaagaat                                                   20


<210> 28293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28293
cattgaagaa gctaaacaga                                                   20


<210> 28294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28294
caaacattga agaagctaaa                                                   20


<210> 28295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28295
gaaccaggca aacattgaag                                                   20


<210> 28296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28296
acagaaccag gcaaacattg                                                   20


<210> 28297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28297
ggcatatgaa gaacagaacc                                                   20


<210> 28298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28298
tggcatatga agaacagaac                                                   20


<210> 28299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28299
ttgccatggc atatgaagaa                                                   20


<210> 28300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28300
tgtggttgcc atggcatatg                                                   20


<210> 28301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28301
gatcctggct gtggttgcca                                                   20


<210> 28302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28302
aataaacttg atcctggctg                                                   20


<210> 28303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28303
ttatctaata aacttgatcc                                                   20


<210> 28304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28304
tttgtcgtag tgattttcct                                                   20


<210> 28305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28305
ctttgtcgta gtgattttcc                                                   20


<210> 28306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28306
ctacatgatc ttctttgtcg                                                   20


<210> 28307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28307
ccctagacgc tgcgtgctgc                                                   20


<210> 28308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28308
tgacaatttc catttttccc                                                   20


<210> 28309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28309
atgagattat accaaactgt                                                   20


<210> 28310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28310
ctttatattt ttgataacat                                                   20


<210> 28311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28311
tttaatattt gttttccatg                                                   20


<210> 28312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28312
atcttacatg actttagtac                                                   20


<210> 28313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28313
tcaagaatct tacatgactt                                                   20


<210> 28314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28314
tactactaca cttaataatc                                                   20


<210> 28315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28315
atgagtaatt ttcagactgt                                                   20


<210> 28316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28316
tatgagtaat tttcagactg                                                   20


<210> 28317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28317
ttaattttat gagtaatttt                                                   20


<210> 28318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28318
agcaaaggat ttaattttat                                                   20


<210> 28319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28319
taaaatttga aagtgagcaa                                                   20


<210> 28320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28320
ctaaaatttg aaagtgagca                                                   20


<210> 28321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28321
tgttcctaaa atttgaaagt                                                   20


<210> 28322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28322
cacctgttcc taaaatttga                                                   20


<210> 28323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28323
tttaacagta aaagggacta                                                   20


<210> 28324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28324
atagaatttt aacagtaaaa                                                   20


<210> 28325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28325
gatagaattt taacagtaaa                                                   20


<210> 28326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28326
agatagaatt ttaacagtaa                                                   20


<210> 28327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28327
aagaaaagat agaattttaa                                                   20


<210> 28328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28328
gatgataaag aaagaaaaga                                                   20


<210> 28329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28329
atttgatgat aaagaaagaa                                                   20


<210> 28330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28330
ttaatatttg atgataaaga                                                   20


<210> 28331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28331
attattaata tttgatgata                                                   20


<210> 28332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28332
attaaataag accatctgcc                                                   20


<210> 28333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28333
gatgaataaa gtaattaaat                                                   20


<210> 28334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28334
aaatacctat gagatgaata                                                   20


<210> 28335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28335
agttaattga aaatacctat                                                   20


<210> 28336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28336
agcaaagaaa gcgaaaaaaa                                                   20


<210> 28337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28337
tctattttaa aaagcaaaga                                                   20


<210> 28338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28338
aaattctatt ttaaaaagca                                                   20


<210> 28339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28339
aaaaaaaatt ctattttaaa                                                   20


<210> 28340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28340
aaaaaaaatc tctgtacctt                                                   20


<210> 28341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28341
tatgccaaaa aaaagaaaaa                                                   20


<210> 28342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28342
ctgcacgtta tgccaaaaaa                                                   20


<210> 28343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28343
atgggtgcag caaaccacca                                                   20


<210> 28344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28344
aggtaacagg ttgatgggtg                                                   20


<210> 28345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28345
aatgtaggta acaggttgat                                                   20


<210> 28346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28346
taatgtaggt aacaggttga                                                   20


<210> 28347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28347
acatacctaa tgtaggtaac                                                   20


<210> 28348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28348
gacataccta atgtaggtaa                                                   20


<210> 28349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28349
ttaggagaca tacctaatgt                                                   20


<210> 28350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28350
attaggagac atacctaatg                                                   20


<210> 28351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28351
aaagggagga atagcattag                                                   20


<210> 28352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28352
gcaaagggag gaatagcatt                                                   20


<210> 28353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28353
ggcaaaggga ggaatagcat                                                   20


<210> 28354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28354
gtggggggca aagggaggaa                                                   20


<210> 28355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28355
cggtggtggg gggcaaaggg                                                   20


<210> 28356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28356
tcggtggtgg ggggcaaagg                                                   20


<210> 28357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28357
tgtcggtggt ggggggcaaa                                                   20


<210> 28358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28358
ctgtcggtgg tggggggcaa                                                   20


<210> 28359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28359
cctgtcggtg gtggggggca                                                   20


<210> 28360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28360
tggggcctgt cggtggtggg                                                   20


<210> 28361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28361
ctggggcctg tcggtggtgg                                                   20


<210> 28362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28362
actggggcct gtcggtggtg                                                   20


<210> 28363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28363
cactggggcc tgtcggtggt                                                   20


<210> 28364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28364
acactggggc ctgtcggtgg                                                   20


<210> 28365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28365
cacacactgg ggcctgtcgg                                                   20


<210> 28366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 28366
catcacacac tggggcctgt                                                   20


<210> 28367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28367
gagaagatca tcacacactg                                                   20


<210> 28368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28368
tgagaagatc atcacacact                                                   20


<210> 28369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28369
atgagaagat catcacacac                                                   20


<210> 28370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28370
gagaacacat gggcaatgag                                                   20


<210> 28371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28371
aatgagaaca catgggcaat                                                   20


<210> 28372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28372
ggtgggcaat gagaacacat                                                   20


<210> 28373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28373
aggtgggcaa tgagaacaca                                                   20


<210> 28374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28374
atgagtgaga ggtgggcaat                                                   20


<210> 28375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28375
ctcactcatg agtgagaggt                                                   20


<210> 28376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28376
tctcactcat gagtgagagg                                                   20


<210> 28377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28377
tgttctcact catgagtgag                                                   20


<210> 28378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28378
atgttctcac tcatgagtga                                                   20


<210> 28379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28379
gcatgttctc actcatgagt                                                   20


<210> 28380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28380
caacgcatgt tctcactcat                                                   20


<210> 28381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28381
tcagcaaact aaaacaggaa                                                   20


<210> 28382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28382
cattctcagc aaactaaaac                                                   20


<210> 28383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28383
tcattctcag caaactaaaa                                                   20


<210> 28384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28384
aagctagaaa ccatcattct                                                   20


<210> 28385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28385
tgcagggaca tggatgaagc                                                   20


<210> 28386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28386
cctttgcagg gacatggatg                                                   20


<210> 28387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28387
tcatgtcctt tgcagggaca                                                   20


<210> 28388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28388
ataagttcat gtcctttgca                                                   20


<210> 28389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28389
aataagttca tgtcctttgc                                                   20


<210> 28390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28390
gaataagttc atgtcctttg                                                   20


<210> 28391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28391
atgcagccat aaaaaagaat                                                   20


<210> 28392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28392
aatactatgc agccataaaa                                                   20


<210> 28393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28393
atacaccatg gaatactatg                                                   20


<210> 28394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28394
aatgtggcac atatacacca                                                   20


<210> 28395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28395
tagactggat aaagaaaatg                                                   20


<210> 28396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28396
catcaatgat agactggata                                                   20


<210> 28397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28397
aatgcccatc aatgatagac                                                   20


<210> 28398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28398
acccaaatgc ccatcaatga                                                   20


<210> 28399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28399
tattcacaat agcaaagact                                                   20


<210> 28400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28400
ctattcacaa tagcaaagac                                                   20


<210> 28401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28401
tggcactatt cacaatagca                                                   20


<210> 28402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28402
tattgtggca ctattcacaa                                                   20


<210> 28403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28403
atgcacacat atgtttattg                                                   20


<210> 28404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28404
ttacatatca ttctatggta                                                   20


<210> 28405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28405
aaagattaca tatcattcta                                                   20


<210> 28406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28406
attactgggt atatacccaa                                                   20


<210> 28407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28407
gacccagcaa tcccattact                                                   20


<210> 28408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28408
tgacccagca atcccattac                                                   20


<210> 28409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28409
cagtgtggaa gacagtgacc                                                   20


<210> 28410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28410
agttcaacca gtgtggaaga                                                   20


<210> 28411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28411
aattagttca accagtgtgg                                                   20


<210> 28412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28412
gtaaattagt tcaaccagtg                                                   20


<210> 28413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28413
ggagtgtaaa ttagttcaac                                                   20


<210> 28414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28414
ctgttggtag gagtgtaaat                                                   20


<210> 28415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28415
tgcttttaaa ctgttggtag                                                   20


<210> 28416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28416
aatgctttta aactgttggt                                                   20


<210> 28417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28417
gaatgctttt aaactgttgg                                                   20


<210> 28418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28418
taggaatgct tttaaactgt                                                   20


<210> 28419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28419
tggagaaaat gtggagaaat                                                   20


<210> 28420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28420
ctggagaaaa tgtggagaaa                                                   20


<210> 28421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28421
cagatgctgg agaaaatgtg                                                   20


<210> 28422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28422
aacagatgct ggagaaaatg                                                   20


<210> 28423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28423
tcagaaaata acagatgctg                                                   20


<210> 28424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28424
agtcagaaaa taacagatgc                                                   20


<210> 28425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28425
attaaaaagt cagaaaataa                                                   20


<210> 28426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28426
aatggtgata attaaaaagt                                                   20


<210> 28427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28427
ttagaatggt gataattaaa                                                   20


<210> 28428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28428
ccatctcatg ccagttagaa                                                   20


<210> 28429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28429
agataccatc tcatgccagt                                                   20


<210> 28430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28430
aatgagatac catctcatgc                                                   20


<210> 28431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28431
atgcaattca aaaccacaat                                                   20


<210> 28432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28432
ctcatcatca ctggccatta                                                   20


<210> 28433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28433
agctcatcat cactggccat                                                   20


<210> 28434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28434
gaaaaaaagc tcatcatcac                                                   20


<210> 28435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28435
taacttaaac atatgaaaaa                                                   20


<210> 28436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28436
ataggtggag caaaccacca                                                   20


<210> 28437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28437
agataatggg ttgataggtg                                                   20


<210> 28438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28438
ctagataatg ggttgatagg                                                   20


<210> 28439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28439
aacctagata atgggttgat                                                   20


<210> 28440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28440
aaacctagat aatgggttga                                                   20


<210> 28441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28441
ggtcttaaaa cctagataat                                                   20


<210> 28442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28442
aggtcttaaa acctagataa                                                   20


<210> 28443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28443
tgcatgcagg tcttaaaacc                                                   20


<210> 28444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28444
gacaactacc taatgcatgc                                                   20


<210> 28445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28445
ggacaactac ctaatgcatg                                                   20


<210> 28446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28446
gcaaggggag ggagaacgtt                                                   20


<210> 28447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28447
ggcaagggga gggagaacgt                                                   20


<210> 28448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28448
gggtgggagg caaggggagg                                                   20


<210> 28449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28449
gggggtggga ggcaagggga                                                   20


<210> 28450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28450
ggggggtggg aggcaagggg                                                   20


<210> 28451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28451
tggggggtgg gaggcaaggg                                                   20


<210> 28452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28452
gttggggggt gggaggcaag                                                   20


<210> 28453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28453
tgttgggggg tgggaggcaa                                                   20


<210> 28454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28454
ctgttggggg gtgggaggca                                                   20


<210> 28455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28455
cctgttgggg ggtgggaggc                                                   20


<210> 28456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28456
ggggcctgtt ggggggtggg                                                   20


<210> 28457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28457
cggggcctgt tggggggtgg                                                   20


<210> 28458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28458
accggggcct gttggggggt                                                   20


<210> 28459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28459
caccggggcc tgttgggggg                                                   20


<210> 28460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28460
acacaccggg gcctgttggg                                                   20


<210> 28461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28461
cacacaccgg ggcctgttgg                                                   20


<210> 28462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28462
acacacaccg gggcctgttg                                                   20


<210> 28463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28463
aacacacacc ggggcctgtt                                                   20


<210> 28464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28464
caacacacac cggggcctgt                                                   20


<210> 28465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28465
gaggggaaca acacacaccg                                                   20


<210> 28466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28466
ggaggggaac aacacacacc                                                   20


<210> 28467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 28467
gggaggggaa caacacacac                                                   20


<210> 28468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28468
gaacacatgg acacagggag                                                   20


<210> 28469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28469
tgaacacatg gacacaggga                                                   20


<210> 28470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28470
ttgaacacat ggacacaggg                                                   20


<210> 28471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28471
tttgaacaca tggacacagg                                                   20


<210> 28472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28472
aatttgaaca catggacaca                                                   20


<210> 28473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28473
caatttgaac acatggacac                                                   20


<210> 28474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28474
acaatttgaa cacatggaca                                                   20


<210> 28475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28475
agttgaacaa tttgaacaca                                                   20


<210> 28476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28476
atgttctcac tcataagtgg                                                   20


<210> 28477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28477
gcatgttctc actcataagt                                                   20


<210> 28478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28478
tgcatgttct cactcataag                                                   20


<210> 28479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28479
cactgcatgt tctcactcat                                                   20


<210> 28480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28480
tcagcaaact aatacaggaa                                                   20


<210> 28481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28481
cctcagcaaa ctaatacagg                                                   20


<210> 28482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28482
catcctcagc aaactaatac                                                   20


<210> 28483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28483
tcatcctcag caaactaata                                                   20


<210> 28484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28484
aagctggaag ccatcatcct                                                   20


<210> 28485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28485
agggacatgg atgaagctgg                                                   20


<210> 28486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28486
tacagggaca tggatgaagc                                                   20


<210> 28487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28487
cctttacagg gacatggatg                                                   20


<210> 28488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28488
tcatgtcctt tacagggaca                                                   20


<210> 28489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28489
atgagatcat gtcctttaca                                                   20


<210> 28490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28490
aatgagatca tgtcctttac                                                   20


<210> 28491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28491
gaatgagatc atgtccttta                                                   20


<210> 28492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28492
tgcagccatt aaaaaagaat                                                   20


<210> 28493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28493
atactatgca gccattaaaa                                                   20


<210> 28494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28494
atacaccatg gaatactatg                                                   20


<210> 28495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28495
aatgtggtac atatacacca                                                   20


<210> 28496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28496
taaattgtat aaagaaaatg                                                   20


<210> 28497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28497
catcaatgtt aaattgtata                                                   20


<210> 28498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28498
tatttacaat agcaaagaga                                                   20


<210> 28499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28499
gtactattta caatagcaaa                                                   20


<210> 28500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28500
cagtactatt tacaatagca                                                   20


<210> 28501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28501
tattgcagta ctatttacaa                                                   20


<210> 28502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28502
atgcacacat atgtttattg                                                   20


<210> 28503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28503
atataaatca ttctactaca                                                   20


<210> 28504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28504
gacctagcaa tcccattact                                                   20


<210> 28505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28505
tgacctagca atcccattac                                                   20


<210> 28506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28506
accagaaata ccatttgacc                                                   20


<210> 28507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28507
attccttaag gacctagaac                                                   20


<210> 28508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28508
gaggcaattc cttaaggacc                                                   20


<210> 28509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28509
gacagtgagg caattcctta                                                   20


<210> 28510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28510
agacagtgag gcaattcctt                                                   20


<210> 28511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28511
caacaatttt gaagacagtg                                                   20


<210> 28512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28512
tcaacaattt tgaagacagt                                                   20


<210> 28513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28513
tagttcaaca attttgaaga                                                   20


<210> 28514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28514
aaattagttc aacaattttg                                                   20


<210> 28515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28515
ctgttggtgg gagtgtaaat                                                   20


<210> 28516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28516
cacttttaca ctgttggtgg                                                   20


<210> 28517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28517
agcactttta cactgttggt                                                   20


<210> 28518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28518
tagcactttt acactgttgg                                                   20


<210> 28519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28519
tagtagcact tttacactgt                                                   20


<210> 28520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28520
gtgaggctat gaagaaatag                                                   20


<210> 28521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28521
ctggtgaggc tatgaagaaa                                                   20


<210> 28522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28522
tagattctgg tgaggctatg                                                   20


<210> 28523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28523
agaaacaata gattctggtg                                                   20


<210> 28524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28524
gagaaacaat agattctggt                                                   20


<210> 28525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28525
agttgagaaa caatagattc                                                   20


<210> 28526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28526
attaaaaagt tgagaaacaa                                                   20


<210> 28527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28527
atggtgatta ttaaaaagtt                                                   20


<210> 28528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28528
tcagaatggt gattattaaa                                                   20


<210> 28529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28529
ccatctcaag tcagtcagaa                                                   20


<210> 28530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28530
agataccatc tcaagtcagt                                                   20


<210> 28531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28531
aatgagatac catctcaagt                                                   20


<210> 28532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28532
ccacaatgag ataccatctc                                                   20


<210> 28533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28533
acgcaaatca aaaccacaat                                                   20


<210> 28534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28534
gctcaacatc agtgatcatt                                                   20


<210> 28535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28535
catgaaaaaa agctcaacat                                                   20


<210> 28536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28536
cggccaaaaa acatgaaaaa                                                   20


<210> 28537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 28537
ctcaaaagaa gacatttatg                                                   20


<210> 28538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28538
gaacagagac ttctcaaaag                                                   20


<210> 28539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28539
tatgaacaga gacttctcaa                                                   20


<210> 28540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28540
gtgggcaaag gatatgaaca                                                   20


<210> 28541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28541
aagtgggcaa aggatatgaa                                                   20


<210> 28542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28542
tcccatcaaa aagtgggcaa                                                   20


<210> 28543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28543
atcccatcaa aaagtgggca                                                   20


<210> 28544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28544
cttgcatccc atcaaaaagt                                                   20


<210> 28545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28545
ccttgcatcc catcaaaaag                                                   20


<210> 28546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28546
cagccttgca tcccatcaaa                                                   20


<210> 28547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28547
ttgatttgca tatattgaac                                                   20


<210> 28548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28548
cattggttct gtttatgtga                                                   20


<210> 28549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28549
aatcatgtgg tttttgtcat                                                   20


<210> 28550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28550
catctattga gataatcatg                                                   20


<210> 28551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28551
agaccttctc tgcatctatt                                                   20


<210> 28552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28552
atggatgttg cattttattg                                                   20


<210> 28553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28553
ttgatagttt ttaacatgaa                                                   20


<210> 28554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28554
atcaatacct agtttattga                                                   20


<210> 28555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28555
agatatgttc catcaatacc                                                   20


<210> 28556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28556
taaatagctc ttattatttt                                                   20


<210> 28557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28557
ggctatggag ttttcataaa                                                   20


<210> 28558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28558
tcagtatgat attggctatg                                                   20


<210> 28559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28559
attcagtatg atattggcta                                                   20


<210> 28560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28560
tttcccattc agtatgatat                                                   20


<210> 28561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28561
gcttccagct ttttcccatt                                                   20


<210> 28562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28562
gtttttaaag ggaatgcttc                                                   20


<210> 28563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28563
gtcttgtgcc agtttttaaa                                                   20


<210> 28564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28564
tgtcttgtgc cagtttttaa                                                   20


<210> 28565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28565
ttgtcttgtg ccagttttta                                                   20


<210> 28566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28566
agggcatcct tgtcttgtgc                                                   20


<210> 28567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28567
tgaatagcag tggtgagaga                                                   20


<210> 28568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28568
ttgaatagca gtggtgagag                                                   20


<210> 28569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28569
attgaatagc agtggtgaga                                                   20


<210> 28570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28570
atattgaata gcagtggtga                                                   20


<210> 28571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28571
ctatattgaa tagcagtggt                                                   20


<210> 28572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28572
aacactatat tgaatagcag                                                   20


<210> 28573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28573
tccaacacta tattgaatag                                                   20


<210> 28574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28574
aattccaaca ctatattgaa                                                   20


<210> 28575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28575
tcttgtctga ttgccctggc                                                   20


<210> 28576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28576
tttctcttgt ctgattgccc                                                   20


<210> 28577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 28577
tgcagagaca atttgacttc                                                   20


<210> 28578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28578
atagaatcat gtcatttgca                                                   20


<210> 28579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28579
atatagaatc atgtcatttg                                                   20


<210> 28580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28580
atgatcgggt tttctaaata                                                   20


<210> 28581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28581
gttttggggc tgagatgatc                                                   20


<210> 28582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 28582
agttttgggg ctgagatgat                                                   20


<210> 28583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28583
gtttaaagag ttttggggct                                                   20


<210> 28584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28584
tatcagttta aagagttttg                                                   20


<210> 28585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28585
ttatcagttt aaagagtttt                                                   20


<210> 28586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28586
cttatcagtt taaagagttt                                                   20


<210> 28587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28587
aagttgctta tcagtttaaa                                                   20


<210> 28588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28588
tgaagttgct tatcagttta                                                   20


<210> 28589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28589
accttgctga agttgcttat                                                   20


<210> 28590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28590
tgtatcctga taccttgctg                                                   20


<210> 28591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28591
cttgtctatt gttggtgtat                                                   20


<210> 28592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28592
gcttgtctat tgttggtgta                                                   20


<210> 28593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28593
gctctctgct tgtctattgt                                                   20


<210> 28594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28594
atgggagttt attcatgatt                                                   20


<210> 28595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28595
tttatagcaa ttgcaaatgg                                                   20


<210> 28596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28596
tctttatagc aattgcaaat                                                   20


<210> 28597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28597
ctctttatag caattgcaaa                                                   20


<210> 28598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28598
taggtatttt attctcttta                                                   20


<210> 28599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28599
cctttgtaag ctgtattcct                                                   20


<210> 28600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28600
tcctttgtaa gctgtattcc                                                   20


<210> 28601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28601
aggtctttca tatcctttgt                                                   20


<210> 28602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28602
gtggcttgta gttcttgaag                                                   20


<210> 28603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28603
agtggcttgt agttcttgaa                                                   20


<210> 28604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28604
gtagtggctt gtagttcttg                                                   20


<210> 28605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28605
tttccttgag tagtggcttg                                                   20


<210> 28606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28606
tctcttgttt ccttgagtag                                                   20


<210> 28607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28607
tcctctcttg tttccttgag                                                   20


<210> 28608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28608
gtgtcctctc ttgtttcctt                                                   20


<210> 28609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28609
attcttccta tccatgagta                                                   20


<210> 28610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28610
cattgattct tcctatccat                                                   20


<210> 28611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28611
ataaattact ttcggcagta                                                   20


<210> 28612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28612
aatctataaa ttactttcgg                                                   20


<210> 28613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 28613
ttgaatctat aaattacttt                                                   20


<210> 28614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28614
caatggtaat ttgatgggac                                                   20


<210> 28615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28615
gatgtcaatg gtaatttgat                                                   20


<210> 28616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28616
agatgtcaat ggtaatttga                                                   20


<210> 28617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28617
taattctgtg aagatgtcaa                                                   20


<210> 28618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28618
agtagttttc taattctgtg                                                   20


<210> 28619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28619
gtttcatatg aaatttaaag                                                   20


<210> 28620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28620
ctggtttcat atgaaattta                                                   20


<210> 28621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28621
ttgctatatg tgctctttcc                                                   20


<210> 28622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28622
ccagctttgt tctttttgct                                                   20


<210> 28623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28623
gtcaggtagg ctgatgcctc                                                   20


<210> 28624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28624
agtatagttt gaagtcaggt                                                   20


<210> 28625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28625
tagtatagtt tgaagtcagg                                                   20


<210> 28626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28626
tcatagtata gtttgaagtc                                                   20


<210> 28627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28627
ctcatagtat agtttgaagt                                                   20


<210> 28628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28628
taacctcata gtatagtttg                                                   20


<210> 28629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28629
gttactgtaa cctcatagta                                                   20


<210> 28630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28630
ttttggttac tgtaacctca                                                   20


<210> 28631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28631
gtaccactac catgctgttt                                                   20


<210> 28632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28632
attggcctat atgtctgttt                                                   20


<210> 28633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28633
cattggccta tatgtctgtt                                                   20


<210> 28634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28634
aggtctctat tctattccat                                                   20


<210> 28635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28635
gaagtgtggt gttatttctg                                                   20


<210> 28636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28636
agaagtgtgg tgttatttct                                                   20


<210> 28637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28637
atcagatgct tgtagaagtg                                                   20


<210> 28638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28638
cgaagatcag atgcttgtag                                                   20


<210> 28639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28639
tgtcgaagat cagatgcttg                                                   20


<210> 28640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28640
ttgtcaggtt tgtcgaagat                                                   20


<210> 28641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28641
tgtttttgtc aggtttgtcg                                                   20


<210> 28642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28642
ccacattgct tgtttttgtc                                                   20


<210> 28643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28643
tccacattgc ttgtttttgt                                                   20


<210> 28644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28644
ccagcaccat ttattatata                                                   20


<210> 28645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28645
cccagcacca tttattatat                                                   20


<210> 28646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28646
ccccagcacc atttattata                                                   20


<210> 28647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28647
atatggctag ccagcttccc                                                   20


<210> 28648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28648
gttttctgca tatggctagc                                                   20


<210> 28649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28649
ttcagttttc tgcatatggc                                                   20


<210> 28650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28650
cagtttcagt tttctgcata                                                   20


<210> 28651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28651
gtaaggaagg agcccagttt                                                   20


<210> 28652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28652
taaggtgtaa ggaaggagcc                                                   20


<210> 28653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28653
ttgtataagg tgtaaggaag                                                   20


<210> 28654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28654
ttttgtataa ggtgtaagga                                                   20


<210> 28655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28655
tttttgtata aggtgtaagg                                                   20


<210> 28656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28656
taatttttgt ataaggtgta                                                   20


<210> 28657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28657
ttaatttttg tataaggtgt                                                   20


<210> 28658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28658
cttgagttaa tttttgtata                                                   20


<210> 28659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28659
tcttgagtta atttttgtat                                                   20


<210> 28660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28660
ttaagtcttt aatccatctt                                                   20


<210> 28661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28661
atggtttggg gttttacatt                                                   20


<210> 28662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28662
tctagggttt tcatggtttg                                                   20


<210> 28663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28663
ttctagggtt ttcatggttt                                                   20


<210> 28664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28664
cttctagggt tttcatggtt                                                   20


<210> 28665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28665
gttttcttct agggttttca                                                   20


<210> 28666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28666
gttgcctagg ttttcttcta                                                   20


<210> 28667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28667
tgttgcctag gttttcttct                                                   20


<210> 28668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28668
gtgttgccta ggttttcttc                                                   20


<210> 28669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28669
tttcctgaat ggtgttgcct                                                   20


<210> 28670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28670
atttcctgaa tggtgttgcc                                                   20


<210> 28671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28671
gcccatgcct atttcctgaa                                                   20


<210> 28672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28672
cttttggtat ttttgtcatg                                                   20


<210> 28673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28673
gctttggttg caattgcttt                                                   20


<210> 28674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28674
ccatttgtca attttggctt                                                   20


<210> 28675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28675
tatatcccat ttgtcaattt                                                   20


<210> 28676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28676
tgtgcagaag ctctttagtt                                                   20


<210> 28677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28677
tttgctgtgc agaagctctt                                                   20


<210> 28678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28678
tagtttcttt tgctgtgcag                                                   20


<210> 28679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28679
tgttagtttc ttttgctgtg                                                   20


<210> 28680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28680
ttgcctgttc actctgatgt                                                   20


<210> 28681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28681
caaatttttc tcccattcta                                                   20


<210> 28682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28682
ttagaccttt gtcagatggg                                                   20


<210> 28683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28683
atattagacc tttgtcagat                                                   20


<210> 28684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28684
aatattagac ctttgtcaga                                                   20


<210> 28685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28685
tcttaatatt agacctttgt                                                   20


<210> 28686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28686
tacttgtaga ttcttaatat                                                   20


<210> 28687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28687
aaatttgttt aagttacttg                                                   20


<210> 28688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28688
attatcttat aaatttgttt                                                   20


<210> 28689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28689
ttacattata caattattaa                                                   20


<210> 28690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28690
taaaatgctt tgtatgataa                                                   20


<210> 28691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28691
acttattttt catttaatat                                                   20


<210> 28692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28692
aataattttt catcagaggt                                                   20


<210> 28693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28693
ttaaaataat ttttcatcag                                                   20


<210> 28694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28694
attaaaataa tttttcatca                                                   20


<210> 28695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28695
aaattaaaat aatttttcat                                                   20


<210> 28696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28696
gtcaccttta ctcaaaatta                                                   20


<210> 28697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28697
ttttttaaat atgcaagaag                                                   20


<210> 28698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28698
atatttttta aatatgcaag                                                   20


<210> 28699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28699
caaatatttt ttaaatatgc                                                   20


<210> 28700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28700
atgcacttta cagcaaaaat                                                   20


<210> 28701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28701
gatgcacttt acagcaaaaa                                                   20


<210> 28702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28702
attatgtaag atgcacttta                                                   20


<210> 28703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28703
aatgaattcg gaaattatgt                                                   20


<210> 28704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 28704
gagaatatta taaatgaatt                                                   20


<210> 28705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28705
tttatattta ctttatttcc                                                   20


<210> 28706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28706
atctgttttt ttttcttttt                                                   20


<210> 28707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28707
cacttttctc agaatagctg                                                   20


<210> 28708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28708
atgattcact tttctcagaa                                                   20


<210> 28709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28709
taacaatgat tcacttttct                                                   20


<210> 28710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28710
agaccaaaat gattattcta                                                   20


<210> 28711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28711
gcagccaagc caaaaggaag                                                   20


<210> 28712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28712
cagcagccaa gccaaaagga                                                   20


<210> 28713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28713
tcagcagcca agccaaaagg                                                   20


<210> 28714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28714
gtctcagcag ccaagccaaa                                                   20


<210> 28715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28715
agtctcagca gccaagccaa                                                   20


<210> 28716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28716
cttgtatagt ctcagcagcc                                                   20


<210> 28717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28717
atttacttgt atagtctcag                                                   20


<210> 28718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28718
tccatttact tgtatagtct                                                   20


<210> 28719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28719
gtggtctcca tttacttgta                                                   20


<210> 28720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28720
atgtgaacct cttggggctg                                                   20


<210> 28721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28721
acttgaatgt gaacctcttg                                                   20


<210> 28722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28722
aacttgaatg tgaacctctt                                                   20


<210> 28723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28723
taacttgaat gtgaacctct                                                   20


<210> 28724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28724
attgcaagtg gtaattcatg                                                   20


<210> 28725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28725
ttgatctctt gtattgcaag                                                   20


<210> 28726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28726
tcattgatct cttgtattgc                                                   20


<210> 28727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28727
aaatcaattg ctcccaactg                                                   20


<210> 28728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28728
aagatgcaat tcatttctct                                                   20


<210> 28729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28729
tgaactccta tttaaagtta                                                   20


<210> 28730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28730
tatttttgaa ctcctattta                                                   20


<210> 28731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28731
tgggatggcc tgaagagaag                                                   20


<210> 28732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28732
ttgggatggc ctgaagagaa                                                   20


<210> 28733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28733
gcttgggatg gcctgaagag                                                   20


<210> 28734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28734
cgtgcttggg atggcctgaa                                                   20


<210> 28735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28735
tgcgtgcttg ggatggcctg                                                   20


<210> 28736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28736
ttttccatgc gtgcttggga                                                   20


<210> 28737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28737
actgttttcc atgcgtgctt                                                   20


<210> 28738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28738
gactgttttc catgcgtgct                                                   20


<210> 28739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28739
tctcaagctg ctcctgcaca                                                   20


<210> 28740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28740
acatactgta atgttttctc                                                   20


<210> 28741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28741
tggggtccta gttaagtacc                                                   20


<210> 28742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28742
atggggtcct agttaagtac                                                   20


<210> 28743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28743
catcccatgg ggtcctagtt                                                   20


<210> 28744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28744
tatatcatcc catggggtcc                                                   20


<210> 28745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28745
cctgagtata tcatcccatg                                                   20


<210> 28746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28746
tcctgagtat atcatcccat                                                   20


<210> 28747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28747
ttcctgagta tatcatccca                                                   20


<210> 28748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28748
tctagatctc tcgccttcct                                                   20


<210> 28749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28749
ttctgggcat atttaatctc                                                   20


<210> 28750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28750
ataattttct tatcttttct                                                   20


<210> 28751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28751
aataattttc ttatcttttc                                                   20


<210> 28752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28752
cccatcacta ataatatggg                                                   20


<210> 28753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28753
actcccatca ctaataatat                                                   20


<210> 28754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28754
tactcccatc actaataata                                                   20


<210> 28755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28755
tatcttatta ccaaaattat                                                   20


<210> 28756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28756
ttttatttat ttgagaatgg                                                   20


<210> 28757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28757
tttttattta tttgagaatg                                                   20


<210> 28758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28758
gttttttatt tatttgagaa                                                   20


<210> 28759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28759
aggaggtttt ttatttattt                                                   20


<210> 28760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28760
tgttaagagc ctgtattagg                                                   20


<210> 28761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28761
atgttaagag cctgtattag                                                   20


<210> 28762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28762
gtatgttaag agcctgtatt                                                   20


<210> 28763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28763
tgtatgttaa gagcctgtat                                                   20


<210> 28764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28764
atgtacctgg tgtatgttaa                                                   20


<210> 28765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28765
atatgtacct ggtgtatgtt                                                   20


<210> 28766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28766
ttttgaatgg catatgtacc                                                   20


<210> 28767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28767
acatgcattg tatttttgaa                                                   20


<210> 28768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28768
taccaacagg tgagtaccaa                                                   20


<210> 28769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28769
tttaccaaca ggtgagtacc                                                   20


<210> 28770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28770
gaaaaccttt accaacaggt                                                   20


<210> 28771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28771
ctgggaaaac ctttaccaac                                                   20


<210> 28772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28772
actgggaaaa cctttaccaa                                                   20


<210> 28773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28773
gctaatgacc caagattact                                                   20


<210> 28774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28774
ggctaatgac ccaagattac                                                   20


<210> 28775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28775
cttgtttagg ctaatgaccc                                                   20


<210> 28776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28776
gggccttctt agccttgttt                                                   20


<210> 28777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28777
tgggccttct tagccttgtt                                                   20


<210> 28778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28778
cactttcagc tgggccttct                                                   20


<210> 28779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28779
gagctttgac actttcagct                                                   20


<210> 28780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28780
cgagctttga cactttcagc                                                   20


<210> 28781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28781
tacacgagct ttgacacttt                                                   20


<210> 28782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28782
aaccctgatt atggctacac                                                   20


<210> 28783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28783
attggcagaa accctgatta                                                   20


<210> 28784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28784
tacacctgtg tgaaaattgg                                                   20


<210> 28785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28785
gggtacacct gtgtgaaaat                                                   20


<210> 28786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28786
tgtgtagtca gtgtccagag                                                   20


<210> 28787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28787
gtgtgtagtc agtgtccaga                                                   20


<210> 28788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28788
cgtgtgtagt cagtgtccag                                                   20


<210> 28789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28789
tcgtgtgtag tcagtgtcca                                                   20


<210> 28790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28790
tctcgtgtgt agtcagtgtc                                                   20


<210> 28791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28791
tgttctttct cgtgtgtagt                                                   20


<210> 28792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28792
ataatgttct ttctcgtgtg                                                   20


<210> 28793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28793
gctatttagc ttgtgtcctg                                                   20


<210> 28794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28794
aacttttcag taaggctatt                                                   20


<210> 28795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28795
gagtttgtaa cttttcagta                                                   20


<210> 28796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28796
tgagtttgta acttttcagt                                                   20


<210> 28797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28797
accttgagtt tgtaactttt                                                   20


<210> 28798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28798
ccccctatag aagaaacctt                                                   20


<210> 28799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28799
tcaatattgt ccccctatag                                                   20


<210> 28800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28800
tattcaatat tgtcccccta                                                   20


<210> 28801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28801
taaagtcact aagtagtcag                                                   20


<210> 28802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28802
tggtaaagtc actaagtagt                                                   20


<210> 28803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28803
aatttggtaa agtcactaag                                                   20


<210> 28804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28804
aagaatttgg taaagtcact                                                   20


<210> 28805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28805
atgccttgaa gaatttggta                                                   20


<210> 28806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28806
gacttatgcc ttgaagaatt                                                   20


<210> 28807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28807
acagacagac ttatgccttg                                                   20


<210> 28808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28808
tattatccta ttttcacaga                                                   20


<210> 28809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28809
atgttattat cctattttca                                                   20


<210> 28810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28810
caagtcttat tttcttgagg                                                   20


<210> 28811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28811
ttacaagtct tattttcttg                                                   20


<210> 28812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28812
attacaagtc ttattttctt                                                   20


<210> 28813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28813
atcttattta aacttattac                                                   20


<210> 28814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28814
ctatgtgcag gatgtaagct                                                   20


<210> 28815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28815
actttctatg tgcaggatgt                                                   20


<210> 28816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28816
attaaacact ttctatgtgc                                                   20


<210> 28817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28817
tattaaacac tttctatgtg                                                   20


<210> 28818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28818
aatgatgatg atgctaatgg                                                   20


<210> 28819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28819
tttaatgatg atgatgctaa                                                   20


<210> 28820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28820
atatcaatat ttactgaacc                                                   20


<210> 28821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28821
gacagaaaga gctttggtaa                                                   20


<210> 28822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28822
tatacagaca gaaagagctt                                                   20


<210> 28823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28823
aagaattata cagacagaaa                                                   20


<210> 28824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28824
ccaagaatta tacagacaga                                                   20


<210> 28825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28825
tattccaaga attatacaga                                                   20


<210> 28826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28826
aatctattcc aagaattata                                                   20


<210> 28827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28827
tattgactct aatctattcc                                                   20


<210> 28828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28828
gctgcacatt tttatgaact                                                   20


<210> 28829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28829
ttagaaagaa aaaagtctta                                                   20


<210> 28830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28830
caccaatttt agaaagaaaa                                                   20


<210> 28831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28831
accagtccac caattttaga                                                   20


<210> 28832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28832
aaaaaccagt ccaccaattt                                                   20


<210> 28833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28833
ttaatggcat caggaaaaac                                                   20


<210> 28834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28834
tgtatttatt taatggcatc                                                   20


<210> 28835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28835
ttgtatttat ttaatggcat                                                   20


<210> 28836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28836
agaatattgt atttatttaa                                                   20


<210> 28837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28837
tgctgttccc agaagaatct                                                   20


<210> 28838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28838
gataaggttg ctgttcccag                                                   20


<210> 28839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28839
ctggataagg ttgctgttcc                                                   20


<210> 28840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28840
acataggaat aaactggata                                                   20


<210> 28841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28841
aacataggaa taaactggat                                                   20


<210> 28842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28842
ctggcaacat aggaataaac                                                   20


<210> 28843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28843
tctgtgtaca ctggcaacat                                                   20


<210> 28844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28844
ctctgtgtac actggcaaca                                                   20


<210> 28845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28845
tcatcaggct ctgtgtacac                                                   20


<210> 28846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28846
tatgcagaca tctattcatc                                                   20


<210> 28847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28847
ctatgcagac atctattcat                                                   20


<210> 28848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28848
ctcttgcttt tccccctatg                                                   20


<210> 28849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28849
ttttgtagca tcagctgcat                                                   20


<210> 28850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28850
ccaacttcat tttgtagcat                                                   20


<210> 28851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28851
cttacaccaa cttcattttg                                                   20


<210> 28852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28852
tttaagaata ttgtatatat                                                   20


<210> 28853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28853
gacttgggta cacatatttt                                                   20


<210> 28854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28854
caaagggatt ccttggactt                                                   20


<210> 28855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28855
gcaaagggat tccttggact                                                   20


<210> 28856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28856
ctctaagcaa agggattcct                                                   20


<210> 28857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28857
ttttggccac tctaagcaaa                                                   20


<210> 28858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28858
gttttggcca ctctaagcaa                                                   20


<210> 28859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28859
tgttttggcc actctaagca                                                   20


<210> 28860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28860
tgtcatgttt tggccactct                                                   20


<210> 28861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28861
ggtgactgaa tgtcatgttt                                                   20


<210> 28862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28862
tccaattaaa tgtgactcat                                                   20


<210> 28863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28863
ctccaattaa atgtgactca                                                   20


<210> 28864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28864
ctatttttct ttctactccc                                                   20


<210> 28865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28865
ctggaaaacg aagagtcaca                                                   20


<210> 28866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28866
tcttctttct ggaaaacgaa                                                   20


<210> 28867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28867
ggtcttcttt ctggaaaacg                                                   20


<210> 28868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28868
ataatttcag gtcttctttc                                                   20


<210> 28869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28869
aaagttggtt ggataatttc                                                   20


<210> 28870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28870
aaaagttggt tggataattt                                                   20


<210> 28871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28871
aaactccacc aaaagttggt                                                   20


<210> 28872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28872
tagaaaactc caccaaaagt                                                   20


<210> 28873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28873
cttctagaaa actccaccaa                                                   20


<210> 28874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28874
aaggtagaaa atgttacttc                                                   20


<210> 28875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28875
tcatataaat cttaagaagg                                                   20


<210> 28876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28876
aagtcatata aatcttaaga                                                   20


<210> 28877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28877
gaagtcatat aaatcttaag                                                   20


<210> 28878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28878
acagaagtca tataaatctt                                                   20


<210> 28879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28879
ctcgaattaa cacaagacag                                                   20


<210> 28880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28880
gtgctcgaat taacacaaga                                                   20


<210> 28881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28881
gacagtgctc gaattaacac                                                   20


<210> 28882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28882
ttgaaagcaa gactttgaga                                                   20


<210> 28883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28883
actcttgaaa gcaagacttt                                                   20


<210> 28884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28884
taatgcatac tcttgaaagc                                                   20


<210> 28885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28885
cagttaatgc atactcttga                                                   20


<210> 28886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28886
tccagtcttt aaaatgttca                                                   20


<210> 28887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28887
attctgtccc acagcaaatc                                                   20


<210> 28888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28888
atttgactca ttctgtccca                                                   20


<210> 28889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28889
attgcttttt atatatttca                                                   20


<210> 28890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28890
tgttcagtca gtttgcaaat                                                   20


<210> 28891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28891
gaaggaaaag aatgttcagt                                                   20


<210> 28892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28892
aagagaagga aaagaatgtt                                                   20


<210> 28893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28893
aaaggctgaa agagaaggaa                                                   20


<210> 28894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28894
agtctaaagg ctgaaagaga                                                   20


<210> 28895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28895
tagtctaaag gctgaaagag                                                   20


<210> 28896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28896
ttttagtcta aaggctgaaa                                                   20


<210> 28897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28897
ctttttagtc taaaggctga                                                   20


<210> 28898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28898
ttgttttctt tttagtctaa                                                   20


<210> 28899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28899
tttgttttct ttttagtcta                                                   20


<210> 28900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28900
tgtaatattt gttttctttt                                                   20


<210> 28901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28901
gtggtttcag cacagattca                                                   20


<210> 28902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28902
tgtggtttca gcacagattc                                                   20


<210> 28903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28903
ttgtggtttc agcacagatt                                                   20


<210> 28904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28904
tctcctttgt ggtttcagca                                                   20


<210> 28905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28905
gatgctctcc tttgtggttt                                                   20


<210> 28906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28906
tccaaagatg ctctcctttg                                                   20


<210> 28907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28907
ttattacttg gaaggatcca                                                   20


<210> 28908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28908
gaatattttt attacttgga                                                   20


<210> 28909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28909
agaatatttt tattacttgg                                                   20


<210> 28910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28910
aacagaatat ttttattact                                                   20


<210> 28911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28911
ctgttcaaat tcttcttcaa                                                   20


<210> 28912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28912
tttatcacaa tcacagatta                                                   20


<210> 28913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28913
tacctccttt atcacaatca                                                   20


<210> 28914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28914
tgggaccagg cctgaatttg                                                   20


<210> 28915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28915
gatgcatatt gcctgggacc                                                   20


<210> 28916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28916
ggatgcatat tgcctgggac                                                   20


<210> 28917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28917
taaatggatg catattgcct                                                   20


<210> 28918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28918
ataaatggat gcatattgcc                                                   20


<210> 28919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28919
atgagaaaat agtaaataaa                                                   20


<210> 28920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28920
agggagaata tatgagaaaa                                                   20


<210> 28921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28921
atatttgagg gagaatatat                                                   20


<210> 28922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28922
ttatcaataa atatttgagg                                                   20


<210> 28923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28923
gattatcaat aaatatttga                                                   20


<210> 28924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28924
agattatcaa taaatatttg                                                   20


<210> 28925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28925
gagattatca ataaatattt                                                   20


<210> 28926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28926
gtttattgcc tagcctctaa                                                   20


<210> 28927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28927
atgtttattg cctagcctct                                                   20


<210> 28928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28928
ttattgtcat gtttattgcc                                                   20


<210> 28929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28929
ccctcaccta aacataaagg                                                   20


<210> 28930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28930
accctcacct aaacataaag                                                   20


<210> 28931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28931
ccaccctcac ctaaacataa                                                   20


<210> 28932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28932
tccaccctca cctaaacata                                                   20


<210> 28933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28933
ttgccttaat ttattttctt                                                   20


<210> 28934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28934
agaaagaccg tccctgactg                                                   20


<210> 28935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28935
ttaaatatca tctccttaga                                                   20


<210> 28936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28936
tagtttaaat atcatctcct                                                   20


<210> 28937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28937
tctttgtcac acttaggtct                                                   20


<210> 28938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28938
ctgtcttctt tgtcacactt                                                   20


<210> 28939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28939
gctgtcttct ttgtcacact                                                   20


<210> 28940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28940
tctcttcacc agtattttca                                                   20


<210> 28941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28941
cagcccaaat atctcttcac                                                   20


<210> 28942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28942
tttagttctt tctcttcccc                                                   20


<210> 28943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28943
tcatctctgc cttagggctt                                                   20


<210> 28944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 28944
ccaacttcat ctctgcctta                                                   20


<210> 28945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28945
accaacttca tctctgcctt                                                   20


<210> 28946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28946
caccaacttc atctctgcct                                                   20


<210> 28947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28947
agccacactg gccatcttgc                                                   20


<210> 28948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28948
tcaccacact gtagccacac                                                   20


<210> 28949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28949
tcctccctct caccacactg                                                   20


<210> 28950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 28950
atgcaaattc cgacatgatc                                                   20


<210> 28951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28951
cagaatgtat cacagtcatt                                                   20


<210> 28952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28952
gcatttctca gaatgtatca                                                   20


<210> 28953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28953
cgtcctaatg atgcatttct                                                   20


<210> 28954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28954
caccctagga tgtttgcaca                                                   20


<210> 28955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28955
gcaccctagg atgtttgcac                                                   20


<210> 28956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28956
ggtttgtata agtgcaccct                                                   20


<210> 28957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28957
aggtttgtat aagtgcaccc                                                   20


<210> 28958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28958
tataccatct aggtttgtat                                                   20


<210> 28959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28959
tatggtagcc tataccatct                                                   20


<210> 28960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28960
gtatggtagc ctataccatc                                                   20


<210> 28961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28961
cacatagcct aggtgtatgg                                                   20


<210> 28962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28962
taccacatag cctaggtgta                                                   20


<210> 28963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28963
taggctatac cacatagcct                                                   20


<210> 28964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28964
ataggctata ccacatagcc                                                   20


<210> 28965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28965
gagcaatagg ctataccaca                                                   20


<210> 28966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28966
gtttgcagcc caggagcaat                                                   20


<210> 28967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28967
ggtttgcagc ccaggagcaa                                                   20


<210> 28968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28968
tctacaggtt tgcagcccag                                                   20


<210> 28969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28969
actctacagg tttgcagccc                                                   20


<210> 28970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28970
cactctacag gtttgcagcc                                                   20


<210> 28971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28971
tagcccactc tacaggtttg                                                   20


<210> 28972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28972
agtacagtag cccactctac                                                   20


<210> 28973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28973
gagtacagta gcccactcta                                                   20


<210> 28974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28974
gcctacaata ttgagtacag                                                   20


<210> 28975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28975
gttgcctaca atattgagta                                                   20


<210> 28976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28976
taacagttgc ctacaatatt                                                   20


<210> 28977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 28977
acacactttc cattgtataa                                                   20


<210> 28978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28978
tactgtacct tttctgtctt                                                   20


<210> 28979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28979
atatataatg gtgatctcat                                                   20


<210> 28980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28980
atagcggacc atatatataa                                                   20


<210> 28981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 28981
aaggatgttt tagtcaatag                                                   20


<210> 28982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28982
cataaggatg ttttagtcaa                                                   20


<210> 28983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28983
tgtaccacat aaggatgttt                                                   20


<210> 28984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28984
ccggagtatt gtaccacata                                                   20


<210> 28985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28985
tccggagtat tgtaccacat                                                   20


<210> 28986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28986
tactgagtct gcctcttccg                                                   20


<210> 28987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 28987
cttactgagt ctgcctcttc                                                   20


<210> 28988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 28988
acttatgtta ctgccttact                                                   20


<210> 28989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28989
aatgaaaagt aagataattt                                                   20


<210> 28990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28990
tggactggtg aatgaaaagt                                                   20


<210> 28991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28991
agtatggact ggtgaatgaa                                                   20


<210> 28992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28992
ggtcctaagt aagtatggac                                                   20


<210> 28993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 28993
tagtaggtcc taagtaagta                                                   20


<210> 28994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28994
agaattagta ggtcctaagt                                                   20


<210> 28995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 28995
acctagaatt agtaggtcct                                                   20


<210> 28996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 28996
cctcaacacc tagaattagt                                                   20


<210> 28997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28997
tcctcaacac ctagaattag                                                   20


<210> 28998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28998
atctcctcaa cacctagaat                                                   20


<210> 28999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 28999
attgtcatct cctcaacacc                                                   20


<210> 29000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29000
ataccatgaa aggtgaaaca                                                   20


<210> 29001
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29001
agcacaaaga ataccatgaa                                                   20


<210> 29002
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29002
tagcacaaag aataccatga                                                   20


<210> 29003
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29003
tactactaaa aattagcaca                                                   20


<210> 29004
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29004
gaacttttac tactaaaaat                                                   20


<210> 29005
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29005
caaatgacag aagagttgat                                                   20


<210> 29006
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29006
cttaacagca aatgacagaa                                                   20


<210> 29007
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29007
gccttaacag caaatgacag                                                   20


<210> 29008
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29008
caagccttaa cagcaaatga                                                   20


<210> 29009
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29009
gtcttaggaa caagccttaa                                                   20


<210> 29010
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29010
ctgcccccag tcttaggaac                                                   20


<210> 29011
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29011
atagatctgc ccccagtctt                                                   20


<210> 29012
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29012
gatagatctg cccccagtct                                                   20


<210> 29013
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29013
tacaaggata gatctgcccc                                                   20


<210> 29014
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29014
aaacatttac tatacaagga                                                   20


<210> 29015
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29015
atttaaacat ttactataca                                                   20


<210> 29016
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29016
catttaaaca tttactatac                                                   20


<210> 29017
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29017
agagatgaca aaaggttttt                                                   20


<210> 29018
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29018
tatttaagag agatgacaaa                                                   20


<210> 29019
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29019
atatttaaga gagatgacaa                                                   20


<210> 29020
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29020
agtagaatag atatttaaga                                                   20


<210> 29021
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29021
atagtagaat agatatttaa                                                   20


<210> 29022
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29022
ttatagtaga atagatattt                                                   20


<210> 29023
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29023
gtcaggttct tatagtagaa                                                   20


<210> 29024
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29024
aggaagtcag gttcttatag                                                   20


<210> 29025
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29025
aataggaagt caggttctta                                                   20


<210> 29026
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29026
cctgagtaaa ataggaagtc                                                   20


<210> 29027
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29027
acctgagtaa aataggaagt                                                   20


<210> 29028
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29028
tttgacctga gtaaaatagg                                                   20


<210> 29029
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29029
taatttgacc tgagtaaaat                                                   20


<210> 29030
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29030
ttaatttgac ctgagtaaaa                                                   20


<210> 29031
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29031
cagatttttt aatttgacct                                                   20


<210> 29032
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29032
tccaaaagtc tcccaataat                                                   20


<210> 29033
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29033
ttcttccatg attactccaa                                                   20


<210> 29034
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29034
tccaagaata tctgatttca                                                   20


<210> 29035
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29035
tagaagcaac attcaaatcc                                                   20


<210> 29036
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29036
acttacttaa gaagggatag                                                   20


<210> 29037
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29037
ttcacttact taagaaggga                                                   20


<210> 29038
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29038
ataattcact tacttaagaa                                                   20


<210> 29039
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29039
gataattcac ttacttaaga                                                   20


<210> 29040
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29040
agataattca cttacttaag                                                   20


<210> 29041
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29041
taaagataat tcacttactt                                                   20


<210> 29042
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29042
agctaaggct taatggctta                                                   20


<210> 29043
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29043
atgcagcagc taaggcttaa                                                   20


<210> 29044
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29044
ttttacagat gcagcagcta                                                   20


<210> 29045
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29045
attttacaga tgcagcagct                                                   20


<210> 29046
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29046
tacgtatttt acagatgcag                                                   20


<210> 29047
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29047
ttatacgtat tttacagatg                                                   20


<210> 29048
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29048
gtattcttat acgtatttta                                                   20


<210> 29049
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29049
atttaacaac tttataaagt                                                   20


<210> 29050
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29050
tatttaacaa ctttataaag                                                   20


<210> 29051
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29051
tactatttaa caactttata                                                   20


<210> 29052
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29052
gtgtggatca cagtatcaag                                                   20


<210> 29053
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29053
aatgtgtgga tcacagtatc                                                   20


<210> 29054
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29054
agtacagaat gtgtggatca                                                   20


<210> 29055
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29055
agcagctagt acagaatgtg                                                   20


<210> 29056
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29056
ctgtttttga gcagctagta                                                   20


<210> 29057
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29057
aactcctgtt tttgagcagc                                                   20


<210> 29058
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29058
taataactcc tgtttttgag                                                   20


<210> 29059
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29059
ttataataac tcctgttttt                                                   20


<210> 29060
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29060
ttttatctca aattgtataa                                                   20


<210> 29061
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29061
atgatgtgta attcaatcaa                                                   20


<210> 29062
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29062
tttatctgtg tcttctaagt                                                   20


<210> 29063
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29063
ttgttttatc tgtgtcttct                                                   20


<210> 29064
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29064
catttgcacc tcaaactgca                                                   20


<210> 29065
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29065
acatttgcac ctcaaactgc                                                   20


<210> 29066
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29066
gttcaggagt gttttcagga                                                   20


<210> 29067
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29067
cgaggttcag gagtgttttc                                                   20


<210> 29068
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29068
ccgaggttca ggagtgtttt                                                   20


<210> 29069
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29069
ccatccttcc cgaggttcag                                                   20


<210> 29070
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29070
gcccatcctt cccgaggttc                                                   20


<210> 29071
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29071
ggcccatcct tcccgaggtt                                                   20


<210> 29072
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29072
taccaggccc atccttcccg                                                   20


<210> 29073
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29073
ctaccaggcc catccttccc                                                   20


<210> 29074
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29074
tctcccatac tcactctacc                                                   20


<210> 29075
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29075
ctctcccata ctcactctac                                                   20


<210> 29076
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29076
ccatccttat taaaatattt                                                   20


<210> 29077
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29077
tagtttaaag gataattcta                                                   20


<210> 29078
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29078
gtgaaccagc attagtttaa                                                   20


<210> 29079
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29079
tgtgaaccag cattagttta                                                   20


<210> 29080
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29080
tgataaatgt gaaccagcat                                                   20


<210> 29081
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29081
agtggttgat aaatgtgaac                                                   20


<210> 29082
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29082
catataattc agctcctcag                                                   20


<210> 29083
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29083
attcatataa ttcagctcct                                                   20


<210> 29084
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29084
cagagcccat tcatataatt                                                   20


<210> 29085
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29085
tgtgctaata gacagctcca                                                   20


<210> 29086
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29086
agtgtgctaa tagacagctc                                                   20


<210> 29087
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29087
tatagcagtg tgctaataga                                                   20


<210> 29088
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29088
gtagtatagc agtgtgctaa                                                   20


<210> 29089
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29089
tgttaaatac agtagtatag                                                   20


<210> 29090
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29090
ctgtgttaaa tacagtagta                                                   20


<210> 29091
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29091
ttatactgtg ttaaatacag                                                   20


<210> 29092
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29092
ttcttatact gtgttaaata                                                   20


<210> 29093
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29093
gttttctaca aacctagagt                                                   20


<210> 29094
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29094
taaagttttc tacaaaccta                                                   20


<210> 29095
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29095
tgtaaagttt tctacaaacc                                                   20


<210> 29096
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29096
gttgtttaga aattattgta                                                   20


<210> 29097
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29097
taatttaatg tctagttgtt                                                   20


<210> 29098
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29098
catcttaata atttaatgtc                                                   20


<210> 29099
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29099
gttaacctta aatcttcttg                                                   20


<210> 29100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29100
tcaatttttt cccattttta                                                   20


<210> 29101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29101
tcccactttt gaatatgcac                                                   20


<210> 29102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29102
gtgattcatt ctttatcttt                                                   20


<210> 29103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 29103
caggcgtgag ccactgcgcc                                                   20


<210> 29104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29104
agtgctggca ttacaggcgt                                                   20


<210> 29105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29105
tcccaaagtg ctggcattac                                                   20


<210> 29106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29106
ctcccaaagt gctggcatta                                                   20


<210> 29107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29107
gcctcgacct cccaaagtgc                                                   20


<210> 29108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29108
ctgcccgcct cgacctccca                                                   20


<210> 29109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29109
tttcattgtg ttagccagga                                                   20


<210> 29110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29110
ggggtttcat tgtgttagcc                                                   20


<210> 29111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29111
cggggtttca ttgtgttagc                                                   20


<210> 29112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29112
gagacggggt ttcattgtgt                                                   20


<210> 29113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29113
ttgtattttt agtagagacg                                                   20


<210> 29114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29114
tttgtatttt tagtagagac                                                   20


<210> 29115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 29115
ttttgtattt ttagtagaga                                                   20


<210> 29116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29116
atttttttgt atttttagta                                                   20


<210> 29117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29117
ctattttttt gtatttttag                                                   20


<210> 29118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29118
cagctatttt tttgtatttt                                                   20


<210> 29119
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29119
caggtgcccg ccaccacgcc                                                   20


<210> 29120
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29120
tgccaagtag ctgggactac                                                   20


<210> 29121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29121
ctgccaagta gctgggacta                                                   20


<210> 29122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29122
cctcagcctg ccaagtagct                                                   20


<210> 29123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29123
gcctcagcct gccaagtagc                                                   20


<210> 29124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29124
tcctgcctca gcctgccaag                                                   20


<210> 29125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29125
ttctcctgcc tcagcctgcc                                                   20


<210> 29126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29126
ttcacaccat tctcctgcct                                                   20


<210> 29127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29127
cactgtaagc tccgcctccc                                                   20


<210> 29128
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 29128
tcactgtaag ctccgcctcc                                                   20


<210> 29129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29129
tcgctatctc ggctcactgt                                                   20


<210> 29130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 29130
ggaatgcagt gtcgctatct                                                   20


<210> 29131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29131
ctgtcgccta ggctggaatg                                                   20


<210> 29132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29132
tctcactctg tcgcctaggc                                                   20


<210> 29133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29133
ggagtctcac tctgtcgcct                                                   20


<210> 29134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29134
tggagtctca ctctgtcgcc                                                   20


<210> 29135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29135
tttttttttt ttttgagatg                                                   20


<210> 29136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29136
tttttttttt ttttttgaga                                                   20


<210> 29137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29137
tttttttttt tttttttttt                                                   20


<210> 29138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29138
gtagtgggat tactgagtca                                                   20


<210> 29139
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29139
tacctagtag tgggattact                                                   20


<210> 29140
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29140
ctcagtatat acctagtagt                                                   20


<210> 29141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29141
tctcagtata tacctagtag                                                   20


<210> 29142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29142
agttctcagt atatacctag                                                   20


<210> 29143
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29143
ttcagttctc agtatatacc                                                   20


<210> 29144
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29144
cattttcaat tttcagttct                                                   20


<210> 29145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29145
ggaaatacat tttcaatttt                                                   20


<210> 29146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29146
cattcatgta caagtttttg                                                   20


<210> 29147
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29147
tgctgtaaac attcatgtac                                                   20


<210> 29148
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29148
tttgggttat ttccgtcttt                                                   20


<210> 29149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29149
tcatcagttg atggacattt                                                   20


<210> 29150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29150
ttcatcagtt gatggacatt                                                   20


<210> 29151
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29151
tttatacatt catcagttga                                                   20


<210> 29152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29152
tattttgttt atacattcat                                                   20


<210> 29153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29153
ttcaaaattt atccatggta                                                   20


<210> 29154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29154
atgttttcaa aatttatcca                                                   20


<210> 29155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29155
tgtatctggc ttcttacacc                                                   20


<210> 29156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29156
aatatatggc tttttgtatc                                                   20


<210> 29157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29157
acatggaagc atataatata                                                   20


<210> 29158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29158
tgtagattta atatacatgg                                                   20


<210> 29159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29159
ctctgtagat ttaatataca                                                   20


<210> 29160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29160
ctagggattt acccactctg                                                   20


<210> 29161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29161
taatctactt tctgtcccta                                                   20


<210> 29162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29162
ctaatctact ttctgtccct                                                   20


<210> 29163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29163
actaatctac tttctgtccc                                                   20


<210> 29164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29164
ttcccttttc tcccagcccc                                                   20


<210> 29165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29165
tccccatttc ccttttctcc                                                   20


<210> 29166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29166
agaaacccag ggcccgttag                                                   20


<210> 29167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29167
ccaagaaacc cagggcccgt                                                   20


<210> 29168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29168
ctttcccacc aagaaaccca                                                   20


<210> 29169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29169
tctttcccac caagaaaccc                                                   20


<210> 29170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29170
atctttccca ccaagaaacc                                                   20


<210> 29171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29171
atattttcat ctttcccacc                                                   20


<210> 29172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29172
cattttttaa actatactca                                                   20


<210> 29173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29173
ctcatttttt aaactatact                                                   20


<210> 29174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29174
ttttaaaaat aggtttattg                                                   20


<210> 29175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29175
cttttaaaaa taggtttatt                                                   20


<210> 29176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29176
ctgcattccc ttttaaaaat                                                   20


<210> 29177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29177
gctgcattcc cttttaaaaa                                                   20


<210> 29178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29178
tacgtatttt agtgataagt                                                   20


<210> 29179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29179
cccatacgta ttttagtgat                                                   20


<210> 29180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29180
cattttcccc atacgtattt                                                   20


<210> 29181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29181
acttcaccca gaatcttcat                                                   20


<210> 29182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29182
attaatttaa aaacttcacc                                                   20


<210> 29183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29183
gttgtctttc tgagcaaggg                                                   20


<210> 29184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29184
taagttgtct ttctgagcaa                                                   20


<210> 29185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29185
ataagttgtc tttctgagca                                                   20


<210> 29186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29186
cataagttgt ctttctgagc                                                   20


<210> 29187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29187
ttgtcataag ttgtctttct                                                   20


<210> 29188
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29188
aagccataca caattgtcat                                                   20


<210> 29189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29189
ctcttcactt ccataggccc                                                   20


<210> 29190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29190
gatatactct tcacttccat                                                   20


<210> 29191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29191
ggatatactc ttcacttcca                                                   20


<210> 29192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29192
gcattatttg cccttcgttg                                                   20


<210> 29193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29193
tgcattattt gcccttcgtt                                                   20


<210> 29194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29194
ttgcattatt tgcccttcgt                                                   20


<210> 29195
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29195
cccctgcact agttttctca                                                   20


<210> 29196
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29196
atcccctgca ctagttttct                                                   20


<210> 29197
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29197
ccagtcctga tcccctgcac                                                   20


<210> 29198
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29198
tcatgtgcag gccctctgcc                                                   20


<210> 29199
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29199
gagtgtagag tatcatgtgc                                                   20


<210> 29200
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29200
agagtgtaga gtatcatgtg                                                   20


<210> 29201
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29201
actacatttg ccagagtgta                                                   20


<210> 29202
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29202
gaactacatt tgccagagtg                                                   20


<210> 29203
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29203
tgtgagaact acatttgcca                                                   20


<210> 29204
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29204
cttgtgagaa ctacatttgc                                                   20


<210> 29205
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29205
atctacagct gttttcttgt                                                   20


<210> 29206
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29206
tttcctatct ccttcatcta                                                   20


<210> 29207
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29207
tattggcctt cactactaac                                                   20


<210> 29208
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29208
atattggcct tcactactaa                                                   20


<210> 29209
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29209
ttttgaaaaa accgcaatat                                                   20


<210> 29210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29210
tatttgacat ttaatagaga                                                   20


<210> 29211
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29211
ctaatatttg acatttaata                                                   20


<210> 29212
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29212
ttctaatatt tgacatttaa                                                   20


<210> 29213
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29213
tggttatatt gggctaaaac                                                   20


<210> 29214
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29214
gtggttatat tgggctaaaa                                                   20


<210> 29215
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29215
aaatatactg tggttatatt                                                   20


<210> 29216
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29216
gaaatatact gtggttatat                                                   20


<210> 29217
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29217
tattatggag aaatatactg                                                   20


<210> 29218
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29218
gctaaatgtg cagtattatg                                                   20


<210> 29219
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29219
tagctaaatg tgcagtatta                                                   20


<210> 29220
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29220
acagtgtgta gctaaatgtg                                                   20


<210> 29221
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29221
gggttcatgt gcacagtgtg                                                   20


<210> 29222
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29222
gaaagtgggg ttcatgtgca                                                   20


<210> 29223
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29223
tgctgctaca gatgaaagtg                                                   20


<210> 29224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29224
atgctgctac agatgaaagt                                                   20


<210> 29225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29225
tatgctgcta cagatgaaag                                                   20


<210> 29226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29226
ttttatgctg ctacagatga                                                   20


<210> 29227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29227
aacacttttt tatgctgcta                                                   20


<210> 29228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29228
tacaatttgt agatttcctt                                                   20


<210> 29229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29229
gctgaaaaac atacaatttg                                                   20


<210> 29230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29230
attttctggt gcctatagca                                                   20


<210> 29231
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29231
aaagcatttt ctggtgccta                                                   20


<210> 29232
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29232
cataatctaa aagcattttc                                                   20


<210> 29233
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29233
agaacctgag cataatctaa                                                   20


<210> 29234
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29234
gcaatctaca cagagaacct                                                   20


<210> 29235
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29235
tggtaaaggc aatctacaca                                                   20


<210> 29236
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29236
aatggtaaag gcaatctaca                                                   20


<210> 29237
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29237
tcaaggaatt ataatggtaa                                                   20


<210> 29238
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29238
atcaaggaat tataatggta                                                   20


<210> 29239
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29239
aaaagatcaa ggaattataa                                                   20


<210> 29240
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29240
tggcaatatt taaaagatca                                                   20


<210> 29241
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29241
ttggcaatat ttaaaagatc                                                   20


<210> 29242
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29242
aatgaattgg caatatttaa                                                   20


<210> 29243
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29243
aagtgctaag gcaaatgaat                                                   20


<210> 29244
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29244
tagatcatga gaaagtgcta                                                   20


<210> 29245
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29245
atagatcatg agaaagtgct                                                   20


<210> 29246
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29246
ttggttgata gatcatgaga                                                   20


<210> 29247
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29247
gaacttggtt gatagatcat                                                   20


<210> 29248
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29248
agtgacaaga acttggttga                                                   20


<210> 29249
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29249
tacaaagagt gacaagaact                                                   20


<210> 29250
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29250
taagctgtac aaagagtgac                                                   20


<210> 29251
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29251
atggatttaa gctgtacaaa                                                   20


<210> 29252
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29252
ccatggattt aagctgtaca                                                   20


<210> 29253
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29253
taatgaatgc ccatggattt                                                   20


<210> 29254
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29254
ctgatgataa tgaatgccca                                                   20


<210> 29255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29255
gactgtggtt ctgccaggtt                                                   20


<210> 29256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29256
agactgtggt tctgccaggt                                                   20


<210> 29257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29257
gtgtagactg tggttctgcc                                                   20


<210> 29258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29258
tgtgtagact gtggttctgc                                                   20


<210> 29259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29259
gccagattat gtgtagactg                                                   20


<210> 29260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29260
gacagatgcc agattatgtg                                                   20


<210> 29261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29261
agcatggaaa agacagatgc                                                   20


<210> 29262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29262
ggtagccagc atggaaaaga                                                   20


<210> 29263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29263
atttggtagc cagcatggaa                                                   20


<210> 29264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29264
cagccatttg gtagccagca                                                   20


<210> 29265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29265
acattcagcc atttggtagc                                                   20


<210> 29266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29266
accaacattc agccatttgg                                                   20


<210> 29267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29267
tccaccaaca ttcagccatt                                                   20


<210> 29268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29268
agagtttctc caccaacatt                                                   20


<210> 29269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29269
aaccattcac ttggttgtga                                                   20


<210> 29270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29270
ataaccattc acttggttgt                                                   20


<210> 29271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29271
ttaaaatata accattcact                                                   20


<210> 29272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29272
tgagtgcaaa tttgatgttg                                                   20


<210> 29273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29273
tttgagtgca aatttgatgt                                                   20


<210> 29274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29274
tgagaaattt agtgtatttt                                                   20


<210> 29275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29275
atatcagggc atgagaaatt                                                   20


<210> 29276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29276
atatggtcat atcagggcat                                                   20


<210> 29277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29277
ttatatatat ggtcatatca                                                   20


<210> 29278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29278
attatatata tggtcatatc                                                   20


<210> 29279
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29279
cattatatat atggtcatat                                                   20


<210> 29280
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29280
atgagaatgc attatatata                                                   20


<210> 29281
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29281
aattctacag atgatttgat                                                   20


<210> 29282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29282
atgaggaaga gaaaattcta                                                   20


<210> 29283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29283
ctgagagtgc aaatgaggaa                                                   20


<210> 29284
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29284
gcctgagagt gcaaatgagg                                                   20


<210> 29285
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29285
attgcctgag agtgcaaatg                                                   20


<210> 29286
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29286
cattgcctga gagtgcaaat                                                   20


<210> 29287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29287
aagatgggat cattgcctga                                                   20


<210> 29288
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29288
ataagatggg atcattgcct                                                   20


<210> 29289
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29289
atttcctcaa agtataagat                                                   20


<210> 29290
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29290
tatttcctca aagtataaga                                                   20


<210> 29291
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29291
tttttatttc ctcaaagtat                                                   20


<210> 29292
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29292
caatggtttt tatttcctca                                                   20


<210> 29293
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29293
atgattgagt tcaaacccaa                                                   20


<210> 29294
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29294
agagttatca aaagatgatt                                                   20


<210> 29295
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29295
gaagactgca gagttatcaa                                                   20


<210> 29296
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29296
agatagaaga gaagactgca                                                   20


<210> 29297
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29297
aaagatagaa gagaagactg                                                   20


<210> 29298
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29298
caggaggaaa gatagaagag                                                   20


<210> 29299
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29299
aaacaggagg aaagatagaa                                                   20


<210> 29300
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29300
cgaaacagga ggaaagatag                                                   20


<210> 29301
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29301
caccgaaaca ggaggaaaga                                                   20


<210> 29302
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29302
gctccaccga aacaggagga                                                   20


<210> 29303
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29303
gacagctcca ccgaaacagg                                                   20


<210> 29304
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29304
cgacagctcc accgaaacag                                                   20


<210> 29305
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29305
agcgacagct ccaccgaaac                                                   20


<210> 29306
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29306
gagcgacagc tccaccgaaa                                                   20


<210> 29307
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29307
gaaagagtaa aggggagcga                                                   20


<210> 29308
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29308
gaaagtgaaa gagtaaaggg                                                   20


<210> 29309
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29309
gtgaaagtga aagagtaaag                                                   20


<210> 29310
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29310
cgtgaaagtg aaagagtaaa                                                   20


<210> 29311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29311
tcgtgaaagt gaaagagtaa                                                   20


<210> 29312
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29312
ctcgtgaaag tgaaagagta                                                   20


<210> 29313
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29313
aagtcctcgt gaaagtgaaa                                                   20


<210> 29314
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29314
tcaagtcctc gtgaaagtga                                                   20


<210> 29315
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29315
gagaagtcaa gtcctcgtga                                                   20


<210> 29316
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29316
aggagagaga gggagaagtc                                                   20


<210> 29317
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29317
aattcaggag agagagggag                                                   20


<210> 29318
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29318
atcaattcag gagagagagg                                                   20


<210> 29319
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29319
gaatcaattc aggagagaga                                                   20


<210> 29320
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29320
tgaatcaatt caggagagag                                                   20


<210> 29321
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29321
atgaatcaat tcaggagaga                                                   20


<210> 29322
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29322
atatgaatca attcaggaga                                                   20


<210> 29323
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29323
atatatgaat caattcagga                                                   20


<210> 29324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29324
ttatatatga atcaattcag                                                   20


<210> 29325
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29325
agttatatat gaatcaattc                                                   20


<210> 29326
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29326
tagttatata tgaatcaatt                                                   20


<210> 29327
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29327
tgctagtgat aatgaatgag                                                   20


<210> 29328
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29328
ttttgctagt gataatgaat                                                   20


<210> 29329
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29329
tttttgtatg gatgttttgc                                                   20


<210> 29330
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29330
aaaatatatg ggtttttgta                                                   20


<210> 29331
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29331
tggcatttaa aaaaatatat                                                   20


<210> 29332
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29332
ctggcattta aaaaaatata                                                   20


<210> 29333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29333
agaataatgg ggcaaatggc                                                   20


<210> 29334
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29334
aagcagaata atggggcaaa                                                   20


<210> 29335
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29335
taaagggaag cagaataatg                                                   20


<210> 29336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29336
ataaagggaa gcagaataat                                                   20


<210> 29337
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29337
tataaaggga agcagaataa                                                   20


<210> 29338
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29338
aatttggcta taaagggaag                                                   20


<210> 29339
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29339
agaaatttgg ctataaaggg                                                   20


<210> 29340
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29340
ccaagaaatt tggctataaa                                                   20


<210> 29341
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29341
cccaagaaat ttggctataa                                                   20


<210> 29342
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29342
tcccaagaaa tttggctata                                                   20


<210> 29343
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29343
gacaattctc ccaagaaatt                                                   20


<210> 29344
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29344
tatgtgtaga caattctccc                                                   20


<210> 29345
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29345
cagaaagaag gtaatatgtg                                                   20


<210> 29346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29346
aaaagaagag gtcagaaaga                                                   20


<210> 29347
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29347
gaaaagaaga ggtcagaaag                                                   20


<210> 29348
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29348
ggtgaaaaga agaggtcaga                                                   20


<210> 29349
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29349
caggggtgaa aagaagaggt                                                   20


<210> 29350
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29350
catacagggg tgaaaagaag                                                   20


<210> 29351
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29351
gcatacaggg gtgaaaagaa                                                   20


<210> 29352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29352
gtgcatacag gggtgaaaag                                                   20


<210> 29353
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29353
aaggtgcata caggggtgaa                                                   20


<210> 29354
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29354
taagaataag gtgcatacag                                                   20


<210> 29355
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29355
gtaagaataa ggtgcataca                                                   20


<210> 29356
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29356
ggtaagaata aggtgcatac                                                   20


<210> 29357
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29357
aggtaagaat aaggtgcata                                                   20


<210> 29358
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29358
tagggttcaa ggtaagaata                                                   20


<210> 29359
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29359
gtagggttca aggtaagaat                                                   20


<210> 29360
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29360
taagtggtag ggttcaaggt                                                   20


<210> 29361
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29361
tgggtaagtg gtagggttca                                                   20


<210> 29362
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29362
ttgggtaagt ggtagggttc                                                   20


<210> 29363
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29363
gaaaatttgg gtaagtggta                                                   20


<210> 29364
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29364
agaaaatttg ggtaagtggt                                                   20


<210> 29365
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29365
gagaaaattt gggtaagtgg                                                   20


<210> 29366
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29366
cttgagaaaa tttgggtaag                                                   20


<210> 29367
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29367
tttcttgaga aaatttgggt                                                   20


<210> 29368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29368
agaatttctt gagaaaattt                                                   20


<210> 29369
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29369
gagaatttct tgagaaaatt                                                   20


<210> 29370
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29370
aagtcatcag agaatttctt                                                   20


<210> 29371
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29371
aagtaacagg gaagtcatca                                                   20


<210> 29372
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29372
ttaagtaaca gggaagtcat                                                   20


<210> 29373
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29373
cattaggtta agtaacaggg                                                   20


<210> 29374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29374
atgcattagg ttaagtaaca                                                   20


<210> 29375
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29375
tatgcattag gttaagtaac                                                   20


<210> 29376
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29376
atatgcatta ggttaagtaa                                                   20


<210> 29377
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29377
aaagaaatat gcattaggtt                                                   20


<210> 29378
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29378
tgaagaaaga aatatgcatt                                                   20


<210> 29379
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29379
atgaagaaag aaatatgcat                                                   20


<210> 29380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29380
aggagtaagg atgatgaaga                                                   20


<210> 29381
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29381
atcaaggagt aaggatgatg                                                   20


<210> 29382
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29382
tgctgcaaga tcaaggagta                                                   20


<210> 29383
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29383
atgctgcaag atcaaggagt                                                   20


<210> 29384
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29384
aatcatgctg caagatcaag                                                   20


<210> 29385
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29385
agaatcatgc tgcaagatca                                                   20


<210> 29386
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29386
tagaatcatg ctgcaagatc                                                   20


<210> 29387
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29387
cttgtgtaga atcatgctgc                                                   20


<210> 29388
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29388
tagaaacaga tgtgcttgtg                                                   20


<210> 29389
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29389
aagaaaacat attgtagaaa                                                   20


<210> 29390
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29390
caagagaaga aaacatattg                                                   20


<210> 29391
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29391
ataaataatg aagccaagag                                                   20


<210> 29392
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29392
gatataaata atgaagccaa                                                   20


<210> 29393
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29393
aagatataaa taatgaagcc                                                   20


<210> 29394
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29394
aagcaaagat ataaataatg                                                   20


<210> 29395
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29395
cgccaataaa gtaagaagca                                                   20


<210> 29396
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29396
agagccgcca ataaagtaag                                                   20


<210> 29397
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29397
gaaagagccg ccaataaagt                                                   20


<210> 29398
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29398
cagagaaaga gccgccaata                                                   20


<210> 29399
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29399
cagaaaagaa cacagagaaa                                                   20


<210> 29400
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29400
cccagaaaag aacacagaga                                                   20


<210> 29401
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29401
aggacccaga aaagaacaca                                                   20


<210> 29402
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29402
agaggaccca gaaaagaaca                                                   20


<210> 29403
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29403
gtagaaaaga ggacccagaa                                                   20


<210> 29404
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29404
ttcaggtaga aaagaggacc                                                   20


<210> 29405
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29405
ttagaattca ggtagaaaag                                                   20


<210> 29406
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29406
tttagaattc aggtagaaaa                                                   20


<210> 29407
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29407
catttagaat tcaggtagaa                                                   20


<210> 29408
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29408
tctgacattt agaattcagg                                                   20


<210> 29409
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29409
aactctgaca tttagaattc                                                   20


<210> 29410
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29410
caactctgac atttagaatt                                                   20


<210> 29411
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29411
agatctacaa ctctgacatt                                                   20


<210> 29412
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29412
atttaaagca atctggtacc                                                   20


<210> 29413
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29413
acctggtatt taaagcaatc                                                   20


<210> 29414
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29414
aatgggaaac ctggtattta                                                   20


<210> 29415
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29415
tagatagaga atgggaaacc                                                   20


<210> 29416
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29416
tttttaagta gatagagaat                                                   20


<210> 29417
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29417
atttttaagt agatagagaa                                                   20


<210> 29418
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29418
ctgatatttt taagtagata                                                   20


<210> 29419
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29419
ccctgatatt tttaagtaga                                                   20


<210> 29420
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29420
acatccctga tatttttaag                                                   20


<210> 29421
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29421
tgaacatccc tgatattttt                                                   20


<210> 29422
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29422
agagcaatca gcaaaaagaa                                                   20


<210> 29423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29423
cagagcaatc agcaaaaaga                                                   20


<210> 29424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29424
attccagagc aatcagcaaa                                                   20


<210> 29425
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29425
gagataaatt ccagagcaat                                                   20


<210> 29426
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29426
gagtttggag ataaattcca                                                   20


<210> 29427
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29427
ctgagtttgg agataaattc                                                   20


<210> 29428
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29428
cagagggcct gctgagtttg                                                   20


<210> 29429
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29429
atcagagggc ctgctgagtt                                                   20


<210> 29430
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29430
tagaaatcag agggcctgct                                                   20


<210> 29431
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29431
atttaagtat agaaatcaga                                                   20


<210> 29432
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29432
gatttaagta tagaaatcag                                                   20


<210> 29433
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29433
agatttaagt atagaaatca                                                   20


<210> 29434
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29434
ggagatttaa gtatagaaat                                                   20


<210> 29435
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29435
gagaattgga gatttaagta                                                   20


<210> 29436
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29436
atatagagaa ttggagattt                                                   20


<210> 29437
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29437
atatataata tagagaattg                                                   20


<210> 29438
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29438
ggatatataa tatagagaat                                                   20


<210> 29439
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29439
ccaggtggat atataatata                                                   20


<210> 29440
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29440
gtccaggtgg atatataata                                                   20


<210> 29441
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29441
atgcctttga gatgtccagg                                                   20


<210> 29442
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29442
gagatgcctt tgagatgtcc                                                   20


<210> 29443
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29443
tgagatgcct ttgagatgtc                                                   20


<210> 29444
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29444
aattaaaatg agatgccttt                                                   20


<210> 29445
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29445
tagctagcta aaattaaaat                                                   20


<210> 29446
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29446
agaggaaggt cactattagc                                                   20


<210> 29447
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29447
ttgtagagga aggtcactat                                                   20


<210> 29448
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29448
gtggacacat ttgtagagga                                                   20


<210> 29449
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29449
ggtggacaca tttgtagagg                                                   20


<210> 29450
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29450
aatggtggac acatttgtag                                                   20


<210> 29451
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29451
aaatggtgga cacatttgta                                                   20


<210> 29452
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29452
ggaaatggtg gacacatttg                                                   20


<210> 29453
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29453
gatggttaat gaggaaatgg                                                   20


<210> 29454
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29454
ggtgatggtt aatgaggaaa                                                   20


<210> 29455
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29455
atgggtggtg atggttaatg                                                   20


<210> 29456
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29456
gatgggtggt gatggttaat                                                   20


<210> 29457
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29457
aataactgga tgggtggtga                                                   20


<210> 29458
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29458
ggctgcaata actggatggg                                                   20


<210> 29459
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29459
tctggctgca ataactggat                                                   20


<210> 29460
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29460
ttctggctgc aataactgga                                                   20


<210> 29461
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29461
cagtttctgg ctgcaataac                                                   20


<210> 29462
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29462
gaggatgact tctcagtttc                                                   20


<210> 29463
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29463
aagcattgag gatgacttct                                                   20


<210> 29464
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29464
aaagaagaca ggaagcattg                                                   20


<210> 29465
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29465
taaagaagac aggaagcatt                                                   20


<210> 29466
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29466
gatggattaa agaagacagg                                                   20


<210> 29467
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29467
gctgatggat taaagaagac                                                   20


<210> 29468
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29468
tgctgatgga ttaaagaaga                                                   20


<210> 29469
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29469
agcttgctga tggattaaag                                                   20


<210> 29470
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29470
tagagcttgc tgatggatta                                                   20


<210> 29471
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29471
aagtctgtag agcttgctga                                                   20


<210> 29472
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29472
ctcaacatac aaagtctgta                                                   20


<210> 29473
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29473
agctcaacat acaaagtctg                                                   20


<210> 29474
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29474
aaagatgagc tcaacataca                                                   20


<210> 29475
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29475
gaaatgaaga gaaaaaagat                                                   20


<210> 29476
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29476
gcagagaaat gaagagaaaa                                                   20


<210> 29477
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29477
agtgatggca gagaaatgaa                                                   20


<210> 29478
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29478
agagtgatgg cagagaaatg                                                   20


<210> 29479
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29479
tttcatctag agtgatggca                                                   20


<210> 29480
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29480
ggtttcatct agagtgatgg                                                   20


<210> 29481
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29481
aaaggtttca tctagagtga                                                   20


<210> 29482
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29482
gaaaataaag gtttcatcta                                                   20


<210> 29483
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29483
gagaaaataa aggtttcatc                                                   20


<210> 29484
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29484
atctaggcaa gagaaaataa                                                   20


<210> 29485
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29485
catctaggca agagaaaata                                                   20


<210> 29486
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29486
tgcttctctc atctaggcaa                                                   20


<210> 29487
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29487
gttgcttctc tcatctaggc                                                   20


<210> 29488
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29488
gaaggttgct tctctcatct                                                   20


<210> 29489
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29489
tgaaggttgc ttctctcatc                                                   20


<210> 29490
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29490
gaataagaaa ggtaagttga                                                   20


<210> 29491
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29491
ggaataagaa aggtaagttg                                                   20


<210> 29492
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29492
tagatgggaa taagaaaggt                                                   20


<210> 29493
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29493
atggtagatg ggaataagaa                                                   20


<210> 29494
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29494
gatggtagat gggaataaga                                                   20


<210> 29495
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29495
ggtagatggt agatgggaat                                                   20


<210> 29496
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29496
agcaagggta gatggtagat                                                   20


<210> 29497
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29497
gagcaagggt agatggtaga                                                   20


<210> 29498
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29498
gattgagcaa gggtagatgg                                                   20


<210> 29499
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29499
actgattgag caagggtaga                                                   20


<210> 29500
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29500
cacaactgat tgagcaaggg                                                   20


<210> 29501
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29501
gtgcacaact gattgagcaa                                                   20


<210> 29502
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29502
tgtgcacaac tgattgagca                                                   20


<210> 29503
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29503
ttgtgcacaa ctgattgagc                                                   20


<210> 29504
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29504
tgtcttgtgc acaactgatt                                                   20


<210> 29505
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29505
tttgtatttt attttaaatg                                                   20


<210> 29506
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29506
acatttcagc ccatgggaag                                                   20


<210> 29507
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29507
ggacatttca gcccatggga                                                   20


<210> 29508
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29508
aggacatttc agcccatggg                                                   20


<210> 29509
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29509
tgcaggacat ttcagcccat                                                   20


<210> 29510
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29510
atgcaggaca tttcagccca                                                   20


<210> 29511
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29511
tcatatcatg caggacattt                                                   20


<210> 29512
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29512
aaataggggt catatcatgc                                                   20


<210> 29513
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29513
aaaatagggg tcatatcatg                                                   20


<210> 29514
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29514
gaaagtagca gaaaaaatag                                                   20


<210> 29515
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29515
agaaagtagc agaaaaaata                                                   20


<210> 29516
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29516
gagaaagtag cagaaaaaat                                                   20


<210> 29517
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29517
agagaaagta gcagaaaaaa                                                   20


<210> 29518
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29518
aatggcaaca gagaaagtag                                                   20


<210> 29519
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29519
aagaatggca acagagaaag                                                   20


<210> 29520
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29520
aggaagaatg gcaacagaga                                                   20


<210> 29521
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29521
agaaaggaag aatggcaaca                                                   20


<210> 29522
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29522
agagaaagga agaatggcaa                                                   20


<210> 29523
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29523
ttggtaagag aaaggaagaa                                                   20


<210> 29524
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29524
gtggtttggt aagagaaagg                                                   20


<210> 29525
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29525
agcgtggttt ggtaagagaa                                                   20


<210> 29526
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29526
cagcgtggtt tggtaagaga                                                   20


<210> 29527
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29527
acagcagcgt ggtttggtaa                                                   20


<210> 29528
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29528
aaacagcagc gtggtttggt                                                   20


<210> 29529
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29529
ggaaaaacag cagcgtggtt                                                   20


<210> 29530
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29530
agaatggaaa aacagcagcg                                                   20


<210> 29531
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29531
tttaaagaat ggaaaaacag                                                   20


<210> 29532
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29532
gggtttaaag aatggaaaaa                                                   20


<210> 29533
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29533
gagggtatgg gtttaaagaa                                                   20


<210> 29534
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29534
aaagggaggg tatgggttta                                                   20


<210> 29535
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29535
cctgaataaa gggagggtat                                                   20


<210> 29536
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29536
tcctgaataa agggagggta                                                   20


<210> 29537
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29537
aaaggtcctg aataaaggga                                                   20


<210> 29538
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29538
caaaggtcct gaataaaggg                                                   20


<210> 29539
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29539
gcaaaggtcc tgaataaagg                                                   20


<210> 29540
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29540
gggcaaaggt cctgaataaa                                                   20


<210> 29541
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29541
tgggcaaagg tcctgaataa                                                   20


<210> 29542
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29542
atgggcaaag gtcctgaata                                                   20


<210> 29543
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29543
aggagaaata gcatgggcaa                                                   20


<210> 29544
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29544
taggagaaat agcatgggca                                                   20


<210> 29545
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29545
tcaattagga gaaatagcat                                                   20


<210> 29546
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29546
ttcaattagg agaaatagca                                                   20


<210> 29547
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29547
gctgcttcaa ttaggagaaa                                                   20


<210> 29548
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29548
gggggtgctg cttcaattag                                                   20


<210> 29549
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29549
tggggggtgc tgcttcaatt                                                   20


<210> 29550
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29550
gtggggggtg ctgcttcaat                                                   20


<210> 29551
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29551
ggtgtgagtc tatgtgtggg                                                   20


<210> 29552
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29552
gggtgtgagt ctatgtgtgg                                                   20


<210> 29553
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29553
tgggtgtgag tctatgtgtg                                                   20


<210> 29554
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29554
gtgggtgtga gtctatgtgt                                                   20


<210> 29555
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29555
tgtgggtgtg agtctatgtg                                                   20


<210> 29556
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29556
aatagtttaa gtgtgggtgt                                                   20


<210> 29557
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29557
ccataaaata gtttaagtgt                                                   20


<210> 29558
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29558
gccataaaat agtttaagtg                                                   20


<210> 29559
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29559
aagaagccat aaaatagttt                                                   20


<210> 29560
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29560
gatagtaaga agccataaaa                                                   20


<210> 29561
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29561
gagatctaaa agatagtaag                                                   20


<210> 29562
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29562
gctgagatct aaaagatagt                                                   20


<210> 29563
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29563
ttaagctgag atctaaaaga                                                   20


<210> 29564
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29564
gcatttaagc tgagatctaa                                                   20


<210> 29565
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29565
gaggtgatgg catttaagct                                                   20


<210> 29566
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29566
tctctgaggt gatggcattt                                                   20


<210> 29567
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29567
agaagacatc tctgaggtga                                                   20


<210> 29568
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29568
tagatgagaa gacatctctg                                                   20


<210> 29569
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29569
ctagatgaga agacatctct                                                   20


<210> 29570
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29570
tgagatatca actagatgag                                                   20


<210> 29571
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29571
tgctgagata tcaactagat                                                   20


<210> 29572
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29572
tcaggtgctg agatatcaac                                                   20


<210> 29573
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29573
ggaagtgagt ctcaggtgct                                                   20


<210> 29574
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29574
atgcaaagga agtgagtctc                                                   20


<210> 29575
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29575
catgcaaagg aagtgagtct                                                   20


<210> 29576
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29576
aaatgccatg caaaggaagt                                                   20


<210> 29577
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29577
taataaatgc catgcaaagg                                                   20


<210> 29578
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29578
ttataataaa tgccatgcaa                                                   20


<210> 29579
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29579
gttataataa atgccatgca                                                   20


<210> 29580
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29580
aaataaatta aaaatatctc                                                   20


<210> 29581
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29581
aaaaaatgtt taagggggaa                                                   20


<210> 29582
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29582
atgaaaaaaa atgtttaagg                                                   20


<210> 29583
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29583
aatgaaaaaa aatgtttaag                                                   20


<210> 29584
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29584
gaatgaaaaa aaatgtttaa                                                   20


<210> 29585
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29585
ggaatgaaaa aaaatgttta                                                   20


<210> 29586
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29586
gggaatgaaa aaaaatgttt                                                   20


<210> 29587
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29587
cacagagctt atcatctagt                                                   20


<210> 29588
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29588
tcacagagct tatcatctag                                                   20


<210> 29589
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29589
ctttcacaga gcttatcatc                                                   20


<210> 29590
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29590
cctcagccct tgctttcaca                                                   20


<210> 29591
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29591
agcctcagcc cttgctttca                                                   20


<210> 29592
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29592
atagcaataa atgatagcct                                                   20


<210> 29593
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29593
tgagctatag caataaatga                                                   20


<210> 29594
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29594
tacatggttt ccctgagcta                                                   20


<210> 29595
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29595
gtttattaca tggtttccct                                                   20


<210> 29596
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29596
ttattggtgc gtttattaca                                                   20


<210> 29597
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29597
tgattcaaac tttcatttat                                                   20


<210> 29598
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29598
ttctgtttcc tatgtcatag                                                   20


<210> 29599
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29599
tgcttctgtt tcctatgtca                                                   20


<210> 29600
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29600
agtgaagagg tgtttaaatc                                                   20


<210> 29601
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29601
gaaatgtagt tttagtgaag                                                   20


<210> 29602
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29602
tgaaatgtag ttttagtgaa                                                   20


<210> 29603
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29603
tctgaaatgt agttttagtg                                                   20


<210> 29604
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29604
tttcttctga aatgtagttt                                                   20


<210> 29605
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29605
ctttattttc ttctgaaatg                                                   20


<210> 29606
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29606
aaacatgaat gcatgacaat                                                   20


<210> 29607
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29607
ataataataa tagagccctt                                                   20


<210> 29608
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29608
ataaattaat aataataata                                                   20


<210> 29609
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29609
taataaatta ataataataa                                                   20


<210> 29610
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29610
cactccagcc tgggcaacaa                                                   20


<210> 29611
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29611
tgcactccag cctgggcaac                                                   20


<210> 29612
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29612
gtgccattgc actccagcct                                                   20


<210> 29613
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29613
cgtgccattg cactccagcc                                                   20


<210> 29614
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29614
gagatcgtgc cattgcactc                                                   20


<210> 29615
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29615
ggcagaggtt gcggtgagcc                                                   20


<210> 29616
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29616
cgggaggcag aggttgcggt                                                   20


<210> 29617
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 29617
aactcgggag gcagaggttg                                                   20


<210> 29618
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29618
cgcttgaact cgggaggcag                                                   20


<210> 29619
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29619
tcgcttgaac tcgggaggca                                                   20


<210> 29620
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29620
aatcgcttga actcgggagg                                                   20


<210> 29621
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29621
gagaatcgct tgaactcggg                                                   20


<210> 29622
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29622
ggagaatcgc ttgaactcgg                                                   20


<210> 29623
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29623
caggagaatc gcttgaactc                                                   20


<210> 29624
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 29624
gcaggagaat cgcttgaact                                                   20


<210> 29625
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29625
tactcaggag gctgaggcag                                                   20


<210> 29626
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29626
gctactcagg aggctgaggc                                                   20


<210> 29627
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29627
agctactcag gaggctgagg                                                   20


<210> 29628
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29628
tccagctact caggaggctg                                                   20


<210> 29629
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29629
ttccagctac tcaggaggct                                                   20


<210> 29630
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29630
tgtaattcca gctactcagg                                                   20


<210> 29631
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29631
ctgtaattcc agctactcag                                                   20


<210> 29632
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29632
gcctgtaatt ccagctactc                                                   20


<210> 29633
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29633
cgcctgtaat tccagctact                                                   20


<210> 29634
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29634
gtggtgggcg cctgtaattc                                                   20


<210> 29635
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29635
aattagccgg gcatggtggt                                                   20


<210> 29636
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29636
aaattagccg ggcatggtgg                                                   20


<210> 29637
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29637
aaaaaattag ccgggcatgg                                                   20


<210> 29638
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29638
tacaaaaaat tagccgggca                                                   20


<210> 29639
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29639
aaaaatacaa aaaattagcc                                                   20


<210> 29640
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 29640
taaaaataca aaaaattagc                                                   20


<210> 29641
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29641
ctactaaaaa tacaaaaaat                                                   20


<210> 29642
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29642
acaaaaaaag aagaaaaaaa                                                   20


<210> 29643
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29643
aaaaaataat acaaaaaaag                                                   20


<210> 29644
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29644
gctaaaaaat aatacaaaaa                                                   20


<210> 29645
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29645
taatttaatt catcgctttc                                                   20


<210> 29646
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29646
caattctcta tgtacacaga                                                   20


<210> 29647
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29647
attgcaattc tctatgtaca                                                   20


<210> 29648
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29648
aatttgttta catatgaagt                                                   20


<210> 29649
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29649
atgcaatttg tttacatatg                                                   20


<210> 29650
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29650
acaagaatat actaatagat                                                   20


<210> 29651
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29651
ttgttacaag aatatactaa                                                   20


<210> 29652
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29652
ctgagacagc tacttgttac                                                   20


<210> 29653
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29653
gctgctgtga ttggctgaga                                                   20


<210> 29654
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29654
ctcagctgct gtgattggct                                                   20


<210> 29655
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29655
tgaagctcag ctgctgtgat                                                   20


<210> 29656
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29656
ggctgtggtt ggctgaagct                                                   20


<210> 29657
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29657
cagcaggctg tggttggctg                                                   20


<210> 29658
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29658
ataaatcagc aggctgtggt                                                   20


<210> 29659
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29659
tctgataaat cagcaggctg                                                   20


<210> 29660
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29660
acattgtctg ataaatcagc                                                   20


<210> 29661
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29661
gacattgtct gataaatcag                                                   20


<210> 29662
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29662
gtggacattg tctgataaat                                                   20


<210> 29663
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29663
agcttgacat ttgccttatg                                                   20


<210> 29664
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29664
aaaaacagct tgattgctta                                                   20


<210> 29665
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29665
aagggagtga cgcacaaaaa                                                   20


<210> 29666
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29666
tatttataga cagaaaaagg                                                   20


<210> 29667
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29667
agtatttata gacagaaaaa                                                   20


<210> 29668
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29668
gagtatttat agacagaaaa                                                   20


<210> 29669
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29669
ggagtattta tagacagaaa                                                   20


<210> 29670
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29670
tgagcaggag tatttataga                                                   20


<210> 29671
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29671
aacatgagca ggagtattta                                                   20


<210> 29672
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29672
caactcagca acatgagcag                                                   20


<210> 29673
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29673
ctcaactcag caacatgagc                                                   20


<210> 29674
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29674
gctcaactca gcaacatgag                                                   20


<210> 29675
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29675
agagctcaac tcagcaacat                                                   20


<210> 29676
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29676
gaagttcgga gagctcaact                                                   20


<210> 29677
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29677
agaaccaaga gaagttcgga                                                   20


<210> 29678
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29678
tcagaaccaa gagaagttcg                                                   20


<210> 29679
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 29679
actcagaacc aagagaagtt                                                   20


<210> 29680
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29680
gcagcactca gaaccaagag                                                   20


<210> 29681
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29681
taggcagcac tcagaaccaa                                                   20


<210> 29682
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29682
tttaggcagc actcagaacc                                                   20


<210> 29683
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29683
ataatgattt aggcagcact                                                   20


<210> 29684
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29684
aataataata atgatttagg                                                   20


<210> 29685
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29685
gataataata ataatgattt                                                   20


<210> 29686
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29686
agataataat aataatgatt                                                   20


<210> 29687
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29687
atagtattta ttgctgaaat                                                   20


<210> 29688
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29688
agcttatttc agcaatgaaa                                                   20


<210> 29689
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29689
ttaaatttag cagcttattt                                                   20


<210> 29690
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29690
tttcaacaaa ttaaatttag                                                   20


<210> 29691
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29691
aattttcaac aaattaaatt                                                   20


<210> 29692
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29692
gttttcttaa cctttgttaa                                                   20


<210> 29693
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29693
ttctgagttt atactgtgaa                                                   20


<210> 29694
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29694
tgagtcttgc tcctatttct                                                   20


<210> 29695
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29695
gggatctgtc cttttattct                                                   20


<210> 29696
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29696
taaacttaag ttttctcact                                                   20


<210> 29697
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29697
ttaaacttaa gttttctcac                                                   20


<210> 29698
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29698
taccacactt atttaaactt                                                   20


<210> 29699
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29699
gtaacttaca tttaatattg                                                   20


<210> 29700
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29700
gtaaaattaa tatatctgat                                                   20


<210> 29701
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29701
aaacttattt ccaatggatg                                                   20


<210> 29702
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29702
tgaaacttat ttccaatgga                                                   20


<210> 29703
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29703
gatttgaaac ttatttccaa                                                   20


<210> 29704
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29704
tttatattta ccctcttttc                                                   20


<210> 29705
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29705
ccaccatttg atgaggaatt                                                   20


<210> 29706
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29706
tttactacca ccatttgatg                                                   20


<210> 29707
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29707
ttttactacc accatttgat                                                   20


<210> 29708
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29708
aagttttgaa gtaaaatgtt                                                   20


<210> 29709
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29709
caagaaaact gaaagttttg                                                   20


<210> 29710
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29710
agccttaaca agaaaactga                                                   20


<210> 29711
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29711
aaaaaaatag aagccttaac                                                   20


<210> 29712
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29712
aaaatgacag aaaaaaatag                                                   20


<210> 29713
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29713
aataaaatga cagaaaaaaa                                                   20


<210> 29714
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29714
aaagactata aataaaatga                                                   20


<210> 29715
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29715
acacctagcc cacatggtaa                                                   20


<210> 29716
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29716
caaataacac ctagcccaca                                                   20


<210> 29717
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29717
aaataaaatc aaataacacc                                                   20


<210> 29718
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29718
gattctcctt agataataaa                                                   20


<210> 29719
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29719
ggaaaggtca ggattctcct                                                   20


<210> 29720
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29720
gaaatgaggg aggaaaggtc                                                   20


<210> 29721
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29721
ggaaatgagg gaggaaaggt                                                   20


<210> 29722
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29722
aaaaggaaat gagggaggaa                                                   20


<210> 29723
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29723
caaaaggaaa tgagggagga                                                   20


<210> 29724
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29724
ttgccaaaag gaaatgaggg                                                   20


<210> 29725
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29725
gttgccaaaa ggaaatgagg                                                   20


<210> 29726
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29726
ctgttgccaa aaggaaatga                                                   20


<210> 29727
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29727
gctgttgcca aaaggaaatg                                                   20


<210> 29728
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29728
tgctgttgcc aaaaggaaat                                                   20


<210> 29729
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29729
atatatgtgc tgttgccaaa                                                   20


<210> 29730
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29730
aatatatgtg ctgttgccaa                                                   20


<210> 29731
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29731
ttgacccagg tgtggtatgg                                                   20


<210> 29732
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29732
aatttgaccc aggtgtggta                                                   20


<210> 29733
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29733
tagataattt gacccaggtg                                                   20


<210> 29734
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29734
cttaatagat aatttgaccc                                                   20


<210> 29735
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29735
tcttaataga taatttgacc                                                   20


<210> 29736
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29736
cgtgaataca taaatcttaa                                                   20


<210> 29737
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29737
cctggaatgt atctatctga                                                   20


<210> 29738
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29738
tgtactttct gtctgacacc                                                   20


<210> 29739
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29739
tattggatga agatatgatc                                                   20


<210> 29740
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29740
cggttgatga atattggatg                                                   20


<210> 29741
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29741
ctggaacggt tgatgaatat                                                   20


<210> 29742
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CGG

<400> 29742
catggtgtct ctcactggaa                                                   20


<210> 29743
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29743
cctagcatgg tgtctctcac                                                   20


<210> 29744
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29744
taaacaatta tcccctagca                                                   20


<210> 29745
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29745
ttctctaaac aattatcccc                                                   20


<210> 29746
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29746
caattagagt ttcttacata                                                   20


<210> 29747
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29747
taattcagaa gtatcaatta                                                   20


<210> 29748
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29748
cttaattcag aagtatcaat                                                   20


<210> 29749
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29749
cagaagtctg cttaattcag                                                   20


<210> 29750
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29750
tctcagaagt ctgcttaatt                                                   20


<210> 29751
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29751
tcatctgtat gcactctcag                                                   20


<210> 29752
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29752
agatcatctg tatgcactct                                                   20


<210> 29753
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29753
tatttctgta ggtaccacat                                                   20


<210> 29754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29754
ttcagtagaa ttatttctgt                                                   20


<210> 29755
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29755
gttcagtaga attatttctg                                                   20


<210> 29756
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29756
gatatcaaag tttagttcag                                                   20


<210> 29757
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29757
caagatatca aagtttagtt                                                   20


<210> 29758
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29758
gatggcaaga tatcaaagtt                                                   20


<210> 29759
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29759
aggctgatgg caagatatca                                                   20


<210> 29760
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29760
cttcaatata ggctgatggc                                                   20


<210> 29761
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29761
cttccttcaa tataggctga                                                   20


<210> 29762
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29762
ttaatggctt ccttcaatat                                                   20


<210> 29763
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29763
tttaatggct tccttcaata                                                   20


<210> 29764
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29764
agtttcatag ctgtttttaa                                                   20


<210> 29765
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29765
gtaaccaatg acgagtttca                                                   20


<210> 29766
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29766
tccactttgt aaccaatgac                                                   20


<210> 29767
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29767
acaaagcaaa atcatttgct                                                   20


<210> 29768
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29768
tattcctaaa gatttgtaca                                                   20


<210> 29769
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29769
gtatcttgat agtattccta                                                   20


<210> 29770
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29770
agatagtatc tgtatcttga                                                   20


<210> 29771
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29771
ttaattatca aatataaaga                                                   20


<210> 29772
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29772
aatattaatt atcaaatata                                                   20


<210> 29773
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29773
ctcataacta taacatctta                                                   20


<210> 29774
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29774
tgatagattt ttatacttaa                                                   20


<210> 29775
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29775
atgtgacata tttattatga                                                   20


<210> 29776
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29776
ttttatataa ttttattata                                                   20


<210> 29777
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29777
cattacattt aacaatataa                                                   20


<210> 29778
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29778
tttctctaga gaaataaatg                                                   20


<210> 29779
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29779
aaaaagaatt attttctcta                                                   20


<210> 29780
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29780
taaaaaagaa ttattttctc                                                   20


<210> 29781
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29781
ctaatttcta tatcataaaa                                                   20


<210> 29782
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29782
ctggcaaaag gaacacagga                                                   20


<210> 29783
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29783
agtactggca aaaggaacac                                                   20


<210> 29784
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29784
cagtactggc aaaaggaaca                                                   20


<210> 29785
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29785
tatctagcag tactggcaaa                                                   20


<210> 29786
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29786
ctatctagca gtactggcaa                                                   20


<210> 29787
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29787
tctaagctat ctagcagtac                                                   20


<210> 29788
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29788
cctggttcta agctatctag                                                   20


<210> 29789
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29789
catcctggtt ctaagctatc                                                   20


<210> 29790
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29790
tcataaatca tcctggttct                                                   20


<210> 29791
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29791
atgattttca taaatcatcc                                                   20


<210> 29792
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29792
agctgctaca gtgtgaattt                                                   20


<210> 29793
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29793
aagctgctac agtgtgaatt                                                   20


<210> 29794
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29794
aaatatatag aaagctgcta                                                   20


<210> 29795
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29795
aagctattca aatatataga                                                   20


<210> 29796
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29796
ttcaaagcta ttcaaatata                                                   20


<210> 29797
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29797
ctttcatttt aatcatttca                                                   20


<210> 29798
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29798
atgtccttgc atttgttatt                                                   20


<210> 29799
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29799
aatgtccttg catttgttat                                                   20


<210> 29800
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29800
gtgaagaaga ctttagaagt                                                   20


<210> 29801
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29801
gagagtgaag aagactttag                                                   20


<210> 29802
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29802
ctagagagtg aagaagactt                                                   20


<210> 29803
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29803
gaatacccta gagagtgaag                                                   20


<210> 29804
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29804
aatgaatacc ctagagagtg                                                   20


<210> 29805
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29805
agcataatga ataccctaga                                                   20


<210> 29806
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29806
aaagcataat gaatacccta                                                   20


<210> 29807
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29807
agaaagcata atgaataccc                                                   20


<210> 29808
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29808
gaaaataatg aaacattaga                                                   20


<210> 29809
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29809
acttgaaaat aatgaaacat                                                   20


<210> 29810
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29810
agctgttcat gggaaacctg                                                   20


<210> 29811
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29811
attggactac agctgttcat                                                   20


<210> 29812
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29812
aattggacta cagctgttca                                                   20


<210> 29813
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29813
tgtttgcact aattggacta                                                   20


<210> 29814
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29814
ctgagtgtgt ttgcactaat                                                   20


<210> 29815
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29815
atcctgactg tgttctgtct                                                   20


<210> 29816
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29816
ctttgatcca gtcagtgaag                                                   20


<210> 29817
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29817
gggctttgat ccagtcagtg                                                   20


<210> 29818
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29818
tgtaggggct ttgatccagt                                                   20


<210> 29819
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29819
caattgtagg ggctttgatc                                                   20


<210> 29820
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29820
aggcctgaag acaattgtag                                                   20


<210> 29821
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29821
caggcctgaa gacaattgta                                                   20


<210> 29822
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29822
tcaggcctga agacaattgt                                                   20


<210> 29823
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29823
ttcaggcctg aagacaattg                                                   20


<210> 29824
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29824
ttctcccatt ttcaggcctg                                                   20


<210> 29825
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29825
cacttttttc tcccattttc                                                   20


<210> 29826
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29826
acactttttt ctcccatttt                                                   20


<210> 29827
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29827
tgttttttgt ttcgattcag                                                   20


<210> 29828
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29828
gtgttttttg tttcgattca                                                   20


<210> 29829
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29829
ttgtgttttt tgtttcgatt                                                   20


<210> 29830
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29830
taatgcatga ctttctagga                                                   20


<210> 29831
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29831
gatataatgc atgactttct                                                   20


<210> 29832
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29832
tgatataatg catgactttc                                                   20


<210> 29833
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29833
tttttgaatt aggttactta                                                   20


<210> 29834
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29834
ttttttgaat taggttactt                                                   20


<210> 29835
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29835
cagaaggctt tttttgaatt                                                   20


<210> 29836
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29836
ccagaaggct ttttttgaat                                                   20


<210> 29837
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29837
tataaaatag caaacccaga                                                   20


<210> 29838
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29838
atataaaata gcaaacccag                                                   20


<210> 29839
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29839
tatatataaa atagcaaacc                                                   20


<210> 29840
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29840
aaaacaaagt atatataaaa                                                   20


<210> 29841
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29841
tgctgtaata tataaaaaca                                                   20


<210> 29842
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29842
tgacaaccta ggtattcttt                                                   20


<210> 29843
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29843
attgttcatt ttgacaacct                                                   20


<210> 29844
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29844
aattgttcat tttgacaacc                                                   20


<210> 29845
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29845
tatttttaaa gtggtttgaa                                                   20


<210> 29846
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29846
tacaaaaatt atttttaaag                                                   20


<210> 29847
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29847
acttacaaaa attattttta                                                   20


<210> 29848
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29848
gtggtttgtt tgacaaacat                                                   20


<210> 29849
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29849
tggtgccatt tatagagaag                                                   20


<210> 29850
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29850
ttttggtgcc atttatagag                                                   20


<210> 29851
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29851
ttgttttggt gccatttata                                                   20


<210> 29852
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29852
atttgttttg gtgccattta                                                   20


<210> 29853
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29853
ctatatgctg taatttgttt                                                   20


<210> 29854
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29854
ctttattgaa aattattaca                                                   20


<210> 29855
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29855
tctttattga aaattattac                                                   20


<210> 29856
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29856
cattgttttt tattttttct                                                   20


<210> 29857
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29857
agatcataaa tatcagcatg                                                   20


<210> 29858
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29858
gagatcataa atatcagcat                                                   20


<210> 29859
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29859
agagatcata aatatcagca                                                   20


<210> 29860
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29860
aggaaagaga tcataaatat                                                   20


<210> 29861
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29861
attttaaaat acttaggaaa                                                   20


<210> 29862
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29862
tgattttaaa atacttagga                                                   20


<210> 29863
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29863
taattgattt taaaatactt                                                   20


<210> 29864
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29864
ttaattgatt ttaaaatact                                                   20


<210> 29865
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29865
ttccatttgc ttatacagga                                                   20


<210> 29866
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29866
tttccatttg cttatacagg                                                   20


<210> 29867
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29867
gtttttccat ttgcttatac                                                   20


<210> 29868
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29868
tgtttttcca tttgcttata                                                   20


<210> 29869
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29869
aaatcttccc tcctgtctga                                                   20


<210> 29870
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29870
gaaatcttcc ctcctgtctg                                                   20


<210> 29871
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29871
tgaaatcttc cctcctgtct                                                   20


<210> 29872
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29872
ttaggatgag gatgactact                                                   20


<210> 29873
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29873
ttgcatgggt ctttaggatg                                                   20


<210> 29874
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29874
attgcatggg tctttaggat                                                   20


<210> 29875
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29875
aatcaattgc atgggtcttt                                                   20


<210> 29876
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29876
taatcaattg catgggtctt                                                   20


<210> 29877
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29877
ttgagtttaa tcaattgcat                                                   20


<210> 29878
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29878
tttgagttta atcaattgca                                                   20


<210> 29879
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29879
attatcaaaa gtcaaccttt                                                   20


<210> 29880
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29880
ttttccacaa tcattatcaa                                                   20


<210> 29881
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29881
gactttgatc ttttgaaaga                                                   20


<210> 29882
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29882
ggctgacttt gatcttttga                                                   20


<210> 29883
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29883
gagagtgggg ttaaacacca                                                   20


<210> 29884
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29884
tgagagtggg gttaaacacc                                                   20


<210> 29885
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29885
gtgagagtgg ggttaaacac                                                   20


<210> 29886
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29886
agtcattcca ggtgagagtg                                                   20


<210> 29887
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29887
cagtcattcc aggtgagagt                                                   20


<210> 29888
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29888
tcagtcattc caggtgagag                                                   20


<210> 29889
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29889
atttcagtca ttccaggtga                                                   20


<210> 29890
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29890
caatttcagt cattccaggt                                                   20


<210> 29891
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29891
aaaacaattt cagtcattcc                                                   20


<210> 29892
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29892
gaaaacaatt tcagtcattc                                                   20


<210> 29893
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29893
ccgagcattg aaaacaattt                                                   20


<210> 29894
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29894
gagaacattc agagttctcc                                                   20


<210> 29895
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29895
ctcagcattg agaacattca                                                   20


<210> 29896
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29896
gtctcagcat tgagaacatt                                                   20


<210> 29897
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29897
ctgggcaatg tctcagcatt                                                   20


<210> 29898
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29898
tgtggacctg ggcaatgtct                                                   20


<210> 29899
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29899
gtgacagagt ttgtggacct                                                   20


<210> 29900
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29900
tgtgacagag tttgtggacc                                                   20


<210> 29901
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29901
cagatatgtg acagagtttg                                                   20


<210> 29902
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29902
cctattacag atatgtgaca                                                   20


<210> 29903
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29903
cccctattac agatatgtga                                                   20


<210> 29904
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29904
gtgtataaac tcccctatta                                                   20


<210> 29905
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29905
tcataactcc aactatttgg                                                   20


<210> 29906
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29906
actcataact ccaactattt                                                   20


<210> 29907
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29907
cactcataac tccaactatt                                                   20


<210> 29908
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29908
agtaattggt gtgaagcatt                                                   20


<210> 29909
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29909
aagtaattgg tgtgaagcat                                                   20


<210> 29910
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29910
ggtaagaagt aattggtgtg                                                   20


<210> 29911
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29911
aatcccaggt aagaagtaat                                                   20


<210> 29912
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29912
tttctgtaat cccaggtaag                                                   20


<210> 29913
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29913
ctatttctgt aatcccaggt                                                   20


<210> 29914
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29914
aaaactattt ctgtaatccc                                                   20


<210> 29915
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29915
gaaaactatt tctgtaatcc                                                   20


<210> 29916
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29916
tcgaactttc agagtattga                                                   20


<210> 29917
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29917
cttcgaactt tcagagtatt                                                   20


<210> 29918
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29918
ttcagctctt cgaactttca                                                   20


<210> 29919
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29919
gtttcagctc ttcgaacttt                                                   20


<210> 29920
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29920
tgtaaaccta ggcaatgttt                                                   20


<210> 29921
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29921
ttaacagaat ttgtaaacct                                                   20


<210> 29922
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29922
tttaacagaa tttgtaaacc                                                   20


<210> 29923
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29923
ttaattctac aggtatttaa                                                   20


<210> 29924
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29924
taattctgat ttaattctac                                                   20


<210> 29925
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29925
ataattctga tttaattcta                                                   20


<210> 29926
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29926
aaaggctcag gtaagtatca                                                   20


<210> 29927
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29927
ccttgactaa aggctcaggt                                                   20


<210> 29928
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29928
aataccttga ctaaaggctc                                                   20


<210> 29929
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29929
aaataccttg actaaaggct                                                   20


<210> 29930
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29930
gtagaaaata ccttgactaa                                                   20


<210> 29931
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29931
cgtagaaaat accttgacta                                                   20


<210> 29932
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29932
taaaatagaa gccccaaacg                                                   20


<210> 29933
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29933
gaactataca tttaaaatag                                                   20


<210> 29934
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29934
gcagaactat acatttaaaa                                                   20


<210> 29935
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29935
atgatagcaa aaaagacttg                                                   20


<210> 29936
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29936
agttagttat gatagcaaaa                                                   20


<210> 29937
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29937
ttaaattaag ttagttatga                                                   20


<210> 29938
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29938
caatgctaat taaattaagt                                                   20


<210> 29939
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29939
aaatcaatgc taattaaatt                                                   20


<210> 29940
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29940
gtattttgtt tgcatcaaat                                                   20


<210> 29941
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29941
atttagttgt ttacgcattt                                                   20


<210> 29942
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29942
ggtccaacaa ttgaaacatt                                                   20


<210> 29943
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29943
ctaaattacc ataatgttaa                                                   20


<210> 29944
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29944
tctaaattac cataatgtta                                                   20


<210> 29945
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29945
gtctaaatta ccataatgtt                                                   20


<210> 29946
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29946
aatgttttat aaaaaattaa                                                   20


<210> 29947
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29947
agccttttgt gtctgacact                                                   20


<210> 29948
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29948
tggaaatatc aaacagtatg                                                   20


<210> 29949
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29949
ttatgaatgg aaatatcaaa                                                   20


<210> 29950
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29950
tatttggatt tttttatgaa                                                   20


<210> 29951
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29951
tctctatgga tttgtctatt                                                   20


<210> 29952
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29952
tcatctatgt tttatctcta                                                   20


<210> 29953
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29953
tccttctctc cctggcccct                                                   20


<210> 29954
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29954
cttcaatttc cttctctccc                                                   20


<210> 29955
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29955
agaaactctg tactcattag                                                   20


<210> 29956
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29956
aatagaaact ctgtactcat                                                   20


<210> 29957
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29957
agaagtttaa caaccccaaa                                                   20


<210> 29958
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29958
tcaccactac ctaattagag                                                   20


<210> 29959
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29959
acatcaccac tacctaatta                                                   20


<210> 29960
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29960
caacatcacc actacctaat                                                   20


<210> 29961
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29961
gtatacaatt cagtgttttt                                                   20


<210> 29962
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29962
caattttaaa gtatacaatt                                                   20


<210> 29963
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29963
ctacaaaatt cacaatttta                                                   20


<210> 29964
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29964
aggtctcctt tttttcctat                                                   20


<210> 29965
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29965
agaagactgc ctcttctcat                                                   20


<210> 29966
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29966
aagaagactg cctcttctca                                                   20


<210> 29967
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29967
taagaaaaca ttgtgcaaag                                                   20


<210> 29968
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29968
tgctaagaaa acattgtgca                                                   20


<210> 29969
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29969
tccatctgct acctgctgct                                                   20


<210> 29970
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29970
tgaggtcaca tatgatgggg                                                   20


<210> 29971
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29971
ttttgaggtc acatatgatg                                                   20


<210> 29972
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29972
cttttgaggt cacatatgat                                                   20


<210> 29973
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29973
ccttttgagg tcacatatga                                                   20


<210> 29974
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29974
catcaggctc cctccttttg                                                   20


<210> 29975
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29975
ccatcaggct ccctcctttt                                                   20


<210> 29976
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29976
tgcctaacct cttttccatc                                                   20


<210> 29977
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29977
ctgcctaacc tcttttccat                                                   20


<210> 29978
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29978
agacaataca gaagggtctt                                                   20


<210> 29979
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GGG

<400> 29979
gccacctaga caatacagaa                                                   20


<210> 29980
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29980
agccacctag acaatacaga                                                   20


<210> 29981
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29981
gagccaccta gacaatacag                                                   20


<210> 29982
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29982
ctggagccac ctagacaata                                                   20


<210> 29983
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29983
ccaggttcac tggagccacc                                                   20


<210> 29984
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29984
aaagtaatcc aggttcactg                                                   20


<210> 29985
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29985
tcaaagtaat ccaggttcac                                                   20


<210> 29986
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29986
ttgaattatc aaagtaatcc                                                   20


<210> 29987
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29987
tttgaattat caaagtaatc                                                   20


<210> 29988
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29988
ttaatgactt tgaattatca                                                   20


<210> 29989
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TAG

<400> 29989
gatttttaca atctcatatc                                                   20


<210> 29990
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: TGG

<400> 29990
aaatgtattt atcagaaaaa                                                   20


<210> 29991
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29991
cttttcccaa atgtatttat                                                   20


<210> 29992
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29992
tcaaggaaaa tattacatta                                                   20


<210> 29993
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AGG

<400> 29993
atacactcag tttattttca                                                   20


<210> 29994
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29994
tatacactca gtttattttc                                                   20


<210> 29995
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: CAG

<400> 29995
atacacatta tatatacact                                                   20


<210> 29996
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29996
tgtcactgct tactaagcct                                                   20


<210> 29997
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29997
aagagctgtc actgcttact                                                   20


<210> 29998
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: GAG

<400> 29998
aaaagtatat atttgtaaaa                                                   20


<210> 29999
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 29999
ataaaagtat atatttgtaa                                                   20


<210> 30000
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<223> Target: SCN9A; (-) strand; PAM type: NRG; 
      PAM sequence: AAG

<400> 30000
atttttgtat taaaatataa                                                   20
